# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- PH PF00169.29 CDW51741.1 - 2e-06 28.2 0.4 4.4e-06 27.2 0.4 1.6 1 0 0 1 1 1 1 PH domain Adaptin_N PF01602.20 CDW51741.1 - 0.17 10.4 2.6 1.1 7.7 0.8 2.2 1 1 1 2 2 2 0 Adaptin N terminal region FA_hydroxylase PF04116.13 CDW51742.1 - 1.1e-14 54.9 18.2 2.2e-14 54.0 18.2 1.5 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily Cyt-b5 PF00173.28 CDW51742.1 - 1.3e-06 28.4 0.1 5.5e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Ldl_recept_a PF00057.18 CDW51744.1 - 8.9e-05 22.6 3.3 0.00015 21.9 3.3 1.3 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A SUIM_assoc PF16619.5 CDW51744.1 - 0.028 14.5 3.9 0.056 13.5 3.9 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 WD40 PF00400.32 CDW51745.1 - 0.022 15.6 0.0 0.82 10.6 0.0 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat HLH PF00010.26 CDW51746.1 - 3.6e-17 62.1 1.3 8.3e-17 60.9 1.3 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Kunitz_BPTI PF00014.23 CDW51747.1 - 5.5e-57 189.8 32.3 2.6e-21 75.6 5.5 3.1 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain Kelch_3 PF13415.6 CDW51747.1 - 0.0002 21.6 3.0 1.4 9.3 0.1 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Methyltransf_15 PF09445.10 CDW51747.1 - 1.7 8.2 5.3 6.9 6.2 0.2 2.6 3 0 0 3 3 3 0 RNA cap guanine-N2 methyltransferase Pkinase PF00069.25 CDW51748.1 - 4.7e-78 262.2 0.0 6.1e-78 261.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW51748.1 - 9e-50 169.4 0.0 1.2e-49 169.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW51748.1 - 4.7e-11 42.5 0.0 1.6e-10 40.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDW51748.1 - 8e-06 24.9 0.1 1.1e-05 24.4 0.1 1.3 1 1 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CDW51748.1 - 0.00061 19.4 0.3 0.0014 18.3 0.1 1.6 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.14 CDW51748.1 - 0.0016 17.8 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDW51748.1 - 0.014 14.4 0.1 0.022 13.7 0.1 1.3 1 1 0 1 1 1 0 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 CDW51748.1 - 0.042 13.4 0.2 0.066 12.7 0.2 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 CDW51748.1 - 0.068 13.1 0.1 0.27 11.1 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 CDW51748.1 - 0.071 12.7 0.8 4.4 6.9 0.1 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 FAD_binding_2 PF00890.24 CDW51749.1 - 1e-82 278.5 1.7 1.2e-82 278.2 1.7 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CDW51749.1 - 4.1e-11 43.1 2.7 2.4e-10 40.5 2.7 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CDW51749.1 - 6.4e-08 32.1 9.7 0.0027 16.8 1.2 3.2 3 0 0 3 3 3 3 Glucose inhibited division protein A FAD_oxidored PF12831.7 CDW51749.1 - 1.1e-07 31.5 6.4 4.8e-07 29.5 6.4 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDW51749.1 - 2e-07 30.5 5.2 2.2e-05 23.8 2.3 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW51749.1 - 1.2e-05 25.4 0.2 3.5e-05 24.0 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CDW51749.1 - 0.00026 19.8 9.7 0.0046 15.7 1.0 3.3 3 0 0 3 3 3 2 HI0933-like protein Thi4 PF01946.17 CDW51749.1 - 0.0041 16.4 5.2 0.017 14.4 0.2 3.0 3 0 0 3 3 3 1 Thi4 family Pyr_redox PF00070.27 CDW51749.1 - 0.012 16.2 2.5 0.68 10.5 0.6 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDW51749.1 - 0.025 13.9 0.2 0.054 12.8 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mqo PF06039.15 CDW51749.1 - 0.029 12.9 0.1 1.7 7.1 0.1 2.1 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Glyco_transf_7N PF13733.6 CDW51750.1 - 1.7e-46 157.2 0.0 2.7e-46 156.5 0.0 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 CDW51750.1 - 2.2e-30 104.1 2.5 1.1e-28 98.7 0.9 2.4 2 0 0 2 2 2 2 N-terminal domain of galactosyltransferase DUF1296 PF06972.11 CDW51751.1 - 0.031 14.4 0.1 0.065 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) F-box-like PF12937.7 CDW51753.1 - 0.00011 22.0 1.1 0.00024 20.9 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CDW51753.1 - 0.00015 21.5 0.0 0.00045 20.0 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CDW51753.1 - 0.0026 17.6 0.1 0.0048 16.8 0.1 1.4 1 0 0 1 1 1 1 F-box LRR_4 PF12799.7 CDW51753.1 - 0.012 16.0 0.1 0.039 14.4 0.1 1.9 1 1 0 1 1 1 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDW51753.1 - 0.025 14.3 0.2 0.22 11.3 0.2 2.4 1 1 1 2 2 2 0 Leucine rich repeat LRR_2 PF07723.13 CDW51753.1 - 0.073 13.8 1.7 0.58 10.9 1.0 2.5 2 0 0 2 2 2 0 Leucine Rich Repeat Orai-1 PF07856.12 CDW51754.1 - 0.061 13.0 0.2 0.061 13.0 0.2 3.1 3 1 1 4 4 4 0 Mediator of CRAC channel activity PDZ PF00595.24 CDW51755.1 - 1.4e-22 79.8 2.1 8.2e-13 48.5 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 CDW51755.1 - 7.5e-15 54.5 0.0 3.6e-06 26.7 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 CDW51755.1 - 1.8e-07 31.4 0.4 0.056 13.8 0.0 3.3 3 0 0 3 3 3 2 PDZ domain Tricorn_PDZ PF14685.6 CDW51755.1 - 0.14 12.2 0.0 5.2 7.1 0.0 2.5 2 0 0 2 2 2 0 Tricorn protease PDZ domain LRR_8 PF13855.6 CDW51756.1 - 2.3e-17 62.5 7.3 1.1e-13 50.8 0.1 2.4 1 1 1 2 2 2 2 Leucine rich repeat I-set PF07679.16 CDW51756.1 - 2.2e-10 40.5 0.0 4.7e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW51756.1 - 6e-10 39.6 0.0 1.7e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 CDW51756.1 - 4.5e-09 36.0 0.2 7.6e-09 35.3 0.2 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 CDW51756.1 - 2.2e-08 34.2 4.0 0.00048 20.5 0.0 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW51756.1 - 2.3e-07 30.8 0.1 3.5e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Ig_2 PF13895.6 CDW51756.1 - 0.00029 21.1 0.0 0.0014 18.9 0.0 2.1 1 1 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 CDW51756.1 - 0.00031 20.8 0.0 0.00085 19.5 0.0 1.7 1 1 0 1 1 1 1 Immunoglobulin domain DAG1 PF05454.11 CDW51756.1 - 0.0073 15.7 0.5 0.012 15.1 0.5 1.3 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) LRR_1 PF00560.33 CDW51756.1 - 0.009 16.4 3.0 17 6.5 0.2 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat V-set PF07686.17 CDW51756.1 - 0.02 15.1 0.0 0.049 13.8 0.0 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain LRR_6 PF13516.6 CDW51756.1 - 0.027 14.5 2.2 0.29 11.3 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich repeat Shisa PF13908.6 CDW51756.1 - 0.035 14.4 0.2 0.052 13.8 0.2 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ODV-E18 PF10717.9 CDW51756.1 - 0.065 13.1 0.5 0.13 12.1 0.5 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Ig_6 PF18452.1 CDW51756.1 - 0.088 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain ECSCR PF15820.5 CDW51756.1 - 0.13 12.1 1.6 0.25 11.2 1.6 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator EphA2_TM PF14575.6 CDW51756.1 - 0.14 13.1 0.1 0.27 12.1 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM154 PF15102.6 CDW51756.1 - 3.9 7.4 5.6 7.5 6.4 5.6 1.4 1 1 0 1 1 1 0 TMEM154 protein family Rad17 PF03215.15 CDW51757.1 - 3.9e-22 79.1 0.0 9.9e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 CDW51757.1 - 0.00032 21.0 0.0 0.00085 19.6 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain AAA_16 PF13191.6 CDW51757.1 - 0.022 15.2 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 CDW51757.1 - 0.024 15.1 0.0 0.049 14.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 CDW51757.1 - 0.055 12.5 0.0 0.09 11.8 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein HECT PF00632.25 CDW51759.1 - 1.7e-58 198.5 0.8 2.5e-58 198.0 0.8 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) HCO3_cotransp PF00955.21 CDW51760.1 - 1.4e-165 552.0 16.9 1.8e-165 551.6 16.9 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 CDW51760.1 - 1.1e-27 97.5 0.2 1.1e-26 94.3 0.2 2.1 1 1 0 1 1 1 1 Band 3 cytoplasmic domain DUF3921 PF13060.6 CDW51760.1 - 0.16 12.0 0.0 0.4 10.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3921) DUF3693 PF12472.8 CDW51760.1 - 0.52 10.0 1.9 1.7 8.4 0.7 2.2 2 0 0 2 2 2 0 Phage related protein Collagen PF01391.18 CDW51761.1 - 1.2e-27 95.4 88.1 1.1e-09 37.9 28.2 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW51761.1 - 2.8e-10 40.1 0.0 3.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Forkhead PF00250.18 CDW51763.1 - 3.4e-33 113.8 0.0 1e-32 112.2 0.0 1.9 1 0 0 1 1 1 1 Forkhead domain NAD_synthase PF02540.17 CDW51764.1 - 1.8e-30 105.8 0.0 3e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.22 CDW51764.1 - 8.6e-15 54.8 0.0 4e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase Asn_synthase PF00733.21 CDW51764.1 - 0.033 13.8 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase EF-hand_2 PF09068.11 CDW51765.1 - 1.1e-32 112.8 1.2 1.1e-32 112.8 1.2 1.9 3 0 0 3 3 2 1 EF hand EF-hand_3 PF09069.11 CDW51765.1 - 1e-21 77.1 0.0 2.8e-21 75.7 0.0 1.8 1 0 0 1 1 1 1 EF-hand ZZ PF00569.17 CDW51765.1 - 1.1e-12 47.5 7.6 2.4e-12 46.4 7.6 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 CDW51765.1 - 9.6e-05 22.6 7.7 0.00026 21.3 7.7 1.7 1 0 0 1 1 1 1 C1 domain AAA_32 PF13654.6 CDW51765.1 - 0.023 13.5 0.5 0.039 12.8 0.5 1.3 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 CDW51765.1 - 0.098 11.3 0.4 0.15 10.6 0.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A STAT_alpha PF01017.20 CDW51765.1 - 0.17 11.8 3.3 0.45 10.4 3.3 1.7 1 0 0 1 1 1 0 STAT protein, all-alpha domain GIT_CC PF16559.5 CDW51765.1 - 1.6 8.7 12.2 0.26 11.2 0.4 3.0 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 CDW51765.1 - 3.7 7.9 6.5 21 5.5 0.4 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family Seryl_tRNA_N PF02403.22 CDW51765.1 - 5.5 7.3 9.7 0.73 10.1 5.1 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DivIC PF04977.15 CDW51765.1 - 6 6.7 8.3 18 5.2 0.6 2.6 2 0 0 2 2 2 0 Septum formation initiator DMPK_coil PF08826.10 CDW51765.1 - 6.4 7.0 9.0 16 5.7 0.7 2.7 2 0 0 2 2 2 0 DMPK coiled coil domain like Chromosome_seg PF13889.6 CDW51766.1 - 2.2e-18 66.1 0.1 4.7e-18 65.1 0.1 1.6 1 1 0 1 1 1 1 Chromosome segregation during meiosis DUF4210 PF13915.6 CDW51766.1 - 1.7e-06 28.5 0.1 3e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) RhoGEF PF00621.20 CDW51767.1 - 1.4e-28 100.4 0.0 2.5e-28 99.6 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain RBD PF02196.15 CDW51767.1 - 9.2e-08 32.1 0.0 9e-07 28.9 0.0 2.6 2 0 0 2 2 2 1 Raf-like Ras-binding domain HLH PF00010.26 CDW51768.1 - 1.9e-12 46.9 5.2 4.3e-12 45.8 5.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Basic PF01586.16 CDW51768.1 - 6.3e-11 43.3 1.9 6.3e-11 43.3 1.9 2.8 2 2 0 2 2 2 1 Myogenic Basic domain Myf5 PF12232.8 CDW51768.1 - 0.00015 22.4 0.0 0.00015 22.4 0.0 3.3 3 1 1 4 4 4 1 Myogenic determination factor 5 C2 PF00168.30 CDW51769.1 - 1.1e-44 150.9 0.1 1.7e-21 76.4 0.0 3.4 2 1 1 3 3 3 3 C2 domain DUF639 PF04842.12 CDW51769.1 - 1.4e-08 34.5 1.9 2.3e-08 33.8 1.9 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) PRT_C PF08372.10 CDW51769.1 - 1.3e-05 25.0 3.2 3.7e-05 23.5 0.1 2.2 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal CEP76-C2 PF15627.6 CDW51769.1 - 0.00012 21.7 0.1 0.00039 20.0 0.0 1.9 2 0 0 2 2 2 1 CEP76 C2 domain Reticulon PF02453.17 CDW51769.1 - 0.008 16.1 4.7 0.013 15.5 3.8 1.8 2 1 0 2 2 2 1 Reticulon Pex24p PF06398.11 CDW51769.1 - 0.05 12.6 3.6 0.078 11.9 3.6 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Frataxin_Cyay PF01491.16 CDW51770.1 - 2.3e-38 130.6 0.0 2.9e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain HIT PF01230.23 CDW51771.1 - 5.9e-31 107.1 0.0 6.9e-31 106.9 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CDW51771.1 - 5.5e-21 75.2 0.0 6.4e-21 75.0 0.0 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding L51_S25_CI-B8 PF05047.16 CDW51772.1 - 2.2e-06 27.5 0.0 8.5e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CRAL_TRIO PF00650.20 CDW51773.1 - 2.7e-30 105.2 0.0 3.5e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 CDW51773.1 - 2.2e-06 28.2 0.8 0.0059 17.1 0.2 2.4 1 1 1 2 2 2 2 Golgi-dynamics membrane-trafficking CRAL_TRIO_2 PF13716.6 CDW51773.1 - 0.0061 16.7 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Hint PF01079.20 CDW51774.1 - 1.3e-30 106.5 0.1 1.6e-30 106.3 0.1 1.1 1 0 0 1 1 1 1 Hint module Abhydrolase_2 PF02230.16 CDW51775.1 - 8.8e-67 225.1 0.2 9.7e-67 224.9 0.2 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 CDW51775.1 - 5.1e-05 24.0 0.1 5.8e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CDW51775.1 - 0.00018 21.2 0.0 0.00023 20.8 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 CDW51775.1 - 0.00021 21.0 0.0 0.0003 20.5 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 CDW51775.1 - 0.00047 20.1 0.0 0.00061 19.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDW51775.1 - 0.00061 19.1 0.1 0.43 9.8 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CDW51775.1 - 0.00069 19.1 0.1 0.12 11.8 0.0 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase family DUF2974 PF11187.8 CDW51775.1 - 0.0015 18.2 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 CDW51775.1 - 0.017 14.8 0.3 0.051 13.2 0.3 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 CDW51775.1 - 0.054 13.4 0.0 0.082 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 CDW51775.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Picorna_P3A PF06363.11 CDW51775.1 - 0.17 11.8 0.0 7.8 6.4 0.0 2.2 2 0 0 2 2 2 0 Picornaviridae P3A protein BAAT_C PF08840.11 CDW51775.1 - 0.17 11.8 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal HS1_rep PF02218.15 CDW51776.1 - 2.2e-37 127.1 11.1 8.4e-19 67.6 0.8 2.9 3 0 0 3 3 3 2 Repeat in HS1/Cortactin SH3_1 PF00018.28 CDW51776.1 - 2.6e-15 55.7 1.2 1.5e-14 53.3 0.1 2.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CDW51776.1 - 3.1e-13 49.4 0.1 6.6e-13 48.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CDW51776.1 - 9.3e-08 31.6 0.0 2.5e-07 30.3 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Ribosomal_S18 PF01084.20 CDW51777.1 - 3.8e-18 65.4 0.1 7.5e-18 64.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 MutS_V PF00488.21 CDW51778.1 - 6.4e-41 140.4 0.1 1.6e-40 139.2 0.1 1.6 1 1 0 1 1 1 1 MutS domain V MutS_IV PF05190.18 CDW51778.1 - 0.0023 18.2 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 MutS family domain IV Molybdopterin PF00384.22 CDW51779.1 - 5.6e-65 220.0 0.0 1e-63 215.8 0.0 2.1 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 CDW51779.1 - 2.2e-16 59.7 0.2 6.4e-16 58.2 0.2 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 CDW51779.1 - 1.4e-15 56.5 0.1 1.4e-15 56.5 0.1 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 CDW51779.1 - 2.1e-06 28.3 0.1 4.8e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 CDW51779.1 - 7.9e-06 25.7 0.4 7.9e-06 25.7 0.4 2.3 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.27 CDW51779.1 - 0.13 12.1 1.3 4.4 7.3 0.4 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Na_H_Exchanger PF00999.21 CDW51780.1 - 8.3e-80 268.4 46.3 1.1e-79 268.1 46.3 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family zf-C2H2 PF00096.26 CDW51781.1 - 6.6e-22 76.7 76.9 3.1e-05 24.2 0.5 9.7 10 0 0 10 10 10 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW51781.1 - 4.2e-19 67.6 82.8 0.00071 20.2 2.4 10.7 9 1 1 10 10 10 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW51781.1 - 4.5e-16 58.5 67.0 1.8e-07 31.3 0.3 8.4 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW51781.1 - 2.8e-09 37.0 58.3 0.0072 16.6 0.9 8.5 9 1 0 9 9 9 6 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW51781.1 - 3.9e-08 33.4 80.7 0.0041 17.5 1.5 9.7 11 1 1 12 12 12 7 Zinc-finger of C2H2 type BolA PF01722.18 CDW51781.1 - 0.002 18.4 5.4 2.7 8.3 0.1 3.6 3 0 0 3 3 3 2 BolA-like protein zf-C2H2_11 PF16622.5 CDW51781.1 - 2.3 8.1 48.6 0.45 10.3 0.7 7.5 7 0 0 7 7 7 0 zinc-finger C2H2-type DUF1459 PF07312.11 CDW51781.1 - 3.3 8.0 6.6 0.73 10.1 2.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1459) zf-C2H2_6 PF13912.6 CDW51781.1 - 6.1 7.0 72.1 0.13 12.2 1.6 8.8 8 0 0 8 8 8 0 C2H2-type zinc finger Tub PF01167.18 CDW51782.1 - 2.4e-85 286.1 0.2 4.5e-85 285.2 0.0 1.5 2 0 0 2 2 2 1 Tub family Macoilin PF09726.9 CDW51782.1 - 0.32 9.5 5.1 0.37 9.3 5.1 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 CDW51782.1 - 1.7 7.4 10.5 2.4 6.9 10.5 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain ATG16 PF08614.11 CDW51782.1 - 1.8 8.7 8.1 2.6 8.2 8.1 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Zona_pellucida PF00100.23 CDW51784.1 - 2.7e-10 40.5 7.7 4.5e-10 39.8 7.7 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Hist_deacetyl PF00850.19 CDW51786.1 - 3.5e-77 259.9 0.1 4.6e-77 259.5 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain NIL PF09383.10 CDW51786.1 - 0.00033 20.5 0.0 0.00061 19.6 0.0 1.4 1 0 0 1 1 1 1 NIL domain SUA5 PF03481.13 CDW51786.1 - 0.17 12.4 0.0 0.36 11.4 0.0 1.6 1 0 0 1 1 1 0 Putative GTP-binding controlling metal-binding UPF0183 PF03676.14 CDW51787.1 - 2.2e-85 287.3 0.0 2.6e-85 287.1 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) LRR_8 PF13855.6 CDW51788.1 - 1.4e-41 140.1 42.4 5.7e-09 35.6 2.3 7.7 6 2 2 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 CDW51788.1 - 4.8e-16 58.6 43.2 0.00042 20.6 0.9 9.1 4 3 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDW51788.1 - 5.9e-10 38.3 39.2 0.95 10.3 0.1 11.8 13 0 0 13 13 13 5 Leucine Rich Repeat LRR_5 PF13306.6 CDW51788.1 - 6.4e-10 39.1 0.0 2.3e-05 24.4 0.0 3.4 3 1 1 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 CDW51788.1 - 9.4e-08 31.8 12.5 0.0049 16.4 0.7 4.8 1 1 4 5 5 5 4 Leucine-rich repeat Syndecan PF01034.20 CDW51788.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain LRR_6 PF13516.6 CDW51788.1 - 8.3 6.8 46.6 0.21 11.7 0.5 9.8 12 0 0 12 12 12 0 Leucine Rich repeat UPF0183 PF03676.14 CDW51790.1 - 2.9e-39 135.5 0.1 3.3e-39 135.3 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) TEBP_beta PF07404.11 CDW51795.1 - 3.4 6.9 11.1 4 6.7 11.1 1.0 1 0 0 1 1 1 0 Telomere-binding protein beta subunit (TEBP beta) Bromodomain PF00439.25 CDW51796.1 - 2.5e-21 75.5 0.1 1e-19 70.4 0.0 2.4 2 0 0 2 2 2 1 Bromodomain WD40 PF00400.32 CDW51796.1 - 4.4e-06 27.3 15.2 5.9e-05 23.7 0.1 6.9 8 0 0 8 8 8 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW51796.1 - 5.2e-06 26.7 0.0 0.56 10.5 0.0 4.5 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Spem1 PF15670.5 CDW51796.1 - 2.7 7.5 12.2 0.27 10.8 1.7 2.4 2 0 0 2 2 2 0 Spermatid maturation protein 1 Acyltransferase PF01553.21 CDW51797.1 - 2.3e-19 69.4 0.0 3.5e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CDW51797.1 - 2.4e-08 34.0 0.1 4.3e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus DUF5381 PF17353.2 CDW51797.1 - 4.6 7.0 6.0 3 7.6 4.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5381) 7tm_1 PF00001.21 CDW51798.1 - 0.018 14.3 21.9 0.15 11.4 21.4 2.2 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) SDA1 PF05285.12 CDW51799.1 - 3e-58 197.9 37.9 5.3e-56 190.5 23.1 3.3 2 1 0 2 2 2 2 SDA1 PDZ PF00595.24 CDW51799.1 - 3.8e-12 46.4 0.6 3.4e-07 30.5 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 CDW51799.1 - 6.4e-12 45.1 0.3 7.6e-06 25.7 0.1 2.4 2 0 0 2 2 2 2 PDZ domain NUC130_3NT PF08158.12 CDW51799.1 - 2.3e-09 37.4 2.7 3.3e-09 36.9 0.4 2.7 3 0 0 3 3 3 1 NUC130/3NT domain CLPTM1 PF05602.12 CDW51799.1 - 0.18 10.8 0.9 0.84 8.6 1.7 1.6 2 0 0 2 2 2 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Peptidase_C1 PF00112.23 CDW51800.1 - 4.9e-50 170.6 1.0 4.9e-50 170.6 1.0 1.7 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 CDW51800.1 - 1.7e-11 44.4 3.6 4.8e-11 42.9 3.6 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 CDW51800.1 - 0.0026 16.6 0.1 0.011 14.5 0.0 1.9 2 0 0 2 2 2 1 Peptidase C1-like family Peptidase_S9 PF00326.21 CDW51801.1 - 7.3e-45 153.0 0.1 1.5e-44 152.0 0.1 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDW51801.1 - 3.3e-11 43.3 0.1 2.3e-08 34.0 0.1 2.4 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 CDW51801.1 - 3.3e-07 30.2 0.2 0.00038 20.2 0.3 2.7 2 1 1 3 3 3 2 alpha/beta hydrolase fold DLH PF01738.18 CDW51801.1 - 1e-06 28.4 0.0 0.00059 19.5 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CDW51801.1 - 5.5e-06 25.8 0.0 0.012 14.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Esterase PF00756.20 CDW51801.1 - 0.00085 19.0 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 CDW51801.1 - 0.0015 18.4 0.0 1.3 8.8 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CDW51801.1 - 0.0016 18.3 0.1 0.005 16.7 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 CDW51801.1 - 0.0029 17.6 0.0 0.035 14.0 0.0 2.5 2 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal PAF-AH_p_II PF03403.13 CDW51801.1 - 0.011 14.3 0.0 0.032 12.8 0.0 1.7 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II LIP PF03583.14 CDW51801.1 - 0.012 14.9 0.0 4.6 6.5 0.0 2.2 2 0 0 2 2 2 0 Secretory lipase Globin PF00042.22 CDW51802.1 - 6.8e-06 26.6 0.0 1.3e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Globin Protoglobin PF11563.8 CDW51802.1 - 0.0014 18.5 0.1 0.0026 17.7 0.1 1.3 1 0 0 1 1 1 1 Protoglobin DUF2949 PF11165.8 CDW51802.1 - 0.083 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2949) COesterase PF00135.28 CDW51803.1 - 6.5e-145 483.9 0.0 7.8e-145 483.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW51803.1 - 7.8e-06 25.9 0.2 2.6e-05 24.2 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDW51803.1 - 0.00082 18.9 0.4 0.0014 18.1 0.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 CDW51803.1 - 0.0077 15.2 0.2 0.013 14.4 0.2 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme PAF-AH_p_II PF03403.13 CDW51803.1 - 0.052 12.1 0.2 0.21 10.0 0.1 1.9 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Methyltransf_32 PF13679.6 CDW51804.1 - 3.7e-24 85.5 0.2 6.3e-24 84.7 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW51804.1 - 0.0038 17.0 0.0 0.0077 16.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW51804.1 - 0.018 15.8 0.0 0.055 14.2 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CDW51804.1 - 0.055 13.3 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Kelch_1 PF01344.25 CDW51805.1 - 5.6e-39 131.5 23.4 3.7e-12 45.6 0.8 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 CDW51805.1 - 8.4e-19 67.1 9.4 1.1e-07 31.9 0.0 5.6 2 2 3 5 5 5 4 Kelch motif BTB PF00651.31 CDW51805.1 - 4.5e-14 52.6 0.0 2.1e-13 50.5 0.0 2.0 1 1 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 CDW51805.1 - 5.2e-14 52.1 2.4 0.00038 20.7 0.0 4.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 CDW51805.1 - 3.9e-08 32.9 4.5 1.2 9.2 0.1 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_5 PF13854.6 CDW51805.1 - 9e-08 31.9 3.0 5.5e-05 23.1 0.1 4.5 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 CDW51805.1 - 1.7e-07 31.1 0.1 0.0053 16.8 0.0 4.2 4 0 0 4 4 4 2 Galactose oxidase, central domain BACK PF07707.15 CDW51805.1 - 0.00041 20.4 1.6 0.0016 18.5 0.2 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF5444 PF17519.2 CDW51805.1 - 0.094 12.7 1.0 2.6 8.1 0.0 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5444) C2 PF00168.30 CDW51807.1 - 2.3e-56 188.4 0.2 4.4e-30 104.0 0.0 2.1 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 CDW51807.1 - 2.5e-06 27.1 0.0 0.0012 18.4 0.0 2.2 2 0 0 2 2 2 2 CEP76 C2 domain PI3K_C2 PF00792.24 CDW51807.1 - 0.0094 15.9 0.0 0.36 10.8 0.0 2.3 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 PTEN_C2 PF10409.9 CDW51807.1 - 0.056 13.2 2.2 9.3 6.0 0.2 3.0 2 1 1 3 3 3 0 C2 domain of PTEN tumour-suppressor protein Tafi-CsgC PF10610.9 CDW51807.1 - 0.062 13.5 0.0 2.9 8.2 0.0 2.4 2 0 0 2 2 2 0 Thin aggregative fimbriae synthesis protein DOCK-C2 PF14429.6 CDW51807.1 - 0.079 12.8 0.0 1.1 9.1 0.0 2.0 2 0 0 2 2 2 0 C2 domain in Dock180 and Zizimin proteins BTB PF00651.31 CDW51808.1 - 8.9e-19 67.8 0.1 1.7e-18 66.9 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 CDW51808.1 - 2.6e-12 46.7 2.1 4.3e-10 39.6 1.8 2.6 1 1 1 2 2 2 2 BTB And C-terminal Kelch zf-MYND PF01753.18 CDW51809.1 - 3.3e-06 27.1 15.2 3.3e-06 27.1 15.2 3.6 2 1 0 2 2 2 1 MYND finger UvsY PF11056.8 CDW51809.1 - 0.12 12.8 0.7 0.24 11.8 0.7 1.4 1 0 0 1 1 1 0 Recombination, repair and ssDNA binding protein UvsY OrfB_Zn_ribbon PF07282.11 CDW51809.1 - 4.4 7.3 14.2 0.64 10.0 0.4 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Nuc_deoxyri_tr2 PF15891.5 CDW51810.1 - 7.4e-05 23.0 0.0 0.00012 22.4 0.0 1.3 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like Zona_pellucida PF00100.23 CDW51811.1 - 4.8e-15 56.1 0.1 7e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain DUF4094 PF13334.6 CDW51811.1 - 0.14 12.6 0.0 0.3 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) MutS_V PF00488.21 CDW51812.1 - 1.8e-59 201.0 0.0 3.2e-59 200.1 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 CDW51812.1 - 1e-35 122.4 0.1 2e-35 121.5 0.1 1.4 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 CDW51812.1 - 1e-23 84.6 0.1 2.6e-23 83.3 0.1 1.7 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CDW51812.1 - 1.6e-14 54.0 0.2 3.3e-14 53.0 0.2 1.6 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 CDW51812.1 - 0.062 13.6 0.0 0.57 10.5 0.0 2.4 1 1 0 1 1 1 0 MutS domain II AAA_14 PF13173.6 CDW51812.1 - 0.13 12.2 0.1 2.1 8.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain DTC PF18102.1 CDW51812.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Deltex C-terminal domain AAA_29 PF13555.6 CDW51812.1 - 0.17 11.7 0.1 0.39 10.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PseudoU_synth_1 PF01416.20 CDW51813.1 - 1.5e-16 60.8 0.0 3.6e-13 49.9 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase RabGAP-TBC PF00566.18 CDW51814.1 - 1.9e-51 174.8 4.6 3.3e-51 174.0 4.6 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rab5-bind PF09311.11 CDW51814.1 - 0.044 13.2 0.2 0.081 12.3 0.2 1.4 1 0 0 1 1 1 0 Rabaptin-like protein Ribonuc_2-5A PF06479.12 CDW51814.1 - 1.6 8.9 5.6 9.6 6.4 0.6 3.2 2 1 1 3 3 3 0 Ribonuclease 2-5A Ribosomal_S11 PF00411.19 CDW51815.1 - 1.7e-46 157.2 1.3 2.1e-46 156.9 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 CDW51815.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) SIR2 PF02146.17 CDW51816.1 - 1.9e-56 190.8 0.0 2.4e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Sir2 family HypA PF01155.19 CDW51816.1 - 0.11 12.6 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 CDW51816.1 - 0.14 12.1 1.6 0.79 9.7 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Zip PF02535.22 CDW51817.1 - 2.4e-61 207.8 28.5 4.1e-60 203.8 22.7 2.7 2 1 0 2 2 2 1 ZIP Zinc transporter Proteasome PF00227.26 CDW51818.1 - 4.1e-35 121.0 0.0 4.9e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit DUF4860 PF16152.5 CDW51819.1 - 0.054 13.4 0.0 0.34 10.8 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4860) Spectrin_like PF18373.1 CDW51819.1 - 0.094 12.8 0.1 0.26 11.4 0.0 1.8 2 0 0 2 2 2 0 Spectrin like domain Ribosomal_S5 PF00333.20 CDW51820.1 - 3.5e-30 103.8 0.9 7.9e-30 102.6 0.9 1.7 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CDW51820.1 - 1.8e-24 85.0 0.0 3e-24 84.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain ATP_synth_reg PF14960.6 CDW51820.1 - 0.0097 15.4 1.0 0.02 14.4 1.0 1.4 1 0 0 1 1 1 1 ATP synthase regulation Med22 PF06179.12 CDW51821.1 - 5.8e-24 84.3 5.8 1.2e-23 83.3 5.8 1.5 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Joubert PF15392.6 CDW51821.1 - 0.12 12.0 2.6 0.21 11.3 2.6 1.4 1 0 0 1 1 1 0 Joubert syndrome-associated WD40 PF00400.32 CDW51822.1 - 1.7e-45 152.1 16.4 1.7e-07 31.8 0.4 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat zf-NOSIP PF15906.5 CDW51822.1 - 3.6e-34 116.7 0.8 9.5e-34 115.4 0.8 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein ANAPC4_WD40 PF12894.7 CDW51822.1 - 2e-10 40.8 0.1 0.47 10.8 0.0 5.7 3 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Rtf2 PF04641.12 CDW51822.1 - 1.2e-08 34.7 8.0 0.00025 20.5 0.0 2.9 2 1 1 3 3 3 2 Rtf2 RING-finger U-box PF04564.15 CDW51822.1 - 3.7e-07 30.2 0.0 0.012 15.8 0.0 3.1 4 0 0 4 4 4 2 U-box domain Ge1_WD40 PF16529.5 CDW51822.1 - 3.7e-06 26.1 0.2 0.26 10.2 0.1 4.1 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CDW51822.1 - 4.9e-05 23.3 0.4 0.097 12.5 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 CDW51822.1 - 0.00057 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 CDW51822.1 - 0.0061 15.3 2.5 0.025 13.3 0.1 2.8 2 1 2 4 4 4 1 Nucleoporin Nup120/160 MBD_C PF14048.6 CDW51823.1 - 7.3e-27 93.9 0.0 1.4e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.5 CDW51823.1 - 3e-10 40.1 0.1 6.9e-10 39.0 0.1 1.6 1 0 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD Sulfate_transp PF00916.20 CDW51824.1 - 2.8e-142 474.0 47.6 1.4e-74 251.2 18.1 2.9 2 1 0 2 2 2 2 Sulfate permease family STAS PF01740.21 CDW51824.1 - 3.4e-22 78.3 0.0 2.2e-10 40.2 0.0 2.5 2 0 0 2 2 2 2 STAS domain MFS_MOT1 PF16983.5 CDW51824.1 - 0.00027 21.3 0.9 0.00027 21.3 0.9 4.5 5 1 0 5 5 5 1 Molybdate transporter of MFS superfamily FR47 PF08445.10 CDW51825.1 - 7.3e-05 22.7 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 CDW51825.1 - 0.00021 21.5 0.0 0.00032 20.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW51825.1 - 0.0016 18.4 0.0 0.0039 17.1 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDW51825.1 - 0.017 15.8 0.0 0.054 14.2 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW51825.1 - 0.048 14.1 0.0 0.086 13.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CDW51825.1 - 0.049 13.1 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase DUF4803 PF16061.5 CDW51825.1 - 0.051 13.0 0.0 0.079 12.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4803) RPW8 PF05659.11 CDW51825.1 - 0.089 12.5 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 S-methyl_trans PF02574.16 CDW51825.1 - 0.12 12.2 0.0 0.26 11.0 0.0 1.5 1 1 1 2 2 2 0 Homocysteine S-methyltransferase Cadherin PF00028.17 CDW51826.1 - 3.8e-131 427.9 10.5 6.2e-19 68.2 0.2 10.1 9 1 0 9 9 9 8 Cadherin domain EGF PF00008.27 CDW51826.1 - 1.5e-21 76.3 54.0 6.2e-07 29.6 5.9 6.2 6 0 0 6 6 6 4 EGF-like domain Laminin_G_2 PF02210.24 CDW51826.1 - 7.6e-21 75.0 0.1 4.7e-20 72.4 0.0 2.5 2 0 0 2 2 2 1 Laminin G domain Laminin_G_1 PF00054.23 CDW51826.1 - 1.1e-18 67.7 0.0 2.5e-18 66.5 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain Cadherin_2 PF08266.12 CDW51826.1 - 1.3e-12 47.4 0.1 0.54 10.1 0.0 8.4 8 0 0 8 8 8 3 Cadherin-like Cadherin_3 PF16184.5 CDW51826.1 - 9.8e-10 38.4 15.4 0.14 12.2 0.1 8.3 8 0 0 8 8 8 3 Cadherin-like hEGF PF12661.7 CDW51826.1 - 9.8e-10 38.7 46.0 0.00025 21.6 4.3 6.8 6 0 0 6 6 6 3 Human growth factor-like EGF Cadherin_4 PF17803.1 CDW51826.1 - 1.1e-06 29.2 25.6 0.014 16.0 0.3 7.6 8 0 0 8 8 8 3 Bacterial cadherin-like domain Laminin_EGF PF00053.24 CDW51826.1 - 2e-06 27.8 14.0 2e-06 27.8 14.0 7.6 7 2 1 8 8 7 3 Laminin EGF domain RET_CLD1 PF17756.1 CDW51826.1 - 5.4e-05 23.5 0.0 4 7.8 0.0 5.4 7 0 0 7 7 7 1 RET Cadherin like domain 1 Big_9 PF17963.1 CDW51826.1 - 0.00092 19.9 23.2 0.43 11.4 1.7 6.1 6 0 0 6 6 6 2 Bacterial Ig domain GBR2_CC PF18455.1 CDW51826.1 - 0.16 12.1 0.1 0.49 10.6 0.1 1.8 1 0 0 1 1 1 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain Ephrin PF00812.17 CDW51827.1 - 1.7e-18 67.0 0.0 2.4e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Ephrin Ephrin PF00812.17 CDW51828.1 - 5.4e-24 84.8 0.1 1.4e-23 83.4 0.1 1.7 1 1 0 1 1 1 1 Ephrin DUF866 PF05907.13 CDW51829.1 - 2.1e-43 147.9 3.0 2.4e-43 147.7 3.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Zn-ribbon_8 PF09723.10 CDW51829.1 - 0.054 13.6 2.2 1.1 9.4 2.3 2.5 1 1 1 2 2 2 0 Zinc ribbon domain Desulfoferrod_N PF06397.12 CDW51829.1 - 0.13 11.9 2.8 8.1 6.2 0.0 2.7 3 0 0 3 3 3 0 Desulfoferrodoxin, N-terminal domain LBP_BPI_CETP PF01273.25 CDW51829.1 - 0.17 11.5 0.0 0.21 11.2 0.0 1.1 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain G-alpha PF00503.20 CDW51830.1 - 4.3e-122 407.7 0.1 4.9e-122 407.5 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CDW51830.1 - 5.2e-18 65.1 0.3 3.2e-13 49.5 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW51830.1 - 0.00047 19.6 0.8 0.15 11.4 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CDW51830.1 - 0.00089 19.5 0.2 1.6 9.0 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 CDW51830.1 - 0.003 17.0 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein MMR_HSR1 PF01926.23 CDW51830.1 - 0.069 13.2 0.1 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CDW51830.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PAN_1 PF00024.26 CDW51831.1 - 2e-37 127.0 34.6 3.9e-13 49.2 7.3 4.3 4 0 0 4 4 4 4 PAN domain PAN_4 PF14295.6 CDW51831.1 - 0.0095 15.8 0.2 0.0095 15.8 0.2 4.5 4 1 0 4 4 4 2 PAN domain PAN_3 PF08277.12 CDW51831.1 - 0.57 10.0 20.8 0.031 14.1 1.1 4.7 5 0 0 5 5 5 0 PAN-like domain zf-H2C2_2 PF13465.6 CDW51833.1 - 1.1e-25 88.8 41.0 5.8e-08 32.8 2.2 5.8 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 CDW51833.1 - 2.2e-17 62.5 51.7 0.00057 20.2 5.2 6.1 5 0 0 5 5 5 5 Zinc finger, C2H2 type Homeodomain PF00046.29 CDW51833.1 - 4.3e-16 58.5 2.3 9e-16 57.5 1.1 2.2 2 0 0 2 2 1 1 Homeodomain zf-C2H2_4 PF13894.6 CDW51833.1 - 1.3e-09 38.0 48.2 0.012 16.4 3.6 6.3 5 0 0 5 5 5 5 C2H2-type zinc finger Homeobox_KN PF05920.11 CDW51833.1 - 2.5e-05 24.1 0.1 9.5e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 Homeobox KN domain zf-met PF12874.7 CDW51833.1 - 6.4e-05 23.2 36.1 0.016 15.6 1.7 6.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW51833.1 - 9.4e-05 22.6 40.3 0.018 15.3 0.5 6.3 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW51833.1 - 0.0016 18.4 42.5 0.0023 17.9 1.2 5.9 5 0 0 5 5 5 3 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 CDW51833.1 - 0.11 13.2 14.6 2.3 9.0 0.6 3.4 2 1 1 3 3 3 0 zinc-ribbon family DUF2197 PF09963.9 CDW51833.1 - 0.12 12.6 8.7 0.51 10.6 0.6 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) zinc_ribbon_9 PF14369.6 CDW51833.1 - 0.21 11.9 4.9 0.6 10.4 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon zf_UBZ PF18439.1 CDW51833.1 - 0.47 10.1 25.3 2 8.1 0.7 5.6 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 CDW51833.1 - 0.79 9.8 11.2 0.23 11.5 0.5 3.0 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_8 PF15909.5 CDW51833.1 - 0.91 9.9 21.2 0.66 10.3 1.4 3.4 3 1 1 4 4 3 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 CDW51833.1 - 1.5 9.0 21.0 0.13 12.4 3.1 4.4 3 1 1 4 4 4 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 CDW51833.1 - 2.5 7.9 19.8 8.3 6.3 0.8 4.5 4 0 0 4 4 4 0 zinc-finger C2H2-type Band_7 PF01145.25 CDW51837.1 - 5.8e-11 42.7 0.1 7.3e-11 42.4 0.1 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family 7tm_1 PF00001.21 CDW51838.1 - 5e-36 124.4 33.8 6.9e-36 123.9 33.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 CDW51838.1 - 0.00019 20.9 33.4 0.0003 20.2 33.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Imm_superinfect PF14373.6 CDW51838.1 - 1.4 8.9 0.0 1.4 8.9 0.0 3.8 3 1 1 4 4 4 0 Superinfection immunity protein PPI_Ypi1 PF07491.11 CDW51839.1 - 1.8e-21 75.7 1.3 3e-21 75.0 1.3 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor Collagen PF01391.18 CDW51840.1 - 3e-209 677.0 725.4 8.5e-10 38.2 20.4 30.1 4 4 23 27 27 27 25 Collagen triple helix repeat (20 copies) C4 PF01413.19 CDW51840.1 - 3.1e-80 265.8 2.6 1.8e-41 141.0 0.3 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Endonuclease_NS PF01223.23 CDW51841.1 - 2.5e-57 194.3 0.1 2.7e-57 194.2 0.1 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.6 CDW51841.1 - 0.038 14.1 0.7 0.19 11.8 0.7 1.9 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease Pkinase_Tyr PF07714.17 CDW51844.1 - 3.2e-63 213.4 0.0 3.1e-51 174.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDW51844.1 - 1.6e-28 99.8 0.0 9.9e-19 67.7 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain SH2 PF00017.24 CDW51844.1 - 8.8e-19 67.4 0.0 2.3e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 SH2 domain F_actin_bind PF08919.10 CDW51844.1 - 5.2e-17 61.9 2.3 1.1e-16 60.8 2.3 1.6 1 0 0 1 1 1 1 F-actin binding Haspin_kinase PF12330.8 CDW51844.1 - 0.059 12.3 7.4 0.11 11.4 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain SH3_2 PF07653.17 CDW51844.1 - 0.12 12.1 0.0 0.33 10.7 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain WD40 PF00400.32 CDW51845.1 - 5.7e-27 93.4 13.4 9.6e-07 29.4 0.6 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW51845.1 - 2.8e-08 33.9 0.5 0.031 14.5 0.0 4.9 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW51845.1 - 0.00012 21.6 0.0 0.0009 18.7 0.0 2.2 2 1 0 2 2 2 1 WD40-like domain Ribosomal_S14 PF00253.21 CDW51846.1 - 3.3e-19 68.4 1.5 1.2e-18 66.6 0.3 2.1 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Renin_r PF07850.14 CDW51847.1 - 5.6e-24 84.6 0.2 7.9e-24 84.1 0.2 1.3 1 1 0 1 1 1 1 Renin receptor-like protein P5CR_dimer PF14748.6 CDW51848.1 - 3.4e-33 114.0 3.0 6.6e-33 113.1 3.0 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CDW51848.1 - 3.2e-13 50.1 2.4 7.5e-08 32.9 0.0 2.7 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 CDW51848.1 - 0.00012 22.1 0.5 0.00021 21.3 0.5 1.5 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus MoCF_biosynth PF00994.24 CDW51849.1 - 1.1e-28 99.8 0.0 1.5e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_N PF03453.17 CDW51849.1 - 1e-14 54.6 0.1 1.6e-09 37.7 0.0 2.2 1 1 1 2 2 2 2 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 CDW51849.1 - 5.3e-06 26.5 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) Motile_Sperm PF00635.26 CDW51850.1 - 7e-11 41.9 0.1 1.3e-10 41.0 0.1 1.4 1 1 0 1 1 1 1 MSP (Major sperm protein) domain 7tm_1 PF00001.21 CDW51851.1 - 2.8e-13 49.8 25.3 4.4e-13 49.2 25.3 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CYYR1 PF10873.8 CDW51851.1 - 0.23 11.9 1.3 0.54 10.7 1.3 1.7 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 UCH_1 PF13423.6 CDW51852.1 - 3.7e-46 158.2 4.5 7e-29 101.4 0.3 2.2 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 CDW51852.1 - 7.8e-09 36.3 0.0 1.5e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 CDW51852.1 - 5.2e-07 29.4 0.0 3.4e-06 26.7 0.0 2.0 1 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase TMEM72 PF16054.5 CDW51852.1 - 0.027 14.2 0.7 0.059 13.1 0.7 1.5 1 0 0 1 1 1 0 Transmembrane protein family 72 7TM_GPCR_Srw PF10324.9 CDW51853.1 - 3.2e-09 36.5 0.9 4.1e-09 36.2 0.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW51853.1 - 5.3e-06 26.0 1.4 6.9e-06 25.6 1.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 CDW51853.1 - 0.0022 17.2 2.5 0.003 16.7 2.5 1.3 1 1 0 1 1 1 1 Taste receptor protein (TAS2R) HisKA_7TM PF16927.5 CDW51853.1 - 0.0025 17.9 4.5 0.0045 17.1 3.8 1.6 1 1 0 1 1 1 1 N-terminal 7TM region of histidine kinase CBP_BcsF PF11120.8 CDW51853.1 - 0.066 13.3 1.0 0.15 12.2 0.3 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF HSP20 PF00011.21 CDW51856.1 - 1.6e-19 69.9 0.1 2.1e-19 69.6 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family dsrm PF00035.26 CDW51857.1 - 0.00094 19.9 0.1 0.0012 19.6 0.1 1.2 1 0 0 1 1 1 1 Double-stranded RNA binding motif DUF3402 PF11882.8 CDW51858.1 - 1.4e-61 209.1 16.2 1.4e-35 123.3 7.9 3.0 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 CDW51858.1 - 2.4e-39 135.2 0.1 4.3e-39 134.4 0.1 1.4 1 0 0 1 1 1 1 N1221-like protein HEAT PF02985.22 CDW51858.1 - 0.14 12.5 1.4 0.49 10.8 0.2 2.8 2 0 0 2 2 2 0 HEAT repeat RRM_5 PF13893.6 CDW51859.1 - 3.2e-34 117.2 2.7 1e-20 73.6 0.0 4.2 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 CDW51859.1 - 6.2e-25 86.8 0.4 9.5e-07 28.6 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 CDW51859.1 - 3.8e-10 39.8 0.0 1.1e-09 38.3 0.0 1.8 2 0 0 2 2 2 1 RRM-like domain RRM_occluded PF16842.5 CDW51859.1 - 2e-08 34.0 0.7 0.67 9.9 0.0 4.6 5 0 0 5 5 5 3 Occluded RNA-recognition motif RRM_3 PF08777.11 CDW51859.1 - 0.0083 16.2 0.0 3.5 7.7 0.0 2.8 3 0 0 3 3 3 2 RNA binding motif DUF5611 PF18446.1 CDW51859.1 - 0.13 13.1 0.0 18 6.2 0.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5611) Serglycin PF04360.12 CDW51859.1 - 0.15 12.0 1.1 0.4 10.6 1.1 1.6 1 0 0 1 1 1 0 Serglycin LIM PF00412.22 CDW51860.1 - 2.5e-06 27.6 6.7 4.1e-06 26.9 6.7 1.3 1 0 0 1 1 1 1 LIM domain TNFR_c6 PF00020.18 CDW51860.1 - 0.14 12.5 4.8 0.52 10.8 0.7 2.4 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region IRS PF02174.17 CDW51861.1 - 8.4e-15 54.5 0.1 2e-14 53.3 0.1 1.6 1 1 0 1 1 1 1 PTB domain (IRS-1 type) Ras PF00071.22 CDW51862.1 - 1.6e-61 206.7 0.2 1.8e-61 206.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW51862.1 - 6.3e-35 120.0 0.1 1.1e-34 119.2 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW51862.1 - 3.5e-13 49.4 0.0 4.5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW51862.1 - 5.5e-05 23.2 0.0 8.5e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW51862.1 - 0.0001 21.8 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDW51862.1 - 0.00012 22.0 1.1 0.36 10.7 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CDW51862.1 - 0.00099 18.7 0.1 0.0025 17.4 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDW51862.1 - 0.013 15.9 0.0 0.023 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain MCR_beta PF02241.18 CDW51862.1 - 0.072 12.7 0.2 0.095 12.3 0.2 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain AAA_22 PF13401.6 CDW51862.1 - 0.095 13.0 0.1 1.8 8.8 0.0 2.2 1 1 0 2 2 2 0 AAA domain TniB PF05621.11 CDW51862.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 CDW51862.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Zona_pellucida PF00100.23 CDW51863.1 - 8.2e-11 42.2 6.5 1.1e-10 41.8 6.5 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain Syntaxin_2 PF14523.6 CDW51865.1 - 0.01 16.2 0.4 0.28 11.6 0.0 2.4 2 1 0 2 2 2 0 Syntaxin-like protein AAA_23 PF13476.6 CDW51865.1 - 0.088 13.3 2.7 0.12 12.9 2.7 1.2 1 0 0 1 1 1 0 AAA domain CENP-H PF05837.12 CDW51865.1 - 0.56 10.6 7.6 3.1 8.2 0.5 2.9 3 0 0 3 3 3 0 Centromere protein H (CENP-H) DivIC PF04977.15 CDW51865.1 - 3 7.7 10.5 3.4 7.5 0.6 3.8 4 0 0 4 4 4 0 Septum formation initiator LRR_8 PF13855.6 CDW51866.1 - 8.3e-52 172.8 37.3 5.8e-15 54.8 2.3 6.5 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 CDW51866.1 - 5.3e-25 87.1 40.0 0.00098 19.5 0.4 8.5 4 2 4 9 9 9 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW51866.1 - 2.7e-22 79.1 0.0 5.6e-10 39.3 0.0 4.1 2 1 3 5 5 5 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 CDW51866.1 - 7.7e-09 35.3 15.0 0.00088 18.8 1.4 3.9 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 CDW51866.1 - 5.7e-07 29.2 27.6 3.2 8.7 0.0 11.1 12 0 0 12 12 10 1 Leucine Rich Repeat TMEM154 PF15102.6 CDW51866.1 - 1.7e-05 24.7 0.4 3.7e-05 23.7 0.4 1.5 1 0 0 1 1 1 1 TMEM154 protein family DUF3377 PF11857.8 CDW51866.1 - 8.9e-05 22.3 0.3 0.00017 21.4 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) DUF1180 PF06679.12 CDW51866.1 - 0.0012 19.2 1.0 0.0022 18.4 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) LRR_6 PF13516.6 CDW51866.1 - 0.0035 17.3 21.7 18 5.7 0.1 8.5 8 0 0 8 8 7 0 Leucine Rich repeat Shisa PF13908.6 CDW51866.1 - 0.0078 16.5 0.7 0.015 15.5 0.7 1.5 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF4064 PF13273.6 CDW51866.1 - 0.017 15.4 0.1 0.034 14.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) EphA2_TM PF14575.6 CDW51866.1 - 0.02 15.7 0.3 0.058 14.3 0.3 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CD34_antigen PF06365.12 CDW51866.1 - 0.04 13.5 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Tmemb_9 PF05434.11 CDW51866.1 - 0.041 13.8 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 TMEM9 ECSCR PF15820.5 CDW51866.1 - 0.062 13.1 0.2 1.7 8.5 0.2 2.4 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Orf78 PF06024.12 CDW51866.1 - 0.073 13.4 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 Orf78 (ac78) DUF5305 PF17231.2 CDW51866.1 - 0.11 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) TRP PF06011.12 CDW51866.1 - 0.12 11.0 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Ly49 PF08391.10 CDW51866.1 - 0.17 12.3 0.9 0.35 11.3 0.9 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region SRTM1 PF15872.5 CDW51866.1 - 0.35 11.0 4.4 0.37 11.0 2.4 2.0 1 1 1 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 DUF2076 PF09849.9 CDW51866.1 - 0.56 10.2 3.2 0.95 9.5 3.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Baculo_11_kDa PF06143.11 CDW51866.1 - 0.69 9.5 3.5 1.9 8.1 3.5 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family IMUP PF15761.5 CDW51866.1 - 5.7 7.7 7.8 12 6.7 7.8 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein RhoGAP PF00620.27 CDW51867.1 - 2.8e-35 121.4 0.0 6.1e-35 120.3 0.0 1.6 1 1 0 1 1 1 1 RhoGAP domain Pkinase PF00069.25 CDW51868.1 - 2.2e-31 109.2 0.0 2.6e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW51868.1 - 1.3e-15 57.4 0.0 1.7e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TSC22 PF01166.18 CDW51869.1 - 8.5e-16 58.0 3.4 1.2e-15 57.6 3.4 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family IFP_35_N PF07334.13 CDW51869.1 - 0.038 14.1 0.3 0.072 13.2 0.3 1.5 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus betaPIX_CC PF16523.5 CDW51869.1 - 0.048 13.5 0.2 0.064 13.1 0.2 1.3 1 0 0 1 1 1 0 betaPIX coiled coil Phasin PF05597.11 CDW51869.1 - 0.058 13.4 0.6 0.084 12.9 0.6 1.2 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF2443 PF10398.9 CDW51869.1 - 0.069 13.2 0.2 0.11 12.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) YabA PF06156.13 CDW51869.1 - 0.073 13.7 0.2 0.12 13.0 0.2 1.4 1 0 0 1 1 1 0 Initiation control protein YabA LPP PF04728.13 CDW51869.1 - 0.095 13.1 0.5 4.7 7.7 0.0 2.2 2 0 0 2 2 2 0 Lipoprotein leucine-zipper NUDE_C PF04880.13 CDW51869.1 - 1.1 9.8 3.9 2.6 8.5 0.5 2.0 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region DAO PF01266.24 CDW51870.1 - 1e-52 179.9 0.0 1.6e-52 179.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T PF01571.21 CDW51870.1 - 1e-46 159.4 0.0 1.2e-45 156.0 0.0 2.1 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain FAO_M PF16350.5 CDW51870.1 - 3.2e-08 33.8 0.1 7.6e-08 32.6 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Thi4 PF01946.17 CDW51870.1 - 7.2e-05 22.1 0.2 0.00013 21.3 0.2 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CDW51870.1 - 0.0013 18.9 1.3 0.0028 17.8 1.3 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CDW51870.1 - 0.0029 16.9 0.1 0.0053 16.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDW51870.1 - 0.0032 16.6 0.1 0.0077 15.4 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 CDW51870.1 - 0.012 14.9 0.2 0.29 10.3 0.3 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDW51870.1 - 0.016 15.2 0.2 0.036 14.1 0.2 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding ApbA PF02558.16 CDW51870.1 - 0.039 13.6 1.0 0.08 12.6 1.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 CDW51870.1 - 0.04 14.0 0.1 0.11 12.5 0.2 1.7 2 0 0 2 2 1 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.7 CDW51870.1 - 0.046 13.1 0.1 0.066 12.5 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CDW51870.1 - 0.06 13.9 1.0 0.12 12.9 1.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDW51870.1 - 0.15 11.0 0.2 0.24 10.4 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein TBP PF00352.21 CDW51871.1 - 8.9e-60 198.6 0.3 3e-29 100.8 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) TspO_MBR PF03073.15 CDW51872.1 - 2.5e-40 137.7 14.0 3e-40 137.4 14.0 1.0 1 0 0 1 1 1 1 TspO/MBR family DnaJ_C PF01556.18 CDW51873.1 - 1.8e-39 135.2 0.4 2.6e-39 134.7 0.4 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDW51873.1 - 3.7e-26 91.0 0.6 5.9e-26 90.4 0.6 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDW51873.1 - 2.1e-15 56.8 15.2 3.7e-15 56.0 15.2 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CDW51873.1 - 0.00018 21.4 16.2 0.00067 19.6 0.4 4.3 5 1 1 6 6 6 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CDW51873.1 - 0.0011 18.9 6.1 0.44 10.6 0.3 2.5 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 CDW51873.1 - 0.0082 15.8 7.2 0.078 12.6 1.0 2.3 1 1 1 2 2 2 2 Thaumarchaeal output domain 1 CxC3 PF18804.1 CDW51873.1 - 0.08 12.8 0.6 0.17 11.7 0.6 1.5 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases Lar_restr_allev PF14354.6 CDW51873.1 - 0.16 12.4 5.2 20 5.7 1.3 3.4 2 1 1 3 3 3 0 Restriction alleviation protein Lar zf-C4_Topoisom PF01396.19 CDW51873.1 - 2.2 8.1 7.5 6 6.7 0.2 3.5 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger zinc-ribbons_6 PF07191.12 CDW51873.1 - 4.1 7.4 11.2 3.4e+02 1.3 11.2 2.4 1 1 0 1 1 1 0 zinc-ribbons WD40 PF00400.32 CDW51874.1 - 4.7e-55 182.3 9.9 5.2e-09 36.6 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW51874.1 - 2.5e-18 66.2 0.0 0.025 14.9 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW51874.1 - 3.6e-10 39.1 3.9 0.0012 17.6 0.0 5.6 2 1 4 6 6 6 3 Nucleoporin Nup120/160 eIF2A PF08662.11 CDW51874.1 - 3.7e-09 36.7 0.0 0.00013 21.9 0.0 3.9 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDW51874.1 - 1.9e-07 30.3 0.9 0.032 13.2 0.0 4.6 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 CDW51874.1 - 9.4e-06 24.2 0.0 0.002 16.5 0.0 2.7 1 1 2 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 CDW51874.1 - 0.00074 18.9 0.0 0.04 13.2 0.0 2.4 1 1 1 2 2 2 1 WD40-like domain RAB3GAP2_N PF14655.6 CDW51874.1 - 0.013 14.8 0.0 0.32 10.2 0.0 2.7 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PALB2_WD40 PF16756.5 CDW51874.1 - 0.016 14.2 0.9 0.8 8.6 0.0 2.9 1 1 2 3 3 3 0 Partner and localizer of BRCA2 WD40 domain potato_inhibit PF00280.18 CDW51874.1 - 0.02 15.6 0.0 6.8 7.4 0.0 2.4 2 0 0 2 2 2 0 Potato inhibitor I family Nbas_N PF15492.6 CDW51874.1 - 0.049 13.0 0.4 8.8 5.6 0.0 3.5 2 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Kelch_6 PF13964.6 CDW51874.1 - 1.4 9.3 6.1 21 5.6 0.0 4.3 5 1 0 5 5 4 0 Kelch motif tRNA-synt_2 PF00152.20 CDW51875.1 - 7.1e-200 662.6 0.0 1.8e-99 332.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDW51875.1 - 4.4e-22 77.9 0.0 1.5e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 OB-fold nucleic acid binding domain DUF4539 PF15072.6 CDW51875.1 - 0.0004 20.4 0.0 0.039 14.0 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4539) DUF2199 PF09965.9 CDW51875.1 - 0.00059 19.9 2.1 0.27 11.3 0.2 2.4 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2199) Mito_fiss_reg PF05308.11 CDW51875.1 - 0.0047 17.0 0.0 5.2 7.1 0.0 2.5 2 0 0 2 2 2 2 Mitochondrial fission regulator Ish1 PF10281.9 CDW51875.1 - 0.03 14.6 1.4 16 5.9 0.1 3.3 4 0 0 4 4 4 0 Putative stress-responsive nuclear envelope protein tRNA_anti_2 PF13742.6 CDW51875.1 - 0.032 14.4 0.0 8.2 6.7 0.0 2.5 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain HLH PF00010.26 CDW51877.1 - 2.1e-10 40.4 1.7 3.6e-10 39.6 1.7 1.5 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Myelin_PLP PF01275.19 CDW51878.1 - 9.5e-45 153.3 21.8 1.1e-44 153.1 21.8 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DUF554 PF04474.12 CDW51878.1 - 0.0036 16.8 5.1 0.0063 16.0 5.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF554) PRT_C PF08372.10 CDW51878.1 - 0.32 10.7 3.6 0.24 11.2 1.6 1.8 1 1 1 2 2 2 0 Plant phosphoribosyltransferase C-terminal Comm PF15957.5 CDW51878.1 - 0.76 10.1 4.0 0.63 10.4 2.2 1.9 1 1 0 1 1 1 0 Commissureless DUF4006 PF13179.6 CDW51878.1 - 2.2 8.3 0.0 2.2 8.3 0.0 3.3 3 2 1 4 4 4 0 Family of unknown function (DUF4006) DUF973 PF06157.11 CDW51878.1 - 3.2 6.7 12.0 7.5 5.5 8.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF973) Nop PF01798.18 CDW51879.1 - 1.6e-77 260.1 0.3 2.7e-77 259.3 0.3 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CDW51879.1 - 0.00016 22.0 0.0 0.00054 20.3 0.0 2.0 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Frizzled PF01534.17 CDW51880.1 - 9.6e-123 409.4 12.6 2.1e-122 408.2 12.6 1.5 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 CDW51880.1 - 1.6e-32 112.4 3.4 3.7e-32 111.3 3.4 1.6 1 0 0 1 1 1 1 Fz domain Dicty_CAR PF05462.11 CDW51880.1 - 0.004 16.3 5.6 0.0083 15.3 5.6 1.5 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor PAP1 PF08601.10 CDW51880.1 - 0.79 9.4 2.9 1.3 8.6 2.9 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 SR-25 PF10500.9 CDW51880.1 - 3.1 7.4 7.5 5.3 6.6 7.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ldl_recept_b PF00058.17 CDW51881.1 - 4.6e-22 78.2 3.1 1.1e-06 29.0 0.0 6.0 6 0 0 6 6 6 4 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 CDW51881.1 - 1.3e-12 47.7 24.1 3.3e-07 30.4 8.1 2.9 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 CDW51881.1 - 1.3e-11 44.5 19.1 4.7e-09 36.4 7.4 3.3 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 CDW51881.1 - 8.7e-08 32.2 1.9 8.7e-08 32.2 1.9 4.6 3 1 0 3 3 3 1 Calcium-binding EGF domain SGL PF08450.12 CDW51881.1 - 0.0034 17.0 0.2 0.51 9.9 0.1 3.4 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 CDW51881.1 - 0.01 15.7 0.2 0.01 15.7 0.2 4.2 5 0 0 5 5 5 0 Complement Clr-like EGF-like EGF PF00008.27 CDW51881.1 - 0.012 15.9 2.6 0.012 15.9 2.6 3.6 4 1 0 4 4 4 0 EGF-like domain DUF2684 PF10885.8 CDW51882.1 - 1.5 9.0 4.5 1.5 9.0 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2684) Fer2 PF00111.27 CDW51883.1 - 2.3e-08 33.9 0.6 3.9e-08 33.1 0.6 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain MCR PF18509.1 CDW51883.1 - 0.089 12.4 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Magnetochrome domain DHHC PF01529.20 CDW51884.1 - 2.7e-17 63.1 16.3 2.7e-17 63.1 16.3 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF4131 PF13567.6 CDW51884.1 - 0.068 12.8 0.1 0.089 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF1634 PF07843.11 CDW51884.1 - 0.1 12.7 4.5 0.13 12.3 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) C1_1 PF00130.22 CDW51884.1 - 0.15 11.9 16.4 0.21 11.5 16.4 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Flp1_like PF16982.5 CDW51884.1 - 1.8 8.1 6.1 1.3 8.5 1.6 2.2 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain Herpes_LMP1 PF05297.11 CDW51884.1 - 2.8 7.0 4.5 3.6 6.7 4.5 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Sec20 PF03908.13 CDW51885.1 - 0.02 14.8 0.3 0.07 13.0 0.3 2.1 2 0 0 2 2 2 0 Sec20 Phenol_Hydrox PF02332.18 CDW51885.1 - 0.03 13.8 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 Methane/Phenol/Toluene Hydroxylase PIN_2 PF10130.9 CDW51885.1 - 0.037 14.3 0.8 0.13 12.5 0.2 2.0 2 0 0 2 2 2 0 PIN domain BALF1 PF06861.11 CDW51885.1 - 0.093 12.4 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 BALF1 protein Importin_rep_6 PF18829.1 CDW51885.1 - 0.14 12.3 3.2 0.5 10.5 3.2 1.9 1 1 0 1 1 1 0 Importin repeat 6 Macoilin PF09726.9 CDW51886.1 - 1.5e-180 602.1 35.9 5.3e-180 600.3 35.9 1.9 1 1 0 1 1 1 1 Macoilin family YusW PF14039.6 CDW51886.1 - 1.7 9.2 7.7 0.12 12.9 0.4 2.3 2 0 0 2 2 2 0 YusW-like protein TFIIA PF03153.13 CDW51886.1 - 1.8 8.4 22.0 2.9 7.8 22.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FapA PF03961.13 CDW51886.1 - 4.6 5.7 14.7 1.6 7.3 3.2 2.2 2 0 0 2 2 2 0 Flagellar Assembly Protein A G-alpha PF00503.20 CDW51887.1 - 1.4e-115 386.3 0.3 1.6e-115 386.1 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CDW51887.1 - 6.5e-15 55.0 2.6 4e-11 42.7 0.3 3.4 3 1 0 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW51887.1 - 0.00012 21.5 1.7 0.0098 15.3 0.0 2.6 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CDW51887.1 - 0.029 14.6 1.3 3.7 7.8 0.3 2.8 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CDW51887.1 - 0.098 12.7 0.0 11 6.1 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW51887.1 - 0.15 11.9 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase DUF3480 PF11979.8 CDW51888.1 - 1.8e-81 273.9 0.0 2.1e-81 273.6 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) FYVE PF01363.21 CDW51889.1 - 1.8e-19 69.6 14.3 3.6e-19 68.7 14.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger SBP PF03110.14 CDW51889.1 - 0.6 10.4 16.6 7.7 6.9 9.9 2.4 1 1 1 2 2 2 0 SBP domain zf-MYND PF01753.18 CDW51890.1 - 6 7.1 9.8 12 6.1 2.4 3.1 2 1 1 3 3 3 0 MYND finger Pkinase_Tyr PF07714.17 CDW51891.1 - 1.2e-63 214.8 0.0 2e-63 214.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW51891.1 - 2.5e-61 207.3 0.0 5.1e-61 206.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CDW51891.1 - 0.00014 20.7 0.1 0.0016 17.3 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CDW51891.1 - 0.00068 19.0 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDW51891.1 - 0.0023 17.9 0.3 0.0063 16.5 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDW51891.1 - 0.0025 17.4 0.8 0.0041 16.7 0.1 1.8 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 CDW51891.1 - 0.0059 16.0 0.1 0.013 14.9 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDW51891.1 - 0.047 12.6 0.7 0.13 11.2 0.0 1.9 2 1 0 2 2 2 0 Haspin like kinase domain Sen15 PF09631.10 CDW51892.1 - 0.092 13.1 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Sen15 protein Phos_pyr_kin PF08543.12 CDW51893.1 - 5.4e-14 52.2 0.0 8.6e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CDW51893.1 - 1.1e-06 28.2 0.1 4.2e-05 23.0 0.0 2.6 3 0 0 3 3 3 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 CDW51893.1 - 0.0048 16.4 0.0 0.0068 15.9 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate kinase DAGK_acc PF00609.19 CDW51895.1 - 4.6e-45 153.8 0.0 3.1e-44 151.1 0.0 2.1 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 CDW51895.1 - 2.3e-26 91.9 0.0 3.6e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 CDW51895.1 - 5.4e-10 39.0 27.8 2.9e-09 36.7 13.1 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DOMON PF03351.17 CDW51896.1 - 2.9e-64 214.9 15.8 2.6e-21 76.1 0.4 6.5 6 1 0 6 6 6 3 DOMON domain CD34_antigen PF06365.12 CDW51896.1 - 0.016 14.8 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 CD34/Podocalyxin family Fig1 PF12351.8 CDW51896.1 - 0.024 14.6 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 MMR_HSR1_Xtn PF16897.5 CDW51896.1 - 0.053 13.5 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TMEM154 PF15102.6 CDW51896.1 - 0.065 13.1 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 TMEM154 protein family ABC2_membrane_3 PF12698.7 CDW51896.1 - 0.11 11.5 0.3 0.18 10.9 0.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein SpdB PF05122.13 CDW51896.1 - 2 8.6 6.5 8.8 6.6 0.4 2.9 2 0 0 2 2 2 0 Mobile element transfer protein PX PF00787.24 CDW51897.1 - 1.2e-19 70.4 0.5 2.6e-18 66.0 0.7 2.3 2 0 0 2 2 2 1 PX domain PDZ_6 PF17820.1 CDW51897.1 - 1.3e-15 57.0 1.3 4.7e-15 55.2 0.6 2.4 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDW51897.1 - 2.1e-12 47.2 1.2 5.1e-12 46.0 1.2 1.7 1 0 0 1 1 1 1 PDZ domain Dynactin_p22 PF07426.11 CDW51897.1 - 9e-07 28.9 2.4 1.9e-06 27.8 2.4 1.6 1 0 0 1 1 1 1 Dynactin subunit p22 RA PF00788.23 CDW51897.1 - 9.5e-07 29.4 0.0 2.5e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ_2 PF13180.6 CDW51897.1 - 0.00018 21.8 0.5 0.00065 20.0 0.1 2.0 2 1 1 3 3 3 1 PDZ domain YlbE PF14003.6 CDW51897.1 - 0.019 15.4 0.3 0.046 14.2 0.3 1.6 1 0 0 1 1 1 0 YlbE-like protein FERM_M PF00373.18 CDW51897.1 - 0.057 13.8 0.2 0.4 11.1 0.0 2.7 2 1 0 2 2 2 0 FERM central domain Pkinase_Tyr PF07714.17 CDW51898.1 - 1.3e-24 86.9 0.0 1.7e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW51898.1 - 5.8e-17 61.9 0.0 8.9e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW51898.1 - 1.9e-12 47.1 0.0 3.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 SH2 domain START PF01852.19 CDW51899.1 - 5.7e-15 55.3 0.0 7.7e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 START domain AAA PF00004.29 CDW51902.1 - 9.1e-55 184.7 0.0 5.5e-39 133.6 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW51902.1 - 2.5e-11 43.2 0.1 5.9e-11 42.0 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain CDC48_N PF02359.18 CDW51902.1 - 1.6e-08 34.6 0.0 1.5e-07 31.5 0.0 2.4 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA_22 PF13401.6 CDW51902.1 - 4e-08 33.6 0.1 0.0014 18.9 0.2 3.7 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.13 CDW51902.1 - 7.2e-08 32.0 0.0 0.0026 17.0 0.0 2.5 3 0 0 3 3 2 2 TIP49 P-loop domain AAA_18 PF13238.6 CDW51902.1 - 1.2e-07 32.3 0.0 0.03 14.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CDW51902.1 - 1.6e-07 31.4 0.5 0.0011 19.0 0.1 3.5 4 1 0 4 4 2 2 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDW51902.1 - 1.6e-07 31.2 0.0 0.012 15.3 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain CDC48_2 PF02933.17 CDW51902.1 - 3.7e-07 29.8 0.8 6.7e-06 25.8 0.1 2.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 CDW51902.1 - 3.8e-07 30.6 0.1 0.0091 16.4 0.0 3.0 2 2 0 2 2 2 2 AAA ATPase domain ATPase_2 PF01637.18 CDW51902.1 - 1.3e-06 28.5 0.9 0.66 9.8 0.0 4.4 3 2 1 5 5 4 1 ATPase domain predominantly from Archaea AAA_2 PF07724.14 CDW51902.1 - 2.2e-06 27.9 0.0 0.00029 21.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 CDW51902.1 - 9.1e-06 25.2 0.2 0.0073 15.7 0.1 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDW51902.1 - 1.8e-05 24.9 0.0 0.14 12.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 CDW51902.1 - 2.1e-05 24.5 0.0 0.12 12.4 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CDW51902.1 - 4.9e-05 23.3 0.1 2.8 7.8 0.0 4.2 3 1 1 4 4 4 2 NACHT domain RNA_helicase PF00910.22 CDW51902.1 - 6.6e-05 23.2 0.0 0.039 14.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_24 PF13479.6 CDW51902.1 - 0.00011 22.1 0.0 0.039 13.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 CDW51902.1 - 0.00012 21.5 0.0 0.0034 16.7 0.0 2.4 2 0 0 2 2 2 1 KaiC AAA_14 PF13173.6 CDW51902.1 - 0.00015 21.8 0.0 0.81 9.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 CDW51902.1 - 0.00025 20.9 0.0 0.2 11.5 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 CDW51902.1 - 0.00091 18.4 0.0 0.52 9.3 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 CDW51902.1 - 0.0015 18.1 0.0 0.031 13.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 CDW51902.1 - 0.0029 17.2 0.3 1.8 8.1 0.0 3.2 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 CDW51902.1 - 0.0033 17.2 0.0 0.2 11.4 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 CDW51902.1 - 0.0039 16.9 0.0 0.84 9.3 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_11 PF13086.6 CDW51902.1 - 0.0078 16.0 0.0 0.44 10.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CDW51902.1 - 0.0087 16.3 0.0 5.9 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.10 CDW51902.1 - 0.011 15.2 0.0 3.7 6.9 0.0 2.6 3 0 0 3 3 2 0 Chromatin associated protein KTI12 ABC_tran PF00005.27 CDW51902.1 - 0.012 16.1 0.0 0.12 12.9 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_17 PF13207.6 CDW51902.1 - 0.016 15.6 0.0 3.7 8.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDW51902.1 - 0.019 14.7 0.0 0.24 11.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDW51902.1 - 0.024 13.8 0.0 4.4 6.4 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain CPT PF07931.12 CDW51902.1 - 0.032 14.1 0.0 0.7 9.7 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 CDW51902.1 - 0.049 14.0 0.1 1.4 9.2 0.1 2.8 3 0 0 3 3 2 0 AAA domain Hydin_ADK PF17213.3 CDW51902.1 - 0.058 13.7 0.1 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain DCP1 PF06058.13 CDW51903.1 - 1e-24 86.7 0.0 1.7e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 Dcp1-like decapping family Pkinase PF00069.25 CDW51904.1 - 8.9e-15 54.8 0.0 1e-14 54.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW51904.1 - 1.8e-13 50.4 0.0 2.1e-13 50.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW51905.1 - 1e-19 71.0 0.0 1.6e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain PTEN_C2 PF10409.9 CDW51905.1 - 3.2e-11 43.1 0.0 5e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Pkinase_Tyr PF07714.17 CDW51905.1 - 6.6e-08 32.2 0.0 1.2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DnaJ PF00226.31 CDW51905.1 - 3.1e-05 24.0 0.0 8.7e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 DnaJ domain PCDO_beta_N PF12391.8 CDW51905.1 - 0.13 11.9 1.0 0.37 10.4 1.0 1.8 1 0 0 1 1 1 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal GPP34 PF05719.11 CDW51906.1 - 8.7e-57 192.4 0.9 8.7e-57 192.4 0.9 1.5 2 0 0 2 2 2 1 Golgi phosphoprotein 3 (GPP34) DUF2680 PF10925.8 CDW51906.1 - 0.064 13.3 0.1 12 6.0 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) Chitin_synth_2 PF03142.15 CDW51907.1 - 5.8e-31 107.7 4.0 3.3e-28 98.6 0.5 2.3 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CDW51907.1 - 5.5e-12 46.0 1.2 5.5e-12 46.0 1.2 3.6 4 0 0 4 4 4 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CDW51907.1 - 8e-06 25.9 0.0 1.8e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDW51907.1 - 0.0031 17.3 0.0 0.0073 16.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF4274 PF14096.6 CDW51908.1 - 0.031 14.2 0.0 9.6 6.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4274) WD40 PF00400.32 CDW51909.1 - 2.8e-05 24.8 0.2 0.4 11.7 0.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat C1_1 PF00130.22 CDW51910.1 - 1.8e-09 37.3 14.8 1.8e-09 37.3 13.5 1.7 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.30 CDW51910.1 - 1.4e-08 34.9 0.0 3.6e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain zf-RING_9 PF13901.6 CDW51910.1 - 0.001 19.1 5.7 0.0026 17.8 5.7 1.7 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon C1_2 PF03107.16 CDW51910.1 - 0.0015 18.8 8.0 0.0033 17.7 8.0 1.6 1 0 0 1 1 1 1 C1 domain PXA PF02194.15 CDW51910.1 - 0.019 15.0 1.4 0.16 12.0 0.1 2.6 2 1 1 3 3 3 0 PXA domain KIF1B PF12423.8 CDW51910.1 - 0.11 12.9 0.1 0.29 11.6 0.1 1.7 1 0 0 1 1 1 0 Kinesin protein 1B Zf_RING PF16744.5 CDW51910.1 - 1.6 8.9 7.1 4.1 7.6 7.1 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger Mt_ATP-synt_B PF05405.14 CDW51910.1 - 1.7 8.3 7.3 5 6.7 0.0 3.6 5 0 0 5 5 5 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Homeodomain PF00046.29 CDW51911.1 - 4.6e-20 71.2 8.1 7.3e-20 70.6 8.1 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW51911.1 - 0.047 13.6 0.8 0.12 12.4 0.8 1.6 1 0 0 1 1 1 0 Homeobox KN domain T2SS_PulS_OutS PF09691.10 CDW51911.1 - 0.073 13.3 0.3 0.13 12.4 0.3 1.5 1 0 0 1 1 1 0 Type II secretion system pilotin lipoprotein (PulS_OutS) Homez PF11569.8 CDW51911.1 - 0.078 12.5 0.1 0.14 11.6 0.1 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 CDW51911.1 - 0.16 11.9 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT EGF PF00008.27 CDW51912.1 - 2.4e-12 46.9 13.9 1.2e-08 35.1 2.7 2.4 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 CDW51912.1 - 4.1e-07 30.4 10.6 6.3e-05 23.5 2.0 3.3 2 1 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.13 CDW51912.1 - 0.00012 22.4 21.5 0.018 15.4 4.8 2.6 2 1 0 2 2 2 2 EGF-like domain EGF_CA PF07645.15 CDW51912.1 - 0.00014 22.0 4.4 0.00014 22.0 4.4 2.7 2 1 0 2 2 2 1 Calcium-binding EGF domain Laminin_EGF PF00053.24 CDW51912.1 - 0.08 13.1 17.8 1.4 9.1 9.1 2.2 1 1 1 2 2 2 0 Laminin EGF domain EGF_alliinase PF04863.13 CDW51912.1 - 1.3 9.4 17.2 0.52 10.8 9.3 2.6 2 2 0 2 2 2 0 Alliinase EGF-like domain EGF_3 PF12947.7 CDW51912.1 - 1.9 8.8 16.2 12 6.2 6.1 2.8 1 1 1 2 2 2 0 EGF domain EGF_Tenascin PF18720.1 CDW51912.1 - 4.1 7.6 14.7 0.69 10.0 0.5 3.1 2 2 0 2 2 2 0 Tenascin EGF domain Antimicrobial25 PF16839.5 CDW51912.1 - 6.9 6.8 18.1 3 8.0 6.2 2.4 1 1 1 2 2 2 0 Nematode antimicrobial peptide W2 PF02020.18 CDW51914.1 - 2.3e-18 66.1 1.4 5.6e-18 64.9 1.4 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 CDW51914.1 - 4.8e-11 41.9 17.1 0.0021 17.7 1.2 3.5 2 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 CDW51914.1 - 9e-05 21.6 0.6 0.00017 20.7 0.6 1.4 1 0 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 CDW51914.1 - 0.0042 16.8 21.3 0.032 14.0 5.2 3.5 2 1 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 CDW51914.1 - 0.11 10.6 4.5 0.19 9.8 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) PMM PF03332.13 CDW51915.1 - 2.1e-94 315.4 0.5 2.4e-94 315.2 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 CDW51915.1 - 1.3e-06 28.4 0.0 4.9e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW51915.1 - 0.039 14.2 0.0 0.045 14.0 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase G-alpha PF00503.20 CDW51916.1 - 2e-94 316.7 10.3 3.5e-93 312.6 10.3 1.9 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CDW51916.1 - 4.4e-11 42.5 0.6 7.4e-08 32.0 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW51916.1 - 0.0055 16.8 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW51916.1 - 0.03 13.7 1.2 0.7 9.2 0.1 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 CDW51916.1 - 0.04 13.6 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MCM PF00493.23 CDW51916.1 - 0.043 12.9 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain FtsK_SpoIIIE PF01580.18 CDW51916.1 - 0.056 12.8 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Snf7 PF03357.21 CDW51917.1 - 1.9e-15 56.9 12.5 3.4e-15 56.1 12.5 1.4 1 0 0 1 1 1 1 Snf7 DUF913 PF06025.12 CDW51917.1 - 0.0082 15.2 1.0 0.015 14.3 0.0 1.7 1 1 1 2 2 2 1 Domain of Unknown Function (DUF913) ESCRT-II PF05871.12 CDW51917.1 - 0.039 14.2 0.2 0.28 11.4 0.2 2.3 1 1 0 1 1 1 0 ESCRT-II complex subunit DUF1664 PF07889.12 CDW51917.1 - 4.1 7.5 9.5 15 5.7 2.7 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) LETM1 PF07766.13 CDW51918.1 - 7.2e-95 317.4 7.8 7.2e-95 317.4 7.8 2.6 3 0 0 3 3 3 1 LETM1-like protein ARL6IP6 PF15062.6 CDW51918.1 - 0.043 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix SpecificRecomb PF10136.9 CDW51918.1 - 0.064 11.6 3.0 0.14 10.5 3.0 1.6 1 0 0 1 1 1 0 Site-specific recombinase SFTA2 PF15210.6 CDW51918.1 - 0.19 11.7 2.9 17 5.4 0.6 2.7 2 0 0 2 2 2 0 Surfactant-associated protein 2 DASH_Duo1 PF08651.10 CDW51918.1 - 0.93 9.3 8.8 0.24 11.2 1.1 3.3 3 0 0 3 3 3 0 DASH complex subunit Duo1 Vta1 PF04652.16 CDW51919.1 - 6.1e-35 120.3 4.1 8.7e-35 119.8 1.4 2.0 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 CDW51919.1 - 3.5e-16 58.6 1.5 5.6e-16 57.9 0.6 1.8 2 0 0 2 2 2 1 Vta1 C-terminal domain FliS PF02561.14 CDW51919.1 - 0.093 13.0 0.7 0.95 9.8 0.1 2.5 2 1 1 3 3 3 0 Flagellar protein FliS VIR_N PF15912.5 CDW51919.1 - 0.3 10.6 2.1 0.19 11.3 0.4 1.4 2 0 0 2 2 2 0 Virilizer, N-terminal SKA1 PF07160.12 CDW51919.1 - 0.47 10.3 7.6 0.49 10.2 2.9 2.1 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 dCMP_cyt_deam_1 PF00383.23 CDW51920.1 - 7.5 6.5 12.6 10 6.0 4.0 2.5 2 1 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region UDPGT PF00201.18 CDW51921.1 - 2.2e-16 59.7 0.0 2.2e-16 59.7 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_3 PF13528.6 CDW51921.1 - 0.0044 16.3 0.0 0.0049 16.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl transferase family 1 RhoGAP PF00620.27 CDW51923.1 - 4.3e-46 156.5 0.2 1.8e-45 154.4 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain BAR PF03114.18 CDW51923.1 - 1.7e-22 80.2 11.5 2.8e-22 79.5 11.5 1.3 1 0 0 1 1 1 1 BAR domain ABC_tran_Xtn PF12848.7 CDW51923.1 - 0.29 11.2 1.8 1.2 9.2 1.8 2.0 1 0 0 1 1 1 0 ABC transporter YkyA PF10368.9 CDW51923.1 - 0.48 10.1 3.7 0.32 10.6 0.1 2.2 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Laminin_N PF00055.17 CDW51924.1 - 5.1e-68 229.2 0.0 5.1e-68 229.2 0.0 2.6 2 1 1 3 3 3 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 CDW51924.1 - 3.6e-25 87.9 61.5 5.3e-10 39.3 13.8 5.6 6 0 0 6 6 6 3 Laminin EGF domain NTR PF01759.21 CDW51924.1 - 8.2e-24 83.5 0.0 1.5e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 UNC-6/NTR/C345C module F5_F8_type_C PF00754.25 CDW51924.1 - 0.0005 20.2 0.0 0.00093 19.3 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain EF-hand_7 PF13499.6 CDW51927.1 - 7.5e-09 35.9 0.4 0.0059 17.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDW51927.1 - 1.4e-08 34.4 1.5 0.0011 18.7 0.2 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW51927.1 - 3.9e-08 32.6 2.2 0.001 18.8 0.4 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CDW51927.1 - 7.1e-08 31.5 4.1 0.00053 19.4 0.6 3.0 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 CDW51927.1 - 0.001 18.5 2.2 0.0099 15.3 0.3 2.7 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 CDW51927.1 - 0.0019 18.1 0.2 1.9 8.5 0.0 2.4 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand zf-C2H2_4 PF13894.6 CDW51928.1 - 1.4e-08 34.9 55.9 0.0026 18.5 2.5 8.1 8 0 0 8 8 8 5 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW51928.1 - 1.2e-07 31.8 63.6 0.018 15.4 3.8 8.4 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW51928.1 - 0.0004 20.7 66.9 0.032 14.7 4.6 9.6 10 0 0 10 10 10 4 Zinc-finger double domain zf-C2H2_12 PF18658.1 CDW51928.1 - 0.0042 16.6 14.1 0.55 9.8 0.9 3.9 4 0 0 4 4 4 3 Zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 CDW51928.1 - 0.0091 16.4 12.8 0.91 10.0 1.0 5.0 4 0 0 4 4 4 2 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_11 PF16622.5 CDW51928.1 - 0.099 12.4 0.2 0.099 12.4 0.2 4.2 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-Di19 PF05605.12 CDW51928.1 - 2.1 8.7 42.6 0.071 13.4 6.3 5.2 3 1 3 6 6 6 0 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 CDW51928.1 - 2.2 8.0 26.4 0.47 10.1 0.4 5.8 3 3 3 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_jaz PF12171.8 CDW51928.1 - 2.5 8.5 35.7 0.54 10.6 0.2 6.5 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding Erf4 PF10256.9 CDW51929.1 - 5.4e-29 100.7 0.0 6.2e-29 100.5 0.0 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Glyco_hydro_31 PF01055.26 CDW51930.1 - 6.1e-144 480.5 4.5 8.3e-144 480.0 4.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CDW51930.1 - 1.5e-23 82.9 0.9 6.9e-23 80.8 0.4 2.3 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 CDW51930.1 - 4.7e-09 36.4 0.9 2.2e-08 34.3 0.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) G-gamma PF00631.22 CDW51931.1 - 2.3e-13 49.9 0.6 6e-12 45.4 0.0 3.1 2 0 0 2 2 2 1 GGL domain MAP65_ASE1 PF03999.12 CDW51931.1 - 4.7e-11 42.1 17.1 2.4e-07 29.9 3.1 2.3 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) DUF2120 PF09893.9 CDW51931.1 - 2.7 8.1 6.4 1.7 8.8 0.0 3.3 2 1 2 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2120) Tubulin PF00091.25 CDW51932.1 - 6.6e-68 228.8 0.0 9.9e-68 228.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDW51932.1 - 8.6e-36 122.9 0.0 1.3e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDW51932.1 - 0.00049 19.8 0.0 0.00092 18.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 CDW51932.1 - 0.00066 19.0 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 CDW51932.1 - 0.00069 19.9 0.0 0.0013 19.0 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain KH_1 PF00013.29 CDW51934.1 - 0.00049 19.9 0.8 0.0011 18.8 0.3 1.8 2 0 0 2 2 2 1 KH domain EGF PF00008.27 CDW51935.1 - 9e-16 57.9 62.5 0.00025 21.3 2.9 5.7 5 0 0 5 5 5 5 EGF-like domain His_Phos_1 PF00300.22 CDW51935.1 - 3.4e-08 33.4 0.0 6.6e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) hEGF PF12661.7 CDW51935.1 - 2.2e-06 28.1 47.7 0.0021 18.6 2.4 6.4 6 0 0 6 6 6 4 Human growth factor-like EGF EGF_3 PF12947.7 CDW51935.1 - 0.0014 18.7 5.7 0.0014 18.7 5.7 5.7 5 0 0 5 5 5 4 EGF domain Laminin_EGF PF00053.24 CDW51935.1 - 0.0022 18.1 65.3 1.3 9.2 6.7 5.6 2 2 3 5 5 5 3 Laminin EGF domain EGF_2 PF07974.13 CDW51935.1 - 0.043 14.2 73.4 0.49 10.8 4.1 5.9 5 0 0 5 5 5 0 EGF-like domain DEAD PF00270.29 CDW51936.1 - 8.8e-37 126.5 0.2 1.5e-36 125.8 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW51936.1 - 3.8e-29 101.3 0.1 1.1e-28 99.8 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW51936.1 - 7.6e-06 26.0 0.0 1.8e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit WD40 PF00400.32 CDW51936.1 - 0.0022 18.8 0.7 4 8.5 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat CNH PF00780.22 CDW51936.1 - 0.021 14.4 0.0 0.072 12.7 0.0 1.9 2 0 0 2 2 2 0 CNH domain DNA_pol_B PF00136.21 CDW51937.1 - 3.3e-146 487.6 0.0 4.8e-146 487.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDW51937.1 - 1.2e-73 248.2 0.0 2e-73 247.5 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CDW51937.1 - 1.6e-17 63.7 9.4 3.9e-17 62.5 9.4 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 CDW51937.1 - 0.0027 16.7 0.0 0.0042 16.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral DUF2767 PF10965.8 CDW51937.1 - 0.084 12.9 0.5 4.7 7.3 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2767) Ion_trans_2 PF07885.16 CDW51938.1 - 1.6e-30 104.9 18.0 1.2e-16 60.4 8.8 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 CDW51938.1 - 0.52 9.5 8.6 20 4.3 6.9 2.4 2 1 0 2 2 2 0 Ion transport protein dsrm PF00035.26 CDW51939.1 - 5.5e-17 62.2 0.5 2.4e-06 28.2 0.0 4.1 3 1 0 3 3 3 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CDW51939.1 - 4.9e-07 29.9 1.7 0.28 11.4 0.0 4.0 3 1 0 3 3 3 3 double strand RNA binding domain from DEAD END PROTEIN 1 LPP20 PF02169.16 CDW51939.1 - 0.01 16.2 0.1 11 6.5 0.0 3.1 3 0 0 3 3 3 0 LPP20 lipoprotein Staufen_C PF16482.5 CDW51939.1 - 0.15 12.2 0.0 15 5.8 0.0 3.0 3 0 0 3 3 3 0 Staufen C-terminal domain Lipase_GDSL_2 PF13472.6 CDW51940.1 - 2.8e-13 50.7 0.0 6.7e-13 49.4 0.0 1.6 1 1 1 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDW51940.1 - 2.5e-06 27.6 0.0 2.1e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 CDW51940.1 - 0.01 16.0 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Kelch_6 PF13964.6 CDW51942.1 - 0.03 14.6 0.2 3 8.3 0.0 3.0 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 CDW51942.1 - 0.1 12.9 0.0 0.38 11.1 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain EGF_2 PF07974.13 CDW51944.1 - 1.4e-16 60.6 165.7 0.00047 20.5 6.2 9.6 10 0 0 10 10 10 8 EGF-like domain NHL PF01436.21 CDW51944.1 - 1.6e-07 31.0 0.3 1.5 9.0 0.0 6.9 6 0 0 6 6 6 2 NHL repeat EGF_Tenascin PF18720.1 CDW51944.1 - 0.0029 17.6 5.5 0.0029 17.6 5.5 9.0 8 0 0 8 8 8 6 Tenascin EGF domain RHS_repeat PF05593.14 CDW51944.1 - 0.012 16.1 0.2 0.94 10.1 0.0 3.1 3 0 0 3 3 3 0 RHS Repeat fn3 PF00041.21 CDW51945.1 - 1.4e-05 25.3 0.5 2.5e-05 24.5 0.5 1.5 1 0 0 1 1 1 1 Fibronectin type III domain DUF2369 PF10179.9 CDW51945.1 - 0.0016 18.8 0.0 0.0029 17.9 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 CDW51945.1 - 0.0044 17.6 0.7 0.012 16.1 0.7 1.9 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Cation_efflux PF01545.21 CDW51946.1 - 2.3e-50 171.1 8.0 3.2e-50 170.7 8.0 1.2 1 0 0 1 1 1 1 Cation efflux family NAP PF00956.18 CDW51947.1 - 2.4e-66 223.7 0.0 2.9e-66 223.4 0.0 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) NAP PF00956.18 CDW51948.1 - 4.2e-76 255.7 0.0 5.8e-76 255.2 0.0 1.2 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Tetraspanin PF00335.20 CDW51949.1 - 4.6e-18 65.8 1.5 6.2e-18 65.3 1.5 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF3681 PF12442.8 CDW51949.1 - 0.31 11.5 5.4 0.24 11.9 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3681) DUF4229 PF14012.6 CDW51949.1 - 0.34 11.0 4.5 0.84 9.8 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4229) Polysacc_synt_3 PF13440.6 CDW51949.1 - 1.4 8.0 7.0 0.058 12.6 0.6 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DUF1189 PF06691.11 CDW51949.1 - 1.8 8.1 8.4 0.25 10.9 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) AIF_C PF14721.6 CDW51950.1 - 1.1e-56 190.8 0.0 2.2e-56 189.8 0.0 1.5 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox_2 PF07992.14 CDW51950.1 - 3.5e-35 121.7 0.0 6.1e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDW51950.1 - 7.7e-07 29.6 0.0 2.9e-06 27.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Deltameth_res PF16020.5 CDW51950.1 - 0.0003 20.6 0.0 0.00072 19.4 0.0 1.6 1 0 0 1 1 1 1 Deltamethrin resistance Pyr_redox_3 PF13738.6 CDW51950.1 - 0.0054 16.0 0.0 0.024 13.9 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CDW51950.1 - 0.01 15.0 0.0 0.14 11.3 0.0 2.3 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Reductase_C PF14759.6 CDW51950.1 - 0.018 15.6 0.0 0.11 13.0 0.0 2.3 2 0 0 2 2 2 0 Reductase C-terminal GIDA PF01134.22 CDW51950.1 - 0.023 13.8 0.2 5.3 6.0 0.1 2.8 3 0 0 3 3 3 0 Glucose inhibited division protein A DAO PF01266.24 CDW51950.1 - 0.1 12.1 0.7 18 4.7 0.7 2.7 3 0 0 3 3 3 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDW51950.1 - 0.13 12.2 3.0 17 5.3 0.1 3.2 2 1 1 3 3 3 0 FAD-NAD(P)-binding WD40 PF00400.32 CDW51951.1 - 2.9e-32 110.2 1.7 0.00049 20.8 0.1 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW51951.1 - 5.6e-09 36.2 0.0 0.48 10.8 0.0 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW51951.1 - 6.2e-06 25.1 1.4 1.4 7.5 0.0 3.8 1 1 1 3 3 3 3 Nucleoporin Nup120/160 Hira PF07569.11 CDW51951.1 - 0.0058 16.4 0.2 0.8 9.4 0.0 2.6 1 1 1 2 2 2 2 TUP1-like enhancer of split WD40_like PF17005.5 CDW51951.1 - 0.012 15.0 0.0 0.045 13.1 0.0 2.1 1 1 0 1 1 1 0 WD40-like domain Frtz PF11768.8 CDW51951.1 - 0.025 12.9 0.1 0.15 10.3 0.0 1.9 1 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 CDW51951.1 - 0.091 11.8 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain zf-DBF PF07535.12 CDW51953.1 - 4.8e-06 26.6 0.8 1.8e-05 24.8 0.8 2.0 1 0 0 1 1 1 1 DBF zinc finger CNDH2_C PF16858.5 CDW51953.1 - 0.013 15.4 3.1 0.017 15.0 3.1 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Hira PF07569.11 CDW51954.1 - 0.13 12.0 0.0 0.43 10.3 0.0 1.8 2 0 0 2 2 2 0 TUP1-like enhancer of split zf-H2C2_2 PF13465.6 CDW51955.1 - 1.5e-33 113.7 45.4 8.1e-10 38.7 0.9 10.1 10 1 0 10 10 10 6 Zinc-finger double domain zf-C2H2 PF00096.26 CDW51955.1 - 2e-28 97.2 57.5 1.2e-05 25.5 0.2 9.6 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW51955.1 - 8e-23 79.2 61.1 0.00091 19.9 0.7 9.5 9 0 0 9 9 9 9 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW51955.1 - 7.8e-18 64.3 34.0 0.014 15.6 0.6 9.3 9 0 0 9 9 9 6 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW51955.1 - 1.9e-05 24.5 43.3 0.027 14.5 0.4 8.4 9 0 0 9 9 8 3 C2H2-type zinc finger zf-Di19 PF05605.12 CDW51955.1 - 0.00013 22.2 1.6 0.00013 22.2 1.6 6.5 5 2 1 6 6 6 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 CDW51955.1 - 0.00017 21.9 43.2 0.12 12.8 0.4 9.1 9 0 0 9 9 9 3 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 CDW51955.1 - 0.00055 20.6 25.5 0.019 15.7 2.7 6.6 1 1 4 6 6 6 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 CDW51955.1 - 0.0063 16.8 33.3 3.6 8.0 0.1 7.9 2 2 4 6 6 6 2 C2H2 type zinc-finger (2 copies) C1_4 PF07975.12 CDW51955.1 - 0.0096 16.1 28.1 0.14 12.4 0.5 5.5 4 3 0 5 5 5 2 TFIIH C1-like domain GAGA PF09237.11 CDW51955.1 - 0.02 14.7 9.3 0.51 10.2 0.0 4.3 3 1 2 5 5 4 0 GAGA factor DZR PF12773.7 CDW51955.1 - 0.021 14.8 26.2 0.28 11.2 2.1 5.3 2 2 2 4 4 4 0 Double zinc ribbon Zn_ribbon_SprT PF17283.2 CDW51955.1 - 0.03 14.2 18.5 0.47 10.4 1.1 3.9 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zf-LYAR PF08790.11 CDW51955.1 - 0.044 13.7 31.4 0.39 10.7 0.2 7.6 8 0 0 8 8 8 0 LYAR-type C2HC zinc finger FYDLN_acid PF09538.10 CDW51955.1 - 0.055 14.2 9.4 5.6 7.7 0.0 5.1 3 2 3 6 6 4 0 Protein of unknown function (FYDLN_acid) Rad50_zn_hook PF04423.14 CDW51955.1 - 0.11 12.4 4.0 0.13 12.1 0.3 3.0 3 1 0 3 3 3 0 Rad50 zinc hook motif PyrI_C PF02748.15 CDW51955.1 - 0.12 12.3 22.7 1.3 9.0 0.2 7.4 7 1 1 8 8 8 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn-C2H2_12 PF18112.1 CDW51955.1 - 0.13 12.7 0.3 0.13 12.7 0.3 5.2 7 0 0 7 7 4 0 Autophagy receptor zinc finger-C2H2 domain DUF2180 PF09947.9 CDW51955.1 - 0.29 11.1 16.6 0.098 12.6 0.6 4.8 3 2 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2180) zf-U1 PF06220.12 CDW51955.1 - 0.98 9.2 0.1 0.98 9.2 0.1 4.4 5 0 0 5 5 3 0 U1 zinc finger zf-C2H2_9 PF16293.5 CDW51955.1 - 1.6 8.6 5.4 10 6.0 0.2 4.0 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_9 PF14369.6 CDW51955.1 - 3.5 8.0 24.0 5.6 7.3 0.1 6.8 7 1 0 7 7 6 0 zinc-ribbon zf-MYST PF17772.1 CDW51955.1 - 3.8 7.2 30.1 3.1 7.5 1.2 6.4 4 2 3 7 7 6 0 MYST family zinc finger domain zf-FCS PF06467.14 CDW51955.1 - 4.1 7.4 28.7 1.5 8.8 1.9 7.4 8 0 0 8 8 8 0 MYM-type Zinc finger with FCS sequence motif DUF3268 PF11672.8 CDW51955.1 - 4.1 7.7 21.5 2.9 8.3 1.4 4.6 3 2 3 6 6 6 0 zinc-finger-containing domain DUF4187 PF13821.6 CDW51955.1 - 6.4 6.6 19.4 4.3 7.2 0.1 6.7 7 1 1 8 8 8 0 Domain of unknown function (DUF4187) Vps36-NZF-N PF16988.5 CDW51955.1 - 8.9 5.8 14.0 3.8 7.0 0.1 4.6 4 1 1 5 5 5 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Cyclin_N PF00134.23 CDW51956.1 - 4.3e-37 126.7 0.0 7.2e-37 126.0 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDW51956.1 - 3.1e-15 56.3 0.0 4.9e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF1494 PF07379.11 CDW51957.1 - 0.012 15.4 0.8 0.022 14.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1494) DUF5067 PF16729.5 CDW51957.1 - 0.027 14.4 0.1 0.048 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5067) RIFIN PF02009.16 CDW51958.1 - 0.0029 17.6 0.6 0.0035 17.3 0.6 1.2 1 0 0 1 1 1 1 Rifin Rax2 PF12768.7 CDW51958.1 - 0.016 14.7 1.2 0.14 11.6 0.3 2.2 2 0 0 2 2 2 0 Cortical protein marker for cell polarity DUF5067 PF16729.5 CDW51958.1 - 0.13 12.2 0.3 0.24 11.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5067) Laminin_EGF PF00053.24 CDW51958.1 - 0.28 11.4 5.0 0.71 10.1 5.0 1.7 1 0 0 1 1 1 0 Laminin EGF domain PulG PF11773.8 CDW51958.1 - 0.34 10.8 2.5 1.3 8.9 0.1 2.2 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin EGF_2 PF07974.13 CDW51958.1 - 0.45 10.9 5.4 1.1 9.6 5.4 1.7 1 0 0 1 1 1 0 EGF-like domain Alba PF01918.21 CDW51959.1 - 5.9e-11 42.0 1.0 8.8e-11 41.5 1.0 1.3 1 0 0 1 1 1 1 Alba HEM4 PF02602.15 CDW51959.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD Sigma70_r4_2 PF08281.12 CDW51959.1 - 0.025 14.2 0.7 0.93 9.2 0.2 2.7 3 0 0 3 3 3 0 Sigma-70, region 4 DUF4147 PF13660.6 CDW51959.1 - 0.09 12.3 0.1 0.12 11.9 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4147) GTP1_OBG PF01018.22 CDW51960.1 - 4.9e-18 65.2 5.9 1.9e-17 63.3 5.9 1.9 1 1 0 1 1 1 1 GTP1/OBG TTC5_OB PF16669.5 CDW51960.1 - 4.9e-17 61.7 0.0 8.3e-17 60.9 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain MMR_HSR1 PF01926.23 CDW51960.1 - 3.1e-07 30.5 0.0 6.6e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase TPR_2 PF07719.17 CDW51960.1 - 0.0041 17.1 5.4 0.55 10.5 0.9 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDW51960.1 - 0.018 14.8 9.0 0.47 10.4 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Neur_chan_LBD PF02931.23 CDW51961.1 - 9.6e-44 149.4 1.8 1.3e-43 149.0 1.8 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW51961.1 - 6.9e-25 88.5 6.1 2.2e-23 83.6 6.1 2.3 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region OAD_gamma PF04277.13 CDW51961.1 - 0.0049 17.4 0.1 0.036 14.7 0.0 2.2 2 0 0 2 2 2 1 Oxaloacetate decarboxylase, gamma chain HLH PF00010.26 CDW51962.1 - 4.5e-19 68.1 0.5 7.8e-19 67.4 0.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Auts2 PF15336.6 CDW51964.1 - 0.00028 21.1 0.0 0.00028 21.1 0.0 3.5 3 0 0 3 3 3 1 Autism susceptibility gene 2 protein PRIMA1 PF16101.5 CDW51964.1 - 1.5 8.8 4.9 9.1 6.3 4.9 2.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Fer4_7 PF12838.7 CDW51965.1 - 2.8e-12 47.0 13.1 4.1e-12 46.5 13.1 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CDW51965.1 - 5.4e-12 45.0 20.3 2.5e-06 27.1 7.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.6 CDW51965.1 - 2.3e-10 41.2 8.5 1.4e-05 25.9 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 CDW51965.1 - 1.8e-07 31.2 13.5 3e-07 30.5 13.5 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDW51965.1 - 3.2e-07 30.4 26.6 4.3e-05 23.5 16.1 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDW51965.1 - 8.3e-07 29.0 27.2 3.4e-05 23.9 15.7 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDW51965.1 - 4.4e-06 27.0 22.6 0.00045 20.6 13.4 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDW51965.1 - 1.6e-05 24.7 15.5 0.01 15.9 2.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.7 CDW51965.1 - 1.7e-05 24.7 21.0 0.0003 20.7 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDW51965.1 - 6.9e-05 23.1 14.1 0.00027 21.2 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CDW51965.1 - 0.0042 17.6 15.4 0.11 13.0 16.0 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDW51965.1 - 0.0046 17.8 16.5 0.011 16.6 4.2 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.10 CDW51965.1 - 0.029 14.6 7.1 0.2 11.9 0.2 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_13 PF13370.6 CDW51965.1 - 0.06 13.9 17.9 0.57 10.8 4.3 2.4 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 CDW51965.1 - 0.36 11.0 11.8 50 4.1 12.0 2.2 1 1 0 1 1 1 0 4Fe-4S dicluster domain ETF_QO PF05187.13 CDW51965.1 - 0.66 10.1 7.8 0.39 10.9 0.5 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 CDW51965.1 - 4 8.3 14.3 19 6.2 4.3 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain R3H PF01424.22 CDW51966.1 - 2.8e-12 46.4 0.4 8.1e-12 45.0 0.4 1.8 1 0 0 1 1 1 1 R3H domain UCH PF00443.29 CDW51967.1 - 4.2e-25 88.7 5.5 2.4e-24 86.2 5.5 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW51967.1 - 0.00056 19.6 14.4 0.51 9.9 14.4 2.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TetR PF13972.6 CDW51967.1 - 0.055 13.2 0.3 0.096 12.4 0.3 1.3 1 0 0 1 1 1 0 Bacterial transcriptional repressor Cytochrome_C554 PF13435.6 CDW51967.1 - 0.078 13.9 1.0 0.14 13.1 1.0 1.4 1 0 0 1 1 1 0 Cytochrome c554 and c-prime NFACT-R_1 PF05670.13 CDW51968.1 - 2.8e-41 140.5 0.0 4.2e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 NFACT protein RNA binding domain DUF4670 PF15709.5 CDW51968.1 - 0.0038 16.6 13.3 0.0048 16.3 13.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4670) U79_P34 PF03064.16 CDW51968.1 - 0.083 12.2 7.7 0.1 11.9 7.7 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Pkinase PF00069.25 CDW51969.1 - 3.8e-69 233.0 0.0 5.3e-69 232.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW51969.1 - 1.9e-34 119.1 0.0 2.7e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW51969.1 - 4.1e-06 26.3 0.0 1.3e-05 24.7 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW51969.1 - 0.00032 19.8 4.0 0.00065 18.7 0.5 2.4 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 CDW51969.1 - 0.01 15.2 0.2 0.019 14.3 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW51969.1 - 0.15 12.0 0.2 1.5 8.7 0.1 2.0 1 1 0 2 2 2 0 Phosphotransferase enzyme family Adaptin_N PF01602.20 CDW51970.1 - 6.3e-83 279.1 1.3 7.5e-83 278.8 1.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CDW51970.1 - 3.1e-18 66.4 0.7 1.1e-17 64.5 0.2 2.0 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDW51970.1 - 3.5e-08 33.7 0.6 4.5e-05 23.8 0.2 3.2 1 1 2 3 3 3 3 HEAT repeats HEAT PF02985.22 CDW51970.1 - 2.1e-07 30.6 0.1 0.023 14.9 0.0 4.1 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 CDW51970.1 - 0.0084 16.6 0.3 0.11 13.0 0.0 3.0 3 1 1 4 4 4 1 HEAT-like repeat Lact-deh-memb PF09330.11 CDW51970.1 - 0.051 12.9 0.0 0.073 12.4 0.0 1.2 1 0 0 1 1 1 0 D-lactate dehydrogenase, membrane binding T2SSF PF00482.23 CDW51970.1 - 0.074 13.0 0.4 0.15 12.0 0.4 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF5578 PF17741.1 CDW51970.1 - 0.11 11.9 0.6 0.25 10.7 0.2 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5578) ERAP1_C PF11838.8 CDW51970.1 - 0.11 12.0 0.0 0.49 9.9 0.0 1.8 1 1 0 2 2 2 0 ERAP1-like C-terminal domain MASE1 PF05231.14 CDW51971.1 - 0.0007 18.8 0.3 0.0011 18.2 0.3 1.3 1 0 0 1 1 1 1 MASE1 CKS PF01111.19 CDW51972.1 - 5.4e-34 116.3 2.3 6.7e-34 116.0 2.3 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Homeodomain PF00046.29 CDW51973.1 - 1.8e-20 72.5 9.4 2.9e-20 71.9 9.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW51973.1 - 0.0059 16.5 0.3 0.012 15.5 0.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain K_channel_TID PF07941.11 CDW51973.1 - 0.49 10.9 7.5 0.082 13.4 2.5 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain SLY PF12485.8 CDW51974.1 - 0.0025 18.6 1.3 0.62 10.8 1.5 2.1 2 0 0 2 2 2 2 Lymphocyte signaling adaptor protein LANC_like PF05147.13 CDW51975.1 - 3.6e-77 259.3 3.9 4.5e-77 259.0 3.9 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_88 PF07470.13 CDW51975.1 - 0.0023 17.1 0.2 0.023 13.8 0.1 2.4 2 1 1 3 3 3 1 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 CDW51975.1 - 0.015 14.8 0.5 5.7 6.4 0.1 2.7 3 0 0 3 3 3 0 D-glucuronyl C5-epimerase C-terminus TPR_19 PF14559.6 CDW51975.1 - 0.016 15.7 0.1 0.082 13.4 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_127 PF07944.12 CDW51975.1 - 0.024 13.2 1.9 0.29 9.6 0.3 2.5 2 1 1 3 3 3 0 Beta-L-arabinofuranosidase, GH127 GlcNAc_2-epim PF07221.11 CDW51975.1 - 0.032 13.5 0.2 6.1 6.0 0.0 2.6 2 1 0 2 2 2 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) DUF4810 PF16068.5 CDW51975.1 - 0.13 12.8 0.1 0.36 11.4 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4810) SPOB_a PF14689.6 CDW51975.1 - 0.13 12.0 0.3 2.1 8.1 0.0 3.0 3 0 0 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_8 PF13181.6 CDW51975.1 - 0.96 9.8 5.6 3.4 8.1 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDW51975.1 - 3.1 8.1 5.3 3.2 8.1 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Homeodomain PF00046.29 CDW51977.1 - 2.1e-20 72.3 8.1 3.5e-20 71.6 8.1 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW51977.1 - 0.0038 17.1 0.5 0.009 15.9 0.5 1.7 1 0 0 1 1 1 1 Homeobox KN domain SusE PF14292.6 CDW51977.1 - 0.065 13.5 1.8 0.1 12.8 1.8 1.2 1 0 0 1 1 1 0 SusE outer membrane protein Pox_E8 PF03394.13 CDW51977.1 - 0.13 11.8 0.1 0.17 11.4 0.1 1.1 1 0 0 1 1 1 0 Poxvirus E8 protein Homeodomain PF00046.29 CDW51984.1 - 4.2e-23 80.9 10.5 5.4e-23 80.6 10.5 1.1 1 0 0 1 1 1 1 Homeodomain Terminase_5 PF06056.12 CDW51984.1 - 0.0084 16.0 0.3 0.013 15.4 0.3 1.3 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) Homeobox_KN PF05920.11 CDW51984.1 - 0.021 14.7 0.6 0.037 13.9 0.6 1.5 1 0 0 1 1 1 0 Homeobox KN domain HTH_23 PF13384.6 CDW51984.1 - 0.041 13.7 0.3 0.073 12.9 0.3 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Ank_2 PF12796.7 CDW51985.1 - 8e-25 87.2 0.8 3.1e-16 59.7 0.1 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW51985.1 - 1.2e-20 73.5 0.3 8.2e-16 58.2 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CDW51985.1 - 5.1e-16 58.3 3.0 2.7e-07 30.7 0.1 3.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 CDW51985.1 - 1.3e-15 55.9 0.9 2.7e-06 27.3 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 CDW51985.1 - 3.5e-13 49.5 0.4 2.2e-09 37.4 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_1 PF00018.28 CDW51985.1 - 4.6e-10 38.9 0.3 9.8e-10 37.9 0.3 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CDW51985.1 - 1.3e-08 34.4 0.1 2.5e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CDW51985.1 - 2e-07 30.8 0.1 4.1e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain GIT_CC PF16559.5 CDW51985.1 - 0.16 11.9 0.8 0.41 10.6 0.8 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor LSM PF01423.22 CDW51986.1 - 5.4e-22 77.3 0.1 5.8e-22 77.1 0.1 1.0 1 0 0 1 1 1 1 LSM domain Aminotran_5 PF00266.19 CDW51987.1 - 4.7e-12 45.6 0.0 7.8e-12 44.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Homeodomain PF00046.29 CDW51988.1 - 1.4e-22 79.3 8.1 1.8e-22 79.0 8.1 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW51988.1 - 0.0023 17.8 0.9 0.0048 16.8 0.9 1.5 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.6 CDW51988.1 - 0.0051 16.6 0.6 0.015 15.1 0.4 1.9 2 0 0 2 2 2 1 Homeodomain-like domain GerE PF00196.19 CDW51988.1 - 0.048 13.2 0.1 0.075 12.6 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDW51988.1 - 0.097 12.4 0.1 0.55 9.9 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 FSA_C PF10479.9 CDW51989.1 - 0.33 9.0 2.6 0.46 8.6 2.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Homeodomain PF00046.29 CDW51991.1 - 2.6e-45 152.0 19.2 9.1e-23 79.9 4.7 2.2 2 0 0 2 2 2 2 Homeodomain Homeobox_KN PF05920.11 CDW51991.1 - 4.2e-05 23.4 8.5 0.012 15.5 0.3 3.1 3 0 0 3 3 3 2 Homeobox KN domain Terminase_5 PF06056.12 CDW51991.1 - 0.017 15.0 0.3 0.92 9.4 0.0 2.3 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Ubiquitin_5 PF18037.1 CDW51991.1 - 0.026 14.9 0.8 0.7 10.3 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-like domain HTH_23 PF13384.6 CDW51991.1 - 0.048 13.5 0.7 0.91 9.4 0.1 2.3 2 0 0 2 2 2 0 Homeodomain-like domain Homez PF11569.8 CDW51991.1 - 0.16 11.4 0.6 19 4.8 0.1 2.4 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez MerR_1 PF13411.6 CDW51991.1 - 0.93 9.6 4.3 21 5.3 0.1 3.7 4 1 0 4 4 4 0 MerR HTH family regulatory protein Homeodomain PF00046.29 CDW51992.1 - 1.3e-18 66.5 3.6 2.6e-18 65.6 3.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW51992.1 - 0.0068 16.3 0.5 0.014 15.3 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Myotub-related PF06602.14 CDW51993.1 - 1.9e-134 448.1 0.5 1.9e-134 448.1 0.5 1.9 2 1 0 2 2 2 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 CDW51993.1 - 0.00036 20.2 0.0 0.00072 19.2 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase GRAM PF02893.20 CDW51993.1 - 0.00056 19.8 0.4 0.0025 17.7 0.2 2.2 1 1 0 1 1 1 1 GRAM domain DSPc PF00782.20 CDW51993.1 - 0.012 15.4 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CDW51993.1 - 0.017 15.1 0.1 0.039 13.9 0.0 1.5 2 0 0 2 2 2 0 Tyrosine phosphatase family 3-PAP PF12578.8 CDW51993.1 - 0.076 12.8 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 Myotubularin-associated protein POB3_N PF17292.2 CDW51994.1 - 1.5e-29 102.2 0.2 8.6e-27 93.4 0.1 2.7 2 0 0 2 2 2 2 POB3-like N-terminal PH domain Rtt106 PF08512.12 CDW51994.1 - 1e-24 86.8 0.1 1.1e-22 80.2 0.1 2.7 3 0 0 3 3 3 1 Histone chaperone Rttp106-like SSrecog PF03531.14 CDW51994.1 - 4.5e-21 74.5 0.0 1.8e-20 72.6 0.0 2.1 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) HMG_box PF00505.19 CDW51994.1 - 5e-16 58.9 5.8 5e-16 58.9 5.8 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW51994.1 - 4.6e-10 40.0 5.0 4.6e-10 40.0 5.0 2.1 2 0 0 2 2 2 1 HMG-box domain bPH_3 PF14470.6 CDW51994.1 - 0.13 12.7 0.1 1.7 9.1 0.1 2.3 2 0 0 2 2 2 0 Bacterial PH domain CDC45 PF02724.14 CDW51994.1 - 4 5.6 20.6 6.5 4.9 20.6 1.3 1 0 0 1 1 1 0 CDC45-like protein RIIa PF02197.17 CDW51995.1 - 0.00098 18.7 0.1 0.0017 18.0 0.1 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Ribosomal_S7e PF01251.18 CDW51996.1 - 6.9e-71 237.8 1.3 7.6e-71 237.7 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e CAP PF00188.26 CDW51997.1 - 1.6e-12 48.3 13.8 1.1e-06 29.4 4.4 2.4 2 0 0 2 2 2 2 Cysteine-rich secretory protein family zf-HC5HC2H_2 PF13832.6 CDW51997.1 - 0.048 13.8 10.5 0.081 13.1 1.7 2.9 2 1 0 2 2 2 0 PHD-zinc-finger like domain CRAL_TRIO PF00650.20 CDW51999.1 - 2e-37 128.4 0.0 3.5e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain PRELI PF04707.14 CDW51999.1 - 1.1e-23 83.8 0.1 2.1e-22 79.6 0.1 2.3 1 1 0 1 1 1 1 PRELI-like family CRAL_TRIO_N PF03765.15 CDW51999.1 - 0.00071 19.7 0.0 0.0017 18.5 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Ets PF00178.22 CDW52000.1 - 6.4e-36 122.7 2.0 1.1e-35 122.0 1.0 1.8 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.16 CDW52000.1 - 1.6e-27 95.3 0.0 3.1e-27 94.3 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain LIM PF00412.22 CDW52001.1 - 4.8e-20 71.5 50.5 2.6e-06 27.5 1.9 5.0 4 1 0 4 4 4 4 LIM domain VHP PF02209.19 CDW52001.1 - 4.8e-12 45.7 0.6 1e-11 44.7 0.6 1.5 1 0 0 1 1 1 1 Villin headpiece domain CENP-W PF15510.6 CDW52001.1 - 0.032 14.4 0.7 0.1 12.8 0.7 1.8 1 0 0 1 1 1 0 CENP-W protein DUF2079 PF09852.9 CDW52002.1 - 0.016 14.1 1.7 0.019 13.9 1.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) DUF3159 PF11361.8 CDW52002.1 - 0.046 13.5 1.3 0.063 13.0 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3159) Cation_efflux PF01545.21 CDW52002.1 - 0.46 10.2 5.5 0.64 9.7 5.5 1.2 1 0 0 1 1 1 0 Cation efflux family WD40 PF00400.32 CDW52003.1 - 3.3e-16 59.4 15.0 0.00046 20.9 0.2 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52003.1 - 0.00033 20.9 0.0 0.26 11.6 0.0 3.1 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain EssA PF10661.9 CDW52003.1 - 0.0068 16.2 3.9 0.013 15.4 3.9 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein EssA BSD PF03909.17 CDW52004.1 - 1.3e-19 69.9 2.8 9.9e-15 54.3 0.5 2.6 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 CDW52004.1 - 4.4e-19 68.6 0.0 1.3e-18 67.0 0.0 1.9 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain DUF759 PF05537.11 CDW52004.1 - 0.059 12.2 0.1 0.87 8.4 0.0 2.2 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF759) EDR1 PF14381.6 CDW52006.1 - 0.045 13.5 0.6 0.16 11.6 0.6 1.9 1 1 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 ING PF12998.7 CDW52006.1 - 0.1 13.2 1.8 0.91 10.1 0.0 3.0 3 1 1 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding zf-primase PF09329.11 CDW52006.1 - 0.99 9.3 9.8 4.3 7.2 0.1 3.6 3 0 0 3 3 3 0 Primase zinc finger DUF4588 PF15251.6 CDW52007.1 - 1.1e-08 35.2 0.0 2.2e-08 34.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) Neur_chan_LBD PF02931.23 CDW52008.1 - 5.9e-46 156.6 2.3 8.8e-46 156.1 2.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW52008.1 - 1.1e-23 84.5 5.8 3.1e-20 73.3 0.9 2.2 1 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region CTU2 PF10288.9 CDW52009.1 - 5.6e-06 26.6 0.5 5.6e-06 26.6 0.5 3.3 3 1 1 4 4 4 1 Cytoplasmic tRNA 2-thiolation protein 2 zf-C2HCIx2C PF10782.9 CDW52009.1 - 1.9 8.5 7.4 4.7 7.2 0.2 3.2 4 0 0 4 4 4 0 Zinc-finger Cupin_8 PF13621.6 CDW52010.1 - 2.2e-59 201.2 0.5 3.1e-59 200.7 0.5 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CDW52010.1 - 9.1e-09 35.2 0.0 0.0038 16.7 0.0 2.8 3 0 0 3 3 3 2 Cupin superfamily protein Nup84_Nup100 PF04121.13 CDW52011.1 - 7.4e-106 355.0 7.5 1e-105 354.5 7.5 1.2 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 DUF3990 PF13151.6 CDW52011.1 - 0.055 13.1 0.1 0.13 11.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) WD40 PF00400.32 CDW52012.1 - 2.8e-06 27.9 0.4 0.13 13.2 0.0 4.3 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52012.1 - 9.8e-05 22.6 0.0 0.099 12.9 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW52012.1 - 0.0066 15.4 0.6 0.25 10.2 0.1 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-CCCH PF00642.24 CDW52013.1 - 0.0003 20.6 2.3 0.00081 19.2 2.3 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Fer4_4 PF12800.7 CDW52013.1 - 2.2 9.0 5.7 22 5.9 5.7 2.8 1 1 0 1 1 1 0 4Fe-4S binding domain zf_CCCH_5 PF18384.1 CDW52014.1 - 1.6e-18 66.5 9.9 1.6e-18 66.5 9.9 3.0 2 0 0 2 2 2 1 Unkempt Zinc finger domain 1 (Znf1) zf_CCCH_4 PF18345.1 CDW52014.1 - 0.17 12.0 0.0 0.17 12.0 0.0 4.8 4 1 0 4 4 4 0 Zinc finger domain zf-CCCH PF00642.24 CDW52014.1 - 0.44 10.5 0.0 0.44 10.5 0.0 5.8 6 1 0 6 6 6 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3H1 PF10650.9 CDW52014.1 - 0.54 10.0 5.3 0.19 11.5 0.7 2.7 2 0 0 2 2 2 0 Putative zinc-finger domain RNase_H PF00075.24 CDW52016.1 - 1.7e-41 141.7 0.4 2.8e-41 141.1 0.4 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 CDW52016.1 - 3.5e-19 68.8 0.4 7.6e-19 67.7 0.4 1.6 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.6 CDW52016.1 - 1.4e-05 24.9 0.3 4.6e-05 23.2 0.3 2.0 1 1 0 1 1 1 1 Reverse transcriptase-like DUF2786 PF10979.8 CDW52016.1 - 0.019 14.9 0.9 0.043 13.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) TMF_TATA_bd PF12325.8 CDW52017.1 - 1.5e-14 54.2 9.6 1.5e-14 54.2 9.6 6.7 2 1 5 7 7 7 2 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 CDW52017.1 - 4.2e-11 42.7 23.8 4.2e-11 42.7 23.8 8.5 3 1 5 10 10 10 2 TATA element modulatory factor 1 DNA binding Rav1p_C PF12234.8 CDW52018.1 - 1.3e-73 248.6 13.6 6.3e-64 216.5 6.2 3.9 3 1 1 4 4 4 3 RAVE protein 1 C terminal WD40 PF00400.32 CDW52018.1 - 1.2e-10 41.8 23.1 0.014 16.3 2.5 9.5 11 0 0 11 11 11 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52018.1 - 9.1e-06 25.9 0.1 3.4 8.0 0.0 5.8 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Na_trans_assoc PF06512.13 CDW52018.1 - 2.5 8.3 5.9 23 5.2 1.6 3.4 3 0 0 3 3 3 0 Sodium ion transport-associated Phg_2220_C PF09524.10 CDW52019.1 - 0.044 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Conserved phage C-terminus (Phg_2220_C) Rab3-GTPase_cat PF13890.6 CDW52019.1 - 0.085 12.5 0.2 2.2 7.9 0.1 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein catalytic subunit NPHI_C PF08469.10 CDW52019.1 - 0.2 11.6 0.3 1.2 9.1 0.1 2.2 2 1 0 2 2 2 0 Nucleoside triphosphatase I C-terminal FlbD PF06289.11 CDW52020.1 - 0.12 12.0 0.0 5.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Flagellar and Swarming motility proteins LRR19-TM PF15176.6 CDW52020.1 - 0.15 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain BTB PF00651.31 CDW52021.1 - 1.1e-15 57.8 0.8 1.9e-15 57.0 0.8 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 CDW52022.1 - 2.8e-15 56.5 0.6 6.3e-15 55.4 0.6 1.6 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 CDW52023.1 - 7e-21 74.5 7.4 3.3e-11 43.4 0.9 2.6 2 0 0 2 2 2 2 BTB/POZ domain Phospholamban PF04272.14 CDW52023.1 - 0.00072 19.0 0.4 3.1 7.3 0.0 3.4 3 0 0 3 3 3 2 Phospholamban DUF4535 PF15054.6 CDW52023.1 - 0.16 11.7 0.1 4.9 7.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4535) BTB PF00651.31 CDW52024.1 - 5.3e-05 23.4 0.1 9.3e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain Focal_AT PF03623.13 CDW52024.1 - 0.039 13.9 0.2 0.059 13.4 0.2 1.3 1 1 0 1 1 1 0 Focal adhesion targeting region EntA_Immun PF08951.10 CDW52024.1 - 0.086 13.2 0.0 0.18 12.2 0.0 1.6 1 1 0 1 1 1 0 Enterocin A Immunity CH PF00307.31 CDW52026.1 - 2e-82 272.5 1.6 1e-20 74.0 0.0 4.5 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 CDW52026.1 - 2.1e-08 33.9 0.1 0.007 16.2 0.0 3.9 4 0 0 4 4 4 2 CAMSAP CH domain CH_2 PF06294.11 CDW52026.1 - 2.6e-05 24.2 0.2 5.3 7.2 0.1 4.6 5 0 0 5 5 5 3 CH-like domain in sperm protein GMC_oxred_N PF00732.19 CDW52027.1 - 3.2e-30 105.5 0.0 4.1e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CDW52027.1 - 4.3e-19 69.5 0.0 8.5e-19 68.5 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CDW52027.1 - 2.5e-05 24.0 0.1 0.0025 17.5 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDW52027.1 - 0.0011 19.1 0.2 0.005 17.0 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain ThiF PF00899.21 CDW52027.1 - 0.062 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 ThiF family FAD_binding_2 PF00890.24 CDW52027.1 - 0.13 11.3 0.1 2.8 6.9 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_2 PF07992.14 CDW52027.1 - 0.16 11.2 0.0 0.58 9.3 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDW52027.1 - 0.18 11.8 0.1 0.82 9.6 0.0 2.2 2 1 0 2 2 2 0 FAD-NAD(P)-binding Patched PF02460.18 CDW52028.1 - 7.9e-238 791.6 12.9 9.4e-238 791.4 12.9 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW52028.1 - 6.8e-38 129.9 11.0 6.8e-38 129.9 11.0 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Myelin_MBP PF01669.17 CDW52028.1 - 0.15 12.7 0.0 0.29 11.7 0.0 1.4 1 0 0 1 1 1 0 Myelin basic protein 7TM_GPCR_Srsx PF10320.9 CDW52029.1 - 7.6e-16 58.3 22.4 1e-15 57.9 22.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW52029.1 - 0.032 13.8 24.8 0.054 13.1 20.9 2.7 2 1 1 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 CDW52029.1 - 0.095 12.0 21.3 0.26 10.6 21.4 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Spo7 PF03907.13 CDW52029.1 - 1.8 8.0 5.0 0.96 8.9 0.2 2.4 2 1 1 3 3 3 0 Spo7-like protein Glyco_hydro_30 PF02055.16 CDW52030.1 - 1.4e-144 481.4 0.8 1.7e-144 481.1 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 CDW52030.1 - 2.4e-12 46.9 0.0 4.8e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 CDW52030.1 - 0.00022 20.6 0.1 0.00085 18.6 0.1 1.9 1 1 1 2 2 2 1 Glycosyl hydrolase family 59 YbjQ_1 PF01906.17 CDW52030.1 - 0.049 14.3 0.0 0.093 13.4 0.0 1.4 1 0 0 1 1 1 0 Putative heavy-metal-binding WD40 PF00400.32 CDW52031.1 - 0.0002 22.1 4.8 0.13 13.2 0.0 4.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Melibiase_2 PF16499.5 CDW52032.1 - 1e-114 382.5 1.9 1.3e-114 382.2 1.9 1.1 1 0 0 1 1 1 1 Alpha galactosidase A TMA7 PF09072.10 CDW52032.1 - 2.6e-19 69.8 11.5 4.6e-19 69.0 11.5 1.3 1 0 0 1 1 1 1 Translation machinery associated TMA7 Melibiase PF02065.18 CDW52032.1 - 7.5e-05 21.8 0.1 0.00012 21.1 0.1 1.2 1 0 0 1 1 1 1 Melibiase Melibiase_C PF17801.1 CDW52032.1 - 0.0037 17.3 0.0 0.014 15.5 0.0 2.0 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2_C PF17450.2 CDW52032.1 - 0.014 15.6 0.0 0.031 14.5 0.0 1.6 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain BBS2_Mid PF14783.6 CDW52033.1 - 9.6e-42 141.4 0.1 2.4e-41 140.2 0.0 1.7 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region BBS2_N PF14781.6 CDW52033.1 - 4.4e-18 65.1 0.0 1.5e-17 63.4 0.0 1.8 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal Itfg2 PF15907.5 CDW52033.1 - 8.4e-09 34.9 0.1 3.3e-05 23.1 0.1 2.5 1 1 0 2 2 2 2 Integrin-alpha FG-GAP repeat-containing protein 2 VCBS PF13517.6 CDW52033.1 - 2.1e-07 31.4 0.6 0.00043 20.8 0.2 3.1 1 1 1 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDW52033.1 - 0.00011 22.2 0.4 0.13 12.4 0.2 2.7 2 0 0 2 2 2 2 FG-GAP repeat BBS1 PF14779.6 CDW52033.1 - 0.00087 18.8 0.1 1.1 8.7 0.0 2.7 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 1 Mtr2 PF10429.9 CDW52033.1 - 0.11 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 WD40 PF00400.32 CDW52033.1 - 0.33 11.9 1.6 0.81 10.7 0.4 2.3 2 0 0 2 2 2 0 WD domain, G-beta repeat zf-RING_4 PF14570.6 CDW52034.1 - 1.2e-18 66.6 11.9 1.2e-18 66.6 11.9 2.5 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 CDW52034.1 - 4.5e-05 23.2 0.0 8.9e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDW52034.1 - 0.00062 19.7 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-UDP PF14569.6 CDW52034.1 - 0.0011 19.1 4.1 0.0027 17.8 4.1 1.6 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-RING_2 PF13639.6 CDW52034.1 - 0.0097 16.2 10.5 0.0097 16.2 10.5 2.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW52034.1 - 0.011 15.6 10.3 0.011 15.6 10.3 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Torus PF16131.5 CDW52034.1 - 0.032 14.9 0.2 0.077 13.7 0.2 1.6 1 0 0 1 1 1 0 Torus domain DUF2152 PF10222.9 CDW52035.1 - 1.1e-112 377.4 5.6 2e-87 294.0 6.8 3.6 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2152) Ras PF00071.22 CDW52036.1 - 2.1e-34 118.5 0.0 2.4e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52036.1 - 1.1e-26 93.3 0.0 1.5e-26 92.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52036.1 - 2.1e-10 40.3 0.0 2.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW52036.1 - 1.4e-05 24.7 0.2 0.0059 16.2 0.0 2.2 1 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDW52036.1 - 0.00035 20.0 0.0 0.00053 19.4 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 CDW52036.1 - 0.00075 19.1 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ATP_bind_1 PF03029.17 CDW52036.1 - 0.0012 18.7 0.0 0.15 11.8 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 CDW52036.1 - 0.0063 16.3 0.0 0.18 11.6 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 CDW52036.1 - 0.0076 16.5 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CDW52036.1 - 0.013 15.0 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein MCM PF00493.23 CDW52036.1 - 0.023 13.8 0.0 0.094 11.8 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain AAA_16 PF13191.6 CDW52036.1 - 0.046 14.1 0.0 0.063 13.7 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CDW52036.1 - 0.048 13.7 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.19 CDW52036.1 - 0.053 13.1 0.0 2.9 7.4 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CDW52036.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDW52036.1 - 0.13 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 CDW52036.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 CDW52037.1 - 6.5e-38 130.2 0.0 1.3e-37 129.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW52037.1 - 7.4e-25 87.5 1.2 5.8e-24 84.6 0.3 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW52037.1 - 1e-08 35.4 0.0 2e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CDW52037.1 - 3.9e-05 23.1 0.0 8.6e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit tRNA-synt_1 PF00133.22 CDW52038.1 - 8.7e-161 536.2 0.0 1.2e-159 532.4 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Glyco_transf_22 PF03901.17 CDW52038.1 - 2.1e-43 149.1 31.5 3.1e-43 148.6 31.5 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Anticodon_1 PF08264.13 CDW52038.1 - 1.2e-29 103.2 0.2 2.6e-29 102.1 0.2 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA RNase_PH PF01138.21 CDW52038.1 - 5.4e-17 62.5 0.9 1.5e-16 61.1 0.9 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 tRNA-synt_1g PF09334.11 CDW52038.1 - 1.7e-15 56.7 0.0 5.9e-06 25.3 0.0 3.6 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CDW52038.1 - 0.00065 19.3 0.0 0.0064 16.0 0.0 2.2 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1d PF00750.19 CDW52038.1 - 0.018 14.0 1.1 0.26 10.2 0.0 2.6 3 0 0 3 3 3 0 tRNA synthetases class I (R) Pdase_C33_assoc PF14756.6 CDW52038.1 - 0.047 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase_C33-associated domain Ly-6_related PF06579.12 CDW52040.1 - 2.1e-32 112.0 0.9 2.6e-32 111.7 0.9 1.1 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein QVR PF17064.5 CDW52040.1 - 0.0071 16.6 7.1 4.7 7.5 3.2 3.1 2 1 0 2 2 2 2 Sleepless protein DUF1011 PF06237.12 CDW52040.1 - 0.044 14.1 0.7 0.084 13.2 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1011) NMD3 PF04981.13 CDW52040.1 - 0.081 12.4 0.3 0.1 12.0 0.3 1.1 1 0 0 1 1 1 0 NMD3 family DUF4461 PF14688.6 CDW52041.1 - 7.6e-23 81.8 1.4 2.2e-17 63.8 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4461) DUF4460 PF14687.6 CDW52041.1 - 2.9e-19 69.2 0.0 5.5e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4460) CytochromB561_N PF09786.9 CDW52041.1 - 0.13 11.2 0.1 0.18 10.7 0.1 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal DDE_5 PF13546.6 CDW52041.1 - 0.15 11.4 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease ANAPC4_WD40 PF12894.7 CDW52042.1 - 0.0002 21.6 0.0 0.038 14.3 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDW52042.1 - 0.0067 17.2 1.3 0.039 14.8 0.0 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Frtz PF11768.8 CDW52042.1 - 0.11 10.7 0.0 2.5 6.3 0.0 2.1 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz SH2 PF00017.24 CDW52043.1 - 2.6e-13 49.9 0.9 0.0013 18.8 1.6 4.3 4 0 0 4 4 4 4 SH2 domain VPS11_C PF12451.8 CDW52043.1 - 0.11 12.7 0.3 0.25 11.6 0.3 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal Cornichon PF03311.14 CDW52044.1 - 9e-45 151.9 9.9 1.3e-44 151.4 9.9 1.2 1 0 0 1 1 1 1 Cornichon protein DnaJ PF00226.31 CDW52044.1 - 7.1e-19 67.7 0.2 2.5e-18 65.9 0.2 2.0 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 CDW52044.1 - 8.3e-05 22.3 0.1 0.00033 20.4 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Seryl_tRNA_N PF02403.22 CDW52044.1 - 0.071 13.3 14.3 0.16 12.2 14.3 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3365 PF11845.8 CDW52044.1 - 0.17 12.2 1.1 0.65 10.3 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3365) MARVEL PF01284.23 CDW52044.1 - 0.27 11.2 4.8 5.1 7.1 0.0 2.4 2 0 0 2 2 2 0 Membrane-associating domain ELM2 PF01448.24 CDW52044.1 - 1.8 9.4 4.1 8.8 7.2 0.1 2.7 2 1 0 2 2 2 0 ELM2 domain PsbT PF01405.17 CDW52044.1 - 5.8 6.8 9.8 18 5.2 9.8 1.9 1 0 0 1 1 1 0 Photosystem II reaction centre T protein FapA PF03961.13 CDW52044.1 - 7.9 5.0 8.2 11 4.5 7.6 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A DHHC PF01529.20 CDW52044.1 - 8.7 6.5 10.1 25 5.0 6.3 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Med10 PF09748.9 CDW52045.1 - 9.5e-35 119.2 0.9 1.4e-34 118.6 0.9 1.3 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex UPF0203 PF05254.12 CDW52045.1 - 7.8e-22 77.3 2.1 7.8e-22 77.3 2.1 2.1 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 CDW52045.1 - 0.00094 19.3 2.1 0.7 10.1 0.1 2.9 3 0 0 3 3 3 2 Ubiquinol-cytochrome C reductase hinge protein Helo_like_N PF17111.5 CDW52045.1 - 0.012 15.0 1.2 0.49 9.7 0.0 2.5 2 1 1 3 3 3 0 Fungal N-terminal domain of STAND proteins Jag_N PF14804.6 CDW52045.1 - 0.063 13.6 0.1 5.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Jag N-terminus ZapB PF06005.12 CDW52045.1 - 0.084 13.3 2.3 0.36 11.3 0.4 2.3 2 0 0 2 2 2 0 Cell division protein ZapB Cmc1 PF08583.10 CDW52045.1 - 0.12 12.4 1.8 3 7.9 0.2 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 CDW52045.1 - 0.35 10.6 2.3 0.85 9.4 0.5 2.2 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF2408 PF10303.9 CDW52045.1 - 0.48 11.0 3.3 0.32 11.5 1.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) COX17 PF05051.13 CDW52045.1 - 0.69 10.3 6.5 1.2 9.5 1.6 3.2 3 1 1 4 4 4 0 Cytochrome C oxidase copper chaperone (COX17) Pre-PUA PF17832.1 CDW52046.1 - 1.3e-25 89.9 0.2 1.9e-25 89.4 0.2 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CDW52046.1 - 3.4e-18 65.4 0.0 4.9e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 PUA domain Spectrin PF00435.21 CDW52048.1 - 0 1301.0 280.5 5.8e-23 81.4 0.7 33.4 30 3 1 31 31 31 31 Spectrin repeat CH PF00307.31 CDW52048.1 - 1.5e-47 160.3 3.4 1.4e-23 83.1 0.0 5.3 5 0 0 5 5 5 2 Calponin homology (CH) domain PH_9 PF15410.6 CDW52048.1 - 1.2e-16 61.2 0.0 5e-16 59.1 0.0 2.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CDW52048.1 - 2.3e-11 44.1 0.2 1.8e-10 41.3 0.0 2.7 2 0 0 2 2 2 1 PH domain CAMSAP_CH PF11971.8 CDW52048.1 - 7e-07 29.0 0.0 0.00041 20.1 0.0 2.9 2 0 0 2 2 2 2 CAMSAP CH domain NT5C PF06941.12 CDW52048.1 - 0.017 15.0 7.0 1.7 8.5 0.2 5.4 5 0 0 5 5 5 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) LAMTOR PF15454.6 CDW52048.1 - 0.4 11.3 6.7 6 7.6 0.1 4.1 3 0 0 3 3 3 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator LZ3wCH PF18517.1 CDW52048.1 - 1.8 8.7 10.6 0.67 10.1 0.2 5.3 5 0 0 5 5 5 0 Leucine zipper with capping helix domain Spt5-NGN PF03439.13 CDW52049.1 - 8.3e-23 80.1 0.1 1.7e-22 79.1 0.1 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 CDW52049.1 - 1.9e-19 68.9 18.9 7.6e-07 28.9 0.2 6.1 6 0 0 6 6 6 5 KOW motif CTD PF12815.7 CDW52049.1 - 1.7e-10 41.3 10.7 1.7e-10 41.3 10.7 2.4 2 1 0 2 2 2 1 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 CDW52049.1 - 6.2e-09 36.7 9.2 6.2e-09 36.7 9.2 2.7 3 0 0 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal LSM14 PF12701.7 CDW52049.1 - 0.08 13.1 0.2 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 Scd6-like Sm domain FERM_M PF00373.18 CDW52052.1 - 1.2e-10 41.8 0.0 2.7e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 CDW52052.1 - 0.0032 17.8 0.0 0.0071 16.7 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain ACBP PF00887.19 CDW52052.1 - 0.031 14.5 0.0 0.067 13.4 0.0 1.6 1 0 0 1 1 1 0 Acyl CoA binding protein DRMBL PF07522.14 CDW52053.1 - 1e-09 38.6 0.2 2.1e-09 37.5 0.2 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 CDW52053.1 - 0.037 13.5 0.0 0.096 12.2 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDW52053.1 - 0.51 10.3 2.1 1.7 8.6 0.3 2.1 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Hamartin PF04388.12 CDW52055.1 - 3.7e-60 204.5 3.0 4.6e-53 181.0 0.0 3.2 3 0 0 3 3 3 2 Hamartin protein PA28_beta PF02252.18 CDW52056.1 - 2.5e-50 169.9 0.6 3.6e-50 169.4 0.6 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 CDW52056.1 - 1.7e-10 40.8 0.1 6.7e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 Proteasome activator pa28 alpha subunit UPF0180 PF03698.13 CDW52056.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) DCP1 PF06058.13 CDW52057.1 - 5.9e-30 103.6 0.1 9e-30 103.0 0.1 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family OTU PF02338.19 CDW52058.1 - 0.0013 19.2 1.1 0.0021 18.6 0.1 1.7 2 0 0 2 2 2 1 OTU-like cysteine protease DCP2 PF05026.13 CDW52059.1 - 5.6e-25 87.5 0.2 2.1e-24 85.6 0.0 2.2 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 CDW52059.1 - 1e-15 58.0 0.0 2.8e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain Ras PF00071.22 CDW52060.1 - 6.1e-48 162.5 0.0 9.6e-32 109.8 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 CDW52060.1 - 4.5e-15 55.9 0.0 3.7e-13 49.7 0.0 2.5 1 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52060.1 - 0.00053 19.5 0.0 0.45 9.9 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW52060.1 - 0.00079 19.0 0.0 0.0069 15.9 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW52060.1 - 0.0068 16.3 0.0 0.29 11.0 0.0 2.4 3 0 0 3 3 3 1 RsgA GTPase TFIID-18kDa PF02269.16 CDW52062.1 - 2.1e-33 114.2 0.4 2.5e-33 114.0 0.4 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit SEO_C PF14577.6 CDW52062.1 - 0.069 12.6 0.1 0.09 12.2 0.1 1.2 1 0 0 1 1 1 0 Sieve element occlusion C-terminus Vinculin PF01044.19 CDW52063.1 - 0 1284.6 20.1 0 1281.3 20.1 1.9 1 1 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 CDW52063.1 - 5.3e-05 23.5 20.0 0.05 13.8 4.2 5.9 4 2 2 6 6 6 3 I/LWEQ domain F_actin_bind PF08919.10 CDW52063.1 - 0.036 14.2 4.2 1.2 9.3 0.0 4.7 5 1 0 5 5 5 0 F-actin binding HAUS2 PF15003.6 CDW52063.1 - 0.093 12.5 2.4 1.3 8.7 0.0 3.0 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 2 NolV PF06635.12 CDW52063.1 - 0.1 11.9 1.5 0.36 10.2 0.0 2.4 2 0 0 2 2 2 0 Nodulation protein NolV BAR_3 PF16746.5 CDW52063.1 - 1 9.0 3.6 8.5 6.0 0.0 3.7 4 0 0 4 4 4 0 BAR domain of APPL family DUF3140 PF11338.8 CDW52063.1 - 3 8.3 8.3 9.9 6.7 0.0 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF3140) Trypsin PF00089.26 CDW52064.1 - 1.1e-115 385.1 2.5 3.3e-58 197.1 0.3 2.2 2 0 0 2 2 2 2 Trypsin Phosphodiest PF01663.22 CDW52064.1 - 8.2e-56 190.1 2.4 1.5e-55 189.2 2.4 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Trypsin_2 PF13365.6 CDW52064.1 - 2.3e-09 38.3 0.0 0.0018 19.2 0.0 2.7 2 0 0 2 2 2 2 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW52064.1 - 0.00019 21.8 0.0 0.37 11.2 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Metalloenzyme PF01676.18 CDW52064.1 - 0.00079 18.9 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 CDW52064.1 - 0.011 15.2 0.0 0.027 13.9 0.0 1.6 1 0 0 1 1 1 0 Sulfatase DUF1501 PF07394.12 CDW52064.1 - 0.2 10.7 0.1 0.73 8.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) HECT PF00632.25 CDW52065.1 - 1.4e-93 313.8 0.5 2.3e-93 313.0 0.5 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 CDW52065.1 - 1e-18 66.1 25.8 7.8e-09 34.7 1.3 4.3 4 0 0 4 4 4 3 Ubiquitin binding region WWE PF02825.20 CDW52065.1 - 1.3e-07 32.1 0.2 5.3e-07 30.1 0.2 2.1 1 0 0 1 1 1 1 WWE domain PPP4R2 PF09184.11 CDW52065.1 - 0.16 11.5 25.4 0.32 10.5 25.4 1.5 1 0 0 1 1 1 0 PPP4R2 RPN2_C PF18004.1 CDW52065.1 - 0.56 10.1 8.6 1.2 9.1 8.6 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF913 PF06025.12 CDW52065.1 - 1.6 7.7 11.3 2.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 CDW52065.1 - 2.5 6.1 36.3 5.1 5.1 36.3 1.5 1 0 0 1 1 1 0 DNA polymerase phi Vfa1 PF08432.10 CDW52065.1 - 9.3 6.5 10.1 20 5.5 10.1 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Amidase PF01425.21 CDW52066.1 - 1.1e-104 351.0 0.0 1.2e-104 350.8 0.0 1.0 1 0 0 1 1 1 1 Amidase Prefoldin_2 PF01920.20 CDW52067.1 - 0.00084 19.3 0.9 0.0013 18.7 0.9 1.2 1 0 0 1 1 1 1 Prefoldin subunit Trypsin PF00089.26 CDW52068.1 - 3.8e-50 170.7 0.0 4.9e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW52068.1 - 1.3e-06 29.3 0.0 2.9e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Metallophos PF00149.28 CDW52069.1 - 4.7e-30 105.6 0.0 6.6e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW52069.1 - 0.09 13.2 0.2 0.22 12.0 0.2 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain SNF PF00209.18 CDW52070.1 - 6.7e-177 589.3 51.6 1.7e-161 538.5 37.1 3.6 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family DUF547 PF04784.14 CDW52070.1 - 0.078 13.0 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF547 SRCR PF00530.18 CDW52071.1 - 9.4e-72 237.9 9.6 1e-26 93.4 1.8 3.7 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Trypsin PF00089.26 CDW52071.1 - 6.7e-64 215.7 1.5 9.1e-64 215.3 0.1 2.0 2 0 0 2 2 2 1 Trypsin Lectin_C PF00059.21 CDW52071.1 - 2.2e-17 63.7 0.5 2.2e-17 63.7 0.5 2.7 2 0 0 2 2 2 1 Lectin C-type domain Kringle PF00051.18 CDW52071.1 - 5.8e-16 58.6 2.7 1.4e-15 57.4 2.7 1.7 1 0 0 1 1 1 1 Kringle domain SRCR_2 PF15494.6 CDW52071.1 - 1.8e-13 50.8 7.7 1.5e-05 25.4 0.3 4.7 5 0 0 5 5 5 3 Scavenger receptor cysteine-rich domain Ldl_recept_a PF00057.18 CDW52071.1 - 5.3e-11 42.5 13.5 5.3e-11 42.5 13.5 3.7 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A PAN_1 PF00024.26 CDW52071.1 - 1.7e-07 31.1 3.4 8.8e-07 28.8 3.4 2.2 1 0 0 1 1 1 1 PAN domain Hepsin-SRCR PF09272.10 CDW52071.1 - 3.1e-05 24.5 0.3 0.14 12.7 0.0 2.8 2 0 0 2 2 2 2 Hepsin, SRCR domain DUF1986 PF09342.11 CDW52071.1 - 0.00052 20.4 0.0 0.0014 19.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Arf PF00025.21 CDW52072.1 - 2.4e-47 160.6 0.2 2.9e-47 160.4 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CDW52072.1 - 1e-18 67.4 0.0 1.2e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52072.1 - 7.3e-17 61.7 0.0 1.1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CDW52072.1 - 7.9e-10 38.5 0.0 9.1e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 CDW52072.1 - 3.2e-09 36.4 0.1 7.6e-06 25.3 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 CDW52072.1 - 1.3e-08 34.9 0.0 5.9e-08 32.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 CDW52072.1 - 1.9e-08 33.9 0.0 2.2e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 CDW52072.1 - 0.0005 20.2 0.3 0.4 10.7 0.2 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 CDW52072.1 - 0.0053 16.3 0.0 0.037 13.6 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain VirE PF05272.11 CDW52072.1 - 0.028 14.1 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E FeoB_N PF02421.18 CDW52072.1 - 0.056 13.0 1.6 0.42 10.1 0.3 2.3 1 1 0 2 2 2 0 Ferrous iron transport protein B ADH_zinc_N PF00107.26 CDW52073.1 - 1.2e-17 64.1 0.0 2.8e-17 62.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW52073.1 - 8.3e-14 51.4 0.0 2.6e-13 49.8 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CDW52073.1 - 5.4e-10 40.4 0.0 3.9e-08 34.4 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CDW52073.1 - 0.034 14.0 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase YhzD PF14120.6 CDW52074.1 - 0.022 14.9 1.0 0.13 12.4 0.1 2.5 2 0 0 2 2 2 0 YhzD-like protein DED PF01335.21 CDW52074.1 - 0.95 9.8 10.0 14 6.1 5.0 3.0 2 1 0 2 2 2 0 Death effector domain GDNF PF02351.16 CDW52074.1 - 2.1 9.3 5.7 1.5 9.9 0.3 2.6 2 1 0 2 2 2 0 GDNF/GAS1 domain Na_Pi_cotrans PF02690.15 CDW52078.1 - 1.1e-33 116.2 24.1 2.5e-23 82.7 6.8 2.9 2 1 0 2 2 2 2 Na+/Pi-cotransporter Transketolase_N PF00456.21 CDW52079.1 - 1.4e-45 155.7 0.0 2.7e-45 154.8 0.0 1.4 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CDW52079.1 - 1.9e-39 135.2 0.0 3.3e-39 134.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDW52079.1 - 1.4e-29 102.5 0.1 3.1e-29 101.4 0.1 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 CDW52079.1 - 1.1e-10 41.0 0.0 1.8e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CDW52079.1 - 5.2e-10 39.0 0.0 2.8e-08 33.3 0.0 2.4 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase XFP_N PF09364.10 CDW52079.1 - 0.00014 20.8 0.0 0.00024 20.0 0.0 1.3 1 0 0 1 1 1 1 XFP N-terminal domain TPP_enzyme_C PF02775.21 CDW52079.1 - 0.0092 15.8 0.1 0.062 13.1 0.1 2.5 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFOR_II PF17147.4 CDW52079.1 - 0.011 16.0 0.1 0.026 14.8 0.1 1.6 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II CCG PF02754.16 CDW52079.1 - 0.11 12.7 0.0 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 Cysteine-rich domain Dala_Dala_lig_C PF07478.13 CDW52080.1 - 0.03 13.9 0.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 D-ala D-ala ligase C-terminus RimK PF08443.11 CDW52080.1 - 0.034 13.8 0.0 0.29 10.7 0.0 2.3 3 0 0 3 3 3 0 RimK-like ATP-grasp domain AAA PF00004.29 CDW52081.1 - 7.8e-14 52.2 0.0 2.8e-13 50.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW52081.1 - 7.1e-07 29.8 0.0 8.1e-05 23.1 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CDW52081.1 - 6.2e-05 22.8 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDW52081.1 - 0.00015 22.0 0.0 0.022 15.1 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CDW52081.1 - 0.00016 21.8 0.0 0.00064 19.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CDW52081.1 - 0.00031 20.8 0.0 0.00071 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CDW52081.1 - 0.0014 18.6 0.0 0.0029 17.6 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 CDW52081.1 - 0.0038 17.0 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_25 PF13481.6 CDW52081.1 - 0.0042 16.7 0.8 0.054 13.1 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 CDW52081.1 - 0.0047 17.5 0.0 0.017 15.7 0.0 1.9 2 0 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 CDW52081.1 - 0.005 16.8 0.0 0.018 15.0 0.0 1.9 1 1 1 2 2 2 1 NTPase dNK PF01712.19 CDW52081.1 - 0.0077 16.1 0.0 2.8 7.7 0.0 2.6 3 0 0 3 3 3 1 Deoxynucleoside kinase RsgA_GTPase PF03193.16 CDW52081.1 - 0.008 16.1 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 CDW52081.1 - 0.009 15.5 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 CDW52081.1 - 0.014 15.6 0.1 0.032 14.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_30 PF13604.6 CDW52081.1 - 0.019 14.7 0.0 0.27 10.9 0.0 2.4 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDW52081.1 - 0.02 14.1 0.0 0.046 12.9 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain TsaE PF02367.17 CDW52081.1 - 0.022 14.7 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CDW52081.1 - 0.027 14.2 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 CDW52081.1 - 0.029 14.2 0.0 0.081 12.8 0.0 1.8 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDW52081.1 - 0.031 14.6 0.0 0.069 13.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_6 PF12774.7 CDW52081.1 - 0.065 12.2 0.0 0.14 11.0 0.0 1.5 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_28 PF13521.6 CDW52081.1 - 0.075 13.3 0.0 0.2 11.9 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_17 PF13207.6 CDW52081.1 - 0.077 13.4 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW52081.1 - 0.1 12.3 0.0 0.24 11.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 CDW52081.1 - 0.11 11.8 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 KaiC NACHT PF05729.12 CDW52081.1 - 0.11 12.4 1.0 0.47 10.3 0.0 2.5 2 2 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 CDW52081.1 - 0.14 12.5 0.5 0.62 10.4 0.1 2.2 2 1 1 3 3 2 0 AAA domain AAA_assoc_2 PF16193.5 CDW52081.1 - 0.15 12.4 0.0 0.46 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain UNC-79 PF14776.6 CDW52083.1 - 5.5e-175 583.1 8.5 5.5e-175 583.1 8.5 3.1 2 1 0 2 2 2 1 Cation-channel complex subunit UNC-79 DUF2722 PF10846.8 CDW52083.1 - 0.057 12.4 5.8 0.093 11.7 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Band_3_cyto PF07565.13 CDW52083.1 - 0.077 12.8 2.8 0.15 11.8 2.8 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SET PF00856.28 CDW52083.1 - 0.09 13.2 0.6 0.39 11.1 0.2 2.2 2 0 0 2 2 2 0 SET domain Ins_P5_2-kin PF06090.12 CDW52083.1 - 0.11 11.9 2.6 0.31 10.4 2.6 1.7 1 0 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase Spt20 PF12090.8 CDW52083.1 - 0.46 10.0 12.0 1 8.9 12.0 1.5 1 0 0 1 1 1 0 Spt20 family ATP11 PF06644.11 CDW52083.1 - 0.82 9.4 8.5 1.8 8.3 8.5 1.5 1 0 0 1 1 1 0 ATP11 protein Pinin_SDK_memA PF04696.13 CDW52083.1 - 0.93 9.6 13.2 2.9 8.0 13.2 1.8 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF4471 PF14740.6 CDW52083.1 - 1.1 8.4 4.1 1.8 7.7 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) DUF4834 PF16118.5 CDW52083.1 - 1.7 9.7 5.0 4.7 8.2 5.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SUIM_assoc PF16619.5 CDW52083.1 - 7.3 6.7 13.5 23 5.1 13.5 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RRM_1 PF00076.22 CDW52084.1 - 1.3e-06 28.1 0.1 0.0012 18.6 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) dCMP_cyt_deam_1 PF00383.23 CDW52085.1 - 5.1e-21 74.4 0.1 9e-21 73.7 0.1 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDW52085.1 - 3.3e-20 72.2 0.0 4.8e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase CSD PF00313.22 CDW52085.1 - 2.6e-07 30.4 0.0 4.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain SNAD4 PF18750.1 CDW52085.1 - 0.00084 19.4 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 Bd3614-deam PF14439.6 CDW52085.1 - 0.0052 16.9 4.4 0.032 14.3 4.4 2.0 1 1 0 1 1 1 1 Bd3614-like deaminase APOBEC2 PF18772.1 CDW52085.1 - 0.01 15.9 0.1 0.016 15.3 0.1 1.2 1 0 0 1 1 1 0 APOBEC2 NAD1 PF18778.1 CDW52085.1 - 0.023 14.8 0.0 0.038 14.1 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 CDW52085.1 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 APOBEC-like N-terminal domain ADH_zinc_N PF00107.26 CDW52086.1 - 2e-19 69.8 0.0 3.4e-19 69.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDW52086.1 - 7.8e-11 43.2 0.0 1.2e-10 42.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW52086.1 - 1.3e-06 28.2 0.0 2.2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ThiF PF00899.21 CDW52086.1 - 0.15 11.4 0.2 0.28 10.5 0.2 1.4 1 0 0 1 1 1 0 ThiF family ASC PF00858.24 CDW52087.1 - 1.3e-45 156.2 5.8 2.7e-34 118.9 1.8 2.1 1 1 1 2 2 2 2 Amiloride-sensitive sodium channel ATPase_gene1 PF09527.10 CDW52087.1 - 0.19 11.9 0.1 0.19 11.9 0.1 2.1 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter NUDIX_2 PF13869.6 CDW52089.1 - 5.5e-76 254.3 0.0 6.3e-76 254.2 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 CDW52089.1 - 0.012 15.7 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 NUDIX domain Vps54 PF07928.12 CDW52089.1 - 0.086 13.3 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Vps54-like protein DUF2977 PF11192.8 CDW52089.1 - 0.13 12.4 0.0 12 6.1 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2977) SH3BP5 PF05276.14 CDW52090.1 - 2.9e-79 266.1 20.2 4.1e-79 265.6 20.2 1.2 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) WW PF00397.26 CDW52090.1 - 1.9e-19 69.4 6.4 3.5e-09 36.6 4.1 2.8 2 0 0 2 2 2 2 WW domain DUF4407 PF14362.6 CDW52090.1 - 0.0033 16.8 12.7 0.048 13.0 2.4 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) DUF4451 PF14616.6 CDW52090.1 - 0.059 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Mu-like_Pro PF10123.9 CDW52090.1 - 0.11 12.1 7.5 0.18 11.3 7.5 1.3 1 0 0 1 1 1 0 Mu-like prophage I protein DUF148 PF02520.17 CDW52090.1 - 4 7.6 10.1 4.6 7.4 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function DUF148 Kunitz_BPTI PF00014.23 CDW52091.1 - 7.8e-47 157.3 42.1 4e-18 65.4 6.5 4.6 4 0 0 4 4 4 4 Kunitz/Bovine pancreatic trypsin inhibitor domain Thyroglobulin_1 PF00086.18 CDW52091.1 - 4.6e-14 51.8 4.5 1.5e-13 50.2 4.5 2.0 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Lustrin_cystein PF14625.6 CDW52091.1 - 1.4e-09 38.1 39.5 0.00041 20.6 4.9 4.8 4 0 0 4 4 4 3 Lustrin, cysteine-rich repeated domain DEAD PF00270.29 CDW52092.1 - 7.6e-51 172.4 0.0 2.6e-49 167.4 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW52092.1 - 3.1e-25 88.7 0.1 4.6e-24 84.9 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 CDW52092.1 - 3.3e-16 59.3 12.0 3.3e-16 59.3 12.0 2.4 2 0 0 2 2 2 1 DBP10CT (NUC160) domain ResIII PF04851.15 CDW52092.1 - 7.6e-06 26.0 0.0 2.2e-05 24.5 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit OATP PF03137.20 CDW52093.1 - 9.7e-132 440.0 20.9 1.2e-131 439.8 20.9 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 CDW52093.1 - 1e-14 54.2 24.0 1.1e-13 50.9 3.5 3.4 4 0 0 4 4 4 2 Major Facilitator Superfamily Kazal_2 PF07648.15 CDW52093.1 - 0.019 15.1 11.3 0.064 13.4 11.3 1.9 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain Col_cuticle_N PF01484.17 CDW52093.1 - 0.13 12.3 0.1 0.13 12.3 0.1 3.3 3 0 0 3 3 3 0 Nematode cuticle collagen N-terminal domain FHA PF00498.26 CDW52095.1 - 6.9e-16 58.4 0.0 1.5e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 FHA domain dsrm PF00035.26 CDW52095.1 - 5.4e-06 27.0 0.0 1.1e-05 26.0 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Yop-YscD_cpl PF16697.5 CDW52095.1 - 0.00013 22.2 0.0 0.00051 20.3 0.0 2.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Dicer_dimer PF03368.14 CDW52095.1 - 0.00017 21.7 0.0 0.0004 20.5 0.0 1.6 1 0 0 1 1 1 1 Dicer dimerisation domain DUF1192 PF06698.11 CDW52095.1 - 0.026 14.6 1.7 0.69 10.0 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PHM7_cyt PF14703.6 CDW52095.1 - 0.15 12.3 1.4 0.29 11.3 1.4 1.5 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter ZapB PF06005.12 CDW52095.1 - 0.18 12.3 7.0 0.45 11.0 5.2 2.7 2 1 0 2 2 2 0 Cell division protein ZapB DUF3450 PF11932.8 CDW52095.1 - 0.47 9.7 6.0 0.88 8.8 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CCDC53 PF10152.9 CDW52095.1 - 1.2 9.6 12.0 1.3 9.5 7.4 2.7 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex Pkinase_Tyr PF07714.17 CDW52096.1 - 3.3e-60 203.6 0.0 4.5e-60 203.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW52096.1 - 2.5e-56 191.0 0.0 5.6e-56 189.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain SH3_1 PF00018.28 CDW52096.1 - 2.6e-09 36.5 0.0 4.8e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CDW52096.1 - 1e-08 34.9 0.3 2e-08 34.0 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CDW52096.1 - 0.00096 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3552 PF12072.8 CDW52096.1 - 0.0023 17.4 8.2 0.0043 16.5 8.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) APH PF01636.23 CDW52096.1 - 0.34 10.8 5.6 0.7 9.8 0.0 2.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family Borrelia_P83 PF05262.11 CDW52096.1 - 0.44 9.0 4.3 0.75 8.2 4.3 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein OmpH PF03938.14 CDW52096.1 - 0.79 10.1 6.8 1.6 9.0 6.8 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.9 CDW52096.1 - 1.2 9.3 13.2 0.4 10.9 8.7 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 GOLD_2 PF13897.6 CDW52098.1 - 2.9e-61 206.0 1.5 2.9e-61 206.0 1.5 1.6 2 0 0 2 2 2 1 Golgi-dynamics membrane-trafficking ACBP PF00887.19 CDW52098.1 - 7.3e-10 38.9 0.0 1.7e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Acyl CoA binding protein GARS_C PF02843.16 CDW52098.1 - 0.067 13.5 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, C domain CobN-Mg_chel PF02514.16 CDW52099.1 - 0.041 11.6 0.0 2.4 5.8 0.0 2.0 2 0 0 2 2 2 0 CobN/Magnesium Chelatase DUF2181 PF10223.9 CDW52100.1 - 2.4e-17 63.2 0.0 3.7e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2181) zf-MYND PF01753.18 CDW52101.1 - 2.2e-06 27.7 15.0 2.2e-06 27.7 15.0 3.0 2 1 0 2 2 2 1 MYND finger zf-CHCC PF10276.9 CDW52101.1 - 0.002 18.2 2.0 0.015 15.3 0.5 2.8 2 0 0 2 2 2 1 Zinc-finger domain Carla_C4 PF01623.17 CDW52101.1 - 0.062 13.3 2.2 0.26 11.3 2.2 2.1 1 0 0 1 1 1 0 Carlavirus putative nucleic acid binding protein TPR_10 PF13374.6 CDW52101.1 - 0.07 13.0 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat ArsA_ATPase PF02374.15 CDW52102.1 - 3.1e-109 364.8 0.1 6.6e-109 363.8 0.1 1.5 1 1 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 CDW52102.1 - 4.2e-12 46.3 0.1 4.2e-11 43.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 CDW52102.1 - 3.8e-10 39.9 0.0 1.1e-09 38.4 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CBP_BcsQ PF06564.12 CDW52102.1 - 1.9e-05 24.3 0.0 5.7e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 CDW52102.1 - 2.4e-05 23.9 0.0 5.1e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 CDW52102.1 - 4e-05 23.3 0.0 0.0013 18.4 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain ParA PF10609.9 CDW52102.1 - 0.0001 21.9 0.0 0.00023 20.7 0.0 1.5 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase NB-ARC PF00931.22 CDW52102.1 - 0.0026 17.0 0.0 0.0038 16.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.6 CDW52102.1 - 0.024 14.2 0.1 0.088 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDW52102.1 - 0.039 14.4 0.0 0.39 11.1 0.0 2.2 2 0 0 2 2 2 0 RNA helicase PhoH PF02562.16 CDW52102.1 - 0.041 13.3 0.0 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 CDW52102.1 - 0.043 13.1 0.0 0.078 12.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin MeaB PF03308.16 CDW52102.1 - 0.051 12.6 0.1 1.3 8.0 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 CDW52102.1 - 0.099 12.1 0.1 0.67 9.4 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 PIF1 PF05970.14 CDW52102.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 PIF1-like helicase ATP_bind_1 PF03029.17 CDW52102.1 - 0.12 12.1 0.2 0.29 10.9 0.2 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 CDW52102.1 - 0.19 12.1 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain BC10 PF06726.12 CDW52103.1 - 4.3e-19 68.5 12.0 5.6e-19 68.1 12.0 1.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 DUF4131 PF13567.6 CDW52103.1 - 0.11 12.2 1.2 0.14 11.8 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) ABC2_membrane_3 PF12698.7 CDW52103.1 - 4.3 6.4 7.1 5.9 5.9 7.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein zf-C2H2 PF00096.26 CDW52105.1 - 2.1e-20 71.9 25.0 1e-06 28.9 1.4 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW52105.1 - 1e-14 53.9 20.6 0.00033 21.3 0.7 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW52105.1 - 1.5e-14 53.7 31.9 6.1e-06 26.4 0.4 4.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW52105.1 - 8.2e-09 35.5 14.7 0.014 15.6 0.5 4.3 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW52105.1 - 4.5e-06 26.5 23.2 0.0034 17.4 2.5 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-RING_7 PF02591.15 CDW52105.1 - 0.0075 16.4 2.6 0.3 11.3 0.1 2.7 2 0 0 2 2 2 1 C4-type zinc ribbon domain zf-C2H2_11 PF16622.5 CDW52105.1 - 0.0083 15.9 12.3 0.21 11.4 0.1 4.3 4 0 0 4 4 4 1 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 CDW52105.1 - 0.014 15.5 13.7 1.2 9.3 3.5 4.3 2 1 2 4 4 4 0 Zinc ribbon domain zf-AN1 PF01428.16 CDW52105.1 - 0.021 15.0 14.4 5.5 7.2 0.5 4.5 4 0 0 4 4 4 0 AN1-like Zinc finger zf-met PF12874.7 CDW52105.1 - 0.024 15.0 17.4 0.16 12.4 0.5 4.3 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 CDW52105.1 - 0.045 13.3 6.5 8.9 6.0 0.1 4.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 CDW52105.1 - 0.047 13.7 10.0 13 6.0 0.2 4.5 4 0 0 4 4 4 0 XPA protein N-terminal zf-C2HE PF16278.5 CDW52105.1 - 0.061 13.8 19.4 3 8.4 1.7 4.2 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.5 CDW52105.1 - 0.065 14.0 0.8 0.065 14.0 0.8 2.8 2 1 0 2 2 2 0 zinc-ribbon family zf-TRAF PF02176.18 CDW52105.1 - 0.085 13.6 11.6 1.5 9.5 4.8 2.5 2 0 0 2 2 2 0 TRAF-type zinc finger ADK_lid PF05191.14 CDW52105.1 - 0.31 11.1 9.4 2.6 8.1 1.2 4.0 3 1 2 5 5 5 0 Adenylate kinase, active site lid CpXC PF14353.6 CDW52105.1 - 0.64 10.1 12.5 7.8 6.6 0.3 4.0 1 1 3 4 4 4 0 CpXC protein LIM PF00412.22 CDW52105.1 - 1.8 8.8 14.9 10 6.4 6.9 3.4 3 0 0 3 3 3 0 LIM domain zf-BED PF02892.15 CDW52105.1 - 2 8.5 19.2 1.1 9.3 0.3 4.1 3 1 1 4 4 4 0 BED zinc finger C1_4 PF07975.12 CDW52105.1 - 3.2 8.1 16.8 2.3 8.5 0.7 3.4 2 1 1 3 3 3 0 TFIIH C1-like domain Fer4_6 PF12837.7 CDW52105.1 - 3.4 7.9 11.1 21 5.4 0.1 4.4 4 0 0 4 4 4 0 4Fe-4S binding domain zf-trcl PF13451.6 CDW52105.1 - 5.7 6.9 10.5 27 4.8 0.2 4.0 4 0 0 4 4 4 0 Probable zinc-ribbon domain 7tm_1 PF00001.21 CDW52106.1 - 4.1e-31 108.3 24.7 5.8e-31 107.8 24.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW52106.1 - 4.8e-06 26.4 17.4 4.8e-06 26.4 17.4 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx E2F_TDP PF02319.20 CDW52107.1 - 6.7e-24 83.7 0.4 1.7e-23 82.4 0.4 1.8 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain RRM_1 PF00076.22 CDW52107.1 - 2.4e-13 49.7 0.0 8.1e-06 25.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) E2F_CC-MB PF16421.5 CDW52107.1 - 5.6e-10 39.4 0.0 1.2e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain RRM_5 PF13893.6 CDW52107.1 - 0.066 12.8 0.0 3.7 7.1 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CDW52107.1 - 0.078 13.1 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 Limkain b1 FERM_M PF00373.18 CDW52108.1 - 6.8e-21 74.9 0.4 1.8e-20 73.5 0.2 1.8 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 CDW52108.1 - 2.6e-16 59.3 0.1 5.4e-16 58.3 0.1 1.6 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 CDW52108.1 - 2.2e-06 27.9 0.0 4.1e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain NOD2_WH PF17779.1 CDW52109.1 - 0.01 16.1 0.5 6.8 7.1 0.0 3.4 3 0 0 3 3 3 0 NOD2 winged helix domain FeS_assembly_P PF01883.19 CDW52110.1 - 4.6e-16 58.7 0.0 8.3e-16 57.9 0.0 1.4 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Peptidase_S8 PF00082.22 CDW52111.1 - 9.8e-68 228.6 0.0 1.5e-67 228.0 0.0 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 CDW52111.1 - 1.4e-48 165.0 0.0 2.6e-48 164.0 0.0 1.3 1 0 0 1 1 1 1 Tripeptidyl peptidase II ComJ PF11033.8 CDW52111.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Competence protein J (ComJ) VASP_tetra PF08776.11 CDW52112.1 - 0.098 12.2 0.2 0.23 11.0 0.2 1.6 1 0 0 1 1 1 0 VASP tetramerisation domain PPR PF01535.20 CDW52112.1 - 0.65 10.4 3.0 18 5.8 0.1 3.9 4 0 0 4 4 4 0 PPR repeat Ribosomal_L22 PF00237.19 CDW52113.1 - 1.6e-40 137.5 0.2 2.7e-40 136.7 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e RasGEF PF00617.19 CDW52114.1 - 2.9e-22 79.7 5.0 1.9e-12 47.7 1.3 3.1 3 1 0 3 3 3 2 RasGEF domain RA PF00788.23 CDW52114.1 - 1.8e-09 38.1 0.1 4.4e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain RasGEF_N PF00618.20 CDW52114.1 - 0.00032 20.9 1.2 0.0024 18.1 0.2 2.5 2 0 0 2 2 2 1 RasGEF N-terminal motif TetR_C_26 PF17934.1 CDW52115.1 - 0.093 13.1 0.2 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Patched PF02460.18 CDW52116.1 - 2.1e-148 495.8 14.9 7.2e-148 494.1 11.8 2.0 1 1 2 3 3 3 3 Patched family Sterol-sensing PF12349.8 CDW52116.1 - 1.5e-35 122.3 0.4 1.5e-35 122.3 0.4 2.7 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation DUF5353 PF17304.2 CDW52116.1 - 0.091 12.5 0.2 0.46 10.3 0.2 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5353) PET122 PF05476.11 CDW52116.1 - 0.13 11.5 1.4 0.38 10.0 0.1 2.1 2 0 0 2 2 2 0 PET122 Slu7 PF11708.8 CDW52117.1 - 7.2e-96 321.0 6.7 1.2e-95 320.4 6.7 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 CDW52117.1 - 0.0094 15.7 0.3 0.02 14.6 0.3 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF4193 PF13834.6 CDW52117.1 - 0.5 10.9 3.9 2.6 8.6 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) zf-C2H2 PF00096.26 CDW52118.1 - 2.2e-22 78.2 57.2 0.00053 20.3 2.3 8.8 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW52118.1 - 1e-08 35.2 55.8 0.1 13.5 0.9 9.3 9 0 0 9 9 9 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW52118.1 - 2.1e-06 27.9 26.8 0.033 14.5 2.0 7.0 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 CDW52118.1 - 0.00017 21.2 2.7 0.00017 21.2 2.7 6.0 7 0 0 7 7 7 1 C2H2-type zinc-finger domain zf-met PF12874.7 CDW52118.1 - 0.001 19.4 31.0 0.63 10.5 0.1 7.4 7 0 0 7 7 7 3 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 CDW52118.1 - 0.0025 18.1 27.7 3.3 8.1 0.1 5.9 5 0 0 5 5 5 3 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 CDW52118.1 - 0.019 15.4 2.5 0.019 15.4 2.5 7.2 8 0 0 8 8 8 0 Zinc-finger double domain zf-C2H2_3rep PF18868.1 CDW52118.1 - 0.19 12.4 22.6 0.17 12.6 5.3 5.5 4 2 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 CDW52118.1 - 0.58 10.5 38.0 3.5 8.0 5.1 6.5 5 2 2 7 7 7 0 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 CDW52118.1 - 3 8.1 7.1 8.5 6.6 0.5 3.9 4 0 0 4 4 4 0 A-kinase anchoring protein 95 (AKAP95) Ribosomal_L10 PF00466.20 CDW52119.1 - 1.7e-21 76.2 1.0 1.1e-19 70.5 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 CDW52119.1 - 2.6e-21 75.4 0.2 1e-20 73.5 0.1 1.9 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 CDW52119.1 - 4.3e-15 56.1 9.0 4.3e-15 56.1 9.0 1.8 2 0 0 2 2 2 1 60s Acidic ribosomal protein Ribonuc_L-PSP PF01042.21 CDW52119.1 - 0.074 13.1 0.0 0.34 10.9 0.1 2.0 2 0 0 2 2 2 0 Endoribonuclease L-PSP FAD_binding_2 PF00890.24 CDW52121.1 - 5.5e-122 407.8 5.9 7.7e-122 407.4 5.9 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CDW52121.1 - 4.6e-41 139.8 0.3 6.8e-41 139.2 0.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Thi4 PF01946.17 CDW52121.1 - 8.8e-06 25.1 1.9 0.0035 16.6 0.1 2.6 3 0 0 3 3 3 2 Thi4 family Pyr_redox_2 PF07992.14 CDW52121.1 - 0.00015 21.1 1.9 0.00026 20.3 0.9 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDW52121.1 - 0.00027 20.2 4.3 0.012 14.7 3.2 2.5 3 0 0 3 3 3 1 Glucose inhibited division protein A DAO PF01266.24 CDW52121.1 - 0.00032 20.4 0.4 0.00067 19.3 0.2 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CDW52121.1 - 0.00039 19.8 1.0 0.00062 19.1 1.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CDW52121.1 - 0.009 14.8 0.9 0.029 13.1 0.1 2.2 3 0 0 3 3 3 1 HI0933-like protein Lycopene_cycl PF05834.12 CDW52121.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 CDW52121.1 - 0.69 9.2 4.9 1.8 7.8 4.9 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase PS_Dcarbxylase PF02666.15 CDW52122.1 - 3.9e-55 186.5 0.0 4.6e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase LIF_OSM PF01291.17 CDW52123.1 - 0.011 15.9 0.1 0.013 15.7 0.1 1.1 1 0 0 1 1 1 0 LIF / OSM family Thioredoxin PF00085.20 CDW52124.1 - 5.8e-61 202.9 0.0 1.5e-30 105.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 CDW52124.1 - 9.6e-08 31.7 0.0 0.00012 21.6 0.0 2.8 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 CDW52124.1 - 6.7e-06 26.0 0.1 0.021 14.7 0.0 2.9 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_2 PF13098.6 CDW52124.1 - 1.1e-05 25.9 3.0 0.11 12.9 0.2 3.9 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDW52124.1 - 1.2e-05 25.5 0.0 0.36 11.2 0.0 3.4 2 2 2 4 4 4 2 Thioredoxin-like Thioredoxin_6 PF13848.6 CDW52124.1 - 3e-05 24.0 0.0 2.8 7.8 0.0 3.8 4 1 1 5 5 5 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDW52124.1 - 0.00043 20.4 0.0 0.2 11.8 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.6 CDW52124.1 - 0.00096 18.9 0.0 0.26 11.1 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 CDW52124.1 - 0.0026 17.7 0.0 0.28 11.3 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin domain TraF PF13728.6 CDW52124.1 - 0.008 16.0 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 CDW52124.1 - 0.0084 16.3 0.0 2 8.6 0.0 2.7 2 1 0 2 2 2 1 Thioredoxin TAF4 PF05236.14 CDW52125.1 - 7.3e-27 94.8 6.8 1.6e-26 93.7 0.2 2.8 3 0 0 3 3 3 1 Transcription initiation factor TFIID component TAF4 family TAFH PF07531.14 CDW52125.1 - 1.3e-17 63.7 0.1 1.3e-17 63.7 0.1 2.6 2 0 0 2 2 2 1 NHR1 homology to TAF RRM_1 PF00076.22 CDW52126.1 - 1.6e-13 50.2 0.0 2.2e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Arrestin_N PF00339.29 CDW52127.1 - 4.8e-23 81.8 0.0 1.3e-20 74.0 0.0 2.9 2 1 1 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CDW52127.1 - 8.8e-17 61.8 0.0 3.4e-15 56.7 0.0 2.6 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 CDW52127.1 - 3.6e-05 23.1 1.2 0.012 14.8 0.1 2.4 1 1 2 3 3 3 2 Rgp1 Vps26 PF03643.15 CDW52127.1 - 0.17 10.8 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 26 Ldl_recept_a PF00057.18 CDW52128.1 - 1.8e-17 63.3 40.2 2e-06 27.9 2.1 4.0 4 0 0 4 4 4 3 Low-density lipoprotein receptor domain class A Ral PF11058.8 CDW52128.1 - 3.3 7.3 6.1 0.45 10.1 1.6 1.9 2 0 0 2 2 2 0 Antirestriction protein Ral Ion_trans PF00520.31 CDW52129.1 - 1.6e-30 106.2 10.7 2.2e-30 105.7 10.7 1.1 1 0 0 1 1 1 1 Ion transport protein KCNQ_channel PF03520.14 CDW52129.1 - 7.4e-29 100.9 0.4 1.6e-28 99.9 0.4 1.5 1 1 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans_2 PF07885.16 CDW52129.1 - 2.9e-14 52.8 3.8 2.9e-14 52.8 3.8 1.9 2 0 0 2 2 2 1 Ion channel 7TMR-DISM_7TM PF07695.11 CDW52129.1 - 8.9 6.1 13.4 2.3 8.0 3.1 2.3 2 0 0 2 2 2 0 7TM diverse intracellular signalling LepB_GAP_C PF18227.1 CDW52130.1 - 0.014 15.9 0.7 0.032 14.7 0.7 1.6 1 0 0 1 1 1 0 LepB GAP domain C-terminal subdomain DUF5054 PF16477.5 CDW52130.1 - 0.015 15.1 0.5 0.019 14.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5054) TPR_2 PF07719.17 CDW52131.1 - 1.5e-19 68.4 0.9 2.7e-05 24.0 0.1 8.0 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDW52131.1 - 7.9e-16 57.1 0.2 6.3e-05 22.6 0.1 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDW52131.1 - 1.7e-15 57.0 5.9 0.0095 16.2 0.8 6.8 6 2 1 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52131.1 - 3.6e-12 45.5 5.9 0.024 14.8 0.0 7.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52131.1 - 4e-12 45.3 8.9 0.24 11.5 0.0 8.2 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDW52131.1 - 1.2e-11 44.4 8.2 0.017 15.9 0.1 8.1 7 2 2 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDW52131.1 - 1.3e-09 37.8 2.4 0.02 15.3 0.0 7.2 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW52131.1 - 2e-09 37.9 3.6 5.3e-05 23.8 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW52131.1 - 2.9e-09 37.3 5.6 5.3e-05 23.6 0.1 5.0 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW52131.1 - 3e-09 36.4 7.0 0.0003 20.4 0.1 6.0 6 1 1 7 7 7 3 TPR repeat ANAPC3 PF12895.7 CDW52131.1 - 2.3e-08 34.1 1.0 0.0029 17.8 0.1 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 CDW52131.1 - 1.5e-06 28.2 0.4 0.0025 17.9 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW52131.1 - 5.8e-05 23.5 5.8 17 6.3 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDW52131.1 - 6.2e-05 23.3 0.1 4.6 8.2 0.0 5.2 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDW52131.1 - 0.00012 21.4 1.3 1.2 8.2 0.0 4.0 3 1 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW52131.1 - 0.031 14.3 0.4 0.17 12.0 0.1 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 CDW52131.1 - 0.045 13.6 8.0 20 5.2 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TetR_C_15 PF17918.1 CDW52131.1 - 0.096 13.4 0.0 0.22 12.3 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TPR_20 PF14561.6 CDW52131.1 - 0.28 11.6 0.6 6.6 7.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Ncstrn_small PF18266.1 CDW52132.1 - 5.2e-46 156.7 0.1 8.6e-46 156.0 0.1 1.4 1 0 0 1 1 1 1 Nicastrin small lobe Nicastrin PF05450.15 CDW52132.1 - 2.7e-40 138.3 0.4 6.3e-40 137.1 0.2 1.6 2 0 0 2 2 2 1 Nicastrin HCV_core PF01542.18 CDW52133.1 - 0.049 14.0 0.1 0.1 13.0 0.1 1.5 1 0 0 1 1 1 0 Hepatitis C virus core protein zf-C2H2_jaz PF12171.8 CDW52133.1 - 0.058 13.7 2.2 3.1 8.2 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CDW52133.1 - 0.073 13.6 11.6 0.19 12.3 0.5 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW52133.1 - 3.7 8.6 11.7 8.9 7.5 0.4 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger DUF4481 PF14800.6 CDW52134.1 - 5.6e-05 22.8 11.3 0.034 13.6 0.1 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4481) Vps52 PF04129.12 CDW52135.1 - 2.3e-106 356.6 8.7 3.1e-106 356.1 8.7 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 CDW52135.1 - 7.3e-05 21.4 8.4 0.00067 18.2 2.4 2.2 2 0 0 2 2 2 2 Exocyst complex component Sec3 Gypsy PF07253.11 CDW52135.1 - 0.031 12.8 0.2 0.05 12.2 0.2 1.2 1 0 0 1 1 1 0 Gypsy protein Oxidored_molyb PF00174.19 CDW52136.1 - 6.3e-60 201.7 0.0 1.5e-59 200.4 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CDW52136.1 - 3.6e-37 127.5 0.4 8.4e-37 126.3 0.4 1.7 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 CDW52136.1 - 1e-10 41.6 0.0 1.8e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TerD PF02342.18 CDW52136.1 - 0.037 13.5 0.0 0.069 12.6 0.0 1.3 1 0 0 1 1 1 0 TerD domain A2M_BRD PF07703.14 CDW52136.1 - 0.15 12.5 0.0 3.6 7.9 0.0 2.5 2 0 0 2 2 2 0 Alpha-2-macroglobulin bait region domain BNR PF02012.20 CDW52136.1 - 0.85 9.9 4.7 0.36 11.0 0.3 2.9 3 0 0 3 3 3 0 BNR/Asp-box repeat SnoaL_2 PF12680.7 CDW52137.1 - 0.00038 21.1 0.0 0.00048 20.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 CDW52137.1 - 0.092 13.0 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain 7tm_1 PF00001.21 CDW52138.1 - 4.7e-46 157.2 19.2 6.4e-46 156.8 19.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW52138.1 - 2.7e-12 46.6 16.3 6e-12 45.5 16.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW52138.1 - 7.6e-07 29.0 16.9 7.6e-07 29.0 16.9 1.8 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 CDW52138.1 - 6.9e-06 26.0 11.9 1.3e-05 25.1 11.9 1.4 1 0 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srw PF10324.9 CDW52138.1 - 0.0092 15.3 16.9 0.018 14.3 16.9 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw Cullin PF00888.22 CDW52139.1 - 8.6e-11 41.2 0.1 1.8e-10 40.1 0.1 1.5 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 CDW52139.1 - 0.00028 21.3 1.3 0.0013 19.2 1.3 2.2 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 zf-C2H2_4 PF13894.6 CDW52139.1 - 0.54 11.2 6.7 0.081 13.8 0.9 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger POT1PC PF16686.5 CDW52140.1 - 1.2e-15 57.7 0.0 4.5e-15 55.9 0.0 1.8 2 0 0 2 2 2 1 ssDNA-binding domain of telomere protection protein adh_short_C2 PF13561.6 CDW52141.1 - 1.8e-43 148.8 5.4 4.4e-41 141.0 5.4 2.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDW52141.1 - 1.4e-41 142.1 3.2 2.7e-41 141.2 3.2 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDW52141.1 - 1.7e-10 41.1 0.1 4.1e-08 33.4 0.0 2.2 1 1 1 2 2 2 2 KR domain 2-Hacid_dh_C PF02826.19 CDW52141.1 - 0.0034 16.8 0.0 0.006 16.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Eno-Rase_NADH_b PF12242.8 CDW52141.1 - 0.043 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Peptidase_M20 PF01546.28 CDW52142.1 - 9.2e-14 51.6 0.0 1.3e-11 44.6 0.0 2.1 1 1 0 2 2 2 2 Peptidase family M20/M25/M40 Endonuc-FokI_C PF09254.11 CDW52142.1 - 0.068 12.4 0.1 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Restriction endonuclease FokI, C terminal 7tm_1 PF00001.21 CDW52143.1 - 1.4e-66 224.5 6.0 1.7e-66 224.2 6.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW52143.1 - 2.1e-12 47.0 15.0 1e-08 34.9 8.0 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Aa_trans PF01490.18 CDW52144.1 - 2.9e-108 362.2 55.3 4.4e-59 200.2 24.9 3.2 2 1 1 3 3 3 3 Transmembrane amino acid transporter protein DUF5600 PF18150.1 CDW52145.1 - 5.4e-12 46.2 1.3 1.4e-11 44.9 1.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) Dynamin_N PF00350.23 CDW52145.1 - 2.3e-09 37.5 0.0 6.5e-08 32.8 0.0 2.4 1 1 0 1 1 1 1 Dynamin family EF-hand_4 PF12763.7 CDW52145.1 - 3.6e-08 33.3 0.1 1.2e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand MMR_HSR1 PF01926.23 CDW52145.1 - 1.3e-05 25.2 0.0 4.2e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase EHD_N PF16880.5 CDW52145.1 - 0.0011 18.7 1.6 0.0022 17.9 0.0 2.2 2 0 0 2 2 2 1 N-terminal EH-domain containing protein cobW PF02492.19 CDW52145.1 - 0.0039 16.8 0.1 0.69 9.5 0.0 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain EF-hand_1 PF00036.32 CDW52145.1 - 0.015 14.8 0.0 0.041 13.4 0.0 1.8 1 0 0 1 1 1 0 EF hand MMR_HSR1_Xtn PF16897.5 CDW52145.1 - 0.051 13.6 0.2 0.23 11.5 0.2 2.1 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 CDW52145.1 - 0.13 11.6 0.8 3.8 6.8 0.2 2.5 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region ECH_1 PF00378.20 CDW52146.1 - 1.2e-45 155.8 0.0 2.9e-45 154.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDW52146.1 - 6.3e-31 108.1 0.0 1.1e-30 107.3 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase WD40 PF00400.32 CDW52147.1 - 6e-37 125.0 12.1 4e-06 27.5 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52147.1 - 2.2e-11 43.9 0.0 0.0023 18.2 0.0 4.6 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW52147.1 - 2.7e-06 26.6 0.3 1.7 7.6 0.0 4.5 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cerato-platanin PF07249.12 CDW52147.1 - 0.015 15.4 0.1 4.1 7.6 0.0 2.7 3 0 0 3 3 3 0 Cerato-platanin PD40 PF07676.12 CDW52147.1 - 0.082 12.9 0.0 13 5.8 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF948 PF06103.11 CDW52147.1 - 0.18 12.1 0.1 17 5.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Vps51 PF08700.11 CDW52148.1 - 5.1e-10 39.3 0.8 1.9e-09 37.5 0.2 2.3 2 0 0 2 2 2 1 Vps51/Vps67 Dak2 PF02734.17 CDW52148.1 - 0.013 15.5 0.1 0.034 14.0 0.1 1.7 1 0 0 1 1 1 0 DAK2 domain FHA PF00498.26 CDW52149.1 - 9.3e-17 61.2 0.0 1.7e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CDW52149.1 - 0.0012 19.1 0.0 0.0055 17.0 0.0 2.0 1 1 1 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain CAF-1_p150 PF11600.8 CDW52149.1 - 0.033 13.9 1.3 0.054 13.2 1.3 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Spc7 PF08317.11 CDW52149.1 - 0.077 11.9 8.5 0.11 11.3 8.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein LMBR1 PF04791.16 CDW52149.1 - 0.15 10.9 0.9 0.2 10.5 0.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein MCC-bdg_PDZ PF10506.9 CDW52149.1 - 0.15 12.1 7.2 0.11 12.6 4.1 2.3 1 1 1 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Mod_r PF07200.13 CDW52149.1 - 0.77 9.9 9.6 1.1 9.4 6.9 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 CDW52149.1 - 1.6 9.4 6.2 72 4.1 6.2 2.3 1 1 0 1 1 1 0 Initiation control protein YabA MCU PF04678.13 CDW52150.1 - 7.1e-50 169.5 1.4 1e-49 169.0 1.4 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF5320 PF17253.2 CDW52150.1 - 9.7 7.3 6.1 31 5.7 0.6 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5320) Sld5 PF05916.11 CDW52151.1 - 1.8e-20 73.4 0.6 2.7e-20 72.8 0.6 1.3 1 0 0 1 1 1 1 GINS complex protein Cofilin_ADF PF00241.20 CDW52152.1 - 4.1e-27 94.4 0.0 6.8e-13 48.5 0.0 2.5 3 0 0 3 3 3 2 Cofilin/tropomyosin-type actin-binding protein WD40 PF00400.32 CDW52153.1 - 4e-07 30.6 4.6 0.0024 18.7 0.2 4.4 5 0 0 5 5 5 2 WD domain, G-beta repeat Hira PF07569.11 CDW52153.1 - 0.14 11.8 0.1 0.78 9.4 0.0 2.1 2 0 0 2 2 2 0 TUP1-like enhancer of split AI-2E_transport PF01594.16 CDW52154.1 - 5.5e-12 45.5 12.9 5.5e-12 45.5 12.9 3.2 3 0 0 3 3 3 2 AI-2E family transporter IFT81_CH PF18383.1 CDW52155.1 - 1.4e-12 47.9 0.2 5.4e-12 46.1 0.0 2.1 2 0 0 2 2 2 1 Intraflagellar transport 81 calponin homology domain DASH_Duo1 PF08651.10 CDW52155.1 - 0.098 12.4 3.5 5.2 6.9 0.4 3.9 5 0 0 5 5 4 0 DASH complex subunit Duo1 Syntaxin_2 PF14523.6 CDW52155.1 - 0.11 12.8 15.0 0.3 11.5 2.9 3.9 3 1 0 4 4 4 0 Syntaxin-like protein Sec34 PF04136.15 CDW52155.1 - 0.17 11.7 10.1 0.03 14.2 4.0 2.4 1 1 0 2 2 2 0 Sec34-like family Syntaxin-6_N PF09177.11 CDW52155.1 - 0.18 12.4 14.5 4.1 8.0 9.1 4.0 1 1 2 3 3 3 0 Syntaxin 6, N-terminal SpecificRecomb PF10136.9 CDW52155.1 - 0.26 9.5 4.2 0.42 8.9 4.2 1.4 1 0 0 1 1 1 0 Site-specific recombinase TFA2_Winged_2 PF18121.1 CDW52155.1 - 0.36 10.5 1.8 1.6 8.4 0.0 2.6 3 0 0 3 3 3 0 TFA2 Winged helix domain 2 BLOC1_2 PF10046.9 CDW52155.1 - 0.59 10.5 11.5 0.72 10.2 2.3 3.8 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHR10 PF18595.1 CDW52155.1 - 0.69 10.0 33.4 2 8.5 10.8 4.2 2 2 1 3 3 3 0 Designed helical repeat protein 10 domain DUF1664 PF07889.12 CDW52155.1 - 0.75 9.8 11.1 0.55 10.3 1.5 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) DUF501 PF04417.12 CDW52155.1 - 1.1 9.1 4.0 1.6 8.6 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF501) Flagellin_N PF00669.20 CDW52155.1 - 1.4 9.0 6.1 2.2 8.4 1.2 2.9 2 1 1 3 3 3 0 Bacterial flagellin N-terminal helical region Hemerythrin PF01814.23 CDW52155.1 - 1.6 9.3 7.3 5.4 7.6 4.4 3.0 2 1 0 2 2 2 0 Hemerythrin HHE cation binding domain Prominin PF05478.11 CDW52155.1 - 1.7 6.5 11.5 2.4 6.0 11.5 1.1 1 0 0 1 1 1 0 Prominin STAT_alpha PF01017.20 CDW52155.1 - 2.4 8.0 14.3 0.53 10.2 5.6 2.9 3 1 0 3 3 3 0 STAT protein, all-alpha domain Fez1 PF06818.15 CDW52155.1 - 2.7 8.4 19.3 1.1 9.6 13.1 2.5 1 1 2 3 3 3 0 Fez1 Phage_Mu_Gam PF07352.12 CDW52155.1 - 4.2 7.3 11.4 3 7.7 0.3 2.9 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein KfrA_N PF11740.8 CDW52155.1 - 5.2 7.8 15.6 2 9.1 0.5 3.7 2 2 1 3 3 3 0 Plasmid replication region DNA-binding N-term CHD5 PF04420.14 CDW52155.1 - 5.8 6.8 5.3 3.7 7.4 0.1 2.9 2 1 1 3 3 3 0 CHD5-like protein Csm1_N PF18504.1 CDW52155.1 - 6.2 7.2 15.7 0.62 10.4 0.6 4.4 3 1 1 4 4 4 0 Csm1 N-terminal domain SlyX PF04102.12 CDW52155.1 - 9.1 7.0 20.7 4.4 8.0 0.3 5.3 2 1 4 6 6 6 0 SlyX Phosphorylase PF00343.20 CDW52156.1 - 3.7e-300 997.3 0.0 2.7e-161 538.3 0.0 2.4 2 1 1 3 3 3 2 Carbohydrate phosphorylase DUF3417 PF11897.8 CDW52156.1 - 0.39 11.2 1.5 9.3 6.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3417) LSM PF01423.22 CDW52157.1 - 1.3e-07 31.2 0.0 2.2e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 LSM domain PTAC PF06130.12 CDW52157.1 - 0.085 13.0 0.0 2.5 8.3 0.0 2.0 1 1 1 2 2 2 0 Phosphate propanoyltransferase Coq4 PF05019.13 CDW52158.1 - 7.9e-83 277.1 0.0 1.1e-82 276.7 0.0 1.2 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 zf-DNL PF05180.12 CDW52158.1 - 1.2e-27 95.6 0.1 2.3e-27 94.7 0.1 1.5 1 0 0 1 1 1 1 DNL zinc finger Ribosomal_S13_N PF08069.12 CDW52158.1 - 2e-20 72.6 0.0 4e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 CDW52158.1 - 1.9e-14 53.6 1.0 3.7e-14 52.7 1.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 CDW52158.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 'Paired box' domain Fcf2 PF08698.11 CDW52159.1 - 1.2e-32 112.1 1.5 2.5e-32 111.1 1.5 1.5 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing PRODH PF18327.1 CDW52159.1 - 0.031 14.5 1.1 3.3 8.0 0.1 2.6 2 0 0 2 2 2 0 Proline utilization A proline dehydrogenase N-terminal domain Pex14_N PF04695.13 CDW52160.1 - 2.4 8.8 12.3 4.1 8.0 12.3 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Dicty_REP PF05086.12 CDW52160.1 - 4.8 5.0 11.3 6.3 4.6 11.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein HEAT PF02985.22 CDW52161.1 - 3.3e-09 36.2 21.7 0.06 13.6 0.3 8.6 7 0 0 7 7 7 3 HEAT repeat Vac14_Fab1_bd PF12755.7 CDW52161.1 - 0.00047 20.7 0.2 3.5 8.3 0.0 4.2 2 1 1 3 3 3 2 Vacuolar 14 Fab1-binding region IFRD PF05004.13 CDW52161.1 - 0.0016 17.6 8.9 0.26 10.4 3.6 4.1 4 0 0 4 4 4 2 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 CDW52161.1 - 0.0016 18.9 20.8 2.8 8.6 0.1 9.7 9 0 0 9 9 9 2 HEAT-like repeat Proteasom_PSMB PF10508.9 CDW52161.1 - 0.039 12.5 0.7 0.58 8.6 0.2 2.8 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit CobD_Cbib PF03186.13 CDW52161.1 - 0.066 12.4 1.3 0.11 11.7 0.0 2.0 2 0 0 2 2 2 0 CobD/Cbib protein CLASP_N PF12348.8 CDW52161.1 - 0.073 12.6 6.0 0.63 9.6 0.3 4.1 5 0 0 5 5 5 0 CLASP N terminal RTP1_C1 PF10363.9 CDW52161.1 - 0.095 12.9 0.6 6.7 6.9 0.1 4.0 3 2 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 CDW52161.1 - 2 8.6 7.1 6.1 7.0 0.2 4.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Ribosomal_L13e PF01294.18 CDW52162.1 - 2.9e-80 268.3 8.0 3.5e-80 268.1 8.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L13e Epimerase PF01370.21 CDW52163.1 - 6.7e-51 173.1 0.0 9.1e-51 172.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CDW52163.1 - 5.4e-16 58.9 0.1 3.4e-15 56.3 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CDW52163.1 - 2.7e-06 26.7 0.0 0.054 12.6 0.0 3.1 3 0 0 3 3 3 3 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDW52163.1 - 0.0002 20.6 0.0 0.00036 19.7 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CDW52163.1 - 0.0069 15.4 0.0 0.071 12.1 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NICE-3 PF07406.11 CDW52163.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 NICE-3 protein VPS9 PF02204.18 CDW52164.1 - 6.9e-13 48.7 0.0 1.3e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SH2 PF00017.24 CDW52164.1 - 1.3e-08 34.8 0.0 3.8e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 SH2 domain Sde2_N_Ubi PF13019.6 CDW52165.1 - 2.6e-14 53.4 0.5 3.1e-14 53.1 0.5 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Thioredoxin PF00085.20 CDW52166.1 - 1.3e-13 50.8 0.0 2e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Zip PF02535.22 CDW52166.1 - 0.00018 20.9 0.0 0.00022 20.6 0.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter NapE PF06796.11 CDW52166.1 - 0.0019 17.7 1.7 0.0022 17.5 0.0 1.9 2 0 0 2 2 2 1 Periplasmic nitrate reductase protein NapE DUF4834 PF16118.5 CDW52166.1 - 0.13 13.2 0.0 0.22 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Gal-bind_lectin PF00337.22 CDW52167.1 - 1.7e-54 183.0 0.0 8.9e-30 103.0 0.0 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin adh_short PF00106.25 CDW52168.1 - 8.9e-20 71.0 0.2 3.3e-19 69.1 0.2 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW52168.1 - 1.3e-13 51.1 0.0 8.2e-13 48.5 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW52168.1 - 3e-10 40.3 0.1 5.3e-10 39.5 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDW52168.1 - 0.0029 17.1 0.0 0.005 16.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family FeoB_N PF02421.18 CDW52168.1 - 0.025 14.1 0.1 0.057 12.9 0.1 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B Polysacc_synt_2 PF02719.15 CDW52168.1 - 0.047 12.8 0.0 0.07 12.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ion_trans_2 PF07885.16 CDW52169.1 - 1.3e-33 114.8 17.8 2.2e-18 66.0 1.7 3.8 3 1 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CDW52169.1 - 3.8e-07 29.6 8.0 6.8e-05 22.2 1.4 2.2 2 0 0 2 2 2 2 Ion transport protein Tetraspanin PF00335.20 CDW52169.1 - 0.061 13.0 3.2 0.37 10.5 0.1 2.3 2 0 0 2 2 2 0 Tetraspanin family TrbI_Ftype PF09677.10 CDW52169.1 - 0.12 12.7 0.2 0.22 11.9 0.2 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system protein (TrbI_Ftype) Globin PF00042.22 CDW52170.1 - 2e-07 31.6 0.0 3e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Globin Ank_2 PF12796.7 CDW52171.1 - 5e-18 65.5 0.4 1e-08 35.7 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW52171.1 - 1.1e-12 46.9 3.5 0.022 15.2 0.1 6.1 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 CDW52171.1 - 1e-11 44.7 2.2 0.0038 17.6 0.0 6.0 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 CDW52171.1 - 2.4e-11 43.9 3.4 1.2e-06 29.0 0.0 4.3 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ion_trans PF00520.31 CDW52171.1 - 4.8e-10 39.1 24.2 9.1e-10 38.2 24.2 1.5 1 0 0 1 1 1 1 Ion transport protein Ank_5 PF13857.6 CDW52171.1 - 2.3e-09 37.3 4.6 1.7e-05 25.0 0.2 4.7 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Peptidase_C2 PF00648.21 CDW52172.1 - 4.6e-117 390.3 0.0 5.7e-117 390.0 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 CDW52172.1 - 1.1e-37 129.4 0.0 1.8e-37 128.7 0.0 1.3 1 0 0 1 1 1 1 Calpain large subunit, domain III OGG_N PF07934.12 CDW52173.1 - 3.8e-14 52.8 0.0 6.8e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 CDW52173.1 - 3.9e-13 49.8 0.0 5.5e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDW52173.1 - 0.00054 19.7 0.1 0.0019 18.0 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif Spectrin PF00435.21 CDW52174.1 - 0 1359.8 235.1 5.3e-25 87.9 4.6 22.1 22 0 0 22 22 22 21 Spectrin repeat EFhand_Ca_insen PF08726.10 CDW52174.1 - 4e-24 84.5 1.8 1.2e-23 83.0 0.1 3.0 3 0 0 3 3 2 1 Ca2+ insensitive EF hand SH3_1 PF00018.28 CDW52174.1 - 1.5e-15 56.5 1.5 2.9e-15 55.6 0.0 2.2 2 0 0 2 2 2 1 SH3 domain EF-hand_1 PF00036.32 CDW52174.1 - 1.2e-11 43.3 0.2 0.00024 20.4 0.1 3.4 2 0 0 2 2 2 2 EF hand SH3_9 PF14604.6 CDW52174.1 - 4.3e-11 42.5 0.6 8.2e-11 41.6 0.0 1.9 2 0 0 2 2 1 1 Variant SH3 domain EF-hand_7 PF13499.6 CDW52174.1 - 4.5e-10 39.8 0.1 1.9e-08 34.6 0.1 4.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDW52174.1 - 7.3e-09 34.9 0.0 0.0011 18.8 0.1 4.4 3 0 0 3 3 3 2 EF-hand domain SH3_2 PF07653.17 CDW52174.1 - 1.7e-07 30.8 0.0 3.8e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_8 PF13833.6 CDW52174.1 - 0.00014 21.7 1.3 0.0088 15.9 0.0 4.0 3 1 1 4 4 4 1 EF-hand domain pair SH3_3 PF08239.11 CDW52174.1 - 0.00019 21.7 0.2 0.001 19.3 0.0 2.3 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_10 PF17902.1 CDW52174.1 - 0.014 15.4 0.0 0.046 13.8 0.0 1.9 1 0 0 1 1 1 0 SH3 domain ApoLp-III PF07464.11 CDW52174.1 - 0.046 13.8 0.1 0.046 13.8 0.1 9.5 10 1 0 10 10 8 0 Apolipophorin-III precursor (apoLp-III) PX PF00787.24 CDW52174.1 - 0.082 12.9 1.4 2.9 7.9 0.2 3.4 2 0 0 2 2 2 0 PX domain DUF5616 PF18481.1 CDW52174.1 - 0.34 11.2 3.5 37 4.6 0.0 5.4 6 0 0 6 6 5 0 Domain of unknown function (DUF5616) TRAF_BIRC3_bd PF16673.5 CDW52174.1 - 1.2 8.9 8.6 15 5.5 0.0 5.8 4 0 0 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain DUF1940 PF09155.10 CDW52174.1 - 1.8 8.7 12.2 1.1 9.4 1.0 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1940) zf-MIZ PF02891.20 CDW52174.1 - 3.9 7.3 5.3 21 5.0 0.4 2.5 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger GvpG PF05120.12 CDW52174.1 - 8 6.6 22.0 0.86 9.7 0.4 5.9 5 0 0 5 5 4 0 Gas vesicle protein G HSP20 PF00011.21 CDW52175.1 - 0.00022 21.3 0.0 0.00061 19.9 0.0 1.7 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Telomerase_RBD PF12009.8 CDW52175.1 - 0.24 11.5 2.8 0.23 11.6 1.8 1.6 1 1 0 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain LNS2 PF08235.13 CDW52176.1 - 1e-92 309.7 0.0 1.5e-92 309.1 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 CDW52176.1 - 5e-34 116.3 0.0 9.2e-34 115.5 0.0 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region WRNPLPNID PF15017.6 CDW52176.1 - 0.35 11.8 0.1 0.35 11.8 0.1 2.0 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box GPI2 PF06432.11 CDW52177.1 - 1.1e-59 202.1 19.5 1.3e-59 202.0 19.5 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Mito_carr PF00153.27 CDW52178.1 - 1.9e-72 239.3 1.5 9.4e-25 86.4 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 CDW52178.1 - 2.7e-11 43.7 0.0 2.3e-05 24.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW52178.1 - 1.1e-10 40.3 0.4 3.9e-05 22.9 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CDW52178.1 - 3e-10 39.2 0.1 6.6e-05 22.5 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CDW52178.1 - 2e-05 24.4 0.0 0.011 15.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CDW52178.1 - 8.8e-05 21.8 1.0 0.079 12.5 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 CDW52178.1 - 0.00024 21.3 0.1 0.02 15.2 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_10 PF14788.6 CDW52178.1 - 0.028 14.3 0.1 0.16 11.9 0.1 2.2 2 0 0 2 2 2 0 EF hand UcrQ PF02939.16 CDW52178.1 - 0.028 14.3 0.1 19 5.3 0.0 3.2 3 0 0 3 3 3 0 UcrQ family EF-hand_11 PF08976.11 CDW52178.1 - 0.094 13.6 0.0 0.21 12.4 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Cullin PF00888.22 CDW52179.1 - 2.2e-192 641.0 11.9 2.6e-192 640.7 11.9 1.0 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CDW52179.1 - 1.6e-25 88.9 0.1 4.4e-25 87.5 0.1 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain GlnD_UR_UTase PF08335.11 CDW52179.1 - 0.065 13.3 0.4 1.7 8.7 0.1 2.5 2 0 0 2 2 2 0 GlnD PII-uridylyltransferase SYF2 PF08231.12 CDW52180.1 - 8.7e-45 153.0 9.2 8.7e-45 153.0 9.2 2.0 1 1 1 2 2 2 1 SYF2 splicing factor DUF3523 PF12037.8 CDW52180.1 - 3.8 6.8 17.3 0.87 8.9 14.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3523) MRP_L53 PF10780.9 CDW52181.1 - 5.2e-11 42.6 2.1 7.7e-11 42.0 2.1 1.3 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 EGF_3 PF12947.7 CDW52181.1 - 0.094 12.9 0.7 0.18 12.0 0.7 1.4 1 0 0 1 1 1 0 EGF domain PPP4R2 PF09184.11 CDW52182.1 - 7.5e-35 120.9 1.2 1.1e-34 120.3 1.2 1.3 1 0 0 1 1 1 1 PPP4R2 Amidinotransf PF02274.17 CDW52183.1 - 7.3e-05 22.0 0.1 0.039 13.0 0.1 2.2 1 1 0 1 1 1 1 Amidinotransferase Sigma70_r1_1 PF03979.14 CDW52183.1 - 0.027 14.5 0.3 0.053 13.6 0.3 1.4 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 NmrA PF05368.13 CDW52183.1 - 0.05 13.1 0.1 3.8 7.0 0.0 2.2 1 1 1 2 2 2 0 NmrA-like family DctP PF03480.13 CDW52183.1 - 0.05 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 LytR_C PF13399.6 CDW52183.1 - 0.16 13.0 0.0 0.7 10.9 0.0 1.9 1 1 1 2 2 2 0 LytR cell envelope-related transcriptional attenuator Ras PF00071.22 CDW52184.1 - 9.5e-52 174.9 0.0 7.7e-50 168.7 0.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CDW52184.1 - 3.5e-20 72.4 0.0 2.1e-18 66.7 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52184.1 - 6.9e-05 22.4 0.0 0.032 13.7 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW52184.1 - 0.0034 16.9 0.0 0.014 15.0 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Neur_chan_LBD PF02931.23 CDW52185.1 - 6.1e-70 235.0 4.4 8.3e-70 234.6 4.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW52185.1 - 9.3e-47 160.1 9.9 4.6e-45 154.5 9.9 2.1 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region adh_short PF00106.25 CDW52186.1 - 9e-27 93.8 0.0 7.4e-22 77.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDW52186.1 - 1e-14 54.7 0.0 2.6e-14 53.3 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase WW PF00397.26 CDW52186.1 - 2.5e-12 46.7 0.1 1.3e-08 34.8 0.1 2.4 2 0 0 2 2 2 2 WW domain KR PF08659.10 CDW52186.1 - 5.8e-07 29.6 0.0 9.2e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CDW52186.1 - 0.012 14.8 0.1 0.14 11.3 0.1 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 CDW52186.1 - 0.14 11.6 0.0 0.3 10.5 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family SGP PF17228.2 CDW52187.1 - 0.029 15.2 8.0 0.04 14.8 8.0 1.3 1 0 0 1 1 1 0 Sulphur globule protein Ly-6_related PF06579.12 CDW52188.1 - 5.4e-30 104.2 8.3 7.8e-30 103.7 8.3 1.2 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein QVR PF17064.5 CDW52188.1 - 2.1 8.7 15.4 2.6e+03 -1.3 15.4 2.8 1 1 0 1 1 1 0 Sleepless protein TPR_12 PF13424.6 CDW52189.1 - 2.6e-14 53.2 2.6 2e-06 28.0 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDW52189.1 - 1e-08 34.6 9.1 0.056 13.6 0.6 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW52189.1 - 6e-07 29.8 0.5 0.025 15.4 0.0 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDW52189.1 - 2.2e-05 24.1 5.8 0.032 14.1 0.3 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDW52189.1 - 5.7e-05 22.8 7.7 1.3 9.0 0.3 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52189.1 - 7.1e-05 22.7 7.2 0.009 16.2 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat FAT PF02259.23 CDW52189.1 - 0.00015 21.1 0.5 0.037 13.3 0.2 2.2 1 1 1 2 2 2 2 FAT domain TPR_MalT PF17874.1 CDW52189.1 - 0.00024 20.6 0.1 0.012 15.0 0.0 2.2 2 0 0 2 2 2 1 MalT-like TPR region ANAPC5 PF12862.7 CDW52189.1 - 0.0039 17.2 0.5 0.8 9.8 0.0 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_19 PF14559.6 CDW52189.1 - 0.0048 17.4 3.6 2.7 8.6 0.1 3.3 2 1 2 4 4 4 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDW52189.1 - 0.0083 16.1 0.8 0.1 12.5 0.6 2.6 2 1 0 2 2 2 1 Mad3/BUB1 homology region 1 TPR_4 PF07721.14 CDW52189.1 - 0.01 16.4 0.0 0.12 13.1 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat PLC-beta_C PF08703.10 CDW52189.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 PLC-beta C terminal TPR_6 PF13174.6 CDW52189.1 - 0.26 12.0 3.4 20 6.1 0.1 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52189.1 - 0.29 11.3 4.3 15 5.9 0.1 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDW52189.1 - 0.32 11.5 2.2 11 6.7 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat 2-oxoacid_dh PF00198.23 CDW52190.1 - 7.8e-81 270.9 0.0 9.6e-81 270.6 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDW52190.1 - 3.1e-17 62.2 1.2 8e-17 60.8 1.2 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CDW52190.1 - 1.6e-12 47.5 0.1 3.3e-12 46.5 0.1 1.6 1 0 0 1 1 1 1 e3 binding domain HTH_Tnp_Tc5 PF03221.16 CDW52190.1 - 0.043 13.9 0.0 4.7 7.3 0.0 2.4 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain DUF2481 PF10654.9 CDW52190.1 - 0.084 12.9 0.5 0.15 12.0 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) zf-LITAF-like PF10601.9 CDW52191.1 - 4.4e-23 81.3 10.7 6.6e-23 80.8 10.7 1.3 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-ribbon_3 PF13248.6 CDW52191.1 - 8.4e-05 21.8 1.4 0.14 11.7 0.1 2.4 2 0 0 2 2 2 2 zinc-ribbon domain zf-ACC PF17848.1 CDW52191.1 - 0.039 14.0 1.5 1.7 8.8 0.1 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zinc_ribbon_4 PF13717.6 CDW52191.1 - 0.24 11.3 5.7 1.5 8.8 0.0 2.7 3 0 0 3 3 3 0 zinc-ribbon domain Sgf11 PF08209.11 CDW52191.1 - 0.28 10.8 5.7 4.2 7.0 0.1 2.6 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) DZR PF12773.7 CDW52191.1 - 0.41 10.7 6.7 5.3 7.1 6.7 2.3 1 1 0 1 1 1 0 Double zinc ribbon Cpn60_TCP1 PF00118.24 CDW52192.1 - 7.2e-143 476.8 4.7 8.7e-88 295.1 0.1 2.0 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family ArfGap PF01412.18 CDW52193.1 - 2.1e-18 66.5 0.3 2.5e-18 66.2 0.3 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pkinase PF00069.25 CDW52194.1 - 1.2e-70 238.0 0.0 1.5e-70 237.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52194.1 - 4.1e-35 121.3 0.0 6.7e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW52194.1 - 0.025 13.9 0.0 0.1 11.9 0.0 1.8 1 1 1 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 CDW52194.1 - 0.2 10.5 1.6 0.29 10.0 0.0 2.0 2 1 0 2 2 2 0 Haspin like kinase domain LIM PF00412.22 CDW52195.1 - 1.1e-24 86.4 21.4 2.4e-12 46.9 9.9 2.9 3 0 0 3 3 3 2 LIM domain Homeodomain PF00046.29 CDW52195.1 - 1.1e-17 63.7 2.7 1.1e-17 63.7 2.7 2.1 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW52195.1 - 0.00014 21.7 1.1 0.00014 21.7 1.1 2.6 2 1 0 2 2 2 1 Homeobox KN domain Glutaredoxin PF00462.24 CDW52196.1 - 7.4e-18 64.5 0.0 2.4e-17 62.9 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 CDW52196.1 - 5.2e-05 23.2 0.0 9.5e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 CDW52196.1 - 0.0017 18.3 0.0 0.033 14.2 0.0 2.3 2 1 0 2 2 2 1 Hydrogenase-1 expression protein HyaE TrbC_Ftype PF09673.10 CDW52196.1 - 0.0098 15.9 0.0 0.058 13.5 0.0 2.0 2 0 0 2 2 2 1 Type-F conjugative transfer system pilin assembly protein Thioredoxin_2 PF13098.6 CDW52196.1 - 0.014 15.8 0.0 0.031 14.7 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain SH3BGR PF04908.15 CDW52196.1 - 0.038 14.1 0.0 0.081 13.1 0.0 1.6 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein RdRP PF05183.12 CDW52196.1 - 0.11 11.2 0.0 0.13 10.8 0.0 1.3 1 0 0 1 1 1 0 RNA dependent RNA polymerase OST3_OST6 PF04756.13 CDW52196.1 - 0.15 11.4 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family RRM_1 PF00076.22 CDW52197.1 - 2e-18 66.0 0.0 1.9e-17 62.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW52197.1 - 0.00022 21.3 0.0 0.00058 19.9 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CDW52197.1 - 0.008 16.2 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF1314 PF07013.11 CDW52197.1 - 0.013 15.3 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) RRM_5 PF13893.6 CDW52197.1 - 0.042 13.4 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRN3 PF05327.11 CDW52198.1 - 1e-77 262.0 12.1 1e-77 262.0 12.1 2.9 2 1 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 ABC_trans_CmpB PF06541.11 CDW52199.1 - 1.1e-06 29.0 8.4 1.3e-06 28.7 8.4 1.1 1 0 0 1 1 1 1 Putative ABC-transporter type IV Cyclin_N PF00134.23 CDW52200.1 - 3.5e-10 39.7 0.3 1.2e-09 37.9 0.1 2.0 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDW52200.1 - 0.00013 22.1 0.0 0.00055 20.0 0.0 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 CDW52200.1 - 0.16 12.4 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Cyclin C-terminal domain His_Phos_2 PF00328.22 CDW52201.1 - 1.5e-24 87.1 0.8 1.5e-22 80.5 0.8 2.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) SAM_1 PF00536.30 CDW52202.1 - 0.00021 21.7 0.1 0.00043 20.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW52202.1 - 0.094 12.8 0.4 0.57 10.3 0.4 2.1 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Ras PF00071.22 CDW52204.1 - 6.7e-37 126.6 0.0 8.4e-37 126.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52204.1 - 1.6e-17 63.8 0.0 4.4e-17 62.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CDW52204.1 - 5e-07 29.8 0.0 7.5e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CDW52204.1 - 0.00024 20.6 0.0 0.00033 20.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CDW52204.1 - 0.011 15.2 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TsaE PF02367.17 CDW52204.1 - 0.044 13.8 0.2 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TniB PF05621.11 CDW52204.1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 CDW52204.1 - 0.065 13.1 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 CDW52204.1 - 0.067 13.5 0.1 0.15 12.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDW52204.1 - 0.13 12.2 0.1 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 CDW52204.1 - 0.14 12.5 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain tRNA-synt_2b PF00587.25 CDW52205.1 - 1.6e-36 126.0 0.0 2.7e-36 125.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDW52205.1 - 1.5e-19 69.9 0.3 4.2e-19 68.5 0.3 1.8 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 CDW52205.1 - 8.1e-15 54.6 0.0 1.6e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 CDW52205.1 - 3.9e-13 49.2 0.0 8.3e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF1700 PF08006.11 CDW52206.1 - 0.21 11.1 7.2 0.43 10.1 7.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF4728 PF15860.5 CDW52206.1 - 4.7 8.0 13.0 21 5.9 13.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4728) DUF4233 PF14017.6 CDW52206.1 - 6.6 7.1 20.6 10 6.5 16.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4233) DUF3927 PF13064.6 CDW52207.1 - 0.04 13.9 1.0 0.12 12.4 1.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3927) HOOK PF05622.12 CDW52208.1 - 1.1e-11 43.7 56.1 1.1e-11 43.7 56.1 4.8 1 1 2 3 3 3 1 HOOK protein HALZ PF02183.18 CDW52208.1 - 0.056 13.7 0.3 0.026 14.8 4.1 11.4 10 2 1 11 11 11 0 Homeobox associated leucine zipper NOD2_WH PF17779.1 CDW52208.1 - 0.13 12.6 1.3 2.4 8.5 0.1 3.3 3 0 0 3 3 3 0 NOD2 winged helix domain Adenylsucc_synt PF00709.21 CDW52209.1 - 1e-168 561.6 0.0 1.2e-168 561.4 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase CAP PF00188.26 CDW52210.1 - 0.0015 19.4 3.5 0.0015 19.4 3.5 2.2 3 1 0 3 3 3 1 Cysteine-rich secretory protein family Ald_Xan_dh_C2 PF02738.18 CDW52211.1 - 1.4e-176 588.2 0.0 2e-176 587.7 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 CDW52211.1 - 1.6e-33 115.9 0.0 2.9e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 CDW52211.1 - 5.3e-31 107.2 0.0 1.1e-30 106.2 0.0 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 CDW52211.1 - 2.3e-23 82.3 0.0 5.7e-23 81.1 0.0 1.7 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 CDW52211.1 - 7.5e-19 67.5 0.2 7.5e-19 67.5 0.2 2.1 2 0 0 2 2 2 1 [2Fe-2S] binding domain Carn_acyltransf PF00755.20 CDW52212.1 - 1.2e-123 413.9 0.1 5.3e-76 256.5 0.0 2.1 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase MFS_1 PF07690.16 CDW52212.1 - 1.7e-28 99.6 20.0 1.7e-28 99.6 20.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily 7TM_GPCR_Srsx PF10320.9 CDW52213.1 - 1.3e-10 41.1 15.0 1.3e-10 41.1 15.0 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srab PF10292.9 CDW52213.1 - 7.5e-05 21.8 8.4 0.00013 21.0 8.4 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR receptor class ab chemoreceptor 7tm_1 PF00001.21 CDW52213.1 - 0.022 14.1 14.2 0.029 13.7 13.9 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Gal-bind_lectin PF00337.22 CDW52214.1 - 3.6e-37 126.9 11.4 4.4e-05 23.0 0.1 14.1 15 1 0 15 15 15 8 Galactoside-binding lectin LigD_N PF13298.6 CDW52214.1 - 0.011 16.0 0.6 35 4.7 0.0 4.6 4 0 0 4 4 4 0 DNA polymerase Ligase (LigD) DUF1106 PF06523.11 CDW52214.1 - 0.026 14.5 0.0 8.1 6.6 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1106) RNA_pol_Rpb1_2 PF00623.20 CDW52214.1 - 0.1 12.8 0.0 0.45 10.7 0.0 2.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 2 Gal-bind_lectin PF00337.22 CDW52215.1 - 1.9e-31 108.4 4.2 0.059 12.9 0.0 13.3 14 0 0 14 14 14 10 Galactoside-binding lectin Laminin_G_3 PF13385.6 CDW52215.1 - 0.0044 17.2 1.2 0.45 10.6 0.0 4.2 4 0 0 4 4 4 1 Concanavalin A-like lectin/glucanases superfamily Lipocalin_7 PF14651.6 CDW52215.1 - 0.0063 16.5 0.4 4.1 7.4 0.1 3.8 2 0 0 2 2 2 2 Lipocalin / cytosolic fatty-acid binding protein family 7TM_GPCR_Srsx PF10320.9 CDW52216.1 - 6.9e-09 35.5 17.2 8.1e-09 35.2 16.8 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 CDW52216.1 - 0.018 14.3 17.0 0.028 13.8 17.0 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 CDW52216.1 - 0.02 14.4 16.9 0.089 12.3 16.9 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.9 CDW52216.1 - 0.82 9.2 17.3 3.2 7.3 17.3 2.0 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Caveolin PF01146.17 CDW52217.1 - 2.2e-47 160.3 1.9 3.1e-47 159.9 1.9 1.1 1 0 0 1 1 1 1 Caveolin Uso1_p115_head PF04869.14 CDW52217.1 - 0.13 11.4 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region DUF2207 PF09972.9 CDW52217.1 - 0.25 10.1 1.4 0.35 9.6 1.4 1.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MFS_1 PF07690.16 CDW52218.1 - 2e-51 175.0 20.3 2e-51 175.0 20.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW52218.1 - 4.6e-07 29.1 18.7 9.5e-07 28.0 18.7 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter LacY_symp PF01306.19 CDW52218.1 - 1 8.0 9.9 0.41 9.4 0.1 2.6 3 0 0 3 3 3 0 LacY proton/sugar symporter Atg8 PF02991.16 CDW52219.1 - 3.6e-33 113.8 0.1 4.2e-33 113.6 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CDW52219.1 - 5.8e-05 23.4 0.0 6.7e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 PB1 PF00564.24 CDW52219.1 - 0.086 12.8 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 PB1 domain Peptidase_C58 PF03543.14 CDW52219.1 - 0.098 12.4 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Fic PF02661.18 CDW52220.1 - 4.4e-22 78.8 0.0 1.1e-21 77.6 0.0 1.7 1 0 0 1 1 1 1 Fic/DOC family TPR_16 PF13432.6 CDW52220.1 - 0.045 14.4 0.0 0.14 12.8 0.0 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDW52220.1 - 0.071 13.3 0.1 0.22 11.7 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Sdh_cyt PF01127.22 CDW52221.1 - 7.7e-21 74.4 5.6 1e-20 73.9 5.6 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit AraC_N PF06719.13 CDW52221.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 AraC-type transcriptional regulator N-terminus RNA_pol_A_bac PF01000.26 CDW52222.1 - 1.5e-32 112.3 0.0 2.5e-32 111.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CDW52222.1 - 7.1e-18 63.8 0.0 9e-18 63.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PTB PF08416.13 CDW52223.1 - 5.4e-18 65.4 0.2 4.6e-17 62.4 0.0 2.5 3 0 0 3 3 3 1 Phosphotyrosine-binding domain SAM_3 PF18016.1 CDW52223.1 - 2.6e-14 52.8 0.1 1.6e-08 34.2 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 CDW52223.1 - 0.043 13.8 0.1 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain Exonuc_VII_L PF02601.15 CDW52223.1 - 0.081 12.5 0.8 0.52 9.8 0.1 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit SKA1 PF07160.12 CDW52223.1 - 0.21 11.4 4.6 0.19 11.6 0.2 2.6 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 1 F-actin_cap_A PF01267.17 CDW52224.1 - 5e-79 265.5 0.1 6.1e-79 265.2 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit F_actin_cap_B PF01115.17 CDW52224.1 - 0.008 15.8 0.2 0.0099 15.5 0.2 1.2 1 0 0 1 1 1 1 F-actin capping protein, beta subunit PWWP PF00855.17 CDW52225.1 - 0.00033 21.0 0.0 0.0004 20.7 0.0 1.1 1 0 0 1 1 1 1 PWWP domain zf-HC5HC2H_2 PF13832.6 CDW52226.1 - 1.6e-31 108.7 8.0 1.6e-31 108.7 8.0 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CDW52226.1 - 1.2e-22 80.0 3.3 1.2e-22 80.0 3.3 3.2 4 0 0 4 4 4 1 PHD-like zinc-binding domain Bromodomain PF00439.25 CDW52226.1 - 4.6e-18 65.1 0.1 3.3e-17 62.3 0.0 2.4 2 0 0 2 2 2 1 Bromodomain EPL1 PF10513.9 CDW52226.1 - 1.2e-15 58.2 0.2 4.3e-15 56.5 0.0 2.0 2 0 0 2 2 2 1 Enhancer of polycomb-like PHD_2 PF13831.6 CDW52226.1 - 9.2e-15 53.9 3.0 9.2e-15 53.9 3.0 3.0 2 1 1 3 3 3 1 PHD-finger PHD PF00628.29 CDW52226.1 - 3e-07 30.2 12.1 3e-07 30.2 12.1 3.2 3 0 0 3 3 3 2 PHD-finger DUF908 PF06012.12 CDW52226.1 - 0.017 14.6 2.0 0.03 13.8 2.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) C1_2 PF03107.16 CDW52226.1 - 3.8 7.9 19.0 6.5 7.2 6.5 3.0 2 0 0 2 2 2 0 C1 domain zf-C2H2 PF00096.26 CDW52226.1 - 6 7.5 7.0 0.38 11.3 0.2 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Dynactin_p62 PF05502.13 CDW52227.1 - 1.4e-16 60.4 16.1 3.6e-08 32.6 0.2 3.2 3 0 0 3 3 3 3 Dynactin p62 family RRM_1 PF00076.22 CDW52228.1 - 6.3e-12 45.1 0.0 9.7e-12 44.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CDW52228.1 - 1.1e-06 28.4 1.8 3.1e-06 27.1 1.8 1.8 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 CDW52228.1 - 5e-06 27.2 0.0 1e-05 26.2 0.0 1.5 1 0 0 1 1 1 1 Torus domain RRM_occluded PF16842.5 CDW52228.1 - 0.0011 18.7 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif zf-CCCH PF00642.24 CDW52228.1 - 0.0016 18.3 1.2 0.0016 18.3 1.2 2.8 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nup35_RRM_2 PF14605.6 CDW52228.1 - 0.0019 18.1 0.1 0.0038 17.2 0.1 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-CCCH_2 PF14608.6 CDW52228.1 - 0.0043 17.5 0.5 0.013 16.0 0.5 1.9 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CDW52228.1 - 0.0068 16.2 1.8 0.014 15.1 1.8 1.6 1 0 0 1 1 1 1 CCCH-type zinc finger RRM_3 PF08777.11 CDW52228.1 - 0.012 15.7 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Limkain-b1 PF11608.8 CDW52228.1 - 0.028 14.5 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 zinc-ribbons_6 PF07191.12 CDW52228.1 - 2.4 8.2 8.5 6.4 6.8 8.5 1.8 1 0 0 1 1 1 0 zinc-ribbons Mob1_phocein PF03637.17 CDW52229.1 - 1.1e-75 253.3 0.1 1.5e-75 252.9 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family Metallophos PF00149.28 CDW52230.1 - 4e-35 122.2 0.4 7.1e-35 121.4 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW52230.1 - 0.0015 18.9 0.2 0.0035 17.7 0.2 1.7 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 CDW52230.1 - 0.012 15.3 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain DUF5378 PF17349.2 CDW52230.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Ribosomal_L44 PF00935.19 CDW52231.1 - 1.1e-34 118.7 17.2 1.6e-34 118.2 17.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Tetraspanin PF00335.20 CDW52232.1 - 1.3e-49 169.0 9.2 3.5e-45 154.5 3.1 2.0 1 1 1 2 2 2 2 Tetraspanin family tRNA-synt_1c PF00749.21 CDW52233.1 - 2.7e-90 302.4 0.0 3.5e-90 302.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Imm-NTF2 PF15655.6 CDW52233.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 NTF2 fold immunity protein Torus PF16131.5 CDW52234.1 - 9.5e-06 26.3 1.2 1.6e-05 25.5 1.0 1.5 1 1 1 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 CDW52234.1 - 1e-05 25.4 3.6 1e-05 25.4 3.6 1.6 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 CDW52234.1 - 2e-05 24.4 3.1 3.5e-05 23.6 3.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDW52234.1 - 0.008 16.0 1.4 0.008 16.0 1.4 2.2 2 0 0 2 2 2 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDW52234.1 - 0.0091 16.4 1.9 0.015 15.8 1.9 1.4 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger RUN PF02759.19 CDW52235.1 - 3e-19 69.3 0.0 1.9e-18 66.7 0.0 2.4 1 1 0 1 1 1 1 RUN domain FYVE_2 PF02318.16 CDW52235.1 - 0.51 10.6 0.0 0.51 10.6 0.0 3.1 4 0 0 4 4 4 0 FYVE-type zinc finger Mut7-C PF01927.16 CDW52235.1 - 1.1 9.4 5.1 8.9 6.4 0.2 3.0 2 1 1 3 3 3 0 Mut7-C RNAse domain PDZ PF00595.24 CDW52236.1 - 4.9e-23 81.3 0.0 6.8e-12 45.6 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 CDW52236.1 - 9.7e-21 73.4 0.5 3.9e-11 42.6 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 CDW52236.1 - 3.9e-13 49.5 0.1 2.5e-06 27.7 0.0 2.5 2 1 0 2 2 2 2 PDZ domain DUF3394 PF11874.8 CDW52236.1 - 0.0011 18.7 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3394) GRASP55_65 PF04495.14 CDW52236.1 - 0.0039 17.5 0.0 0.62 10.4 0.0 2.2 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain Tricorn_PDZ PF14685.6 CDW52236.1 - 0.0066 16.4 0.1 0.92 9.5 0.0 2.4 2 0 0 2 2 2 1 Tricorn protease PDZ domain Pkinase PF00069.25 CDW52238.1 - 2e-68 230.6 0.0 2.6e-68 230.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52238.1 - 3.9e-35 121.4 0.0 5.2e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW52238.1 - 2.2e-05 23.6 0.0 9.7e-05 21.5 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW52238.1 - 2.4e-05 23.8 0.0 3.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDW52238.1 - 0.00077 18.9 0.1 0.00077 18.9 0.1 1.9 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW52238.1 - 0.013 15.4 0.0 0.04 13.8 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CDW52238.1 - 0.13 11.3 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 NTF2 PF02136.20 CDW52239.1 - 1e-26 93.9 0.0 1.1e-26 93.7 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 CDW52239.1 - 0.046 14.1 0.0 0.06 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Pkinase PF00069.25 CDW52240.1 - 1.9e-26 93.0 0.1 3e-26 92.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52240.1 - 1.5e-13 50.6 0.2 4.3e-13 49.1 0.2 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW52240.1 - 6.7e-11 41.6 0.2 1.1e-10 40.9 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase EcKinase PF02958.20 CDW52240.1 - 0.0028 17.0 0.0 0.004 16.5 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 CDW52240.1 - 0.016 15.2 0.0 0.14 12.1 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CDW52240.1 - 0.017 14.5 1.5 0.019 14.4 0.1 1.8 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family TDP43_N PF18694.1 CDW52240.1 - 0.13 12.1 0.1 7.8 6.4 0.0 3.0 3 0 0 3 3 3 0 Transactive response DNA-binding protein N-terminal domain Arrestin_C PF02752.22 CDW52242.1 - 7.7e-15 55.5 0.1 9.1e-12 45.6 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CDW52242.1 - 7.8e-13 48.7 0.5 4.8e-10 39.7 0.1 3.5 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 CDW52242.1 - 0.0014 18.3 0.0 0.0055 16.3 0.0 1.8 2 0 0 2 2 2 1 SpoOM protein Methyltransf_21 PF05050.12 CDW52243.1 - 1.7e-08 34.7 0.0 3.1e-07 30.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase FkbM domain Op_neuropeptide PF08035.11 CDW52243.1 - 0.028 14.3 0.1 0.051 13.4 0.1 1.4 1 0 0 1 1 1 0 Opioids neuropeptide MIF4G PF02854.19 CDW52244.1 - 1.1e-41 142.8 8.6 1.1e-18 67.7 0.0 3.3 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.14 CDW52244.1 - 6.9e-10 39.8 14.4 0.00014 22.6 0.2 3.8 3 0 0 3 3 3 2 Up-frameshift suppressor 2 QIL1 PF15884.5 CDW52244.1 - 0.11 13.1 0.0 0.67 10.6 0.0 2.4 1 0 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 ATP_bind_1 PF03029.17 CDW52245.1 - 6.8e-81 271.6 0.0 7.7e-81 271.4 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 CDW52245.1 - 0.0003 21.3 0.0 0.00072 20.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain CLP1_P PF16575.5 CDW52245.1 - 0.00039 20.3 0.0 0.00087 19.1 0.0 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 CDW52245.1 - 0.012 15.9 0.1 0.087 13.1 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CDW52245.1 - 0.044 14.2 0.1 0.37 11.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDW52245.1 - 0.049 13.3 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDW52245.1 - 0.072 13.5 0.0 0.86 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_10 PF12846.7 CDW52245.1 - 0.08 11.9 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_24 PF13479.6 CDW52245.1 - 0.087 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 CDW52245.1 - 0.092 12.5 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_29 PF13555.6 CDW52245.1 - 0.12 12.1 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 CDW52245.1 - 0.13 12.7 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 CDW52245.1 - 0.15 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Trypsin PF00089.26 CDW52246.1 - 5.1e-16 59.1 0.0 3.5e-07 30.3 0.0 2.2 2 0 0 2 2 2 2 Trypsin Kazal_1 PF00050.21 CDW52247.1 - 4e-14 52.4 1.1 7.2e-14 51.5 1.1 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 CDW52247.1 - 8.2e-09 35.5 1.0 1.4e-08 34.7 1.0 1.4 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Statherin PF03875.13 CDW52247.1 - 0.011 15.9 0.1 0.02 15.0 0.1 1.4 1 0 0 1 1 1 0 Statherin BTB_2 PF02214.22 CDW52249.1 - 3.7e-19 68.9 0.2 8.7e-19 67.7 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain TnpW PF14202.6 CDW52249.1 - 0.099 12.5 2.0 8 6.4 0.4 2.4 2 0 0 2 2 2 0 Transposon-encoded protein TnpW BTB_3 PF16017.5 CDW52249.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain DNA_pol_E_B PF04042.16 CDW52250.1 - 6.3e-44 149.9 0.7 9.4e-44 149.3 0.7 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B BLOC1_2 PF10046.9 CDW52250.1 - 6.7e-20 71.2 3.6 1.4e-19 70.1 3.6 1.5 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Dpoe2NT PF12213.8 CDW52250.1 - 1.1e-09 38.4 0.0 3.7e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal BOF PF04076.13 CDW52250.1 - 0.0021 18.1 0.0 0.005 16.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial OB fold (BOF) protein Baculo_gp41 PF04700.12 CDW52250.1 - 0.0043 16.8 0.4 0.056 13.2 0.3 2.4 3 0 0 3 3 3 1 Structural glycoprotein p40/gp41 conserved region Tape_meas_lam_C PF09718.10 CDW52250.1 - 0.077 13.1 0.0 0.27 11.4 0.0 1.9 1 0 0 1 1 1 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) MRP-L46 PF11788.8 CDW52251.1 - 3.2e-12 47.2 0.9 4.5e-12 46.7 0.9 1.2 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 Prp18 PF02840.15 CDW52252.1 - 1e-45 155.3 2.1 5.5e-44 149.7 0.5 3.0 2 1 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 CDW52252.1 - 3e-10 39.4 3.2 5.8e-10 38.6 3.2 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like DSPc PF00782.20 CDW52253.1 - 2.6e-41 140.6 0.0 3.7e-41 140.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 CDW52253.1 - 2.7e-06 27.9 0.0 8.9e-06 26.2 0.0 1.9 2 0 0 2 2 2 1 Rhodanese-like domain Y_phosphatase PF00102.27 CDW52253.1 - 0.00077 19.1 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 CDW52253.1 - 0.0063 16.8 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 CDW52253.1 - 0.028 14.5 0.0 0.05 13.7 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate MWFE PF15879.5 CDW52254.1 - 0.012 15.8 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase MWFE subunit Herpes_gE PF02480.16 CDW52254.1 - 0.014 14.1 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Epiglycanin_C PF14654.6 CDW52254.1 - 0.021 14.9 0.2 0.052 13.6 0.1 1.7 2 0 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region Peptidase_C1 PF00112.23 CDW52255.1 - 4e-117 390.0 11.7 4.1e-59 200.3 1.3 2.7 3 0 0 3 3 3 2 Papain family cysteine protease CathepsinC_exc PF08773.11 CDW52255.1 - 9e-38 129.3 2.0 1.7e-37 128.4 2.0 1.5 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 CDW52255.1 - 1.7e-09 37.0 8.9 5.5e-06 25.4 0.5 3.4 4 0 0 4 4 4 2 Peptidase C1-like family Propeptide_C1 PF08127.13 CDW52255.1 - 3.5e-07 30.0 0.2 0.0032 17.3 0.0 2.7 2 0 0 2 2 2 2 Peptidase family C1 propeptide Ion_trans PF00520.31 CDW52256.1 - 1.4e-33 116.2 11.7 1.9e-33 115.7 11.7 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 CDW52256.1 - 2.3e-13 50.0 0.0 4.8e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 CDW52256.1 - 3.3e-10 39.8 3.8 3.3e-10 39.8 3.8 2.9 4 0 0 4 4 4 1 Ion channel IRK PF01007.20 CDW52256.1 - 0.65 9.8 7.6 4.5 7.1 7.6 2.3 1 1 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain OppC_N PF12911.7 CDW52256.1 - 5.9 6.9 6.7 21 5.2 1.9 2.8 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DEAD PF00270.29 CDW52257.1 - 4.8e-50 169.7 0.0 1.7e-49 168.0 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW52257.1 - 1.1e-27 96.6 0.0 4.5e-27 94.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW52257.1 - 0.026 14.5 0.0 0.074 13.0 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit HEM4 PF02602.15 CDW52257.1 - 0.081 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD CMS1 PF14617.6 CDW52257.1 - 0.19 11.0 0.0 0.19 11.0 0.0 2.9 3 0 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit Thioredoxin_8 PF13905.6 CDW52258.1 - 1.1e-21 77.0 0.6 1.5e-21 76.5 0.6 1.2 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CDW52258.1 - 1.4e-09 37.8 0.1 1.9e-09 37.4 0.1 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDW52258.1 - 4.7e-09 36.2 0.2 6.8e-09 35.7 0.2 1.3 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 CDW52258.1 - 1.5e-06 28.7 0.1 2.2e-06 28.1 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.20 CDW52258.1 - 4e-06 26.8 1.3 0.00015 21.7 0.4 2.1 1 1 1 2 2 2 1 Thioredoxin TraF PF13728.6 CDW52258.1 - 0.00043 20.2 0.5 0.0012 18.8 0.4 1.6 1 1 0 1 1 1 1 F plasmid transfer operon protein SCO1-SenC PF02630.14 CDW52258.1 - 0.0034 17.3 0.0 0.0049 16.8 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC ANF_receptor PF01094.28 CDW52258.1 - 0.016 14.4 0.9 0.039 13.0 0.1 1.8 1 1 1 2 2 2 0 Receptor family ligand binding region Thioredoxin_7 PF13899.6 CDW52258.1 - 0.022 14.9 0.9 0.075 13.2 0.9 2.0 1 1 0 1 1 1 0 Thioredoxin-like DUF836 PF05768.14 CDW52258.1 - 0.026 14.9 0.5 0.072 13.5 0.5 1.7 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 CDW52258.1 - 0.034 14.4 0.4 0.27 11.5 0.3 2.1 1 1 1 2 2 2 0 Glutaredoxin ApoC-I PF04691.12 CDW52258.1 - 0.089 12.7 1.8 11 6.0 0.0 2.8 3 0 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) Ribosomal_L22e PF01776.17 CDW52259.1 - 9.2e-47 157.9 0.1 1.2e-46 157.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family WD40 PF00400.32 CDW52260.1 - 1.4e-49 165.0 32.7 6.3e-08 33.2 0.1 10.7 10 0 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52260.1 - 2.3e-16 59.9 0.0 0.027 14.7 0.0 6.7 3 3 1 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 CDW52260.1 - 6.7e-12 45.7 0.9 1.3e-11 44.8 0.9 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 CDW52260.1 - 1.2e-11 44.2 9.6 0.0036 16.3 0.0 7.7 2 2 5 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDW52260.1 - 6.7e-10 38.8 2.4 0.0015 17.9 0.0 5.2 3 3 2 5 5 5 3 WD40-like domain BBS2_Mid PF14783.6 CDW52260.1 - 0.0019 18.2 0.1 0.68 10.0 0.0 4.1 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region PALB2_WD40 PF16756.5 CDW52260.1 - 0.0096 14.9 3.9 0.082 11.8 0.2 3.0 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 CDW52260.1 - 0.061 12.0 1.2 1.2 7.7 0.0 3.0 3 1 0 3 3 3 0 Nucleoporin Nup120/160 PD40 PF07676.12 CDW52260.1 - 0.47 10.5 1.3 2.5 8.1 0.1 2.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat HMG_box PF00505.19 CDW52261.1 - 1.5e-08 34.9 0.1 3.4e-08 33.8 0.1 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box TPR_2 PF07719.17 CDW52262.1 - 4.9e-18 63.7 9.2 0.15 12.3 0.1 9.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDW52262.1 - 2.6e-14 52.3 7.9 0.15 11.9 0.3 8.8 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDW52262.1 - 2.3e-12 47.2 9.3 0.0016 18.9 0.1 6.8 4 2 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDW52262.1 - 1.6e-11 44.0 19.4 0.023 15.5 0.1 8.6 6 2 3 9 9 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52262.1 - 1.5e-10 40.4 2.2 0.34 11.2 0.2 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW52262.1 - 2.1e-10 41.1 4.2 0.18 12.5 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDW52262.1 - 4.9e-08 33.1 17.6 0.027 14.8 1.4 7.5 6 2 3 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW52262.1 - 9e-08 32.2 24.8 0.0025 18.0 1.9 6.5 5 3 2 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CDW52262.1 - 4.8e-06 26.2 16.3 0.57 10.3 0.1 8.8 9 1 0 9 9 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW52262.1 - 0.00013 22.1 8.2 7.1 7.3 0.1 7.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW52262.1 - 0.00042 19.8 7.8 2.7 7.3 0.0 4.5 4 0 0 4 4 4 1 MalT-like TPR region TPR_10 PF13374.6 CDW52262.1 - 0.00053 19.8 5.9 1.8 8.5 0.1 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDW52262.1 - 0.00061 19.9 6.7 0.04 14.1 0.0 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW52262.1 - 0.0045 16.6 1.7 16 5.2 0.0 5.3 5 0 0 5 5 5 0 TPR repeat TPR_6 PF13174.6 CDW52262.1 - 0.026 15.1 2.4 2.5e+02 2.6 0.0 5.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDW52262.1 - 0.063 13.0 5.1 0.41 10.3 0.1 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain S100PBPR PF15427.6 CDW52262.1 - 0.45 9.7 3.1 0.78 8.9 3.1 1.3 1 0 0 1 1 1 0 S100P-binding protein Ribosomal_60s PF00428.19 CDW52264.1 - 2.3e-11 44.1 8.7 2.7e-06 27.8 0.1 2.1 1 1 1 2 2 2 2 60s Acidic ribosomal protein Ion_trans_2 PF07885.16 CDW52265.1 - 5.6e-34 116.0 22.4 8.1e-19 67.4 9.8 3.1 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CDW52265.1 - 1.6e-06 27.5 4.3 0.00011 21.5 0.1 2.3 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 CDW52265.1 - 0.0065 16.3 2.6 0.55 10.0 0.8 2.7 2 0 0 2 2 2 2 Inward rectifier potassium channel transmembrane domain DUF3392 PF11872.8 CDW52265.1 - 0.23 11.7 11.0 2.1 8.7 3.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3392) Ion_trans_2 PF07885.16 CDW52266.1 - 1.4e-32 111.5 20.3 1.2e-17 63.6 2.7 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 CDW52266.1 - 1.1e-06 28.1 10.3 0.00011 21.6 2.8 2.2 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 CDW52266.1 - 0.00086 19.1 4.3 0.057 13.2 0.7 2.4 2 0 0 2 2 2 2 Inward rectifier potassium channel transmembrane domain TcpE PF12648.7 CDW52266.1 - 1.8 9.1 7.9 0.47 11.0 0.8 2.5 2 0 0 2 2 2 0 TcpE family Actin PF00022.19 CDW52267.1 - 8.3e-19 67.5 0.1 1.5e-18 66.6 0.0 1.4 2 0 0 2 2 2 1 Actin Pkinase PF00069.25 CDW52268.1 - 2.8e-14 53.1 0.0 3.4e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52268.1 - 4.1e-11 42.7 0.0 5.3e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW52268.1 - 0.15 11.3 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like BTB PF00651.31 CDW52269.1 - 8.8e-28 96.8 0.1 1.8e-27 95.7 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 CDW52269.1 - 1.7e-22 79.5 0.9 3.1e-22 78.6 0.9 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_1 PF01344.25 CDW52269.1 - 3.8e-18 64.8 0.2 6.1e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 CDW52269.1 - 6.7e-06 26.2 0.2 0.06 13.6 0.0 3.0 2 1 1 3 3 3 2 Kelch motif Kelch_2 PF07646.15 CDW52269.1 - 3e-05 23.8 0.0 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 1 Kelch motif CBF PF03914.17 CDW52269.1 - 0.0003 20.9 0.0 0.00049 20.2 0.0 1.3 1 0 0 1 1 1 1 CBF/Mak21 family Kelch_4 PF13418.6 CDW52269.1 - 0.035 14.1 0.0 0.73 9.9 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_3 PF13415.6 CDW52269.1 - 0.039 14.2 0.2 14 6.1 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF3342 PF11822.8 CDW52269.1 - 0.098 12.9 0.2 0.28 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) Motile_Sperm PF00635.26 CDW52270.1 - 1.3e-12 47.5 0.0 1.6e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CHDNT PF08073.12 CDW52271.1 - 0.17 11.9 0.2 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 CHDNT (NUC034) domain PNRC PF15365.6 CDW52272.1 - 0.069 13.0 2.1 0.095 12.5 2.1 1.2 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif RRM_1 PF00076.22 CDW52273.1 - 2.4e-33 113.7 0.2 5.5e-16 58.1 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW52273.1 - 2.9e-10 40.1 0.4 0.00081 19.5 0.0 2.9 2 2 0 2 2 2 2 RNA recognition motif CSD PF00313.22 CDW52273.1 - 0.0047 16.7 1.0 0.84 9.5 0.3 2.4 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain Nup35_RRM_2 PF14605.6 CDW52273.1 - 0.045 13.8 0.2 10 6.2 0.0 2.8 2 1 1 3 3 3 0 Nup53/35/40-type RNA recognition motif NID PF07292.13 CDW52273.1 - 0.065 13.9 0.3 3 8.5 0.1 2.3 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) Asp_protease PF09668.10 CDW52274.1 - 5.1e-51 171.6 1.5 1.1e-50 170.6 1.5 1.6 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW52274.1 - 3e-22 79.0 0.0 9.2e-22 77.4 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW52274.1 - 7.6e-09 36.1 0.0 2e-08 34.7 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDW52274.1 - 9.5e-05 22.7 0.0 0.00022 21.4 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 CDW52274.1 - 0.00011 21.9 1.9 0.00016 21.4 0.2 2.2 2 1 0 2 2 2 1 Retroviral aspartyl protease ubiquitin PF00240.23 CDW52274.1 - 0.039 13.7 0.0 0.09 12.5 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin family Rad60-SLD_2 PF13881.6 CDW52274.1 - 0.042 13.9 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CDW52274.1 - 0.055 13.5 0.0 1.4 9.0 0.0 2.6 2 0 0 2 2 2 0 Ubiquitin-like domain UBA PF00627.31 CDW52274.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain GDI PF00996.18 CDW52275.1 - 0.057 11.9 0.0 0.096 11.2 0.0 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor VAPB_antitox PF02697.14 CDW52275.1 - 1.4 9.7 6.6 0.3 11.9 1.1 2.4 3 0 0 3 3 3 0 Putative antitoxin fn3 PF00041.21 CDW52276.1 - 7.6e-268 865.8 134.4 5.9e-17 61.8 0.5 38.3 37 2 0 37 37 37 31 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 CDW52276.1 - 4.9e-45 152.0 65.4 0.0024 18.4 0.2 27.7 28 2 0 28 28 28 12 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 CDW52276.1 - 2.2e-14 53.7 0.4 2 8.8 0.0 14.1 17 0 0 17 17 16 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 CDW52276.1 - 2.2e-07 31.2 7.8 0.41 11.1 0.0 11.2 13 0 0 13 13 13 1 Uncharacterised conserved protein (DUF2369) Glyco_hydro_36C PF16874.5 CDW52276.1 - 1.5e-06 28.6 0.0 16 6.1 0.0 8.7 10 0 0 10 10 8 0 Glycosyl hydrolase family 36 C-terminal domain fn3_2 PF16893.5 CDW52276.1 - 3.7e-06 27.0 6.9 5 7.4 0.0 9.2 12 0 0 12 12 9 1 Fibronectin type III domain PhoD_N PF16655.5 CDW52276.1 - 1.3e-05 25.6 11.1 24 5.6 0.0 9.8 10 0 0 10 10 9 0 PhoD-like phosphatase, N-terminal domain fn3_4 PF16794.5 CDW52276.1 - 0.001 18.9 0.2 4.3 7.3 0.0 7.3 10 0 0 10 10 8 1 Fibronectin-III type domain Tissue_fac PF01108.17 CDW52276.1 - 0.0011 18.7 33.0 1.4 8.8 0.1 14.1 15 1 1 16 16 15 1 Tissue factor DUF5581 PF17744.1 CDW52276.1 - 0.027 13.9 0.0 0.41 10.0 0.0 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5581) DUF4381 PF14316.6 CDW52276.1 - 0.11 12.7 3.5 0.22 11.8 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) YebF PF13995.6 CDW52276.1 - 0.17 11.9 0.8 6.1 6.9 0.1 3.3 3 0 0 3 3 3 0 YebF-like protein TssO PF17561.2 CDW52276.1 - 0.22 11.6 0.0 0.53 10.4 0.0 1.6 1 0 0 1 1 1 0 Type VI secretion system, TssO Arylsulfotran_N PF17425.2 CDW52276.1 - 0.87 9.7 17.0 15 5.7 0.0 8.8 10 0 0 10 10 9 0 Arylsulfotransferase Ig-like domain Ion_trans PF00520.31 CDW52278.1 - 2.8e-28 98.8 18.8 5e-28 98.0 18.8 1.4 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 CDW52278.1 - 5.9e-28 96.9 1.4 1.5e-27 95.6 1.4 1.8 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 CDW52278.1 - 8.9e-10 39.0 0.2 6e-07 30.0 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW52278.1 - 7e-09 35.2 0.4 0.66 10.7 0.0 5.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 CDW52278.1 - 2.8e-08 34.1 0.1 0.00017 22.1 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW52278.1 - 0.00036 20.8 0.2 0.24 11.7 0.0 3.2 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Sh_2 PF17512.2 CDW52278.1 - 0.024 14.4 0.3 1.2 8.9 0.2 2.3 2 0 0 2 2 2 0 Metapneumovirus Small hydrophobic protein Ank PF00023.30 CDW52278.1 - 0.031 14.7 0.0 16 6.1 0.0 3.2 2 1 0 2 2 2 0 Ankyrin repeat DUF445 PF04286.12 CDW52278.1 - 1.7 8.4 5.0 3.1 7.5 4.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF445) ATP_synt_H PF05493.13 CDW52278.1 - 1.9 9.0 6.4 0.5 10.9 0.6 2.8 2 0 0 2 2 2 0 ATP synthase subunit H BRCA-2_OB1 PF09103.10 CDW52279.1 - 5.5e-31 107.1 0.0 1.2e-30 106.0 0.0 1.6 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_OB3 PF09104.10 CDW52279.1 - 2.2e-26 92.2 0.0 4.6e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 BRCA-2_helical PF09169.10 CDW52279.1 - 8.4e-10 38.6 0.6 0.00058 19.6 0.0 2.6 2 0 0 2 2 2 2 BRCA2, helical BRCA2 PF00634.18 CDW52279.1 - 0.001 18.7 2.5 0.69 9.6 0.0 3.7 3 0 0 3 3 3 2 BRCA2 repeat POT1 PF02765.17 CDW52279.1 - 0.03 14.2 0.1 0.2 11.5 0.0 2.3 2 0 0 2 2 2 0 Telomeric single stranded DNA binding POT1/CDC13 Mg_trans_NIPA PF05653.14 CDW52280.1 - 4.9e-87 291.8 22.9 5.7e-87 291.6 22.9 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CDW52280.1 - 4.6e-08 33.3 4.1 4.6e-08 33.3 4.1 4.2 2 2 1 3 3 3 2 EamA-like transporter family EMP24_GP25L PF01105.24 CDW52280.1 - 0.11 12.4 0.5 0.27 11.2 0.5 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Wzy_C_2 PF11846.8 CDW52280.1 - 7.3 6.5 7.2 0.33 10.9 0.2 2.2 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal Actin PF00022.19 CDW52281.1 - 2.4e-148 494.1 0.0 6.3e-77 258.9 0.0 2.0 1 1 1 2 2 2 2 Actin Ras PF00071.22 CDW52282.1 - 8.3e-56 188.1 0.4 9.8e-56 187.8 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52282.1 - 6.8e-33 113.4 0.1 9.6e-33 113.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52282.1 - 7.1e-15 54.9 0.2 8.9e-15 54.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW52282.1 - 6.4e-08 32.2 0.1 1.5e-07 31.1 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW52282.1 - 9.7e-06 25.6 0.0 1.8e-05 24.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CDW52282.1 - 5.9e-05 22.6 0.0 8.1e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDW52282.1 - 0.0027 17.3 0.2 0.0074 15.8 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW52282.1 - 0.0067 16.3 0.2 0.19 11.6 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MCM PF00493.23 CDW52282.1 - 0.025 13.7 0.1 0.14 11.2 0.0 1.9 2 0 0 2 2 2 0 MCM P-loop domain AAA_24 PF13479.6 CDW52282.1 - 0.039 13.7 0.1 0.062 13.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDW52282.1 - 0.066 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CDW52282.1 - 0.077 13.4 0.0 0.11 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CDW52282.1 - 0.11 12.0 0.0 0.25 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 CDW52282.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain 7tm_1 PF00001.21 CDW52284.1 - 0.0045 16.3 16.6 0.006 15.9 16.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2070 PF09843.9 CDW52284.1 - 0.22 9.8 9.0 0.34 9.1 9.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SecE PF00584.20 CDW52284.1 - 9.2 6.3 8.4 1.3 9.0 1.8 2.5 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex Ribosomal_60s PF00428.19 CDW52285.1 - 8.3e-21 74.4 5.2 1e-20 74.1 5.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 CDW52285.1 - 0.2 10.1 0.2 0.22 10.0 0.2 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein ShK PF01549.24 CDW52286.1 - 6.4e-05 23.4 8.9 0.0001 22.8 8.9 1.3 1 0 0 1 1 1 1 ShK domain-like PAC4 PF16093.5 CDW52286.1 - 0.15 12.2 0.4 0.29 11.3 0.4 1.4 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 ZZ PF00569.17 CDW52287.1 - 1.2e-10 41.1 4.5 1.9e-10 40.4 4.5 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 CDW52287.1 - 0.0095 16.2 5.2 0.0095 16.2 5.2 2.1 2 0 0 2 2 2 1 C1 domain ELMO_CED12 PF04727.13 CDW52288.1 - 6.4e-41 140.4 0.0 8.8e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 ELMO/CED-12 family BLM_N PF16202.5 CDW52289.1 - 0.015 14.4 2.5 0.024 13.7 2.4 1.4 1 1 0 1 1 1 0 N-terminal region of Bloom syndrome protein FtsH_ext PF06480.15 CDW52289.1 - 1 9.7 8.8 0.15 12.4 2.6 2.8 2 1 0 2 2 2 0 FtsH Extracellular CBM_14 PF01607.24 CDW52290.1 - 6.7e-91 298.4 104.7 1.6e-13 50.6 4.3 10.2 10 0 0 10 10 10 10 Chitin binding Peritrophin-A domain Carb_anhydrase PF00194.21 CDW52291.1 - 3.3e-78 262.7 0.0 3.7e-78 262.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Ion_trans_2 PF07885.16 CDW52292.1 - 5.1e-23 80.8 19.1 9.3e-13 48.0 1.2 2.9 2 1 0 2 2 2 2 Ion channel DUF3592 PF12158.8 CDW52292.1 - 0.061 13.4 1.6 0.18 11.8 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3592) Ldl_recept_a PF00057.18 CDW52293.1 - 4.7e-77 253.9 189.6 3.1e-10 40.1 8.4 13.4 13 0 0 13 13 13 13 Low-density lipoprotein receptor domain class A Trypsin PF00089.26 CDW52294.1 - 2.6e-20 73.2 0.0 3.5e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 Trypsin Ldl_recept_a PF00057.18 CDW52294.1 - 2.9e-05 24.2 7.2 2.9e-05 24.2 7.2 1.8 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A adh_short PF00106.25 CDW52295.1 - 2.8e-38 131.4 0.0 3.8e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW52295.1 - 5.3e-20 72.0 0.0 7.7e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW52295.1 - 1.8e-07 31.2 0.0 2.9e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Glu-tRNAGln PF02686.15 CDW52296.1 - 1.3e-08 35.0 0.0 2.9e-08 33.9 0.0 1.5 2 0 0 2 2 2 1 Glu-tRNAGln amidotransferase C subunit OrfB_Zn_ribbon PF07282.11 CDW52296.1 - 0.089 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain IBR PF01485.21 CDW52297.1 - 4.7e-19 68.4 40.7 1.5e-13 50.7 10.3 4.5 4 1 0 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 CDW52297.1 - 0.0011 18.8 6.7 0.0011 18.8 6.7 4.7 4 1 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW52297.1 - 0.0043 17.0 7.6 0.0043 17.0 7.6 4.5 4 1 0 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.6 CDW52297.1 - 0.019 15.3 8.5 0.019 15.3 8.5 4.4 3 2 0 3 3 3 0 Ring finger domain HMGL-like PF00682.19 CDW52298.1 - 9.2e-46 156.5 0.1 2.2e-45 155.3 0.1 1.5 1 1 0 1 1 1 1 HMGL-like DUF4060 PF13269.6 CDW52298.1 - 0.095 12.8 0.0 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4060) Ribosomal_L5 PF00281.19 CDW52299.1 - 7.1e-22 77.5 0.1 6e-21 74.5 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.21 CDW52299.1 - 1.1e-20 73.6 0.0 1.8e-20 72.9 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus tRNA_anti-like PF12869.7 CDW52299.1 - 0.16 11.6 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 tRNA_anti-like V-ATPase_H_N PF03224.14 CDW52300.1 - 4.2e-97 325.2 2.0 4.2e-97 325.2 2.0 1.7 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 CDW52300.1 - 1.3e-45 154.2 3.9 1.4e-45 154.2 0.2 2.7 3 0 0 3 3 3 1 V-ATPase subunit H HEAT_2 PF13646.6 CDW52300.1 - 4.4e-07 30.2 0.1 0.00057 20.2 0.0 2.9 3 0 0 3 3 3 2 HEAT repeats Arm_2 PF04826.13 CDW52300.1 - 2.8e-05 23.7 0.0 0.00093 18.7 0.0 2.4 2 0 0 2 2 2 1 Armadillo-like Arm PF00514.23 CDW52300.1 - 9.8e-05 22.3 0.8 6.8 6.9 0.0 4.6 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat Transcrip_act PF04949.13 CDW52300.1 - 0.0034 17.3 1.0 0.0078 16.1 1.0 1.5 1 0 0 1 1 1 1 Transcriptional activator Adaptin_N PF01602.20 CDW52300.1 - 0.0034 16.0 1.7 1.6 7.2 0.0 3.1 3 1 1 4 4 4 2 Adaptin N terminal region HEAT PF02985.22 CDW52300.1 - 0.12 12.7 0.0 0.65 10.4 0.0 2.3 1 0 0 1 1 1 0 HEAT repeat HEAT_EZ PF13513.6 CDW52300.1 - 0.15 12.6 0.1 15 6.3 0.0 3.1 3 0 0 3 3 3 0 HEAT-like repeat ApoLp-III PF07464.11 CDW52300.1 - 1.8 8.7 5.8 13 5.9 0.0 2.7 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Fcf1 PF04900.12 CDW52301.1 - 1.9e-22 79.5 0.2 3.8e-22 78.5 0.2 1.5 1 0 0 1 1 1 1 Fcf1 Cation_efflux PF01545.21 CDW52302.1 - 6.1e-45 153.4 24.4 8.6e-45 152.9 24.4 1.2 1 0 0 1 1 1 1 Cation efflux family IncF PF17626.2 CDW52302.1 - 0.11 12.8 0.3 0.11 12.8 0.3 2.2 2 0 0 2 2 2 0 Inclusion membrane protein F EI24 PF07264.11 CDW52302.1 - 0.23 11.7 10.2 0.44 10.8 10.2 1.4 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Filament PF00038.21 CDW52303.1 - 0.011 15.3 4.7 0.019 14.6 4.7 1.5 1 0 0 1 1 1 0 Intermediate filament protein CENP-F_leu_zip PF10473.9 CDW52303.1 - 0.02 14.9 17.3 2.1 8.3 8.1 3.4 1 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4164 PF13747.6 CDW52303.1 - 0.029 14.6 2.0 0.13 12.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DivIVA PF05103.13 CDW52303.1 - 0.063 13.4 1.2 0.18 11.9 1.2 1.7 1 0 0 1 1 1 0 DivIVA protein Cep57_CLD_2 PF14197.6 CDW52303.1 - 0.12 12.5 10.7 1.1 9.3 1.8 3.6 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 ABC_tran_CTD PF16326.5 CDW52303.1 - 2.9 8.2 11.8 9.4 6.6 2.9 3.4 3 0 0 3 3 3 0 ABC transporter C-terminal domain Nsp1_C PF05064.13 CDW52303.1 - 3 7.7 7.8 2 8.2 0.9 2.6 3 0 0 3 3 3 0 Nsp1-like C-terminal region CC2-LZ PF16516.5 CDW52303.1 - 4.1 7.8 9.3 7.1 7.1 0.3 3.5 2 1 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator BRE1 PF08647.11 CDW52303.1 - 8.2 6.6 9.0 5.4 7.2 2.6 3.0 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase CD20 PF04103.15 CDW52304.1 - 6.5e-07 29.6 15.9 1.8e-06 28.1 15.9 1.8 1 1 0 1 1 1 1 CD20-like family zf-MYND PF01753.18 CDW52304.1 - 2.7e-06 27.4 9.3 2.7e-06 27.4 9.3 3.8 3 1 0 3 3 3 1 MYND finger TPR_12 PF13424.6 CDW52305.1 - 1.8e-11 44.2 0.3 2e-06 28.0 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW52305.1 - 3.1e-08 33.1 0.5 0.011 15.7 0.4 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDW52305.1 - 1.7e-07 30.8 0.3 0.013 15.3 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDW52305.1 - 8.8e-06 25.4 0.0 0.075 12.9 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52305.1 - 0.00025 20.9 0.1 0.0094 15.9 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDW52305.1 - 0.0015 19.1 0.1 0.053 14.2 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52305.1 - 0.0064 16.6 0.7 0.92 9.9 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW52305.1 - 0.039 13.6 0.4 2.2 8.0 0.1 2.2 2 0 0 2 2 2 0 TPR repeat MIT PF04212.18 CDW52305.1 - 0.043 13.9 0.0 7.5 6.7 0.0 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 CDW52305.1 - 0.077 13.5 0.1 1.7 9.2 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW52305.1 - 0.098 12.0 0.5 0.21 10.9 0.5 1.6 1 1 0 1 1 1 0 MalT-like TPR region ANAPC3 PF12895.7 CDW52305.1 - 0.098 12.9 0.3 0.33 11.2 0.1 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CDW52305.1 - 0.13 12.9 0.7 4 8.3 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Lin-8 PF03353.15 CDW52305.1 - 0.32 10.5 3.8 4.2 6.9 0.1 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist EGF PF00008.27 CDW52306.1 - 2e-10 40.8 127.7 0.00021 21.5 7.4 11.1 11 1 1 12 12 12 7 EGF-like domain hEGF PF12661.7 CDW52306.1 - 2.3e-06 28.0 19.9 0.00025 21.6 6.5 11.2 10 0 0 10 10 10 3 Human growth factor-like EGF EGF_2 PF07974.13 CDW52306.1 - 6.1e-06 26.5 122.2 0.045 14.1 7.9 10.2 9 0 0 9 9 9 7 EGF-like domain FmdE PF02663.14 CDW52306.1 - 0.66 10.0 5.2 12 6.0 0.4 2.5 2 0 0 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Rad33 PF08730.10 CDW52306.1 - 2.8 7.9 4.9 23 4.9 0.5 2.4 2 0 0 2 2 2 0 Rad33 EGF PF00008.27 CDW52307.1 - 1.2e-13 51.1 71.0 0.0001 22.5 9.0 7.1 6 0 0 6 6 6 5 EGF-like domain hEGF PF12661.7 CDW52307.1 - 0.00018 22.0 58.1 0.00053 20.5 6.8 7.7 6 0 0 6 6 6 3 Human growth factor-like EGF EGF_2 PF07974.13 CDW52307.1 - 0.00027 21.2 7.0 0.00027 21.2 7.0 7.3 7 0 0 7 7 7 4 EGF-like domain DUF2815 PF10991.8 CDW52307.1 - 0.21 11.5 0.1 0.42 10.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2815) DNA_ligase_A_M PF01068.21 CDW52308.1 - 8.4e-55 185.6 0.0 1.2e-54 185.1 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CDW52308.1 - 3.1e-39 135.1 0.0 4.8e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CDW52308.1 - 3.8e-24 85.2 0.0 8.7e-24 84.0 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 CDW52308.1 - 1.8e-05 25.1 0.0 3.7e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 RNA ligase SCVP PF17619.2 CDW52308.1 - 0.011 16.5 0.0 0.031 15.1 0.0 1.7 1 0 0 1 1 1 0 Secreted clade V proteins DNA_ligase_OB_2 PF14743.6 CDW52308.1 - 0.023 14.7 0.5 5.3 7.1 0.0 2.9 3 0 0 3 3 3 0 DNA ligase OB-like domain JmjC PF02373.22 CDW52309.1 - 6.9e-39 132.8 0.6 2e-38 131.3 0.6 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 CDW52309.1 - 1.9e-17 63.7 0.0 4.6e-17 62.5 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PLU-1 PF08429.11 CDW52309.1 - 1.8e-15 57.0 9.4 1.8e-15 57.0 9.4 2.0 2 0 0 2 2 2 1 PLU-1-like protein PHD PF00628.29 CDW52309.1 - 1.7e-10 40.6 4.4 1.7e-10 40.6 4.4 3.7 3 0 0 3 3 3 2 PHD-finger zf-C5HC2 PF02928.16 CDW52309.1 - 8.4e-10 38.9 14.0 1.9e-09 37.8 12.1 2.8 2 0 0 2 2 2 1 C5HC2 zinc finger JmjN PF02375.17 CDW52309.1 - 1.2e-08 34.7 0.5 3.1e-08 33.4 0.5 1.8 1 0 0 1 1 1 1 jmjN domain Prok-RING_1 PF14446.6 CDW52309.1 - 0.0038 17.1 4.0 0.0038 17.1 4.0 3.9 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 FlgN PF05130.12 CDW52309.1 - 5.6 7.5 8.3 19 5.7 0.0 3.6 2 1 1 3 3 3 0 FlgN protein ZapB PF06005.12 CDW52310.1 - 0.026 15.0 0.5 0.026 15.0 0.5 5.2 5 0 0 5 5 5 0 Cell division protein ZapB CX PF01705.19 CDW52310.1 - 0.14 12.7 8.3 0.58 10.7 8.3 2.2 1 1 0 1 1 1 0 CX module Shugoshin_N PF07558.11 CDW52310.1 - 1.5 8.8 9.9 0.71 9.8 0.2 3.8 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region U-box PF04564.15 CDW52311.1 - 4.5e-30 103.6 0.1 8.7e-30 102.7 0.1 1.5 1 0 0 1 1 1 1 U-box domain CHIP_TPR_N PF18391.1 CDW52311.1 - 7.8e-21 74.6 9.9 1.3e-20 73.9 9.9 1.4 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_1 PF00515.28 CDW52311.1 - 1.8e-17 62.3 6.3 8.9e-08 31.6 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDW52311.1 - 4.4e-15 54.5 8.2 4.5e-05 23.2 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDW52311.1 - 6.2e-11 41.8 0.4 1.6e-07 30.8 0.0 3.2 1 1 2 3 3 3 1 TPR repeat TPR_16 PF13432.6 CDW52311.1 - 2e-10 41.2 0.2 1e-07 32.4 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52311.1 - 8.8e-10 38.0 1.0 0.00065 19.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW52311.1 - 1.7e-09 37.8 2.5 2.8e-09 37.1 2.5 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDW52311.1 - 1e-07 31.8 0.2 7.7e-05 22.8 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDW52311.1 - 3.3e-06 27.5 0.3 0.34 11.8 0.1 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW52311.1 - 3.4e-05 24.3 0.2 0.021 15.3 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDW52311.1 - 3.9e-05 23.8 6.8 0.11 12.8 0.2 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52311.1 - 0.00012 21.8 2.4 0.17 12.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat zf-NOSIP PF15906.5 CDW52311.1 - 0.00019 21.5 0.0 0.00068 19.7 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein TPR_9 PF13371.6 CDW52311.1 - 0.00094 19.3 0.1 0.017 15.2 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3808 PF10300.9 CDW52311.1 - 0.0011 17.8 1.0 0.0015 17.3 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) SRP_TPR_like PF17004.5 CDW52311.1 - 0.0053 16.8 0.4 0.0095 16.0 0.4 1.5 1 0 0 1 1 1 1 Putative TPR-like repeat SNAP PF14938.6 CDW52311.1 - 0.0058 16.1 1.6 0.016 14.7 1.6 1.7 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Coatomer_E PF04733.14 CDW52311.1 - 0.019 14.4 0.8 0.13 11.6 0.1 2.1 1 1 1 2 2 2 0 Coatomer epsilon subunit TPR_10 PF13374.6 CDW52311.1 - 0.037 13.9 3.2 4.9 7.2 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat RelB_leu_zip PF16180.5 CDW52311.1 - 0.08 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 RelB leucine zipper DUF737 PF05300.11 CDW52311.1 - 4.2 7.7 7.0 6 7.2 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) XPG_I_2 PF12813.7 CDW52312.1 - 8.9e-13 48.3 0.0 1.3e-10 41.2 0.0 2.5 2 0 0 2 2 2 2 XPG domain containing XPG_N PF00752.17 CDW52312.1 - 2.8e-06 27.7 0.0 1.2e-05 25.7 0.0 2.1 1 1 1 2 2 2 1 XPG N-terminal domain Dak1 PF02733.17 CDW52313.1 - 1.1e-102 343.1 0.0 1.9e-102 342.3 0.0 1.3 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 CDW52313.1 - 8.1e-41 139.8 0.7 1.5e-40 138.9 0.7 1.5 1 0 0 1 1 1 1 DAK2 domain TBP PF00352.21 CDW52314.1 - 9.9e-40 134.4 0.0 2.1e-20 72.4 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF2013 PF09431.10 CDW52315.1 - 2.4e-14 53.6 0.0 1.2e-12 48.1 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF2013) DnaJ PF00226.31 CDW52316.1 - 3.6e-28 97.5 3.8 4.9e-28 97.1 3.8 1.2 1 0 0 1 1 1 1 DnaJ domain SNF2_N PF00176.23 CDW52317.1 - 9.4e-73 244.9 1.7 9.4e-73 244.9 1.7 2.4 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW52317.1 - 5.5e-20 71.8 0.1 6.3e-19 68.4 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 CDW52317.1 - 7.7e-17 61.4 19.6 7.7e-17 61.4 19.6 3.7 3 0 0 3 3 3 1 HSA Bromodomain PF00439.25 CDW52317.1 - 6.1e-16 58.3 0.0 1.8e-15 56.8 0.0 1.8 1 0 0 1 1 1 1 Bromodomain BRK PF07533.16 CDW52317.1 - 6.7e-15 54.4 0.0 1.4e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 BRK domain SnAC PF14619.6 CDW52317.1 - 3e-14 53.4 11.0 3e-14 53.4 11.0 4.8 3 2 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 CDW52317.1 - 5.9e-11 42.7 0.0 5.9e-11 42.7 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit QLQ PF08880.11 CDW52317.1 - 2.4e-05 24.0 0.0 5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 QLQ DEAD PF00270.29 CDW52317.1 - 0.00028 20.7 0.0 0.00067 19.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase 7tm_1 PF00001.21 CDW52319.1 - 1.6e-26 93.3 21.9 2e-26 92.9 21.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) zf-C4 PF00105.18 CDW52320.1 - 2.5e-28 98.3 15.2 4.6e-28 97.5 14.6 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW52320.1 - 1.5e-11 44.2 1.3 8.2e-11 41.9 1.3 2.0 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor IU_nuc_hydro PF01156.19 CDW52321.1 - 3.5e-67 227.1 0.5 4.7e-67 226.7 0.5 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase TB2_DP1_HVA22 PF03134.19 CDW52322.1 - 5.9e-21 74.2 6.2 5.9e-21 74.2 6.2 1.7 2 0 0 2 2 2 1 TB2/DP1, HVA22 family DUF4807 PF16065.5 CDW52322.1 - 0.15 11.7 0.0 5.6 6.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4807) ETC_C1_NDUFA5 PF04716.14 CDW52323.1 - 6.9e-21 73.8 0.1 9e-21 73.5 0.1 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Ank_2 PF12796.7 CDW52324.1 - 1.8e-42 143.8 6.7 2e-20 73.1 0.4 3.3 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW52324.1 - 2.7e-35 119.9 18.2 1.7e-09 37.7 0.2 5.5 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW52324.1 - 5.9e-33 112.8 8.3 4.3e-09 36.7 0.2 5.0 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW52324.1 - 1.1e-31 105.3 2.0 1.3e-05 25.2 0.0 5.4 5 0 0 5 5 5 5 Ankyrin repeat Ank PF00023.30 CDW52324.1 - 1.5e-27 94.8 3.8 2.8e-06 27.5 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat DUF2492 PF10678.9 CDW52324.1 - 0.12 12.7 0.0 0.56 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2492) GCV_H PF01597.19 CDW52325.1 - 3.2e-39 133.6 0.2 4.6e-39 133.1 0.2 1.2 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 CDW52325.1 - 0.0014 18.4 0.0 0.0029 17.4 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 CDW52325.1 - 0.027 14.4 0.1 0.042 13.8 0.1 1.3 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain CENP-S PF15630.6 CDW52325.1 - 0.091 13.2 0.0 0.16 12.3 0.0 1.5 1 1 0 1 1 1 0 CENP-S protein Flavokinase PF01687.17 CDW52326.1 - 1e-27 96.6 0.1 1.7e-26 92.7 0.1 2.0 1 1 0 1 1 1 1 Riboflavin kinase RRM_1 PF00076.22 CDW52328.1 - 4.3e-82 269.9 1.0 8.8e-18 63.9 0.0 7.0 6 1 0 6 6 6 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW52328.1 - 3.8e-08 33.1 0.0 0.15 12.0 0.0 6.1 7 1 0 7 7 7 1 Occluded RNA-recognition motif RRM_7 PF16367.5 CDW52328.1 - 1.2e-06 28.6 0.0 1.8 8.7 0.0 5.6 6 0 0 6 6 6 1 RNA recognition motif RRM_Rrp7 PF17799.1 CDW52328.1 - 0.00017 21.5 0.1 39 4.0 0.0 5.4 5 1 1 6 6 6 0 Rrp7 RRM-like N-terminal domain Nup35_RRM_2 PF14605.6 CDW52328.1 - 0.00042 20.3 0.4 8.1 6.5 0.0 5.0 6 1 0 6 6 6 1 Nup53/35/40-type RNA recognition motif RRM_9 PF18444.1 CDW52328.1 - 0.0019 18.0 0.1 2.2 8.2 0.0 3.4 3 0 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.6 CDW52328.1 - 0.002 18.4 1.9 8.1 6.6 0.1 5.7 4 3 3 7 7 7 1 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 CDW52328.1 - 0.0044 17.1 0.0 11 6.2 0.0 4.7 5 0 0 5 5 5 1 RNA binding motif Limkain-b1 PF11608.8 CDW52328.1 - 0.01 15.9 0.2 16 5.6 0.0 4.3 4 1 0 4 4 4 0 Limkain b1 YlbD_coat PF14071.6 CDW52328.1 - 0.73 10.1 7.1 0.047 13.9 0.9 2.2 2 0 0 2 2 2 0 Putative coat protein Pep1_7 PF17232.2 CDW52328.1 - 4.1 7.9 7.3 6 7.4 0.2 3.9 4 0 0 4 4 4 0 Elicitor peptide 1-7 tRNA-synt_2d PF01409.20 CDW52329.1 - 3.6e-36 124.9 1.0 2.1e-19 70.0 0.1 2.8 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Evr1_Alr PF04777.13 CDW52329.1 - 5.3e-35 119.9 4.0 3.2e-17 62.8 0.5 3.0 3 0 0 3 3 2 2 Erv1 / Alr family FAD_SOX PF18371.1 CDW52329.1 - 1.8e-32 111.8 0.2 1.1e-15 57.9 0.1 2.6 2 0 0 2 2 2 2 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase FDX-ACB PF03147.14 CDW52329.1 - 6.3e-22 77.8 0.0 1.4e-21 76.7 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Thioredoxin PF00085.20 CDW52329.1 - 5.5e-20 71.3 0.5 1.4e-13 50.7 0.1 2.7 2 0 0 2 2 2 2 Thioredoxin Methyltransf_11 PF08241.12 CDW52329.1 - 8e-16 58.5 0.0 2.5e-15 56.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW52329.1 - 1.5e-13 50.9 0.0 5.6e-13 49.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW52329.1 - 1.8e-11 44.6 0.0 4.9e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW52329.1 - 1.8e-09 37.6 0.0 5.3e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW52329.1 - 1.2e-07 32.3 0.0 3.3e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDW52329.1 - 0.00016 21.1 0.0 0.00029 20.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CDW52329.1 - 0.014 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_8 PF05148.15 CDW52329.1 - 0.02 14.7 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase eIF-5_eIF-2B PF01873.17 CDW52329.1 - 0.028 14.3 0.5 1.1 9.1 0.0 3.2 3 0 0 3 3 3 0 Domain found in IF2B/IF5 Ribosomal_S19e PF01090.19 CDW52330.1 - 1.9e-56 189.6 0.0 2.1e-56 189.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_12 PF08461.10 CDW52330.1 - 0.019 14.9 0.1 0.054 13.4 0.0 1.8 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain PCI PF01399.27 CDW52331.1 - 1.5e-19 70.4 2.9 1.6e-19 70.3 0.6 2.2 2 0 0 2 2 2 1 PCI domain ParcG PF10274.9 CDW52331.1 - 0.0085 16.2 0.4 0.035 14.2 0.2 2.0 2 0 0 2 2 2 1 Parkin co-regulated protein PyrI PF01948.18 CDW52331.1 - 0.053 13.8 0.1 0.14 12.4 0.1 1.8 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain TPR_2 PF07719.17 CDW52331.1 - 0.063 13.4 1.2 1.5 9.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52331.1 - 0.085 12.9 0.7 3.6 7.8 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat D_CNTX PF17492.2 CDW52332.1 - 3.2 8.0 12.7 9.6 6.5 0.0 3.2 2 1 0 2 2 2 0 Delta Ctenitoxins PAN_1 PF00024.26 CDW52333.1 - 3.6e-23 81.3 40.1 2.5e-07 30.5 2.6 5.5 5 0 0 5 5 5 5 PAN domain FR47 PF08445.10 CDW52334.1 - 1.1e-07 31.7 0.0 1.9e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 CDW52334.1 - 0.00014 22.1 0.0 0.00025 21.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDW52334.1 - 0.0087 16.5 0.0 0.016 15.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDW52334.1 - 0.071 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Gly_acyl_tr_C PF08444.10 CDW52334.1 - 0.1 12.9 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region MMR_HSR1 PF01926.23 CDW52335.1 - 6e-15 55.3 0.0 6.5e-14 52.0 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW52335.1 - 4e-06 26.9 0.0 9.8e-05 22.3 0.0 2.4 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 CDW52335.1 - 3e-05 23.6 0.0 0.00011 21.8 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDW52335.1 - 0.0073 15.9 0.0 0.84 9.1 0.0 2.9 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 CDW52335.1 - 0.018 15.6 0.1 0.2 12.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.16 CDW52335.1 - 0.021 14.2 0.0 0.032 13.5 0.0 1.5 1 1 0 1 1 1 0 AIG1 family DUF815 PF05673.13 CDW52335.1 - 0.05 12.8 0.0 0.077 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IIGP PF05049.13 CDW52335.1 - 0.2 10.7 0.0 0.34 9.9 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Glyco_hydro_56 PF01630.18 CDW52335.1 - 0.24 10.4 0.0 0.59 9.1 0.0 1.6 2 0 0 2 2 2 0 Hyaluronidase Pkinase PF00069.25 CDW52336.1 - 1.9e-24 86.5 0.0 2.3e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52336.1 - 1.5e-16 60.4 0.0 2e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW52336.1 - 0.0023 16.8 0.0 0.0034 16.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW52336.1 - 0.058 13.3 0.0 3.9 7.3 0.0 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family OATP PF03137.20 CDW52337.1 - 1.2e-154 515.6 18.1 1.7e-154 515.2 18.1 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 CDW52337.1 - 6.2e-18 64.8 37.2 8.8e-17 61.1 13.8 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily Kazal_2 PF07648.15 CDW52337.1 - 2.6e-07 30.6 1.3 7.9e-07 29.1 1.3 1.8 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 CDW52337.1 - 0.0002 21.3 4.0 0.00058 19.8 4.0 1.7 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain ING PF12998.7 CDW52338.1 - 1.1e-11 45.1 1.7 9.2e-06 26.2 0.3 2.4 1 1 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CDW52338.1 - 0.0025 17.7 13.9 0.005 16.7 13.9 1.5 1 0 0 1 1 1 1 PHD-finger Profilin PF00235.19 CDW52339.1 - 5.6e-35 120.4 0.2 6.3e-35 120.2 0.2 1.0 1 0 0 1 1 1 1 Profilin SNX17_FERM_C PF18116.1 CDW52340.1 - 9e-23 80.4 0.4 2.8e-22 78.8 0.4 1.8 1 1 0 1 1 1 1 Sorting Nexin 17 FERM C-terminal domain PX PF00787.24 CDW52340.1 - 3.6e-07 30.2 0.1 6.6e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 PX domain Ras PF00071.22 CDW52341.1 - 4.2e-59 198.8 0.4 5.4e-59 198.4 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52341.1 - 2.8e-36 124.4 0.2 4.4e-36 123.7 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52341.1 - 1.5e-15 57.1 0.1 1.9e-15 56.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW52341.1 - 9.2e-07 28.6 0.1 5.8e-06 26.0 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CDW52341.1 - 1e-05 25.1 0.0 1.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDW52341.1 - 4.2e-05 23.6 0.0 7.1e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW52341.1 - 0.00012 21.6 0.2 0.00014 21.3 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDW52341.1 - 0.00022 21.2 0.1 0.12 12.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 CDW52341.1 - 0.0023 17.5 0.1 0.043 13.3 0.1 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 CDW52341.1 - 0.018 14.9 0.1 0.053 13.3 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 CDW52341.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TetR_C_16 PF17920.1 CDW52341.1 - 0.16 12.2 0.0 0.52 10.6 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Pkinase PF00069.25 CDW52342.1 - 7.5e-49 166.4 0.1 1.4e-48 165.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52342.1 - 1.4e-23 83.6 0.0 2.3e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW52342.1 - 6.8e-11 42.0 0.0 1.9e-10 40.6 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 CDW52342.1 - 0.00084 18.8 0.2 0.0016 17.8 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDW52342.1 - 0.0011 18.6 0.9 0.0022 17.6 0.9 1.4 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 CDW52342.1 - 0.081 12.5 0.0 0.27 10.8 0.0 1.8 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF3510 PF12022.8 CDW52342.1 - 0.54 10.7 4.2 0.27 11.6 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) Ribosomal_L7Ae PF01248.26 CDW52343.1 - 5.1e-24 83.8 0.0 6e-24 83.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.6 CDW52343.1 - 0.02 15.0 0.0 0.025 14.7 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Tetraspanin PF00335.20 CDW52344.1 - 1.4e-15 57.7 0.8 2e-15 57.1 0.8 1.2 1 0 0 1 1 1 1 Tetraspanin family Phage_holin_1 PF04531.13 CDW52344.1 - 2 9.0 4.5 7.1 7.2 0.1 2.4 2 1 0 2 2 2 0 Bacteriophage holin RTC PF01137.21 CDW52345.1 - 2.3e-83 278.8 0.7 2.6e-83 278.6 0.7 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 CDW52345.1 - 1.7e-12 47.7 0.1 3.4e-12 46.8 0.1 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Cnd1 PF12717.7 CDW52347.1 - 0.00025 21.1 0.8 0.46 10.5 0.1 2.9 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDW52347.1 - 0.0037 15.9 1.3 0.0089 14.6 1.2 1.7 1 1 0 1 1 1 1 Adaptin N terminal region DUF1548 PF07579.11 CDW52347.1 - 0.012 15.9 0.0 0.03 14.7 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) CLASP_N PF12348.8 CDW52347.1 - 0.018 14.6 1.3 0.05 13.2 1.1 1.8 1 1 0 2 2 2 0 CLASP N terminal RIX1 PF08167.12 CDW52347.1 - 0.024 14.4 0.7 0.064 13.0 0.7 1.8 1 1 0 1 1 1 0 rRNA processing/ribosome biogenesis TIP120 PF08623.10 CDW52347.1 - 0.1 12.4 1.2 0.6 9.9 1.2 2.1 1 1 0 1 1 1 0 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 CDW52347.1 - 0.29 11.5 1.5 0.93 9.9 0.1 2.5 3 0 0 3 3 3 0 HEAT repeats Ras PF00071.22 CDW52349.1 - 1e-55 187.8 0.1 1.3e-55 187.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52349.1 - 2.3e-21 76.3 0.0 3.3e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52349.1 - 2.8e-11 43.2 0.0 3.4e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW52349.1 - 1.4e-08 34.5 0.3 4.7e-08 32.8 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW52349.1 - 8.1e-05 22.6 0.4 0.069 13.0 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDW52349.1 - 0.00016 21.7 0.0 0.00036 20.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 CDW52349.1 - 0.00093 19.2 0.0 0.0019 18.2 0.0 1.5 1 1 1 2 2 2 1 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 CDW52349.1 - 0.0066 16.3 1.5 0.041 13.7 0.1 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 CDW52349.1 - 0.046 13.2 0.1 0.29 10.7 0.1 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_16 PF13191.6 CDW52349.1 - 0.067 13.6 0.3 0.18 12.2 0.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain EF-hand_1 PF00036.32 CDW52350.1 - 0.0002 20.7 0.1 0.00069 19.0 0.1 2.0 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CDW52350.1 - 0.00078 19.2 0.1 0.003 17.4 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 CDW52350.1 - 0.0022 17.4 0.2 0.014 14.9 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CDW52350.1 - 0.0049 17.3 1.3 0.0092 16.4 0.9 1.7 1 1 0 1 1 1 1 EF-hand domain pair DUF2288 PF10052.9 CDW52350.1 - 0.033 14.3 0.0 3.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2288) EF_assoc_2 PF08356.12 CDW52350.1 - 0.044 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 EF hand associated EF-hand_8 PF13833.6 CDW52350.1 - 0.059 13.2 0.3 0.19 11.6 0.3 1.8 1 0 0 1 1 1 0 EF-hand domain pair Atg14 PF10186.9 CDW52351.1 - 8.1e-17 61.3 6.8 1.9e-16 60.1 6.8 1.6 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Sec8_exocyst PF04048.14 CDW52351.1 - 0.012 15.5 0.2 0.024 14.5 0.2 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain ATG16 PF08614.11 CDW52351.1 - 0.2 11.8 7.8 0.049 13.8 4.0 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF745 PF05335.13 CDW52351.1 - 1.1 8.9 3.2 2.4 7.8 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Toxin_3 PF00537.18 CDW52352.1 - 0.002 18.3 18.7 0.024 14.8 5.3 2.3 1 1 1 2 2 2 2 Scorpion toxin-like domain Gamma-thionin PF00304.20 CDW52352.1 - 0.017 15.4 5.8 0.017 15.4 5.8 2.6 2 1 0 2 2 2 0 Gamma-thionin family SLR1-BP PF07333.12 CDW52352.1 - 0.028 14.9 16.6 0.39 11.2 5.7 2.2 1 1 1 2 2 2 0 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) Ribosomal_S9 PF00380.19 CDW52353.1 - 5.2e-10 39.9 0.1 9.2e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 NDUF_B4 PF07225.12 CDW52354.1 - 7.6e-28 96.9 0.2 9.8e-28 96.5 0.2 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Membralin PF09746.9 CDW52355.1 - 5.2e-102 341.8 2.7 2.1e-101 339.7 2.7 1.9 1 1 0 1 1 1 1 Tumour-associated protein Adeno_GP19K PF04881.13 CDW52356.1 - 4.8e-05 23.4 0.1 0.0001 22.3 0.1 1.5 1 0 0 1 1 1 1 Adenovirus GP19K EGF PF00008.27 CDW52356.1 - 0.00059 20.1 3.0 0.00059 20.1 3.0 2.7 2 1 0 2 2 2 1 EGF-like domain EGF_2 PF07974.13 CDW52356.1 - 0.0027 18.0 7.6 0.0027 18.0 7.6 2.4 2 0 0 2 2 2 1 EGF-like domain UPF0242 PF06785.11 CDW52356.1 - 0.064 13.4 1.7 0.71 9.9 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Adeno_E3_CR2 PF02439.15 CDW52356.1 - 0.12 12.2 1.4 0.24 11.2 1.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 hEGF PF12661.7 CDW52356.1 - 3.7 8.3 10.7 0.2 12.3 3.3 2.8 2 1 0 2 2 2 0 Human growth factor-like EGF GST_C_6 PF17171.4 CDW52357.1 - 6.1e-13 48.4 1.1 8.2e-13 47.9 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CDW52357.1 - 0.0012 19.1 2.7 0.47 10.8 0.4 2.4 2 0 0 2 2 2 2 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 CDW52357.1 - 0.047 13.7 0.0 0.075 13.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GREB1 PF15782.5 CDW52358.1 - 0.15 9.1 14.3 0.21 8.7 14.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_23 PF13476.6 CDW52358.1 - 0.17 12.4 7.2 0.31 11.5 7.2 1.5 1 0 0 1 1 1 0 AAA domain SNF PF00209.18 CDW52360.1 - 1.7e-150 502.2 36.8 1.5e-147 492.5 30.4 2.0 1 1 0 2 2 2 2 Sodium:neurotransmitter symporter family TMEMspv1-c74-12 PF11044.8 CDW52360.1 - 0.032 14.2 0.1 0.17 11.9 0.1 2.2 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein FRG1 PF06229.12 CDW52361.1 - 4.4e-48 163.5 0.0 6.1e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 CDW52361.1 - 6.3e-09 36.0 0.0 3.3e-05 24.1 0.0 2.6 2 1 1 3 3 3 2 Fascin domain DUF1754 PF08555.10 CDW52361.1 - 7.2e-05 23.5 3.2 0.00017 22.3 3.2 1.6 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) LapA_dom PF06305.11 CDW52363.1 - 0.076 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain ADK PF00406.22 CDW52364.1 - 1.2e-40 139.1 0.0 1.4e-40 138.8 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDW52364.1 - 1.3e-32 113.1 0.0 1.6e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDW52364.1 - 1.6e-08 35.1 0.0 2.2e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDW52364.1 - 1.9e-06 28.1 0.0 3e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CDW52364.1 - 0.00083 19.8 0.0 0.0018 18.7 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Thymidylate_kin PF02223.17 CDW52364.1 - 0.0049 16.6 0.0 0.97 9.1 0.0 2.1 2 0 0 2 2 2 2 Thymidylate kinase Cytidylate_kin PF02224.18 CDW52364.1 - 0.01 15.6 0.0 0.049 13.4 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase NACHT PF05729.12 CDW52364.1 - 0.01 15.8 0.0 0.19 11.6 0.0 2.3 1 1 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 CDW52364.1 - 0.042 14.1 0.1 0.16 12.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDW52364.1 - 0.065 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 CDW52364.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CDW52364.1 - 0.11 12.9 0.0 0.25 11.8 0.0 1.9 1 1 0 1 1 1 0 RNA helicase Methyltransf_16 PF10294.9 CDW52365.1 - 5.6e-13 49.0 0.0 8.7e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_11 PF08241.12 CDW52365.1 - 0.0011 19.6 0.0 0.0019 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CENP-S PF15630.6 CDW52365.1 - 0.0014 18.9 0.1 0.0031 17.9 0.1 1.5 1 0 0 1 1 1 1 CENP-S protein Methyltransf_25 PF13649.6 CDW52365.1 - 0.0017 19.0 0.0 0.0032 18.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW52365.1 - 0.0028 17.5 0.0 0.0042 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW52365.1 - 0.16 12.7 0.0 0.27 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Enolase_C PF00113.22 CDW52366.1 - 2.4e-149 496.5 0.0 3.7e-149 495.8 0.0 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 CDW52366.1 - 2.5e-57 192.7 0.1 4e-57 192.0 0.1 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MAAL_C PF07476.11 CDW52366.1 - 1.8e-06 27.3 0.5 1.8e-06 27.3 0.5 1.5 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus MR_MLE_C PF13378.6 CDW52366.1 - 2.4e-06 27.3 0.0 4.1e-06 26.5 0.0 1.4 1 1 0 1 1 1 1 Enolase C-terminal domain-like Peptidase_M14 PF00246.24 CDW52367.1 - 5.5e-32 111.7 0.1 9.6e-32 110.9 0.1 1.4 1 1 0 1 1 1 1 Zinc carboxypeptidase I_LWEQ PF01608.17 CDW52368.1 - 4.3e-65 218.6 165.0 4.8e-49 166.5 16.3 18.1 9 2 8 19 19 19 9 I/LWEQ domain Talin_middle PF09141.10 CDW52368.1 - 1.4e-54 184.5 1.7 1.4e-54 184.5 1.7 13.7 7 2 6 14 14 14 4 Talin, middle domain VBS PF08913.10 CDW52368.1 - 7.9e-37 126.5 0.2 7.9e-37 126.5 0.2 10.1 12 2 3 15 15 11 3 Vinculin Binding Site FERM_f0 PF16511.5 CDW52368.1 - 3.6e-36 123.3 0.1 8.9e-35 118.9 0.0 3.2 3 0 0 3 3 3 1 N-terminal or F0 domain of Talin-head FERM FERM_M PF00373.18 CDW52368.1 - 4e-25 88.5 0.1 3.6e-24 85.4 0.0 2.9 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 CDW52368.1 - 1.4e-22 79.4 0.3 4.4e-20 71.4 0.2 2.9 2 0 0 2 2 2 1 FERM N-terminal domain PTB PF08416.13 CDW52368.1 - 0.014 15.6 0.2 3.9 7.6 0.0 3.3 2 0 0 2 2 2 0 Phosphotyrosine-binding domain CRIC_ras_sig PF10534.9 CDW52368.1 - 0.021 15.0 0.0 0.021 15.0 0.0 7.2 7 0 0 7 7 7 0 Connector enhancer of kinase suppressor of ras RecG_N PF17190.4 CDW52368.1 - 0.11 13.2 0.0 1.4 9.7 0.0 3.0 1 0 0 1 1 1 0 RecG N-terminal helical domain IRS PF02174.17 CDW52368.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 PTB domain (IRS-1 type) H-kinase_dim PF02895.14 CDW52368.1 - 1 9.8 6.6 7.8 7.0 0.0 5.5 4 0 0 4 4 4 0 Signal transducing histidine kinase, homodimeric domain RAC_head PF16717.5 CDW52368.1 - 2.2 9.3 5.7 9.8 7.2 0.1 4.5 3 0 0 3 3 3 0 Ribosome-associated complex head domain Lig_chan-Glu_bd PF10613.9 CDW52369.1 - 7.8e-06 26.1 0.0 1.2e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 CDW52369.1 - 0.00085 18.8 0.0 0.0013 18.2 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF2678 PF10856.8 CDW52369.1 - 0.08 12.9 1.9 11 5.9 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2678) Tad PF13400.6 CDW52369.1 - 1.3 9.4 0.0 1.3 9.4 0.0 2.8 4 0 0 4 4 4 0 Putative Flp pilus-assembly TadE/G-like ABC_membrane PF00664.23 CDW52370.1 - 1.2e-49 169.4 19.8 1.2e-49 169.4 19.8 3.4 3 1 0 3 3 3 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDW52370.1 - 1.7e-34 119.3 0.0 3.3e-34 118.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDW52370.1 - 3.8e-07 29.8 0.2 0.00024 20.6 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDW52370.1 - 0.00074 19.8 0.0 0.0036 17.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW52370.1 - 0.0023 18.4 0.0 0.0069 16.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDW52370.1 - 0.0067 16.1 0.0 0.022 14.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDW52370.1 - 0.0093 15.9 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 CDW52370.1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDW52370.1 - 0.036 13.2 0.0 0.062 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_21 PF13304.6 CDW52370.1 - 0.089 12.6 0.0 4.8 6.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 CDW52370.1 - 0.17 11.9 0.0 0.69 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 CDW52370.1 - 0.17 10.6 0.0 0.26 10.0 0.0 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_15 PF13175.6 CDW52370.1 - 0.26 11.0 0.0 0.41 10.3 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Peptidase_C78 PF07910.13 CDW52371.1 - 4.7e-42 143.9 0.0 6.4e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 CDW52371.1 - 0.11 11.9 1.7 0.21 11.0 0.4 2.1 1 1 1 2 2 2 0 Peptidase family C54 MukB PF04310.12 CDW52372.1 - 8.3e-05 22.5 0.3 0.00012 22.0 0.3 1.2 1 0 0 1 1 1 1 MukB N-terminal CALCOCO1 PF07888.11 CDW52372.1 - 0.019 13.8 7.2 0.027 13.3 7.2 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like NBP1 PF08537.10 CDW52372.1 - 0.025 14.0 2.9 0.038 13.4 2.9 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 THOC7 PF05615.13 CDW52372.1 - 0.049 13.9 7.7 0.09 13.1 7.7 1.5 1 0 0 1 1 1 0 Tho complex subunit 7 Rx_N PF18052.1 CDW52372.1 - 0.064 13.5 2.8 7.2 7.0 2.0 2.9 2 1 0 2 2 2 0 Rx N-terminal domain AIP3 PF03915.13 CDW52372.1 - 0.2 10.7 6.5 3.1 6.8 1.9 2.6 2 1 1 3 3 3 0 Actin interacting protein 3 Med9 PF07544.13 CDW52372.1 - 2.1 8.5 10.1 0.42 10.7 5.5 2.1 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Cnn_1N PF07989.11 CDW52372.1 - 2.4 8.4 11.6 5.4e+02 0.8 11.6 2.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Csm1_N PF18504.1 CDW52372.1 - 6.3 7.2 11.9 6.2 7.2 0.5 3.1 1 1 2 3 3 3 0 Csm1 N-terminal domain FAM76 PF16046.5 CDW52372.1 - 7.6 5.8 5.3 24 4.2 5.3 1.8 1 1 0 1 1 1 0 FAM76 protein Golgin_A5 PF09787.9 CDW52374.1 - 2.2e-38 132.4 32.5 3e-38 132.0 32.5 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 GAS PF13851.6 CDW52374.1 - 0.0031 16.9 19.6 0.0031 16.9 19.6 2.2 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Fungal_TACC PF12709.7 CDW52374.1 - 0.04 14.3 4.7 0.04 14.3 4.7 3.6 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins JIP_LZII PF16471.5 CDW52374.1 - 0.049 13.8 1.9 0.049 13.8 1.9 4.2 2 1 3 5 5 5 0 JNK-interacting protein leucine zipper II HALZ PF02183.18 CDW52374.1 - 0.053 13.8 5.4 2.5 8.4 0.4 3.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper Tropomyosin_1 PF12718.7 CDW52374.1 - 0.19 11.9 35.2 0.92 9.7 4.7 3.1 1 1 2 3 3 3 0 Tropomyosin like OmpH PF03938.14 CDW52374.1 - 0.2 12.0 29.0 0.28 11.5 11.9 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Vpu PF00558.19 CDW52374.1 - 0.26 11.1 4.6 0.14 12.0 2.1 1.9 1 1 0 1 1 1 0 Vpu protein HMMR_N PF15905.5 CDW52374.1 - 0.38 10.2 31.9 1.3 8.4 32.3 1.5 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF948 PF06103.11 CDW52374.1 - 0.45 10.8 11.6 1.3 9.3 1.5 3.1 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 CDW52374.1 - 0.75 9.1 20.3 2.8 7.2 14.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 CDW52374.1 - 3 8.5 35.9 9.4 6.9 14.2 3.8 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Seryl_tRNA_N PF02403.22 CDW52374.1 - 3.6 7.9 24.7 1.5 9.1 10.3 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FUSC PF04632.12 CDW52374.1 - 5.2 5.5 10.8 6.3 5.2 10.8 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family FapA PF03961.13 CDW52374.1 - 5.2 5.5 24.8 4.7 5.7 9.2 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A ATG16 PF08614.11 CDW52374.1 - 7.6 6.7 36.7 3.7 7.7 12.7 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) zf-C2H2 PF00096.26 CDW52375.1 - 2.3e-23 81.3 34.7 3.1e-05 24.2 2.3 6.2 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW52375.1 - 3.4e-18 64.7 31.3 0.00085 20.0 1.9 5.8 5 0 0 5 5 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW52375.1 - 9.4e-12 44.8 37.3 9.3e-07 29.0 1.1 5.6 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW52375.1 - 2.2e-09 37.3 15.2 0.078 13.3 0.6 5.1 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW52375.1 - 1.3e-06 28.6 20.9 0.078 13.4 2.4 5.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 CDW52375.1 - 0.027 14.6 14.2 1.3 9.2 1.0 4.7 3 1 2 5 5 5 0 Zinc ribbon domain zf-BED PF02892.15 CDW52375.1 - 0.11 12.5 22.6 0.22 11.6 1.5 4.7 1 1 3 4 4 4 0 BED zinc finger zf-C2H2_6 PF13912.6 CDW52375.1 - 0.14 12.2 32.0 0.1 12.6 1.2 5.4 4 1 1 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CDW52375.1 - 0.25 11.7 22.1 2.6 8.4 2.0 4.9 1 1 4 5 5 5 0 C2H2 type zinc-finger (2 copies) Elf1 PF05129.13 CDW52375.1 - 6.1 7.0 16.3 5.8 7.0 3.7 3.2 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like NinD PF17466.2 CDW52376.1 - 0.05 13.7 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function TOPRIM_C PF16898.5 CDW52376.1 - 0.059 13.7 0.4 0.099 12.9 0.4 1.4 1 0 0 1 1 1 0 C-terminal associated domain of TOPRIM 2OG-FeII_Oxy_2 PF13532.6 CDW52377.1 - 5.2e-08 33.3 0.2 9.8e-08 32.4 0.2 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UPF0220 PF05255.11 CDW52378.1 - 8.3e-41 139.3 5.1 9.8e-41 139.1 5.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) p53-inducible11 PF14936.6 CDW52378.1 - 0.055 13.5 0.2 0.079 13.0 0.2 1.4 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 SieB PF14163.6 CDW52378.1 - 2.2 7.8 4.5 0.33 10.4 0.5 1.8 2 0 0 2 2 2 0 Super-infection exclusion protein B Oxidored_q2 PF00420.24 CDW52379.1 - 0.42 10.3 4.2 0.54 9.9 0.9 2.0 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF202 PF02656.15 CDW52379.1 - 1.1 9.7 3.4 4.8 7.7 3.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Ndc1_Nup PF09531.10 CDW52381.1 - 9.4e-05 21.3 12.3 0.00019 20.3 6.7 2.5 1 1 0 2 2 2 2 Nucleoporin protein Ndc1-Nup COX1 PF00115.20 CDW52381.1 - 0.0042 16.0 6.3 0.0061 15.5 6.3 1.2 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Ribosomal_S12 PF17487.2 CDW52381.1 - 8.9 7.1 19.8 0.41 11.4 3.2 3.0 3 0 0 3 3 3 0 Ribosomal protein S12 7TM_GPCR_Srsx PF10320.9 CDW52382.1 - 9.4e-13 48.1 19.3 1.2e-12 47.8 19.3 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 CDW52382.1 - 4.7e-08 32.7 17.4 7.3e-08 32.0 17.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW52382.1 - 0.18 11.4 22.9 0.013 15.2 16.1 2.2 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx DNase_II PF03265.15 CDW52383.1 - 4.5e-47 160.9 0.0 5.1e-47 160.7 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II DNase_II PF03265.15 CDW52384.1 - 2.6e-40 138.7 0.7 3.3e-40 138.4 0.7 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II BrkDBD PF09607.10 CDW52385.1 - 3.3e-14 52.4 0.1 4.6e-14 51.9 0.1 1.1 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_28 PF13518.6 CDW52385.1 - 0.0003 20.9 0.1 0.00085 19.4 0.2 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDW52385.1 - 0.0059 16.4 0.0 0.0083 15.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_1 PF01527.20 CDW52385.1 - 0.011 16.0 0.1 0.014 15.7 0.1 1.2 1 0 0 1 1 1 0 Transposase HTH_29 PF13551.6 CDW52385.1 - 0.045 13.8 0.1 0.067 13.2 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Carb_bind PF10645.9 CDW52386.1 - 0.0039 17.4 12.0 0.0039 17.4 12.0 3.5 2 1 0 3 3 3 2 Carbohydrate binding TPR_2 PF07719.17 CDW52387.1 - 2e-40 133.6 30.5 0.00034 20.5 0.0 11.9 12 0 0 12 12 12 9 Tetratricopeptide repeat TPR_1 PF00515.28 CDW52387.1 - 8.4e-40 133.0 23.7 8.3e-06 25.4 0.1 11.4 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_12 PF13424.6 CDW52387.1 - 5.3e-35 119.6 25.4 1.1e-08 35.2 1.0 8.8 6 2 2 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52387.1 - 1.1e-26 90.7 27.9 0.00089 19.3 0.3 10.5 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52387.1 - 2.4e-25 86.7 20.0 0.0058 16.6 0.3 11.4 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_10 PF13374.6 CDW52387.1 - 1.2e-18 66.3 32.3 3.3e-06 26.8 0.1 10.5 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_11 PF13414.6 CDW52387.1 - 3e-18 65.2 14.3 0.00029 20.5 0.0 8.8 8 1 1 9 9 9 4 TPR repeat TPR_14 PF13428.6 CDW52387.1 - 1.4e-17 62.8 16.5 0.24 12.3 0.0 10.8 6 3 4 11 11 11 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDW52387.1 - 6.4e-16 58.7 15.4 7.5e-05 23.3 1.7 8.4 6 2 3 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 CDW52387.1 - 4.2e-15 56.0 16.3 0.0017 18.8 0.3 7.6 5 3 2 8 8 8 5 Tetratricopeptide repeat TPR_6 PF13174.6 CDW52387.1 - 2.6e-14 52.8 26.3 0.074 13.7 0.1 10.3 11 0 0 11 11 9 5 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW52387.1 - 5e-14 52.3 23.2 3e-06 27.4 4.3 5.9 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CDW52387.1 - 2e-09 37.2 11.0 1.2 9.7 0.1 7.9 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_4 PF07721.14 CDW52387.1 - 1.8e-08 34.2 1.6 0.93 10.3 0.0 6.1 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW52387.1 - 2.3e-06 27.7 1.1 0.056 13.6 0.0 5.2 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW52387.1 - 0.00062 19.2 9.4 0.0026 17.2 0.4 3.8 3 1 1 4 4 4 1 MalT-like TPR region PPR PF01535.20 CDW52387.1 - 0.0014 18.8 10.1 9.3 6.8 0.0 7.5 8 0 0 8 8 8 0 PPR repeat PknG_TPR PF16918.5 CDW52387.1 - 0.0017 17.1 0.6 0.14 10.8 0.0 2.8 3 0 0 3 3 3 1 Protein kinase G tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW52387.1 - 0.0035 17.4 12.3 0.89 9.7 0.0 6.0 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat NARP1 PF12569.8 CDW52387.1 - 0.0074 15.2 0.1 0.0074 15.2 0.1 3.1 3 1 0 3 3 3 1 NMDA receptor-regulated protein 1 DUF5588 PF17826.1 CDW52387.1 - 0.008 15.1 0.8 0.038 12.9 0.1 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5588) BTAD PF03704.17 CDW52387.1 - 0.04 14.4 0.4 0.04 14.4 0.4 3.8 3 2 1 4 4 4 0 Bacterial transcriptional activator domain YfiO PF13525.6 CDW52387.1 - 0.14 11.9 7.3 1.7 8.3 1.5 2.8 2 0 0 2 2 2 0 Outer membrane lipoprotein Coatomer_E PF04733.14 CDW52387.1 - 0.15 11.4 7.0 2.9 7.2 0.1 3.9 3 1 2 5 5 5 0 Coatomer epsilon subunit MIT PF04212.18 CDW52387.1 - 1.1 9.4 24.3 45 4.2 0.0 8.7 8 1 0 8 8 8 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 CDW52387.1 - 1.5 9.6 12.5 8.4 7.2 0.2 5.8 5 1 1 6 6 6 0 Sel1 repeat RB_B PF01857.20 CDW52388.1 - 1.9e-36 125.0 2.3 2.9e-36 124.4 1.1 1.9 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain RB_A PF01858.17 CDW52388.1 - 9.6e-26 90.8 2.0 1.4e-25 90.3 0.6 2.0 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain DUF3452 PF11934.8 CDW52388.1 - 1.7e-13 50.3 0.4 1.3e-12 47.5 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3452) PITH PF06201.13 CDW52389.1 - 2.2e-34 118.9 0.0 3.6e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 CDW52389.1 - 2.4e-17 62.8 0.0 1.9e-12 47.0 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin TRIC PF05197.13 CDW52390.1 - 1.2e-79 266.4 6.5 2.4e-52 177.3 4.0 2.2 1 1 1 2 2 2 2 TRIC channel VPS13_C PF16909.5 CDW52391.1 - 1.5e-57 194.2 3.0 9.7e-53 178.6 0.2 2.7 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 CDW52391.1 - 1.6e-54 185.2 7.2 1.6e-50 172.2 5.0 4.3 3 1 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 CDW52391.1 - 2e-42 145.3 3.0 7.6e-23 81.2 0.0 6.1 4 2 1 6 6 6 5 Repeating coiled region of VPS13 Chorein_N PF12624.7 CDW52391.1 - 2.3e-34 118.0 0.2 6e-34 116.6 0.2 1.8 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 SHR-BD PF06650.12 CDW52391.1 - 7.3e-08 32.1 0.1 3.8e-06 26.5 0.1 2.6 1 1 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 CDW52391.1 - 9.2e-05 22.7 0.1 0.00041 20.6 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Chromadorea_ALT PF05535.12 CDW52393.1 - 7.6e-08 32.4 0.4 1.4e-07 31.6 0.4 1.5 1 0 0 1 1 1 1 Chromadorea ALT protein ABC2_membrane_3 PF12698.7 CDW52395.1 - 8.2e-58 196.2 41.6 1e-38 133.3 26.1 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 CDW52395.1 - 3e-51 173.5 0.0 1.3e-24 87.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDW52395.1 - 4.3e-20 72.7 5.6 2.2e-07 31.0 0.0 4.2 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDW52395.1 - 5.2e-06 27.1 1.5 0.044 14.3 0.1 2.2 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 CDW52395.1 - 0.00059 19.3 0.0 11 5.4 0.0 3.9 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDW52395.1 - 0.0014 18.5 0.2 0.86 9.5 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CDW52395.1 - 0.002 17.8 3.4 0.25 11.1 0.2 2.9 3 0 0 3 3 3 2 P-loop containing region of AAA domain MukB PF04310.12 CDW52395.1 - 0.003 17.4 0.8 0.044 13.6 0.1 2.4 2 0 0 2 2 2 1 MukB N-terminal DUF4162 PF13732.6 CDW52395.1 - 0.0085 16.8 0.0 2.7 8.8 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_27 PF13514.6 CDW52395.1 - 0.058 13.0 0.1 5.9 6.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CDW52395.1 - 0.11 12.6 2.2 1.6 8.8 0.3 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 CDW52395.1 - 0.28 11.3 2.0 18 5.5 0.2 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF2721 PF11026.8 CDW52395.1 - 2.4 8.1 0.0 2.4 8.1 0.0 5.1 6 0 0 6 6 5 0 Protein of unknown function (DUF2721) Pkinase PF00069.25 CDW52396.1 - 7.7e-138 458.2 0.0 4.8e-68 229.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52396.1 - 1.7e-69 234.0 0.0 1.7e-36 125.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDW52396.1 - 4.4e-14 52.5 0.0 3.2e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CDW52396.1 - 2e-10 40.1 0.0 0.00027 19.9 0.0 2.4 2 1 0 2 2 2 2 Fungal protein kinase Kdo PF06293.14 CDW52396.1 - 3.9e-09 36.2 0.1 0.00079 18.8 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW52396.1 - 2.5e-08 34.1 0.0 0.01 15.8 0.0 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_C PF00433.24 CDW52396.1 - 2.4e-07 31.4 0.6 8.4e-07 29.6 0.6 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain YrbL-PhoP_reg PF10707.9 CDW52396.1 - 0.00081 19.0 0.0 0.26 10.8 0.0 2.3 2 0 0 2 2 2 2 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 CDW52396.1 - 0.0022 17.0 0.3 0.013 14.5 0.1 1.9 2 0 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 CDW52396.1 - 0.0078 15.8 0.1 0.48 10.0 0.0 2.5 2 1 0 2 2 2 1 RIO1 family FTA2 PF13095.6 CDW52396.1 - 0.014 15.1 0.0 4.4 6.9 0.0 2.9 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 CDW52396.1 - 0.08 12.5 0.0 1.7 8.2 0.0 2.2 2 0 0 2 2 2 0 Choline/ethanolamine kinase PALP PF00291.25 CDW52397.1 - 6.3e-59 199.8 1.1 1.8e-52 178.6 0.7 2.0 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme Zip PF02535.22 CDW52398.1 - 4.5e-42 144.5 14.5 2.9e-32 112.2 7.6 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter Abhydrolase_9_N PF15420.6 CDW52398.1 - 0.038 14.0 1.6 0.08 12.9 0.4 2.1 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus UQ_con PF00179.26 CDW52399.1 - 9e-30 103.2 0.0 1.1e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDW52399.1 - 0.027 14.8 0.0 0.064 13.5 0.0 1.7 1 1 1 2 2 2 0 RWD domain Prok-E2_B PF14461.6 CDW52399.1 - 0.044 13.5 0.2 0.16 11.7 0.2 1.9 1 1 0 1 1 1 0 Prokaryotic E2 family B Tctex-1 PF03645.13 CDW52401.1 - 7.7e-19 67.9 0.7 6.8e-18 64.8 0.7 1.9 1 1 0 1 1 1 1 Tctex-1 family Scs3p PF10261.9 CDW52402.1 - 2.5e-26 92.7 15.6 8.3e-25 87.7 15.6 2.1 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 CDW52402.1 - 0.0015 18.3 8.4 0.029 14.1 8.4 2.7 1 1 0 1 1 1 1 PAP2 superfamily SUZ PF12752.7 CDW52403.1 - 4.2e-07 30.6 0.0 1e-06 29.4 0.0 1.7 1 0 0 1 1 1 1 SUZ domain 7tm_2 PF00002.24 CDW52404.1 - 7.1e-50 169.6 30.0 1.2e-49 168.8 30.0 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GPS PF01825.21 CDW52404.1 - 6.5e-14 52.2 4.7 1e-13 51.5 2.9 2.5 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Lectin_C PF00059.21 CDW52404.1 - 2e-13 51.0 11.8 9.7e-08 32.7 0.6 4.1 4 0 0 4 4 4 2 Lectin C-type domain GAIN PF16489.5 CDW52404.1 - 3.5e-12 46.2 6.6 1.5e-09 37.6 6.6 2.4 1 1 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.18 CDW52404.1 - 9.6e-09 35.6 0.1 4e-08 33.6 0.1 2.1 1 0 0 1 1 1 1 Galactose binding lectin domain HRM PF02793.22 CDW52404.1 - 0.00012 22.3 1.3 0.00012 22.3 1.3 2.8 2 0 0 2 2 2 1 Hormone receptor domain Dicty_CAR PF05462.11 CDW52404.1 - 0.013 14.7 17.2 0.036 13.2 17.2 1.7 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor MFS_1 PF07690.16 CDW52405.1 - 1.1e-31 110.1 40.9 1.5e-30 106.4 31.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily C2 PF00168.30 CDW52407.1 - 2.1e-06 28.0 0.0 3.7e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain Cid2 PF09774.9 CDW52407.1 - 1.3 9.4 6.2 11 6.4 0.1 3.6 3 0 0 3 3 3 0 Caffeine-induced death protein 2 DUF1180 PF06679.12 CDW52408.1 - 7.7e-08 32.9 0.0 9.5e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) DUF2681 PF10883.8 CDW52408.1 - 0.077 13.4 0.2 0.12 12.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Fusion_F0 PF13044.6 CDW52408.1 - 0.096 11.3 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0, Isavirus Kelch_5 PF13854.6 CDW52409.1 - 1.8e-10 40.5 4.2 0.026 14.5 0.0 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 CDW52409.1 - 3e-08 33.6 9.2 0.88 10.0 0.1 6.1 5 1 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 CDW52409.1 - 1.9e-07 30.9 7.3 0.39 10.8 0.1 6.0 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 CDW52409.1 - 1.8e-06 28.0 3.0 0.14 12.5 0.0 4.9 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 CDW52409.1 - 0.0037 16.8 4.3 0.29 10.7 0.1 5.0 6 1 0 6 6 6 1 Kelch motif Kelch_2 PF07646.15 CDW52409.1 - 0.02 14.9 5.9 11 6.2 0.0 5.5 7 0 0 7 7 7 0 Kelch motif Laminin_EGF PF00053.24 CDW52410.1 - 2.1e-53 178.2 551.3 0.0023 18.0 13.2 31.8 9 8 21 30 30 30 22 Laminin EGF domain FXa_inhibition PF14670.6 CDW52410.1 - 5.5e-30 103.4 77.7 2.6e-10 40.4 10.7 36.2 11 3 12 23 23 23 5 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW52410.1 - 3.2e-19 68.5 30.4 2.9e-08 33.5 2.1 38.3 39 7 1 40 40 40 8 Complement Clr-like EGF-like EGF_CA PF07645.15 CDW52410.1 - 1.5e-16 60.3 57.5 2.6e-07 30.7 9.7 32.0 20 8 10 30 30 30 5 Calcium-binding EGF domain hEGF PF12661.7 CDW52410.1 - 1.6e-07 31.7 61.5 5.9e-05 23.5 5.5 37.8 35 4 1 36 36 36 20 Human growth factor-like EGF EGF PF00008.27 CDW52410.1 - 0.00028 21.1 42.8 0.00041 20.6 6.1 38.1 39 3 0 39 39 39 19 EGF-like domain EGF_2 PF07974.13 CDW52410.1 - 0.00082 19.7 24.6 0.0033 17.7 13.0 45.4 37 13 4 41 41 41 17 EGF-like domain EGF_3 PF12947.7 CDW52410.1 - 0.0033 17.6 2.6 0.0033 17.6 2.6 31.1 27 4 2 29 29 29 4 EGF domain R3H-assoc PF13902.6 CDW52411.1 - 2.7e-11 44.0 0.0 5.6e-11 43.0 0.0 1.4 1 1 0 1 1 1 1 R3H-associated N-terminal domain Rootletin PF15035.6 CDW52412.1 - 4.4e-07 30.1 3.4 4.4e-07 30.1 3.4 8.8 2 1 6 8 8 8 1 Ciliary rootlet component, centrosome cohesion Sas6_CC PF18594.1 CDW52412.1 - 0.01 15.6 1.2 0.01 15.6 1.2 6.5 6 0 0 6 6 6 0 Sas6/XLF/XRCC4 coiled-coil domain Ribosomal_60s PF00428.19 CDW52412.1 - 8.5 7.0 12.9 5.1 7.7 0.2 4.1 4 0 0 4 4 4 0 60s Acidic ribosomal protein Sin3a_C PF16879.5 CDW52413.1 - 1e-31 110.7 6.6 1e-31 110.7 6.6 2.7 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 CDW52413.1 - 2.6e-25 88.4 0.0 1.4e-24 86.0 0.0 2.4 2 0 0 2 2 2 1 Sin3 family co-repressor PAH PF02671.21 CDW52413.1 - 9.9e-25 86.4 7.4 6.6e-16 58.2 1.0 3.5 3 0 0 3 3 3 2 Paired amphipathic helix repeat Sporozoite_P67 PF05642.11 CDW52413.1 - 0.00035 18.8 9.7 0.00035 18.8 9.7 2.9 3 0 0 3 3 3 1 Sporozoite P67 surface antigen SSP160 PF06933.11 CDW52413.1 - 0.077 11.2 16.6 0.13 10.5 16.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 COX5A PF02284.16 CDW52413.1 - 0.099 12.7 0.1 5.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Va CLTH PF10607.9 CDW52414.1 - 1.7e-29 102.6 1.2 3.2e-29 101.7 1.2 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain TEX13 PF15186.6 CDW52414.1 - 0.7 9.6 4.1 0.2 11.3 0.4 1.9 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family Histone PF00125.24 CDW52415.1 - 1.9e-20 73.5 0.4 2.2e-20 73.3 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW52415.1 - 9.2e-06 25.9 0.1 1.8e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW52415.1 - 0.04 14.1 0.1 0.068 13.3 0.1 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) TFIID_20kDa PF03847.13 CDW52415.1 - 0.061 13.8 0.0 0.089 13.3 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A CENP-T_C PF15511.6 CDW52415.1 - 0.085 13.0 0.3 0.23 11.6 0.2 1.7 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Histone_H2A_C PF16211.5 CDW52416.1 - 9.4e-05 22.1 0.1 0.00014 21.5 0.1 1.2 1 0 0 1 1 1 1 C-terminus of histone H2A Kunitz_BPTI PF00014.23 CDW52417.1 - 3.2e-10 40.1 1.1 3.2e-10 40.1 1.1 2.1 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain DUF1759 PF03564.15 CDW52418.1 - 0.015 15.2 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) MALT1_Ig PF18703.1 CDW52418.1 - 0.087 12.8 0.1 0.13 12.2 0.1 1.4 1 1 0 1 1 1 0 MALT1 Ig-like domain ZapB PF06005.12 CDW52419.1 - 0.0026 18.1 2.7 0.0026 18.1 2.7 8.3 4 2 2 6 6 6 1 Cell division protein ZapB bZIP_1 PF00170.21 CDW52419.1 - 0.016 15.3 2.2 0.016 15.3 2.2 9.3 6 2 4 10 10 10 0 bZIP transcription factor Pox_A_type_inc PF04508.12 CDW52419.1 - 0.016 15.0 13.8 0.4 10.6 0.6 5.1 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat AalphaY_MDB PF04611.12 CDW52419.1 - 0.091 12.8 0.9 3.8 7.5 0.1 2.9 2 0 0 2 2 2 0 Mating type protein A alpha Y mating type dependent binding region UCR_hinge PF02320.16 CDW52419.1 - 0.18 12.0 10.4 0.12 12.6 1.0 3.7 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase hinge protein Nbs1_C PF08599.10 CDW52419.1 - 0.37 10.9 3.2 0.65 10.2 0.6 2.9 2 0 0 2 2 2 0 DNA damage repair protein Nbs1 TolA_bind_tri PF16331.5 CDW52419.1 - 1.7 8.8 44.4 0.038 14.1 6.6 7.1 4 1 3 7 7 7 0 TolA binding protein trimerisation GAS PF13851.6 CDW52419.1 - 1.7 7.9 79.9 0.094 12.1 12.4 6.3 3 2 2 5 5 5 0 Growth-arrest specific micro-tubule binding TSC22 PF01166.18 CDW52419.1 - 2 8.8 28.5 0.7 10.2 0.6 6.8 5 2 2 7 7 7 0 TSC-22/dip/bun family TBP PF00352.21 CDW52420.1 - 4.3e-31 106.7 0.7 2.2e-14 53.1 0.0 3.3 3 1 0 3 3 3 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CDW52420.1 - 0.0016 18.5 0.0 0.09 12.9 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3378) GMP_PDE_delta PF05351.11 CDW52421.1 - 1.4e-30 106.4 0.1 2.1e-29 102.6 0.1 2.2 1 1 0 1 1 1 1 GMP-PDE, delta subunit Homeodomain PF00046.29 CDW52422.1 - 1e-22 79.7 4.1 1.7e-22 79.0 4.1 1.3 1 0 0 1 1 1 1 Homeodomain RRF PF01765.19 CDW52424.1 - 6.8e-29 100.9 0.6 6.8e-29 100.9 0.6 1.4 1 1 0 1 1 1 1 Ribosome recycling factor Mst1_SARAH PF11629.8 CDW52424.1 - 0.46 10.6 5.4 0.46 10.6 1.8 2.4 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 zf-C2H2_4 PF13894.6 CDW52425.1 - 0.037 14.9 2.7 0.07 14.0 2.7 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW52425.1 - 3.4 8.3 5.5 13 6.4 0.7 2.3 2 0 0 2 2 2 0 Zinc-finger double domain SH3BGR PF04908.15 CDW52426.1 - 1.9e-15 56.8 0.0 5.5e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein TNFR_c6 PF00020.18 CDW52427.1 - 1.7e-27 95.6 52.3 5.4e-08 33.1 5.8 4.5 4 0 0 4 4 4 4 TNFR/NGFR cysteine-rich region TNFR_16_TM PF18422.1 CDW52427.1 - 0.0021 18.0 1.9 0.0049 16.8 1.9 1.6 1 0 0 1 1 1 1 Tumor necrosis factor receptor member 16 trans-membrane domain PDCD9 PF07147.12 CDW52429.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S30 (PDCD9) EGF_2 PF07974.13 CDW52430.1 - 0.00034 20.9 27.4 0.011 16.0 2.4 3.4 3 0 0 3 3 3 3 EGF-like domain EGF_Tenascin PF18720.1 CDW52430.1 - 0.1 12.7 0.8 0.1 12.7 0.8 3.5 4 0 0 4 4 4 0 Tenascin EGF domain TMEM52 PF14979.6 CDW52430.1 - 2.1 8.2 8.1 12 5.8 8.1 2.0 1 1 0 1 1 1 0 Transmembrane 52 RhoGAP PF00620.27 CDW52431.1 - 4.4e-18 65.6 0.0 6e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Ank_2 PF12796.7 CDW52433.1 - 3.2e-38 130.2 10.3 4.1e-17 62.5 0.8 3.0 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW52433.1 - 1.4e-28 98.9 11.1 1.2e-10 41.7 0.1 4.3 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 CDW52433.1 - 2.4e-22 78.3 6.7 2.4e-05 24.6 0.5 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 CDW52433.1 - 1.5e-21 76.2 7.2 9.1e-08 32.2 0.4 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW52433.1 - 1.3e-19 68.2 5.0 0.00022 21.4 0.5 5.6 6 0 0 6 6 6 4 Ankyrin repeat SOCS_box PF07525.16 CDW52433.1 - 2.7e-08 34.0 5.2 6.3e-08 32.8 5.2 1.6 1 0 0 1 1 1 1 SOCS box Peptidase_M14 PF00246.24 CDW52434.1 - 1.6e-11 44.5 0.0 2.8e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase UNC45-central PF11701.8 CDW52434.1 - 0.019 14.9 0.3 0.052 13.5 0.3 1.8 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central zf-TAZ PF02135.16 CDW52435.1 - 4.7e-15 55.8 13.6 5.9e-15 55.5 13.6 1.1 1 0 0 1 1 1 1 TAZ zinc finger RRM_1 PF00076.22 CDW52437.1 - 8.8e-10 38.3 0.4 0.00015 21.5 0.2 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 CDW52437.1 - 0.0022 18.2 0.0 3.7 7.8 0.0 2.7 2 0 0 2 2 2 2 BRCA1-associated protein 2 Calx-beta PF03160.14 CDW52437.1 - 0.0077 16.4 0.3 7.2 6.8 0.2 2.6 2 0 0 2 2 2 2 Calx-beta domain zf-RanBP PF00641.18 CDW52437.1 - 0.03 13.6 18.9 0.044 13.1 5.8 2.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others Dishevelled PF02377.15 CDW52439.1 - 7.4e-24 85.0 18.6 1e-23 84.6 15.5 2.2 2 0 0 2 2 2 1 Dishevelled specific domain PDZ PF00595.24 CDW52439.1 - 3.1e-18 65.9 0.2 6.1e-18 65.0 0.2 1.4 1 0 0 1 1 1 1 PDZ domain DEP PF00610.21 CDW52439.1 - 6.5e-16 58.1 0.1 1.4e-15 57.1 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 CDW52439.1 - 1.7e-05 24.5 0.0 3.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW52439.1 - 0.011 16.0 0.1 0.027 14.8 0.1 1.7 1 0 0 1 1 1 0 PDZ domain PB1 PF00564.24 CDW52440.1 - 1.4e-11 44.2 0.8 2.7e-11 43.2 0.8 1.5 1 0 0 1 1 1 1 PB1 domain 3HCDH_N PF02737.18 CDW52441.1 - 4.7e-52 176.5 0.8 4.7e-52 176.5 0.8 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 CDW52441.1 - 2.1e-35 122.3 0.0 3.7e-35 121.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 CDW52441.1 - 2.7e-30 104.8 0.1 4.5e-22 78.5 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 CDW52441.1 - 7.6e-23 81.5 0.1 1.3e-22 80.8 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NAD_Gly3P_dh_N PF01210.23 CDW52441.1 - 0.043 13.8 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus RBD PF02196.15 CDW52441.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Raf-like Ras-binding domain Ribosomal_L19 PF01245.20 CDW52442.1 - 1.6e-14 53.8 0.0 2.4e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L19 Not1 PF04054.15 CDW52443.1 - 1.7e-125 418.8 0.0 4.1e-125 417.5 0.0 1.7 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 CDW52443.1 - 1.3e-75 253.6 2.6 2.9e-75 252.5 2.6 1.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 CDW52443.1 - 6e-48 162.5 0.0 1.4e-47 161.4 0.0 1.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 CDW52443.1 - 1.3e-30 106.2 0.4 5e-30 104.4 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 CDW52443.1 - 1.9e-19 70.2 0.1 4.6e-19 69.0 0.1 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat Not1 PF04054.15 CDW52444.1 - 2.4e-119 398.6 1.1 5e-119 397.5 0.0 2.1 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 CDW52444.1 - 7.8e-75 251.1 7.7 7.8e-75 251.1 7.7 2.0 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 CDW52444.1 - 1.2e-38 132.2 0.0 2.9e-38 131.0 0.0 1.6 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 CDW52444.1 - 1.4e-26 93.2 1.1 4.7e-26 91.5 1.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 CDW52444.1 - 2.6e-16 60.0 0.1 8.9e-16 58.3 0.1 2.0 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF3530 PF12048.8 CDW52444.1 - 0.27 10.6 1.0 0.47 9.8 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) TUDOR PF00567.24 CDW52445.1 - 0.0011 19.0 0.0 0.0042 17.1 0.0 1.8 2 0 0 2 2 2 1 Tudor domain ketoacyl-synt PF00109.26 CDW52447.1 - 1.3e-53 182.2 3.6 3.4e-52 177.5 0.2 2.2 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CDW52447.1 - 4.2e-35 120.3 0.6 1e-34 119.0 0.2 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CDW52447.1 - 0.0063 15.9 0.4 0.039 13.3 0.2 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain DENN PF02141.21 CDW52450.1 - 1.9e-41 142.1 3.7 3.8e-41 141.1 3.7 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 CDW52450.1 - 4.6e-17 61.7 1.4 4.6e-17 61.7 1.4 2.2 2 0 0 2 2 2 1 dDENN domain RUN PF02759.19 CDW52450.1 - 1.6e-12 47.5 4.1 1.4e-09 38.0 0.1 3.2 3 0 0 3 3 3 2 RUN domain uDENN PF03456.18 CDW52450.1 - 3e-11 43.9 0.1 1.1e-10 42.1 0.1 2.1 1 0 0 1 1 1 1 uDENN domain PLAT PF01477.23 CDW52450.1 - 0.00027 21.5 0.0 0.00082 19.9 0.0 1.8 2 0 0 2 2 2 1 PLAT/LH2 domain Tetraspanin PF00335.20 CDW52451.1 - 2.7e-05 24.0 14.4 2.7e-05 24.0 14.4 1.8 1 1 0 1 1 1 1 Tetraspanin family DUF3112 PF11309.8 CDW52451.1 - 0.018 14.5 0.2 0.03 13.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) CTP_transf_1 PF01148.20 CDW52451.1 - 0.072 12.9 0.4 0.11 12.3 0.4 1.3 1 0 0 1 1 1 0 Cytidylyltransferase family RRM_1 PF00076.22 CDW52452.1 - 7.4e-10 38.5 0.1 0.002 17.9 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LCAT PF02450.15 CDW52453.1 - 6.2e-79 266.0 2.8 2.5e-77 260.7 2.8 2.0 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF915 PF06028.11 CDW52453.1 - 6.4e-05 22.4 0.5 0.29 10.4 0.5 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 CDW52453.1 - 0.0067 16.0 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 CDW52453.1 - 0.065 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Palm_thioest PF02089.15 CDW52453.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Neur_chan_LBD PF02931.23 CDW52454.1 - 2.8e-45 154.4 0.1 9.4e-45 152.7 0.2 1.7 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW52454.1 - 3.8e-26 92.6 2.2 6.7e-24 85.3 2.2 2.2 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF3808 PF10300.9 CDW52455.1 - 4.3e-124 414.8 9.3 5.4e-124 414.5 9.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_8 PF13181.6 CDW52455.1 - 0.0051 16.9 0.2 8.5 6.9 0.1 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF416 PF04222.12 CDW52455.1 - 0.013 15.0 0.1 0.026 14.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF416) TPR_14 PF13428.6 CDW52455.1 - 0.045 14.6 1.0 36 5.5 0.0 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat UBA_4 PF14555.6 CDW52455.1 - 0.084 12.7 0.4 2.3 8.1 0.0 3.0 2 0 0 2 2 2 0 UBA-like domain TPR_16 PF13432.6 CDW52455.1 - 0.12 13.0 4.2 0.93 10.2 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Sec61_beta PF03911.16 CDW52456.1 - 1.7e-20 72.7 0.3 2.4e-20 72.3 0.3 1.2 1 0 0 1 1 1 1 Sec61beta family LSM_int_assoc PF16605.5 CDW52456.1 - 0.2 11.8 0.0 0.27 11.4 0.0 1.2 1 0 0 1 1 1 0 LSM-interacting associated unstructured adh_short_C2 PF13561.6 CDW52457.1 - 3.6e-52 177.3 0.0 6.4e-40 137.2 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDW52457.1 - 1.1e-43 149.0 0.0 1.5e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDW52457.1 - 5.3e-16 59.0 0.0 7.7e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 KR domain 2-Hacid_dh_C PF02826.19 CDW52457.1 - 0.021 14.2 0.0 0.048 13.0 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 CDW52457.1 - 0.034 13.3 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein Homeodomain PF00046.29 CDW52459.1 - 1.4e-16 60.1 15.3 1.4e-13 50.4 1.2 2.5 2 0 0 2 2 2 2 Homeodomain Ric8 PF10165.9 CDW52460.1 - 2.4e-58 198.3 0.0 2.9e-58 198.0 0.0 1.1 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Ion_trans PF00520.31 CDW52461.1 - 8.9e-40 136.5 19.3 1.2e-39 136.0 19.3 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 CDW52461.1 - 6.9e-29 100.0 0.0 1.7e-28 98.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 CDW52461.1 - 2.2e-11 43.5 2.4 2.2e-11 43.5 2.4 2.6 3 0 0 3 3 3 1 Ion channel BTB_3 PF16017.5 CDW52461.1 - 0.038 14.1 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 BTB/POZ domain Peptidase_M9 PF01752.17 CDW52461.1 - 0.052 12.8 0.1 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 Collagenase PKD_channel PF08016.12 CDW52461.1 - 0.23 10.1 9.2 0.36 9.5 1.0 2.3 1 1 1 2 2 2 0 Polycystin cation channel DUF21 PF01595.20 CDW52462.1 - 9.3e-05 22.2 0.0 0.00012 21.8 0.0 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain HEAT PF02985.22 CDW52463.1 - 4.8e-06 26.4 3.8 0.92 9.9 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 CDW52463.1 - 0.023 15.1 0.1 22 5.5 0.0 4.7 4 1 1 5 5 5 0 HEAT repeats Arm PF00514.23 CDW52463.1 - 0.067 13.3 0.2 38 4.5 0.0 3.9 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat CDT1 PF08839.11 CDW52464.1 - 1.1e-36 126.8 3.3 2.5e-36 125.6 3.3 1.7 1 0 0 1 1 1 1 DNA replication factor CDT1 like CDT1_C PF16679.5 CDW52464.1 - 6.7e-08 32.9 0.2 6.7e-08 32.9 0.2 2.0 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain Prefoldin PF02996.17 CDW52465.1 - 4.3e-10 39.5 0.1 4.3e-10 39.5 0.1 2.6 4 0 0 4 4 4 1 Prefoldin subunit Prefoldin_2 PF01920.20 CDW52465.1 - 0.051 13.5 0.1 0.051 13.5 0.1 2.8 3 0 0 3 3 3 0 Prefoldin subunit zf-MYND PF01753.18 CDW52466.1 - 7.3e-06 26.0 13.1 7.3e-06 26.0 13.1 2.6 3 0 0 3 3 3 1 MYND finger dsrm PF00035.26 CDW52467.1 - 7.2e-11 42.6 0.0 0.0002 22.0 0.0 2.3 2 0 0 2 2 2 2 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CDW52467.1 - 0.00015 22.0 0.4 0.0066 16.7 0.1 2.6 2 1 0 2 2 2 1 double strand RNA binding domain from DEAD END PROTEIN 1 Myelin_PLP PF01275.19 CDW52468.1 - 1.4e-46 159.3 16.8 1.7e-46 159.0 16.8 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) SAC3_GANP PF03399.16 CDW52469.1 - 1.1e-71 241.6 0.4 1.8e-71 240.9 0.4 1.3 1 0 0 1 1 1 1 SAC3/GANP family HECT PF00632.25 CDW52471.1 - 7.8e-100 334.3 0.1 1e-99 333.9 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 CDW52471.1 - 1.7e-25 88.8 9.7 3.8e-13 49.3 0.9 3.9 3 0 0 3 3 3 3 WW domain C2 PF00168.30 CDW52471.1 - 1.7e-09 37.9 0.0 3.8e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain ThuA PF06283.11 CDW52471.1 - 0.053 13.7 0.1 0.22 11.7 0.0 2.0 3 0 0 3 3 3 0 Trehalose utilisation CNH PF00780.22 CDW52473.1 - 2e-56 191.6 0.0 3e-56 191.0 0.0 1.3 1 0 0 1 1 1 1 CNH domain Pkinase PF00069.25 CDW52473.1 - 2.5e-55 187.7 0.1 3.4e-54 184.0 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52473.1 - 3.8e-40 137.8 0.2 5.6e-39 134.0 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW52473.1 - 0.00093 18.6 0.1 0.0017 17.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW52473.1 - 0.0041 16.0 0.0 0.021 13.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 CDW52473.1 - 0.056 13.1 0.1 0.41 10.2 0.0 2.0 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 CDW52473.1 - 0.066 12.5 0.1 0.19 11.0 0.1 1.7 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 CDW52473.1 - 0.14 12.1 0.1 0.5 10.2 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DAGAT PF03982.13 CDW52474.1 - 7.4e-86 287.7 1.7 8.1e-43 146.4 1.0 3.0 2 1 0 2 2 2 2 Diacylglycerol acyltransferase Myb_DNA-binding PF00249.31 CDW52475.1 - 1.8e-05 24.9 0.3 4.9e-05 23.4 0.3 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDW52475.1 - 0.0003 21.0 2.5 0.00078 19.6 0.1 2.7 2 1 1 3 3 3 1 Myb-like DNA-binding domain ZZ PF00569.17 CDW52475.1 - 0.087 12.7 10.9 0.24 11.3 10.9 1.8 1 0 0 1 1 1 0 Zinc finger, ZZ type Img2 PF05046.14 CDW52476.1 - 9.8e-20 70.6 0.0 2e-19 69.7 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial large subunit ribosomal protein (Img2) DUF4632 PF15451.6 CDW52476.1 - 0.14 12.2 0.2 0.3 11.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) Aldo_ket_red PF00248.21 CDW52477.1 - 4.1e-10 39.3 0.0 5.3e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Zw10 PF06248.13 CDW52477.1 - 0.091 11.3 0.1 0.13 10.8 0.1 1.1 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 SRCR PF00530.18 CDW52478.1 - 1.2e-43 147.7 8.1 1.1e-16 61.2 0.3 3.6 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Beta_helix PF13229.6 CDW52478.1 - 8.3e-12 45.2 46.5 6.8e-05 22.8 11.3 9.2 7 2 2 9 9 9 5 Right handed beta helix region SRCR_2 PF15494.6 CDW52478.1 - 1.9e-09 38.0 3.8 0.021 15.3 0.2 3.9 3 0 0 3 3 3 3 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 CDW52478.1 - 1.3e-06 28.9 0.5 0.52 10.8 0.0 3.6 3 0 0 3 3 3 3 Hepsin, SRCR domain Lectin_C PF00059.21 CDW52478.1 - 0.00037 21.2 0.0 0.0034 18.1 0.0 2.7 2 1 0 2 2 2 1 Lectin C-type domain DAN PF03045.15 CDW52479.1 - 0.00031 20.8 0.6 0.00042 20.3 0.6 1.4 1 0 0 1 1 1 1 DAN domain PAPS_reduct PF01507.19 CDW52480.1 - 5.5e-25 88.4 0.0 7e-23 81.5 0.0 2.2 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family DUF2451 PF10474.9 CDW52480.1 - 0.05 13.4 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) WAP PF00095.21 CDW52481.1 - 4.5e-12 46.1 22.6 3.8e-07 30.4 7.8 5.2 5 0 0 5 5 5 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' WAP PF00095.21 CDW52482.1 - 1e-54 182.6 71.1 1.7e-09 37.9 4.9 6.1 6 0 0 6 6 6 6 WAP-type (Whey Acidic Protein) 'four-disulfide core' Pkinase PF00069.25 CDW52483.1 - 2e-74 250.3 0.0 3e-74 249.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52483.1 - 1.2e-40 139.5 0.0 1.8e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 CDW52483.1 - 1.8e-13 51.0 0.1 7.1e-12 45.8 0.0 3.1 1 1 1 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 CDW52483.1 - 3e-06 26.8 0.0 4.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CDW52483.1 - 0.0012 18.4 0.1 0.0023 17.5 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CDW52483.1 - 0.12 12.2 1.0 0.36 10.7 0.8 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CDW52483.1 - 0.13 11.6 0.1 0.21 10.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aminotran_1_2 PF00155.21 CDW52485.1 - 1.9e-46 158.9 0.0 1.5e-43 149.4 0.0 2.0 1 1 1 2 2 2 2 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDW52485.1 - 0.0002 20.8 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CDW52485.1 - 0.052 12.5 0.0 0.079 11.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V DUF2517 PF10725.9 CDW52485.1 - 0.19 11.5 1.6 0.32 10.8 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2517) PX PF00787.24 CDW52486.1 - 7.1e-12 45.3 0.2 7.1e-12 45.3 0.2 2.7 3 0 0 3 3 3 2 PX domain Vps5 PF09325.10 CDW52486.1 - 9.1e-06 25.4 3.2 9.1e-06 25.4 3.2 3.0 2 1 2 4 4 4 2 Vps5 C terminal like PAX PF00292.18 CDW52487.1 - 1.3e-59 199.5 0.7 1.6e-59 199.3 0.7 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 CDW52487.1 - 4.2e-07 29.6 0.0 2.2e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 Homeodomain-like domain HTH_32 PF13565.6 CDW52487.1 - 6.2e-06 26.7 0.2 4.3e-05 24.0 0.0 2.0 1 1 1 2 2 2 1 Homeodomain-like domain MarR_2 PF12802.7 CDW52487.1 - 0.0065 16.3 0.1 0.025 14.4 0.0 2.1 1 1 1 2 2 2 1 MarR family HTH_38 PF13936.6 CDW52487.1 - 0.019 14.7 3.0 0.7 9.7 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_29 PF13551.6 CDW52487.1 - 0.039 14.0 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix HTH_28 PF13518.6 CDW52487.1 - 0.051 13.7 0.0 0.096 12.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_5 PF01022.20 CDW52487.1 - 0.21 11.5 3.5 5.4 7.0 0.3 3.3 3 1 0 3 3 3 0 Bacterial regulatory protein, arsR family RRM_1 PF00076.22 CDW52488.1 - 3.2e-12 46.1 0.0 5.8e-12 45.3 0.0 1.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDW52488.1 - 3.7e-05 23.6 0.1 9.4e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif TRAP_alpha PF03896.16 CDW52489.1 - 2.9e-78 262.9 0.2 3.3e-78 262.8 0.2 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Orf78 PF06024.12 CDW52489.1 - 0.027 14.8 0.7 0.072 13.4 0.7 1.7 1 0 0 1 1 1 0 Orf78 (ac78) DUF4579 PF15158.6 CDW52489.1 - 0.052 13.3 0.7 0.084 12.6 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4579) SPT_ssu-like PF11779.8 CDW52489.1 - 0.9 9.2 3.8 0.78 9.4 0.6 2.2 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like DUF5330 PF17264.2 CDW52490.1 - 0.031 14.3 0.2 0.056 13.5 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5330) Ins134_P3_kin PF05770.11 CDW52491.1 - 3.5e-41 140.9 0.1 2e-40 138.4 0.0 1.9 2 0 0 2 2 2 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 CDW52491.1 - 3.6e-16 59.3 2.4 6.1e-16 58.6 0.3 2.4 2 1 1 3 3 3 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain TTL PF03133.15 CDW52491.1 - 0.04 13.1 0.0 0.089 11.9 0.0 1.6 1 0 0 1 1 1 0 Tubulin-tyrosine ligase family HSP20 PF00011.21 CDW52492.1 - 1.2e-16 60.7 0.2 1.8e-16 60.2 0.2 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW52492.1 - 1.2e-06 27.9 0.0 2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Sterol-sensing PF12349.8 CDW52493.1 - 2.2e-08 34.1 10.5 2.2e-08 34.1 10.5 3.1 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CDW52493.1 - 3.8e-07 28.6 11.1 3.8e-07 28.6 11.1 2.6 2 1 0 2 2 2 2 Patched family MMPL PF03176.15 CDW52493.1 - 8.4e-06 24.9 3.1 8.4e-06 24.9 3.1 2.2 2 0 0 2 2 2 2 MMPL family MFS_1 PF07690.16 CDW52494.1 - 8.7e-20 70.9 14.0 8.7e-20 70.9 14.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily LRR_8 PF13855.6 CDW52495.1 - 1.9e-33 114.0 30.2 1.2e-12 47.4 1.4 6.0 2 2 5 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 CDW52495.1 - 4.3e-17 61.9 31.7 1.3e-06 28.6 0.1 7.1 4 2 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW52495.1 - 1.9e-12 47.2 3.2 1.2e-06 28.5 0.0 4.3 2 2 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CDW52495.1 - 8.3e-09 34.8 17.5 0.63 10.8 0.0 8.2 8 0 0 8 8 8 4 Leucine Rich Repeat LRR_9 PF14580.6 CDW52495.1 - 0.00084 18.9 11.0 0.048 13.2 1.5 3.4 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 CDW52495.1 - 0.00085 19.2 17.3 0.6 10.3 0.2 7.2 7 0 0 7 7 7 2 Leucine Rich repeat Phasin_2 PF09361.10 CDW52496.1 - 0.0018 18.5 1.4 0.23 11.7 0.1 3.3 1 1 1 2 2 2 1 Phasin protein Yuri_gagarin PF15934.5 CDW52496.1 - 0.0022 17.9 3.5 0.0046 16.8 1.9 1.9 1 1 1 2 2 2 1 Yuri gagarin Baculo_PEP_C PF04513.12 CDW52496.1 - 0.0049 16.9 2.0 0.047 13.7 2.0 2.2 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus DegS PF05384.11 CDW52496.1 - 0.0058 16.1 1.1 0.02 14.4 0.2 1.9 1 1 1 2 2 2 1 Sensor protein DegS DUF948 PF06103.11 CDW52496.1 - 0.0083 16.4 0.4 0.09 13.0 0.4 2.1 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Med2 PF11214.8 CDW52496.1 - 0.0089 16.2 3.2 0.026 14.7 1.6 2.0 1 1 1 2 2 2 1 Mediator complex subunit 2 DUF148 PF02520.17 CDW52496.1 - 0.016 15.3 2.8 0.019 15.1 0.9 2.1 1 1 1 2 2 2 0 Domain of unknown function DUF148 Sec5 PF15469.6 CDW52496.1 - 0.019 14.8 5.0 0.11 12.3 2.6 2.2 1 1 1 2 2 2 0 Exocyst complex component Sec5 WXG100 PF06013.12 CDW52496.1 - 0.023 14.9 3.9 0.19 12.0 0.1 3.0 1 1 2 3 3 3 0 Proteins of 100 residues with WXG Tmemb_cc2 PF10267.9 CDW52496.1 - 0.027 13.6 4.0 0.034 13.3 4.0 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein FYRC PF05965.14 CDW52496.1 - 0.031 14.4 0.1 0.079 13.1 0.1 1.8 1 1 0 1 1 1 0 F/Y rich C-terminus Prominin PF05478.11 CDW52496.1 - 0.062 11.3 3.4 0.17 9.8 3.4 1.5 1 1 0 1 1 1 0 Prominin P4Ha_N PF08336.11 CDW52496.1 - 0.096 12.7 4.0 0.072 13.1 1.3 2.0 2 1 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF2120 PF09893.9 CDW52496.1 - 0.097 12.8 1.0 0.21 11.7 1.0 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) Ribosomal_L21e PF01157.18 CDW52496.1 - 0.11 12.4 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein L21e NPV_P10 PF05531.12 CDW52496.1 - 0.12 12.9 0.6 1.4 9.5 0.1 2.4 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ApoO PF09769.9 CDW52496.1 - 0.28 11.1 2.2 14 5.6 0.2 2.5 1 1 0 2 2 2 0 Apolipoprotein O Fib_alpha PF08702.10 CDW52496.1 - 0.86 9.8 6.5 6.8 6.9 4.1 2.2 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4298 PF14131.6 CDW52496.1 - 1.3 9.0 6.0 7.2 6.6 0.1 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4298) DUF273 PF03314.14 CDW52497.1 - 1.1e-41 142.9 4.4 1.4e-41 142.4 4.4 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF273 Glyco_transf_34 PF05637.12 CDW52497.1 - 1.5e-05 24.9 0.1 0.0015 18.3 0.0 2.2 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family DUF3437 PF11919.8 CDW52498.1 - 1.3e-31 108.3 0.0 1.1e-30 105.4 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) HEAT PF02985.22 CDW52498.1 - 0.012 15.8 0.1 0.045 14.0 0.1 2.1 1 0 0 1 1 1 0 HEAT repeat HEAT_EZ PF13513.6 CDW52498.1 - 0.071 13.6 0.0 20 5.8 0.0 2.6 2 0 0 2 2 2 0 HEAT-like repeat RICTOR_N PF14664.6 CDW52498.1 - 0.15 11.0 0.8 0.37 9.7 0.8 1.8 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term MBD PF01429.19 CDW52499.1 - 8.4e-09 35.0 0.0 1.4e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Methyl-CpG binding domain Vert_HS_TF PF06546.11 CDW52499.1 - 0.0059 16.3 0.4 0.0074 16.0 0.4 1.1 1 0 0 1 1 1 1 Vertebrate heat shock transcription factor LRV_FeS PF05484.11 CDW52499.1 - 0.021 14.8 0.0 0.053 13.5 0.0 1.7 1 0 0 1 1 1 0 LRV protein FeS4 cluster Inositol_P PF00459.25 CDW52500.1 - 3.5e-77 259.6 0.0 4.1e-77 259.4 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 CDW52500.1 - 0.019 14.5 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain HSP90 PF00183.18 CDW52501.1 - 6e-210 698.5 18.3 6e-210 698.5 18.3 2.5 2 1 1 3 3 3 1 Hsp90 protein HATPase_c PF02518.26 CDW52501.1 - 2.4e-12 47.4 0.1 4e-12 46.6 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDW52501.1 - 2.8e-08 33.7 0.0 8.1e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Peptidase_A22B PF04258.13 CDW52502.1 - 1.9e-71 240.9 12.7 3.9e-71 239.9 12.7 1.4 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 CDW52502.1 - 2.8e-09 36.9 8.2 2.8e-09 36.9 8.2 1.8 2 0 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease Presenilin PF01080.17 CDW52502.1 - 0.59 8.8 7.2 0.082 11.7 2.1 2.0 1 1 0 2 2 2 0 Presenilin GDI PF00996.18 CDW52503.1 - 5e-219 727.2 0.0 5.7e-219 727.0 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor TILa PF12714.7 CDW52503.1 - 0.081 12.9 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 TILa domain PAX PF00292.18 CDW52505.1 - 4.4e-31 107.4 0.4 9.8e-31 106.3 0.4 1.6 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 CDW52505.1 - 4.4e-19 68.1 4.2 7.8e-19 67.3 4.2 1.4 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 CDW52505.1 - 5e-07 29.3 0.0 1.3e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain Homeobox_KN PF05920.11 CDW52505.1 - 3.2e-06 26.9 1.8 6.1e-06 26.0 0.4 2.2 3 0 0 3 3 3 1 Homeobox KN domain HTH_28 PF13518.6 CDW52505.1 - 0.00018 21.6 0.5 0.0011 19.1 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_29 PF13551.6 CDW52505.1 - 0.0045 17.0 0.1 0.0087 16.1 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_32 PF13565.6 CDW52505.1 - 0.48 11.1 3.1 2.2 9.0 0.1 2.8 2 1 1 3 3 3 0 Homeodomain-like domain Ribosomal_L23 PF00276.20 CDW52506.1 - 7.1e-09 35.9 0.2 7.1e-09 35.9 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L23 SH3_14 PF18343.1 CDW52506.1 - 0.065 13.3 0.0 0.083 13.0 0.0 1.1 1 0 0 1 1 1 0 Dda helicase SH3 domain Peptidase_M20 PF01546.28 CDW52507.1 - 1.5e-27 96.7 0.0 2.1e-27 96.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDW52507.1 - 1.1e-05 25.3 0.0 2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CDW52507.1 - 0.0011 18.7 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 VHL_C PF17211.3 CDW52507.1 - 0.029 14.4 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 VHL box domain Amidohydro_1 PF01979.20 CDW52508.1 - 5.1e-22 78.6 0.0 2.5e-11 43.5 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 CDW52508.1 - 4.2e-07 29.8 0.1 0.0013 18.2 0.0 3.0 2 1 1 3 3 3 3 Amidohydrolase family WD40 PF00400.32 CDW52509.1 - 7e-42 140.6 16.4 2.9e-07 31.1 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52509.1 - 2.6e-14 53.3 0.0 0.0036 17.6 0.1 5.5 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW52509.1 - 0.00013 21.9 0.0 0.84 9.5 0.0 2.9 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CDW52509.1 - 0.00048 19.5 0.0 0.042 13.2 0.0 2.6 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 CDW52509.1 - 0.0061 15.6 0.5 6.5 5.6 0.1 3.9 2 1 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Laminin_II PF06009.12 CDW52509.1 - 0.15 12.1 0.2 0.21 11.6 0.2 1.2 1 0 0 1 1 1 0 Laminin Domain II Cytochrom_D1 PF02239.16 CDW52509.1 - 0.17 10.4 0.0 0.6 8.6 0.0 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain Kinesin PF00225.23 CDW52510.1 - 2.2e-71 240.5 0.0 2.6e-69 233.7 0.0 2.0 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDW52510.1 - 7.7e-12 45.4 0.2 3.1e-09 36.9 0.0 2.7 1 1 1 2 2 2 2 Microtubule binding BPL_LplA_LipB PF03099.19 CDW52511.1 - 4.2e-07 29.9 0.0 8.4e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family HLH PF00010.26 CDW52512.1 - 9.5e-14 51.1 0.2 1.6e-13 50.4 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sybindin PF04099.12 CDW52512.1 - 0.039 13.9 0.1 0.053 13.4 0.1 1.1 1 0 0 1 1 1 0 Sybindin-like family ThiF PF00899.21 CDW52513.1 - 3.1e-96 321.5 0.0 3.4e-69 232.9 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 CDW52513.1 - 6.2e-88 295.0 0.1 9.9e-88 294.3 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 CDW52513.1 - 1.4e-34 118.7 0.1 2.9e-34 117.6 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 CDW52513.1 - 1.1e-26 92.8 0.3 2.6e-26 91.6 0.3 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 CDW52513.1 - 2e-23 82.3 0.1 6.2e-23 80.8 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Shikimate_DH PF01488.20 CDW52513.1 - 0.0048 17.0 0.1 2 8.5 0.0 2.7 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 CDW52513.1 - 0.062 12.5 0.0 0.27 10.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDW52513.1 - 0.4 11.3 2.0 0.72 10.5 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DivIC PF04977.15 CDW52515.1 - 0.011 15.5 0.3 0.029 14.1 0.3 1.7 1 0 0 1 1 1 0 Septum formation initiator APG6_N PF17675.1 CDW52515.1 - 0.011 16.3 0.9 0.22 12.1 0.2 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region MscS_porin PF12795.7 CDW52515.1 - 0.013 15.0 0.8 0.021 14.4 0.0 1.6 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain AJAP1_PANP_C PF15298.6 CDW52515.1 - 0.064 13.5 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Herpes_BLRF2 PF05812.12 CDW52515.1 - 0.073 13.2 1.5 0.28 11.3 1.1 2.0 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein LRRFIP PF09738.9 CDW52515.1 - 0.089 12.3 1.3 0.094 12.2 0.0 1.5 2 0 0 2 2 2 0 LRRFIP family Spc24 PF08286.11 CDW52515.1 - 0.18 12.0 1.0 0.47 10.7 0.1 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Prefoldin PF02996.17 CDW52515.1 - 0.21 11.5 2.3 6.8 6.6 0.3 2.4 2 0 0 2 2 2 0 Prefoldin subunit ZapB PF06005.12 CDW52515.1 - 0.24 11.9 7.0 0.23 11.9 1.0 2.8 3 0 0 3 3 3 0 Cell division protein ZapB CENP-F_leu_zip PF10473.9 CDW52515.1 - 0.45 10.5 4.2 0.15 12.1 0.6 1.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 M PF02370.16 CDW52515.1 - 0.7 10.6 3.1 2 9.3 3.1 1.8 1 0 0 1 1 1 0 M protein repeat bZIP_1 PF00170.21 CDW52515.1 - 0.75 9.9 4.9 0.26 11.4 1.0 2.1 2 0 0 2 2 2 0 bZIP transcription factor Mto2_bdg PF12808.7 CDW52515.1 - 2.3 8.6 6.4 0.34 11.3 1.7 2.1 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Prefoldin_2 PF01920.20 CDW52515.1 - 2.9 7.9 5.6 0.81 9.7 0.2 2.4 3 0 0 3 3 2 0 Prefoldin subunit FlaC_arch PF05377.11 CDW52515.1 - 4.3 7.8 4.7 0.83 10.1 0.3 2.1 3 0 0 3 3 1 0 Flagella accessory protein C (FlaC) bZIP_2 PF07716.15 CDW52515.1 - 5.3 7.2 6.8 1.5 9.0 2.6 2.0 2 0 0 2 2 2 0 Basic region leucine zipper Ion_trans PF00520.31 CDW52516.1 - 8.9e-248 817.6 96.2 1.4e-68 230.7 6.4 5.1 4 1 1 5 5 5 5 Ion transport protein GPHH PF16905.5 CDW52516.1 - 5.7e-28 96.4 1.0 1.2e-27 95.5 0.1 2.1 3 0 0 3 3 3 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.11 CDW52516.1 - 1.3e-26 92.6 0.0 3.6e-26 91.2 0.0 1.8 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain CAC1F_C PF16885.5 CDW52516.1 - 2.6e-10 40.5 0.0 2.1e-06 27.7 0.0 2.8 3 0 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term PKD_channel PF08016.12 CDW52516.1 - 2.8e-09 36.2 88.9 3.1e-05 22.8 19.7 9.0 7 2 2 9 9 9 6 Polycystin cation channel Sh_2 PF17512.2 CDW52516.1 - 0.14 11.9 0.4 0.53 10.0 0.4 2.0 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein Pkinase PF00069.25 CDW52518.1 - 2.2e-68 230.5 0.0 6.9e-68 228.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52518.1 - 2.5e-38 131.8 0.0 4.1e-38 131.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW52518.1 - 4.5e-06 25.9 0.1 1.2e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CDW52518.1 - 0.00065 19.1 0.1 0.0014 18.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Cystatin PF00031.21 CDW52519.1 - 2e-12 47.2 0.8 3.4e-12 46.4 0.8 1.3 1 0 0 1 1 1 1 Cystatin domain Cathelicidins PF00666.17 CDW52519.1 - 0.0027 18.0 0.9 0.0044 17.3 0.9 1.3 1 0 0 1 1 1 1 Cathelicidin SQAPI PF16845.5 CDW52519.1 - 0.0068 16.7 0.3 0.014 15.8 0.3 1.5 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Ras PF00071.22 CDW52520.1 - 4e-57 192.3 0.1 4.7e-57 192.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52520.1 - 2.4e-31 108.4 0.0 3.6e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52520.1 - 1e-15 57.7 0.0 1.3e-15 57.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW52520.1 - 3.6e-07 29.8 0.0 4.2e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDW52520.1 - 1.6e-06 27.8 0.1 3e-05 23.6 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW52520.1 - 2.4e-05 24.3 0.1 0.092 12.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDW52520.1 - 6.2e-05 23.1 0.0 8.8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 CDW52520.1 - 0.001 18.6 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 CDW52520.1 - 0.0024 18.2 0.1 0.0039 17.6 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 CDW52520.1 - 0.0031 17.0 0.0 0.0046 16.4 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 CDW52520.1 - 0.0037 17.6 0.0 0.009 16.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain Septin PF00735.18 CDW52520.1 - 0.011 15.0 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Septin ATPase PF06745.13 CDW52520.1 - 0.055 12.8 0.1 0.11 11.8 0.0 1.6 1 1 1 2 2 2 0 KaiC ATP_bind_1 PF03029.17 CDW52520.1 - 0.071 12.9 0.0 3.7 7.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 CDW52520.1 - 0.073 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CDW52520.1 - 0.086 12.1 0.0 2.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_29 PF13555.6 CDW52520.1 - 0.092 12.5 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 CDW52520.1 - 0.11 11.6 0.1 0.3 10.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PLAT PF01477.23 CDW52521.1 - 4.5e-22 78.8 0.1 5.9e-22 78.4 0.1 1.1 1 0 0 1 1 1 1 PLAT/LH2 domain Forkhead PF00250.18 CDW52522.1 - 1.4e-39 134.3 0.1 2.2e-39 133.6 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain GtrA PF04138.14 CDW52523.1 - 0.01 16.0 0.2 0.015 15.5 0.2 1.3 1 0 0 1 1 1 0 GtrA-like protein DUF2062 PF09835.9 CDW52523.1 - 0.026 14.4 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) CbtA PF09490.10 CDW52523.1 - 0.2 11.4 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) Sugar_tr PF00083.24 CDW52524.1 - 2.5e-18 66.2 21.8 1.6e-17 63.5 21.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW52524.1 - 1.3e-15 57.2 26.9 1.8e-15 56.7 25.8 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW52525.1 - 2.2e-20 73.0 25.0 4e-20 72.1 21.2 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CDW52525.1 - 3.6e-19 68.9 31.8 8e-19 67.8 31.7 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Ctr PF04145.15 CDW52525.1 - 0.65 10.6 11.5 0.39 11.3 6.0 2.8 2 1 0 2 2 2 0 Ctr copper transporter family MFS_1 PF07690.16 CDW52526.1 - 2.1e-29 102.6 25.7 4.2e-29 101.6 25.2 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW52526.1 - 7.7e-24 84.4 14.3 4.8e-23 81.8 14.3 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 CDW52526.1 - 1.6e-06 27.7 5.6 1.6e-06 27.7 5.6 2.3 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 CDW52526.1 - 0.0028 16.3 17.5 0.0097 14.5 3.6 2.7 2 1 0 2 2 2 2 MFS/sugar transport protein TRI12 PF06609.13 CDW52526.1 - 0.058 11.8 5.7 0.0079 14.7 1.4 1.7 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Pkinase PF00069.25 CDW52527.1 - 1.1e-73 247.9 0.0 1.4e-73 247.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52527.1 - 1e-37 129.8 0.0 1.4e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 CDW52527.1 - 1.5e-16 60.8 0.0 3.3e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.24 CDW52527.1 - 4.3e-08 33.7 4.3 1.1e-07 32.4 4.3 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 CDW52527.1 - 4.6e-08 32.7 0.0 2.8e-07 30.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDW52527.1 - 0.061 12.1 0.0 0.092 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PH_11 PF15413.6 CDW52527.1 - 0.13 12.7 0.2 0.57 10.6 0.2 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain MBOAT PF03062.19 CDW52528.1 - 3.8e-34 118.6 21.8 5.8e-34 118.0 21.8 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DDA1 PF10172.9 CDW52529.1 - 0.22 11.8 4.2 1.5 9.1 0.2 3.0 2 1 0 2 2 2 0 Det1 complexing ubiquitin ligase DNA_primase_lrg PF04104.14 CDW52530.1 - 6.8e-41 140.4 1.1 1.1e-40 139.7 1.1 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit ADAM_CR_2 PF17771.1 CDW52531.1 - 0.0019 18.7 7.6 0.0019 18.7 7.6 3.1 3 3 0 3 3 3 1 ADAM cysteine-rich domain UCR_TM PF02921.14 CDW52531.1 - 0.017 15.6 0.9 0.034 14.6 0.9 1.5 1 0 0 1 1 1 0 Ubiquinol cytochrome reductase transmembrane region DUF4971 PF16341.5 CDW52531.1 - 0.2 11.5 1.5 0.38 10.6 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4971) Homeodomain PF00046.29 CDW52532.1 - 1.9e-09 37.2 2.2 2.8e-09 36.7 2.2 1.3 1 0 0 1 1 1 1 Homeodomain DUF4147 PF13660.6 CDW52533.1 - 3.2e-61 206.8 0.4 1.7e-38 132.5 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4147) MOFRL PF05161.13 CDW52533.1 - 2.6e-30 104.8 0.0 4.3e-30 104.1 0.0 1.4 1 0 0 1 1 1 1 MOFRL family HECT PF00632.25 CDW52534.1 - 2.8e-82 276.7 0.2 9.8e-82 274.9 0.2 1.9 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.18 CDW52534.1 - 3.3e-76 251.7 21.0 2.7e-14 53.5 0.2 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDW52534.1 - 3.5e-38 128.6 38.1 6.2e-11 41.8 4.3 8.6 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat IMS PF00817.20 CDW52535.1 - 1.1e-45 155.3 0.0 2.2e-45 154.3 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CDW52535.1 - 9e-10 39.3 0.0 2e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain LIM PF00412.22 CDW52536.1 - 9.3e-43 144.3 49.6 1e-12 48.1 9.8 4.4 4 0 0 4 4 4 4 LIM domain PDZ PF00595.24 CDW52536.1 - 1e-12 48.2 0.0 1.9e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW52536.1 - 3e-10 39.8 0.2 6.5e-10 38.7 0.2 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW52536.1 - 0.0054 17.0 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DEAD PF00270.29 CDW52537.1 - 1.7e-32 112.6 0.0 2.8e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW52537.1 - 1.1e-17 64.3 0.1 1.5e-16 60.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW52537.1 - 3.5e-09 36.9 0.0 5.9e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDW52537.1 - 0.0027 18.0 0.1 0.015 15.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain SWI2_SNF2 PF18766.1 CDW52537.1 - 0.017 14.8 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase I-set PF07679.16 CDW52538.1 - 0 1476.5 29.3 5.4e-19 68.0 0.0 35.9 36 0 0 36 36 34 33 Immunoglobulin I-set domain fn3 PF00041.21 CDW52538.1 - 0 1411.8 49.0 4.8e-17 62.1 0.1 31.0 30 0 0 30 30 30 30 Fibronectin type III domain Ig_3 PF13927.6 CDW52538.1 - 4.1e-278 898.9 28.3 2e-13 50.7 0.1 33.8 33 0 0 33 33 33 30 Immunoglobulin domain Ig_2 PF13895.6 CDW52538.1 - 3.3e-133 434.3 26.8 1.5e-07 31.7 0.0 30.9 30 2 1 31 31 30 25 Immunoglobulin domain ig PF00047.25 CDW52538.1 - 6.5e-129 420.4 36.2 3.6e-06 27.1 0.0 29.0 29 0 0 29 29 28 24 Immunoglobulin domain Pkinase PF00069.25 CDW52538.1 - 1.8e-72 243.9 0.0 2.6e-72 243.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain V-set PF07686.17 CDW52538.1 - 1.3e-63 211.9 38.9 0.01 16.0 0.0 32.3 30 9 0 30 30 29 15 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 CDW52538.1 - 1.7e-47 159.9 16.0 0.71 10.5 0.3 28.1 28 1 0 28 28 27 7 Purple acid Phosphatase, N-terminal domain Pkinase_Tyr PF07714.17 CDW52538.1 - 4.8e-37 127.6 0.0 7.8e-37 127.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Tissue_fac PF01108.17 CDW52538.1 - 1.1e-28 99.2 0.0 0.48 10.3 0.0 20.8 27 0 0 27 27 24 1 Tissue factor C2-set_2 PF08205.12 CDW52538.1 - 1.9e-25 88.8 31.4 0.014 15.4 0.1 19.6 22 0 0 22 22 19 5 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 CDW52538.1 - 3e-23 82.1 10.0 0.83 9.9 0.0 20.3 25 0 0 25 25 21 2 Natural killer cell receptor 2B4 Y_Y_Y PF07495.13 CDW52538.1 - 7.4e-23 80.3 7.6 0.67 9.9 0.0 19.0 23 0 0 23 23 21 4 Y_Y_Y domain DUF2369 PF10179.9 CDW52538.1 - 2e-12 47.3 0.0 29 5.1 0.0 13.8 17 0 0 17 17 13 0 Uncharacterised conserved protein (DUF2369) DUF4959 PF16323.5 CDW52538.1 - 2.4e-11 43.9 0.7 6.1 7.2 0.0 9.7 10 0 0 10 10 8 0 Domain of unknown function (DUF4959) PhoD_N PF16655.5 CDW52538.1 - 2.9e-10 40.6 0.4 2.8 8.5 0.0 13.4 19 0 0 19 19 13 1 PhoD-like phosphatase, N-terminal domain fn3_2 PF16893.5 CDW52538.1 - 4.2e-10 39.6 0.0 15 5.8 0.0 11.2 13 0 0 13 13 10 0 Fibronectin type III domain Ig_6 PF18452.1 CDW52538.1 - 1.8e-08 33.8 0.4 4.7 6.9 0.1 9.6 10 0 0 10 10 9 1 Immunoglobulin domain Ig_5 PF16681.5 CDW52538.1 - 6.2e-07 29.7 23.4 5 7.6 0.1 14.1 17 1 0 17 17 11 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Pkinase_fungal PF17667.1 CDW52538.1 - 5.3e-06 25.5 0.1 9.4e-06 24.6 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Izumo-Ig PF16706.5 CDW52538.1 - 1.2e-05 25.2 23.0 0.79 9.8 0.6 13.1 16 0 0 16 16 14 1 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 CDW52538.1 - 1.3e-05 25.2 0.2 26 4.9 0.0 8.1 9 0 0 9 9 7 0 C17orf99 Ig domain PA14 PF07691.12 CDW52538.1 - 4e-05 23.5 0.0 13 5.6 0.0 9.0 11 0 0 11 11 11 0 PA14 domain Filamin PF00630.19 CDW52538.1 - 0.0053 17.6 5.5 67 4.4 0.0 9.2 13 0 0 13 13 3 0 Filamin/ABP280 repeat Kdo PF06293.14 CDW52538.1 - 0.006 16.0 0.2 0.011 15.1 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDW52538.1 - 0.0076 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pollen_allerg_1 PF01357.21 CDW52538.1 - 0.033 14.2 1.3 22 5.2 0.0 5.1 4 0 0 4 4 3 0 Pollen allergen CDC48_2 PF02933.17 CDW52538.1 - 0.045 13.5 3.4 18 5.2 0.1 5.2 5 0 0 5 5 3 0 Cell division protein 48 (CDC48), domain 2 bMG6 PF17962.1 CDW52538.1 - 0.33 11.1 24.6 79 3.5 0.0 14.2 18 0 0 18 18 14 0 Bacterial macroglobulin domain 6 Ig_4 PF16680.5 CDW52538.1 - 2.6 8.4 35.4 13 6.1 0.0 12.9 17 0 0 17 17 13 0 T-cell surface glycoprotein CD3 delta chain Yip1 PF04893.17 CDW52539.1 - 6.3e-07 29.3 10.3 9.8e-07 28.6 10.3 1.3 1 1 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 CDW52539.1 - 0.00067 19.2 9.9 0.029 13.9 0.0 2.1 2 0 0 2 2 2 2 YIF1 DUF4692 PF15763.5 CDW52539.1 - 0.0095 16.4 0.1 0.017 15.6 0.1 1.4 1 0 0 1 1 1 1 Regulator of human erythroid cell expansion (RHEX) HMG_box PF00505.19 CDW52541.1 - 1.5e-18 67.0 3.3 3.2e-18 65.9 3.3 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW52541.1 - 1.1e-10 41.9 1.5 3.3e-10 40.4 1.5 1.7 1 0 0 1 1 1 1 HMG-box domain Sporozoite_P67 PF05642.11 CDW52541.1 - 4.3 5.3 9.4 8.5 4.3 9.4 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase PF00069.25 CDW52543.1 - 4.9e-73 245.8 0.0 5.7e-73 245.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52543.1 - 4.1e-36 124.6 0.0 5.3e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW52543.1 - 1.3e-07 31.3 0.0 1.8e-07 30.8 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CDW52543.1 - 0.0003 19.8 0.1 0.00042 19.4 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CDW52543.1 - 0.016 14.9 0.3 0.78 9.3 0.2 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 LAMTOR PF15454.6 CDW52545.1 - 1.8e-11 44.5 1.7 2.7e-11 43.9 1.7 1.3 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator bZIP_2 PF07716.15 CDW52546.1 - 1.3e-12 47.6 16.2 1.3e-12 47.6 16.2 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 CDW52546.1 - 0.001 19.1 9.5 0.001 19.1 9.5 1.7 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 CDW52547.1 - 1e-12 47.9 17.6 1e-12 47.9 17.6 1.6 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 CDW52547.1 - 0.00065 19.8 10.8 0.00065 19.8 10.8 1.6 2 0 0 2 2 2 1 bZIP transcription factor CENP-F_leu_zip PF10473.9 CDW52548.1 - 1.3e-06 28.5 3.6 1.3e-06 28.5 3.6 11.8 7 3 4 11 11 11 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 CDW52548.1 - 0.0014 18.9 22.0 0.0014 18.9 22.0 10.8 8 3 1 9 9 9 4 Autophagy protein 16 (ATG16) TFA2_Winged_2 PF18121.1 CDW52548.1 - 0.014 15.0 0.5 0.17 11.6 0.0 3.2 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 DNA_pol_A_exo1 PF01612.20 CDW52549.1 - 2.5e-15 56.6 0.0 5.6e-15 55.5 0.0 1.6 1 0 0 1 1 1 1 3'-5' exonuclease DUF2677 PF10838.8 CDW52549.1 - 0.058 13.4 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2677) VacA PF02691.15 CDW52549.1 - 0.089 10.7 0.0 0.12 10.2 0.0 1.1 1 0 0 1 1 1 0 Vacuolating cyotoxin MCRS_N PF13325.6 CDW52550.1 - 5.7e-42 144.0 0.1 8.2e-42 143.5 0.1 1.2 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein Terminase_GpA PF05876.12 CDW52550.1 - 0.022 13.3 0.1 0.033 12.8 0.1 1.2 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) DUF1870 PF08965.10 CDW52551.1 - 0.012 15.6 0.1 0.042 13.9 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) Urb2 PF10441.9 CDW52551.1 - 0.54 10.2 12.6 0.054 13.4 6.0 2.8 2 2 0 2 2 2 0 Urb2/Npa2 family Dickkopf_N PF04706.12 CDW52552.1 - 1.7e-18 66.8 141.1 0.011 16.2 14.0 10.3 8 3 1 9 9 9 9 Dickkopf N-terminal cysteine-rich region EB PF01683.18 CDW52552.1 - 6.7e-16 58.3 139.9 0.00057 20.1 10.2 11.9 2 2 12 14 14 14 13 EB module CarbpepA_inh PF02977.15 CDW52552.1 - 0.067 13.0 0.8 0.067 13.0 0.8 11.6 3 3 5 9 9 9 0 Carboxypeptidase A inhibitor EB PF01683.18 CDW52553.1 - 1.9e-07 31.3 208.5 0.036 14.4 9.0 18.1 5 3 16 21 21 21 18 EB module Dickkopf_N PF04706.12 CDW52553.1 - 0.00013 22.4 229.2 0.033 14.7 14.1 15.0 9 4 6 15 15 15 9 Dickkopf N-terminal cysteine-rich region DUF3715 PF12509.8 CDW52553.1 - 0.43 10.5 4.4 0.43 10.6 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3715) PDZ PF00595.24 CDW52555.1 - 3.5e-20 72.1 0.7 5.4e-20 71.5 0.7 1.3 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 CDW52555.1 - 5.9e-17 61.2 0.0 1.3e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 L27 domain PDZ_6 PF17820.1 CDW52555.1 - 3.8e-12 45.9 0.7 7.6e-12 44.9 0.2 1.7 2 0 0 2 2 2 1 PDZ domain Lung_7-TM_R PF06814.13 CDW52557.1 - 1.8e-50 171.8 15.5 2.6e-50 171.3 15.5 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 CDW52557.1 - 4.5e-05 23.0 22.7 0.00027 20.4 22.7 2.1 1 1 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain DUF5337 PF17272.2 CDW52557.1 - 0.0071 16.1 0.1 0.16 11.8 0.0 2.5 1 1 1 2 2 2 1 Family of unknown function (DUF5337) NPDC1 PF06809.11 CDW52558.1 - 4.8e-22 78.5 0.0 7e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) Laminin_G_3 PF13385.6 CDW52559.1 - 1.6e-16 60.8 0.0 5.8e-16 59.0 0.0 1.9 1 1 1 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Sushi PF00084.20 CDW52559.1 - 9.2e-08 32.6 45.0 0.0061 17.1 0.6 8.6 7 1 0 7 7 7 3 Sushi repeat (SCR repeat) Peptidase_M43 PF05572.13 CDW52559.1 - 3.4e-05 23.8 3.0 0.00016 21.6 3.0 2.1 1 1 0 1 1 1 1 Pregnancy-associated plasma protein-A Notch PF00066.17 CDW52559.1 - 0.0023 18.3 5.5 0.0023 18.3 5.5 6.5 7 0 0 7 7 7 3 LNR domain UL42 PF17638.2 CDW52559.1 - 0.04 13.9 1.5 0.11 12.5 1.5 1.7 1 0 0 1 1 1 0 HCMV UL42 Laminin_G_2 PF02210.24 CDW52559.1 - 0.093 13.3 0.0 0.3 11.7 0.0 1.8 2 0 0 2 2 2 0 Laminin G domain Peptidase_M66 PF10462.9 CDW52559.1 - 0.16 10.9 1.7 0.28 10.1 1.7 1.3 1 0 0 1 1 1 0 Peptidase M66 Astacin PF01400.24 CDW52559.1 - 0.18 11.4 1.7 0.44 10.1 1.7 1.6 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 CDW52559.1 - 0.2 11.5 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Matrixin Pou PF00157.17 CDW52560.1 - 1.2e-29 102.1 0.5 2.2e-29 101.3 0.1 1.7 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 CDW52560.1 - 1.4e-16 60.1 3.2 4.5e-16 58.4 3.2 2.0 1 0 0 1 1 1 1 Homeodomain DUF2407_C PF13373.6 CDW52560.1 - 0.0055 16.9 1.4 0.013 15.6 1.4 1.6 1 0 0 1 1 1 1 DUF2407 C-terminal domain Homeobox_KN PF05920.11 CDW52560.1 - 0.012 15.5 0.1 0.042 13.8 0.1 1.9 1 0 0 1 1 1 0 Homeobox KN domain HTH_3 PF01381.22 CDW52560.1 - 0.012 15.6 0.2 0.035 14.2 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix Androgen_recep PF02166.16 CDW52560.1 - 0.017 14.0 0.4 0.024 13.5 0.4 1.2 1 0 0 1 1 1 0 Androgen receptor HTH_31 PF13560.6 CDW52560.1 - 0.023 15.1 0.0 0.023 15.1 0.0 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain Lsr2 PF11774.8 CDW52560.1 - 4.4 7.5 10.2 1.3 9.2 5.5 2.4 2 1 0 2 2 2 0 Lsr2 DUF2358 PF10184.9 CDW52562.1 - 2.7e-14 53.4 0.3 3.9e-14 52.9 0.3 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) STIMATE PF12400.8 CDW52563.1 - 5.6e-30 104.5 10.0 8.9e-30 103.8 10.0 1.3 1 0 0 1 1 1 1 STIMATE family Vpu PF00558.19 CDW52563.1 - 0.14 12.0 0.3 2 8.2 0.0 2.5 2 0 0 2 2 2 0 Vpu protein Clathrin PF00637.20 CDW52564.1 - 0.00073 19.4 0.2 0.089 12.7 0.0 2.8 1 1 1 3 3 3 2 Region in Clathrin and VPS ANAPC3 PF12895.7 CDW52564.1 - 0.2 11.9 1.2 11 6.3 0.2 3.0 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 EHN PF06441.12 CDW52565.1 - 5.4e-33 113.6 0.1 1.6e-32 112.1 0.1 1.9 2 0 0 2 2 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CDW52565.1 - 3.8e-13 49.7 0.0 1e-12 48.3 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold GST_N_3 PF13417.6 CDW52565.1 - 2.4e-07 31.1 0.0 1.2e-06 28.8 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CDW52565.1 - 7.2e-06 26.1 0.1 2.4e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Glutaredoxin GST_N_4 PF17172.4 CDW52565.1 - 0.0001 23.0 0.0 0.00037 21.2 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 CDW52565.1 - 0.00015 21.7 0.0 0.00034 20.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CDW52565.1 - 0.00035 20.8 0.0 0.00088 19.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDW52565.1 - 0.00041 20.5 0.0 0.001 19.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Abhydrolase_6 PF12697.7 CDW52565.1 - 0.0014 19.2 0.0 0.0073 16.9 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family GST_N PF02798.20 CDW52565.1 - 0.013 15.8 0.1 0.045 14.1 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDW52565.1 - 0.093 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glyco_transf_24 PF18404.1 CDW52566.1 - 4.3e-107 357.5 9.5 5.5e-99 330.9 5.1 3.4 1 1 1 2 2 2 2 Glucosyltransferase 24 Thioredoxin_15 PF18403.1 CDW52566.1 - 4.1e-41 141.3 3.8 2e-39 135.7 0.3 3.2 4 0 0 4 4 4 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 CDW52566.1 - 1.5e-40 139.2 0.0 3.4e-40 138.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_14 PF18402.1 CDW52566.1 - 5e-33 115.1 0.3 1.9e-31 110.0 0.0 3.3 3 1 0 3 3 3 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 CDW52566.1 - 1.2e-32 112.2 0.0 3.2e-32 110.9 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 CDW52566.1 - 6.3e-25 87.7 1.5 2.6e-24 85.7 0.1 2.5 3 0 0 3 3 3 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 CDW52566.1 - 0.00058 19.5 0.2 0.0012 18.5 0.2 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 GCFC PF07842.12 CDW52567.1 - 3.2e-17 63.1 0.2 7.8e-10 38.8 0.1 2.3 1 1 1 2 2 2 2 GC-rich sequence DNA-binding factor-like protein Serglycin PF04360.12 CDW52567.1 - 0.031 14.2 0.3 0.32 10.9 0.0 2.3 2 0 0 2 2 2 0 Serglycin DUF1697 PF08002.11 CDW52567.1 - 0.095 13.2 0.2 0.24 11.9 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1697) RhoGEF PF00621.20 CDW52568.1 - 5.6e-37 127.7 0.0 1e-36 126.9 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.28 CDW52568.1 - 1.9e-19 69.0 0.0 4.9e-12 45.3 0.0 2.6 2 0 0 2 2 2 2 SH3 domain CH PF00307.31 CDW52568.1 - 3.8e-17 62.4 1.0 9.7e-17 61.1 0.4 1.9 2 0 0 2 2 2 1 Calponin homology (CH) domain SH2 PF00017.24 CDW52568.1 - 4e-15 55.7 0.2 1e-14 54.3 0.2 1.8 1 0 0 1 1 1 1 SH2 domain SH3_9 PF14604.6 CDW52568.1 - 4.3e-15 55.3 0.0 1.6e-08 34.2 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 CDW52568.1 - 8.5e-15 54.2 0.0 2.8e-08 33.3 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain CAMSAP_CH PF11971.8 CDW52568.1 - 3e-13 49.4 1.6 3.9e-13 49.1 0.4 1.8 2 0 0 2 2 1 1 CAMSAP CH domain C1_1 PF00130.22 CDW52568.1 - 8.1e-08 32.0 7.8 1.9e-07 30.8 7.8 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CDW52568.1 - 0.015 15.6 6.3 0.04 14.2 6.3 1.8 1 0 0 1 1 1 0 C1 domain Zf_RING PF16744.5 CDW52568.1 - 0.079 13.1 1.7 0.28 11.3 1.7 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger PH PF00169.29 CDW52568.1 - 0.092 13.3 0.0 0.31 11.6 0.0 1.9 1 0 0 1 1 1 0 PH domain zf-RING-like PF08746.11 CDW52568.1 - 0.94 9.8 5.3 2.8 8.3 5.3 1.9 1 0 0 1 1 1 0 RING-like domain LIM PF00412.22 CDW52569.1 - 2.2e-31 107.8 23.3 2e-16 59.9 4.1 2.3 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 CDW52569.1 - 5.2e-21 74.2 1.6 1.1e-20 73.2 1.6 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW52569.1 - 0.00066 19.5 0.0 0.0018 18.1 0.0 1.8 1 1 0 1 1 1 1 Homeobox KN domain EHN PF06441.12 CDW52570.1 - 5.9e-31 107.0 0.1 1.2e-30 106.1 0.1 1.6 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CDW52570.1 - 5.7e-11 42.6 0.0 1.5e-10 41.2 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW52570.1 - 2.7e-05 24.9 0.1 8.3e-05 23.3 0.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family GLTP PF08718.11 CDW52571.1 - 2.8e-29 102.3 0.3 3.5e-29 102.0 0.3 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) UTP25 PF06862.12 CDW52571.1 - 0.021 13.6 0.1 0.029 13.1 0.1 1.1 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Ribonuc_red_sm PF00268.21 CDW52572.1 - 1.1e-118 395.7 1.8 1.3e-118 395.5 1.8 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain fn3 PF00041.21 CDW52573.1 - 5.5e-72 238.1 0.0 3.6e-12 46.5 0.0 10.5 10 0 0 10 10 10 9 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 CDW52573.1 - 3.4e-20 72.4 0.0 0.016 15.7 0.0 9.5 9 1 0 9 9 9 4 Purple acid Phosphatase, N-terminal domain Y_Y_Y PF07495.13 CDW52573.1 - 0.0011 18.9 0.0 3.4 7.7 0.0 5.2 6 0 0 6 6 6 1 Y_Y_Y domain DUF2369 PF10179.9 CDW52573.1 - 0.0013 19.1 1.9 6.4 7.2 0.1 5.9 9 0 0 9 9 9 1 Uncharacterised conserved protein (DUF2369) fn3_4 PF16794.5 CDW52573.1 - 0.033 14.1 0.0 31 4.6 0.0 4.6 5 1 0 5 5 5 0 Fibronectin-III type domain CD45 PF12567.8 CDW52573.1 - 0.034 14.1 0.2 1.4 8.9 0.1 2.6 2 0 0 2 2 2 0 Leukocyte receptor CD45 CAP_N PF01213.19 CDW52573.1 - 4.5 6.7 24.7 0.13 11.8 11.7 2.9 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal eIF2A PF08662.11 CDW52574.1 - 1.2e-18 67.8 0.0 1.8e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A FAM76 PF16046.5 CDW52574.1 - 0.11 11.8 4.0 0.14 11.5 4.0 1.1 1 0 0 1 1 1 0 FAM76 protein eIF2A PF08662.11 CDW52575.1 - 2.5e-25 89.5 0.0 2.8e-25 89.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A GATase PF00117.28 CDW52575.1 - 0.029 14.1 0.0 0.033 14.0 0.0 1.1 1 0 0 1 1 1 0 Glutamine amidotransferase class-I Calponin PF00402.18 CDW52577.1 - 3.1e-45 151.4 23.7 2.1e-13 49.6 0.8 6.7 6 0 0 6 6 6 6 Calponin family repeat Elongin_A PF06881.11 CDW52578.1 - 4.2e-19 69.0 0.0 9.5e-19 67.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Top6b_C PF18000.1 CDW52580.1 - 0.076 13.2 0.1 0.32 11.2 0.0 2.0 2 0 0 2 2 2 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain Prenyltrans PF00432.21 CDW52582.1 - 7.8e-69 227.1 10.3 2.6e-15 55.8 0.4 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 CDW52582.1 - 2.9e-05 23.3 0.0 0.00027 20.1 0.0 2.3 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 CDW52582.1 - 0.052 12.6 0.0 1.2 8.1 0.0 2.9 2 1 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain Pkinase PF00069.25 CDW52583.1 - 6.5e-68 229.0 0.0 7.7e-68 228.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52583.1 - 2.1e-33 115.7 0.0 2.7e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW52583.1 - 1.4e-06 27.8 0.1 4.3e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW52583.1 - 1.8e-05 23.9 0.1 2.5e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 CDW52583.1 - 0.21 10.3 0.1 0.42 9.3 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase Cullin_binding PF03556.15 CDW52584.1 - 1.4e-29 103.0 4.2 1.5e-27 96.5 4.2 2.4 1 1 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 CDW52584.1 - 4.5e-09 36.0 0.0 1.1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain IRF-2BP1_2 PF11261.8 CDW52584.1 - 0.041 13.4 0.0 0.086 12.4 0.0 1.5 1 0 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger F-box_4 PF15966.5 CDW52585.1 - 7e-26 90.4 0.1 7e-26 90.4 0.1 2.5 3 0 0 3 3 3 1 F-box zf-TRAF_2 PF15965.5 CDW52585.1 - 5.4e-24 84.5 28.0 2.4e-23 82.4 20.3 3.3 3 1 0 3 3 3 2 TRAF-like zinc-finger F-box PF00646.33 CDW52585.1 - 2.9e-06 27.0 0.0 6.6e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CDW52585.1 - 5.6e-05 23.0 0.1 5.6e-05 23.0 0.1 2.0 2 0 0 2 2 2 1 F-box-like zf-TRAF PF02176.18 CDW52585.1 - 0.0023 18.6 11.5 0.0023 18.6 11.5 4.4 3 2 1 4 4 4 1 TRAF-type zinc finger TRAPPC9-Trs120 PF08626.11 CDW52586.1 - 7.1e-31 106.5 10.7 1.5e-16 59.0 0.0 5.0 4 1 1 5 5 5 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Trypsin PF00089.26 CDW52586.1 - 1.1e-16 61.3 0.0 8.1e-12 45.4 0.0 2.4 2 0 0 2 2 2 2 Trypsin DUF1986 PF09342.11 CDW52586.1 - 0.063 13.7 0.0 2 8.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1986) TRAPPC-Trs85 PF12739.7 CDW52586.1 - 0.5 9.3 7.4 0.11 11.4 1.8 2.1 2 0 0 2 2 2 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SR-25 PF10500.9 CDW52586.1 - 0.76 9.3 26.4 1.3 8.5 26.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 CDW52586.1 - 1.8 7.3 5.2 2.7 6.7 5.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Chorion_2 PF03964.15 CDW52586.1 - 2.6 9.0 12.5 5.5 7.9 12.5 1.4 1 0 0 1 1 1 0 Chorion family 2 SSP160 PF06933.11 CDW52586.1 - 6.8 4.7 10.4 11 4.1 10.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 AF-4 PF05110.13 CDW52586.1 - 9.5 4.2 26.6 14 3.6 26.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SPX PF03105.19 CDW52586.1 - 9.7 6.0 12.2 15 5.3 12.2 1.2 1 0 0 1 1 1 0 SPX domain Trypsin PF00089.26 CDW52587.1 - 0.011 15.5 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Trypsin SH2 PF00017.24 CDW52588.1 - 1.4e-13 50.7 0.0 4e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 SH2 domain RasGEF PF00617.19 CDW52588.1 - 5.5e-11 43.0 0.0 9e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain Ribosomal_L29 PF00831.23 CDW52589.1 - 2.4e-17 62.6 1.2 2.4e-17 62.6 1.2 1.8 2 0 0 2 2 2 1 Ribosomal L29 protein GCFC PF07842.12 CDW52590.1 - 8.9e-79 265.0 16.5 8.9e-79 265.0 16.5 1.7 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.8 CDW52590.1 - 5.7e-15 55.6 9.2 5.7e-15 55.6 9.2 1.9 2 0 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch PF01585.23 CDW52590.1 - 4.8e-13 48.8 3.6 8.8e-13 47.9 3.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CDW52590.1 - 0.0013 18.8 1.3 0.0013 18.8 1.3 2.2 2 0 0 2 2 2 1 G-patch domain CarbpepA_inh PF02977.15 CDW52591.1 - 0.069 12.9 4.1 0.19 11.6 4.1 1.7 1 0 0 1 1 1 0 Carboxypeptidase A inhibitor UDPGT PF00201.18 CDW52592.1 - 1.3e-57 195.7 2.8 1.7e-57 195.4 2.8 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW52592.1 - 6.3e-10 39.3 0.0 1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Pkinase PF00069.25 CDW52593.1 - 3.1e-73 246.4 0.0 3.7e-73 246.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52593.1 - 1.1e-32 113.3 0.0 1.4e-32 113.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW52593.1 - 5.1e-05 22.4 0.0 0.00017 20.7 0.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW52593.1 - 0.00014 21.3 0.1 0.00078 18.8 0.0 2.0 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 CDW52593.1 - 0.0017 18.4 0.0 0.016 15.1 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW52593.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_47 PF01532.20 CDW52594.1 - 2.2e-106 356.5 0.0 3.2e-106 356.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 UBX PF00789.20 CDW52595.1 - 2.9e-09 37.0 0.0 4.6e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 UBX domain Rib PF08428.10 CDW52595.1 - 0.071 13.1 0.3 0.16 12.0 0.3 1.7 1 1 1 2 2 2 0 Rib/alpha-like repeat NDUFA12 PF05071.16 CDW52597.1 - 1.3e-30 106.0 5.4 1.7e-30 105.7 5.4 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 EGF PF00008.27 CDW52598.1 - 4.9e-75 247.3 255.2 5.6e-08 32.9 6.7 20.6 19 0 0 19 19 19 18 EGF-like domain Ephrin_rec_like PF07699.13 CDW52598.1 - 3.1e-68 225.3 105.1 3.2e-12 46.0 3.5 10.3 8 1 1 9 9 8 7 Putative ephrin-receptor like hEGF PF12661.7 CDW52598.1 - 2.3e-37 126.4 203.8 2.1e-05 25.0 5.2 21.4 20 0 0 20 20 19 15 Human growth factor-like EGF CUB PF00431.20 CDW52598.1 - 1.1e-34 119.1 0.0 7e-16 58.5 0.0 3.6 3 0 0 3 3 3 2 CUB domain HYR PF02494.16 CDW52598.1 - 4.7e-31 106.9 11.9 1.2e-12 48.0 0.2 4.0 3 0 0 3 3 3 3 HYR domain Sushi PF00084.20 CDW52598.1 - 1.4e-23 83.2 92.3 1.4e-07 32.0 0.5 14.0 14 0 0 14 14 12 9 Sushi repeat (SCR repeat) Lectin_C PF00059.21 CDW52598.1 - 6.3e-15 55.8 0.1 6.3e-15 55.8 0.1 2.4 2 0 0 2 2 1 1 Lectin C-type domain EGF_CA PF07645.15 CDW52598.1 - 9.9e-11 41.7 35.6 1.3e-07 31.6 8.1 22.7 12 3 12 24 24 17 9 Calcium-binding EGF domain FXa_inhibition PF14670.6 CDW52598.1 - 2.4e-09 37.3 7.2 2.4e-09 37.3 7.2 23.8 14 7 10 24 24 19 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW52598.1 - 7.1e-09 35.7 10.9 7.1e-09 35.7 10.9 20.7 18 1 2 20 20 19 6 EGF domain Ldl_recept_a PF00057.18 CDW52598.1 - 4.3e-08 33.2 7.2 4.3e-08 33.2 7.2 9.5 9 1 0 9 9 3 1 Low-density lipoprotein receptor domain class A Laminin_G_3 PF13385.6 CDW52598.1 - 9.2e-07 29.1 0.3 2e-06 28.0 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 CDW52598.1 - 0.0012 19.2 12.7 0.0012 19.2 12.7 21.4 20 1 1 21 21 19 10 EGF-like domain Laminin_G_2 PF02210.24 CDW52598.1 - 0.041 14.5 0.2 0.55 10.8 0.0 2.6 3 0 0 3 3 3 0 Laminin G domain Y_phosphatase PF00102.27 CDW52599.1 - 1.7e-33 116.2 0.1 2.3e-33 115.7 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 CDW52599.1 - 0.015 15.1 0.0 0.046 13.5 0.0 1.8 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain MRP-S24 PF14955.6 CDW52600.1 - 9.9e-51 171.3 0.1 1.2e-50 171.0 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S24 Y_phosphatase PF00102.27 CDW52601.1 - 3.6e-61 206.7 4.3 6.5e-60 202.6 4.3 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 CDW52601.1 - 0.0005 19.9 0.1 0.00095 19.0 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CDW52601.1 - 0.097 12.6 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family CyRPA PF18638.1 CDW52601.1 - 0.12 11.5 0.0 0.27 10.4 0.0 1.5 2 0 0 2 2 2 0 Cysteine-Rich Protective Antigen 6 bladed domain Pkinase PF00069.25 CDW52602.1 - 1.3e-127 424.6 0.0 8.4e-71 238.4 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52602.1 - 2.2e-55 187.8 0.0 1.1e-29 103.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDW52602.1 - 5.5e-06 25.9 0.0 0.03 13.6 0.0 2.6 2 1 0 2 2 2 2 Kinase-like APH PF01636.23 CDW52602.1 - 8.5e-06 25.9 0.0 0.05 13.5 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDW52602.1 - 1.5e-05 24.2 0.1 0.0049 15.9 0.0 2.6 3 0 0 3 3 3 2 Haspin like kinase domain Kdo PF06293.14 CDW52602.1 - 0.0017 17.8 0.0 0.59 9.5 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 CDW52602.1 - 0.0091 15.1 0.0 2.5 7.1 0.0 2.4 2 0 0 2 2 2 2 Seadornavirus VP7 DUF5439 PF17507.2 CDW52602.1 - 0.16 12.2 0.3 77 3.6 0.0 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5439) Leader_Trp PF08255.11 CDW52603.1 - 0.0019 18.0 1.2 0.0048 16.7 1.2 1.7 1 0 0 1 1 1 1 Trp-operon Leader Peptide CUT PF02376.15 CDW52604.1 - 1.7e-31 108.2 0.3 3.8e-31 107.1 0.3 1.6 1 0 0 1 1 1 1 CUT domain Homeodomain PF00046.29 CDW52604.1 - 3.4e-11 42.8 0.3 8.3e-11 41.6 0.3 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW52604.1 - 8.8e-05 22.3 0.0 0.00025 20.9 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Spt20 PF12090.8 CDW52604.1 - 0.0065 16.1 26.2 0.011 15.4 23.8 2.2 2 0 0 2 2 2 1 Spt20 family Presenilin PF01080.17 CDW52604.1 - 0.23 10.2 7.0 0.32 9.7 7.0 1.3 1 0 0 1 1 1 0 Presenilin eIF-3_zeta PF05091.12 CDW52604.1 - 0.24 10.3 10.4 0.44 9.5 10.4 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF702 PF05142.12 CDW52604.1 - 0.34 11.4 11.1 0.21 12.0 5.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF702) EOS1 PF12326.8 CDW52604.1 - 0.42 10.5 1.4 0.91 9.4 1.4 1.6 1 0 0 1 1 1 0 N-glycosylation protein DivIC PF04977.15 CDW52604.1 - 0.46 10.3 11.5 0.99 9.2 11.5 1.5 1 0 0 1 1 1 0 Septum formation initiator RLL PF10036.9 CDW52604.1 - 0.58 10.0 11.7 0.13 12.1 6.5 2.2 2 1 1 3 3 3 0 RNA transcription, translation and transport factor protein DUF4569 PF15133.6 CDW52604.1 - 0.59 9.8 11.7 1.3 8.7 11.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Pex14_N PF04695.13 CDW52604.1 - 0.65 10.6 15.2 0.38 11.4 11.1 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region HHH_9 PF17674.1 CDW52604.1 - 1.1 10.3 3.9 11 7.0 1.2 3.2 2 1 1 3 3 3 0 HHH domain WBP-1 PF11669.8 CDW52604.1 - 1.4 9.6 5.3 4.9 7.8 5.3 1.9 1 0 0 1 1 1 0 WW domain-binding protein 1 DUF719 PF05334.13 CDW52604.1 - 1.7 8.8 10.7 4 7.6 4.6 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF719) EIIBC-GUT_N PF03612.14 CDW52604.1 - 2 8.1 10.0 3.3 7.4 6.1 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus TERB2 PF15101.6 CDW52604.1 - 2.1 8.4 13.2 3.3 7.7 12.2 1.7 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Connexin PF00029.19 CDW52604.1 - 2.9 7.6 8.4 5.3 6.7 8.4 1.3 1 0 0 1 1 1 0 Connexin SOXp PF12336.8 CDW52604.1 - 3.2 8.9 12.7 16 6.6 12.0 2.6 2 0 0 2 2 1 0 SOX transcription factor PepSY_TM PF03929.16 CDW52604.1 - 3.5 7.2 7.1 7.2 6.2 7.1 1.5 1 0 0 1 1 1 0 PepSY-associated TM region CLN3 PF02487.17 CDW52604.1 - 3.6 6.6 4.9 3.9 6.4 3.8 1.6 2 0 0 2 2 2 0 CLN3 protein FTZ PF03867.14 CDW52604.1 - 4.2 6.8 17.9 11 5.4 17.9 1.7 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region MPM1 PF17234.2 CDW52604.1 - 4.2 7.6 13.9 0.25 11.6 8.3 1.7 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF4407 PF14362.6 CDW52604.1 - 4.4 6.6 8.5 8.2 5.7 8.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4834 PF16118.5 CDW52604.1 - 6.3 7.8 16.9 1.2 10.1 12.6 2.1 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) Ldl_recept_a PF00057.18 CDW52605.1 - 2.9e-53 177.8 121.6 3.1e-11 43.3 6.7 8.3 8 1 0 8 8 8 6 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 CDW52605.1 - 3.5e-21 75.4 1.9 1.5e-07 31.8 0.1 4.7 4 0 0 4 4 4 3 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 CDW52605.1 - 7e-13 48.6 27.8 2.2e-08 34.3 12.5 7.0 8 0 0 8 8 8 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW52605.1 - 3.5e-05 23.6 10.8 0.00041 20.2 2.4 5.5 5 0 0 5 5 5 2 Complement Clr-like EGF-like EGF_CA PF07645.15 CDW52605.1 - 0.00073 19.7 9.9 0.00073 19.7 9.9 10.3 5 1 3 9 9 9 2 Calcium-binding EGF domain EGF PF00008.27 CDW52605.1 - 0.0051 17.1 8.8 0.0051 17.1 8.8 9.3 11 2 0 11 11 11 3 EGF-like domain DUF5050 PF16472.5 CDW52605.1 - 0.092 12.0 0.0 0.72 9.0 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5050) GATA PF00320.27 CDW52606.1 - 7.3e-30 102.3 19.8 5.8e-15 54.6 5.2 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 CDW52606.1 - 6.7e-06 25.5 8.7 0.012 15.1 0.7 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 CDW52606.1 - 0.00084 19.4 1.6 0.32 11.1 0.1 2.7 2 1 0 2 2 2 2 Zinc ribbon domain Elf1 PF05129.13 CDW52606.1 - 0.0013 18.8 2.0 0.12 12.4 0.2 2.5 1 1 1 2 2 2 1 Transcription elongation factor Elf1 like Prim_Zn_Ribbon PF08273.12 CDW52606.1 - 0.0044 17.3 10.9 0.28 11.5 2.8 2.7 2 0 0 2 2 2 2 Zinc-binding domain of primase-helicase ArfGap PF01412.18 CDW52606.1 - 0.0071 16.4 6.6 0.11 12.6 0.4 2.5 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf Auto_anti-p27 PF06677.12 CDW52606.1 - 0.02 15.0 5.7 0.71 10.1 0.4 2.5 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF2387 PF09526.10 CDW52606.1 - 0.025 14.7 3.4 18 5.6 0.3 3.4 1 1 2 3 3 3 0 Probable metal-binding protein (DUF2387) DZR PF12773.7 CDW52606.1 - 0.053 13.6 8.8 3 7.9 2.0 2.9 1 1 2 3 3 3 0 Double zinc ribbon eIF-5_eIF-2B PF01873.17 CDW52606.1 - 0.069 13.0 4.4 2 8.3 0.6 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 TDP43_N PF18694.1 CDW52606.1 - 0.072 12.9 0.3 2.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Transactive response DNA-binding protein N-terminal domain zf-ribbon_3 PF13248.6 CDW52606.1 - 0.29 10.6 14.6 3.2 7.3 0.4 4.2 4 0 0 4 4 4 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 CDW52606.1 - 1.3 8.8 12.8 16 5.3 0.1 4.3 4 0 0 4 4 4 0 Rubredoxin metal binding domain zinc_ribbon_15 PF17032.5 CDW52606.1 - 4.2 8.2 8.8 4.6 8.1 2.1 3.1 1 1 2 3 3 3 0 zinc-ribbon family Tyrosinase PF00264.20 CDW52607.1 - 1.1e-19 71.6 0.1 1.2e-11 45.4 0.1 2.4 1 1 1 2 2 2 2 Common central domain of tyrosinase DUF4892 PF16234.5 CDW52607.1 - 0.14 11.6 0.1 0.46 9.9 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4892) PDZ PF00595.24 CDW52608.1 - 4.1e-42 142.4 1.2 6e-13 49.0 0.0 3.3 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 CDW52608.1 - 5.2e-27 93.5 0.5 1.2e-07 31.4 0.0 3.5 3 0 0 3 3 3 3 PDZ domain FERM_M PF00373.18 CDW52608.1 - 3.3e-23 82.3 1.9 3.3e-23 82.3 1.9 2.0 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 CDW52608.1 - 1e-13 51.5 0.2 2.3e-13 50.3 0.2 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain PDZ_2 PF13180.6 CDW52608.1 - 3.6e-13 49.6 0.3 2.1e-06 28.0 0.1 3.4 3 0 0 3 3 3 3 PDZ domain FERM_N PF09379.10 CDW52608.1 - 4.8e-12 45.6 0.0 9.6e-12 44.7 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain UCH PF00443.29 CDW52611.1 - 1.5e-54 185.2 0.0 1.8e-54 185.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW52611.1 - 4.4e-17 62.7 0.4 1e-10 41.8 0.3 3.1 2 1 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase PHD_Oberon PF07227.11 CDW52611.1 - 6.4 6.7 10.6 21 5.0 0.0 3.5 3 0 0 3 3 3 0 PHD - plant homeodomain finger protein Tim44 PF04280.15 CDW52612.1 - 0.00089 19.4 0.7 0.0013 18.8 0.7 1.4 1 1 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 CDW52612.1 - 0.023 13.7 0.0 0.031 13.4 0.0 1.3 1 1 0 1 1 1 0 MBA1-like protein FMO-like PF00743.19 CDW52613.1 - 2.2e-171 570.9 0.0 2.8e-171 570.6 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CDW52613.1 - 1.5e-22 80.2 0.0 1.5e-19 70.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CDW52613.1 - 3.6e-15 55.9 0.2 1.1e-12 47.7 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CDW52613.1 - 7.9e-14 51.6 0.0 4e-12 46.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDW52613.1 - 8.1e-07 29.5 0.5 0.028 15.0 0.0 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW52613.1 - 5.9e-06 26.4 0.0 3e-05 24.2 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDW52613.1 - 2e-05 24.4 0.1 0.0041 16.8 0.0 3.0 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CDW52613.1 - 2.7e-05 24.2 1.6 0.085 12.8 0.9 4.0 3 1 0 3 3 3 1 FAD-NAD(P)-binding Thi4 PF01946.17 CDW52613.1 - 0.024 13.9 0.0 0.25 10.5 0.0 2.3 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 CDW52613.1 - 0.035 13.4 0.0 0.068 12.4 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain Mqo PF06039.15 CDW52613.1 - 0.091 11.3 0.1 0.22 10.1 0.0 1.5 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) NAD_binding_7 PF13241.6 CDW52613.1 - 0.11 12.9 0.0 2.8 8.4 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 CDW52613.1 - 0.23 10.1 0.0 0.52 8.9 0.0 1.6 1 0 0 1 1 1 0 HI0933-like protein Hint PF01079.20 CDW52615.1 - 2e-36 125.5 0.2 2.9e-36 125.0 0.2 1.1 1 0 0 1 1 1 1 Hint module Crust_neurohorm PF01147.17 CDW52616.1 - 1.7e-11 43.8 2.3 2.1e-11 43.5 2.3 1.1 1 0 0 1 1 1 1 Crustacean CHH/MIH/GIH neurohormone family ApbA_C PF08546.11 CDW52616.1 - 0.16 12.2 0.0 0.16 12.2 0.0 1.1 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Abhydrolase_1 PF00561.20 CDW52617.1 - 5.2e-21 75.4 2.6 3.6e-15 56.3 0.3 3.4 3 1 0 3 3 3 2 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 CDW52617.1 - 9.2e-21 73.2 0.1 7.4e-20 70.3 0.0 2.3 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 CDW52617.1 - 5e-05 22.7 0.1 0.0062 15.8 0.0 3.8 3 2 1 4 4 4 1 Serine aminopeptidase, S33 FSH1 PF03959.13 CDW52617.1 - 0.014 15.1 0.2 5.8 6.5 0.0 3.1 3 0 0 3 3 3 0 Serine hydrolase (FSH1) E1-E2_ATPase PF00122.20 CDW52618.1 - 2.2e-17 63.2 0.2 1.3e-16 60.7 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CDW52618.1 - 4.4e-13 50.0 0.0 1.1e-06 29.2 0.0 2.7 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDW52618.1 - 0.027 14.5 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) SHP PF03579.13 CDW52618.1 - 0.5 10.4 3.3 30 4.7 2.3 2.8 2 0 0 2 2 2 0 Small hydrophobic protein Moulting_cycle PF04870.16 CDW52619.1 - 1e-07 31.6 16.5 1.6e-07 30.9 0.2 4.9 5 0 0 5 5 5 2 Moulting cycle Exonuc_VII_L PF02601.15 CDW52619.1 - 0.033 13.8 0.3 0.053 13.1 0.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit WD40 PF00400.32 CDW52620.1 - 3.2e-10 40.4 8.1 0.0011 19.8 0.1 6.7 5 1 1 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52620.1 - 1.9e-09 37.7 0.3 0.19 12.0 0.0 5.4 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 CDW52620.1 - 0.00022 20.4 4.3 0.0035 16.4 1.6 3.3 2 1 0 3 3 3 1 Coatomer WD associated region Clathrin PF00637.20 CDW52620.1 - 0.001 19.0 4.8 0.2 11.5 0.8 3.8 3 1 1 4 4 4 2 Region in Clathrin and VPS eIF2A PF08662.11 CDW52620.1 - 0.03 14.2 0.1 0.15 11.9 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDW52620.1 - 0.046 12.7 0.1 0.25 10.3 0.0 2.1 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TPR_2 PF07719.17 CDW52620.1 - 0.1 12.8 18.8 0.54 10.5 0.7 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52620.1 - 0.18 11.9 6.2 9 6.6 0.2 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDW52620.1 - 0.32 11.9 12.6 3.1 8.9 0.8 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Rad50_zn_hook PF04423.14 CDW52620.1 - 0.7 9.8 6.8 2.2 8.2 1.2 2.7 1 1 1 2 2 2 0 Rad50 zinc hook motif zf-RING_2 PF13639.6 CDW52620.1 - 0.76 10.2 5.9 0.4 11.0 0.6 3.2 2 0 0 2 2 2 0 Ring finger domain ANAPC3 PF12895.7 CDW52620.1 - 0.91 9.8 6.9 2.6 8.3 0.2 3.9 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Dynein_light PF01221.18 CDW52621.1 - 7e-22 77.5 0.3 7e-22 77.5 0.3 1.5 2 0 0 2 2 2 1 Dynein light chain type 1 DUF707 PF05212.12 CDW52621.1 - 0.033 13.4 0.4 0.046 13.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF707) DUF1925 PF09094.11 CDW52621.1 - 0.055 13.8 0.1 0.075 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1925) Mago_nashi PF02792.14 CDW52622.1 - 7.1e-59 198.0 0.3 1.9e-58 196.6 0.3 1.6 1 1 0 1 1 1 1 Mago nashi protein Motile_Sperm PF00635.26 CDW52623.1 - 1.2e-20 73.4 0.1 1.5e-20 73.1 0.1 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 CDW52623.1 - 0.083 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PDZ PF00595.24 CDW52624.1 - 6.6e-85 279.6 0.3 1e-12 48.2 0.0 7.4 7 0 0 7 7 7 7 PDZ domain PDZ_6 PF17820.1 CDW52624.1 - 6e-75 247.0 11.2 3.9e-12 45.8 0.1 7.5 7 0 0 7 7 7 7 PDZ domain PDZ_2 PF13180.6 CDW52624.1 - 1.1e-36 125.0 0.2 6.4e-05 23.2 0.0 7.5 7 0 0 7 7 7 7 PDZ domain Tricorn_PDZ PF14685.6 CDW52624.1 - 4.6e-10 39.3 3.7 0.22 11.5 0.0 6.1 4 1 2 6 6 6 3 Tricorn protease PDZ domain Tox-HDC PF15656.6 CDW52624.1 - 0.00085 19.5 0.1 0.0022 18.2 0.1 1.6 1 0 0 1 1 1 1 Toxin with a H, D/N and C signature GRASP55_65 PF04495.14 CDW52624.1 - 0.014 15.7 0.0 6.1 7.2 0.0 3.9 3 2 2 5 5 5 0 GRASP55/65 PDZ-like domain HSCB_C PF07743.13 CDW52625.1 - 5.2e-16 58.9 1.7 5.2e-16 58.9 1.7 1.5 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 CDW52625.1 - 4.1e-06 26.8 0.3 9.5e-06 25.6 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain RPA PF10134.9 CDW52625.1 - 0.0061 16.1 0.0 0.015 14.8 0.0 1.6 2 0 0 2 2 2 1 Replication initiator protein A AMOP PF03782.17 CDW52626.1 - 4.4e-42 143.6 10.8 7.5e-42 142.8 10.8 1.4 1 0 0 1 1 1 1 AMOP domain VWD PF00094.25 CDW52626.1 - 6.9e-19 68.7 1.2 1.3e-17 64.5 1.2 2.6 1 1 0 1 1 1 1 von Willebrand factor type D domain NIDO PF06119.14 CDW52626.1 - 1.2e-17 64.6 2.0 3.4e-17 63.2 2.0 1.8 1 0 0 1 1 1 1 Nidogen-like Sushi PF00084.20 CDW52626.1 - 3.7e-05 24.2 2.5 0.00012 22.6 2.5 2.0 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) adh_short PF00106.25 CDW52628.1 - 2e-13 50.3 0.0 1.1e-12 47.8 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW52628.1 - 2.2e-09 37.2 0.0 5.6e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Anp1 PF03452.14 CDW52628.1 - 0.046 13.1 0.0 2.2 7.7 0.0 2.8 2 1 0 2 2 2 0 Anp1 CK2S PF15011.6 CDW52629.1 - 6e-11 42.5 2.1 7.7e-11 42.1 2.1 1.1 1 0 0 1 1 1 1 Casein Kinase 2 substrate STAG PF08514.11 CDW52629.1 - 0.019 14.9 0.2 0.036 14.0 0.2 1.5 1 0 0 1 1 1 0 STAG domain Cas_Csy2 PF09614.10 CDW52629.1 - 0.11 11.8 0.2 0.13 11.6 0.2 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy2) zf-C2H2_4 PF13894.6 CDW52630.1 - 2.4e-07 31.0 34.9 0.019 15.8 0.5 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW52630.1 - 9.3e-06 25.9 24.0 0.0018 18.6 0.2 5.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 CDW52630.1 - 1.6e-05 25.1 37.9 0.0074 16.7 0.8 4.6 5 0 0 5 5 5 3 Zinc finger, C2H2 type Spt46 PF17734.1 CDW52630.1 - 6.8e-05 22.8 1.6 0.034 14.0 0.4 2.2 2 0 0 2 2 2 2 Spermatogenesis-associated protein 46 zf-C2H2_3rep PF18868.1 CDW52630.1 - 0.0036 18.0 10.5 0.028 15.1 0.0 3.8 1 1 2 3 3 3 1 Zinc finger C2H2-type, 3 repeats DUF3268 PF11672.8 CDW52630.1 - 0.045 14.1 1.2 0.045 14.1 1.2 2.4 2 1 0 2 2 2 0 zinc-finger-containing domain zf-CSL PF05207.13 CDW52630.1 - 0.26 11.1 10.8 0.38 10.5 3.4 2.5 1 1 1 2 2 2 0 CSL zinc finger zf-C2H2_11 PF16622.5 CDW52630.1 - 1.2 9.0 0.0 1.2 9.0 0.0 4.3 4 0 0 4 4 4 0 zinc-finger C2H2-type zf_C2H2_ZHX PF18387.1 CDW52630.1 - 4.3 7.1 24.6 1.9 8.2 3.6 4.7 3 1 2 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain A2L_zn_ribbon PF08792.10 CDW52630.1 - 4.4 7.1 14.5 5.3 6.9 0.1 3.8 4 0 0 4 4 4 0 A2L zinc ribbon domain Ribonuc_2-5A PF06479.12 CDW52631.1 - 6.8e-40 136.2 0.0 2.8e-39 134.2 0.1 2.0 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase PF00069.25 CDW52631.1 - 3.4e-35 121.7 0.0 1.3e-22 80.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52631.1 - 2e-19 69.9 0.0 3.3e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW52631.1 - 1.5e-06 27.3 0.0 0.00048 19.0 0.0 2.1 2 0 0 2 2 2 2 Fungal protein kinase PQQ PF01011.21 CDW52631.1 - 2.8e-06 27.0 0.1 0.51 10.4 0.0 3.9 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_2 PF13360.6 CDW52631.1 - 8.8e-06 25.5 0.0 0.00062 19.4 0.0 2.5 2 0 0 2 2 2 1 PQQ-like domain HSBP1 PF06825.12 CDW52632.1 - 5e-05 23.1 0.1 8.8e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 Heat shock factor binding protein 1 WASH_WAHD PF11945.8 CDW52632.1 - 0.00036 20.2 0.1 0.0044 16.6 0.1 2.2 1 1 0 1 1 1 1 WAHD domain of WASH complex P4Ha_N PF08336.11 CDW52632.1 - 0.023 14.7 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Matrilin_ccoil PF10393.9 CDW52632.1 - 0.055 13.3 0.2 0.12 12.2 0.2 1.6 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF1664 PF07889.12 CDW52632.1 - 0.2 11.7 0.0 0.39 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CAP_N PF01213.19 CDW52632.1 - 0.41 10.1 3.9 0.99 8.8 2.9 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal COesterase PF00135.28 CDW52633.1 - 5e-119 398.5 0.0 6.4e-119 398.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Orf78 PF06024.12 CDW52633.1 - 0.15 12.4 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) EGF PF00008.27 CDW52634.1 - 4.6e-47 157.9 184.9 6.2e-07 29.6 7.6 13.7 13 0 0 13 13 13 13 EGF-like domain EGF_CA PF07645.15 CDW52634.1 - 1.3e-35 121.3 195.2 1.5e-08 34.7 14.2 13.7 8 4 5 13 13 13 9 Calcium-binding EGF domain EGF_2 PF07974.13 CDW52634.1 - 3e-29 101.1 240.1 1.5e-05 25.2 9.5 14.3 14 0 0 14 14 14 13 EGF-like domain EGF_3 PF12947.7 CDW52634.1 - 3.6e-19 68.6 187.8 0.00056 20.1 12.9 14.5 14 0 0 14 14 14 10 EGF domain hEGF PF12661.7 CDW52634.1 - 1.5e-14 54.0 178.8 0.048 14.3 9.4 14.9 13 1 0 13 13 13 11 Human growth factor-like EGF cEGF PF12662.7 CDW52634.1 - 2.1e-08 34.0 116.6 0.00058 19.7 5.6 13.6 13 0 0 13 13 13 11 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 CDW52634.1 - 0.00033 20.9 169.1 0.00092 19.5 5.0 13.6 11 2 2 13 13 13 7 Pvs28 EGF domain FXa_inhibition PF14670.6 CDW52634.1 - 0.012 15.9 6.7 0.012 15.9 6.7 14.2 9 2 5 14 14 14 0 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 CDW52634.1 - 0.013 15.7 174.5 0.84 9.8 3.0 14.4 5 2 9 14 14 14 0 Laminin EGF domain Peptidase_C48 PF02902.19 CDW52635.1 - 7.1e-16 58.7 0.4 1.6e-14 54.3 0.4 2.1 1 1 1 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain ARS2 PF04959.13 CDW52636.1 - 2e-55 188.2 3.1 2e-55 188.2 3.1 1.8 2 0 0 2 2 2 1 Arsenite-resistance protein 2 DUF3546 PF12066.8 CDW52636.1 - 2.2e-40 137.2 7.9 7.8e-40 135.5 7.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) RRM_1 PF00076.22 CDW52636.1 - 6e-05 22.8 0.0 0.00017 21.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EGF PF00008.27 CDW52637.1 - 1.2e-41 140.6 164.0 9.5e-08 32.2 9.4 10.9 11 0 0 11 11 11 10 EGF-like domain EGF_CA PF07645.15 CDW52637.1 - 2e-26 91.9 173.6 6.7e-08 32.6 13.6 10.6 6 2 4 10 10 10 9 Calcium-binding EGF domain hEGF PF12661.7 CDW52637.1 - 1.4e-21 76.3 133.0 0.00061 20.3 5.9 12.0 11 1 0 11 11 11 9 Human growth factor-like EGF EGF_2 PF07974.13 CDW52637.1 - 6.7e-18 64.8 177.8 0.0014 18.9 12.5 10.5 10 0 0 10 10 10 9 EGF-like domain FXa_inhibition PF14670.6 CDW52637.1 - 1.8e-08 34.5 144.0 0.019 15.3 8.2 10.6 5 1 4 10 10 10 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW52637.1 - 4.7e-06 26.7 158.8 0.0018 18.4 5.5 11.4 8 2 2 10 10 10 7 EGF domain cEGF PF12662.7 CDW52637.1 - 0.007 16.3 2.8 0.007 16.3 2.8 12.7 11 2 0 11 11 11 4 Complement Clr-like EGF-like RNase_PH PF01138.21 CDW52638.1 - 5.6e-39 133.7 0.0 1.2e-20 74.3 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDW52638.1 - 3.9e-14 52.4 0.3 1e-06 28.6 0.0 2.6 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 PNPase PF03726.14 CDW52638.1 - 0.00069 20.1 0.7 0.0014 19.1 0.7 1.5 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain S1 PF00575.23 CDW52638.1 - 0.028 14.8 0.0 0.075 13.4 0.0 1.8 1 0 0 1 1 1 0 S1 RNA binding domain KH_1 PF00013.29 CDW52638.1 - 0.035 13.9 0.0 0.16 11.8 0.0 2.2 1 0 0 1 1 1 0 KH domain SH2 PF00017.24 CDW52639.1 - 0.0003 20.8 1.5 1.7 8.8 0.0 4.8 5 1 0 5 5 5 2 SH2 domain Tau95 PF09734.9 CDW52640.1 - 5.4e-27 95.3 0.3 1.2e-26 94.1 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 CDW52640.1 - 3.3e-09 37.0 0.0 8.2e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Tau95 Triple barrel domain Hormone_recep PF00104.30 CDW52642.1 - 4.9e-30 104.7 0.0 1e-29 103.6 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 CDW52642.1 - 6.8e-26 90.5 20.7 1.4e-20 73.5 14.5 2.6 1 1 1 2 2 2 2 Zinc finger, C4 type (two domains) Sec8_exocyst PF04048.14 CDW52643.1 - 2.5e-10 40.4 1.1 3.1e-10 40.1 1.1 1.2 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain DUF1978 PF09321.10 CDW52643.1 - 0.0033 16.8 1.3 0.0037 16.6 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1978) Rab_bind PF16704.5 CDW52643.1 - 0.0066 16.5 0.3 0.018 15.0 0.1 1.8 2 0 0 2 2 2 1 Rab binding domain COG2 PF06148.11 CDW52643.1 - 0.14 12.2 4.1 0.22 11.6 4.1 1.3 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF2451 PF10474.9 CDW52644.1 - 0.00051 19.9 0.0 0.11 12.2 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function C-terminus (DUF2451) SMC_N PF02463.19 CDW52645.1 - 2.8e-60 203.5 1.0 3.9e-60 203.0 1.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDW52645.1 - 2.1e-11 44.7 16.8 9.4e-10 39.3 16.8 2.6 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 CDW52645.1 - 1.2e-10 41.7 2.5 0.00025 20.9 0.1 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDW52645.1 - 3.9e-10 40.0 0.0 7e-10 39.2 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain SlyX PF04102.12 CDW52645.1 - 5.6e-06 26.9 2.9 0.00068 20.2 0.6 3.1 3 0 0 3 3 2 1 SlyX ABC_tran PF00005.27 CDW52645.1 - 8.8e-06 26.3 1.8 0.0076 16.8 0.1 3.3 3 1 0 3 3 3 2 ABC transporter AAA_29 PF13555.6 CDW52645.1 - 0.00014 21.5 0.1 0.00075 19.2 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain Atg14 PF10186.9 CDW52645.1 - 0.00054 19.2 7.6 0.00054 19.2 7.6 2.2 2 1 0 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 GAS PF13851.6 CDW52645.1 - 0.0011 18.4 3.0 0.0011 18.4 3.0 2.8 3 0 0 3 3 3 1 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 CDW52645.1 - 0.0018 17.3 4.4 0.0018 17.3 4.4 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF812) DUF4337 PF14235.6 CDW52645.1 - 0.02 15.0 0.8 0.02 15.0 0.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) SOG2 PF10428.9 CDW52645.1 - 0.029 13.6 0.6 0.046 12.9 0.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Med9 PF07544.13 CDW52645.1 - 0.033 14.3 4.8 0.04 14.0 1.3 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DivIC PF04977.15 CDW52645.1 - 0.034 13.9 3.2 0.12 12.1 0.8 2.8 1 1 1 2 2 2 0 Septum formation initiator LPP PF04728.13 CDW52645.1 - 0.48 10.9 2.7 1 9.8 0.2 2.8 3 0 0 3 3 3 0 Lipoprotein leucine-zipper GrpE PF01025.19 CDW52645.1 - 0.58 9.8 11.9 0.2 11.3 3.8 2.9 3 0 0 3 3 3 0 GrpE DUF1664 PF07889.12 CDW52645.1 - 2 8.5 6.9 2.4 8.2 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) P4Ha_N PF08336.11 CDW52645.1 - 2.1 8.4 6.2 0.29 11.1 0.7 2.3 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TMPIT PF07851.13 CDW52645.1 - 2.3 7.4 13.2 2.1 7.5 4.3 2.3 1 1 0 2 2 2 0 TMPIT-like protein ATG16 PF08614.11 CDW52645.1 - 2.6 8.2 14.7 8 6.6 14.7 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Prefoldin_2 PF01920.20 CDW52645.1 - 3.4 7.7 15.6 2.2 8.3 4.5 2.7 2 0 0 2 2 2 0 Prefoldin subunit DUF16 PF01519.16 CDW52645.1 - 3.8 8.1 10.5 1.1 9.7 1.9 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 PCRF PF03462.18 CDW52645.1 - 5.8 6.7 10.7 0.9 9.4 3.7 2.6 3 0 0 3 3 3 0 PCRF domain DUF4140 PF13600.6 CDW52645.1 - 5.9 7.4 8.6 4.6 7.7 1.2 3.2 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) IPP-2 PF04979.14 CDW52645.1 - 6.6 7.5 7.0 2.3 8.9 0.2 2.6 2 0 0 2 2 2 0 Protein phosphatase inhibitor 2 (IPP-2) cNMP_binding PF00027.29 CDW52646.1 - 3.5e-17 62.2 0.0 7.3e-17 61.2 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CLZ PF16526.5 CDW52646.1 - 0.0024 18.2 4.2 0.0046 17.3 4.2 1.5 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SPT16 PF08644.11 CDW52646.1 - 0.093 12.9 0.3 5 7.3 0.5 2.5 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) Complex1_51K PF01512.17 CDW52647.1 - 1.7e-49 167.6 0.0 2.9e-49 166.9 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CDW52647.1 - 2.8e-27 94.6 0.4 8.9e-27 93.0 0.1 2.0 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CDW52647.1 - 5.9e-07 29.3 0.0 1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 SLBB domain Fer4_10 PF13237.6 CDW52647.1 - 0.0015 18.6 0.4 0.0052 16.9 0.4 1.9 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDW52647.1 - 0.084 13.0 2.5 0.27 11.4 2.5 1.9 1 0 0 1 1 1 0 4Fe-4S binding domain Pkinase PF00069.25 CDW52648.1 - 3.7e-21 75.7 0.0 7.8e-21 74.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 CDW52648.1 - 2.3e-10 40.9 16.2 0.00016 22.3 0.4 5.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 CDW52648.1 - 1.1e-09 37.9 0.0 2.4e-09 36.9 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 CDW52648.1 - 0.00061 19.8 0.9 7.2 7.2 0.1 5.2 5 0 0 5 5 5 1 HEAT repeat ANAPC4_WD40 PF12894.7 CDW52648.1 - 0.065 13.5 0.1 3.4 8.0 0.1 3.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DEAD PF00270.29 CDW52649.1 - 5.6e-41 140.2 0.8 8.8e-41 139.6 0.3 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW52649.1 - 1.2e-32 112.6 0.9 5.5e-32 110.4 0.3 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW52649.1 - 2.4e-05 24.4 0.0 5.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDW52649.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ERCC3_RAD25_C PF16203.5 CDW52649.1 - 0.018 14.3 0.4 0.03 13.5 0.4 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase tRNA-synt_1b PF00579.25 CDW52649.1 - 0.034 13.5 0.0 0.06 12.7 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) CMS1 PF14617.6 CDW52649.1 - 0.034 13.5 0.1 0.083 12.2 0.0 1.6 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 CDW52649.1 - 0.05 14.0 0.0 0.089 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 CDW52649.1 - 0.077 12.8 0.1 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Helicase Ribophorin_II PF05817.14 CDW52650.1 - 1e-67 229.2 0.9 1.3e-67 228.8 0.9 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II AvrM_N PF18247.1 CDW52650.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain SNF2_N PF00176.23 CDW52651.1 - 4.5e-58 196.7 0.0 1.1e-57 195.3 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW52651.1 - 1.6e-13 50.9 0.0 3.4e-11 43.5 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW52651.1 - 2.5e-09 37.4 0.0 5.1e-08 33.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CDW52651.1 - 0.00025 20.8 0.0 0.00056 19.7 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DEAD PF00270.29 CDW52651.1 - 0.001 18.9 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 CDW52651.1 - 0.0012 18.1 0.1 0.0042 16.3 0.0 1.9 2 1 1 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 FARP PF01581.16 CDW52652.1 - 3.4e-09 35.6 27.1 0.52 11.0 0.1 6.4 6 0 0 6 6 6 6 FMRFamide related peptide family Kinesin PF00225.23 CDW52653.1 - 2.1e-92 309.6 0.6 2.4e-91 306.1 0.6 2.0 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDW52653.1 - 1.5e-22 80.1 0.0 3.4e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Abhydro_lipase PF04083.16 CDW52654.1 - 6.7e-17 60.8 0.0 1.4e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CDW52654.1 - 1.8e-12 47.4 0.0 7.9e-12 45.4 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDW52654.1 - 0.0009 18.6 0.0 0.0017 17.7 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDW52654.1 - 0.091 13.4 0.0 0.13 12.9 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.25 CDW52656.1 - 1.5e-60 204.8 0.0 1.1e-35 123.3 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52656.1 - 2.2e-27 96.0 0.0 2.1e-14 53.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase MyTH4 PF00784.17 CDW52658.1 - 3.7e-31 107.8 0.2 7.5e-30 103.6 0.0 2.9 2 0 0 2 2 2 1 MyTH4 domain RhoGAP PF00620.27 CDW52658.1 - 3.8e-30 104.7 0.0 1.6e-29 102.7 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain WW PF00397.26 CDW52658.1 - 3.4e-08 33.4 5.5 6.4e-05 23.0 3.0 2.7 2 0 0 2 2 2 2 WW domain NAPRTase_N PF17767.1 CDW52659.1 - 9.9e-31 106.7 0.0 3e-30 105.2 0.0 1.9 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase_C PF17956.1 CDW52659.1 - 1.1e-27 96.6 0.0 1.9e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 CDW52659.1 - 6.5e-07 29.2 0.0 0.022 14.4 0.0 2.2 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family Glyco_hydro_31 PF01055.26 CDW52660.1 - 1.7e-138 462.5 0.1 2.2e-138 462.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CDW52660.1 - 8.2e-17 61.5 0.0 1.5e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 CDW52660.1 - 3.8e-08 33.1 4.1 7.1e-08 32.2 4.1 1.5 1 0 0 1 1 1 1 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.6 CDW52660.1 - 2.3e-06 27.8 0.7 7e-06 26.3 0.3 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 CDW52660.1 - 0.00036 20.8 0.0 0.001 19.3 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) RRM_1 PF00076.22 CDW52661.1 - 7e-61 202.0 0.0 4.2e-20 71.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW52661.1 - 7.5e-10 38.5 0.0 7.6e-05 22.3 0.0 2.9 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW52661.1 - 0.00024 20.9 0.0 0.61 10.0 0.0 3.0 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 CDW52661.1 - 0.011 15.7 0.0 7.9 6.6 0.0 2.6 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 CDW52661.1 - 0.022 14.9 0.0 11 6.3 0.0 2.8 2 1 0 2 2 2 0 RNA recognition motif Glyoxalase PF00903.25 CDW52663.1 - 4e-11 43.2 0.0 0.00038 20.6 0.0 2.8 2 1 1 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.6 CDW52663.1 - 0.002 18.2 0.0 1.8 8.7 0.0 2.4 2 0 0 2 2 2 2 CppA N-terminal Glyoxalase_2 PF12681.7 CDW52663.1 - 0.029 14.3 0.0 0.55 10.2 0.0 2.5 3 0 0 3 3 3 0 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CDW52663.1 - 0.061 14.1 0.0 0.72 10.7 0.0 2.5 2 1 0 2 2 2 0 Glyoxalase-like domain Ribosomal_L39 PF00832.20 CDW52664.1 - 3.3e-21 74.6 12.1 6.8e-21 73.6 12.1 1.6 1 0 0 1 1 1 1 Ribosomal L39 protein CHCH PF06747.13 CDW52664.1 - 7.8e-05 22.7 3.3 7.8e-05 22.7 3.3 2.0 2 0 0 2 2 2 1 CHCH domain MTCP1 PF08991.10 CDW52664.1 - 0.081 13.2 1.4 0.16 12.2 1.4 1.5 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type CX9C PF16860.5 CDW52664.1 - 0.62 10.1 4.3 5.2 7.2 2.1 2.4 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, V-SNARE_C PF12352.8 CDW52665.1 - 4e-12 46.2 3.1 4e-12 46.2 3.1 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 CDW52665.1 - 4.1e-10 39.9 3.8 4.1e-10 39.9 3.8 2.3 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 CDW52665.1 - 0.00015 21.6 1.4 0.00015 21.6 1.4 2.5 2 2 0 2 2 2 1 Sec20 CCDC-167 PF15188.6 CDW52665.1 - 0.00097 19.4 11.3 0.016 15.5 5.1 2.6 2 1 0 2 2 2 2 Coiled-coil domain-containing protein 167 LMBR1 PF04791.16 CDW52665.1 - 0.021 13.8 3.2 0.025 13.5 3.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein TraF_2 PF13729.6 CDW52665.1 - 0.052 12.9 3.5 0.56 9.5 1.5 2.1 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein DUF812 PF05667.11 CDW52665.1 - 0.059 12.2 10.8 0.076 11.9 10.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4407 PF14362.6 CDW52665.1 - 0.061 12.7 8.9 0.19 11.0 8.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HisKA PF00512.25 CDW52665.1 - 0.08 13.0 12.3 2.1 8.5 0.5 3.6 2 1 1 3 3 3 0 His Kinase A (phospho-acceptor) domain GP3_package PF16677.5 CDW52665.1 - 0.2 11.8 2.0 11 6.2 0.2 2.3 2 0 0 2 2 2 0 DNA-packaging protein gp3 Peptidase_S46 PF10459.9 CDW52665.1 - 0.26 9.9 7.6 0.33 9.5 7.6 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF2730 PF10805.8 CDW52665.1 - 0.33 11.1 4.7 0.29 11.3 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Occludin_ELL PF07303.13 CDW52665.1 - 0.34 11.7 6.7 4.8 8.0 0.3 2.4 2 1 0 2 2 2 0 Occludin homology domain FUSC PF04632.12 CDW52665.1 - 0.7 8.4 3.4 2.8 6.4 3.3 1.8 1 1 0 1 1 1 0 Fusaric acid resistance protein family STAT_alpha PF01017.20 CDW52665.1 - 0.9 9.4 11.4 0.93 9.4 4.6 2.3 1 1 1 2 2 2 0 STAT protein, all-alpha domain OppC_N PF12911.7 CDW52665.1 - 0.92 9.5 3.3 1.5 8.8 3.3 1.3 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C CENP-F_leu_zip PF10473.9 CDW52665.1 - 1 9.4 14.1 0.42 10.6 9.8 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 CDW52665.1 - 1.6 8.8 17.4 0.68 10.0 4.5 2.6 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding LD_cluster2 PF18163.1 CDW52665.1 - 1.6 8.2 4.6 0.86 9.1 0.3 2.1 2 1 0 2 2 2 0 SLOG cluster2 APG6_N PF17675.1 CDW52665.1 - 2.6 8.6 15.8 14 6.2 10.8 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region Fez1 PF06818.15 CDW52665.1 - 3.1 8.2 13.2 8.4 6.8 13.2 1.7 1 1 0 1 1 1 0 Fez1 Synaptobrevin PF00957.21 CDW52665.1 - 6.4 6.6 8.1 4 7.3 0.1 3.1 2 1 1 3 3 3 0 Synaptobrevin MetOD2 PF18548.1 CDW52665.1 - 7.2 6.8 10.9 8.7 6.5 0.7 3.1 2 1 1 3 3 3 0 Metanogen output domain 2 DUF3450 PF11932.8 CDW52665.1 - 7.4 5.8 13.6 0.89 8.8 4.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4519 PF15012.6 CDW52665.1 - 8.2 6.7 6.0 15 5.9 2.8 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4519) DUF948 PF06103.11 CDW52665.1 - 8.2 6.8 15.5 13 6.1 0.2 4.0 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Rx_N PF18052.1 CDW52665.1 - 9.5 6.6 11.2 14 6.1 0.9 3.1 2 1 1 3 3 3 0 Rx N-terminal domain Nuc_sug_transp PF04142.15 CDW52666.1 - 5.5e-83 278.7 22.3 6.6e-83 278.5 22.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 CDW52666.1 - 3.1e-12 46.8 38.3 1.2e-06 28.7 12.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 CDW52666.1 - 0.00089 18.6 12.1 0.00089 18.6 12.1 2.2 1 1 1 2 2 2 1 Purine nucleobase transmembrane transport TPT PF03151.16 CDW52666.1 - 0.0055 16.1 4.4 0.0055 16.1 4.4 2.5 2 2 0 2 2 2 2 Triose-phosphate Transporter family CRT-like PF08627.10 CDW52666.1 - 0.21 10.5 20.5 0.008 15.2 8.3 2.7 2 1 1 3 3 3 0 CRT-like, chloroquine-resistance transporter-like MFS_5 PF05631.14 CDW52667.1 - 2.3e-95 319.5 18.3 1.3e-66 225.0 12.5 3.0 2 1 0 2 2 2 2 Sugar-tranasporters, 12 TM TFIID_20kDa PF03847.13 CDW52667.1 - 7.6e-19 68.0 1.2 1.5e-18 67.0 1.2 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A MFS_1 PF07690.16 CDW52667.1 - 1.7e-07 30.5 24.5 1.7e-07 30.5 24.5 3.7 3 1 0 3 3 3 1 Major Facilitator Superfamily CBFD_NFYB_HMF PF00808.23 CDW52667.1 - 2.5e-05 24.5 0.1 4.7e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDW52667.1 - 0.003 17.9 0.4 0.0055 17.1 0.4 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CDW52667.1 - 0.017 15.2 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Ribosomal_L26 PF16906.5 CDW52668.1 - 3.1e-39 133.3 4.8 4.2e-39 132.9 4.8 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 CDW52668.1 - 2.4e-05 24.1 2.1 0.0001 22.1 2.1 2.1 1 1 0 1 1 1 1 KOW motif zf-3CxxC_2 PF17180.4 CDW52669.1 - 1.6e-10 41.5 3.4 3.4e-10 40.5 3.4 1.6 1 0 0 1 1 1 1 Zinc-binding domain zf-CCHC_2 PF13696.6 CDW52669.1 - 5.4e-06 26.1 8.1 5.4e-06 26.1 8.1 2.4 2 0 0 2 2 2 1 Zinc knuckle UPF0515 PF15135.6 CDW52669.1 - 0.19 11.1 6.3 0.25 10.7 6.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 DUF761 PF05553.11 CDW52669.1 - 0.22 11.1 1.1 0.4 10.2 1.1 1.4 1 0 0 1 1 1 0 Cotton fibre expressed protein Mito_carr PF00153.27 CDW52670.1 - 6.3e-129 420.3 12.2 7.7e-22 77.0 0.0 6.3 6 0 0 6 6 6 6 Mitochondrial carrier protein Aph-1 PF06105.12 CDW52670.1 - 2.4e-25 89.3 14.5 5.2e-25 88.2 14.5 1.5 1 0 0 1 1 1 1 Aph-1 protein ISP1_C PF18161.1 CDW52670.1 - 0.0045 17.0 0.1 20 5.2 0.0 3.5 3 0 0 3 3 3 1 ISP1 C-terminal PPDFL PF15060.6 CDW52670.1 - 0.0051 17.3 0.4 6.4 7.3 0.0 2.6 2 0 0 2 2 2 2 Differentiation and proliferation regulator Erythro_esteras PF05139.14 CDW52670.1 - 0.031 14.1 0.1 9.6 5.9 0.0 2.2 2 0 0 2 2 2 0 Erythromycin esterase ISP3_C PF18045.1 CDW52670.1 - 0.048 13.5 0.0 27 4.7 0.0 3.1 3 0 0 3 3 3 0 ISP3 C-terminal Imm21 PF15589.6 CDW52670.1 - 0.049 13.7 0.0 15 5.6 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 21 DUF2207 PF09972.9 CDW52670.1 - 3.3 6.4 6.0 6 5.5 0.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Pyr_redox_2 PF07992.14 CDW52671.1 - 6.5e-13 48.6 0.0 5.3e-07 29.2 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW52671.1 - 5.4e-05 23.3 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CDW52671.1 - 0.0057 15.4 0.0 0.011 14.4 0.0 1.5 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 CDW52671.1 - 0.009 16.6 0.0 5.8 7.6 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDW52671.1 - 0.0091 16.0 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CDW52671.1 - 0.023 13.8 0.0 2.4 7.1 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Alba PF01918.21 CDW52672.1 - 1.4e-09 37.6 0.1 6.7e-09 35.5 0.0 2.0 1 1 1 2 2 2 1 Alba Rpp20 PF12328.8 CDW52672.1 - 6e-08 32.7 0.1 2.1e-07 31.0 0.1 2.0 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Armet PF10208.9 CDW52673.1 - 2.3e-56 189.8 2.4 2.5e-56 189.6 2.4 1.0 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding HeH PF12949.7 CDW52673.1 - 0.048 13.4 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 HeH/LEM domain CUB PF00431.20 CDW52674.1 - 1.9e-148 485.2 11.2 2.5e-33 114.7 0.1 5.2 5 0 0 5 5 5 5 CUB domain Astacin PF01400.24 CDW52674.1 - 6.7e-69 231.3 0.0 1.1e-68 230.6 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) FXa_inhibition PF14670.6 CDW52674.1 - 9.2e-19 67.4 31.7 2.1e-10 40.7 7.6 3.0 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 CDW52674.1 - 2.3e-11 43.7 31.8 1.8e-07 31.2 9.7 3.0 3 0 0 3 3 3 2 Calcium-binding EGF domain cEGF PF12662.7 CDW52674.1 - 4.7e-11 42.4 8.7 5.7e-05 23.0 2.0 3.2 2 0 0 2 2 2 2 Complement Clr-like EGF-like EGF PF00008.27 CDW52674.1 - 0.00032 20.9 19.5 0.013 15.8 7.5 3.1 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 CDW52674.1 - 0.00093 19.3 28.4 0.0044 17.2 8.5 2.9 2 0 0 2 2 2 2 EGF domain CUB_2 PF02408.20 CDW52674.1 - 0.0013 18.5 3.4 0.028 14.2 0.2 4.1 5 0 0 5 5 5 1 CUB-like domain hEGF PF12661.7 CDW52674.1 - 0.0015 19.0 17.0 0.3 11.8 5.2 3.3 2 0 0 2 2 2 2 Human growth factor-like EGF Reprolysin_4 PF13583.6 CDW52674.1 - 0.042 13.5 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CDW52674.1 - 0.073 12.9 0.4 0.86 9.4 0.2 2.1 1 1 0 2 2 2 0 Matrixin 7tm_1 PF00001.21 CDW52675.1 - 1e-48 166.0 22.4 1.3e-48 165.6 22.4 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW52675.1 - 9.4e-13 48.1 23.4 1.7e-12 47.3 23.4 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 CDW52675.1 - 9e-09 35.5 14.9 1.8e-08 34.5 14.9 1.4 1 0 0 1 1 1 1 Olfactory receptor Spem1 PF15670.5 CDW52675.1 - 6.2 6.3 5.6 0.99 8.9 1.0 1.9 3 0 0 3 3 3 0 Spermatid maturation protein 1 MFS_1 PF07690.16 CDW52676.1 - 2.9e-43 148.2 43.1 1.6e-26 93.1 6.2 2.6 2 1 1 3 3 3 3 Major Facilitator Superfamily Kunitz_BPTI PF00014.23 CDW52677.1 - 4e-257 830.7 132.8 3.9e-17 62.2 0.3 16.6 16 0 0 16 16 16 16 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 CDW52677.1 - 3.8e-112 366.5 201.2 1.5e-10 41.2 6.7 14.4 13 0 0 13 13 13 13 Lustrin, cysteine-rich repeated domain Exo_endo_phos PF03372.23 CDW52678.1 - 2.8e-12 46.6 2.7 8.8e-12 45.0 2.7 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PI-PLC-X PF00388.19 CDW52679.1 - 2.4e-60 202.3 0.7 5.7e-60 201.1 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CDW52679.1 - 9.6e-41 138.7 0.0 9.6e-41 138.7 0.0 2.6 4 0 0 4 4 4 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_14 PF17787.1 CDW52679.1 - 2.8e-25 88.7 2.6 4.7e-24 84.7 0.0 3.2 2 1 0 2 2 2 1 PH domain EF-hand_like PF09279.11 CDW52679.1 - 2.2e-09 37.7 0.0 2.2e-09 37.7 0.0 3.9 4 0 0 4 4 4 1 Phosphoinositide-specific phospholipase C, efhand-like DUF1154 PF06631.11 CDW52679.1 - 3e-09 36.7 9.5 3e-09 36.7 9.5 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF1154) C2 PF00168.30 CDW52679.1 - 9.1e-07 29.1 0.0 2.3e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 C2 domain Aha1_N PF09229.11 CDW52680.1 - 5.2e-38 130.4 0.6 1e-37 129.4 0.6 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 CDW52680.1 - 4.2e-19 69.0 0.2 3.8e-18 65.9 0.2 2.2 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein HGTP_anticodon2 PF12745.7 CDW52680.1 - 0.00012 21.7 0.4 0.00019 21.1 0.4 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs Ribosomal_L12_N PF16320.5 CDW52680.1 - 0.069 12.9 0.1 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain DUF3641 PF12345.8 CDW52680.1 - 0.12 12.4 0.3 1.5 8.8 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3641) WD40 PF00400.32 CDW52681.1 - 3.5e-30 103.6 26.6 6.9e-05 23.6 0.1 11.6 12 0 0 12 12 12 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52681.1 - 6.2e-15 55.3 0.0 0.00017 21.8 0.0 5.2 5 0 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW52681.1 - 0.00063 19.7 0.0 2.6 7.9 0.1 3.7 4 1 1 5 5 5 2 Eukaryotic translation initiation factor eIF2A PQQ_3 PF13570.6 CDW52681.1 - 0.0038 17.7 0.0 0.063 13.8 0.0 3.0 2 0 0 2 2 2 1 PQQ-like domain Ge1_WD40 PF16529.5 CDW52681.1 - 0.0083 15.1 0.9 14 4.5 0.0 4.1 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WXG100 PF06013.12 CDW52681.1 - 0.012 15.8 0.4 0.028 14.7 0.4 1.5 1 0 0 1 1 1 0 Proteins of 100 residues with WXG Cytochrom_D1 PF02239.16 CDW52681.1 - 0.022 13.3 0.0 20 3.6 0.0 3.5 3 1 1 4 4 4 0 Cytochrome D1 heme domain PQQ PF01011.21 CDW52681.1 - 0.03 14.3 0.1 52 4.0 0.0 3.9 4 0 0 4 4 4 0 PQQ enzyme repeat nsp9 PF08710.10 CDW52681.1 - 0.11 12.9 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 nsp9 replicase MetallophosC PF16370.5 CDW52681.1 - 0.16 12.2 0.0 4.7 7.4 0.0 2.6 2 0 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase 2-oxoacid_dh PF00198.23 CDW52682.1 - 5.1e-73 245.4 0.0 6.5e-73 245.0 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDW52682.1 - 7.4e-18 64.2 0.0 1.4e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDW52682.1 - 5.5e-05 22.9 0.0 0.0018 18.0 0.0 2.6 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 CDW52682.1 - 0.0099 15.8 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 1 Glycine cleavage H-protein HlyD_D23 PF16576.5 CDW52682.1 - 0.037 13.2 0.0 0.081 12.1 0.0 1.6 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATG11 PF10377.9 CDW52682.1 - 0.12 12.4 0.0 0.37 10.8 0.0 1.8 1 1 0 1 1 1 0 Autophagy-related protein 11 SPRY PF00622.28 CDW52683.1 - 3.1e-16 59.6 0.0 4.9e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.16 CDW52683.1 - 0.0084 16.4 0.8 0.017 15.4 0.8 1.5 1 0 0 1 1 1 1 SOCS box GCP_C_terminal PF04130.13 CDW52684.1 - 4.4e-11 42.8 1.1 1.3e-10 41.3 1.1 1.8 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal CAP_GLY PF01302.25 CDW52685.1 - 1e-15 57.5 0.8 1.6e-15 56.8 0.8 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 CDW52685.1 - 0.002 18.5 5.9 0.19 12.2 0.6 3.2 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW52685.1 - 0.096 12.2 1.7 0.096 12.2 0.1 1.7 2 0 0 2 2 2 0 Leucine-rich repeat F-box-like PF12937.7 CDW52686.1 - 0.0018 18.1 0.0 0.0055 16.6 0.1 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CDW52686.1 - 0.039 13.9 0.0 0.098 12.6 0.0 1.7 1 0 0 1 1 1 0 F-box domain T4_deiodinase PF00837.17 CDW52686.1 - 0.15 11.3 0.0 0.69 9.2 0.0 1.9 1 1 0 1 1 1 0 Iodothyronine deiodinase adh_short PF00106.25 CDW52687.1 - 6e-30 104.2 0.0 8.1e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW52687.1 - 5.7e-16 58.8 0.0 7.9e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW52687.1 - 0.00053 19.9 0.0 0.0009 19.2 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CDW52687.1 - 0.0088 15.5 0.0 0.011 15.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family QVR PF17064.5 CDW52688.1 - 1.6e-06 28.2 5.0 2.4e-06 27.7 5.0 1.2 1 0 0 1 1 1 1 Sleepless protein DUF753 PF05444.12 CDW52688.1 - 0.021 14.8 7.3 1.4 8.9 1.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF753) zf-C4 PF00105.18 CDW52689.1 - 9.7e-28 96.4 14.9 9.7e-28 96.4 14.9 2.6 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW52689.1 - 4.4e-12 46.0 1.7 9e-12 45.0 1.7 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor EGF PF00008.27 CDW52690.1 - 4.2e-94 308.3 378.5 1.2e-08 35.0 6.5 28.2 28 0 0 28 28 28 24 EGF-like domain hEGF PF12661.7 CDW52690.1 - 4.5e-55 182.5 328.1 4.7e-05 23.9 5.9 28.8 27 0 0 27 27 27 22 Human growth factor-like EGF Laminin_G_2 PF02210.24 CDW52690.1 - 2.2e-32 112.3 0.2 4.1e-13 50.0 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 CDW52690.1 - 5.5e-29 101.0 0.0 2e-12 47.4 0.0 3.5 3 0 0 3 3 3 3 Laminin G domain EGF_CA PF07645.15 CDW52690.1 - 8.9e-20 70.6 87.4 1.1e-07 31.9 4.5 27.8 16 8 12 28 28 28 11 Calcium-binding EGF domain EGF_2 PF07974.13 CDW52690.1 - 1.2e-14 54.3 433.4 0.0019 18.5 8.3 27.1 27 0 0 27 27 27 19 EGF-like domain Insulin_TMD PF17870.1 CDW52690.1 - 0.019 15.0 1.1 0.034 14.2 1.1 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Zip PF02535.22 CDW52691.1 - 4.3e-58 197.1 6.7 5.2e-58 196.9 6.7 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter COesterase PF00135.28 CDW52692.1 - 6.1e-120 401.5 0.1 8.4e-120 401.0 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW52692.1 - 3.4e-08 33.6 0.0 8.5e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_C13 PF01650.18 CDW52693.1 - 1.5e-106 355.6 0.0 2.1e-106 355.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase C13 family Sec10 PF07393.11 CDW52694.1 - 1.9e-115 387.0 15.6 1.2e-64 219.1 3.3 3.1 1 1 1 2 2 2 2 Exocyst complex component Sec10 Ion_trans_2 PF07885.16 CDW52694.1 - 3.4e-22 78.2 13.3 2.1e-07 30.8 0.2 4.5 3 1 1 4 4 4 4 Ion channel EGF_3 PF12947.7 CDW52695.1 - 4e-53 177.3 239.8 1.9e-10 40.7 10.6 14.9 15 0 0 15 15 14 13 EGF domain G2F PF07474.12 CDW52695.1 - 1.2e-45 155.6 0.2 2.7e-45 154.4 0.0 1.7 2 0 0 2 2 2 1 G2F domain Ldl_recept_b PF00058.17 CDW52695.1 - 1.8e-23 82.7 1.8 1e-07 32.3 0.0 5.0 5 0 0 5 5 5 4 Low-density lipoprotein receptor repeat class B NIDO PF06119.14 CDW52695.1 - 4.2e-16 59.7 0.0 1.1e-15 58.3 0.0 1.8 1 0 0 1 1 1 1 Nidogen-like EGF PF00008.27 CDW52695.1 - 8.1e-16 58.0 205.1 0.00056 20.2 4.9 15.6 14 0 0 14 14 14 11 EGF-like domain cEGF PF12662.7 CDW52695.1 - 1.5e-12 47.2 139.3 0.00011 22.1 0.3 14.3 13 0 0 13 13 13 9 Complement Clr-like EGF-like EGF_CA PF07645.15 CDW52695.1 - 4.4e-09 36.4 21.8 1.1e-08 35.1 11.1 16.0 15 1 1 16 16 12 6 Calcium-binding EGF domain EGF_MSP1_1 PF12946.7 CDW52695.1 - 2.4e-06 27.5 173.9 0.0016 18.5 7.5 14.2 14 0 0 14 14 14 8 MSP1 EGF domain 1 DUF5050 PF16472.5 CDW52695.1 - 0.00013 21.3 0.0 0.00035 19.9 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5050) SGL PF08450.12 CDW52695.1 - 0.00019 21.1 0.1 2.5 7.6 0.0 3.4 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region FXa_inhibition PF14670.6 CDW52695.1 - 0.0015 18.8 9.0 0.0015 18.8 9.0 15.2 16 0 0 16 16 13 3 Coagulation Factor Xa inhibitory site Methyltransf_21 PF05050.12 CDW52696.1 - 0.0023 18.0 0.1 2.5 8.1 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase FkbM domain DUF4451 PF14616.6 CDW52696.1 - 0.022 14.9 0.2 0.1 12.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4451) PV-1 PF06637.11 CDW52696.1 - 0.17 10.7 1.6 0.18 10.6 0.1 1.6 2 0 0 2 2 2 0 PV-1 protein (PLVAP) DUF2773 PF10971.8 CDW52696.1 - 0.19 11.9 0.7 0.43 10.7 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2773) DUF747 PF05346.11 CDW52697.1 - 4.1e-103 345.2 22.6 5.6e-103 344.7 22.6 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family Complex1_30kDa PF00329.19 CDW52698.1 - 2.4e-42 144.4 0.0 3.4e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF4765 PF15962.5 CDW52698.1 - 0.22 9.4 0.0 0.26 9.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4765) NUDIX PF00293.28 CDW52699.1 - 5.8e-06 26.4 0.0 7.6e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain CagA PF03507.13 CDW52699.1 - 0.047 13.6 0.0 0.058 13.3 0.0 1.1 1 0 0 1 1 1 0 CagA exotoxin Requiem_N PF14051.6 CDW52700.1 - 1.2e-27 95.9 0.8 3.1e-27 94.6 0.8 1.7 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. Amnionless PF14828.6 CDW52700.1 - 1.6e-23 83.3 5.7 3.1e-23 82.3 5.5 1.6 2 0 0 2 2 2 1 Amnionless PHD PF00628.29 CDW52700.1 - 1.4e-09 37.6 33.7 1.2e-07 31.5 8.5 4.5 3 2 0 3 3 3 2 PHD-finger PHD_4 PF16866.5 CDW52700.1 - 0.00064 19.8 7.7 0.00064 19.8 7.7 4.3 3 1 1 4 4 4 1 PHD-finger PBP1_TM PF14812.6 CDW52700.1 - 0.83 10.1 4.5 1.8 9.0 4.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SH3_9 PF14604.6 CDW52701.1 - 5.8e-11 42.1 0.0 1.8e-10 40.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain O-FucT PF10250.9 CDW52701.1 - 7.6e-05 22.6 0.7 0.00027 20.8 0.7 1.9 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase SH3_1 PF00018.28 CDW52701.1 - 0.00034 20.2 0.0 0.0022 17.5 0.0 2.2 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 CDW52701.1 - 0.0047 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AMP_N PF05195.16 CDW52701.1 - 0.017 14.9 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Aminopeptidase P, N-terminal domain Calc_CGRP_IAPP PF00214.19 CDW52701.1 - 0.052 13.9 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family EF1G PF00647.19 CDW52702.1 - 6.3e-52 174.1 2.1 1.1e-51 173.4 1.0 1.9 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 CDW52702.1 - 3.1e-11 43.3 0.2 3.7e-10 39.9 0.1 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDW52702.1 - 7.3e-06 25.9 0.1 2.9e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDW52702.1 - 0.0023 18.1 0.2 0.0098 16.1 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_5 PF18485.1 CDW52702.1 - 0.1 13.0 0.2 0.33 11.3 0.2 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain NNMT_PNMT_TEMT PF01234.17 CDW52703.1 - 1.2e-67 227.9 0.0 1.4e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Pox_MCEL PF03291.16 CDW52703.1 - 0.00011 21.5 0.0 0.00014 21.1 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_23 PF13489.6 CDW52703.1 - 0.00027 20.8 0.0 0.00036 20.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW52703.1 - 0.0038 17.8 0.0 0.099 13.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW52703.1 - 0.014 16.1 0.0 0.48 11.2 0.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 CDW52703.1 - 0.043 14.6 0.0 0.11 13.3 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CDW52703.1 - 0.044 13.1 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Skp1_POZ PF03931.15 CDW52704.1 - 7.2e-11 42.1 0.0 1.5e-10 41.1 0.0 1.5 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Pox_MCEL PF03291.16 CDW52704.1 - 0.063 12.4 0.0 0.094 11.8 0.0 1.3 1 0 0 1 1 1 0 mRNA capping enzyme Motile_Sperm PF00635.26 CDW52705.1 - 7.9e-14 51.4 0.7 7.9e-14 51.4 0.7 1.6 2 0 0 2 2 2 1 MSP (Major sperm protein) domain DUF2828 PF11443.8 CDW52705.1 - 0.017 13.3 1.3 0.021 13.0 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3824 PF12868.7 CDW52705.1 - 0.049 14.3 12.6 0.094 13.4 12.6 1.5 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Viral_DNA_bi PF02236.17 CDW52705.1 - 0.14 12.4 0.2 12 6.1 0.1 2.4 1 1 1 2 2 2 0 Viral DNA-binding protein, all alpha domain CDC45 PF02724.14 CDW52705.1 - 0.16 10.2 1.8 0.13 10.5 1.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 CDW52705.1 - 2.1 7.0 4.9 2.4 6.8 4.9 1.1 1 0 0 1 1 1 0 Presenilin RNA_polI_A34 PF08208.11 CDW52705.1 - 3.5 7.7 21.4 6.4 6.8 21.4 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4746 PF15928.5 CDW52705.1 - 7.7 5.8 15.3 10 5.4 15.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Collagen PF01391.18 CDW52706.1 - 5.4e-23 80.5 78.0 7.6e-10 38.4 28.1 3.9 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW52706.1 - 3.7e-09 36.5 0.7 5e-09 36.1 0.7 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain NT-C2 PF10358.9 CDW52707.1 - 7e-20 71.2 0.0 1e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins ABC_tran PF00005.27 CDW52708.1 - 7.3e-48 162.6 0.1 1.4e-24 87.1 0.0 3.2 4 0 0 4 4 2 2 ABC transporter Rotamase_3 PF13616.6 CDW52708.1 - 3.2e-19 69.6 1.9 3.9e-19 69.3 0.0 2.1 2 0 0 2 2 1 1 PPIC-type PPIASE domain AAA_21 PF13304.6 CDW52708.1 - 4.1e-18 66.2 7.8 1.6e-05 24.9 0.0 5.0 4 1 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system Rotamase PF00639.21 CDW52708.1 - 1.8e-13 51.2 0.0 1.8e-13 51.2 0.0 2.6 3 0 0 3 3 1 1 PPIC-type PPIASE domain SMC_N PF02463.19 CDW52708.1 - 5.2e-11 42.4 1.4 0.0017 17.9 0.0 4.1 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDW52708.1 - 1.4e-08 34.8 0.1 0.0081 16.1 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 CDW52708.1 - 1.4e-06 28.2 5.5 0.022 14.5 0.3 3.4 3 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 CDW52708.1 - 1.6e-06 28.5 0.1 0.14 12.4 0.1 3.2 2 1 0 2 2 2 2 AAA domain ABC_tran_Xtn PF12848.7 CDW52708.1 - 1.6e-06 28.0 9.3 1.6e-06 28.0 9.3 2.7 3 0 0 3 3 2 1 ABC transporter AAA_16 PF13191.6 CDW52708.1 - 2.4e-06 28.0 0.0 0.073 13.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 CDW52708.1 - 3.1e-06 27.4 0.1 0.031 14.4 0.0 3.0 3 1 0 3 3 2 2 AAA domain AAA_14 PF13173.6 CDW52708.1 - 3.7e-06 27.0 0.0 0.1 12.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 CDW52708.1 - 4e-06 26.7 0.0 0.077 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CDW52708.1 - 5.3e-06 26.1 0.1 0.009 15.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain NACHT PF05729.12 CDW52708.1 - 1.6e-05 24.9 0.1 0.059 13.3 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA PF00004.29 CDW52708.1 - 2e-05 25.0 0.2 0.059 13.8 0.0 3.2 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CDW52708.1 - 2.6e-05 24.5 0.0 0.11 12.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CDW52708.1 - 2.6e-05 24.8 1.7 0.083 13.4 0.0 3.9 4 1 1 5 5 3 1 AAA domain MMR_HSR1 PF01926.23 CDW52708.1 - 3.7e-05 23.8 0.0 0.045 13.8 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 CDW52708.1 - 3.7e-05 24.3 12.5 0.015 15.8 0.0 3.9 3 1 0 3 3 3 2 AAA domain NTPase_1 PF03266.15 CDW52708.1 - 5.1e-05 23.3 0.1 0.28 11.1 0.0 3.1 3 0 0 3 3 2 2 NTPase ATPase_2 PF01637.18 CDW52708.1 - 7.5e-05 22.8 1.2 0.011 15.6 0.0 3.0 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 CDW52708.1 - 9.7e-05 22.2 0.0 0.44 10.2 0.1 3.1 2 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDW52708.1 - 0.00011 22.5 0.2 0.58 10.6 0.0 3.2 3 0 0 3 3 2 2 RNA helicase Rotamase_2 PF13145.6 CDW52708.1 - 0.00016 22.5 3.2 0.0072 17.2 0.0 3.0 3 0 0 3 3 2 1 PPIC-type PPIASE domain cobW PF02492.19 CDW52708.1 - 0.0003 20.4 0.2 0.036 13.6 0.0 3.0 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 CDW52708.1 - 0.00038 19.7 0.0 0.28 10.3 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain AAA_5 PF07728.14 CDW52708.1 - 0.00082 19.4 0.1 0.45 10.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Roc PF08477.13 CDW52708.1 - 0.0011 19.2 0.0 1.6 9.0 0.0 3.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 CDW52708.1 - 0.0019 17.8 0.3 2.8 7.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain SRP54 PF00448.22 CDW52708.1 - 0.0068 16.1 1.7 0.94 9.1 0.0 3.1 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain DUF87 PF01935.17 CDW52708.1 - 0.011 15.8 3.4 0.11 12.6 0.0 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain Septin PF00735.18 CDW52708.1 - 0.013 14.7 0.0 3.1 7.0 0.0 2.5 2 0 0 2 2 2 0 Septin TsaE PF02367.17 CDW52708.1 - 0.014 15.4 0.1 2.9 7.9 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 CDW52708.1 - 0.016 15.0 0.1 13 5.5 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 CDW52708.1 - 0.025 14.2 0.0 0.2 11.3 0.0 1.9 1 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 CDW52708.1 - 0.043 13.9 0.2 1.2 9.2 0.0 3.0 3 0 0 3 3 3 0 Dynamin family AAA_7 PF12775.7 CDW52708.1 - 0.055 13.0 5.2 1.9 8.0 0.0 2.9 3 1 0 3 3 2 0 P-loop containing dynein motor region CLP1_P PF16575.5 CDW52708.1 - 0.061 13.1 0.1 5 6.9 0.0 2.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SbcCD_C PF13558.6 CDW52708.1 - 0.076 13.3 1.1 3.2 8.0 0.4 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MobB PF03205.14 CDW52708.1 - 0.085 12.8 0.0 17 5.3 0.0 2.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FlgT_C PF16538.5 CDW52708.1 - 0.09 13.3 0.1 0.21 12.1 0.1 1.6 1 0 0 1 1 1 0 Flagellar assembly protein T, C-terminal domain T2SSE PF00437.20 CDW52708.1 - 0.1 11.6 0.2 11 5.0 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 CDW52708.1 - 0.12 12.7 0.4 5.1 7.4 0.0 2.8 2 1 0 2 2 2 0 AAA domain DUF3987 PF13148.6 CDW52708.1 - 0.36 9.8 5.5 9.3 5.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) ATP-synt_E PF05680.12 CDW52708.1 - 1.5 9.2 5.4 1.7 9.0 3.5 2.1 2 0 0 2 2 1 0 ATP synthase E chain Jnk-SapK_ap_N PF09744.9 CDW52708.1 - 2.1 8.6 11.2 0.34 11.1 3.3 2.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 AAA_17 PF13207.6 CDW52708.1 - 4.2 7.8 7.1 5 7.6 0.1 3.4 3 1 0 3 3 2 0 AAA domain O-FucT PF10250.9 CDW52709.1 - 2.2e-62 211.8 0.0 2.8e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase WEMBL PF05701.11 CDW52709.1 - 0.0072 15.1 0.6 0.0098 14.6 0.6 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light KxDL PF10241.9 CDW52709.1 - 0.018 15.3 1.0 0.044 14.1 1.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein Muted PF14942.6 CDW52709.1 - 0.037 14.4 2.1 0.067 13.5 2.1 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF1359 PF07097.11 CDW52709.1 - 0.15 12.3 1.3 0.3 11.4 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1359) DUF5089 PF17002.5 CDW52709.1 - 1.3 8.9 4.3 2 8.2 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) CTP_transf_like PF01467.26 CDW52710.1 - 3.5e-24 85.6 0.0 5.1e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF688 PF05097.12 CDW52710.1 - 0.17 11.0 1.0 0.25 10.5 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF688) Smg4_UPF3 PF03467.15 CDW52711.1 - 3.9e-19 69.3 0.0 3.9e-19 69.3 0.0 2.3 2 1 0 2 2 2 1 Smg-4/UPF3 family RRM_1 PF00076.22 CDW52711.1 - 0.00025 20.8 0.0 0.00059 19.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ctr PF04145.15 CDW52712.1 - 2.4e-35 122.4 5.5 2.9e-35 122.1 5.5 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Chromate_transp PF02417.15 CDW52712.1 - 0.29 11.3 9.0 8 6.6 9.0 2.0 1 1 0 1 1 1 0 Chromate transporter Na_K-ATPase PF00287.18 CDW52713.1 - 1.5e-62 211.4 1.7 1.8e-62 211.1 1.7 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Astacin PF01400.24 CDW52714.1 - 4.3e-90 300.5 0.0 1.2e-44 152.2 0.0 2.0 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) UPF0054 PF02130.17 CDW52714.1 - 0.0085 15.9 0.2 4.2 7.2 0.0 2.6 2 0 0 2 2 2 2 Uncharacterized protein family UPF0054 Peptidase_M10 PF00413.24 CDW52714.1 - 0.39 10.6 4.6 66 3.3 0.0 3.7 3 1 0 4 4 4 0 Matrixin DUF3267 PF11667.8 CDW52714.1 - 0.49 10.7 1.8 19 5.6 0.1 2.8 3 0 0 3 3 3 0 Putative zincin peptidase TSP_1 PF00090.19 CDW52715.1 - 8.5e-74 243.6 190.8 2.9e-11 43.4 7.2 13.0 13 0 0 13 13 13 10 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 CDW52715.1 - 4.8e-20 71.8 9.1 1.6e-17 63.8 2.9 7.6 6 2 0 7 7 7 2 ADAM cysteine-rich domain Reprolysin PF01421.19 CDW52715.1 - 8.6e-18 65.0 1.5 2.2e-17 63.7 1.5 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 CDW52715.1 - 3.8e-15 56.3 0.0 6.6e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 CDW52715.1 - 1.5e-06 28.6 1.6 1.5e-06 28.6 1.6 2.5 3 0 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 CDW52715.1 - 4.8e-06 27.1 0.2 9.3e-06 26.2 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CDW52715.1 - 0.00031 20.7 0.4 0.00089 19.2 0.4 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CDW52715.1 - 0.0012 18.6 0.1 0.0025 17.5 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Dynein_light PF01221.18 CDW52716.1 - 4.4e-27 94.2 0.0 5.2e-27 94.0 0.0 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 DUF1848 PF08902.11 CDW52716.1 - 0.049 13.3 0.0 0.061 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) SART-1 PF03343.13 CDW52716.1 - 0.25 9.9 0.0 0.3 9.6 0.0 1.1 1 0 0 1 1 1 0 SART-1 family Ribosomal_L19e PF01280.20 CDW52717.1 - 2.4e-65 219.0 13.7 2.4e-65 219.0 13.7 2.0 1 1 1 2 2 2 1 Ribosomal protein L19e IF4E PF01652.18 CDW52718.1 - 8.6e-24 84.1 0.1 1.2e-23 83.7 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E XPG_I PF00867.18 CDW52719.1 - 1e-22 80.3 0.0 2.2e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CDW52719.1 - 1.7e-18 66.9 0.0 4e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 CDW52719.1 - 0.18 12.4 0.0 0.64 10.7 0.0 2.0 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold EF-hand_13 PF17958.1 CDW52720.1 - 1.2e-25 89.1 0.1 4.1e-25 87.4 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 CDW52720.1 - 3.6e-17 62.6 2.8 2.3e-16 60.0 1.1 3.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 CDW52720.1 - 1.1e-05 24.6 0.1 0.00039 19.8 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 CDW52720.1 - 5.8e-05 22.7 0.7 0.0023 17.7 0.0 3.8 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 CDW52720.1 - 6.4e-05 22.2 1.4 0.0017 17.7 0.0 3.9 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 CDW52720.1 - 0.012 15.4 0.9 0.28 11.1 0.0 3.4 4 0 0 4 4 4 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW52720.1 - 0.048 14.0 2.6 2.6 8.4 0.4 2.9 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region vWF_A PF12450.8 CDW52721.1 - 0.032 14.2 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor HPS3_N PF14761.6 CDW52721.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Peptidase_M2 PF01401.18 CDW52722.1 - 5.2e-59 200.3 11.9 6.6e-59 200.0 11.9 1.0 1 0 0 1 1 1 1 Angiotensin-converting enzyme zf-C4 PF00105.18 CDW52722.1 - 0.061 13.8 1.8 0.14 12.7 1.8 1.6 1 0 0 1 1 1 0 Zinc finger, C4 type (two domains) Hist_deacetyl PF00850.19 CDW52724.1 - 5.3e-84 282.3 0.6 6.3e-84 282.1 0.1 1.3 2 0 0 2 2 2 1 Histone deacetylase domain NIL PF09383.10 CDW52724.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 NIL domain DegT_DnrJ_EryC1 PF01041.17 CDW52725.1 - 0.0013 18.1 0.0 0.0015 17.9 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF4819 PF16090.5 CDW52726.1 - 2.4e-20 72.4 0.1 4.9e-20 71.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4819) HMG_box PF00505.19 CDW52726.1 - 3.5e-16 59.4 0.8 6.7e-16 58.5 0.8 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW52726.1 - 5.2e-07 30.2 1.2 1.6e-06 28.6 1.2 1.9 1 0 0 1 1 1 1 HMG-box domain MBF1 PF08523.10 CDW52727.1 - 0.038 14.4 1.2 0.08 13.4 1.2 1.7 1 1 0 1 1 1 0 Multiprotein bridging factor 1 DUF3525 PF12039.8 CDW52727.1 - 0.12 11.0 0.0 0.12 11.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) Apyrase PF06079.11 CDW52728.1 - 5.1e-118 393.5 0.1 6.1e-118 393.3 0.1 1.0 1 0 0 1 1 1 1 Apyrase DUF3585 PF12130.8 CDW52729.1 - 3.4e-26 92.0 20.6 3.4e-26 92.0 20.6 2.3 2 0 0 2 2 2 1 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 CDW52729.1 - 1.1e-21 77.0 0.0 2.2e-21 76.0 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain NT-C2 PF10358.9 CDW52729.1 - 4.2e-12 46.0 0.0 8.9e-12 45.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins CAMSAP_CH PF11971.8 CDW52729.1 - 4.2e-06 26.5 0.0 1.2e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 CAMSAP CH domain TipAS PF07739.13 CDW52729.1 - 0.039 14.5 8.9 0.78 10.3 1.8 3.5 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain CH_2 PF06294.11 CDW52729.1 - 0.11 12.7 0.0 0.34 11.0 0.0 1.9 1 0 0 1 1 1 0 CH-like domain in sperm protein DUF5446 PF17522.2 CDW52729.1 - 0.4 10.9 5.4 1.6 8.9 5.4 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5446) DUF2433 PF10360.9 CDW52729.1 - 1.3 9.2 3.5 1.7 8.8 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2433) BTB PF00651.31 CDW52730.1 - 6e-09 36.1 0.1 5.5e-08 33.0 0.0 2.5 3 0 0 3 3 3 1 BTB/POZ domain WD40 PF00400.32 CDW52731.1 - 7.9e-34 115.1 14.4 1.8e-08 34.8 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52731.1 - 2.3e-10 40.6 0.2 0.0019 18.5 0.0 4.3 2 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CDW52731.1 - 0.017 15.6 0.0 10 6.8 0.0 2.9 2 0 0 2 2 2 0 PQQ-like domain PQQ_2 PF13360.6 CDW52731.1 - 0.024 14.2 0.3 0.3 10.7 0.4 2.1 1 1 0 1 1 1 0 PQQ-like domain Ge1_WD40 PF16529.5 CDW52731.1 - 0.029 13.3 0.1 7 5.5 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Collagen PF01391.18 CDW52732.1 - 5.7e-22 77.2 67.9 3.7e-08 33.0 22.7 4.3 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) SIX1_SD PF16878.5 CDW52733.1 - 1.1e-34 119.3 0.4 1.7e-34 118.7 0.4 1.3 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 CDW52733.1 - 7.1e-15 54.6 0.6 1.8e-14 53.3 0.1 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW52733.1 - 1.8e-13 50.1 0.5 4.3e-13 48.9 0.5 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 CDW52733.1 - 0.0019 17.6 0.1 0.0061 16.0 0.1 1.7 2 0 0 2 2 2 1 Homeodomain leucine-zipper encoding, Homez HTH_3 PF01381.22 CDW52733.1 - 0.0068 16.4 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix YdaS_antitoxin PF15943.5 CDW52733.1 - 0.02 14.8 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT ANAPC3 PF12895.7 CDW52733.1 - 0.034 14.4 0.4 0.047 13.9 0.4 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 HTH_26 PF13443.6 CDW52733.1 - 0.15 12.5 0.1 0.29 11.6 0.1 1.4 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain PBP PF01161.20 CDW52734.1 - 7.9e-18 65.0 0.0 9.3e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Glyco_hydro_47 PF01532.20 CDW52735.1 - 4.9e-266 882.8 1.0 3.5e-136 454.7 0.1 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 47 GlcNAc_2-epim PF07221.11 CDW52735.1 - 0.065 12.5 0.7 7.2 5.7 0.2 3.2 3 1 1 4 4 4 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Phage_min_tail PF05939.13 CDW52735.1 - 0.078 13.4 0.3 11 6.5 0.1 2.5 2 0 0 2 2 2 0 Phage minor tail protein DUF2517 PF10725.9 CDW52735.1 - 0.59 9.9 9.0 7.8 6.4 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2517) WD40 PF00400.32 CDW52736.1 - 3.5e-24 84.6 17.5 6.3e-07 30.0 0.1 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52736.1 - 1.3e-08 35.1 0.1 0.019 15.3 0.1 4.1 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Rad51 PF08423.11 CDW52736.1 - 3.2e-06 26.6 0.0 5.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Rad51 Nup160 PF11715.8 CDW52736.1 - 0.0053 15.5 1.9 1.8 7.1 0.1 3.7 1 1 3 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 CDW52736.1 - 0.068 12.5 0.1 3.6 6.8 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Ge1_WD40 PF16529.5 CDW52736.1 - 0.17 10.8 2.3 9.7 5.0 0.2 2.9 3 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ATG16 PF08614.11 CDW52737.1 - 3.2e-19 70.0 23.7 3.4e-19 69.9 23.7 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 CDW52737.1 - 0.02 14.7 9.2 0.02 14.7 9.2 2.6 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH V_ATPase_I PF01496.19 CDW52737.1 - 0.12 10.3 8.2 0.14 10.0 8.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF148 PF02520.17 CDW52737.1 - 0.2 11.8 9.0 0.084 13.0 6.4 1.7 1 1 0 1 1 1 0 Domain of unknown function DUF148 DUF4472 PF14739.6 CDW52737.1 - 0.29 11.9 18.1 3.2 8.5 4.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Cauli_AT PF03233.13 CDW52737.1 - 0.37 10.7 4.8 0.32 10.9 3.5 1.6 1 1 0 1 1 1 0 Aphid transmission protein SHE3 PF17078.5 CDW52737.1 - 0.39 10.4 19.1 7.4 6.2 19.3 2.1 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 YabA PF06156.13 CDW52737.1 - 1.5 9.5 18.1 2.8 8.6 6.5 2.7 1 1 2 3 3 3 0 Initiation control protein YabA Exonuc_VII_L PF02601.15 CDW52737.1 - 2.3 7.7 10.4 3.1 7.3 10.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Laminin_II PF06009.12 CDW52737.1 - 2.9 7.9 14.0 0.81 9.7 8.3 2.0 1 1 1 2 2 2 0 Laminin Domain II Spc24 PF08286.11 CDW52737.1 - 4.6 7.5 24.9 0.32 11.3 4.2 3.1 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 GAS PF13851.6 CDW52737.1 - 5.5 6.3 27.0 2.8 7.2 19.0 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TMPIT PF07851.13 CDW52737.1 - 6.7 5.9 9.1 8.4 5.5 9.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein APG6_N PF17675.1 CDW52737.1 - 7.5 7.1 32.7 21 5.6 19.4 2.4 1 1 2 3 3 3 0 Apg6 coiled-coil region Spc7 PF08317.11 CDW52737.1 - 7.7 5.3 23.4 0.22 10.4 11.5 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein KIAA1430 PF13879.6 CDW52737.1 - 8.2 7.3 13.6 16 6.3 12.3 2.1 1 1 1 2 2 2 0 KIAA1430 homologue NPV_P10 PF05531.12 CDW52737.1 - 8.9 6.9 7.6 1.7 9.2 3.0 2.1 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Bin3 PF06859.12 CDW52738.1 - 4.5e-34 117.3 0.0 1.1e-33 116.1 0.0 1.6 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_23 PF13489.6 CDW52738.1 - 1.2e-11 44.8 0.0 1.9e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW52738.1 - 6.9e-11 42.7 0.0 6.3e-07 30.0 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CDW52738.1 - 2.4e-10 41.1 0.0 0.00017 22.3 0.0 3.2 4 0 0 4 4 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 CDW52738.1 - 6.7e-10 39.0 0.0 2.6e-07 30.5 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CDW52738.1 - 3.4e-09 37.2 0.0 0.00041 20.9 0.0 3.0 3 0 0 3 3 3 2 Methyltransferase domain PrmA PF06325.13 CDW52738.1 - 3.1e-06 26.8 0.0 6.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 CDW52738.1 - 1.3e-05 25.0 0.0 2.8e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CDW52738.1 - 6e-05 22.6 0.0 0.00034 20.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 CDW52738.1 - 0.00014 21.2 0.0 0.17 11.2 0.0 2.2 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 CDW52738.1 - 0.0037 17.2 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CDW52738.1 - 0.01 15.2 0.0 0.047 13.0 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain Met_10 PF02475.16 CDW52738.1 - 0.044 13.5 0.0 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_4 PF02390.17 CDW52738.1 - 0.063 12.7 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.18 CDW52738.1 - 0.11 11.8 0.0 6.8 5.9 0.0 2.2 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family zf-CCCH PF00642.24 CDW52740.1 - 0.00014 21.7 8.4 0.0026 17.6 3.6 2.9 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 CDW52740.1 - 0.0034 17.8 7.4 0.31 11.6 1.0 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 CDW52740.1 - 0.0046 16.7 10.2 0.23 11.3 2.5 3.0 2 1 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 CDW52740.1 - 0.0056 16.9 0.9 0.01 16.0 0.9 1.4 1 0 0 1 1 1 1 Zinc-finger containing family Antifungal_prot PF11402.8 CDW52740.1 - 0.012 15.9 7.2 0.074 13.3 7.2 2.0 1 1 0 1 1 1 0 Antifungal protein RMI1_N PF08585.12 CDW52740.1 - 0.068 12.9 0.0 0.089 12.5 0.0 1.3 1 0 0 1 1 1 0 RecQ mediated genome instability protein zf_CCCH_4 PF18345.1 CDW52740.1 - 0.073 13.2 11.3 1.2 9.3 2.4 3.8 2 2 0 2 2 2 0 Zinc finger domain Torus PF16131.5 CDW52740.1 - 2.6 8.8 12.4 1.2 9.8 0.3 2.9 2 1 1 3 3 3 0 Torus domain dsrm PF00035.26 CDW52741.1 - 2.8e-15 56.7 0.1 0.0025 18.5 0.0 4.5 4 0 0 4 4 4 4 Double-stranded RNA binding motif DUF3385 PF11865.8 CDW52741.1 - 0.078 12.9 0.5 4.6 7.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) EcKinase PF02958.20 CDW52741.1 - 0.09 12.1 0.0 5.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Ecdysteroid kinase Arm PF00514.23 CDW52741.1 - 1.1 9.3 7.7 85 3.4 0.1 6.2 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat DUF4796 PF16044.5 CDW52742.1 - 8.8e-22 77.6 0.0 1.6e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) Occludin_ELL PF07303.13 CDW52742.1 - 0.014 16.1 0.0 0.048 14.4 0.0 1.9 2 0 0 2 2 2 0 Occludin homology domain HATPase_c_4 PF13749.6 CDW52742.1 - 0.051 13.7 0.1 0.17 12.1 0.1 1.9 2 0 0 2 2 2 0 Putative ATP-dependent DNA helicase recG C-terminal CENP-F_leu_zip PF10473.9 CDW52742.1 - 0.15 12.1 1.5 0.27 11.2 1.5 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IL7 PF01415.16 CDW52742.1 - 0.44 10.6 3.8 3.5 7.6 0.1 2.9 3 0 0 3 3 3 0 Interleukin 7/9 family WD40 PF00400.32 CDW52743.1 - 8.6e-21 73.9 9.8 1.3e-06 29.0 0.0 5.8 4 1 1 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW52743.1 - 1.8e-10 40.9 0.3 0.00055 20.2 0.1 4.1 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW52743.1 - 0.0048 15.9 0.0 3.5 6.5 0.0 2.8 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 CDW52743.1 - 0.05 12.5 0.0 2.8 6.8 0.0 2.9 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain SARAF PF06682.12 CDW52744.1 - 0.058 13.0 0.1 0.077 12.6 0.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF2615 PF11027.8 CDW52744.1 - 0.17 12.1 0.0 0.17 12.1 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2615) DUF2615 PF11027.8 CDW52745.1 - 1.1 9.4 0.0 1.1 9.4 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) DUF2615 PF11027.8 CDW52746.1 - 1.5 9.0 0.0 1.5 9.0 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) SARAF PF06682.12 CDW52746.1 - 7.5 6.1 6.3 35 3.9 6.3 1.8 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Kri1_C PF12936.7 CDW52748.1 - 1.8e-28 98.5 0.4 1.8e-28 98.5 0.4 4.2 3 0 0 3 3 3 1 KRI1-like family C-terminal Kri1 PF05178.12 CDW52748.1 - 2.4e-21 76.2 13.2 2.4e-21 76.2 13.2 5.6 3 2 1 4 4 4 1 KRI1-like family GET2 PF08690.10 CDW52749.1 - 7.6 6.1 5.8 13 5.4 5.8 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 EGF PF00008.27 CDW52750.1 - 1.5e-45 153.0 141.7 3.6e-09 36.8 3.6 11.3 10 1 0 10 10 10 9 EGF-like domain hEGF PF12661.7 CDW52750.1 - 4.7e-28 96.8 129.5 2.1e-06 28.1 3.7 12.0 12 0 0 12 12 12 8 Human growth factor-like EGF DSL PF01414.19 CDW52750.1 - 9e-21 73.9 6.7 9e-21 73.9 6.7 9.1 4 2 6 10 10 10 1 Delta serrate ligand EGF_2 PF07974.13 CDW52750.1 - 4.6e-08 33.3 174.8 0.004 17.5 8.5 11.7 11 0 0 11 11 11 7 EGF-like domain EGF_CA PF07645.15 CDW52750.1 - 0.0004 20.5 29.0 0.003 17.7 11.6 10.9 3 2 7 10 10 10 3 Calcium-binding EGF domain hDGE_amylase PF14701.6 CDW52751.1 - 6.2e-134 447.4 0.1 9.4e-134 446.8 0.1 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 CDW52751.1 - 6.1e-117 390.8 0.0 9.1e-117 390.2 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 CDW52751.1 - 9.9e-65 218.7 0.0 1.4e-64 218.2 0.0 1.2 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme Alpha-amylase PF00128.24 CDW52751.1 - 5e-05 23.0 0.0 0.0001 22.0 0.0 1.4 1 0 0 1 1 1 1 Alpha amylase, catalytic domain hGDE_N PF14699.6 CDW52751.1 - 0.00041 20.4 0.0 0.00084 19.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme BCAS2 PF05700.11 CDW52751.1 - 0.079 12.6 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) T6PP_N PF18572.1 CDW52752.1 - 3.5e-21 74.9 0.0 6.9e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DUF659 PF04937.15 CDW52752.1 - 0.097 12.5 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) CPBP PF02517.16 CDW52753.1 - 0.045 14.1 4.9 0.069 13.5 1.9 2.3 2 1 0 2 2 2 0 CPBP intramembrane metalloprotease IRK PF01007.20 CDW52753.1 - 0.62 9.9 7.8 0.12 12.2 2.4 1.9 1 1 1 2 2 2 0 Inward rectifier potassium channel transmembrane domain Sugar_tr PF00083.24 CDW52754.1 - 2.9e-70 237.4 19.4 3.5e-70 237.1 19.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW52754.1 - 1.1e-22 80.5 22.6 1.1e-22 80.5 22.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Metallophos PF00149.28 CDW52755.1 - 1.9e-37 129.8 0.0 2.4e-37 129.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW52755.1 - 1.3e-16 60.7 0.1 5.1e-16 58.8 0.1 2.0 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain EGF PF00008.27 CDW52756.1 - 1.3e-202 655.2 514.5 2.1e-09 37.5 6.5 36.0 35 0 0 35 35 34 34 EGF-like domain hEGF PF12661.7 CDW52756.1 - 2.2e-126 408.8 455.1 2e-07 31.4 3.4 38.3 37 0 0 37 37 35 33 Human growth factor-like EGF EGF_CA PF07645.15 CDW52756.1 - 1.4e-53 178.8 523.0 8.9e-10 38.6 9.0 36.0 19 10 17 36 36 31 21 Calcium-binding EGF domain EGF_2 PF07974.13 CDW52756.1 - 4.8e-48 161.2 612.0 0.0001 22.6 4.3 37.5 36 1 1 37 37 35 28 EGF-like domain Ank_2 PF12796.7 CDW52756.1 - 1.8e-30 105.3 4.9 2.1e-12 47.5 0.1 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Notch PF00066.17 CDW52756.1 - 1.5e-24 86.1 52.7 3.5e-12 46.6 13.3 20.7 22 3 2 24 24 6 3 LNR domain Ank_5 PF13857.6 CDW52756.1 - 4.2e-18 65.2 2.5 7.6e-07 29.3 0.1 4.5 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 CDW52756.1 - 2.2e-17 62.7 2.0 0.002 18.5 0.0 6.9 7 0 0 7 7 6 4 Ankyrin repeat Ank_4 PF13637.6 CDW52756.1 - 8.4e-17 61.3 1.6 6.5e-08 33.0 0.1 5.5 2 2 4 6 6 6 4 Ankyrin repeats (many copies) NOD PF06816.13 CDW52756.1 - 3.3e-15 55.4 0.6 5.4e-15 54.7 0.0 1.6 2 0 0 2 2 2 1 NOTCH protein Ank_3 PF13606.6 CDW52756.1 - 1.1e-12 47.0 0.7 0.081 13.5 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat NODP PF07684.12 CDW52756.1 - 8.8e-11 41.8 0.0 1.3e-09 38.1 0.0 3.3 1 0 0 1 1 1 1 NOTCH protein EGF_3 PF12947.7 CDW52756.1 - 0.0011 19.1 13.8 0.0016 18.6 4.6 37.0 32 5 5 37 37 34 16 EGF domain Arf PF00025.21 CDW52757.1 - 3.5e-52 176.4 0.7 4.3e-52 176.1 0.7 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW52757.1 - 1.1e-10 41.7 0.0 1.5e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDW52757.1 - 2.7e-07 30.1 0.4 0.00022 20.5 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CDW52757.1 - 4.9e-07 29.4 0.0 9.1e-07 28.5 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 CDW52757.1 - 4.2e-06 26.4 0.0 5.4e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CDW52757.1 - 7.3e-06 26.0 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW52757.1 - 0.00068 19.2 0.6 0.0047 16.5 0.6 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 CDW52757.1 - 0.0021 17.4 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 CDW52757.1 - 0.078 12.4 0.0 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein Dynamin_N PF00350.23 CDW52757.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Dynamin family AAA_18 PF13238.6 CDW52757.1 - 0.14 12.7 0.0 0.26 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain zf-C2H2 PF00096.26 CDW52758.1 - 2.6e-17 62.2 27.5 0.00013 22.2 0.5 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW52758.1 - 2.1e-14 53.2 27.4 5.6e-05 23.4 0.5 6.5 7 0 0 7 7 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW52758.1 - 1.2e-08 35.1 37.6 0.0096 16.7 0.4 5.5 6 0 0 6 6 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW52758.1 - 0.0099 15.9 30.6 0.067 13.2 0.4 5.7 5 1 0 5 5 5 3 C2H2-type zinc finger GATA PF00320.27 CDW52758.1 - 0.011 15.3 3.6 0.21 11.2 0.1 2.6 2 0 0 2 2 2 0 GATA zinc finger FliJ PF02050.16 CDW52758.1 - 0.026 14.8 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein zf-Di19 PF05605.12 CDW52758.1 - 0.026 14.8 2.5 0.026 14.8 2.5 4.0 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding TRAF6_Z2 PF18048.1 CDW52758.1 - 0.062 13.4 1.7 0.062 13.4 1.7 2.9 3 0 0 3 3 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_jaz PF12171.8 CDW52758.1 - 0.068 13.5 0.2 0.068 13.5 0.2 5.4 6 0 0 6 6 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 CDW52758.1 - 0.07 12.9 22.4 1.1 9.0 0.1 5.1 5 0 0 5 5 5 0 zinc-finger C2H2-type zf_UBZ PF18439.1 CDW52758.1 - 0.2 11.3 14.5 1 9.0 0.1 4.3 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 CDW52758.1 - 0.37 10.9 0.2 0.37 10.9 0.2 4.9 6 0 0 6 6 4 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 CDW52758.1 - 0.42 10.8 12.6 1.7 8.8 0.1 3.9 3 1 1 4 4 4 0 Zinc ribbon domain DZR PF12773.7 CDW52758.1 - 0.68 10.0 13.7 2.8 8.0 1.8 3.0 2 1 1 3 3 3 0 Double zinc ribbon zinc_ribbon_15 PF17032.5 CDW52758.1 - 0.74 10.6 10.5 7.4 7.4 4.7 3.2 2 1 1 3 3 3 0 zinc-ribbon family zf-C2H2_8 PF15909.5 CDW52758.1 - 0.79 10.1 7.0 0.52 10.7 2.1 2.5 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf_C2H2_13 PF18508.1 CDW52758.1 - 0.83 9.3 4.0 26 4.5 1.5 2.9 2 1 0 2 2 2 0 Zinc finger domain Nudix_N_2 PF14803.6 CDW52758.1 - 1.4 8.9 8.3 2.4 8.1 0.2 3.2 3 0 0 3 3 2 0 Nudix N-terminal zf-UBR PF02207.20 CDW52758.1 - 2.9 8.1 14.9 0.063 13.4 4.3 3.0 2 1 1 3 3 3 0 Putative zinc finger in N-recognin (UBR box) HypA PF01155.19 CDW52758.1 - 3.2 7.8 9.4 0.53 10.3 0.9 2.9 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_ZIC PF18366.1 CDW52758.1 - 3.5 7.8 12.3 2.4 8.3 0.1 3.9 2 1 2 4 4 4 0 Zic proteins zinc finger domain zf-C2H2_2 PF12756.7 CDW52758.1 - 3.6 8.0 27.9 3.3 8.1 1.3 5.5 2 2 4 6 6 6 0 C2H2 type zinc-finger (2 copies) Zn_ribbon_recom PF13408.6 CDW52758.1 - 9.3 6.8 15.6 3.3 8.3 1.7 3.4 4 0 0 4 4 4 0 Recombinase zinc beta ribbon domain Glyco_hydro_32N PF00251.20 CDW52759.1 - 0.078 12.5 0.3 0.13 11.8 0.3 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain CBM_14 PF01607.24 CDW52759.1 - 1.3 9.2 13.3 6.6 7.0 6.5 2.6 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain CBM_14 PF01607.24 CDW52760.1 - 0.00029 20.9 2.3 0.00029 20.9 2.3 2.3 2 1 0 2 2 2 1 Chitin binding Peritrophin-A domain CBM_14 PF01607.24 CDW52761.1 - 0.00016 21.8 3.0 0.00016 21.8 3.0 3.6 4 0 0 4 4 4 2 Chitin binding Peritrophin-A domain Zn_ribbon_recom PF13408.6 CDW52761.1 - 0.67 10.5 8.6 2.7 8.6 0.3 3.3 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Neur_chan_LBD PF02931.23 CDW52762.1 - 1.3e-12 47.6 2.4 3.5e-12 46.2 2.4 1.6 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain ShK PF01549.24 CDW52762.1 - 3.5e-06 27.4 9.3 6.5e-06 26.6 9.3 1.5 1 0 0 1 1 1 1 ShK domain-like TBCC PF07986.12 CDW52763.1 - 6e-31 106.7 9.1 8.4e-31 106.2 8.3 1.6 1 1 1 2 2 2 1 Tubulin binding cofactor C CAP_C PF08603.11 CDW52763.1 - 9.6e-06 25.3 1.7 1.2e-05 24.9 1.7 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal ATXN-1_C PF12547.8 CDW52763.1 - 0.42 11.0 0.3 0.42 11.0 0.3 1.9 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator zf-H2C2 PF09337.10 CDW52763.1 - 1.2 9.4 4.9 1.2 9.4 0.1 2.5 2 0 0 2 2 2 0 H2C2 zinc finger Astacin PF01400.24 CDW52764.1 - 8.3e-61 204.9 0.0 3.7e-39 134.3 0.0 2.2 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) ShK PF01549.24 CDW52764.1 - 6.7e-07 29.7 9.9 1.3e-06 28.8 9.9 1.5 1 0 0 1 1 1 1 ShK domain-like Peptidase_M10 PF00413.24 CDW52764.1 - 0.073 12.9 0.2 1.1 9.1 0.1 2.3 1 1 0 2 2 2 0 Matrixin Sec7 PF01369.20 CDW52765.1 - 1.1e-60 204.5 0.0 1.5e-60 204.1 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain IQ_SEC7_PH PF16453.5 CDW52765.1 - 4.8e-43 146.4 0.0 9.4e-43 145.5 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 CDW52765.1 - 0.017 15.0 0.0 0.058 13.2 0.0 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain PH PF00169.29 CDW52765.1 - 0.11 13.0 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 PH domain CRIM PF16978.5 CDW52766.1 - 3.5e-17 62.9 0.0 6.9e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1 PF05422.12 CDW52766.1 - 9.7e-05 23.0 2.5 0.0029 18.2 0.3 2.8 1 1 1 2 2 2 2 Stress-activated map kinase interacting protein 1 (SIN1) SmpA_OmlA PF04355.13 CDW52766.1 - 0.09 12.6 0.0 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 SmpA / OmlA family p450 PF00067.22 CDW52767.1 - 2.6e-98 329.8 0.2 3.3e-98 329.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 CcmD PF04995.14 CDW52767.1 - 0.087 12.9 1.1 0.24 11.5 1.1 1.8 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) RNA_pol_inhib PF16857.5 CDW52767.1 - 0.15 11.9 0.0 0.4 10.5 0.0 1.6 2 0 0 2 2 2 0 RNA polymerase inhibitor Peptidase_M24 PF00557.24 CDW52768.1 - 5.1e-19 68.8 0.1 6e-19 68.6 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Bac_DNA_binding PF00216.21 CDW52768.1 - 0.037 14.2 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 Bacterial DNA-binding protein DNA_pol3_delta2 PF13177.6 CDW52769.1 - 5.9e-10 39.2 0.1 1.3e-09 38.0 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CDW52769.1 - 4.6e-07 30.0 0.0 1.2e-06 28.6 0.0 1.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA PF00004.29 CDW52769.1 - 0.00021 21.7 0.0 0.00043 20.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW52769.1 - 0.0019 18.6 0.0 0.0057 17.1 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activ_2 PF14532.6 CDW52769.1 - 0.0027 17.8 0.2 0.49 10.5 0.1 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain DNA_pol3_delta PF06144.13 CDW52769.1 - 0.012 15.4 0.2 0.019 14.8 0.2 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 CDW52769.1 - 0.052 12.9 0.1 0.19 11.1 0.1 1.9 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 CDW52769.1 - 0.078 13.5 0.0 0.25 11.8 0.0 1.8 2 1 0 2 2 2 0 ABC transporter Rep_fac_C PF08542.11 CDW52769.1 - 0.078 13.4 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Replication factor C C-terminal domain S6PP PF05116.13 CDW52769.1 - 0.1 12.1 0.0 0.79 9.2 0.1 2.0 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase DUF815 PF05673.13 CDW52769.1 - 0.17 11.0 0.0 0.32 10.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Ost5 PF05251.12 CDW52770.1 - 0.066 13.5 0.3 0.066 13.5 0.3 1.8 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 Ins145_P3_rec PF08709.11 CDW52771.1 - 7.6e-67 224.6 0.1 2.8e-65 219.5 0.1 2.7 1 1 0 1 1 1 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.21 CDW52771.1 - 1e-57 194.8 15.0 3.2e-50 170.4 5.4 3.7 3 0 0 3 3 3 2 RIH domain MIR PF02815.19 CDW52771.1 - 6e-47 159.9 6.0 4.6e-46 157.0 2.6 2.5 2 0 0 2 2 2 1 MIR domain RIH_assoc PF08454.11 CDW52771.1 - 2.8e-31 107.4 9.5 2.4e-28 97.9 1.6 4.7 3 1 0 3 3 3 2 RyR and IP3R Homology associated Ion_trans PF00520.31 CDW52771.1 - 2.9e-17 62.7 4.6 5.1e-17 61.9 4.6 1.4 1 0 0 1 1 1 1 Ion transport protein POT1 PF02765.17 CDW52771.1 - 0.11 12.4 0.0 0.39 10.5 0.0 1.9 1 0 0 1 1 1 0 Telomeric single stranded DNA binding POT1/CDC13 DUF2722 PF10846.8 CDW52772.1 - 0.0011 18.0 8.6 0.0011 18.0 8.6 2.9 3 1 0 3 3 3 2 Protein of unknown function (DUF2722) 7TM_GPCR_Srsx PF10320.9 CDW52773.1 - 4.3e-10 39.4 13.7 6e-10 38.9 13.7 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 CDW52773.1 - 0.002 17.7 5.2 0.002 17.7 5.2 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF2417 PF10329.9 CDW52773.1 - 0.17 11.3 5.4 0.046 13.1 0.5 2.1 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Ig_6 PF18452.1 CDW52774.1 - 7.5e-05 22.2 1.9 0.0012 18.4 0.0 3.5 4 0 0 4 4 4 1 Immunoglobulin domain Ig_3 PF13927.6 CDW52774.1 - 0.00017 22.1 0.2 0.00062 20.3 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 CDW52774.1 - 0.00026 21.1 0.2 0.0011 19.0 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 CDW52774.1 - 0.0027 17.7 0.0 0.0063 16.6 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 CDW52774.1 - 0.0043 17.2 0.0 0.019 15.2 0.0 2.1 1 1 1 2 2 2 1 Immunoglobulin V-set domain Ig_2 PF13895.6 CDW52774.1 - 0.0061 16.9 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain Cyto_heme_lyase PF01265.17 CDW52775.1 - 6.4e-64 216.3 7.7 2.5e-63 214.4 7.7 1.7 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase 7TM_GPCR_Srsx PF10320.9 CDW52776.1 - 6.1e-13 48.7 16.5 8.2e-13 48.3 16.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 CDW52776.1 - 0.0004 20.0 3.1 0.0004 20.0 3.1 2.2 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_1 PF00001.21 CDW52776.1 - 0.067 12.5 13.4 0.089 12.1 12.6 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW52777.1 - 1.2e-14 54.3 20.3 1.6e-14 53.9 20.3 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 CDW52777.1 - 0.046 13.2 17.8 0.12 11.9 17.8 1.7 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc TMEM208_SND2 PF05620.11 CDW52778.1 - 3.8e-42 143.9 1.6 5.9e-42 143.3 1.6 1.2 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Tsg PF04668.12 CDW52778.1 - 1.5e-28 100.2 12.2 1.5e-28 100.2 12.2 3.4 2 2 0 2 2 2 1 Twisted gastrulation (Tsg) protein conserved region NUC153 PF08159.12 CDW52779.1 - 7.2e-13 48.1 0.4 1.3e-12 47.3 0.4 1.4 1 0 0 1 1 1 1 NUC153 domain F-box-like PF12937.7 CDW52780.1 - 4.5e-10 39.2 0.1 1.4e-09 37.7 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDW52780.1 - 1.1e-08 34.8 0.3 3.2e-08 33.3 0.3 1.8 1 0 0 1 1 1 1 F-box domain Calreticulin PF00262.18 CDW52781.1 - 2.5e-115 385.3 20.6 1.2e-56 192.1 2.1 4.2 2 2 2 4 4 4 4 Calreticulin family Fungal_TACC PF12709.7 CDW52781.1 - 0.024 15.1 5.8 0.4 11.2 0.0 3.2 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF1939 PF09154.10 CDW52781.1 - 0.19 11.9 2.4 24 5.2 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1939) Pkinase PF00069.25 CDW52782.1 - 9.7e-24 84.1 0.0 1.6e-23 83.4 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52782.1 - 1.6e-13 50.5 0.0 2.8e-13 49.8 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW52782.1 - 0.11 12.4 0.0 21 5.0 0.0 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family HSP20 PF00011.21 CDW52784.1 - 9.4e-06 25.7 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Homeodomain PF00046.29 CDW52785.1 - 2.3e-22 78.6 4.2 2.3e-22 78.6 4.2 1.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW52785.1 - 0.00068 19.5 0.2 0.0015 18.4 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Ion_trans PF00520.31 CDW52786.1 - 3e-199 658.7 87.2 4.2e-58 196.5 22.3 4.4 4 1 0 4 4 4 4 Ion transport protein GPHH PF16905.5 CDW52786.1 - 7.9e-31 105.6 0.2 1.6e-30 104.6 0.2 1.6 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.11 CDW52786.1 - 4.6e-25 87.6 0.2 4.6e-25 87.6 0.2 2.8 3 0 0 3 3 3 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.12 CDW52786.1 - 1.3e-12 47.1 63.3 1.1e-07 30.9 7.8 6.6 5 3 1 6 6 6 5 Polycystin cation channel Far-17a_AIG1 PF04750.14 CDW52787.1 - 1.6e-43 148.4 16.9 2.1e-43 148.0 16.9 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein SURF4 PF02077.15 CDW52788.1 - 2.1e-78 263.6 3.5 2.3e-54 184.8 0.2 2.0 1 1 1 2 2 2 2 SURF4 family SURF2 PF05477.11 CDW52788.1 - 1.6e-08 34.5 0.0 2.9e-08 33.7 0.0 1.3 1 1 0 1 1 1 1 Surfeit locus protein 2 (SURF2) DoxX PF07681.12 CDW52788.1 - 0.0043 17.6 0.6 0.0043 17.6 0.6 2.2 3 0 0 3 3 3 1 DoxX Glyco_transf_64 PF09258.10 CDW52789.1 - 3.6e-85 285.2 0.2 5.1e-85 284.7 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 CDW52789.1 - 8.8e-18 64.5 0.0 1.9e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Exostosin family Glycos_transf_2 PF00535.26 CDW52789.1 - 0.0004 20.3 0.0 0.00095 19.0 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 APG6_N PF17675.1 CDW52789.1 - 0.11 13.0 0.4 0.23 12.0 0.4 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region AAA_25 PF13481.6 CDW52790.1 - 2.1e-08 34.0 0.1 6.5e-08 32.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW52790.1 - 5.6e-06 26.7 0.1 1.5e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 CDW52790.1 - 2.6e-05 23.7 0.0 0.0082 15.5 0.0 2.2 1 1 1 2 2 2 2 DnaB-like helicase C terminal domain ATPase PF06745.13 CDW52790.1 - 0.0027 17.1 0.1 0.029 13.7 0.1 2.5 1 1 0 1 1 1 1 KaiC AAA_29 PF13555.6 CDW52790.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4435 PF14491.6 CDW52791.1 - 0.0049 16.8 0.2 0.0057 16.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4435) TMEM164 PF14808.6 CDW52792.1 - 1.3e-63 214.7 15.5 5.5e-61 206.1 15.5 2.0 1 1 0 1 1 1 1 TMEM164 family DUF2838 PF10998.8 CDW52792.1 - 0.021 15.1 5.4 0.021 15.1 5.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2838) Abhydrolase_3 PF07859.13 CDW52793.1 - 1.1e-55 188.8 0.0 1.1e-39 136.5 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold AAA_25 PF13481.6 CDW52793.1 - 1.9e-08 34.1 0.0 4.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain COesterase PF00135.28 CDW52793.1 - 1.1e-05 24.5 0.1 0.0014 17.6 0.0 2.4 2 0 0 2 2 2 2 Carboxylesterase family Say1_Mug180 PF10340.9 CDW52793.1 - 4.5e-05 22.5 0.1 7.7e-05 21.7 0.1 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase DnaB_C PF03796.15 CDW52793.1 - 0.0001 21.8 0.0 0.00032 20.1 0.0 1.8 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain ATPase PF06745.13 CDW52793.1 - 0.0031 16.9 0.3 0.016 14.6 0.3 1.9 1 1 0 1 1 1 1 KaiC Chlorophyllase2 PF12740.7 CDW52793.1 - 0.014 14.3 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Hydrolase_4 PF12146.8 CDW52793.1 - 0.033 13.4 0.0 0.062 12.6 0.0 1.5 1 1 0 1 1 1 0 Serine aminopeptidase, S33 ArfGap PF01412.18 CDW52794.1 - 4.3e-27 94.5 0.0 1.3e-26 93.0 0.0 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 CDW52794.1 - 1.4e-12 48.0 2.3 1.3e-06 28.9 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW52794.1 - 1.8e-08 34.8 0.4 4.6e-07 30.2 0.2 3.1 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW52794.1 - 4e-08 33.4 0.7 1e-07 32.0 0.3 2.0 2 0 0 2 2 1 1 Ankyrin repeats (many copies) PH PF00169.29 CDW52794.1 - 9.3e-08 32.5 1.1 1.8e-07 31.6 0.4 1.9 2 0 0 2 2 2 1 PH domain SH3_2 PF07653.17 CDW52794.1 - 1e-07 31.5 0.1 3.6e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain Ank PF00023.30 CDW52794.1 - 2.8e-06 27.5 0.0 0.75 10.4 0.0 4.6 4 2 0 4 4 4 2 Ankyrin repeat SH3_1 PF00018.28 CDW52794.1 - 5e-06 26.0 0.1 1.7e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CDW52794.1 - 3.5e-05 23.6 0.0 6.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.6 CDW52794.1 - 0.00032 20.9 0.0 0.21 12.2 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat BAR_3 PF16746.5 CDW52794.1 - 0.052 13.2 1.6 0.087 12.5 1.6 1.3 1 0 0 1 1 1 0 BAR domain of APPL family CDO_I PF05995.12 CDW52794.1 - 0.059 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Cysteine dioxygenase type I DUF1018 PF06252.12 CDW52794.1 - 0.087 13.8 0.0 0.27 12.2 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) zf-B_box PF00643.24 CDW52794.1 - 0.094 12.9 2.8 0.23 11.7 2.8 1.6 1 0 0 1 1 1 0 B-box zinc finger Choline_transpo PF04515.12 CDW52795.1 - 1.3e-37 129.7 39.3 1.3e-37 129.7 39.3 2.4 3 0 0 3 3 3 1 Plasma-membrane choline transporter TMEM239 PF15841.5 CDW52795.1 - 8 6.4 9.4 4 7.3 6.9 1.8 2 0 0 2 2 2 0 Transmembrane protein 239 family Ribosomal_S18 PF01084.20 CDW52796.1 - 2.8e-08 33.8 0.1 5.3e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Lar_restr_allev PF14354.6 CDW52796.1 - 0.79 10.1 4.6 0.6 10.5 1.4 2.1 2 0 0 2 2 2 0 Restriction alleviation protein Lar TFIIS_M PF07500.14 CDW52797.1 - 2.1e-34 118.4 1.0 2.1e-34 118.4 1.0 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 CDW52797.1 - 2.1e-17 62.7 8.8 3.5e-17 62.0 8.8 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 CDW52797.1 - 6.4e-14 51.7 1.9 7.5e-14 51.5 0.3 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Baculo_LEF5_C PF11792.8 CDW52797.1 - 0.087 12.5 0.2 0.087 12.5 0.2 1.8 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain WAC_Acf1_DNA_bd PF10537.9 CDW52797.1 - 0.92 10.1 2.9 3.9 8.0 0.2 2.4 1 1 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal Mito_carr PF00153.27 CDW52798.1 - 1.1e-59 198.3 0.5 1.4e-22 79.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Y_phosphatase PF00102.27 CDW52799.1 - 6.5e-65 219.0 0.0 8.2e-65 218.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 CDW52799.1 - 0.00068 19.5 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW52799.1 - 0.037 14.1 0.0 0.063 13.4 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate IF-2 PF11987.8 CDW52800.1 - 2.8e-26 91.7 0.4 1.4e-25 89.4 0.1 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU PF00009.27 CDW52800.1 - 1.2e-25 90.2 5.6 8.6e-23 80.9 5.6 3.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW52800.1 - 1.4e-07 31.5 0.1 3.2e-07 30.4 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CDW52800.1 - 0.00031 20.6 0.1 0.00098 19.0 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 SRPRB PF09439.10 CDW52800.1 - 0.0013 18.2 0.1 0.003 17.0 0.1 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.25 CDW52800.1 - 0.015 15.7 0.0 0.13 12.7 0.1 2.6 2 0 0 2 2 2 0 Elongation factor Tu domain 2 AAA_23 PF13476.6 CDW52800.1 - 0.082 13.4 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CDW52800.1 - 0.14 12.2 0.8 1.7 8.7 0.0 2.7 2 1 0 3 3 3 0 Dynamin family AAA_29 PF13555.6 CDW52800.1 - 0.15 11.8 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 CDW52800.1 - 0.19 11.9 0.4 0.46 10.7 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Myosin_tail_1 PF01576.19 CDW52801.1 - 0.00079 17.4 43.6 0.0013 16.6 43.6 1.3 1 0 0 1 1 1 1 Myosin tail SHE3 PF17078.5 CDW52801.1 - 0.0062 16.3 35.3 0.11 12.2 35.3 2.4 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 CENP-F_leu_zip PF10473.9 CDW52801.1 - 0.38 10.8 50.2 0.43 10.6 0.9 3.8 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 CDW52801.1 - 1.9 7.8 45.5 3.2 7.0 30.0 2.6 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 CDW52801.1 - 6.5 6.8 25.9 2 8.5 2.9 4.2 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 CDW52801.1 - 7.7 6.2 43.3 1.6 8.5 14.3 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Adenylsucc_synt PF00709.21 CDW52802.1 - 2.8e-81 273.6 0.0 5.2e-81 272.7 0.0 1.5 1 1 0 1 1 1 1 Adenylosuccinate synthetase DUF3247 PF11607.8 CDW52802.1 - 0.041 14.1 0.2 0.079 13.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) Y_phosphatase PF00102.27 CDW52803.1 - 8e-05 22.3 0.0 0.0002 21.0 0.0 1.7 1 1 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 CDW52803.1 - 0.0022 17.7 0.0 0.0073 16.0 0.0 1.8 1 1 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 CDW52803.1 - 0.004 17.0 1.6 0.061 13.1 0.8 2.3 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Sulfatase PF00884.23 CDW52804.1 - 6.1e-38 131.0 0.1 9.5e-38 130.3 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Herpes_UL21 PF03252.13 CDW52806.1 - 0.077 11.7 0.0 0.077 11.7 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus UL21 VASt PF16016.5 CDW52807.1 - 4.3e-33 114.9 0.4 1e-32 113.7 0.4 1.6 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 CDW52807.1 - 1.6e-22 79.5 0.3 4.2e-22 78.2 0.3 1.7 1 0 0 1 1 1 1 GRAM domain dCMP_cyt_deam_1 PF00383.23 CDW52808.1 - 1.8e-23 82.4 0.1 2.4e-23 81.9 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDW52808.1 - 5.4e-22 78.0 0.0 6.4e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 CDW52808.1 - 0.0012 19.0 0.0 0.0018 18.4 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 Lar_restr_allev PF14354.6 CDW52808.1 - 0.0052 17.1 0.7 0.013 15.8 0.7 1.8 1 0 0 1 1 1 1 Restriction alleviation protein Lar APOBEC2 PF18772.1 CDW52808.1 - 0.019 15.0 0.1 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 APOBEC2 NAD1 PF18778.1 CDW52808.1 - 0.033 14.3 0.1 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 Novel AID APOBEC clade 1 DNA_pol3_gamma3 PF12169.8 CDW52808.1 - 0.049 13.5 0.0 0.081 12.8 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III NAD2 PF18782.1 CDW52808.1 - 0.057 13.5 0.1 1 9.4 0.0 2.1 2 0 0 2 2 2 0 Novel AID APOBEC clade 2 Bd3614-deam PF14439.6 CDW52808.1 - 0.87 9.7 5.7 66 3.6 5.7 2.2 1 1 0 1 1 1 0 Bd3614-like deaminase CAP PF00188.26 CDW52809.1 - 1.2e-18 68.2 2.9 2.5e-18 67.1 2.9 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family ShK PF01549.24 CDW52809.1 - 0.00013 22.4 3.5 0.00013 22.4 3.5 4.2 5 0 0 5 5 5 2 ShK domain-like PMT_4TMC PF16192.5 CDW52809.1 - 4.6 6.8 6.9 4.2 6.9 0.3 2.5 2 1 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase Rhomboid PF01694.22 CDW52810.1 - 1.8e-21 76.7 5.7 3.1e-21 76.0 5.7 1.4 1 0 0 1 1 1 1 Rhomboid family COG6 PF06419.11 CDW52811.1 - 4e-113 378.8 17.4 7.4e-113 377.9 17.4 1.3 1 1 0 1 1 1 1 Conserved oligomeric complex COG6 CC2-LZ PF16516.5 CDW52811.1 - 4.7 7.6 8.5 0.73 10.2 1.9 2.8 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator 14-3-3 PF00244.20 CDW52812.1 - 4.3e-104 346.9 4.1 3.1e-66 223.1 0.3 2.0 2 0 0 2 2 2 2 14-3-3 protein FliM PF02154.15 CDW52812.1 - 0.049 13.5 0.1 0.082 12.8 0.1 1.3 1 0 0 1 1 1 0 Flagellar motor switch protein FliM DUF4518 PF15008.6 CDW52812.1 - 0.091 11.9 0.7 0.8 8.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) mRNA_cap_enzyme PF01331.19 CDW52813.1 - 1.8e-51 174.7 0.0 7.7e-51 172.7 0.0 1.9 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 CDW52813.1 - 1.4e-15 57.8 0.0 2.9e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain Peroxin-22 PF12827.7 CDW52813.1 - 0.17 11.8 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family PH PF00169.29 CDW52814.1 - 3.8e-12 46.7 0.0 1.3e-11 45.0 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CDW52814.1 - 5e-05 23.7 1.9 0.00014 22.2 0.1 2.7 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 CDW52814.1 - 0.00064 20.0 0.3 0.002 18.4 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain DUF1664 PF07889.12 CDW52814.1 - 0.0069 16.4 7.5 0.0069 16.4 7.5 3.0 1 1 2 3 3 3 1 Protein of unknown function (DUF1664) PH_4 PF15404.6 CDW52814.1 - 0.057 13.2 0.1 0.057 13.2 0.1 3.1 2 2 1 3 3 3 0 Pleckstrin homology domain DUF4107 PF13389.6 CDW52814.1 - 0.11 12.6 4.9 3.5 7.8 0.5 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4107) DUF948 PF06103.11 CDW52814.1 - 3.9 7.8 7.3 9.5 6.6 2.6 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Z1 PF10593.9 CDW52814.1 - 6.2 6.3 14.5 1.7 8.1 9.4 2.5 2 1 0 2 2 2 0 Z1 domain Suppressor_APC PF11414.8 CDW52814.1 - 7.4 6.7 27.0 0.42 10.7 3.0 3.4 4 0 0 4 4 4 0 Adenomatous polyposis coli tumour suppressor protein TMEM151 PF14857.6 CDW52815.1 - 4.5e-125 417.9 2.4 6.2e-125 417.5 2.4 1.1 1 0 0 1 1 1 1 TMEM151 family TMEM52 PF14979.6 CDW52815.1 - 0.12 12.3 0.4 3.8 7.4 0.1 2.8 3 0 0 3 3 3 0 Transmembrane 52 Sec23_trunk PF04811.15 CDW52816.1 - 6.2e-62 209.3 0.0 9.4e-62 208.7 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CDW52816.1 - 9.3e-21 73.6 0.2 1.9e-20 72.6 0.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CDW52816.1 - 2.7e-18 66.5 0.0 5.7e-18 65.4 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CDW52816.1 - 2.6e-12 46.5 4.9 8.4e-12 44.9 4.9 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CDW52816.1 - 1.7e-05 24.7 0.0 3.7e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Phosducin PF02114.16 CDW52817.1 - 3.7e-46 157.2 0.5 1e-35 123.0 0.0 2.1 1 1 1 2 2 2 2 Phosducin FliT PF05400.13 CDW52817.1 - 0.082 13.7 1.9 0.12 13.2 0.5 1.9 2 0 0 2 2 2 0 Flagellar protein FliT HisK_sensor PF18698.1 CDW52817.1 - 0.17 12.3 1.5 0.27 11.6 1.5 1.3 1 0 0 1 1 1 0 Histidine kinase sensor domain DHHC PF01529.20 CDW52818.1 - 2.3e-35 121.6 8.2 5.2e-35 120.5 8.2 1.6 1 0 0 1 1 1 1 DHHC palmitoyltransferase SH3_9 PF14604.6 CDW52818.1 - 0.00019 21.2 0.0 0.00047 20.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Phage_BR0599 PF09356.10 CDW52818.1 - 0.033 14.5 0.0 0.14 12.5 0.0 2.0 2 0 0 2 2 2 0 Phage conserved hypothetical protein BR0599 Zf_RING PF16744.5 CDW52818.1 - 3.8 7.7 12.0 3.2 7.9 6.5 3.0 3 0 0 3 3 3 0 KIAA1045 RING finger Casein_kappa PF00997.18 CDW52819.1 - 0.26 11.4 1.5 0.53 10.4 1.5 1.4 1 0 0 1 1 1 0 Kappa casein Reticulon PF02453.17 CDW52820.1 - 1.6e-29 102.9 10.8 2.1e-29 102.5 10.8 1.1 1 0 0 1 1 1 1 Reticulon PRT_C PF08372.10 CDW52820.1 - 6.3 6.5 5.8 3 7.6 2.1 2.1 2 1 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal SecE PF00584.20 CDW52821.1 - 3.4e-17 62.1 0.1 4.8e-17 61.6 0.1 1.2 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex HMG_box PF00505.19 CDW52822.1 - 2.6e-16 59.8 0.3 4.1e-16 59.2 0.3 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW52822.1 - 9.8e-11 42.1 0.6 1.8e-10 41.3 0.6 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 CDW52822.1 - 0.0055 17.3 0.2 0.012 16.2 0.1 1.6 1 1 0 1 1 1 1 YABBY protein LRR_8 PF13855.6 CDW52823.1 - 8.4e-23 79.9 21.1 1.1e-09 37.9 0.1 4.0 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 CDW52823.1 - 1.7e-10 41.0 14.7 0.0001 22.6 1.9 4.9 3 1 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW52823.1 - 1.1e-07 31.5 4.5 0.0022 17.5 0.3 2.3 1 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 CDW52823.1 - 0.00016 21.7 11.6 15 6.6 0.0 6.5 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_6 PF13516.6 CDW52823.1 - 0.0019 18.1 12.4 18 5.7 0.0 5.7 5 0 0 5 5 5 3 Leucine Rich repeat IDH PF03971.14 CDW52824.1 - 0.11 10.9 0.3 0.14 10.6 0.3 1.1 1 0 0 1 1 1 0 Monomeric isocitrate dehydrogenase Albumin_I_a PF16720.5 CDW52824.1 - 8.3 6.4 8.4 3.1 7.8 0.0 3.8 4 1 0 4 4 4 0 Albumin I chain a eIF3_subunit PF08597.10 CDW52825.1 - 0.12 12.3 0.2 44 3.9 0.0 3.2 2 1 2 4 4 4 0 Translation initiation factor eIF3 subunit UPF0203 PF05254.12 CDW52825.1 - 0.2 11.9 0.0 0.2 11.9 0.0 3.3 3 2 1 4 4 4 0 Uncharacterised protein family (UPF0203) Ras PF00071.22 CDW52826.1 - 4.8e-53 179.1 0.0 5.6e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52826.1 - 3.7e-21 75.6 0.0 5.1e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52826.1 - 2.1e-08 33.8 0.0 2.7e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family dCMP_cyt_deam_1 PF00383.23 CDW52827.1 - 1.9e-21 75.8 0.1 2.7e-21 75.4 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDW52827.1 - 4.8e-14 52.3 0.1 5.7e-14 52.0 0.1 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 CDW52827.1 - 0.00059 19.9 0.2 0.00098 19.2 0.2 1.6 1 1 0 1 1 1 1 Bd3614-like deaminase Motile_Sperm PF00635.26 CDW52828.1 - 6.7e-11 42.0 0.1 1.3e-10 41.1 0.1 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Sulfotransfer_2 PF03567.14 CDW52829.1 - 1.7e-51 175.6 0.9 2.1e-51 175.2 0.9 1.1 1 0 0 1 1 1 1 Sulfotransferase family RINT1_TIP1 PF04437.13 CDW52830.1 - 8e-30 104.2 15.5 1e-29 103.8 12.7 2.5 2 1 0 2 2 2 1 RINT-1 / TIP-1 family BP28CT PF08146.12 CDW52830.1 - 0.062 13.1 1.6 0.14 12.0 0.2 2.3 2 0 0 2 2 2 0 BP28CT (NUC211) domain Lipoprotein_7 PF01540.16 CDW52830.1 - 0.2 10.9 3.9 0.3 10.3 3.0 1.7 2 0 0 2 2 2 0 Adhesin lipoprotein Occludin_ELL PF07303.13 CDW52830.1 - 0.26 12.0 2.1 3.4 8.4 0.1 3.3 2 1 2 4 4 4 0 Occludin homology domain EF-hand_12 PF17901.1 CDW52830.1 - 0.52 10.8 4.5 0.37 11.3 0.3 2.9 3 0 0 3 3 3 0 EF-hand fold domain Baculo_PEP_C PF04513.12 CDW52830.1 - 0.6 10.1 6.5 1.1 9.3 0.6 3.4 2 2 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus KASH_CCD PF14662.6 CDW52830.1 - 3.5 7.4 9.2 0.062 13.1 1.6 1.9 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH COG5 PF10392.9 CDW52830.1 - 5 7.3 10.1 0.38 10.9 1.3 3.3 3 1 1 4 4 4 0 Golgi transport complex subunit 5 zf-C4 PF00105.18 CDW52832.1 - 1.3e-29 102.5 14.8 2.8e-29 101.3 14.8 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW52832.1 - 2e-12 47.1 0.2 5e-12 45.8 0.2 1.6 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor RRM_1 PF00076.22 CDW52834.1 - 1.2e-18 66.7 0.0 1.5e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW52834.1 - 0.00034 20.7 0.0 0.00065 19.8 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CDW52834.1 - 0.018 15.1 0.0 0.029 14.4 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 CDW52834.1 - 0.043 13.8 0.0 0.062 13.3 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 CDW52834.1 - 0.18 12.0 0.0 1.7 8.8 0.0 1.9 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Ldl_recept_a PF00057.18 CDW52835.1 - 1.4e-47 159.6 136.3 1.3e-07 31.7 12.8 10.6 9 1 1 10 10 10 9 Low-density lipoprotein receptor domain class A eIF3g PF12353.8 CDW52836.1 - 1.8e-20 73.6 0.4 3.4e-20 72.7 0.4 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 CDW52836.1 - 1.4e-17 63.3 0.0 2.6e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tctex-1 PF03645.13 CDW52836.1 - 4.4e-16 59.0 0.0 1.4e-15 57.4 0.0 1.8 1 0 0 1 1 1 1 Tctex-1 family zf-CCHC PF00098.23 CDW52836.1 - 0.0018 18.3 0.6 0.0034 17.4 0.6 1.5 1 0 0 1 1 1 1 Zinc knuckle PHM7_cyt PF14703.6 CDW52836.1 - 0.041 14.1 0.6 2.8 8.1 0.0 2.9 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DUF4412 PF14371.6 CDW52836.1 - 0.082 12.7 0.3 0.9 9.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4412) RRM_occluded PF16842.5 CDW52836.1 - 0.1 12.4 0.1 0.26 11.2 0.0 1.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif Globin PF00042.22 CDW52837.1 - 0.026 15.1 0.0 0.048 14.2 0.0 1.4 1 0 0 1 1 1 0 Globin RRM_3 PF08777.11 CDW52838.1 - 4.2e-18 65.3 0.1 7e-16 58.1 0.0 2.8 2 1 0 2 2 2 2 RNA binding motif La PF05383.17 CDW52838.1 - 1.5e-12 47.3 0.4 4.3e-12 45.9 0.4 1.8 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 CDW52838.1 - 2.5e-11 43.2 0.0 2.5e-06 27.2 0.1 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Hist_deacetyl PF00850.19 CDW52839.1 - 2.7e-80 270.1 0.1 3.3e-80 269.9 0.1 1.1 1 0 0 1 1 1 1 Histone deacetylase domain dCMP_cyt_deam_1 PF00383.23 CDW52840.1 - 2e-27 95.0 0.2 2.8e-27 94.5 0.2 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDW52840.1 - 1.5e-15 57.2 0.1 1.8e-15 56.9 0.1 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 CDW52840.1 - 0.0007 19.7 2.7 0.054 13.6 0.9 2.7 2 1 1 3 3 3 2 Bd3614-like deaminase Zf_RING PF16744.5 CDW52840.1 - 0.016 15.3 0.2 0.033 14.3 0.2 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger APOBEC3 PF18771.1 CDW52840.1 - 0.13 12.4 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 APOBEC3 Dynamin_M PF01031.20 CDW52841.1 - 5.4e-89 298.2 0.3 1.3e-88 297.0 0.0 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 CDW52841.1 - 1.5e-51 174.8 0.1 3.7e-51 173.5 0.1 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CDW52841.1 - 2.9e-30 104.3 2.1 8.8e-30 102.7 2.1 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CDW52841.1 - 3.6e-05 23.8 0.2 0.00011 22.2 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 CDW52841.1 - 0.086 13.1 0.0 0.92 9.7 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 CDW52841.1 - 0.27 10.5 1.6 4.5 6.5 0.0 2.7 2 0 0 2 2 2 0 AIG1 family CH PF00307.31 CDW52842.1 - 3.5e-28 97.9 0.6 7.2e-14 51.9 0.0 3.0 3 0 0 3 3 3 2 Calponin homology (CH) domain CH_2 PF06294.11 CDW52842.1 - 6.1e-05 23.1 0.2 0.25 11.5 0.0 2.3 2 0 0 2 2 2 2 CH-like domain in sperm protein CAMSAP_CH PF11971.8 CDW52842.1 - 0.00021 21.0 0.1 0.029 14.2 0.0 2.5 2 0 0 2 2 2 1 CAMSAP CH domain CENP-F_leu_zip PF10473.9 CDW52842.1 - 0.018 15.0 1.5 0.071 13.1 0.4 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1938 PF09153.10 CDW52842.1 - 0.1 12.7 0.0 0.42 10.7 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1938) ORF_12_N PF18042.1 CDW52842.1 - 0.12 12.8 0.1 1.5 9.3 0.0 2.3 1 1 1 2 2 2 0 ORF 12 gene product N-terminal FKBP_C PF00254.28 CDW52843.1 - 1.1e-29 102.5 0.0 1.4e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TRAP-gamma PF07074.12 CDW52844.1 - 1.1e-76 256.2 1.1 1.2e-76 256.0 1.1 1.0 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) RhoGAP PF00620.27 CDW52845.1 - 7.5e-22 77.8 0.1 2.4e-21 76.2 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 CDW52845.1 - 2.2e-09 37.4 3.8 2.2e-09 37.4 3.8 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain NAP PF00956.18 CDW52845.1 - 0.32 10.1 6.4 0.063 12.4 0.9 2.1 2 0 0 2 2 2 0 Nucleosome assembly protein (NAP) HIP1_clath_bdg PF16515.5 CDW52845.1 - 0.59 10.8 5.3 0.3 11.7 1.0 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF5522 PF17653.1 CDW52846.1 - 0.0026 17.7 0.5 0.0041 17.1 0.5 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5522) Oxidored-like PF09791.9 CDW52846.1 - 0.005 16.5 6.8 0.0083 15.8 6.8 1.3 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Oxidored-like PF09791.9 CDW52847.1 - 0.98 9.1 7.5 1.6 8.5 7.5 1.3 1 0 0 1 1 1 0 Oxidoreductase-like protein, N-terminal zf-RING_UBOX PF13445.6 CDW52848.1 - 2e-08 34.1 11.3 2.7e-08 33.7 3.1 3.4 3 1 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 CDW52848.1 - 2.8e-07 30.7 12.9 2.6e-06 27.6 9.1 3.1 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 CDW52848.1 - 3.3e-07 30.1 8.7 2.6e-06 27.2 6.1 2.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CDW52848.1 - 3e-06 27.0 11.0 1.9e-05 24.4 6.9 3.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW52848.1 - 4.6e-06 26.5 16.2 2.4e-05 24.2 7.5 3.5 4 0 0 4 4 4 2 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CDW52848.1 - 9.9e-05 22.1 10.4 9.9e-05 22.1 10.4 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDW52848.1 - 0.0012 18.9 13.3 0.0012 18.9 13.3 3.3 3 1 0 3 3 2 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 CDW52848.1 - 0.017 15.2 4.5 0.081 13.1 4.5 2.2 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 CDW52848.1 - 0.018 14.8 9.6 0.051 13.4 7.3 2.9 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 CDW52848.1 - 0.02 14.7 16.4 0.1 12.4 9.2 3.6 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Prominin PF05478.11 CDW52848.1 - 0.023 12.7 1.0 0.033 12.2 1.0 1.1 1 0 0 1 1 1 0 Prominin WD40_like PF17005.5 CDW52848.1 - 0.034 13.5 0.0 0.18 11.1 0.0 2.1 1 1 1 2 2 2 0 WD40-like domain zf-RING_11 PF17123.5 CDW52848.1 - 0.052 13.3 10.5 0.075 12.8 4.9 3.3 3 0 0 3 3 3 0 RING-like zinc finger IBR PF01485.21 CDW52848.1 - 0.14 12.4 12.1 0.044 14.0 4.5 3.5 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain KELK PF15796.5 CDW52848.1 - 0.59 10.6 6.0 1.3 9.6 6.0 1.4 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FYVE PF01363.21 CDW52848.1 - 3.8 7.7 18.7 0.8 9.9 12.4 3.0 2 1 1 3 3 3 0 FYVE zinc finger FYVE_2 PF02318.16 CDW52848.1 - 9.9 6.4 12.3 2.4 8.4 5.5 2.7 2 0 0 2 2 2 0 FYVE-type zinc finger MBT PF02820.18 CDW52850.1 - 5.8e-15 55.4 0.2 7.1e-08 32.7 0.0 4.2 4 0 0 4 4 4 2 mbt repeat SLED PF12140.8 CDW52850.1 - 5e-12 46.3 0.3 1.7e-11 44.6 0.1 2.1 2 0 0 2 2 2 1 SLED domain SapB_2 PF03489.17 CDW52850.1 - 3.8e-06 26.9 11.3 2.5e-05 24.3 0.1 3.9 4 0 0 4 4 4 2 Saposin-like type B, region 2 SapB_1 PF05184.15 CDW52850.1 - 5.5e-06 26.3 0.0 0.09 12.8 0.0 2.7 2 0 0 2 2 2 2 Saposin-like type B, region 1 EFF-AFF PF14884.6 CDW52852.1 - 2.1e-85 287.1 0.5 2.5e-85 286.8 0.5 1.0 1 0 0 1 1 1 1 Type I membrane glycoproteins cell-cell fusogen DUF720 PF05302.11 CDW52852.1 - 0.19 11.6 0.7 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF720) Ets PF00178.22 CDW52854.1 - 3.7e-35 120.2 1.1 5.6e-35 119.6 1.1 1.3 1 0 0 1 1 1 1 Ets-domain DC_STAMP PF07782.13 CDW52855.1 - 5.8e-39 133.9 0.1 1.1e-38 133.0 0.1 1.5 1 0 0 1 1 1 1 DC-STAMP-like protein PolC_DP2 PF03833.13 CDW52855.1 - 0.011 13.7 1.4 0.02 12.8 1.4 1.4 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 R3H-assoc PF13902.6 CDW52855.1 - 1.7 9.0 9.0 24 5.3 5.7 2.5 2 0 0 2 2 2 0 R3H-associated N-terminal domain Pkinase_Tyr PF07714.17 CDW52856.1 - 1.5e-91 306.3 0.0 2e-91 305.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW52856.1 - 6.9e-39 133.8 0.0 1.8e-36 125.9 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 CDW52856.1 - 0.0013 17.7 0.0 0.0019 17.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW52856.1 - 0.0016 17.8 0.0 0.0026 17.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-C2H2_2 PF12756.7 CDW52857.1 - 1.8e-28 98.8 13.5 2.8e-15 56.5 2.9 3.5 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 CDW52857.1 - 0.019 15.0 0.2 0.019 15.0 0.2 4.3 4 0 0 4 4 4 0 BED zinc finger MARVEL PF01284.23 CDW52857.1 - 0.11 12.5 1.1 0.21 11.6 1.1 1.4 1 0 0 1 1 1 0 Membrane-associating domain DUF2768 PF10966.8 CDW52857.1 - 0.18 12.3 3.9 0.41 11.1 3.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2768) zf-C2H2_4 PF13894.6 CDW52857.1 - 0.58 11.2 0.1 0.58 11.2 0.1 5.2 5 1 0 5 5 5 0 C2H2-type zinc finger FOXP-CC PF16159.5 CDW52857.1 - 0.78 10.4 3.5 87 3.9 0.1 4.0 3 1 1 4 4 4 0 FOXP coiled-coil domain PIG-L PF02585.17 CDW52858.1 - 1.7e-26 93.4 0.0 2.2e-26 93.0 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase DUF1358 PF07096.11 CDW52859.1 - 0.0037 17.2 0.2 0.0057 16.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) PID PF00640.23 CDW52860.1 - 1.8e-19 70.2 0.5 3e-19 69.5 0.4 1.3 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Motile_Sperm PF00635.26 CDW52862.1 - 4.4e-09 36.2 0.0 5.3e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Trypsin PF00089.26 CDW52863.1 - 8.4e-14 51.9 0.0 1.1e-13 51.6 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 CDW52863.1 - 0.008 16.6 0.0 0.011 16.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) FCH PF00611.23 CDW52864.1 - 5.9e-06 26.5 0.2 3e-05 24.2 0.2 2.4 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 CDW52864.1 - 6.4e-06 25.7 0.0 1.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CDW52864.1 - 0.0023 17.7 0.0 0.005 16.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 CDW52864.1 - 0.0031 17.3 7.1 0.0031 17.3 7.1 2.8 2 1 0 2 2 2 1 BAR domain of APPL family EzrA PF06160.12 CDW52864.1 - 0.087 11.0 11.6 0.04 12.1 8.8 1.8 3 0 0 3 3 3 0 Septation ring formation regulator, EzrA DinB_2 PF12867.7 CDW52864.1 - 0.16 12.5 0.0 2 8.9 0.0 2.4 2 0 0 2 2 2 0 DinB superfamily EF-G-binding_N PF07299.11 CDW52864.1 - 0.32 11.6 1.8 5.3 7.6 0.9 2.5 1 1 1 2 2 2 0 Elongation factor G-binding protein, N-terminal Radial_spoke_3 PF06098.11 CDW52864.1 - 0.35 10.1 15.5 1.2 8.4 8.4 2.6 1 1 0 2 2 2 0 Radial spoke protein 3 Fez1 PF06818.15 CDW52864.1 - 0.74 10.2 18.7 5.1 7.5 10.9 2.4 2 0 0 2 2 2 0 Fez1 Tup_N PF08581.10 CDW52864.1 - 1.4 9.2 8.8 5.7 7.3 1.3 3.3 3 0 0 3 3 3 0 Tup N-terminal T3SSipB PF16535.5 CDW52864.1 - 1.9 8.9 9.8 0.74 10.3 6.2 2.2 2 0 0 2 2 2 0 Type III cell invasion protein SipB Nup88 PF10168.9 CDW52864.1 - 2 6.2 11.1 3.2 5.5 11.1 1.3 1 0 0 1 1 1 0 Nuclear pore component MINDY_DUB PF04424.13 CDW52865.1 - 3.3e-35 120.6 0.1 6.3e-35 119.7 0.1 1.5 1 0 0 1 1 1 1 MINDY deubiquitinase Arena_ncap_C PF17290.2 CDW52865.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Arenavirus nucleocapsid C-terminal domain Chorion_2 PF03964.15 CDW52865.1 - 0.47 11.3 3.2 1.2 10.0 3.2 1.7 1 0 0 1 1 1 0 Chorion family 2 FYVE PF01363.21 CDW52866.1 - 3.2e-15 56.0 4.7 3.2e-15 56.0 4.7 2.1 2 0 0 2 2 2 1 FYVE zinc finger zf-C2H2_2 PF12756.7 CDW52866.1 - 0.0018 18.6 3.3 0.014 15.7 0.2 2.5 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) Rbsn PF11464.8 CDW52866.1 - 0.036 13.8 0.3 0.073 12.8 0.3 1.4 1 0 0 1 1 1 0 Rabenosyn Rab binding domain FYVE_2 PF02318.16 CDW52866.1 - 0.4 10.9 6.6 0.093 12.9 1.1 2.3 2 0 0 2 2 2 0 FYVE-type zinc finger Toxin_32 PF08120.11 CDW52867.1 - 0.15 11.9 7.4 0.32 10.8 7.4 1.5 1 0 0 1 1 1 0 Tamulustoxin family EGF_2 PF07974.13 CDW52868.1 - 1.5e-12 47.6 103.6 8.7e-06 26.0 15.0 6.5 5 1 1 6 6 6 4 EGF-like domain I-EGF_1 PF18372.1 CDW52868.1 - 6.2e-10 39.0 87.1 1.1e-05 25.4 9.8 7.0 6 2 0 6 6 6 4 Integrin beta epidermal growth factor like domain 1 DM PF00751.18 CDW52870.1 - 1.8e-31 107.8 40.3 1.5e-17 63.2 12.4 2.8 3 0 0 3 3 3 2 DM DNA binding domain DUF3772 PF12607.8 CDW52870.1 - 2.8 7.8 5.5 5.6 6.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3772) HOIP-UBA PF16678.5 CDW52872.1 - 0.0087 16.1 0.6 0.012 15.7 0.6 1.3 1 0 0 1 1 1 1 HOIP UBA domain pair ORC6 PF05460.13 CDW52872.1 - 0.015 14.6 2.1 0.015 14.6 2.1 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Pkinase_Tyr PF07714.17 CDW52873.1 - 1.3e-19 70.5 0.0 2.1e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW52873.1 - 2.6e-18 66.4 0.0 1e-17 64.4 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain OSR1_C PF12202.8 CDW52873.1 - 0.0036 17.5 0.5 0.015 15.5 0.1 2.1 2 0 0 2 2 2 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pyr_redox_2 PF07992.14 CDW52874.1 - 8.2e-40 136.9 0.0 1.8e-38 132.4 0.0 2.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDW52874.1 - 1.9e-22 79.6 0.0 3.6e-21 75.5 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDW52874.1 - 2.3e-14 53.7 1.7 1.2e-10 41.7 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW52874.1 - 5.5e-07 29.1 0.0 0.0018 17.6 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDW52874.1 - 5.6e-05 22.4 1.1 0.00013 21.2 1.1 1.6 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CDW52874.1 - 0.0015 18.0 2.8 0.0025 17.3 2.8 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CDW52874.1 - 0.0029 16.7 0.0 0.0038 16.4 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 CDW52874.1 - 0.0042 16.3 0.1 0.0083 15.4 0.1 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CDW52874.1 - 0.0056 15.4 0.9 0.0094 14.7 0.7 1.5 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CDW52874.1 - 0.0079 15.5 1.1 0.054 12.8 0.3 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 CDW52874.1 - 0.29 10.7 1.0 0.49 9.9 1.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDW52874.1 - 0.67 10.2 6.9 0.17 12.1 1.6 2.6 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain adh_short PF00106.25 CDW52875.1 - 5.4e-43 146.7 0.1 1e-42 145.8 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW52875.1 - 2.2e-32 112.5 0.1 4.1e-32 111.6 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW52875.1 - 1.6e-13 51.0 0.1 2.7e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDW52875.1 - 0.00066 19.2 0.3 0.0025 17.3 0.3 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Peptidase_C97 PF05903.14 CDW52876.1 - 4.3e-33 114.3 0.1 1.4e-32 112.6 0.0 1.9 2 0 0 2 2 2 1 PPPDE putative peptidase domain Clathrin_lg_ch PF01086.17 CDW52877.1 - 2.7e-39 135.6 23.2 4.7e-38 131.5 23.2 2.0 1 1 0 1 1 1 1 Clathrin light chain SprA-related PF12118.8 CDW52877.1 - 0.014 14.5 6.6 0.018 14.2 6.6 1.1 1 0 0 1 1 1 0 SprA-related family Glyco_transf_22 PF03901.17 CDW52878.1 - 4.2e-71 240.4 36.8 1.2e-40 140.0 15.9 2.2 1 1 1 2 2 2 2 Alg9-like mannosyltransferase family RRM_1 PF00076.22 CDW52879.1 - 1.8e-17 62.9 0.0 3.4e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDW52879.1 - 0.033 14.2 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 CDW52879.1 - 0.11 12.2 2.7 0.56 9.9 2.7 2.0 1 1 0 1 1 1 0 Ribonuclease B OB domain RRM_5 PF13893.6 CDW52879.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Complex1_LYR PF05347.15 CDW52880.1 - 5.1e-16 58.5 3.4 6.3e-16 58.2 3.4 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CDW52880.1 - 0.00037 21.2 1.5 0.00044 20.9 1.5 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 CDW52880.1 - 0.023 15.3 0.5 0.033 14.8 0.5 1.3 1 1 0 1 1 1 0 Complex1_LYR-like MAT1 PF06391.13 CDW52881.1 - 6.2e-40 137.2 6.7 1.8e-39 135.7 6.7 1.8 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 Pkinase PF00069.25 CDW52881.1 - 3.5e-09 36.4 0.0 9.4e-09 35.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain HEAT PF02985.22 CDW52881.1 - 5.6e-09 35.5 0.1 1.2 9.6 0.0 5.9 5 0 0 5 5 5 2 HEAT repeat zf-C3HC4_5 PF17121.5 CDW52881.1 - 2.2e-07 30.6 7.6 7e-07 29.0 7.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HEAT_2 PF13646.6 CDW52881.1 - 3.5e-07 30.5 0.1 0.014 15.8 0.0 3.7 2 1 3 5 5 4 2 HEAT repeats HEAT_EZ PF13513.6 CDW52881.1 - 8.9e-05 22.9 0.1 0.45 11.1 0.1 3.5 3 0 0 3 3 2 2 HEAT-like repeat Adaptin_N PF01602.20 CDW52881.1 - 0.00062 18.5 0.0 0.0022 16.7 0.0 1.8 1 1 0 1 1 1 1 Adaptin N terminal region Pkinase_Tyr PF07714.17 CDW52881.1 - 0.0012 18.2 0.0 0.0025 17.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Cnd1 PF12717.7 CDW52881.1 - 0.0017 18.4 2.4 0.15 12.1 0.0 3.5 3 1 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 zf-C3HC4 PF00097.25 CDW52881.1 - 0.0023 17.7 6.3 0.0061 16.4 6.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW52881.1 - 0.0027 18.0 6.0 0.006 16.9 6.0 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CDW52881.1 - 0.0054 16.7 6.2 0.013 15.4 6.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-UDP PF14569.6 CDW52881.1 - 0.0061 16.7 3.5 0.015 15.4 3.5 1.6 1 0 0 1 1 1 1 Zinc-binding RING-finger Prok-RING_4 PF14447.6 CDW52881.1 - 0.019 14.9 4.9 0.044 13.6 4.9 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CDW52881.1 - 0.022 14.8 6.3 0.06 13.4 6.3 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Arm PF00514.23 CDW52881.1 - 0.041 13.9 0.4 0.6 10.2 0.0 3.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat zf-RING_4 PF14570.6 CDW52881.1 - 0.054 13.3 8.2 0.21 11.4 8.2 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain CLASP_N PF12348.8 CDW52881.1 - 0.074 12.6 0.0 2.3 7.7 0.0 2.3 1 1 1 2 2 2 0 CLASP N terminal zf-C3HC4_2 PF13923.6 CDW52881.1 - 0.085 12.7 7.4 0.23 11.3 7.4 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MeMO_Hyd_G PF02964.16 CDW52881.1 - 0.098 12.7 1.5 0.22 11.5 1.5 1.5 1 0 0 1 1 1 0 Methane monooxygenase, hydrolase gamma chain zf-P11 PF03854.14 CDW52881.1 - 0.34 10.6 1.6 0.85 9.3 1.6 1.6 1 0 0 1 1 1 0 P-11 zinc finger zf-C3HC4_4 PF15227.6 CDW52881.1 - 0.75 10.0 6.4 2 8.6 6.4 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING TRAPP PF04051.16 CDW52882.1 - 5.4e-33 113.8 0.0 6.2e-33 113.6 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component ShK PF01549.24 CDW52884.1 - 2.4e-10 40.8 24.3 2e-05 25.0 7.7 2.5 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 CDW52884.1 - 0.00063 19.6 1.0 1.2 9.2 0.0 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Anoctamin PF04547.12 CDW52884.1 - 0.044 12.6 0.1 0.044 12.6 0.1 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel MIR PF02815.19 CDW52885.1 - 9.9e-13 48.3 0.0 4.2e-10 39.8 0.0 2.5 1 1 2 3 3 3 3 MIR domain Cript PF10235.9 CDW52886.1 - 1.4e-28 99.3 3.5 1.4e-28 99.3 3.5 1.5 1 1 0 1 1 1 1 Microtubule-associated protein CRIPT DUF2039 PF10217.9 CDW52886.1 - 0.00037 20.8 5.1 0.00037 20.8 5.1 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2039) Gin PF10764.9 CDW52886.1 - 0.012 15.6 7.3 0.36 10.8 0.0 3.2 2 1 0 2 2 2 0 Inhibitor of sigma-G Gin Rhodanese_C PF12368.8 CDW52886.1 - 0.016 15.6 6.8 0.033 14.6 2.3 2.1 2 0 0 2 2 2 0 Rhodanase C-terminal DZR PF12773.7 CDW52886.1 - 0.045 13.8 8.2 3.8 7.6 8.1 2.6 1 1 0 1 1 1 0 Double zinc ribbon zf-UDP PF14569.6 CDW52886.1 - 0.92 9.7 7.0 2.7 8.2 1.5 2.9 1 1 2 3 3 3 0 Zinc-binding RING-finger NOB1_Zn_bind PF08772.11 CDW52886.1 - 0.97 9.6 12.4 0.7 10.1 3.7 3.1 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like DUF1272 PF06906.11 CDW52886.1 - 0.99 9.5 7.3 1.7 8.8 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) DUF4428 PF14471.6 CDW52886.1 - 1 9.4 0.1 1 9.4 0.1 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4428) zf-RING_9 PF13901.6 CDW52886.1 - 2.4 8.1 12.1 1.9 8.4 2.2 2.5 1 1 1 2 2 2 0 Putative zinc-RING and/or ribbon NinF PF05810.12 CDW52886.1 - 4.9 7.1 7.9 42 4.1 2.8 3.0 2 1 1 3 3 3 0 NinF protein Metallophos PF00149.28 CDW52887.1 - 2.4e-36 126.2 0.0 4.8e-36 125.2 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 CDW52887.1 - 7.5e-20 71.0 0.4 8.4e-18 64.5 0.0 2.6 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 CDW52887.1 - 1.5e-18 65.7 8.4 3e-08 33.1 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDW52887.1 - 3.3e-17 61.1 5.6 2.1e-05 24.3 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52887.1 - 3.9e-13 48.5 7.5 0.00064 19.7 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDW52887.1 - 1.1e-12 47.4 3.4 7.1e-07 28.8 0.3 3.7 3 1 1 4 4 4 3 TPR repeat TPR_14 PF13428.6 CDW52887.1 - 4e-09 36.5 0.2 0.0039 17.9 0.0 3.0 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW52887.1 - 1.4e-08 35.2 1.8 0.00014 22.4 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW52887.1 - 2.7e-08 33.8 1.5 0.00025 21.1 0.4 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW52887.1 - 3.8e-07 30.5 3.4 0.0044 17.5 0.5 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDW52887.1 - 5.9e-07 29.4 3.5 0.026 14.9 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW52887.1 - 4.6e-06 26.9 1.7 0.054 14.1 0.3 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDW52887.1 - 4.4e-05 23.2 0.6 0.013 15.5 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDW52887.1 - 0.0002 21.6 6.1 0.065 13.5 2.2 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat SNAD4 PF18750.1 CDW52887.1 - 0.034 14.3 0.0 0.069 13.3 0.0 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 MIT PF04212.18 CDW52887.1 - 0.036 14.1 1.1 0.22 11.6 0.6 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain APOBEC2 PF18772.1 CDW52887.1 - 0.11 12.5 0.1 0.21 11.6 0.1 1.4 1 0 0 1 1 1 0 APOBEC2 TPR_20 PF14561.6 CDW52887.1 - 0.12 12.7 0.2 7.6 6.9 0.2 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDW52887.1 - 0.24 11.3 0.4 25 4.9 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 CDW52887.1 - 0.36 10.9 3.7 0.17 11.9 0.7 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat EGF_CA PF07645.15 CDW52888.1 - 4.4e-11 42.8 5.5 4.4e-11 42.8 5.5 2.5 3 0 0 3 3 3 1 Calcium-binding EGF domain cEGF PF12662.7 CDW52888.1 - 2.2e-05 24.3 8.3 0.0021 17.9 0.4 2.9 2 0 0 2 2 2 2 Complement Clr-like EGF-like hEGF PF12661.7 CDW52888.1 - 8.4e-05 23.1 0.9 0.00047 20.7 0.9 2.4 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 CDW52888.1 - 0.00065 19.7 2.9 0.00065 19.7 2.9 2.0 2 0 0 2 2 2 1 MSP1 EGF domain 1 EGF_3 PF12947.7 CDW52888.1 - 0.027 14.7 6.5 0.027 14.7 6.5 2.6 2 1 0 2 2 2 0 EGF domain EGF PF00008.27 CDW52888.1 - 0.03 14.6 0.5 0.03 14.6 0.5 3.1 3 0 0 3 3 3 0 EGF-like domain FXa_inhibition PF14670.6 CDW52888.1 - 4.5 7.6 15.9 2.8 8.3 5.0 2.6 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Glyco_hydro_2_C PF02836.17 CDW52889.1 - 4.8e-54 183.5 0.0 1.6e-26 93.2 0.0 2.5 2 1 1 3 3 3 2 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 CDW52889.1 - 1.9e-21 76.7 0.5 3.2e-21 76.0 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 CDW52889.1 - 1.6e-05 25.5 0.0 2.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 CDW52889.1 - 0.025 15.1 0.6 0.05 14.2 0.6 1.4 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain GTA_TIM PF13547.6 CDW52889.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 GTA TIM-barrel-like domain TTR-52 PF01060.23 CDW52890.1 - 1.6e-26 92.8 0.1 2.1e-26 92.4 0.1 1.1 1 0 0 1 1 1 1 Transthyretin-like family WAP PF00095.21 CDW52891.1 - 2.6e-27 94.9 68.8 2.7e-09 37.3 4.2 5.1 5 0 0 5 5 5 4 WAP-type (Whey Acidic Protein) 'four-disulfide core' Toxin_29 PF08116.11 CDW52891.1 - 0.052 13.6 2.2 0.052 13.6 2.2 6.1 6 1 0 6 6 6 0 PhTx neurotoxin family Calponin PF00402.18 CDW52892.1 - 5.6e-66 217.7 34.1 1.5e-11 43.7 0.4 7.5 7 0 0 7 7 7 7 Calponin family repeat TPR_2 PF07719.17 CDW52893.1 - 1.1e-20 71.9 6.6 0.0057 16.7 0.0 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDW52893.1 - 8.7e-18 63.3 10.5 0.00057 19.6 0.0 6.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDW52893.1 - 1.9e-15 56.9 3.1 0.00023 21.4 0.1 5.2 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDW52893.1 - 7.3e-13 47.6 7.4 0.025 14.8 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDW52893.1 - 1.3e-11 44.9 2.3 0.016 15.7 0.0 5.3 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 CDW52893.1 - 7.8e-09 35.6 0.1 5.2 8.2 0.0 6.4 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDW52893.1 - 4.1e-07 29.9 5.0 0.055 13.9 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW52893.1 - 9.9e-07 29.0 9.0 0.47 11.2 0.0 7.2 7 1 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDW52893.1 - 1.4e-06 28.8 0.0 0.09 13.4 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW52893.1 - 2.1e-05 24.6 14.5 0.024 14.8 0.1 5.0 2 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_WDAD PF04053.14 CDW52893.1 - 3.2e-05 23.2 0.4 5.4e-05 22.4 0.4 1.3 1 0 0 1 1 1 1 Coatomer WD associated region TPR_7 PF13176.6 CDW52893.1 - 6.3e-05 22.7 0.2 4.4 7.6 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDW52893.1 - 9.5e-05 22.5 0.0 15 5.8 0.0 4.7 2 1 3 5 5 5 0 Tetratricopeptide repeat Coatomer_E PF04733.14 CDW52893.1 - 0.00012 21.6 1.7 0.00046 19.7 1.5 2.1 1 1 1 2 2 2 2 Coatomer epsilon subunit TPR_15 PF13429.6 CDW52893.1 - 0.0039 16.4 2.2 0.06 12.6 0.5 2.8 1 1 1 3 3 3 1 Tetratricopeptide repeat ChAPs PF09295.10 CDW52893.1 - 0.043 12.8 0.5 0.25 10.3 0.1 2.0 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) SPOB_a PF14689.6 CDW52893.1 - 0.11 12.3 0.2 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain Glyco_transf_10 PF00852.19 CDW52894.1 - 3.2e-45 154.0 0.4 5.1e-45 153.4 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW52894.1 - 2.7e-09 37.5 0.0 5.6e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal CN_hydrolase PF00795.22 CDW52895.1 - 3.6e-23 82.2 0.0 7.3e-22 77.9 0.0 1.9 1 1 1 2 2 2 2 Carbon-nitrogen hydrolase RYDR_ITPR PF01365.21 CDW52896.1 - 2.7e-115 382.8 12.1 2.1e-68 229.7 0.2 3.3 3 0 0 3 3 3 2 RIH domain RyR PF02026.16 CDW52896.1 - 3.2e-104 341.3 1.8 7.3e-30 103.0 0.0 4.8 4 0 0 4 4 4 4 RyR domain SPRY PF00622.28 CDW52896.1 - 1.4e-52 176.9 1.0 2.3e-19 69.7 0.0 3.6 3 0 0 3 3 3 3 SPRY domain Ins145_P3_rec PF08709.11 CDW52896.1 - 2.9e-48 163.9 0.1 7.5e-47 159.3 0.0 2.8 3 0 0 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 CDW52896.1 - 4.6e-44 150.5 0.3 3.9e-39 134.4 0.0 2.7 2 0 0 2 2 2 2 MIR domain RIH_assoc PF08454.11 CDW52896.1 - 6.3e-31 106.2 0.4 6.3e-31 106.2 0.4 3.9 5 0 0 5 5 5 1 RyR and IP3R Homology associated RR_TM4-6 PF06459.12 CDW52896.1 - 6.4e-30 104.9 0.2 6.4e-30 104.9 0.2 2.5 2 0 0 2 2 1 1 Ryanodine Receptor TM 4-6 Ion_trans PF00520.31 CDW52896.1 - 1.6e-12 47.2 8.1 3.7e-12 46.0 8.1 1.6 1 0 0 1 1 1 1 Ion transport protein EF-hand_7 PF13499.6 CDW52896.1 - 3.7e-10 40.1 0.3 3.1e-09 37.2 0.3 2.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 CDW52896.1 - 1.2e-08 34.0 0.1 0.00042 19.7 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 CDW52896.1 - 1.4e-08 33.7 0.5 0.003 17.0 0.0 3.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDW52896.1 - 3.6e-07 29.9 0.4 1.7e-06 27.7 0.4 2.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 CDW52896.1 - 7.8e-07 28.5 0.7 0.00064 19.4 0.0 3.7 3 0 0 3 3 3 1 EF-hand domain Pacs-1 PF10254.9 CDW52897.1 - 6.4e-87 292.2 0.5 1.3e-86 291.1 0.1 1.8 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein Zwint PF15556.6 CDW52897.1 - 0.045 13.2 0.2 0.97 8.9 0.1 2.2 2 0 0 2 2 2 0 ZW10 interactor Lyase_1 PF00206.20 CDW52898.1 - 2.8e-118 394.9 0.0 3.8e-118 394.4 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CDW52898.1 - 2.2e-27 95.2 0.2 8.8e-27 93.3 0.0 2.2 2 0 0 2 2 2 1 Fumarase C C-terminus FPRL1_inhibitor PF16104.5 CDW52898.1 - 0.15 12.2 0.1 0.34 11.0 0.1 1.5 1 0 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein INTS5_C PF14838.6 CDW52899.1 - 2e-64 218.5 15.1 2.8e-64 218.0 15.1 1.2 1 0 0 1 1 1 1 Integrator complex subunit 5 C-terminus INTS5_N PF14837.6 CDW52899.1 - 2.7e-33 115.4 1.2 5.7e-33 114.3 0.4 2.0 2 0 0 2 2 2 1 Integrator complex subunit 5 N-terminus DUF632 PF04782.12 CDW52899.1 - 0.0065 15.8 0.1 0.022 14.1 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF632) DehI PF10778.9 CDW52899.1 - 0.15 12.2 0.0 29 4.8 0.0 2.9 3 0 0 3 3 3 0 Halocarboxylic acid dehydrogenase DehI Ras PF00071.22 CDW52900.1 - 9.3e-48 161.9 0.1 2.2e-47 160.6 0.1 1.7 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW52900.1 - 4.9e-34 117.1 0.1 1.2e-33 115.8 0.1 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW52900.1 - 4.6e-16 58.8 0.0 1.2e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family EF-hand_7 PF13499.6 CDW52900.1 - 3.2e-09 37.1 2.0 3.2e-09 37.1 2.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDW52900.1 - 2.5e-08 33.2 1.3 0.00058 19.6 0.3 3.0 2 0 0 2 2 2 2 EF-hand domain Gtr1_RagA PF04670.12 CDW52900.1 - 7.1e-08 32.1 0.0 7.1e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW52900.1 - 1.1e-07 32.0 0.4 3e-07 30.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 CDW52900.1 - 2.8e-07 29.6 2.3 0.00035 19.9 0.5 3.1 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDW52900.1 - 6.4e-06 25.9 2.1 1.4e-05 24.9 0.9 2.2 1 1 1 2 2 2 1 EF-hand domain pair SRPRB PF09439.10 CDW52900.1 - 1.4e-05 24.6 1.4 4.5e-05 22.9 0.0 2.4 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CDW52900.1 - 0.00063 19.7 3.0 0.2 11.6 0.0 3.1 3 1 0 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 CDW52900.1 - 0.0038 16.8 5.5 0.0065 16.0 0.0 3.2 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain EF-hand_5 PF13202.6 CDW52900.1 - 0.0063 16.0 1.6 0.016 14.7 0.2 2.4 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 CDW52900.1 - 0.009 16.0 1.0 0.039 13.9 0.1 2.5 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand AAA_24 PF13479.6 CDW52900.1 - 0.011 15.4 1.3 0.13 11.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain DUF3872 PF12988.7 CDW52900.1 - 0.016 15.0 0.0 0.043 13.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3872) Spc7 PF08317.11 CDW52900.1 - 0.047 12.6 20.7 0.098 11.5 20.7 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_22 PF13401.6 CDW52900.1 - 0.33 11.2 2.4 1.4 9.2 0.0 3.2 2 2 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDW52900.1 - 0.39 11.1 0.0 0.39 11.1 0.0 3.0 3 1 0 3 3 2 0 AAA ATPase domain Cep57_MT_bd PF06657.13 CDW52900.1 - 0.6 10.6 15.4 0.53 10.8 3.9 3.4 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF3854 PF12965.7 CDW52900.1 - 1.1 9.3 5.3 14 5.6 1.7 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3854) Dynamin_N PF00350.23 CDW52900.1 - 1.8 8.6 8.1 8.7 6.4 0.0 3.9 3 1 0 3 3 2 0 Dynamin family ERp29 PF07749.12 CDW52900.1 - 6.3 7.8 12.7 1.9 9.4 7.3 2.9 2 1 1 3 3 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain LSM PF01423.22 CDW52902.1 - 4.3e-17 61.6 0.1 6.2e-17 61.1 0.1 1.2 1 0 0 1 1 1 1 LSM domain RNA_pol_Rpb2_45 PF10385.9 CDW52902.1 - 0.15 12.3 0.1 0.22 11.8 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase beta subunit external 1 domain Ly-6_related PF06579.12 CDW52903.1 - 1.3e-11 44.8 0.1 1.6e-11 44.5 0.1 1.1 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein Piwi PF02171.17 CDW52904.1 - 1.9e-76 257.2 0.0 2.7e-76 256.7 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 CDW52904.1 - 6.5e-14 51.9 1.5 8.1e-14 51.6 0.1 1.9 2 0 0 2 2 2 1 PAZ domain ArgoMid PF16487.5 CDW52904.1 - 1.4e-10 41.2 0.2 3.9e-10 39.9 0.2 1.7 1 0 0 1 1 1 1 Mid domain of argonaute ArgoN PF16486.5 CDW52904.1 - 8.3e-08 32.9 0.0 3.6e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL2 PF16488.5 CDW52904.1 - 9.6e-08 32.3 0.2 6.4e-07 29.6 0.0 2.6 3 0 0 3 3 3 1 Argonaute linker 2 domain IATP PF04568.12 CDW52905.1 - 4.1e-24 84.9 1.1 4.1e-24 84.9 1.1 1.5 2 0 0 2 2 2 1 Mitochondrial ATPase inhibitor, IATP Fib_alpha PF08702.10 CDW52905.1 - 0.079 13.1 3.0 0.11 12.7 3.0 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family YebO PF13974.6 CDW52905.1 - 0.16 12.1 3.6 0.26 11.4 3.6 1.3 1 0 0 1 1 1 0 YebO-like protein DEAD PF00270.29 CDW52906.1 - 6.1e-39 133.6 0.3 4.4e-38 130.8 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW52906.1 - 1.4e-28 99.4 0.1 5.1e-27 94.4 0.1 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Glyoxalase_5 PF14696.6 CDW52906.1 - 0.028 14.6 0.0 0.07 13.3 0.0 1.7 1 0 0 1 1 1 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Radical_SAM_C PF16199.5 CDW52907.1 - 5.6e-32 109.6 0.0 1.1e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CDW52907.1 - 6.2e-21 75.5 0.5 3.6e-20 73.0 0.1 2.4 4 0 0 4 4 4 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 CDW52907.1 - 8.2e-07 29.3 0.0 1.6e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW52907.1 - 0.00044 20.2 0.0 0.00094 19.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain EnY2 PF10163.9 CDW52908.1 - 1.1e-16 61.0 0.8 1.2e-16 60.9 0.8 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 Sin3a_C PF16879.5 CDW52908.1 - 0.0011 18.7 0.1 0.0012 18.7 0.1 1.0 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein ULD PF16534.5 CDW52909.1 - 5.5e-23 81.1 0.0 1.2e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like oligomerisation domain of SATB Homeodomain PF00046.29 CDW52909.1 - 2.9e-11 43.0 10.0 3e-08 33.4 0.5 2.9 2 1 0 2 2 2 2 Homeodomain Homeobox_KN PF05920.11 CDW52909.1 - 0.0004 20.2 3.4 0.002 18.0 0.3 2.9 2 0 0 2 2 2 1 Homeobox KN domain Amino_oxidase PF01593.24 CDW52911.1 - 8.2e-65 219.8 0.0 1.2e-64 219.3 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 CDW52911.1 - 4.2e-11 43.0 0.1 1.5e-10 41.3 0.0 2.0 2 0 0 2 2 2 1 SWIRM domain NAD_binding_8 PF13450.6 CDW52911.1 - 4.3e-10 39.7 0.6 1.2e-09 38.2 0.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain zf-CW PF07496.15 CDW52911.1 - 6.7e-07 29.2 2.5 2.1e-06 27.6 2.5 1.9 1 0 0 1 1 1 1 CW-type Zinc Finger Pyr_redox PF00070.27 CDW52911.1 - 2.6e-06 27.9 1.4 0.00026 21.5 0.5 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDW52911.1 - 3.5e-06 26.4 0.2 0.00054 19.3 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDW52911.1 - 4.2e-06 26.6 0.0 8.5e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CDW52911.1 - 2.9e-05 23.0 0.3 0.00085 18.1 0.3 2.3 2 0 0 2 2 2 1 HI0933-like protein AlaDh_PNT_C PF01262.21 CDW52911.1 - 7.5e-05 22.1 0.2 0.00013 21.3 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CDW52911.1 - 0.00024 20.3 0.3 0.00041 19.6 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 CDW52911.1 - 0.00025 20.4 0.4 0.00041 19.7 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CDW52911.1 - 0.00028 20.2 0.3 0.00052 19.3 0.3 1.4 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 CDW52911.1 - 0.00082 18.8 2.8 0.0013 18.2 2.8 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CDW52911.1 - 0.0029 16.9 1.1 0.018 14.3 0.7 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDW52911.1 - 0.0095 15.9 0.4 0.66 9.9 0.3 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding GIDA PF01134.22 CDW52911.1 - 0.015 14.4 2.0 0.024 13.7 2.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A CoA_transf_3 PF02515.17 CDW52911.1 - 0.22 10.6 0.6 1.5 7.9 0.1 2.2 2 1 0 2 2 2 0 CoA-transferase family III Lycopene_cycl PF05834.12 CDW52911.1 - 0.31 10.0 0.6 1.5 7.8 0.4 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein DREV PF05219.12 CDW52912.1 - 7.1e-78 261.3 0.1 8e-78 261.2 0.1 1.0 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.6 CDW52912.1 - 8.7e-06 25.7 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW52912.1 - 0.019 15.7 0.0 0.046 14.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CDW52912.1 - 0.036 14.8 0.0 0.066 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain tRNA_U5-meth_tr PF05958.11 CDW52912.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase EB PF01683.18 CDW52913.1 - 0.00015 22.0 31.8 0.037 14.3 9.4 3.9 2 2 2 4 4 4 4 EB module Dickkopf_N PF04706.12 CDW52913.1 - 0.025 15.0 36.0 0.6 10.6 13.7 3.4 2 2 2 4 4 4 0 Dickkopf N-terminal cysteine-rich region Dickkopf_N PF04706.12 CDW52914.1 - 4.4e-06 27.1 71.6 0.0094 16.4 11.0 6.3 6 0 0 6 6 6 5 Dickkopf N-terminal cysteine-rich region EB PF01683.18 CDW52914.1 - 2.5e-05 24.5 78.1 0.013 15.7 8.3 7.3 4 3 3 8 8 8 8 EB module Trypan_PARP PF05887.11 CDW52914.1 - 0.17 11.8 29.7 0.29 11.1 29.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CarbpepA_inh PF02977.15 CDW52914.1 - 0.19 11.6 64.0 0.19 11.6 1.5 7.2 4 3 3 7 7 7 0 Carboxypeptidase A inhibitor DUF3391 PF11871.8 CDW52914.1 - 2.8 8.5 7.5 4.1 7.9 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Alanine_zipper PF11839.8 CDW52914.1 - 8.1 6.9 12.4 16 5.9 12.4 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein SYS1 PF09801.9 CDW52915.1 - 7.2e-39 133.2 8.7 8.7e-39 132.9 8.7 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network A_deaminase PF00962.22 CDW52917.1 - 8.8e-110 367.1 0.1 1.3e-109 366.5 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Gtr1_RagA PF04670.12 CDW52918.1 - 1.3e-67 227.6 1.9 2.2e-67 226.8 1.9 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 CDW52918.1 - 2.5e-05 23.8 0.1 7.7e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 CDW52918.1 - 0.00096 19.4 0.0 0.0017 18.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CDW52918.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDW52918.1 - 0.014 15.4 0.0 0.044 13.9 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ras PF00071.22 CDW52918.1 - 0.025 14.2 0.2 0.044 13.4 0.2 1.4 1 0 0 1 1 1 0 Ras family AAA_16 PF13191.6 CDW52918.1 - 0.14 12.5 0.2 0.67 10.3 0.0 2.1 3 0 0 3 3 3 0 AAA ATPase domain Angiomotin_C PF12240.8 CDW52919.1 - 1.2e-51 175.2 19.7 1.2e-51 175.2 19.7 4.1 3 1 1 4 4 4 1 Angiomotin C terminal EB PF01683.18 CDW52920.1 - 3.1e-179 581.3 452.2 9.9e-12 45.0 9.3 34.0 15 8 19 34 34 34 33 EB module Dickkopf_N PF04706.12 CDW52920.1 - 0.01 16.3 0.9 0.01 16.3 0.9 32.1 29 4 1 30 30 30 0 Dickkopf N-terminal cysteine-rich region Polysacc_deac_1 PF01522.21 CDW52920.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide deacetylase MH2 PF03166.14 CDW52922.1 - 2.3e-11 44.3 0.0 2.7e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 MH2 domain Pkinase PF00069.25 CDW52923.1 - 1.5e-07 31.1 0.0 3.6e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52923.1 - 8.3e-06 25.3 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 CDW52923.1 - 0.27 11.6 3.1 24 5.5 0.6 3.3 2 0 0 2 2 2 0 HEAT repeat VHS PF00790.19 CDW52924.1 - 2.1e-33 115.1 0.0 3.8e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 CDW52924.1 - 3.7e-15 55.2 0.1 9.4e-15 54.0 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CDW52924.1 - 3.7e-14 52.3 0.1 6.3e-14 51.6 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CDW52924.1 - 1.1e-10 41.0 0.0 2.1e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain UIM PF02809.20 CDW52924.1 - 0.00044 20.0 2.6 0.0012 18.6 2.6 1.8 1 0 0 1 1 1 1 Ubiquitin interaction motif SH3_10 PF17902.1 CDW52924.1 - 0.0042 17.1 0.0 0.012 15.7 0.0 1.8 1 0 0 1 1 1 1 SH3 domain GRIP PF01465.20 CDW52925.1 - 5.2e-09 35.9 1.8 1.6e-08 34.3 1.8 1.9 1 1 0 1 1 1 1 GRIP domain Rab_bind PF16704.5 CDW52925.1 - 1.5e-08 34.5 5.3 3.3e-08 33.4 5.3 1.5 1 0 0 1 1 1 1 Rab binding domain CENP-H PF05837.12 CDW52925.1 - 0.26 11.7 2.9 0.16 12.4 0.8 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Hist_deacetyl PF00850.19 CDW52926.1 - 1.1e-73 248.4 0.0 1.6e-73 247.8 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Myb_DNA-binding PF00249.31 CDW52927.1 - 1.2e-28 99.0 13.4 2.8e-17 62.6 0.2 5.3 6 0 0 6 6 6 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDW52927.1 - 3.4e-21 75.3 3.9 2.5e-14 53.3 0.0 4.4 2 2 2 4 4 4 4 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDW52927.1 - 0.00033 20.5 0.2 0.7 9.8 0.0 3.3 3 0 0 3 3 3 2 Myb DNA-binding like SLIDE PF09111.10 CDW52927.1 - 0.0015 18.5 0.8 0.021 14.9 0.1 3.0 2 1 1 3 3 3 1 SLIDE Rap1_C PF11626.8 CDW52927.1 - 0.013 15.6 1.6 3.9 7.6 1.6 3.0 1 1 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SANT_DAMP1_like PF16282.5 CDW52927.1 - 0.23 11.7 7.0 13 6.1 0.1 4.2 4 1 1 5 5 5 0 SANT/Myb-like domain of DAMP1 Atg29_N PF18388.1 CDW52927.1 - 3.6 7.5 8.7 3.2 7.6 0.4 3.7 4 0 0 4 4 4 0 Atg29 N-terminal domain Arrestin_C PF02752.22 CDW52928.1 - 1.8e-27 96.4 0.0 4.3e-27 95.2 0.0 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CDW52928.1 - 1.2e-24 87.0 0.0 2.4e-21 76.3 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Ribosomal_S16 PF00886.19 CDW52929.1 - 5.8e-16 58.3 0.0 8e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 WD40 PF00400.32 CDW52930.1 - 4.6e-06 27.3 7.8 0.023 15.6 0.0 4.8 4 2 0 4 4 4 2 WD domain, G-beta repeat Ion_trans_2 PF07885.16 CDW52931.1 - 6.3e-14 51.7 15.5 2.2e-12 46.7 6.8 2.6 2 1 0 2 2 2 2 Ion channel DUF3930 PF13067.6 CDW52931.1 - 0.05 13.8 0.0 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3930) Ion_trans PF00520.31 CDW52931.1 - 6.2 6.0 11.3 17 4.5 11.3 1.8 1 1 0 1 1 1 0 Ion transport protein Membr_traf_MHD PF10540.9 CDW52932.1 - 4.8e-46 156.6 2.9 1e-45 155.5 2.9 1.6 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain DUF1041 PF06292.17 CDW52932.1 - 1e-25 90.1 1.9 1e-25 90.1 1.9 3.2 2 1 0 2 2 2 1 Domain of Unknown Function (DUF1041) C2 PF00168.30 CDW52932.1 - 1.4e-19 70.3 0.9 2e-10 40.9 0.0 3.9 4 0 0 4 4 4 3 C2 domain C1_1 PF00130.22 CDW52932.1 - 1.4e-11 44.1 5.5 3.3e-11 42.9 5.5 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DAP3 PF10236.9 CDW52933.1 - 5.1e-57 193.4 0.0 9.4e-57 192.5 0.0 1.4 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 DUF2791 PF10923.8 CDW52933.1 - 0.018 13.9 0.0 0.034 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) AAA_16 PF13191.6 CDW52933.1 - 0.021 15.2 0.0 0.03 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 CDW52933.1 - 0.038 13.7 0.1 0.11 12.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDW52933.1 - 0.053 13.4 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea UQ_con PF00179.26 CDW52934.1 - 1.1e-43 148.2 0.0 1.5e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Sema PF01403.19 CDW52935.1 - 5.4e-126 420.8 0.1 7.1e-126 420.4 0.1 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 CDW52935.1 - 7.7e-07 29.6 1.9 1.9e-06 28.3 1.9 1.6 1 0 0 1 1 1 1 Plexin repeat PSI_integrin PF17205.3 CDW52935.1 - 0.28 11.0 4.2 0.67 9.7 4.2 1.6 1 0 0 1 1 1 0 Integrin plexin domain TPR_14 PF13428.6 CDW52938.1 - 7.8e-07 29.4 0.2 0.46 11.4 0.0 5.7 5 1 1 6 6 5 1 Tetratricopeptide repeat PPR PF01535.20 CDW52938.1 - 2.1e-06 27.6 1.8 1.8 9.0 0.0 6.4 5 2 2 7 7 7 1 PPR repeat PPR_2 PF13041.6 CDW52938.1 - 0.00013 22.1 1.1 4.1 7.7 0.0 5.0 5 0 0 5 5 5 1 PPR repeat family ANAPC3 PF12895.7 CDW52938.1 - 0.0004 20.6 7.0 0.82 9.9 0.5 4.7 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CDW52938.1 - 0.0019 18.2 15.4 0.029 14.6 0.3 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW52938.1 - 0.0046 16.6 1.8 2.8 7.7 0.1 4.6 4 0 0 4 4 4 1 TPR repeat TPR_7 PF13176.6 CDW52938.1 - 0.0047 16.9 6.1 1.6 8.9 0.0 6.2 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW52938.1 - 0.0048 16.9 12.6 0.25 11.6 0.2 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat Clathrin PF00637.20 CDW52938.1 - 0.0094 15.8 9.5 0.24 11.2 0.1 4.3 3 2 2 5 5 5 2 Region in Clathrin and VPS PPR_1 PF12854.7 CDW52938.1 - 0.012 15.3 0.2 5.1 6.9 0.0 3.8 3 1 0 3 3 3 0 PPR repeat TPR_19 PF14559.6 CDW52938.1 - 0.013 16.0 1.6 5.9 7.5 0.6 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat Phage_HK97_TLTM PF06120.11 CDW52938.1 - 0.019 14.2 0.3 0.04 13.1 0.3 1.5 1 0 0 1 1 1 0 Tail length tape measure protein TPR_12 PF13424.6 CDW52938.1 - 0.097 13.0 8.2 3.7 7.9 0.5 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Vps39_1 PF10366.9 CDW52938.1 - 1.2 9.4 10.1 5.3 7.4 0.0 4.4 3 2 1 4 4 4 0 Vacuolar sorting protein 39 domain 1 TPR_1 PF00515.28 CDW52938.1 - 2.6 8.0 13.1 3.2 7.7 0.5 5.3 8 0 0 8 8 8 0 Tetratricopeptide repeat Sel1 PF08238.12 CDW52938.1 - 7.3 7.4 8.1 1.6 9.5 0.1 3.7 4 0 0 4 4 3 0 Sel1 repeat ABC_membrane PF00664.23 CDW52939.1 - 1.4e-129 431.6 80.5 3.7e-43 148.2 15.3 4.9 5 0 0 5 5 5 4 ABC transporter transmembrane region ABC_tran PF00005.27 CDW52939.1 - 5.3e-87 289.3 0.1 8.8e-22 78.1 0.0 5.8 4 2 0 4 4 4 4 ABC transporter SMC_N PF02463.19 CDW52939.1 - 1.4e-12 47.5 20.1 0.015 14.7 0.2 7.7 5 3 0 6 6 6 4 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CDW52939.1 - 3.1e-11 43.3 3.9 0.25 11.4 0.0 4.8 4 0 0 4 4 4 4 50S ribosome-binding GTPase AAA_16 PF13191.6 CDW52939.1 - 3.6e-08 34.0 0.4 2.1 8.7 0.0 4.5 4 0 0 4 4 4 3 AAA ATPase domain AAA_22 PF13401.6 CDW52939.1 - 4.6e-08 33.4 0.6 0.91 9.8 0.0 5.0 4 1 0 4 4 4 2 AAA domain RsgA_GTPase PF03193.16 CDW52939.1 - 4.8e-07 29.8 2.2 0.4 10.6 0.0 4.4 4 0 0 4 4 4 2 RsgA GTPase AAA_29 PF13555.6 CDW52939.1 - 1.3e-06 28.0 1.5 5 6.9 0.0 4.6 4 0 0 4 4 4 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CDW52939.1 - 2.8e-06 27.2 0.1 9.7 5.9 0.0 4.7 4 0 0 4 4 4 0 IstB-like ATP binding protein Dynamin_N PF00350.23 CDW52939.1 - 1.5e-05 25.1 4.9 0.12 12.4 0.0 4.4 4 0 0 4 4 4 2 Dynamin family Zeta_toxin PF06414.12 CDW52939.1 - 2.2e-05 23.8 0.3 2.7 7.2 0.0 4.6 5 0 0 5 5 4 1 Zeta toxin AAA_7 PF12775.7 CDW52939.1 - 0.00091 18.8 1.1 17 4.9 0.0 4.3 4 0 0 4 4 4 0 P-loop containing dynein motor region SbcCD_C PF13558.6 CDW52939.1 - 0.0023 18.2 0.2 66 3.8 0.0 4.7 4 0 0 4 4 4 0 Putative exonuclease SbcCD, C subunit DUF815 PF05673.13 CDW52939.1 - 0.0037 16.5 3.0 9.4 5.3 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF815) AAA PF00004.29 CDW52939.1 - 0.0053 17.2 0.3 3.3 8.1 0.0 4.1 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDW52939.1 - 0.013 16.1 1.6 13 6.3 0.1 4.0 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.22 CDW52939.1 - 0.023 15.1 0.1 35 4.8 0.0 4.5 4 0 0 4 4 4 0 RNA helicase AAA_21 PF13304.6 CDW52939.1 - 0.056 13.2 5.9 59 3.3 0.0 5.2 4 1 1 5 5 5 0 AAA domain, putative AbiEii toxin, Type IV TA system PduV-EutP PF10662.9 CDW52939.1 - 0.058 13.1 4.4 1.5 8.5 0.0 3.7 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 CDW52939.1 - 0.063 12.3 2.7 16 4.3 0.0 3.6 4 0 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Sigma54_activat PF00158.26 CDW52939.1 - 0.098 12.4 0.6 40 3.8 0.0 4.1 4 0 0 4 4 4 0 Sigma-54 interaction domain Roc PF08477.13 CDW52939.1 - 0.1 12.9 4.4 56 4.0 0.0 5.2 5 0 0 5 5 5 0 Ras of Complex, Roc, domain of DAPkinase T2SSE PF00437.20 CDW52939.1 - 0.14 11.2 0.3 20 4.1 0.0 3.7 4 0 0 4 4 4 0 Type II/IV secretion system protein TsaE PF02367.17 CDW52939.1 - 0.15 12.1 1.6 32 4.5 0.0 3.6 4 0 0 4 4 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 CDW52939.1 - 0.23 11.5 18.3 7.1 6.6 0.1 5.1 6 0 0 6 6 4 0 Helicase HerA, central domain AAA_23 PF13476.6 CDW52939.1 - 0.31 11.5 9.6 13 6.2 0.2 4.6 5 0 0 5 5 4 0 AAA domain TrwB_AAD_bind PF10412.9 CDW52939.1 - 0.41 9.5 2.8 18 4.1 0.0 3.5 4 0 0 4 4 4 0 Type IV secretion-system coupling protein DNA-binding domain NB-ARC PF00931.22 CDW52939.1 - 1.4 8.1 7.0 19 4.4 0.1 4.2 5 0 0 5 5 5 0 NB-ARC domain ATP_bind_1 PF03029.17 CDW52939.1 - 4.2 7.1 9.4 68 3.1 0.2 5.1 5 0 0 5 5 5 0 Conserved hypothetical ATP binding protein Sad1_UNC PF07738.13 CDW52940.1 - 7.2e-30 103.7 0.1 2.3e-29 102.0 0.0 1.9 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 CDW52940.1 - 0.056 13.6 0.0 0.21 11.7 0.0 1.9 1 0 0 1 1 1 0 F5/8 type C domain SlyX PF04102.12 CDW52940.1 - 0.14 12.8 0.6 0.31 11.7 0.6 1.6 1 0 0 1 1 1 0 SlyX DUF16 PF01519.16 CDW52940.1 - 0.18 12.3 0.5 0.42 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 PIN_12 PF16289.5 CDW52940.1 - 0.86 10.1 4.1 0.22 12.0 0.4 1.8 2 0 0 2 2 2 0 PIN domain ABC_membrane PF00664.23 CDW52941.1 - 2e-70 237.6 41.4 4.6e-45 154.4 16.2 3.3 3 1 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDW52941.1 - 4e-47 160.2 0.0 1.2e-22 80.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDW52941.1 - 2.6e-09 36.8 4.5 0.005 16.3 0.1 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CDW52941.1 - 4.6e-05 23.5 1.4 0.15 12.1 0.1 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 CDW52941.1 - 0.00078 19.5 0.3 0.021 14.9 0.0 2.7 2 0 0 2 2 2 1 Dynamin family AAA_29 PF13555.6 CDW52941.1 - 0.0012 18.5 0.1 0.84 9.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CDW52941.1 - 0.0013 19.0 1.9 1.3 9.3 0.2 3.5 3 1 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 CDW52941.1 - 0.0028 17.4 0.3 1.8 8.3 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_16 PF13191.6 CDW52941.1 - 0.0044 17.4 0.2 4.7 7.6 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CDW52941.1 - 0.0056 16.6 0.1 1.6 8.6 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 CDW52941.1 - 0.0066 16.3 1.9 12 5.6 0.1 3.7 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 CDW52941.1 - 0.027 14.6 5.0 0.98 9.5 0.5 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain T2SSE PF00437.20 CDW52941.1 - 0.054 12.5 0.1 0.49 9.4 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_18 PF13238.6 CDW52941.1 - 0.073 13.6 0.2 2.9 8.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDW52941.1 - 0.1 11.9 0.0 4.2 6.6 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin KH_2 PF07650.17 CDW52941.1 - 0.23 11.3 1.3 4.9 7.1 0.0 3.1 3 0 0 3 3 3 0 KH domain Aminotran_5 PF00266.19 CDW52942.1 - 3.1e-28 98.8 0.0 3.7e-28 98.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V PI3K_P85_iSH2 PF16454.5 CDW52943.1 - 0.053 13.1 0.3 0.071 12.7 0.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain IPK PF03770.16 CDW52945.1 - 7e-38 130.5 0.7 2.4e-37 128.7 0.7 1.8 1 1 0 1 1 1 1 Inositol polyphosphate kinase Transcrip_act PF04949.13 CDW52945.1 - 0.017 15.0 1.1 0.025 14.5 1.1 1.2 1 0 0 1 1 1 0 Transcriptional activator CrgA PF06781.12 CDW52946.1 - 0.38 10.9 0.0 0.38 10.9 0.0 3.0 2 1 0 2 2 2 0 Cell division protein CrgA LAP1C PF05609.12 CDW52946.1 - 0.59 9.2 24.0 0.93 8.5 24.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) EVI2A PF05399.11 CDW52946.1 - 1.2 8.7 9.9 0.39 10.3 0.3 2.3 1 1 1 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) CRT10 PF08728.10 CDW52946.1 - 3.6 5.6 11.6 4.4 5.4 11.6 1.2 1 0 0 1 1 1 0 CRT10 Brix PF04427.18 CDW52947.1 - 1.6e-32 113.2 0.2 2.6e-32 112.5 0.2 1.3 1 0 0 1 1 1 1 Brix domain Lig_chan PF00060.26 CDW52948.1 - 1.8e-52 177.1 0.2 2.7e-52 176.6 0.2 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 CDW52948.1 - 5.3e-42 142.6 0.0 1e-41 141.7 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.28 CDW52948.1 - 8.7e-27 94.1 0.2 1.2e-26 93.7 0.2 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.20 CDW52948.1 - 5.9e-20 71.7 0.0 1.4e-19 70.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 AAA_27 PF13514.6 CDW52948.1 - 0.04 13.5 0.1 0.077 12.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain Ion_trans_2 PF07885.16 CDW52948.1 - 6.3 6.8 9.6 0.28 11.2 2.7 2.4 2 1 0 2 2 2 0 Ion channel Mito_carr PF00153.27 CDW52949.1 - 3.5e-35 119.8 2.2 1.6e-14 53.6 0.1 3.6 3 2 0 3 3 3 3 Mitochondrial carrier protein UQ_con PF00179.26 CDW52950.1 - 7.9e-51 171.4 0.0 8.9e-51 171.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pkinase PF00069.25 CDW52951.1 - 7.3e-62 209.1 0.0 9.1e-62 208.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW52951.1 - 1.2e-44 152.6 0.0 1.6e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 CDW52951.1 - 5.1e-17 61.8 0.1 1.2e-16 60.7 0.1 1.7 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Kinase-like PF14531.6 CDW52951.1 - 0.00017 21.0 0.0 0.0003 20.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDW52951.1 - 0.00019 20.3 0.0 0.00038 19.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF4290 PF14123.6 CDW52951.1 - 0.065 12.8 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) Histone_H2A_C PF16211.5 CDW52952.1 - 1.2e-19 69.8 0.4 1.7e-19 69.3 0.4 1.2 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW52952.1 - 0.0066 16.8 0.2 0.0094 16.3 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW52953.1 - 3.9e-08 33.4 0.1 4.9e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW52953.1 - 2.7e-05 24.5 0.1 3.5e-05 24.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW52953.1 - 5.1e-05 23.5 0.1 8.9e-05 22.7 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW52953.1 - 6.3e-05 23.1 0.1 8.9e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 CDW52953.1 - 0.00011 22.5 0.2 0.00012 22.4 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 CDW52953.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 CDW52953.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 CDW52953.1 - 0.15 12.6 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 CDW52954.1 - 1.7e-50 170.7 3.7 1.9e-50 170.6 3.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW52954.1 - 6.7e-05 23.5 0.8 7.8e-05 23.3 0.8 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW52954.1 - 7e-05 22.9 0.8 0.00011 22.3 0.2 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW52954.1 - 0.0024 18.2 0.1 0.0038 17.6 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW52954.1 - 0.015 15.4 0.2 0.031 14.4 0.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW52954.1 - 0.05 13.9 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Collagen PF01391.18 CDW52955.1 - 3.3e-20 71.6 93.5 7.5e-10 38.4 29.4 4.6 4 1 0 4 4 4 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW52955.1 - 6e-12 45.4 0.1 3.7e-11 42.9 0.0 2.1 2 0 0 2 2 2 1 Nematode cuticle collagen N-terminal domain PAS_11 PF14598.6 CDW52956.1 - 1.1e-10 41.6 0.1 2.1e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 CDW52956.1 - 2.5e-09 37.3 0.0 9e-06 25.9 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 CDW52956.1 - 0.00032 20.9 0.0 0.83 9.9 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 CDW52956.1 - 0.00064 19.7 0.0 0.2 11.7 0.0 2.5 2 0 0 2 2 2 2 PAS fold Fucokinase PF07959.12 CDW52956.1 - 0.16 10.9 0.1 0.16 10.9 0.1 1.9 3 0 0 3 3 3 0 L-fucokinase SLC12 PF03522.15 CDW52957.1 - 2.4e-130 435.4 0.0 3e-130 435.1 0.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.21 CDW52957.1 - 1.5e-97 327.1 31.7 1.9e-97 326.9 31.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_N PF08403.10 CDW52957.1 - 1.1e-08 34.4 0.0 1.3e-07 31.0 0.1 2.3 2 0 0 2 2 2 1 Amino acid permease N-terminal Lipocalin PF00061.23 CDW52958.1 - 4.3e-08 33.5 0.0 5.6e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 CDW52958.1 - 0.036 14.0 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family DUF4897 PF16238.5 CDW52958.1 - 0.1 12.4 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4897) DUF5039 PF16442.5 CDW52960.1 - 0.0038 16.8 0.6 0.0061 16.1 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5039) EGF_2 PF07974.13 CDW52960.1 - 2.8 8.4 13.0 0.087 13.2 2.4 3.4 2 0 0 2 2 2 0 EGF-like domain YIF1 PF03878.15 CDW52961.1 - 1.2e-68 231.2 6.7 1.5e-68 230.9 6.7 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 CDW52961.1 - 0.0023 17.7 10.9 0.0023 17.7 10.9 1.9 1 1 1 2 2 2 1 Yip1 domain MarC PF01914.17 CDW52961.1 - 0.0079 15.6 0.1 0.015 14.7 0.1 1.5 1 1 0 1 1 1 1 MarC family integral membrane protein DUF2389 PF09493.10 CDW52962.1 - 0.16 12.6 0.1 8.4 7.1 0.0 2.5 2 0 0 2 2 2 0 Tryptophan-rich protein (DUF2389) Proteasome PF00227.26 CDW52963.1 - 4.6e-30 104.5 0.0 5.7e-18 65.1 0.0 2.0 1 1 1 2 2 2 2 Proteasome subunit DUF3456 PF11938.8 CDW52964.1 - 5.1e-11 43.3 1.8 2.9e-05 24.6 0.9 2.4 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP EGF_CA PF07645.15 CDW52964.1 - 1.3e-06 28.5 8.6 1.3e-06 28.5 8.6 4.6 4 1 1 5 5 5 1 Calcium-binding EGF domain EGF_2 PF07974.13 CDW52964.1 - 0.0096 16.3 11.2 0.0096 16.3 11.2 4.9 4 1 0 4 4 4 1 EGF-like domain Laminin_EGF PF00053.24 CDW52964.1 - 0.019 15.1 13.4 0.019 15.1 13.4 5.3 2 1 3 5 5 5 0 Laminin EGF domain hEGF PF12661.7 CDW52964.1 - 0.041 14.5 0.4 0.041 14.5 0.4 4.9 4 1 0 4 4 4 0 Human growth factor-like EGF cEGF PF12662.7 CDW52964.1 - 2.5 8.1 23.3 1.5 8.8 4.2 4.1 3 1 0 3 3 3 0 Complement Clr-like EGF-like Ion_trans_2 PF07885.16 CDW52965.1 - 2e-17 62.9 1.3 2e-17 62.9 1.3 2.4 3 0 0 3 3 3 1 Ion channel Ion_trans PF00520.31 CDW52965.1 - 0.00039 19.7 1.0 0.00087 18.6 1.1 1.7 1 1 0 1 1 1 1 Ion transport protein DUF805 PF05656.14 CDW52965.1 - 3.2 8.2 7.4 12 6.3 7.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF805) DNA_pol_A_exo1 PF01612.20 CDW52966.1 - 0.0023 17.7 0.0 0.018 14.7 0.0 2.0 2 0 0 2 2 2 1 3'-5' exonuclease DUF4743 PF15916.5 CDW52966.1 - 0.024 14.6 0.0 3.7 7.5 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4743) Thioredoxin_16 PF18569.1 CDW52966.1 - 0.16 12.1 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Ribosomal_S24e PF01282.19 CDW52967.1 - 1.9e-31 107.8 0.9 2.1e-31 107.7 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S24e Pro_CA PF00484.19 CDW52968.1 - 8.5e-27 94.4 0.0 1.2e-26 93.9 0.0 1.2 1 0 0 1 1 1 1 Carbonic anhydrase GLTSCR1 PF15249.6 CDW52969.1 - 2.2e-21 76.2 1.3 4.6e-21 75.2 0.2 2.2 2 0 0 2 2 2 1 Conserved region of unknown function on GLTSCR protein ShK PF01549.24 CDW52970.1 - 4.3e-06 27.2 6.6 4.3e-06 27.2 6.6 2.2 2 1 1 3 3 3 1 ShK domain-like DUF1794 PF08768.11 CDW52970.1 - 5.6e-06 26.4 0.0 8.4e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) EGF_2 PF07974.13 CDW52970.1 - 0.021 15.2 11.2 0.021 15.2 11.2 2.2 3 0 0 3 3 3 0 EGF-like domain Ank_2 PF12796.7 CDW52971.1 - 1.8e-38 131.0 3.3 1.6e-11 44.6 0.8 4.7 4 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW52971.1 - 4.3e-35 119.6 13.8 3.2e-10 40.3 0.1 6.1 4 2 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW52971.1 - 1.6e-26 89.5 8.0 0.0003 21.0 0.0 8.6 9 0 0 9 9 9 5 Ankyrin repeat Ank PF00023.30 CDW52971.1 - 1.9e-22 78.7 13.3 4.3e-05 23.8 0.0 9.4 9 0 0 9 9 9 5 Ankyrin repeat Ank_5 PF13857.6 CDW52971.1 - 2.9e-19 68.9 11.5 7.6e-06 26.1 0.2 5.7 3 2 3 6 6 6 4 Ankyrin repeats (many copies) RRM_1 PF00076.22 CDW52971.1 - 9.3e-12 44.6 0.0 2.4e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.27 CDW52971.1 - 3e-09 36.4 1.7 6.9e-09 35.3 1.7 1.6 1 0 0 1 1 1 1 SAP domain RRM_5 PF13893.6 CDW52971.1 - 0.046 13.3 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XAP5 PF04921.14 CDW52972.1 - 7.9e-77 258.4 8.5 7.9e-77 258.4 8.5 1.6 1 1 1 2 2 2 1 XAP5, circadian clock regulator Gemin6 PF06372.12 CDW52972.1 - 0.17 11.4 2.7 1.4 8.4 0.4 2.5 2 0 0 2 2 2 0 Gemin6 protein UPF0564 PF10595.9 CDW52973.1 - 2e-18 66.6 23.6 2e-13 50.2 1.1 2.3 2 0 0 2 2 2 2 Uncharacterised protein family UPF0564 DUF1090 PF06476.12 CDW52973.1 - 0.015 15.4 0.4 0.015 15.4 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) FEZ PF07763.13 CDW52974.1 - 1.4e-71 241.0 10.8 5e-70 236.0 10.8 2.1 1 1 0 1 1 1 1 FEZ-like protein DUF5102 PF17104.5 CDW52974.1 - 0.021 14.9 3.3 1.2 9.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5102) SCHIP-1 PF10148.9 CDW52974.1 - 0.13 11.8 1.5 0.15 11.6 0.1 1.7 2 0 0 2 2 2 0 Schwannomin-interacting protein 1 CRM1_C PF08767.11 CDW52975.1 - 4.9e-115 384.1 3.6 4.9e-115 384.1 3.6 2.9 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 CDW52975.1 - 1.7e-38 132.0 3.7 1.7e-38 132.0 3.7 3.9 3 1 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 CDW52975.1 - 1.8e-34 117.1 1.3 6e-34 115.5 1.3 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 CDW52975.1 - 6.3e-29 99.9 1.8 7.7e-28 96.4 1.2 3.0 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 CDW52975.1 - 2.4e-18 65.3 4.8 5.7e-18 64.1 4.8 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 CDW52975.1 - 2.5e-15 56.2 0.8 1.4e-14 53.7 0.1 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain PBP PF01161.20 CDW52976.1 - 4.2e-14 53.0 0.0 4.8e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein CLTH PF10607.9 CDW52977.1 - 1e-23 83.9 0.4 1.7e-23 83.2 0.4 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SapB_1 PF05184.15 CDW52977.1 - 0.084 12.9 0.5 0.23 11.5 0.1 2.0 2 0 0 2 2 2 0 Saposin-like type B, region 1 DSPc PF00782.20 CDW52978.1 - 3.5e-36 124.0 0.0 6e-36 123.2 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW52978.1 - 0.0039 16.8 0.0 0.0073 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CyRPA PF18638.1 CDW52978.1 - 0.0092 15.2 0.0 0.02 14.0 0.0 1.5 1 0 0 1 1 1 1 Cysteine-Rich Protective Antigen 6 bladed domain DUF1617 PF07761.12 CDW52979.1 - 0.0097 16.0 2.6 37 4.4 0.0 3.9 4 0 0 4 4 4 3 Protein of unknown function (DUF1617) Glyco_transf_7N PF13733.6 CDW52979.1 - 0.096 12.3 1.0 30 4.2 0.0 3.1 3 0 0 3 3 3 0 N-terminal region of glycosyl transferase group 7 DUF134 PF02001.16 CDW52979.1 - 0.28 11.8 2.7 2.1e+02 2.6 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function DUF134 Metallothio_Euk PF12749.7 CDW52979.1 - 1.8 8.8 19.3 5.2 7.3 1.5 3.3 3 0 0 3 3 3 0 Eukaryotic metallothionein DUF1617 PF07761.12 CDW52980.1 - 5.1e-05 23.4 7.6 59 3.7 0.0 6.1 6 0 0 6 6 6 1 Protein of unknown function (DUF1617) Glyco_transf_7N PF13733.6 CDW52980.1 - 0.02 14.5 6.7 50 3.5 0.0 5.6 6 0 0 6 6 6 0 N-terminal region of glycosyl transferase group 7 zf-ACC PF17848.1 CDW52980.1 - 1.5 9.0 10.7 2.9e+02 1.6 0.0 6.1 6 0 0 6 6 6 0 Acetyl-coA carboxylase zinc finger domain Dimer_Tnp_hAT PF05699.14 CDW52981.1 - 0.0015 18.3 0.1 0.0026 17.5 0.1 1.4 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region Ribosomal_L7Ae PF01248.26 CDW52982.1 - 5.7e-12 45.2 0.2 7.7e-12 44.8 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Recep_L_domain PF01030.24 CDW52984.1 - 1.7e-45 153.7 3.7 5.5e-25 87.7 0.1 2.9 3 0 0 3 3 3 2 Receptor L domain Furin-like PF00757.20 CDW52984.1 - 3.5e-26 91.9 36.1 1.1e-25 90.3 36.1 1.9 1 0 0 1 1 1 1 Furin-like cysteine rich region fn3 PF00041.21 CDW52984.1 - 1.8e-21 76.2 0.9 2.5e-05 24.6 0.0 4.5 4 0 0 4 4 4 4 Fibronectin type III domain Pkinase_Tyr PF07714.17 CDW52984.1 - 1.2e-18 67.3 0.0 2.1e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW52984.1 - 1.7e-11 44.0 0.0 2.7e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain GF_recep_IV PF14843.6 CDW52984.1 - 0.0066 16.2 18.0 0.0066 16.2 18.0 2.8 1 1 1 2 2 2 1 Growth factor receptor domain IV Pur_ac_phosph_N PF16656.5 CDW52984.1 - 0.27 11.8 1.7 21 5.8 0.0 3.5 4 0 0 4 4 4 0 Purple acid Phosphatase, N-terminal domain Runt PF00853.19 CDW52985.1 - 1.1e-58 196.4 0.0 1.7e-58 195.8 0.0 1.2 1 0 0 1 1 1 1 Runt domain LIM PF00412.22 CDW52987.1 - 7.5e-11 42.1 9.0 2.5e-10 40.4 9.1 1.7 1 1 1 2 2 2 2 LIM domain zf_C2H2_13 PF18508.1 CDW52987.1 - 0.039 13.5 0.7 8.6 6.0 0.2 2.3 2 0 0 2 2 2 0 Zinc finger domain zf-C4pol PF14260.6 CDW52987.1 - 0.061 13.8 3.3 0.94 10.0 4.6 1.9 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Vps36-NZF-N PF16988.5 CDW52987.1 - 0.13 11.7 4.0 0.31 10.4 0.2 2.1 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DZR PF12773.7 CDW52987.1 - 0.19 11.8 8.3 10 6.3 8.3 2.6 1 1 0 1 1 1 0 Double zinc ribbon DUF3039 PF11238.8 CDW52987.1 - 1.9 8.3 7.5 5.8 6.7 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3039) zf-C2H2 PF00096.26 CDW52987.1 - 5.9 7.5 10.0 1.7 9.3 0.6 2.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type RGS PF00615.19 CDW52988.1 - 1.1e-33 116.0 2.6 1.2e-33 115.8 2.6 1.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain LEDGF PF11467.8 CDW52988.1 - 0.054 13.1 0.2 0.079 12.6 0.2 1.4 1 1 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) Fe_hyd_lg_C PF02906.14 CDW52988.1 - 0.1 12.3 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain Dus PF01207.17 CDW52989.1 - 4.5e-64 216.5 0.0 7.5e-64 215.8 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Jagunal PF07086.12 CDW52990.1 - 1.7e-62 210.8 4.4 1.9e-62 210.7 4.4 1.0 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis Neur_chan_LBD PF02931.23 CDW52991.1 - 7.4e-13 48.4 0.1 1.1e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF3382 PF11862.8 CDW52991.1 - 0.067 13.5 0.1 0.21 11.9 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3382) zf-C2H2 PF00096.26 CDW52993.1 - 7.8e-43 142.6 95.2 0.00081 19.7 0.7 14.3 14 0 0 14 14 14 11 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW52993.1 - 4.3e-38 126.7 95.6 0.00086 20.0 0.4 14.3 14 0 0 14 14 14 12 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW52993.1 - 9.5e-30 101.7 89.4 8.9e-07 29.1 0.8 14.8 16 0 0 16 16 15 9 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW52993.1 - 7.3e-18 64.4 64.9 0.00094 19.4 0.0 14.0 14 0 0 14 14 14 8 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW52993.1 - 5.7e-14 52.0 65.1 0.011 16.1 0.4 13.4 14 0 0 14 14 14 8 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CDW52993.1 - 1.9e-11 43.7 74.7 0.0013 18.6 0.0 12.4 13 0 0 13 13 13 8 C2H2-type zinc finger zf-Di19 PF05605.12 CDW52993.1 - 2.3e-06 27.8 68.1 0.0033 17.7 2.7 9.3 4 1 6 10 10 10 7 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CDW52993.1 - 6e-05 23.3 55.4 0.68 10.3 2.4 10.5 2 2 6 8 8 8 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 CDW52993.1 - 0.0034 17.1 4.4 0.016 15.0 0.9 8.8 10 0 0 10 10 10 2 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 CDW52993.1 - 0.0072 17.0 42.0 0.48 11.2 0.8 7.3 5 2 2 7 7 7 3 zinc-ribbon family GAGA PF09237.11 CDW52993.1 - 0.0098 15.7 12.7 6.3 6.7 0.3 5.3 2 2 3 5 5 5 1 GAGA factor zf-trcl PF13451.6 CDW52993.1 - 0.013 15.4 2.0 0.013 15.4 2.0 8.0 11 0 0 11 11 10 0 Probable zinc-ribbon domain zf_UBZ PF18439.1 CDW52993.1 - 0.12 11.9 45.5 2.6 7.7 0.0 10.7 12 0 0 12 12 12 0 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 CDW52993.1 - 0.77 9.7 0.0 0.77 9.7 0.0 9.5 10 0 0 10 10 9 0 zinc-finger of a C2HC-type Trm112p PF03966.16 CDW52993.1 - 2 9.1 18.2 6.9 7.3 0.3 6.3 5 2 0 5 5 5 0 Trm112p-like protein BRICHOS PF04089.14 CDW52994.1 - 0.024 14.9 0.5 0.073 13.3 0.2 1.9 2 0 0 2 2 2 0 BRICHOS domain DsrD PF08679.11 CDW52994.1 - 0.078 13.3 0.8 0.62 10.4 0.1 2.7 3 0 0 3 3 3 0 Dissimilatory sulfite reductase D (DsrD) DUF2573 PF10835.8 CDW52994.1 - 0.12 12.7 3.1 5.6 7.4 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2573) mRNA_cap_enzyme PF01331.19 CDW52995.1 - 5.3e-54 183.0 0.0 1.7e-53 181.4 0.0 1.7 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 CDW52995.1 - 1e-15 58.3 0.0 2e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 CDW52995.1 - 1.1e-06 28.4 0.0 0.0028 17.4 0.0 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain MRI PF15325.6 CDW52995.1 - 0.13 13.3 0.2 0.24 12.5 0.2 1.4 1 0 0 1 1 1 0 Modulator of retrovirus infection Ank_4 PF13637.6 CDW52996.1 - 6.4e-09 36.2 1.1 0.00032 21.2 0.2 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW52996.1 - 3.1e-08 33.7 0.0 3.8e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW52996.1 - 2.8e-06 27.2 0.2 3.9e-06 26.8 0.2 1.2 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.30 CDW52996.1 - 3.8e-05 23.9 0.2 4.9e-05 23.6 0.2 1.2 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 CDW52996.1 - 0.00014 22.4 0.0 0.00015 22.3 0.0 1.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) TPP_enzyme_M PF00205.22 CDW52996.1 - 0.13 12.0 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain PCI PF01399.27 CDW52997.1 - 1.3e-09 38.5 0.3 4.3e-08 33.6 0.1 2.4 2 0 0 2 2 2 1 PCI domain DUF4790 PF16037.5 CDW52997.1 - 0.0035 17.8 0.0 1 9.8 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4790) Urb2 PF10441.9 CDW52997.1 - 0.016 15.1 1.1 0.26 11.2 0.3 2.2 2 0 0 2 2 2 0 Urb2/Npa2 family CSN8_PSD8_EIF3K PF10075.9 CDW52997.1 - 0.021 14.8 0.0 0.053 13.5 0.0 1.7 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family GGGtGRT PF14057.6 CDW52997.1 - 0.19 10.7 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 GGGtGRT protein Ig_3 PF13927.6 CDW52998.1 - 2.2e-22 79.5 0.2 1.6e-11 44.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 CDW52998.1 - 2.1e-19 69.4 0.0 3.3e-10 39.9 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW52998.1 - 1e-16 61.0 0.2 2.8e-09 37.2 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 CDW52998.1 - 1e-14 54.5 0.1 3.4e-06 27.2 0.1 2.3 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 CDW52998.1 - 1.1e-05 25.5 0.1 0.019 15.2 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin V-set domain BiPBP_C PF06832.12 CDW52998.1 - 0.0071 16.4 0.0 0.032 14.2 0.0 1.9 2 0 0 2 2 2 1 Penicillin-Binding Protein C-terminus Family Ig_6 PF18452.1 CDW52998.1 - 0.025 14.1 0.0 0.24 11.0 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain Ig_4 PF16680.5 CDW52998.1 - 0.071 13.4 0.0 0.32 11.3 0.0 1.9 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain Pkinase_Tyr PF07714.17 CDW52999.1 - 1.6e-63 214.4 0.0 2.2e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ig_3 PF13927.6 CDW52999.1 - 3.2e-45 152.6 0.0 1.1e-13 51.6 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 CDW52999.1 - 3.7e-43 145.5 0.5 5.2e-13 48.9 0.0 5.2 4 1 0 4 4 4 4 Immunoglobulin I-set domain Pkinase PF00069.25 CDW52999.1 - 1.6e-31 109.6 0.0 2.3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ig_2 PF13895.6 CDW52999.1 - 8.6e-31 106.1 0.0 1.9e-08 34.5 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 CDW52999.1 - 1.6e-30 105.1 0.1 2.1e-08 34.2 0.0 5.3 4 1 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 CDW52999.1 - 7.3e-19 68.0 4.0 2.8e-07 30.7 0.1 6.4 4 3 1 5 5 5 4 Immunoglobulin V-set domain Ig_6 PF18452.1 CDW52999.1 - 3.9e-14 51.9 0.0 0.0014 18.2 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain Izumo-Ig PF16706.5 CDW52999.1 - 3.6e-06 27.0 2.0 2.4 8.3 0.1 5.2 4 2 0 4 4 4 2 Izumo-like Immunoglobulin domain C2-set_2 PF08205.12 CDW52999.1 - 0.00028 20.9 0.8 16 5.7 0.0 4.1 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 CDW52999.1 - 0.075 13.2 0.1 39 4.5 0.0 3.4 2 1 1 3 3 3 0 Natural killer cell receptor 2B4 IBR PF01485.21 CDW53000.1 - 3.7e-18 65.5 51.8 1.2e-12 47.9 11.9 4.5 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 CDW53000.1 - 0.00026 21.3 2.5 0.00026 21.3 2.5 4.7 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW53000.1 - 0.00079 19.2 1.6 0.00079 19.2 1.6 4.8 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) UBA_4 PF14555.6 CDW53000.1 - 0.00092 19.0 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain zf-RING_5 PF14634.6 CDW53000.1 - 0.00097 19.0 3.6 0.00097 19.0 3.6 3.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDW53000.1 - 0.0045 17.0 2.2 0.0045 17.0 2.2 3.9 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDW53000.1 - 0.018 15.2 0.5 0.018 15.2 0.5 4.3 3 1 0 3 3 3 0 zinc finger of C3HC4-type, RING PAS_3 PF08447.12 CDW53001.1 - 2.9e-12 46.7 0.0 5.9e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 CDW53001.1 - 1.2e-08 35.0 0.0 2.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDW53001.1 - 0.0017 18.3 0.0 0.004 17.1 0.0 1.6 1 0 0 1 1 1 1 PAS fold Ldh_1_N PF00056.23 CDW53003.1 - 3.5e-35 121.2 0.2 5.2e-35 120.6 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDW53003.1 - 1e-34 119.9 0.0 1.5e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Neur_chan_LBD PF02931.23 CDW53004.1 - 1.4e-42 145.6 0.1 1.9e-42 145.2 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW53004.1 - 5.1e-21 75.8 0.1 6.8e-21 75.4 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Memo PF01875.17 CDW53005.1 - 5.2e-88 294.7 0.0 6e-88 294.5 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Yip1 PF04893.17 CDW53006.1 - 1.1e-12 48.0 15.5 1.7e-12 47.4 14.1 1.9 1 1 1 2 2 2 1 Yip1 domain Alpha-amylase_C PF02806.18 CDW53007.1 - 5.7e-24 84.4 0.0 2e-23 82.7 0.0 2.0 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 CDW53007.1 - 2.2e-14 53.5 0.0 5.9e-14 52.2 0.0 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CDW53007.1 - 9.6e-11 41.8 0.9 1.6e-07 31.2 0.1 2.2 1 1 1 2 2 2 2 Alpha amylase, catalytic domain TAF8_C PF10406.9 CDW53008.1 - 7.9e-12 45.6 0.1 1.6e-11 44.6 0.1 1.5 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 CDW53008.1 - 8.2e-08 32.1 0.0 2.2e-07 30.8 0.0 1.7 2 0 0 2 2 2 1 Bromodomain associated Histone PF00125.24 CDW53008.1 - 0.061 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Bromo_TP_like PF17027.5 CDW53008.1 - 0.069 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Histone-fold protein EGF_2 PF07974.13 CDW53010.1 - 3.5e-05 24.1 0.3 8e-05 22.9 0.3 1.6 1 1 0 1 1 1 1 EGF-like domain EGF PF00008.27 CDW53010.1 - 5.8e-05 23.3 0.5 0.00031 21.0 0.5 2.1 1 1 0 1 1 1 1 EGF-like domain Adeno_GP19K PF04881.13 CDW53010.1 - 0.0063 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Adenovirus GP19K hEGF PF12661.7 CDW53010.1 - 0.02 15.5 2.4 0.32 11.7 2.4 2.5 1 1 0 1 1 1 0 Human growth factor-like EGF FixQ PF05545.11 CDW53010.1 - 0.031 14.2 0.7 0.055 13.4 0.7 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Herpes_gE PF02480.16 CDW53010.1 - 0.091 11.5 0.8 3.5 6.3 0.0 2.0 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Laminin_EGF PF00053.24 CDW53010.1 - 0.15 12.2 1.9 0.32 11.2 1.9 1.5 1 1 0 1 1 1 0 Laminin EGF domain DUF3844 PF12955.7 CDW53010.1 - 0.24 11.6 1.2 0.56 10.4 1.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3844) DUF5385 PF17359.2 CDW53010.1 - 0.28 10.7 0.1 0.46 10.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Stevor PF17410.2 CDW53010.1 - 0.42 10.1 2.5 0.62 9.6 2.5 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Ly-6_related PF06579.12 CDW53011.1 - 2e-27 95.9 1.3 2.4e-27 95.6 1.3 1.1 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein BTB PF00651.31 CDW53012.1 - 4.9e-10 39.6 0.0 0.0045 17.2 0.0 3.5 3 1 0 3 3 3 2 BTB/POZ domain BACK PF07707.15 CDW53012.1 - 2.9e-08 33.7 0.1 1.1e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch PRK PF00485.18 CDW53013.1 - 1e-45 155.9 0.0 1.2e-45 155.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Cytidylate_kin PF02224.18 CDW53013.1 - 8e-06 25.7 0.0 0.017 14.8 0.0 2.1 2 0 0 2 2 2 2 Cytidylate kinase AAA_18 PF13238.6 CDW53013.1 - 8.3e-06 26.4 0.4 6e-05 23.6 0.4 2.0 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 CDW53013.1 - 0.00016 21.4 0.1 0.037 13.7 0.0 2.3 2 0 0 2 2 2 2 Dephospho-CoA kinase AAA_17 PF13207.6 CDW53013.1 - 0.00024 21.5 0.4 0.27 11.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CDW53013.1 - 0.0031 17.7 0.0 0.0082 16.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CDW53013.1 - 0.0068 15.7 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.17 CDW53013.1 - 0.095 12.4 0.4 4.7 6.8 0.1 2.2 2 0 0 2 2 2 0 Thymidylate kinase T2SSE PF00437.20 CDW53013.1 - 0.21 10.6 0.5 0.46 9.5 0.3 1.6 1 1 1 2 2 2 0 Type II/IV secretion system protein Ras PF00071.22 CDW53014.1 - 3.2e-67 225.2 0.3 3.7e-67 224.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW53014.1 - 2.1e-37 128.0 0.3 4.4e-37 127.0 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW53014.1 - 7e-17 61.4 0.1 8.5e-17 61.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CDW53014.1 - 1.4e-06 28.3 0.2 0.022 14.6 0.1 2.3 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 CDW53014.1 - 1.3e-05 24.7 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDW53014.1 - 1.8e-05 24.2 0.0 2.1e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDW53014.1 - 1.9e-05 24.3 0.1 5.5e-05 22.8 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW53014.1 - 3.3e-05 23.9 0.0 5.7e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW53014.1 - 0.0041 16.7 0.0 0.051 13.1 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_7 PF12775.7 CDW53014.1 - 0.03 13.8 0.0 0.18 11.3 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 CDW53014.1 - 0.031 14.7 0.0 0.043 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 CDW53014.1 - 0.034 13.9 0.1 1.3 8.8 0.0 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 CDW53014.1 - 0.04 14.3 0.0 0.45 10.9 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW53014.1 - 0.061 13.6 0.0 0.14 12.4 0.0 1.8 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CDW53014.1 - 0.073 12.8 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 CDW53014.1 - 0.084 12.9 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.18 CDW53014.1 - 0.096 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Septin TniB PF05621.11 CDW53014.1 - 0.12 11.7 0.0 0.33 10.3 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein Kunitz_BPTI PF00014.23 CDW53015.1 - 1.8e-197 639.7 164.3 1.9e-20 72.8 5.1 13.4 12 0 0 12 12 12 11 Kunitz/Bovine pancreatic trypsin inhibitor domain ADAM_spacer1 PF05986.14 CDW53015.1 - 1.4e-33 115.4 0.0 2.3e-33 114.6 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 CDW53015.1 - 1.6e-27 95.4 78.6 1.3e-05 25.3 8.5 9.8 7 0 0 7 7 7 6 Thrombospondin type 1 domain PLAC PF08686.11 CDW53015.1 - 5.1e-10 39.9 9.4 6.4e-09 36.4 9.4 3.3 1 0 0 1 1 1 1 PLAC (protease and lacunin) domain Ig_3 PF13927.6 CDW53015.1 - 1.5e-05 25.5 0.0 0.00014 22.4 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 CDW53015.1 - 0.00034 20.8 1.1 0.04 14.1 0.0 4.3 4 1 0 4 4 4 1 Immunoglobulin V-set domain I-set PF07679.16 CDW53015.1 - 0.0017 18.4 0.0 0.0043 17.1 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 CDW53015.1 - 0.016 15.4 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain DUF4028 PF13220.6 CDW53015.1 - 0.084 12.6 0.0 0.31 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) Homeodomain PF00046.29 CDW53016.1 - 1.9e-20 72.4 5.8 3.3e-20 71.7 5.8 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW53016.1 - 0.013 15.4 0.1 0.026 14.4 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain WD40 PF00400.32 CDW53019.1 - 8.7e-22 77.0 11.1 4.1e-06 27.4 0.0 6.0 5 0 0 5 5 5 4 WD domain, G-beta repeat F-box PF00646.33 CDW53019.1 - 4.1e-10 39.3 0.9 4.1e-10 39.3 0.9 2.3 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CDW53019.1 - 8.5e-10 38.4 2.1 8.7e-10 38.3 0.4 2.0 2 0 0 2 2 2 1 F-box-like Kdo PF06293.14 CDW53019.1 - 1.1e-07 31.5 0.0 2.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CDW53019.1 - 1.3e-07 31.3 0.0 2.8e-07 30.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 CDW53019.1 - 1.2e-06 28.3 0.0 2.5e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CDW53019.1 - 2.1e-05 24.6 0.0 0.025 14.5 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Nup160 PF11715.8 CDW53019.1 - 0.0002 20.2 9.8 0.25 10.0 0.2 3.9 2 2 2 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CDW53019.1 - 0.00022 21.5 1.2 0.048 14.0 0.1 3.5 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain EcKinase PF02958.20 CDW53019.1 - 0.0004 19.8 0.0 0.00069 19.0 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase WD40_like PF17005.5 CDW53019.1 - 0.0028 17.0 0.5 0.061 12.7 0.0 2.5 2 1 0 2 2 2 1 WD40-like domain F-box_4 PF15966.5 CDW53019.1 - 0.0039 17.1 0.1 0.011 15.6 0.1 1.8 1 0 0 1 1 1 1 F-box Pkinase_Tyr PF07714.17 CDW53019.1 - 0.0046 16.3 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1679 PF07914.11 CDW53019.1 - 0.012 14.5 0.0 0.038 12.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Pkinase_fungal PF17667.1 CDW53019.1 - 0.028 13.2 0.2 0.16 10.7 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Aquarius_N PF16399.5 CDW53020.1 - 1.3e-273 909.9 8.2 2.7e-170 568.1 0.1 3.0 2 1 0 2 2 2 2 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 CDW53020.1 - 8.2e-28 97.9 0.0 2.9e-27 96.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 CDW53020.1 - 3.6e-26 92.0 0.0 9e-26 90.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDW53020.1 - 2.9e-08 34.1 0.0 1.1e-07 32.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDW53020.1 - 1.7e-07 31.2 0.1 0.0015 18.3 0.0 2.9 3 0 0 3 3 3 2 AAA domain ResIII PF04851.15 CDW53020.1 - 1.4e-05 25.1 0.0 3.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDW53020.1 - 0.00023 21.0 0.0 0.016 15.0 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 CDW53020.1 - 0.00039 20.0 0.0 0.00091 18.8 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 CDW53020.1 - 0.0008 19.8 0.0 0.0036 17.7 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 CDW53020.1 - 0.002 18.5 0.0 0.0052 17.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW53020.1 - 0.0021 18.3 0.0 0.011 16.0 0.0 2.3 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDW53020.1 - 0.0027 17.5 0.0 0.0055 16.5 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 CDW53020.1 - 0.026 13.8 0.3 0.052 12.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DnaB_C PF03796.15 CDW53020.1 - 0.033 13.5 0.0 0.065 12.5 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain RuvB_N PF05496.12 CDW53020.1 - 0.041 13.6 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Parvo_NS1 PF01057.17 CDW53020.1 - 0.061 12.4 0.1 0.15 11.1 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_5 PF07728.14 CDW53020.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 CDW53020.1 - 0.12 11.6 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 CDW53020.1 - 0.15 11.7 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDW53020.1 - 0.15 11.2 0.0 0.33 10.1 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Acetyltransf_18 PF18014.1 CDW53020.1 - 0.16 11.8 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Helicase_RecD PF05127.14 CDW53020.1 - 0.18 11.6 0.0 0.66 9.8 0.0 1.9 2 0 0 2 2 2 0 Helicase Ribosomal_S4e PF00900.20 CDW53021.1 - 4.3e-37 125.9 0.4 6e-36 122.2 0.0 2.6 3 0 0 3 3 3 1 Ribosomal family S4e 40S_S4_C PF16121.5 CDW53021.1 - 7.5e-23 79.9 0.0 1.2e-22 79.3 0.0 1.3 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 CDW53021.1 - 1.7e-21 76.0 4.4 3.9e-21 74.9 4.4 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 CDW53021.1 - 1.5e-06 27.8 0.0 3.1e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 CDW53021.1 - 8.2e-05 22.4 0.5 8.2e-05 22.4 0.5 2.3 3 0 0 3 3 3 1 KOW motif NTP_transferase PF00483.23 CDW53022.1 - 2e-51 175.0 0.0 3.2e-51 174.3 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 CDW53022.1 - 1.8e-10 41.4 0.0 2.4e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 CDW53022.1 - 4.5e-08 32.5 12.6 4.4e-05 23.0 1.6 3.6 1 1 2 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDW53022.1 - 0.021 14.6 1.1 0.021 14.6 1.1 3.1 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase CTP_transf_3 PF02348.19 CDW53022.1 - 0.21 11.5 0.0 0.34 10.8 0.0 1.2 1 0 0 1 1 1 0 Cytidylyltransferase EF-hand_1 PF00036.32 CDW53023.1 - 1.7e-35 117.9 13.7 1.4e-09 36.8 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDW53023.1 - 4.4e-29 100.7 7.8 3.1e-16 59.6 2.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW53023.1 - 4.4e-26 88.5 6.3 3.5e-08 32.8 0.2 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDW53023.1 - 8.4e-26 89.6 14.9 1.6e-13 50.3 1.2 4.0 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 CDW53023.1 - 3.2e-16 58.0 7.2 1.4e-06 27.5 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CDW53023.1 - 2.7e-13 50.0 0.3 2.4e-07 31.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CDW53023.1 - 1.2e-07 31.7 5.1 0.0015 18.4 0.3 3.2 1 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 CDW53023.1 - 5.9e-07 29.5 0.8 0.024 14.6 0.4 2.0 1 1 1 2 2 2 2 Tellurite resistance protein TerB p25-alpha PF05517.12 CDW53023.1 - 6.2e-05 23.2 1.9 0.055 13.6 0.1 2.2 1 1 1 2 2 2 2 p25-alpha SPARC_Ca_bdg PF10591.9 CDW53023.1 - 9.8e-05 22.7 0.8 0.021 15.2 0.1 2.1 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 CDW53023.1 - 0.00011 22.0 1.2 0.00011 22.0 1.2 2.3 2 0 0 2 2 2 1 EF hand Caleosin PF05042.13 CDW53023.1 - 0.00013 21.9 4.1 1.1 9.2 0.0 3.9 1 1 3 4 4 4 2 Caleosin related protein EFhand_Ca_insen PF08726.10 CDW53023.1 - 0.0083 16.2 1.2 0.026 14.6 0.4 2.1 2 0 0 2 2 2 1 Ca2+ insensitive EF hand UPF0154 PF03672.13 CDW53023.1 - 0.014 15.4 0.0 0.8 9.8 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) DNA_primase_lrg PF04104.14 CDW53023.1 - 0.04 13.3 0.1 0.053 12.9 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit DUF3349 PF11829.8 CDW53023.1 - 0.044 14.5 0.1 0.26 12.1 0.0 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) EF-hand_14 PF17959.1 CDW53023.1 - 0.069 13.5 1.5 2.4 8.6 0.3 2.4 1 1 1 2 2 2 0 EF-hand domain Phage_TAC_13 PF16459.5 CDW53023.1 - 0.076 13.5 0.1 0.34 11.4 0.1 2.1 1 1 0 1 1 1 0 Phage tail assembly chaperone, TAC RNB PF00773.19 CDW53023.1 - 0.087 12.1 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 RNB domain RTX_C PF08339.10 CDW53023.1 - 0.091 12.8 0.3 0.15 12.1 0.3 1.5 1 1 0 1 1 1 0 RTX C-terminal domain LPD25 PF18840.1 CDW53023.1 - 0.23 12.0 3.4 0.62 10.6 3.4 1.8 1 1 0 1 1 1 0 Large polyvalent protein associated domain 25 ARL2_Bind_BART PF11527.8 CDW53023.1 - 1.2 9.3 9.8 0.24 11.5 1.4 2.6 2 1 0 2 2 2 0 The ARF-like 2 binding protein BART RhoGEF PF00621.20 CDW53024.1 - 2e-19 70.6 3.4 3.2e-19 69.9 3.4 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 CDW53024.1 - 1.2e-16 61.1 0.4 8e-08 32.7 0.1 2.9 3 0 0 3 3 3 2 PH domain FYVE PF01363.21 CDW53024.1 - 2.3e-15 56.5 4.8 6e-15 55.1 4.8 1.7 1 0 0 1 1 1 1 FYVE zinc finger PH_11 PF15413.6 CDW53024.1 - 2.4e-14 53.6 0.7 5.3e-12 46.1 0.5 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_17 PF18012.1 CDW53024.1 - 1e-05 25.1 0.1 0.00037 20.1 0.1 2.6 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 CDW53024.1 - 0.0013 18.6 1.2 0.064 13.1 0.2 3.2 2 2 0 2 2 2 1 Pleckstrin homology domain PH_4 PF15404.6 CDW53024.1 - 0.0085 15.9 0.3 0.02 14.7 0.1 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain AMP-binding_C_2 PF14535.6 CDW53024.1 - 0.054 13.8 0.3 0.34 11.3 0.1 2.3 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain VIR_N PF15912.5 CDW53024.1 - 0.54 9.8 4.7 0.89 9.1 4.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal CHCH PF06747.13 CDW53026.1 - 3e-07 30.4 0.5 5.4e-07 29.6 0.5 1.4 1 0 0 1 1 1 1 CHCH domain DUF5424 PF17462.2 CDW53026.1 - 0.05 13.5 0.0 0.073 13.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5424) PGM_PMM_I PF02878.16 CDW53027.1 - 2.3e-38 131.0 0.1 3.6e-38 130.4 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDW53027.1 - 7e-26 90.7 0.0 1.7e-25 89.4 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDW53027.1 - 2.3e-12 47.4 0.0 7.3e-12 45.8 0.0 2.0 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDW53027.1 - 0.00028 21.0 0.0 0.00088 19.4 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain HLH PF00010.26 CDW53029.1 - 1e-14 54.2 0.0 2.8e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 CDW53029.1 - 0.0082 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain SPX PF03105.19 CDW53029.1 - 0.38 10.6 4.1 0.54 10.1 4.1 1.2 1 0 0 1 1 1 0 SPX domain SR-25 PF10500.9 CDW53029.1 - 0.61 9.7 13.4 0.65 9.6 2.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein UDPGP PF01704.18 CDW53031.1 - 4.4e-169 562.5 0.0 5e-169 562.3 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Nmad5 PF18757.1 CDW53032.1 - 0.05 13.8 0.2 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 DUF1772 PF08592.11 CDW53032.1 - 0.14 12.5 0.1 0.27 11.5 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) HpcH_HpaI PF03328.14 CDW53033.1 - 1.6e-49 168.0 0.0 2e-49 167.7 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 CDW53033.1 - 2.6e-12 46.6 0.0 3.1e-07 29.9 0.0 2.3 1 1 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold Cyclin_N PF00134.23 CDW53034.1 - 2.7e-13 49.8 0.6 2.7e-13 49.8 0.6 2.2 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 CDW53034.1 - 6.7e-07 29.6 0.5 2.4e-06 27.9 0.4 1.9 1 1 0 1 1 1 1 Cyclin C-terminal domain Cyclin_C PF02984.19 CDW53034.1 - 0.059 13.5 0.4 0.91 9.6 0.1 2.5 2 1 0 2 2 2 0 Cyclin, C-terminal domain DUF3381 PF11861.8 CDW53034.1 - 0.19 11.6 0.1 0.33 10.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF4735 PF15882.5 CDW53035.1 - 1.1e-14 54.5 0.6 5e-09 36.0 0.3 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4735) Kin17_mid PF10357.9 CDW53036.1 - 3.3e-48 162.8 2.5 8.1e-48 161.5 2.5 1.7 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 CDW53036.1 - 3.6e-16 59.0 0.9 4.8e-14 52.2 0.2 2.4 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain KOW PF00467.29 CDW53036.1 - 0.00048 20.0 3.2 0.095 12.7 0.1 3.2 3 0 0 3 3 3 2 KOW motif zf-C2H2_jaz PF12171.8 CDW53036.1 - 0.0015 18.7 8.8 0.0049 17.1 6.2 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW53036.1 - 0.0023 18.2 6.9 0.0058 17.0 6.9 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SspH PF08141.12 CDW53036.1 - 0.019 15.1 0.9 0.099 12.8 0.2 2.4 3 0 0 3 3 3 0 Small acid-soluble spore protein H family zf-C2H2_2 PF12756.7 CDW53036.1 - 0.071 13.5 5.2 0.084 13.2 1.6 2.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF3395 PF11875.8 CDW53036.1 - 3.3 7.6 10.9 9.8 6.0 5.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3395) Ras PF00071.22 CDW53038.1 - 6.8e-54 181.8 2.7 2.1e-53 180.3 2.7 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CDW53038.1 - 1.4e-31 109.2 0.2 2e-31 108.7 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW53038.1 - 3.1e-17 62.6 0.2 3.9e-17 62.2 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW53038.1 - 4.8e-06 26.1 0.1 6e-06 25.8 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 CDW53038.1 - 0.00039 20.2 3.1 0.024 14.4 3.1 2.7 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 CDW53038.1 - 0.001 18.6 0.1 0.0013 18.2 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 CDW53038.1 - 0.0032 17.3 0.3 0.065 13.0 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 CDW53038.1 - 0.0041 17.1 0.7 0.19 11.8 0.7 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 CDW53038.1 - 0.0059 16.7 0.1 0.012 15.7 0.1 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase TsaE PF02367.17 CDW53038.1 - 0.015 15.3 0.0 0.038 14.0 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Septin PF00735.18 CDW53038.1 - 0.016 14.5 0.3 0.57 9.4 0.1 2.2 2 0 0 2 2 2 0 Septin RsgA_GTPase PF03193.16 CDW53038.1 - 0.02 14.8 1.7 2.9 7.8 0.4 2.3 2 1 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 CDW53038.1 - 0.026 14.8 0.3 0.067 13.5 0.1 1.9 2 1 0 2 2 2 0 AAA domain IF3_N PF05198.16 CDW53038.1 - 0.04 14.2 0.1 0.1 12.9 0.1 1.6 1 1 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain AAA_18 PF13238.6 CDW53038.1 - 0.064 13.8 0.1 2.8 8.5 0.1 2.5 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 CDW53038.1 - 0.07 12.7 0.8 0.58 9.7 0.1 2.4 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 CDW53038.1 - 0.08 12.3 0.1 0.39 10.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 CDW53038.1 - 0.08 12.6 0.3 0.43 10.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDW53038.1 - 0.09 12.3 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 CDW53038.1 - 0.1 13.0 0.1 0.38 11.1 0.0 1.7 1 1 0 2 2 2 0 AAA ATPase domain CENP-X PF09415.10 CDW53039.1 - 1.5e-12 47.6 0.0 1.7e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 CDW53039.1 - 0.047 14.0 0.0 0.055 13.8 0.0 1.1 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SNAP PF14938.6 CDW53039.1 - 0.073 12.5 0.0 0.074 12.5 0.0 1.1 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP 7tm_1 PF00001.21 CDW53040.1 - 6.7e-50 169.8 18.8 9e-50 169.4 18.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW53040.1 - 4.3e-11 42.7 15.9 6e-11 42.2 15.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW53040.1 - 2.3e-09 37.3 24.7 7.1e-09 35.7 24.7 1.9 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 CDW53040.1 - 1.1e-05 25.4 6.6 1.1e-05 25.4 6.6 2.5 3 0 0 3 3 3 1 Olfactory receptor GPR_Gpa2_C PF11970.8 CDW53040.1 - 0.2 11.8 3.7 0.8 9.8 3.7 2.1 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term Piezo_RRas_bdg PF12166.8 CDW53040.1 - 2 7.6 5.1 7 5.8 0.1 2.5 2 1 1 3 3 3 0 Piezo non-specific cation channel, R-Ras-binding domain Adipogenin PF15202.6 CDW53040.1 - 9.9 6.3 9.1 0.44 10.6 0.2 3.1 3 0 0 3 3 3 0 Adipogenin Hyccin PF09790.9 CDW53041.1 - 1.3e-19 70.5 0.0 1.6e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Hyccin NTPase_I-T PF01931.18 CDW53041.1 - 0.064 13.0 0.0 9.6 6.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF84 Hyccin PF09790.9 CDW53042.1 - 8.9e-17 61.2 0.0 1.1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Hyccin GCV_T PF01571.21 CDW53043.1 - 1.8e-85 286.4 0.0 2.6e-85 285.9 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CDW53043.1 - 5.1e-16 58.4 0.1 1.2e-15 57.1 0.1 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 CDW53043.1 - 0.00057 20.0 0.0 0.014 15.6 0.0 2.2 1 1 1 2 2 2 1 Sarcosine oxidase, gamma subunit family DENN PF02141.21 CDW53044.1 - 4.5e-55 186.5 1.0 8.3e-55 185.6 1.0 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 CDW53044.1 - 7.4e-15 55.5 0.2 2e-14 54.1 0.2 1.8 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 CDW53044.1 - 7.4e-12 45.1 2.1 2e-11 43.7 2.1 1.8 1 0 0 1 1 1 1 dDENN domain PPR_2 PF13041.6 CDW53044.1 - 3.5e-05 23.9 0.0 8e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 PPR repeat family PPR_3 PF13812.6 CDW53044.1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 Pentatricopeptide repeat domain tRNA_int_end_N2 PF12928.7 CDW53045.1 - 0.00012 22.2 0.0 0.00029 21.0 0.0 1.6 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term RSS_P20 PF11757.8 CDW53046.1 - 0.0043 17.5 3.5 0.036 14.5 0.1 2.8 2 1 0 2 2 2 1 Suppressor of RNA silencing P21-like N-terminal domain Clusterin PF01093.17 CDW53046.1 - 0.0099 15.0 3.0 0.013 14.6 3.0 1.5 1 1 0 1 1 1 1 Clusterin Mis14 PF08641.12 CDW53046.1 - 0.045 14.1 0.5 0.045 14.1 0.5 2.4 2 1 0 2 2 2 0 Kinetochore protein Mis14 like AAA_32 PF13654.6 CDW53046.1 - 0.2 10.4 9.1 0.014 14.2 1.6 2.0 1 1 1 2 2 2 0 AAA domain EcoR124_C PF12008.8 CDW53046.1 - 1 9.0 9.6 19 4.8 9.6 2.2 1 1 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal TMPIT PF07851.13 CDW53046.1 - 1.1 8.4 5.5 0.23 10.7 0.7 1.9 2 0 0 2 2 2 0 TMPIT-like protein Prominin PF05478.11 CDW53046.1 - 1.2 7.0 7.0 2.9 5.7 7.0 1.6 1 1 0 1 1 1 0 Prominin gp32 PF08804.10 CDW53046.1 - 1.5 8.8 4.7 4.3 7.3 0.3 3.1 3 1 1 4 4 4 0 gp32 DNA binding protein like Mod_r PF07200.13 CDW53046.1 - 1.6 8.8 13.6 0.48 10.5 5.5 2.5 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CNOT11 PF10155.9 CDW53047.1 - 5.1e-17 62.2 1.4 8.1e-17 61.5 1.4 1.3 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 Nsp1_C PF05064.13 CDW53049.1 - 2.6e-19 69.1 10.6 2.6e-19 69.1 10.6 2.5 1 1 2 3 3 3 1 Nsp1-like C-terminal region DUF948 PF06103.11 CDW53049.1 - 0.0023 18.1 10.7 0.06 13.6 0.7 3.1 2 2 1 3 3 3 2 Bacterial protein of unknown function (DUF948) Bul1_C PF04426.12 CDW53049.1 - 0.019 14.4 10.9 0.04 13.3 10.9 1.6 1 1 0 1 1 1 0 Bul1 C terminus DLP_helical PF18709.1 CDW53049.1 - 0.057 12.6 10.5 0.071 12.3 10.5 1.2 1 0 0 1 1 1 0 Dynamin-like helical domain PI_PP_I PF18363.1 CDW53049.1 - 0.082 13.1 4.0 1.6 9.0 1.2 2.5 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain MCPsignal PF00015.21 CDW53049.1 - 0.084 12.7 8.5 0.066 13.0 0.7 2.3 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Synaptobrevin PF00957.21 CDW53049.1 - 0.086 12.6 13.6 0.97 9.3 1.7 3.9 2 2 2 4 4 4 0 Synaptobrevin LPP PF04728.13 CDW53049.1 - 0.12 12.8 10.9 2.7 8.4 0.0 4.1 3 1 1 4 4 4 0 Lipoprotein leucine-zipper Peptidase_S46 PF10459.9 CDW53049.1 - 0.18 10.4 8.5 0.21 10.2 8.5 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF3685 PF12452.8 CDW53049.1 - 0.41 10.3 8.6 0.6 9.8 6.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3685) DUF2937 PF11157.8 CDW53049.1 - 0.43 10.3 4.6 0.69 9.6 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) OGG_N PF07934.12 CDW53049.1 - 0.93 9.6 6.1 0.8 9.8 2.2 2.2 1 1 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain RVT_3 PF13456.6 CDW53049.1 - 1.1 9.1 4.3 0.74 9.6 0.3 2.5 1 1 2 3 3 3 0 Reverse transcriptase-like CREPT PF16566.5 CDW53049.1 - 1.1 9.4 14.8 0.16 12.1 4.5 2.5 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DUF3450 PF11932.8 CDW53049.1 - 1.2 8.4 22.0 1.7 7.9 18.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DivIC PF04977.15 CDW53049.1 - 1.5 8.6 15.1 0.72 9.7 2.3 3.5 2 1 1 3 3 3 0 Septum formation initiator HrpB2 PF09487.10 CDW53049.1 - 1.8 9.0 7.5 1 9.8 2.0 2.5 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB2) AAA_13 PF13166.6 CDW53049.1 - 2.2 6.8 14.5 0.35 9.4 4.3 2.0 1 1 1 2 2 2 0 AAA domain DUF883 PF05957.13 CDW53049.1 - 2.9 8.5 7.4 2.9 8.5 1.1 2.9 1 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF16 PF01519.16 CDW53049.1 - 3.7 8.1 20.8 9.2 6.8 8.3 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 XhlA PF10779.9 CDW53049.1 - 6.6 7.0 7.9 17 5.7 1.6 2.9 2 1 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 CDW53049.1 - 7.2 6.7 16.2 1.8 8.6 3.8 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) PMC2NT PF08066.12 CDW53049.1 - 7.4 7.3 8.8 36 5.1 6.7 3.0 2 1 0 2 2 2 0 PMC2NT (NUC016) domain FapA PF03961.13 CDW53049.1 - 7.7 5.0 13.9 4.3 5.8 2.2 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A FAM76 PF16046.5 CDW53049.1 - 9.8 5.4 14.9 1.7 8.0 3.9 2.2 1 1 1 2 2 2 0 FAM76 protein EF-hand_7 PF13499.6 CDW53050.1 - 1.9e-14 53.9 2.1 1.4e-07 31.8 0.1 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW53050.1 - 5.9e-12 44.5 2.8 5.6e-05 22.7 0.0 3.7 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 CDW53050.1 - 3.1e-10 38.8 2.6 0.00023 20.5 0.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 CDW53050.1 - 3e-09 36.6 1.7 0.00023 20.9 0.8 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CDW53050.1 - 7.8e-05 22.0 2.8 0.037 13.5 0.0 3.1 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 CDW53050.1 - 0.0034 17.7 0.1 0.017 15.5 0.1 1.9 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region PI-PLC-X PF00388.19 CDW53051.1 - 8.4e-59 197.3 0.0 2.3e-58 195.9 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CDW53051.1 - 4.8e-35 120.4 2.3 1.4e-32 112.4 0.1 3.4 2 1 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain RasGEF PF00617.19 CDW53051.1 - 1.7e-19 70.7 0.1 4.6e-19 69.3 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RA PF00788.23 CDW53051.1 - 2.1e-17 63.5 0.0 4.1e-08 33.8 0.0 3.0 2 1 0 2 2 2 2 Ras association (RalGDS/AF-6) domain C2 PF00168.30 CDW53051.1 - 9e-08 32.4 0.0 2.8e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 CDW53051.1 - 2.9e-07 30.9 0.1 2.9e-06 27.7 0.0 2.7 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like FERM_M PF00373.18 CDW53051.1 - 1.1e-06 29.0 1.4 3.6e-06 27.4 0.2 2.6 2 0 0 2 2 2 1 FERM central domain Ank_2 PF12796.7 CDW53051.1 - 0.00057 20.4 0.2 2.8 8.6 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) GDPD PF03009.17 CDW53051.1 - 0.047 13.4 0.0 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Ank_3 PF13606.6 CDW53051.1 - 0.11 13.1 1.0 1.1e+02 3.8 0.0 4.2 3 0 0 3 3 3 0 Ankyrin repeat Ank PF00023.30 CDW53051.1 - 0.31 11.6 1.4 5.6 7.6 0.0 3.5 3 0 0 3 3 3 0 Ankyrin repeat PBP1_TM PF14812.6 CDW53051.1 - 0.32 11.4 2.8 0.98 9.8 2.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ACC_central PF08326.12 CDW53052.1 - 6.5e-227 755.3 0.2 8.3e-227 755.0 0.2 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 CDW53052.1 - 3.1e-168 560.5 0.0 4.1e-168 560.0 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 CDW53052.1 - 4.1e-32 111.4 0.1 8.3e-16 58.1 0.0 2.9 2 1 1 3 3 3 2 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDW53052.1 - 9.6e-32 109.8 0.1 2.1e-31 108.7 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDW53052.1 - 4.1e-22 78.3 0.0 1.3e-21 76.7 0.0 2.0 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CDW53052.1 - 4.5e-14 52.0 0.0 1.2e-13 50.6 0.0 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme GxGYxYP_N PF16216.5 CDW53052.1 - 0.014 15.5 0.0 0.054 13.7 0.0 2.0 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal Dala_Dala_lig_C PF07478.13 CDW53052.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus CUE PF02845.16 CDW53053.1 - 6.1e-11 41.8 0.3 1.7e-10 40.4 0.1 1.8 2 0 0 2 2 2 1 CUE domain Peptidase_C50 PF03568.17 CDW53054.1 - 8.3e-66 222.7 0.4 8.5e-57 193.0 0.0 2.4 1 1 0 2 2 2 2 Peptidase family C50 Rogdi_lz PF10259.9 CDW53055.1 - 2.6e-14 53.3 0.0 3.6e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Hid1 PF12722.7 CDW53056.1 - 3e-253 842.7 0.8 2.2e-252 839.8 0.8 1.9 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 CDW53056.1 - 4.7e-225 748.8 0.0 5.4e-225 748.6 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Adeno_E3B PF03376.14 CDW53057.1 - 0.046 13.9 0.8 0.11 12.8 0.8 1.5 1 0 0 1 1 1 0 Adenovirus E3B protein PH PF00169.29 CDW53058.1 - 1.8e-08 34.8 0.0 2.7e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 PH domain zf-RING_2 PF13639.6 CDW53059.1 - 7.4e-15 55.0 15.1 8e-13 48.5 8.5 2.3 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 CDW53059.1 - 5e-13 48.7 14.7 3.6e-12 45.9 7.1 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDW53059.1 - 1.6e-10 40.5 2.6 1.6e-10 40.5 2.6 2.5 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 CDW53059.1 - 1.6e-10 40.6 9.7 4.3e-05 23.3 5.4 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_9 PF14369.6 CDW53059.1 - 6.5e-09 35.9 2.8 6.5e-09 35.9 2.8 2.8 3 0 0 3 3 3 1 zinc-ribbon zf-C3HC4 PF00097.25 CDW53059.1 - 2.6e-08 33.6 16.0 2.1e-07 30.7 5.7 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW53059.1 - 7.4e-08 32.2 15.1 9.1e-06 25.5 6.2 2.3 2 0 0 2 2 2 2 zinc-RING finger domain zf-rbx1 PF12678.7 CDW53059.1 - 2.1e-07 31.1 4.8 2.1e-07 31.1 4.8 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDW53059.1 - 1.6e-05 24.8 2.7 1.6e-05 24.8 2.7 3.1 2 2 2 4 4 4 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDW53059.1 - 6.1e-05 22.8 12.1 0.0024 17.7 6.2 2.4 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 DZR PF12773.7 CDW53059.1 - 0.00065 19.7 7.9 0.0064 16.5 0.5 2.3 2 0 0 2 2 2 1 Double zinc ribbon zf-ANAPC11 PF12861.7 CDW53059.1 - 0.0011 19.0 5.7 0.0013 18.7 2.5 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Vps39_2 PF10367.9 CDW53059.1 - 0.0026 18.2 2.8 0.69 10.4 0.0 3.1 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 HypA PF01155.19 CDW53059.1 - 0.0028 17.7 3.4 1.1 9.3 0.2 2.2 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA NOB1_Zn_bind PF08772.11 CDW53059.1 - 0.014 15.6 0.2 0.014 15.6 0.2 2.3 3 0 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like FYVE PF01363.21 CDW53059.1 - 0.017 15.2 3.4 3.3 7.9 0.0 3.0 3 0 0 3 3 3 0 FYVE zinc finger FANCL_C PF11793.8 CDW53059.1 - 0.022 14.9 7.1 0.16 12.2 4.6 3.0 2 1 0 2 2 2 0 FANCL C-terminal domain zinc_ribbon_15 PF17032.5 CDW53059.1 - 0.044 14.5 7.8 0.16 12.7 1.0 2.2 2 0 0 2 2 2 0 zinc-ribbon family zinc-ribbons_6 PF07191.12 CDW53059.1 - 0.088 12.8 8.9 0.22 11.5 0.2 3.0 2 1 1 3 3 3 0 zinc-ribbons zf-RING_10 PF16685.5 CDW53059.1 - 0.092 12.9 7.4 0.36 11.0 2.8 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 DUF5318 PF17249.2 CDW53059.1 - 0.11 12.2 1.2 6.5 6.5 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5318) Prok-RING_1 PF14446.6 CDW53059.1 - 0.15 12.0 11.0 1.6 8.7 0.6 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Stc1 PF12898.7 CDW53059.1 - 0.18 12.4 3.1 1 10.0 0.1 2.4 2 0 0 2 2 2 0 Stc1 domain zf-Di19 PF05605.12 CDW53059.1 - 0.31 11.4 8.8 2.2 8.7 0.8 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-ribbon_3 PF13248.6 CDW53059.1 - 0.52 9.8 0.0 0.52 9.8 0.0 3.3 4 0 0 4 4 4 0 zinc-ribbon domain zf-C2HC5 PF06221.13 CDW53059.1 - 0.94 9.5 4.4 6.9 6.8 0.1 2.9 3 0 0 3 3 3 0 Putative zinc finger motif, C2HC5-type zf-C2H2_4 PF13894.6 CDW53059.1 - 1.6 9.8 0.1 1.6 9.8 0.1 4.2 4 1 0 4 4 4 0 C2H2-type zinc finger Zf_RING PF16744.5 CDW53059.1 - 1.8 8.7 9.4 9.7 6.4 0.1 3.2 2 1 1 3 3 3 0 KIAA1045 RING finger zf-C2H2_jaz PF12171.8 CDW53059.1 - 2.5 8.5 7.3 32 5.0 0.9 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-RING_4 PF14570.6 CDW53059.1 - 3 7.7 14.8 2 8.3 4.7 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 CDW53059.1 - 5 6.8 10.9 0.75 9.5 4.6 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf_UBZ PF18439.1 CDW53059.1 - 5.8 6.6 11.9 1.6 8.3 0.1 3.7 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Collagen PF01391.18 CDW53060.1 - 2e-23 81.9 102.9 1.5e-09 37.5 26.8 5.0 4 1 0 4 4 4 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW53060.1 - 3.1e-20 71.9 0.4 4.1e-20 71.6 0.4 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain STAT_bind PF02864.15 CDW53062.1 - 1.9e-25 89.9 0.2 4e-25 88.9 0.2 1.6 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_alpha PF01017.20 CDW53062.1 - 1.1e-14 54.7 8.3 2e-14 53.9 8.3 1.3 1 0 0 1 1 1 1 STAT protein, all-alpha domain SH2 PF00017.24 CDW53062.1 - 7.6e-06 25.9 0.1 1.7e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 SH2 domain WGG PF10273.9 CDW53063.1 - 2.3e-15 57.0 0.0 3.2e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 CAF20 PF17052.5 CDW53063.1 - 0.021 15.0 0.0 0.029 14.5 0.0 1.3 1 0 0 1 1 1 0 Cap associated factor RRP7 PF12923.7 CDW53063.1 - 0.17 12.0 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain NDK PF00334.19 CDW53064.1 - 9.6e-55 184.3 0.0 1.1e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase GFRP PF06399.13 CDW53064.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) PSI_PsaJ PF01701.18 CDW53064.1 - 0.17 12.4 0.1 0.31 11.6 0.1 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ Ank_4 PF13637.6 CDW53065.1 - 6.1e-15 55.4 0.1 3.3e-08 33.9 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW53065.1 - 2.6e-12 47.1 0.1 2.1e-08 34.6 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW53065.1 - 1.9e-08 33.9 0.0 0.0021 18.4 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 CDW53065.1 - 3.7e-08 33.5 0.4 0.0018 18.6 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 CDW53065.1 - 1.7e-05 25.0 0.2 0.028 14.8 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) UPF0029 PF01205.19 CDW53067.1 - 7.9e-35 119.4 0.1 2.2e-34 117.9 0.1 1.7 2 0 0 2 2 2 1 Uncharacterized protein family UPF0029 RWD PF05773.22 CDW53067.1 - 4.5e-13 49.5 1.4 9.1e-13 48.5 1.4 1.5 1 0 0 1 1 1 1 RWD domain Imm50 PF15594.6 CDW53067.1 - 0.019 15.2 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 50 DUF3455 PF11937.8 CDW53067.1 - 0.12 12.7 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3455) PliI PF16743.5 CDW53067.1 - 0.17 11.7 0.1 0.68 9.7 0.0 1.9 2 0 0 2 2 2 0 Periplasmic lysozyme inhibitor of I-type lysozyme VPS13_C PF16909.5 CDW53068.1 - 1.5e-06 28.1 0.0 2.8e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 CDW53068.1 - 3.2e-06 27.4 0.0 9.6e-06 25.9 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain ATG2_CAD PF13329.6 CDW53068.1 - 0.0074 16.0 0.1 0.019 14.7 0.1 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif UPF0565 PF10561.9 CDW53069.1 - 1e-67 228.5 9.3 4.8e-34 117.9 0.5 3.9 3 1 1 4 4 4 3 Uncharacterised protein family UPF0565 ELYS-bb PF16687.5 CDW53069.1 - 4.1e-07 29.0 4.1 5.8e-05 21.9 4.1 3.0 1 1 0 1 1 1 1 beta-propeller of ELYS nucleoporin ELYS PF13934.6 CDW53069.1 - 0.00037 20.6 0.3 0.00098 19.2 0.3 1.6 1 0 0 1 1 1 1 Nuclear pore complex assembly Dus PF01207.17 CDW53070.1 - 1.4e-60 205.0 0.0 2e-60 204.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) GpcrRhopsn4 PF10192.9 CDW53070.1 - 1e-37 130.0 12.9 1.5e-37 129.4 12.9 1.3 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain His_biosynth PF00977.21 CDW53070.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein Med12-LCEWAV PF12145.8 CDW53071.1 - 3.5e-86 290.0 3.3 3.5e-86 290.0 3.3 4.0 2 1 1 3 3 3 1 Eukaryotic Mediator 12 subunit domain Med12 PF09497.10 CDW53071.1 - 7.2e-10 39.0 0.2 1.9e-09 37.7 0.2 1.8 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 DUF5345 PF17280.2 CDW53071.1 - 0.17 11.8 1.0 0.55 10.3 1.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5345) LSM PF01423.22 CDW53072.1 - 8.5e-15 54.2 0.1 1.1e-14 53.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CDW53072.1 - 0.0029 17.2 0.0 0.0043 16.7 0.0 1.3 1 0 0 1 1 1 1 Hfq protein UQ_con PF00179.26 CDW53075.1 - 5.2e-37 126.6 0.0 2.4e-33 114.8 0.0 2.0 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDW53075.1 - 0.0012 18.5 0.0 0.0018 18.0 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B UFC1 PF08694.11 CDW53075.1 - 0.03 14.0 0.0 0.046 13.3 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 CDW53075.1 - 0.068 13.5 0.0 0.068 13.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain TB2_DP1_HVA22 PF03134.19 CDW53076.1 - 3.8e-08 33.1 3.9 7.8e-08 32.1 3.9 1.6 1 0 0 1 1 1 1 TB2/DP1, HVA22 family GET2 PF08690.10 CDW53076.1 - 7.2 6.2 19.1 0.17 11.5 11.3 2.3 2 1 1 3 3 3 0 GET complex subunit GET2 ATP-synt_Eps PF04627.13 CDW53077.1 - 3.8e-23 81.2 0.1 4.4e-23 81.0 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Kinesin PF00225.23 CDW53078.1 - 1.7e-110 369.1 3.9 2.3e-110 368.7 0.0 2.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CDW53078.1 - 8e-27 94.0 0.2 4.3e-26 91.6 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding APG6_N PF17675.1 CDW53078.1 - 0.0013 19.3 11.5 0.0013 19.3 11.5 6.0 4 2 1 5 5 5 2 Apg6 coiled-coil region KASH_CCD PF14662.6 CDW53078.1 - 0.0018 18.1 21.4 0.0018 18.1 21.4 4.3 4 1 0 4 4 4 1 Coiled-coil region of CCDC155 or KASH SHE3 PF17078.5 CDW53078.1 - 0.01 15.6 4.5 0.01 15.6 4.5 5.4 4 3 1 5 5 5 0 SWI5-dependent HO expression protein 3 MMADHC PF10229.9 CDW53079.1 - 1.4e-47 162.7 0.0 2.3e-46 158.8 0.0 2.0 1 1 1 2 2 2 2 Methylmalonic aciduria and homocystinuria type D protein HPD PF05044.12 CDW53080.1 - 4.8e-78 260.4 4.1 5.1e-78 260.3 2.8 1.7 2 0 0 2 2 2 1 Homeo-prospero domain NOA36 PF06524.12 CDW53080.1 - 0.15 11.4 16.6 0.29 10.4 16.6 1.4 1 0 0 1 1 1 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 CDW53080.1 - 0.36 11.0 19.6 1 9.6 19.6 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PAP_PilO PF06864.12 CDW53080.1 - 0.73 8.6 3.1 8.5 5.1 0.0 2.3 2 0 0 2 2 2 0 Pilin accessory protein (PilO) DNA_pol_phi PF04931.13 CDW53080.1 - 1.9 6.5 15.7 2.8 5.9 15.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Gelsolin PF00626.22 CDW53081.1 - 9.5e-59 195.3 5.3 7.1e-15 54.7 0.0 7.0 7 0 0 7 7 7 6 Gelsolin repeat LRR_8 PF13855.6 CDW53081.1 - 4.5e-37 125.6 39.5 3.1e-09 36.5 2.1 7.1 6 1 1 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 CDW53081.1 - 6.3e-22 77.3 55.9 0.00014 22.1 0.9 8.9 6 3 2 10 10 10 7 Leucine Rich repeats (2 copies) Cofilin_ADF PF00241.20 CDW53081.1 - 0.015 15.0 0.0 0.06 13.1 0.0 2.0 1 0 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein Rtt106 PF08512.12 CDW53081.1 - 0.16 12.4 0.1 1.8 9.0 0.2 2.5 2 0 0 2 2 2 0 Histone chaperone Rttp106-like LRR_1 PF00560.33 CDW53081.1 - 4.5 8.2 42.6 4.4 8.2 0.1 11.8 14 0 0 14 14 14 0 Leucine Rich Repeat DUF3180 PF11377.8 CDW53082.1 - 0.33 11.1 7.5 3.4 7.8 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) WD40 PF00400.32 CDW53083.1 - 1.6e-09 38.2 11.3 1.3 10.0 0.0 7.1 6 1 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53083.1 - 1.4e-06 28.5 0.0 0.055 13.8 0.0 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW53083.1 - 0.084 11.8 0.0 0.3 10.0 0.0 1.8 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein YbgS PF13985.6 CDW53084.1 - 0.0015 18.8 14.7 0.2 11.9 0.2 4.4 4 0 0 4 4 4 3 YbgS-like protein COX4 PF02936.14 CDW53084.1 - 0.0023 18.0 2.9 0.12 12.4 0.1 2.7 2 0 0 2 2 2 2 Cytochrome c oxidase subunit IV RVT_N PF13655.6 CDW53084.1 - 0.036 14.3 0.2 0.33 11.2 0.0 2.8 2 0 0 2 2 2 0 N-terminal domain of reverse transcriptase Get5_bdg PF16843.5 CDW53084.1 - 0.05 13.1 0.7 15 5.1 0.0 4.0 4 0 0 4 4 4 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein RasGEF PF00617.19 CDW53084.1 - 1.9 8.6 6.1 11 6.1 0.1 3.5 1 1 0 2 2 2 0 RasGEF domain Nif11 PF07862.11 CDW53084.1 - 3.4 8.0 7.0 1.2 9.5 0.0 3.9 3 1 0 3 3 3 0 Nif11 domain Methyltransf_11 PF08241.12 CDW53085.1 - 8.5e-18 64.8 0.0 1.6e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW53085.1 - 9.8e-16 58.2 0.0 2e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain 2OG-FeII_Oxy_2 PF13532.6 CDW53085.1 - 9.4e-13 48.8 0.0 2.8e-12 47.2 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltransf_31 PF13847.6 CDW53085.1 - 1.5e-09 37.8 0.0 3.2e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW53085.1 - 9.7e-09 35.9 0.0 2e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW53085.1 - 5.3e-07 29.6 0.0 1.5e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDW53085.1 - 5.4e-06 25.9 0.0 1.3e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 CDW53085.1 - 2.3e-05 24.4 0.0 3.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.12 CDW53085.1 - 0.00013 21.6 0.1 0.00022 20.9 0.1 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 CDW53085.1 - 0.0013 17.7 0.0 0.0033 16.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 CDW53085.1 - 0.0029 17.0 0.0 0.0053 16.1 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase RRM_1 PF00076.22 CDW53085.1 - 0.015 15.1 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3591 PF12157.8 CDW53086.1 - 2.4e-130 435.2 0.0 1.1e-129 432.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 CDW53086.1 - 6.1e-39 132.0 0.7 3e-18 65.6 0.2 2.7 2 0 0 2 2 2 2 Bromodomain zf-CCHC_6 PF15288.6 CDW53086.1 - 3.2e-07 30.1 0.1 1e-06 28.5 0.1 1.9 1 0 0 1 1 1 1 Zinc knuckle DUF2267 PF10025.9 CDW53086.1 - 0.05 13.9 0.1 0.88 9.9 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2267) FtsX_ECD PF18075.1 CDW53086.1 - 0.061 14.0 3.7 0.56 10.9 0.7 2.9 2 0 0 2 2 2 0 FtsX extracellular domain Ribosomal_L44 PF00935.19 CDW53086.1 - 0.13 12.8 3.8 0.45 11.0 3.8 2.0 1 0 0 1 1 1 0 Ribosomal protein L44 Methyltr_RsmB-F PF01189.17 CDW53087.1 - 5.9e-71 238.2 0.0 8.4e-71 237.8 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 CDW53087.1 - 1.6e-09 38.1 0.0 4.2e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 CDW53087.1 - 9.9e-05 22.5 0.0 0.00019 21.6 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Met_10 PF02475.16 CDW53087.1 - 0.00013 21.8 0.0 0.00024 20.9 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein DUF938 PF06080.12 CDW53087.1 - 0.0071 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) PCMT PF01135.19 CDW53087.1 - 0.042 13.6 0.0 0.071 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TMEM223 PF14640.6 CDW53088.1 - 0.098 12.8 0.1 0.12 12.5 0.1 1.4 1 1 0 1 1 1 0 Transmembrane protein 223 NIF PF03031.18 CDW53089.1 - 1.3e-48 164.7 0.2 1.6e-48 164.4 0.2 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Noc2 PF03715.13 CDW53089.1 - 0.022 14.0 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Noc2p family MatP_C PF17414.2 CDW53090.1 - 0.0089 16.2 1.6 0.44 10.8 0.1 2.6 2 0 0 2 2 2 1 MatP C-terminal ribbon-helix-helix domain ABC1 PF03109.16 CDW53090.1 - 0.11 12.6 0.1 0.25 11.5 0.1 1.5 1 0 0 1 1 1 0 ABC1 family BCAS3 PF12490.8 CDW53090.1 - 0.25 10.8 0.8 0.32 10.5 0.8 1.1 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 Peptidase_M13_N PF05649.13 CDW53091.1 - 5.2e-05 23.1 8.9 0.028 14.1 2.4 2.4 1 1 0 2 2 2 2 Peptidase family M13 LOH1CR12 PF10158.9 CDW53091.1 - 0.0051 16.8 1.0 0.0051 16.8 1.0 2.9 2 1 2 4 4 4 1 Tumour suppressor protein DUF5352 PF17303.2 CDW53091.1 - 0.042 13.7 0.5 0.042 13.7 0.5 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5352) COX4 PF02936.14 CDW53091.1 - 0.11 12.5 3.1 0.16 12.0 1.1 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV Ogr_Delta PF04606.12 CDW53091.1 - 1.2 9.2 6.7 14 5.7 0.0 3.7 4 0 0 4 4 4 0 Ogr/Delta-like zinc finger COX4 PF02936.14 CDW53092.1 - 0.039 14.0 13.2 0.28 11.2 1.3 3.9 3 1 0 3 3 3 0 Cytochrome c oxidase subunit IV KNOX2 PF03791.13 CDW53092.1 - 0.43 10.1 11.6 1.2 8.7 0.3 4.4 4 0 0 4 4 4 0 KNOX2 domain zf-RING-like PF08746.11 CDW53092.1 - 0.59 10.5 5.1 0.37 11.1 0.4 2.4 2 0 0 2 2 2 0 RING-like domain FTCD_C PF04961.12 CDW53092.1 - 0.97 9.2 5.4 0.29 10.9 1.6 2.0 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase COX15-CtaA PF02628.15 CDW53093.1 - 3e-83 279.6 10.0 3.4e-83 279.4 10.0 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF1201 PF06716.11 CDW53093.1 - 0.069 13.2 0.9 8.9 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) WD40 PF00400.32 CDW53095.1 - 2.3e-27 94.7 9.9 2.1e-05 25.2 0.0 8.1 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53095.1 - 1.6e-12 47.5 0.0 0.0081 16.4 0.0 4.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW53095.1 - 0.082 12.2 0.0 0.81 9.0 0.0 2.1 1 1 0 2 2 2 0 WD40-like domain Rotamase PF00639.21 CDW53096.1 - 2.8e-25 89.1 0.0 3.9e-25 88.6 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CDW53096.1 - 7.2e-22 78.1 0.0 9.5e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 CDW53096.1 - 2.1e-10 40.5 3.1 2.1e-10 40.5 3.1 1.8 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 CDW53096.1 - 8.4e-06 26.6 0.0 1.7e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 PPIC-type PPIASE domain MBD PF01429.19 CDW53096.1 - 0.01 15.5 0.2 0.058 13.1 0.0 2.1 2 0 0 2 2 2 0 Methyl-CpG binding domain SMC_hinge PF06470.13 CDW53096.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain Band_7 PF01145.25 CDW53098.1 - 2.4e-09 37.4 0.5 3.6e-09 36.9 0.5 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family MFS_1 PF07690.16 CDW53099.1 - 1.6e-18 66.8 32.3 5.2e-18 65.1 22.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily FYVE PF01363.21 CDW53100.1 - 4.2e-21 74.9 9.9 8.8e-21 73.8 9.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger RUN PF02759.19 CDW53100.1 - 1.2e-17 64.2 0.4 1.2e-17 64.2 0.4 2.7 2 1 0 2 2 2 1 RUN domain CCDC144C PF14915.6 CDW53100.1 - 4.9e-05 22.6 31.5 4.9e-05 22.6 31.5 2.4 1 1 0 2 2 2 1 CCDC144C protein coiled-coil region ATG16 PF08614.11 CDW53100.1 - 0.00089 19.5 39.0 0.07 13.3 20.1 2.3 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Tropomyosin PF00261.20 CDW53100.1 - 0.023 14.1 38.9 0.012 14.9 7.0 2.2 1 1 1 2 2 2 0 Tropomyosin IBR PF01485.21 CDW53100.1 - 0.025 14.8 7.2 0.077 13.2 7.2 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain CASP_C PF08172.12 CDW53100.1 - 0.027 13.8 26.9 0.1 11.9 5.0 3.6 1 1 3 4 4 4 0 CASP C terminal MscS_porin PF12795.7 CDW53100.1 - 0.035 13.6 36.0 0.091 12.3 11.0 2.6 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Sec34 PF04136.15 CDW53100.1 - 0.1 12.4 17.2 0.37 10.7 2.8 3.6 2 1 1 3 3 3 0 Sec34-like family DUF148 PF02520.17 CDW53100.1 - 0.31 11.2 15.2 0.14 12.3 1.3 4.1 4 0 0 4 4 4 0 Domain of unknown function DUF148 Spc7 PF08317.11 CDW53100.1 - 0.41 9.5 36.7 1 8.2 19.9 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein DASH_Duo1 PF08651.10 CDW53100.1 - 0.77 9.6 9.8 2.7 7.8 0.8 3.3 2 1 1 3 3 2 0 DASH complex subunit Duo1 V_ATPase_I PF01496.19 CDW53100.1 - 1.1 7.1 23.3 0.2 9.6 15.0 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family VPS11_C PF12451.8 CDW53100.1 - 1.2 9.4 4.4 14 6.0 0.5 3.3 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal Tropomyosin_1 PF12718.7 CDW53100.1 - 1.2 9.3 40.9 0.19 11.8 9.3 3.1 1 1 1 2 2 2 0 Tropomyosin like AAA_13 PF13166.6 CDW53100.1 - 1.4 7.5 28.2 0.0098 14.6 14.2 2.3 1 1 1 2 2 2 0 AAA domain LMBR1 PF04791.16 CDW53100.1 - 1.5 7.7 12.3 2.4 7.0 12.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein NPV_P10 PF05531.12 CDW53100.1 - 2.1 8.8 12.0 12 6.4 0.3 4.2 3 1 2 5 5 4 0 Nucleopolyhedrovirus P10 protein Macoilin PF09726.9 CDW53100.1 - 2.4 6.6 30.6 0.15 10.6 8.7 2.2 1 1 1 2 2 2 0 Macoilin family DUF2203 PF09969.9 CDW53100.1 - 2.8 8.7 22.5 0.51 11.1 2.6 3.9 2 1 2 4 4 3 0 Uncharacterized conserved protein (DUF2203) DHR10 PF18595.1 CDW53100.1 - 3.6 7.7 41.2 1.7 8.8 5.6 4.8 2 1 2 5 5 5 0 Designed helical repeat protein 10 domain Mt_ATP-synt_D PF05873.12 CDW53100.1 - 4.1 7.2 12.2 0.38 10.6 1.5 3.4 3 1 1 4 4 3 0 ATP synthase D chain, mitochondrial (ATP5H) DUF641 PF04859.12 CDW53100.1 - 5.1 7.4 27.7 0.067 13.5 2.1 4.2 2 2 1 3 3 2 0 Plant protein of unknown function (DUF641) TMCO5 PF14992.6 CDW53100.1 - 5.8 6.4 27.3 4.6 6.7 5.2 2.3 1 1 0 2 2 2 0 TMCO5 family TPR_MLP1_2 PF07926.12 CDW53100.1 - 6.9 6.7 36.2 8.2 6.5 10.1 4.3 3 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein zf-RING_2 PF13639.6 CDW53100.1 - 7.6 7.0 11.4 18 5.8 11.4 1.7 1 0 0 1 1 1 0 Ring finger domain ZapB PF06005.12 CDW53100.1 - 7.8 7.0 43.1 0.11 13.0 3.7 4.6 2 1 2 4 4 4 0 Cell division protein ZapB Seryl_tRNA_N PF02403.22 CDW53100.1 - 8.3 6.7 26.9 1.3 9.3 5.6 3.7 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain HAP1_N PF04849.13 CDW53100.1 - 8.8 5.4 37.9 13 4.9 20.0 3.6 1 1 0 2 2 2 0 HAP1 N-terminal conserved region TB2_DP1_HVA22 PF03134.19 CDW53101.1 - 9.5e-26 89.6 7.3 9.5e-26 89.6 7.3 1.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family BRI3BP PF14965.6 CDW53101.1 - 0.7 9.4 4.1 2.1 7.8 4.0 1.7 1 1 0 1 1 1 0 Negative regulator of p53/TP53 MLANA PF14991.6 CDW53102.1 - 0.16 12.3 0.2 0.22 11.8 0.2 1.3 1 0 0 1 1 1 0 Protein melan-A B-block_TFIIIC PF04182.12 CDW53103.1 - 3.2e-08 33.6 0.2 0.0011 19.0 0.0 3.4 3 0 0 3 3 3 2 B-block binding subunit of TFIIIC MarR_2 PF12802.7 CDW53103.1 - 4.3e-06 26.5 0.7 0.023 14.6 0.0 3.7 4 0 0 4 4 4 2 MarR family HTH_24 PF13412.6 CDW53103.1 - 0.001 18.5 0.1 0.0044 16.6 0.1 2.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding RNA_pol_Rpc34 PF05158.12 CDW53103.1 - 0.0023 17.4 0.1 0.0066 15.9 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit MarR PF01047.22 CDW53103.1 - 0.046 13.6 0.0 0.24 11.4 0.0 2.3 1 0 0 1 1 1 0 MarR family Tim17 PF02466.19 CDW53104.1 - 7.3e-10 39.2 3.1 1.1e-09 38.7 3.1 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family NUDIX PF00293.28 CDW53105.1 - 2.8e-10 40.3 0.0 8.4e-08 32.3 0.0 2.8 2 0 0 2 2 2 1 NUDIX domain zf-RING_UBOX PF13445.6 CDW53105.1 - 1.1e-07 31.7 3.9 1.1e-07 31.7 3.9 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDW53105.1 - 7.1e-06 25.9 2.5 7.1e-06 25.9 2.5 2.9 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDW53105.1 - 4.8e-05 23.1 3.2 4.8e-05 23.1 3.2 2.8 2 1 2 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-NADH-PPase PF09297.11 CDW53105.1 - 0.00027 20.5 0.5 0.00027 20.5 0.5 2.0 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain zf-C3HC4_2 PF13923.6 CDW53105.1 - 0.00032 20.5 4.1 0.00032 20.5 4.1 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW53105.1 - 0.0023 18.2 7.0 0.0023 18.2 7.0 3.0 3 1 1 4 4 4 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDW53105.1 - 0.0024 17.7 15.4 0.0076 16.1 6.0 2.9 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDW53105.1 - 0.39 10.9 15.3 0.52 10.5 5.8 3.1 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING DZR PF12773.7 CDW53105.1 - 4.2 7.5 11.1 0.11 12.6 0.8 2.7 2 0 0 2 2 2 0 Double zinc ribbon Snf7 PF03357.21 CDW53106.1 - 2.1e-24 86.0 6.8 2.5e-24 85.8 6.8 1.1 1 0 0 1 1 1 1 Snf7 Bax1-I PF01027.20 CDW53107.1 - 2.6e-34 118.9 15.7 9e-24 84.5 3.6 2.2 2 0 0 2 2 2 2 Inhibitor of apoptosis-promoting Bax1 Malate_synthase PF01274.22 CDW53109.1 - 6.5e-196 651.6 0.0 8.8e-196 651.2 0.0 1.1 1 0 0 1 1 1 1 Malate synthase ICL PF00463.21 CDW53109.1 - 5.8e-98 328.7 0.1 3.8e-51 174.2 0.0 2.2 1 1 1 2 2 2 2 Isocitrate lyase family PEP_mutase PF13714.6 CDW53109.1 - 9e-12 45.0 0.0 1.8e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase S-methyl_trans PF02574.16 CDW53109.1 - 0.014 15.3 0.0 6.5 6.5 0.0 2.9 2 1 0 2 2 2 0 Homocysteine S-methyltransferase CBM_21 PF03370.13 CDW53111.1 - 1.3e-31 109.0 2.9 1.3e-31 109.0 2.9 1.5 2 0 0 2 2 2 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 CDW53111.1 - 7.8e-12 45.6 0.4 1.7e-11 44.6 0.4 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) DUF928 PF06051.12 CDW53111.1 - 0.096 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) PRAS PF15798.5 CDW53112.1 - 1.9e-05 25.3 0.5 4.8e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Proline-rich AKT1 substrate 1 MRP-L28 PF09812.9 CDW53113.1 - 2.6e-34 118.7 7.3 3.4e-34 118.3 7.3 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 WD40 PF00400.32 CDW53113.1 - 2.2e-09 37.8 3.4 0.012 16.5 0.0 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53113.1 - 0.00018 21.7 0.0 0.031 14.6 0.0 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW53113.1 - 0.036 13.0 0.1 1.4 7.9 0.0 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Forkhead PF00250.18 CDW53114.1 - 4.7e-34 116.5 0.1 9e-34 115.6 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain Sod_Cu PF00080.20 CDW53115.1 - 3e-43 147.4 3.3 3.4e-43 147.2 3.3 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) FANCD2OS PF15124.6 CDW53115.1 - 0.25 11.6 0.0 0.28 11.4 0.0 1.1 1 0 0 1 1 1 0 FANCD2 opposite strand protein EGF PF00008.27 CDW53116.1 - 2.9e-47 158.5 140.6 1.8e-06 28.1 6.5 10.7 10 0 0 10 10 10 10 EGF-like domain EGF_CA PF07645.15 CDW53116.1 - 3.4e-38 129.6 148.5 8.9e-09 35.4 9.7 10.5 8 1 2 10 10 10 7 Calcium-binding EGF domain hEGF PF12661.7 CDW53116.1 - 7.9e-20 70.7 140.8 7.5e-06 26.4 5.8 12.7 13 0 0 13 13 13 7 Human growth factor-like EGF EGF_2 PF07974.13 CDW53116.1 - 2.4e-15 56.6 173.7 0.00024 21.4 9.1 10.9 11 0 0 11 11 11 8 EGF-like domain EGF_3 PF12947.7 CDW53116.1 - 7.8e-15 54.8 128.2 0.0095 16.1 5.1 11.1 8 3 2 10 10 10 8 EGF domain FXa_inhibition PF14670.6 CDW53116.1 - 0.00016 21.9 121.7 0.14 12.4 6.2 10.8 3 2 7 10 10 10 6 Coagulation Factor Xa inhibitory site Longin PF13774.6 CDW53117.1 - 1.4e-24 85.9 0.1 2.5e-24 85.1 0.1 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 CDW53117.1 - 8.2e-15 54.4 0.7 1.3e-14 53.8 0.7 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF4505 PF14956.6 CDW53119.1 - 2.5e-60 203.3 0.5 4.2e-59 199.3 0.5 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4505) KH_1 PF00013.29 CDW53120.1 - 7.3e-07 28.9 0.0 1.4e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 KH domain Qua1 PF16274.5 CDW53120.1 - 0.013 15.3 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 Qua1 domain TPX2 PF06886.11 CDW53121.1 - 3.9e-11 43.0 16.0 3.9e-11 43.0 16.0 3.0 3 1 0 3 3 3 1 Targeting protein for Xklp2 (TPX2) DUF2397 PF09660.10 CDW53121.1 - 0.27 10.1 14.6 0.036 13.0 10.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2397) AAA_23 PF13476.6 CDW53121.1 - 0.56 10.7 14.1 0.99 9.9 14.1 1.4 1 1 0 1 1 1 0 AAA domain BcrAD_BadFG PF01869.20 CDW53122.1 - 1e-18 67.8 0.0 1.3e-18 67.4 0.0 1.2 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family DUF2294 PF10057.9 CDW53122.1 - 0.23 11.6 0.0 0.4 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) Trypsin PF00089.26 CDW53123.1 - 7.3e-55 186.2 1.2 9e-55 185.9 1.2 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 CDW53123.1 - 0.0038 17.6 0.3 0.0067 16.8 0.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Peptidase_C3 PF00548.20 CDW53123.1 - 0.091 12.7 3.6 0.81 9.6 0.1 2.9 3 0 0 3 3 3 0 3C cysteine protease (picornain 3C) Sec7 PF01369.20 CDW53124.1 - 1.3e-70 236.8 0.1 1.7e-70 236.4 0.1 1.1 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 CDW53124.1 - 8.4e-26 90.5 0.1 1.4e-25 89.8 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CDW53124.1 - 1.2e-09 38.5 0.2 2.6e-09 37.4 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 CDW53124.1 - 0.0021 18.3 0.1 0.051 13.9 0.0 2.4 1 1 1 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 CDW53124.1 - 0.087 13.1 0.0 7.1 7.0 0.1 2.7 2 1 1 3 3 3 0 Pleckstrin homology domain PH_3 PF14593.6 CDW53124.1 - 0.088 12.9 0.0 0.27 11.4 0.0 1.8 1 0 0 1 1 1 0 PH domain Tubulin PF00091.25 CDW53125.1 - 3.4e-61 206.9 0.0 4.7e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDW53125.1 - 3e-42 143.8 0.0 5e-42 143.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDW53125.1 - 0.005 16.5 0.0 0.0097 15.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain WAC_Acf1_DNA_bd PF10537.9 CDW53126.1 - 1.4e-26 92.9 0.7 2.8e-25 88.7 0.0 3.4 3 0 0 3 3 3 1 ATP-utilising chromatin assembly and remodelling N-terminal Bromodomain PF00439.25 CDW53126.1 - 2.3e-19 69.3 0.0 5e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 CDW53126.1 - 1.5e-15 56.8 21.7 3.1e-09 36.6 5.7 2.8 2 0 0 2 2 2 2 PHD-finger WSD PF15613.6 CDW53126.1 - 5e-11 42.9 0.0 5e-11 42.9 0.0 2.9 4 0 0 4 4 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 CDW53126.1 - 8e-08 32.5 1.7 2.3e-07 31.0 1.7 1.9 1 0 0 1 1 1 1 DDT domain PHD_2 PF13831.6 CDW53126.1 - 1.6e-07 30.8 12.4 2.8e-05 23.6 5.3 3.2 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H PF13771.6 CDW53126.1 - 0.00091 19.4 13.6 0.041 14.1 1.4 2.8 2 0 0 2 2 2 2 PHD-like zinc-binding domain Zf_RING PF16744.5 CDW53126.1 - 0.0096 16.0 15.9 0.25 11.5 3.9 2.8 2 0 0 2 2 2 2 KIAA1045 RING finger Prok-RING_1 PF14446.6 CDW53126.1 - 0.017 15.0 13.1 0.95 9.4 5.7 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_2 PF03107.16 CDW53126.1 - 0.022 15.1 14.5 0.21 11.9 3.0 3.1 2 0 0 2 2 2 0 C1 domain ACCA PF03255.14 CDW53126.1 - 0.031 14.2 0.0 0.031 14.2 0.0 2.2 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit zf-HC5HC2H_2 PF13832.6 CDW53126.1 - 0.14 12.3 17.0 0.45 10.7 4.6 2.7 2 0 0 2 2 2 0 PHD-zinc-finger like domain zinc_ribbon_15 PF17032.5 CDW53126.1 - 1.9 9.3 15.3 6.3 7.6 4.7 3.5 3 0 0 3 3 3 0 zinc-ribbon family zf-RING_2 PF13639.6 CDW53126.1 - 2.4 8.6 23.3 0.36 11.2 7.8 2.9 2 0 0 2 2 2 0 Ring finger domain WBP-1 PF11669.8 CDW53127.1 - 0.00027 21.5 1.5 0.00042 20.9 1.5 1.3 1 0 0 1 1 1 1 WW domain-binding protein 1 PRIMA1 PF16101.5 CDW53127.1 - 0.0014 18.6 0.1 0.0023 17.9 0.1 1.3 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 EphA2_TM PF14575.6 CDW53127.1 - 0.0081 17.0 0.2 0.017 16.0 0.0 1.6 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 CDW53127.1 - 0.0089 16.3 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 7TM_GPCR_Srx PF10328.9 CDW53127.1 - 0.023 14.3 0.1 0.029 14.0 0.1 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx Sigma_reg_N PF13800.6 CDW53127.1 - 0.026 14.8 0.0 0.04 14.2 0.0 1.2 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF3169 PF11368.8 CDW53127.1 - 0.034 13.7 0.0 0.043 13.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) Baculo_11_kDa PF06143.11 CDW53127.1 - 0.047 13.3 0.0 0.073 12.6 0.0 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family TMEM132D_C PF15706.5 CDW53127.1 - 0.078 12.8 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF2681 PF10883.8 CDW53127.1 - 0.082 13.3 0.2 0.12 12.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Cas1_AcylT PF07779.12 CDW53127.1 - 0.084 11.8 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p Forkhead PF00250.18 CDW53128.1 - 1.5e-37 127.7 0.1 2.5e-37 127.0 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain Forkhead_N PF08430.12 CDW53128.1 - 4.7e-08 33.7 27.2 4.7e-08 33.7 27.2 5.1 3 1 1 4 4 4 1 Forkhead N-terminal region HNF_C PF09354.10 CDW53128.1 - 0.022 15.8 1.9 0.022 15.8 1.9 4.8 3 2 0 3 3 3 0 HNF3 C-terminal domain CS PF04969.16 CDW53131.1 - 5.6e-14 52.9 0.0 8.7e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 CS domain SGS PF05002.15 CDW53131.1 - 9.4e-05 22.5 0.2 0.00019 21.5 0.2 1.5 1 0 0 1 1 1 1 SGS domain Siah-Interact_N PF09032.11 CDW53131.1 - 0.00034 20.9 0.7 0.00069 19.9 0.7 1.5 1 0 0 1 1 1 1 Siah interacting protein, N terminal UQ_con PF00179.26 CDW53133.1 - 3.5e-50 169.3 0.0 4.2e-50 169.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDW53133.1 - 1.9e-05 24.4 0.0 2.7e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B BRE PF06113.12 CDW53133.1 - 0.16 10.8 0.1 0.17 10.7 0.1 1.1 1 0 0 1 1 1 0 Brain and reproductive organ-expressed protein (BRE) Pkinase PF00069.25 CDW53135.1 - 6.5e-25 88.0 0.0 8.7e-25 87.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53135.1 - 3.2e-13 49.6 0.0 4.5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW53135.1 - 8.3e-10 38.0 0.1 1.1e-09 37.6 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 CDW53135.1 - 0.0093 16.1 0.1 0.033 14.3 0.0 1.9 3 0 0 3 3 3 1 ABC1 family ORF11CD3 PF10549.9 CDW53136.1 - 0.2 11.8 0.2 0.36 11.0 0.2 1.4 1 0 0 1 1 1 0 ORF11CD3 domain Ras PF00071.22 CDW53137.1 - 1e-57 194.2 0.1 1.2e-57 194.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW53137.1 - 2.3e-20 73.0 0.0 3.1e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW53137.1 - 2e-10 40.4 0.0 2.3e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CDW53137.1 - 1e-05 25.5 0.0 0.034 14.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDW53137.1 - 0.00087 19.4 0.1 0.0012 18.9 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDW53137.1 - 0.0045 16.6 0.4 0.027 14.0 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 CDW53137.1 - 0.015 14.3 0.1 0.26 10.2 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ParA PF10609.9 CDW53137.1 - 0.091 12.2 0.2 0.64 9.4 0.0 2.0 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase NTPase_1 PF03266.15 CDW53137.1 - 0.11 12.4 0.2 0.14 12.0 0.2 1.3 1 0 0 1 1 1 0 NTPase G-alpha PF00503.20 CDW53137.1 - 0.11 11.6 0.1 0.7 9.0 0.1 2.1 1 1 0 1 1 1 0 G-protein alpha subunit DUF3337 PF11816.8 CDW53138.1 - 1.8e-42 145.1 0.0 6.5e-41 140.1 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 CDW53138.1 - 9e-26 89.6 15.9 0.00067 20.4 0.6 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53138.1 - 0.00014 22.1 2.2 0.21 11.9 0.1 4.6 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW53138.1 - 0.019 13.9 0.1 0.77 8.7 0.0 2.3 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 CDW53138.1 - 0.058 12.1 1.1 9.3 4.9 0.0 3.4 4 1 0 4 4 4 0 Nup133 N terminal like RAWUL PF16207.5 CDW53138.1 - 0.11 13.1 0.0 0.25 12.0 0.0 1.6 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like Nup160 PF11715.8 CDW53138.1 - 1.4 7.5 7.0 3 6.4 0.1 3.6 1 1 1 4 4 4 0 Nucleoporin Nup120/160 Gal-bind_lectin PF00337.22 CDW53139.1 - 1.4e-27 95.9 0.3 1.6e-27 95.6 0.3 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin Trypsin PF00089.26 CDW53140.1 - 5.5e-17 62.3 0.0 4.2e-16 59.4 0.0 2.0 1 1 0 1 1 1 1 Trypsin CUB PF00431.20 CDW53140.1 - 1.8e-11 44.3 0.2 2.6e-06 27.7 0.0 2.6 2 0 0 2 2 2 2 CUB domain DUF316 PF03761.15 CDW53140.1 - 0.0092 15.6 0.0 0.036 13.6 0.0 1.9 2 0 0 2 2 2 1 Chymotrypsin family Peptidase-S1 Ldl_recept_a PF00057.18 CDW53140.1 - 0.025 14.8 2.3 0.075 13.3 2.3 1.9 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A WD40 PF00400.32 CDW53141.1 - 0.00033 21.4 3.6 0.23 12.4 0.1 4.9 4 1 0 4 4 4 2 WD domain, G-beta repeat GTP_EFTU PF00009.27 CDW53142.1 - 9.6e-57 191.7 0.0 1.5e-56 191.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDW53142.1 - 4.4e-42 142.9 0.0 1.2e-41 141.5 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDW53142.1 - 6.3e-15 55.3 2.7 8.1e-15 55.0 0.6 2.3 2 1 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW53142.1 - 8e-05 22.7 0.1 0.0021 18.1 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CDW53142.1 - 0.0039 17.1 2.1 0.004 17.0 0.3 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 Semialdhyde_dhC PF02774.18 CDW53142.1 - 0.023 14.8 0.4 0.2 11.7 0.1 2.1 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain Dynamin_N PF00350.23 CDW53142.1 - 0.13 12.3 0.1 17 5.4 0.1 2.4 2 0 0 2 2 2 0 Dynamin family zf-C2H2_4 PF13894.6 CDW53143.1 - 5.9e-10 39.1 53.4 0.22 12.5 3.6 7.3 7 0 0 7 7 7 6 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW53143.1 - 0.0036 17.7 59.7 0.19 12.2 5.0 7.0 7 1 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CDW53143.1 - 0.0052 16.7 0.2 0.0052 16.7 0.2 5.2 5 1 0 5 5 5 2 C2H2-type zinc finger zf-CRD PF17979.1 CDW53143.1 - 0.13 12.3 0.2 0.13 12.3 0.2 5.0 5 2 0 5 5 5 0 Cysteine rich domain with multizinc binding regions zf-C2H2_3rep PF18868.1 CDW53143.1 - 0.18 12.5 13.7 13 6.5 0.3 4.7 4 1 0 5 5 4 0 Zinc finger C2H2-type, 3 repeats Evr1_Alr PF04777.13 CDW53143.1 - 0.39 11.2 6.5 1.3 9.5 0.1 4.0 3 1 1 4 4 4 0 Erv1 / Alr family zf_Hakai PF18408.1 CDW53143.1 - 0.58 9.9 6.2 1.8 8.3 6.2 1.8 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain zf-C2H2_2 PF12756.7 CDW53143.1 - 1.7 9.1 25.7 1.8 9.0 0.6 5.6 5 1 1 6 6 6 0 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 CDW53143.1 - 2.4 7.9 9.6 13 5.6 0.4 3.6 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf_ZIC PF18366.1 CDW53143.1 - 4.5 7.4 8.1 90 3.3 0.0 4.0 4 0 0 4 4 3 0 Zic proteins zinc finger domain zf-met PF12874.7 CDW53143.1 - 5.9 7.4 33.4 1.9 9.0 2.5 6.1 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Zn_Tnp_IS1595 PF12760.7 CDW53143.1 - 9.9 6.2 9.3 18 5.4 0.3 3.7 4 0 0 4 4 4 0 Transposase zinc-ribbon domain YAF2_RYBP PF17219.3 CDW53144.1 - 6.4e-13 48.0 0.1 1.3e-12 47.1 0.1 1.6 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif zf-RanBP PF00641.18 CDW53144.1 - 6.8e-08 31.7 2.1 1.3e-07 30.8 2.1 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others C1_2 PF03107.16 CDW53144.1 - 0.02 15.2 1.3 0.043 14.1 1.3 1.5 1 0 0 1 1 1 0 C1 domain Ephrin_rec_like PF07699.13 CDW53144.1 - 0.13 12.0 2.3 0.38 10.6 2.3 1.8 1 0 0 1 1 1 0 Putative ephrin-receptor like Glyco_hydro_18 PF00704.28 CDW53145.1 - 6.9e-13 49.0 0.0 2.1e-11 44.1 0.0 2.0 1 1 0 2 2 2 2 Glycosyl hydrolases family 18 Sec15 PF04091.12 CDW53146.1 - 1.5e-69 234.8 0.0 3.6e-69 233.6 0.0 1.7 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like COG2 PF06148.11 CDW53146.1 - 2.2e-05 24.6 1.1 2.2e-05 24.6 1.1 3.2 3 1 1 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 CDW53146.1 - 2.3e-05 24.4 0.1 0.00024 21.1 0.0 2.8 2 0 0 2 2 2 1 Vps51/Vps67 DUF760 PF05542.11 CDW53146.1 - 0.00039 20.7 0.5 0.022 15.1 0.0 3.6 5 0 0 5 5 5 1 Protein of unknown function (DUF760) Zw10 PF06248.13 CDW53146.1 - 0.00061 18.5 0.2 0.0013 17.4 0.2 1.5 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Csm1_B PF18211.1 CDW53146.1 - 0.0033 17.2 1.1 0.31 10.9 0.0 3.4 3 0 0 3 3 3 1 Csm1 subunit domain B DUF2894 PF11445.8 CDW53146.1 - 0.021 15.3 0.2 0.066 13.7 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) DUF848 PF05852.11 CDW53146.1 - 0.18 11.9 1.2 2.7 8.1 0.0 2.9 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) COG5 PF10392.9 CDW53146.1 - 0.2 11.8 1.3 1.2 9.3 0.1 2.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Fib_alpha PF08702.10 CDW53146.1 - 1.2 9.3 3.5 5.1 7.3 0.2 3.3 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family CK2S PF15011.6 CDW53146.1 - 1.5 8.7 5.6 0.82 9.5 1.0 2.9 2 1 1 3 3 3 0 Casein Kinase 2 substrate FliJ PF02050.16 CDW53146.1 - 4 7.7 6.5 50 4.1 0.0 3.8 3 0 0 3 3 3 0 Flagellar FliJ protein Aminotran_5 PF00266.19 CDW53147.1 - 4e-43 147.8 0.0 4.6e-43 147.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CDW53147.1 - 0.00023 20.5 0.0 0.28 10.3 0.0 2.3 2 1 0 2 2 2 2 Aminotransferase class I and II A_deaminase PF00962.22 CDW53148.1 - 4e-72 243.3 0.0 4.5e-72 243.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Bunya_RdRp PF04196.12 CDW53149.1 - 0.055 11.8 1.6 0.083 11.2 1.6 1.2 1 0 0 1 1 1 0 Bunyavirus RNA dependent RNA polymerase Stap_Strp_tox_C PF02876.17 CDW53149.1 - 0.092 13.1 0.2 0.19 12.1 0.2 1.5 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain Mei5 PF10376.9 CDW53149.1 - 0.21 11.4 9.9 0.05 13.5 6.3 1.7 1 1 1 2 2 2 0 Double-strand recombination repair protein DUF4164 PF13747.6 CDW53149.1 - 1.5 9.2 10.0 6.7 7.1 2.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) PEP-utilisers_N PF05524.13 CDW53149.1 - 6.3 7.0 5.9 1.5 9.0 1.2 2.2 2 1 1 3 3 3 0 PEP-utilising enzyme, N-terminal Peptidase_C1 PF00112.23 CDW53150.1 - 1.6e-127 423.9 37.1 1.4e-53 182.2 4.8 5.8 5 1 1 6 6 6 6 Papain family cysteine protease Propeptide_C1 PF08127.13 CDW53150.1 - 0.0005 19.9 0.0 0.54 10.2 0.0 3.5 3 0 0 3 3 3 2 Peptidase family C1 propeptide Skp1 PF01466.19 CDW53150.1 - 0.13 12.4 0.0 52 4.1 0.0 3.7 4 0 0 4 4 4 0 Skp1 family, dimerisation domain MerR-DNA-bind PF09278.11 CDW53150.1 - 0.25 11.9 0.4 1.4e+02 3.1 0.0 3.9 4 0 0 4 4 4 0 MerR, DNA binding Retrotran_gag_2 PF14223.6 CDW53151.1 - 1.1e-26 93.1 1.0 1.8e-26 92.4 1.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDW53151.1 - 1.2e-22 80.3 0.0 3.3e-22 78.9 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain RVT_2 PF07727.14 CDW53151.1 - 1.1e-16 61.2 0.1 1.9e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag_pre-integrs PF13976.6 CDW53151.1 - 4.5e-10 39.3 0.0 1.1e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain zf-CCHC PF00098.23 CDW53151.1 - 7.1e-05 22.7 0.7 0.00026 20.9 0.7 2.1 1 0 0 1 1 1 1 Zinc knuckle Retrotrans_gag PF03732.17 CDW53151.1 - 0.00062 20.0 0.2 0.0034 17.6 0.0 2.3 2 0 0 2 2 2 1 Retrotransposon gag protein DDE_Tnp_IS240 PF13610.6 CDW53151.1 - 0.00076 19.7 0.0 0.0025 18.1 0.0 1.8 1 0 0 1 1 1 1 DDE domain rve_3 PF13683.6 CDW53151.1 - 0.001 18.8 0.0 0.003 17.3 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Retrotran_gag_3 PF14244.6 CDW53151.1 - 0.09 12.6 0.1 0.27 11.1 0.1 1.9 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF2574 PF10836.8 CDW53151.1 - 0.12 12.3 0.1 0.42 10.5 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2574) YqfQ PF14181.6 CDW53151.1 - 0.3 11.3 1.1 0.63 10.2 1.1 1.5 1 0 0 1 1 1 0 YqfQ-like protein zf-CCHC_4 PF14392.6 CDW53151.1 - 0.33 10.7 2.8 0.52 10.1 1.6 2.0 2 0 0 2 2 2 0 Zinc knuckle Proton_antipo_M PF00361.20 CDW53152.1 - 4.8e-07 29.3 2.9 4.8e-07 29.3 2.9 1.6 2 0 0 2 2 2 1 Proton-conducting membrane transporter N6-adenineMlase PF10237.9 CDW53153.1 - 5.2e-18 65.4 0.0 8.3e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase DHHC PF01529.20 CDW53153.1 - 9.6 6.3 21.9 0.48 10.5 11.7 2.5 1 1 1 2 2 2 0 DHHC palmitoyltransferase 7tm_1 PF00001.21 CDW53154.1 - 1.7e-08 34.2 17.7 2.2e-08 33.8 17.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW53154.1 - 8.2e-08 31.9 17.3 8.2e-08 31.9 17.3 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW53154.1 - 1.5e-07 31.3 16.5 2.3e-07 30.7 16.5 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 CDW53154.1 - 0.0002 20.9 12.1 0.0002 20.9 12.1 2.1 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc DUF973 PF06157.11 CDW53154.1 - 3.1 6.8 11.4 0.75 8.8 1.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF973) 7tm_1 PF00001.21 CDW53155.1 - 0.56 9.5 15.8 1.4 8.2 15.3 1.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TUSC2 PF15000.6 CDW53156.1 - 3.2e-16 59.6 0.0 3.5e-16 59.5 0.0 1.0 1 0 0 1 1 1 1 Tumour suppressor candidate 2 Cren7 PF11520.8 CDW53156.1 - 0.042 13.8 0.1 0.059 13.3 0.1 1.2 1 0 0 1 1 1 0 Chromatin protein Cren7 RA PF00788.23 CDW53157.1 - 2.1e-18 66.7 0.1 4.2e-18 65.8 0.1 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain C1_1 PF00130.22 CDW53157.1 - 2.4e-14 52.9 9.9 6.7e-14 51.5 9.9 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH PF16517.5 CDW53157.1 - 3.1e-11 43.0 3.5 5.1e-11 42.3 3.5 1.4 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain C1_2 PF03107.16 CDW53157.1 - 0.065 13.6 9.1 0.085 13.2 5.9 2.4 2 0 0 2 2 2 0 C1 domain CPSase_L_D2 PF02786.17 CDW53158.1 - 8.1e-74 247.7 0.0 1.2e-73 247.1 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDW53158.1 - 3.4e-45 153.1 0.1 9.1e-45 151.7 0.0 1.8 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDW53158.1 - 3e-26 91.6 0.0 7.1e-26 90.4 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CDW53158.1 - 2e-11 43.5 0.2 4.3e-11 42.5 0.2 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CDW53158.1 - 1.6e-10 40.7 0.5 3.6e-07 29.9 0.4 2.4 2 0 0 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 CDW53158.1 - 1.7e-08 34.3 0.0 5.9e-08 32.5 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CDW53158.1 - 4.3e-07 29.7 0.0 7.7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 CDW53158.1 - 0.0013 19.4 0.1 1.1 10.0 0.0 2.5 2 0 0 2 2 2 2 HlyD family secretion protein HlyD_D23 PF16576.5 CDW53158.1 - 0.0023 17.2 0.0 0.079 12.2 0.1 2.2 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 CDW53158.1 - 0.012 15.7 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 CDW53158.1 - 0.031 14.0 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Na_Ca_ex PF01699.24 CDW53159.1 - 1e-50 171.6 37.1 1.2e-27 96.8 11.7 2.5 2 1 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 CDW53159.1 - 2.5e-24 85.3 0.5 5.2e-10 39.4 0.0 4.2 5 0 0 5 5 5 3 Calx-beta domain Na_Ca_ex_C PF16494.5 CDW53159.1 - 4.7e-05 23.9 0.2 9.9e-05 22.8 0.2 1.5 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain adh_short PF00106.25 CDW53160.1 - 1.1e-44 152.2 0.0 1.5e-44 151.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW53160.1 - 5.9e-31 107.8 0.0 7.6e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW53160.1 - 2.4e-11 43.9 0.1 3.6e-11 43.3 0.1 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CDW53160.1 - 0.015 15.2 0.4 0.023 14.6 0.4 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CDW53160.1 - 0.035 13.2 0.0 0.052 12.7 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Methyltransf_25 PF13649.6 CDW53160.1 - 0.042 14.6 0.0 0.089 13.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain 2-Hacid_dh_C PF02826.19 CDW53160.1 - 0.14 11.5 0.1 0.24 10.7 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 CDW53160.1 - 0.16 12.0 1.1 0.45 10.6 1.1 1.7 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Cupin_8 PF13621.6 CDW53161.1 - 2.4e-46 158.5 0.0 3.1e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CDW53161.1 - 2.8e-08 33.6 0.0 9.5e-08 31.9 0.0 2.0 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 CDW53161.1 - 7.2e-05 23.2 0.0 0.00025 21.5 0.0 2.0 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 CDW53161.1 - 0.007 16.1 0.0 0.024 14.3 0.0 1.8 2 0 0 2 2 2 1 Cupin domain Cupin_1 PF00190.22 CDW53161.1 - 0.078 12.6 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Cupin DUF2362 PF10154.9 CDW53162.1 - 5.4e-81 273.1 7.9 7e-79 266.1 7.9 3.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) GIT_SHD PF08518.11 CDW53162.1 - 0.074 12.7 1.4 0.12 12.0 0.0 2.1 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT DNase_II PF03265.15 CDW53163.1 - 2e-47 162.1 0.9 2.4e-47 161.8 0.9 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II AMPK1_CBM PF16561.5 CDW53163.1 - 1.4e-20 73.2 0.0 3e-20 72.2 0.0 1.5 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase DNase_II PF03265.15 CDW53164.1 - 1.3e-45 156.1 0.0 1.6e-45 155.8 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II Isochorismatase PF00857.20 CDW53165.1 - 1.3e-27 97.1 0.1 3.5e-27 95.7 0.1 1.6 1 1 0 1 1 1 1 Isochorismatase family RasGEF PF00617.19 CDW53166.1 - 1.8e-50 171.6 0.2 3.6e-50 170.6 0.2 1.6 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.24 CDW53166.1 - 2e-10 40.9 0.0 4.8e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain RasGEF_N PF00618.20 CDW53166.1 - 1.3e-09 38.2 0.5 7.1e-08 32.6 0.5 2.6 1 1 0 1 1 1 1 RasGEF N-terminal motif PDZ_6 PF17820.1 CDW53166.1 - 6.6e-08 32.3 0.0 2e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 PDZ domain cNMP_binding PF00027.29 CDW53166.1 - 1.9e-07 31.0 0.1 0.0015 18.5 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RA PF00788.23 CDW53166.1 - 2.4e-06 28.1 0.0 7.3e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ_2 PF13180.6 CDW53166.1 - 0.00014 22.1 0.0 0.00036 20.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Tfb2 PF03849.14 CDW53167.1 - 4.8e-58 196.8 0.0 6.1e-58 196.5 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 CDW53167.1 - 4.2e-15 55.9 0.1 2.5e-14 53.4 0.1 2.3 1 1 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 CDW53167.1 - 0.027 14.6 0.0 0.046 13.9 0.0 1.3 1 0 0 1 1 1 0 Helicase conserved C-terminal domain LSM PF01423.22 CDW53169.1 - 1e-18 66.7 0.2 1.3e-18 66.4 0.2 1.1 1 0 0 1 1 1 1 LSM domain Med20 PF08612.11 CDW53170.1 - 1.1e-18 67.4 0.0 1.4e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Cast PF10174.9 CDW53171.1 - 4e-77 260.2 89.7 1.3e-74 251.9 89.7 2.3 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone ABC_tran_CTD PF16326.5 CDW53171.1 - 0.0011 19.1 1.7 0.0011 19.1 1.7 10.1 5 3 4 9 9 9 2 ABC transporter C-terminal domain Shugoshin_N PF07558.11 CDW53171.1 - 0.0062 16.4 1.7 0.53 10.2 0.5 3.8 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region tRNA-synt_1c PF00749.21 CDW53172.1 - 1.1e-107 359.6 0.0 1.6e-107 359.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 CDW53172.1 - 2.8e-41 141.2 0.1 5.3e-41 140.3 0.1 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 CDW53172.1 - 1.2e-37 129.5 0.1 2.3e-37 128.5 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 CDW53172.1 - 9.7e-22 77.7 0.1 2e-21 76.7 0.1 1.6 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 E1_DerP2_DerF2 PF02221.15 CDW53173.1 - 7.6e-53 178.5 10.4 1.1e-20 74.5 0.3 3.1 3 0 0 3 3 3 3 ML domain ASH PF15780.5 CDW53173.1 - 0.026 14.7 0.1 12 6.1 0.0 2.6 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin E1_DerP2_DerF2 PF02221.15 CDW53174.1 - 0.0084 16.5 0.0 0.014 15.9 0.0 1.4 1 1 0 1 1 1 1 ML domain Wzt_C PF14524.6 CDW53175.1 - 0.037 14.1 0.0 1.8 8.6 0.0 2.1 2 0 0 2 2 2 0 Wzt C-terminal domain DNase_II PF03265.15 CDW53176.1 - 6.9e-44 150.4 1.2 1.6e-40 139.3 0.1 2.0 2 0 0 2 2 2 2 Deoxyribonuclease II EMP24_GP25L PF01105.24 CDW53177.1 - 5.7e-19 68.7 0.2 6.5e-19 68.6 0.2 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 CDW53177.1 - 0.0067 16.6 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 SdrD B-like domain EF-hand_7 PF13499.6 CDW53178.1 - 6.6e-24 84.1 1.3 7.7e-15 55.1 0.7 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW53178.1 - 1.6e-23 80.4 4.6 4.5e-07 29.0 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDW53178.1 - 4.4e-20 69.8 1.9 1.6e-05 24.5 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 CDW53178.1 - 6.3e-16 57.1 4.3 3.1e-05 23.2 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 CDW53178.1 - 9.2e-16 57.4 2.0 2.5e-06 27.2 0.0 3.5 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW53178.1 - 1e-06 29.0 0.7 0.031 14.6 0.6 3.2 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDW53178.1 - 0.00023 21.0 2.2 1.9 8.5 0.0 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CDW53178.1 - 0.0047 17.2 0.4 0.61 10.4 0.0 2.8 2 1 1 3 3 3 1 EF-hand domain RE_AlwI PF09491.10 CDW53178.1 - 0.062 12.1 0.3 0.19 10.5 0.3 1.6 1 1 1 2 2 2 0 AlwI restriction endonuclease EF-hand_14 PF17959.1 CDW53178.1 - 0.1 13.0 0.3 12 6.3 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain WD40 PF00400.32 CDW53180.1 - 5.2e-16 58.8 13.0 0.00034 21.4 0.4 6.2 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53180.1 - 9.7e-06 25.8 0.3 0.0022 18.3 0.2 3.6 3 3 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW53180.1 - 0.0013 17.4 2.2 0.65 8.6 0.0 3.2 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CDW53180.1 - 0.035 13.1 0.0 1.8 7.4 0.0 3.1 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-C2H2 PF00096.26 CDW53181.1 - 7.2e-26 89.2 61.4 6e-06 26.4 2.2 6.7 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW53181.1 - 1.1e-22 79.4 62.5 1.3e-05 25.4 0.8 7.4 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW53181.1 - 8.2e-17 60.5 54.5 0.015 16.1 1.8 6.6 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW53181.1 - 3.7e-06 27.1 37.6 0.015 15.6 0.1 6.5 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW53181.1 - 0.00011 22.0 49.7 0.0041 17.1 7.5 6.5 6 0 0 6 6 6 4 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 CDW53181.1 - 0.0018 19.0 12.9 1.1 10.1 0.5 3.4 2 1 1 3 3 3 2 zinc-ribbon family zf-met PF12874.7 CDW53181.1 - 0.0054 17.1 34.0 0.2 12.1 0.6 6.6 5 1 1 6 6 6 2 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 CDW53181.1 - 0.37 10.9 25.0 10 6.3 3.2 4.9 2 2 2 4 4 4 0 Zinc ribbon domain ADK_lid PF05191.14 CDW53181.1 - 0.42 10.6 20.5 2.2 8.4 2.4 4.8 2 2 0 2 2 2 0 Adenylate kinase, active site lid BolA PF01722.18 CDW53181.1 - 0.76 10.1 4.1 11 6.4 1.5 2.8 2 1 0 2 2 2 0 BolA-like protein zf_UBZ PF18439.1 CDW53181.1 - 0.87 9.2 0.1 0.87 9.2 0.1 5.6 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Acetone_carb_G PF08882.11 CDW53181.1 - 0.9 9.7 4.4 12 6.1 0.0 3.1 1 1 1 3 3 3 0 Acetone carboxylase gamma subunit Rep_fac-A_C PF08646.10 CDW53181.1 - 0.94 9.2 8.6 5.3 6.8 0.5 2.9 3 0 0 3 3 3 0 Replication factor-A C terminal domain zf-Sec23_Sec24 PF04810.15 CDW53181.1 - 2.2 8.4 29.9 56 3.9 0.2 6.4 4 2 1 6 6 5 0 Sec23/Sec24 zinc finger zf-AN1 PF01428.16 CDW53181.1 - 2.3 8.4 35.3 1.2 9.3 2.5 6.5 5 1 1 6 6 6 0 AN1-like Zinc finger GAGA PF09237.11 CDW53181.1 - 4.4 7.2 11.1 16 5.4 0.1 4.4 2 2 3 5 5 5 0 GAGA factor zf-CCHC_2 PF13696.6 CDW53181.1 - 6 6.8 20.6 4.1 7.3 0.7 4.6 5 0 0 5 5 4 0 Zinc knuckle zf-C2H2_9 PF16293.5 CDW53181.1 - 6.6 6.7 12.3 25 4.8 0.1 4.3 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) Trypsin PF00089.26 CDW53182.1 - 1.5e-05 24.9 0.4 2.8e-05 24.0 0.4 1.4 1 1 0 1 1 1 1 Trypsin AdoHcyase PF05221.17 CDW53183.1 - 8.3e-106 353.5 0.0 2.2e-58 197.8 0.2 2.3 2 1 1 3 3 3 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CDW53183.1 - 1.8e-63 213.4 2.5 2.6e-63 212.9 2.5 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDW53183.1 - 4.6e-11 42.4 0.1 8.8e-11 41.5 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CDW53183.1 - 1.1e-06 28.3 0.1 1.9e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 CDW53183.1 - 0.0013 18.8 0.3 0.0035 17.4 0.3 1.7 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CDW53183.1 - 0.0048 17.3 1.0 0.015 15.7 0.8 1.9 2 0 0 2 2 2 1 Putative NAD(P)-binding TrkA_N PF02254.18 CDW53183.1 - 0.0055 17.0 0.3 0.02 15.2 0.3 2.0 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.15 CDW53183.1 - 0.018 15.2 0.2 0.035 14.3 0.2 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase OCD_Mu_crystall PF02423.15 CDW53183.1 - 0.058 12.3 0.2 0.11 11.4 0.1 1.5 2 0 0 2 2 2 0 Ornithine cyclodeaminase/mu-crystallin family Oxidored_nitro PF00148.19 CDW53183.1 - 0.07 11.9 0.0 0.14 10.8 0.0 1.6 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase XdhC_C PF13478.6 CDW53183.1 - 0.13 12.8 0.4 0.36 11.4 0.1 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain ELFV_dehydrog PF00208.21 CDW53185.1 - 2.9e-51 174.5 0.0 4.2e-51 174.0 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 CDW53185.1 - 3.3e-50 169.3 0.0 4.5e-48 162.4 0.0 2.3 1 1 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Tim17 PF02466.19 CDW53186.1 - 8e-28 97.0 7.1 1.1e-27 96.6 7.1 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_5_1 PF06946.11 CDW53186.1 - 0.025 14.9 0.4 0.025 14.9 0.4 1.6 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 DUF347 PF03988.12 CDW53186.1 - 0.13 12.4 4.4 0.29 11.4 4.4 1.5 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) MARVEL PF01284.23 CDW53187.1 - 1.8e-06 28.0 16.7 2.9e-06 27.4 16.7 1.4 1 0 0 1 1 1 1 Membrane-associating domain Tetraspanin PF00335.20 CDW53187.1 - 0.84 9.3 7.2 1.1 8.9 7.2 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF202 PF02656.15 CDW53187.1 - 4.3 7.8 10.2 49 4.5 8.3 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF202) HALZ PF02183.18 CDW53188.1 - 0.005 17.0 0.1 0.048 13.9 0.1 2.3 2 0 0 2 2 2 1 Homeobox associated leucine zipper Rho_Binding PF08912.11 CDW53188.1 - 2.4 9.0 5.5 18 6.2 0.4 2.9 3 1 0 3 3 3 0 Rho Binding 7tm_1 PF00001.21 CDW53189.1 - 2.8e-24 85.8 11.1 4.5e-24 85.2 11.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW53189.1 - 8.5e-07 28.9 8.6 8.5e-07 28.9 8.6 2.2 3 0 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx COX7a PF02238.15 CDW53189.1 - 0.55 10.7 2.3 1 9.8 0.1 2.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII Ig_3 PF13927.6 CDW53190.1 - 3.2e-15 56.5 0.0 4.7e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 CDW53190.1 - 1.1e-13 51.1 0.0 1.4e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 CDW53190.1 - 6.1e-13 48.8 0.1 9.5e-13 48.1 0.1 1.3 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 CDW53190.1 - 6.6e-09 36.0 0.1 1.5e-08 34.8 0.1 1.6 1 1 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 CDW53190.1 - 1.1e-05 25.4 0.1 1.7e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 CD80-like C2-set immunoglobulin domain V-set PF07686.17 CDW53190.1 - 3.7e-05 23.9 0.1 0.00037 20.6 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_4 PF16680.5 CDW53190.1 - 0.02 15.2 0.2 0.44 10.8 0.2 2.2 1 1 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain EGF_2 PF07974.13 CDW53191.1 - 0.00096 19.5 21.5 0.61 10.5 2.0 4.7 4 0 0 4 4 4 3 EGF-like domain DSL PF01414.19 CDW53191.1 - 0.0014 18.9 11.1 0.012 15.8 0.6 3.0 1 1 1 2 2 2 2 Delta serrate ligand Laminin_EGF PF00053.24 CDW53191.1 - 0.034 14.3 18.3 4.1 7.6 5.9 3.8 1 1 2 3 3 3 0 Laminin EGF domain TMEM144 PF07857.12 CDW53191.1 - 0.14 11.1 0.1 0.19 10.7 0.1 1.1 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters Insulin_TMD PF17870.1 CDW53191.1 - 0.2 11.7 0.6 0.36 10.9 0.6 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RRM_1 PF00076.22 CDW53192.1 - 1.9e-13 50.0 0.0 2.6e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDW53192.1 - 0.0028 17.6 0.1 0.0038 17.2 0.1 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CDW53192.1 - 0.068 13.0 0.0 0.089 12.7 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif AAA PF00004.29 CDW53193.1 - 3.5e-42 144.0 0.0 1.2e-41 142.2 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDW53193.1 - 7.3e-10 38.7 0.2 1.4e-09 37.8 0.2 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CDW53193.1 - 9.1e-10 38.2 0.4 1.6e-09 37.4 0.4 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 CDW53193.1 - 2.1e-06 28.0 0.0 4.6e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDW53193.1 - 8.6e-06 26.1 0.3 0.0059 16.9 0.3 2.6 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDW53193.1 - 1.4e-05 24.4 0.0 2.4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 CDW53193.1 - 0.00013 21.9 0.1 0.00086 19.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW53193.1 - 0.00016 22.1 0.2 0.0075 16.7 0.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CDW53193.1 - 0.0003 20.6 0.0 0.00061 19.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CDW53193.1 - 0.0021 18.3 0.3 0.0046 17.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain Prot_ATP_OB_N PF17758.1 CDW53193.1 - 0.0039 16.8 0.1 0.014 15.1 0.0 1.9 2 0 0 2 2 1 1 Proteasomal ATPase OB N-terminal domain ATPase PF06745.13 CDW53193.1 - 0.0057 16.0 0.1 0.37 10.1 0.1 2.2 1 1 1 2 2 2 1 KaiC AAA_33 PF13671.6 CDW53193.1 - 0.0067 16.6 0.0 0.019 15.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 CDW53193.1 - 0.0068 16.0 0.6 0.52 9.9 0.4 2.5 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDW53193.1 - 0.0075 16.6 0.0 0.032 14.6 0.0 2.0 2 0 0 2 2 2 1 RNA helicase AAA_3 PF07726.11 CDW53193.1 - 0.011 15.6 0.1 0.054 13.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDW53193.1 - 0.012 16.2 0.0 0.031 14.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDW53193.1 - 0.014 15.1 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 CDW53193.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CDW53193.1 - 0.045 12.9 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 CDW53193.1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CDW53193.1 - 0.069 12.9 0.4 0.28 10.9 0.2 2.1 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 CDW53193.1 - 0.078 12.9 0.1 0.59 10.0 0.1 2.1 1 1 1 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 CDW53193.1 - 0.12 11.7 0.1 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.16 CDW53193.1 - 0.12 11.8 0.2 0.5 9.8 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein TsaE PF02367.17 CDW53193.1 - 0.16 11.9 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 CDW53193.1 - 0.17 11.1 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CDW53193.1 - 0.18 11.5 0.4 0.42 10.3 0.4 1.6 1 1 0 1 1 1 0 AAA domain 7tm_1 PF00001.21 CDW53194.1 - 1.7e-06 27.6 13.5 3.6e-06 26.5 13.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW53194.1 - 8.4e-05 22.1 13.1 8.4e-05 22.1 13.1 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx RalF_SCD PF18248.1 CDW53194.1 - 0.074 13.0 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 RalF C-terminal Sec-7 capping domain DUF4293 PF14126.6 CDW53194.1 - 4 7.7 15.7 7.4 6.8 1.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) DUF1418 PF07214.12 CDW53194.1 - 4.6 7.2 7.3 0.69 9.8 1.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1418) E1_DerP2_DerF2 PF02221.15 CDW53195.1 - 2.9e-28 99.0 2.8 1.5e-13 51.3 0.2 2.0 2 0 0 2 2 2 2 ML domain Wzt_C PF14524.6 CDW53195.1 - 0.00039 20.5 0.0 7.7 6.6 0.0 3.9 3 1 0 4 4 4 1 Wzt C-terminal domain AHSA1 PF08327.11 CDW53195.1 - 0.005 17.1 0.0 10 6.3 0.0 3.6 2 2 2 4 4 4 1 Activator of Hsp90 ATPase homolog 1-like protein Fibrinogen_C PF00147.18 CDW53195.1 - 0.036 13.9 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 Fibrinogen beta and gamma chains, C-terminal globular domain ASH PF15780.5 CDW53195.1 - 0.093 13.0 0.0 1.4 9.2 0.0 2.4 2 1 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Disintegrin PF00200.23 CDW53195.1 - 0.13 13.1 2.3 11 6.9 0.0 3.0 4 0 0 4 4 4 0 Disintegrin KorB_C PF06613.11 CDW53195.1 - 0.2 11.6 0.2 7.5 6.6 0.1 2.4 2 0 0 2 2 2 0 KorB C-terminal beta-barrel domain vATP-synt_AC39 PF01992.16 CDW53196.1 - 3e-116 388.6 0.3 3.3e-116 388.5 0.3 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit E1_dh PF00676.20 CDW53197.1 - 3e-114 381.0 0.0 3.4e-114 380.8 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CDW53197.1 - 0.00094 18.5 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Arm-DNA-bind_4 PF14657.6 CDW53197.1 - 0.18 11.6 0.4 0.87 9.4 0.1 2.2 2 0 0 2 2 2 0 Arm DNA-binding domain MHYT PF03707.16 CDW53198.1 - 0.074 13.2 1.0 0.1 12.8 1.0 1.3 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat MFS_2 PF13347.6 CDW53198.1 - 0.081 11.5 0.0 0.087 11.4 0.0 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein Rax2 PF12768.7 CDW53198.1 - 0.11 11.9 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Pkinase PF00069.25 CDW53199.1 - 9.7e-05 21.9 0.0 0.00082 18.8 0.0 1.9 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53199.1 - 0.023 14.0 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase CH PF00307.31 CDW53201.1 - 4.6e-25 87.9 0.3 5.6e-25 87.6 0.3 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 CDW53201.1 - 0.001 18.9 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.11 CDW53201.1 - 0.003 17.8 0.2 0.0053 17.0 0.2 1.3 1 0 0 1 1 1 1 CDC24 Calponin CDC37_M PF08565.11 CDW53202.1 - 5.5e-23 81.1 0.4 1.2e-22 80.0 0.4 1.6 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_N PF03234.14 CDW53202.1 - 1.9e-15 57.9 6.4 1.9e-15 57.9 6.4 2.7 2 1 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_C PF08564.10 CDW53202.1 - 8.2e-11 41.9 0.1 8.2e-11 41.9 0.1 3.0 2 2 1 3 3 3 1 Cdc37 C terminal domain DUF668 PF05003.12 CDW53202.1 - 0.16 12.4 5.7 5.2 7.6 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF668) Exonuc_VII_L PF02601.15 CDW53202.1 - 0.21 11.1 7.7 0.36 10.4 1.9 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Dus PF01207.17 CDW53202.1 - 0.68 9.0 6.3 0.15 11.1 1.4 2.1 3 0 0 3 3 3 0 Dihydrouridine synthase (Dus) GvpL_GvpF PF06386.11 CDW53202.1 - 0.81 9.6 10.4 2.4 8.0 0.3 2.2 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF FapA PF03961.13 CDW53202.1 - 5.9 5.4 10.4 9.2 4.7 4.4 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A DNA_repr_REX1B PF14966.6 CDW53202.1 - 6.8 7.4 14.5 3 8.6 1.3 3.4 3 1 1 4 4 4 0 DNA repair REX1-B RRM_1 PF00076.22 CDW53203.1 - 9.6e-27 92.6 0.7 3.1e-13 49.3 0.0 2.9 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TDP43_N PF18694.1 CDW53203.1 - 5.4e-19 67.8 0.0 8.9e-19 67.1 0.0 1.3 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_7 PF16367.5 CDW53203.1 - 1.3e-05 25.2 0.2 0.089 12.9 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 CDW53203.1 - 0.037 14.3 0.0 37 4.5 0.0 3.1 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 CDW53203.1 - 0.1 12.6 0.1 4.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF2615 PF11027.8 CDW53204.1 - 0.026 14.7 0.7 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) Orthopox_A36R PF05950.11 CDW53204.1 - 0.067 13.4 0.2 0.084 13.0 0.2 1.2 1 0 0 1 1 1 0 Orthopoxvirus A36R protein BORA_N PF15280.6 CDW53205.1 - 2.7e-05 23.9 0.1 6.4e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 Protein aurora borealis N-terminus Cid2 PF09774.9 CDW53206.1 - 6.2e-08 33.2 7.9 1.3e-06 29.0 7.9 2.0 1 1 0 1 1 1 1 Caffeine-induced death protein 2 PAPS_reduct PF01507.19 CDW53206.1 - 0.013 15.5 0.3 0.017 15.2 0.3 1.2 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DUF2721 PF11026.8 CDW53206.1 - 0.17 11.8 1.6 0.32 10.9 1.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) VAPB_antitox PF02697.14 CDW53206.1 - 0.23 12.3 4.3 0.38 11.6 1.5 2.4 2 1 0 2 2 2 0 Putative antitoxin Ribosomal_L22 PF00237.19 CDW53206.1 - 0.65 10.3 3.8 1.3 9.3 3.8 1.6 1 1 0 1 1 1 0 Ribosomal protein L22p/L17e Ank_2 PF12796.7 CDW53208.1 - 3.9e-22 78.6 0.0 1.9e-10 41.2 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 CDW53208.1 - 5.8e-18 64.5 1.0 8.7e-06 26.0 0.0 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 CDW53208.1 - 5.3e-17 60.2 2.1 0.00013 22.1 0.0 5.6 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 CDW53208.1 - 4.2e-14 52.7 4.9 0.003 18.1 0.0 5.3 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW53208.1 - 2.2e-10 40.6 3.3 0.0038 17.5 0.0 5.1 2 1 4 6 6 6 3 Ankyrin repeats (many copies) SOCS_box PF07525.16 CDW53208.1 - 1.9e-05 24.9 0.1 1.9e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 SOCS box Ras PF00071.22 CDW53209.1 - 3.4e-61 205.6 1.2 4.1e-61 205.3 1.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW53209.1 - 5.3e-34 117.0 0.8 7.9e-34 116.5 0.8 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW53209.1 - 1.2e-13 50.9 0.1 1.6e-13 50.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CDW53209.1 - 5.2e-05 22.7 0.1 0.00016 21.2 0.1 1.8 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDW53209.1 - 6.4e-05 23.0 0.1 0.00014 21.9 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW53209.1 - 0.00052 19.4 0.1 0.0007 19.0 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 CDW53209.1 - 0.0015 18.1 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDW53209.1 - 0.0018 17.9 0.1 0.0075 15.8 0.1 2.0 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW53209.1 - 0.0061 16.5 0.1 0.56 10.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 CDW53209.1 - 0.07 12.8 0.3 0.17 11.6 0.3 1.8 1 1 0 1 1 1 0 AAA domain DUF2757 PF10955.8 CDW53209.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) G-alpha PF00503.20 CDW53209.1 - 0.31 10.1 2.1 20 4.2 0.3 2.9 1 1 1 2 2 2 0 G-protein alpha subunit Tuberin PF03542.16 CDW53210.1 - 1.3e-57 195.6 0.2 2.4e-57 194.7 0.2 1.4 1 0 0 1 1 1 1 Tuberin DUF3384 PF11864.8 CDW53210.1 - 8.5e-54 183.2 1.3 5.9e-53 180.5 0.4 2.5 1 1 1 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 CDW53210.1 - 5.4e-37 127.1 0.0 9e-37 126.4 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP UPF0489 PF12640.7 CDW53210.1 - 0.0012 19.1 0.0 0.0028 17.9 0.0 1.5 1 0 0 1 1 1 1 UPF0489 domain R3H PF01424.22 CDW53210.1 - 0.075 13.0 0.3 0.24 11.4 0.3 1.8 1 0 0 1 1 1 0 R3H domain Motile_Sperm PF00635.26 CDW53211.1 - 2e-17 63.0 1.1 2.7e-17 62.6 0.1 1.7 2 0 0 2 2 2 1 MSP (Major sperm protein) domain YqfD PF06898.11 CDW53211.1 - 0.078 11.8 3.8 0.12 11.1 3.8 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD NPR3 PF03666.13 CDW53211.1 - 0.16 10.8 5.4 0.22 10.3 5.3 1.4 1 1 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AAA PF00004.29 CDW53212.1 - 1.3e-37 129.2 0.0 2.9e-37 128.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW53212.1 - 5.5e-13 48.5 1.4 5.1e-12 45.4 0.2 2.8 2 0 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 CDW53212.1 - 2.6e-10 40.1 0.0 6.8e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 CDW53212.1 - 0.0002 21.1 0.0 0.00037 20.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CDW53212.1 - 0.00025 21.2 0.0 0.00073 19.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CDW53212.1 - 0.00043 20.3 0.0 0.0016 18.5 0.0 2.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDW53212.1 - 0.00048 20.3 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 CDW53212.1 - 0.0029 17.4 0.0 0.0065 16.2 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDW53212.1 - 0.0031 16.9 0.1 0.036 13.5 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CDW53212.1 - 0.0043 17.3 0.5 0.044 14.0 0.6 2.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW53212.1 - 0.0044 17.4 0.1 0.014 15.8 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain TsaE PF02367.17 CDW53212.1 - 0.006 16.6 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CDW53212.1 - 0.0083 16.2 0.0 0.039 14.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CDW53212.1 - 0.016 14.4 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain PhoH PF02562.16 CDW53212.1 - 0.03 13.8 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 CDW53212.1 - 0.042 13.4 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 CDW53212.1 - 0.047 13.0 0.1 3.9 6.7 0.1 2.4 1 1 1 2 2 2 0 KaiC RNA_helicase PF00910.22 CDW53212.1 - 0.052 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 CDW53212.1 - 0.068 12.9 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDW53212.1 - 0.075 13.3 0.1 0.19 12.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW53212.1 - 0.09 13.3 0.8 0.23 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDW53212.1 - 0.1 12.5 0.1 0.22 11.4 0.1 1.6 1 1 0 1 1 1 0 NACHT domain DHO_dh PF01180.21 CDW53213.1 - 3.5e-90 302.2 0.0 4.2e-90 301.9 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Gal-bind_lectin PF00337.22 CDW53214.1 - 9.5e-62 206.4 0.1 5.7e-32 110.1 0.0 2.0 2 0 0 2 2 2 2 Galactoside-binding lectin Ras PF00071.22 CDW53215.1 - 5.8e-27 94.3 0.0 1.8e-26 92.6 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CDW53215.1 - 2.9e-13 50.1 0.0 6.3e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CDW53215.1 - 3.9e-05 23.7 0.0 6.9e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW53215.1 - 8.9e-05 21.9 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDW53215.1 - 9.6e-05 22.0 0.0 0.0012 18.4 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CDW53215.1 - 0.0046 16.4 0.0 1.4 8.3 0.0 2.9 3 0 0 3 3 3 1 ADP-ribosylation factor family Viral_helicase1 PF01443.18 CDW53215.1 - 0.0069 16.2 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 CDW53215.1 - 0.01 16.3 0.0 0.07 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain SRPRB PF09439.10 CDW53215.1 - 0.015 14.7 0.0 0.03 13.8 0.0 1.6 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit U5_2-snRNA_bdg PF10597.9 CDW53215.1 - 0.046 13.8 0.1 0.11 12.5 0.0 1.6 2 0 0 2 2 2 0 U5-snRNA binding site 2 of PrP8 ATPase PF06745.13 CDW53215.1 - 0.06 12.7 0.0 0.22 10.9 0.0 1.7 2 0 0 2 2 2 0 KaiC G-alpha PF00503.20 CDW53215.1 - 0.073 12.2 0.1 0.095 11.8 0.1 1.4 1 1 0 1 1 1 0 G-protein alpha subunit cobW PF02492.19 CDW53215.1 - 0.074 12.6 0.0 4.5 6.8 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CDW53215.1 - 0.082 12.6 0.1 0.72 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDW53215.1 - 0.093 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 CDW53215.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AIG1 PF04548.16 CDW53215.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 AIG1 family TniB PF05621.11 CDW53215.1 - 0.12 11.7 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_28 PF13521.6 CDW53215.1 - 0.16 12.2 0.1 0.4 10.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDW53215.1 - 0.23 11.3 0.0 0.52 10.2 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Neur_chan_LBD PF02931.23 CDW53217.1 - 5.5e-41 140.4 0.2 6.8e-41 140.1 0.2 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW53217.1 - 4.5e-21 76.0 6.7 1.8e-17 64.2 1.8 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Hist_deacetyl PF00850.19 CDW53218.1 - 5.4e-82 275.7 0.0 6.8e-82 275.4 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain AMP-binding PF00501.28 CDW53219.1 - 3.9e-78 262.9 0.0 2.3e-50 171.4 0.0 2.3 2 0 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 CDW53219.1 - 6.6e-17 62.3 0.3 1.3e-16 61.3 0.3 1.5 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.12 CDW53219.1 - 0.00022 21.1 0.2 0.0005 20.0 0.2 1.5 1 0 0 1 1 1 1 Gas vesicle protein G EGF PF00008.27 CDW53220.1 - 1.5e-14 54.0 17.3 2e-09 37.6 6.4 2.4 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 CDW53220.1 - 5.1e-09 36.4 13.5 6.1e-08 33.0 2.4 2.8 2 0 0 2 2 2 2 Human growth factor-like EGF EGF_2 PF07974.13 CDW53220.1 - 1.1e-07 32.0 23.7 0.00023 21.5 9.0 2.3 2 0 0 2 2 2 2 EGF-like domain EGF_CA PF07645.15 CDW53220.1 - 9e-05 22.6 6.6 9e-05 22.6 6.6 2.3 2 0 0 2 2 2 1 Calcium-binding EGF domain EGF_3 PF12947.7 CDW53220.1 - 0.0025 18.0 20.7 0.087 13.0 6.9 2.5 2 0 0 2 2 2 2 EGF domain Laminin_EGF PF00053.24 CDW53220.1 - 0.0062 16.7 17.3 0.42 10.8 6.1 2.3 1 1 1 2 2 2 1 Laminin EGF domain DUF998 PF06197.13 CDW53220.1 - 0.025 14.2 0.1 0.032 13.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF998) cEGF PF12662.7 CDW53220.1 - 0.027 14.4 1.4 0.027 14.4 1.4 2.9 2 1 0 2 2 2 0 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 CDW53220.1 - 0.042 14.2 5.6 0.042 14.2 5.6 2.3 2 0 0 2 2 2 0 Pvs28 EGF domain CD34_antigen PF06365.12 CDW53220.1 - 0.052 13.1 0.0 0.094 12.3 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family IgaA PF07095.11 CDW53220.1 - 0.14 10.1 0.1 0.16 9.9 0.1 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA DSL PF01414.19 CDW53220.1 - 5.5 7.3 15.0 12 6.3 15.0 1.6 1 0 0 1 1 1 0 Delta serrate ligand FXa_inhibition PF14670.6 CDW53220.1 - 5.9 7.3 20.6 2.6 8.4 3.5 2.5 2 0 0 2 2 2 0 Coagulation Factor Xa inhibitory site Chromo_shadow PF01393.19 CDW53221.1 - 5.4e-15 55.2 0.0 1.1e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 Chromo shadow domain GKAP PF03359.13 CDW53222.1 - 1.3e-32 113.7 7.6 5.4e-28 98.5 2.4 2.2 1 1 0 2 2 2 2 Guanylate-kinase-associated protein (GKAP) protein Dickkopf_N PF04706.12 CDW53223.1 - 2.3e-07 31.2 30.2 0.00022 21.6 11.5 2.8 2 2 0 2 2 2 2 Dickkopf N-terminal cysteine-rich region EB PF01683.18 CDW53223.1 - 6e-06 26.5 30.5 0.00064 20.0 9.1 3.9 1 1 3 4 4 4 4 EB module Nodulin_late PF07127.11 CDW53223.1 - 0.018 15.4 24.7 0.025 14.9 0.2 4.2 2 2 2 4 4 4 0 Late nodulin protein Stig1 PF04885.13 CDW53223.1 - 0.052 14.0 7.8 0.052 14.0 7.8 2.1 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 CarbpepA_inh PF02977.15 CDW53223.1 - 2.8 7.8 20.2 0.24 11.2 6.1 2.6 2 2 0 2 2 2 0 Carboxypeptidase A inhibitor Histone PF00125.24 CDW53224.1 - 2.6e-19 69.9 0.0 3.2e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CDW53224.1 - 4e-10 39.2 0.2 4e-10 39.2 0.2 1.7 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CDW53224.1 - 0.0017 18.6 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone E1-E2_ATPase PF00122.20 CDW53226.1 - 6.6e-38 130.0 0.8 6.6e-38 130.0 0.8 2.3 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CDW53226.1 - 1.4e-17 64.7 0.0 3.5e-09 37.2 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase P5-ATPase PF12409.8 CDW53226.1 - 4.4e-16 59.1 1.5 4.4e-16 59.1 1.5 3.1 4 0 0 4 4 4 1 P5-type ATPase cation transporter Cation_ATPase PF13246.6 CDW53226.1 - 7.6e-07 29.1 0.0 1.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDW53226.1 - 6.3e-05 22.6 0.4 0.0002 21.0 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DUF1435 PF07256.12 CDW53226.1 - 0.46 10.6 3.5 2.8 8.1 0.4 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) Pkinase_Tyr PF07714.17 CDW53227.1 - 1.2e-51 175.5 0.0 1.8e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 CDW53227.1 - 8.7e-44 148.0 7.2 3.3e-18 66.0 0.0 5.1 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.30 CDW53227.1 - 9.6e-43 142.8 9.5 1e-07 32.1 0.0 9.0 9 0 0 9 9 9 7 Ankyrin repeat Pkinase PF00069.25 CDW53227.1 - 6.2e-42 143.8 0.0 8.3e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 CDW53227.1 - 7.4e-36 122.1 22.0 6.1e-11 42.6 0.4 6.5 2 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW53227.1 - 1.7e-35 117.0 5.8 1.7e-05 24.8 0.0 8.8 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 CDW53227.1 - 1.6e-29 101.5 6.1 4.5e-05 23.6 0.0 7.0 2 1 4 7 7 7 6 Ankyrin repeats (many copies) ABC1 PF03109.16 CDW53227.1 - 0.0057 16.8 0.0 0.012 15.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 CDW53227.1 - 0.011 15.6 0.1 0.038 13.9 0.1 1.7 1 1 0 2 2 2 0 Phosphotransferase enzyme family PAN_1 PF00024.26 CDW53228.1 - 1.7e-08 34.3 2.9 2.9e-08 33.5 2.9 1.4 1 0 0 1 1 1 1 PAN domain CLASP_N PF12348.8 CDW53229.1 - 4.7e-29 101.6 6.0 7.2e-11 42.1 0.0 5.9 5 0 0 5 5 5 4 CLASP N terminal HEAT PF02985.22 CDW53229.1 - 8.2e-15 53.7 17.8 0.37 11.2 0.1 11.6 12 0 0 12 12 11 3 HEAT repeat Cnd1 PF12717.7 CDW53229.1 - 1e-12 48.4 9.3 0.004 17.2 0.0 7.7 7 1 1 8 8 8 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDW53229.1 - 1.6e-12 47.6 9.3 0.85 10.0 0.0 8.7 4 3 6 10 10 10 4 HEAT repeats HEAT_EZ PF13513.6 CDW53229.1 - 6.9e-05 23.3 4.9 3 8.4 0.0 6.6 6 0 0 6 6 6 2 HEAT-like repeat VHS PF00790.19 CDW53229.1 - 0.00036 20.4 0.5 4.6 7.1 0.1 5.1 4 1 1 5 5 5 1 VHS domain MMS19_N PF14500.6 CDW53229.1 - 0.007 16.0 6.1 5.5 6.5 0.7 6.2 4 3 0 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II Xpo1 PF08389.12 CDW53229.1 - 0.011 15.8 8.7 23 5.0 0.0 5.9 6 0 0 6 6 6 0 Exportin 1-like protein Rogdi_lz PF10259.9 CDW53229.1 - 0.016 14.7 0.0 0.072 12.5 0.0 2.1 2 0 0 2 2 2 0 Rogdi leucine zipper containing protein Tti2 PF10521.9 CDW53229.1 - 0.021 14.4 6.6 1.4 8.4 0.0 4.1 4 1 1 5 5 5 0 Tti2 family Cohesin_HEAT PF12765.7 CDW53229.1 - 1 9.7 4.9 1.6 9.1 0.2 3.5 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion ANAPC4_WD40 PF12894.7 CDW53230.1 - 0.0019 18.5 0.0 0.13 12.6 0.0 3.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain zinc_ribbon_16 PF17034.5 CDW53230.1 - 0.002 18.3 2.7 0.0064 16.7 2.7 1.8 1 0 0 1 1 1 1 Zinc-ribbon like family eIF2A PF08662.11 CDW53230.1 - 0.038 13.9 0.0 0.29 11.0 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DNApol3-delta_C PF09115.10 CDW53230.1 - 0.063 13.8 0.5 0.42 11.1 0.1 2.5 2 0 0 2 2 2 0 DNA polymerase III, delta subunit, C terminal WD40 PF00400.32 CDW53230.1 - 0.26 12.3 5.8 0.42 11.6 0.1 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat zinc-ribbons_6 PF07191.12 CDW53230.1 - 0.41 10.7 9.6 0.19 11.7 1.9 3.1 2 0 0 2 2 2 0 zinc-ribbons Dynein_light PF01221.18 CDW53231.1 - 4.2e-29 100.7 0.3 4.2e-29 100.7 0.3 1.5 2 0 0 2 2 2 1 Dynein light chain type 1 DDE_Tnp_ISL3 PF01610.17 CDW53231.1 - 0.023 14.4 0.2 0.032 13.9 0.2 1.2 1 0 0 1 1 1 0 Transposase adh_short PF00106.25 CDW53231.1 - 0.026 14.0 0.4 0.034 13.6 0.4 1.1 1 0 0 1 1 1 0 short chain dehydrogenase Imm70 PF15601.6 CDW53231.1 - 0.049 13.2 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 70 ATPase PF06745.13 CDW53231.1 - 0.067 12.5 1.0 0.082 12.2 1.0 1.1 1 0 0 1 1 1 0 KaiC Lys-AminoMut_A PF09043.11 CDW53231.1 - 0.072 11.5 0.1 0.088 11.3 0.1 1.2 1 1 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit DUF512 PF04459.12 CDW53231.1 - 0.09 12.0 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF512) RA PF00788.23 CDW53232.1 - 0.00014 22.5 0.0 0.00035 21.1 0.0 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PI-PLC-X PF00388.19 CDW53232.1 - 0.042 13.4 0.7 0.48 10.0 0.0 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, X domain WASH_WAHD PF11945.8 CDW53232.1 - 0.21 11.0 3.1 0.34 10.4 3.1 1.2 1 0 0 1 1 1 0 WAHD domain of WASH complex Nsp1_C PF05064.13 CDW53232.1 - 0.37 10.6 7.1 0.12 12.2 2.0 2.6 1 1 2 3 3 3 0 Nsp1-like C-terminal region CC2-LZ PF16516.5 CDW53232.1 - 0.61 10.5 12.4 1.5 9.3 0.7 3.0 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator CHD5 PF04420.14 CDW53232.1 - 0.94 9.3 3.6 2.4 8.0 3.6 1.8 1 0 0 1 1 1 0 CHD5-like protein DUF4407 PF14362.6 CDW53232.1 - 1.3 8.3 11.2 2.3 7.5 11.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 CDW53232.1 - 2.4 8.2 6.4 1.4 9.0 2.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 CDW53232.1 - 2.5 8.2 9.3 2 8.5 4.0 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding FapA PF03961.13 CDW53232.1 - 2.8 6.4 10.8 0.97 8.0 7.6 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A Phage_GP20 PF06810.11 CDW53232.1 - 6.6 6.5 8.5 14 5.5 6.7 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF724 PF05266.14 CDW53232.1 - 9.2 6.0 11.6 1.5 8.7 6.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HMG_box PF00505.19 CDW53233.1 - 1.4e-16 60.6 4.4 1.4e-16 60.6 4.4 2.2 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW53233.1 - 1.4e-06 28.8 2.9 1.4e-06 28.8 2.9 2.4 2 1 0 2 2 2 1 HMG-box domain Tma16 PF11176.8 CDW53233.1 - 0.021 14.7 2.7 0.06 13.2 2.7 1.7 1 0 0 1 1 1 0 Translation machinery-associated protein 16 TPR_MLP1_2 PF07926.12 CDW53233.1 - 0.091 12.8 7.6 0.036 14.1 4.0 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Pkinase PF00069.25 CDW53234.1 - 2e-26 92.9 0.0 3e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53234.1 - 1.9e-14 53.6 0.0 2.6e-14 53.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW53234.1 - 1.3e-08 34.1 0.2 1.5e-08 33.8 0.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase PDZ_2 PF13180.6 CDW53235.1 - 2.6e-08 34.1 0.2 0.0041 17.4 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 CDW53235.1 - 3.3e-06 26.8 0.2 0.053 13.4 0.1 2.7 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CDW53235.1 - 0.0056 17.0 1.1 0.099 13.0 0.2 2.7 3 0 0 3 3 3 1 PDZ domain PAN_1 PF00024.26 CDW53236.1 - 2e-13 50.1 13.3 9.1e-09 35.2 3.8 3.4 3 0 0 3 3 3 3 PAN domain PAN_3 PF08277.12 CDW53236.1 - 0.0043 16.8 6.3 0.097 12.5 0.3 2.7 2 0 0 2 2 2 2 PAN-like domain PAN_4 PF14295.6 CDW53236.1 - 0.029 14.3 8.3 0.18 11.7 0.6 2.9 2 0 0 2 2 2 0 PAN domain Hydrophobin_2 PF06766.11 CDW53236.1 - 0.042 13.8 0.0 0.042 13.8 0.0 2.8 3 0 0 3 3 3 0 Fungal hydrophobin PAN_2 PF08276.11 CDW53236.1 - 0.12 12.6 9.1 0.45 10.7 0.7 2.4 2 0 0 2 2 2 0 PAN-like domain DUF1298 PF06974.13 CDW53237.1 - 0.0028 17.6 0.0 0.0078 16.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) Snapin_Pallidin PF14712.6 CDW53237.1 - 2.5 8.6 5.3 0.22 11.9 0.3 1.9 2 0 0 2 2 2 0 Snapin/Pallidin DUF1768 PF08719.11 CDW53239.1 - 4.9e-34 117.9 0.0 3.5e-10 40.4 0.0 7.2 6 2 0 6 6 6 6 Domain of unknown function (DUF1768) Peptidase_M2 PF01401.18 CDW53240.1 - 1.2e-195 651.4 0.0 1.5e-195 651.1 0.0 1.1 1 0 0 1 1 1 1 Angiotensin-converting enzyme EB PF01683.18 CDW53240.1 - 3.6e-05 24.0 2.0 6.6e-05 23.1 2.0 1.4 1 0 0 1 1 1 1 EB module Acetyltransf_10 PF13673.7 CDW53240.1 - 0.044 13.7 0.1 0.35 10.8 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ubiq_cyt_C_chap PF03981.12 CDW53240.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone SH2 PF00017.24 CDW53241.1 - 3.4e-29 100.8 0.0 6.7e-14 51.7 0.0 2.8 2 0 0 2 2 2 2 SH2 domain PI3K_P85_iSH2 PF16454.5 CDW53241.1 - 1.9e-23 82.9 11.8 3.4e-23 82.0 11.8 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain BAR PF03114.18 CDW53242.1 - 4.6e-30 105.0 3.9 1.2e-29 103.7 3.9 1.6 1 1 0 1 1 1 1 BAR domain SH3_9 PF14604.6 CDW53242.1 - 2.8e-13 49.5 0.1 5.4e-13 48.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW53242.1 - 5.1e-09 35.6 0.0 1.2e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CDW53242.1 - 1.3e-08 34.4 0.0 2.2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 CDW53242.1 - 0.017 14.8 1.9 0.034 13.8 1.9 1.5 1 1 0 1 1 1 0 BAR domain of APPL family EDS1_EP PF18117.1 CDW53242.1 - 0.086 13.3 0.1 0.18 12.3 0.1 1.6 1 0 0 1 1 1 0 Enhanced disease susceptibility 1 protein EP domain Ribosomal_L7Ae PF01248.26 CDW53243.1 - 3.8e-15 55.4 0.5 8.8e-15 54.2 0.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family EGF PF00008.27 CDW53243.1 - 4.9e-06 26.7 30.4 0.00019 21.7 4.6 3.7 3 0 0 3 3 3 3 EGF-like domain EGF_2 PF07974.13 CDW53243.1 - 0.015 15.7 6.7 0.015 15.7 6.7 3.7 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 CDW53243.1 - 0.47 11.2 22.2 0.18 12.5 2.5 3.9 3 0 0 3 3 3 0 Human growth factor-like EGF DUF4713 PF15831.5 CDW53243.1 - 4.6 7.8 11.4 0.26 11.7 0.7 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4713) EGF_3 PF12947.7 CDW53243.1 - 7.9 6.8 26.4 2.6 8.3 4.6 3.8 2 1 1 3 3 3 0 EGF domain Fur_reg_FbpB PF13040.6 CDW53244.1 - 0.19 11.3 2.4 0.51 9.9 2.4 1.7 1 0 0 1 1 1 0 Fur-regulated basic protein B N_BRCA1_IG PF16158.5 CDW53245.1 - 4.8e-30 104.3 0.1 9e-30 103.4 0.1 1.5 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene zf-UBR PF02207.20 CDW53246.1 - 0.073 13.3 0.8 65 3.8 0.0 4.3 5 0 0 5 5 5 0 Putative zinc finger in N-recognin (UBR box) DUF3331 PF11811.8 CDW53246.1 - 0.14 12.0 0.2 14 5.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3331) PAS_11 PF14598.6 CDW53249.1 - 6.2e-17 61.7 0.2 8.6e-11 42.0 0.1 2.4 2 0 0 2 2 2 2 PAS domain HLH PF00010.26 CDW53249.1 - 3.1e-12 46.3 0.4 6.8e-12 45.2 0.4 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_3 PF08447.12 CDW53249.1 - 2.8e-10 40.3 0.0 5.4e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 CDW53249.1 - 1.8e-07 31.1 0.0 4.6e-06 26.6 0.0 2.6 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 CDW53249.1 - 5.9e-05 23.3 0.0 0.00068 19.9 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS_2 PF08446.11 CDW53249.1 - 0.017 15.8 0.0 0.042 14.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold Imm49 PF15575.6 CDW53249.1 - 0.09 12.5 0.0 0.48 10.2 0.0 1.9 1 1 1 2 2 2 0 Immunity protein 49 Innexin PF00876.18 CDW53250.1 - 1.5e-243 807.2 35.4 2.8e-128 428.1 10.2 2.0 2 0 0 2 2 2 2 Innexin CHB_HEX_C PF03174.13 CDW53250.1 - 0.21 11.6 0.0 3.5 7.7 0.0 2.3 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain An_peroxidase PF03098.15 CDW53250.1 - 0.23 10.0 0.6 9.9 4.6 0.0 2.2 2 0 0 2 2 2 0 Animal haem peroxidase Y_phosphatase PF00102.27 CDW53251.1 - 1e-73 247.8 1.0 1.3e-73 247.4 0.1 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase FERM_C PF09380.10 CDW53251.1 - 1.6e-19 70.0 0.6 4.5e-19 68.6 0.6 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 CDW53251.1 - 3.4e-18 65.3 0.0 6.4e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain PDZ PF00595.24 CDW53251.1 - 3.8e-18 65.6 0.0 6.7e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain FERM_M PF00373.18 CDW53251.1 - 3.6e-12 46.7 0.1 9.9e-12 45.3 0.1 1.7 1 0 0 1 1 1 1 FERM central domain FA PF08736.11 CDW53251.1 - 1.2e-11 44.5 1.5 2.9e-11 43.3 1.5 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) PDZ_6 PF17820.1 CDW53251.1 - 2.8e-06 27.1 0.0 6.1e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DSPc PF00782.20 CDW53251.1 - 0.00081 19.2 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CDW53251.1 - 0.0015 18.6 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PDZ_2 PF13180.6 CDW53251.1 - 0.096 13.0 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 PDZ domain RED_N PF07808.13 CDW53252.1 - 4.1e-72 242.6 9.4 4.1e-72 242.6 9.4 2.1 2 0 0 2 2 2 1 RED-like protein N-terminal region RED_C PF07807.11 CDW53252.1 - 1.6e-23 83.3 4.0 1.3e-15 57.8 0.7 3.9 4 0 0 4 4 4 2 RED-like protein C-terminal region Lsm_interact PF05391.11 CDW53252.1 - 0.025 14.0 0.0 0.064 12.8 0.0 1.7 1 0 0 1 1 1 0 Lsm interaction motif KBP_C PF12309.8 CDW53252.1 - 0.13 11.7 5.0 0.022 14.3 1.0 1.8 2 0 0 2 2 2 0 KIF-1 binding protein C terminal Presenilin PF01080.17 CDW53252.1 - 3.3 6.4 12.1 0.071 11.9 5.0 1.7 2 0 0 2 2 2 0 Presenilin Bestrophin PF01062.21 CDW53253.1 - 1.6e-101 339.6 8.7 2.6e-101 338.9 8.7 1.3 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel eRF1_1 PF03463.15 CDW53253.1 - 6.1e-54 181.5 0.2 1e-53 180.7 0.2 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 CDW53253.1 - 5.1e-29 101.3 0.1 2.7e-28 98.9 0.0 2.2 3 0 0 3 3 3 1 eRF1 domain 2 eRF1_3 PF03465.15 CDW53253.1 - 6.8e-24 84.5 0.0 1.3e-23 83.6 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 WD40 PF00400.32 CDW53253.1 - 4.3e-12 46.3 4.4 7.6e-08 32.9 0.1 5.3 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53253.1 - 0.0032 17.7 0.0 0.77 10.1 0.0 3.1 2 2 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Patched PF02460.18 CDW53254.1 - 4e-216 719.8 8.5 5.5e-216 719.4 8.5 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW53254.1 - 9.2e-35 119.7 4.9 9.2e-35 119.7 4.9 3.0 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 CDW53254.1 - 1.5 6.4 10.3 2.4 5.7 10.3 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Pkinase PF00069.25 CDW53255.1 - 1.8e-17 63.6 0.0 2.2e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53255.1 - 6.7e-05 22.3 0.0 8.1e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF5623 PF18536.1 CDW53255.1 - 0.1 12.9 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5623) Mannosyl_trans2 PF04188.13 CDW53256.1 - 6.8e-53 180.5 43.7 1.1e-50 173.3 43.7 2.9 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) Lig_chan PF00060.26 CDW53257.1 - 1.5e-14 54.1 3.0 2.5e-14 53.4 3.0 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 CDW53257.1 - 9.7e-12 45.1 0.0 1.7e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 CDW53257.1 - 4.8e-10 39.3 0.0 8.8e-10 38.4 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Acyltransferase PF01553.21 CDW53258.1 - 2.1e-18 66.3 0.0 4.7e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Exo_endo_phos PF03372.23 CDW53259.1 - 0.0012 18.5 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family I-set PF07679.16 CDW53260.1 - 2.1e-44 149.5 0.1 5.9e-15 55.1 0.0 3.6 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW53260.1 - 1.8e-38 131.0 0.8 3.6e-13 49.9 0.0 4.9 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 CDW53260.1 - 1.8e-32 111.5 1.3 2.8e-11 43.6 0.0 4.4 4 1 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 CDW53260.1 - 1.4e-30 105.3 1.6 9.1e-09 35.4 0.3 4.1 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 CDW53260.1 - 6.5e-22 77.8 2.8 2.1e-06 27.9 0.2 5.5 3 2 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW53260.1 - 5.6e-08 32.8 0.1 0.019 15.0 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 CDW53260.1 - 0.068 13.2 0.0 4.7 7.4 0.0 3.0 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Arf PF00025.21 CDW53261.1 - 1.2e-63 213.7 0.1 1.4e-63 213.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW53261.1 - 5.9e-14 52.3 0.0 8e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDW53261.1 - 6.2e-13 48.6 2.4 9.9e-09 34.8 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CDW53261.1 - 1.9e-12 47.0 0.0 2.4e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDW53261.1 - 6.9e-12 45.2 0.0 8.2e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 CDW53261.1 - 3.1e-11 43.1 0.0 3.6e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CDW53261.1 - 2e-08 34.3 0.0 2.9e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 CDW53261.1 - 0.0028 16.7 0.7 0.66 8.9 0.1 2.6 2 1 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 CDW53261.1 - 0.0089 15.6 0.1 0.74 9.4 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CDW53261.1 - 0.013 16.0 0.1 0.032 14.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 CDW53261.1 - 0.034 13.9 0.0 0.07 12.9 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 CDW53261.1 - 0.043 14.2 0.0 0.063 13.7 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 CDW53261.1 - 0.062 12.8 1.2 0.94 9.0 1.2 2.4 1 1 0 1 1 1 0 Ferrous iron transport protein B MAM PF00629.23 CDW53262.1 - 1.6e-06 28.1 5.6 0.015 15.2 0.1 3.9 2 2 0 2 2 2 2 MAM domain, meprin/A5/mu MAM PF00629.23 CDW53264.1 - 0.064 13.2 0.1 0.37 10.7 0.1 2.0 1 1 0 1 1 1 0 MAM domain, meprin/A5/mu I-set PF07679.16 CDW53265.1 - 2.1e-77 255.3 0.0 3.5e-17 62.3 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW53265.1 - 4.8e-74 245.0 0.7 5.2e-17 62.2 0.1 5.7 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 CDW53265.1 - 7e-49 163.9 0.0 4.7e-11 42.7 0.0 5.7 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 CDW53265.1 - 2.8e-45 152.5 0.0 9.8e-12 45.0 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain fn3 PF00041.21 CDW53265.1 - 1.7e-32 111.6 6.4 7e-14 51.9 0.1 3.5 3 0 0 3 3 3 3 Fibronectin type III domain V-set PF07686.17 CDW53265.1 - 6.1e-31 106.8 1.3 1.7e-05 25.0 0.0 8.8 5 4 0 6 6 6 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW53265.1 - 1.8e-11 43.9 0.0 0.041 13.9 0.0 4.9 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 CDW53265.1 - 2.1e-09 36.8 0.0 0.028 14.0 0.0 5.2 5 0 0 5 5 5 2 Immunoglobulin domain Ig_5 PF16681.5 CDW53265.1 - 2.2e-08 34.4 0.0 4.8 7.7 0.0 5.6 6 0 0 6 6 6 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 CDW53265.1 - 7.1e-07 29.4 0.1 12 6.3 0.0 5.8 5 1 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 CDW53265.1 - 4.2e-06 26.7 0.1 5.4 7.2 0.0 5.4 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 CDW53265.1 - 0.0001 22.3 0.2 7.3 6.7 0.0 5.5 7 0 0 7 7 6 1 C17orf99 Ig domain PTP_tm PF18861.1 CDW53265.1 - 0.051 13.6 0.2 0.55 10.2 0.1 2.4 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF2369 PF10179.9 CDW53265.1 - 0.077 13.4 0.0 14 6.2 0.0 4.0 5 0 0 5 5 5 0 Uncharacterised conserved protein (DUF2369) C2-set PF05790.15 CDW53265.1 - 0.089 13.0 0.0 56 4.0 0.0 4.3 4 1 1 5 5 5 0 Immunoglobulin C2-set domain 7TM_GPCR_Srw PF10324.9 CDW53267.1 - 1.3e-15 57.6 16.7 2.1e-15 56.8 16.7 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW53267.1 - 7.9e-14 51.6 17.9 2.1e-13 50.2 17.9 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5635 PF18685.1 CDW53267.1 - 0.024 14.6 0.2 0.071 13.1 0.2 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5635) TRAP_alpha PF03896.16 CDW53268.1 - 0.0083 15.4 0.2 0.0098 15.1 0.2 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit CENP-B_dimeris PF09026.10 CDW53268.1 - 0.012 16.0 2.9 0.013 15.8 2.9 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain dsRBD2 PF17842.1 CDW53268.1 - 0.16 12.1 0.5 0.2 11.9 0.5 1.1 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 Radial_spoke PF04712.12 CDW53268.1 - 2.3 7.1 12.3 2.5 6.9 12.3 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein COPI_assoc PF08507.10 CDW53269.1 - 0.0031 17.5 0.6 0.0036 17.4 0.6 1.1 1 0 0 1 1 1 1 COPI associated protein TMEM72 PF16054.5 CDW53269.1 - 0.058 13.1 0.0 0.066 12.9 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein family 72 DUF2244 PF10003.9 CDW53269.1 - 1.3 8.7 2.7 1.8 8.3 2.7 1.1 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) DUF1180 PF06679.12 CDW53270.1 - 0.0085 16.5 0.1 0.011 16.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) NCU-G1 PF15065.6 CDW53270.1 - 0.059 12.3 0.1 0.09 11.8 0.1 1.2 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 Myc_target_1 PF15179.6 CDW53270.1 - 3.9 7.3 5.6 1.7 8.5 2.1 1.9 1 1 1 2 2 2 0 Myc target protein 1 WD40 PF00400.32 CDW53271.1 - 1e-13 51.5 14.2 0.00018 22.2 0.2 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 CDW53271.1 - 1.6e-09 37.9 0.1 2.5e-08 34.1 0.0 2.8 2 1 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 CDW53271.1 - 0.00011 22.4 3.1 0.39 11.0 0.0 3.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ets PF00178.22 CDW53271.1 - 0.069 13.6 0.4 5.6 7.5 0.0 2.4 2 0 0 2 2 2 0 Ets-domain Astacin PF01400.24 CDW53272.1 - 4.3e-69 232.0 0.1 6.1e-69 231.5 0.1 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 CDW53272.1 - 4.2e-13 49.6 0.0 8.7e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 CUB domain TSP_1 PF00090.19 CDW53272.1 - 2.3e-08 34.1 15.7 2.3e-08 34.1 15.7 2.5 2 0 0 2 2 2 1 Thrombospondin type 1 domain Peptidase_M10 PF00413.24 CDW53272.1 - 0.0005 19.9 0.0 0.67 9.8 0.0 2.3 2 0 0 2 2 2 2 Matrixin DNMT1-RFD PF12047.8 CDW53272.1 - 0.092 12.8 0.2 8.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain CUB_2 PF02408.20 CDW53272.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 CUB-like domain DUF4853 PF16145.5 CDW53272.1 - 0.16 12.1 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) BCL_N PF04714.13 CDW53273.1 - 1.4e-25 89.1 11.8 2.1e-25 88.5 11.8 1.3 1 0 0 1 1 1 1 BCL7, N-terminal conserver region PQ-loop PF04193.14 CDW53274.1 - 2.5e-33 113.6 13.2 7.2e-19 67.3 2.9 2.5 2 0 0 2 2 2 2 PQ loop repeat DUF1689 PF07954.11 CDW53274.1 - 0.022 15.2 0.4 0.75 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1689) ER_lumen_recept PF00810.18 CDW53274.1 - 0.055 14.3 0.1 0.055 14.3 0.1 2.5 1 1 1 2 2 2 0 ER lumen protein retaining receptor MtN3_slv PF03083.16 CDW53274.1 - 0.73 9.9 6.4 14 5.8 0.1 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange ATP-synt_ab PF00006.25 CDW53275.1 - 4.4e-63 212.8 0.0 6e-63 212.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDW53275.1 - 3e-23 82.1 2.0 6.8e-23 81.0 2.0 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase_2 PF01637.18 CDW53275.1 - 0.009 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 CDW53275.1 - 0.0091 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase NB-ARC PF00931.22 CDW53275.1 - 0.017 14.3 0.1 0.034 13.3 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.29 CDW53275.1 - 0.05 14.0 0.1 0.37 11.2 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CDW53275.1 - 0.12 12.7 0.7 0.3 11.4 0.3 1.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CDW53275.1 - 0.2 11.5 0.1 0.52 10.2 0.0 1.7 2 0 0 2 2 2 0 NACHT domain Alg6_Alg8 PF03155.15 CDW53276.1 - 2.1e-105 353.5 35.2 7e-67 226.4 15.1 2.9 1 1 1 2 2 2 2 ALG6, ALG8 glycosyltransferase family MMR_HSR1 PF01926.23 CDW53277.1 - 6.4e-08 32.7 0.0 2.7e-07 30.7 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDW53277.1 - 0.00023 20.8 0.0 0.0013 18.3 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CDW53277.1 - 0.00047 19.7 0.2 0.88 9.1 0.1 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B PduV-EutP PF10662.9 CDW53277.1 - 0.001 18.8 0.5 1.1 9.0 0.1 2.3 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 CDW53277.1 - 0.0028 18.1 0.0 0.015 15.6 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 CDW53277.1 - 0.0051 16.9 0.0 0.023 14.7 0.0 2.0 1 1 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 CDW53277.1 - 0.014 15.7 0.2 0.031 14.5 0.2 1.6 1 0 0 1 1 1 0 AAA domain Oxidoreduct_C PF16490.5 CDW53277.1 - 0.017 14.8 0.0 0.026 14.3 0.0 1.2 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain Arf PF00025.21 CDW53277.1 - 0.019 14.4 0.6 1.4 8.4 0.1 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_18 PF13238.6 CDW53277.1 - 0.026 15.1 0.1 0.061 13.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 CDW53277.1 - 0.034 13.5 0.1 0.095 12.0 0.0 1.7 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA PF00004.29 CDW53277.1 - 0.043 14.2 0.1 0.12 12.8 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRPRB PF09439.10 CDW53277.1 - 0.05 13.0 0.3 0.21 11.0 0.1 2.1 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit EHD_N PF16880.5 CDW53277.1 - 0.054 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 N-terminal EH-domain containing protein cobW PF02492.19 CDW53277.1 - 0.054 13.1 0.8 5.2 6.6 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDW53277.1 - 0.12 12.5 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 CDW53277.1 - 0.3 10.8 1.5 7.7 6.2 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Rab5-bind PF09311.11 CDW53278.1 - 1.8e-82 277.2 56.1 2.1e-82 277.0 56.1 1.0 1 0 0 1 1 1 1 Rabaptin-like protein FYVE PF01363.21 CDW53278.1 - 9e-14 51.4 12.5 9e-14 51.4 12.5 2.7 2 1 0 2 2 2 1 FYVE zinc finger ADK_lid PF05191.14 CDW53278.1 - 0.052 13.5 2.4 4.4 7.4 2.4 2.6 1 1 0 1 1 1 0 Adenylate kinase, active site lid Trm112p PF03966.16 CDW53278.1 - 0.055 14.1 0.3 0.055 14.1 0.3 3.9 2 2 1 3 3 3 0 Trm112p-like protein IBR PF01485.21 CDW53278.1 - 0.16 12.2 8.7 0.16 12.2 6.4 2.3 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain IclR PF01614.18 CDW53278.1 - 0.4 10.5 3.9 0.55 10.1 0.5 2.7 1 1 1 2 2 2 0 Bacterial transcriptional regulator Ribosomal_S27e PF01667.17 CDW53278.1 - 0.83 9.4 9.7 0.4 10.4 3.6 3.1 2 1 1 3 3 3 0 Ribosomal protein S27 HMMR_N PF15905.5 CDW53278.1 - 1.6 8.2 50.6 1.7 8.1 26.4 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal CK_II_beta PF01214.18 CDW53278.1 - 2.5 7.9 7.0 0.16 11.8 1.8 1.7 2 0 0 2 2 2 0 Casein kinase II regulatory subunit zf-RING_2 PF13639.6 CDW53278.1 - 7.2 7.0 11.9 23 5.4 11.9 2.0 1 0 0 1 1 1 0 Ring finger domain zf-AN1 PF01428.16 CDW53278.1 - 8 6.7 13.1 2 8.6 8.9 2.2 2 1 1 3 3 2 0 AN1-like Zinc finger DUF1768 PF08719.11 CDW53279.1 - 1.8e-23 83.5 0.0 1.2e-06 28.8 0.0 3.9 3 2 0 3 3 3 3 Domain of unknown function (DUF1768) 2-Hacid_dh_C PF02826.19 CDW53280.1 - 1.8e-59 200.1 0.0 2.9e-59 199.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDW53280.1 - 1.1e-31 109.3 0.1 1.3e-31 109.0 0.1 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CDW53280.1 - 0.00029 21.1 0.0 0.00072 19.8 0.0 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 CDW53280.1 - 0.023 15.0 0.1 1.9 8.8 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain PTS_IIB PF02302.17 CDW53280.1 - 0.094 13.4 0.3 0.35 11.6 0.2 2.0 1 1 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIB subunit PhoLip_ATPase_C PF16212.5 CDW53281.1 - 2.6e-62 210.8 22.0 2.6e-62 210.8 22.0 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDW53281.1 - 2.7e-24 84.6 1.9 7.9e-24 83.1 1.9 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CDW53281.1 - 2.6e-13 50.7 0.0 6.8e-06 26.5 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDW53281.1 - 1.3e-08 34.8 0.0 2.9e-07 30.5 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDW53281.1 - 6.4e-06 25.8 0.4 2.7e-05 23.7 0.0 2.2 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDW53281.1 - 0.0031 17.3 0.0 0.0098 15.7 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW53281.1 - 0.0061 17.0 0.0 4.7 7.6 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase LIM PF00412.22 CDW53282.1 - 1.2e-06 28.6 6.6 9.1e-06 25.8 6.6 2.2 1 1 0 1 1 1 1 LIM domain PDZ_6 PF17820.1 CDW53282.1 - 4.1e-06 26.5 0.0 8.1e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW53282.1 - 0.0076 16.6 0.0 0.028 14.8 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Desulfoferrod_N PF06397.12 CDW53282.1 - 0.048 13.3 3.7 2.5 7.8 1.4 2.5 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Ald_deCOase PF11266.8 CDW53282.1 - 0.065 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Long-chain fatty aldehyde decarbonylase PDZ_2 PF13180.6 CDW53282.1 - 0.068 13.5 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 PDZ domain Zn_ribbon_2 PF12674.7 CDW53282.1 - 0.13 12.9 1.6 0.21 12.2 0.3 2.0 2 0 0 2 2 2 0 Putative zinc ribbon domain HypA PF01155.19 CDW53282.1 - 0.74 9.8 4.6 4 7.5 4.6 2.4 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Patched PF02460.18 CDW53283.1 - 1.5e-07 30.0 12.9 2e-07 29.5 12.9 1.1 1 0 0 1 1 1 1 Patched family MMPL PF03176.15 CDW53283.1 - 0.026 13.5 0.5 0.045 12.7 0.5 1.4 1 0 0 1 1 1 0 MMPL family Peptidase_M17 PF00883.21 CDW53284.1 - 8.4e-113 376.7 0.0 1.1e-112 376.4 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDW53284.1 - 3.3e-13 49.6 0.1 5.5e-13 48.9 0.1 1.4 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Peptidase_M17 PF00883.21 CDW53285.1 - 2.8e-115 384.9 0.0 5e-115 384.1 0.0 1.4 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDW53285.1 - 1e-15 57.7 0.5 1.7e-15 57.0 0.5 1.3 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain DUF3858 PF12970.7 CDW53285.1 - 0.23 11.5 0.0 0.42 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3858) Alpha-amylase_C PF02806.18 CDW53286.1 - 1.9e-21 76.4 0.0 5.1e-21 75.0 0.0 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 CDW53286.1 - 3.7e-13 49.6 0.1 1e-12 48.2 0.1 1.8 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 CDW53286.1 - 2.1e-11 44.0 0.2 3.5e-07 30.1 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Aminotran_1_2 PF00155.21 CDW53286.1 - 0.051 12.7 0.0 0.076 12.2 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class I and II Ribosomal_L31e PF01198.19 CDW53287.1 - 2e-46 156.1 0.9 2.7e-46 155.7 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.15 CDW53287.1 - 0.011 15.5 0.6 0.03 14.2 0.2 1.9 1 1 1 2 2 2 0 DNA mismatch endonuclease Vsr VWA PF00092.28 CDW53288.1 - 1.6e-29 103.4 3.0 2.7e-29 102.6 3.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CDW53288.1 - 5.3e-11 43.1 1.4 7.3e-11 42.7 0.3 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain Zona_pellucida PF00100.23 CDW53288.1 - 5e-10 39.6 1.9 1.2e-09 38.3 1.9 1.6 1 1 0 1 1 1 1 Zona pellucida-like domain HRM PF02793.22 CDW53289.1 - 8.3e-07 29.2 0.8 1.6e-06 28.3 0.8 1.6 1 0 0 1 1 1 1 Hormone receptor domain ADD_DNMT3 PF17980.1 CDW53289.1 - 0.022 14.8 0.4 3.5 7.7 0.1 2.4 1 1 1 2 2 2 0 Cysteine rich ADD domain in DNMT3 7tm_2 PF00002.24 CDW53291.1 - 1.2e-37 129.6 19.2 1.8e-37 129.0 19.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) ASXH PF13919.6 CDW53292.1 - 0.00012 22.2 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 Asx homology domain Glyco_hydro_31 PF01055.26 CDW53293.1 - 9.6e-145 483.1 3.0 1.2e-144 482.8 3.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CDW53293.1 - 8.3e-21 74.3 0.0 1.6e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CDW53293.1 - 1.2e-08 35.1 0.7 4.2e-08 33.4 0.7 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like Ig_2 PF13895.6 CDW53294.1 - 3e-06 27.5 1.0 2.1e-05 24.8 0.1 2.4 2 0 0 2 2 2 1 Immunoglobulin domain TB2_DP1_HVA22 PF03134.19 CDW53294.1 - 2.6e-05 24.1 0.7 2.6e-05 24.1 0.7 1.7 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Ig_3 PF13927.6 CDW53294.1 - 0.004 17.7 0.4 0.018 15.6 0.1 2.2 3 0 0 3 3 3 1 Immunoglobulin domain Renin_r PF07850.14 CDW53294.1 - 0.27 11.9 1.4 0.39 11.3 0.0 2.1 2 0 0 2 2 2 0 Renin receptor-like protein DNA_pol_B PF00136.21 CDW53295.1 - 1.1e-109 367.2 0.9 4.8e-109 365.1 0.9 1.8 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CDW53295.1 - 9.6e-11 41.4 0.0 1.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 CDW53295.1 - 2.1e-08 34.1 0.5 4.4e-08 33.1 0.5 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_2 PF03175.13 CDW53295.1 - 0.00015 20.7 0.0 0.00025 20.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral SRP40_C PF05022.12 CDW53295.1 - 0.025 15.4 2.0 0.062 14.1 2.0 1.6 1 0 0 1 1 1 0 SRP40, C-terminal domain DUF1744 PF08490.12 CDW53295.1 - 0.054 12.1 0.1 0.081 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) KTI12 PF08433.10 CDW53296.1 - 1.8e-55 188.3 0.0 2.1e-55 188.1 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 CDW53296.1 - 5.4e-09 36.4 0.0 1.3e-08 35.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDW53296.1 - 0.0052 17.3 0.0 0.01 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDW53296.1 - 0.036 14.3 0.0 0.079 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CDW53296.1 - 0.068 13.1 0.0 0.085 12.8 0.0 1.4 1 1 0 1 1 1 0 Adenylylsulphate kinase AAA_16 PF13191.6 CDW53296.1 - 0.095 13.1 0.0 0.16 12.4 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 CDW53296.1 - 0.1 11.9 0.0 0.23 10.7 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin 7tm_1 PF00001.21 CDW53297.1 - 2e-12 47.0 14.5 2e-12 47.0 14.5 1.7 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW53297.1 - 9e-06 25.5 14.0 2.4e-05 24.1 13.8 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF1616 PF07760.11 CDW53297.1 - 0.004 16.6 1.0 0.0076 15.7 1.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1616) DUF5084 PF16894.5 CDW53297.1 - 0.083 13.3 0.3 0.083 13.3 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5084) Peptidase_M8 PF01457.16 CDW53299.1 - 7.3e-47 160.2 0.5 1e-46 159.8 0.5 1.1 1 0 0 1 1 1 1 Leishmanolysin zf-H2C2_2 PF13465.6 CDW53300.1 - 1.2e-30 104.5 33.7 3.2e-09 36.8 0.7 5.6 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 CDW53300.1 - 3.5e-19 68.1 38.6 3.4e-06 27.2 0.7 6.6 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW53300.1 - 1.2e-12 47.6 32.4 0.0024 18.6 0.5 6.2 5 0 0 5 5 5 4 C2H2-type zinc finger zf-met PF12874.7 CDW53300.1 - 8.2e-09 35.6 19.1 0.0049 17.2 0.7 5.4 5 0 0 5 5 4 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW53300.1 - 1.9e-08 34.4 8.5 0.027 14.8 0.0 5.0 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW53300.1 - 1.1e-07 31.7 28.6 0.00034 20.5 0.3 5.0 5 0 0 5 5 4 3 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 CDW53300.1 - 0.016 15.3 13.4 0.49 10.5 1.7 4.2 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2HE PF16278.5 CDW53300.1 - 0.021 15.2 31.0 0.029 14.8 0.2 5.4 3 1 4 7 7 5 0 C2HE / C2H2 / C2HC zinc-binding finger SET PF00856.28 CDW53300.1 - 0.039 14.3 0.0 0.4 11.1 0.0 2.2 2 0 0 2 2 2 0 SET domain zf_UBZ PF18439.1 CDW53300.1 - 0.094 12.3 10.1 4.4 7.0 0.2 4.4 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2H2_2 PF12756.7 CDW53300.1 - 0.23 11.8 17.1 11 6.5 0.3 4.6 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF678 PF05077.12 CDW53300.1 - 0.31 11.2 2.9 3.7 7.8 0.2 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF678) C1_4 PF07975.12 CDW53300.1 - 0.33 11.2 17.4 1.7 8.9 0.1 4.1 2 1 0 3 3 3 0 TFIIH C1-like domain zf-HYPF PF07503.12 CDW53300.1 - 0.35 10.7 0.1 0.35 10.7 0.1 3.0 4 0 0 4 4 2 0 HypF finger DUF4428 PF14471.6 CDW53300.1 - 3 7.9 7.6 0.43 10.6 0.2 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4428) zf-AN1 PF01428.16 CDW53300.1 - 5.3 7.3 16.8 7.7 6.8 0.1 5.3 5 0 0 5 5 5 0 AN1-like Zinc finger zinc_ribbon_15 PF17032.5 CDW53300.1 - 6.6 7.6 14.8 4.7 8.0 1.2 4.2 2 1 0 3 3 3 0 zinc-ribbon family zf-MYST PF17772.1 CDW53300.1 - 8.7 6.0 12.2 6.5 6.4 0.1 4.9 3 1 2 5 5 5 0 MYST family zinc finger domain fn3 PF00041.21 CDW53301.1 - 3.7e-15 56.0 0.2 1.3e-05 25.5 0.0 5.3 5 1 0 5 5 5 3 Fibronectin type III domain C2 PF00168.30 CDW53302.1 - 7.1e-42 141.9 0.1 5.5e-20 71.6 0.0 2.3 2 0 0 2 2 2 2 C2 domain EphA2_TM PF14575.6 CDW53302.1 - 0.079 13.8 0.0 0.19 12.6 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Cyclin_N PF00134.23 CDW53302.1 - 0.089 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Cyclin, N-terminal domain SRF-TF PF00319.18 CDW53304.1 - 4.2e-25 87.0 0.4 1e-24 85.8 0.4 1.7 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) GHD PF17834.1 CDW53304.1 - 0.022 14.8 0.1 0.051 13.6 0.1 1.6 1 0 0 1 1 1 0 Beta-sandwich domain in beta galactosidase MRP-L20 PF12824.7 CDW53304.1 - 0.51 10.5 1.9 1 9.5 1.9 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 PsbJ PF01788.17 CDW53305.1 - 0.0013 18.6 0.2 0.0028 17.5 0.2 1.5 1 0 0 1 1 1 1 PsbJ FxsA PF04186.13 CDW53305.1 - 0.051 13.7 0.1 1 9.5 0.0 2.2 2 0 0 2 2 2 0 FxsA cytoplasmic membrane protein TSP_1 PF00090.19 CDW53306.1 - 1.3e-30 105.4 113.0 3.8e-06 27.0 2.0 12.8 12 2 0 12 12 12 9 Thrombospondin type 1 domain I-set PF07679.16 CDW53306.1 - 3.7e-09 36.5 0.0 1.4e-08 34.7 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW53306.1 - 2.8e-07 31.0 3.3 4.4e-07 30.4 0.0 3.1 4 0 0 4 4 4 1 Immunoglobulin domain Ig_2 PF13895.6 CDW53306.1 - 2.3e-06 27.8 0.0 1.9e-05 24.9 0.0 2.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 CDW53306.1 - 6.5e-06 26.2 4.4 4.2e-05 23.6 0.0 3.7 4 0 0 4 4 4 1 Immunoglobulin domain V-set PF07686.17 CDW53306.1 - 0.00038 20.6 0.4 0.0031 17.7 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_6 PF18452.1 CDW53306.1 - 0.0042 16.6 0.0 0.015 14.8 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain vWF_A PF12450.8 CDW53307.1 - 0.25 11.3 1.3 0.65 10.0 0.0 2.3 3 0 0 3 3 3 0 von Willebrand factor adh_short PF00106.25 CDW53308.1 - 4.7e-33 114.3 0.1 8.6e-33 113.4 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW53308.1 - 5.3e-30 104.7 0.2 7.8e-30 104.2 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 CDW53308.1 - 2.3e-15 56.9 0.0 4.5e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 CDW53308.1 - 8.6e-05 22.5 0.1 0.00014 21.9 0.1 1.3 1 0 0 1 1 1 1 KR domain Alkyl_sulf_C PF14864.6 CDW53308.1 - 0.009 16.3 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal HCO3_cotransp PF00955.21 CDW53309.1 - 1.8e-96 324.0 10.8 2.6e-94 316.9 3.1 2.0 1 1 1 2 2 2 2 HCO3- transporter family MFS_MOT1 PF16983.5 CDW53309.1 - 0.46 10.9 5.0 6.7 7.2 0.2 2.8 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily RCC1 PF00415.18 CDW53310.1 - 4.9e-41 139.1 5.3 1.4e-07 32.1 0.0 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDW53310.1 - 9.8e-17 60.3 29.2 9e-07 28.5 1.5 6.7 8 0 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat Laminin_G_2 PF02210.24 CDW53311.1 - 2.4e-45 154.2 0.1 3e-22 79.6 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 CDW53311.1 - 6.4e-43 146.1 0.0 4.5e-20 72.2 0.0 2.1 2 0 0 2 2 2 2 Laminin G domain Laminin_EGF PF00053.24 CDW53312.1 - 5.7e-144 468.2 430.4 2e-10 40.6 12.3 24.7 21 5 3 24 24 24 23 Laminin EGF domain Laminin_N PF00055.17 CDW53312.1 - 1.8e-67 227.4 0.0 1.8e-67 227.4 0.0 4.1 4 0 0 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 CDW53312.1 - 2e-10 40.7 0.2 3.4e-09 36.7 0.0 2.3 1 1 1 2 2 2 1 Laminin B (Domain IV) DALR_1 PF05746.15 CDW53313.1 - 9.2e-06 25.8 0.0 2.5e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain FMN_red PF03358.15 CDW53313.1 - 0.033 13.9 0.0 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 NADPH-dependent FMN reductase Mob1_phocein PF03637.17 CDW53314.1 - 2.9e-71 238.9 0.0 3.5e-71 238.7 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family UBX PF00789.20 CDW53315.1 - 3.7e-05 23.8 0.0 0.00014 22.0 0.0 1.9 2 0 0 2 2 2 1 UBX domain Baculo_VP39 PF04501.12 CDW53315.1 - 0.14 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Baculovirus major capsid protein VP39 Rad51 PF08423.11 CDW53316.1 - 4.5e-130 432.4 0.0 6e-130 432.0 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 CDW53316.1 - 6.6e-10 38.9 0.0 9.6e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 CDW53316.1 - 2.8e-09 36.8 0.1 6.7e-09 35.6 0.1 1.5 1 1 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 CDW53316.1 - 8.5e-06 26.3 0.1 2e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 CDW53316.1 - 2.2e-05 23.9 0.8 0.00027 20.4 0.3 2.1 2 0 0 2 2 2 1 KaiC AAA_24 PF13479.6 CDW53316.1 - 0.042 13.6 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 CDW53317.1 - 2.7e-74 249.8 0.0 4e-74 249.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53317.1 - 1.1e-45 155.9 0.0 1.7e-45 155.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 CDW53317.1 - 1.1e-19 69.9 0.1 2.5e-19 68.8 0.1 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 CDW53317.1 - 1.1e-06 28.2 0.0 1.8e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDW53317.1 - 0.00011 21.6 0.1 0.00019 20.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDW53317.1 - 0.0011 18.7 0.2 0.0023 17.5 0.2 1.5 1 0 0 1 1 1 1 RIO1 family PGC7_Stella PF15549.6 CDW53317.1 - 0.0017 18.3 0.0 0.0042 17.1 0.0 1.6 1 0 0 1 1 1 1 PGC7/Stella/Dppa3 domain UBA PF00627.31 CDW53317.1 - 0.023 14.6 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 UBA/TS-N domain UBA_2 PF08587.11 CDW53317.1 - 0.072 13.2 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Pkinase_fungal PF17667.1 CDW53317.1 - 0.092 11.5 0.1 0.31 9.8 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase MAM PF00629.23 CDW53318.1 - 2e-22 79.9 0.0 4.6e-12 46.1 0.0 2.3 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu SNAP PF14938.6 CDW53319.1 - 1.6e-94 316.5 28.9 7.6e-93 311.0 28.9 2.0 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 CDW53319.1 - 5.2e-06 26.7 4.2 0.0019 18.4 0.2 3.4 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW53319.1 - 0.00013 21.8 18.5 1.4 9.2 0.1 7.0 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDW53319.1 - 0.0004 20.2 8.0 3.7 7.8 0.1 5.3 3 1 2 5 5 5 2 Tetratricopeptide repeat NSF PF02071.20 CDW53319.1 - 0.0034 17.8 25.7 5.3 8.3 0.2 8.0 8 0 0 8 8 8 1 Aromatic-di-Alanine (AdAR) repeat RPN7 PF10602.9 CDW53319.1 - 0.029 14.1 4.2 0.092 12.5 4.2 2.0 1 1 0 1 1 1 0 26S proteasome subunit RPN7 Sel1 PF08238.12 CDW53319.1 - 0.048 14.4 4.8 1.1 10.0 0.2 4.2 5 0 0 5 5 5 0 Sel1 repeat TPR_8 PF13181.6 CDW53319.1 - 0.083 13.1 21.7 0.96 9.8 0.1 6.3 4 3 3 7 7 7 0 Tetratricopeptide repeat Spatacsin_C PF14649.6 CDW53319.1 - 0.12 11.5 10.9 0.048 12.8 5.6 2.7 2 1 1 3 3 3 0 Spatacsin C-terminus TPR_1 PF00515.28 CDW53319.1 - 0.13 12.1 0.1 0.13 12.1 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4368 PF14287.6 CDW53319.1 - 0.47 10.8 2.1 1.5 9.2 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4368) TPR_6 PF13174.6 CDW53319.1 - 0.85 10.4 11.2 23 5.9 0.0 5.6 5 1 2 7 7 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW53319.1 - 7.6 6.8 15.3 47 4.3 6.5 3.8 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 7tm_1 PF00001.21 CDW53320.1 - 0.0027 17.1 17.7 0.0042 16.4 17.4 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF3974 PF13120.6 CDW53320.1 - 0.4 10.8 0.1 0.4 10.8 0.1 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3974) SIT PF15330.6 CDW53320.1 - 2.3 8.7 4.2 0.58 10.6 0.2 2.0 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT RNase_PH PF01138.21 CDW53321.1 - 1.1e-24 87.5 0.0 1.6e-24 86.9 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 TPR_12 PF13424.6 CDW53322.1 - 1.6e-73 242.9 29.0 1e-20 73.8 2.3 5.7 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 CDW53322.1 - 9e-60 197.1 24.1 3.7e-16 58.4 0.0 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 CDW53322.1 - 1.5e-33 112.3 13.3 5.8e-06 26.0 0.0 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 CDW53322.1 - 9.1e-30 101.2 30.4 1.2e-07 31.2 0.5 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 CDW53322.1 - 8.9e-22 75.4 29.9 0.00057 19.8 0.7 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDW53322.1 - 9.9e-18 62.8 26.4 0.0013 18.8 0.1 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW53322.1 - 2.8e-15 56.6 0.9 2.8e-15 56.6 0.9 3.3 3 1 0 3 3 2 1 MalT-like TPR region TPR_16 PF13432.6 CDW53322.1 - 1.5e-14 54.3 7.3 0.0018 18.9 0.1 5.5 3 2 1 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDW53322.1 - 2.7e-12 47.0 15.8 1.8e-05 25.2 0.2 4.9 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 CDW53322.1 - 7.2e-11 41.7 12.1 0.052 13.9 0.5 6.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW53322.1 - 8e-11 41.8 11.4 0.45 11.5 0.0 6.9 4 1 3 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW53322.1 - 9.4e-09 35.4 12.6 0.00081 19.6 2.9 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 CDW53322.1 - 2.3e-08 33.9 0.0 9.7 7.2 0.0 6.4 7 0 0 7 7 5 0 Tetratricopeptide repeat PPR PF01535.20 CDW53322.1 - 7e-06 25.9 1.7 0.035 14.4 0.0 5.1 6 0 0 6 6 4 1 PPR repeat NUDE_C PF04880.13 CDW53322.1 - 5.1e-05 23.8 0.9 0.00011 22.7 0.9 1.5 1 0 0 1 1 1 1 NUDE protein, C-terminal conserved region PPR_2 PF13041.6 CDW53322.1 - 0.0019 18.4 0.5 0.73 10.1 0.0 3.4 3 0 0 3 3 3 1 PPR repeat family TPR_11 PF13414.6 CDW53322.1 - 0.002 17.8 23.8 0.0048 16.6 0.9 5.8 6 0 0 6 6 5 2 TPR repeat DUF627 PF04781.12 CDW53322.1 - 0.026 14.5 4.4 2.1 8.4 0.1 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF627) Csm1_N PF18504.1 CDW53322.1 - 0.032 14.6 3.4 0.032 14.6 3.4 2.9 2 0 0 2 2 1 0 Csm1 N-terminal domain L27 PF02828.16 CDW53322.1 - 0.045 13.5 0.0 0.17 11.7 0.0 2.1 1 0 0 1 1 1 0 L27 domain SHNi-TPR PF10516.9 CDW53322.1 - 0.051 13.0 5.3 1.1 8.7 0.2 4.0 4 0 0 4 4 4 0 SHNi-TPR WbqC PF08889.11 CDW53322.1 - 0.13 12.2 3.6 3.3 7.6 0.0 3.5 2 1 1 4 4 4 0 WbqC-like protein family DUF2225 PF09986.9 CDW53322.1 - 0.15 11.7 13.1 0.43 10.3 2.8 3.4 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Wzy_C_2 PF11846.8 CDW53322.1 - 0.16 11.9 3.2 11 5.9 0.0 4.1 3 2 2 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal DUF4919 PF16266.5 CDW53322.1 - 0.17 11.8 5.4 0.23 11.4 0.1 3.3 3 1 1 4 4 3 0 Domain of unknown function (DUF4919) RPN7 PF10602.9 CDW53322.1 - 0.35 10.5 13.6 0.28 10.9 1.1 4.0 3 1 2 5 5 4 0 26S proteasome subunit RPN7 Clathrin PF00637.20 CDW53322.1 - 0.62 9.9 9.0 0.22 11.4 1.0 3.6 2 1 2 4 4 4 0 Region in Clathrin and VPS TPR_20 PF14561.6 CDW53322.1 - 0.71 10.3 12.2 4.5 7.7 1.2 5.0 4 1 0 5 5 3 0 Tetratricopeptide repeat DUF1054 PF06335.12 CDW53322.1 - 1 9.2 7.8 0.64 9.9 3.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1054) TMF_TATA_bd PF12325.8 CDW53322.1 - 1.5 9.1 20.5 0.027 14.7 7.5 3.1 2 1 1 3 3 2 0 TATA element modulatory factor 1 TATA binding JIP_LZII PF16471.5 CDW53322.1 - 2 8.6 12.3 0.19 11.9 5.2 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II COG2 PF06148.11 CDW53322.1 - 4 7.5 9.6 4.1 7.5 2.2 2.8 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_3 PF07720.12 CDW53322.1 - 5.4 7.1 15.1 3.9 7.6 0.6 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF1897 PF09005.10 CDW53322.1 - 6 6.4 7.3 9.4 5.8 0.2 3.4 4 0 0 4 4 3 0 Domain of unknown function (DUF1897) SNARE PF05739.19 CDW53323.1 - 2.7e-15 56.1 0.3 5.4e-15 55.1 0.3 1.5 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 CDW53323.1 - 0.00091 19.0 4.6 0.0024 17.6 4.6 1.7 1 1 0 1 1 1 1 Syntaxin DUF16 PF01519.16 CDW53323.1 - 0.046 14.2 1.7 0.13 12.8 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function DUF16 Helitron_like_N PF14214.6 CDW53323.1 - 0.06 13.6 1.6 0.093 12.9 1.3 1.4 1 1 0 1 1 1 0 Helitron helicase-like domain at N-terminus CHASE3 PF05227.13 CDW53323.1 - 0.27 11.1 3.2 6.6 6.6 0.1 2.3 2 0 0 2 2 2 0 CHASE3 domain SKA1 PF07160.12 CDW53323.1 - 0.37 10.6 4.0 0.38 10.6 0.1 2.1 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 zf-RING_2 PF13639.6 CDW53325.1 - 1.2e-10 41.6 8.4 3.7e-10 40.0 8.4 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDW53325.1 - 6e-08 32.4 7.9 1.6e-07 31.1 7.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDW53325.1 - 1.1e-07 32.0 10.6 5.1e-07 29.9 10.6 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDW53325.1 - 1.1e-07 31.6 7.1 2.9e-07 30.2 7.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW53325.1 - 2e-06 27.7 4.4 5.6e-06 26.3 4.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDW53325.1 - 1.5e-05 24.9 6.6 1.5e-05 24.9 6.6 1.8 2 0 0 2 2 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 CDW53325.1 - 5.9e-05 22.6 3.4 5.9e-05 22.6 3.4 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 CDW53325.1 - 7.5e-05 22.4 4.4 7.5e-05 22.4 4.4 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 CDW53325.1 - 0.00016 21.5 6.3 0.00016 21.5 6.3 2.3 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW53325.1 - 0.00086 19.1 5.1 0.00086 19.1 5.1 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 CDW53325.1 - 0.0066 16.6 1.2 0.017 15.3 1.2 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 CDW53325.1 - 0.018 15.1 4.9 0.064 13.3 4.9 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 CDW53325.1 - 0.023 15.0 6.9 0.044 14.1 6.9 1.5 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.5 CDW53325.1 - 0.14 12.3 3.4 0.27 11.3 2.3 2.1 2 0 0 2 2 2 0 KIAA1045 RING finger Endonuclease_7 PF02945.15 CDW53325.1 - 0.31 11.0 1.4 0.71 9.8 1.4 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII RINGv PF12906.7 CDW53325.1 - 0.37 11.0 7.5 0.97 9.6 7.5 1.8 1 0 0 1 1 1 0 RING-variant domain TAP_C PF03943.13 CDW53326.1 - 2e-17 62.5 0.7 9.3e-17 60.4 0.1 2.4 2 0 0 2 2 2 1 TAP C-terminal domain UBA_4 PF14555.6 CDW53326.1 - 6.9e-05 22.6 0.3 0.0015 18.3 0.1 2.8 3 0 0 3 3 3 1 UBA-like domain Tap-RNA_bind PF09162.10 CDW53326.1 - 7.9e-05 22.4 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Tap, RNA-binding LRR_8 PF13855.6 CDW53326.1 - 0.0026 17.5 1.1 0.015 15.0 0.8 2.4 2 1 0 2 2 2 1 Leucine rich repeat LRR_6 PF13516.6 CDW53326.1 - 0.0039 17.1 0.3 4.5 7.6 0.0 4.0 4 0 0 4 4 4 1 Leucine Rich repeat LRR_4 PF12799.7 CDW53326.1 - 0.0097 16.3 0.2 0.0097 16.3 0.2 3.9 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) NTF2 PF02136.20 CDW53326.1 - 0.011 16.2 0.5 0.046 14.3 0.1 2.2 2 1 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain Mito_carr PF00153.27 CDW53327.1 - 1.9e-43 146.3 3.8 1.2e-18 66.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2569 PF10754.9 CDW53327.1 - 0.02 15.4 0.0 0.052 14.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) ECH_1 PF00378.20 CDW53328.1 - 1e-37 129.8 0.0 1.3e-37 129.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDW53328.1 - 3.5e-15 56.3 0.0 7.8e-15 55.2 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase TPR_12 PF13424.6 CDW53329.1 - 1.9e-28 98.5 35.6 1.9e-09 37.7 0.4 5.3 2 2 5 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 CDW53329.1 - 4.8e-27 92.6 22.4 2.3e-05 24.0 0.1 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat GoLoco PF02188.17 CDW53329.1 - 6.9e-21 73.4 11.1 1.2e-08 34.2 1.8 3.5 3 0 0 3 3 3 3 GoLoco motif TPR_2 PF07719.17 CDW53329.1 - 6.8e-18 63.3 21.2 0.00045 20.1 0.1 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDW53329.1 - 7.5e-15 53.8 23.4 6.7e-06 25.9 0.1 8.1 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDW53329.1 - 2e-14 52.4 16.7 0.0039 17.1 0.1 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 CDW53329.1 - 9.8e-13 47.5 16.8 0.0029 17.4 0.2 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW53329.1 - 1.3e-05 24.8 3.7 0.057 12.8 0.1 3.2 2 1 0 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 CDW53329.1 - 0.0001 22.8 6.0 4.3 8.4 0.0 5.7 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 CDW53329.1 - 0.0022 18.5 0.3 61 4.7 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 CDW53329.1 - 0.02 14.3 4.5 0.057 12.8 4.5 1.6 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 CDW53329.1 - 0.11 12.2 17.6 0.89 9.3 0.1 6.6 5 3 1 6 6 6 0 TPR repeat TPR_16 PF13432.6 CDW53329.1 - 0.16 12.6 9.1 3.5 8.4 0.2 4.0 4 1 0 4 4 3 0 Tetratricopeptide repeat Sel1 PF08238.12 CDW53329.1 - 2 9.2 4.9 8.2 7.3 0.0 4.0 4 0 0 4 4 4 0 Sel1 repeat TPR_17 PF13431.6 CDW53329.1 - 2.9 8.5 17.3 46 4.7 0.1 7.4 8 1 0 8 8 8 0 Tetratricopeptide repeat Iso_dh PF00180.20 CDW53330.1 - 3.7e-74 250.0 0.0 4.3e-74 249.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 CDW53330.1 - 0.11 13.3 0.1 0.64 10.8 0.0 2.1 2 0 0 2 2 2 0 Phenylalanine zipper TRAM1 PF08390.11 CDW53331.1 - 1.4e-19 69.5 0.2 1.4e-19 69.5 0.2 2.1 2 0 0 2 2 2 1 TRAM1-like protein TRAM_LAG1_CLN8 PF03798.16 CDW53331.1 - 4.1e-17 62.6 18.9 4.1e-17 62.6 18.9 1.6 2 0 0 2 2 2 1 TLC domain BAR_3 PF16746.5 CDW53332.1 - 3.2e-25 89.2 0.5 3.2e-25 89.2 0.5 2.0 2 0 0 2 2 2 1 BAR domain of APPL family PID PF00640.23 CDW53332.1 - 3.2e-10 40.2 0.2 3.2e-10 40.2 0.2 1.8 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PH PF00169.29 CDW53332.1 - 1.8e-08 34.8 0.2 7.5e-08 32.8 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 CDW53332.1 - 0.00016 22.1 0.2 0.00049 20.5 0.2 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain BAR PF03114.18 CDW53332.1 - 0.02 14.6 0.8 0.14 11.7 0.0 2.6 3 0 0 3 3 3 0 BAR domain PID_2 PF14719.6 CDW53332.1 - 0.035 14.0 0.0 0.065 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) FERM_C PF09380.10 CDW53333.1 - 1.5e-19 70.2 0.1 3.1e-19 69.2 0.1 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 CDW53333.1 - 1.7e-15 56.7 0.1 1.8e-14 53.4 0.1 2.4 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.18 CDW53333.1 - 3.6e-12 46.7 0.1 9e-12 45.4 0.1 1.7 1 0 0 1 1 1 1 FERM central domain 4_1_CTD PF05902.13 CDW53333.1 - 0.035 14.2 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) FA PF08736.11 CDW53333.1 - 0.055 13.6 1.0 0.16 12.1 1.0 1.8 1 0 0 1 1 1 0 FERM adjacent (FA) SEEEED PF14797.6 CDW53333.1 - 0.11 12.6 7.9 0.27 11.4 7.9 1.5 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex Aldedh PF00171.22 CDW53334.1 - 3.2e-150 500.7 0.4 2.2e-149 497.9 0.4 1.8 1 1 0 1 1 1 1 Aldehyde dehydrogenase family MOLO1 PF17175.4 CDW53335.1 - 2.5e-27 95.4 0.0 4.5e-27 94.5 0.0 1.4 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 CDW53335.1 - 4.1e-05 23.7 0.0 0.01 16.0 0.0 2.2 2 0 0 2 2 2 2 TPM domain WD40 PF00400.32 CDW53336.1 - 2e-08 34.7 23.2 0.026 15.4 0.1 8.9 10 0 0 10 10 10 2 WD domain, G-beta repeat WD40_like PF17005.5 CDW53336.1 - 2.2e-05 23.9 0.2 0.073 12.4 0.0 4.2 5 0 0 5 5 5 2 WD40-like domain ANAPC4_WD40 PF12894.7 CDW53336.1 - 0.013 15.7 0.2 5.7 7.3 0.0 4.2 5 0 0 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CDW53336.1 - 0.057 13.0 0.0 10 5.6 0.1 3.4 3 0 0 3 3 3 0 PQQ-like domain Rft-1 PF04506.13 CDW53337.1 - 5.1e-91 306.0 33.3 5.5e-72 243.2 15.3 3.0 1 1 1 2 2 2 2 Rft protein DUF373 PF04123.13 CDW53337.1 - 0.69 9.3 14.1 0.81 9.1 3.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF373) TMEM173 PF15009.6 CDW53337.1 - 1.8 7.6 7.9 0.054 12.7 0.8 2.0 2 1 0 2 2 2 0 Transmembrane protein 173 SHMT PF00464.19 CDW53338.1 - 8.1e-183 607.5 0.0 9.4e-183 607.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase HORMA PF02301.18 CDW53339.1 - 5e-38 130.8 0.0 8.6e-38 130.1 0.0 1.4 1 0 0 1 1 1 1 HORMA domain PHD_2 PF13831.6 CDW53339.1 - 0.0043 16.6 4.0 0.005 16.4 0.2 2.8 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 CDW53339.1 - 0.0076 16.1 4.9 0.0076 16.1 4.9 3.2 3 1 1 4 4 4 1 PHD-finger Y_phosphatase PF00102.27 CDW53340.1 - 7.9e-67 225.3 0.2 9.2e-67 225.0 0.2 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 CDW53340.1 - 7.2e-06 25.9 0.0 1.2e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CDW53340.1 - 0.0025 17.8 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CDW53340.1 - 0.0048 17.0 0.0 0.0098 16.0 0.0 1.5 1 1 0 1 1 1 1 Inositol hexakisphosphate Myotub-related PF06602.14 CDW53340.1 - 0.086 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain WAC_Acf1_DNA_bd PF10537.9 CDW53341.1 - 5.5e-13 49.3 0.0 3.3e-12 46.8 0.0 2.4 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 CDW53341.1 - 5.4e-11 42.8 0.3 6.3e-10 39.4 0.0 3.0 2 1 0 2 2 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.29 CDW53341.1 - 2.4e-10 40.1 4.9 8.3e-10 38.4 4.9 2.0 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 CDW53341.1 - 0.008 16.1 3.9 0.025 14.5 3.9 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 FtsH_ext PF06480.15 CDW53341.1 - 0.1 13.0 0.0 0.32 11.4 0.0 1.9 1 0 0 1 1 1 0 FtsH Extracellular zf-HC5HC2H PF13771.6 CDW53341.1 - 0.12 12.7 4.0 0.4 11.0 4.0 2.0 1 0 0 1 1 1 0 PHD-like zinc-binding domain Zf_RING PF16744.5 CDW53341.1 - 0.24 11.5 3.9 0.79 9.9 3.9 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger DDT PF02791.17 CDW53341.1 - 0.4 11.0 4.4 4.1 7.8 2.6 2.9 3 0 0 3 3 3 0 DDT domain C1_2 PF03107.16 CDW53341.1 - 0.41 11.0 4.2 1.5 9.2 4.2 2.0 1 0 0 1 1 1 0 C1 domain PHD_2 PF13831.6 CDW53341.1 - 0.51 9.9 8.9 0.2 11.2 5.7 2.1 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 CDW53341.1 - 3.5 7.6 7.8 0.42 10.5 1.6 2.6 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) BK_channel_a PF03493.18 CDW53342.1 - 1.4e-38 131.0 0.1 8.1e-38 128.6 0.0 2.4 3 0 0 3 3 3 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.31 CDW53342.1 - 2.8e-18 66.1 23.5 5.9e-12 45.3 6.6 2.7 1 1 1 2 2 2 2 Ion transport protein Ion_trans_2 PF07885.16 CDW53342.1 - 1.9e-14 53.4 2.7 1.9e-14 53.4 2.7 2.8 3 0 0 3 3 3 1 Ion channel TrkA_N PF02254.18 CDW53342.1 - 0.00028 21.1 0.0 0.099 12.9 0.0 2.5 2 0 0 2 2 2 1 TrkA-N domain Lig_chan PF00060.26 CDW53342.1 - 0.0087 15.9 2.0 0.023 14.5 0.1 2.4 3 0 0 3 3 3 1 Ligand-gated ion channel 7tm_1 PF00001.21 CDW53342.1 - 0.01 15.2 0.2 0.027 13.8 0.2 1.7 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) PGG PF13962.6 CDW53342.1 - 0.014 15.2 1.6 1.5 8.6 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function Pentapeptide PF00805.22 CDW53342.1 - 0.11 12.2 0.1 1.3 8.7 0.0 2.7 3 0 0 3 3 3 0 Pentapeptide repeats (8 copies) FAM163 PF15069.6 CDW53342.1 - 0.12 12.9 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 FAM163 family SANT_DAMP1_like PF16282.5 CDW53343.1 - 1.9e-25 88.8 0.7 3.6e-25 88.0 0.7 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 CDW53343.1 - 4.8e-20 72.1 1.0 8.2e-20 71.3 1.0 1.4 1 0 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) DUF5383 PF17355.2 CDW53343.1 - 0.48 10.8 4.0 0.46 10.8 2.6 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5383) BK_channel_a PF03493.18 CDW53344.1 - 1e-38 131.4 0.0 3.2e-38 129.9 0.0 1.9 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans PF00520.31 CDW53344.1 - 2.4e-17 63.0 14.9 6.5e-17 61.6 14.9 1.7 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 CDW53344.1 - 9.9e-14 51.1 2.3 9.9e-14 51.1 2.3 2.8 3 0 0 3 3 3 1 Ion channel TrkA_N PF02254.18 CDW53344.1 - 0.04 14.2 0.2 7.2 6.9 0.1 2.6 2 0 0 2 2 2 0 TrkA-N domain SNF PF00209.18 CDW53345.1 - 2.3e-172 574.3 39.2 2.1e-142 475.5 28.9 2.5 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family DUF3263 PF11662.8 CDW53348.1 - 0.22 11.4 0.7 0.38 10.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3263) LRR_8 PF13855.6 CDW53349.1 - 9.2e-49 163.1 56.6 2e-09 37.1 3.7 9.1 3 2 6 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 CDW53349.1 - 2.3e-40 135.9 57.4 9.7e-06 25.8 1.0 10.8 6 4 5 12 12 12 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW53349.1 - 1.5e-07 31.1 27.9 0.068 12.7 0.2 5.4 1 1 5 7 7 7 7 Leucine-rich repeat LRR_1 PF00560.33 CDW53349.1 - 1.7e-07 30.8 52.3 6.6 7.7 0.1 16.4 18 0 0 18 18 18 3 Leucine Rich Repeat LRR_5 PF13306.6 CDW53349.1 - 0.00018 21.5 6.7 0.014 15.4 0.1 4.5 3 3 2 5 5 5 2 BspA type Leucine rich repeat region (6 copies) RsmF_methylt_CI PF17126.5 CDW53349.1 - 0.026 14.5 3.5 23 5.1 0.0 5.8 4 3 3 7 7 7 0 RsmF rRNA methyltransferase first C-terminal domain LRR_6 PF13516.6 CDW53349.1 - 3 8.1 45.6 20 5.6 0.3 13.4 14 0 0 14 14 14 0 Leucine Rich repeat Collagen PF01391.18 CDW53350.1 - 5.8e-24 83.6 102.1 1e-09 38.0 33.0 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW53350.1 - 4.2e-13 49.1 1.0 5.9e-13 48.7 1.0 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain COX14 PF14880.6 CDW53350.1 - 0.013 15.3 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DUF1422 PF07226.11 CDW53350.1 - 0.084 12.9 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1422) His_Phos_2 PF00328.22 CDW53351.1 - 1.6e-17 64.0 0.6 1.8e-15 57.2 0.1 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) SET PF00856.28 CDW53353.1 - 2e-21 77.1 0.1 6.1e-21 75.5 0.1 1.9 1 0 0 1 1 1 1 SET domain Pre-SET PF05033.16 CDW53353.1 - 3.1e-11 43.9 13.9 3.1e-11 43.9 13.9 1.9 2 0 0 2 2 2 1 Pre-SET motif Chromo PF00385.24 CDW53353.1 - 1.1e-05 25.2 0.5 2.2e-05 24.3 0.5 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SH3_1 PF00018.28 CDW53354.1 - 5.1e-69 227.7 12.0 1.7e-16 59.5 0.1 5.8 5 0 0 5 5 5 5 SH3 domain SH3_9 PF14604.6 CDW53354.1 - 3e-61 203.1 4.4 8e-14 51.2 0.1 5.7 5 0 0 5 5 5 5 Variant SH3 domain SH3_2 PF07653.17 CDW53354.1 - 8.8e-48 159.8 2.6 1.5e-10 40.6 0.0 5.4 5 0 0 5 5 5 5 Variant SH3 domain RhoGEF PF00621.20 CDW53354.1 - 1.8e-33 116.3 0.6 4.6e-32 111.7 0.0 2.5 2 0 0 2 2 2 1 RhoGEF domain PH_13 PF16652.5 CDW53354.1 - 1.7e-31 109.2 0.0 1.7e-31 109.2 0.0 2.0 2 0 0 2 2 1 1 Pleckstrin homology domain EF-hand_4 PF12763.7 CDW53354.1 - 5.8e-25 87.3 0.0 2.1e-11 43.7 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Glyco_tran_28_C PF04101.16 CDW53354.1 - 2.4e-22 79.7 0.1 1.2e-21 77.5 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain EF-hand_1 PF00036.32 CDW53354.1 - 8.7e-07 28.1 0.1 0.035 13.7 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CDW53354.1 - 0.00011 21.8 0.2 0.39 10.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 CDW53354.1 - 0.0011 19.4 0.0 0.58 10.6 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 CDW53354.1 - 0.0025 17.6 0.5 0.029 14.2 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair PCB_OB PF17092.5 CDW53354.1 - 0.025 15.3 0.0 9.8 7.0 0.0 4.3 5 0 0 5 5 4 0 Penicillin-binding protein OB-like domain EF-hand_5 PF13202.6 CDW53354.1 - 0.08 12.5 0.0 17 5.1 0.0 2.9 2 0 0 2 2 2 0 EF hand DNase_II PF03265.15 CDW53355.1 - 3.5e-49 167.8 0.0 4.3e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II SWIM PF04434.17 CDW53356.1 - 0.12 12.0 7.2 0.35 10.6 7.2 1.9 1 0 0 1 1 1 0 SWIM zinc finger DmpG_comm PF07836.11 CDW53356.1 - 0.16 11.5 0.0 22 4.7 0.0 2.8 3 0 0 3 3 3 0 DmpG-like communication domain FemAB_like PF04339.12 CDW53356.1 - 1 8.4 3.3 1 8.4 0.5 2.0 2 0 0 2 2 2 0 Peptidogalycan biosysnthesis/recognition TFIIA_gamma_N PF02268.16 CDW53357.1 - 6e-21 74.2 0.8 8e-21 73.8 0.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 CDW53357.1 - 2e-18 66.3 1.0 3.2e-18 65.6 1.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit Aldedh PF00171.22 CDW53358.1 - 9e-176 584.9 0.0 1.1e-174 581.3 0.0 1.9 1 1 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CDW53358.1 - 0.091 12.2 0.3 0.97 8.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) BolA PF01722.18 CDW53359.1 - 4.9e-09 36.3 0.1 6.6e-09 35.9 0.1 1.2 1 0 0 1 1 1 1 BolA-like protein SH3_9 PF14604.6 CDW53360.1 - 1.2e-05 25.1 0.0 2.1e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW53360.1 - 2.8e-05 23.6 0.0 4.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 SH3 domain E1_dh PF00676.20 CDW53361.1 - 1.8e-73 247.1 0.0 3.2e-73 246.3 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 CDW53361.1 - 8.2e-66 221.1 0.0 4.3e-65 218.7 0.0 2.0 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 CDW53361.1 - 6.1e-50 168.9 0.0 1e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CDW53361.1 - 7.3e-21 73.5 6.5 3e-20 71.5 0.2 3.4 3 0 0 3 3 3 1 2-oxoglutarate dehydrogenase N-terminus Elongin_A PF06881.11 CDW53361.1 - 0.0073 16.8 1.0 8.5 7.0 0.0 2.8 2 0 0 2 2 2 2 RNA polymerase II transcription factor SIII (Elongin) subunit A R2K_2 PF18299.1 CDW53361.1 - 0.061 13.2 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 CTP_transf_1 PF01148.20 CDW53362.1 - 3.9e-77 259.6 23.1 4.7e-77 259.3 23.1 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family LRR19-TM PF15176.6 CDW53362.1 - 0.052 13.6 0.3 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain SF3A2 PF16835.5 CDW53363.1 - 9.7e-40 134.9 0.1 1.6e-39 134.2 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 CDW53363.1 - 4.6e-07 30.0 2.0 4.6e-07 30.0 2.0 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 CDW53363.1 - 8e-05 22.6 0.2 0.00014 21.8 0.2 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein DUF1143 PF06608.11 CDW53363.1 - 0.075 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) zf-C2H2_jaz PF12171.8 CDW53363.1 - 6.6 7.1 6.1 11 6.5 4.5 2.2 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Syja_N PF02383.18 CDW53364.1 - 2.5e-50 171.6 0.0 6.2e-49 167.0 0.0 2.3 1 1 1 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.23 CDW53364.1 - 5.6e-14 52.2 0.4 8.4e-14 51.6 0.4 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1866 PF08952.11 CDW53364.1 - 0.0012 18.7 0.0 0.0047 16.8 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1866) Clc-like PF07062.12 CDW53365.1 - 8.3e-26 90.8 18.4 2.2e-24 86.2 18.4 2.0 1 1 0 1 1 1 1 Clc-like DUF4781 PF16013.5 CDW53365.1 - 0.00022 20.1 0.7 0.00022 20.1 0.7 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4781) SLATT_4 PF18186.1 CDW53365.1 - 0.09 12.4 0.8 1.8 8.2 0.0 2.6 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 4 Claudin_3 PF06653.11 CDW53365.1 - 0.95 9.4 18.0 0.72 9.8 11.6 2.9 2 1 1 3 3 3 0 Tight junction protein, Claudin-like DUF2062 PF09835.9 CDW53365.1 - 2.6 7.9 11.1 0.45 10.4 1.2 2.6 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2062) Ion_trans PF00520.31 CDW53368.1 - 1.4e-240 794.1 82.7 1.5e-62 211.0 19.1 4.1 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 CDW53368.1 - 2.6e-25 87.9 0.0 7.3e-25 86.5 0.0 1.8 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.11 CDW53368.1 - 1.6e-21 76.2 0.0 4e-21 75.0 0.0 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.12 CDW53368.1 - 9.5e-05 21.2 19.4 9.5e-05 21.2 19.4 8.4 6 3 1 7 7 7 5 Polycystin cation channel EF-hand_11 PF08976.11 CDW53368.1 - 0.11 13.4 0.0 0.28 12.1 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain S1FA PF04689.13 CDW53368.1 - 0.78 9.9 5.0 26 5.1 0.1 4.1 2 0 0 2 2 2 0 DNA binding protein S1FA MOR2-PAG1_C PF14225.6 CDW53369.1 - 1.1e-53 182.8 4.0 2.2e-53 181.7 0.5 2.5 2 0 0 2 2 2 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 CDW53369.1 - 3.7e-24 84.5 14.1 7.6e-08 30.5 0.3 5.1 5 0 0 5 5 5 5 Cell morphogenesis central region Pribosyltran_N PF13793.6 CDW53370.1 - 1.6e-46 157.0 2.0 7.6e-46 154.8 0.1 2.4 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CDW53370.1 - 3.3e-44 151.1 1.7 3.8e-37 128.1 0.7 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CDW53370.1 - 3e-14 52.8 0.6 5.6e-14 52.0 0.2 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDW53370.1 - 2e-05 24.1 0.1 3.5e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Chlorosome_CsmC PF11098.8 CDW53370.1 - 0.053 13.5 0.2 0.091 12.8 0.2 1.4 1 0 0 1 1 1 0 Chlorosome envelope protein C DUF3247 PF11607.8 CDW53370.1 - 0.06 13.6 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) zf-C2H2_12 PF18658.1 CDW53371.1 - 0.001 18.6 3.2 1 9.0 0.0 3.2 2 1 1 3 3 3 2 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 CDW53371.1 - 0.0022 18.7 14.2 0.09 13.7 1.2 3.9 3 1 0 3 3 3 2 C2H2-type zinc finger zf-BED PF02892.15 CDW53371.1 - 0.29 11.2 8.9 1.2 9.2 0.3 3.4 3 0 0 3 3 3 0 BED zinc finger DUF678 PF05077.12 CDW53371.1 - 0.51 10.5 5.2 24 5.1 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF678) zf-C2HE PF16278.5 CDW53371.1 - 0.92 10.0 5.5 0.17 12.3 0.4 2.6 3 1 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Thioredoxin_6 PF13848.6 CDW53372.1 - 0.04 13.8 0.0 0.064 13.2 0.0 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain PAS_3 PF08447.12 CDW53373.1 - 5.4e-10 39.4 0.0 9.6e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 PAS fold HLH PF00010.26 CDW53373.1 - 8e-08 32.1 1.2 1.5e-07 31.3 1.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_11 PF14598.6 CDW53373.1 - 4.6e-07 29.9 0.0 1.2e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 CDW53373.1 - 0.0035 17.3 0.0 0.72 9.9 0.0 2.4 2 0 0 2 2 2 2 PAS fold zf-Tim10_DDP PF02953.15 CDW53374.1 - 7.7e-19 67.1 0.2 9.4e-19 66.8 0.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Arfaptin PF06456.13 CDW53375.1 - 1.1e-47 162.6 10.6 1.3e-47 162.3 10.6 1.1 1 0 0 1 1 1 1 Arfaptin-like domain BAR PF03114.18 CDW53375.1 - 1.8e-07 31.1 7.3 9.4e-07 28.7 7.3 2.3 1 1 0 1 1 1 1 BAR domain TPR_MLP1_2 PF07926.12 CDW53375.1 - 0.0064 16.6 13.0 0.016 15.3 2.8 2.8 2 1 0 2 2 2 2 TPR/MLP1/MLP2-like protein CC2-LZ PF16516.5 CDW53375.1 - 0.013 15.9 0.3 0.013 15.9 0.3 2.4 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator APG6_N PF17675.1 CDW53375.1 - 0.015 15.8 10.1 0.84 10.2 2.5 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF745 PF05335.13 CDW53375.1 - 0.12 12.0 10.3 0.089 12.5 2.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF745) TMF_TATA_bd PF12325.8 CDW53375.1 - 1.9 8.8 8.6 0.79 10.0 0.6 3.0 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DMPK_coil PF08826.10 CDW53375.1 - 3.8 7.7 11.0 11 6.2 1.3 4.2 3 1 1 4 4 4 0 DMPK coiled coil domain like DUF1043 PF06295.12 CDW53375.1 - 5.1 7.1 11.8 0.56 10.2 3.5 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1043) NARP1 PF12569.8 CDW53376.1 - 2.6e-180 600.7 13.4 2.6e-180 600.7 13.4 2.1 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 CDW53376.1 - 1.9e-18 65.0 24.5 0.00078 19.4 0.4 9.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 CDW53376.1 - 3.1e-13 49.1 10.7 2.6e-05 23.8 0.1 6.5 6 1 0 6 6 6 3 TPR repeat TPR_14 PF13428.6 CDW53376.1 - 3.7e-13 49.1 7.0 0.16 12.8 0.0 8.9 6 2 3 9 9 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDW53376.1 - 1e-11 44.1 25.9 0.00039 20.1 0.5 8.5 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW53376.1 - 1.9e-09 37.9 9.7 0.036 14.6 0.4 5.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDW53376.1 - 5.2e-09 35.6 26.5 0.0048 17.0 0.3 8.5 9 0 0 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW53376.1 - 5.6e-08 32.9 17.8 0.016 15.4 0.3 5.8 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 CDW53376.1 - 2.8e-07 31.1 9.8 0.85 10.3 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDW53376.1 - 3.1e-07 30.6 23.5 0.047 14.0 2.2 7.8 6 2 1 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDW53376.1 - 9.7e-05 22.1 16.9 9.8 6.5 0.1 7.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_4 PF07721.14 CDW53376.1 - 0.0011 19.4 3.7 0.28 11.9 0.8 3.6 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDW53376.1 - 0.0074 15.5 15.6 0.13 11.5 0.1 4.1 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW53376.1 - 0.051 13.0 8.1 0.39 10.0 0.0 3.3 3 1 0 3 3 3 0 MalT-like TPR region Fis1_TPR_C PF14853.6 CDW53376.1 - 0.11 12.5 13.5 1.1 9.4 2.9 4.3 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 CDW53376.1 - 0.14 12.2 4.7 2.2 8.4 0.4 3.7 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 CDW53376.1 - 0.15 11.9 18.2 3.2 7.8 0.3 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDW53376.1 - 0.22 12.0 0.0 0.22 12.0 0.0 6.0 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDW53376.1 - 0.68 10.1 11.1 5.2 7.3 0.1 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Pyr_redox_2 PF07992.14 CDW53378.1 - 4.3e-30 105.0 0.0 2.4e-17 63.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDW53378.1 - 1.8e-29 102.2 0.2 7.5e-28 97.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 CDW53378.1 - 0.00061 19.1 3.1 0.5 9.6 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDW53378.1 - 0.016 14.3 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CDW53378.1 - 0.17 10.9 0.5 0.58 9.2 0.6 1.7 2 0 0 2 2 2 0 FAD binding domain Phospholip_A2_2 PF05826.12 CDW53379.1 - 9e-24 83.5 5.9 1.6e-23 82.7 3.1 2.2 2 0 0 2 2 2 1 Phospholipase A2 Phospholip_A2_1 PF00068.19 CDW53379.1 - 0.027 14.9 9.8 0.19 12.2 7.6 2.7 1 1 0 1 1 1 0 Phospholipase A2 GalP_UDP_transf PF01087.22 CDW53380.1 - 1e-50 172.7 0.0 1.6e-50 172.1 0.0 1.2 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 CDW53380.1 - 2.9e-49 167.0 0.0 4.5e-49 166.4 0.0 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain Glucosamine_iso PF01182.20 CDW53381.1 - 2.5e-18 66.8 0.0 3.6e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Bys1 PF04681.12 CDW53381.1 - 0.042 13.8 0.5 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 Blastomyces yeast-phase-specific protein 7TM_GPCR_Srsx PF10320.9 CDW53383.1 - 0.00019 20.9 12.0 0.00024 20.6 12.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx UPF0093 PF03653.13 CDW53383.1 - 0.027 14.7 5.1 0.026 14.7 2.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0093) Glyco_hydro_20 PF00728.22 CDW53384.1 - 1.9e-84 284.1 0.0 2.8e-84 283.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 CDW53384.1 - 1.1e-13 52.0 0.0 2.2e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Viral_cys_rich PF08008.12 CDW53384.1 - 0.0034 17.4 0.2 0.16 12.1 0.1 2.6 2 0 0 2 2 2 1 Viral cysteine rich VEFS-Box PF09733.9 CDW53385.1 - 9.1e-09 35.2 0.1 1.2e-08 34.9 0.1 1.2 1 0 0 1 1 1 1 VEFS-Box of polycomb protein Claudin_2 PF13903.6 CDW53386.1 - 0.0072 16.1 12.1 0.03 14.1 10.6 2.0 1 1 1 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction DUF2569 PF10754.9 CDW53386.1 - 0.68 10.4 11.3 0.44 11.0 3.0 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF2569) Polysacc_synt_C PF14667.6 CDW53386.1 - 0.81 9.7 13.6 1.8 8.6 10.0 2.6 2 1 1 3 3 3 0 Polysaccharide biosynthesis C-terminal domain MerC PF03203.14 CDW53386.1 - 0.83 10.1 10.8 1.1 9.7 6.8 2.4 2 1 0 2 2 2 0 MerC mercury resistance protein Saf_2TM PF18303.1 CDW53386.1 - 1 8.9 3.2 2.8 7.5 0.0 2.4 2 1 0 2 2 2 0 SAVED-fused 2TM effector domain DUF202 PF02656.15 CDW53386.1 - 3.7 8.1 10.8 12 6.4 1.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF202) Wzy_C PF04932.15 CDW53386.1 - 3.7 7.2 6.2 7.7 6.1 2.5 2.6 2 1 0 2 2 2 0 O-Antigen ligase Gpr1_Fun34_YaaH PF01184.19 CDW53387.1 - 0.11 12.1 0.7 0.15 11.6 0.7 1.2 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family Syntaxin PF00804.25 CDW53388.1 - 5.1e-30 104.6 7.0 6.8e-30 104.2 7.0 1.1 1 0 0 1 1 1 1 Syntaxin Syntaxin_2 PF14523.6 CDW53388.1 - 3.6e-11 43.3 4.2 6e-11 42.6 4.2 1.3 1 0 0 1 1 1 1 Syntaxin-like protein FapA PF03961.13 CDW53388.1 - 0.0024 16.6 6.0 0.0027 16.4 6.0 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF848 PF05852.11 CDW53388.1 - 0.0088 16.2 3.4 0.012 15.7 3.4 1.4 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) AAA_13 PF13166.6 CDW53388.1 - 0.0092 14.7 4.9 0.011 14.4 4.9 1.0 1 0 0 1 1 1 1 AAA domain WXG100 PF06013.12 CDW53388.1 - 0.011 15.9 1.1 1.5 9.1 0.3 3.0 3 0 0 3 3 3 0 Proteins of 100 residues with WXG SIMPL PF04402.14 CDW53388.1 - 0.014 15.8 0.6 0.028 14.9 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF541) adh_short_C2 PF13561.6 CDW53388.1 - 0.021 14.4 0.5 0.031 13.8 0.4 1.4 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Ferritin PF00210.24 CDW53388.1 - 0.028 14.4 0.5 0.047 13.6 0.5 1.4 1 0 0 1 1 1 0 Ferritin-like domain Complex1_49kDa PF00346.19 CDW53388.1 - 0.052 12.6 1.4 0.081 12.0 0.6 1.5 1 1 1 2 2 2 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit DUF4600 PF15372.6 CDW53388.1 - 0.064 13.7 6.2 0.092 13.2 6.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) Branch PF02485.21 CDW53388.1 - 0.066 12.7 0.2 0.08 12.4 0.2 1.2 1 0 0 1 1 1 0 Core-2/I-Branching enzyme DUF2205 PF10224.9 CDW53388.1 - 0.089 12.8 0.1 0.089 12.8 0.1 2.4 2 1 1 3 3 2 0 Short coiled-coil protein DUF948 PF06103.11 CDW53388.1 - 0.1 12.8 2.7 0.63 10.3 0.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Phage_GPO PF05929.11 CDW53388.1 - 0.11 12.1 4.3 0.09 12.4 3.1 1.4 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase adh_short PF00106.25 CDW53388.1 - 0.12 11.8 1.0 0.27 10.6 0.1 1.8 1 1 0 2 2 2 0 short chain dehydrogenase Nup54 PF13874.6 CDW53388.1 - 0.14 12.2 5.2 3.7 7.6 3.1 2.4 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF4456 PF14644.6 CDW53388.1 - 0.17 11.5 4.9 0.15 11.7 1.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) P4Ha_N PF08336.11 CDW53388.1 - 0.25 11.3 4.8 0.57 10.2 0.1 2.3 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Prominin PF05478.11 CDW53388.1 - 0.37 8.7 4.1 0.45 8.4 4.1 1.1 1 0 0 1 1 1 0 Prominin DUF148 PF02520.17 CDW53388.1 - 0.41 10.8 7.4 0.68 10.1 5.2 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF148 TMPIT PF07851.13 CDW53388.1 - 0.68 9.1 3.6 0.84 8.8 3.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein YtxH PF12732.7 CDW53388.1 - 0.79 10.3 4.8 1 9.9 2.4 2.4 2 1 0 2 2 1 0 YtxH-like protein RecG_N PF17190.4 CDW53388.1 - 0.83 10.4 7.9 1 10.1 3.2 2.4 1 1 1 2 2 2 0 RecG N-terminal helical domain Fib_alpha PF08702.10 CDW53388.1 - 0.89 9.7 7.2 2.4 8.3 7.2 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family GP24_25 PF17388.2 CDW53388.1 - 1.1 9.3 6.9 0.17 11.9 1.8 1.9 1 1 1 2 2 2 0 Tail assembly gene products 24 & 25 DUF1947 PF09183.10 CDW53388.1 - 1.2 9.5 5.7 0.27 11.5 0.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF1947) Uso1_p115_C PF04871.13 CDW53388.1 - 2.3 8.6 9.8 11 6.3 6.1 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF3347 PF11827.8 CDW53388.1 - 2.3 8.4 6.8 9.1 6.4 6.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3347) FlaC_arch PF05377.11 CDW53388.1 - 5.5 7.5 7.8 30 5.1 0.2 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Mito_carr PF00153.27 CDW53389.1 - 8.8e-16 57.6 0.0 1e-15 57.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein p450 PF00067.22 CDW53390.1 - 5.6e-63 213.3 0.2 6.1e-63 213.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sel1 PF08238.12 CDW53391.1 - 1.2e-49 165.6 32.7 1.4e-05 25.6 0.3 13.1 13 0 0 13 13 13 10 Sel1 repeat Ribosomal_S5_C PF03719.15 CDW53391.1 - 1.1e-19 69.6 0.0 2.2e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CDW53391.1 - 1.7e-14 53.5 0.5 4.9e-14 52.1 0.5 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Flu_M1_C PF08289.11 CDW53391.1 - 0.0059 16.8 0.0 0.081 13.1 0.0 2.6 2 0 0 2 2 2 1 Influenza Matrix protein (M1) C-terminal domain TPR_11 PF13414.6 CDW53391.1 - 0.054 13.2 0.2 0.054 13.2 0.2 3.0 3 0 0 3 3 3 0 TPR repeat Rhabdo_M2 PF04785.12 CDW53392.1 - 0.03 13.6 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus matrix protein M2 HAD_2 PF13419.6 CDW53392.1 - 0.093 12.8 0.2 0.16 12.1 0.2 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Mrx7 PF10906.8 CDW53393.1 - 0.21 11.8 0.9 0.96 9.7 0.1 2.3 2 0 0 2 2 2 0 MIOREX complex component 7 Glyco_transf_10 PF00852.19 CDW53394.1 - 9.8e-58 194.8 5.0 1.4e-57 194.3 5.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW53394.1 - 2.2e-24 86.1 1.2 4.5e-24 85.0 0.2 2.1 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal IL11 PF07400.11 CDW53394.1 - 0.11 12.2 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Interleukin 11 DUF4975 PF16346.5 CDW53394.1 - 0.12 12.5 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) Diphthami_syn_2 PF01902.17 CDW53395.1 - 3.1e-35 121.7 0.0 1.4e-30 106.5 0.0 2.4 2 1 0 2 2 2 2 Diphthamide synthase DUF1041 PF06292.17 CDW53396.1 - 5.3e-21 75.0 1.5 1.3e-20 73.7 1.5 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1041) PH PF00169.29 CDW53396.1 - 3.1e-06 27.6 2.3 8.2e-06 26.3 0.0 2.6 3 0 0 3 3 3 1 PH domain GNAT_acetyltr_2 PF13718.6 CDW53396.1 - 0.11 11.9 0.1 0.27 10.6 0.1 1.6 1 0 0 1 1 1 0 GNAT acetyltransferase 2 PNP_UDP_1 PF01048.20 CDW53397.1 - 9.3e-44 149.4 0.3 1e-43 149.3 0.3 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily RabGAP-TBC PF00566.18 CDW53398.1 - 1.1e-37 129.8 2.1 1.1e-37 129.8 2.1 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF4682 PF15733.5 CDW53398.1 - 2.4e-05 24.9 0.1 2.4e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4682) ClpB_D2-small PF10431.9 CDW53398.1 - 0.0081 16.2 1.3 0.011 15.7 0.1 1.9 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein Ldl_recept_a PF00057.18 CDW53398.1 - 0.028 14.6 1.0 0.13 12.5 1.0 2.1 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A FEZ PF07763.13 CDW53398.1 - 0.035 13.8 1.1 7.9 6.1 0.1 2.8 2 0 0 2 2 2 0 FEZ-like protein DUF1192 PF06698.11 CDW53398.1 - 0.069 13.2 0.1 0.25 11.4 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Globin PF00042.22 CDW53399.1 - 1.4e-11 44.9 0.2 2.6e-11 44.1 0.0 1.5 2 0 0 2 2 2 1 Globin HU-CCDC81_euk_1 PF14908.6 CDW53399.1 - 0.064 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 Pkinase_Tyr PF07714.17 CDW53400.1 - 2.5e-81 272.8 0.0 3.3e-81 272.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW53400.1 - 3.5e-41 141.3 0.0 4.9e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PBD PF00786.28 CDW53400.1 - 0.00064 20.0 0.0 0.0019 18.5 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain SH3_2 PF07653.17 CDW53400.1 - 0.0038 16.9 0.0 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.14 CDW53400.1 - 0.027 13.8 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDW53400.1 - 0.11 11.4 0.0 0.11 11.4 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain RLL PF10036.9 CDW53401.1 - 8.9e-74 248.6 0.1 1e-73 248.4 0.1 1.0 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein S-AdoMet_synt_C PF02773.16 CDW53402.1 - 5.7e-64 214.2 0.0 1.2e-63 213.2 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 CDW53402.1 - 6.7e-38 129.4 0.3 1.3e-37 128.5 0.3 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 CDW53402.1 - 9.6e-38 129.1 0.0 2.8e-37 127.6 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain Methyltransf_11 PF08241.12 CDW53404.1 - 3.2e-12 46.9 0.0 5.5e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW53404.1 - 7.8e-10 39.3 0.0 1.2e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 CDW53404.1 - 8.5e-09 35.3 0.0 9.5e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_31 PF13847.6 CDW53404.1 - 1.3e-08 34.8 0.0 1.7e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW53404.1 - 4.3e-05 23.4 0.0 4.9e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW53404.1 - 0.00017 22.2 0.0 0.00023 21.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 CDW53404.1 - 0.01 14.4 0.0 0.033 12.7 0.0 1.7 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase RT_RNaseH PF17917.1 CDW53404.1 - 0.036 14.4 0.1 0.67 10.3 0.0 2.3 2 1 1 3 3 3 0 RNase H-like domain found in reverse transcriptase EstA_Ig_like PF18435.1 CDW53404.1 - 0.046 13.9 0.0 0.077 13.2 0.0 1.3 1 0 0 1 1 1 0 Esterase Ig-like N-terminal domain Spermine_synth PF01564.17 CDW53405.1 - 1.7e-08 34.1 0.1 2.9e-08 33.4 0.1 1.3 1 1 0 1 1 1 1 Spermine/spermidine synthase domain PCMT PF01135.19 CDW53405.1 - 0.00077 19.3 0.0 0.0012 18.6 0.0 1.3 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_3 PF01596.17 CDW53405.1 - 0.0014 17.9 0.0 0.002 17.4 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.6 CDW53405.1 - 0.0028 18.3 0.0 0.0048 17.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW53405.1 - 0.0057 16.2 0.0 0.0085 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_5 PF01795.19 CDW53405.1 - 0.012 15.1 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family Methyltransf_12 PF08242.12 CDW53405.1 - 0.012 16.3 0.0 0.022 15.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 CDW53405.1 - 0.025 14.1 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_2 PF00891.18 CDW53405.1 - 0.058 12.7 0.0 0.076 12.3 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_10 PF05971.12 CDW53405.1 - 0.093 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA methyltransferase Phage_TAC_10 PF10963.8 CDW53405.1 - 0.12 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone UDPGP PF01704.18 CDW53406.1 - 1.8e-54 185.0 0.0 2.3e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 CDW53406.1 - 0.011 16.1 0.0 0.028 14.8 0.0 1.7 1 0 0 1 1 1 0 MobA-like NTP transferase domain PIG-P PF08510.12 CDW53407.1 - 5.2e-20 71.6 9.1 6.1e-20 71.3 9.1 1.1 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 CDW53407.1 - 0.052 13.9 6.8 0.1 12.9 6.8 1.5 1 1 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DPM3 PF08285.11 CDW53407.1 - 0.92 9.7 4.7 1.3 9.3 4.7 1.2 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DnaJ_CXXCXGXG PF00684.19 CDW53408.1 - 0.0074 16.6 26.0 2.5 8.5 6.6 4.2 2 2 0 2 2 2 2 DnaJ central domain ELO PF01151.18 CDW53409.1 - 1.4e-67 227.9 25.9 1.7e-67 227.6 25.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PrgI PF12666.7 CDW53409.1 - 2.3 9.0 6.0 2.6 8.8 0.6 2.9 3 1 0 3 3 3 0 PrgI family protein CAML PF14963.6 CDW53410.1 - 0.0003 21.0 4.8 0.015 15.4 0.0 2.2 2 0 0 2 2 2 2 Calcium signal-modulating cyclophilin ligand DUF2370 PF10176.9 CDW53410.1 - 1.3 8.6 2.8 3.7 7.1 1.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2370) Kunitz_BPTI PF00014.23 CDW53412.1 - 1.3e-191 620.9 74.8 1.2e-17 63.9 1.5 12.4 12 0 0 12 12 12 12 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 CDW53412.1 - 3.3e-64 213.0 121.2 5.7e-12 45.8 5.3 10.4 9 0 0 9 9 9 9 Lustrin, cysteine-rich repeated domain Peptidase_M13 PF01431.21 CDW53413.1 - 8.6e-66 221.4 0.0 1e-65 221.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 Tox-MPTase2 PF15638.6 CDW53413.1 - 0.01 15.6 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase toxin 2 Thyroglobulin_1 PF00086.18 CDW53414.1 - 5.3e-05 22.8 1.2 0.00012 21.7 1.2 1.7 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Thyroglobulin_1 PF00086.18 CDW53415.1 - 9.9e-23 79.6 9.8 7e-12 44.8 2.2 2.8 2 1 0 2 2 2 2 Thyroglobulin type-1 repeat Laminin_EGF PF00053.24 CDW53415.1 - 0.86 9.8 6.6 1.6 9.0 1.0 3.0 2 0 0 2 2 2 0 Laminin EGF domain Cys_rich_CWC PF14375.6 CDW53415.1 - 2.5 8.6 8.7 9.9 6.7 1.4 3.1 2 1 0 2 2 2 0 Cysteine-rich CWC Plus-3 PF03126.18 CDW53416.1 - 1.9e-27 95.9 0.9 1.7e-26 92.9 0.1 2.7 2 1 1 3 3 3 1 Plus-3 domain GH-E PF14410.6 CDW53416.1 - 0.69 10.3 4.7 4.3 7.8 0.1 3.6 4 0 0 4 4 4 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues zf-RING_2 PF13639.6 CDW53417.1 - 9.7e-06 25.8 7.6 9.7e-06 25.8 7.6 2.5 1 1 1 2 2 2 1 Ring finger domain Zn_ribbon_17 PF17120.5 CDW53417.1 - 0.00011 21.8 5.6 0.00011 21.8 5.6 2.9 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 CDW53417.1 - 0.00042 20.5 6.5 0.00042 20.5 6.5 2.8 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDW53417.1 - 0.001 19.1 7.7 0.0029 17.6 7.4 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CDW53417.1 - 0.0014 18.6 4.9 0.0014 18.6 4.9 2.5 2 2 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDW53417.1 - 0.0018 18.1 3.1 0.0018 18.1 3.1 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW53417.1 - 0.0024 17.7 5.2 0.0024 17.7 5.2 2.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDW53417.1 - 0.024 14.8 5.2 0.024 14.8 5.2 2.7 1 1 1 2 2 1 0 FANCL C-terminal domain Zf_RING PF16744.5 CDW53417.1 - 0.033 14.3 3.8 0.033 14.3 3.8 2.8 2 1 0 2 2 2 0 KIAA1045 RING finger RINGv PF12906.7 CDW53417.1 - 0.041 14.0 2.3 0.041 14.0 2.3 3.3 2 1 0 2 2 1 0 RING-variant domain zf-B_box PF00643.24 CDW53417.1 - 0.29 11.3 13.7 0.46 10.7 6.7 3.1 3 0 0 3 3 3 0 B-box zinc finger Prok-RING_4 PF14447.6 CDW53417.1 - 1.7 8.6 0.1 1 9.3 0.7 3.1 3 0 0 3 3 2 0 Prokaryotic RING finger family 4 Kunitz_BPTI PF00014.23 CDW53418.1 - 6.1e-185 599.5 174.7 4.9e-18 65.1 8.4 12.5 12 0 0 12 12 12 12 Kunitz/Bovine pancreatic trypsin inhibitor domain Thyroglobulin_1 PF00086.18 CDW53418.1 - 2.9e-15 55.7 2.3 7.7e-15 54.3 2.3 1.8 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat Lustrin_cystein PF14625.6 CDW53418.1 - 2.3e-07 31.1 18.7 1.8e-05 25.0 6.5 6.0 5 0 0 5 5 5 2 Lustrin, cysteine-rich repeated domain B56 PF01603.20 CDW53420.1 - 9.7e-155 515.6 10.4 1.3e-126 423.0 1.3 2.0 1 1 1 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 CDW53420.1 - 0.012 15.5 0.4 0.15 12.0 0.1 2.5 1 1 1 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal SMK-1 PF04802.15 CDW53421.1 - 1.7e-62 210.6 4.5 2.5e-62 210.1 2.9 2.0 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 Aldedh PF00171.22 CDW53422.1 - 1.2e-172 574.6 0.0 1.6e-172 574.2 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Cadherin PF00028.17 CDW53423.1 - 7.2e-109 356.5 0.0 2.6e-12 47.0 0.1 17.9 17 3 0 17 17 17 14 Cadherin domain Cadherin_3 PF16184.5 CDW53423.1 - 1.7e-09 37.6 5.2 1.8 8.6 0.1 9.2 10 0 0 10 10 10 3 Cadherin-like Cadherin_2 PF08266.12 CDW53423.1 - 0.00027 20.7 0.0 8.6 6.3 0.0 5.9 7 0 0 7 7 7 2 Cadherin-like LSM PF01423.22 CDW53424.1 - 3.9e-09 36.1 0.0 4.4e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain ETX_MTX2 PF03318.13 CDW53425.1 - 3.2e-05 23.8 0.2 5.7e-05 23.0 0.2 1.3 1 1 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Phage_pRha PF09669.10 CDW53425.1 - 0.0067 17.0 0.0 0.015 15.9 0.0 1.6 1 0 0 1 1 1 1 Phage regulatory protein Rha (Phage_pRha) Proteasome PF00227.26 CDW53426.1 - 4.2e-42 143.8 1.5 4.7e-42 143.6 1.5 1.0 1 0 0 1 1 1 1 Proteasome subunit YopE PF03545.13 CDW53426.1 - 0.1 12.8 0.7 0.1 12.8 0.7 2.0 3 0 0 3 3 3 0 Yersinia virulence determinant (YopE) TCR PF03638.15 CDW53427.1 - 1.8e-23 82.5 55.0 1.6e-11 44.3 21.1 2.5 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 CDW53427.1 - 0.00095 19.3 46.2 0.017 15.3 20.6 2.7 2 0 0 2 2 2 2 CXC domain of E3 ubiquitin-protein ligase MSL2 Beta-Casp PF10996.8 CDW53428.1 - 1.8e-30 105.5 0.0 3.3e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 CDW53428.1 - 7.4e-19 67.4 0.0 1.5e-18 66.4 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 CDW53428.1 - 1.9e-17 63.3 0.0 3.4e-17 62.5 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 CDW53428.1 - 1.7e-16 60.8 0.0 2.5e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDW53428.1 - 4e-08 33.0 0.1 1.6e-07 31.0 0.0 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain CPSF73-100_C PF11718.8 CDW53428.1 - 5e-06 26.2 0.1 8.2e-06 25.5 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_3 PF13483.6 CDW53428.1 - 9.3e-06 25.6 0.0 5.7e-05 23.1 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 CDW53428.1 - 0.0028 16.9 0.0 0.0071 15.6 0.0 1.6 2 0 0 2 2 2 1 Putative beta-lactamase-like family DUF3213 PF11491.8 CDW53428.1 - 0.14 12.4 0.1 0.47 10.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3213) Ribosomal_L1 PF00687.21 CDW53429.1 - 1.3e-08 34.8 0.0 1.9e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DEAD PF00270.29 CDW53430.1 - 1.1e-49 168.6 0.1 3.1e-49 167.1 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW53430.1 - 7.5e-28 97.1 0.0 3.1e-26 91.9 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Terminase_6 PF03237.15 CDW53430.1 - 0.029 14.0 0.4 6.7 6.3 0.0 2.8 2 0 0 2 2 2 0 Terminase-like family GIDE PF12483.8 CDW53430.1 - 0.035 13.5 1.0 0.078 12.4 1.0 1.6 1 0 0 1 1 1 0 E3 Ubiquitin ligase Caprin-1_dimer PF18293.1 CDW53430.1 - 0.067 13.7 2.2 0.15 12.6 0.2 2.6 2 0 0 2 2 2 0 Caprin-1 dimerization domain DUF3947 PF13135.6 CDW53430.1 - 0.21 11.8 0.5 0.64 10.2 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) PRA1 PF03208.19 CDW53431.1 - 7.8e-23 80.7 9.7 8.1e-19 67.7 6.8 2.0 2 0 0 2 2 2 2 PRA1 family protein Anoctamin PF04547.12 CDW53432.1 - 2.5e-60 204.6 8.6 3.7e-60 204.0 8.6 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 CDW53432.1 - 3.4e-44 151.2 0.0 4.9e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin DAGK_prokar PF01219.19 CDW53432.1 - 0.078 12.8 5.6 0.39 10.6 0.4 2.6 3 0 0 3 3 3 0 Prokaryotic diacylglycerol kinase Mog1 PF04603.12 CDW53432.1 - 0.2 12.1 0.0 2.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Ran-interacting Mog1 protein Anoctamin PF04547.12 CDW53433.1 - 1.8e-44 152.4 0.4 2.1e-44 152.1 0.4 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF3021 PF11457.8 CDW53433.1 - 0.13 12.6 2.9 0.28 11.5 2.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3021) SecE PF00584.20 CDW53433.1 - 0.38 10.7 5.3 0.2 11.6 2.4 2.0 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex QVR PF17064.5 CDW53434.1 - 0.048 13.9 5.5 0.33 11.2 5.6 2.0 1 1 0 1 1 1 0 Sleepless protein Tmemb_cc2 PF10267.9 CDW53435.1 - 2.3e-70 237.8 8.2 7e-70 236.2 8.2 1.7 1 1 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein DUF4407 PF14362.6 CDW53435.1 - 0.0036 16.7 3.9 0.0036 16.7 3.9 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4407) DUF2207 PF09972.9 CDW53435.1 - 0.026 13.3 0.2 0.076 11.8 0.0 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Rootletin PF15035.6 CDW53435.1 - 0.054 13.5 14.1 0.0094 16.0 9.2 2.3 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF1474 PF07342.11 CDW53435.1 - 0.057 13.9 0.0 0.2 12.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1474) ApoO PF09769.9 CDW53435.1 - 0.084 12.8 2.5 0.83 9.6 0.1 3.0 2 1 1 3 3 3 0 Apolipoprotein O Bacillus_HBL PF05791.11 CDW53435.1 - 0.89 9.4 9.6 0.51 10.1 0.2 3.1 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) DUF4709 PF15821.5 CDW53435.1 - 1.3 9.4 11.1 0.52 10.6 3.8 3.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4709) CtIP_N PF10482.9 CDW53435.1 - 2.6 8.1 16.9 2.2 8.4 0.2 2.8 2 1 1 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain Baculo_PEP_C PF04513.12 CDW53435.1 - 8.7 6.4 8.7 1.8 8.6 2.1 2.7 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Actin PF00022.19 CDW53437.1 - 4.7e-37 127.6 0.0 2.5e-25 89.0 0.0 2.5 1 1 2 3 3 3 2 Actin RIC3 PF15361.6 CDW53438.1 - 5.9e-20 72.1 0.0 2.2e-19 70.3 0.0 1.8 2 0 0 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 EAP30 PF04157.16 CDW53438.1 - 0.0023 17.2 0.3 0.0041 16.4 0.3 1.4 1 0 0 1 1 1 1 EAP30/Vps36 family ATP-grasp_2 PF08442.10 CDW53439.1 - 2.2e-64 216.8 1.5 2.9e-64 216.4 1.5 1.2 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 CDW53439.1 - 3.1e-17 62.8 0.0 6.4e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CDW53439.1 - 1.9e-08 34.0 1.2 3e-08 33.4 1.2 1.2 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CDW53439.1 - 0.0039 17.0 0.1 0.0098 15.7 0.1 1.6 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain TPR_1 PF00515.28 CDW53440.1 - 1.3e-25 88.0 14.1 2.4e-06 27.1 1.9 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat DUF1736 PF08409.11 CDW53440.1 - 7.5e-18 64.3 2.5 2.2e-17 62.8 2.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_2 PF07719.17 CDW53440.1 - 4e-17 60.9 7.0 5.1e-06 26.2 1.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDW53440.1 - 3.6e-16 58.0 4.8 0.00063 19.8 0.8 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDW53440.1 - 4.1e-14 52.0 8.5 0.00061 19.4 0.4 4.8 2 2 3 5 5 5 4 TPR repeat TPR_17 PF13431.6 CDW53440.1 - 6e-14 51.3 13.5 0.016 15.5 0.8 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDW53440.1 - 8.7e-10 38.8 4.2 3.4e-06 27.3 1.2 4.5 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDW53440.1 - 1.4e-08 34.4 7.6 0.19 11.7 0.4 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDW53440.1 - 4.7e-08 32.5 3.4 0.093 12.8 0.2 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW53440.1 - 1.4e-07 32.0 0.1 0.17 12.6 0.0 3.5 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDW53440.1 - 7.8e-06 26.3 0.0 0.26 12.2 0.0 4.4 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW53440.1 - 9e-05 22.9 1.1 0.0095 16.4 0.7 3.5 2 1 2 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDW53440.1 - 0.00077 20.0 0.5 19 6.2 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Rapsyn_N PF10579.9 CDW53440.1 - 0.058 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region EST1_DNA_bind PF10373.9 CDW53440.1 - 0.18 11.2 0.1 0.18 11.2 0.1 2.7 2 1 1 3 3 3 0 Est1 DNA/RNA binding domain ANAPC3 PF12895.7 CDW53440.1 - 1.9 8.7 8.9 0.6 10.4 0.3 3.9 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 RRM_1 PF00076.22 CDW53441.1 - 1.9e-17 62.8 0.0 2.4e-17 62.5 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW53441.1 - 6.8e-05 22.7 0.0 8.6e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 CDW53441.1 - 9.2e-05 22.0 0.0 0.0001 21.9 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW53441.1 - 0.00037 20.5 0.0 0.00064 19.8 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif KorB_C PF06613.11 CDW53441.1 - 0.1 12.6 0.1 0.25 11.4 0.0 1.8 1 1 1 2 2 2 0 KorB C-terminal beta-barrel domain DbpA PF03880.15 CDW53441.1 - 0.1 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 DbpA RNA binding domain SET_assoc PF11767.8 CDW53441.1 - 0.14 11.8 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DUF1866 PF08952.11 CDW53441.1 - 0.15 11.9 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) Laminin_G_1 PF00054.23 CDW53441.1 - 0.2 11.9 0.0 0.31 11.3 0.0 1.3 1 0 0 1 1 1 0 Laminin G domain RRM_1 PF00076.22 CDW53442.1 - 8.9e-18 63.9 0.0 1.2e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW53442.1 - 8.6e-06 25.4 0.0 1e-05 25.1 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW53442.1 - 1.6e-05 24.9 0.0 2.4e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif CPT PF07931.12 CDW53442.1 - 0.15 11.9 0.1 0.21 11.4 0.1 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein UDPGT PF00201.18 CDW53444.1 - 4.7e-45 154.3 0.5 6e-45 154.0 0.5 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW53444.1 - 8.3e-06 25.9 0.0 1.4e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Hexokinase_2 PF03727.16 CDW53445.1 - 2.6e-78 262.7 0.0 3.8e-78 262.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CDW53445.1 - 1.2e-66 224.4 0.0 1.7e-66 224.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Bestrophin PF01062.21 CDW53446.1 - 4.9e-180 597.3 26.6 5.5e-92 308.3 7.6 2.2 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel HSR PF03172.13 CDW53446.1 - 0.00057 20.0 0.0 0.082 13.1 0.0 2.6 2 0 0 2 2 2 2 HSR domain Stap_Strp_toxin PF01123.20 CDW53446.1 - 0.11 13.4 0.0 7.7 7.4 0.0 2.7 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain Ras PF00071.22 CDW53447.1 - 1.7e-51 174.0 0.2 2.1e-51 173.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW53447.1 - 1.9e-20 73.3 0.0 3e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW53447.1 - 2.2e-08 33.7 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CDW53447.1 - 1.2e-06 28.5 0.0 0.0059 16.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CDW53447.1 - 0.0003 20.4 0.0 0.00083 19.0 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CDW53447.1 - 0.0003 20.3 0.0 0.00055 19.4 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDW53447.1 - 0.0069 15.8 0.2 0.011 15.1 0.2 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW53447.1 - 0.017 15.2 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Plant_all_beta PF10532.9 CDW53447.1 - 0.047 14.0 0.1 0.097 13.0 0.1 1.5 1 0 0 1 1 1 0 Plant specific N-all beta domain MMR_HSR1_Xtn PF16897.5 CDW53447.1 - 0.065 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CDW53447.1 - 0.18 11.3 0.2 0.65 9.5 0.2 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B LRR_8 PF13855.6 CDW53448.1 - 4.6e-38 128.8 50.0 7.2e-12 44.9 1.4 10.0 5 2 5 11 11 11 9 Leucine rich repeat PP2C PF00481.21 CDW53448.1 - 7.1e-26 91.4 0.0 1.1e-25 90.7 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 CDW53448.1 - 4.1e-22 77.9 67.2 5.3e-06 26.7 4.3 11.7 5 3 11 16 16 16 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW53448.1 - 4.9e-09 35.9 24.1 3.5e-05 23.4 2.0 5.0 2 2 3 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 CDW53448.1 - 7.8e-08 31.8 38.8 1.9 8.8 0.0 13.4 14 0 0 14 14 14 4 Leucine Rich repeat PH PF00169.29 CDW53448.1 - 0.00021 21.8 0.4 0.0015 19.0 0.0 2.6 3 0 0 3 3 3 1 PH domain LRR_5 PF13306.6 CDW53448.1 - 0.071 13.1 4.8 2.6 8.0 0.9 3.5 2 1 1 3 3 3 0 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CDW53448.1 - 0.13 12.9 58.2 0.37 11.5 0.1 14.0 13 3 0 13 13 13 0 Leucine Rich Repeat WD40 PF00400.32 CDW53449.1 - 1.9e-14 53.8 15.8 1.3e-05 25.8 0.3 6.6 7 1 1 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53449.1 - 0.00053 20.2 0.0 1.1 9.6 0.0 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW53449.1 - 0.11 11.8 0.0 3.5 6.9 0.0 2.6 1 1 0 1 1 1 0 WD40-like domain PQQ_3 PF13570.6 CDW53449.1 - 0.27 11.8 0.8 6 7.5 0.0 3.5 5 0 0 5 5 5 0 PQQ-like domain DEAD PF00270.29 CDW53450.1 - 1.5e-48 164.8 0.1 2.7e-48 164.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW53450.1 - 5.1e-30 104.1 0.0 1.9e-29 102.2 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDW53450.1 - 3.7e-06 26.3 0.1 3.7e-06 26.3 0.1 1.5 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 CDW53450.1 - 1.7e-05 24.9 0.0 4.4e-05 23.5 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CDW53450.1 - 0.025 14.2 0.0 0.069 12.8 0.0 1.6 2 0 0 2 2 2 0 SWI2/SNF2 ATPase RabGAP-TBC PF00566.18 CDW53451.1 - 4.2e-28 98.5 1.9 1.2e-27 97.0 1.9 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Rad51 PF08423.11 CDW53452.1 - 5.5e-36 124.1 0.4 2.7e-35 121.9 0.4 2.0 1 1 0 1 1 1 1 Rad51 RecA PF00154.21 CDW53452.1 - 5.4e-07 29.3 0.1 6.8e-05 22.5 0.0 2.1 2 0 0 2 2 2 2 recA bacterial DNA recombination protein AAA_25 PF13481.6 CDW53452.1 - 1.2e-06 28.3 0.0 3.1e-06 26.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 CDW53452.1 - 4.5e-06 26.2 0.4 1.6e-05 24.4 0.4 1.9 1 1 0 1 1 1 1 KaiC AAA_24 PF13479.6 CDW53452.1 - 9.2e-05 22.3 0.0 0.0011 18.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW53452.1 - 0.002 18.4 0.2 0.012 15.9 0.2 2.1 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 CDW53452.1 - 0.012 15.2 0.0 0.059 13.0 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA PF00004.29 CDW53452.1 - 0.032 14.7 0.2 0.31 11.5 0.2 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDW53452.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDW53452.1 - 0.086 13.2 0.2 0.71 10.2 0.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 CDW53452.1 - 0.13 12.8 0.0 0.34 11.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter Sec7 PF01369.20 CDW53453.1 - 3.1e-63 212.8 0.5 5.8e-63 211.9 0.5 1.5 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CDW53453.1 - 2.6e-18 66.4 6.7 4.5e-18 65.7 2.6 3.4 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 CDW53453.1 - 3.9e-08 33.1 0.4 1.6e-07 31.2 0.4 2.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 SPO22 PF08631.10 CDW53453.1 - 0.015 14.8 0.0 0.044 13.3 0.0 1.8 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF1981 PF09324.10 CDW53453.1 - 0.043 13.7 0.0 0.21 11.4 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) Rad60-SLD PF11976.8 CDW53454.1 - 5.6e-15 54.9 0.1 6.6e-15 54.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDW53454.1 - 6.8e-14 51.4 0.3 7.9e-14 51.2 0.3 1.1 1 0 0 1 1 1 1 Ubiquitin family Glyco_hydro_30C PF17189.4 CDW53454.1 - 0.044 14.0 0.4 0.052 13.8 0.4 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain Tli4_C PF18426.1 CDW53454.1 - 0.047 14.0 0.1 0.057 13.7 0.1 1.1 1 0 0 1 1 1 0 Tle cognate immunity protein 4 C-terminal domain DUF3524 PF12038.8 CDW53455.1 - 6.9e-61 205.0 0.1 8.9e-61 204.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3524) RRM_1 PF00076.22 CDW53456.1 - 4.9e-06 26.3 0.0 7.7e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) V_ATPase_I PF01496.19 CDW53458.1 - 1.8e-280 932.5 15.6 3.6e-255 848.8 9.0 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family TPK_catalytic PF04263.16 CDW53459.1 - 5.9e-23 81.2 0.0 8.3e-23 80.7 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 CDW53459.1 - 2.1e-17 62.6 0.0 3.5e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain HEAT PF02985.22 CDW53460.1 - 1.3e-23 81.0 20.1 0.00039 20.4 0.0 13.7 15 0 0 15 15 14 4 HEAT repeat HEAT_2 PF13646.6 CDW53460.1 - 3.3e-17 62.7 5.3 0.00052 20.4 0.0 8.3 7 2 1 8 8 8 4 HEAT repeats CLASP_N PF12348.8 CDW53460.1 - 3.5e-14 52.9 0.1 2.9e-05 23.7 0.0 5.2 4 1 0 5 5 5 2 CLASP N terminal HEAT_EZ PF13513.6 CDW53460.1 - 4.4e-13 49.4 26.9 0.00036 21.0 0.0 11.3 10 4 5 15 15 14 3 HEAT-like repeat Cnd1 PF12717.7 CDW53460.1 - 1.1e-08 35.3 4.0 0.084 12.9 0.0 7.1 7 1 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDW53460.1 - 3.4e-07 30.8 0.0 15 6.2 0.0 6.5 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 CDW53460.1 - 8.3e-06 24.6 8.1 0.17 10.4 0.0 5.3 5 2 2 7 7 7 2 Adaptin N terminal region Cohesin_HEAT PF12765.7 CDW53460.1 - 0.0029 17.9 6.4 29 5.1 0.2 6.8 8 0 0 8 8 8 0 HEAT repeat associated with sister chromatid cohesion IFRD PF05004.13 CDW53460.1 - 0.03 13.4 0.8 5.2 6.1 0.0 3.5 3 1 0 4 4 4 0 Interferon-related developmental regulator (IFRD) NopRA1 PF16201.5 CDW53460.1 - 0.057 13.0 4.4 2.4 7.7 0.1 4.7 5 1 0 5 5 5 0 Nucleolar pre-ribosomal-associated protein 1 MMS19_C PF12460.8 CDW53460.1 - 0.096 11.8 0.0 0.096 11.8 0.0 5.4 7 1 1 8 8 8 0 RNAPII transcription regulator C-terminal LRR_8 PF13855.6 CDW53461.1 - 8e-30 102.4 8.5 6.6e-08 32.2 0.5 5.4 2 2 3 5 5 5 5 Leucine rich repeat LRR_5 PF13306.6 CDW53461.1 - 1e-26 93.4 0.1 2e-11 43.9 0.0 3.7 3 1 1 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 CDW53461.1 - 3e-09 37.0 4.1 0.013 15.9 0.8 5.0 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW53461.1 - 4.2e-05 23.1 0.4 0.0016 18.0 0.1 2.6 1 1 1 3 3 3 1 Leucine-rich repeat LRRNT PF01462.18 CDW53461.1 - 0.00043 19.8 1.7 0.00043 19.8 1.7 2.2 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain RAMP PF04901.13 CDW53461.1 - 0.045 13.8 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 Receptor activity modifying family LRR_1 PF00560.33 CDW53461.1 - 0.24 12.1 10.7 20 6.3 0.1 6.0 5 1 0 5 5 5 0 Leucine Rich Repeat Ribosomal_S2 PF00318.20 CDW53462.1 - 2.2e-27 95.7 0.1 1.7e-14 53.6 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 CDW53462.1 - 5.5e-07 30.9 7.1 1.1e-06 30.0 7.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus RabGAP-TBC PF00566.18 CDW53463.1 - 2.9e-49 167.6 0.0 4.6e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SM-ATX PF14438.6 CDW53464.1 - 7.8e-11 42.0 0.0 1.7e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.13 CDW53464.1 - 0.0023 18.4 3.2 0.17 12.4 0.2 2.5 2 0 0 2 2 2 2 LsmAD domain 2OG-FeII_Oxy_2 PF13532.6 CDW53465.1 - 2.8e-27 96.2 0.1 3.3e-27 95.9 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FTO_NTD PF12933.7 CDW53465.1 - 0.11 11.7 0.1 2.1 7.5 0.0 2.0 1 1 1 2 2 2 0 FTO catalytic domain Ribosomal_L38e PF01781.18 CDW53466.1 - 1.6e-33 114.6 1.3 1.7e-33 114.5 1.3 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family zf-CCCH PF00642.24 CDW53467.1 - 4e-12 45.7 33.8 3.2e-06 26.9 0.5 5.4 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDW53467.1 - 1.4e-11 44.0 43.8 1.1e-06 28.5 2.6 6.3 5 1 0 5 5 5 4 Zinc finger domain Torus PF16131.5 CDW53467.1 - 3.1e-11 43.9 28.4 0.00038 21.1 0.6 5.4 1 1 4 5 5 5 4 Torus domain zf-CCHC PF00098.23 CDW53467.1 - 3.3e-09 36.4 17.3 1.2e-05 25.2 3.7 3.5 3 0 0 3 3 3 2 Zinc knuckle zf-CCCH_3 PF15663.5 CDW53467.1 - 1.3e-07 31.8 28.0 3.2e-07 30.5 10.4 3.4 2 1 1 3 3 3 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 CDW53467.1 - 4.9e-06 26.2 0.3 4.9e-06 26.2 0.3 4.9 5 0 0 5 5 5 3 CCCH-type zinc finger zf-CCHC_3 PF13917.6 CDW53467.1 - 0.0027 17.6 2.7 0.22 11.5 1.1 2.7 2 0 0 2 2 2 1 Zinc knuckle Cys_rich_KTR PF14205.6 CDW53467.1 - 0.025 14.4 1.0 0.092 12.6 1.0 2.0 1 0 0 1 1 1 0 Cysteine-rich KTR zf-CCHC_4 PF14392.6 CDW53467.1 - 0.52 10.1 9.2 2.3 8.0 2.2 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 CDW53467.1 - 2.9 7.7 12.8 0.54 10.0 2.2 2.9 2 0 0 2 2 2 0 C2H2 zinc-finger zf-CCCH_2 PF14608.6 CDW53467.1 - 3 8.4 46.0 0.28 11.7 6.1 6.2 6 1 0 6 6 6 0 RNA-binding, Nab2-type zinc finger Ig_3 PF13927.6 CDW53468.1 - 4.3e-28 97.7 0.0 3.9e-14 53.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 CDW53468.1 - 8.4e-27 93.1 0.0 2.9e-13 49.7 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 CDW53468.1 - 9.6e-21 73.8 0.0 1.8e-11 44.0 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 CDW53468.1 - 2e-19 69.7 0.0 3.9e-09 36.7 0.0 2.7 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 CDW53468.1 - 1.8e-10 40.9 0.1 0.0015 18.7 0.0 3.5 2 2 0 2 2 2 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW53468.1 - 0.00011 22.2 0.0 0.34 11.0 0.0 2.7 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain BBIP10 PF14777.6 CDW53469.1 - 8.5e-17 60.5 4.4 1e-16 60.2 4.4 1.1 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 ALS2CR11 PF15729.5 CDW53469.1 - 0.015 14.5 0.2 0.016 14.4 0.2 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 PAX PF00292.18 CDW53470.1 - 2.4e-71 237.5 0.7 4.5e-71 236.6 0.7 1.5 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 CDW53470.1 - 7.4e-22 77.0 3.7 1.7e-21 75.8 3.7 1.7 1 0 0 1 1 1 1 Homeodomain HTH_23 PF13384.6 CDW53470.1 - 9.4e-05 22.1 0.0 0.00063 19.5 0.0 2.5 3 0 0 3 3 3 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 CDW53470.1 - 0.0039 16.8 0.0 0.015 14.9 0.0 2.0 2 0 0 2 2 2 1 InsA C-terminal domain Homeobox_KN PF05920.11 CDW53470.1 - 0.05 13.5 0.8 0.17 11.9 0.1 2.2 2 0 0 2 2 2 0 Homeobox KN domain HTH_28 PF13518.6 CDW53470.1 - 0.07 13.3 4.0 0.2 11.8 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain DUF872 PF05915.12 CDW53471.1 - 1.9e-20 73.2 0.3 2.1e-20 73.0 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) YrhK PF14145.6 CDW53471.1 - 0.012 15.4 0.6 0.026 14.4 0.2 1.7 2 0 0 2 2 2 0 YrhK-like protein DUF3185 PF11381.8 CDW53471.1 - 0.027 14.5 3.7 0.47 10.5 0.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3185) Phage_holin_3_6 PF07332.11 CDW53471.1 - 0.051 13.6 0.2 0.067 13.2 0.2 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III RseC_MucC PF04246.12 CDW53471.1 - 0.43 10.5 1.3 0.55 10.2 1.3 1.1 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Saf_2TM PF18303.1 CDW53471.1 - 5.7 6.5 6.7 6.8 6.3 1.1 2.1 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain RINGv PF12906.7 CDW53473.1 - 2.8e-11 43.4 5.4 6.2e-11 42.2 5.4 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CDW53473.1 - 1.4 9.3 9.2 0.11 12.8 4.1 1.9 2 0 0 2 2 2 0 Ring finger domain Collagen PF01391.18 CDW53474.1 - 7.8e-23 80.0 75.6 2.2e-08 33.7 21.8 4.2 4 0 0 4 4 4 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW53474.1 - 1e-07 31.9 0.5 1.4e-07 31.4 0.5 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Collagen PF01391.18 CDW53475.1 - 2e-26 91.5 55.3 1.5e-09 37.5 7.5 3.9 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Collagen PF01391.18 CDW53476.1 - 2.9e-24 84.6 84.8 9.1e-10 38.2 28.7 4.0 2 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Collagen PF01391.18 CDW53477.1 - 2.1e-25 88.3 110.0 1.7e-09 37.3 37.1 4.0 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW53477.1 - 7.4e-24 83.6 1.1 9.1e-24 83.3 1.1 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Oleosin PF01277.17 CDW53477.1 - 0.043 13.6 0.1 0.062 13.1 0.1 1.1 1 0 0 1 1 1 0 Oleosin Collagen PF01391.18 CDW53478.1 - 8.5e-23 79.9 78.2 6.5e-08 32.2 26.3 4.2 3 1 1 4 4 4 4 Collagen triple helix repeat (20 copies) FIBP PF05427.11 CDW53479.1 - 9.9e-92 308.0 1.0 1.2e-91 307.7 1.0 1.0 1 0 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) Forkhead PF00250.18 CDW53480.1 - 2.5e-34 117.4 0.0 4.1e-34 116.7 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Collagen PF01391.18 CDW53481.1 - 1.4e-23 82.4 98.6 1e-06 28.4 31.3 4.4 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW53481.1 - 1.4e-07 31.5 0.3 1.9e-07 31.0 0.3 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Guanylate_kin PF00625.21 CDW53482.1 - 6.8e-39 133.4 2.0 9.3e-30 103.7 0.6 2.5 2 0 0 2 2 2 2 Guanylate kinase VGCC_beta4Aa_N PF12052.8 CDW53482.1 - 0.03 14.4 1.2 0.099 12.8 1.2 2.0 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal PDH PF02153.17 CDW53482.1 - 0.068 12.2 0.2 0.12 11.4 0.2 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase STb_secrete PF09075.10 CDW53483.1 - 0.83 9.8 3.3 82 3.4 0.2 3.4 2 1 1 3 3 3 0 Heat-stable enterotoxin B, secretory RGS PF00615.19 CDW53484.1 - 1.6e-60 202.5 17.7 1e-32 112.8 7.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain RGS-like PF09128.11 CDW53484.1 - 5.5e-10 39.3 1.6 0.00014 21.6 0.1 2.1 2 0 0 2 2 2 2 Regulator of G protein signalling-like domain CNOT1_CAF1_bind PF16415.5 CDW53484.1 - 0.00096 18.6 0.1 0.00096 18.6 0.1 1.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Thioredoxin_12 PF18400.1 CDW53484.1 - 0.18 11.6 2.7 0.51 10.1 0.7 2.2 2 0 0 2 2 2 0 Thioredoxin-like domain DUF1104 PF06518.11 CDW53484.1 - 1.6 9.2 5.8 0.32 11.4 0.3 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1104) Glycos_transf_1 PF00534.20 CDW53486.1 - 1.9e-32 112.1 0.0 2.5e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDW53486.1 - 4e-14 53.2 0.0 5.9e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CDW53486.1 - 0.04 14.3 0.0 0.077 13.4 0.0 1.5 1 1 0 1 1 1 0 Glycosyl transferases group 1 C5-epim_C PF06662.13 CDW53487.1 - 5.7e-67 224.9 0.0 8.5e-67 224.3 0.0 1.2 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus AA_kinase PF00696.28 CDW53488.1 - 1.6e-41 142.5 2.2 2.8e-41 141.7 0.6 2.0 2 0 0 2 2 2 1 Amino acid kinase family Aldedh PF00171.22 CDW53488.1 - 3.2e-15 55.6 4.2 1.2e-12 47.1 1.2 3.1 1 1 1 2 2 2 2 Aldehyde dehydrogenase family DUF3731 PF12531.8 CDW53488.1 - 0.076 12.8 0.4 0.24 11.2 0.1 1.8 2 0 0 2 2 2 0 DNA-K related protein DIT1_PvcA PF05141.12 CDW53488.1 - 0.096 12.1 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein SCAMP PF04144.13 CDW53489.1 - 4.1e-57 193.3 16.1 5e-57 193.0 16.1 1.1 1 0 0 1 1 1 1 SCAMP family Prominin PF05478.11 CDW53489.1 - 0.59 8.0 4.0 0.94 7.4 4.0 1.2 1 0 0 1 1 1 0 Prominin DUF5346 PF17281.2 CDW53490.1 - 1.6e-47 159.8 23.9 3.8e-47 158.5 23.9 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5346) RNA_pol_Rpb2_1 PF04563.15 CDW53492.1 - 3.9e-29 101.6 0.0 4.4e-29 101.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CDW53492.1 - 7.3e-09 35.5 0.0 9.9e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Ocnus PF05005.15 CDW53493.1 - 7.5e-35 119.3 0.3 8.6e-35 119.1 0.3 1.0 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) Nuc_sug_transp PF04142.15 CDW53494.1 - 2.2e-96 322.7 15.8 2.6e-96 322.5 15.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 CDW53494.1 - 1.4e-08 34.3 17.4 1.7e-08 34.0 16.9 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDW53494.1 - 2.8e-05 24.3 31.8 0.00023 21.4 10.3 3.2 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 CDW53494.1 - 0.00024 20.2 1.9 0.00024 20.2 1.9 2.1 4 0 0 4 4 4 1 CRT-like, chloroquine-resistance transporter-like Lig_chan-Glu_bd PF10613.9 CDW53495.1 - 3.8e-06 27.1 0.0 8.7e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 CDW53495.1 - 7.3e-05 22.3 0.0 0.00011 21.7 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ASXH PF13919.6 CDW53496.1 - 7.6e-09 35.7 0.1 8.8e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 Asx homology domain DUF1356 PF07092.12 CDW53496.1 - 0.039 13.2 0.0 0.06 12.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1356) PDZ_1 PF12812.7 CDW53496.1 - 0.11 12.6 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 PDZ-like domain CagY_M PF07337.11 CDW53496.1 - 0.14 11.8 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 DC-EC Repeat Oxidored_q6 PF01058.22 CDW53497.1 - 7.1e-24 84.1 0.1 9.6e-24 83.7 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit RMI1_N PF08585.12 CDW53498.1 - 2e-22 80.1 0.0 3.8e-21 75.8 0.0 2.2 1 1 0 1 1 1 1 RecQ mediated genome instability protein RMI1_C PF16099.5 CDW53498.1 - 9.1e-17 61.2 0.0 1.7e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold Syja_N PF02383.18 CDW53499.1 - 1e-76 258.3 0.2 1.3e-76 257.9 0.2 1.1 1 0 0 1 1 1 1 SacI homology domain GDP_Man_Dehyd PF16363.5 CDW53500.1 - 1.8e-54 185.4 0.0 2.1e-54 185.2 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDW53500.1 - 1.6e-52 178.4 0.0 1.9e-52 178.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CDW53500.1 - 6.2e-16 58.2 0.0 9.1e-16 57.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDW53500.1 - 5.6e-14 52.0 0.0 3.2e-13 49.5 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDW53500.1 - 1.4e-10 40.7 0.0 2e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CDW53500.1 - 1.4e-08 34.2 0.0 8.1e-07 28.5 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CDW53500.1 - 6.5e-07 29.4 0.0 3.2e-06 27.2 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CDW53500.1 - 0.0016 17.9 0.0 0.0037 16.7 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CDW53500.1 - 0.0087 16.0 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 KR domain YchF-GTPase_C PF06071.13 CDW53501.1 - 4.4e-38 129.3 2.7 5.3e-38 129.1 1.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CDW53501.1 - 5.6e-21 74.8 0.0 3.3e-20 72.3 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW53501.1 - 6.1e-07 29.1 0.0 1.3e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 CDW53501.1 - 0.00093 19.2 0.0 0.0024 17.9 0.0 1.7 1 0 0 1 1 1 1 TGS domain Roc PF08477.13 CDW53501.1 - 0.012 15.9 0.0 2.4 8.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 CDW53501.1 - 0.015 14.3 0.0 0.034 13.1 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ras PF00071.22 CDW53502.1 - 6.7e-29 100.6 0.4 1e-28 100.0 0.4 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW53502.1 - 6.8e-07 29.5 0.5 2.2e-06 27.9 0.1 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW53502.1 - 0.0012 18.4 0.1 0.0017 17.8 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family IMS PF00817.20 CDW53502.1 - 0.028 14.4 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 impB/mucB/samB family AAA_22 PF13401.6 CDW53502.1 - 0.036 14.3 0.0 0.26 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CDW53502.1 - 0.052 13.6 0.6 1.2 9.2 0.1 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain PRMT5 PF05185.16 CDW53503.1 - 3.5e-62 209.3 0.0 5.7e-62 208.6 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 CDW53503.1 - 7.2e-46 156.3 2.1 1.1e-45 155.7 2.1 1.2 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 CDW53503.1 - 2.5e-06 26.9 0.0 6.6e-06 25.5 0.0 1.6 1 1 0 1 1 1 1 PRMT5 TIM barrel domain Met_10 PF02475.16 CDW53503.1 - 0.005 16.6 0.1 0.0077 16.0 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.6 CDW53503.1 - 0.084 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 CDW53503.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Innexin PF00876.18 CDW53504.1 - 2e-107 359.5 16.0 2.4e-107 359.3 16.0 1.0 1 0 0 1 1 1 1 Innexin Innexin PF00876.18 CDW53505.1 - 2.8e-120 401.8 24.2 1.8e-118 395.8 24.2 2.0 1 1 0 1 1 1 1 Innexin Hormone_recep PF00104.30 CDW53506.1 - 3.8e-15 56.0 0.2 6.9e-15 55.2 0.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor WD40 PF00400.32 CDW53508.1 - 5.4e-12 46.0 11.7 0.026 15.4 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53508.1 - 5.3e-07 29.8 1.4 0.74 10.2 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW53508.1 - 1.9e-05 23.8 1.4 0.032 13.2 0.2 3.0 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein rve_3 PF13683.6 CDW53509.1 - 0.11 12.3 0.0 0.31 10.8 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain BTB PF00651.31 CDW53510.1 - 1.3e-24 86.6 0.0 2.7e-24 85.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.25 CDW53511.1 - 1.4e-32 113.1 0.2 2.2e-32 112.5 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53511.1 - 2.7e-18 66.2 0.1 4e-18 65.6 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.16 CDW53511.1 - 1.3e-14 54.0 0.0 5e-14 52.1 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW53511.1 - 4.4e-11 43.2 0.8 1.2e-10 41.8 0.1 2.1 2 0 0 2 2 2 1 Immunoglobulin domain fn3 PF00041.21 CDW53511.1 - 2.6e-10 40.5 0.0 5.4e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Ig_2 PF13895.6 CDW53511.1 - 1.5e-08 34.9 0.1 3.4e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 CDW53511.1 - 1e-06 28.8 0.1 4.9e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain Kinase-like PF14531.6 CDW53511.1 - 0.0035 16.7 0.1 0.0073 15.7 0.1 1.5 1 0 0 1 1 1 1 Kinase-like GDC-P PF02347.16 CDW53512.1 - 0.00042 19.3 0.0 0.0011 17.9 0.0 1.6 2 0 0 2 2 2 1 Glycine cleavage system P-protein Aminotran_5 PF00266.19 CDW53512.1 - 0.0027 16.7 0.0 0.004 16.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V PDH PF02153.17 CDW53512.1 - 0.014 14.4 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Prephenate dehydrogenase Beta_elim_lyase PF01212.21 CDW53512.1 - 0.017 14.4 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase Metallophos PF00149.28 CDW53513.1 - 2.1e-35 123.1 0.2 2.8e-35 122.7 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDW53513.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain SLC3A2_N PF16028.5 CDW53514.1 - 3.4e-24 84.2 1.7 6.4e-24 83.3 1.7 1.4 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus Alpha-amylase PF00128.24 CDW53514.1 - 4.3e-20 72.5 0.0 3.5e-18 66.3 0.0 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Robl_LC7 PF03259.17 CDW53515.1 - 4.8e-15 55.1 0.0 5.2e-15 55.0 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 CDW53515.1 - 0.022 14.7 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 Motile_Sperm PF00635.26 CDW53516.1 - 2.2e-16 59.6 0.2 2.7e-16 59.4 0.2 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Creatinase_N_2 PF16189.5 CDW53517.1 - 8.1e-48 162.6 0.0 1.5e-47 161.7 0.0 1.5 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CDW53517.1 - 1.8e-45 155.2 0.0 3.1e-45 154.4 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 CDW53517.1 - 2.5e-20 72.3 0.2 1e-19 70.3 0.2 2.1 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 CDW53517.1 - 1.3e-13 51.8 0.0 1.5e-08 35.3 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Ldl_recept_a PF00057.18 CDW53518.1 - 2.6e-278 897.9 555.6 2.1e-12 47.0 11.0 33.7 32 0 0 32 32 32 32 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 CDW53518.1 - 2.2e-81 268.1 48.3 5.3e-10 39.6 0.5 27.8 31 0 0 31 31 31 16 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 CDW53518.1 - 3.8e-52 174.3 258.6 1.2e-10 41.5 7.5 19.4 18 0 0 18 18 18 13 Coagulation Factor Xa inhibitory site DUF5050 PF16472.5 CDW53518.1 - 4.3e-25 88.5 0.0 3.6e-05 23.2 0.0 9.6 11 1 0 11 11 11 7 Domain of unknown function (DUF5050) cEGF PF12662.7 CDW53518.1 - 1.6e-19 69.5 78.4 3.4e-07 30.1 1.6 14.5 12 0 0 12 12 12 6 Complement Clr-like EGF-like EGF_CA PF07645.15 CDW53518.1 - 2.3e-11 43.7 23.3 2.8e-08 33.8 7.7 31.1 31 7 10 41 41 41 5 Calcium-binding EGF domain SGL PF08450.12 CDW53518.1 - 1.3e-06 28.2 4.7 1.2 8.7 0.3 8.2 9 2 0 9 9 9 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 CDW53518.1 - 0.55 10.5 2.3 45 4.3 0.0 5.2 8 0 0 8 8 8 0 Arylesterase Ldl_recept_a PF00057.18 CDW53519.1 - 3e-10 40.1 11.8 3.7e-10 39.9 11.8 1.1 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Jun PF03957.13 CDW53521.1 - 2e-17 63.8 8.3 3.9e-17 62.9 7.5 2.0 1 1 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.21 CDW53521.1 - 4.9e-14 52.2 9.8 8.7e-14 51.4 9.8 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 CDW53521.1 - 2.7e-08 34.2 4.2 6.9e-08 32.9 4.2 1.7 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 CDW53521.1 - 4.4e-06 26.7 7.6 8.9e-06 25.7 7.6 1.5 1 0 0 1 1 1 1 Basic region leucine zipper TPR_MLP1_2 PF07926.12 CDW53521.1 - 0.077 13.1 0.9 0.18 11.8 0.9 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DB PF01682.19 CDW53522.1 - 3.8e-15 56.0 15.2 5.2e-15 55.6 15.2 1.2 1 0 0 1 1 1 1 DB module Neur_chan_LBD PF02931.23 CDW53523.1 - 9e-72 241.0 3.0 1.2e-71 240.6 3.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW53523.1 - 8.8e-58 196.2 0.4 1.1e-57 195.8 0.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Tetraspanin PF00335.20 CDW53523.1 - 0.056 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Tetraspanin family SNF PF00209.18 CDW53524.1 - 1.6e-185 617.7 36.2 2e-185 617.5 36.2 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Hist_deacetyl PF00850.19 CDW53525.1 - 2.9e-67 227.3 0.2 4.5e-67 226.7 0.2 1.4 2 0 0 2 2 2 1 Histone deacetylase domain Ribosomal_60s PF00428.19 CDW53526.1 - 9e-23 80.7 0.8 1.1e-22 80.4 0.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein AMP-binding PF00501.28 CDW53526.1 - 0.11 11.0 0.2 0.12 10.9 0.2 1.0 1 0 0 1 1 1 0 AMP-binding enzyme wnt PF00110.19 CDW53527.1 - 4.8e-98 328.6 32.5 1.6e-79 267.7 5.0 3.1 3 0 0 3 3 3 3 wnt family PAX PF00292.18 CDW53528.1 - 3.5e-56 188.5 0.9 5.9e-56 187.8 0.9 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 CDW53528.1 - 3.8e-06 26.5 0.0 8.3e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 CDW53528.1 - 0.0022 18.5 0.2 1.1 10.0 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.6 CDW53528.1 - 0.012 15.7 0.2 0.035 14.2 0.0 1.9 3 0 0 3 3 3 0 Helix-turn-helix domain RhoGAP PF00620.27 CDW53529.1 - 1.7e-42 144.8 1.1 5.8e-42 143.1 0.0 2.4 2 1 0 2 2 2 1 RhoGAP domain C1_1 PF00130.22 CDW53529.1 - 5e-05 23.1 10.1 0.00016 21.5 10.1 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FCH PF00611.23 CDW53529.1 - 0.001 19.3 2.3 0.0033 17.7 0.2 3.0 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain zf-C5HC2 PF02928.16 CDW53529.1 - 0.39 11.1 10.3 1.5 9.3 10.3 2.1 1 0 0 1 1 1 0 C5HC2 zinc finger DUF4200 PF13863.6 CDW53529.1 - 2.1 8.8 21.0 1.6 9.2 17.7 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) PCAF_N PF06466.11 CDW53530.1 - 2.8e-44 151.6 1.4 3.1e-44 151.5 0.3 1.5 2 0 0 2 2 2 1 PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain PF00439.25 CDW53530.1 - 1.1e-21 76.7 0.0 2.1e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 CDW53530.1 - 1e-05 25.7 0.1 2.2e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW53530.1 - 0.00014 21.8 0.1 0.0003 20.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW53530.1 - 0.0015 18.9 0.2 0.0042 17.5 0.2 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Metallophos PF00149.28 CDW53531.1 - 5.8e-08 33.5 0.0 8.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDW53531.1 - 0.0036 17.5 0.0 0.016 15.4 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain NOG1 PF06858.14 CDW53531.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) Med8 PF10232.9 CDW53532.1 - 7.9e-45 153.3 2.4 8.9e-45 153.1 2.4 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 QIL1 PF15884.5 CDW53532.1 - 0.1 13.2 0.9 0.92 10.1 0.2 2.3 1 1 1 2 2 2 0 MICOS complex subunit MIC13, QIL1 PCI PF01399.27 CDW53533.1 - 2.9e-15 56.6 0.8 3.4e-14 53.2 0.0 3.2 4 2 0 4 4 4 1 PCI domain LUC7 PF03194.15 CDW53533.1 - 0.00063 19.5 2.1 0.0012 18.6 2.1 1.5 1 0 0 1 1 1 1 LUC7 N_terminus RPN5_C PF18098.1 CDW53533.1 - 0.0027 17.8 0.1 0.0098 16.0 0.1 2.0 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain DDA1 PF10172.9 CDW53533.1 - 0.11 12.8 0.6 1.2 9.5 0.1 2.5 2 0 0 2 2 2 0 Det1 complexing ubiquitin ligase Lectin_C PF00059.21 CDW53534.1 - 5.3e-11 43.2 0.2 6.7e-11 42.9 0.2 1.1 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 CDW53534.1 - 4.8e-05 23.1 0.0 6.5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 UL45 protein, carbohydrate-binding C-type lectin-like DUF974 PF06159.13 CDW53535.1 - 3.5e-42 144.9 0.0 1.7e-41 142.7 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF974) Transglut_C PF00927.22 CDW53535.1 - 0.0094 16.1 0.1 0.078 13.1 0.0 2.3 2 0 0 2 2 2 1 Transglutaminase family, C-terminal ig like domain Trs65 PF12735.7 CDW53535.1 - 0.024 14.1 0.0 2.2 7.6 0.0 2.3 1 1 1 2 2 2 0 TRAPP trafficking subunit Trs65 Prot_ATP_OB_N PF17758.1 CDW53535.1 - 0.21 11.3 0.2 0.57 9.9 0.0 1.8 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain Sin_N PF04801.13 CDW53536.1 - 5.4e-41 141.2 0.0 1.4e-40 139.8 0.0 1.7 1 1 0 1 1 1 1 Sin-like protein conserved region DUF5370 PF17340.2 CDW53536.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5370) EF-hand_1 PF00036.32 CDW53538.1 - 7.8e-35 115.8 12.1 1.2e-09 37.0 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDW53538.1 - 5e-31 107.0 4.8 3.3e-15 56.3 0.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDW53538.1 - 6.2e-28 96.4 11.5 1.3e-12 47.3 0.4 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CDW53538.1 - 1.1e-25 87.3 12.3 4.9e-09 35.4 0.1 4.5 4 1 1 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 CDW53538.1 - 1.1e-22 78.4 10.0 3.6e-07 29.4 0.4 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CDW53538.1 - 1.4e-13 50.9 0.1 4.1e-08 33.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 CDW53538.1 - 6.2e-06 26.5 0.2 0.091 13.1 0.1 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 CDW53538.1 - 9.2e-05 22.4 1.6 0.86 9.5 0.0 3.3 1 1 2 3 3 3 2 Caleosin related protein EF-hand_4 PF12763.7 CDW53538.1 - 0.00015 21.7 3.4 0.41 10.6 0.6 2.9 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CDW53538.1 - 0.0022 18.2 6.3 0.3 11.3 0.1 3.5 2 1 3 5 5 4 3 Dockerin type I domain RNA_pol_Rpb4 PF03874.16 CDW53538.1 - 0.0027 18.0 1.2 1.6 9.1 0.1 2.9 2 1 1 3 3 3 1 RNA polymerase Rpb4 UPF0154 PF03672.13 CDW53538.1 - 0.0028 17.6 0.1 0.39 10.8 0.0 2.6 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) DUF4497 PF14924.6 CDW53538.1 - 0.0063 17.0 0.0 2.5 8.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4497) AAA_assoc_C PF09821.9 CDW53538.1 - 0.026 15.1 0.2 0.67 10.5 0.1 2.3 2 0 0 2 2 2 0 C-terminal AAA-associated domain DUF3427 PF11907.8 CDW53538.1 - 0.038 13.2 0.1 5.9 6.1 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3427) EF-hand_14 PF17959.1 CDW53538.1 - 0.039 14.3 0.8 4.5 7.7 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain EF-hand_11 PF08976.11 CDW53538.1 - 0.053 14.4 0.1 3.1 8.7 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain EFhand_Ca_insen PF08726.10 CDW53538.1 - 0.069 13.3 0.1 0.18 11.9 0.1 1.8 1 0 0 1 1 1 0 Ca2+ insensitive EF hand dCache_2 PF08269.11 CDW53538.1 - 0.07 12.3 0.1 0.76 8.9 0.1 2.2 1 1 1 2 2 2 0 Cache domain SurA_N_2 PF13623.6 CDW53538.1 - 0.2 11.5 3.2 0.53 10.1 1.1 2.4 1 1 2 3 3 3 0 SurA N-terminal domain PB1 PF00564.24 CDW53538.1 - 1.4 8.9 3.9 24 4.9 0.1 3.2 2 2 1 3 3 3 0 PB1 domain DUF3008 PF11450.8 CDW53538.1 - 3.4 7.9 5.6 2.2 8.5 1.7 2.3 2 1 1 3 3 3 0 Protein of unknwon function (DUF3008) RhoGEF PF00621.20 CDW53539.1 - 6.8e-16 59.0 2.4 6.8e-16 59.0 2.4 1.9 2 0 0 2 2 2 1 RhoGEF domain IQ_SEC7_PH PF16453.5 CDW53539.1 - 0.0025 17.8 0.4 0.023 14.6 0.0 2.4 2 0 0 2 2 2 1 PH domain PH PF00169.29 CDW53539.1 - 0.051 14.1 0.2 0.23 12.0 0.2 2.2 1 0 0 1 1 1 0 PH domain TRAPP PF04051.16 CDW53540.1 - 1e-30 106.4 0.1 1.2e-30 106.1 0.1 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Tetraspanin PF00335.20 CDW53542.1 - 1.3 8.7 10.5 1.2 8.8 2.3 2.1 2 0 0 2 2 2 0 Tetraspanin family HECT PF00632.25 CDW53543.1 - 7.2e-95 318.0 0.3 1e-94 317.5 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 CDW53543.1 - 4.5e-46 154.6 21.0 1.3e-12 47.5 2.4 4.7 4 0 0 4 4 4 4 WW domain DUF4624 PF15417.6 CDW53543.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4624) PAN_4 PF14295.6 CDW53544.1 - 0.025 14.5 20.9 0.2 11.6 1.0 5.1 5 0 0 5 5 5 0 PAN domain PAN_3 PF08277.12 CDW53544.1 - 0.029 14.2 23.1 0.73 9.7 0.2 6.1 5 1 0 5 5 5 0 PAN-like domain Sulfatase PF00884.23 CDW53544.1 - 0.051 13.0 0.0 0.53 9.6 0.0 2.1 2 0 0 2 2 2 0 Sulfatase MANEC PF07502.14 CDW53544.1 - 1.1 9.5 28.9 0.35 11.2 0.6 5.6 5 0 0 5 5 5 0 MANEC domain DUF3592 PF12158.8 CDW53545.1 - 0.0068 16.5 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3592) EGF PF00008.27 CDW53545.1 - 0.0094 16.2 12.8 0.48 10.8 5.4 2.9 2 0 0 2 2 2 2 EGF-like domain DUF4834 PF16118.5 CDW53545.1 - 0.68 10.9 4.0 6.4 7.8 4.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) EGF_2 PF07974.13 CDW53545.1 - 3.2 8.2 20.1 4.5 7.7 3.4 2.8 2 0 0 2 2 2 0 EGF-like domain cEGF PF12662.7 CDW53545.1 - 4.1 7.4 10.5 1.5 8.8 1.3 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_3 PF12947.7 CDW53545.1 - 5.9 7.2 12.3 24 5.3 4.1 2.8 1 1 1 2 2 2 0 EGF domain Laminin_EGF PF00053.24 CDW53545.1 - 6.9 6.9 17.3 69 3.7 5.9 2.7 1 1 1 2 2 2 0 Laminin EGF domain Kazal_2 PF07648.15 CDW53546.1 - 2.7e-53 177.9 96.1 7.2e-10 38.8 4.7 9.7 9 0 0 9 9 9 7 Kazal-type serine protease inhibitor domain Laminin_G_2 PF02210.24 CDW53546.1 - 4.5e-27 95.1 0.5 1.2e-12 48.5 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 CDW53546.1 - 7.8e-26 90.8 0.1 1.8e-14 54.1 0.0 2.3 2 0 0 2 2 2 2 Laminin G domain Kazal_1 PF00050.21 CDW53546.1 - 1.5e-25 88.9 112.6 1.4e-06 28.2 8.5 9.0 10 0 0 10 10 10 7 Kazal-type serine protease inhibitor domain NtA PF03146.15 CDW53546.1 - 5.3e-17 61.7 0.1 2.1e-16 59.8 0.0 2.0 2 0 0 2 2 2 1 Agrin NtA domain Laminin_EGF PF00053.24 CDW53546.1 - 1.7e-13 50.4 34.0 1.5e-09 37.8 13.5 9.5 10 3 1 11 11 11 2 Laminin EGF domain Laminin_G_3 PF13385.6 CDW53546.1 - 0.0014 18.8 0.2 1.9 8.6 0.0 2.3 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily DIX PF00778.17 CDW53547.1 - 4e-54 180.4 2.8 2.7e-28 97.6 0.1 3.4 2 1 0 2 2 2 2 DIX domain Collagen PF01391.18 CDW53547.1 - 1.8e-38 130.1 159.1 5.1e-08 32.6 27.4 8.3 4 2 2 6 6 6 6 Collagen triple helix repeat (20 copies) Dishevelled PF02377.15 CDW53547.1 - 1.4e-18 67.9 23.8 1.6e-17 64.4 22.6 2.7 2 1 0 2 2 2 1 Dishevelled specific domain PDZ PF00595.24 CDW53547.1 - 1.9e-18 66.6 0.8 3.5e-18 65.7 0.8 1.5 1 0 0 1 1 1 1 PDZ domain DEP PF00610.21 CDW53547.1 - 9.9e-15 54.4 0.0 1.9e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Col_cuticle_N PF01484.17 CDW53547.1 - 2e-06 27.7 4.5 0.00035 20.6 0.1 2.5 2 0 0 2 2 2 2 Nematode cuticle collagen N-terminal domain PDZ_6 PF17820.1 CDW53547.1 - 1.3e-05 24.9 0.1 3.2e-05 23.7 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW53547.1 - 0.012 15.9 0.1 0.026 14.9 0.1 1.5 1 0 0 1 1 1 0 PDZ domain DNA_pol_B PF00136.21 CDW53548.1 - 2.2e-88 297.0 0.0 2.7e-81 273.6 0.0 2.1 1 1 1 2 2 2 2 DNA polymerase family B zf-C4pol PF14260.6 CDW53548.1 - 7.2e-10 39.2 6.7 1.8e-09 37.9 6.7 1.7 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta Peptidase_C74 PF12387.8 CDW53548.1 - 0.0026 17.3 0.0 0.007 15.9 0.0 1.7 2 0 0 2 2 2 1 Pestivirus NS2 peptidase T3SS_needle_E PF08988.10 CDW53548.1 - 0.58 10.3 1.8 49 4.2 0.0 3.1 4 0 0 4 4 4 0 Type III secretion system, cytoplasmic E component of needle KH_1 PF00013.29 CDW53550.1 - 0.0038 17.0 0.1 0.014 15.2 0.0 2.0 2 0 0 2 2 2 1 KH domain YidC_periplas PF14849.6 CDW53550.1 - 0.052 13.4 0.0 9.1 6.1 0.0 2.4 2 0 0 2 2 2 0 YidC periplasmic domain FR47 PF08445.10 CDW53551.1 - 1.3e-07 31.5 0.0 1.8e-06 27.8 0.1 2.1 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_1 PF00583.25 CDW53551.1 - 6.4e-07 29.6 0.0 8.3e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW53551.1 - 1.6e-06 28.1 0.0 3.4e-05 23.8 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDW53551.1 - 0.0002 22.1 0.0 0.00025 21.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW53551.1 - 0.00043 20.6 0.0 0.00067 20.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 CDW53551.1 - 0.0055 16.3 0.0 0.012 15.2 0.0 1.5 2 0 0 2 2 2 1 GNAT acetyltransferase Acetyltransf_9 PF13527.7 CDW53551.1 - 0.0071 16.4 0.0 0.33 11.0 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDW53551.1 - 0.017 15.3 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 CDW53551.1 - 0.088 12.9 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Rhodanese PF00581.20 CDW53552.1 - 2.8e-27 95.3 0.0 3.7e-12 46.7 0.0 2.5 2 0 0 2 2 2 2 Rhodanese-like domain DnaJ PF00226.31 CDW53552.1 - 9.8e-17 60.8 3.6 2.6e-16 59.5 3.6 1.8 1 0 0 1 1 1 1 DnaJ domain AraC_binding PF02311.19 CDW53552.1 - 0.23 11.4 0.6 2.3 8.1 0.2 2.4 2 0 0 2 2 2 0 AraC-like ligand binding domain Y_phosphatase PF00102.27 CDW53553.1 - 1.3e-80 270.4 0.2 1.8e-80 269.9 0.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 CDW53553.1 - 0.00014 21.6 0.0 0.00031 20.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CDW53553.1 - 0.0012 18.9 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CDW53553.1 - 0.015 15.4 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate PHD PF00628.29 CDW53554.1 - 3.3e-09 36.5 6.0 5.6e-09 35.7 6.0 1.4 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.6 CDW53554.1 - 3.3e-09 36.9 0.0 1.2e-08 35.0 0.0 1.7 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 CDW53554.1 - 6.9e-08 32.9 0.3 1.2e-06 28.9 0.3 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase DUF2054 PF10218.9 CDW53554.1 - 0.0052 16.9 0.7 0.0085 16.2 0.7 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) zf-RING_9 PF13901.6 CDW53554.1 - 0.09 12.7 4.3 0.17 11.9 4.3 1.4 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-4CXXC_R1 PF10497.9 CDW53554.1 - 0.36 11.1 4.3 0.67 10.2 4.3 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 PHD_2 PF13831.6 CDW53554.1 - 1.1 8.8 6.5 0.072 12.7 1.3 1.7 2 0 0 2 2 2 0 PHD-finger PHD_4 PF16866.5 CDW53554.1 - 1.5 8.9 7.3 2.9 8.0 7.3 1.5 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 CDW53554.1 - 2.8 8.0 5.4 1 9.3 1.6 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.22 CDW53554.1 - 3.7 7.5 6.9 0.63 10.0 2.5 2.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 CDW53554.1 - 5.3 7.5 7.6 18 5.8 7.6 1.9 1 1 1 2 2 2 0 Ring finger domain WD40 PF00400.32 CDW53555.1 - 1.1e-08 35.5 4.4 0.079 13.9 0.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53555.1 - 0.0018 18.5 0.0 1.1 9.6 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW53555.1 - 0.068 12.5 0.1 0.41 9.9 0.1 2.0 1 1 1 2 2 2 0 WD40-like domain AARP2CN PF08142.12 CDW53555.1 - 0.077 13.1 0.1 0.36 10.9 0.1 2.1 1 1 0 1 1 1 0 AARP2CN (NUC121) domain IKI3 PF04762.12 CDW53555.1 - 0.095 10.7 0.0 0.14 10.2 0.0 1.2 1 0 0 1 1 1 0 IKI3 family Globin PF00042.22 CDW53556.1 - 6e-11 42.9 0.0 1.8e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 Globin Globin PF00042.22 CDW53557.1 - 2.5e-10 40.9 0.2 5.1e-10 39.9 0.2 1.5 1 0 0 1 1 1 1 Globin Globin PF00042.22 CDW53558.1 - 2.3e-12 47.4 0.0 3.3e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Globin DUF2931 PF11153.8 CDW53558.1 - 0.004 16.9 0.0 0.005 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2931) Lsm_C PF14894.6 CDW53558.1 - 0.0099 15.6 0.1 0.1 12.4 0.1 2.2 1 1 0 1 1 1 1 Lsm C-terminal zf-C2H2 PF00096.26 CDW53559.1 - 3.2e-14 52.5 43.9 1.1e-06 28.8 0.4 7.1 6 1 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW53559.1 - 2.9e-08 33.8 31.5 4e-07 30.2 0.9 5.7 6 0 0 6 6 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW53559.1 - 1.4e-07 31.7 43.2 0.0014 19.3 0.4 6.9 6 0 0 6 6 5 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CDW53559.1 - 1.7e-07 30.8 20.8 0.00026 20.6 3.6 4.7 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-BED PF02892.15 CDW53559.1 - 0.011 15.8 0.4 0.011 15.8 0.4 3.9 3 1 1 4 4 3 0 BED zinc finger zf-C2H2_7 PF15269.6 CDW53559.1 - 0.023 14.8 1.6 0.023 14.8 1.6 3.4 2 1 1 3 3 3 0 Zinc-finger zf-C2H2_6 PF13912.6 CDW53559.1 - 0.039 13.9 0.1 0.039 13.9 0.1 5.1 6 0 0 6 6 5 0 C2H2-type zinc finger Arc_trans_TRASH PF08394.10 CDW53559.1 - 0.14 12.5 6.0 0.32 11.4 0.1 3.4 3 0 0 3 3 3 0 Archaeal TRASH domain zf_C2H2_10 PF18414.1 CDW53559.1 - 0.14 11.7 0.0 0.14 11.7 0.0 2.9 3 0 0 3 3 3 0 C2H2 type zinc-finger zf-met PF12874.7 CDW53559.1 - 0.14 12.5 0.3 0.14 12.5 0.3 4.6 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW53559.1 - 0.16 12.3 0.1 0.16 12.3 0.1 4.5 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 CDW53559.1 - 1.1 9.7 7.2 0.27 11.6 1.7 2.8 2 1 1 3 3 3 0 zinc-finger-containing domain EMC1_C PF07774.13 CDW53560.1 - 3.6e-59 200.0 0.0 8e-59 198.9 0.0 1.6 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 CDW53560.1 - 1.1e-11 44.8 0.0 0.00045 19.9 0.0 3.6 3 1 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 CDW53560.1 - 1.8e-06 27.6 0.1 0.0027 17.6 0.0 3.8 4 0 0 4 4 4 2 PQQ enzyme repeat DUF3017 PF11222.8 CDW53560.1 - 0.1 12.8 0.1 0.72 10.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3017) PQQ_3 PF13570.6 CDW53560.1 - 0.16 12.5 0.1 94 3.7 0.0 4.3 6 0 0 6 6 6 0 PQQ-like domain Pkinase PF00069.25 CDW53561.1 - 9.3e-50 169.4 0.3 5.7e-49 166.9 0.0 2.0 1 1 1 2 2 2 1 Protein kinase domain C1_1 PF00130.22 CDW53561.1 - 1.6e-27 95.2 23.7 1.7e-13 50.2 9.3 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 CDW53561.1 - 1.1e-19 70.8 0.0 5.5e-18 65.2 0.0 2.2 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW53561.1 - 0.00017 21.0 0.0 0.00026 20.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDW53561.1 - 0.0034 16.8 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.16 CDW53561.1 - 0.0044 17.3 3.4 0.0044 17.3 3.4 4.0 4 0 0 4 4 4 2 C1 domain zf-RING_9 PF13901.6 CDW53561.1 - 0.057 13.4 19.9 0.025 14.5 5.2 2.7 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Pox_ser-thr_kin PF05445.11 CDW53561.1 - 0.072 12.1 1.0 0.085 11.8 0.1 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase FYVE_2 PF02318.16 CDW53561.1 - 0.41 10.9 14.5 0.21 11.8 3.2 2.8 2 0 0 2 2 2 0 FYVE-type zinc finger Ly-6_related PF06579.12 CDW53562.1 - 2.1e-25 89.4 4.3 2.7e-25 89.0 4.3 1.1 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein FNIP_M PF14637.6 CDW53563.1 - 3.2e-55 187.6 1.7 5.3e-55 186.9 1.7 1.3 1 0 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 CDW53563.1 - 2.9e-36 124.9 0.5 4.8e-36 124.2 0.5 1.3 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 CDW53563.1 - 2.2e-06 28.7 2.6 1.8e-05 25.7 0.3 4.2 3 2 1 4 4 4 2 Folliculin-interacting protein N-terminus SH3_2 PF07653.17 CDW53564.1 - 2.8e-22 78.1 0.0 6.5e-10 38.6 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CDW53564.1 - 2.1e-18 65.7 0.1 1.3e-13 50.3 0.1 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CDW53564.1 - 2.4e-18 65.7 0.1 2.2e-10 40.2 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 CDW53564.1 - 5e-17 61.8 0.0 9e-17 61.0 0.0 1.4 1 0 0 1 1 1 1 SH2 domain hSH3 PF14603.6 CDW53564.1 - 8.6e-05 22.9 0.0 0.0052 17.2 0.0 2.9 3 0 0 3 3 3 1 Helically-extended SH3 domain SH2_2 PF14633.6 CDW53564.1 - 0.18 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 SH2 domain HlyIII PF03006.20 CDW53565.1 - 3.3e-72 242.8 22.8 4.1e-72 242.5 22.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related CRCB PF02537.15 CDW53565.1 - 0.72 10.2 8.3 0.19 12.1 3.0 2.2 1 1 1 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) PDZ_6 PF17820.1 CDW53566.1 - 6.6e-10 38.7 0.1 1.4e-09 37.6 0.1 1.6 1 0 0 1 1 1 1 PDZ domain C1_1 PF00130.22 CDW53566.1 - 9.6e-10 38.2 6.4 1.9e-09 37.3 6.4 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PDZ_2 PF13180.6 CDW53566.1 - 9.2e-08 32.3 0.4 2.6e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 CDW53566.1 - 9.9e-06 25.8 0.0 2.3e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 CDW53566.1 - 0.0078 16.5 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PHD PF00628.29 CDW53566.1 - 0.056 13.3 3.2 0.14 12.1 3.2 1.6 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 CDW53566.1 - 0.064 13.4 1.9 0.16 12.1 1.9 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 CDW53566.1 - 0.082 12.8 1.0 0.22 11.5 1.0 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Paf1 PF03985.13 CDW53566.1 - 0.49 9.3 16.5 0.81 8.6 16.5 1.3 1 0 0 1 1 1 0 Paf1 zf-RING_2 PF13639.6 CDW53566.1 - 0.68 10.3 5.2 2 8.8 5.2 1.9 1 0 0 1 1 1 0 Ring finger domain Shisa PF13908.6 CDW53567.1 - 0.0033 17.7 16.2 0.15 12.3 16.2 2.1 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Comm PF15957.5 CDW53567.1 - 0.0038 17.6 0.0 0.0055 17.0 0.0 1.3 1 0 0 1 1 1 1 Commissureless MLANA PF14991.6 CDW53567.1 - 0.0078 16.5 2.3 0.017 15.4 1.7 1.7 1 1 0 1 1 1 1 Protein melan-A SARAF PF06682.12 CDW53567.1 - 0.064 12.9 2.9 0.43 10.2 2.9 2.0 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Mid2 PF04478.12 CDW53567.1 - 0.079 12.8 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF4834 PF16118.5 CDW53567.1 - 0.12 13.3 0.0 0.19 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 CDW53567.1 - 0.15 12.9 3.8 0.54 11.2 3.8 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CYYR1 PF10873.8 CDW53567.1 - 3.4 8.1 8.8 4.7 7.7 7.7 1.8 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 LIM PF00412.22 CDW53568.1 - 3.7e-49 164.8 59.3 5.1e-13 49.0 4.0 5.2 5 0 0 5 5 5 5 LIM domain Rap_GAP PF02145.15 CDW53569.1 - 4.3e-62 209.0 0.6 2.4e-61 206.5 0.6 2.2 1 1 0 1 1 1 1 Rap/ran-GAP Med21 PF11221.8 CDW53569.1 - 0.0024 18.1 0.4 0.0058 16.9 0.4 1.6 1 0 0 1 1 1 1 Subunit 21 of Mediator complex ATG16 PF08614.11 CDW53569.1 - 0.036 14.3 2.1 0.073 13.3 1.3 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) PDZ_6 PF17820.1 CDW53569.1 - 0.068 13.0 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 CDW53569.1 - 0.068 13.5 0.0 0.18 12.2 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Macoilin PF09726.9 CDW53569.1 - 0.074 11.6 10.6 0.21 10.1 10.6 1.6 1 1 0 1 1 1 0 Macoilin family Seryl_tRNA_N PF02403.22 CDW53569.1 - 0.093 13.0 0.7 0.2 11.9 0.7 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 CDW53569.1 - 0.1 13.0 3.7 0.24 11.8 3.7 1.6 1 0 0 1 1 1 0 Cell division protein ZapB ADIP PF11559.8 CDW53569.1 - 0.11 12.6 3.7 0.11 12.5 2.1 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 CDW53569.1 - 0.22 12.1 3.9 0.44 11.1 3.9 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 CDW53569.1 - 0.32 11.2 4.7 0.95 9.7 4.7 1.7 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Uso1_p115_C PF04871.13 CDW53569.1 - 0.33 11.3 3.4 0.83 10.0 3.4 1.6 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Cnn_1N PF07989.11 CDW53569.1 - 0.94 9.7 4.6 2.3 8.5 4.6 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 WAP PF00095.21 CDW53570.1 - 1.7e-16 60.3 19.8 8.8e-10 38.8 6.7 5.0 3 1 0 3 3 3 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' TIL PF01826.17 CDW53570.1 - 8.9e-09 35.5 14.6 8.9e-09 35.5 14.6 4.1 2 1 2 4 4 4 1 Trypsin Inhibitor like cysteine rich domain JAB PF01398.21 CDW53571.1 - 1.1e-16 60.8 0.0 1.9e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDW53571.1 - 6.1e-13 49.2 0.0 1e-12 48.4 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function MFS_1 PF07690.16 CDW53572.1 - 2.6e-15 56.2 21.4 7.9e-12 44.8 12.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily PDZ_6 PF17820.1 CDW53573.1 - 1.5e-05 24.8 0.0 8.2e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 CDW53573.1 - 9e-05 22.7 0.0 0.00018 21.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW53573.1 - 0.00096 19.5 0.0 0.002 18.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 CDW53574.1 - 2e-66 223.9 0.0 2.6e-66 223.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase WIF PF02019.18 CDW53574.1 - 3.7e-33 114.0 0.0 5.6e-33 113.4 0.0 1.3 1 0 0 1 1 1 1 WIF domain Pkinase PF00069.25 CDW53574.1 - 9.5e-26 90.7 0.0 1.4e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SGBP_B_XBD PF18329.1 CDW53574.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain AMP-binding PF00501.28 CDW53575.1 - 3.7e-79 266.3 0.0 4.8e-79 265.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW53575.1 - 1.5e-16 61.1 0.3 3.5e-16 59.9 0.3 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding_C_2 PF14535.6 CDW53575.1 - 0.18 12.1 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain SPC25 PF06703.11 CDW53576.1 - 8.3e-29 100.5 0.2 9.9e-29 100.2 0.2 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) TAF6_C PF07571.13 CDW53577.1 - 2e-23 82.5 0.1 8.1e-23 80.6 0.0 2.0 2 0 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 CDW53577.1 - 7.9e-10 38.8 0.5 1.8e-08 34.4 0.1 2.4 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 CDW53577.1 - 0.0016 18.5 0.0 0.0038 17.3 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 CDW53577.1 - 0.13 12.6 0.1 0.23 11.8 0.1 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 LIM PF00412.22 CDW53578.1 - 2.6e-17 62.8 18.7 1.7e-08 34.5 7.0 2.3 2 0 0 2 2 2 2 LIM domain DUF2175 PF09943.9 CDW53578.1 - 0.015 15.6 9.1 0.71 10.2 0.7 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-FLZ PF04570.14 CDW53578.1 - 1.8 8.1 17.2 0.26 10.8 0.6 4.0 3 1 1 4 4 4 0 zinc-finger of the FCS-type, C2-C2 RabGAP-TBC PF00566.18 CDW53579.1 - 2.4e-37 128.7 0.6 2.4e-37 128.7 0.6 1.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain dUTPase PF00692.19 CDW53580.1 - 2.1e-44 150.3 0.0 2.3e-44 150.2 0.0 1.0 1 0 0 1 1 1 1 dUTPase TTKRSYEDQ PF10212.9 CDW53581.1 - 4.9e-31 108.3 33.4 1.2e-19 70.7 10.2 3.2 2 1 1 3 3 3 2 Predicted coiled-coil domain-containing protein Filament PF00038.21 CDW53581.1 - 0.0033 17.1 25.8 0.13 11.8 9.1 3.3 2 1 0 3 3 3 2 Intermediate filament protein HMMR_N PF15905.5 CDW53581.1 - 0.013 15.0 25.8 0.25 10.8 7.9 2.7 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DASH_Dam1 PF08653.10 CDW53581.1 - 0.019 14.8 3.8 9.7 6.1 0.0 5.2 4 2 0 4 4 4 0 DASH complex subunit Dam1 DUF842 PF05811.13 CDW53581.1 - 0.037 13.7 0.1 0.037 13.7 0.1 3.3 3 1 0 3 3 3 0 Eukaryotic protein of unknown function (DUF842) CSN5_C PF18323.1 CDW53581.1 - 0.065 14.2 10.2 0.078 13.9 1.1 4.1 2 2 2 4 4 4 0 Cop9 signalosome subunit 5 C-terminal domain Jnk-SapK_ap_N PF09744.9 CDW53581.1 - 0.68 10.2 20.7 0.81 9.9 5.8 3.0 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF4618 PF15397.6 CDW53581.1 - 0.81 9.1 22.1 0.065 12.6 1.7 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4618) DUF4239 PF14023.6 CDW53581.1 - 4.4 7.0 5.7 6 6.5 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) DUF1635 PF07795.11 CDW53581.1 - 4.7 7.0 10.9 0.14 12.0 3.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Suppressor_APC PF11414.8 CDW53581.1 - 5 7.3 13.8 1.5 8.9 0.9 4.4 3 2 1 4 4 4 0 Adenomatous polyposis coli tumour suppressor protein Tropomyosin_1 PF12718.7 CDW53581.1 - 8.3 6.6 27.3 0.24 11.5 3.8 4.5 3 1 1 4 4 4 0 Tropomyosin like SOGA PF11365.8 CDW53581.1 - 9.7 7.4 18.2 17 6.6 0.8 4.1 3 1 0 3 3 3 0 Protein SOGA BRE PF06113.12 CDW53583.1 - 3.1e-24 85.4 0.2 3.7e-24 85.1 0.2 1.0 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) LEM PF03020.15 CDW53584.1 - 6.3e-09 35.3 0.0 1.2e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 LEM domain Ank_4 PF13637.6 CDW53584.1 - 0.00047 20.7 0.3 0.015 15.9 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW53584.1 - 0.00099 19.7 0.0 0.0029 18.2 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDW53584.1 - 0.0068 16.8 0.3 0.053 14.0 0.0 2.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 CDW53584.1 - 0.098 13.0 0.2 0.3 11.5 0.1 1.9 1 1 0 1 1 1 0 Ankyrin repeats (many copies) PI3K_P85_iSH2 PF16454.5 CDW53585.1 - 0.00027 20.6 7.1 0.00033 20.3 7.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Fmp27_WPPW PF10359.9 CDW53585.1 - 0.016 14.1 5.5 0.019 13.9 5.5 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Tropomyosin_1 PF12718.7 CDW53585.1 - 0.029 14.5 10.1 0.03 14.5 10.1 1.0 1 0 0 1 1 1 0 Tropomyosin like KASH_CCD PF14662.6 CDW53585.1 - 0.037 13.9 10.9 0.042 13.7 10.9 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Laminin_II PF06009.12 CDW53585.1 - 0.037 14.0 6.8 0.044 13.8 6.8 1.0 1 0 0 1 1 1 0 Laminin Domain II CENP-F_leu_zip PF10473.9 CDW53585.1 - 0.04 13.9 11.1 0.06 13.4 10.9 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spectrin PF00435.21 CDW53585.1 - 0.043 14.3 5.6 0.18 12.3 5.6 2.0 1 1 0 1 1 1 0 Spectrin repeat SHE3 PF17078.5 CDW53585.1 - 0.05 13.3 7.5 0.062 13.0 7.5 1.0 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Phage-MuB_C PF09077.11 CDW53585.1 - 0.053 13.4 0.0 0.091 12.7 0.0 1.4 1 1 0 1 1 1 0 Mu B transposition protein, C terminal TMPIT PF07851.13 CDW53585.1 - 0.058 12.6 6.4 0.063 12.5 6.4 1.0 1 0 0 1 1 1 0 TMPIT-like protein Noelin-1 PF12308.8 CDW53585.1 - 0.086 12.8 3.3 0.08 12.9 1.6 1.6 1 1 1 2 2 2 0 Neurogenesis glycoprotein TMF_TATA_bd PF12325.8 CDW53585.1 - 0.091 13.0 9.4 0.2 11.9 9.1 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Syntaxin-6_N PF09177.11 CDW53585.1 - 0.096 13.2 6.7 0.21 12.2 6.7 1.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal FPP PF05911.11 CDW53585.1 - 0.1 10.8 11.0 0.11 10.7 11.0 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil GAS PF13851.6 CDW53585.1 - 0.15 11.4 9.2 0.25 10.7 9.2 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 CDW53585.1 - 0.15 12.6 12.2 0.32 11.5 12.2 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region Atg14 PF10186.9 CDW53585.1 - 0.16 11.0 7.7 0.21 10.7 7.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 CDW53585.1 - 0.16 11.7 6.8 0.063 13.1 3.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF16 PF01519.16 CDW53585.1 - 0.18 12.3 3.9 0.32 11.5 3.8 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 HAUS5 PF14817.6 CDW53585.1 - 0.19 10.5 5.8 0.22 10.2 5.8 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 DUF948 PF06103.11 CDW53585.1 - 0.2 12.0 1.5 1.3 9.4 0.5 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DivIVA PF05103.13 CDW53585.1 - 0.21 11.7 7.9 0.25 11.5 7.9 1.1 1 0 0 1 1 1 0 DivIVA protein DUF4407 PF14362.6 CDW53585.1 - 0.28 10.5 2.7 0.3 10.4 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4094 PF13334.6 CDW53585.1 - 0.28 11.6 2.6 0.39 11.1 1.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) CENP-Q PF13094.6 CDW53585.1 - 0.29 11.3 7.9 0.55 10.4 7.9 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit YlqD PF11068.8 CDW53585.1 - 0.3 11.5 8.7 46 4.4 8.7 2.0 1 1 0 1 1 1 0 YlqD protein Spc7 PF08317.11 CDW53585.1 - 0.34 9.7 9.2 0.52 9.1 9.2 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein TSNAXIP1_N PF15739.5 CDW53585.1 - 0.36 11.2 8.2 0.26 11.7 2.8 2.0 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus Fez1 PF06818.15 CDW53585.1 - 0.36 11.3 6.9 0.54 10.7 6.9 1.2 1 0 0 1 1 1 0 Fez1 ZapD PF07072.11 CDW53585.1 - 0.36 10.6 4.6 0.42 10.3 4.6 1.2 1 0 0 1 1 1 0 Cell division protein DUF1043 PF06295.12 CDW53585.1 - 0.4 10.7 6.2 0.75 9.8 6.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) SlyX PF04102.12 CDW53585.1 - 0.4 11.3 6.4 0.86 10.3 4.1 2.0 1 1 1 2 2 2 0 SlyX CENP-H PF05837.12 CDW53585.1 - 0.46 10.9 6.9 0.19 12.2 3.8 1.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ADIP PF11559.8 CDW53585.1 - 0.47 10.5 8.7 0.89 9.6 8.4 1.7 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding PRKG1_interact PF15898.5 CDW53585.1 - 0.5 11.3 10.3 1.7 9.6 4.3 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF5082 PF16888.5 CDW53585.1 - 0.59 10.4 8.3 19 5.5 1.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) OmpH PF03938.14 CDW53585.1 - 0.64 10.3 7.2 0.82 10.0 7.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Sec2p PF06428.11 CDW53585.1 - 0.68 9.9 11.2 1.4 8.9 4.9 2.4 1 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p Prefoldin PF02996.17 CDW53585.1 - 0.74 9.7 8.0 1.8 8.5 2.0 2.4 1 1 2 3 3 3 0 Prefoldin subunit GrpE PF01025.19 CDW53585.1 - 0.87 9.2 7.8 1.4 8.6 7.8 1.4 1 1 0 1 1 1 0 GrpE UPF0242 PF06785.11 CDW53585.1 - 0.97 9.5 10.7 1.7 8.7 10.7 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 CDW53585.1 - 1.3 8.2 8.6 1.6 8.0 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 CDW53585.1 - 1.3 9.2 6.7 3.6 7.8 4.1 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Spc24 PF08286.11 CDW53585.1 - 1.5 9.1 9.5 1.4 9.2 3.5 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Lipoprotein_20 PF13942.6 CDW53585.1 - 1.5 8.7 7.7 2 8.3 0.3 2.0 1 1 1 2 2 2 0 YfhG lipoprotein V_ATPase_I PF01496.19 CDW53585.1 - 2 6.2 5.8 2.6 5.9 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Csm1_N PF18504.1 CDW53585.1 - 5.2 7.5 10.2 8.3 6.8 2.7 2.8 1 1 2 3 3 3 0 Csm1 N-terminal domain YabA PF06156.13 CDW53585.1 - 7.3 7.3 7.4 49 4.6 7.4 1.9 1 1 0 1 1 1 0 Initiation control protein YabA TMF_DNA_bd PF12329.8 CDW53585.1 - 8.7 6.4 15.0 15 5.7 8.6 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SOGA PF11365.8 CDW53586.1 - 9.7e-11 42.7 18.5 2e-10 41.7 4.7 15.7 7 4 10 17 17 17 3 Protein SOGA FAM184 PF15665.5 CDW53586.1 - 0.0029 17.4 6.8 0.0029 17.4 6.8 11.1 4 4 4 10 10 10 1 Family with sequence similarity 184, A and B HALZ PF02183.18 CDW53586.1 - 0.0034 17.6 1.0 0.0034 17.6 1.0 13.1 17 0 0 17 17 17 1 Homeobox associated leucine zipper GIT_CC PF16559.5 CDW53586.1 - 0.016 15.1 0.3 0.016 15.1 0.3 10.0 12 1 1 13 13 13 0 GIT coiled-coil Rho guanine nucleotide exchange factor Ribonucleas_3_2 PF11469.8 CDW53586.1 - 2.8 8.4 4.9 17 5.8 0.3 3.2 2 0 0 2 2 2 0 Ribonuclease III Histone PF00125.24 CDW53588.1 - 1.2e-10 41.9 0.1 1.7e-10 41.4 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 zf-C2H2 PF00096.26 CDW53589.1 - 3.1e-23 80.9 43.6 2.1e-05 24.7 2.3 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW53589.1 - 3.7e-20 71.4 36.3 9.7e-06 25.8 0.3 6.4 6 1 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW53589.1 - 1.3e-17 62.9 38.3 0.0026 18.5 1.6 5.3 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW53589.1 - 1.3e-05 25.0 35.2 0.0055 16.7 1.8 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW53589.1 - 1.3e-05 25.3 21.1 0.39 11.1 0.8 5.0 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding XPA_N PF01286.18 CDW53589.1 - 0.00032 20.7 11.7 2.4 8.3 0.3 4.5 4 0 0 4 4 4 2 XPA protein N-terminal zf-met PF12874.7 CDW53589.1 - 0.00043 20.6 26.4 0.4 11.1 0.1 5.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type GAGA PF09237.11 CDW53589.1 - 0.0014 18.4 20.7 0.22 11.3 0.1 4.8 1 1 4 5 5 5 3 GAGA factor zf-C2HC_2 PF13913.6 CDW53589.1 - 0.0018 18.2 23.6 0.0096 15.8 0.7 4.8 4 0 0 4 4 4 1 zinc-finger of a C2HC-type C1_4 PF07975.12 CDW53589.1 - 0.0094 16.2 22.6 0.93 9.8 0.3 3.6 2 1 2 4 4 4 2 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 CDW53589.1 - 0.01 15.9 2.5 0.01 15.9 2.5 3.6 3 1 1 4 4 3 0 Zinc ribbon domain zf_UBZ PF18439.1 CDW53589.1 - 0.089 12.4 12.6 1.7 8.3 0.2 4.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger LIM PF00412.22 CDW53589.1 - 0.093 13.0 14.0 6.1 7.2 0.3 3.7 2 1 2 4 4 4 0 LIM domain Thioredoxin_16 PF18569.1 CDW53589.1 - 0.11 12.6 0.5 5.7 7.1 0.3 2.4 2 1 0 2 2 2 0 Thioredoxin-like domain Desulfoferrod_N PF06397.12 CDW53589.1 - 0.16 11.6 1.2 8.4 6.1 0.2 2.6 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-AN1 PF01428.16 CDW53589.1 - 0.2 11.8 30.3 0.3 11.3 3.6 5.3 4 1 1 5 5 5 0 AN1-like Zinc finger DUF3268 PF11672.8 CDW53589.1 - 0.3 11.4 7.8 1.2 9.5 0.3 2.7 2 1 1 3 3 3 0 zinc-finger-containing domain ADK_lid PF05191.14 CDW53589.1 - 0.36 10.8 17.5 0.86 9.6 1.3 3.6 3 1 0 3 3 3 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.5 CDW53589.1 - 4 8.3 15.9 2 9.2 2.2 2.8 1 1 0 2 2 2 0 zinc-ribbon family zf-BED PF02892.15 CDW53589.1 - 5.5 7.1 24.8 0.85 9.7 3.3 4.5 1 1 2 4 4 4 0 BED zinc finger zf-C2HE PF16278.5 CDW53589.1 - 9.1 6.8 28.8 0.086 13.3 3.5 4.8 2 1 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger GTP_EFTU PF00009.27 CDW53591.1 - 1.2e-62 211.0 0.0 1.7e-62 210.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDW53591.1 - 1.1e-34 118.8 0.0 3.7e-34 117.1 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 CDW53591.1 - 1.4e-23 82.7 0.0 4.4e-23 81.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CDW53591.1 - 6.8e-14 51.7 0.0 1.7e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CDW53591.1 - 2.1e-10 40.8 0.0 5.1e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW53591.1 - 0.001 19.1 0.0 0.0019 18.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Y_phosphatase PF00102.27 CDW53592.1 - 7.3e-59 199.2 0.0 7.8e-36 123.8 0.1 2.1 1 1 1 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 CDW53592.1 - 0.00017 21.4 0.0 0.00036 20.3 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain WH2 PF02205.20 CDW53593.1 - 3.8e-13 48.8 0.6 3.2e-05 23.6 0.1 2.8 2 0 0 2 2 2 2 WH2 motif Pex14_N PF04695.13 CDW53594.1 - 0.15 12.7 0.1 0.28 11.9 0.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Sec61_beta PF03911.16 CDW53594.1 - 0.32 11.1 2.8 0.66 10.1 2.8 1.5 1 0 0 1 1 1 0 Sec61beta family Trep_dent_lipo PF09710.10 CDW53595.1 - 0.014 14.4 0.0 0.017 14.1 0.0 1.1 1 0 0 1 1 1 0 Treponema clustered lipoprotein (Trep_dent_lipo) GATase PF00117.28 CDW53596.1 - 1.4e-31 109.8 0.0 3.5e-31 108.4 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 CDW53596.1 - 2.5e-12 46.7 0.0 4.5e-07 29.8 0.1 3.0 2 1 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.13 CDW53596.1 - 1.2e-11 44.8 0.1 2.8e-11 43.6 0.1 1.6 1 1 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 CDW53596.1 - 1.8e-09 37.1 0.0 1e-05 24.8 0.1 2.2 2 0 0 2 2 2 2 NAD synthase tRNA_Me_trans PF03054.16 CDW53596.1 - 0.00057 18.8 0.0 0.0018 17.1 0.0 1.7 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 CDW53596.1 - 0.0036 16.8 0.0 0.016 14.7 0.0 1.9 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 CDW53596.1 - 0.022 14.8 0.0 0.056 13.5 0.0 1.7 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Asn_synthase PF00733.21 CDW53596.1 - 0.037 13.7 0.0 0.1 12.2 0.0 1.6 2 0 0 2 2 2 0 Asparagine synthase Arginosuc_synth PF00764.19 CDW53596.1 - 0.05 12.9 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase Init_tRNA_PT PF04179.12 CDW53596.1 - 0.11 12.8 0.1 0.29 11.5 0.1 1.6 1 0 0 1 1 1 0 Rit1 DUSP-like domain L27_N PF09060.10 CDW53597.1 - 0.0026 17.8 0.5 0.0062 16.6 0.5 1.7 1 0 0 1 1 1 1 L27_N Suv3_N PF18114.1 CDW53597.1 - 0.084 13.0 0.4 0.81 9.8 0.2 2.3 1 1 1 2 2 2 0 Suv3 helical N-terminal domain PAS_9 PF13426.7 CDW53598.1 - 0.00034 20.8 0.0 0.021 15.1 0.0 3.0 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 CDW53598.1 - 0.0059 16.6 0.0 0.024 14.6 0.0 2.0 2 0 0 2 2 2 1 PAS fold ubiquitin PF00240.23 CDW53599.1 - 1.5e-32 111.1 0.1 2.1e-32 110.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 CDW53599.1 - 5.3e-31 106.3 8.2 8.4e-31 105.6 8.2 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CDW53599.1 - 4e-16 58.6 0.1 5.6e-16 58.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDW53599.1 - 0.00027 21.3 0.1 0.0014 19.0 0.0 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 CDW53599.1 - 0.02 15.2 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain TBK1_ULD PF18396.1 CDW53599.1 - 0.04 13.9 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDW53599.1 - 0.044 13.9 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DnaJ PF00226.31 CDW53600.1 - 1.8e-06 28.0 0.0 2.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 CDW53600.1 - 0.0079 16.2 0.0 0.0087 16.1 0.0 1.0 1 0 0 1 1 1 1 Pam16 Cofilin_ADF PF00241.20 CDW53601.1 - 9.2e-56 186.9 1.2 4.4e-29 100.7 0.1 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein adh_short PF00106.25 CDW53602.1 - 2e-36 125.3 0.0 2.4e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW53602.1 - 3.9e-32 111.7 0.0 5.2e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW53602.1 - 2e-09 37.6 0.7 7.5e-09 35.7 0.7 1.8 1 1 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.21 CDW53602.1 - 0.043 13.9 0.0 0.077 13.1 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Ribosomal_L35p PF01632.19 CDW53603.1 - 0.014 15.9 0.0 0.031 14.8 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L35 WD40 PF00400.32 CDW53604.1 - 1.5e-26 92.1 13.9 1.1e-07 32.4 0.2 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53604.1 - 6.6e-08 32.7 0.0 4.5e-05 23.7 0.0 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW53604.1 - 0.00016 21.1 0.0 0.14 11.5 0.0 2.5 3 0 0 3 3 3 2 WD40-like domain DUF1513 PF07433.11 CDW53604.1 - 0.02 14.0 0.0 0.056 12.5 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1513) CSS-motif PF12792.7 CDW53604.1 - 0.034 13.6 0.0 1.7 8.1 0.0 2.2 2 0 0 2 2 2 0 CSS motif domain associated with EAL TMEM65 PF10507.9 CDW53605.1 - 1.9e-41 140.4 4.0 3.5e-41 139.6 4.0 1.4 1 0 0 1 1 1 1 Transmembrane protein 65 Romo1 PF10247.9 CDW53605.1 - 0.0083 16.5 1.6 0.015 15.6 0.0 2.1 2 0 0 2 2 2 1 Reactive mitochondrial oxygen species modulator 1 DUF2465 PF10239.9 CDW53606.1 - 4.9e-85 285.6 7.6 7.5e-58 196.3 1.4 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF2465) U3_assoc_6 PF08640.11 CDW53607.1 - 9.8e-10 38.4 3.9 6.1e-09 35.8 1.0 3.1 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.10 CDW53607.1 - 0.00012 21.4 0.1 0.0026 16.9 0.1 2.6 2 1 0 2 2 2 1 NRDE-2, necessary for RNA interference Glyco_hydro_31 PF01055.26 CDW53609.1 - 7.3e-140 467.0 4.1 9.3e-140 466.7 4.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CDW53609.1 - 5e-17 62.2 0.2 1.2e-16 60.9 0.0 1.7 2 0 0 2 2 2 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CDW53609.1 - 1.3e-06 28.6 0.2 4.1e-06 27.0 0.2 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like Trefoil PF00088.18 CDW53609.1 - 3.2e-06 26.9 4.2 3.2e-06 26.9 4.2 1.8 2 0 0 2 2 2 1 Trefoil (P-type) domain TPR_14 PF13428.6 CDW53610.1 - 1.3e-18 66.1 17.3 0.15 13.0 0.1 12.1 9 4 6 15 15 12 5 Tetratricopeptide repeat Suf PF05843.14 CDW53610.1 - 2e-11 44.4 6.6 0.00012 22.2 0.0 5.9 4 1 1 5 5 5 3 Suppressor of forked protein (Suf) TPR_15 PF13429.6 CDW53610.1 - 3.3e-08 33.1 7.0 0.44 9.7 0.0 5.6 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDW53610.1 - 3.8e-08 32.9 21.0 0.065 13.5 0.2 7.9 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDW53610.1 - 1.2e-07 31.3 20.7 0.009 16.1 0.8 8.1 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDW53610.1 - 1.9e-06 28.3 7.5 2 9.0 0.0 6.7 7 1 0 7 7 6 2 Tetratricopeptide repeat NRDE-2 PF08424.10 CDW53610.1 - 2.8e-06 26.7 22.3 0.026 13.6 0.0 6.4 4 2 1 6 6 6 2 NRDE-2, necessary for RNA interference TPR_7 PF13176.6 CDW53610.1 - 6e-06 25.9 6.6 0.0038 17.2 0.1 5.4 5 0 0 5 5 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDW53610.1 - 4.1e-05 23.5 19.6 0.079 12.9 0.2 6.6 6 3 0 6 6 6 2 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 CDW53610.1 - 0.0002 21.5 10.8 0.054 13.8 0.1 6.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW53610.1 - 0.00044 20.4 10.7 13 6.4 0.0 7.9 7 2 1 8 8 7 0 Tetratricopeptide repeat PPR PF01535.20 CDW53610.1 - 0.007 16.5 0.0 15 6.1 0.0 3.8 2 0 0 2 2 2 0 PPR repeat TPR_4 PF07721.14 CDW53610.1 - 0.013 16.0 0.8 3.6 8.5 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW53610.1 - 0.098 12.9 10.4 9 6.6 0.0 6.0 7 1 1 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 CDW53610.1 - 0.3 10.8 3.3 2.2 8.0 0.0 2.9 3 1 0 3 3 2 0 26S proteasome subunit RPN7 SNAP PF14938.6 CDW53610.1 - 0.55 9.6 7.1 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 CDW53610.1 - 4.6 8.1 16.2 24 5.8 0.1 7.6 8 0 0 8 8 7 0 Tetratricopeptide repeat dsDNA_bind PF01984.20 CDW53611.1 - 3.1e-20 72.5 0.0 3.5e-20 72.3 0.0 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Cgr1 PF03879.14 CDW53612.1 - 7.4e-11 42.4 13.5 9.1e-11 42.1 13.5 1.1 1 0 0 1 1 1 1 Cgr1 family DUF2058 PF09831.9 CDW53612.1 - 0.075 13.2 6.4 0.096 12.8 6.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) CLZ PF16526.5 CDW53614.1 - 0.0016 18.7 1.9 0.058 13.8 1.0 3.2 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels EF-hand_like PF09279.11 CDW53614.1 - 0.55 10.8 2.3 3.4 8.2 0.3 2.5 2 0 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like TMPIT PF07851.13 CDW53614.1 - 5 6.3 9.7 0.039 13.2 0.6 2.0 3 0 0 3 3 3 0 TMPIT-like protein Gpr1_Fun34_YaaH PF01184.19 CDW53615.1 - 6.4e-32 110.8 11.3 8.1e-32 110.5 11.3 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF4203 PF13886.6 CDW53615.1 - 2.4 7.8 16.9 0.78 9.4 4.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) Kazal_1 PF00050.21 CDW53616.1 - 5.8e-19 67.8 34.4 1.2e-07 31.6 8.1 4.2 2 1 2 4 4 4 4 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 CDW53616.1 - 3.2e-18 65.6 36.0 3.5e-06 27.0 3.2 4.3 2 1 2 4 4 4 4 Kazal-type serine protease inhibitor domain Peptidase_C71 PF12386.8 CDW53616.1 - 0.31 10.7 6.2 0.5 10.0 6.2 1.3 1 0 0 1 1 1 0 Pseudomurein endo-isopeptidase Pei Peptidase_M2 PF01401.18 CDW53617.1 - 0 1282.6 33.7 1.7e-161 538.7 7.2 3.0 3 0 0 3 3 3 3 Angiotensin-converting enzyme Acid_PPase PF12689.7 CDW53617.1 - 0.17 11.7 1.4 9.5 6.0 0.1 2.7 2 0 0 2 2 2 0 Acid Phosphatase Corona_M PF01635.18 CDW53618.1 - 0.14 11.4 4.2 0.18 11.1 4.2 1.1 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein WAP PF00095.21 CDW53619.1 - 2.3e-17 63.1 29.0 5.1e-10 39.6 9.3 2.2 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Somatomedin_B PF01033.17 CDW53619.1 - 0.025 15.0 16.8 0.1 13.0 5.8 2.4 2 0 0 2 2 2 0 Somatomedin B domain EB PF01683.18 CDW53620.1 - 0.00014 22.1 10.1 0.0097 16.2 3.6 2.6 1 1 2 3 3 3 3 EB module Dickkopf_N PF04706.12 CDW53620.1 - 0.0015 19.0 16.9 0.0095 16.4 1.7 2.7 2 1 0 2 2 2 2 Dickkopf N-terminal cysteine-rich region Squash PF00299.18 CDW53620.1 - 2.8 8.0 17.8 0.16 12.0 3.7 2.8 3 0 0 3 3 3 0 Squash family serine protease inhibitor Toxin_12 PF07740.12 CDW53620.1 - 3.4 8.4 10.9 2.5 8.9 1.0 2.8 3 0 0 3 3 3 0 Ion channel inhibitory toxin Diphthamide_syn PF01866.17 CDW53621.1 - 3.4e-59 200.8 0.2 2.7e-56 191.2 0.2 2.0 1 1 0 1 1 1 1 Putative diphthamide synthesis protein DEAD PF00270.29 CDW53622.1 - 4e-20 72.3 0.1 9.9e-20 71.0 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RQC PF09382.10 CDW53622.1 - 8e-15 54.6 0.0 1.9e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 CDW53622.1 - 2.6e-14 53.5 0.0 1e-13 51.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 CDW53622.1 - 2e-12 47.6 1.2 3.8e-12 46.7 0.2 2.1 2 0 0 2 2 2 1 RecQ zinc-binding HRDC PF00570.23 CDW53622.1 - 1.1e-10 41.3 0.0 2.2e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 CDW53622.1 - 4.8e-08 33.2 0.0 9.2e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Sep15_SelM PF08806.11 CDW53623.1 - 4e-14 52.5 0.0 6.5e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Sep15/SelM redox domain ParA PF10609.9 CDW53624.1 - 1.1e-78 264.1 0.2 1.3e-78 263.8 0.2 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CDW53624.1 - 4.8e-10 39.6 0.0 6.8e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDW53624.1 - 1.5e-06 28.3 0.9 1.5e-05 24.9 0.9 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 CDW53624.1 - 5.4e-06 25.9 0.0 7.2e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 CDW53624.1 - 0.0041 16.4 0.2 0.055 12.6 0.1 2.5 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_26 PF13500.6 CDW53624.1 - 0.011 15.5 0.1 2.1 8.1 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDW53624.1 - 0.025 14.2 0.1 0.09 12.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain FTHFS PF01268.19 CDW53624.1 - 0.065 11.4 0.1 0.1 10.8 0.1 1.2 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase CBP_BcsQ PF06564.12 CDW53624.1 - 0.11 12.0 0.1 0.53 9.7 0.1 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 CDW53624.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop VirC1 PF07015.11 CDW53624.1 - 0.16 11.3 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein GYF PF02213.16 CDW53625.1 - 0.027 14.1 0.1 0.051 13.2 0.1 1.4 1 0 0 1 1 1 0 GYF domain Peptidase_C1 PF00112.23 CDW53626.1 - 1.6e-66 224.6 1.1 2.7e-66 223.8 1.1 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 CDW53626.1 - 4.6e-14 52.6 3.5 1.1e-10 41.7 0.3 2.9 2 0 0 2 2 2 2 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 CDW53626.1 - 2.7e-07 29.7 0.9 0.00039 19.3 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Cystatin PF00031.21 CDW53626.1 - 4.1e-07 30.2 0.1 1.2e-06 28.7 0.1 1.8 1 0 0 1 1 1 1 Cystatin domain Cathelicidins PF00666.17 CDW53626.1 - 3.3e-05 24.1 0.1 0.0001 22.6 0.1 1.8 1 0 0 1 1 1 1 Cathelicidin Ribosomal_S8e PF01201.22 CDW53627.1 - 8.6e-54 181.4 0.8 1e-53 181.2 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e Aminotran_1_2 PF00155.21 CDW53628.1 - 1.9e-46 158.9 0.0 3.3e-46 158.1 0.0 1.3 2 0 0 2 2 2 1 Aminotransferase class I and II zf-Tim10_DDP PF02953.15 CDW53628.1 - 5.4e-16 58.0 6.0 5.4e-16 58.0 6.0 1.9 2 0 0 2 2 2 1 Tim10/DDP family zinc finger Cys_Met_Meta_PP PF01053.20 CDW53628.1 - 2.3e-05 23.1 0.0 4e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CDW53628.1 - 0.00066 19.1 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CDW53628.1 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CDW53628.1 - 0.012 14.6 0.0 0.026 13.5 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-V DUF842 PF05811.13 CDW53628.1 - 0.72 9.6 6.9 0.59 9.8 1.8 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) SRP14 PF02290.15 CDW53629.1 - 2.1e-26 92.1 0.3 2.6e-26 91.8 0.3 1.1 1 0 0 1 1 1 1 Signal recognition particle 14kD protein dsrm PF00035.26 CDW53630.1 - 7.8e-13 48.9 0.1 2e-05 25.2 0.1 3.0 2 0 0 2 2 2 2 Double-stranded RNA binding motif OB_NTP_bind PF07717.16 CDW53630.1 - 1.5e-11 44.5 0.2 3.3e-11 43.4 0.2 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CDW53630.1 - 3.4e-11 43.4 0.0 7.3e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDW53630.1 - 2.5e-09 37.5 0.0 1.6e-08 34.8 0.0 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW53630.1 - 4.7e-07 29.8 0.0 1.5e-06 28.1 0.0 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase Dicer_dimer PF03368.14 CDW53630.1 - 0.00027 21.0 0.4 0.31 11.2 0.2 2.7 2 0 0 2 2 2 2 Dicer dimerisation domain ATPase PF06745.13 CDW53630.1 - 0.011 15.1 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_19 PF13245.6 CDW53630.1 - 0.021 15.1 0.0 0.061 13.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDW53630.1 - 0.023 15.0 0.5 0.15 12.3 0.5 2.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDW53630.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 CDW53630.1 - 0.08 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein FERM_C PF09380.10 CDW53631.1 - 4.5e-13 49.4 0.0 1.3e-12 47.9 0.0 1.7 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FERM_M PF00373.18 CDW53631.1 - 1.2e-12 48.3 0.0 3.8e-12 46.7 0.0 1.9 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 CDW53631.1 - 3.1e-09 36.6 0.0 5.5e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 FERM N-terminal domain Arm PF00514.23 CDW53633.1 - 0.0077 16.2 4.4 1.1 9.3 0.1 3.2 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Ephrin_rec_like PF07699.13 CDW53634.1 - 2.6e-08 33.5 69.1 0.0031 17.3 4.0 8.8 5 3 4 9 9 9 6 Putative ephrin-receptor like NCD3G PF07562.14 CDW53634.1 - 0.0071 16.3 13.4 0.014 15.4 1.2 8.6 8 1 0 8 8 8 4 Nine Cysteines Domain of family 3 GPCR AgrB PF04647.15 CDW53634.1 - 0.14 11.4 0.2 0.34 10.2 0.2 1.5 1 0 0 1 1 1 0 Accessory gene regulator B Ion_trans PF00520.31 CDW53635.1 - 8.6e-40 136.5 14.9 1.2e-39 136.0 14.9 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 CDW53635.1 - 2.5e-27 95.1 1.3 3.5e-27 94.6 0.3 1.7 2 0 0 2 2 2 1 BTB/POZ domain Shal-type PF11601.8 CDW53635.1 - 4e-13 48.6 5.6 7.3e-13 47.8 5.6 1.4 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.16 CDW53635.1 - 4.8e-12 45.7 8.5 4.8e-12 45.7 8.5 2.4 2 0 0 2 2 2 1 Ion channel BTB_3 PF16017.5 CDW53635.1 - 0.00096 19.2 0.0 0.0047 17.0 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain G0-G1_switch_2 PF15103.6 CDW53635.1 - 0.013 15.9 0.1 6.6 7.2 0.0 2.7 2 1 0 2 2 2 0 G0/G1 switch protein 2 COX2-transmemb PF09125.10 CDW53635.1 - 0.11 12.3 3.2 0.095 12.5 1.0 2.0 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane PKD_channel PF08016.12 CDW53635.1 - 0.65 8.6 9.9 1.6 7.3 9.9 1.5 1 1 0 1 1 1 0 Polycystin cation channel Cytochrom_B_C PF00032.17 CDW53635.1 - 1.3 9.3 7.4 2 8.8 2.5 2.4 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD ThiF PF00899.21 CDW53636.1 - 2.6e-56 190.7 0.0 4.2e-56 190.0 0.0 1.3 1 1 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 CDW53636.1 - 0.0044 17.1 0.0 0.0085 16.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF5122 PF17164.4 CDW53636.1 - 0.015 15.6 0.0 0.015 15.6 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller Pyr_redox PF00070.27 CDW53636.1 - 0.091 13.3 0.0 0.42 11.2 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 CDW53636.1 - 0.17 12.2 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Zona_pellucida PF00100.23 CDW53637.1 - 1.8e-13 50.9 0.9 2.6e-13 50.4 0.9 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain CD99L2 PF12301.8 CDW53638.1 - 0.035 14.4 0.0 0.049 13.9 0.0 1.3 1 0 0 1 1 1 0 CD99 antigen like protein 2 DSX_dimer PF08828.10 CDW53638.1 - 0.33 10.6 1.4 7.4 6.3 0.2 2.2 2 0 0 2 2 2 0 Doublesex dimerisation domain NUDIX PF00293.28 CDW53639.1 - 1.9e-11 44.1 0.0 2.7e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Acyl-CoA_dh_1 PF00441.24 CDW53640.1 - 1.2e-38 132.7 0.3 1.7e-38 132.2 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDW53640.1 - 3.1e-27 95.5 0.0 6.4e-27 94.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CDW53640.1 - 1.1e-25 89.6 0.0 2.3e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CDW53640.1 - 9.6e-11 42.1 0.1 1.4e-10 41.6 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cystatin PF00031.21 CDW53641.1 - 5.3e-09 36.2 0.0 6.3e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Cystatin domain Pro_isomerase PF00160.21 CDW53642.1 - 2.1e-49 167.8 0.2 2.4e-49 167.7 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4404 PF14357.6 CDW53643.1 - 0.075 13.7 0.4 0.24 12.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF1018 PF06252.12 CDW53643.1 - 0.11 13.5 0.1 0.27 12.2 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Stealth_CR3 PF17102.5 CDW53643.1 - 0.13 12.1 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Stealth protein CR3, conserved region 3 Astacin PF01400.24 CDW53644.1 - 4.1e-65 219.0 0.0 5.4e-65 218.6 0.0 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 CDW53644.1 - 5.6e-17 62.0 20.8 3.5e-08 33.8 4.9 2.8 2 0 0 2 2 2 2 ShK domain-like F-box-like PF12937.7 CDW53645.1 - 5.4e-10 39.0 2.7 1.8e-09 37.3 2.7 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDW53645.1 - 1e-07 31.6 0.9 1e-07 31.6 0.9 2.4 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 CDW53645.1 - 0.0063 16.5 14.8 0.76 10.0 0.2 7.4 8 0 0 8 8 8 2 Leucine Rich repeat Col_cuticle_N PF01484.17 CDW53646.1 - 8.8e-13 48.1 0.7 1.2e-12 47.7 0.7 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Collagen PF01391.18 CDW53646.1 - 6.7e-12 45.0 67.2 3.2e-07 30.0 29.2 7.9 5 2 2 7 7 7 3 Collagen triple helix repeat (20 copies) zf-C2H2 PF00096.26 CDW53647.1 - 1.5e-12 47.2 17.8 2.5e-05 24.5 0.2 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW53647.1 - 3.1e-11 43.1 15.7 0.002 18.8 1.6 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW53647.1 - 4.9e-11 42.5 12.0 6e-05 23.3 0.2 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW53647.1 - 4.1e-05 23.7 5.1 0.26 11.7 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CDW53647.1 - 0.012 15.9 7.8 0.55 10.6 0.1 3.2 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 CDW53647.1 - 0.035 14.1 1.4 0.035 14.1 1.4 3.8 3 1 1 4 4 4 0 BED zinc finger zf-C2H2_11 PF16622.5 CDW53647.1 - 0.051 13.4 13.8 1.8 8.4 1.7 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 CDW53647.1 - 0.16 12.4 5.8 0.18 12.2 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type PyrI_C PF02748.15 CDW53647.1 - 0.81 9.6 11.0 7.5 6.6 2.0 3.4 3 1 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 CDW53647.1 - 2.9 8.0 15.7 0.43 10.6 2.2 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger DUF678 PF05077.12 CDW53647.1 - 3.2 7.9 9.1 0.29 11.3 2.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF678) OrsD PF12013.8 CDW53647.1 - 5.4 7.5 11.6 0.92 10.0 0.4 3.5 1 1 2 4 4 4 0 Orsellinic acid/F9775 biosynthesis cluster protein D Hist_deacetyl PF00850.19 CDW53649.1 - 2.4e-79 267.0 0.0 3.1e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain ThiF PF00899.21 CDW53649.1 - 0.14 11.5 0.3 1.5 8.1 0.1 2.0 1 1 1 2 2 2 0 ThiF family EF-hand_1 PF00036.32 CDW53650.1 - 2.5e-07 29.8 4.6 0.0068 15.9 0.1 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 CDW53650.1 - 1.1e-06 28.9 5.0 5.2e-06 26.8 1.0 3.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDW53650.1 - 5.2e-06 26.0 1.1 0.015 15.2 0.1 3.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 CDW53650.1 - 1.3e-05 25.0 5.9 0.038 13.8 1.5 3.8 3 1 1 4 4 4 2 EF-hand domain pair LHH PF14411.6 CDW53650.1 - 0.042 14.0 0.4 0.73 10.1 0.1 2.7 3 0 0 3 3 3 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH EF-hand_5 PF13202.6 CDW53650.1 - 0.18 11.3 1.4 0.36 10.4 0.1 2.2 2 0 0 2 2 2 0 EF hand Peptidase_C12 PF01088.21 CDW53651.1 - 1.7e-48 165.2 0.0 3.5e-48 164.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 G-patch PF01585.23 CDW53651.1 - 5.5e-10 39.0 0.3 1.2e-09 37.9 0.3 1.5 1 0 0 1 1 1 1 G-patch domain UCH_C PF18031.1 CDW53651.1 - 5.5e-07 29.4 0.5 5.5e-07 29.4 0.5 3.1 4 0 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolases FliJ PF02050.16 CDW53651.1 - 0.012 15.9 1.8 0.85 9.9 0.1 2.6 2 0 0 2 2 2 0 Flagellar FliJ protein HR1 PF02185.16 CDW53651.1 - 0.43 10.7 9.2 1.8 8.8 2.5 2.7 2 0 0 2 2 2 0 Hr1 repeat TPT PF03151.16 CDW53652.1 - 7.4e-13 48.5 19.7 1.2e-09 38.0 8.8 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family IPP-2 PF04979.14 CDW53653.1 - 3.1e-31 108.9 3.3 4.3e-31 108.4 3.3 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Pkinase PF00069.25 CDW53654.1 - 1.8e-43 148.8 0.0 4.6e-22 78.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53654.1 - 2.9e-12 46.4 0.0 1.2e-08 34.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW53654.1 - 0.0014 17.5 0.0 0.0017 17.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CDW53654.1 - 0.0025 17.4 0.1 0.0048 16.5 0.1 1.4 1 0 0 1 1 1 1 RIO1 family MotB_plug PF13677.6 CDW53655.1 - 0.68 9.6 0.0 0.68 9.6 0.0 2.0 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB Reticulon PF02453.17 CDW53656.1 - 9.7e-10 38.6 1.3 1.6e-09 37.9 1.3 1.3 1 0 0 1 1 1 1 Reticulon PUF PF00806.19 CDW53657.1 - 5.2e-70 227.4 14.9 3.5e-10 39.0 0.0 8.3 7 1 1 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 CDW53657.1 - 9.7e-08 32.5 3.2 0.12 12.7 0.1 4.8 2 1 3 5 5 5 2 CPL (NUC119) domain LOB PF03195.14 CDW53657.1 - 0.00047 20.7 2.5 7.1 7.3 0.1 5.1 2 1 2 5 5 5 1 Lateral organ boundaries (LOB) domain LuxT_C PF18285.1 CDW53657.1 - 0.00059 20.3 0.3 0.049 14.2 0.0 2.9 3 1 0 3 3 2 1 Tetracycline repressor LuxT C-terminal domain sCache_2 PF17200.4 CDW53657.1 - 0.0041 17.0 0.6 1.4 8.8 0.0 3.9 4 1 1 5 5 5 1 Single Cache domain 2 DUF445 PF04286.12 CDW53657.1 - 0.005 16.7 1.4 0.039 13.7 0.2 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF445) HNOB PF07700.15 CDW53657.1 - 0.0094 15.9 1.3 11 6.0 0.0 3.7 2 2 0 3 3 3 1 Haem-NO-binding MgtE_N PF03448.17 CDW53657.1 - 0.016 15.8 0.4 8.2 7.1 0.0 3.9 5 0 0 5 5 5 0 MgtE intracellular N domain Rad50_zn_hook PF04423.14 CDW53657.1 - 0.12 12.2 2.4 11 6.0 0.2 3.6 3 0 0 3 3 3 0 Rad50 zinc hook motif Importin_rep_3 PF18806.1 CDW53657.1 - 0.16 12.1 0.5 4.1 7.5 0.1 3.3 1 1 1 3 3 3 0 Importin 13 repeat TEX33 PF15400.6 CDW53657.1 - 0.17 12.4 1.7 14 6.2 0.1 3.6 2 1 2 4 4 4 0 Testis-expressed sequence 33 protein family DUF234 PF03008.14 CDW53657.1 - 0.21 12.1 2.1 13 6.3 0.2 3.6 3 1 1 4 4 4 0 Archaea bacterial proteins of unknown function ParD PF09386.10 CDW53657.1 - 1.1 9.7 5.9 29 5.1 0.1 4.5 4 2 1 5 5 5 0 Antitoxin ParD DUF2524 PF10732.9 CDW53657.1 - 5.4 7.4 8.7 45 4.4 1.6 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF2524) DUF3357 PF11837.8 CDW53658.1 - 0.022 15.2 0.1 11 6.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3357) zf-C2H2 PF00096.26 CDW53659.1 - 7.4e-12 45.0 28.8 0.0002 21.6 0.2 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW53659.1 - 2.6e-07 30.9 28.7 0.02 15.7 2.1 4.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW53659.1 - 0.00047 20.5 25.8 0.00065 20.0 0.4 5.3 5 0 0 5 5 5 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW53659.1 - 0.0011 19.1 15.0 0.14 12.5 0.5 3.9 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW53659.1 - 0.0065 16.8 18.2 1.4 9.4 0.1 4.0 4 0 0 4 4 3 3 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 CDW53659.1 - 0.011 16.5 7.2 3.6 8.3 0.7 4.1 3 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 CDW53659.1 - 0.043 14.2 15.0 1.1 9.6 0.1 5.1 3 1 2 5 5 5 0 C2H2 type zinc-finger (2 copies) BolA PF01722.18 CDW53659.1 - 0.044 14.1 1.2 0.085 13.2 0.2 2.0 2 0 0 2 2 2 0 BolA-like protein Viral_DNA_bp PF00747.17 CDW53659.1 - 0.061 10.5 0.2 0.15 9.2 0.0 1.6 2 0 0 2 2 2 0 ssDNA binding protein DZR PF12773.7 CDW53659.1 - 0.11 12.6 2.2 0.92 9.6 0.4 2.7 2 1 0 2 2 2 0 Double zinc ribbon Tropomyosin_1 PF12718.7 CDW53659.1 - 0.13 12.5 0.3 0.44 10.7 0.1 1.9 2 0 0 2 2 2 0 Tropomyosin like zf_UBZ PF18439.1 CDW53659.1 - 0.21 11.2 9.6 4.8 6.9 0.2 4.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_15 PF17032.5 CDW53659.1 - 0.29 11.9 5.7 3.8 8.3 2.6 3.1 2 1 1 3 3 3 0 zinc-ribbon family zf-MYST PF17772.1 CDW53659.1 - 0.38 10.4 9.5 20 4.9 0.1 4.2 3 1 1 4 4 4 0 MYST family zinc finger domain GAGA PF09237.11 CDW53659.1 - 1.3 8.8 9.4 2.1 8.2 1.4 3.2 2 1 1 3 3 3 0 GAGA factor Mut7-C PF01927.16 CDW53659.1 - 1.4 9.0 4.3 10 6.2 0.5 3.5 3 1 1 4 4 4 0 Mut7-C RNAse domain zinc-ribbons_6 PF07191.12 CDW53659.1 - 1.8 8.6 6.3 7.5 6.6 0.1 3.3 2 1 0 2 2 2 0 zinc-ribbons LIM PF00412.22 CDW53659.1 - 3.5 7.9 11.4 3.1 8.1 6.4 2.5 2 0 0 2 2 2 0 LIM domain C1_1 PF00130.22 CDW53659.1 - 8.8 6.3 13.1 27 4.7 0.1 3.7 2 1 2 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2428 PF10350.9 CDW53660.1 - 1.3e-26 93.5 4.4 1.8e-26 93.0 0.1 2.3 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 CDW53660.1 - 0.015 15.5 0.6 14 6.2 0.1 4.5 3 0 0 3 3 3 0 HEAT repeat HRG PF16954.5 CDW53661.1 - 3.4e-11 43.4 5.3 3.4e-11 43.4 5.3 3.1 2 1 1 3 3 3 1 Haem-transporter, endosomal/lysosomal, haem-responsive gene DUF3767 PF12597.8 CDW53661.1 - 0.15 11.9 6.8 1.5 8.7 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3767) Ycf66_N PF07444.11 CDW53661.1 - 4 7.6 9.8 72 3.6 9.1 2.8 1 1 0 1 1 1 0 Ycf66 protein N-terminus VirB3 PF05101.13 CDW53661.1 - 4.5 7.6 15.6 2.2 8.6 3.9 2.2 1 1 1 2 2 2 0 Type IV secretory pathway, VirB3-like protein MH2 PF03166.14 CDW53662.1 - 6e-74 248.3 1.2 1.5e-72 243.7 0.1 2.2 2 0 0 2 2 2 1 MH2 domain MH1 PF03165.16 CDW53662.1 - 2.4e-39 133.7 2.6 5.6e-39 132.5 2.6 1.6 1 0 0 1 1 1 1 MH1 domain TFIIA PF03153.13 CDW53662.1 - 0.0037 17.3 7.4 0.005 16.9 7.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 CDW53662.1 - 0.005 15.9 7.1 0.0068 15.4 7.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Activator_LAG-3 PF11498.8 CDW53662.1 - 0.011 14.8 17.1 0.016 14.2 17.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Spt20 PF12090.8 CDW53662.1 - 0.058 13.0 14.9 0.09 12.4 14.9 1.2 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 CDW53662.1 - 0.52 9.1 13.4 0.84 8.4 13.4 1.2 1 0 0 1 1 1 0 Androgen receptor Glyco_hydro_38N PF01074.22 CDW53663.1 - 3.1e-75 253.2 0.0 4.8e-75 252.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 CDW53663.1 - 2.8e-50 171.3 0.0 4.8e-50 170.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 CDW53663.1 - 3e-20 72.2 0.0 6.2e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 CDW53663.1 - 5.6e-07 29.6 0.0 1.4e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain ubiquitin PF00240.23 CDW53663.1 - 0.0034 17.1 0.0 0.012 15.3 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 CDW53663.1 - 0.12 12.8 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Peptidase_M1 PF01433.20 CDW53664.1 - 1.4e-70 237.2 2.6 1.1e-69 234.3 2.6 2.5 1 1 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 CDW53664.1 - 2.2e-61 208.2 0.0 4.1e-60 204.0 0.0 2.6 2 1 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 CDW53664.1 - 4.9e-49 167.0 1.1 2e-48 165.1 0.3 2.3 2 1 0 2 2 2 1 Peptidase M1 N-terminal domain DUF45 PF01863.17 CDW53664.1 - 0.038 14.0 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF45 AA_permease PF00324.21 CDW53665.1 - 1.6e-38 132.5 41.3 6e-38 130.7 31.0 2.1 2 0 0 2 2 2 2 Amino acid permease Indigoidine_A PF04227.12 CDW53666.1 - 2.4e-111 371.8 1.1 3.2e-111 371.4 1.1 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 CDW53666.1 - 9e-26 90.9 0.0 2.4e-25 89.5 0.0 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase TPP_enzyme_N PF02776.18 CDW53666.1 - 0.0041 16.7 0.3 0.0089 15.7 0.3 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Sec16_C PF12931.7 CDW53667.1 - 1.6e-25 90.4 0.1 3.4e-25 89.3 0.1 1.5 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 CDW53667.1 - 2.4e-09 37.8 0.0 8.8e-09 36.0 0.0 2.1 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region zf-C2H2 PF00096.26 CDW53668.1 - 7e-14 51.4 80.4 0.001 19.4 5.5 9.6 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 CDW53668.1 - 1.6e-11 43.7 69.9 9.8e-06 25.2 2.6 7.4 8 0 0 8 8 8 5 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 CDW53668.1 - 1.6e-06 28.2 57.9 0.0002 21.6 6.5 8.7 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW53668.1 - 0.0001 22.8 72.2 0.072 14.0 1.9 9.5 9 0 0 9 9 9 5 C2H2-type zinc finger Polysacc_lyase PF14099.6 CDW53668.1 - 0.0082 16.0 0.2 0.015 15.1 0.2 1.4 1 0 0 1 1 1 1 Polysaccharide lyase SUIM_assoc PF16619.5 CDW53668.1 - 0.073 13.2 8.9 0.043 13.9 2.3 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Methyltransf_PK PF05891.12 CDW53669.1 - 1.1e-70 237.6 0.0 1.8e-70 236.9 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase CutA1 PF03091.15 CDW53669.1 - 1.4e-31 108.3 0.5 8.5e-31 105.7 0.0 2.3 2 0 0 2 2 2 1 CutA1 divalent ion tolerance protein Methyltransf_25 PF13649.6 CDW53669.1 - 2.9e-08 34.3 0.0 7.9e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW53669.1 - 9.1e-06 26.2 0.0 2.1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW53669.1 - 0.00011 22.8 0.0 0.00023 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CDW53669.1 - 0.0057 16.0 0.0 0.0099 15.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain BTB PF00651.31 CDW53669.1 - 0.0091 16.2 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain MTS PF05175.14 CDW53669.1 - 0.0097 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 CDW53669.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CDW53669.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 CDW53670.1 - 9.7e-17 60.9 41.6 7.8e-16 57.9 41.9 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily JAMP PF05571.12 CDW53671.1 - 3.1e-74 250.2 30.6 7.5e-54 183.3 20.5 2.2 1 1 1 2 2 2 2 JNK1/MAPK8-associated membrane protein zf-RING_2 PF13639.6 CDW53672.1 - 5.1e-12 45.9 7.7 5.1e-12 45.9 7.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CDW53672.1 - 1.1e-10 41.0 2.9 1.1e-10 41.0 2.9 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDW53672.1 - 6.2e-07 29.2 5.5 6.2e-07 29.2 5.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDW53672.1 - 1.9e-06 27.6 7.2 1.9e-06 27.6 7.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW53672.1 - 7.1e-06 25.9 5.4 7.1e-06 25.9 5.4 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDW53672.1 - 1.3e-05 25.1 1.9 0.00062 19.7 1.6 2.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 CDW53672.1 - 1.9e-05 24.9 10.2 0.00019 21.6 10.2 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDW53672.1 - 8.9e-05 22.3 5.4 8.9e-05 22.3 5.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) LRR19-TM PF15176.6 CDW53672.1 - 0.0033 17.4 0.0 0.0081 16.1 0.0 1.6 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain Prok-RING_4 PF14447.6 CDW53672.1 - 0.0051 16.6 5.0 0.0051 16.6 5.0 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CDW53672.1 - 0.033 14.2 4.0 0.038 14.0 2.3 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3H2C3 PF17122.5 CDW53672.1 - 0.075 13.1 5.4 0.46 10.6 5.4 2.4 1 1 0 1 1 1 0 Zinc-finger Nramp PF01566.18 CDW53672.1 - 0.2 10.6 0.1 0.32 9.9 0.1 1.2 1 0 0 1 1 1 0 Natural resistance-associated macrophage protein Prok-RING_1 PF14446.6 CDW53672.1 - 1.4 8.9 7.5 4.2 7.4 3.2 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 CI-B14_5a PF07347.12 CDW53673.1 - 4.8e-19 68.0 0.1 5.8e-19 67.8 0.1 1.3 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) SSF PF00474.17 CDW53674.1 - 2.3e-38 132.1 55.3 5.4e-22 78.2 30.3 2.2 2 0 0 2 2 2 2 Sodium:solute symporter family Wzy_C PF04932.15 CDW53674.1 - 0.0038 16.9 0.0 0.0038 16.9 0.0 4.9 4 3 0 4 4 4 1 O-Antigen ligase DUF3450 PF11932.8 CDW53674.1 - 0.068 12.5 0.1 3.4 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Sugar_tr PF00083.24 CDW53675.1 - 6.6e-15 54.9 18.3 3.7e-13 49.1 18.3 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW53675.1 - 3.1e-14 52.7 23.8 6.7e-14 51.6 23.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Ion_trans PF00520.31 CDW53676.1 - 2.9e-124 413.1 94.2 1.3e-35 122.8 15.8 4.2 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 CDW53676.1 - 0.00092 18.0 70.2 0.023 13.4 9.8 6.4 6 0 0 6 6 6 5 Polycystin cation channel PsaF PF17550.2 CDW53676.1 - 0.42 10.1 6.7 1.1 8.7 0.5 3.5 3 0 0 3 3 3 0 Family of unknown function PAP2_C PF14360.6 CDW53677.1 - 5e-18 65.4 6.3 5e-18 65.4 6.3 2.3 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 CDW53677.1 - 2.4e-07 30.6 2.4 2.4e-07 30.6 2.4 2.7 3 0 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 CDW53677.1 - 0.0022 17.7 9.6 0.0061 16.3 9.6 1.7 1 1 0 1 1 1 1 PAP2 superfamily Wzy_C PF04932.15 CDW53677.1 - 4 7.0 7.6 4.5 6.9 0.3 2.7 3 0 0 3 3 3 0 O-Antigen ligase Ins_P5_2-kin PF06090.12 CDW53678.1 - 1.7e-52 178.9 0.1 2.2e-52 178.6 0.1 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DEAD PF00270.29 CDW53679.1 - 1.3e-34 119.5 0.1 4.7e-34 117.7 0.0 2.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW53679.1 - 8.4e-22 77.6 0.0 2e-21 76.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDW53679.1 - 1.8e-13 50.5 0.0 4.7e-13 49.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CDW53679.1 - 5.3e-08 33.1 0.0 1.8e-07 31.3 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CDW53679.1 - 0.0023 18.2 0.0 0.36 11.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain UTP25 PF06862.12 CDW53679.1 - 0.0026 16.6 0.0 0.019 13.8 0.0 2.0 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Helicase_C_2 PF13307.6 CDW53679.1 - 0.013 15.6 0.5 0.17 12.0 0.1 2.4 3 0 0 3 3 3 0 Helicase C-terminal domain SBF_like PF13593.6 CDW53679.1 - 0.062 12.6 0.1 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 SBF-like CPA transporter family (DUF4137) Pou PF00157.17 CDW53681.1 - 1.6e-22 79.2 0.1 3.1e-22 78.3 0.1 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeobox_KN PF05920.11 CDW53681.1 - 2.8e-06 27.1 0.0 6.5e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 CDW53681.1 - 2.9e-06 27.0 0.0 8.5e-06 25.5 0.0 1.8 1 0 0 1 1 1 1 Homeodomain HMG_box_2 PF09011.10 CDW53682.1 - 1.7e-09 38.1 7.4 0.00014 22.4 0.3 3.3 3 0 0 3 3 3 2 HMG-box domain HMG_box PF00505.19 CDW53682.1 - 1.2e-06 28.9 5.4 0.014 15.8 1.1 2.7 2 0 0 2 2 2 2 HMG (high mobility group) box Phe_tRNA-synt_N PF02912.18 CDW53682.1 - 0.002 18.0 2.7 8.4 6.4 0.3 3.4 3 0 0 3 3 3 2 Aminoacyl tRNA synthetase class II, N-terminal domain DUF3106 PF11304.8 CDW53682.1 - 0.0037 17.7 5.9 0.11 12.9 1.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF3106) NPV_P10 PF05531.12 CDW53682.1 - 0.44 11.0 2.4 5.8 7.5 0.3 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein YtxH PF12732.7 CDW53682.1 - 1.4 9.5 4.6 28 5.4 0.6 3.0 2 1 0 2 2 2 0 YtxH-like protein Methyltransf_28 PF02636.17 CDW53683.1 - 1.2e-64 218.5 0.0 1.5e-64 218.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Abhydrolase_6 PF12697.7 CDW53684.1 - 9.6e-26 91.7 0.0 1.2e-25 91.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDW53684.1 - 7e-05 22.6 1.3 0.00018 21.2 1.3 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 CDW53684.1 - 9.6e-05 22.2 0.3 0.00016 21.5 0.3 1.3 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 CDW53684.1 - 0.00022 20.6 0.8 0.00043 19.6 0.6 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CDW53684.1 - 0.00032 20.6 0.2 0.00049 20.0 0.2 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 CDW53684.1 - 0.00044 19.3 0.0 0.00065 18.7 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Thioesterase PF00975.20 CDW53684.1 - 0.00095 19.3 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 CDW53684.1 - 0.0088 15.9 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_2 PF02230.16 CDW53684.1 - 0.013 15.3 0.3 2 8.2 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase LIDHydrolase PF10230.9 CDW53684.1 - 0.015 14.9 0.2 1 8.9 0.2 2.1 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 CDW53684.1 - 0.027 14.2 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3530 PF12048.8 CDW53684.1 - 0.13 11.7 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Chlorophyllase PF07224.11 CDW53684.1 - 0.16 11.0 0.1 0.32 10.0 0.1 1.5 1 0 0 1 1 1 0 Chlorophyllase Pkinase_Tyr PF07714.17 CDW53685.1 - 2.4e-33 115.5 0.0 3.5e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 CDW53685.1 - 4.8e-27 93.7 12.3 8.9e-12 45.0 1.5 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW53685.1 - 6.3e-22 77.7 1.7 4.7e-12 46.2 0.4 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW53685.1 - 9.1e-22 77.5 1.9 1.3e-16 60.9 0.7 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Pkinase PF00069.25 CDW53685.1 - 2.4e-20 73.0 0.0 6.4e-20 71.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Ank PF00023.30 CDW53685.1 - 2e-18 66.0 7.2 3.5e-05 24.1 0.1 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 CDW53685.1 - 2.8e-16 58.0 1.1 0.00013 22.1 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Sod_Cu PF00080.20 CDW53686.1 - 9.2e-45 152.3 1.2 1.1e-44 152.1 1.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CUB PF00431.20 CDW53687.1 - 0 1309.4 43.3 5.9e-29 100.6 0.0 28.9 28 2 0 28 28 28 26 CUB domain EGF PF00008.27 CDW53687.1 - 1e-26 92.8 117.8 6.2e-07 29.6 9.0 8.9 8 0 0 8 8 8 7 EGF-like domain CUB_2 PF02408.20 CDW53687.1 - 1.8e-18 66.4 46.1 0.03 14.1 0.0 17.4 19 1 1 20 20 20 7 CUB-like domain EGF_CA PF07645.15 CDW53687.1 - 7.8e-14 51.6 111.7 2.5e-07 30.8 8.5 9.7 7 3 2 9 9 9 4 Calcium-binding EGF domain hEGF PF12661.7 CDW53687.1 - 5.2e-10 39.6 96.9 0.00064 20.3 3.2 9.7 9 1 0 9 9 9 6 Human growth factor-like EGF FXa_inhibition PF14670.6 CDW53687.1 - 0.00069 19.9 10.4 0.00069 19.9 10.4 9.0 7 1 1 8 8 8 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW53687.1 - 0.0015 18.7 10.5 0.0015 18.7 10.5 9.1 8 0 0 8 8 8 4 EGF domain cEGF PF12662.7 CDW53687.1 - 0.0033 17.3 2.0 0.0033 17.3 2.0 9.7 8 0 0 8 8 8 4 Complement Clr-like EGF-like Propeptide_C1 PF08127.13 CDW53687.1 - 0.22 11.5 0.5 0.59 10.1 0.5 1.7 1 0 0 1 1 1 0 Peptidase family C1 propeptide LRR_8 PF13855.6 CDW53689.1 - 3.6e-22 77.9 22.3 2.4e-11 43.2 4.8 4.7 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 CDW53689.1 - 9.4e-17 60.9 26.5 0.0001 22.6 1.0 5.3 3 1 1 5 5 5 4 Leucine Rich repeats (2 copies) B3_4 PF03483.17 CDW53689.1 - 8.5e-06 25.5 0.1 8.7e-05 22.3 0.0 2.6 3 0 0 3 3 3 1 B3/4 domain LRR_6 PF13516.6 CDW53689.1 - 1.5e-05 24.6 18.6 2.8 8.2 0.2 6.7 6 0 0 6 6 6 4 Leucine Rich repeat LRR_1 PF00560.33 CDW53689.1 - 0.00023 21.3 19.0 3.7 8.5 0.1 7.4 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 CDW53689.1 - 0.0011 18.4 5.0 0.25 10.8 0.7 3.0 1 1 2 3 3 3 3 Leucine-rich repeat DUF773 PF05600.12 CDW53690.1 - 8.9e-124 414.0 4.1 1.8e-122 409.7 4.1 2.3 1 1 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 Ead_Ea22 PF13935.6 CDW53690.1 - 0.0014 19.3 3.2 0.24 12.1 0.7 2.8 2 0 0 2 2 2 1 Ead/Ea22-like protein Atg14 PF10186.9 CDW53690.1 - 0.0099 15.0 0.8 0.025 13.7 0.8 1.6 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 CDW53690.1 - 0.048 12.5 5.2 0.27 10.1 1.2 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 CDW53690.1 - 0.06 13.7 4.0 1.6 9.1 0.4 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TelA PF05816.11 CDW53690.1 - 0.1 11.6 2.3 0.12 11.4 0.2 1.9 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) GYF PF02213.16 CDW53690.1 - 0.11 12.2 0.1 0.37 10.5 0.1 1.8 1 0 0 1 1 1 0 GYF domain kleA_kleC PF17383.2 CDW53690.1 - 0.23 11.8 2.9 0.44 10.9 1.2 2.3 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A COG5 PF10392.9 CDW53690.1 - 0.3 11.2 5.2 0.26 11.5 0.2 3.2 4 1 0 4 4 4 0 Golgi transport complex subunit 5 Taxilin PF09728.9 CDW53690.1 - 0.34 10.1 4.1 5.7 6.0 0.4 2.3 2 0 0 2 2 2 0 Myosin-like coiled-coil protein MscS_porin PF12795.7 CDW53690.1 - 0.34 10.4 3.1 1.1 8.7 0.2 2.4 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain Laminin_II PF06009.12 CDW53690.1 - 0.52 10.3 3.7 0.62 10.1 1.2 2.3 3 0 0 3 3 3 0 Laminin Domain II TMF_TATA_bd PF12325.8 CDW53690.1 - 1 9.6 5.2 1.5 9.1 0.8 3.0 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 CDW53690.1 - 2.2 8.8 4.9 0.9 10.0 1.3 2.2 2 0 0 2 2 2 0 Cell division protein ZapB TPR_MLP1_2 PF07926.12 CDW53690.1 - 2.5 8.2 8.4 0.23 11.5 1.1 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein ABC_tran_CTD PF16326.5 CDW53690.1 - 3.1 8.1 5.6 23 5.3 0.2 3.3 3 1 0 3 3 3 0 ABC transporter C-terminal domain KASH_CCD PF14662.6 CDW53690.1 - 8.7 6.1 7.8 0.39 10.5 0.7 2.3 3 0 0 3 3 2 0 Coiled-coil region of CCDC155 or KASH DUF4061 PF13270.6 CDW53691.1 - 5.2e-06 26.7 3.2 8.3e-06 26.0 3.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) LRRFIP PF09738.9 CDW53691.1 - 7.3e-05 22.4 3.9 8.1e-05 22.2 3.9 1.0 1 0 0 1 1 1 1 LRRFIP family TcdB_N PF12918.7 CDW53691.1 - 0.0037 17.5 0.1 0.0071 16.6 0.1 1.5 1 0 0 1 1 1 1 TcdB toxin N-terminal helical domain HAUS6_N PF14661.6 CDW53691.1 - 0.022 14.4 0.7 0.023 14.3 0.7 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus FemAB_like PF04339.12 CDW53691.1 - 0.13 11.3 0.4 0.15 11.1 0.4 1.0 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition WD40 PF00400.32 CDW53692.1 - 8e-12 45.5 7.7 0.017 16.0 0.1 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53692.1 - 0.061 13.6 0.0 11 6.4 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PNP_UDP_1 PF01048.20 CDW53693.1 - 3.2e-07 29.8 0.0 3.6e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily PNP_UDP_1 PF01048.20 CDW53694.1 - 6.1e-30 104.2 0.3 7.2e-17 61.4 0.0 2.8 2 1 0 2 2 2 2 Phosphorylase superfamily YsaB PF13983.6 CDW53694.1 - 0.13 12.6 1.0 19 5.6 0.2 2.8 2 0 0 2 2 2 0 YsaB-like lipoprotein 2-Hacid_dh_C PF02826.19 CDW53694.1 - 0.17 11.2 0.1 0.34 10.2 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF5396 PF17374.2 CDW53694.1 - 0.27 9.1 0.0 0.38 8.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5396) Ras PF00071.22 CDW53696.1 - 3.9e-14 52.6 0.0 4.5e-14 52.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW53696.1 - 1.4e-06 28.5 0.0 2.1e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CDW53696.1 - 5.1e-05 23.4 0.2 0.00012 22.2 0.1 1.7 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CDW53696.1 - 5.9e-05 23.1 0.0 8.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CDW53696.1 - 9.7e-05 21.9 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW53696.1 - 0.00078 19.0 0.0 0.0012 18.4 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDW53696.1 - 0.0026 17.1 0.2 0.0037 16.6 0.2 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region OS-D PF03392.13 CDW53696.1 - 0.035 14.2 1.1 0.059 13.5 1.1 1.5 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D DAP3 PF10236.9 CDW53696.1 - 0.1 11.7 0.6 10 5.2 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.6 CDW53696.1 - 0.17 11.9 0.1 0.45 10.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain Spindle_Spc25 PF08234.12 CDW53697.1 - 6e-11 42.4 0.1 4.1e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 FliE PF02049.18 CDW53697.1 - 0.089 12.9 0.3 0.35 11.0 0.2 1.9 1 1 1 2 2 2 0 Flagellar hook-basal body complex protein FliE Glyco_trans_4_4 PF13579.6 CDW53698.1 - 7.6e-10 39.5 0.1 1.4e-09 38.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CDW53698.1 - 3.8e-09 37.1 0.0 8e-09 36.0 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDW53698.1 - 3.6e-07 29.9 0.0 7.3e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDW53698.1 - 1.7e-06 28.2 0.1 3.1e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDW53698.1 - 0.00099 19.5 0.0 0.0018 18.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 COX17 PF05051.13 CDW53699.1 - 2.6e-21 75.7 7.5 3.2e-21 75.4 7.5 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Sec20 PF03908.13 CDW53700.1 - 3.7e-13 49.2 3.1 4.8e-13 48.8 1.4 2.0 2 0 0 2 2 2 1 Sec20 Zw10 PF06248.13 CDW53700.1 - 0.00048 18.8 0.3 0.00081 18.1 0.3 1.3 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Synaptobrevin PF00957.21 CDW53700.1 - 0.012 15.4 2.1 0.016 15.0 0.5 2.1 2 1 0 2 2 2 0 Synaptobrevin CENP-Q PF13094.6 CDW53700.1 - 0.017 15.3 2.0 0.046 13.9 2.0 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DASH_Duo1 PF08651.10 CDW53700.1 - 0.02 14.6 0.2 8.7 6.2 0.0 2.6 2 1 0 2 2 2 0 DASH complex subunit Duo1 Fib_alpha PF08702.10 CDW53700.1 - 0.062 13.5 0.3 8.1 6.6 0.1 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TACC_C PF05010.14 CDW53700.1 - 0.068 13.0 0.8 0.3 10.9 0.3 2.0 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal BORCS8 PF10167.9 CDW53700.1 - 0.16 11.9 0.6 31 4.6 0.0 2.9 2 1 0 3 3 3 0 BLOC-1-related complex sub-unit 8 Innexin PF00876.18 CDW53701.1 - 7.1e-127 423.5 16.1 8.4e-127 423.3 16.1 1.0 1 0 0 1 1 1 1 Innexin TIP41 PF04176.13 CDW53704.1 - 4.1e-48 163.1 0.0 5.2e-48 162.8 0.0 1.1 1 0 0 1 1 1 1 TIP41-like family DUF498 PF04430.14 CDW53707.1 - 7.3e-21 74.3 0.0 2.4e-20 72.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF498/DUF598) Carn_acyltransf PF00755.20 CDW53708.1 - 4.5e-182 606.8 0.0 5.1e-182 606.6 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase NPR3 PF03666.13 CDW53709.1 - 7.7e-37 127.2 1.5 8e-35 120.5 0.7 2.7 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 CDW53709.1 - 0.00086 18.2 1.1 0.0082 14.9 1.1 2.1 1 1 0 1 1 1 1 Nitrogen permease regulator 2 EMC3_TMCO1 PF01956.16 CDW53710.1 - 2.5e-51 173.8 1.4 2.5e-51 173.8 1.4 1.7 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like Homeodomain PF00046.29 CDW53711.1 - 1.5e-19 69.5 8.2 2.5e-19 68.8 8.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW53711.1 - 0.0083 16.0 0.1 0.017 15.0 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain MiaE_2 PF13794.6 CDW53711.1 - 0.042 13.5 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like 7tm_1 PF00001.21 CDW53712.1 - 1.1e-11 44.6 13.3 5.8e-10 38.9 13.3 2.1 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 CDW53712.1 - 1.9e-07 30.7 13.2 0.00017 21.0 7.7 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 CDW53712.1 - 1.9e-05 24.2 10.8 0.00022 20.7 5.2 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx TauE PF01925.19 CDW53713.1 - 0.0078 15.9 1.6 0.01 15.5 0.9 1.4 1 1 0 1 1 1 1 Sulfite exporter TauE/SafE Forkhead PF00250.18 CDW53714.1 - 3.7e-26 91.2 1.5 8.3e-25 86.9 0.3 2.8 2 1 0 2 2 2 1 Forkhead domain Ribosomal_L14 PF00238.19 CDW53715.1 - 1.9e-37 128.1 0.4 2.2e-37 127.8 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e UBA_4 PF14555.6 CDW53716.1 - 9.3e-07 28.6 0.1 1.8e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain Exo_endo_phos PF03372.23 CDW53716.1 - 0.017 14.7 0.0 0.066 12.7 0.0 2.0 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family TAP_C PF03943.13 CDW53716.1 - 0.1 12.3 0.1 0.22 11.2 0.1 1.6 1 0 0 1 1 1 0 TAP C-terminal domain Synapsin_C PF02750.14 CDW53717.1 - 2.5e-68 229.6 0.0 3.4e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 CDW53717.1 - 1.1e-25 89.8 0.0 3.4e-25 88.3 0.0 1.8 1 1 0 1 1 1 1 Synapsin, N-terminal domain Peptidase_C12 PF01088.21 CDW53718.1 - 3.8e-47 160.8 0.0 4.4e-47 160.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 KAP_NTPase PF07693.14 CDW53719.1 - 3.3e-60 204.1 0.0 4.9e-60 203.5 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain Ank_2 PF12796.7 CDW53719.1 - 2.2e-58 194.8 2.0 1.2e-15 57.8 0.0 5.5 3 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW53719.1 - 7.2e-50 166.8 2.6 4e-09 36.8 0.0 8.6 3 2 6 9 9 9 9 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW53719.1 - 1e-48 162.7 13.2 1.3e-09 38.1 0.1 9.6 2 2 8 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW53719.1 - 1.6e-42 138.6 7.8 0.019 15.4 0.0 12.1 11 0 0 11 11 11 11 Ankyrin repeat Ank PF00023.30 CDW53719.1 - 3.5e-39 131.5 5.8 0.00043 20.6 0.0 11.5 11 0 0 11 11 11 9 Ankyrin repeat DotU PF09850.9 CDW53719.1 - 0.0028 17.4 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 Type VI secretion system protein DotU EI24 PF07264.11 CDW53719.1 - 0.007 16.6 2.4 0.007 16.6 2.4 1.8 2 0 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) MgtE PF01769.16 CDW53719.1 - 0.17 12.2 2.7 0.43 11.0 2.7 1.6 1 0 0 1 1 1 0 Divalent cation transporter Acyltransferase PF01553.21 CDW53720.1 - 2e-22 79.3 0.1 2.3e-22 79.1 0.1 1.1 1 0 0 1 1 1 1 Acyltransferase ATP_bind_3 PF01171.20 CDW53721.1 - 1e-05 25.4 0.0 1.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 PP-loop family PAPS_reduct PF01507.19 CDW53721.1 - 0.091 12.8 0.0 0.11 12.5 0.0 1.3 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family TF_Zn_Ribbon PF08271.12 CDW53721.1 - 0.49 10.0 3.8 0.83 9.2 0.3 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding 6PF2K PF01591.18 CDW53722.1 - 7.3e-86 287.1 1.2 8.1e-86 286.9 0.4 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CDW53722.1 - 2.2e-42 145.0 0.0 3.2e-42 144.4 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) zn-ribbon_14 PF16503.5 CDW53722.1 - 8e-10 38.1 2.6 1.9e-09 36.8 2.6 1.6 1 0 0 1 1 1 1 Zinc-ribbon AAA_33 PF13671.6 CDW53722.1 - 2.3e-06 27.9 0.0 4e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 CDW53722.1 - 0.0019 17.7 0.0 0.0031 17.0 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 APS_kinase PF01583.20 CDW53722.1 - 0.041 13.8 0.0 0.11 12.4 0.0 1.7 1 1 0 1 1 1 0 Adenylylsulphate kinase Zeta_toxin PF06414.12 CDW53722.1 - 0.077 12.3 0.0 0.2 10.9 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin RecR PF02132.15 CDW53722.1 - 0.099 12.2 2.5 0.36 10.4 2.5 1.9 1 0 0 1 1 1 0 RecR protein ATP_bind_3 PF01171.20 CDW53722.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 PP-loop family Exo_endo_phos PF03372.23 CDW53723.1 - 2.9e-19 69.5 0.0 7.3e-19 68.2 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 CDW53723.1 - 5.9e-10 38.8 6.9 3.4e-06 26.7 0.8 2.7 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CDW53723.1 - 4.9e-08 33.1 6.8 0.00055 20.3 0.4 2.8 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) MCM PF00493.23 CDW53724.1 - 9.3e-100 332.3 0.0 1.4e-99 331.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDW53724.1 - 1.6e-34 118.4 0.7 3.1e-34 117.5 0.7 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDW53724.1 - 2e-27 95.4 4.0 3.1e-27 94.8 1.3 2.8 3 0 0 3 3 3 1 MCM AAA-lid domain MCM_N PF14551.6 CDW53724.1 - 8.4e-16 58.4 0.7 3.3e-15 56.5 0.0 2.3 2 0 0 2 2 2 1 MCM N-terminal domain MCM2_N PF12619.8 CDW53724.1 - 4.2e-15 56.4 5.9 4.2e-15 56.4 5.9 3.0 3 0 0 3 3 3 2 Mini-chromosome maintenance protein 2 Mg_chelatase PF01078.21 CDW53724.1 - 2.2e-08 33.7 0.1 5.7e-07 29.1 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDW53724.1 - 2.2e-06 27.5 0.0 0.00012 21.9 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW53724.1 - 3.3e-06 27.1 0.0 7.5e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDW53724.1 - 0.0043 16.8 0.0 0.47 10.1 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.29 CDW53724.1 - 0.0051 17.2 0.0 0.017 15.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_32 PF13654.6 CDW53724.1 - 0.013 14.3 0.4 0.38 9.5 0.2 2.5 3 0 0 3 3 3 0 AAA domain Sigma70_r3 PF04539.16 CDW53724.1 - 0.023 14.8 0.2 7.1 6.8 0.0 3.4 3 0 0 3 3 3 0 Sigma-70 region 3 Zn-ribbon_8 PF09723.10 CDW53724.1 - 0.039 14.1 0.9 0.1 12.7 0.9 1.7 1 0 0 1 1 1 0 Zinc ribbon domain AAA_lid_2 PF17863.1 CDW53724.1 - 0.049 13.5 0.2 0.17 11.7 0.1 1.9 2 0 0 2 2 2 0 AAA lid domain Pkinase PF00069.25 CDW53725.1 - 1.2e-23 83.9 0.0 1.5e-23 83.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53725.1 - 7.4e-11 41.8 0.0 1.1e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW53725.1 - 0.0037 16.1 0.0 0.0055 15.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase ATP-synt_S1 PF05827.12 CDW53726.1 - 1e-18 67.5 1.0 1.2e-18 67.3 1.0 1.1 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Erythro-docking PF09277.11 CDW53727.1 - 0.011 15.6 0.1 0.025 14.5 0.1 1.6 1 0 0 1 1 1 0 Erythronolide synthase, docking TSP_1 PF00090.19 CDW53728.1 - 6.2e-70 231.2 221.5 8.7e-08 32.3 10.7 19.0 19 0 0 19 19 19 15 Thrombospondin type 1 domain GON PF08685.11 CDW53728.1 - 1.3e-65 221.1 0.0 4.4e-65 219.3 0.0 2.0 1 0 0 1 1 1 1 GON domain ADAM_spacer1 PF05986.14 CDW53728.1 - 8.6e-28 96.7 0.1 1.3e-27 96.0 0.1 1.3 1 0 0 1 1 1 1 ADAM-TS Spacer 1 ADAM_CR_2 PF17771.1 CDW53728.1 - 7.6e-20 71.2 8.1 7.6e-20 71.2 8.1 8.6 7 2 3 10 10 10 2 ADAM cysteine-rich domain Reprolysin PF01421.19 CDW53728.1 - 4.1e-17 62.7 0.1 9.1e-17 61.6 0.1 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 CDW53728.1 - 3.6e-14 53.4 0.1 9.4e-14 52.0 0.1 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 CDW53728.1 - 1.8e-09 38.2 0.0 3.4e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CDW53728.1 - 1.1e-06 28.7 0.0 2.6e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CDW53728.1 - 0.0085 15.8 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like LSM PF01423.22 CDW53729.1 - 4.7e-14 51.8 0.3 6.8e-14 51.3 0.3 1.2 1 0 0 1 1 1 1 LSM domain DUF386 PF04074.12 CDW53729.1 - 0.17 11.8 0.0 0.2 11.6 0.0 1.1 1 0 0 1 1 1 0 YhcH/YjgK/YiaL NDUF_C2 PF06374.11 CDW53730.1 - 3.5e-14 52.9 0.0 4.1e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) DUF3792 PF12670.7 CDW53730.1 - 0.0018 18.4 0.1 0.0023 18.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3792) DUF5122 PF17164.4 CDW53730.1 - 0.37 11.1 1.3 1.3 9.4 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller Peptidase_C1 PF00112.23 CDW53731.1 - 9.9e-86 287.3 2.5 1.3e-85 286.9 2.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 CDW53731.1 - 2e-06 26.9 1.9 0.005 15.7 0.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family RFX_DNA_binding PF02257.15 CDW53732.1 - 7.5e-34 116.2 0.1 1.6e-33 115.2 0.1 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain MA3 PF02847.17 CDW53733.1 - 9.9e-23 80.3 1.9 2.3e-22 79.1 1.9 1.7 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 CDW53733.1 - 4.1e-13 49.5 0.2 4.1e-13 49.5 0.2 2.0 2 0 0 2 2 2 1 MIF4G domain Costars PF14705.6 CDW53733.1 - 0.087 13.0 0.2 0.7 10.1 0.0 2.4 2 0 0 2 2 2 0 Costars DAO PF01266.24 CDW53735.1 - 8.1e-50 170.4 0.0 1.2e-49 169.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 CDW53735.1 - 5.2e-39 133.0 0.0 1e-38 132.0 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.6 CDW53735.1 - 5.3e-12 46.0 1.1 1.1e-11 45.0 1.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 CDW53735.1 - 5.5e-09 34.9 0.7 0.0045 16.4 0.0 2.8 2 0 0 2 2 2 2 EF hand FAD_binding_2 PF00890.24 CDW53735.1 - 3e-08 33.2 1.7 0.00033 19.9 0.8 2.2 2 0 0 2 2 2 2 FAD binding domain EF-hand_6 PF13405.6 CDW53735.1 - 2.7e-07 30.0 0.4 0.018 14.9 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDW53735.1 - 7.9e-07 28.3 0.2 0.047 13.2 0.1 2.6 2 0 0 2 2 2 2 EF hand GIDA PF01134.22 CDW53735.1 - 3.1e-05 23.2 0.1 0.015 14.4 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A EF-hand_8 PF13833.6 CDW53735.1 - 5.1e-05 23.0 1.8 0.00047 19.9 0.6 2.4 1 1 1 2 2 2 2 EF-hand domain pair FAD_oxidored PF12831.7 CDW53735.1 - 0.00045 19.7 5.4 0.0014 18.1 1.1 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDW53735.1 - 0.004 16.4 0.1 0.01 15.1 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CDW53735.1 - 0.033 13.4 0.3 0.43 9.8 0.1 2.4 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 CDW53735.1 - 0.061 12.0 0.4 0.11 11.2 0.4 1.3 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_8 PF13450.6 CDW53735.1 - 0.09 13.0 0.1 0.37 11.1 0.2 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Transglut_C PF00927.22 CDW53736.1 - 4e-12 46.2 0.0 5.5e-08 32.9 0.0 2.4 2 0 0 2 2 2 2 Transglutaminase family, C-terminal ig like domain IL1 PF00340.19 CDW53736.1 - 0.053 13.2 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Interleukin-1 / 18 BatD PF13584.6 CDW53736.1 - 0.17 10.7 0.1 0.27 10.0 0.1 1.3 1 0 0 1 1 1 0 Oxygen tolerance Transglut_N PF00868.20 CDW53737.1 - 2.3e-26 92.5 0.0 3.5e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase family Transglut_core PF01841.19 CDW53737.1 - 2.9e-17 63.1 0.3 5.4e-17 62.3 0.3 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily tRNA-synt_1 PF00133.22 CDW53739.1 - 0.0038 15.5 0.0 0.0055 15.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1 PF00133.22 CDW53741.1 - 0.024 12.9 0.0 0.028 12.7 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) tRNA-synt_1 PF00133.22 CDW53742.1 - 1.8e-05 23.2 0.0 2.3e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Peptidase_A17 PF05380.13 CDW53743.1 - 1.7e-56 190.7 0.3 4.4e-56 189.4 0.3 1.8 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1758 PF05585.12 CDW53743.1 - 7.5e-15 55.1 0.0 1.5e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Putative peptidase (DUF1758) RVT_1 PF00078.27 CDW53743.1 - 7.5e-07 28.9 0.0 1.6e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 CDW53743.1 - 0.00051 20.6 0.1 0.0016 19.0 0.1 1.9 1 1 0 1 1 1 1 Aspartyl protease RT_RNaseH_2 PF17919.1 CDW53743.1 - 0.00075 19.5 0.0 0.009 16.0 0.0 2.5 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDW53743.1 - 0.0016 18.7 0.0 0.012 15.9 0.0 2.5 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Peptidase_A2B PF12384.8 CDW53743.1 - 0.015 14.9 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Ty3 transposon peptidase zf-CCHC PF00098.23 CDW53743.1 - 0.76 10.0 3.6 1.6 8.9 3.6 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_3 PF13917.6 CDW53743.1 - 1.3 9.1 5.6 1.3 9.0 3.1 2.2 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.27 CDW53745.1 - 7.5e-06 25.6 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) TBP PF00352.21 CDW53747.1 - 6.6e-36 122.1 0.1 3.3e-20 71.8 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) ubiquitin PF00240.23 CDW53747.1 - 4.7e-12 45.5 0.1 8.5e-12 44.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CDW53747.1 - 6.9e-05 22.7 0.1 0.00021 21.1 0.1 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 CDW53747.1 - 0.0018 18.4 0.0 0.0067 16.5 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 CDW53747.1 - 0.004 17.0 0.1 0.009 15.8 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF3378 PF11858.8 CDW53747.1 - 0.014 15.5 0.2 1.5 9.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) DUF2407 PF10302.9 CDW53747.1 - 0.04 14.5 0.1 0.16 12.6 0.0 2.0 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Elf4 PF07011.11 CDW53747.1 - 0.15 12.0 0.4 0.48 10.4 0.4 1.9 1 0 0 1 1 1 0 Early Flowering 4 domain Pex14_N PF04695.13 CDW53747.1 - 1 10.0 9.6 1.2 9.8 3.6 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CREPT PF16566.5 CDW53748.1 - 3.2e-31 108.5 6.5 5e-31 107.9 6.5 1.3 1 0 0 1 1 1 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.13 CDW53748.1 - 2.5e-14 53.8 0.8 7.6e-14 52.3 0.4 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CTK3 PF12243.8 CDW53748.1 - 0.004 17.2 0.3 0.0083 16.1 0.1 1.6 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 Phage_NinH PF06322.11 CDW53748.1 - 0.077 12.9 0.3 0.16 11.9 0.3 1.5 1 0 0 1 1 1 0 Phage NinH protein Ada3 PF10198.9 CDW53748.1 - 0.1 12.8 3.4 0.22 11.7 3.4 1.6 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 RecG_N PF17190.4 CDW53748.1 - 0.5 11.1 4.8 5.3 7.8 3.3 2.8 1 1 1 2 2 2 0 RecG N-terminal helical domain Colicin PF01024.19 CDW53748.1 - 0.57 10.0 2.1 1.9 8.3 2.2 1.7 2 0 0 2 2 2 0 Colicin pore forming domain Cortex-I_coil PF09304.10 CDW53748.1 - 6.2 7.1 11.6 2.8 8.2 1.4 2.9 2 2 2 4 4 4 0 Cortexillin I, coiled coil Peptidase_S9_N PF02897.15 CDW53749.1 - 1.5e-90 304.0 0.0 1.9e-90 303.6 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CDW53749.1 - 3.6e-56 190.0 0.0 5.4e-56 189.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CDW53749.1 - 0.0053 16.4 0.0 0.015 14.9 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Peptidase_S15 PF02129.18 CDW53749.1 - 0.016 14.8 0.0 0.042 13.4 0.0 1.7 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 CDW53749.1 - 0.027 13.7 0.0 0.2 10.9 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDW53749.1 - 0.1 12.2 0.0 0.4 10.3 0.0 1.9 1 1 1 2 2 2 0 alpha/beta hydrolase fold DLH PF01738.18 CDW53749.1 - 0.18 11.4 0.1 0.33 10.5 0.1 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family Sod_Fe_C PF02777.18 CDW53750.1 - 1.2e-39 134.6 0.0 2.4e-39 133.6 0.0 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CDW53750.1 - 1.2e-31 109.0 1.9 1.9e-31 108.4 1.9 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Calcipressin PF04847.12 CDW53751.1 - 1.6e-35 122.5 2.6 1.6e-34 119.3 2.6 1.9 1 1 0 1 1 1 1 Calcipressin PIP49_C PF12260.8 CDW53752.1 - 3e-29 102.0 0.6 5.3e-29 101.2 0.6 1.4 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 CDW53752.1 - 2.5e-06 27.4 2.6 3.3e-06 27.0 0.1 2.2 2 0 0 2 2 2 1 N-term cysteine-rich ER, FAM69 CCDC50_N PF15295.6 CDW53754.1 - 4.8e-18 65.5 14.1 4.8e-18 65.5 14.1 2.5 3 0 0 3 3 3 2 Coiled-coil domain-containing protein 50 N-terminus A_deaminase_N PF08451.11 CDW53754.1 - 0.15 12.4 3.4 0.29 11.4 3.1 1.7 1 1 0 1 1 1 0 Adenosine/AMP deaminase N-terminal zf-C2H2 PF00096.26 CDW53755.1 - 3.5e-22 77.5 51.3 4.4e-06 26.9 3.4 7.0 6 1 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW53755.1 - 3.4e-21 74.7 48.4 7.9e-07 29.2 2.1 6.7 6 1 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW53755.1 - 2.3e-15 55.9 48.0 0.00014 22.4 2.5 6.7 6 1 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CDW53755.1 - 0.00018 21.7 19.9 0.008 16.5 9.3 3.1 1 1 0 2 2 2 2 C2H2-type zinc ribbon zf-Di19 PF05605.12 CDW53755.1 - 0.001 19.3 30.1 0.59 10.5 0.5 4.7 2 1 2 4 4 3 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 CDW53755.1 - 0.0031 17.2 2.2 0.0031 17.2 2.2 7.2 9 2 0 9 9 8 1 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 CDW53755.1 - 0.019 14.7 25.0 0.62 9.9 1.3 4.5 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 CDW53755.1 - 0.02 15.2 0.4 0.02 15.2 0.4 5.0 5 0 0 5 5 4 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 CDW53755.1 - 0.038 13.9 0.4 0.038 13.9 0.4 4.9 6 0 0 6 6 5 0 zinc-finger of a C2HC-type zf-C2H2_2 PF12756.7 CDW53755.1 - 0.07 13.5 28.0 1.3 9.3 0.5 4.4 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 CDW53755.1 - 0.093 12.8 40.6 0.094 12.7 1.1 5.8 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_9 PF16293.5 CDW53755.1 - 0.17 11.7 0.1 0.17 11.7 0.1 4.8 3 1 2 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2HE PF16278.5 CDW53755.1 - 3.1 8.3 30.6 0.13 12.8 1.0 5.0 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-AN1 PF01428.16 CDW53755.1 - 4 7.7 31.9 2.9 8.2 7.9 5.2 4 1 1 5 5 5 0 AN1-like Zinc finger C2 PF00168.30 CDW53757.1 - 4.1e-55 184.4 0.1 3.8e-29 101.0 0.1 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 CDW53757.1 - 1.7e-05 24.4 0.0 0.079 12.5 0.0 2.4 2 0 0 2 2 2 2 CEP76 C2 domain Adeno_E3_CR2 PF02439.15 CDW53757.1 - 0.019 14.7 3.2 0.039 13.7 3.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF2207 PF09972.9 CDW53757.1 - 0.1 11.3 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Lustrin_cystein PF14625.6 CDW53758.1 - 1.7e-106 348.4 395.5 9.4e-09 35.5 8.5 26.5 26 0 0 26 26 26 26 Lustrin, cysteine-rich repeated domain DUF1970 PF09301.10 CDW53758.1 - 1.7 8.9 6.6 29 5.0 0.2 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1970) AMP-binding PF00501.28 CDW53759.1 - 2.5e-51 174.6 0.2 3.4e-33 114.9 0.1 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 CDW53759.1 - 1.9e-10 41.6 0.0 4.3e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF727 PF05303.12 CDW53760.1 - 9.7e-35 118.8 0.0 1.3e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Collagen PF01391.18 CDW53761.1 - 2.4e-24 84.8 104.4 1.7e-07 30.9 34.9 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW53761.1 - 2.4e-16 59.5 0.2 3.1e-16 59.2 0.2 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain PAP2 PF01569.21 CDW53763.1 - 7e-23 80.9 4.4 7e-23 80.9 4.4 1.6 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 CDW53763.1 - 0.0014 18.4 6.3 0.0017 18.1 3.4 2.3 2 1 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 CDW53763.1 - 0.003 18.1 1.5 0.003 18.1 1.5 2.6 3 1 0 3 3 3 1 PAP2 superfamily C-terminal LrgB PF04172.16 CDW53763.1 - 0.42 10.1 3.3 0.27 10.7 1.3 1.6 2 0 0 2 2 2 0 LrgB-like family DUF2628 PF10947.8 CDW53763.1 - 0.49 10.8 4.9 0.23 11.9 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) 4HBT_3 PF13622.6 CDW53764.1 - 3.7e-56 191.2 0.0 4.5e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CDW53764.1 - 1.1e-28 99.7 0.0 1.9e-22 79.5 0.0 3.2 2 1 0 2 2 2 2 Acyl-CoA thioesterase DEAD PF00270.29 CDW53765.1 - 8.5e-28 97.3 0.5 1.3e-27 96.7 0.5 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW53765.1 - 5.9e-18 65.2 0.1 1.6e-17 63.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW53765.1 - 0.0007 19.6 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDW53765.1 - 0.0039 16.9 0.0 0.0089 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 CDW53765.1 - 0.031 14.1 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_19 PF13245.6 CDW53765.1 - 0.031 14.6 0.1 1.2 9.5 0.1 2.5 2 1 0 2 2 2 0 AAA domain Alpha_L_fucos PF01120.17 CDW53766.1 - 1.7e-124 415.9 9.4 2e-124 415.6 9.4 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 CDW53766.1 - 1.3e-16 60.9 0.9 2.7e-16 59.9 0.9 1.6 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain GHL6 PF14871.6 CDW53766.1 - 0.00029 21.0 0.0 0.0011 19.1 0.0 2.0 1 1 1 2 2 2 1 Hypothetical glycosyl hydrolase 6 Phage_Treg PF04761.12 CDW53766.1 - 0.02 15.0 0.2 0.28 11.3 0.0 2.6 1 1 1 2 2 2 0 Lactococcus bacteriophage putative transcription regulator DHC PF09626.10 CDW53766.1 - 0.021 15.7 0.0 8.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Dihaem cytochrome c Kinesin PF00225.23 CDW53767.1 - 2.4e-104 348.9 0.0 3.1e-104 348.5 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDW53767.1 - 1.4e-52 177.6 0.0 2.4e-52 176.8 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding HTH_57 PF18679.1 CDW53767.1 - 0.086 13.2 0.1 0.19 12.1 0.1 1.5 1 0 0 1 1 1 0 ThcOx helix turn helix domain EF-hand_1 PF00036.32 CDW53768.1 - 2.4e-29 98.7 4.0 1.4e-07 30.5 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 CDW53768.1 - 8.2e-25 85.2 6.0 2.9e-06 26.5 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDW53768.1 - 1.7e-24 86.1 0.4 5e-13 49.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDW53768.1 - 5e-23 80.7 8.1 1.1e-09 37.9 0.2 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CDW53768.1 - 1.8e-22 77.3 1.3 1.4e-06 27.8 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain SPARC_Ca_bdg PF10591.9 CDW53768.1 - 7.7e-08 32.6 0.0 0.0092 16.3 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDW53768.1 - 1.3e-06 28.3 0.3 0.00056 19.8 0.1 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CDW53768.1 - 6.7e-05 23.1 0.0 0.035 14.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain Dockerin_1 PF00404.18 CDW53768.1 - 0.00012 22.2 5.3 0.0097 16.1 0.4 3.4 2 2 0 2 2 2 2 Dockerin type I domain Caleosin PF05042.13 CDW53768.1 - 0.0002 21.4 0.0 0.76 9.7 0.0 2.4 2 0 0 2 2 2 2 Caleosin related protein EF-hand_14 PF17959.1 CDW53768.1 - 0.0034 17.7 0.3 0.97 9.8 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain SurA_N_3 PF13624.6 CDW53768.1 - 0.011 15.5 0.2 0.24 11.2 0.0 2.1 2 1 1 3 3 3 0 SurA N-terminal domain VCBS PF13517.6 CDW53768.1 - 0.018 15.6 2.8 0.76 10.4 0.3 3.0 2 2 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TIL PF01826.17 CDW53770.1 - 2.2e-16 59.8 52.6 3.7e-09 36.7 16.8 3.3 3 0 0 3 3 3 2 Trypsin Inhibitor like cysteine rich domain DUF1633 PF07794.11 CDW53770.1 - 0.31 9.2 0.3 0.4 8.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) Ephrin PF00812.17 CDW53771.1 - 2.4e-30 105.3 0.1 3.2e-30 104.9 0.1 1.2 1 0 0 1 1 1 1 Ephrin Ion_trans_2 PF07885.16 CDW53772.1 - 7e-21 74.0 14.3 1.2e-15 57.3 8.4 2.3 2 0 0 2 2 2 2 Ion channel DUF2157 PF09925.9 CDW53772.1 - 0.068 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) FlgT_N PF16548.5 CDW53772.1 - 2.7 8.6 7.6 0.65 10.6 3.1 2.4 2 0 0 2 2 2 0 Flagellar assembly protein T, N-terminal domain WD40 PF00400.32 CDW53774.1 - 1.5e-26 92.1 1.3 2.9e-05 24.7 0.0 6.0 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53774.1 - 3.8e-14 52.8 0.0 0.004 17.4 0.0 5.6 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 CDW53774.1 - 0.00029 19.3 0.0 0.036 12.4 0.0 2.2 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Ge1_WD40 PF16529.5 CDW53774.1 - 0.013 14.5 0.0 1.1 8.1 0.0 2.9 1 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDW53774.1 - 0.095 12.0 0.3 0.32 10.3 0.1 1.9 2 0 0 2 2 2 0 WD40-like domain RhoGAP PF00620.27 CDW53775.1 - 8.7e-39 132.8 0.1 2.3e-36 124.9 0.0 2.4 2 0 0 2 2 2 2 RhoGAP domain RhoGAP-FF1 PF16512.5 CDW53776.1 - 2.9e-19 69.5 1.8 5.1e-19 68.7 0.4 2.3 2 0 0 2 2 2 1 p190-A and -B Rho GAPs FF domain Ras PF00071.22 CDW53776.1 - 9e-05 22.1 0.0 1.4 8.5 0.0 3.5 3 0 0 3 3 3 2 Ras family FF PF01846.19 CDW53776.1 - 0.043 14.0 0.4 16 5.8 0.0 4.0 4 0 0 4 4 4 0 FF domain ubiquitin PF00240.23 CDW53777.1 - 2.9e-07 30.1 0.0 5e-06 26.2 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin family zf-AN1 PF01428.16 CDW53777.1 - 0.00035 20.7 11.6 0.00095 19.3 11.6 1.8 1 0 0 1 1 1 1 AN1-like Zinc finger Rad60-SLD PF11976.8 CDW53777.1 - 0.053 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Lactamase_B PF00753.27 CDW53778.1 - 6.4e-18 65.5 3.1 1.2e-17 64.6 2.8 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDW53778.1 - 6.4e-05 22.6 0.3 9.7e-05 22.0 0.3 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CDW53778.1 - 0.061 12.8 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain BAR_3_WASP_bdg PF10456.9 CDW53779.1 - 2.2e-66 223.7 3.7 3.8e-66 222.9 3.7 1.4 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 CDW53779.1 - 2.3e-20 72.6 0.1 5.8e-20 71.4 0.1 1.7 1 0 0 1 1 1 1 PX domain SH3_9 PF14604.6 CDW53779.1 - 3.7e-13 49.1 0.1 6.8e-13 48.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW53779.1 - 1.4e-09 37.4 0.1 3.3e-09 36.2 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CDW53779.1 - 8.1e-08 31.8 0.0 1.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Ank_2 PF12796.7 CDW53780.1 - 3.5e-43 146.1 21.0 6.9e-08 33.0 1.6 9.6 2 2 10 12 12 12 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW53780.1 - 6e-31 106.4 22.0 1.4e-10 41.5 0.5 11.4 8 2 6 15 15 15 6 Ankyrin repeats (many copies) Patatin PF01734.22 CDW53780.1 - 3.7e-30 105.6 3.2 2.2e-15 57.4 0.1 4.0 2 2 0 2 2 2 2 Patatin-like phospholipase Ank PF00023.30 CDW53780.1 - 2.3e-29 100.5 33.3 0.0012 19.2 1.4 14.3 14 1 0 14 14 14 6 Ankyrin repeat Ank_5 PF13857.6 CDW53780.1 - 3e-25 87.9 18.9 1.7e-07 31.4 0.8 9.3 6 3 3 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW53780.1 - 4e-25 85.1 25.6 0.0032 17.8 0.0 14.6 17 1 0 17 17 17 7 Ankyrin repeat DUF4535 PF15054.6 CDW53780.1 - 3.5e-06 26.7 0.2 1.8e-05 24.3 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4535) Ish1 PF10281.9 CDW53780.1 - 0.083 13.2 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein DUF3718 PF12514.8 CDW53780.1 - 0.11 12.7 0.0 3.3 7.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3718) SRP54 PF00448.22 CDW53781.1 - 6.8e-77 257.5 0.1 1.1e-76 256.8 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CDW53781.1 - 1.2e-29 102.9 1.6 1.2e-29 102.9 1.6 3.4 2 1 2 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 CDW53781.1 - 1.2e-18 67.1 1.0 4.1e-18 65.4 1.0 2.0 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 CDW53781.1 - 8.2e-06 25.5 0.9 3.3e-05 23.6 0.9 1.9 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDW53781.1 - 1.6e-05 25.1 0.0 3.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CDW53781.1 - 3.4e-05 23.9 0.0 0.00012 22.1 0.0 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 CDW53781.1 - 0.00025 21.5 0.0 0.00074 19.9 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 CDW53781.1 - 0.00068 19.1 0.4 1.5 8.3 0.0 2.6 1 1 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA PF00004.29 CDW53781.1 - 0.0008 19.8 0.6 0.011 16.2 0.1 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 CDW53781.1 - 0.0016 18.9 0.3 0.0061 17.0 0.0 2.2 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.12 CDW53781.1 - 0.0028 17.0 0.0 0.0053 16.1 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin ResIII PF04851.15 CDW53781.1 - 0.0038 17.3 0.3 0.01 15.8 0.3 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2209 PF09974.9 CDW53781.1 - 0.0056 17.0 0.3 0.014 15.7 0.3 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) GTP_EFTU PF00009.27 CDW53781.1 - 0.0058 16.2 0.2 0.02 14.4 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW53781.1 - 0.0059 16.7 0.1 0.046 13.8 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_31 PF13614.6 CDW53781.1 - 0.008 16.1 0.0 0.022 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CDW53781.1 - 0.009 15.0 0.0 0.048 12.6 0.0 2.1 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 CDW53781.1 - 0.0093 15.9 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 CDW53781.1 - 0.026 14.3 0.0 0.062 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 CDW53781.1 - 0.027 14.4 0.5 0.087 12.7 0.0 2.1 2 1 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B CLP1_P PF16575.5 CDW53781.1 - 0.031 14.1 0.4 4.2 7.1 0.0 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_28 PF13521.6 CDW53781.1 - 0.035 14.3 0.0 0.063 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 CDW53781.1 - 0.042 13.1 0.0 0.11 11.8 0.0 1.7 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_22 PF13401.6 CDW53781.1 - 0.047 14.0 1.8 0.24 11.7 0.2 2.9 2 1 1 3 3 3 0 AAA domain PduV-EutP PF10662.9 CDW53781.1 - 0.058 13.1 0.7 0.53 10.0 0.2 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 CDW53781.1 - 0.087 13.2 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDW53781.1 - 0.11 12.5 0.0 0.35 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW53781.1 - 0.15 12.6 0.3 0.41 11.2 0.3 1.9 1 1 0 1 1 1 0 AAA domain ArsA_ATPase PF02374.15 CDW53781.1 - 2.8 7.0 9.4 0.14 11.4 0.1 3.3 3 2 1 4 4 4 0 Anion-transporting ATPase FancD2 PF14631.6 CDW53782.1 - 2.4e-57 194.3 25.5 4.3e-40 137.2 6.6 4.4 2 2 2 4 4 4 4 Fanconi anaemia protein FancD2 nuclease Mst1_SARAH PF11629.8 CDW53782.1 - 0.0084 16.2 0.5 1.8 8.7 0.0 3.4 3 0 0 3 3 3 1 C terminal SARAH domain of Mst1 PAN_1 PF00024.26 CDW53783.1 - 3.3e-15 55.8 11.0 8.2e-13 48.1 5.2 2.5 2 0 0 2 2 2 2 PAN domain Gar1 PF04410.14 CDW53784.1 - 3.9e-33 114.4 0.0 5.3e-33 114.0 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region PRC PF05239.16 CDW53784.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 PRC-barrel domain RNase_T PF00929.24 CDW53785.1 - 2.3e-07 31.5 0.0 5.7e-07 30.2 0.0 1.7 2 0 0 2 2 2 1 Exonuclease Ets PF00178.22 CDW53786.1 - 2.8e-32 111.0 0.4 4.4e-32 110.4 0.4 1.3 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 CDW53786.1 - 0.0046 16.9 0.0 0.016 15.1 0.0 1.8 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Nckap1 PF09735.9 CDW53787.1 - 0 1459.3 22.1 0 1459.1 22.1 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein T6SS_VipA PF05591.12 CDW53787.1 - 0.014 15.2 0.2 0.038 13.8 0.2 1.7 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 Baculo_p24 PF05073.12 CDW53787.1 - 0.024 14.4 0.3 0.091 12.5 0.0 2.2 2 0 0 2 2 2 0 Baculovirus P24 capsid protein RPN1_RPN2_N PF17781.1 CDW53788.1 - 3.3e-97 325.6 4.9 4.1e-93 312.2 1.1 2.3 1 1 1 2 2 2 2 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CDW53788.1 - 1.6e-17 63.3 0.1 3.2e-17 62.3 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CDW53788.1 - 2.3e-15 56.1 9.9 0.0097 16.3 0.5 8.0 8 0 0 8 8 8 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CDW53788.1 - 5.3e-05 23.5 0.1 0.014 15.7 0.0 4.1 3 2 1 4 4 4 2 HEAT repeats zf-CCHC PF00098.23 CDW53789.1 - 0.00015 21.6 42.5 0.00071 19.5 4.4 5.7 5 0 0 5 5 5 4 Zinc knuckle zf-CCHC_3 PF13917.6 CDW53789.1 - 0.016 15.2 1.2 0.016 15.2 1.2 5.1 2 1 3 5 5 5 0 Zinc knuckle zf-CCHC_2 PF13696.6 CDW53789.1 - 0.032 14.0 0.1 0.032 14.0 0.1 6.4 6 1 1 7 7 7 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDW53789.1 - 1.6 8.5 44.2 1.5 8.6 2.0 5.3 3 1 2 5 5 5 0 Zinc knuckle PDZ PF00595.24 CDW53790.1 - 1.3e-35 121.6 7.4 5.1e-11 42.8 0.1 4.9 5 0 0 5 5 4 4 PDZ domain PDZ_6 PF17820.1 CDW53790.1 - 8.1e-21 73.6 3.2 1.6e-07 31.0 0.0 4.8 5 0 0 5 5 5 3 PDZ domain Guanylate_kin PF00625.21 CDW53790.1 - 4.9e-12 45.9 0.1 4.9e-12 45.9 0.1 2.6 2 0 0 2 2 2 1 Guanylate kinase PDZ_2 PF13180.6 CDW53790.1 - 9.6e-12 45.1 5.7 0.0016 18.7 0.2 5.1 4 1 1 5 5 5 3 PDZ domain SH3_2 PF07653.17 CDW53790.1 - 0.0012 18.5 0.1 0.0042 16.7 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 CDW53790.1 - 0.049 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 SH3 domain NAR2 PF16974.5 CDW53790.1 - 0.14 11.5 2.5 0.43 10.0 0.1 2.7 3 0 0 3 3 3 0 High-affinity nitrate transporter accessory GAS PF13851.6 CDW53790.1 - 0.19 11.0 63.8 0.38 10.1 14.3 6.0 2 2 2 4 4 4 0 Growth-arrest specific micro-tubule binding WEMBL PF05701.11 CDW53790.1 - 0.21 10.2 52.2 1.6 7.3 5.8 2.9 2 1 0 2 2 2 0 Weak chloroplast movement under blue light SUIM_assoc PF16619.5 CDW53790.1 - 1 9.5 14.9 0.076 13.1 8.2 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF4407 PF14362.6 CDW53790.1 - 4.6 6.5 31.7 0.41 10.0 8.6 3.4 2 1 1 4 4 4 0 Domain of unknown function (DUF4407) Cystatin PF00031.21 CDW53791.1 - 1.1e-13 51.3 0.3 1.4e-13 50.9 0.3 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 CDW53791.1 - 8.7e-06 26.0 0.7 0.00027 21.2 0.1 2.1 1 1 0 2 2 2 2 Aspartic acid proteinase inhibitor Cystatin PF00031.21 CDW53792.1 - 1.7e-14 53.9 1.9 2.6e-14 53.3 1.4 1.5 1 1 1 2 2 2 2 Cystatin domain SQAPI PF16845.5 CDW53792.1 - 0.00039 20.7 0.2 0.0013 19.0 0.0 1.8 2 0 0 2 2 2 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 CDW53793.1 - 4.2e-27 94.3 7.1 5.2e-15 55.5 1.8 2.4 2 1 0 2 2 2 2 Cystatin domain SQAPI PF16845.5 CDW53793.1 - 5.3e-10 39.5 0.9 0.00057 20.2 0.1 2.5 2 0 0 2 2 2 2 Aspartic acid proteinase inhibitor YjbF PF11102.8 CDW53793.1 - 0.00068 19.5 0.5 0.32 10.7 0.1 2.2 2 0 0 2 2 2 2 Group 4 capsule polysaccharide lipoprotein gfcB, YjbF Calsarcin PF05556.11 CDW53793.1 - 0.015 14.9 1.8 0.39 10.2 0.2 2.1 1 1 1 2 2 2 0 Calcineurin-binding protein (Calsarcin) FANCI_S4 PF14678.6 CDW53793.1 - 0.021 13.9 1.2 1.5 7.9 0.1 2.1 2 0 0 2 2 2 0 FANCI solenoid 4 Izumo-Ig PF16706.5 CDW53793.1 - 0.099 12.7 0.8 2.6 8.2 0.2 2.3 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain LRR_8 PF13855.6 CDW53794.1 - 8e-54 179.3 61.4 2e-13 49.9 2.3 7.7 3 1 5 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 CDW53794.1 - 3.7e-26 90.8 43.6 7.2e-05 23.1 1.8 8.7 1 1 9 10 10 10 10 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW53794.1 - 2.9e-19 69.3 0.3 2.8e-08 33.8 0.3 3.4 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CDW53794.1 - 2.7e-14 51.5 39.7 0.19 12.4 0.3 12.9 12 1 1 13 13 13 6 Leucine Rich Repeat LRR_9 PF14580.6 CDW53794.1 - 1.1e-11 44.5 15.0 0.00027 20.5 1.1 4.2 1 1 4 5 5 5 5 Leucine-rich repeat LRR_6 PF13516.6 CDW53794.1 - 9.8e-06 25.2 34.7 3.7 7.8 0.2 11.3 12 0 0 12 12 12 3 Leucine Rich repeat Aft1_OSA PF11785.8 CDW53794.1 - 0.076 13.5 0.0 0.27 11.7 0.0 1.9 1 0 0 1 1 1 0 Aft1 osmotic stress response (OSM) domain LRR_8 PF13855.6 CDW53795.1 - 1.7e-53 178.3 22.4 3e-14 52.5 1.8 7.0 3 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 CDW53795.1 - 1.4e-20 73.0 27.3 2.1e-05 24.8 1.5 8.0 5 3 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW53795.1 - 1.2e-16 60.8 0.0 2.8e-08 33.8 0.0 3.5 2 1 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 CDW53795.1 - 6.6e-12 45.3 7.0 0.0091 15.5 0.1 4.7 1 1 4 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.33 CDW53795.1 - 6.2e-10 38.2 21.1 0.53 11.0 0.0 10.5 11 1 1 12 12 12 3 Leucine Rich Repeat DUF5305 PF17231.2 CDW53795.1 - 0.17 11.3 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) LRR_6 PF13516.6 CDW53795.1 - 0.39 10.9 24.4 6.8 7.0 0.2 8.5 9 0 0 9 9 9 0 Leucine Rich repeat ADH_N PF08240.12 CDW53796.1 - 3.1e-24 84.9 0.9 7.8e-24 83.7 0.9 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CDW53796.1 - 2.9e-22 79.1 0.1 8.4e-22 77.5 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CDW53796.1 - 0.0023 17.3 0.1 0.0037 16.6 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CDW53796.1 - 0.04 15.0 0.0 0.076 14.1 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase TrkA_N PF02254.18 CDW53796.1 - 0.08 13.2 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain HSNSD PF12062.8 CDW53797.1 - 2.5e-165 551.0 3.2 5.3e-165 549.9 3.2 1.6 1 1 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 CDW53797.1 - 4.5e-28 98.5 0.1 2.3e-27 96.2 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDW53797.1 - 7.3e-05 23.3 1.4 0.021 15.2 0.1 3.5 2 1 1 3 3 3 2 Sulfotransferase family Med31 PF05669.12 CDW53799.1 - 0.15 12.0 1.4 0.18 11.8 0.1 1.7 1 1 1 2 2 2 0 SOH1 Ribosomal_S17_N PF16205.5 CDW53800.1 - 1.1e-33 115.4 0.4 1.1e-33 115.4 0.4 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CDW53800.1 - 3.4e-25 87.9 3.5 5.1e-25 87.4 3.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 PRF PF06875.11 CDW53800.1 - 0.04 13.4 0.1 0.062 12.7 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF DUF1679 PF07914.11 CDW53801.1 - 1.5e-17 63.6 0.2 2.4e-16 59.6 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 CDW53801.1 - 1.6e-12 47.4 0.0 3e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 CDW53801.1 - 0.027 14.4 0.0 0.086 12.8 0.0 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF1679 PF07914.11 CDW53802.1 - 2.5e-34 118.9 0.0 4.3e-32 111.5 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 CDW53802.1 - 2.2e-23 83.0 0.1 2.3e-21 76.4 0.1 2.2 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 CDW53802.1 - 2.3e-12 47.4 0.0 3.5e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 CDW53802.1 - 0.013 14.7 0.1 0.057 12.6 0.1 2.0 1 1 0 1 1 1 0 Fructosamine kinase SBDS_C PF09377.10 CDW53802.1 - 0.016 15.2 0.0 0.057 13.4 0.0 1.7 1 1 0 1 1 1 0 SBDS protein C-terminal domain Kdo PF06293.14 CDW53802.1 - 0.036 13.4 0.0 2.3 7.5 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M16 PF00675.20 CDW53803.1 - 5.9e-53 178.9 0.1 1.2e-52 177.9 0.1 1.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDW53803.1 - 2.3e-31 109.2 0.0 5.3e-30 104.8 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain DUF2561 PF10812.8 CDW53805.1 - 0.27 11.3 1.3 0.43 10.6 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) PDZ_5 PF17817.1 CDW53806.1 - 6.2e-28 96.9 0.4 1.7e-27 95.5 0.4 1.7 1 0 0 1 1 1 1 PDZ domain SAM_2 PF07647.17 CDW53806.1 - 1.4e-11 44.3 0.1 2.7e-10 40.2 0.0 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 CDW53806.1 - 1.4e-11 44.6 0.3 2.9e-11 43.6 0.3 1.5 1 0 0 1 1 1 1 PDZ domain SAM_1 PF00536.30 CDW53806.1 - 3.9e-10 40.0 0.0 7.2e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 CDW53806.1 - 0.0007 19.4 0.0 0.0056 16.5 0.0 2.5 2 0 0 2 2 2 1 PDZ domain Poty_PP PF08440.10 CDW53806.1 - 0.45 9.6 3.2 0.84 8.7 3.2 1.4 1 0 0 1 1 1 0 Potyviridae polyprotein TACC_C PF05010.14 CDW53806.1 - 0.77 9.5 23.6 0.024 14.4 17.0 1.8 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal MOZ_SAS PF01853.18 CDW53807.1 - 2.2e-70 236.0 0.0 3.1e-70 235.5 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CDW53807.1 - 2.6e-20 71.8 1.9 6e-20 70.6 1.9 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 CDW53807.1 - 2.4e-09 36.9 0.2 6.4e-09 35.6 0.2 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CDW53807.1 - 0.0049 17.3 0.0 0.012 16.0 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-C2H2_4 PF13894.6 CDW53807.1 - 0.076 13.9 1.6 0.28 12.1 1.6 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger Tna_leader PF08053.11 CDW53807.1 - 0.12 12.4 0.0 0.54 10.3 0.0 2.1 2 0 0 2 2 2 0 Tryptophanase operon leader peptide Stathmin PF00836.19 CDW53808.1 - 1.2e-20 73.9 7.2 1.5e-20 73.5 7.2 1.1 1 0 0 1 1 1 1 Stathmin family MG2 PF01835.19 CDW53809.1 - 3.5e-14 53.0 0.0 9.6e-14 51.6 0.0 1.7 2 0 0 2 2 2 1 MG2 domain MG3 PF17791.1 CDW53809.1 - 6.6e-06 26.3 0.9 1.5e-05 25.2 0.9 1.7 1 0 0 1 1 1 1 Macroglobulin domain MG3 MG1 PF17790.1 CDW53809.1 - 0.023 15.1 0.2 0.058 13.8 0.2 1.8 1 1 0 1 1 1 0 Macroglobulin domain MG1 HCV_NS4a PF01006.20 CDW53809.1 - 0.032 14.0 0.1 0.13 12.0 0.0 2.0 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a TED_complement PF07678.14 CDW53810.1 - 7.8e-76 255.1 0.5 1.1e-59 202.1 0.3 2.4 1 1 1 2 2 2 2 A-macroglobulin TED domain A2M PF00207.22 CDW53810.1 - 6.2e-23 80.5 0.0 1.4e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 CDW53810.1 - 7.2e-22 78.2 0.2 8.5e-21 74.8 0.0 2.8 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain A2M_recep PF07677.14 CDW53810.1 - 1e-20 74.2 0.4 1e-20 74.2 0.4 2.3 2 0 0 2 2 2 1 A-macroglobulin receptor binding domain MG3 PF17791.1 CDW53810.1 - 0.00035 20.8 0.0 0.0014 18.9 0.0 2.1 2 0 0 2 2 2 1 Macroglobulin domain MG3 MG4 PF17789.1 CDW53810.1 - 0.053 13.7 0.1 19 5.5 0.0 3.2 2 0 0 2 2 2 0 Macroglobulin domain MG4 SGT1 PF07093.11 CDW53811.1 - 1.1 7.6 10.2 2.2 6.6 10.1 1.5 2 0 0 2 2 2 0 SGT1 protein PPL5 PF18168.1 CDW53811.1 - 1.3 8.3 7.8 2.1 7.6 7.8 1.4 1 0 0 1 1 1 0 Prim-pol family 5 NARP1 PF12569.8 CDW53811.1 - 2.5 6.9 12.3 3.6 6.4 12.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Sec62 PF03839.16 CDW53811.1 - 9.4 5.7 9.6 15 5.0 9.6 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 Fumble PF03630.14 CDW53813.1 - 2.3e-91 306.4 0.1 2.7e-71 240.5 0.0 2.0 2 0 0 2 2 2 2 Fumble Hydant_A_N PF05378.13 CDW53813.1 - 0.033 13.9 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region Ge1_WD40 PF16529.5 CDW53814.1 - 8e-47 159.8 1.5 1.6e-46 158.8 1.5 1.5 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DASH_Duo1 PF08651.10 CDW53814.1 - 1.2 9.0 3.3 6.7 6.6 0.4 3.3 3 1 1 4 4 4 0 DASH complex subunit Duo1 UFD1 PF03152.14 CDW53815.1 - 1.5e-34 118.9 0.0 2.6e-34 118.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 RNA_pol_Rpb4 PF03874.16 CDW53816.1 - 5.9e-17 62.1 0.8 8.2e-17 61.7 0.8 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Med10 PF09748.9 CDW53816.1 - 0.011 15.6 0.4 0.016 15.2 0.3 1.3 1 1 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex DUF2757 PF10955.8 CDW53816.1 - 0.057 13.7 0.1 0.08 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) Ldh_2 PF02615.14 CDW53817.1 - 1.5e-104 349.8 0.3 1.7e-104 349.6 0.3 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase CC2D2AN-C2 PF15625.6 CDW53819.1 - 2.3e-33 115.4 0.0 4.7e-33 114.4 0.0 1.5 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.30 CDW53819.1 - 0.09 13.1 0.0 0.34 11.2 0.0 2.1 2 0 0 2 2 2 0 C2 domain Tcf25 PF04910.14 CDW53820.1 - 6.9e-58 196.4 0.5 9.4e-58 195.9 0.5 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 Ank_2 PF12796.7 CDW53821.1 - 8.4e-25 87.2 3.1 2e-15 57.1 0.4 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW53821.1 - 4.8e-20 71.7 0.6 1.3e-11 44.8 0.1 4.3 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW53821.1 - 5.2e-19 68.1 2.9 3.1e-09 36.9 0.1 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW53821.1 - 1.2e-17 62.2 2.5 0.00012 22.2 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 CDW53821.1 - 1e-15 57.4 5.8 0.00015 22.0 0.1 5.3 5 0 0 5 5 5 3 Ankyrin repeat KN_motif PF12075.8 CDW53821.1 - 2.3e-07 30.5 0.1 6.4e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 KN motif Pkinase_Tyr PF07714.17 CDW53822.1 - 2.5e-82 276.0 0.0 3.6e-82 275.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW53822.1 - 2.3e-38 132.1 0.0 4.8e-23 81.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain APH PF01636.23 CDW53822.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family SWIM PF04434.17 CDW53823.1 - 0.0019 17.8 0.7 0.0065 16.1 0.7 2.0 1 0 0 1 1 1 1 SWIM zinc finger Cut8 PF08559.10 CDW53823.1 - 0.0025 17.4 0.4 0.058 13.0 0.0 2.4 2 0 0 2 2 2 1 Cut8, nuclear proteasome tether protein Cmc1 PF08583.10 CDW53824.1 - 2.1e-11 43.7 1.2 2.1e-11 43.7 1.2 1.8 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 CDW53824.1 - 0.013 15.2 1.0 0.025 14.3 1.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Ribosomal_L27A PF00828.19 CDW53825.1 - 2e-07 31.7 0.0 2.4e-06 28.2 0.0 2.3 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A CBF_beta PF02312.17 CDW53826.1 - 1.3e-28 99.8 0.0 2.6e-28 98.8 0.0 1.4 1 1 0 1 1 1 1 Core binding factor beta subunit YTH PF04146.15 CDW53827.1 - 0.0081 16.1 0.0 0.58 10.1 0.0 2.1 1 1 1 2 2 2 2 YT521-B-like domain FH2 PF02181.23 CDW53828.1 - 1.7e-78 264.3 0.9 2.5e-78 263.8 0.9 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 CDW53828.1 - 0.0001 22.0 1.3 0.00051 19.7 0.0 2.6 3 0 0 3 3 3 1 Diaphanous FH3 Domain Formin_GBD_N PF18382.1 CDW53828.1 - 0.00033 21.1 0.0 0.0015 19.0 0.0 2.2 1 0 0 1 1 1 1 Formin N-terminal GTPase-binding domain DUF3361 PF11841.8 CDW53828.1 - 0.029 14.3 0.0 0.075 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3361) Drf_GBD PF06371.13 CDW53828.1 - 2.1 7.9 6.4 0.12 11.9 0.2 2.0 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain ECH_1 PF00378.20 CDW53829.1 - 6.7e-87 290.9 0.6 7.8e-87 290.7 0.6 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDW53829.1 - 1.9e-39 136.1 1.8 2e-35 122.9 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CDW53829.1 - 0.00014 21.8 0.1 0.076 13.0 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 SDH_sah PF01972.16 CDW53829.1 - 0.024 13.6 0.2 0.46 9.4 0.0 2.0 2 0 0 2 2 2 0 Serine dehydrogenase proteinase ApoLp-III PF07464.11 CDW53829.1 - 0.069 13.2 1.1 0.15 12.1 1.1 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) UPF0160 PF03690.13 CDW53829.1 - 0.084 12.5 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) zf-H2C2_2 PF13465.6 CDW53830.1 - 2.7e-20 71.8 10.7 2.7e-08 33.9 0.2 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 CDW53830.1 - 5.8e-18 64.3 17.0 1.4e-06 28.4 0.6 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW53830.1 - 3.4e-11 43.0 14.2 0.00098 19.8 2.3 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW53830.1 - 0.00025 21.0 6.4 0.053 13.5 0.7 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CDW53830.1 - 0.00029 20.7 10.1 0.85 9.6 0.3 3.8 3 0 0 3 3 3 3 zinc-finger of a C2HC-type zf-met PF12874.7 CDW53830.1 - 0.00036 20.8 5.2 0.66 10.5 0.5 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW53830.1 - 0.00044 20.5 1.0 15 6.0 0.1 3.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding Zf_RING PF16744.5 CDW53830.1 - 0.079 13.1 4.0 0.7 10.0 0.1 2.8 1 1 2 3 3 3 0 KIAA1045 RING finger zf-BED PF02892.15 CDW53830.1 - 0.11 12.5 6.8 0.24 11.4 2.6 2.7 1 1 1 2 2 2 0 BED zinc finger C1_2 PF03107.16 CDW53830.1 - 0.2 12.0 5.3 15 6.0 0.1 3.6 2 1 1 3 3 3 0 C1 domain HNH PF01844.23 CDW53830.1 - 1.9 8.7 5.7 9.1 6.5 0.1 3.2 3 0 0 3 3 3 0 HNH endonuclease RNA_pol_Rpb1_5 PF04998.17 CDW53832.1 - 5.2e-85 285.1 0.1 1e-84 284.2 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 CDW53832.1 - 2.1e-76 257.2 1.0 3.2e-76 256.6 1.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 CDW53832.1 - 4.9e-72 241.6 0.0 1e-71 240.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CDW53832.1 - 1.4e-38 132.3 0.0 3.8e-38 130.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CDW53832.1 - 1.2e-26 92.8 0.0 3.8e-26 91.1 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Glyco_hydro_47 PF01532.20 CDW53833.1 - 3.4e-104 349.3 0.0 4.4e-104 348.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 GnHR_trans PF12369.8 CDW53833.1 - 0.17 12.7 0.2 0.46 11.3 0.0 1.8 2 0 0 2 2 2 0 Gonadotropin hormone receptor transmembrane region LRRFIP PF09738.9 CDW53834.1 - 1.2e-58 199.0 28.7 1.2e-58 199.0 28.7 2.1 2 0 0 2 2 2 1 LRRFIP family DUF5037 PF16440.5 CDW53834.1 - 0.025 14.1 0.1 0.045 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5037) Helveticin_J PF17312.2 CDW53834.1 - 0.04 13.0 0.3 0.6 9.2 0.1 2.1 2 0 0 2 2 2 0 Bacteriocin helveticin-J ATG16 PF08614.11 CDW53834.1 - 1.6 8.9 48.1 0.045 14.0 14.1 3.4 1 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 CDW53834.1 - 1.9 8.5 24.5 0.066 13.3 3.8 4.2 3 1 2 5 5 5 0 Protein of unknown function (DUF1664) DNA_RNApol_7kD PF03604.13 CDW53835.1 - 4.1e-15 55.2 8.8 5.2e-15 54.8 8.8 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 CDW53835.1 - 0.0076 16.3 0.4 0.0077 16.2 0.4 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_13 PF09855.9 CDW53835.1 - 0.0091 16.1 2.9 0.0093 16.1 0.1 2.0 1 1 1 2 2 2 1 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) UPF0547 PF10571.9 CDW53835.1 - 0.091 12.9 0.0 0.091 12.9 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Rubredoxin_2 PF18073.1 CDW53835.1 - 0.53 10.1 5.5 2.1 8.1 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain RNA_POL_M_15KD PF02150.16 CDW53835.1 - 2.4 8.1 6.8 10 6.1 1.0 2.3 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit Dynein_light PF01221.18 CDW53836.1 - 5.3e-41 138.8 1.5 5.8e-41 138.7 1.5 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ectatomin PF06457.11 CDW53836.1 - 0.081 12.9 0.6 0.081 12.9 0.6 1.9 2 0 0 2 2 2 0 Ectatomin SNF2_N PF00176.23 CDW53837.1 - 1.6e-54 184.9 0.1 3.1e-54 184.0 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3535 PF12054.8 CDW53837.1 - 1.1e-32 113.9 2.9 1.1e-32 113.9 2.9 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF3535) Helicase_C PF00271.31 CDW53837.1 - 2.2e-17 63.4 0.0 7.1e-17 61.8 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 CDW53837.1 - 5.2e-05 23.2 17.2 2.5 8.6 0.0 8.1 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.6 CDW53837.1 - 0.0075 16.7 7.1 36 5.0 0.1 6.6 7 1 0 7 7 7 0 HEAT-like repeat RRM_1 PF00076.22 CDW53838.1 - 2.8e-33 113.6 0.0 4.8e-18 64.7 0.0 2.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CDW53838.1 - 4.8e-08 33.0 0.0 0.0071 16.4 0.0 2.3 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM_2 PF14605.6 CDW53838.1 - 0.0018 18.2 0.0 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 CDW53838.1 - 0.014 15.5 0.0 0.063 13.4 0.0 2.1 3 0 0 3 3 3 0 RNA recognition motif DUF1645 PF07816.11 CDW53838.1 - 0.041 14.5 7.4 0.07 13.7 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) RRM_occluded PF16842.5 CDW53838.1 - 0.18 11.7 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Pkinase PF00069.25 CDW53839.1 - 2.8e-67 226.9 0.0 3.3e-67 226.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53839.1 - 2.1e-34 119.0 0.0 3.1e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW53839.1 - 0.00037 19.9 0.2 0.25 10.6 0.1 2.2 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.22 CDW53839.1 - 0.0066 16.1 0.1 0.015 14.9 0.1 1.5 1 1 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 CDW53839.1 - 0.014 14.3 0.1 0.038 12.9 0.1 1.7 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CDW53839.1 - 0.075 12.9 0.0 0.16 11.8 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family PDZ PF00595.24 CDW53840.1 - 5e-14 52.4 0.0 1e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW53840.1 - 7.5e-07 28.9 0.0 2.3e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 CDW53840.1 - 1.7e-06 28.5 0.1 0.0006 20.3 0.1 2.6 2 0 0 2 2 2 2 PH domain PH_17 PF18012.1 CDW53840.1 - 0.01 15.5 0.0 0.052 13.3 0.0 2.1 1 1 0 1 1 1 0 PH domain Bt_P21 PF05560.11 CDW53840.1 - 0.068 12.8 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein Tricorn_PDZ PF14685.6 CDW53840.1 - 0.085 12.8 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 Tricorn protease PDZ domain VWA PF00092.28 CDW53841.1 - 1e-38 133.3 0.2 2.1e-38 132.3 0.2 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain EGF_3 PF12947.7 CDW53841.1 - 1.7e-37 127.3 316.1 4.4e-06 26.8 5.0 27.0 29 0 0 29 29 29 17 EGF domain EGF_CA PF07645.15 CDW53841.1 - 8.9e-35 118.6 364.3 8.9e-07 29.0 4.2 28.5 29 1 0 29 29 29 18 Calcium-binding EGF domain EGF PF00008.27 CDW53841.1 - 3.5e-26 91.2 330.5 9.5e-06 25.8 2.2 28.1 29 0 0 29 29 29 17 EGF-like domain hEGF PF12661.7 CDW53841.1 - 7.5e-24 83.5 295.2 5.9e-05 23.5 0.6 29.1 29 0 0 29 29 29 18 Human growth factor-like EGF SEA PF01390.20 CDW53841.1 - 2.8e-13 49.9 1.2 0.0085 16.2 0.1 4.0 4 0 0 4 4 4 3 SEA domain VWA_2 PF13519.6 CDW53841.1 - 3.6e-13 50.1 0.0 7.8e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain cEGF PF12662.7 CDW53841.1 - 3.1e-05 23.8 219.6 0.006 16.5 0.2 27.4 28 1 0 28 28 28 14 Complement Clr-like EGF-like FXa_inhibition PF14670.6 CDW53841.1 - 0.017 15.4 0.5 0.017 15.4 0.5 29.0 27 4 3 30 30 30 0 Coagulation Factor Xa inhibitory site PUF PF00806.19 CDW53843.1 - 2.8e-11 42.4 0.0 5.2e-05 22.7 0.0 3.2 3 0 0 3 3 3 2 Pumilio-family RNA binding repeat IFT46_B_C PF12317.8 CDW53844.1 - 1e-34 120.2 0.2 1.3e-34 119.8 0.2 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal Glyco_hydro_39 PF01229.17 CDW53844.1 - 0.047 12.3 0.0 0.067 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 RRM_1 PF00076.22 CDW53845.1 - 1.6e-22 79.1 2.9 2.3e-09 36.9 0.0 4.2 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SDF PF00375.18 CDW53847.1 - 1.3e-123 412.9 19.1 1.6e-123 412.6 19.1 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family BNIP3 PF06553.12 CDW53847.1 - 0.00033 20.4 0.0 0.00069 19.4 0.0 1.5 1 0 0 1 1 1 1 BNIP3 MARVEL PF01284.23 CDW53847.1 - 0.28 11.2 6.4 0.47 10.5 0.2 3.0 2 1 0 2 2 2 0 Membrane-associating domain GrpE PF01025.19 CDW53848.1 - 1.9e-31 108.9 0.0 2.2e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 GrpE Ribosomal_S7 PF00177.21 CDW53849.1 - 9.2e-17 61.1 0.2 1.9e-13 50.3 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S7p/S5e HypA PF01155.19 CDW53849.1 - 0.039 14.0 0.1 0.06 13.4 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RRM_1 PF00076.22 CDW53850.1 - 1.4e-17 63.3 0.0 2.3e-16 59.4 0.0 2.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 CDW53850.1 - 6.3e-15 55.4 0.2 3.9e-13 49.7 0.0 2.6 3 0 0 3 3 3 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_7 PF16367.5 CDW53850.1 - 0.09 12.9 0.0 0.23 11.6 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif Nop PF01798.18 CDW53851.1 - 1.3e-75 253.9 0.0 1.7e-75 253.4 0.0 1.1 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CDW53851.1 - 5.6e-19 68.3 0.3 1.1e-18 67.3 0.3 1.5 1 0 0 1 1 1 1 NOP5NT (NUC127) domain PAN_1 PF00024.26 CDW53852.1 - 1.1e-32 111.8 45.3 6.3e-10 38.9 2.8 6.5 6 0 0 6 6 6 6 PAN domain DUF2812 PF11193.8 CDW53852.1 - 2.2 8.5 4.1 36 4.6 0.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2812) Kelch_5 PF13854.6 CDW53853.1 - 2.2e-68 225.4 11.8 6.6e-05 22.8 0.0 12.5 12 0 0 12 12 12 12 Kelch motif Kelch_3 PF13415.6 CDW53853.1 - 1.7e-54 181.2 14.2 7.6e-06 26.1 0.1 14.2 14 0 0 14 14 14 10 Galactose oxidase, central domain Kelch_4 PF13418.6 CDW53853.1 - 2.7e-46 155.3 7.0 3.4e-06 27.0 0.1 12.4 11 1 1 12 12 12 10 Galactose oxidase, central domain Kelch_6 PF13964.6 CDW53853.1 - 7.4e-40 134.0 11.2 0.00044 20.4 0.0 12.2 11 2 0 11 11 11 9 Kelch motif Kelch_1 PF01344.25 CDW53853.1 - 3.4e-36 122.6 10.1 5.4e-05 22.7 0.0 11.0 11 0 0 11 11 11 9 Kelch motif Kelch_2 PF07646.15 CDW53853.1 - 1.6e-26 91.2 24.0 0.0023 17.8 0.0 12.5 13 1 0 13 13 13 8 Kelch motif fn3 PF00041.21 CDW53853.1 - 7e-18 64.8 0.6 0.0011 19.3 0.0 6.8 7 0 0 7 7 7 4 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 CDW53853.1 - 0.032 14.8 0.0 9.4 6.9 0.0 3.0 3 0 0 3 3 3 0 Purple acid Phosphatase, N-terminal domain RHH_4 PF13467.6 CDW53853.1 - 0.18 11.7 0.3 0.39 10.6 0.0 1.7 2 0 0 2 2 2 0 Ribbon-helix-helix domain SpaA PF17802.1 CDW53854.1 - 0.0066 16.8 0.0 0.0076 16.5 0.0 1.2 1 0 0 1 1 1 1 Prealbumin-like fold domain EFF-AFF PF14884.6 CDW53855.1 - 1.6e-67 228.0 0.1 2.6e-67 227.3 0.1 1.3 1 1 0 1 1 1 1 Type I membrane glycoproteins cell-cell fusogen RRM_1 PF00076.22 CDW53856.1 - 5.6e-37 125.4 0.0 1.6e-15 56.7 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DND1_DSRM PF14709.7 CDW53856.1 - 6.6e-16 58.3 0.0 1.6e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_7 PF16367.5 CDW53856.1 - 3.8e-05 23.7 0.1 0.063 13.4 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif RRM_5 PF13893.6 CDW53856.1 - 0.069 12.7 0.0 10 5.7 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 CDW53856.1 - 0.087 12.6 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain Beach PF02138.18 CDW53857.1 - 1.7e-122 408.1 0.1 2.8e-122 407.4 0.1 1.3 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.21 CDW53857.1 - 1.7e-16 60.1 14.9 1.7e-16 60.1 14.9 2.6 2 0 0 2 2 2 1 FYVE zinc finger PH_BEACH PF14844.6 CDW53857.1 - 2e-13 50.3 0.0 9.2e-13 48.2 0.0 2.1 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH DUF4704 PF15787.5 CDW53857.1 - 1.2e-08 34.5 4.3 5.5e-08 32.4 0.8 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4704) WD40 PF00400.32 CDW53857.1 - 4.7e-05 24.1 10.0 0.0012 19.6 0.1 5.1 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF4800 PF16057.5 CDW53857.1 - 0.0012 18.2 0.6 0.0034 16.7 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) Laminin_G_3 PF13385.6 CDW53857.1 - 0.032 14.4 0.0 0.083 13.0 0.0 1.6 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily IBR PF01485.21 CDW53857.1 - 0.079 13.2 6.1 0.29 11.4 6.1 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Vac14_Fig4_bd PF11916.8 CDW53857.1 - 0.32 10.6 7.8 1.6 8.4 1.4 3.6 2 1 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding RrnaAD PF00398.20 CDW53858.1 - 6.7e-52 176.2 0.0 8.6e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 CDW53858.1 - 9.5e-06 26.2 0.0 2.6e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDW53858.1 - 0.00074 19.1 0.0 0.0018 17.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CDW53858.1 - 0.0018 18.9 0.0 0.0036 17.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW53858.1 - 0.013 15.5 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CDW53858.1 - 0.058 13.2 0.0 0.067 13.0 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CDW53858.1 - 0.062 13.0 0.0 0.099 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 CDW53858.1 - 0.11 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ank_2 PF12796.7 CDW53859.1 - 1.5e-145 474.1 31.8 3.9e-17 62.6 1.2 12.2 1 1 10 11 11 11 11 Ankyrin repeats (3 copies) Ank PF00023.30 CDW53859.1 - 2.3e-128 413.6 55.6 6.4e-08 32.7 0.1 24.0 24 0 0 24 24 24 21 Ankyrin repeat Ank_4 PF13637.6 CDW53859.1 - 9.2e-125 405.6 25.2 1.9e-13 50.6 0.2 16.1 5 4 12 18 18 18 18 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW53859.1 - 1.3e-116 379.2 40.1 9.3e-13 48.1 0.1 19.1 3 3 17 21 21 21 20 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW53859.1 - 1.6e-116 366.0 32.8 1.7e-07 31.0 0.1 24.0 24 0 0 24 24 24 18 Ankyrin repeat UPA_2 PF17809.1 CDW53859.1 - 7.6e-45 151.9 0.0 1.7e-44 150.8 0.0 1.6 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 CDW53859.1 - 2.7e-36 123.8 0.5 4e-28 97.6 0.0 2.8 2 0 0 2 2 2 2 ZU5 domain PK_C PF02887.16 CDW53859.1 - 0.00094 19.4 0.0 3.9 7.7 0.0 4.5 3 1 1 4 4 4 1 Pyruvate kinase, alpha/beta domain IlvN PF07991.12 CDW53859.1 - 0.019 14.6 0.8 2.6 7.6 0.0 4.0 3 2 2 5 5 5 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain YfmQ PF10787.9 CDW53859.1 - 0.026 14.3 0.0 42 3.9 0.0 5.2 5 1 1 6 6 6 0 Uncharacterised protein from bacillus cereus group Gpi1 PF05024.15 CDW53860.1 - 2.3e-50 171.3 6.4 4e-50 170.5 6.4 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Mito_carr PF00153.27 CDW53860.1 - 2.1e-44 149.4 3.6 1.8e-15 56.6 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Thioredoxin_8 PF13905.6 CDW53861.1 - 1.8e-48 162.8 0.0 6.7e-29 100.1 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 CDW53861.1 - 1.7e-18 66.7 0.1 1.3e-08 34.8 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 CDW53861.1 - 4.3e-16 59.0 0.1 1.8e-08 34.2 0.0 2.4 1 1 1 2 2 2 2 Redoxin Thioredoxin PF00085.20 CDW53861.1 - 2e-13 50.2 0.7 2.2e-06 27.6 0.0 3.2 2 1 0 3 3 3 3 Thioredoxin Thioredoxin_2 PF13098.6 CDW53861.1 - 1e-10 42.0 0.1 7.8e-07 29.5 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin-like domain TraF PF13728.6 CDW53861.1 - 4.3e-08 33.3 0.1 0.0028 17.5 0.0 2.4 3 0 0 3 3 3 2 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 CDW53861.1 - 2.3e-06 27.4 0.0 0.0088 15.8 0.0 2.8 3 0 0 3 3 3 2 Thioredoxin SCO1-SenC PF02630.14 CDW53861.1 - 1.5e-05 24.9 0.0 0.19 11.6 0.0 2.2 2 0 0 2 2 2 2 SCO1/SenC Glutaredoxin PF00462.24 CDW53861.1 - 9.3e-05 22.6 0.6 0.28 11.4 0.0 2.8 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin_7 PF13899.6 CDW53861.1 - 0.0001 22.4 0.1 0.032 14.4 0.1 3.2 2 1 1 3 3 3 1 Thioredoxin-like DUF953 PF06110.11 CDW53861.1 - 0.011 15.3 0.2 1.2 8.8 0.1 2.8 3 1 0 3 3 3 0 Eukaryotic protein of unknown function (DUF953) NADH_4Fe-4S PF10589.9 CDW53861.1 - 0.09 12.9 0.0 6.6 6.9 0.0 2.4 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PDEase_I PF00233.19 CDW53862.1 - 1.8e-76 257.0 9.3 1.8e-76 257.0 9.3 1.7 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.12 CDW53862.1 - 3.5e-11 42.8 0.4 7.1e-11 41.8 0.4 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal Baculo_PEP_C PF04513.12 CDW53863.1 - 0.0017 18.4 0.1 0.0019 18.2 0.1 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.6 CDW53863.1 - 0.0025 17.2 2.7 0.0031 16.9 2.7 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding YkyA PF10368.9 CDW53863.1 - 0.0042 16.8 3.7 0.0054 16.4 3.7 1.1 1 0 0 1 1 1 1 Putative cell-wall binding lipoprotein Apolipoprotein PF01442.18 CDW53863.1 - 0.0066 16.3 1.8 0.0085 16.0 1.8 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain FPP PF05911.11 CDW53863.1 - 0.01 14.1 2.3 0.011 13.9 2.3 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil SpoIISA_toxin PF14171.6 CDW53863.1 - 0.014 15.2 1.0 0.017 14.8 1.0 1.1 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Translin PF01997.16 CDW53863.1 - 0.015 15.3 0.3 0.017 15.1 0.3 1.1 1 0 0 1 1 1 0 Translin family Nsp1_C PF05064.13 CDW53863.1 - 0.019 14.8 4.4 0.039 13.7 0.8 2.2 1 1 1 2 2 2 0 Nsp1-like C-terminal region ABC_tran_CTD PF16326.5 CDW53863.1 - 0.022 15.0 3.9 0.033 14.4 1.7 2.1 1 1 1 2 2 2 0 ABC transporter C-terminal domain FapA PF03961.13 CDW53863.1 - 0.022 13.4 0.6 0.024 13.3 0.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A NPV_P10 PF05531.12 CDW53863.1 - 0.028 14.9 1.6 0.066 13.7 1.4 1.7 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein SOG2 PF10428.9 CDW53863.1 - 0.03 13.5 0.4 0.035 13.3 0.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein V_ATPase_I PF01496.19 CDW53863.1 - 0.033 12.1 1.4 0.034 12.1 1.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HSBP1 PF06825.12 CDW53863.1 - 0.035 13.9 0.5 0.14 12.0 0.3 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Fzo_mitofusin PF04799.13 CDW53863.1 - 0.036 13.6 0.7 0.05 13.2 0.5 1.4 1 1 0 1 1 1 0 fzo-like conserved region BshC PF10079.9 CDW53863.1 - 0.038 12.7 1.0 0.043 12.6 1.0 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Exonuc_VII_L PF02601.15 CDW53863.1 - 0.054 13.1 0.5 0.055 13.0 0.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5446 PF17522.2 CDW53863.1 - 0.064 13.4 1.2 0.11 12.6 0.6 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5446) CdvA PF18822.1 CDW53863.1 - 0.068 13.0 3.0 0.14 11.9 2.7 1.8 1 1 1 2 2 2 0 CdvA-like coiled-coil domain TruD PF01142.18 CDW53863.1 - 0.082 11.7 0.4 0.094 11.5 0.4 1.1 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) DUF2779 PF11074.8 CDW53863.1 - 0.11 13.0 1.2 0.35 11.3 0.5 1.9 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) PRP1_N PF06424.12 CDW53863.1 - 0.16 12.4 0.9 0.23 11.8 0.9 1.3 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal CorA PF01544.18 CDW53863.1 - 0.16 11.2 2.2 0.21 10.9 2.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Spc24 PF08286.11 CDW53863.1 - 0.5 10.6 4.4 13 6.1 4.4 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 PDZ_6 PF17820.1 CDW53864.1 - 0.026 14.4 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 CDW53864.1 - 0.13 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 PDZ domain 3HCDH_N PF02737.18 CDW53865.1 - 6e-54 182.7 0.5 8.4e-54 182.2 0.5 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CDW53865.1 - 9.9e-35 119.1 0.0 2.6e-34 117.7 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DUF1188 PF06690.11 CDW53865.1 - 0.029 13.9 0.0 0.056 13.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1188) Pyr_redox_2 PF07992.14 CDW53865.1 - 0.069 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF4603 PF15376.6 CDW53865.1 - 0.16 9.4 0.5 0.19 9.1 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Sacchrp_dh_NADP PF03435.18 CDW53865.1 - 0.49 10.7 2.5 1.1 9.6 0.6 2.3 3 1 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain DKCLD PF08068.12 CDW53866.1 - 3.5e-28 97.4 0.2 1.4e-27 95.5 0.3 1.9 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 CDW53866.1 - 1.3e-22 80.8 0.3 1.3e-19 71.0 0.3 3.1 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 CDW53866.1 - 3.2e-19 68.7 0.6 6.4e-19 67.7 0.6 1.5 1 0 0 1 1 1 1 PUA domain TruB_C_2 PF16198.5 CDW53866.1 - 2.3e-18 66.1 0.1 4.1e-18 65.3 0.1 1.4 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain UPF0113 PF03657.13 CDW53866.1 - 0.037 14.3 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 UPF0113 PUA domain SH2 PF00017.24 CDW53867.1 - 3e-10 40.0 0.0 4.9e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 SH2 domain ODR4-like PF14778.6 CDW53868.1 - 8e-31 107.3 0.0 1e-30 107.0 0.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 4-like Phosphodiest PF01663.22 CDW53869.1 - 1.3e-74 252.0 0.9 1.6e-74 251.7 0.9 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CDW53869.1 - 0.03 13.7 0.1 0.049 13.0 0.1 1.2 1 0 0 1 1 1 0 Sulfatase cNMP_binding PF00027.29 CDW53871.1 - 1.6e-14 53.7 0.0 2.7e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain WD40 PF00400.32 CDW53872.1 - 8.4e-14 51.8 0.9 2.6e-05 24.9 0.1 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53872.1 - 3.6e-08 33.6 0.6 5.4e-05 23.4 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW53872.1 - 0.0027 17.6 0.0 1.9 8.3 0.0 2.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A ATP_bind_1 PF03029.17 CDW53873.1 - 1.9e-61 207.9 0.1 2.1e-61 207.8 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 CDW53873.1 - 8.8e-06 25.6 0.0 1.3e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 CDW53873.1 - 0.00023 20.4 0.0 0.00051 19.3 0.0 1.5 1 1 0 1 1 1 1 Anion-transporting ATPase AAA_22 PF13401.6 CDW53873.1 - 0.0007 19.9 0.0 0.003 17.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_31 PF13614.6 CDW53873.1 - 0.0013 18.7 0.0 0.0039 17.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain CLP1_P PF16575.5 CDW53873.1 - 0.0036 17.1 0.0 0.028 14.2 0.0 2.0 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CbiA PF01656.23 CDW53873.1 - 0.0056 16.7 0.0 0.0065 16.5 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 CDW53873.1 - 0.0091 15.7 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CDW53873.1 - 0.01 14.8 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 CDW53873.1 - 0.013 15.0 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_28 PF13521.6 CDW53873.1 - 0.022 15.0 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW53873.1 - 0.022 15.3 0.4 0.045 14.3 0.4 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDW53873.1 - 0.025 14.3 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.6 CDW53873.1 - 0.026 14.9 0.3 0.065 13.7 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CDW53873.1 - 0.035 14.5 0.3 0.054 13.9 0.3 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CDW53873.1 - 0.037 14.1 0.0 0.51 10.4 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.6 CDW53873.1 - 0.053 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CDW53873.1 - 0.055 13.2 0.0 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 CDW53873.1 - 0.059 13.8 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 CDW53873.1 - 0.061 13.3 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SRP54 PF00448.22 CDW53873.1 - 0.063 12.9 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 CDW53873.1 - 0.084 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 CDW53873.1 - 0.086 13.0 0.1 0.1 12.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CDW53873.1 - 0.13 12.2 0.3 1.1 9.2 0.0 2.3 2 1 0 2 2 2 0 NTPase AAA_16 PF13191.6 CDW53873.1 - 0.14 12.6 0.0 0.19 12.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain DAGK_prokar PF01219.19 CDW53873.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic diacylglycerol kinase Rad17 PF03215.15 CDW53873.1 - 1.5 8.7 4.5 14 5.5 0.3 2.8 1 1 0 2 2 2 0 Rad17 P-loop domain PCRF PF03462.18 CDW53874.1 - 5.5e-44 150.4 0.2 2.9e-43 148.0 0.0 2.0 2 1 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CDW53874.1 - 1.2e-33 115.5 3.2 1.7e-33 115.0 3.2 1.2 1 0 0 1 1 1 1 RF-1 domain MIR PF02815.19 CDW53874.1 - 0.023 14.5 0.1 0.033 14.0 0.1 1.2 1 0 0 1 1 1 0 MIR domain RRM_1 PF00076.22 CDW53875.1 - 4.2e-23 80.9 1.3 1.5e-13 50.3 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CDW53875.1 - 3e-06 27.2 0.2 0.62 10.1 0.0 3.9 4 0 0 4 4 4 3 RNA binding motif Nup35_RRM_2 PF14605.6 CDW53875.1 - 5.2e-05 23.2 0.3 0.046 13.7 0.0 3.3 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif SPOC PF07744.13 CDW53875.1 - 0.0066 16.4 0.0 0.016 15.2 0.0 1.6 1 1 0 1 1 1 1 SPOC domain RRM_occluded PF16842.5 CDW53875.1 - 0.015 15.2 0.0 6.4 6.7 0.0 2.8 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_7 PF16367.5 CDW53875.1 - 0.086 13.0 0.4 6 7.1 0.0 3.1 4 0 0 4 4 4 0 RNA recognition motif zf-RanBP PF00641.18 CDW53876.1 - 0.0092 15.3 2.2 0.02 14.2 2.2 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF1283 PF06932.11 CDW53876.1 - 0.23 11.7 6.1 0.52 10.5 6.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) Jak1_Phl PF17887.1 CDW53876.1 - 6.9 6.6 8.6 37 4.3 6.8 2.1 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Ssl1 PF04056.14 CDW53877.1 - 0.0058 16.5 0.2 0.0087 15.9 0.2 1.2 1 0 0 1 1 1 1 Ssl1-like LMBR1 PF04791.16 CDW53877.1 - 0.22 10.4 0.6 0.28 10.1 0.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Colipase PF01114.18 CDW53877.1 - 0.24 11.1 11.1 0.49 10.1 1.3 2.6 2 0 0 2 2 2 0 Colipase, N-terminal domain FapA PF03961.13 CDW53877.1 - 0.97 8.0 5.2 1.3 7.6 5.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 CDW53877.1 - 2 7.9 7.8 2.7 7.5 7.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit YBD PF17725.1 CDW53879.1 - 1.5e-85 286.3 0.0 1.9e-85 285.9 0.0 1.1 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 CDW53879.1 - 3e-27 94.5 0.1 6e-27 93.5 0.1 1.5 1 0 0 1 1 1 1 TEA/ATTS domain CDI PF02234.19 CDW53880.1 - 1.6e-05 25.0 0.1 3.4e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor Neur_chan_memb PF02932.16 CDW53881.1 - 0.0021 18.2 9.4 0.0026 17.9 9.4 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Calc_CGRP_IAPP PF00214.19 CDW53881.1 - 0.025 14.9 7.3 0.27 11.6 7.3 2.0 1 1 0 1 1 1 0 Calcitonin / CGRP / IAPP family SpoIIIAH PF12685.7 CDW53881.1 - 0.052 13.4 10.9 0.08 12.8 10.9 1.4 1 1 0 1 1 1 0 SpoIIIAH-like protein BT1 PF03092.16 CDW53881.1 - 0.13 10.5 4.8 0.14 10.4 4.8 1.2 1 1 0 1 1 1 0 BT1 family Connexin PF00029.19 CDW53881.1 - 0.17 11.6 18.2 1 9.1 18.1 1.9 1 1 0 1 1 1 0 Connexin HCO3_cotransp PF00955.21 CDW53881.1 - 0.19 10.5 0.6 0.2 10.5 0.6 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF3742 PF12553.8 CDW53881.1 - 0.24 11.5 0.0 0.24 11.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3742) SID-1_RNA_chan PF13965.6 CDW53881.1 - 0.24 9.7 6.9 0.3 9.4 6.8 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 GPR15L PF15854.5 CDW53881.1 - 0.25 11.6 3.7 0.22 11.8 0.3 2.2 2 1 0 2 2 2 0 G-protein coupled receptor ligand 15 TMEM132D_C PF15706.5 CDW53881.1 - 0.28 11.0 6.1 0.7 9.7 4.2 2.5 1 1 1 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term O-antigen_lig PF13425.6 CDW53881.1 - 0.29 9.9 3.0 0.33 9.7 3.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF1772 PF08592.11 CDW53881.1 - 0.32 11.3 0.6 0.63 10.4 0.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) SLC12 PF03522.15 CDW53881.1 - 1.2 8.1 15.8 1.3 8.0 15.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 GRP PF07172.11 CDW53881.1 - 1.2 9.8 10.7 6.8 7.5 8.8 2.5 1 1 1 2 2 1 0 Glycine rich protein family DUF1682 PF07946.14 CDW53881.1 - 1.2 8.2 21.4 2 7.5 21.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Chordopox_A13L PF05961.11 CDW53881.1 - 1.3 9.3 4.4 9.6 6.5 4.4 2.4 1 1 0 1 1 1 0 Chordopoxvirus A13L protein TRAP_alpha PF03896.16 CDW53881.1 - 1.4 8.1 8.8 0.29 10.3 5.1 1.6 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DDHD PF02862.17 CDW53881.1 - 1.4 9.0 12.3 2.1 8.4 12.3 1.2 1 0 0 1 1 1 0 DDHD domain DUF2500 PF10694.9 CDW53881.1 - 2 9.0 9.9 0.098 13.2 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2500) Ctr PF04145.15 CDW53881.1 - 2.8 8.6 8.9 5.5 7.6 8.9 1.6 1 1 0 1 1 1 0 Ctr copper transporter family DUF4569 PF15133.6 CDW53881.1 - 3.5 7.3 11.9 4.8 6.8 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) CRA PF06589.11 CDW53881.1 - 3.7 7.7 21.2 0.34 11.0 15.1 1.9 1 1 1 2 2 2 0 Circumsporozoite-related antigen (CRA) CLN3 PF02487.17 CDW53881.1 - 4.9 6.1 8.9 5.9 5.8 8.8 1.4 1 1 0 1 1 1 0 CLN3 protein DUF4834 PF16118.5 CDW53881.1 - 5.1 8.1 17.4 83 4.2 17.4 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) tRNA_anti-like PF12869.7 CDW53881.1 - 5.7 6.5 7.4 3.7 7.1 3.8 2.4 2 1 0 2 2 2 0 tRNA_anti-like Ndc1_Nup PF09531.10 CDW53881.1 - 5.8 5.5 8.5 6.6 5.3 8.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Raftlin PF15250.6 CDW53881.1 - 6.8 5.3 16.7 8.1 5.1 16.7 1.1 1 0 0 1 1 1 0 Raftlin V_ATPase_I PF01496.19 CDW53881.1 - 8.5 4.1 15.9 1.2 7.0 12.1 1.4 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Ribonuc_red_lgC PF02867.15 CDW53882.1 - 1.7e-186 620.8 0.0 2.1e-186 620.5 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CDW53882.1 - 5.7e-24 83.9 0.0 1.5e-23 82.6 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CDW53882.1 - 2.7e-13 50.3 0.0 7.9e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 ATP cone domain Tmemb_170 PF10190.9 CDW53883.1 - 5.1e-26 91.1 11.4 5.7e-26 91.0 11.4 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF2530 PF10745.9 CDW53883.1 - 2.2 8.6 7.6 0.25 11.6 2.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Gly_acyl_tr_C PF08444.10 CDW53884.1 - 0.0045 17.2 0.1 0.0088 16.3 0.1 1.5 1 0 0 1 1 1 1 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Glyco_hydro_20 PF00728.22 CDW53885.1 - 1.6e-74 251.5 0.1 2.2e-74 251.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 CDW53885.1 - 2.6e-09 37.9 0.0 6e-09 36.7 0.0 1.7 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 CDW53885.1 - 0.23 12.3 0.0 0.39 11.5 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 Trehalase PF01204.18 CDW53886.1 - 5.2e-138 461.1 7.0 5.9e-138 460.9 7.0 1.0 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.16 CDW53886.1 - 4.6e-05 22.4 0.3 4.6e-05 22.4 0.3 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain GDE_C PF06202.14 CDW53886.1 - 7.3e-05 21.9 1.4 8.4e-05 21.7 0.2 1.6 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase eIF-3_zeta PF05091.12 CDW53887.1 - 3.7e-142 475.0 0.1 1.6e-141 472.9 0.1 2.0 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 CDW53887.1 - 9e-06 25.3 0.0 3.2e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 NMDA receptor-regulated gene protein 2 C-terminus PDZ PF00595.24 CDW53888.1 - 2.5e-15 56.6 0.0 3e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW53888.1 - 6.7e-10 38.7 0.0 1.2e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW53888.1 - 1.6e-07 31.5 0.0 1.8e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 PDZ domain TB2_DP1_HVA22 PF03134.19 CDW53889.1 - 9.6e-27 92.7 7.4 1.4e-26 92.2 7.4 1.2 1 0 0 1 1 1 1 TB2/DP1, HVA22 family NAD_binding_9 PF13454.6 CDW53889.1 - 0.052 13.5 0.0 0.084 12.9 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding HA2 PF04408.23 CDW53890.1 - 1.1e-22 80.3 0.0 1.1e-22 80.3 0.0 3.9 4 0 0 4 4 4 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDW53890.1 - 1.4e-15 57.4 0.0 3.4e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDW53890.1 - 6.6e-12 45.8 0.0 1.7e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW53890.1 - 0.00013 21.8 4.9 0.00043 20.1 0.5 3.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDW53890.1 - 0.00025 21.3 0.0 0.00098 19.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDW53890.1 - 0.001 18.8 1.1 0.0013 18.5 0.0 1.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDW53890.1 - 0.034 13.2 0.0 0.082 11.9 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_19 PF13245.6 CDW53890.1 - 0.045 14.1 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDW53890.1 - 0.054 12.8 0.1 0.054 12.8 0.1 1.8 2 0 0 2 2 2 0 KaiC Flavi_DEAD PF07652.14 CDW53890.1 - 0.14 12.2 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain cobW PF02492.19 CDW53890.1 - 0.15 11.6 0.2 0.48 10.0 0.2 1.9 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 CDW53890.1 - 0.18 12.3 16.3 0.68 10.4 0.0 3.6 3 1 0 3 3 2 0 AAA domain SRP54 PF00448.22 CDW53890.1 - 0.31 10.6 0.0 0.31 10.6 0.0 1.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF5127 PF17168.4 CDW53890.1 - 1.3 8.8 6.2 9.7 5.9 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5127) F-box PF00646.33 CDW53891.1 - 7.3e-07 28.9 0.5 2.2e-06 27.4 0.5 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CDW53891.1 - 8.8e-05 22.3 2.1 0.00027 20.8 2.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 CDW53891.1 - 0.0037 17.2 0.2 5.4 7.3 0.0 3.5 4 0 0 4 4 4 2 Leucine Rich repeat F-box_5 PF18511.1 CDW53891.1 - 0.0067 16.0 0.4 0.015 14.9 0.4 1.5 1 0 0 1 1 1 1 F-box PCI PF01399.27 CDW53892.1 - 9.4e-12 45.4 0.1 8.4e-11 42.3 0.0 2.4 2 0 0 2 2 2 1 PCI domain Atg8 PF02991.16 CDW53893.1 - 1.5e-48 163.3 0.1 1.7e-48 163.1 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CDW53893.1 - 8.2e-08 32.5 0.0 9.9e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Homeodomain PF00046.29 CDW53894.1 - 4.6e-22 77.6 5.1 7.9e-22 76.9 5.1 1.4 1 0 0 1 1 1 1 Homeodomain Engrail_1_C_sig PF10525.9 CDW53894.1 - 4.2e-10 38.7 1.0 8.6e-10 37.7 1.0 1.4 1 0 0 1 1 1 1 Engrailed homeobox C-terminal signature domain Homeobox_KN PF05920.11 CDW53894.1 - 0.0041 17.0 0.4 0.01 15.7 0.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain CENP-B_N PF04218.13 CDW53894.1 - 0.08 12.6 0.3 0.17 11.5 0.3 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain DUF2316 PF10078.9 CDW53894.1 - 0.21 11.8 0.3 0.34 11.2 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) Collagen PF01391.18 CDW53895.1 - 6.3e-18 64.3 62.2 3.2e-11 42.8 23.1 3.8 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Rad51 PF08423.11 CDW53896.1 - 2.2e-20 73.0 0.0 2.9e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 CDW53896.1 - 1.5e-09 37.6 0.2 2.6e-09 36.8 0.2 1.4 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 CDW53896.1 - 2.1e-05 24.2 0.1 3e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW53896.1 - 6.9e-05 23.1 0.0 0.00011 22.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CDW53896.1 - 0.0026 17.7 0.0 0.0037 17.2 0.0 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_10 PF12846.7 CDW53896.1 - 0.015 14.3 0.0 0.022 13.7 0.0 1.3 1 1 0 1 1 1 0 AAA-like domain CobU PF02283.16 CDW53896.1 - 0.051 13.1 0.7 0.69 9.5 0.5 2.1 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Tex_YqgF PF16921.5 CDW53896.1 - 0.052 14.0 0.1 0.12 12.9 0.1 1.6 1 1 0 1 1 1 0 Tex protein YqgF-like domain DBD_HTH PF18430.1 CDW53896.1 - 0.078 12.8 0.4 0.14 11.9 0.4 1.4 1 0 0 1 1 1 0 Putative DNA-binding domain IstB_IS21 PF01695.17 CDW53896.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein DOG1 PF14144.6 CDW53896.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Seed dormancy control Tmpp129 PF10272.9 CDW53897.1 - 1e-89 301.4 3.8 1.2e-89 301.1 3.8 1.0 1 0 0 1 1 1 1 Putative transmembrane protein precursor zf-RING_2 PF13639.6 CDW53897.1 - 0.59 10.5 9.6 2.8 8.3 9.6 2.3 1 1 0 1 1 1 0 Ring finger domain TPR_1 PF00515.28 CDW53898.1 - 2.1e-08 33.6 2.0 0.0019 17.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW53898.1 - 1.6e-06 27.8 0.8 0.048 13.8 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDW53898.1 - 0.016 15.3 0.2 3.4 8.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDW53898.1 - 0.052 13.2 2.6 0.79 9.5 1.0 2.9 2 1 0 2 2 2 0 TPR repeat TPR_12 PF13424.6 CDW53898.1 - 0.079 13.3 0.3 0.17 12.2 0.3 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDW53898.1 - 0.27 11.7 2.8 0.5 10.9 0.6 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat Kelch_4 PF13418.6 CDW53899.1 - 6.4e-18 64.5 6.6 3.4e-08 33.4 0.0 4.5 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_1 PF01344.25 CDW53899.1 - 6.6e-14 51.2 2.4 0.0001 21.8 0.1 4.3 4 1 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 CDW53899.1 - 9.2e-13 48.1 5.1 0.00011 22.4 0.2 4.5 4 1 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 CDW53899.1 - 4e-08 33.2 6.1 6.3e-05 23.1 0.1 3.8 4 1 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 CDW53899.1 - 5.2e-08 32.7 0.3 0.00099 19.0 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 CDW53899.1 - 0.00049 20.0 2.7 0.031 14.3 0.1 3.6 4 0 0 4 4 4 1 Kelch motif Lectin_leg-like PF03388.13 CDW53900.1 - 1.2e-73 247.3 0.0 2e-73 246.5 0.0 1.4 1 0 0 1 1 1 1 Legume-like lectin family S1 PF00575.23 CDW53900.1 - 2.4e-20 72.7 6.1 5.5e-07 29.8 0.0 9.3 11 0 0 11 11 11 4 S1 RNA binding domain Suf PF05843.14 CDW53900.1 - 1.1e-10 42.0 2.3 4.8e-06 26.8 0.2 2.3 2 0 0 2 2 2 2 Suppressor of forked protein (Suf) Bact_lectin PF18483.1 CDW53900.1 - 6.7e-06 26.3 0.0 1.2e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Bacterial lectin TPR_19 PF14559.6 CDW53900.1 - 0.01 16.3 0.0 24 5.5 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDW53900.1 - 0.025 15.4 0.0 18 6.4 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat NRDE-2 PF08424.10 CDW53900.1 - 0.028 13.5 2.8 3.4 6.7 0.0 2.7 1 1 1 2 2 2 0 NRDE-2, necessary for RNA interference TPR_15 PF13429.6 CDW53900.1 - 0.032 13.4 0.8 3.3 6.8 0.0 2.4 1 1 0 2 2 2 0 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 CDW53900.1 - 0.28 11.2 1.2 5.7 7.0 0.1 3.3 3 0 0 3 3 3 0 RNase II-type exonuclease C-terminal S1 domain DUF1115 PF06544.12 CDW53901.1 - 7.6e-12 45.6 2.1 2.2e-11 44.0 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF1115) RWD PF05773.22 CDW53901.1 - 2.1e-06 28.0 0.1 3.7e-06 27.2 0.1 1.4 1 0 0 1 1 1 1 RWD domain SH2 PF00017.24 CDW53902.1 - 1.1e-07 31.8 0.5 0.087 12.9 0.0 3.9 3 0 0 3 3 3 3 SH2 domain EF1G PF00647.19 CDW53902.1 - 0.069 13.2 0.1 1.5 8.9 0.1 2.4 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain MRP-S31 PF15433.6 CDW53903.1 - 1.2e-58 199.2 12.2 1.4e-55 189.2 5.2 2.0 1 1 1 2 2 2 2 Mitochondrial 28S ribosomal protein S31 ubiquitin PF00240.23 CDW53904.1 - 2.6e-06 27.1 0.0 4.4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 CDW53904.1 - 0.063 13.7 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 CDW53904.1 - 0.17 12.4 0.0 0.27 11.8 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDW53904.1 - 0.21 11.7 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like GDPD PF03009.17 CDW53905.1 - 3.6e-27 95.7 0.5 8.6e-27 94.5 0.5 1.6 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family DUF269 PF03270.13 CDW53905.1 - 0.12 12.5 0.1 0.93 9.6 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF269 WD40 PF00400.32 CDW53906.1 - 2.1e-13 50.5 14.4 0.008 17.0 0.0 6.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW53906.1 - 8.3e-05 22.8 0.1 0.064 13.6 0.0 3.9 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF5441 PF17513.2 CDW53906.1 - 0.12 12.0 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5441) PIG-U PF06728.13 CDW53907.1 - 1e-62 212.4 29.3 1.6e-62 211.7 29.3 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U ABC_tran PF00005.27 CDW53908.1 - 3.6e-27 95.6 0.0 1.7e-18 67.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 CDW53908.1 - 4e-15 55.8 29.7 5.6e-08 32.3 8.9 2.5 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 CDW53908.1 - 0.0086 15.9 0.1 3.7 7.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 CDW53908.1 - 0.14 12.7 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain FHA PF00498.26 CDW53909.1 - 6.1e-18 64.9 0.0 1.1e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CDW53909.1 - 0.00055 20.2 0.0 0.044 14.1 0.0 2.3 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF1751 PF08551.10 CDW53910.1 - 2.5e-12 47.2 7.4 2.5e-12 47.2 7.4 1.7 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 CDW53910.1 - 0.28 11.2 11.0 0.24 11.4 9.7 1.5 1 1 0 1 1 1 0 Rhomboid family Porin_3 PF01459.22 CDW53911.1 - 7.6e-62 209.2 0.1 8.8e-62 209.0 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin SNF2_N PF00176.23 CDW53912.1 - 2.6e-52 177.7 2.1 2.9e-49 167.7 0.6 3.1 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW53912.1 - 2.5e-12 47.1 0.0 6.5e-12 45.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW53912.1 - 0.0004 20.4 0.0 0.0014 18.7 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Ig_3 PF13927.6 CDW53913.1 - 6.9e-91 298.9 14.8 8e-11 42.4 0.1 9.7 9 0 0 9 9 9 9 Immunoglobulin domain I-set PF07679.16 CDW53913.1 - 2.5e-81 267.8 6.4 3.7e-10 39.7 0.0 9.3 9 0 0 9 9 9 9 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW53913.1 - 2.6e-67 223.1 9.5 5.7e-08 33.0 0.0 9.8 9 1 0 9 9 9 9 Immunoglobulin domain ig PF00047.25 CDW53913.1 - 5.8e-63 209.1 8.8 5e-08 33.0 0.0 9.6 9 1 0 9 9 9 9 Immunoglobulin domain C2-set_2 PF08205.12 CDW53913.1 - 1e-54 182.6 9.5 5.8e-14 51.9 0.0 8.4 9 0 0 9 9 7 6 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 CDW53913.1 - 1.5e-20 73.3 2.4 0.0051 17.2 0.0 9.5 9 0 0 9 9 9 3 Immunoglobulin C1-set domain V-set PF07686.17 CDW53913.1 - 1.3e-19 70.4 9.7 5.2e-06 26.6 0.0 11.8 9 5 1 10 10 10 3 Immunoglobulin V-set domain fn3 PF00041.21 CDW53913.1 - 1.6e-12 47.6 0.7 1.9e-11 44.2 0.2 2.8 2 0 0 2 2 2 1 Fibronectin type III domain Ig_5 PF16681.5 CDW53913.1 - 2.2e-10 40.8 2.5 0.52 10.7 0.0 8.6 9 1 0 9 9 8 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 CDW53913.1 - 8.6e-06 25.9 4.9 4.4 7.6 0.0 8.6 10 4 1 11 11 9 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 CDW53913.1 - 1.7e-05 24.7 0.4 8.4 6.5 0.0 5.6 6 0 0 6 6 5 1 Izumo-like Immunoglobulin domain Ig_6 PF18452.1 CDW53913.1 - 0.00034 20.1 0.0 1.6 8.3 0.0 3.7 4 0 0 4 4 3 2 Immunoglobulin domain Myc_target_1 PF15179.6 CDW53913.1 - 0.0019 18.1 0.7 0.0048 16.8 0.7 1.6 1 0 0 1 1 1 1 Myc target protein 1 CytoC_RC PF02276.18 CDW53913.1 - 0.0034 16.8 0.1 0.46 9.8 0.0 2.3 2 0 0 2 2 2 1 Photosynthetic reaction centre cytochrome C subunit TMEM154 PF15102.6 CDW53913.1 - 0.0063 16.4 0.6 0.015 15.2 0.2 1.8 1 1 1 2 2 2 1 TMEM154 protein family Pur_ac_phosph_N PF16656.5 CDW53913.1 - 0.043 14.4 0.1 0.52 10.9 0.1 2.9 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Shisa PF13908.6 CDW53913.1 - 0.11 12.8 0.9 0.23 11.7 0.9 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator GAPT PF11770.8 CDW53913.1 - 0.14 12.0 0.2 0.31 10.9 0.2 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) EphA2_TM PF14575.6 CDW53913.1 - 0.16 12.9 0.1 0.61 11.0 0.1 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain SLBP_RNA_bind PF15247.6 CDW53915.1 - 4e-21 74.9 3.6 5.6e-21 74.5 3.6 1.1 1 0 0 1 1 1 1 Histone RNA hairpin-binding protein RNA-binding domain RhoGEF PF00621.20 CDW53916.1 - 1.8e-35 122.9 0.8 1.8e-35 122.9 0.8 1.6 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 CDW53916.1 - 9.1e-07 29.3 0.1 2.4e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 CDW53916.1 - 0.098 12.5 0.1 2.5 7.9 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain Cyclin_N PF00134.23 CDW53917.1 - 1.8e-14 53.5 0.7 4e-14 52.4 0.7 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF5117 PF17148.4 CDW53917.1 - 0.053 13.4 0.2 0.097 12.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5117) DUF371 PF04027.13 CDW53917.1 - 0.36 10.8 3.1 0.44 10.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF371) HIG_1_N PF04588.13 CDW53918.1 - 3.1e-18 65.7 0.2 4.8e-18 65.1 0.2 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF4231 PF14015.6 CDW53918.1 - 0.0049 17.3 0.0 0.0068 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4231) DUF2909 PF11137.8 CDW53918.1 - 0.078 12.9 0.3 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) Herpes_UL69 PF05459.12 CDW53918.1 - 0.096 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus transcriptional regulator family Topoisom_I PF01028.20 CDW53919.1 - 7.9e-100 332.9 7.8 7.9e-100 332.9 7.8 2.3 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 CDW53919.1 - 1.3e-95 318.9 3.1 1.3e-95 318.9 3.1 3.6 3 2 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 CDW53919.1 - 2.1e-31 107.7 0.3 2.1e-31 107.7 0.3 2.4 2 0 0 2 2 2 1 C-terminal topoisomerase domain Peptidase_C1 PF00112.23 CDW53920.1 - 3.2e-53 181.1 5.8 6.2e-53 180.1 5.8 1.5 1 0 0 1 1 1 1 Papain family cysteine protease UFD1 PF03152.14 CDW53921.1 - 2.3e-64 216.0 0.0 3e-64 215.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 CDW53921.1 - 0.011 15.5 0.1 0.045 13.6 0.0 1.9 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 P16-Arc PF04699.14 CDW53922.1 - 2.2e-46 158.0 0.0 3.3e-46 157.4 0.0 1.3 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Ribosomal_L13 PF00572.18 CDW53922.1 - 6.5e-08 32.9 0.1 2.2e-06 27.9 0.1 2.5 1 1 0 1 1 1 1 Ribosomal protein L13 Utp12 PF04003.12 CDW53922.1 - 0.06 13.7 0.0 0.16 12.3 0.0 1.6 2 0 0 2 2 2 0 Dip2/Utp12 Family ORMDL PF04061.14 CDW53923.1 - 3.9e-40 136.8 4.9 9.6e-40 135.5 4.9 1.5 1 1 0 1 1 1 1 ORMDL family Pkinase PF00069.25 CDW53924.1 - 3.7e-28 98.6 0.0 4.6e-28 98.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53924.1 - 9.3e-21 74.3 0.0 1.1e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW53924.1 - 6.4e-07 28.5 0.0 7.2e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDW53924.1 - 0.01 15.2 0.0 0.3 10.3 0.0 2.1 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 CDW53924.1 - 0.012 14.9 0.0 0.029 13.7 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW53924.1 - 0.098 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_8 PF13855.6 CDW53925.1 - 1.8e-91 299.9 110.6 1.7e-15 56.5 9.7 7.8 2 2 9 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 CDW53925.1 - 8.8e-32 108.6 53.3 4.7e-06 26.9 1.4 8.5 5 2 4 10 10 10 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW53925.1 - 5.4e-20 71.6 20.0 1.6e-06 27.7 1.2 5.3 1 1 4 5 5 5 5 Leucine-rich repeat LRR_5 PF13306.6 CDW53925.1 - 1.1e-19 70.7 0.0 3.1e-10 40.1 0.0 2.9 2 2 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CDW53925.1 - 4.8e-14 50.7 37.2 0.028 14.9 0.0 12.8 12 2 0 12 12 12 4 Leucine Rich Repeat LRR_6 PF13516.6 CDW53925.1 - 0.00099 19.0 45.1 0.048 13.7 0.1 10.9 12 0 0 12 12 12 4 Leucine Rich repeat FNIP PF05725.12 CDW53925.1 - 0.17 12.0 3.2 90 3.4 0.1 4.5 4 2 0 4 4 4 0 FNIP Repeat Bromodomain PF00439.25 CDW53926.1 - 1.8e-19 69.6 0.0 4.1e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 Bromodomain MBD PF01429.19 CDW53926.1 - 1.5e-15 56.7 0.0 3.2e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Methyl-CpG binding domain WSD PF15613.6 CDW53926.1 - 1.2e-12 48.1 1.7 1.9e-12 47.5 0.1 2.2 2 0 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD PF00628.29 CDW53926.1 - 2e-11 43.6 24.2 2e-06 27.6 2.9 2.6 2 0 0 2 2 2 2 PHD-finger PHD_2 PF13831.6 CDW53926.1 - 4.4e-06 26.1 0.5 4.4e-06 26.1 0.5 2.7 2 0 0 2 2 2 1 PHD-finger DDT PF02791.17 CDW53926.1 - 0.012 15.9 0.1 0.034 14.4 0.1 1.8 1 0 0 1 1 1 0 DDT domain C1_1 PF00130.22 CDW53926.1 - 0.34 10.8 19.4 1.8 8.5 5.8 2.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 CDW53926.1 - 2.3 7.8 20.8 0.031 13.9 1.7 3.4 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain DehI PF10778.9 CDW53927.1 - 0.0024 18.0 0.2 0.42 10.7 0.0 2.6 2 1 1 3 3 3 2 Halocarboxylic acid dehydrogenase DehI CHDCT2 PF08074.11 CDW53928.1 - 3.6e-84 281.1 0.2 9.8e-84 279.7 0.2 1.8 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain SNF2_N PF00176.23 CDW53928.1 - 1.2e-53 182.1 0.3 4.7e-26 91.3 0.5 2.4 2 0 0 2 2 2 2 SNF2 family N-terminal domain DUF1086 PF06461.11 CDW53928.1 - 4.4e-51 172.3 0.0 1.4e-50 170.8 0.0 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) DUF1087 PF06465.13 CDW53928.1 - 2.2e-26 91.7 12.0 1.4e-25 89.1 9.0 3.0 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.31 CDW53928.1 - 1.4e-21 76.9 0.0 2.9e-21 75.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CHDNT PF08073.12 CDW53928.1 - 1.9e-20 72.5 0.1 4.5e-20 71.4 0.1 1.7 1 0 0 1 1 1 1 CHDNT (NUC034) domain PHD PF00628.29 CDW53928.1 - 3.3e-20 71.7 28.4 1e-10 41.3 7.9 2.5 2 0 0 2 2 2 2 PHD-finger Chromo PF00385.24 CDW53928.1 - 2.3e-13 49.8 10.7 1.6e-10 40.8 1.0 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain HDA2-3 PF11496.8 CDW53928.1 - 4.8e-05 22.7 0.0 0.00014 21.1 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 CDW53928.1 - 5.3e-05 23.3 0.0 0.00021 21.3 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-HC5HC2H PF13771.6 CDW53928.1 - 0.0014 18.9 10.7 0.02 15.1 0.5 2.6 2 0 0 2 2 2 2 PHD-like zinc-binding domain zf-PHD-like PF15446.6 CDW53928.1 - 0.032 13.8 9.5 0.99 9.0 0.8 3.0 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 CDW53928.1 - 0.1 12.1 14.1 1.2 8.7 1.4 2.7 2 0 0 2 2 2 0 PHD-finger zf-RanBP PF00641.18 CDW53928.1 - 1.8 7.9 11.2 4.3 6.8 0.9 2.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zf-HC5HC2H_2 PF13832.6 CDW53928.1 - 4.5 7.5 14.6 4.1 7.6 2.8 2.5 1 1 1 2 2 2 0 PHD-zinc-finger like domain An_peroxidase PF03098.15 CDW53929.1 - 5e-195 649.1 0.0 6.3e-195 648.7 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase I-set PF07679.16 CDW53929.1 - 3.1e-64 213.1 0.0 1.4e-19 70.0 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW53929.1 - 3.8e-59 197.2 0.2 6.5e-18 65.1 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 CDW53929.1 - 6.1e-38 129.0 0.1 5.1e-11 42.7 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 CDW53929.1 - 1.1e-35 121.6 0.0 1.1e-11 44.7 0.0 3.9 4 0 0 4 4 4 3 Immunoglobulin domain LRR_8 PF13855.6 CDW53929.1 - 2.3e-31 107.3 28.8 1.5e-12 47.1 2.4 3.3 2 1 2 4 4 4 3 Leucine rich repeat V-set PF07686.17 CDW53929.1 - 6.6e-16 58.5 2.4 0.0032 17.6 0.1 7.3 4 3 0 5 5 5 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW53929.1 - 3.4e-12 46.2 0.3 0.017 15.2 0.0 4.0 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain LRR_5 PF13306.6 CDW53929.1 - 1.1e-08 35.2 0.0 3.5e-08 33.5 0.0 1.8 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 CDW53929.1 - 2.9e-07 30.7 7.3 0.0019 18.5 1.1 3.1 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) Ig_6 PF18452.1 CDW53929.1 - 8.1e-07 28.5 0.0 0.047 13.3 0.0 3.9 4 0 0 4 4 4 1 Immunoglobulin domain Ig_5 PF16681.5 CDW53929.1 - 3.3e-05 24.2 0.0 0.48 10.9 0.0 3.9 3 1 0 3 3 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain BiPBP_C PF06832.12 CDW53929.1 - 0.0025 17.8 0.0 0.33 11.0 0.0 2.8 2 0 0 2 2 2 1 Penicillin-Binding Protein C-terminus Family Izumo-Ig PF16706.5 CDW53929.1 - 0.0081 16.2 0.0 17 5.6 0.0 3.8 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Ins_beta PF03488.14 CDW53929.1 - 0.052 13.6 0.1 0.13 12.3 0.1 1.6 1 0 0 1 1 1 0 Nematode insulin-related peptide beta type LRR_1 PF00560.33 CDW53929.1 - 0.14 12.8 6.8 14 6.7 0.1 5.4 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_9 PF14580.6 CDW53929.1 - 0.23 11.0 0.5 2 7.9 0.3 1.9 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 CDW53929.1 - 1.8 8.8 5.0 90 3.5 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich repeat Aminotran_1_2 PF00155.21 CDW53930.1 - 7.9e-72 242.4 0.0 1e-71 242.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II WD40 PF00400.32 CDW53931.1 - 1.8e-05 25.4 0.3 0.022 15.6 0.0 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Rhodanese PF00581.20 CDW53932.1 - 1.6e-14 54.3 0.0 2.4e-14 53.7 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain GYF PF02213.16 CDW53933.1 - 6.2e-14 51.4 1.9 1.5e-13 50.2 1.9 1.7 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 CDW53933.1 - 0.02 14.7 0.0 0.051 13.4 0.0 1.7 1 0 0 1 1 1 0 GYF domain 2 bacHORMA_1 PF18138.1 CDW53933.1 - 0.053 13.4 0.5 0.092 12.6 0.5 1.3 1 0 0 1 1 1 0 Bacterial HORMA domain family 1 Mcl1_mid PF12341.8 CDW53933.1 - 0.17 11.2 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region Peptidase_S15 PF02129.18 CDW53933.1 - 7.3 6.1 6.0 14 5.2 0.4 2.9 2 1 1 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) Glyco_transf_54 PF04666.13 CDW53934.1 - 4.4e-97 324.4 0.0 8.7e-97 323.5 0.0 1.4 2 0 0 2 2 2 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DPPIV_rep PF18811.1 CDW53934.1 - 0.015 15.2 1.0 0.59 10.1 0.1 2.7 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) low complexity region Pkinase PF00069.25 CDW53935.1 - 8.9e-28 97.4 0.0 1.1e-27 97.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53935.1 - 1.2e-21 77.2 0.0 1.4e-21 76.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW53935.1 - 5.4e-06 25.4 0.1 7.4e-06 25.0 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDW53935.1 - 0.033 13.5 0.1 0.57 9.5 0.0 2.1 2 0 0 2 2 2 0 Kinase-like ABC1 PF03109.16 CDW53935.1 - 0.099 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC1 family DAGK_acc PF00609.19 CDW53936.1 - 1e-40 139.7 0.0 1.8e-40 138.9 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain JAB PF01398.21 CDW53936.1 - 2.6e-25 88.7 0.0 8.4e-25 87.1 0.0 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DAGK_cat PF00781.24 CDW53936.1 - 3.6e-18 65.4 0.0 7.5e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Prok-JAB PF14464.6 CDW53936.1 - 1.9e-09 37.3 0.0 3.5e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain C1_1 PF00130.22 CDW53936.1 - 7.4e-09 35.4 29.2 5.6e-08 32.6 11.2 2.9 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) BRCC36_C PF18110.1 CDW53936.1 - 2.3e-05 24.4 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 BRCC36 C-terminal helical domain C1_2 PF03107.16 CDW53936.1 - 2.3 8.6 20.0 5.3 7.4 8.7 2.7 2 0 0 2 2 2 0 C1 domain AAA PF00004.29 CDW53937.1 - 4.2e-90 299.0 0.0 4.1e-44 150.2 0.0 3.5 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW53937.1 - 4.3e-25 87.3 0.1 2.4e-11 43.2 0.1 2.6 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 CDW53937.1 - 2.8e-12 46.7 0.0 0.00014 21.6 0.0 3.0 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDW53937.1 - 7.1e-12 45.8 0.0 8.7e-05 22.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDW53937.1 - 8.6e-11 42.5 5.1 0.004 17.5 0.5 4.9 3 2 1 4 4 4 2 AAA ATPase domain AAA_14 PF13173.6 CDW53937.1 - 1.2e-10 41.5 0.0 0.00021 21.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CDW53937.1 - 8.9e-10 38.7 0.5 0.001 19.1 0.0 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CDW53937.1 - 1.1e-09 38.0 0.1 0.0015 17.8 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 CDW53937.1 - 4.6e-09 36.7 4.6 0.0038 17.5 0.1 4.6 3 2 1 4 4 3 2 AAA domain AAA_33 PF13671.6 CDW53937.1 - 2.8e-08 34.1 0.0 0.0029 17.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 CDW53937.1 - 1.4e-07 31.6 0.2 0.00025 21.0 0.0 2.7 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 CDW53937.1 - 1.4e-07 32.1 0.0 0.016 15.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CDW53937.1 - 1.6e-07 31.2 0.4 0.0043 16.8 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDW53937.1 - 3.1e-07 30.0 0.2 0.018 14.4 0.1 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CDW53937.1 - 1.2e-06 28.8 0.0 0.059 13.8 0.0 2.7 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.27 CDW53937.1 - 3.7e-06 27.5 0.0 0.067 13.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter NACHT PF05729.12 CDW53937.1 - 4e-06 26.8 0.5 0.17 11.8 0.0 4.2 3 1 0 4 4 4 1 NACHT domain AAA_28 PF13521.6 CDW53937.1 - 6.6e-06 26.5 0.0 0.18 12.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CDW53937.1 - 9.7e-06 25.5 0.0 0.15 11.8 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 CDW53937.1 - 3.2e-05 24.4 0.0 0.15 12.5 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CDW53937.1 - 4.6e-05 23.0 0.0 0.42 10.1 0.0 3.1 2 2 0 2 2 2 2 P-loop containing dynein motor region Cytidylate_kin2 PF13189.6 CDW53937.1 - 7.4e-05 22.9 0.0 0.096 12.8 0.0 2.3 2 0 0 2 2 2 2 Cytidylate kinase-like family TsaE PF02367.17 CDW53937.1 - 8.7e-05 22.5 0.0 0.085 12.9 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 CDW53937.1 - 0.00013 21.7 0.0 1.5 8.5 0.0 3.6 3 1 0 3 3 3 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 CDW53937.1 - 0.00024 20.5 0.1 0.48 9.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin Sigma54_activ_2 PF14532.6 CDW53937.1 - 0.00027 21.1 0.0 0.44 10.6 0.0 3.3 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.11 CDW53937.1 - 0.00045 20.1 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 CDW53937.1 - 0.00049 19.3 0.0 0.17 11.0 0.1 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 NB-ARC PF00931.22 CDW53937.1 - 0.00056 19.2 0.2 0.94 8.6 0.1 2.4 2 0 0 2 2 2 2 NB-ARC domain SKI PF01202.22 CDW53937.1 - 0.00062 19.9 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 2 Shikimate kinase Vps4_C PF09336.10 CDW53937.1 - 0.001 19.0 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ATPase PF06745.13 CDW53937.1 - 0.0017 17.7 0.6 3 7.1 0.0 3.3 3 0 0 3 3 3 1 KaiC AAA_25 PF13481.6 CDW53937.1 - 0.0026 17.4 2.0 5 6.6 0.0 3.7 3 1 1 4 4 4 0 AAA domain DUF815 PF05673.13 CDW53937.1 - 0.0028 16.8 0.0 0.57 9.3 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 CDW53937.1 - 0.0035 17.3 0.3 16 5.3 0.1 3.8 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 CDW53937.1 - 0.0051 16.6 0.0 1.2 8.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 CDW53937.1 - 0.0061 16.0 0.2 3.7 7.0 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.6 CDW53937.1 - 0.0082 16.5 0.6 3.6 7.9 0.0 2.8 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 CDW53937.1 - 0.013 14.8 0.0 4 6.6 0.0 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) ATP-synt_ab PF00006.25 CDW53937.1 - 0.017 14.8 0.0 0.34 10.5 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 CDW53937.1 - 0.021 14.6 0.0 6.7 6.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain ADK PF00406.22 CDW53937.1 - 0.025 14.7 0.0 5.9 7.0 0.0 2.6 2 0 0 2 2 2 0 Adenylate kinase TniB PF05621.11 CDW53937.1 - 0.049 13.0 0.0 7.9 5.8 0.0 3.3 3 1 0 4 4 3 0 Bacterial TniB protein NTPase_1 PF03266.15 CDW53937.1 - 0.052 13.5 0.4 17 5.3 0.0 3.2 3 1 0 3 3 3 0 NTPase DAP3 PF10236.9 CDW53937.1 - 0.075 12.2 0.0 3 6.9 0.0 2.4 3 0 0 3 3 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_23 PF13476.6 CDW53937.1 - 0.075 13.5 0.7 21 5.5 0.0 2.8 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDW53937.1 - 0.085 12.6 0.0 17 5.2 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 CDW53937.1 - 0.11 12.2 0.1 11 5.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Abhydrolase_6 PF12697.7 CDW53938.1 - 0.00032 21.4 0.0 0.0004 21.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 CDW53938.1 - 0.04 13.4 0.0 0.086 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LCAT PF02450.15 CDW53938.1 - 0.043 13.0 0.0 0.084 12.0 0.0 1.4 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 CDW53938.1 - 0.1 11.9 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 zf-H2C2_2 PF13465.6 CDW53939.1 - 1.4e-06 28.4 19.3 6.7e-06 26.3 6.7 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW53939.1 - 8.8e-06 26.1 17.9 0.00016 22.2 5.5 2.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW53939.1 - 0.00067 20.0 24.1 0.0083 16.5 8.0 2.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type DUF899 PF05988.12 CDW53939.1 - 0.002 17.7 0.4 0.0025 17.4 0.4 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) Myc_N PF01056.18 CDW53939.1 - 0.0023 17.9 0.5 0.0027 17.7 0.5 1.2 1 0 0 1 1 1 1 Myc amino-terminal region zf-C2H2_6 PF13912.6 CDW53939.1 - 0.0042 17.1 5.7 0.0042 17.1 5.7 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 CDW53939.1 - 1.7 9.1 7.5 17 5.9 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW53939.1 - 3.3 8.1 9.9 11 6.4 3.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Ribosomal_L1 PF00687.21 CDW53940.1 - 1.7e-25 90.0 0.0 2.5e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF872 PF05915.12 CDW53941.1 - 7.7e-11 42.2 1.5 9.4e-11 41.9 1.5 1.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) WAP PF00095.21 CDW53942.1 - 1.3e-13 51.1 38.1 2.1e-05 24.8 4.3 3.1 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' Conotoxin_I2 PF17557.2 CDW53942.1 - 3.7 7.7 30.0 1.1 9.4 3.4 3.4 3 0 0 3 3 3 0 I2-superfamily conotoxins TUDOR PF00567.24 CDW53943.1 - 3.1e-20 72.4 0.0 4.1e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Tudor domain RNA_pol_Rpb8 PF03870.15 CDW53945.1 - 9e-47 158.8 0.6 1.3e-46 158.2 0.6 1.3 1 1 0 1 1 1 1 RNA polymerase Rpb8 TbpB_C PF17483.2 CDW53945.1 - 0.049 14.0 0.1 0.065 13.6 0.1 1.4 1 1 0 1 1 1 0 C-lobe handle domain of Tf-binding protein B MraZ PF02381.18 CDW53945.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 MraZ protein, putative antitoxin-like WW PF00397.26 CDW53946.1 - 1.5e-08 34.6 0.7 3.1e-08 33.5 0.7 1.6 1 0 0 1 1 1 1 WW domain Noggin PF05806.12 CDW53947.1 - 0.016 15.1 1.3 0.018 15.0 1.3 1.2 1 0 0 1 1 1 0 Noggin Gemin7 PF11095.8 CDW53948.1 - 3.9e-14 52.3 0.0 4.5e-14 52.1 0.0 1.0 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) G-gamma PF00631.22 CDW53949.1 - 1e-11 44.7 0.1 1.1e-11 44.6 0.1 1.0 1 0 0 1 1 1 1 GGL domain Ion_trans_2 PF07885.16 CDW53950.1 - 4.6e-54 180.3 33.3 1.2e-18 66.8 13.6 3.6 3 0 0 3 3 3 3 Ion channel Ion_trans PF00520.31 CDW53950.1 - 7.4e-15 54.8 13.9 1.3e-05 24.6 1.2 3.2 3 0 0 3 3 3 3 Ion transport protein RAMP4 PF06624.12 CDW53950.1 - 0.0012 18.9 0.3 11 6.2 0.1 3.8 3 0 0 3 3 3 1 Ribosome associated membrane protein RAMP4 SNARE_assoc PF09335.11 CDW53950.1 - 0.011 16.2 3.6 2.8 8.5 0.0 3.5 3 0 0 3 3 3 0 SNARE associated Golgi protein DUF4519 PF15012.6 CDW53950.1 - 0.018 15.2 0.2 2.8 8.2 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4519) Herpes_UL37_2 PF07413.11 CDW53950.1 - 0.029 13.6 0.0 4.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Betaherpesvirus immediate-early glycoprotein UL37 Lig_chan PF00060.26 CDW53950.1 - 0.065 13.1 9.8 0.72 9.7 0.1 3.5 3 2 1 4 4 4 0 Ligand-gated ion channel DUF5070 PF16802.5 CDW53950.1 - 0.13 12.2 0.1 0.45 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5070) EB PF01683.18 CDW53951.1 - 1.8e-12 47.3 6.9 2.6e-12 46.8 6.9 1.2 1 0 0 1 1 1 1 EB module Dickkopf_N PF04706.12 CDW53951.1 - 0.041 14.4 4.1 0.041 14.4 4.1 2.0 2 1 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region hEGF PF12661.7 CDW53951.1 - 9.7 7.0 23.7 0.28 11.9 8.0 4.5 5 0 0 5 5 5 0 Human growth factor-like EGF ketoacyl-synt PF00109.26 CDW53952.1 - 1e-67 228.4 0.0 1.7e-67 227.7 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CDW53952.1 - 6.3e-67 226.3 0.0 1.3e-66 225.3 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CDW53952.1 - 3.1e-48 164.1 0.0 7.3e-48 162.9 0.0 1.7 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 CDW53952.1 - 1.8e-38 131.2 0.1 3.7e-38 130.2 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CDW53952.1 - 5.1e-34 117.1 0.0 1.3e-33 115.8 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thioesterase PF00975.20 CDW53952.1 - 5.9e-26 92.0 0.0 1.3e-25 90.8 0.0 1.7 1 0 0 1 1 1 1 Thioesterase domain ADH_zinc_N_2 PF13602.6 CDW53952.1 - 4.3e-16 60.2 0.0 1.8e-14 54.9 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CDW53952.1 - 2.9e-15 56.4 0.0 6.5e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PS-DH PF14765.6 CDW53952.1 - 2.6e-10 40.0 0.0 8.6e-10 38.3 0.0 1.7 1 1 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 CDW53952.1 - 9e-07 29.2 0.3 3.5e-06 27.3 0.3 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 CDW53952.1 - 0.00012 21.6 0.0 0.0011 18.5 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_23 PF13489.6 CDW53952.1 - 0.00057 19.8 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain ACP_syn_III PF08545.10 CDW53952.1 - 0.008 16.0 0.2 0.024 14.5 0.2 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CDW53952.1 - 0.013 14.9 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Abhydrolase_1 PF00561.20 CDW53952.1 - 0.016 14.9 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold ACP_syn_III_C PF08541.10 CDW53952.1 - 0.16 12.2 0.3 6.7 7.0 0.0 3.5 4 0 0 4 4 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Neuralized PF07177.12 CDW53953.1 - 4.1e-37 127.5 0.0 5e-37 127.2 0.0 1.0 1 0 0 1 1 1 1 Neuralized zf-C3HC4_3 PF13920.6 CDW53954.1 - 3.6e-15 55.6 7.0 4.7e-15 55.2 7.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW53954.1 - 3.8e-07 30.3 7.4 6.7e-07 29.5 7.4 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 CDW53954.1 - 1.2e-06 28.2 5.7 2e-06 27.6 5.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 CDW53954.1 - 0.00016 21.5 8.2 0.00024 20.9 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW53954.1 - 0.00038 20.4 9.0 0.001 18.9 9.1 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_4 PF14570.6 CDW53954.1 - 0.00079 19.2 8.3 0.0013 18.5 8.3 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 CDW53954.1 - 0.00095 18.8 5.8 0.0019 17.8 5.8 1.6 1 1 0 1 1 1 1 P-11 zinc finger RecR PF02132.15 CDW53954.1 - 0.034 13.7 8.0 0.17 11.5 2.2 2.8 2 1 0 2 2 2 0 RecR protein zinc-ribbons_6 PF07191.12 CDW53954.1 - 0.48 10.5 6.1 0.51 10.4 4.7 1.9 2 1 0 2 2 2 0 zinc-ribbons zf-RING_UBOX PF13445.6 CDW53954.1 - 0.92 9.6 8.9 2.6 8.2 2.0 2.8 3 0 0 3 3 3 0 RING-type zinc-finger Y_phosphatase PF00102.27 CDW53955.1 - 1.9e-57 194.5 0.0 2.3e-57 194.3 0.0 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW53955.1 - 1e-06 28.9 0.0 1.5e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CDW53955.1 - 0.00016 21.5 0.0 0.00033 20.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW53955.1 - 0.021 15.0 0.4 0.049 13.7 0.4 1.9 1 1 0 1 1 1 0 Inositol hexakisphosphate Myotub-related PF06602.14 CDW53955.1 - 0.028 13.3 0.0 0.039 12.9 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain RCC_reductase PF06405.11 CDW53955.1 - 0.038 13.2 0.0 0.45 9.7 0.0 2.0 1 1 1 2 2 2 0 Red chlorophyll catabolite reductase (RCC reductase) MRG PF05712.13 CDW53956.1 - 1.3e-21 76.9 3.6 1.9e-21 76.3 3.6 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 CDW53956.1 - 3.5e-15 55.6 0.6 7.2e-15 54.6 0.6 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 CDW53956.1 - 0.00072 19.4 0.9 0.0015 18.4 0.9 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor_2 PF18104.1 CDW53956.1 - 0.003 17.2 0.1 0.0062 16.2 0.1 1.6 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain NOG1_N PF17835.1 CDW53956.1 - 0.035 14.1 0.2 0.084 12.8 0.1 1.6 2 0 0 2 2 2 0 NOG1 N-terminal helical domain PDGF_N PF04692.13 CDW53956.1 - 0.13 13.0 1.4 0.34 11.7 1.4 1.7 1 0 0 1 1 1 0 Platelet-derived growth factor, N terminal region Actin_micro PF17003.5 CDW53957.1 - 0.52 9.4 6.1 25 3.9 6.1 2.2 1 1 0 1 1 1 0 Putative actin-like family Elf1 PF05129.13 CDW53957.1 - 0.81 9.8 5.5 0.64 10.1 3.3 1.9 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like RRM_1 PF00076.22 CDW53958.1 - 1.8e-33 114.1 0.0 5.2e-16 58.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW53958.1 - 1.3e-06 28.4 0.5 0.034 14.3 0.2 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 CDW53958.1 - 0.00059 19.8 2.3 0.019 15.0 1.6 2.4 2 1 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 CDW53958.1 - 0.0028 17.6 0.1 0.018 15.0 0.1 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif NID PF07292.13 CDW53958.1 - 0.02 15.5 0.1 4.1 8.1 0.0 2.4 2 0 0 2 2 2 0 Nmi/IFP 35 domain (NID) GRP PF07172.11 CDW53958.1 - 0.028 15.1 10.0 0.057 14.1 10.0 1.5 1 0 0 1 1 1 0 Glycine rich protein family OB_RNB PF08206.11 CDW53958.1 - 0.051 13.3 0.1 3.8 7.3 0.0 2.7 2 0 0 2 2 2 0 Ribonuclease B OB domain Regnase_1_C PF18561.1 CDW53958.1 - 0.084 12.6 0.4 0.34 10.7 0.0 2.0 2 0 0 2 2 2 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain Nucleoporin_N PF08801.11 CDW53959.1 - 0.017 13.9 0.0 0.12 11.1 0.0 2.0 2 0 0 2 2 2 0 Nup133 N terminal like WD40 PF00400.32 CDW53959.1 - 0.02 15.7 2.1 0.069 14.1 0.2 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Sdh5 PF03937.16 CDW53960.1 - 9.7e-19 67.1 0.0 1.4e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase Asparaginase_2 PF01112.18 CDW53961.1 - 3e-74 249.8 1.4 3.5e-74 249.6 1.4 1.0 1 0 0 1 1 1 1 Asparaginase KH_1 PF00013.29 CDW53963.1 - 2.1e-32 110.7 9.1 1.9e-17 62.8 0.2 2.3 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 CDW53963.1 - 1.9e-08 34.0 1.5 0.0012 18.7 0.0 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 CDW53963.1 - 4.9e-05 23.1 1.0 0.062 13.2 0.8 2.4 2 0 0 2 2 2 2 KH domain KH_5 PF13184.6 CDW53963.1 - 0.0033 17.5 2.0 2 8.6 0.3 2.4 2 0 0 2 2 2 2 NusA-like KH domain MRP-L51 PF10244.9 CDW53964.1 - 2.5e-39 133.4 2.0 4.1e-39 132.7 2.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit Ribosomal_L18p PF00861.22 CDW53965.1 - 0.063 13.6 0.0 0.091 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Methyltransf_10 PF05971.12 CDW53966.1 - 1.9e-72 244.1 0.0 2.6e-72 243.7 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 CDW53966.1 - 0.0019 17.8 0.0 0.0032 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CDW53966.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) GidB PF02527.15 CDW53966.1 - 0.084 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G AIRS_C PF02769.22 CDW53967.1 - 4.2e-26 91.9 0.1 8e-26 91.0 0.1 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CDW53967.1 - 4.2e-08 33.7 0.2 1.3e-07 32.2 0.1 1.8 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain DUF3956 PF13104.6 CDW53967.1 - 0.022 15.0 0.1 1.1 9.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3956) UxaC PF02614.14 CDW53967.1 - 0.026 13.4 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Glucuronate isomerase DUF4756 PF15948.5 CDW53967.1 - 0.18 11.6 0.0 70 3.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4756) eIF-6 PF01912.18 CDW53968.1 - 1e-75 253.5 3.2 1.3e-75 253.1 3.2 1.1 1 0 0 1 1 1 1 eIF-6 family Cpn60_TCP1 PF00118.24 CDW53969.1 - 5e-151 503.7 11.7 6.6e-151 503.3 11.7 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NOPS PF08075.11 CDW53970.1 - 0.032 14.4 0.1 0.051 13.8 0.1 1.3 1 0 0 1 1 1 0 NOPS (NUC059) domain CAF1 PF04857.20 CDW53971.1 - 1.9e-19 70.0 0.3 2.9e-10 39.8 0.0 2.7 2 1 0 2 2 2 2 CAF1 family ribonuclease Vps39_1 PF10366.9 CDW53973.1 - 1.4e-27 96.1 3.2 1.5e-27 96.0 1.1 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 CDW53973.1 - 8.7e-21 74.4 0.5 8.9e-20 71.2 0.1 2.7 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 CDW53973.1 - 1.2e-12 48.0 0.0 5.9e-12 45.8 0.0 2.0 2 0 0 2 2 2 1 CNH domain Clathrin PF00637.20 CDW53973.1 - 9.3e-12 45.0 5.3 1e-06 28.7 0.7 2.6 2 0 0 2 2 2 2 Region in Clathrin and VPS DUF2175 PF09943.9 CDW53973.1 - 0.026 14.8 0.7 0.1 12.9 0.7 2.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) IFT57 PF10498.9 CDW53974.1 - 5.9e-76 255.8 11.7 2.9e-75 253.5 11.7 1.8 1 1 0 1 1 1 1 Intra-flagellar transport protein 57 EzrA PF06160.12 CDW53974.1 - 0.0048 15.1 3.9 0.0048 15.1 3.9 2.2 2 1 0 3 3 3 1 Septation ring formation regulator, EzrA Sec8_exocyst PF04048.14 CDW53974.1 - 0.098 12.5 2.4 0.38 10.6 0.9 2.8 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain DUF948 PF06103.11 CDW53974.1 - 0.18 12.0 1.9 6.3 7.1 0.0 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Carbpep_Y_N PF05388.11 CDW53974.1 - 0.33 11.5 3.4 3.5 8.2 0.1 3.2 2 1 1 3 3 3 0 Carboxypeptidase Y pro-peptide ABC_tran_CTD PF16326.5 CDW53974.1 - 0.59 10.4 5.4 0.27 11.5 0.8 2.9 2 1 0 2 2 2 0 ABC transporter C-terminal domain TMPIT PF07851.13 CDW53974.1 - 2.1 7.5 6.1 2.7 7.2 1.2 2.2 1 1 1 2 2 2 0 TMPIT-like protein TPR_MLP1_2 PF07926.12 CDW53974.1 - 2.8 8.0 14.0 0.23 11.5 7.3 2.5 2 2 0 2 2 2 0 TPR/MLP1/MLP2-like protein Exonuc_VII_L PF02601.15 CDW53974.1 - 7.2 6.1 10.1 44 3.5 10.1 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Skp1 PF01466.19 CDW53975.1 - 1.6e-28 98.6 0.6 3.5e-28 97.5 0.6 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 CDW53975.1 - 8e-22 77.2 0.4 1.9e-21 76.0 0.2 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Patatin PF01734.22 CDW53976.1 - 3.4e-17 63.3 0.7 1.8e-16 61.0 0.3 2.1 2 1 0 2 2 2 1 Patatin-like phospholipase LBP_BPI_CETP_C PF02886.17 CDW53977.1 - 3.1e-16 59.6 0.0 1.2e-15 57.6 0.0 1.8 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 CDW53977.1 - 0.00015 21.4 0.0 0.00048 19.8 0.0 1.9 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Ribosomal_L28e PF01778.17 CDW53979.1 - 1.3e-19 71.0 1.4 2e-19 70.4 1.4 1.3 1 0 0 1 1 1 1 Ribosomal L28e protein family Ribosomal_S8 PF00410.19 CDW53979.1 - 0.1 12.5 1.7 0.13 12.2 1.7 1.2 1 0 0 1 1 1 0 Ribosomal protein S8 DEAD PF00270.29 CDW53980.1 - 6.9e-30 104.1 0.1 1.1e-29 103.4 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW53980.1 - 4.5e-21 75.3 0.0 1.7e-20 73.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW53980.1 - 4.6e-06 26.7 0.0 6.9e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDW53980.1 - 0.034 13.9 0.0 0.087 12.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDW53980.1 - 0.037 14.4 0.0 1.8 8.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain Glyco_tranf_2_3 PF13641.6 CDW53980.1 - 0.088 12.7 0.2 18 5.1 0.0 2.4 2 0 0 2 2 2 0 Glycosyltransferase like family 2 DUF2517 PF10725.9 CDW53980.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2517) Trypsin PF00089.26 CDW53981.1 - 6.3e-09 36.0 0.0 1.2e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Trypsin HLH PF00010.26 CDW53982.1 - 2.9e-16 59.2 0.7 3.7e-16 58.8 0.7 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Pallilysin PF18663.1 CDW53982.1 - 0.16 11.9 0.0 0.4 10.7 0.0 1.5 2 0 0 2 2 2 0 Pallilysin beta barrel domain DUF3510 PF12022.8 CDW53984.1 - 2.5e-21 76.4 0.1 9.5e-21 74.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) COG2 PF06148.11 CDW53984.1 - 1.7e-13 50.8 4.1 1.7e-13 50.8 4.1 2.4 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Ig_3 PF13927.6 CDW53984.1 - 2.7e-05 24.7 0.0 0.00042 20.9 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 CDW53984.1 - 0.0097 16.0 0.0 0.021 14.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin I-set domain EGF PF00008.27 CDW53984.1 - 0.049 13.9 3.1 0.13 12.6 3.1 1.8 1 0 0 1 1 1 0 EGF-like domain Sec34 PF04136.15 CDW53984.1 - 0.15 12.0 7.5 0.087 12.7 1.3 3.2 3 0 0 3 3 3 0 Sec34-like family FNIP_M PF14637.6 CDW53984.1 - 0.38 10.7 4.8 0.15 12.1 1.6 1.9 2 0 0 2 2 2 0 Folliculin-interacting protein middle domain Corazonin PF17308.2 CDW53984.1 - 0.41 11.0 3.8 20 5.6 0.1 2.7 1 1 1 2 2 2 0 Pro-corazonin Vps51 PF08700.11 CDW53984.1 - 2.8 8.1 5.6 1.4 9.0 0.1 3.3 3 1 0 3 3 3 0 Vps51/Vps67 Mpv17_PMP22 PF04117.12 CDW53985.1 - 5.2e-23 81.0 0.9 1e-22 80.1 0.9 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family His_Phos_2 PF00328.22 CDW53986.1 - 3.9e-20 72.6 0.0 4.4e-19 69.1 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Neur_chan_LBD PF02931.23 CDW53986.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain NinD PF17466.2 CDW53986.1 - 0.13 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function Exostosin PF03016.15 CDW53987.1 - 1.4e-49 168.9 0.0 2.3e-49 168.2 0.0 1.2 1 0 0 1 1 1 1 Exostosin family Glyco_transf_64 PF09258.10 CDW53987.1 - 1.1e-18 67.5 0.0 2.6e-18 66.2 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 64 domain Pkinase PF00069.25 CDW53989.1 - 6.5e-45 153.5 0.0 7.6e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53989.1 - 1.4e-17 63.9 0.0 2.4e-17 63.1 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CDW53989.1 - 0.051 13.5 2.1 5.3 6.9 0.1 3.0 2 1 0 3 3 3 0 Phosphotransferase enzyme family PEGSRP PF07623.11 CDW53989.1 - 0.16 11.8 0.2 0.29 11.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1584) ECSIT PF06239.11 CDW53989.1 - 0.46 9.6 3.0 4 6.5 0.4 2.6 3 1 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway TTR-52 PF01060.23 CDW53990.1 - 1.6e-23 83.2 0.0 2e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family Glyco_hydro_18 PF00704.28 CDW53991.1 - 1.1e-38 133.8 0.0 1.4e-20 74.3 0.1 3.4 3 1 0 3 3 3 3 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.13 CDW53991.1 - 0.0065 15.9 0.1 0.31 10.4 0.1 2.6 3 0 0 3 3 3 1 Glycosyl hydrolase family 85 MS_channel PF00924.18 CDW53991.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel B9-C2 PF07162.11 CDW53993.1 - 1.9e-46 158.3 0.1 2.5e-46 158.0 0.1 1.2 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein TGFb_propeptide PF00688.18 CDW53994.1 - 4.4e-38 131.4 0.0 5.8e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 TGF-beta propeptide TGF_beta PF00019.20 CDW53994.1 - 4.4e-35 120.8 0.2 1e-34 119.6 0.2 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain DUF758 PF05527.11 CDW53995.1 - 8.8e-07 29.1 0.6 9.6e-07 29.0 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF758) adh_short PF00106.25 CDW53996.1 - 1.7e-31 109.2 0.0 2.1e-30 105.6 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW53996.1 - 8.1e-25 87.7 0.0 1.5e-23 83.6 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW53996.1 - 9.8e-09 35.4 0.0 1.4e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDW53996.1 - 0.004 16.7 0.0 0.006 16.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family YflT PF11181.8 CDW53996.1 - 0.025 15.1 0.0 0.072 13.6 0.0 1.7 2 0 0 2 2 2 0 Heat induced stress protein YflT EF_assoc_2 PF08356.12 CDW53996.1 - 0.11 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 EF hand associated Pkinase PF00069.25 CDW53997.1 - 1.3e-64 218.2 0.0 1.8e-64 217.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW53997.1 - 1.1e-42 146.1 0.0 1.8e-42 145.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CNH PF00780.22 CDW53997.1 - 9.6e-38 130.3 0.4 3.7e-37 128.4 0.4 1.9 1 1 0 1 1 1 1 CNH domain Pkinase_fungal PF17667.1 CDW53997.1 - 3.6e-05 22.7 0.0 8e-05 21.6 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CDW53997.1 - 0.0042 16.5 0.0 0.0075 15.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like adh_short PF00106.25 CDW53998.1 - 1.2e-18 67.3 0.0 3.1e-17 62.7 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW53998.1 - 6.4e-11 42.3 0.1 4.6e-10 39.5 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CDW53998.1 - 0.011 15.1 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Actin PF00022.19 CDW53999.1 - 4.3e-37 127.7 0.1 1.1e-20 73.7 0.0 2.1 1 1 1 2 2 2 2 Actin NACHT PF05729.12 CDW53999.1 - 0.0034 17.3 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 NACHT domain TGS PF02824.21 CDW54000.1 - 2.2e-05 24.4 0.0 6.9e-05 22.8 0.0 1.8 2 0 0 2 2 2 1 TGS domain Med6 PF04934.14 CDW54001.1 - 5.9e-35 120.0 0.1 9.1e-35 119.4 0.1 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component ORC5_C PF14630.6 CDW54002.1 - 0.051 13.1 0.2 3.9 6.9 0.1 2.0 1 1 1 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus MyTH4 PF00784.17 CDW54002.1 - 0.12 12.9 0.1 0.37 11.3 0.1 1.9 1 0 0 1 1 1 0 MyTH4 domain PTPRCAP PF15713.5 CDW54003.1 - 4.8 7.5 11.2 0.4 11.0 5.9 1.9 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Snf7 PF03357.21 CDW54004.1 - 5.7e-44 149.8 14.6 1.2e-24 86.8 6.6 2.0 2 0 0 2 2 2 2 Snf7 NPV_P10 PF05531.12 CDW54004.1 - 0.00046 20.6 2.7 0.0086 16.5 0.2 2.8 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein FlxA PF14282.6 CDW54004.1 - 0.0066 16.4 6.3 0.46 10.5 3.0 2.6 2 1 0 2 2 2 2 FlxA-like protein CCDC-167 PF15188.6 CDW54004.1 - 0.0083 16.4 5.4 0.61 10.5 0.8 2.4 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 167 FliJ PF02050.16 CDW54004.1 - 0.013 15.7 8.0 0.12 12.6 3.6 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein Spc7 PF08317.11 CDW54004.1 - 0.02 13.8 5.3 0.8 8.5 0.3 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein HTH_Tnp_Tc5 PF03221.16 CDW54004.1 - 0.032 14.3 0.2 0.07 13.2 0.2 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain DUF3080 PF11279.8 CDW54004.1 - 0.066 12.4 1.3 0.25 10.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3080) Glutaredoxin PF00462.24 CDW54004.1 - 0.1 12.9 1.8 2.1 8.6 0.1 3.0 2 1 1 3 3 3 0 Glutaredoxin PEP-utilisers_N PF05524.13 CDW54004.1 - 0.14 12.3 3.8 0.3 11.2 0.1 2.3 2 1 0 2 2 2 0 PEP-utilising enzyme, N-terminal YlbE PF14003.6 CDW54004.1 - 0.15 12.6 0.3 0.15 12.6 0.3 1.9 2 0 0 2 2 1 0 YlbE-like protein Prefoldin PF02996.17 CDW54004.1 - 0.23 11.4 7.0 3.8 7.5 0.0 2.9 3 1 0 3 3 3 0 Prefoldin subunit EMP24_GP25L PF01105.24 CDW54004.1 - 0.29 11.0 2.4 0.64 9.9 0.6 2.0 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD GCIP PF13324.6 CDW54004.1 - 0.52 9.9 5.1 0.6 9.7 4.5 1.4 1 1 1 2 2 2 0 Grap2 and cyclin-D-interacting ABC_tran_CTD PF16326.5 CDW54004.1 - 0.54 10.6 7.8 1.6 9.0 0.1 3.1 3 0 0 3 3 3 0 ABC transporter C-terminal domain Cupin_4 PF08007.12 CDW54004.1 - 0.59 9.5 5.2 1.1 8.6 0.4 2.0 1 1 1 2 2 2 0 Cupin superfamily protein FlaC_arch PF05377.11 CDW54004.1 - 0.81 10.1 6.9 16 6.0 0.6 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Prefoldin_2 PF01920.20 CDW54004.1 - 0.97 9.4 8.9 1.8 8.6 0.0 3.2 2 2 0 2 2 2 0 Prefoldin subunit FTCD_C PF04961.12 CDW54004.1 - 1.7 8.4 4.7 0.35 10.6 1.2 1.7 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase DUF5344 PF17279.2 CDW54004.1 - 2.1 9.0 7.3 2.1 9.0 0.2 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5344) FapA PF03961.13 CDW54004.1 - 3.9 6.0 10.6 2.5 6.6 3.2 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A CC PF04942.14 CDW54005.1 - 0.00017 21.7 73.6 0.0051 17.0 8.6 6.7 6 1 1 7 7 7 5 CC domain OPA3 PF07047.12 CDW54006.1 - 7.1e-39 132.4 0.1 9.3e-39 132.1 0.1 1.2 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) bZIP_2 PF07716.15 CDW54006.1 - 0.16 12.1 1.9 0.33 11.0 1.9 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Methyltransf_4 PF02390.17 CDW54007.1 - 4.2e-52 176.1 0.0 5.3e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 CDW54007.1 - 0.00023 21.8 0.1 0.0011 19.7 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW54007.1 - 0.0017 18.2 0.0 0.0021 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW54007.1 - 0.0018 17.9 0.0 0.0049 16.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDW54007.1 - 0.004 17.0 0.0 0.006 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW54007.1 - 0.0041 17.7 0.1 0.04 14.6 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW54007.1 - 0.008 16.9 0.0 0.027 15.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Lact_bio_phlase PF09508.10 CDW54007.1 - 0.037 12.5 0.0 0.049 12.1 0.0 1.1 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain CMAS PF02353.20 CDW54007.1 - 0.071 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase NAC PF01849.18 CDW54008.1 - 6.3e-24 83.7 0.3 1.2e-23 82.9 0.3 1.5 1 0 0 1 1 1 1 NAC domain DUF3149 PF11346.8 CDW54008.1 - 0.13 11.9 0.8 0.21 11.2 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) TRP PF06011.12 CDW54010.1 - 0.023 13.4 0.9 0.43 9.3 0.0 2.0 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Pkinase PF00069.25 CDW54011.1 - 5e-35 121.1 0.0 7e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54011.1 - 9.2e-34 116.9 0.0 1.4e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 CDW54011.1 - 4.7e-13 48.4 1.1 1.3e-12 47.0 1.1 1.8 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 CDW54011.1 - 5e-09 37.1 7.6 1.6e-08 35.5 6.5 2.2 2 0 0 2 2 2 1 Activin types I and II receptor domain FTA2 PF13095.6 CDW54011.1 - 0.00059 19.5 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CDW54011.1 - 0.0054 15.6 0.0 0.013 14.3 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CDW54011.1 - 0.019 14.9 0.0 0.044 13.7 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family tRNA-synt_1 PF00133.22 CDW54012.1 - 5.3e-231 768.1 0.0 1.7e-230 766.4 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDW54012.1 - 5.7e-26 91.3 0.1 5.3e-25 88.2 0.0 2.2 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDW54012.1 - 1.7e-12 46.8 0.2 0.0078 15.0 0.0 3.6 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CDW54012.1 - 0.023 14.1 0.0 0.057 12.8 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain SNF2_N PF00176.23 CDW54013.1 - 4.8e-62 209.7 0.0 1.1e-61 208.5 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW54013.1 - 2.2e-16 60.2 0.0 8.8e-16 58.2 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Requiem_N PF14051.6 CDW54013.1 - 0.039 14.2 0.1 0.12 12.6 0.1 1.8 1 0 0 1 1 1 0 N-terminal domain of DPF2/REQ. DEAD_2 PF06733.15 CDW54013.1 - 0.1 12.2 1.7 0.32 10.6 0.0 2.4 2 0 0 2 2 2 0 DEAD_2 DUF2540 PF10802.8 CDW54013.1 - 1.6 8.9 4.9 2.9 8.0 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2540) Fz PF01392.22 CDW54014.1 - 7e-17 62.1 7.4 1.2e-13 51.6 3.8 2.9 2 1 1 3 3 3 2 Fz domain NTR PF01759.21 CDW54014.1 - 7.8e-05 22.4 2.0 0.00062 19.5 2.0 2.2 1 1 0 1 1 1 1 UNC-6/NTR/C345C module Zip PF02535.22 CDW54015.1 - 7.5 5.7 12.9 9.7 5.3 12.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Abhydrolase_1 PF00561.20 CDW54016.1 - 7.3e-23 81.5 0.2 1.9e-22 80.2 0.2 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW54016.1 - 6.3e-20 72.7 3.0 6.3e-20 72.7 3.0 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDW54016.1 - 1.2e-12 47.6 0.0 2.1e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CDW54016.1 - 1.8e-06 26.8 0.0 2.7e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 CDW54016.1 - 0.00058 20.0 0.0 0.55 10.3 0.0 2.3 2 0 0 2 2 2 2 Thioesterase domain Abhydrolase_3 PF07859.13 CDW54016.1 - 0.01 15.7 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 CDW54016.1 - 0.022 13.6 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme LIDHydrolase PF10230.9 CDW54016.1 - 0.029 13.9 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Esterase PF00756.20 CDW54016.1 - 0.047 13.3 0.0 0.094 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative esterase Ser_hydrolase PF06821.13 CDW54016.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase PAF-AH_p_II PF03403.13 CDW54016.1 - 0.064 11.7 0.0 0.12 10.9 0.0 1.4 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Lipase_3 PF01764.25 CDW54016.1 - 0.077 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Peptidase_S9 PF00326.21 CDW54016.1 - 0.083 12.4 0.0 0.38 10.2 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 CDW54016.1 - 0.23 11.2 0.0 0.35 10.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.25 CDW54017.1 - 1.1e-52 179.0 0.0 1.5e-52 178.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54017.1 - 6e-22 78.2 0.0 2e-21 76.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CDW54017.1 - 9.1e-05 22.5 0.0 0.0011 18.9 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDW54017.1 - 0.016 14.9 0.0 0.05 13.2 0.0 1.8 1 1 0 1 1 1 0 RIO1 family LRR_6 PF13516.6 CDW54018.1 - 0.2 11.8 1.3 43 4.5 0.0 3.6 4 1 0 4 4 4 0 Leucine Rich repeat PPTA PF01239.22 CDW54019.1 - 3.8e-32 109.1 19.6 2.8e-10 39.6 0.9 7.0 7 0 0 7 7 7 5 Protein prenyltransferase alpha subunit repeat LRR_4 PF12799.7 CDW54019.1 - 9.8e-05 22.7 10.8 0.0089 16.4 2.1 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW54019.1 - 0.00083 18.9 1.4 0.004 16.7 0.3 2.2 2 0 0 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 CDW54019.1 - 0.064 13.0 8.4 2.9 7.7 3.0 2.9 2 1 1 3 3 3 0 Leucine rich repeat LRR_6 PF13516.6 CDW54019.1 - 0.087 12.9 1.7 37 4.7 0.1 3.9 3 0 0 3 3 3 0 Leucine Rich repeat MOZ_SAS PF01853.18 CDW54020.1 - 4.4e-77 257.8 1.0 6.7e-77 257.2 1.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CDW54020.1 - 1.6e-18 66.0 0.7 1.6e-18 66.0 0.7 2.0 2 0 0 2 2 2 1 MYST family zinc finger domain PHD PF00628.29 CDW54020.1 - 9.5e-08 31.8 23.3 0.00071 19.4 3.8 3.4 2 1 1 3 3 3 2 PHD-finger PHD_4 PF16866.5 CDW54020.1 - 0.001 19.1 6.8 0.001 19.1 6.8 3.2 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 CDW54020.1 - 0.12 12.3 20.6 0.66 9.9 9.2 3.6 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 CDW54020.1 - 3.2 7.9 19.2 0.057 13.5 5.7 3.2 2 1 1 3 3 3 0 KIAA1045 RING finger PH_9 PF15410.6 CDW54021.1 - 3.3e-39 134.0 0.1 3.2e-37 127.5 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain Sec7 PF01369.20 CDW54021.1 - 6.3e-22 78.1 0.1 1.1e-21 77.4 0.1 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 CDW54021.1 - 4.4e-10 40.0 0.1 1.8e-09 38.0 0.1 2.1 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 CDW54021.1 - 0.0085 15.9 0.0 0.067 13.0 0.0 2.3 3 0 0 3 3 3 1 Pleckstrin homology domain PCNA_C PF02747.15 CDW54022.1 - 1.7e-45 154.3 0.0 8.7e-45 152.0 0.0 1.9 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 CDW54022.1 - 8.6e-45 151.5 2.3 1.6e-30 105.4 0.6 2.4 1 1 1 2 2 2 2 Proliferating cell nuclear antigen, N-terminal domain Rad9 PF04139.13 CDW54022.1 - 0.0082 15.6 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Rad9 WYL PF13280.6 CDW54022.1 - 0.03 14.4 0.0 0.086 12.9 0.0 1.7 2 0 0 2 2 2 0 WYL domain Phage_X PF05155.15 CDW54022.1 - 0.17 12.3 0.0 0.73 10.3 0.0 1.9 2 0 0 2 2 2 0 Phage X family PAP2 PF01569.21 CDW54023.1 - 6.9e-19 68.0 2.6 6.9e-19 68.0 2.6 2.1 2 1 1 3 3 3 1 PAP2 superfamily PAP2_C PF14360.6 CDW54023.1 - 0.069 13.7 0.8 0.069 13.7 0.8 3.0 2 1 1 3 3 3 0 PAP2 superfamily C-terminal Y_phosphatase PF00102.27 CDW54024.1 - 4e-78 262.2 0.0 5.2e-78 261.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW54024.1 - 1.8e-05 24.8 0.0 3.2e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CDW54024.1 - 0.00019 21.3 0.0 0.00046 20.0 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW54024.1 - 0.00056 20.1 1.0 0.0067 16.5 0.0 2.8 3 1 0 4 4 4 1 Inositol hexakisphosphate tRNA-synt_2b PF00587.25 CDW54025.1 - 2.3e-39 135.2 0.0 3.5e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CDW54025.1 - 1.9e-15 57.0 2.9 2.9e-14 53.2 1.1 2.3 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Mito_fiss_reg PF05308.11 CDW54026.1 - 2.2 8.3 10.7 0.12 12.5 2.7 2.4 2 0 0 2 2 2 0 Mitochondrial fission regulator RNA_pol_Rpb2_6 PF00562.28 CDW54027.1 - 4e-128 427.8 0.7 5.6e-128 427.3 0.7 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CDW54027.1 - 6.3e-70 234.8 0.0 1e-69 234.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CDW54027.1 - 8.1e-54 182.2 0.0 4.7e-53 179.7 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CDW54027.1 - 9.9e-33 112.4 0.1 9.9e-33 112.4 0.1 2.1 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 CDW54027.1 - 1.7e-24 85.7 0.0 4e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 CDW54027.1 - 3.2e-24 85.0 0.9 6.7e-24 84.0 0.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 CDW54027.1 - 2.3e-18 66.5 0.1 5.4e-18 65.3 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 SPC12 PF06645.13 CDW54028.1 - 1.1e-25 89.5 1.4 1.4e-25 89.2 1.4 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF3040 PF11239.8 CDW54028.1 - 0.014 15.7 0.9 0.018 15.3 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) EpuA PF11772.8 CDW54028.1 - 0.15 11.8 2.1 0.28 10.9 2.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta DUF1757 PF08560.10 CDW54029.1 - 1e-35 122.9 0.0 1.3e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1757) HCO3_cotransp PF00955.21 CDW54031.1 - 1.8e-185 617.7 17.5 2.6e-185 617.1 17.5 1.2 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 CDW54031.1 - 2.9e-27 96.1 0.2 1.2e-10 41.6 0.0 3.2 1 1 2 3 3 3 3 Band 3 cytoplasmic domain Ala_racemase_C PF00842.21 CDW54031.1 - 0.15 11.9 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Alanine racemase, C-terminal domain HAD_2 PF13419.6 CDW54032.1 - 2.4e-22 79.9 0.0 2.8e-22 79.6 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW54032.1 - 2.8e-13 50.7 0.0 6.6e-12 46.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW54032.1 - 0.00055 19.9 0.0 0.00094 19.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CDW54032.1 - 0.00055 20.4 0.0 0.00071 20.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW54032.1 - 0.0094 16.0 0.0 0.33 11.1 0.0 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF4449 PF14613.6 CDW54032.1 - 0.3 11.2 0.6 0.42 10.7 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) HAD_2 PF13419.6 CDW54033.1 - 1e-20 74.6 0.0 1.2e-20 74.4 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW54033.1 - 5.4e-10 39.9 0.0 1.6e-08 35.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW54033.1 - 0.00048 20.1 0.0 0.0013 18.8 0.0 1.6 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 CDW54033.1 - 0.00056 20.4 0.0 0.0007 20.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW54033.1 - 0.013 15.6 0.0 0.37 10.9 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Tmemb_161AB PF10268.9 CDW54034.1 - 1.1e-22 80.3 8.3 7.8e-18 64.4 4.7 2.3 1 1 1 2 2 2 2 Predicted transmembrane protein 161AB MARVEL PF01284.23 CDW54036.1 - 1.7e-07 31.3 18.1 2.4e-07 30.9 18.1 1.1 1 0 0 1 1 1 1 Membrane-associating domain Cytochrom_B561 PF03188.16 CDW54036.1 - 0.17 12.0 9.4 0.29 11.3 8.2 1.9 1 1 1 2 2 2 0 Eukaryotic cytochrome b561 DUF3272 PF11676.8 CDW54036.1 - 0.55 10.5 3.8 31 4.9 0.5 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3272) DUF2070 PF09843.9 CDW54036.1 - 1.7 6.9 7.8 2 6.6 7.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) TssN PF17555.2 CDW54036.1 - 2.3 7.5 7.3 5.4 6.3 7.4 1.4 1 1 0 1 1 1 0 Type VI secretion system, TssN Frizzled PF01534.17 CDW54037.1 - 2.5e-47 161.5 19.2 2.3e-40 138.6 16.1 2.5 2 1 0 2 2 2 2 Frizzled/Smoothened family membrane region Fz PF01392.22 CDW54037.1 - 1.1e-27 96.8 8.1 1.1e-27 96.8 8.1 1.9 2 0 0 2 2 2 1 Fz domain LysM PF01476.20 CDW54039.1 - 9.2e-06 25.6 0.0 1.7e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 LysM domain Ribosomal_L4 PF00573.22 CDW54040.1 - 4.1e-35 121.2 0.1 6.3e-35 120.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 CDW54040.1 - 1.5e-21 76.2 2.1 1.5e-21 76.2 2.1 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain UCH PF00443.29 CDW54041.1 - 1.6e-58 198.2 0.2 3.5e-58 197.1 0.1 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW54041.1 - 2e-15 57.2 0.4 5.4e-15 55.8 0.4 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 CDW54041.1 - 9.6e-09 35.4 0.6 9.6e-09 35.4 0.6 2.0 2 0 0 2 2 2 1 USP8 dimerisation domain Rhodanese PF00581.20 CDW54041.1 - 0.00027 21.4 0.0 0.00063 20.2 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain LSM14 PF12701.7 CDW54042.1 - 4.1e-30 103.7 0.0 8e-30 102.8 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 CDW54042.1 - 4.5e-12 46.8 8.5 8.7e-12 45.8 8.5 1.4 1 0 0 1 1 1 1 FDF domain SM-ATX PF14438.6 CDW54042.1 - 7.6e-10 38.8 0.0 1.2e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF5320 PF17253.2 CDW54042.1 - 0.0024 18.9 0.7 0.0024 18.9 0.7 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5320) PCI PF01399.27 CDW54043.1 - 2.1e-08 34.6 0.1 3.3e-08 34.0 0.1 1.4 1 0 0 1 1 1 1 PCI domain HTH_11 PF08279.12 CDW54043.1 - 0.0077 16.2 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 HTH domain HTH_DeoR PF08220.12 CDW54043.1 - 0.054 13.2 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain PuR_N PF09182.10 CDW54043.1 - 0.066 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal RPN7 PF10602.9 CDW54044.1 - 7.3e-29 100.7 4.5 7.3e-29 100.7 4.5 1.9 2 0 0 2 2 2 1 26S proteasome subunit RPN7 Myosin_head PF00063.21 CDW54046.1 - 2.4e-224 746.5 1.1 3.1e-224 746.1 1.1 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) IQ PF00612.27 CDW54046.1 - 1.5e-18 64.8 29.5 1.3e-05 24.6 0.0 6.7 6 0 0 6 6 6 4 IQ calmodulin-binding motif DIL PF01843.19 CDW54046.1 - 6.8e-15 55.2 1.8 3.9e-14 52.8 1.8 2.4 1 0 0 1 1 1 1 DIL domain AAA_16 PF13191.6 CDW54046.1 - 0.00083 19.8 0.0 0.0035 17.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDW54046.1 - 0.00091 19.5 0.3 0.0096 16.2 0.0 2.7 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CDW54046.1 - 0.016 15.1 0.6 0.067 13.1 0.1 2.3 2 0 0 2 2 2 0 NACHT domain CbiA PF01656.23 CDW54046.1 - 0.18 11.9 0.0 0.45 10.6 0.0 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 CDW54046.1 - 0.22 10.5 0.0 0.43 9.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Piwi PF02171.17 CDW54047.1 - 4.5e-45 154.2 0.9 7.6e-45 153.4 0.9 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 CDW54047.1 - 1e-10 41.5 0.0 3e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 CDW54047.1 - 9.4e-09 35.5 0.0 6.3e-08 32.8 0.0 2.3 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoMid PF16487.5 CDW54047.1 - 3.6e-06 27.1 0.2 1.3e-05 25.3 0.2 2.0 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL1 PF08699.10 CDW54047.1 - 0.00045 19.8 0.0 0.00092 18.8 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 1 domain MSG PF02349.15 CDW54047.1 - 0.094 12.9 0.3 0.36 11.1 0.3 2.1 1 1 0 1 1 1 0 Major surface glycoprotein zf-C4 PF00105.18 CDW54048.1 - 9.8e-32 109.2 16.4 2e-31 108.3 16.4 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) SMAP PF15477.6 CDW54050.1 - 1.4e-11 45.1 0.3 7.3e-11 42.9 0.0 2.3 2 1 0 2 2 2 1 Small acidic protein family Glyco_transf_4 PF13439.6 CDW54051.1 - 0.024 14.6 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.6 CDW54051.1 - 0.042 13.9 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase 4-like WD40 PF00400.32 CDW54054.1 - 3.1e-06 27.8 10.3 1.2 10.1 0.0 6.4 7 1 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW54054.1 - 0.00027 21.2 0.0 0.0066 16.7 0.0 3.1 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW54054.1 - 0.021 14.7 0.0 1.1 9.1 0.0 3.0 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Malic_M PF03949.15 CDW54055.1 - 3e-100 334.7 0.2 3.8e-100 334.4 0.2 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CDW54055.1 - 8.1e-76 253.9 0.0 1.2e-75 253.3 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain TSP_1 PF00090.19 CDW54056.1 - 7.6e-05 22.8 17.9 0.00065 19.9 4.8 2.6 2 0 0 2 2 2 2 Thrombospondin type 1 domain SUR7 PF06687.12 CDW54056.1 - 0.28 10.8 2.2 19 4.8 0.1 3.0 3 0 0 3 3 3 0 SUR7/PalI family Osw5 PF17062.5 CDW54057.1 - 0.011 15.9 2.8 0.011 15.9 2.8 2.4 2 0 0 2 2 2 0 Outer spore wall 5 DUF2721 PF11026.8 CDW54057.1 - 0.16 11.9 0.1 0.16 11.9 0.1 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2721) Phage_holin_3_6 PF07332.11 CDW54057.1 - 7.5 6.6 11.2 2.6 8.1 0.7 3.1 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Toxin_30 PF08117.11 CDW54057.1 - 7.9 6.8 6.4 0.86 9.9 1.1 2.2 2 0 0 2 2 2 0 Ptu family Calx-beta PF03160.14 CDW54058.1 - 2.7e-55 184.7 3.3 1.5e-27 95.7 0.3 3.0 3 0 0 3 3 3 2 Calx-beta domain Na_Ca_ex PF01699.24 CDW54058.1 - 2.1e-52 177.1 33.6 4.7e-28 98.1 11.5 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Na_Ca_ex_C PF16494.5 CDW54058.1 - 2e-24 86.4 3.4 3.7e-24 85.6 3.4 1.4 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain Pkinase PF00069.25 CDW54059.1 - 1.3e-69 234.5 0.0 1.7e-69 234.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54059.1 - 7.2e-45 153.3 0.0 1e-44 152.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CDW54059.1 - 2.4e-13 50.2 0.1 5.4e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 CDW54059.1 - 7.3e-06 25.5 0.0 1.3e-05 24.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDW54059.1 - 0.00051 18.9 0.0 0.0012 17.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW54059.1 - 0.01 15.8 0.2 2.3 8.1 0.1 2.5 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CDW54059.1 - 0.073 12.1 0.1 0.13 11.3 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 CDW54059.1 - 0.084 12.2 0.2 0.19 11.0 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CAP PF00188.26 CDW54061.1 - 0.0021 18.9 1.1 0.0044 17.9 1.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family MIIP PF15734.5 CDW54061.1 - 0.027 14.0 4.8 0.038 13.5 4.8 1.1 1 0 0 1 1 1 0 Migration and invasion-inhibitory CAP PF00188.26 CDW54062.1 - 4.7e-06 27.5 2.1 9e-06 26.5 2.1 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family GP3_package PF16677.5 CDW54062.1 - 0.029 14.5 0.0 0.061 13.4 0.0 1.5 1 1 0 1 1 1 0 DNA-packaging protein gp3 tRNA-synt_2 PF00152.20 CDW54063.1 - 2.1e-75 253.7 0.0 3e-75 253.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDW54063.1 - 2.1e-14 53.2 0.0 4.6e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDW54063.1 - 1e-08 35.0 0.1 0.00014 21.4 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) FAD-oxidase_C PF02913.19 CDW54063.1 - 0.12 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain Cwf_Cwc_15 PF04889.12 CDW54064.1 - 1.7e-67 227.8 17.9 4.5e-67 226.4 17.9 1.6 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Alanine_zipper PF11839.8 CDW54064.1 - 0.018 15.4 6.1 0.018 15.4 6.1 2.2 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein MFAP1 PF06991.11 CDW54064.1 - 0.11 12.3 12.5 0.24 11.2 12.5 1.5 1 1 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing PP28 PF10252.9 CDW54064.1 - 0.69 10.4 12.0 6 7.4 6.4 2.6 2 0 0 2 2 2 0 Casein kinase substrate phosphoprotein PP28 Bax1-I PF01027.20 CDW54065.1 - 2.5e-36 125.5 27.1 2.8e-36 125.3 27.1 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Acetyltransf_3 PF13302.7 CDW54066.1 - 0.11 13.2 0.0 0.11 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SKA2 PF16740.5 CDW54068.1 - 0.0027 17.5 0.5 1.1 9.0 0.1 2.2 2 0 0 2 2 2 2 Spindle and kinetochore-associated protein 2 ZapB PF06005.12 CDW54068.1 - 0.0059 17.0 0.1 0.14 12.6 0.1 2.3 1 1 0 1 1 1 1 Cell division protein ZapB PID PF00640.23 CDW54070.1 - 5.5e-30 104.2 0.3 8.2e-30 103.7 0.3 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 CDW54070.1 - 2.7e-16 59.4 0.1 4.6e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 SH2 domain HECT PF00632.25 CDW54071.1 - 9.7e-54 182.9 0.0 2e-53 181.9 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) E3_UbLigase_EDD PF11547.8 CDW54071.1 - 4.2e-26 90.4 2.0 1.1e-25 89.1 2.0 1.7 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD PABP PF00658.18 CDW54071.1 - 1.3e-15 57.3 0.0 2.8e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Syndecan PF01034.20 CDW54072.1 - 2.6e-26 91.3 0.3 2.6e-26 91.3 0.3 1.8 2 1 1 3 3 3 1 Syndecan domain Glycophorin_A PF01102.18 CDW54072.1 - 0.0043 17.3 6.4 0.085 13.1 6.4 2.1 1 1 0 1 1 1 1 Glycophorin A DUF1453 PF07301.11 CDW54072.1 - 0.0045 17.0 0.9 0.0055 16.7 0.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1453) DUF4191 PF13829.6 CDW54072.1 - 0.044 13.1 0.3 0.051 12.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) VirB3 PF05101.13 CDW54072.1 - 0.048 13.9 3.8 0.048 13.9 3.8 1.4 1 1 1 2 2 2 0 Type IV secretory pathway, VirB3-like protein DUF2207 PF09972.9 CDW54072.1 - 0.073 11.8 0.3 0.08 11.7 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TraL PF07178.11 CDW54072.1 - 0.077 13.5 2.4 0.11 12.9 2.4 1.2 1 0 0 1 1 1 0 TraL protein TMEM154 PF15102.6 CDW54072.1 - 0.3 11.0 0.8 0.42 10.5 0.8 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF4118 PF13493.6 CDW54072.1 - 0.4 10.5 6.9 0.55 10.1 6.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) EphA2_TM PF14575.6 CDW54072.1 - 1.9 9.4 5.1 0.49 11.3 0.4 2.0 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain YccF PF03733.13 CDW54072.1 - 2.2 9.1 11.7 3.4 8.5 11.7 1.3 1 0 0 1 1 1 0 Inner membrane component domain HECT PF00632.25 CDW54073.1 - 5.5e-67 226.4 0.0 1e-65 222.3 0.0 2.5 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WWE PF02825.20 CDW54073.1 - 3.7e-07 30.6 0.1 9.4e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 WWE domain DUF3143 PF11341.8 CDW54073.1 - 0.054 13.8 0.4 0.22 11.9 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3143) HEAT_EZ PF13513.6 CDW54073.1 - 2.5 8.7 3.9 46 4.7 1.7 3.0 2 0 0 2 2 2 0 HEAT-like repeat RabGAP-TBC PF00566.18 CDW54074.1 - 1e-49 169.1 6.5 2.9e-41 141.5 8.3 2.7 1 1 1 2 2 2 2 Rab-GTPase-TBC domain DUF3694 PF12473.8 CDW54074.1 - 1.6e-19 71.1 0.1 1e-18 68.5 0.0 2.5 2 1 0 2 2 2 1 Kinesin protein GAS PF13851.6 CDW54074.1 - 0.00015 21.2 31.9 0.0036 16.7 11.3 3.3 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding GIT_CC PF16559.5 CDW54074.1 - 0.011 15.6 1.2 0.011 15.6 1.2 3.0 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TPR_MLP1_2 PF07926.12 CDW54074.1 - 2.7 8.1 25.5 3.7 7.6 0.4 3.7 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2203 PF09969.9 CDW54074.1 - 9.4 7.0 8.0 2.8 8.7 0.9 3.0 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) UNC45-central PF11701.8 CDW54075.1 - 1.3e-20 73.9 0.9 4e-18 65.8 0.0 4.1 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central TPR_1 PF00515.28 CDW54075.1 - 1.4e-06 27.9 9.1 0.003 17.3 0.9 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW54075.1 - 2.3e-06 27.3 14.1 0.0011 18.9 0.6 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW54075.1 - 3.8e-06 26.5 1.0 0.0018 17.9 0.4 2.7 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 CDW54075.1 - 1.9e-05 24.9 7.1 3.4e-05 24.0 2.5 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Arm PF00514.23 CDW54075.1 - 0.00043 20.2 6.6 2.4 8.3 0.0 6.1 6 1 0 6 6 5 2 Armadillo/beta-catenin-like repeat TPR_17 PF13431.6 CDW54075.1 - 0.001 19.3 2.5 0.7 10.4 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF2989 PF11207.8 CDW54075.1 - 0.0011 18.8 0.1 0.0025 17.6 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2989) Cnd3 PF12719.7 CDW54075.1 - 0.012 14.8 0.3 0.14 11.3 0.1 2.8 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain RPN7 PF10602.9 CDW54075.1 - 0.027 14.2 0.8 0.12 12.1 0.1 2.4 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_9 PF13371.6 CDW54075.1 - 0.03 14.4 6.8 0.096 12.8 0.5 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDW54075.1 - 0.031 14.9 5.8 1.9 9.2 1.8 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 CDW54075.1 - 0.031 13.5 1.7 2.7 7.1 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDW54075.1 - 0.34 10.8 8.2 29 4.7 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDW54075.1 - 0.38 11.7 6.2 4.3 8.4 0.0 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW54075.1 - 0.42 11.0 4.1 1.9 8.9 0.3 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDW54075.1 - 2.7 8.6 5.8 13 6.4 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat LIM PF00412.22 CDW54076.1 - 0.00017 21.7 5.2 0.00039 20.6 5.2 1.6 1 0 0 1 1 1 1 LIM domain SMP_LBD PF17047.5 CDW54076.1 - 0.021 14.3 0.0 0.53 9.7 0.0 2.7 3 0 0 3 3 3 0 Synaptotagmin-like mitochondrial-lipid-binding domain Transglut_core PF01841.19 CDW54076.1 - 0.095 13.2 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily CAMSAP_CKK PF08683.11 CDW54078.1 - 5.8e-47 158.7 0.1 1.3e-46 157.6 0.1 1.6 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.8 CDW54078.1 - 5.5e-28 96.6 1.8 1.2e-27 95.5 0.6 2.2 2 0 0 2 2 2 1 CAMSAP CH domain CAMSAP_CC1 PF17095.5 CDW54078.1 - 1.6e-11 43.9 4.3 1.6e-11 43.9 4.3 4.0 4 1 0 4 4 4 1 Spectrin-binding region of Ca2+-Calmodulin CH PF00307.31 CDW54078.1 - 4.1e-05 23.7 0.1 0.00014 22.0 0.0 2.0 2 0 0 2 2 2 1 Calponin homology (CH) domain COG2 PF06148.11 CDW54078.1 - 0.026 14.6 0.3 0.026 14.6 0.3 3.5 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 CDW54078.1 - 0.23 12.1 0.1 0.23 12.1 0.1 3.2 4 0 0 4 4 4 0 Initiation control protein YabA PHF5 PF03660.14 CDW54079.1 - 7.2e-50 167.5 12.9 8.1e-50 167.4 12.9 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 CDW54079.1 - 0.17 9.7 6.9 0.18 9.7 6.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Ras PF00071.22 CDW54080.1 - 3.9e-60 202.1 0.1 4.6e-60 201.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW54080.1 - 9.3e-32 109.8 0.0 1.5e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW54080.1 - 1.6e-12 47.2 0.0 2.1e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW54080.1 - 6.5e-05 23.0 0.0 0.00015 21.8 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW54080.1 - 0.00015 21.7 0.1 0.3 11.0 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 CDW54080.1 - 0.00021 20.9 0.1 0.012 15.1 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDW54080.1 - 0.0014 18.0 0.0 0.0025 17.2 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 CDW54080.1 - 0.0096 15.7 0.0 0.28 10.9 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RSF PF14876.6 CDW54080.1 - 0.013 14.5 0.1 0.018 14.0 0.1 1.1 1 0 0 1 1 1 0 Respiratory growth transcriptional regulator AAA_22 PF13401.6 CDW54080.1 - 0.025 14.8 0.2 0.77 10.0 0.0 2.4 2 1 1 3 3 3 0 AAA domain SRPRB PF09439.10 CDW54080.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 CDW54080.1 - 0.069 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Septin AAA PF00004.29 CDW54080.1 - 0.16 12.4 0.0 0.94 9.9 0.0 2.3 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sec34 PF04136.15 CDW54081.1 - 6.1e-13 48.9 4.2 2.1e-12 47.2 4.2 2.0 1 1 0 1 1 1 1 Sec34-like family UPF0203 PF05254.12 CDW54081.1 - 0.12 12.7 4.9 0.15 12.3 0.1 3.2 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0203) Actin_micro PF17003.5 CDW54082.1 - 0.002 17.4 0.2 0.002 17.4 0.2 1.6 2 0 0 2 2 2 1 Putative actin-like family zf-C2H2 PF00096.26 CDW54082.1 - 0.014 15.8 0.4 0.014 15.8 0.4 4.2 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW54082.1 - 1.6 9.8 20.1 3.9 8.6 0.4 4.1 3 0 0 3 3 3 0 C2H2-type zinc finger PQ-loop PF04193.14 CDW54084.1 - 1.6e-17 63.0 8.9 6.8e-09 35.4 0.2 3.3 3 0 0 3 3 3 2 PQ loop repeat DUF2070 PF09843.9 CDW54084.1 - 4.1 5.6 9.9 1.1 7.5 5.1 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) UCH PF00443.29 CDW54085.1 - 4.7e-28 98.4 1.8 6.3e-28 98.0 1.8 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW54085.1 - 4e-10 39.8 1.6 5.3e-10 39.4 1.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Btz PF09405.10 CDW54085.1 - 0.005 17.1 0.6 0.011 16.0 0.6 1.5 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding DEAD PF00270.29 CDW54086.1 - 5.5e-61 205.4 0.0 9.2e-61 204.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW54086.1 - 1.4e-23 83.3 0.0 3.4e-23 82.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SPRY PF00622.28 CDW54086.1 - 1.5e-12 47.7 0.1 3e-12 46.7 0.1 1.5 1 0 0 1 1 1 1 SPRY domain SH3_1 PF00018.28 CDW54087.1 - 1.5e-31 107.7 1.6 1.7e-15 56.3 0.1 3.5 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 CDW54087.1 - 3.5e-27 94.0 0.2 7.8e-15 54.5 0.0 3.3 2 1 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 CDW54087.1 - 4.8e-27 93.4 0.0 8.9e-16 57.3 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 CDW54087.1 - 1.4e-21 76.3 0.1 2.2e-21 75.7 0.1 1.3 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.11 CDW54087.1 - 0.0062 16.8 0.8 0.011 16.0 0.1 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain DUF5093 PF17011.5 CDW54087.1 - 0.037 14.3 0.0 0.059 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) Fam20C PF06702.12 CDW54089.1 - 1.1e-77 260.7 0.0 1.7e-77 260.1 0.0 1.2 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 CDW54089.1 - 7.7e-06 25.0 0.0 1.2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 FAM198 protein TRM PF02005.16 CDW54090.1 - 2.4e-93 313.3 0.2 3.1e-93 313.0 0.2 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 CDW54090.1 - 1.6e-07 31.3 0.1 3.4e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 CDW54090.1 - 0.0021 17.7 0.0 0.0032 17.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 tRNA_U5-meth_tr PF05958.11 CDW54090.1 - 0.0024 16.9 0.1 0.0037 16.3 0.1 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase LupA PF18242.1 CDW54090.1 - 0.043 13.5 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 Legionella ubiquitin-specific protease A domain PrmA PF06325.13 CDW54090.1 - 0.085 12.2 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Homeodomain PF00046.29 CDW54091.1 - 1.3e-22 79.4 5.9 2e-22 78.8 5.9 1.3 1 0 0 1 1 1 1 Homeodomain MRFAP1 PF15155.6 CDW54091.1 - 0.037 14.6 1.2 0.26 11.8 0.3 1.9 1 1 1 2 2 2 0 MORF4 family-associated protein1 QLQ PF08880.11 CDW54091.1 - 0.04 13.7 0.1 0.061 13.1 0.1 1.3 1 0 0 1 1 1 0 QLQ Polyketide_cyc PF03364.20 CDW54091.1 - 0.048 13.9 0.4 0.06 13.6 0.4 1.1 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Homeobox_KN PF05920.11 CDW54091.1 - 0.094 12.6 1.0 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 Homeobox KN domain DFRP_C PF16543.5 CDW54091.1 - 0.36 11.4 15.8 0.99 9.9 0.5 2.4 1 1 1 2 2 2 0 DRG Family Regulatory Proteins, Tma46 UNC-93 PF05978.16 CDW54092.1 - 1.3e-09 38.0 7.6 1.3e-09 38.0 7.6 2.8 2 1 1 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 CDW54092.1 - 0.00065 18.7 46.3 0.0035 16.3 10.4 4.5 1 1 1 3 3 3 2 Major Facilitator Superfamily zf-ZPR1 PF03367.13 CDW54093.1 - 1.1e-100 334.1 2.5 1.3e-51 174.6 0.1 2.8 2 1 0 2 2 2 2 ZPR1 zinc-finger domain HTH_12 PF08461.10 CDW54093.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain CpXC PF14353.6 CDW54093.1 - 0.14 12.2 5.1 16 5.6 0.1 3.6 2 2 1 3 3 3 0 CpXC protein zf-LITAF-like PF10601.9 CDW54093.1 - 0.44 10.8 8.3 7.3 6.9 3.1 3.4 3 1 0 3 3 3 0 LITAF-like zinc ribbon domain UPF0547 PF10571.9 CDW54093.1 - 5.6 7.1 8.1 2.6 8.2 0.5 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 OrfB_Zn_ribbon PF07282.11 CDW54093.1 - 6.2 6.8 9.5 11 6.1 0.0 3.6 3 1 1 4 4 4 0 Putative transposase DNA-binding domain HypA PF01155.19 CDW54093.1 - 6.3 6.9 10.1 3.7 7.6 1.2 2.9 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA AAA PF00004.29 CDW54094.1 - 8.7e-58 194.4 1.5 2.9e-45 153.9 0.0 3.0 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW54094.1 - 6.8e-16 57.8 1.0 1.5e-11 43.9 0.4 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 CDW54094.1 - 9.6e-12 44.9 0.0 4.2e-05 23.4 0.0 3.1 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDW54094.1 - 2.4e-09 37.3 0.5 0.0068 16.4 0.0 4.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW54094.1 - 5.4e-09 36.7 1.3 0.004 17.5 0.1 4.1 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 CDW54094.1 - 2.6e-08 33.5 0.0 0.0009 18.5 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 CDW54094.1 - 6.3e-07 29.6 0.0 0.012 15.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 CDW54094.1 - 1.8e-06 28.0 0.1 0.054 13.4 0.0 2.8 2 2 0 2 2 2 2 Rad17 P-loop domain AAA_2 PF07724.14 CDW54094.1 - 2e-06 28.0 0.0 0.003 17.7 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 CDW54094.1 - 4.2e-06 26.3 0.1 0.032 13.6 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 CDW54094.1 - 4.6e-06 26.4 0.4 0.096 12.3 0.0 3.4 2 1 1 3 3 3 1 AAA domain RNA_helicase PF00910.22 CDW54094.1 - 5.8e-06 26.6 0.0 0.06 13.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 CDW54094.1 - 2.3e-05 24.4 0.9 1.7 8.5 0.0 4.2 4 0 0 4 4 4 1 NACHT domain IstB_IS21 PF01695.17 CDW54094.1 - 4.1e-05 23.4 0.0 0.24 11.1 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 CDW54094.1 - 4.5e-05 23.8 3.6 0.56 10.5 0.1 4.6 2 2 1 3 3 3 1 AAA domain AAA_28 PF13521.6 CDW54094.1 - 0.00012 22.4 0.0 0.37 11.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 CDW54094.1 - 0.00029 20.9 0.0 1.3 9.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CDW54094.1 - 0.00057 20.4 0.0 0.34 11.5 0.0 2.9 3 0 0 3 3 2 1 AAA domain Sigma54_activ_2 PF14532.6 CDW54094.1 - 0.001 19.2 0.0 2.7 8.1 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain Zeta_toxin PF06414.12 CDW54094.1 - 0.0023 17.3 0.0 2.7 7.2 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin Viral_helicase1 PF01443.18 CDW54094.1 - 0.0026 17.5 0.0 0.23 11.2 0.1 2.6 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 CDW54094.1 - 0.0028 17.6 0.3 0.92 9.4 0.0 3.4 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CDW54094.1 - 0.0034 17.9 0.0 0.35 11.4 0.0 2.7 3 0 0 3 3 2 1 ABC transporter AAA_3 PF07726.11 CDW54094.1 - 0.0054 16.6 0.2 0.071 13.0 0.0 2.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CDW54094.1 - 0.0057 15.8 0.0 1.2 8.2 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 CDW54094.1 - 0.0065 15.7 0.0 0.34 10.1 0.0 3.1 3 1 0 4 4 4 1 NB-ARC domain Parvo_NS1 PF01057.17 CDW54094.1 - 0.0084 15.2 0.0 1.2 8.2 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 CDW54094.1 - 0.0087 15.6 0.0 5.2 6.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region RsdA_SigD_bd PF16751.5 CDW54094.1 - 0.0089 16.3 2.7 3.8 7.9 0.2 2.7 2 0 0 2 2 2 2 Anti-sigma-D factor RsdA to sigma factor binding region AAA_24 PF13479.6 CDW54094.1 - 0.012 15.4 0.0 0.38 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CDW54094.1 - 0.013 15.9 0.0 2.1 8.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 CDW54094.1 - 0.016 15.0 0.1 6.1 6.5 0.0 2.5 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 CDW54094.1 - 0.03 14.3 0.1 13 5.8 0.0 2.6 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DNA_pol3_delta2 PF13177.6 CDW54094.1 - 0.048 13.4 0.0 25 4.6 0.1 3.1 2 1 1 3 3 3 0 DNA polymerase III, delta subunit ATPase PF06745.13 CDW54094.1 - 0.064 12.6 0.0 10 5.4 0.0 2.8 3 0 0 3 3 3 0 KaiC Sigma54_activat PF00158.26 CDW54094.1 - 0.077 12.7 0.0 24 4.6 0.0 3.3 2 2 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 CDW54094.1 - 0.083 12.3 0.0 4.7 6.6 0.0 2.6 3 0 0 3 3 2 0 PhoH-like protein NTPase_1 PF03266.15 CDW54094.1 - 0.14 12.0 2.4 15 5.5 0.3 3.2 2 2 2 4 4 4 0 NTPase Peptidase_C92 PF05708.12 CDW54095.1 - 1.8e-12 47.6 0.1 2.1e-12 47.4 0.1 1.1 1 0 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Exo70 PF03081.15 CDW54096.1 - 1.8e-57 195.1 7.2 1.8e-57 195.1 7.2 1.9 2 0 0 2 2 2 1 Exo70 exocyst complex subunit SAT PF16073.5 CDW54096.1 - 0.094 12.4 0.7 3.1 7.5 0.1 2.5 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis UDPGT PF00201.18 CDW54097.1 - 2.9e-44 151.7 0.3 4.2e-44 151.2 0.2 1.2 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase COX6B PF02297.17 CDW54098.1 - 7.9e-12 45.2 5.8 7.9e-12 45.2 5.8 1.6 2 0 0 2 2 2 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 CDW54098.1 - 0.029 14.4 2.2 0.031 14.3 1.0 1.6 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, RMF PF04957.12 CDW54098.1 - 0.068 13.4 1.2 9.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Ribosome modulation factor Tudor-knot PF11717.8 CDW54098.1 - 0.77 9.7 4.8 6.8 6.7 0.5 2.5 2 1 0 2 2 2 0 RNA binding activity-knot of a chromodomain CRAL_TRIO PF00650.20 CDW54099.1 - 2.3e-20 72.9 0.0 4.1e-20 72.1 0.0 1.4 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDW54099.1 - 0.028 14.6 0.1 0.062 13.4 0.1 1.6 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain Dor1 PF04124.12 CDW54099.1 - 0.14 10.8 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 Dor1-like family UPRTase PF14681.6 CDW54100.1 - 1.1e-48 165.5 0.0 1.3e-48 165.2 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CDW54100.1 - 0.002 17.7 0.1 0.0025 17.3 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DNA_pol_A PF00476.20 CDW54101.1 - 2.4e-70 237.5 0.0 1.6e-49 169.0 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase family A DEAD PF00270.29 CDW54101.1 - 3.2e-14 53.1 0.0 6.5e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW54101.1 - 2.2e-11 44.1 0.0 2.2e-08 34.4 0.0 2.8 1 1 1 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 CDW54101.1 - 2e-06 27.9 0.0 3.7e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit MOZ_SAS PF01853.18 CDW54102.1 - 6.9e-51 172.4 0.1 9.8e-51 171.9 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family DUF2586 PF10758.9 CDW54102.1 - 0.34 10.1 2.5 0.46 9.6 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2586) EF1_GNE PF00736.19 CDW54103.1 - 1.2e-36 124.8 2.1 2.9e-36 123.5 2.1 1.7 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 CDW54103.1 - 0.00032 21.1 17.0 0.00032 21.1 17.0 2.9 2 1 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region DUF3752 PF12572.8 CDW54103.1 - 0.0014 19.1 0.9 0.0019 18.7 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3752) Pol_alpha_B_N PF08418.10 CDW54103.1 - 0.067 13.1 3.0 0.3 11.0 0.2 2.0 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Biotin_lipoyl PF00364.22 CDW54103.1 - 0.094 12.6 2.1 0.17 11.8 0.2 2.1 2 0 0 2 2 2 0 Biotin-requiring enzyme Cwf_Cwc_15 PF04889.12 CDW54103.1 - 0.1 12.3 3.1 0.12 12.1 3.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Fes1 PF08609.10 CDW54103.1 - 0.97 10.4 4.6 0.69 10.8 0.3 2.6 2 1 1 3 3 3 0 Nucleotide exchange factor Fes1 Mito_carr PF00153.27 CDW54104.1 - 1.7e-32 111.2 0.1 7.4e-11 41.8 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF953 PF06110.11 CDW54105.1 - 2.4e-23 82.0 0.0 2.9e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) rpo132 PF12415.8 CDW54105.1 - 0.044 13.1 0.2 0.068 12.5 0.2 1.3 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase DUF872 PF05915.12 CDW54105.1 - 0.058 13.6 0.7 0.12 12.6 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) zf-MYND PF01753.18 CDW54106.1 - 0.0011 19.0 12.8 0.0011 19.0 12.8 2.2 2 0 0 2 2 2 1 MYND finger ACTL7A_N PF16840.5 CDW54106.1 - 0.21 11.7 1.7 22 5.2 0.0 3.5 3 0 0 3 3 3 0 Actin-like protein 7A N-terminus zinc_ribbon_4 PF13717.6 CDW54106.1 - 1.5 8.8 7.9 1.6 8.7 1.6 3.4 3 0 0 3 3 3 0 zinc-ribbon domain EGF PF00008.27 CDW54107.1 - 2.3e-10 40.6 29.3 1.4e-05 25.3 7.1 3.9 4 0 0 4 4 4 3 EGF-like domain EGF_2 PF07974.13 CDW54107.1 - 1.9e-09 37.7 39.4 0.00075 19.8 10.0 3.6 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 CDW54107.1 - 3.2e-08 33.9 22.6 0.00073 20.1 1.8 5.3 4 0 0 4 4 4 3 Human growth factor-like EGF EGF_3 PF12947.7 CDW54107.1 - 0.0034 17.5 31.6 0.0096 16.1 5.8 4.3 1 1 1 3 3 3 2 EGF domain FXa_inhibition PF14670.6 CDW54107.1 - 0.39 11.0 31.7 7.6 6.9 2.8 3.7 2 1 1 3 3 3 0 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 CDW54107.1 - 0.88 9.8 36.6 1.9 8.7 7.1 3.8 1 1 2 3 3 3 0 Laminin EGF domain EGF_CA PF07645.15 CDW54107.1 - 1.1 9.5 39.4 0.49 10.6 11.5 3.7 1 1 2 3 3 3 0 Calcium-binding EGF domain EGF_MSP1_1 PF12946.7 CDW54107.1 - 8.8 6.5 28.7 0.36 10.9 6.3 3.5 3 0 0 3 3 3 0 MSP1 EGF domain 1 EGF PF00008.27 CDW54108.1 - 3.4e-09 36.8 32.3 0.00086 19.6 9.0 4.1 3 0 0 3 3 3 3 EGF-like domain EGF_2 PF07974.13 CDW54108.1 - 0.00013 22.2 44.9 0.035 14.5 10.6 4.2 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 CDW54108.1 - 0.0028 18.2 35.9 0.011 16.3 3.8 5.5 6 0 0 6 6 6 3 Human growth factor-like EGF EGF_3 PF12947.7 CDW54108.1 - 2.4 8.4 32.7 5.7 7.2 6.6 4.1 2 1 1 3 3 3 0 EGF domain Tim17 PF02466.19 CDW54109.1 - 1.4e-30 105.9 6.8 1.7e-30 105.7 6.8 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Bacteriocin_IIc PF10439.9 CDW54109.1 - 4 7.6 10.0 18 5.5 6.1 2.2 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide Romo1 PF10247.9 CDW54109.1 - 6.2 7.3 14.8 2.3 8.6 3.9 3.1 2 2 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 zf-CDGSH PF09360.10 CDW54110.1 - 7.5e-11 42.1 0.8 1.5e-10 41.1 0.8 1.6 1 1 0 1 1 1 1 Iron-binding zinc finger CDGSH type Sushi PF00084.20 CDW54111.1 - 6.4e-101 330.9 73.1 4.3e-10 40.0 2.2 15.0 15 0 0 15 15 15 13 Sushi repeat (SCR repeat) HRM PF02793.22 CDW54111.1 - 8.5e-05 22.8 43.7 0.0092 16.3 0.4 9.7 8 1 1 9 9 9 5 Hormone receptor domain Glypican PF01153.19 CDW54112.1 - 3.4e-119 399.2 0.1 4.8e-119 398.7 0.1 1.2 1 0 0 1 1 1 1 Glypican Fz PF01392.22 CDW54112.1 - 0.0023 18.5 0.6 0.0065 17.1 0.6 1.7 1 0 0 1 1 1 1 Fz domain 2Fe-2S_thioredx PF01257.19 CDW54113.1 - 1.5e-62 209.8 0.2 1.7e-62 209.6 0.2 1.0 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Cpn60_TCP1 PF00118.24 CDW54114.1 - 1.8e-156 521.6 8.5 2.1e-156 521.4 8.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EMP70 PF02990.16 CDW54115.1 - 3.9e-193 642.9 16.5 3.9e-193 642.9 16.5 1.3 2 0 0 2 2 2 1 Endomembrane protein 70 IER PF05760.12 CDW54116.1 - 2.3e-05 24.9 4.2 0.00019 21.9 4.3 2.0 1 1 0 1 1 1 1 Immediate early response protein (IER) Acetyltransf_2 PF00797.17 CDW54116.1 - 0.1 12.4 0.6 0.23 11.2 0.0 1.7 2 0 0 2 2 2 0 N-acetyltransferase Rad9 PF04139.13 CDW54117.1 - 2.2e-54 184.5 0.0 3e-54 184.1 0.0 1.2 1 0 0 1 1 1 1 Rad9 Gln-synt_C PF00120.24 CDW54118.1 - 4.2e-16 58.9 0.0 6.1e-15 55.1 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CDW54118.1 - 1.8e-12 46.8 0.0 3.7e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Peptidase_M55 PF04951.13 CDW54118.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 D-aminopeptidase Fe-S_biosyn PF01521.20 CDW54119.1 - 7.8e-21 74.4 0.0 9.2e-21 74.1 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis STT3 PF02516.14 CDW54120.1 - 3.7e-146 487.9 45.2 1.5e-141 472.7 38.8 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Piwi PF02171.17 CDW54120.1 - 5.4e-107 357.5 0.0 1.4e-106 356.1 0.0 1.7 2 0 0 2 2 2 1 Piwi domain ArgoMid PF16487.5 CDW54120.1 - 1.1e-32 112.1 0.1 3.1e-32 110.7 0.1 1.8 1 0 0 1 1 1 1 Mid domain of argonaute ArgoN PF16486.5 CDW54120.1 - 1.3e-29 103.6 0.0 2.5e-29 102.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CDW54120.1 - 2.1e-23 81.7 0.1 4.9e-23 80.6 0.1 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 CDW54120.1 - 4.3e-21 75.2 0.2 1e-20 73.9 0.2 1.6 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 CDW54120.1 - 6.5e-12 45.6 0.0 1.3e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain PMT_2 PF13231.6 CDW54120.1 - 1.6e-06 28.5 12.7 1.6e-06 28.5 12.7 2.7 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase ANAPC4_WD40 PF12894.7 CDW54121.1 - 7.3e-16 58.3 0.8 9.1e-05 22.7 0.0 5.1 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDW54121.1 - 4.6e-14 52.6 24.2 8e-06 26.5 0.5 7.2 7 1 1 8 8 8 4 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 CDW54121.1 - 1e-06 28.1 0.7 0.006 15.7 0.1 2.6 2 0 0 2 2 2 2 Coatomer WD associated region PD40 PF07676.12 CDW54121.1 - 2.2e-06 27.5 1.4 0.0091 15.9 0.0 4.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 CDW54121.1 - 0.00017 20.5 0.3 0.15 10.8 0.0 3.1 1 1 1 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region IKI3 PF04762.12 CDW54121.1 - 0.00019 19.6 0.1 0.27 9.2 0.0 3.1 2 1 1 3 3 3 2 IKI3 family Ge1_WD40 PF16529.5 CDW54121.1 - 0.0026 16.8 0.2 0.34 9.8 0.0 2.9 1 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein TFIIIC_delta PF12657.7 CDW54121.1 - 0.012 15.5 2.7 0.58 10.1 2.6 3.0 1 1 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Frtz PF11768.8 CDW54121.1 - 0.013 13.9 0.1 1.5 7.1 0.0 3.5 4 0 0 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz Clathrin PF00637.20 CDW54121.1 - 0.031 14.2 3.6 0.11 12.3 1.0 2.5 1 1 0 2 2 2 0 Region in Clathrin and VPS LRR_8 PF13855.6 CDW54122.1 - 4.9e-18 64.6 7.9 1.4e-07 31.2 0.1 4.0 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 CDW54122.1 - 7.1e-14 51.7 10.5 4.6e-06 26.9 0.1 4.9 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDW54122.1 - 2.2e-06 27.4 16.8 4.6 8.2 0.0 7.8 8 0 0 8 8 8 4 Leucine Rich Repeat LRR_6 PF13516.6 CDW54122.1 - 1.1e-05 25.0 10.0 0.5 10.6 0.1 5.9 5 0 0 5 5 5 2 Leucine Rich repeat LRR_9 PF14580.6 CDW54122.1 - 0.0002 20.9 0.9 0.00028 20.4 0.2 1.5 2 0 0 2 2 2 1 Leucine-rich repeat DUF3580 PF12117.8 CDW54122.1 - 0.14 12.4 0.2 0.45 10.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3580) CH PF00307.31 CDW54123.1 - 2.7e-09 37.2 0.0 3.3e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 CDW54123.1 - 0.035 13.9 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain Peptidase_C2 PF00648.21 CDW54124.1 - 5.8e-108 360.4 0.3 1.1e-107 359.5 0.3 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 CDW54124.1 - 1.8e-24 86.6 0.0 3.1e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III C2 PF00168.30 CDW54124.1 - 9.1e-11 42.0 0.0 2.3e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 C2 domain Adaptin_N PF01602.20 CDW54125.1 - 3.5e-90 303.1 11.9 5.2e-90 302.5 11.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 CDW54125.1 - 2.7e-56 189.0 0.0 5.5e-56 188.0 0.0 1.5 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 CDW54125.1 - 2.6e-50 170.0 0.2 6.4e-50 168.7 0.2 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 CDW54125.1 - 1.5e-09 38.1 0.9 0.031 14.7 0.0 4.9 2 2 2 4 4 4 2 HEAT repeats Cnd1 PF12717.7 CDW54125.1 - 3.6e-08 33.6 7.0 6.6e-05 23.0 0.0 3.5 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Coatomer_g_Cpla PF16381.5 CDW54125.1 - 5.8e-05 23.2 0.8 0.00028 21.0 0.0 2.5 3 0 0 3 3 3 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 CDW54125.1 - 8.2e-05 22.5 0.2 2.4 8.6 0.0 4.9 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 CDW54125.1 - 0.0069 16.9 2.0 13 6.5 0.0 4.9 4 0 0 4 4 4 1 HEAT-like repeat Bac_RepA_C PF18008.1 CDW54125.1 - 0.089 13.2 0.1 0.55 10.6 0.0 2.3 2 0 0 2 2 2 0 Replication initiator protein A C-terminal domain Biotin_lipoyl PF00364.22 CDW54125.1 - 0.096 12.5 0.0 15 5.5 0.0 2.5 2 0 0 2 2 2 0 Biotin-requiring enzyme DUF5578 PF17741.1 CDW54125.1 - 0.1 12.0 8.6 4 6.8 0.3 3.6 3 1 1 4 4 4 0 Family of unknown function (DUF5578) SPG48 PF14764.6 CDW54125.1 - 1.3 9.5 4.1 51 4.4 0.2 3.9 1 1 2 3 3 3 0 AP-5 complex subunit, vesicle trafficking TPR_1 PF00515.28 CDW54126.1 - 2.9e-27 93.3 1.3 6.5e-06 25.7 0.0 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 CDW54126.1 - 1.3e-22 78.0 0.3 0.00074 19.4 0.0 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 CDW54126.1 - 5.4e-19 68.5 3.9 3.1e-05 24.4 0.1 4.7 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDW54126.1 - 1.5e-18 65.9 6.9 0.0017 19.0 0.1 7.1 5 2 3 8 8 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDW54126.1 - 2.8e-18 66.3 0.4 3.5e-08 34.0 0.5 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDW54126.1 - 2.9e-18 64.5 0.3 0.014 15.5 0.0 7.4 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDW54126.1 - 4.8e-18 64.5 3.7 3.4e-08 33.0 0.4 4.8 4 1 1 5 5 4 3 TPR repeat DnaJ PF00226.31 CDW54126.1 - 1.1e-16 60.6 5.5 6e-16 58.3 5.2 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_17 PF13431.6 CDW54126.1 - 2.8e-15 55.5 8.5 5.4e-05 23.3 0.5 6.4 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 CDW54126.1 - 5.5e-15 55.3 1.0 0.0001 22.4 0.1 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 CDW54126.1 - 2.9e-11 43.2 3.6 4.5 8.1 0.0 7.2 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDW54126.1 - 1.7e-10 41.0 0.4 0.0018 18.6 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW54126.1 - 8.8e-08 32.3 0.0 0.00062 19.9 0.0 3.5 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CDW54126.1 - 6.4e-05 22.7 1.1 5.3 7.3 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_20 PF14561.6 CDW54126.1 - 8e-05 22.9 2.3 0.097 13.0 0.2 4.0 3 2 2 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDW54126.1 - 0.00098 18.4 0.4 1.8 7.7 0.0 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_21 PF09976.9 CDW54126.1 - 0.012 15.3 1.5 0.017 14.9 0.2 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_4 PF07721.14 CDW54126.1 - 0.014 16.0 3.9 1 10.1 0.3 4.2 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW54126.1 - 0.024 14.0 0.1 0.87 8.9 0.0 3.0 3 1 1 4 4 4 0 MalT-like TPR region TPR_10 PF13374.6 CDW54126.1 - 0.054 13.4 1.5 3.8 7.5 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat FAT PF02259.23 CDW54126.1 - 0.11 11.7 0.2 2.6 7.2 0.0 2.7 4 0 0 4 4 4 0 FAT domain Ctf8 PF09696.10 CDW54127.1 - 9e-06 26.1 0.4 0.00021 21.6 0.1 2.5 1 1 1 2 2 2 1 Ctf8 zf_C2H2_6 PF18450.1 CDW54128.1 - 0.016 14.9 3.4 4.6 7.0 0.1 3.3 2 0 0 2 2 2 0 Zinc Finger domain zf-C2H2 PF00096.26 CDW54128.1 - 0.58 10.7 12.7 1.6 9.4 0.8 3.7 3 1 0 3 3 3 0 Zinc finger, C2H2 type zf-HIT PF04438.16 CDW54128.1 - 0.65 9.9 5.3 15 5.5 0.1 3.5 3 0 0 3 3 3 0 HIT zinc finger zf-C2H2_4 PF13894.6 CDW54128.1 - 0.75 10.8 16.8 0.98 10.4 0.5 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger MRP-S35 PF10246.9 CDW54129.1 - 1.5e-44 150.2 0.1 3.9e-44 148.9 0.0 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein MRP-S35 Mesd PF10185.9 CDW54129.1 - 1.1e-37 129.4 4.4 1.5e-37 128.9 4.4 1.1 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor TIL PF01826.17 CDW54130.1 - 8.7e-11 41.9 13.5 8.7e-11 41.9 13.5 3.0 2 1 0 2 2 2 1 Trypsin Inhibitor like cysteine rich domain WAP PF00095.21 CDW54130.1 - 1.4e-09 38.2 6.0 1.4e-09 38.2 6.0 4.3 3 1 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Acyl_transf_3 PF01757.22 CDW54132.1 - 1.3e-22 80.4 47.2 1.3e-22 80.4 47.2 1.8 2 0 0 2 2 2 1 Acyltransferase family Orf78 PF06024.12 CDW54132.1 - 0.29 11.4 0.1 0.29 11.4 0.1 2.2 3 0 0 3 3 3 0 Orf78 (ac78) Pinin_SDK_memA PF04696.13 CDW54133.1 - 1.6e-21 76.8 10.7 1.6e-21 76.8 10.7 2.7 4 0 0 4 4 4 1 pinin/SDK/memA/ protein conserved region Sec1 PF00995.23 CDW54134.1 - 2.1e-118 397.1 0.0 2.4e-118 396.9 0.0 1.0 1 0 0 1 1 1 1 Sec1 family TFR_dimer PF04253.15 CDW54134.1 - 0.14 12.2 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Transferrin receptor-like dimerisation domain Myb_DNA-binding PF00249.31 CDW54135.1 - 0.0072 16.5 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain ELM2 PF01448.24 CDW54135.1 - 0.059 14.1 0.0 0.12 13.1 0.0 1.5 1 0 0 1 1 1 0 ELM2 domain DUF4114 PF13448.6 CDW54135.1 - 0.095 13.5 0.0 0.25 12.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4114) Tetraspanin PF00335.20 CDW54136.1 - 8.1e-26 91.1 4.4 9.5e-26 90.9 4.4 1.0 1 0 0 1 1 1 1 Tetraspanin family CRPA PF05745.11 CDW54136.1 - 0.068 13.2 1.1 0.34 10.9 1.2 2.0 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Ninjurin PF04923.12 CDW54136.1 - 0.083 12.8 1.3 0.17 11.9 1.3 1.6 1 0 0 1 1 1 0 Ninjurin DUF2985 PF11204.8 CDW54136.1 - 0.19 11.9 0.2 0.19 11.9 0.2 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2985) DUF2981 PF11200.8 CDW54136.1 - 3.9 7.1 5.6 4.4 7.0 5.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2981) ADH_zinc_N PF00107.26 CDW54137.1 - 8.9e-09 35.4 0.0 1.5e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW54137.1 - 9.7e-08 31.9 0.0 2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain RNA_pol_Rpb4 PF03874.16 CDW54138.1 - 4.2e-21 75.5 2.8 6.2e-21 75.0 2.8 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 SART-1 PF03343.13 CDW54139.1 - 1.4e-87 294.7 26.8 9e-82 275.6 20.2 2.1 2 0 0 2 2 2 2 SART-1 family UPF0227 PF05728.12 CDW54139.1 - 0.17 11.8 0.0 0.17 11.8 0.0 2.2 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0227) Cpn60_TCP1 PF00118.24 CDW54140.1 - 1.1e-155 519.0 8.4 1.3e-155 518.8 8.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TPR_1 PF00515.28 CDW54141.1 - 0.00066 19.4 1.5 0.02 14.7 0.6 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW54141.1 - 0.0019 18.2 7.9 0.0093 16.0 0.8 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat ADIP PF11559.8 CDW54141.1 - 0.0023 18.0 4.6 0.0023 18.0 4.6 2.3 2 1 0 2 2 2 1 Afadin- and alpha -actinin-Binding FapA PF03961.13 CDW54141.1 - 0.016 13.8 3.5 0.026 13.2 3.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A TPR_12 PF13424.6 CDW54141.1 - 0.084 13.2 6.4 2.8 8.3 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat SLATT_5 PF18160.1 CDW54141.1 - 0.15 11.4 2.6 0.28 10.5 2.6 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 SLATT_6 PF18169.1 CDW54141.1 - 0.22 11.1 1.0 0.44 10.1 1.0 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 TPR_8 PF13181.6 CDW54141.1 - 0.24 11.7 3.7 0.45 10.9 0.6 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat EMC3_TMCO1 PF01956.16 CDW54141.1 - 1.2 8.8 4.9 0.15 11.8 0.7 1.6 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Fez1 PF06818.15 CDW54141.1 - 2.7 8.4 16.7 0.45 10.9 7.0 2.3 2 0 0 2 2 2 0 Fez1 ATP-synt_B PF00430.18 CDW54141.1 - 3.5 7.7 14.6 0.07 13.2 7.0 2.1 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Sterol-sensing PF12349.8 CDW54142.1 - 9.1e-38 129.5 3.8 9.1e-38 129.5 3.8 2.0 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CDW54142.1 - 1.9e-09 36.3 10.6 3e-09 35.6 10.6 1.2 1 0 0 1 1 1 1 Patched family WD40 PF00400.32 CDW54142.1 - 0.0025 18.6 6.1 0.34 11.9 0.1 4.9 4 0 0 4 4 4 1 WD domain, G-beta repeat Asp_Arg_Hydrox PF05118.15 CDW54143.1 - 4.5e-30 104.6 0.0 1.1e-29 103.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase TPR_16 PF13432.6 CDW54143.1 - 3.9e-09 37.0 4.0 0.097 13.3 0.0 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDW54143.1 - 1.6e-07 31.7 0.4 0.0013 19.2 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW54143.1 - 2.3e-06 27.6 1.1 0.14 12.6 0.0 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDW54143.1 - 5e-06 26.7 4.6 0.023 15.0 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW54143.1 - 6.6e-06 26.5 2.3 2.7 9.0 0.0 4.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW54143.1 - 1.3e-05 24.9 6.5 0.04 14.0 0.2 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat Coatomer_E PF04733.14 CDW54143.1 - 0.0026 17.2 0.0 0.0053 16.2 0.0 1.4 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_1 PF00515.28 CDW54143.1 - 0.031 14.1 1.2 0.72 9.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDW54143.1 - 0.093 13.4 2.1 31 5.5 0.1 4.7 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDW54143.1 - 0.13 12.2 3.9 22 5.1 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW54143.1 - 0.19 12.0 0.3 2.7 8.4 0.0 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDW54143.1 - 0.51 10.1 6.0 1.8 8.3 0.4 3.5 3 0 0 3 3 3 0 TPR repeat PI3K_1B_p101 PF10486.9 CDW54143.1 - 4 5.1 10.5 6.5 4.4 10.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Prenyltransf PF01255.19 CDW54144.1 - 6.9e-47 159.8 2.3 3.2e-26 92.3 0.2 2.1 1 1 1 2 2 2 2 Putative undecaprenyl diphosphate synthase Imm41 PF15592.6 CDW54144.1 - 0.046 14.1 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 41 Oxysterol_BP PF01237.18 CDW54145.1 - 7e-115 383.8 0.0 8e-115 383.6 0.0 1.0 1 0 0 1 1 1 1 Oxysterol-binding protein Peptidase_M3 PF01432.20 CDW54146.1 - 1.5e-80 271.7 0.0 2e-80 271.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Spot_14 PF07084.12 CDW54147.1 - 5.8e-24 85.0 1.3 5.8e-23 81.7 1.3 2.0 1 1 0 1 1 1 1 Thyroid hormone-inducible hepatic protein Spot 14 Tetraspanin PF00335.20 CDW54148.1 - 2.2e-15 57.0 3.1 4.1e-15 56.1 3.1 1.4 1 0 0 1 1 1 1 Tetraspanin family DUF4006 PF13179.6 CDW54148.1 - 0.25 11.3 3.8 0.11 12.5 0.5 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF4006) adh_short PF00106.25 CDW54149.1 - 6.4e-49 166.1 6.4 8.1e-49 165.7 6.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW54149.1 - 7e-47 159.9 11.1 3.4e-45 154.4 11.1 2.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW54149.1 - 8.6e-08 32.3 3.7 2.5e-05 24.3 1.5 2.2 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 CDW54149.1 - 0.01 15.3 2.4 0.039 13.4 2.4 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DFP PF04127.15 CDW54149.1 - 0.57 10.0 4.5 3.4 7.5 4.5 2.2 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein adh_short_C2 PF13561.6 CDW54150.1 - 2.8e-28 99.0 12.0 3.8e-17 62.6 3.7 3.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDW54150.1 - 8e-25 87.4 11.5 6.3e-21 74.7 11.5 3.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDW54150.1 - 3.5e-06 27.0 3.5 4e-05 23.6 3.5 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CDW54150.1 - 0.056 12.9 0.7 0.12 11.8 0.5 1.6 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 CDW54151.1 - 6.1e-46 156.9 11.6 2.8e-44 151.4 11.6 2.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDW54151.1 - 4.5e-45 153.5 4.2 6.2e-45 153.1 4.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDW54151.1 - 5.7e-07 29.6 3.6 8.7e-07 29.0 0.7 2.3 2 1 0 2 2 2 1 KR domain Cas_Cas02710 PF09670.10 CDW54151.1 - 0.048 12.5 0.3 0.45 9.3 0.0 2.4 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas02710) Recep_L_domain PF01030.24 CDW54152.1 - 3.5e-47 159.2 0.6 1.7e-24 86.0 0.0 2.9 3 0 0 3 3 3 2 Receptor L domain GF_recep_IV PF14843.6 CDW54152.1 - 8.1e-29 100.1 118.0 1.2e-19 70.4 30.6 6.0 2 2 3 6 6 6 5 Growth factor receptor domain IV Furin-like PF00757.20 CDW54152.1 - 9.4e-26 90.5 119.8 2.1e-23 82.8 38.4 5.7 2 1 2 4 4 4 3 Furin-like cysteine rich region DUF3377 PF11857.8 CDW54152.1 - 0.049 13.5 0.4 0.1 12.5 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Neur_chan_LBD PF02931.23 CDW54153.1 - 2.7e-77 259.1 0.9 4e-77 258.5 0.9 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW54153.1 - 1.1e-67 228.6 5.4 1.9e-67 227.8 5.4 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Antimicrobial_6 PF08036.11 CDW54153.1 - 0.15 12.2 0.6 0.28 11.3 0.6 1.4 1 0 0 1 1 1 0 Diapausin family of antimicrobial peptide Peptidase_M28 PF04389.17 CDW54154.1 - 4.1e-35 121.3 0.0 6.1e-35 120.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CDW54154.1 - 0.0035 17.1 0.0 0.021 14.5 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 Baculo_LEF5_C PF11792.8 CDW54155.1 - 0.07 12.8 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain Adeno_E3_CR2 PF02439.15 CDW54155.1 - 0.15 11.9 6.9 0.29 10.9 6.9 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Patched PF02460.18 CDW54157.1 - 5e-161 537.6 13.0 6.2e-161 537.3 13.0 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW54157.1 - 9.5e-35 119.7 11.6 2.5e-34 118.3 4.7 2.5 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 CDW54157.1 - 0.00024 20.2 2.6 0.00024 20.2 2.6 1.7 2 0 0 2 2 2 1 MMPL family zf-C4H2 PF10146.9 CDW54158.1 - 7e-48 163.8 2.2 8.9e-48 163.4 2.2 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein zf-C3HC4_3 PF13920.6 CDW54158.1 - 0.0034 17.2 2.7 0.0065 16.3 2.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 CDW54158.1 - 0.014 15.4 1.1 0.028 14.5 1.1 1.5 1 0 0 1 1 1 0 Double zinc ribbon 2-oxoacid_dh PF00198.23 CDW54159.1 - 1.3e-66 224.4 0.0 2.5e-66 223.4 0.0 1.4 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CDW54159.1 - 1.6e-17 63.1 0.1 3.8e-17 61.9 0.1 1.6 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 CDW54159.1 - 3.9e-16 59.1 0.1 8e-16 58.1 0.1 1.6 1 0 0 1 1 1 1 e3 binding domain HlyD_D23 PF16576.5 CDW54159.1 - 0.00051 19.3 0.2 0.00087 18.6 0.2 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 CDW54159.1 - 0.1 12.4 0.6 0.93 9.4 0.1 2.4 1 1 1 2 2 2 0 Biotin-lipoyl like c-SKI_SMAD_bind PF08782.10 CDW54160.1 - 1.5e-25 89.2 3.2 3.1e-25 88.2 3.2 1.5 1 0 0 1 1 1 1 c-SKI Smad4 binding domain Ski_Sno PF02437.17 CDW54160.1 - 1.1e-18 67.0 0.1 6.3e-16 58.1 0.1 2.6 2 0 0 2 2 2 2 SKI/SNO/DAC family PI3_PI4_kinase PF00454.27 CDW54161.1 - 1.5e-46 159.2 0.0 1.9e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ARID PF01388.21 CDW54162.1 - 3e-18 66.3 0.0 4.7e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain FOXP-CC PF16159.5 CDW54163.1 - 1.6e-06 28.6 7.4 0.00058 20.4 0.3 3.1 3 0 0 3 3 3 2 FOXP coiled-coil domain DAZAP2 PF11029.8 CDW54163.1 - 0.14 13.0 0.1 0.14 13.0 0.1 2.6 3 1 0 3 3 3 0 DAZ associated protein 2 (DAZAP2) zf-Di19 PF05605.12 CDW54163.1 - 0.45 10.9 4.8 1.6 9.1 3.1 2.7 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CDW54163.1 - 0.91 10.5 4.5 3.3 8.8 0.9 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger Str_synth PF03088.16 CDW54164.1 - 1.2e-14 54.1 0.1 1.9e-13 50.3 0.1 2.9 2 1 1 3 3 3 1 Strictosidine synthase SGL PF08450.12 CDW54164.1 - 3.7e-09 36.5 0.0 1.4e-08 34.6 0.0 1.7 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 CDW54164.1 - 0.0063 16.5 0.0 2.3 8.4 0.0 3.6 3 0 0 3 3 3 1 NHL repeat Arylesterase PF01731.20 CDW54164.1 - 0.14 12.3 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Arylesterase Acetyltransf_1 PF00583.25 CDW54168.1 - 1.2e-15 57.7 0.0 1.7e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW54168.1 - 1.9e-11 44.0 0.1 3.3e-11 43.2 0.1 1.4 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW54168.1 - 2.8e-09 37.3 0.0 3.9e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW54168.1 - 1.6e-07 31.2 0.0 2.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 CDW54168.1 - 0.0054 16.2 0.2 0.0086 15.6 0.2 1.5 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_13 PF13880.6 CDW54168.1 - 0.023 14.7 0.2 0.06 13.3 0.1 1.8 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.7 CDW54168.1 - 0.025 15.2 0.0 0.032 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PanZ PF12568.8 CDW54168.1 - 0.042 13.6 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_9 PF13527.7 CDW54168.1 - 0.05 13.7 0.1 0.081 13.0 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Hexokinase_2 PF03727.16 CDW54169.1 - 1.2e-55 188.6 0.0 1.7e-55 188.0 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CDW54169.1 - 2.6e-55 187.4 0.0 3.6e-55 187.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF799 PF05643.11 CDW54169.1 - 0.14 11.8 0.4 0.44 10.1 0.1 1.8 2 0 0 2 2 2 0 Putative bacterial lipoprotein (DUF799) Ras PF00071.22 CDW54170.1 - 5.6e-57 191.9 0.0 6.5e-57 191.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW54170.1 - 2.7e-32 111.5 0.0 4e-32 111.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW54170.1 - 1.1e-12 47.8 0.0 1.3e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW54170.1 - 2.2e-07 31.0 0.0 3.5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW54170.1 - 2.8e-05 23.6 0.0 4.1e-05 23.0 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDW54170.1 - 4.6e-05 23.4 0.0 0.0048 16.8 0.1 2.2 1 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CDW54170.1 - 5.3e-05 22.8 0.0 0.0028 17.2 0.0 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDW54170.1 - 0.0031 17.9 0.1 0.016 15.6 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain cobW PF02492.19 CDW54170.1 - 0.0063 16.1 0.0 0.015 14.9 0.0 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDW54170.1 - 0.0071 16.6 0.0 0.014 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 CDW54170.1 - 0.0074 16.0 0.0 0.16 11.7 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_1 PF03029.17 CDW54170.1 - 0.0082 15.9 0.1 0.39 10.5 0.0 2.2 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 CDW54170.1 - 0.013 15.4 0.0 0.029 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SRPRB PF09439.10 CDW54170.1 - 0.017 14.6 0.0 0.043 13.3 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 CDW54170.1 - 0.019 14.5 0.1 0.031 13.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 CDW54170.1 - 0.02 14.6 0.1 0.03 14.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 CDW54170.1 - 0.021 14.1 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 Septin NTPase_1 PF03266.15 CDW54170.1 - 0.035 14.0 0.1 0.059 13.3 0.0 1.4 2 0 0 2 2 1 0 NTPase ATPase_2 PF01637.18 CDW54170.1 - 0.049 13.5 0.4 0.079 12.9 0.1 1.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CDW54170.1 - 0.082 13.4 0.0 0.5 10.9 0.0 1.9 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.12 CDW54170.1 - 0.096 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 CDW54170.1 - 0.1 12.0 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein NB-ARC PF00931.22 CDW54170.1 - 0.13 11.4 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain DAP3 PF10236.9 CDW54170.1 - 0.17 11.0 0.1 0.25 10.5 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_18 PF13238.6 CDW54170.1 - 0.18 12.4 0.0 0.58 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain Tmemb_40 PF10160.9 CDW54171.1 - 3.6e-56 190.5 18.4 4.6e-56 190.1 18.4 1.0 1 0 0 1 1 1 1 Predicted membrane protein Y_phosphatase PF00102.27 CDW54172.1 - 9.5e-62 208.6 2.0 1.3e-61 208.2 2.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW54172.1 - 2.4e-05 24.5 0.0 5.5e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CDW54172.1 - 0.0022 17.8 2.1 0.01 15.7 0.5 2.7 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain DUF410 PF04190.13 CDW54173.1 - 8e-47 160.2 0.0 1e-46 159.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) FlbT PF07378.11 CDW54173.1 - 0.13 12.4 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 Flagellar protein FlbT TPR_14 PF13428.6 CDW54173.1 - 0.47 11.4 1.9 1.2e+02 3.9 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat IML1 PF12257.8 CDW54175.1 - 4.4e-99 331.2 0.2 9.8e-99 330.1 0.2 1.6 2 0 0 2 2 2 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 CDW54175.1 - 1.3e-07 31.6 0.0 4e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Mucin_bdg PF03272.13 CDW54175.1 - 0.15 12.1 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Putative mucin or carbohydrate-binding module Rdx PF10262.9 CDW54176.1 - 5.1e-08 33.0 0.0 5.3e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Rdx family TPD52 PF04201.15 CDW54177.1 - 1.3e-33 115.9 0.9 1.5e-33 115.7 0.9 1.0 1 0 0 1 1 1 1 Tumour protein D52 family Collagen_mid PF15984.5 CDW54177.1 - 0.018 14.8 0.2 0.14 11.9 0.2 2.1 1 1 0 1 1 1 0 Bacterial collagen, middle region kleA_kleC PF17383.2 CDW54177.1 - 0.07 13.5 1.0 0.13 12.6 1.0 1.6 1 1 0 1 1 1 0 Uncharacterized KorC regulated protein A Adap_comp_sub PF00928.21 CDW54178.1 - 4.5e-62 209.8 0.1 3.1e-53 180.8 0.0 2.1 1 1 1 2 2 2 2 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDW54178.1 - 1.3e-06 28.4 0.6 2.6e-06 27.4 0.6 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain 4F5 PF04419.14 CDW54179.1 - 8.5e-10 39.3 14.0 1.2e-09 38.9 14.0 1.2 1 0 0 1 1 1 1 4F5 protein family zf-C2H2_12 PF18658.1 CDW54179.1 - 0.009 15.6 0.4 0.012 15.2 0.4 1.3 1 1 0 1 1 1 1 Zinc-finger C2H2-type SEN1_N PF12726.7 CDW54179.1 - 0.053 11.7 0.2 0.057 11.6 0.2 1.0 1 0 0 1 1 1 0 SEN1 N terminal DUF1644 PF07800.12 CDW54179.1 - 0.059 13.4 3.1 0.075 13.1 3.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) zf-C2H2_4 PF13894.6 CDW54179.1 - 0.079 13.8 0.4 0.079 13.8 0.4 1.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met2 PF12907.7 CDW54179.1 - 0.25 11.5 6.2 2.2 8.5 6.2 2.3 1 1 0 1 1 1 0 Zinc-binding DUF5435 PF17503.2 CDW54180.1 - 0.034 13.9 0.0 0.042 13.6 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5435) Tom6 PF17112.5 CDW54180.1 - 3.3 7.3 4.9 0.76 9.3 1.5 1.6 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal Carb_kinase PF01256.17 CDW54181.1 - 6.2e-55 186.3 0.0 7.7e-55 186.0 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 CDW54181.1 - 0.091 12.1 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family SHE3 PF17078.5 CDW54182.1 - 0.0067 16.2 4.4 0.016 14.9 4.4 1.6 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 UPF0052 PF01933.18 CDW54182.1 - 0.036 13.3 0.3 0.065 12.5 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0052 bZIP_1 PF00170.21 CDW54182.1 - 0.32 11.1 12.5 0.49 10.5 5.8 2.9 1 1 1 2 2 2 0 bZIP transcription factor ELFV_dehydrog_N PF02812.18 CDW54183.1 - 1.3e-115 380.8 0.0 1.1e-56 190.2 0.0 2.5 2 0 0 2 2 2 2 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 CDW54183.1 - 1.2e-92 310.0 1.7 9.9e-48 163.0 0.0 5.1 2 2 2 4 4 4 3 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 CDW54183.1 - 1.4e-05 24.5 0.1 0.078 12.3 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 CDW54183.1 - 2.6e-05 24.4 2.1 0.0096 16.0 0.1 2.6 2 0 0 2 2 2 2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TrkA_N PF02254.18 CDW54183.1 - 0.053 13.8 0.2 9.7 6.5 0.0 2.7 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 CDW54183.1 - 0.11 13.0 0.0 17 5.9 0.0 2.7 2 0 0 2 2 2 0 Putative NAD(P)-binding RtcB PF01139.17 CDW54184.1 - 5.1e-141 470.6 0.0 5.8e-141 470.4 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Thymosin PF01290.20 CDW54184.1 - 0.043 13.5 0.0 0.081 12.7 0.0 1.4 1 0 0 1 1 1 0 Thymosin beta-4 family Glyco_transf_90 PF05686.12 CDW54185.1 - 6.4e-88 295.3 0.4 9.4e-88 294.8 0.4 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 CDW54185.1 - 0.00051 20.4 0.0 0.00088 19.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 CS PF04969.16 CDW54186.1 - 0.0027 18.7 0.0 0.033 15.2 0.0 2.3 2 1 0 2 2 2 1 CS domain SF1-HH PF16275.5 CDW54187.1 - 9.5e-42 141.9 1.6 9.5e-42 141.9 1.6 3.2 3 1 0 3 3 3 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 CDW54187.1 - 8.6e-07 28.7 0.1 1.7e-06 27.8 0.1 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 CDW54187.1 - 0.00019 21.4 8.3 0.00057 19.8 0.7 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 CDW54187.1 - 0.031 14.3 3.4 0.98 9.4 0.0 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDW54187.1 - 0.069 12.9 5.3 3.6 7.4 1.2 2.3 2 0 0 2 2 2 0 Zinc knuckle Rubredoxin_2 PF18073.1 CDW54187.1 - 0.13 12.0 2.2 0.24 11.1 2.2 1.5 1 0 0 1 1 1 0 Rubredoxin metal binding domain zf-CCHC_6 PF15288.6 CDW54187.1 - 5.5 6.9 6.6 2.4 8.0 0.4 2.9 2 0 0 2 2 2 0 Zinc knuckle TPR_2 PF07719.17 CDW54188.1 - 9e-20 69.2 8.5 2.8e-05 23.9 0.2 7.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDW54188.1 - 4.2e-19 67.5 9.5 3.7e-05 23.4 0.1 6.8 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDW54188.1 - 9.4e-12 45.4 4.9 1.5e-08 35.1 0.0 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW54188.1 - 4.7e-11 42.2 0.0 1.6e-05 24.5 0.0 3.5 2 1 1 3 3 2 2 TPR repeat TPR_8 PF13181.6 CDW54188.1 - 7.1e-10 38.3 14.4 0.012 15.7 0.0 6.3 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDW54188.1 - 8.7e-10 38.8 5.3 0.0079 16.5 0.2 5.8 6 1 1 7 7 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW54188.1 - 1.4e-09 38.3 6.3 0.0012 19.3 0.0 5.9 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDW54188.1 - 5.5e-08 32.7 8.7 1.7e-05 24.8 0.1 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW54188.1 - 1.4e-07 31.7 15.0 0.016 16.0 0.2 6.8 5 1 2 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDW54188.1 - 3.7e-06 26.6 5.8 0.17 12.0 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW54188.1 - 1.1e-05 25.4 2.4 0.0012 18.9 0.0 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat DUF982 PF06169.12 CDW54188.1 - 9.3e-05 22.4 4.7 0.082 13.0 1.4 3.6 3 0 0 3 3 3 2 Protein of unknown function (DUF982) TPR_10 PF13374.6 CDW54188.1 - 0.00051 19.8 8.0 0.15 12.0 0.2 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW54188.1 - 0.031 14.5 12.2 1.2 9.4 4.2 4.4 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 CDW54188.1 - 0.066 13.5 7.1 1.8 9.0 0.1 4.3 4 1 1 5 5 4 0 PPR repeat DUF627 PF04781.12 CDW54188.1 - 0.09 12.8 0.4 0.37 10.8 0.4 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF627) TPR_15 PF13429.6 CDW54188.1 - 0.09 12.0 0.1 0.09 12.0 0.1 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat Coatomer_E PF04733.14 CDW54188.1 - 0.13 11.6 0.5 4 6.8 0.0 2.8 3 0 0 3 3 3 0 Coatomer epsilon subunit Fis1_TPR_C PF14853.6 CDW54188.1 - 0.5 10.5 6.9 30 4.8 0.1 4.5 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 CDW54188.1 - 1.2 9.9 9.4 19 6.2 0.2 5.8 7 0 0 7 7 4 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 CDW54189.1 - 2.4e-20 72.9 0.0 4e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kringle PF00051.18 CDW54189.1 - 8.2e-17 61.3 5.1 2.6e-16 59.7 5.1 1.9 1 0 0 1 1 1 1 Kringle domain I-set PF07679.16 CDW54189.1 - 8.6e-16 57.8 0.0 1.5e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54189.1 - 8.6e-11 42.3 0.0 1.8e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 CDW54189.1 - 2e-08 34.4 0.0 5.1e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Pkinase PF00069.25 CDW54189.1 - 5.4e-08 32.5 0.0 8.5e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain ig PF00047.25 CDW54189.1 - 5.4e-08 32.9 0.0 1.2e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 CDW54189.1 - 0.00016 21.8 0.1 0.0015 18.7 0.1 2.3 1 1 0 1 1 1 1 Immunoglobulin V-set domain LRR_8 PF13855.6 CDW54190.1 - 1.6e-47 159.1 45.6 1.4e-10 40.8 1.1 9.3 4 3 7 11 11 11 7 Leucine rich repeat LRR_4 PF12799.7 CDW54190.1 - 4e-26 90.6 44.7 1.4e-05 25.3 0.3 10.3 9 1 1 10 10 10 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDW54190.1 - 3e-17 61.1 25.2 0.0083 16.1 0.0 12.5 14 0 0 14 14 14 6 Leucine Rich repeat LRR_1 PF00560.33 CDW54190.1 - 2.8e-11 42.3 36.5 0.46 11.2 0.5 12.8 10 3 1 11 11 11 7 Leucine Rich Repeat LRR_9 PF14580.6 CDW54190.1 - 5.2e-08 32.6 15.3 0.015 14.8 0.3 5.8 3 3 3 6 6 6 6 Leucine-rich repeat LRR_5 PF13306.6 CDW54190.1 - 0.0015 18.5 0.0 4.2 7.4 0.0 3.1 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) MFS_1 PF07690.16 CDW54192.1 - 9.1e-33 113.6 32.3 1.7e-29 102.9 15.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily RNA_pol_L PF01193.24 CDW54193.1 - 2e-19 68.8 0.0 2.6e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 CDW54193.1 - 1.9e-16 60.4 0.0 4.4e-08 33.5 0.0 2.8 2 1 1 3 3 3 2 RNA polymerase Rpb3/RpoA insert domain WD40 PF00400.32 CDW54194.1 - 1e-13 51.5 14.4 0.0049 17.7 0.1 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW54194.1 - 1.2e-09 38.3 2.1 0.0034 17.6 0.0 4.4 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW54194.1 - 0.0012 18.7 1.6 0.01 15.8 1.0 2.6 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 CDW54194.1 - 0.051 13.5 0.0 1.2 9.2 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat RRM_1 PF00076.22 CDW54195.1 - 1.2e-09 37.8 0.4 4.3e-08 32.9 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP-alpha_N PF04086.13 CDW54195.1 - 0.024 14.6 14.1 0.037 13.9 14.1 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SR-25 PF10500.9 CDW54195.1 - 0.22 11.1 28.8 0.35 10.4 28.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SOBP PF15279.6 CDW54195.1 - 0.33 11.5 23.2 0.65 10.6 23.2 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Raftlin PF15250.6 CDW54195.1 - 0.41 9.4 6.5 0.58 8.8 6.5 1.1 1 0 0 1 1 1 0 Raftlin CDC45 PF02724.14 CDW54195.1 - 1.1 7.5 11.2 1.7 6.9 11.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 CDW54195.1 - 2.3 8.2 6.1 3.6 7.6 6.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 CDW54195.1 - 4.1 7.1 12.4 6.9 6.4 12.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 U1snRNP70_N PF12220.8 CDW54195.1 - 5.3 7.7 9.9 0.44 11.2 3.7 2.3 1 1 1 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal MAJIN PF15077.6 CDW54195.1 - 8.8 6.0 12.2 16 5.2 12.2 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein MRI PF15325.6 CDW54195.1 - 9.5 7.4 11.9 24 6.1 11.9 1.7 1 0 0 1 1 1 0 Modulator of retrovirus infection fn3 PF00041.21 CDW54196.1 - 1.4e-126 413.2 34.1 5.8e-11 42.6 0.1 14.4 14 0 0 14 14 14 13 Fibronectin type III domain Utp21 PF04192.12 CDW54196.1 - 2.1e-55 187.8 1.1 3.4e-55 187.1 1.1 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain Ig_3 PF13927.6 CDW54196.1 - 2e-54 182.1 0.0 3.3e-13 50.0 0.0 7.2 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 CDW54196.1 - 9.5e-45 150.6 0.0 1.3e-10 41.2 0.0 6.8 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW54196.1 - 7.5e-43 144.8 0.0 2.7e-09 37.2 0.1 6.6 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 CDW54196.1 - 1.7e-25 89.0 0.0 8.6e-05 22.6 0.1 6.1 5 0 0 5 5 5 4 Immunoglobulin domain WD40 PF00400.32 CDW54196.1 - 3.9e-15 56.0 6.7 2.8e-07 31.1 0.6 9.1 10 0 0 10 10 9 1 WD domain, G-beta repeat V-set PF07686.17 CDW54196.1 - 4.4e-14 52.6 2.2 0.64 10.2 0.1 8.8 6 3 1 7 7 6 3 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 CDW54196.1 - 3.9e-13 49.8 20.7 0.03 14.9 0.0 10.3 11 0 0 11 11 11 3 Purple acid Phosphatase, N-terminal domain ANAPC4_WD40 PF12894.7 CDW54196.1 - 8.4e-12 45.2 0.0 0.011 16.0 0.0 5.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ig_6 PF18452.1 CDW54196.1 - 3e-08 33.1 0.1 0.29 10.7 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin domain DUF2369 PF10179.9 CDW54196.1 - 0.00038 20.8 0.0 6.3 7.3 0.0 5.4 7 0 0 7 7 6 1 Uncharacterised conserved protein (DUF2369) Ig_5 PF16681.5 CDW54196.1 - 0.0021 18.4 0.1 7.2 7.1 0.0 4.3 4 1 0 4 4 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain fn3_4 PF16794.5 CDW54196.1 - 0.025 14.5 0.2 66 3.5 0.0 5.3 5 0 0 5 5 5 0 Fibronectin-III type domain Adeno_E3_CR1 PF02440.15 CDW54196.1 - 0.072 12.9 0.7 0.98 9.2 0.1 3.2 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Ig_C17orf99 PF17736.1 CDW54196.1 - 0.13 12.3 0.0 77 3.4 0.0 4.0 4 0 0 4 4 4 0 C17orf99 Ig domain Kelch_1 PF01344.25 CDW54197.1 - 1.2e-29 101.6 13.8 4.3e-09 35.8 0.1 6.2 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 CDW54197.1 - 3.3e-26 90.2 11.1 1.2e-05 25.1 0.1 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 CDW54197.1 - 1.3e-24 85.6 16.2 5.5e-05 23.3 0.1 6.2 4 2 2 6 6 6 5 Kelch motif Kelch_4 PF13418.6 CDW54197.1 - 5e-24 84.1 10.6 1.5e-07 31.3 0.1 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CDW54197.1 - 2.2e-23 81.8 11.6 1.9e-06 27.7 0.2 6.2 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 CDW54197.1 - 5e-21 74.5 11.8 9.4e-05 22.6 0.0 7.2 7 0 0 7 7 7 5 Galactose oxidase, central domain Trypsin PF00089.26 CDW54198.1 - 3.4e-69 233.0 0.0 4.6e-69 232.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 CDW54198.1 - 4.2e-06 27.1 0.0 9.3e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 CDW54198.1 - 0.00023 22.1 0.0 0.00054 20.9 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S6 PF02395.16 CDW54198.1 - 0.011 13.8 0.0 0.039 12.0 0.1 1.7 2 0 0 2 2 2 0 Immunoglobulin A1 protease Y_phosphatase PF00102.27 CDW54199.1 - 2.6e-52 177.7 0.1 3.5e-52 177.3 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW54199.1 - 0.00058 19.9 0.0 0.00092 19.2 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CDW54199.1 - 0.0023 17.7 0.1 0.0073 16.1 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW54199.1 - 0.076 13.1 0.0 0.28 11.3 0.0 2.0 2 0 0 2 2 2 0 Inositol hexakisphosphate Acyl-CoA_dh_N PF02771.16 CDW54200.1 - 1.6e-08 35.2 0.0 4.7e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CDW54200.1 - 0.06 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CDW54200.1 - 0.09 13.0 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Tfb5 PF06331.12 CDW54201.1 - 1.3e-26 92.3 0.3 1.4e-26 92.3 0.3 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Ribosomal_L18A PF01775.17 CDW54202.1 - 2.2e-51 173.0 0.2 3.8e-51 172.2 0.2 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Cytochrom_C PF00034.21 CDW54202.1 - 1.5e-10 42.1 0.0 3.6e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CDW54202.1 - 1.7e-06 28.2 0.8 1.2e-05 25.5 0.8 2.2 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CDW54202.1 - 0.00047 19.9 0.2 0.011 15.5 0.2 2.3 2 0 0 2 2 2 1 Cytochrome c-550 domain ABC_tran PF00005.27 CDW54203.1 - 2e-36 125.6 0.0 6.4e-17 62.4 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDW54203.1 - 5.1e-06 26.5 3.7 0.56 10.0 0.3 4.1 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 CDW54203.1 - 1.8e-05 24.1 34.3 0.071 12.2 0.0 4.0 2 1 1 3 3 3 3 ABC-2 family transporter protein AAA_23 PF13476.6 CDW54203.1 - 2.7e-05 24.7 0.6 0.013 16.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDW54203.1 - 8.3e-05 23.0 0.0 0.14 12.6 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CDW54203.1 - 0.00039 20.1 0.2 0.1 12.4 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDW54203.1 - 0.0013 19.0 0.0 0.28 11.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CDW54203.1 - 0.002 18.1 0.1 0.36 10.7 0.0 2.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea ACDC PF14733.6 CDW54203.1 - 0.035 14.4 0.1 0.14 12.5 0.1 2.1 1 0 0 1 1 1 0 AP2-coincident C-terminal MMR_HSR1 PF01926.23 CDW54203.1 - 0.18 11.9 0.3 12 6.0 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase DAO PF01266.24 CDW54204.1 - 6.2e-46 157.6 0.0 6.8e-38 131.1 0.0 2.1 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDW54204.1 - 5.8e-05 23.2 0.2 0.00015 21.9 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CDW54204.1 - 5.9e-05 22.4 0.1 0.00011 21.6 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Mqo PF06039.15 CDW54204.1 - 0.00023 19.9 0.0 0.00074 18.2 0.0 1.7 2 0 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) FAD_binding_2 PF00890.24 CDW54204.1 - 0.00023 20.3 0.5 0.00033 19.9 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CDW54204.1 - 0.00039 19.6 0.1 0.00063 18.9 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CDW54204.1 - 0.00072 18.9 0.2 0.0011 18.3 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDW54204.1 - 0.0082 16.7 0.9 0.022 15.3 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CDW54204.1 - 0.026 13.4 0.2 0.041 12.7 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase PALP PF00291.25 CDW54204.1 - 0.03 13.7 0.0 0.12 11.8 0.1 1.8 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme TrkA_N PF02254.18 CDW54204.1 - 0.057 13.7 0.2 0.11 12.7 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain UNC-50 PF05216.13 CDW54205.1 - 6e-80 267.9 22.9 7e-80 267.7 22.9 1.0 1 0 0 1 1 1 1 UNC-50 family zf-BED PF02892.15 CDW54206.1 - 5.2e-06 26.4 0.0 9.2e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_12 PF18658.1 CDW54206.1 - 0.0012 18.4 0.1 0.0026 17.3 0.1 1.7 2 0 0 2 2 2 1 Zinc-finger C2H2-type OrsD PF12013.8 CDW54206.1 - 0.028 14.9 0.5 0.06 13.8 0.1 1.7 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_4 PF13894.6 CDW54206.1 - 0.087 13.7 0.6 0.25 12.3 0.6 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CDW54206.1 - 0.3 10.9 1.6 0.66 9.8 1.6 1.6 1 0 0 1 1 1 0 C2H2-type zinc-finger domain AMOP PF03782.17 CDW54207.1 - 1.6e-42 145.0 7.3 2.9e-42 144.2 7.3 1.5 1 0 0 1 1 1 1 AMOP domain NIDO PF06119.14 CDW54207.1 - 8.7e-16 58.7 1.1 2.3e-15 57.3 1.1 1.7 1 0 0 1 1 1 1 Nidogen-like VWD PF00094.25 CDW54207.1 - 5.4e-13 49.5 5.0 2e-07 31.4 1.1 3.0 2 1 0 2 2 2 2 von Willebrand factor type D domain Cytochrome_B PF00033.19 CDW54207.1 - 0.17 11.7 0.3 0.32 10.8 0.3 1.4 1 0 0 1 1 1 0 Cytochrome b/b6/petB La PF05383.17 CDW54208.1 - 4.8e-22 77.8 0.0 4.8e-22 77.8 0.0 2.6 3 0 0 3 3 3 1 La domain UCH PF00443.29 CDW54209.1 - 8.7e-40 136.8 0.0 1.3e-39 136.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 CDW54209.1 - 1e-24 86.0 3.3 2.7e-24 84.7 1.6 2.5 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 CDW54209.1 - 1e-16 61.0 2.4 2.5e-12 46.9 0.0 2.9 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 CDW54209.1 - 4.9e-14 52.6 0.0 1.2e-13 51.3 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 CDW54209.1 - 2.4e-07 30.5 0.0 5.2e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain DUF2180 PF09947.9 CDW54209.1 - 0.046 13.7 0.8 0.13 12.2 0.8 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) Pecanex_C PF05041.15 CDW54210.1 - 3.2e-107 357.3 0.0 5e-107 356.7 0.0 1.2 1 0 0 1 1 1 1 Pecanex protein (C-terminus) ERCC4 PF02732.15 CDW54211.1 - 1.8e-19 70.5 0.0 4.7e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 ERCC4 domain DUF4364 PF14277.6 CDW54211.1 - 0.0095 15.7 0.2 0.029 14.1 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4364) Glyco_hydro_35 PF01301.19 CDW54212.1 - 3.3e-107 358.8 0.0 4.1e-107 358.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 CDW54212.1 - 2.9e-12 46.6 0.3 2e-11 43.9 0.3 1.9 1 1 0 1 1 1 1 Beta-galactosidase BetaGal_dom4_5 PF13364.6 CDW54212.1 - 0.00015 22.4 0.1 0.00055 20.5 0.0 1.9 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain Pkinase PF00069.25 CDW54213.1 - 2.9e-59 200.6 0.0 4.6e-59 199.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54213.1 - 2.1e-40 138.6 0.0 3e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW54213.1 - 0.00039 19.8 0.0 0.00066 19.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family AMP_N PF05195.16 CDW54214.1 - 1.1e-10 41.3 0.0 1.9e-10 40.6 0.0 1.4 1 1 0 1 1 1 1 Aminopeptidase P, N-terminal domain DnaJ_C PF01556.18 CDW54215.1 - 9.1e-37 126.4 0.1 1.2e-36 126.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDW54215.1 - 9.2e-24 83.4 1.1 9.2e-24 83.4 1.1 1.7 2 0 0 2 2 2 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDW54215.1 - 2e-12 47.3 16.2 1.3e-11 44.6 16.5 2.1 1 1 1 2 2 2 1 DnaJ central domain gag_pre-integrs PF13976.6 CDW54215.1 - 0.17 11.7 0.8 1.7 8.6 0.1 2.6 2 0 0 2 2 2 0 GAG-pre-integrase domain Anti-TRAP PF15777.5 CDW54215.1 - 0.26 11.3 11.1 3.6 7.6 1.9 3.0 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-TFIIB PF13453.6 CDW54215.1 - 2.3 7.6 10.1 0.27 10.6 0.9 2.6 2 0 0 2 2 2 0 Transcription factor zinc-finger HypA PF01155.19 CDW54215.1 - 3.8 7.6 8.5 2.6 8.1 2.8 2.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Yip1 PF04893.17 CDW54216.1 - 2.4e-08 33.9 15.4 3e-08 33.6 15.4 1.1 1 0 0 1 1 1 1 Yip1 domain LisH_2 PF16045.5 CDW54216.1 - 0.034 13.2 0.1 0.065 12.3 0.1 1.5 1 0 0 1 1 1 0 LisH CAF1C_H4-bd PF12265.8 CDW54217.1 - 2.9e-22 78.7 0.0 1.2e-19 70.3 0.0 3.5 4 0 0 4 4 4 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CDW54217.1 - 3.7e-20 71.9 14.2 0.00013 22.7 0.1 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat eIF2A PF08662.11 CDW54217.1 - 0.0034 17.3 0.6 0.014 15.3 0.0 2.2 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 CDW54217.1 - 0.0062 16.8 1.6 2.5 8.5 0.0 4.3 3 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain mTERF PF02536.14 CDW54218.1 - 1.9e-09 36.9 0.0 4.2e-06 25.9 0.0 2.3 1 1 1 2 2 2 2 mTERF DUF543 PF04418.12 CDW54219.1 - 1.1e-18 67.0 0.5 6.4e-11 42.1 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF543) HEAT PF02985.22 CDW54220.1 - 2.3e-15 55.4 16.5 0.00067 19.7 0.0 9.5 11 0 0 11 11 11 4 HEAT repeat IBN_N PF03810.19 CDW54220.1 - 2.4e-12 46.6 1.3 5.5e-09 35.8 0.0 4.7 5 1 1 6 6 6 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 CDW54220.1 - 1.3e-10 41.6 6.8 1.4e-05 25.5 0.1 5.9 6 1 1 7 7 6 2 HEAT-like repeat HEAT_2 PF13646.6 CDW54220.1 - 1.2e-06 28.8 1.6 0.015 15.7 0.0 6.1 5 2 2 7 7 7 1 HEAT repeats Cnd1 PF12717.7 CDW54220.1 - 1.8e-05 24.9 6.4 0.00058 19.9 0.1 3.7 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 CDW54220.1 - 0.00022 21.1 2.2 1.3 9.0 0.0 4.8 4 1 1 5 5 5 1 UME (NUC010) domain MMS19_C PF12460.8 CDW54220.1 - 0.0018 17.5 7.4 0.27 10.3 1.4 4.7 2 1 2 5 5 5 1 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 CDW54220.1 - 0.0065 17.0 11.6 0.29 11.7 0.2 5.5 3 2 2 6 6 6 1 Vacuolar 14 Fab1-binding region Arm PF00514.23 CDW54220.1 - 0.007 16.4 4.7 0.089 12.9 0.3 3.9 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat ParcG PF10274.9 CDW54220.1 - 0.017 15.2 0.1 0.46 10.6 0.0 2.7 3 0 0 3 3 3 0 Parkin co-regulated protein Sec7_N PF12783.7 CDW54220.1 - 0.31 10.9 6.3 13 5.6 1.5 3.3 3 2 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3385 PF11865.8 CDW54220.1 - 0.32 10.9 7.1 0.52 10.2 0.0 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF3385) Sugar_tr PF00083.24 CDW54221.1 - 1.6e-21 76.7 34.9 2.1e-21 76.3 34.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW54221.1 - 5.3e-16 58.5 32.9 1.1e-15 57.4 32.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily CIAPIN1 PF05093.13 CDW54222.1 - 9e-22 77.5 14.2 8.8e-18 64.7 1.7 2.6 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Thymidylat_synt PF00303.19 CDW54223.1 - 1.4e-111 371.9 0.0 1.6e-111 371.8 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase CP2 PF04516.15 CDW54224.1 - 1.4e-55 188.1 0.6 2.5e-55 187.3 0.6 1.3 1 0 0 1 1 1 1 CP2 transcription factor Homeodomain PF00046.29 CDW54226.1 - 1.2e-64 213.9 21.6 5.5e-18 64.6 2.2 4.7 4 0 0 4 4 4 4 Homeodomain Homeobox_KN PF05920.11 CDW54226.1 - 6.3e-17 61.2 0.2 0.00028 20.7 0.1 4.8 4 0 0 4 4 4 4 Homeobox KN domain zf-C2H2_4 PF13894.6 CDW54226.1 - 2.6e-08 34.0 84.6 0.077 13.9 0.4 13.5 13 0 0 13 13 13 6 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW54226.1 - 0.0012 18.8 55.3 0.011 15.8 0.7 9.2 10 0 0 10 10 10 4 C2H2-type zinc finger zf-met PF12874.7 CDW54226.1 - 0.0015 18.8 1.7 0.0015 18.8 1.7 9.8 11 0 0 11 11 10 3 Zinc-finger of C2H2 type MerR_1 PF13411.6 CDW54226.1 - 0.0032 17.5 0.5 1.3 9.2 0.0 4.0 4 0 0 4 4 4 1 MerR HTH family regulatory protein Terminase_5 PF06056.12 CDW54226.1 - 0.013 15.3 0.8 0.36 10.7 0.1 3.1 3 0 0 3 3 3 0 Putative ATPase subunit of terminase (gpP-like) Homez PF11569.8 CDW54226.1 - 0.014 14.9 0.2 6.9 6.2 0.1 2.9 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez zf-C2H2 PF00096.26 CDW54226.1 - 0.02 15.4 1.2 0.02 15.4 1.2 11.7 13 0 0 13 13 11 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CDW54226.1 - 0.021 15.2 0.4 0.021 15.2 0.4 10.2 9 2 2 11 11 11 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 CDW54226.1 - 0.14 12.8 0.0 0.14 12.8 0.0 9.7 11 1 1 12 12 11 0 Zinc finger C2H2-type, 3 repeats HTH_32 PF13565.6 CDW54226.1 - 0.21 12.2 3.4 13 6.5 0.0 3.8 4 0 0 4 4 4 0 Homeodomain-like domain SieB PF14163.6 CDW54226.1 - 0.39 10.2 1.7 5 6.6 0.3 2.6 2 0 0 2 2 2 0 Super-infection exclusion protein B zf-C2H2_3 PF13878.6 CDW54226.1 - 1.3 8.9 24.3 4.5 7.2 0.8 7.1 7 0 0 7 7 7 0 zinc-finger of acetyl-transferase ESCO zf-C2H2_jaz PF12171.8 CDW54226.1 - 1.8 9.0 50.8 0.12 12.7 0.7 10.3 11 0 0 11 11 10 0 Zinc-finger double-stranded RNA-binding zf-C2H2_jaz PF12171.8 CDW54227.1 - 0.006 16.8 1.5 0.006 16.8 1.5 3.6 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CDW54227.1 - 0.017 15.5 1.6 0.017 15.5 1.6 2.0 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 CDW54227.1 - 0.058 13.6 2.4 1.2 9.3 0.2 2.1 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.26 CDW54228.1 - 6.5e-06 26.3 36.2 0.0027 18.1 0.5 5.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 CDW54228.1 - 0.00013 21.7 29.8 0.0012 18.5 1.0 4.9 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-met PF12874.7 CDW54228.1 - 0.0013 19.1 0.3 0.0013 19.1 0.3 5.2 5 0 0 5 5 5 2 Zinc-finger of C2H2 type Elf1 PF05129.13 CDW54228.1 - 0.029 14.4 0.8 0.029 14.4 0.8 4.2 4 1 0 4 4 4 0 Transcription elongation factor Elf1 like zf-C2H2_4 PF13894.6 CDW54228.1 - 0.065 14.1 40.1 1.4 9.9 3.6 7.4 6 0 0 6 6 6 0 C2H2-type zinc finger CpXC PF14353.6 CDW54228.1 - 0.21 11.6 10.5 28 4.8 0.1 4.3 4 0 0 4 4 4 0 CpXC protein zf-C2H2_2 PF12756.7 CDW54228.1 - 0.29 11.5 40.5 1.8 8.9 0.1 6.5 5 2 1 6 6 6 0 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 CDW54228.1 - 0.29 11.4 0.1 0.084 13.1 0.8 5.0 6 0 0 6 6 6 0 A-kinase anchoring protein 95 (AKAP95) Zn_ribbon_SprT PF17283.2 CDW54228.1 - 2.3 8.2 14.8 9.2 6.3 7.2 4.2 3 1 0 3 3 3 0 SprT-like zinc ribbon domain zf-C2H2 PF00096.26 CDW54229.1 - 8.3e-15 54.3 12.5 2.7e-06 27.5 0.8 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW54229.1 - 2.1e-13 50.0 8.1 1.1e-05 25.6 0.9 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW54229.1 - 2.4e-12 46.6 11.4 0.00062 20.4 1.0 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW54229.1 - 2.6e-06 27.5 8.4 0.0015 18.8 0.6 2.8 3 0 0 3 3 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW54229.1 - 5.5e-05 23.1 10.1 0.00039 20.3 0.1 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 CDW54229.1 - 0.002 18.4 2.0 0.002 18.4 2.0 2.0 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 CDW54229.1 - 0.0031 17.2 10.1 0.43 10.4 0.5 3.3 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2HE PF16278.5 CDW54229.1 - 0.0041 17.5 9.4 0.13 12.7 0.7 3.2 2 1 1 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 CDW54229.1 - 0.0054 17.1 9.4 0.21 12.1 0.8 2.9 3 0 0 3 3 2 2 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 CDW54229.1 - 0.0088 15.9 1.1 0.0088 15.9 1.1 2.7 3 0 0 3 3 3 1 zinc-finger of a C2HC-type Elf1 PF05129.13 CDW54229.1 - 0.017 15.1 4.2 0.84 9.7 0.9 2.3 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_2 PF12756.7 CDW54229.1 - 0.02 15.2 8.9 0.13 12.6 0.5 2.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) BolA PF01722.18 CDW54229.1 - 0.041 14.1 0.3 0.085 13.1 0.3 1.5 1 0 0 1 1 1 0 BolA-like protein C1_4 PF07975.12 CDW54229.1 - 0.054 13.7 5.9 2.6 8.4 1.0 2.9 3 1 0 3 3 2 0 TFIIH C1-like domain Sprouty PF05210.13 CDW54229.1 - 0.077 13.4 4.8 0.15 12.4 1.1 2.2 2 0 0 2 2 2 0 Sprouty protein (Spry) Zn-ribbon_8 PF09723.10 CDW54229.1 - 0.098 12.8 9.8 1 9.5 3.3 2.9 2 1 1 3 3 3 0 Zinc ribbon domain zf-AN1 PF01428.16 CDW54229.1 - 0.1 12.8 6.5 5.6 7.2 0.1 3.4 3 0 0 3 3 3 0 AN1-like Zinc finger SIR2 PF02146.17 CDW54229.1 - 0.11 12.4 0.6 0.21 11.5 0.6 1.5 1 1 0 1 1 1 0 Sir2 family LIM PF00412.22 CDW54229.1 - 0.2 11.9 10.0 3.4 8.0 4.0 3.0 1 1 1 2 2 2 0 LIM domain zinc_ribbon_15 PF17032.5 CDW54229.1 - 0.25 12.1 3.7 2.4 9.0 3.0 2.3 1 1 1 2 2 2 0 zinc-ribbon family zf-H2C2_5 PF13909.6 CDW54229.1 - 0.28 11.0 0.0 0.28 11.0 0.0 3.3 3 1 0 3 3 2 0 C2H2-type zinc-finger domain CpXC PF14353.6 CDW54229.1 - 0.32 11.1 3.5 7.2 6.7 0.1 2.5 1 1 0 2 2 2 0 CpXC protein HypA PF01155.19 CDW54229.1 - 0.34 10.9 5.7 8.3 6.5 3.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_3rep PF18868.1 CDW54229.1 - 0.45 11.2 5.4 19 6.0 5.4 2.8 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-HYPF PF07503.12 CDW54229.1 - 1.6 8.6 4.2 1.6 8.6 0.6 2.7 2 1 0 2 2 2 0 HypF finger zf-CHY PF05495.12 CDW54229.1 - 1.8 9.1 9.0 11 6.6 4.0 2.4 1 1 1 2 2 2 0 CHY zinc finger FYVE PF01363.21 CDW54229.1 - 2.6 8.3 9.9 1.3 9.2 3.2 2.4 1 1 1 2 2 2 0 FYVE zinc finger Evr1_Alr PF04777.13 CDW54229.1 - 7 7.2 6.2 17 6.0 1.7 2.7 1 1 1 2 2 2 0 Erv1 / Alr family MOLO1 PF17175.4 CDW54230.1 - 0.00024 21.2 0.2 0.003 17.7 0.2 2.3 1 1 0 1 1 1 1 Modulator of levamisole receptor-1 ADSL_C PF10397.9 CDW54230.1 - 0.06 13.9 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminus Pkinase_Tyr PF07714.17 CDW54231.1 - 3.6e-15 56.0 0.6 5.6e-15 55.3 0.6 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW54231.1 - 2.8e-10 40.0 1.0 4.4e-10 39.4 1.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW54231.1 - 7.3e-06 26.0 0.1 3.4e-05 23.9 0.1 2.1 2 1 0 2 2 2 1 SH2 domain Zona_pellucida PF00100.23 CDW54232.1 - 6.2e-10 39.3 2.0 1.5e-09 38.1 2.0 1.7 1 1 0 1 1 1 1 Zona pellucida-like domain CAMSAP_CKK PF08683.11 CDW54233.1 - 4.2e-06 26.9 1.6 10 6.3 0.0 5.5 6 0 0 6 6 6 3 Microtubule-binding calmodulin-regulated spectrin-associated Stevor PF17410.2 CDW54233.1 - 0.00018 21.2 2.2 42 3.6 0.1 5.5 5 1 0 6 6 6 0 Subtelomeric Variable Open Reading frame DUF3926 PF13080.6 CDW54233.1 - 0.00082 19.3 0.0 2e+02 2.0 0.0 5.5 6 0 0 6 6 6 0 Protein of unknown function (DUF3926) Flavodoxin_5 PF12724.7 CDW54233.1 - 0.0045 17.2 0.0 2.7e+02 1.7 0.0 5.3 6 0 0 6 6 6 0 Flavodoxin domain ETF_alpha PF00766.19 CDW54233.1 - 0.017 15.2 9.1 82 3.3 0.0 5.3 6 0 0 6 6 6 0 Electron transfer flavoprotein FAD-binding domain Pkinase PF00069.25 CDW54234.1 - 2.7e-26 92.5 0.0 3.8e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54234.1 - 2.1e-15 56.7 0.0 3.2e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW54234.1 - 0.0027 17.1 0.0 0.0065 15.8 0.0 1.9 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDW54234.1 - 0.0081 15.0 0.0 0.01 14.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase PP2C PF00481.21 CDW54235.1 - 1e-41 143.3 0.0 2.6e-37 128.9 0.0 2.3 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CDW54235.1 - 0.00017 21.3 0.0 0.0034 17.1 0.0 2.3 1 1 0 1 1 1 1 Protein phosphatase 2C Flavi_glycop_C PF02832.16 CDW54235.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Flavivirus glycoprotein, immunoglobulin-like domain 7tm_1 PF00001.21 CDW54236.1 - 1.1e-48 165.9 23.2 1.5e-48 165.4 23.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW54236.1 - 2.6e-10 40.1 24.2 4.3e-10 39.4 24.2 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 CDW54236.1 - 5.9e-07 29.1 23.7 1.2e-06 28.1 23.7 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srw PF10324.9 CDW54236.1 - 4.4e-06 26.2 30.0 0.00054 19.3 6.6 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srx PF10328.9 CDW54236.1 - 1.6e-05 24.7 17.2 1.6e-05 24.7 17.2 2.4 2 2 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Ocular_alb PF02101.15 CDW54236.1 - 0.00048 19.2 6.4 0.013 14.5 0.5 2.2 2 0 0 2 2 2 2 Ocular albinism type 1 protein UPF0715 PF17094.5 CDW54236.1 - 0.0021 18.6 5.3 0.0021 18.6 5.3 3.5 3 2 1 4 4 4 1 Uncharacterised protein family (UPF0715) MFS_1 PF07690.16 CDW54237.1 - 7.3e-22 77.8 38.4 7.3e-22 77.8 38.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily COX8 PF02285.15 CDW54237.1 - 0.62 10.0 3.6 13 5.7 0.5 3.7 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIII Sema PF01403.19 CDW54238.1 - 6.7e-106 354.6 0.0 1.2e-105 353.8 0.0 1.4 2 0 0 2 2 2 1 Sema domain PSI PF01437.25 CDW54238.1 - 2.1e-05 25.0 5.6 9e-05 22.9 5.6 2.2 1 0 0 1 1 1 1 Plexin repeat TSNAXIP1_N PF15739.5 CDW54238.1 - 0.18 12.2 0.1 0.35 11.3 0.1 1.4 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus Collagen PF01391.18 CDW54240.1 - 4e-26 90.5 99.1 3.7e-10 39.4 33.7 4.1 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW54240.1 - 9.5e-16 57.6 0.2 1.3e-15 57.2 0.2 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain MMS1_N PF10433.9 CDW54241.1 - 1.7e-148 495.3 0.0 5.5e-148 493.6 0.0 1.8 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CDW54241.1 - 8.2e-89 298.1 0.1 1.1e-87 294.4 0.0 2.3 2 0 0 2 2 2 1 CPSF A subunit region CBAH PF02275.18 CDW54242.1 - 1.4e-18 67.6 0.1 2e-16 60.5 0.1 2.1 1 1 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.6 CDW54242.1 - 3.1e-15 56.2 1.1 8e-15 54.9 0.5 2.0 2 0 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase eIF3_N PF09440.10 CDW54243.1 - 2.5e-31 108.9 2.5 5.3e-31 107.8 2.5 1.6 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 CDW54243.1 - 1.6e-13 51.0 0.0 4.4e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 PCI domain EF-hand_6 PF13405.6 CDW54244.1 - 4.8e-19 66.6 4.9 2.4e-06 27.0 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 CDW54244.1 - 6.6e-18 62.9 9.4 2e-07 30.0 0.2 4.7 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 CDW54244.1 - 1.5e-16 60.6 3.4 1.7e-08 34.8 1.9 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 CDW54244.1 - 1.5e-13 50.4 7.3 5.8e-10 38.9 0.3 4.3 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 CDW54244.1 - 4e-12 45.1 5.1 0.00022 20.6 0.4 4.3 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 CDW54244.1 - 0.0015 18.8 0.1 2.9 8.3 0.0 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDW54244.1 - 0.09 12.7 0.1 0.2 11.6 0.1 1.6 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Histone PF00125.24 CDW54245.1 - 1.1e-18 67.8 0.8 1.4e-11 44.9 0.1 2.1 1 1 1 2 2 2 2 Core histone H2A/H2B/H3/H4 RP-C PF03428.13 CDW54245.1 - 0.0012 18.6 0.2 0.53 9.9 0.0 2.7 1 1 2 3 3 3 2 Replication protein C N-terminal domain DUF3818 PF12825.7 CDW54245.1 - 0.0019 17.3 0.4 0.016 14.3 0.1 1.9 1 1 1 2 2 2 1 Domain of unknown function in PX-proteins (DUF3818) CBFD_NFYB_HMF PF00808.23 CDW54245.1 - 0.063 13.6 0.1 0.38 11.1 0.0 2.2 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF4214 PF13946.6 CDW54245.1 - 0.18 11.9 0.1 5.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4214) PAS_11 PF14598.6 CDW54246.1 - 2.8e-19 69.3 0.1 9.5e-15 54.7 0.0 3.2 4 0 0 4 4 4 2 PAS domain PAS_3 PF08447.12 CDW54246.1 - 1.8e-16 60.2 0.2 9.3e-12 45.1 0.1 2.6 2 0 0 2 2 2 2 PAS fold HLH PF00010.26 CDW54246.1 - 1.6e-13 50.4 0.7 2.8e-13 49.6 0.7 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 CDW54246.1 - 1.2e-05 25.5 0.0 0.0022 18.2 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 CDW54246.1 - 1.2e-05 25.2 0.0 0.0061 16.6 0.0 2.9 2 1 0 2 2 2 2 PAS fold PAS_4 PF08448.10 CDW54246.1 - 8.6e-05 22.8 0.0 0.017 15.4 0.0 2.5 2 0 0 2 2 2 1 PAS fold HEPN_Cthe2314 PF18730.1 CDW54246.1 - 0.19 11.8 0.1 0.36 10.9 0.1 1.4 1 0 0 1 1 1 0 Cthe_2314-like HEPN FliH PF02108.16 CDW54246.1 - 0.22 11.6 0.3 14 5.8 0.0 2.3 2 0 0 2 2 2 0 Flagellar assembly protein FliH Ldl_recept_a PF00057.18 CDW54247.1 - 2.3e-79 261.3 147.1 2.2e-12 47.0 10.5 9.3 9 1 0 9 9 9 8 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 CDW54247.1 - 8.2e-39 131.8 6.0 3.4e-12 46.6 0.2 5.7 5 1 0 5 5 5 5 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 CDW54247.1 - 2.5e-10 40.5 36.9 5e-07 29.9 10.7 7.3 8 2 0 8 8 8 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW54247.1 - 3.2e-09 36.6 27.4 2.4e-05 24.2 0.6 5.7 5 0 0 5 5 5 3 Complement Clr-like EGF-like EGF_CA PF07645.15 CDW54247.1 - 1.1e-08 35.1 8.7 1.1e-08 35.1 8.7 9.9 6 3 2 8 8 8 2 Calcium-binding EGF domain SGL PF08450.12 CDW54247.1 - 6.7e-06 25.9 0.6 0.021 14.4 0.1 3.3 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region SIT PF15330.6 CDW54247.1 - 0.082 13.3 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Spond_N PF06468.13 CDW54248.1 - 5.1e-74 248.6 0.0 1.2e-73 247.4 0.0 1.7 2 0 0 2 2 2 1 Spondin_N TSP_1 PF00090.19 CDW54248.1 - 1.4e-49 166.1 56.1 3e-11 43.4 10.0 5.7 5 0 0 5 5 5 5 Thrombospondin type 1 domain Reeler PF02014.16 CDW54248.1 - 2.3e-20 73.7 0.0 5.2e-20 72.5 0.0 1.6 1 0 0 1 1 1 1 Reeler domain Kunitz_BPTI PF00014.23 CDW54248.1 - 1.7e-14 53.8 3.7 1.7e-14 53.8 3.7 3.0 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Peptidase_M23 PF01551.22 CDW54249.1 - 4.1e-13 49.3 0.0 6.1e-10 39.2 0.0 2.3 2 0 0 2 2 2 2 Peptidase family M23 zf-CHCC PF10276.9 CDW54250.1 - 5.2e-19 68.0 1.3 8.4e-19 67.3 1.3 1.4 1 0 0 1 1 1 1 Zinc-finger domain zf_C2H2_6 PF18450.1 CDW54250.1 - 0.041 13.6 0.1 0.12 12.1 0.1 1.8 1 0 0 1 1 1 0 Zinc Finger domain Thymidylate_kin PF02223.17 CDW54251.1 - 5.2e-36 124.0 0.0 3.1e-35 121.5 0.0 1.8 1 1 0 1 1 1 1 Thymidylate kinase WRW PF10206.9 CDW54252.1 - 4e-23 81.7 0.1 6.3e-23 81.1 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f START PF01852.19 CDW54254.1 - 3e-38 131.3 1.0 4.7e-38 130.7 1.0 1.3 1 0 0 1 1 1 1 START domain PH_8 PF15409.6 CDW54254.1 - 7.4e-10 39.0 0.0 1.8e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CDW54254.1 - 8.2e-09 35.9 0.0 2.3e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CDW54254.1 - 8.5e-05 22.9 1.9 0.0078 16.6 0.9 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain TPT PF03151.16 CDW54255.1 - 5.1e-06 26.0 9.6 1.9e-05 24.1 9.6 2.0 1 1 0 1 1 1 1 Triose-phosphate Transporter family Phage_holin_2_1 PF04971.12 CDW54255.1 - 0.033 14.2 1.2 0.033 14.2 1.2 3.3 4 0 0 4 4 4 0 Bacteriophage P21 holin S Trypsin PF00089.26 CDW54256.1 - 1.8e-06 27.9 0.0 5.3e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 Trypsin Trypsin PF00089.26 CDW54257.1 - 2.2e-23 83.3 0.0 3.2e-07 30.4 0.0 3.5 3 0 0 3 3 3 3 Trypsin IPK PF03770.16 CDW54259.1 - 6.3e-53 179.6 0.0 9.2e-53 179.0 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase MORN PF02493.20 CDW54260.1 - 2.5e-33 112.0 71.0 1.5e-05 24.6 0.3 8.7 9 0 0 9 9 9 8 MORN repeat VWA PF00092.28 CDW54261.1 - 2.9e-42 144.9 3.7 1.1e-23 84.4 0.0 3.3 3 1 0 3 3 3 3 von Willebrand factor type A domain VWA_2 PF13519.6 CDW54261.1 - 1.5e-21 77.1 0.1 1.4e-10 41.7 0.0 3.4 3 0 0 3 3 3 3 von Willebrand factor type A domain VWA_3 PF13768.6 CDW54261.1 - 0.009 16.0 2.3 0.51 10.3 0.0 3.3 3 2 1 4 4 4 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 CDW54261.1 - 0.036 13.4 0.4 1.5 8.2 0.0 2.7 3 0 0 3 3 3 0 VWA domain containing CoxE-like protein NOG1 PF06858.14 CDW54261.1 - 0.07 12.9 0.1 3.9 7.3 0.1 2.6 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) Ral PF11058.8 CDW54261.1 - 0.15 11.6 0.1 0.96 9.1 0.1 2.1 2 0 0 2 2 2 0 Antirestriction protein Ral 7TM_GPCR_Srw PF10324.9 CDW54262.1 - 2e-08 33.9 15.2 2.9e-08 33.4 15.2 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW54262.1 - 2.8e-08 33.4 16.1 4.7e-08 32.7 14.8 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW54262.1 - 4.6e-05 23.2 13.9 4.6e-05 23.2 13.9 2.0 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF996 PF06195.13 CDW54262.1 - 3.8 7.8 11.3 2.2 8.6 3.3 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF996) GSH_synth_ATP PF03917.17 CDW54263.1 - 7.6e-192 637.1 0.0 2.5e-103 345.8 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CDW54263.1 - 4.6e-43 145.9 0.0 4.8e-21 75.2 0.0 3.4 3 0 0 3 3 3 2 Eukaryotic glutathione synthase Peptidase_C14 PF00656.22 CDW54263.1 - 2e-34 119.6 0.0 4.6e-34 118.5 0.0 1.5 1 1 0 1 1 1 1 Caspase domain CARD PF00619.21 CDW54263.1 - 1.7e-07 31.1 0.1 5.4e-07 29.6 0.1 1.9 1 0 0 1 1 1 1 Caspase recruitment domain RACo_C_ter PF14574.6 CDW54263.1 - 0.01 14.9 0.2 0.73 8.8 0.1 2.4 2 0 0 2 2 2 0 C-terminal domain of RACo the ASKHA domain RFC1 PF08519.12 CDW54263.1 - 0.038 14.2 0.1 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 Replication factor RFC1 C terminal domain C2 PF00168.30 CDW54264.1 - 3.4e-09 36.9 0.1 6.9e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 CDW54265.1 - 1.5e-38 131.2 0.0 2.2e-19 69.6 0.0 2.4 2 0 0 2 2 2 2 C2 domain PI31_Prot_N PF11566.8 CDW54265.1 - 0.0043 16.9 0.0 0.0073 16.1 0.0 1.3 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal SLAC1 PF03595.17 CDW54267.1 - 0.005 16.2 0.5 0.0061 15.9 0.5 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel PIRT PF15099.6 CDW54267.1 - 0.031 13.9 0.1 0.034 13.7 0.1 1.2 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family TMEM174 PF15029.6 CDW54267.1 - 0.11 12.2 0.1 0.13 12.0 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 174 NIF PF03031.18 CDW54268.1 - 3.8e-22 78.7 0.1 2.2e-21 76.3 0.0 2.1 2 1 1 3 3 3 1 NLI interacting factor-like phosphatase NES_C_h PF18208.1 CDW54268.1 - 0.18 12.1 0.3 15 5.9 0.0 2.7 3 0 0 3 3 3 0 Nicking enzyme C-terminal middle helical domain CwfJ_C_1 PF04677.15 CDW54269.1 - 6.9e-33 113.1 0.2 1.8e-32 111.8 0.1 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 CDW54269.1 - 5.1e-11 43.3 0.0 1.5e-10 41.8 0.0 1.8 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 DUF4187 PF13821.6 CDW54269.1 - 2.4e-10 40.0 1.3 5e-09 35.8 1.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch_2 PF12656.7 CDW54269.1 - 0.00052 20.1 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 CDW54269.1 - 0.00057 19.7 0.3 0.002 18.0 0.3 2.0 1 1 0 1 1 1 1 G-patch domain AKAP_110 PF05716.13 CDW54269.1 - 0.39 8.9 1.6 0.6 8.3 1.6 1.1 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) TFIIE_alpha PF02002.17 CDW54270.1 - 1.1e-19 70.2 0.5 2e-19 69.4 0.5 1.4 1 0 0 1 1 1 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 CDW54270.1 - 2.3e-16 59.9 5.1 4.7e-16 58.9 5.1 1.5 1 0 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha Herpes_glycoH_C PF17488.2 CDW54270.1 - 0.072 12.9 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus glycoprotein H C-terminal domain zf-C2HE PF16278.5 CDW54270.1 - 1.5 9.3 5.9 1.5 9.3 0.8 2.9 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger AMP-binding PF00501.28 CDW54271.1 - 2.8e-70 237.1 0.0 3.2e-70 236.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW54271.1 - 5.4e-05 24.1 0.0 0.00014 22.8 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SH3_2 PF07653.17 CDW54271.1 - 0.013 15.2 0.0 3.9 7.2 0.0 2.5 2 0 0 2 2 2 0 Variant SH3 domain RNF220 PF15926.5 CDW54274.1 - 6e-06 26.1 15.0 6e-05 22.8 13.6 2.3 1 1 1 2 2 2 1 E3 ubiquitin-protein ligase RNF220 Surp PF01805.20 CDW54275.1 - 7.6e-18 64.2 0.0 1.7e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 CDW54275.1 - 7.5e-10 38.5 0.0 2.1e-09 37.0 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.12 CDW54275.1 - 0.00011 22.3 1.1 0.00011 22.3 1.1 2.7 3 0 0 3 3 3 1 cwf21 domain CTD_bind PF04818.13 CDW54275.1 - 0.00016 22.4 0.2 0.00049 20.9 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. WRW PF10206.9 CDW54275.1 - 0.1 13.0 0.1 0.3 11.5 0.1 1.7 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f RRM_7 PF16367.5 CDW54275.1 - 0.13 12.4 0.0 0.52 10.5 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif mTERF PF02536.14 CDW54277.1 - 5.7e-17 61.6 0.0 1.7e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 mTERF DUF1713 PF08213.11 CDW54277.1 - 0.28 11.1 3.7 0.56 10.2 3.7 1.4 1 0 0 1 1 1 0 Mitochondrial domain of unknown function (DUF1713) Ku PF02735.16 CDW54278.1 - 3.8e-21 75.7 0.0 6.3e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 CDW54278.1 - 8.5e-20 71.1 0.1 1.8e-19 70.1 0.1 1.6 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.15 CDW54278.1 - 4.8e-17 62.5 0.0 1e-16 61.4 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 CDW54278.1 - 0.0013 19.4 0.1 0.0033 18.1 0.1 1.6 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm VWA_2 PF13519.6 CDW54278.1 - 0.052 14.2 0.0 0.13 13.0 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain F5_F8_type_C PF00754.25 CDW54279.1 - 1.9e-22 79.7 0.0 9.8e-20 71.0 0.0 2.5 2 0 0 2 2 2 2 F5/8 type C domain Tmemb_185A PF10269.9 CDW54280.1 - 1.4e-09 38.1 6.2 2e-09 37.5 6.2 1.3 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein Ndc1_Nup PF09531.10 CDW54280.1 - 3 6.4 8.1 3.4 6.2 8.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup IRS PF02174.17 CDW54281.1 - 1.3e-15 57.1 0.0 2.8e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 CDW54281.1 - 5.6e-05 23.6 1.9 8.4e-05 23.0 0.0 2.3 3 0 0 3 3 3 1 PH domain ABC_tran PF00005.27 CDW54282.1 - 3.6e-47 160.3 0.0 2.6e-28 99.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CDW54282.1 - 4.5e-39 134.7 24.8 9.9e-23 81.1 8.0 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CDW54282.1 - 9.7e-09 35.0 2.0 0.00088 18.8 0.0 4.3 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDW54282.1 - 6.5e-05 22.9 0.5 0.27 11.1 0.0 2.7 2 1 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CDW54282.1 - 0.00015 21.4 0.1 0.12 12.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain NB-ARC PF00931.22 CDW54282.1 - 0.00021 20.6 0.0 0.016 14.4 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain MMR_HSR1 PF01926.23 CDW54282.1 - 0.00038 20.5 0.3 0.27 11.3 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 CDW54282.1 - 0.0004 20.9 0.8 0.21 12.1 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CDW54282.1 - 0.0018 18.1 2.0 1.5 8.6 0.1 3.1 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CDW54282.1 - 0.0028 17.9 0.7 1.3 9.3 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 CDW54282.1 - 0.0065 16.9 0.0 4.5 7.7 0.0 3.4 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 CDW54282.1 - 0.009 16.1 0.2 4.2 7.4 0.1 2.5 2 0 0 2 2 2 1 Dynamin family Roc PF08477.13 CDW54282.1 - 0.022 15.0 0.0 15 5.9 0.0 3.2 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 CDW54282.1 - 0.025 14.7 0.1 0.073 13.1 0.1 1.7 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_16 PF13191.6 CDW54282.1 - 0.038 14.4 0.1 5.9 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 CDW54282.1 - 0.065 12.8 1.7 6.1 6.4 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 CDW54282.1 - 0.068 12.5 0.3 0.21 10.9 0.1 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.12 CDW54282.1 - 0.17 11.8 1.6 19 5.1 0.1 3.4 4 0 0 4 4 4 0 NACHT domain Patched PF02460.18 CDW54283.1 - 3.8e-196 653.7 6.3 4.4e-196 653.5 6.3 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW54283.1 - 1.7e-35 122.1 3.0 1.7e-35 122.1 3.0 2.4 2 1 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation Helicase_C_2 PF13307.6 CDW54284.1 - 3.6e-50 170.5 0.0 9.2e-50 169.1 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CDW54284.1 - 2.3e-44 151.1 4.5 4.1e-44 150.3 4.5 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 CDW54284.1 - 7.3e-06 26.1 0.0 0.0066 16.5 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 CDW54284.1 - 9.9e-06 25.4 0.0 0.0033 17.2 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase HBB PF06777.11 CDW54284.1 - 0.00058 19.6 0.1 0.0048 16.6 0.0 2.5 3 0 0 3 3 3 1 Helical and beta-bridge domain PhoH PF02562.16 CDW54284.1 - 0.044 13.2 0.0 11 5.4 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 CDW54284.1 - 0.051 13.9 0.2 1.3 9.3 0.1 2.8 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 CDW54284.1 - 0.067 12.2 0.0 0.14 11.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Proteasom_Rpn13 PF04683.13 CDW54285.1 - 1.4e-31 108.8 0.1 2.5e-31 108.1 0.1 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 CDW54285.1 - 6.8e-19 68.1 0.0 1.3e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 UCH-binding domain FERM_C PF09380.10 CDW54286.1 - 8.2e-23 80.6 0.1 1.6e-22 79.7 0.1 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain DUF3338 PF11819.8 CDW54286.1 - 9.5e-22 77.4 1.0 9.5e-22 77.4 1.0 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF3338) FERM_M PF00373.18 CDW54286.1 - 2e-17 63.7 0.7 5.8e-17 62.2 0.0 2.1 2 0 0 2 2 2 1 FERM central domain FERM_N PF09379.10 CDW54286.1 - 4.8e-08 32.8 0.1 1.2e-07 31.6 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain MFS_1 PF07690.16 CDW54287.1 - 7.1e-41 140.3 38.5 1.9e-24 86.2 12.3 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily ILEI PF15711.5 CDW54288.1 - 2.1e-22 79.4 0.1 3e-22 78.9 0.1 1.2 1 0 0 1 1 1 1 Interleukin-like EMT inducer Herpes_UL37_1 PF03970.13 CDW54288.1 - 0.19 10.9 0.0 0.26 10.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL37 tegument protein COX5B PF01215.19 CDW54289.1 - 1.6e-07 31.1 0.1 1.7e-07 31.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb SEFIR PF08357.11 CDW54290.1 - 5.5e-10 39.7 0.1 9.5e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 SEFIR domain SdrD_B PF17210.3 CDW54290.1 - 0.051 13.8 0.0 0.1 12.9 0.0 1.4 1 0 0 1 1 1 0 SdrD B-like domain UPF0113 PF03657.13 CDW54290.1 - 0.082 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 UPF0113 PUA domain DnaJ PF00226.31 CDW54291.1 - 2e-14 53.4 0.1 2.8e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 DnaJ domain DUF4148 PF13663.6 CDW54291.1 - 0.068 13.4 1.2 0.11 12.7 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) DRMBL PF07522.14 CDW54292.1 - 8.3e-23 80.7 0.0 1.7e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 CDW54292.1 - 2.7e-07 30.3 0.0 4.7e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RMMBL PF07521.12 CDW54292.1 - 0.034 14.1 0.0 0.086 12.8 0.0 1.6 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Ehbp PF10622.9 CDW54292.1 - 0.34 11.0 1.0 1.1 9.3 0.2 2.3 3 1 0 3 3 3 0 Energy-converting hydrogenase B subunit P (EhbP) Meis_PKNOX_N PF16493.5 CDW54294.1 - 2.9e-41 139.7 0.1 4.7e-41 139.0 0.1 1.3 1 0 0 1 1 1 1 N-terminal of Homeobox Meis and PKNOX1 Homeobox_KN PF05920.11 CDW54294.1 - 7.8e-13 48.1 1.4 1.9e-12 46.9 1.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 CDW54294.1 - 0.00019 21.2 0.1 0.00033 20.4 0.1 1.4 1 0 0 1 1 1 1 Homeodomain KNOX1 PF03790.13 CDW54294.1 - 0.049 13.4 0.1 3.9 7.3 0.0 2.4 2 0 0 2 2 2 0 KNOX1 domain Lactamase_B PF00753.27 CDW54295.1 - 7.8e-21 75.0 0.1 1.2e-20 74.4 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily ACPS PF01648.20 CDW54295.1 - 3.1e-15 56.3 0.0 1.1e-13 51.3 0.0 2.7 3 0 0 3 3 3 1 4'-phosphopantetheinyl transferase superfamily tRNA_int_endo PF01974.17 CDW54295.1 - 3.1e-14 52.8 0.3 1.7e-12 47.2 0.2 2.6 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain BLACT_WH PF17778.1 CDW54295.1 - 1.2e-08 34.8 0.0 2.8e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 CDW54295.1 - 0.0025 17.3 0.2 0.0051 16.4 0.2 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain XAP5 PF04921.14 CDW54295.1 - 2.1 8.1 6.0 3.6 7.3 6.0 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator PC_rep PF01851.22 CDW54296.1 - 1.7e-31 107.1 27.0 8.4e-06 26.0 0.1 9.6 9 0 0 9 9 9 7 Proteasome/cyclosome repeat RPN2_C PF18004.1 CDW54296.1 - 1.6e-30 106.1 15.8 1.6e-21 76.9 2.9 3.2 2 1 1 3 3 3 2 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_2 PF13646.6 CDW54296.1 - 2.9e-19 69.3 1.1 1.6e-11 44.4 0.0 6.2 4 1 5 9 9 9 2 HEAT repeats HEAT PF02985.22 CDW54296.1 - 2.6e-08 33.4 0.6 1.3 9.5 0.1 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 CDW54296.1 - 1e-06 29.1 0.1 0.56 10.8 0.0 4.5 3 1 0 3 3 3 2 HEAT-like repeat Cnd1 PF12717.7 CDW54296.1 - 0.001 19.1 0.5 5.6 7.0 0.0 4.0 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Gcn1_N PF12074.8 CDW54296.1 - 0.0065 15.8 1.3 0.7 9.1 0.2 3.5 4 0 0 4 4 4 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Uso1_p115_head PF04869.14 CDW54296.1 - 0.093 11.9 0.0 7 5.7 0.0 2.6 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, head region CCDC53 PF10152.9 CDW54296.1 - 0.23 11.9 6.3 1.9 8.9 2.0 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF4678 PF15727.5 CDW54296.1 - 0.29 10.4 8.2 2.1 7.5 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4678) Trypsin PF00089.26 CDW54297.1 - 2.1e-61 207.6 0.0 2.8e-61 207.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 CDW54297.1 - 5.6e-05 23.0 0.5 0.00012 22.0 0.5 1.5 1 0 0 1 1 1 1 PAN domain Peptidase_S6 PF02395.16 CDW54297.1 - 0.2 9.7 0.0 0.25 9.3 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin A1 protease TUDOR PF00567.24 CDW54298.1 - 3.4e-17 62.6 0.1 8.8e-17 61.3 0.0 1.7 2 0 0 2 2 2 1 Tudor domain SAM_PNT PF02198.16 CDW54298.1 - 0.002 18.1 0.1 0.0035 17.3 0.1 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain ATG7_N PF16420.5 CDW54299.1 - 2e-48 165.6 0.0 6.2e-48 164.0 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 CDW54299.1 - 4.3e-37 127.8 0.0 7.9e-37 126.9 0.0 1.3 1 0 0 1 1 1 1 ThiF family HA2 PF04408.23 CDW54299.1 - 6e-19 68.3 0.1 1.1e-18 67.4 0.1 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDW54299.1 - 1.7e-15 57.3 0.0 8.4e-15 55.1 0.0 2.2 2 1 1 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CDW54299.1 - 2.5e-05 24.6 0.0 5e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 CDW54299.1 - 0.0015 18.8 0.1 0.0064 16.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CDW54299.1 - 0.02 15.4 0.0 0.049 14.2 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Helicase_RecD PF05127.14 CDW54299.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Helicase PI3_PI4_kinase PF00454.27 CDW54300.1 - 3.5e-32 112.2 0.0 4.4e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SAC3_GANP PF03399.16 CDW54301.1 - 1.6e-71 241.1 1.5 1.8e-71 240.9 1.5 1.0 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CDW54301.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family MIF4G PF02854.19 CDW54302.1 - 7.1e-08 32.3 0.7 9.5e-07 28.7 0.7 2.2 1 1 0 1 1 1 1 MIF4G domain C2 PF00168.30 CDW54303.1 - 1.6e-15 57.2 0.0 3.3e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 CDW54303.1 - 9.3e-09 35.0 0.0 2e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW54303.1 - 3.7e-07 30.4 0.4 7.8e-07 29.4 0.4 1.6 1 0 0 1 1 1 1 PDZ domain SIR2 PF02146.17 CDW54305.1 - 1e-45 155.8 0.0 1.3e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Sir2 family zf-ribbon_3 PF13248.6 CDW54305.1 - 0.081 12.4 0.2 0.61 9.6 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain EAP30 PF04157.16 CDW54306.1 - 3.4e-29 101.8 0.1 3.9e-29 101.6 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family HSP90 PF00183.18 CDW54307.1 - 6.3e-226 751.3 21.3 8e-226 750.9 21.3 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CDW54307.1 - 2.1e-13 50.8 0.0 5.5e-13 49.4 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDW54307.1 - 2.3e-10 40.5 0.0 2.3e-10 40.5 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CobT PF06213.12 CDW54307.1 - 4.2 6.7 12.0 14 5.0 10.2 2.3 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT TMC PF07810.13 CDW54308.1 - 3.5e-31 108.1 4.9 3.5e-31 108.1 4.9 4.7 5 1 0 5 5 5 1 TMC domain HemY_N PF07219.13 CDW54308.1 - 0.067 13.4 0.2 0.64 10.2 0.0 2.9 2 0 0 2 2 2 0 HemY protein N-terminus DUF4064 PF13273.6 CDW54308.1 - 3 8.2 7.3 7.7 6.9 0.2 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF4064) C12orf66_like PF09404.10 CDW54309.1 - 1e-73 248.7 0.1 1.2e-73 248.4 0.1 1.0 1 0 0 1 1 1 1 KICSTOR complex C12orf66 like SPT2 PF08243.11 CDW54310.1 - 1.4e-18 67.4 19.8 2.1e-18 66.9 19.8 1.1 1 0 0 1 1 1 1 SPT2 chromatin protein MRP-L20 PF12824.7 CDW54310.1 - 0.00041 20.5 0.5 0.00047 20.4 0.5 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 CNDH2_C PF16858.5 CDW54310.1 - 0.0011 18.9 0.8 0.0011 18.9 0.8 1.6 1 1 1 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term RR_TM4-6 PF06459.12 CDW54310.1 - 0.024 14.5 2.2 0.029 14.2 2.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AAA_17 PF13207.6 CDW54310.1 - 0.026 14.9 1.8 0.031 14.7 0.4 1.7 2 0 0 2 2 2 0 AAA domain bPH_2 PF03703.14 CDW54310.1 - 0.052 13.7 0.6 3.8 7.8 0.1 2.6 2 1 1 3 3 3 0 Bacterial PH domain PNP_UDP_1 PF01048.20 CDW54311.1 - 3.1e-31 108.5 0.0 3.4e-31 108.3 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Band_7 PF01145.25 CDW54314.1 - 9.4e-32 110.4 0.3 1.2e-31 110.1 0.3 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CDW54314.1 - 0.009 15.7 0.1 0.012 15.3 0.1 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family DUF2710 PF10921.8 CDW54314.1 - 0.069 13.6 0.1 0.16 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2710) tRNA-synt_1 PF00133.22 CDW54315.1 - 1.6e-196 654.1 0.6 1.5e-114 383.5 0.0 3.3 2 1 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDW54315.1 - 1.5e-38 132.2 0.0 1.5e-38 132.2 0.0 1.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 CDW54315.1 - 2.8e-11 43.3 8.5 1.2e-09 38.0 0.0 3.4 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 CDW54315.1 - 9e-10 37.8 6.7 0.00064 18.6 0.0 5.1 6 1 0 6 6 6 3 tRNA synthetases class I (M) Jag_N PF14804.6 CDW54315.1 - 0.0075 16.6 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 Jag N-terminus tRNA-synt_1e PF01406.19 CDW54315.1 - 0.11 11.8 0.0 0.11 11.8 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain PIEZO PF15917.5 CDW54315.1 - 0.15 11.5 6.3 0.26 10.7 6.3 1.3 1 0 0 1 1 1 0 Piezo BrnA_antitoxin PF14384.6 CDW54315.1 - 0.97 10.0 0.0 0.97 10.0 0.0 2.5 2 0 0 2 2 2 0 BrnA antitoxin of type II toxin-antitoxin system Proteasome PF00227.26 CDW54316.1 - 5.6e-47 159.7 0.0 6.6e-47 159.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Band_7 PF01145.25 CDW54317.1 - 7.2e-11 42.4 4.4 1.1e-05 25.5 2.4 2.2 1 1 1 2 2 2 2 SPFH domain / Band 7 family Bact_transglu_N PF08379.10 CDW54317.1 - 0.017 16.0 0.2 2.8 8.9 0.0 2.4 2 0 0 2 2 2 0 Bacterial transglutaminase-like N-terminal region GP68 PF17469.2 CDW54317.1 - 0.13 12.7 1.3 0.28 11.6 0.9 1.8 1 1 1 2 2 2 0 Phage protein Gp68 LRR_4 PF12799.7 CDW54318.1 - 3.3e-06 27.3 17.9 0.013 15.9 0.2 5.4 5 1 0 5 5 5 3 Leucine Rich repeats (2 copies) F-box PF00646.33 CDW54318.1 - 0.065 13.1 0.3 0.34 10.8 0.0 2.4 2 0 0 2 2 2 0 F-box domain LRR_1 PF00560.33 CDW54318.1 - 0.15 12.7 8.6 3.8 8.4 0.1 4.7 4 1 0 4 4 4 0 Leucine Rich Repeat ERO1 PF04137.15 CDW54319.1 - 1.4e-113 379.7 0.4 1.6e-113 379.5 0.4 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) 2_5_RNA_ligase2 PF13563.6 CDW54319.1 - 0.088 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily HAUS-augmin3 PF14932.6 CDW54320.1 - 0.0013 18.3 5.1 0.0013 18.3 5.1 13.6 7 3 6 14 14 14 2 HAUS augmin-like complex subunit 3 DUF2779 PF11074.8 CDW54320.1 - 0.065 13.7 3.7 0.099 13.1 0.2 3.4 2 0 0 2 2 2 0 Domain of unknown function(DUF2779) MBOAT PF03062.19 CDW54321.1 - 9.7e-16 58.0 32.9 1.1e-15 57.9 31.7 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Holin_SPP1 PF04688.13 CDW54321.1 - 0.035 14.3 0.7 8.9 6.6 0.1 2.8 2 0 0 2 2 2 0 SPP1 phage holin CN_hydrolase PF00795.22 CDW54322.1 - 4.2e-50 170.5 0.0 4.3e-49 167.2 0.0 1.9 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Y_phosphatase PF00102.27 CDW54323.1 - 6.4e-163 539.8 0.3 2.5e-82 276.0 0.0 2.4 2 0 0 2 2 2 2 Protein-tyrosine phosphatase fn3 PF00041.21 CDW54323.1 - 2.6e-102 335.3 38.1 1.3e-16 60.7 0.1 10.1 9 1 0 9 9 9 9 Fibronectin type III domain Ig_3 PF13927.6 CDW54323.1 - 7.7e-29 100.1 2.5 9e-15 55.1 0.0 5.3 5 0 0 5 5 4 3 Immunoglobulin domain I-set PF07679.16 CDW54323.1 - 1.4e-28 98.8 0.0 2.3e-15 56.4 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 CDW54323.1 - 3e-19 69.4 24.7 0.0012 19.4 0.1 9.7 9 2 0 9 9 9 4 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 CDW54323.1 - 1.5e-17 63.7 0.7 1.2e-09 38.4 0.0 4.0 4 0 0 4 4 3 2 Immunoglobulin domain ig PF00047.25 CDW54323.1 - 2.7e-17 62.7 0.1 2.9e-10 40.2 0.0 3.2 3 0 0 3 3 2 2 Immunoglobulin domain Interfer-bind PF09294.10 CDW54323.1 - 6.2e-12 45.8 1.2 0.03 14.6 0.0 7.2 7 0 0 7 7 7 1 Interferon-alpha/beta receptor, fibronectin type III DSPc PF00782.20 CDW54323.1 - 8.4e-10 38.6 0.1 0.00071 19.4 0.0 2.7 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain V-set PF07686.17 CDW54323.1 - 5.1e-08 33.1 0.8 0.00027 21.1 0.1 4.4 3 1 0 3 3 3 1 Immunoglobulin V-set domain Y_phosphatase3 PF13350.6 CDW54323.1 - 1.5e-07 31.7 0.0 0.012 15.6 0.0 2.3 2 0 0 2 2 2 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CDW54323.1 - 4.1e-06 27.0 0.0 0.047 13.8 0.0 2.9 2 0 0 2 2 2 2 Inositol hexakisphosphate DUF2369 PF10179.9 CDW54323.1 - 2.3e-05 24.7 2.3 11 6.4 0.0 6.3 6 0 0 6 6 6 0 Uncharacterised conserved protein (DUF2369) DUF4998 PF16389.5 CDW54323.1 - 0.0016 18.1 3.0 3.9 7.0 0.0 4.9 6 0 0 6 6 5 1 Domain of unknown function C2-set_2 PF08205.12 CDW54323.1 - 0.0035 17.4 0.7 12 6.1 0.0 3.6 3 0 0 3 3 3 0 CD80-like C2-set immunoglobulin domain Adeno_E3_CR2 PF02439.15 CDW54323.1 - 0.083 12.7 0.9 0.21 11.4 0.9 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Big_5 PF13205.6 CDW54323.1 - 0.69 10.6 7.3 8.3 7.2 0.2 4.5 5 0 0 5 5 4 0 Bacterial Ig-like domain NOA36 PF06524.12 CDW54323.1 - 5.2 6.3 10.3 9.2 5.5 10.3 1.3 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 CDW54323.1 - 5.4 7.4 8.6 12 6.4 8.6 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIF_alpha PF05793.12 CDW54323.1 - 8.2 4.9 9.1 13 4.2 9.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4604 PF15377.6 CDW54324.1 - 1.2e-14 55.1 2.5 1.3e-14 55.0 2.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) YscO-like PF16789.5 CDW54324.1 - 0.024 14.7 0.8 0.031 14.3 0.8 1.2 1 0 0 1 1 1 0 YscO-like protein Fasciclin PF02469.22 CDW54325.1 - 5.4e-50 168.9 0.0 1.3e-19 70.7 0.0 4.7 4 1 0 4 4 4 4 Fasciclin domain ARID PF01388.21 CDW54328.1 - 2.5e-12 47.3 0.2 4.1e-12 46.6 0.2 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf-B_box PF00643.24 CDW54329.1 - 0.00051 20.1 1.6 0.00091 19.3 1.6 1.4 1 0 0 1 1 1 1 B-box zinc finger NHL PF01436.21 CDW54330.1 - 1.3e-50 167.0 21.7 7.5e-09 35.2 1.3 7.7 7 0 0 7 7 7 7 NHL repeat Filamin PF00630.19 CDW54330.1 - 8.5e-09 36.2 0.0 2.3e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Filamin/ABP280 repeat SGL PF08450.12 CDW54330.1 - 3.9e-08 33.2 0.7 0.00014 21.6 0.1 4.0 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 CDW54330.1 - 1.4e-06 27.8 7.8 0.0091 15.2 0.1 3.9 1 1 1 4 4 4 2 6-bladed beta-propeller zf-B_box PF00643.24 CDW54330.1 - 0.00014 21.9 1.6 0.00047 20.3 1.6 1.9 1 0 0 1 1 1 1 B-box zinc finger Invasin_D3 PF09134.10 CDW54330.1 - 0.0019 18.5 0.0 0.0043 17.3 0.0 1.5 1 0 0 1 1 1 1 Invasin, domain 3 DUF4968 PF16338.5 CDW54330.1 - 0.073 13.4 0.2 1.3 9.3 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4968) SBBP PF06739.11 CDW54330.1 - 0.082 12.9 1.3 0.23 11.5 0.0 2.5 2 0 0 2 2 2 0 Beta-propeller repeat DUF4934 PF16288.5 CDW54330.1 - 0.083 12.8 0.0 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4934) Sugar_tr PF00083.24 CDW54331.1 - 3.3e-36 125.1 11.6 4.6e-36 124.7 11.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW54331.1 - 2.6e-26 92.4 31.8 1e-22 80.5 15.4 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily PEN-2 PF10251.9 CDW54331.1 - 0.052 14.0 0.8 0.18 12.2 0.8 1.9 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase DUF2614 PF11023.8 CDW54331.1 - 0.62 10.2 3.5 0.65 10.1 0.2 2.7 2 1 1 3 3 3 0 Zinc-ribbon containing domain Biopterin_H PF00351.21 CDW54332.1 - 9.6e-99 330.5 3.0 2.5e-98 329.2 3.0 1.5 1 1 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase CTD_bind PF04818.13 CDW54333.1 - 3e-12 47.2 0.2 2.2e-05 25.2 0.0 4.4 4 0 0 4 4 4 3 RNA polymerase II-binding domain. CTK3 PF12243.8 CDW54333.1 - 0.0037 17.3 0.2 0.23 11.4 0.1 2.7 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 DUF5327 PF17261.2 CDW54333.1 - 0.38 11.5 3.4 0.26 12.1 0.4 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5327) 4HBT_3 PF13622.6 CDW54334.1 - 1.4e-37 130.3 0.1 1.7e-37 130.0 0.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CDW54334.1 - 2.1e-11 43.8 1.5 1.7e-07 31.1 0.4 2.9 2 1 1 3 3 3 3 Acyl-CoA thioesterase Cyclin_N PF00134.23 CDW54335.1 - 0.00016 21.4 0.1 0.00025 20.8 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain OTU PF02338.19 CDW54337.1 - 2.6e-23 82.9 0.0 9.9e-23 81.0 0.0 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Lustrin_cystein PF14625.6 CDW54338.1 - 1.5e-40 137.3 103.1 1.7e-09 37.9 10.7 6.2 6 0 0 6 6 6 6 Lustrin, cysteine-rich repeated domain TGF_beta PF00019.20 CDW54339.1 - 2.2e-24 86.4 2.1 4.7e-24 85.4 2.1 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 CDW54339.1 - 1e-14 54.9 0.0 1.6e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide XPA_C PF05181.12 CDW54339.1 - 0.095 12.7 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 XPA protein C-terminus PBP PF01161.20 CDW54340.1 - 2.2e-05 24.8 0.0 5.6e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Smg8_Smg9 PF10220.9 CDW54341.1 - 1.5e-81 275.1 7.4 1e-50 173.1 4.9 2.9 2 1 0 2 2 2 2 Smg8_Smg9 CAP_GLY PF01302.25 CDW54342.1 - 3.4e-16 59.0 0.2 7.2e-16 58.0 0.2 1.6 1 0 0 1 1 1 1 CAP-Gly domain UPF0242 PF06785.11 CDW54343.1 - 0.0019 18.4 4.4 0.0019 18.4 4.4 2.2 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Flavodoxin_3 PF12641.7 CDW54343.1 - 0.012 15.3 0.4 0.012 15.3 0.4 2.1 2 0 0 2 2 2 0 Flavodoxin domain Cas_DxTHG PF09455.10 CDW54343.1 - 1.2 8.7 6.6 1.5 8.3 6.6 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family PspB PF06667.12 CDW54343.1 - 1.6 8.9 6.3 1.9 8.6 4.2 2.2 1 1 1 2 2 2 0 Phage shock protein B Med4 PF10018.9 CDW54343.1 - 3.6 7.2 17.7 88 2.7 17.6 2.5 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 RPA_C PF08784.11 CDW54344.1 - 1.3e-13 51.5 0.0 2.9e-13 50.4 0.0 1.6 1 1 0 1 1 1 1 Replication protein A C terminal RMI2 PF16100.5 CDW54344.1 - 0.025 14.4 0.0 0.039 13.8 0.0 1.3 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 tRNA_anti-codon PF01336.25 CDW54344.1 - 0.091 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Peptidase_M14 PF00246.24 CDW54345.1 - 4e-73 246.7 0.1 7.1e-73 245.9 0.1 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 CDW54345.1 - 5.9e-15 55.3 0.5 3.9e-14 52.7 0.1 2.4 3 0 0 3 3 3 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 CDW54345.1 - 0.0002 21.3 0.0 0.00044 20.2 0.0 1.6 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 CDW54345.1 - 0.019 14.0 0.1 0.036 13.1 0.1 1.4 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Amidinotransf PF02274.17 CDW54346.1 - 3.3e-23 82.3 0.0 3.9e-23 82.1 0.0 1.1 1 0 0 1 1 1 1 Amidinotransferase DUF211 PF02680.14 CDW54346.1 - 0.17 12.1 0.0 3.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 IP_trans PF02121.18 CDW54347.1 - 1.4e-100 336.0 2.6 1.2e-71 241.2 0.9 2.2 2 0 0 2 2 2 2 Phosphatidylinositol transfer protein DDHD PF02862.17 CDW54347.1 - 1.4e-23 84.2 0.2 6.9e-23 82.0 0.2 2.1 1 1 0 1 1 1 1 DDHD domain 7tm_1 PF00001.21 CDW54348.1 - 7.9e-71 238.5 8.0 1.2e-70 237.9 8.0 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 CDW54348.1 - 5.3e-05 23.1 12.8 0.0017 18.2 9.9 3.0 2 1 0 2 2 2 1 Olfactory receptor 7TM_GPCR_Srsx PF10320.9 CDW54348.1 - 0.00011 21.7 4.7 0.00011 21.7 4.7 2.6 2 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx ECSCR PF15820.5 CDW54348.1 - 0.084 12.7 2.7 10 6.0 0.0 2.7 3 0 0 3 3 3 0 Endothelial cell-specific chemotaxis regulator Transcrip_reg PF01709.20 CDW54349.1 - 4.6e-51 173.6 1.9 5.3e-51 173.4 1.9 1.0 1 0 0 1 1 1 1 Transcriptional regulator DUF384 PF04064.13 CDW54350.1 - 9.9e-21 73.4 0.2 2e-20 72.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF384) DUF383 PF04063.14 CDW54350.1 - 8.1e-12 45.2 0.0 1.4e-11 44.5 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF383) Sec7_N PF12783.7 CDW54350.1 - 0.037 13.9 0.4 1.6 8.6 0.1 2.8 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Citrate_synt PF00285.21 CDW54351.1 - 1.7e-103 346.5 0.0 2e-103 346.2 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Smr PF01713.21 CDW54351.1 - 0.062 13.7 0.2 0.16 12.4 0.0 1.8 2 0 0 2 2 2 0 Smr domain 7tm_1 PF00001.21 CDW54352.1 - 0.0007 19.0 14.8 0.001 18.5 14.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) SpoIIM PF01944.17 CDW54352.1 - 5.1 7.1 9.1 19 5.2 1.3 3.0 2 1 1 3 3 3 0 Stage II sporulation protein M FF PF01846.19 CDW54353.1 - 1.9e-32 111.2 14.8 2.4e-12 46.8 0.1 6.2 6 0 0 6 6 6 4 FF domain WW PF00397.26 CDW54353.1 - 2.3e-20 72.3 8.9 6e-11 42.2 0.8 2.5 2 0 0 2 2 2 2 WW domain Glyco_hyd_101C PF17451.2 CDW54353.1 - 0.00023 21.5 3.5 0.15 12.4 0.3 2.8 1 1 1 2 2 2 2 Glycosyl hydrolase 101 beta sandwich domain DUF3539 PF12058.8 CDW54353.1 - 0.3 11.3 5.0 0.3 11.2 0.3 2.9 2 2 0 2 2 2 0 Protein of unknown function (DUF3539) RhoGAP PF00620.27 CDW54354.1 - 5.7e-39 133.4 0.0 8.5e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain START PF01852.19 CDW54354.1 - 5.9e-19 68.3 0.1 9.3e-19 67.7 0.1 1.2 1 0 0 1 1 1 1 START domain Cpn10 PF00166.21 CDW54355.1 - 1.5e-26 92.3 0.1 1.8e-25 88.8 0.1 1.9 1 1 0 1 1 1 1 Chaperonin 10 Kd subunit eRF1_2 PF03464.15 CDW54356.1 - 3.8e-47 159.9 0.0 6.2e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CDW54356.1 - 5.2e-39 133.2 0.1 1e-38 132.3 0.1 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 CDW54356.1 - 7.6e-19 68.0 0.0 1.2e-18 67.3 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 CDW54356.1 - 1.4e-08 35.1 0.0 2e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 CDW54356.1 - 5.4e-08 33.2 0.0 8.4e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 HSP70 PF00012.20 CDW54357.1 - 8e-41 139.9 0.0 9.5e-41 139.7 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein BcrAD_BadFG PF01869.20 CDW54357.1 - 0.13 11.7 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family adh_short PF00106.25 CDW54358.1 - 1.3e-51 174.9 4.6 1.6e-51 174.5 4.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW54358.1 - 2.6e-45 154.8 5.9 3.2e-45 154.5 5.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW54358.1 - 2e-10 40.8 1.5 3.1e-10 40.3 1.5 1.3 1 0 0 1 1 1 1 KR domain PP2C PF00481.21 CDW54359.1 - 7.1e-73 245.4 0.0 1.1e-72 244.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 CDW54359.1 - 2.5e-22 79.1 0.1 7.4e-22 77.6 0.1 1.9 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.6 CDW54359.1 - 3.4e-06 26.8 0.0 8.3e-06 25.6 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C S-AdoMet_synt_N PF00438.20 CDW54359.1 - 0.12 13.1 0.2 0.31 11.8 0.2 1.6 1 0 0 1 1 1 0 S-adenosylmethionine synthetase, N-terminal domain EF-hand_1 PF00036.32 CDW54360.1 - 6.9e-16 56.5 4.5 7.1e-08 31.5 0.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDW54360.1 - 1e-15 56.2 2.6 1.1e-08 34.3 0.4 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 CDW54360.1 - 1.3e-15 57.6 0.4 9.3e-11 42.0 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CDW54360.1 - 2e-09 36.5 3.8 4.3e-07 29.1 0.0 3.6 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 CDW54360.1 - 4.8e-09 35.9 4.0 2.9e-05 23.8 0.5 3.6 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW54360.1 - 0.016 15.5 0.0 0.094 13.0 0.0 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CDW54360.1 - 0.02 15.2 0.1 0.32 11.4 0.1 2.5 3 0 0 3 3 3 0 EF-hand domain Caleosin PF05042.13 CDW54360.1 - 0.092 12.7 0.3 4.2 7.3 0.0 2.5 3 0 0 3 3 3 0 Caleosin related protein EFhand_Ca_insen PF08726.10 CDW54360.1 - 0.14 12.2 0.0 17 5.6 0.0 2.3 2 0 0 2 2 2 0 Ca2+ insensitive EF hand NCBP3 PF10309.9 CDW54361.1 - 4.5e-20 71.3 0.0 7.1e-20 70.6 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 CDW54361.1 - 0.0034 17.4 0.0 0.008 16.2 0.0 1.6 2 0 0 2 2 2 1 RNA binding domain RRM_1 PF00076.22 CDW54361.1 - 0.18 11.7 0.0 0.44 10.4 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EHN PF06441.12 CDW54362.1 - 5.5e-31 107.1 0.3 2.9e-30 104.8 0.2 2.0 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CDW54362.1 - 1.8e-14 54.0 0.0 2.6e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW54362.1 - 0.0034 18.0 0.0 0.0074 16.9 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDW54362.1 - 0.18 11.0 0.0 0.68 9.1 0.0 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Yos1 PF08571.10 CDW54363.1 - 2.1e-20 72.8 3.6 2.8e-20 72.4 3.6 1.2 1 0 0 1 1 1 1 Yos1-like Dickkopf_N PF04706.12 CDW54364.1 - 2.7e-10 40.6 82.7 0.0034 17.8 7.4 7.2 5 2 2 7 7 7 7 Dickkopf N-terminal cysteine-rich region EB PF01683.18 CDW54364.1 - 1.5e-06 28.3 86.0 0.26 11.6 6.0 8.0 2 2 6 8 8 8 8 EB module Toxin_23 PF08093.11 CDW54364.1 - 0.068 13.3 1.5 0.068 13.3 1.5 8.2 7 1 1 8 8 8 0 Magi 5 toxic peptide family LrgB PF04172.16 CDW54365.1 - 0.12 11.9 0.1 0.47 9.9 0.0 1.8 2 0 0 2 2 2 0 LrgB-like family GST_N_3 PF13417.6 CDW54367.1 - 1.9e-19 69.8 0.1 3.3e-19 69.1 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDW54367.1 - 3.1e-15 56.2 0.0 5.8e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDW54367.1 - 1.5e-14 54.0 0.1 3e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CDW54367.1 - 0.0021 18.2 0.5 0.0051 17.0 0.1 1.9 2 0 0 2 2 2 1 Glutaredoxin GST_N_4 PF17172.4 CDW54367.1 - 0.064 14.0 0.0 0.14 12.9 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 CDW54367.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDW54367.1 - 0.14 12.4 0.1 0.48 10.7 0.0 1.9 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain DUF1736 PF08409.11 CDW54367.1 - 0.57 10.2 3.2 18 5.4 0.5 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1736) Sprouty PF05210.13 CDW54368.1 - 1.6e-15 57.3 19.3 1.6e-15 57.3 19.3 4.0 3 1 0 3 3 3 1 Sprouty protein (Spry) WH1 PF00568.23 CDW54368.1 - 1.6e-05 24.8 0.2 0.00012 22.0 0.1 2.1 1 1 1 2 2 2 1 WH1 domain Innexin PF00876.18 CDW54369.1 - 6.2e-108 361.2 13.2 7.5e-108 360.9 13.2 1.1 1 0 0 1 1 1 1 Innexin Fibrinogen_C PF00147.18 CDW54370.1 - 1.1e-35 123.5 5.5 3.9e-31 108.6 0.6 2.2 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Ank_2 PF12796.7 CDW54372.1 - 6.2e-17 62.0 0.2 6.4e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW54372.1 - 1.8e-14 53.6 0.6 0.00083 19.6 0.1 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW54372.1 - 7.8e-14 50.4 0.6 0.031 14.8 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 CDW54372.1 - 1.7e-12 47.1 0.3 0.00042 20.6 0.2 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 CDW54372.1 - 2.9e-09 37.3 0.3 9e-06 26.1 0.0 3.5 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Death PF00531.22 CDW54372.1 - 4.5e-09 36.3 0.2 9.9e-09 35.3 0.2 1.6 1 0 0 1 1 1 1 Death domain PRODH PF18327.1 CDW54372.1 - 0.014 15.6 0.1 0.055 13.7 0.0 2.1 2 0 0 2 2 2 0 Proline utilization A proline dehydrogenase N-terminal domain HEM4 PF02602.15 CDW54372.1 - 0.055 12.8 0.1 0.073 12.4 0.1 1.2 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD Sacchrp_dh_NADP PF03435.18 CDW54372.1 - 0.11 12.7 0.2 0.2 11.9 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Leo1 PF04004.13 CDW54373.1 - 4.5e-42 143.7 0.0 1.1e-41 142.5 0.0 1.6 1 0 0 1 1 1 1 Leo1-like protein NPM1-C PF16276.5 CDW54373.1 - 0.045 13.7 0.3 2.2 8.3 0.0 2.5 2 0 0 2 2 2 0 Nucleophosmin C-terminal domain Calx-beta PF03160.14 CDW54373.1 - 1.1 9.4 4.0 11 6.2 0.1 3.4 4 0 0 4 4 4 0 Calx-beta domain 60KD_IMP PF02096.20 CDW54374.1 - 2.9e-07 30.6 0.0 8.2e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 60Kd inner membrane protein YkyA PF10368.9 CDW54375.1 - 0.12 12.1 5.7 0.26 10.9 3.2 2.3 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Ada3 PF10198.9 CDW54375.1 - 0.68 10.1 11.5 0.21 11.7 7.2 2.3 2 1 0 2 2 2 0 Histone acetyltransferases subunit 3 Ig_3 PF13927.6 CDW54376.1 - 2.5e-66 220.2 1.4 1.4e-11 44.8 0.0 7.2 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.16 CDW54376.1 - 4.9e-64 212.4 0.0 2.3e-13 50.0 0.0 7.5 8 0 0 8 8 7 6 Immunoglobulin I-set domain fn3 PF00041.21 CDW54376.1 - 8.3e-49 163.9 20.5 5.6e-13 49.0 0.0 6.5 6 0 0 6 6 6 5 Fibronectin type III domain Ig_2 PF13895.6 CDW54376.1 - 3.9e-46 155.3 0.1 1e-08 35.4 0.0 6.6 5 1 1 6 6 6 6 Immunoglobulin domain ig PF00047.25 CDW54376.1 - 4.3e-38 129.4 0.0 6.4e-08 32.7 0.0 7.0 7 0 0 7 7 7 6 Immunoglobulin domain V-set PF07686.17 CDW54376.1 - 7.8e-20 71.1 6.1 0.00013 22.1 0.1 9.7 6 5 0 6 6 6 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW54376.1 - 1.3e-08 34.8 0.1 0.81 9.8 0.0 4.9 5 0 0 5 5 5 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 CDW54376.1 - 1.4e-08 34.1 0.0 0.012 15.2 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Interfer-bind PF09294.10 CDW54376.1 - 1.4e-06 28.6 1.4 0.0025 18.1 0.5 4.2 4 0 0 4 4 4 1 Interferon-alpha/beta receptor, fibronectin type III Izumo-Ig PF16706.5 CDW54376.1 - 0.00063 19.8 0.1 36 4.5 0.0 4.8 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain Bravo_FIGEY PF13882.6 CDW54376.1 - 0.0027 19.0 0.1 0.0062 17.9 0.1 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region Pur_ac_phosph_N PF16656.5 CDW54376.1 - 0.0042 17.6 18.2 0.036 14.6 0.1 6.3 7 1 0 7 7 7 1 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 CDW54376.1 - 0.011 16.1 1.4 20 5.7 0.0 4.1 4 0 0 4 4 4 0 Uncharacterised conserved protein (DUF2369) Herpes_gE PF02480.16 CDW54376.1 - 0.11 11.2 1.8 5.6 5.6 0.0 3.4 4 0 0 4 4 4 0 Alphaherpesvirus glycoprotein E BTB PF00651.31 CDW54377.1 - 1.9e-28 98.9 6.2 5.5e-13 49.1 0.1 3.5 2 1 1 3 3 3 3 BTB/POZ domain Ank_2 PF12796.7 CDW54377.1 - 2.3e-07 31.3 0.0 8.8e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW54377.1 - 8.9e-06 26.2 0.0 2.7e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW54377.1 - 2e-05 24.8 0.0 6.2e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW54377.1 - 0.00013 22.1 0.1 0.0033 17.8 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat BACK PF07707.15 CDW54377.1 - 0.0088 16.1 0.4 0.0088 16.1 0.4 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch Ank PF00023.30 CDW54377.1 - 0.012 16.0 0.0 0.063 13.8 0.0 2.3 1 0 0 1 1 1 0 Ankyrin repeat Cystatin PF00031.21 CDW54377.1 - 0.044 14.1 0.0 33 4.8 0.0 3.4 3 0 0 3 3 3 0 Cystatin domain zf-C4 PF00105.18 CDW54378.1 - 4.7e-29 100.7 14.4 8.4e-29 99.8 14.4 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Arrestin_C PF02752.22 CDW54380.1 - 6.7e-16 59.0 0.1 5.2e-15 56.1 0.1 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CDW54380.1 - 1.2e-14 54.6 0.0 3.7e-12 46.5 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain IgG_binding_B PF01378.17 CDW54380.1 - 0.092 12.8 0.1 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 B domain GNAT_acetyltr_2 PF13718.6 CDW54381.1 - 3.4e-97 324.3 0.0 1.1e-96 322.7 0.0 1.8 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 CDW54381.1 - 1.7e-68 230.8 0.4 3.2e-68 230.0 0.4 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 CDW54381.1 - 6.3e-57 192.3 0.1 1.7e-56 190.9 0.0 1.8 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 CDW54381.1 - 1.6e-27 95.2 0.0 4.6e-27 93.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Acetyltransf_1 PF00583.25 CDW54381.1 - 0.004 17.4 0.0 0.0089 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family AAA_22 PF13401.6 CDW54381.1 - 0.0046 17.2 0.1 0.43 10.8 0.0 3.0 2 0 0 2 2 2 1 AAA domain Acetyltransf_7 PF13508.7 CDW54381.1 - 0.008 16.6 0.0 0.025 15.0 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AAA_30 PF13604.6 CDW54381.1 - 0.035 13.8 0.1 1.8 8.3 0.0 2.6 2 1 0 2 2 2 0 AAA domain DprA_WH PF17782.1 CDW54381.1 - 0.1 12.7 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 DprA winged helix domain BRICHOS PF04089.14 CDW54382.1 - 6.2e-11 42.4 0.0 2.6e-10 40.4 0.0 2.0 1 1 0 1 1 1 1 BRICHOS domain Glyco_transf_8 PF01501.20 CDW54383.1 - 2.7e-21 76.3 0.0 5.4e-19 68.8 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 8 HMG_box PF00505.19 CDW54384.1 - 1e-27 96.3 3.3 2.1e-27 95.3 3.3 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW54384.1 - 1.8e-10 41.3 1.7 3.5e-10 40.3 1.7 1.5 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.8 CDW54384.1 - 0.0061 17.6 2.7 0.03 15.4 0.0 2.8 2 1 0 2 2 2 1 SOX transcription factor VbhA PF18495.1 CDW54386.1 - 0.088 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Antitoxin VbhA Xpo1 PF08389.12 CDW54387.1 - 1.8e-15 57.3 2.1 1.8e-15 57.3 2.1 3.1 4 0 0 4 4 4 1 Exportin 1-like protein DUF4745 PF15923.5 CDW54387.1 - 3.2e-05 23.9 0.4 0.66 9.9 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4745) Lig_chan-Glu_bd PF10613.9 CDW54388.1 - 8.4e-51 171.0 0.0 2.2e-23 82.7 0.0 3.5 3 0 0 3 3 3 2 Ligated ion channel L-glutamate- and glycine-binding site Lig_chan PF00060.26 CDW54388.1 - 1.1e-19 70.8 0.0 9.1e-15 54.8 0.1 2.7 2 1 0 2 2 2 2 Ligand-gated ion channel SBP_bac_3 PF00497.20 CDW54388.1 - 1.9e-17 63.5 2.3 5.2e-06 26.0 0.0 4.9 5 0 0 5 5 5 3 Bacterial extracellular solute-binding proteins, family 3 Glyco_transf_88 PF16849.5 CDW54388.1 - 0.013 14.5 0.2 0.032 13.2 0.2 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 88 Arrestin_N PF00339.29 CDW54389.1 - 8.4e-35 120.0 0.0 4.8e-34 117.5 0.0 2.1 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CDW54389.1 - 2.7e-15 57.0 0.0 3.1e-11 43.9 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.15 CDW54389.1 - 6.9e-05 22.0 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Rgp1 PF08737.10 CDW54389.1 - 0.032 13.4 0.0 0.44 9.7 0.0 2.4 3 0 0 3 3 3 0 Rgp1 Spo0M PF07070.11 CDW54389.1 - 0.042 13.4 0.0 1.5 8.3 0.0 2.5 3 0 0 3 3 3 0 SpoOM protein Collagen PF01391.18 CDW54390.1 - 1.1e-21 76.3 97.4 2e-08 33.8 28.8 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW54390.1 - 1.4e-15 57.1 0.8 1.9e-15 56.7 0.8 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain EF-hand_7 PF13499.6 CDW54391.1 - 7e-06 26.4 0.2 8.4e-05 22.9 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CDW54391.1 - 0.0014 18.0 0.1 0.011 15.2 0.1 2.6 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 CDW54391.1 - 0.013 15.8 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_6 PF13405.6 CDW54391.1 - 0.032 14.1 0.2 0.5 10.4 0.1 2.8 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.6 CDW54391.1 - 0.078 12.8 0.2 0.66 9.9 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair Myosin_head PF00063.21 CDW54392.1 - 1.8e-128 429.7 10.7 2.8e-128 429.0 10.7 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) MyTH4 PF00784.17 CDW54392.1 - 7.9e-24 84.2 0.0 3.9e-23 82.0 0.0 2.3 1 0 0 1 1 1 1 MyTH4 domain IQ PF00612.27 CDW54392.1 - 7.9e-10 37.7 7.7 0.00029 20.4 0.6 2.8 2 0 0 2 2 2 2 IQ calmodulin-binding motif DUF866 PF05907.13 CDW54392.1 - 0.039 13.9 0.4 1.9 8.4 0.0 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF866) TsaE PF02367.17 CDW54392.1 - 0.048 13.7 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MyTH4 PF00784.17 CDW54393.1 - 5.7e-26 91.1 0.5 2.7e-25 89.0 0.0 2.4 2 1 0 2 2 2 1 MyTH4 domain SH3_2 PF07653.17 CDW54393.1 - 1.8e-07 30.7 0.0 5.1e-07 29.3 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CDW54393.1 - 6.3e-07 29.2 0.0 1.4e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW54393.1 - 7.3e-05 22.3 0.0 0.00013 21.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain RA PF00788.23 CDW54393.1 - 0.0083 16.7 0.2 0.018 15.6 0.2 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FERM_N PF09379.10 CDW54393.1 - 0.02 14.8 0.1 0.043 13.8 0.1 1.5 1 0 0 1 1 1 0 FERM N-terminal domain FERM_M PF00373.18 CDW54393.1 - 0.043 14.2 0.0 3.9 7.9 0.0 3.4 3 1 1 4 4 4 0 FERM central domain Homeodomain PF00046.29 CDW54394.1 - 1e-15 57.3 4.8 2.1e-10 40.3 0.0 2.3 2 0 0 2 2 2 2 Homeodomain Filament PF00038.21 CDW54395.1 - 3e-73 247.1 51.2 1.1e-70 238.8 51.2 2.2 1 1 0 1 1 1 1 Intermediate filament protein APG6_N PF17675.1 CDW54395.1 - 0.00043 20.8 61.8 0.63 10.6 13.8 5.6 1 1 5 6 6 6 5 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 CDW54395.1 - 0.00043 20.3 50.1 0.0007 19.6 15.3 4.3 2 2 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 CDW54395.1 - 0.0041 17.2 3.2 0.0041 17.2 3.2 5.5 1 1 6 7 7 7 5 TPR/MLP1/MLP2-like protein SOGA PF11365.8 CDW54395.1 - 0.0091 17.1 35.4 0.088 13.9 7.2 6.0 1 1 5 6 6 6 2 Protein SOGA YabA PF06156.13 CDW54395.1 - 0.017 15.8 37.4 0.56 10.9 7.0 5.7 1 1 4 5 5 5 0 Initiation control protein YabA Spc7 PF08317.11 CDW54395.1 - 0.033 13.1 45.4 0.14 11.1 10.5 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein COG2 PF06148.11 CDW54395.1 - 0.038 14.1 0.7 0.038 14.1 0.7 4.6 4 1 1 5 5 4 0 COG (conserved oligomeric Golgi) complex component, COG2 APOBEC4 PF18775.1 CDW54395.1 - 0.13 12.5 0.1 0.35 11.1 0.1 1.8 1 0 0 1 1 1 0 APOBEC4 UPF0242 PF06785.11 CDW54395.1 - 0.16 12.1 49.1 2.3 8.3 5.1 4.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus CCDC144C PF14915.6 CDW54395.1 - 0.28 10.3 47.9 0.012 14.8 7.9 3.8 1 1 2 3 3 3 0 CCDC144C protein coiled-coil region ADIP PF11559.8 CDW54395.1 - 0.33 11.0 45.2 0.15 12.1 8.4 4.9 1 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 CDW54395.1 - 0.41 9.7 36.3 0.29 10.2 7.5 3.3 1 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4600 PF15372.6 CDW54395.1 - 0.43 11.0 33.5 0.56 10.6 3.6 3.9 2 2 2 4 4 4 0 Domain of unknown function (DUF4600) ATG16 PF08614.11 CDW54395.1 - 0.68 10.1 56.3 0.4 10.9 24.2 4.3 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 CDW54395.1 - 0.88 10.0 50.0 1 9.8 7.8 3.6 1 1 1 3 3 3 0 Fez1 FlaC_arch PF05377.11 CDW54395.1 - 1.1 9.7 14.2 17 5.9 0.1 5.7 3 2 2 5 5 5 0 Flagella accessory protein C (FlaC) KASH_CCD PF14662.6 CDW54395.1 - 1.3 8.8 47.0 12 5.6 13.4 4.0 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF948 PF06103.11 CDW54395.1 - 1.8 8.9 9.1 2.4 8.5 0.0 4.3 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) Prominin PF05478.11 CDW54395.1 - 2.2 6.1 27.2 0.23 9.4 11.8 2.9 1 1 1 2 2 2 0 Prominin Prefoldin_2 PF01920.20 CDW54395.1 - 2.5 8.1 32.9 1.3 9.0 4.0 5.7 5 1 1 6 6 6 0 Prefoldin subunit FPP PF05911.11 CDW54395.1 - 2.7 6.1 39.4 0.041 12.1 14.9 2.3 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil TSC22 PF01166.18 CDW54395.1 - 3.1 8.2 25.0 0.3 11.4 1.5 6.0 4 1 2 6 6 6 0 TSC-22/dip/bun family Cep57_MT_bd PF06657.13 CDW54395.1 - 4 8.0 31.7 0.047 14.1 6.0 5.0 3 2 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 bZIP_1 PF00170.21 CDW54395.1 - 4 7.6 34.3 0.58 10.3 1.6 5.7 4 2 2 6 6 6 0 bZIP transcription factor DUF4407 PF14362.6 CDW54395.1 - 5.4 6.3 42.8 22 4.3 9.0 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF4407) MAD PF05557.13 CDW54395.1 - 7.6 4.8 51.5 0.73 8.1 10.2 3.1 1 1 2 3 3 3 0 Mitotic checkpoint protein CENP-H PF05837.12 CDW54395.1 - 9.7 6.6 40.6 0.93 9.9 5.7 5.1 1 1 1 4 4 4 0 Centromere protein H (CENP-H) Vps53_N PF04100.12 CDW54396.1 - 5e-92 308.8 6.0 5e-92 308.8 6.0 2.0 2 0 0 2 2 2 1 Vps53-like, N-terminal VPS53_C PF16854.5 CDW54396.1 - 5.9e-06 26.3 3.0 8.7e-05 22.5 0.0 3.2 3 0 0 3 3 3 1 Vacuolar protein sorting-associated protein 53 C-terminus Vps54_N PF10475.9 CDW54396.1 - 0.00011 21.6 7.0 0.00028 20.3 7.0 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 CDW54396.1 - 0.00036 20.4 1.8 0.0017 18.2 0.1 2.9 2 2 2 4 4 4 1 Protein of unknown function C-terminus (DUF2451) RPN6_N PF18055.1 CDW54396.1 - 0.062 13.7 4.2 0.23 11.8 0.0 3.1 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain COX6B PF02297.17 CDW54397.1 - 1.4e-16 60.4 8.2 1.7e-16 60.2 8.2 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CHCH PF06747.13 CDW54397.1 - 0.0002 21.4 1.4 0.0002 21.4 1.4 1.6 2 0 0 2 2 2 1 CHCH domain CX9C PF16860.5 CDW54397.1 - 0.0075 16.3 1.4 0.012 15.6 1.4 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, GDA1_CD39 PF01150.17 CDW54398.1 - 6.4e-111 371.0 0.0 9.6e-111 370.4 0.0 1.2 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family GDPD PF03009.17 CDW54399.1 - 2.9e-25 89.5 0.0 6.5e-25 88.3 0.0 1.5 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 CDW54399.1 - 0.0052 17.2 0.0 0.012 16.1 0.0 1.7 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Peptidase_M41 PF01434.18 CDW54400.1 - 4.4e-56 189.8 0.1 2.4e-55 187.4 0.2 2.1 3 0 0 3 3 3 1 Peptidase family M41 AAA PF00004.29 CDW54400.1 - 4.5e-37 127.4 0.0 8e-37 126.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW54400.1 - 1e-10 41.3 0.0 2.5e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDW54400.1 - 6.1e-05 23.0 0.0 0.00037 20.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW54400.1 - 0.00039 20.8 0.0 0.0014 19.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_2 PF07724.14 CDW54400.1 - 0.00041 20.5 0.0 0.0008 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 CDW54400.1 - 0.003 16.8 0.1 0.007 15.6 0.0 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 CDW54400.1 - 0.0052 17.1 0.0 0.29 11.4 0.0 3.2 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 CDW54400.1 - 0.0095 15.7 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 CDW54400.1 - 0.012 16.1 0.0 0.025 15.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDW54400.1 - 0.022 14.5 0.0 0.055 13.2 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDW54400.1 - 0.048 13.0 0.1 0.1 11.9 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CDW54400.1 - 0.1 13.1 0.0 0.44 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain DAGK_acc PF00609.19 CDW54401.1 - 8.3e-52 175.7 0.0 1.8e-51 174.7 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 CDW54401.1 - 2.1e-27 95.2 0.0 4.7e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DAG_kinase_N PF14513.6 CDW54401.1 - 6.3e-17 62.3 4.0 1.5e-15 57.8 4.0 2.4 1 1 0 1 1 1 1 Diacylglycerol kinase N-terminus C1_1 PF00130.22 CDW54401.1 - 9.8e-12 44.6 43.1 4e-08 33.0 17.7 2.7 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_6 PF13405.6 CDW54401.1 - 1.1e-07 31.2 0.0 0.0019 18.0 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CDW54401.1 - 2.6e-07 29.7 0.6 0.015 14.8 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CDW54401.1 - 7.1e-07 29.6 0.4 2.5e-06 27.8 0.4 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 CDW54401.1 - 0.00069 19.0 0.1 0.031 13.8 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 CDW54401.1 - 0.58 10.0 2.0 26 4.8 0.1 3.6 3 0 0 3 3 3 0 EF-hand domain pair Reprolysin PF01421.19 CDW54402.1 - 2.9e-27 95.9 1.2 2.9e-27 95.9 1.2 2.6 3 1 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Disintegrin PF00200.23 CDW54402.1 - 3.7e-08 34.1 30.7 2.5e-07 31.4 30.7 2.4 1 1 0 1 1 1 1 Disintegrin ADAM_CR PF08516.12 CDW54402.1 - 0.0001 22.6 3.9 0.0001 22.6 3.9 3.6 2 2 0 2 2 2 1 ADAM cysteine-rich Reprolysin_5 PF13688.6 CDW54402.1 - 0.0031 17.7 0.2 0.0074 16.5 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Tropomodulin PF03250.14 CDW54403.1 - 2.2e-55 186.6 2.0 4.2e-55 185.7 0.6 2.1 2 0 0 2 2 2 1 Tropomodulin DUF3007 PF11460.8 CDW54403.1 - 0.23 11.7 0.4 0.61 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) Peptidase_C1 PF00112.23 CDW54404.1 - 1.3e-62 211.7 0.5 1.3e-62 211.7 0.5 2.1 2 0 0 2 2 2 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 CDW54404.1 - 0.00016 20.6 1.4 0.0087 14.9 0.1 2.6 2 1 0 3 3 3 2 Peptidase C1-like family Somatomedin_B PF01033.17 CDW54404.1 - 0.0026 18.1 18.4 0.0084 16.5 18.4 1.9 1 0 0 1 1 1 1 Somatomedin B domain La PF05383.17 CDW54405.1 - 1.4e-19 69.8 0.2 2.3e-19 69.2 0.2 1.3 1 0 0 1 1 1 1 La domain zf-C4 PF00105.18 CDW54406.1 - 2.8e-30 104.6 17.2 2.8e-30 104.6 17.2 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW54406.1 - 1.9e-19 70.1 0.3 9.9e-19 67.7 0.3 2.0 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor GCP_C_terminal PF04130.13 CDW54407.1 - 1.1e-33 117.1 5.2 1.1e-33 117.1 5.2 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal MRG PF05712.13 CDW54407.1 - 5.8e-20 71.4 0.1 1.6e-19 70.0 0.1 1.7 1 0 0 1 1 1 1 MRG GCP_N_terminal PF17681.1 CDW54407.1 - 2.1e-19 70.3 3.9 4.8e-15 56.0 0.7 3.0 2 1 1 3 3 3 2 Gamma tubulin complex component N-terminal Tudor-knot PF11717.8 CDW54407.1 - 3.1e-07 30.2 2.2 8.6e-07 28.8 2.2 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Agenet PF05641.12 CDW54407.1 - 0.026 15.0 1.0 0.082 13.4 1.0 1.9 1 0 0 1 1 1 0 Agenet domain SPRY PF00622.28 CDW54408.1 - 2.1e-13 50.4 0.0 3.8e-13 49.6 0.0 1.4 1 1 0 1 1 1 1 SPRY domain SOCS_box PF07525.16 CDW54408.1 - 2.2e-10 40.7 6.5 3.8e-10 39.9 6.5 1.4 1 0 0 1 1 1 1 SOCS box DUF3523 PF12037.8 CDW54409.1 - 4.1e-84 282.1 25.0 4.1e-84 282.1 25.0 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3523) AAA PF00004.29 CDW54409.1 - 8.1e-12 45.7 0.4 3.8e-11 43.5 0.0 2.4 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW54409.1 - 4.8e-05 23.4 0.1 0.005 16.9 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDW54409.1 - 0.00076 18.9 0.1 0.0029 17.0 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CDW54409.1 - 0.00079 19.2 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CDW54409.1 - 0.017 14.9 0.1 0.097 12.4 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 CDW54409.1 - 0.029 14.6 2.9 1.8 8.8 0.0 3.5 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 CDW54409.1 - 0.048 13.4 0.0 0.14 11.9 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CDW54409.1 - 0.059 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 CDW54409.1 - 0.09 12.6 2.2 5.6 6.8 1.1 3.0 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW54409.1 - 0.23 11.9 0.0 0.23 11.9 0.0 2.8 2 2 1 3 3 2 0 AAA ATPase domain AAA_11 PF13086.6 CDW54409.1 - 0.45 10.3 0.0 0.45 10.3 0.0 2.9 2 1 1 3 3 3 0 AAA domain AAA_23 PF13476.6 CDW54409.1 - 6.9 7.1 0.0 6.9 7.1 0.0 2.9 2 1 0 2 2 1 0 AAA domain LIM PF00412.22 CDW54410.1 - 2.2e-24 85.4 23.1 6.2e-13 48.8 9.2 2.1 2 0 0 2 2 2 2 LIM domain Vps39_2 PF10367.9 CDW54410.1 - 0.65 10.5 12.3 8.2 6.9 0.5 3.4 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 2 zf-C3HC4_3 PF13920.6 CDW54410.1 - 3.9 7.4 31.4 7.7 6.5 7.5 3.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) LIM PF00412.22 CDW54411.1 - 8.2e-22 77.2 26.8 5.4e-13 49.0 5.6 2.1 2 0 0 2 2 2 2 LIM domain DUF2321 PF10083.9 CDW54411.1 - 2 8.0 18.7 0.088 12.4 5.0 2.8 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2H2 PF00096.26 CDW54412.1 - 3.7e-15 55.4 18.5 2e-05 24.8 2.8 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW54412.1 - 4.3e-13 49.0 4.2 7.4e-09 35.6 0.3 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW54412.1 - 8.5e-08 32.4 18.0 0.0044 17.7 1.6 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 CDW54412.1 - 0.0056 17.3 5.8 0.2 12.3 0.7 3.5 2 1 2 4 4 4 1 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 CDW54412.1 - 0.017 14.9 18.5 0.059 13.1 0.0 4.4 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 CDW54412.1 - 0.029 14.7 1.9 0.096 13.0 1.8 1.9 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-met PF12874.7 CDW54412.1 - 0.03 14.7 3.3 6.1 7.4 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW54412.1 - 0.03 14.6 1.0 0.26 11.6 0.0 2.7 3 0 0 3 3 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW54412.1 - 0.034 14.1 0.4 0.034 14.1 0.4 3.2 4 0 0 4 4 4 0 C2H2-type zinc finger Insulin PF00049.18 CDW54412.1 - 0.085 13.9 0.0 0.24 12.4 0.0 1.8 1 0 0 1 1 1 0 Insulin/IGF/Relaxin family zf-C2H2_11 PF16622.5 CDW54412.1 - 0.55 10.1 5.6 22 4.9 0.0 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 CDW54412.1 - 1 9.8 3.5 2.7 8.4 2.3 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) NAD_binding_1 PF00175.21 CDW54413.1 - 1.8e-12 47.9 0.0 5.1e-12 46.4 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain EB PF01683.18 CDW54413.1 - 4.9e-12 45.9 86.5 3.6e-06 27.2 7.4 9.2 3 2 6 9 9 9 6 EB module FAD_binding_6 PF00970.24 CDW54413.1 - 1.3e-06 28.6 0.0 2.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CDW54413.1 - 0.0016 18.6 0.0 0.0078 16.3 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain Dickkopf_N PF04706.12 CDW54413.1 - 0.014 15.8 2.1 0.014 15.8 2.1 9.8 6 2 4 10 10 10 0 Dickkopf N-terminal cysteine-rich region CXCXC PF03128.14 CDW54413.1 - 0.025 15.0 1.6 0.025 15.0 1.6 5.2 4 0 0 4 4 4 0 CXCXC repeat Cyt-b5 PF00173.28 CDW54414.1 - 9.8e-15 54.5 0.1 1.3e-14 54.1 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF1581 PF07619.11 CDW54414.1 - 0.04 14.1 0.0 7.1 6.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1581) bZIP_2 PF07716.15 CDW54415.1 - 1.9e-23 82.3 38.2 3e-14 52.8 11.3 2.6 2 0 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 CDW54415.1 - 5.4e-08 32.8 29.9 6.3e-05 23.0 13.1 2.4 2 0 0 2 2 2 2 bZIP transcription factor Fungal_TACC PF12709.7 CDW54415.1 - 0.051 14.0 3.3 0.24 11.9 0.7 2.5 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins bZIP_Maf PF03131.17 CDW54415.1 - 0.12 12.9 27.1 0.51 10.9 3.8 2.6 2 0 0 2 2 2 0 bZIP Maf transcription factor YabA PF06156.13 CDW54415.1 - 0.16 12.6 3.2 3.3 8.4 0.6 2.8 2 0 0 2 2 2 0 Initiation control protein YabA JIP_LZII PF16471.5 CDW54415.1 - 0.41 10.9 4.8 5.4 7.3 1.3 2.6 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II UPF0449 PF15136.6 CDW54415.1 - 1.5 9.4 6.4 1.3 9.5 4.0 2.1 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 PAN_4 PF14295.6 CDW54415.1 - 6.7 6.7 6.5 1.1 9.2 1.5 2.3 2 0 0 2 2 2 0 PAN domain DNA_pol_A_exo1 PF01612.20 CDW54416.1 - 4.5e-39 134.0 0.1 6.9e-39 133.4 0.1 1.3 1 0 0 1 1 1 1 3'-5' exonuclease HRDC PF00570.23 CDW54416.1 - 1.5e-08 34.5 0.1 3.6e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 HRDC domain MFS_1 PF07690.16 CDW54417.1 - 9.1e-33 113.6 42.5 1.2e-31 109.9 34.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW54417.1 - 7e-08 31.8 11.7 7e-08 31.8 11.7 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter MBOAT PF03062.19 CDW54419.1 - 2.9e-10 40.0 24.8 5.8e-10 39.0 24.8 1.5 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Gtr1_RagA PF04670.12 CDW54420.1 - 9.1e-102 339.3 0.9 1.1e-101 339.0 0.9 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 CDW54420.1 - 2.7e-09 36.7 0.0 5.7e-09 35.7 0.0 1.6 1 1 1 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 CDW54420.1 - 9.3e-09 35.5 0.0 4e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDW54420.1 - 1.6e-08 34.3 0.1 3.7e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 CDW54420.1 - 7.2e-06 26.1 0.0 1.7e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDW54420.1 - 0.00036 20.1 0.0 0.00097 18.7 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CDW54420.1 - 0.022 14.5 0.3 0.092 12.5 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 CDW54420.1 - 0.048 13.6 0.4 3.4 7.5 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase DEAD PF00270.29 CDW54420.1 - 0.064 13.0 0.0 0.08 12.7 0.0 1.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.6 CDW54420.1 - 0.064 13.0 0.1 0.14 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDW54420.1 - 0.089 13.3 0.0 0.24 11.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter G-alpha PF00503.20 CDW54420.1 - 0.93 8.6 6.5 7.6 5.6 0.2 2.9 3 1 0 3 3 3 0 G-protein alpha subunit Troponin PF00992.20 CDW54423.1 - 2.2e-07 31.2 6.9 2.2e-07 31.2 6.9 3.1 2 1 1 3 3 3 1 Troponin MCM_bind PF09739.9 CDW54423.1 - 3.6 5.9 15.9 7 5.0 15.9 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Zip PF02535.22 CDW54423.1 - 10 5.3 7.3 11 5.1 7.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ATP-synt_ab PF00006.25 CDW54425.1 - 2.3e-63 213.7 0.1 2.6e-62 210.3 0.0 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDW54425.1 - 4.4e-13 49.5 0.5 1.2e-12 48.2 0.2 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain DUF5535 PF17687.1 CDW54425.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5535) Utp12 PF04003.12 CDW54426.1 - 1e-13 51.5 0.3 2e-13 50.6 0.3 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 CDW54426.1 - 1e-07 32.5 9.6 0.057 14.3 0.5 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW54426.1 - 2.8e-07 30.7 0.1 2.7e-05 24.4 0.1 2.7 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain CAP PF00188.26 CDW54427.1 - 0.00056 20.7 0.1 0.0012 19.7 0.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Ion_trans PF00520.31 CDW54429.1 - 4.8e-206 681.0 92.6 6.2e-68 228.7 13.6 7.6 5 1 2 7 7 7 7 Ion transport protein PKD_channel PF08016.12 CDW54429.1 - 1.4e-08 33.8 0.9 1.4e-08 33.8 0.9 9.5 8 3 3 11 11 11 5 Polycystin cation channel DPM3 PF08285.11 CDW54429.1 - 0.38 11.0 13.4 0.11 12.7 0.3 4.4 4 0 0 4 4 4 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) FixH PF05751.11 CDW54429.1 - 0.48 10.4 1.4 8.4 6.4 1.0 2.9 2 0 0 2 2 2 0 FixH UPF0542 PF15086.6 CDW54429.1 - 1.2 9.1 6.0 16 5.5 0.2 3.7 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 Mito_carr PF00153.27 CDW54430.1 - 4.6e-66 218.8 0.1 1.4e-21 76.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CDW54430.1 - 0.12 11.5 0.1 1.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Gammaproteobacterial serine protease Sad1_UNC PF07738.13 CDW54431.1 - 8.3e-35 119.7 0.0 6.3e-34 116.8 0.0 2.1 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal CENP-F_leu_zip PF10473.9 CDW54431.1 - 0.23 11.5 1.7 0.41 10.7 1.7 1.4 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Kv2channel PF03521.14 CDW54432.1 - 0.018 14.4 0.1 0.038 13.4 0.1 1.5 1 1 0 1 1 1 0 Kv2 voltage-gated K+ channel TelA PF05816.11 CDW54432.1 - 0.046 12.8 0.6 0.052 12.6 0.6 1.1 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) DUF3398 PF11878.8 CDW54432.1 - 0.085 13.3 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) PI3_PI4_kinase PF00454.27 CDW54433.1 - 0.00033 20.5 0.2 0.00096 19.0 0.2 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase IBN_N PF03810.19 CDW54433.1 - 0.015 15.2 0.6 0.2 11.6 0.1 3.2 3 0 0 3 3 3 0 Importin-beta N-terminal domain FATC PF02260.20 CDW54433.1 - 0.18 11.7 4.7 0.048 13.5 0.4 2.4 3 0 0 3 3 3 0 FATC domain CBP4 PF07960.11 CDW54434.1 - 0.13 12.1 0.8 0.26 11.1 0.8 1.7 1 1 0 1 1 1 0 CBP4 Glycolytic PF00274.19 CDW54435.1 - 1.2e-172 573.5 0.0 1.3e-172 573.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I TAL_FSA PF00923.19 CDW54436.1 - 1.8e-93 313.1 0.0 2e-93 312.9 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Folliculin_C PF16692.5 CDW54437.1 - 2.9e-51 174.4 0.2 4.5e-51 173.7 0.2 1.2 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.8 CDW54437.1 - 2.5e-46 157.9 0.0 3.9e-46 157.3 0.0 1.3 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport ANTH PF07651.16 CDW54438.1 - 2.7e-51 174.2 0.0 3.7e-47 160.6 0.0 2.0 2 0 0 2 2 2 2 ANTH domain ENTH PF01417.20 CDW54438.1 - 2.2e-15 56.8 0.1 3.2e-15 56.3 0.1 1.3 1 0 0 1 1 1 1 ENTH domain MFS_1 PF07690.16 CDW54439.1 - 6.9e-07 28.5 27.2 8.8e-07 28.2 27.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PTPLA PF04387.14 CDW54439.1 - 0.059 13.1 0.4 0.059 13.1 0.4 2.4 3 1 0 3 3 3 0 Protein tyrosine phosphatase-like protein, PTPLA PSII PF00421.19 CDW54439.1 - 0.16 10.6 0.3 0.24 10.0 0.3 1.2 1 0 0 1 1 1 0 Photosystem II protein Herpes_LMP1 PF05297.11 CDW54439.1 - 0.74 9.0 16.3 0.033 13.4 1.6 2.3 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) RCC1 PF00415.18 CDW54440.1 - 2.8e-57 191.1 15.6 1.5e-11 44.7 0.1 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDW54440.1 - 2.1e-28 97.5 22.4 2.7e-07 30.2 0.2 7.8 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Mcl1_mid PF12341.8 CDW54440.1 - 0.18 11.1 0.6 5.7 6.2 0.0 3.2 2 1 1 4 4 4 0 Minichromosome loss protein, Mcl1, middle region CH PF00307.31 CDW54441.1 - 6.1e-24 84.3 0.1 7.7e-24 84.0 0.1 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 CDW54441.1 - 2.1e-12 46.4 2.8 2.1e-12 46.4 2.8 1.7 2 0 0 2 2 2 1 Calponin family repeat CAMSAP_CH PF11971.8 CDW54441.1 - 0.00019 21.2 0.0 0.00027 20.7 0.0 1.2 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.11 CDW54441.1 - 0.006 16.8 0.1 0.0099 16.1 0.1 1.3 1 0 0 1 1 1 1 CDC24 Calponin DUF2203 PF09969.9 CDW54441.1 - 0.11 13.3 0.0 0.18 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) G-patch PF01585.23 CDW54442.1 - 5.9e-11 42.1 0.6 1e-10 41.3 0.6 1.4 1 0 0 1 1 1 1 G-patch domain Ank_2 PF12796.7 CDW54442.1 - 4.7e-09 36.7 0.2 8.5e-09 35.9 0.2 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW54442.1 - 2.9e-08 34.1 0.3 9.6e-07 29.2 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW54442.1 - 0.0005 20.3 0.5 1.8 9.4 0.0 3.7 3 1 1 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 CDW54442.1 - 0.0005 20.3 0.1 0.0021 18.3 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) zf-C2H2 PF00096.26 CDW54443.1 - 2e-42 141.3 95.6 4.6e-06 26.8 2.1 11.4 11 0 0 11 11 11 11 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW54443.1 - 4e-42 140.8 91.7 2.9e-09 36.9 0.8 12.0 12 0 0 12 12 12 10 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW54443.1 - 3.2e-33 111.5 88.4 0.0001 22.8 1.6 11.3 11 0 0 11 11 11 11 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CDW54443.1 - 5.9e-17 61.1 83.4 4.8e-06 26.2 1.3 10.3 10 1 0 10 10 10 7 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 CDW54443.1 - 4.3e-07 30.1 6.5 2.3e-05 24.5 2.0 10.2 12 0 0 12 12 12 4 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW54443.1 - 2.8e-06 27.5 60.2 0.017 15.5 3.0 9.8 10 0 0 10 10 10 5 Zinc-finger of C2H2 type zf-C2HE PF16278.5 CDW54443.1 - 0.0003 21.2 57.7 0.0021 18.4 5.5 8.5 4 2 5 9 9 9 3 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 CDW54443.1 - 0.012 15.3 5.6 0.034 13.9 0.8 10.3 11 3 0 11 11 10 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 CDW54443.1 - 0.014 15.4 0.6 0.014 15.4 0.6 10.6 11 0 0 11 11 11 0 C2H2-type zinc finger BolA PF01722.18 CDW54443.1 - 0.028 14.7 5.5 0.32 11.3 0.1 3.5 3 0 0 3 3 3 0 BolA-like protein zf-C2H2_2 PF12756.7 CDW54443.1 - 0.032 14.6 60.4 0.036 14.4 8.8 8.4 2 1 5 8 8 7 0 C2H2 type zinc-finger (2 copies) Zn-C2H2_12 PF18112.1 CDW54443.1 - 2.1 8.9 15.0 6.9 7.2 0.2 6.0 6 0 0 6 6 6 0 Autophagy receptor zinc finger-C2H2 domain zinc_ribbon_15 PF17032.5 CDW54443.1 - 3.4 8.5 40.5 0.86 10.4 1.1 5.9 1 1 6 8 8 8 0 zinc-ribbon family Spermine_synth PF01564.17 CDW54444.1 - 1.2e-66 223.8 0.0 1.9e-66 223.1 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 CDW54444.1 - 4.3e-22 77.7 0.0 9.1e-22 76.7 0.0 1.6 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 CDW54444.1 - 0.00013 22.6 0.0 0.00029 21.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 CDW54444.1 - 0.0022 17.6 0.0 0.003 17.1 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.12 CDW54444.1 - 0.0028 18.4 0.0 0.005 17.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW54444.1 - 0.0051 16.6 0.0 0.0072 16.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW54444.1 - 0.028 14.0 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDW54444.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PXA PF02194.15 CDW54445.1 - 1.2e-19 71.1 0.1 2.4e-19 70.0 0.1 1.6 1 0 0 1 1 1 1 PXA domain PX PF00787.24 CDW54445.1 - 6.3e-13 48.7 0.4 1.6e-12 47.4 0.0 1.9 2 0 0 2 2 2 1 PX domain RGS PF00615.19 CDW54445.1 - 2.5e-07 30.9 0.0 1.1e-06 28.9 0.1 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain EST1_DNA_bind PF10373.9 CDW54446.1 - 6.6e-08 32.4 3.8 2.6e-07 30.4 3.8 1.9 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 CDW54446.1 - 2e-05 25.2 0.1 5.9e-05 23.7 0.1 1.9 1 0 0 1 1 1 1 Telomerase activating protein Est1 PIN_4 PF13638.6 CDW54446.1 - 0.01 16.1 0.1 0.025 14.9 0.1 1.6 1 0 0 1 1 1 0 PIN domain BTB_2 PF02214.22 CDW54447.1 - 1.3e-13 51.1 0.1 9.7e-13 48.3 0.1 2.2 1 1 0 1 1 1 1 BTB/POZ domain UDPG_MGDP_dh_N PF03721.14 CDW54448.1 - 1.3e-38 132.5 0.0 5.5e-27 94.6 0.0 2.5 2 1 1 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 CDW54448.1 - 8.7e-36 122.5 0.0 1.2e-34 118.9 0.0 2.6 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 CDW54448.1 - 9.5e-30 102.7 0.0 2.2e-29 101.5 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Sacchrp_dh_NADP PF03435.18 CDW54448.1 - 0.075 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Rep_N PF08724.10 CDW54448.1 - 0.11 12.2 0.0 5.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Rep protein catalytic domain like HABP4_PAI-RBP1 PF04774.15 CDW54449.1 - 3.9e-20 72.8 7.9 3.9e-20 72.8 7.9 2.7 2 1 1 3 3 3 1 Hyaluronan / mRNA binding family IHABP4_N PF16174.5 CDW54449.1 - 0.00053 20.6 16.6 0.00053 20.6 16.6 3.3 1 1 0 2 2 2 1 Intracellular hyaluronan-binding protein 4 N-terminal CH PF00307.31 CDW54450.1 - 1.7e-11 44.3 0.2 4.8e-11 42.8 0.2 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain TMF_TATA_bd PF12325.8 CDW54450.1 - 0.00049 20.3 10.8 0.25 11.6 0.1 2.9 2 0 0 2 2 2 2 TATA element modulatory factor 1 TATA binding ADIP PF11559.8 CDW54450.1 - 0.066 13.3 13.1 0.73 9.9 1.2 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ZapB PF06005.12 CDW54450.1 - 0.21 12.1 5.6 2.3 8.7 1.0 2.8 2 0 0 2 2 2 0 Cell division protein ZapB BST2 PF16716.5 CDW54450.1 - 0.27 11.8 14.8 0.86 10.2 4.5 3.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Allexi_40kDa PF05549.11 CDW54450.1 - 0.36 10.3 15.6 0.12 11.8 0.2 4.0 4 0 0 4 4 4 0 Allexivirus 40kDa protein CEP63 PF17045.5 CDW54450.1 - 0.52 10.2 10.0 0.24 11.3 3.8 2.3 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa EzrA PF06160.12 CDW54450.1 - 1.6 6.8 8.4 1.4 7.0 2.2 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA UPF0242 PF06785.11 CDW54450.1 - 1.8 8.6 7.7 9.5 6.3 0.4 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 CDW54450.1 - 2.8 8.6 5.4 7.4 7.3 0.1 2.9 2 1 0 2 2 2 0 Initiation control protein YabA CENP-F_leu_zip PF10473.9 CDW54450.1 - 3 7.8 12.5 0.7 9.9 3.8 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.6 CDW54450.1 - 4.3 7.0 12.0 1 9.1 2.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) FAM76 PF16046.5 CDW54450.1 - 6.5 6.0 23.3 0.24 10.7 11.5 2.8 1 1 0 2 2 2 0 FAM76 protein TACC_C PF05010.14 CDW54450.1 - 7.7 6.2 11.1 1.5 8.6 4.2 2.3 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Filament PF00038.21 CDW54450.1 - 7.9 6.0 9.7 1.8 8.1 3.6 2.2 2 0 0 2 2 2 0 Intermediate filament protein Aida_N PF08910.10 CDW54450.1 - 9.6 6.7 6.2 19 5.7 2.2 3.0 3 0 0 3 3 3 0 Aida N-terminus wnt PF00110.19 CDW54451.1 - 3.5e-120 401.2 23.2 4.2e-120 401.0 23.2 1.0 1 0 0 1 1 1 1 wnt family TROVE PF05731.11 CDW54452.1 - 5.9e-69 233.2 0.0 7.4e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 TROVE domain Synaptobrevin PF00957.21 CDW54453.1 - 3.6e-34 116.4 5.1 4.1e-34 116.3 5.1 1.0 1 0 0 1 1 1 1 Synaptobrevin DUF3671 PF12420.8 CDW54453.1 - 0.0054 16.8 0.2 0.0075 16.3 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function LMBR1 PF04791.16 CDW54453.1 - 0.0095 14.9 0.3 0.01 14.8 0.3 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Fusion_gly PF00523.18 CDW54453.1 - 0.011 14.0 0.3 0.013 13.8 0.3 1.0 1 0 0 1 1 1 0 Fusion glycoprotein F0 MCU PF04678.13 CDW54453.1 - 0.014 15.5 0.0 0.015 15.4 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Orf78 PF06024.12 CDW54453.1 - 0.069 13.5 0.3 0.088 13.1 0.3 1.2 1 0 0 1 1 1 0 Orf78 (ac78) DUF2207 PF09972.9 CDW54453.1 - 0.076 11.8 0.1 0.076 11.8 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF247 PF03140.15 CDW54453.1 - 0.081 12.1 0.1 0.091 12.0 0.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function CD34_antigen PF06365.12 CDW54453.1 - 0.081 12.5 0.3 0.1 12.2 0.3 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family ODV-E18 PF10717.9 CDW54453.1 - 0.12 12.2 0.4 0.18 11.7 0.4 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ASFV_J13L PF05568.11 CDW54453.1 - 0.38 10.5 2.8 0.35 10.6 1.4 1.7 2 0 0 2 2 2 0 African swine fever virus J13L protein Sigma_reg_N PF13800.6 CDW54453.1 - 0.45 10.8 3.9 0.69 10.2 3.9 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal TMEM154 PF15102.6 CDW54453.1 - 0.7 9.8 3.9 0.69 9.8 3.4 1.3 1 1 0 1 1 1 0 TMEM154 protein family DUF515 PF04415.12 CDW54453.1 - 2.8 6.2 7.0 2.3 6.5 6.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF515) UPF0258 PF06789.12 CDW54453.1 - 3.1 7.9 5.7 0.97 9.6 3.1 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0258) SNARE PF05739.19 CDW54453.1 - 4.8 7.3 14.3 1.1 9.3 10.7 1.8 2 0 0 2 2 2 0 SNARE domain DUF3402 PF11882.8 CDW54454.1 - 4.6e-05 22.7 0.1 5.8e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) CYTH PF01928.21 CDW54454.1 - 0.0073 16.2 0.1 0.015 15.2 0.1 1.6 1 1 0 1 1 1 1 CYTH domain Ank_2 PF12796.7 CDW54455.1 - 1.9e-21 76.5 7.6 3.3e-08 34.0 0.0 5.3 3 1 3 6 6 6 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW54455.1 - 1.8e-18 66.3 1.8 8.7e-06 25.9 0.0 4.6 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 CDW54455.1 - 1.4e-17 63.3 3.0 5.4e-05 23.4 0.1 6.2 6 0 0 6 6 6 4 Ankyrin repeat Patatin PF01734.22 CDW54455.1 - 3.1e-17 63.5 1.7 5e-16 59.5 1.7 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase Ank_4 PF13637.6 CDW54455.1 - 3.1e-14 53.1 3.0 7.9e-06 26.3 0.0 5.7 4 2 4 8 8 8 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW54455.1 - 5.2e-14 51.0 1.8 0.0013 19.0 0.0 7.5 8 0 0 8 8 8 2 Ankyrin repeat Phage_T7_Capsid PF05396.11 CDW54455.1 - 0.16 12.4 0.0 3.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Phage T7 capsid assembly protein PDZ_6 PF17820.1 CDW54457.1 - 2.2e-10 40.2 0.0 8.1e-08 32.0 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CDW54457.1 - 2.4e-09 37.4 0.0 9.2e-07 29.1 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 CDW54458.1 - 7e-09 35.9 0.0 1.1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW54458.1 - 1.9e-06 27.6 0.0 3.1e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW54459.1 - 1.5e-09 38.1 0.0 2.1e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW54459.1 - 0.035 13.9 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 PDZ domain PDZ_2 PF13180.6 CDW54459.1 - 0.049 14.0 0.0 0.068 13.5 0.0 1.3 1 0 0 1 1 1 0 PDZ domain PDZ PF00595.24 CDW54460.1 - 1.7e-17 63.5 0.3 2.6e-17 63.0 0.3 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW54460.1 - 4e-11 42.6 0.1 6e-11 42.0 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW54460.1 - 0.0011 19.2 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW54462.1 - 2.5e-46 155.9 8.0 2e-18 66.5 0.1 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 CDW54462.1 - 5.9e-20 71.4 3.9 2.4e-06 27.8 0.1 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 CDW54462.1 - 6.6e-20 70.7 3.7 4.6e-06 26.4 0.6 3.3 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 CDW54462.1 - 2e-05 24.4 0.4 0.79 9.7 0.0 3.3 3 0 0 3 3 3 3 Tricorn protease PDZ domain PDZ_4 PF17816.1 CDW54462.1 - 0.03 14.7 0.0 36 4.8 0.0 3.2 3 0 0 3 3 3 0 PDZ domain tRNA-synt_1b PF00579.25 CDW54463.1 - 2e-63 214.5 0.0 2.4e-63 214.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA_bind PF01588.20 CDW54463.1 - 4.1e-32 110.2 0.0 7.3e-32 109.3 0.0 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain Filamin PF00630.19 CDW54464.1 - 3e-08 34.4 0.0 6.6e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-RING_5 PF14634.6 CDW54464.1 - 1.4e-07 31.4 4.8 1.4e-07 31.4 4.8 3.0 2 0 0 2 2 2 1 zinc-RING finger domain NHL PF01436.21 CDW54464.1 - 5.1e-07 29.4 7.9 0.026 14.5 0.1 5.4 4 1 0 4 4 4 3 NHL repeat zf-RING_UBOX PF13445.6 CDW54464.1 - 3.7e-06 26.9 2.9 3.7e-06 26.9 2.9 3.4 2 1 1 3 3 2 2 RING-type zinc-finger zf-RING_2 PF13639.6 CDW54464.1 - 4e-05 23.9 5.9 4e-05 23.9 5.9 3.5 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4 PF00097.25 CDW54464.1 - 0.00056 19.7 4.5 0.00056 19.7 4.5 3.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 CDW54464.1 - 0.0017 18.4 11.4 0.033 14.3 1.9 2.6 2 0 0 2 2 2 2 FYVE zinc finger Prok-RING_4 PF14447.6 CDW54464.1 - 0.0024 17.7 5.6 0.0024 17.7 5.6 2.7 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-B_box PF00643.24 CDW54464.1 - 0.0065 16.6 10.4 0.0065 16.6 10.4 3.0 3 0 0 3 3 2 1 B-box zinc finger zf-RING_4 PF14570.6 CDW54464.1 - 0.012 15.4 3.6 0.012 15.4 3.6 2.5 2 0 0 2 2 1 0 RING/Ubox like zinc-binding domain Fib_alpha PF08702.10 CDW54464.1 - 0.018 15.2 2.6 0.049 13.8 2.6 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Ion_trans_2 PF07885.16 CDW54466.1 - 1e-38 131.2 17.5 3.6e-21 74.9 4.1 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 CDW54466.1 - 7.8e-08 31.8 10.6 0.00069 18.9 0.3 2.2 2 0 0 2 2 2 2 Ion transport protein Nitr_red_assoc PF09655.10 CDW54466.1 - 0.0012 19.5 0.5 0.0023 18.6 0.5 1.4 1 0 0 1 1 1 1 Conserved nitrate reductase-associated protein (Nitr_red_assoc) DUF1345 PF07077.11 CDW54466.1 - 0.015 15.0 5.0 0.13 12.0 0.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) DUF3671 PF12420.8 CDW54466.1 - 0.93 9.6 3.6 0.71 10.0 0.1 2.6 3 1 0 3 3 3 0 Protein of unknown function DUF1679 PF07914.11 CDW54467.1 - 1.2e-25 90.2 0.0 6e-15 55.0 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.20 CDW54467.1 - 7.1e-21 74.8 0.0 1.7e-10 40.7 0.0 2.1 2 0 0 2 2 2 2 Ecdysteroid kinase APH PF01636.23 CDW54467.1 - 5.8e-06 26.4 0.1 3.1e-05 24.0 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Methyltransf_32 PF13679.6 CDW54467.1 - 0.032 14.2 0.0 0.048 13.7 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain EcKinase PF02958.20 CDW54468.1 - 5.4e-141 469.1 28.5 3.1e-18 66.1 0.6 9.5 7 2 2 9 9 9 8 Ecdysteroid kinase DUF1679 PF07914.11 CDW54468.1 - 1.1e-138 462.6 28.4 9e-30 103.8 0.2 9.7 3 3 6 10 10 10 9 Protein of unknown function (DUF1679) APH PF01636.23 CDW54468.1 - 3.2e-79 266.3 0.0 5.3e-09 36.4 0.0 8.3 8 0 0 8 8 8 8 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 CDW54468.1 - 5.5e-12 45.5 0.0 0.31 10.2 0.0 7.1 8 0 0 8 8 8 4 Fructosamine kinase Tox-SHH PF15652.6 CDW54468.1 - 9.6e-05 23.3 0.0 6.4 7.8 0.0 4.9 5 0 0 5 5 5 1 HNH/Endo VII superfamily toxin with a SHH signature PLA2_inh PF02988.15 CDW54468.1 - 0.00014 22.4 0.8 49 4.7 0.0 5.6 5 0 0 5 5 5 0 Phospholipase A2 inhibitor SpoVR PF04293.13 CDW54468.1 - 0.00023 20.0 2.3 4.6 5.8 0.0 4.8 5 0 0 5 5 5 2 SpoVR like protein DUF3306 PF11748.8 CDW54468.1 - 0.0029 18.4 0.8 15 6.5 0.1 4.4 4 0 0 4 4 4 1 Protein of unknown function (DUF3306) Vsr PF03852.15 CDW54468.1 - 0.023 14.5 5.2 5.2 7.0 0.0 4.4 4 0 0 4 4 4 0 DNA mismatch endonuclease Vsr Ribonuclease_P PF00825.18 CDW54468.1 - 0.071 13.2 0.4 1.6e+02 2.4 0.0 4.6 4 0 0 4 4 4 0 Ribonuclease P Ribosomal_L23 PF00276.20 CDW54468.1 - 0.21 12.0 6.0 9 6.7 0.0 5.9 7 0 0 7 7 6 0 Ribosomal protein L23 Glyco_hydro_15 PF00723.21 CDW54470.1 - 2e-114 382.9 0.0 6.9e-102 341.5 0.0 3.1 2 1 0 2 2 2 2 Glycosyl hydrolases family 15 CNOT11 PF10155.9 CDW54471.1 - 0.008 16.3 1.3 2.6 8.2 0.3 3.0 2 1 0 2 2 2 2 CCR4-NOT transcription complex subunit 11 DHR10 PF18595.1 CDW54471.1 - 0.16 12.0 1.2 3.5 7.7 0.1 2.3 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain GIT_CC PF16559.5 CDW54471.1 - 1.1 9.2 5.3 0.24 11.3 0.3 2.4 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor PTR2 PF00854.21 CDW54472.1 - 8.9e-199 660.2 38.8 1.4e-90 304.0 9.1 4.2 4 0 0 4 4 4 4 POT family MFS_1 PF07690.16 CDW54472.1 - 9.4e-18 64.2 69.3 4.4e-10 39.0 20.3 4.4 3 1 1 4 4 4 3 Major Facilitator Superfamily DUF3464 PF11947.8 CDW54472.1 - 0.073 12.8 5.7 1.8 8.3 1.0 2.6 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TMEM132D_C PF15706.5 CDW54472.1 - 0.13 12.0 4.1 26 4.7 0.0 3.8 2 1 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Sigma_reg_N PF13800.6 CDW54472.1 - 1.5 9.1 5.0 46 4.4 0.0 4.0 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Met_10 PF02475.16 CDW54473.1 - 1.8e-52 178.0 0.0 3.9e-52 176.9 0.0 1.6 1 1 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 CDW54473.1 - 0.0033 17.0 0.0 0.011 15.4 0.0 1.9 1 1 1 2 2 2 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CDW54473.1 - 0.011 16.4 0.1 0.061 14.0 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 CDW54473.1 - 0.019 14.5 0.0 0.042 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain TRM PF02005.16 CDW54473.1 - 0.031 13.5 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase MethyltransfD12 PF02086.15 CDW54473.1 - 0.041 13.6 0.0 0.084 12.5 0.0 1.5 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase Nucleoporin_N PF08801.11 CDW54474.1 - 2.4e-44 151.8 0.3 3.8e-44 151.2 0.3 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 CDW54474.1 - 2.3e-07 30.0 1.6 2.6e-06 26.5 1.6 2.0 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal TFIIE_beta PF02186.15 CDW54474.1 - 0.19 12.1 0.2 0.65 10.3 0.2 1.9 1 0 0 1 1 1 0 TFIIE beta subunit core domain Fam20C PF06702.12 CDW54476.1 - 6.3e-72 241.9 0.0 1.2e-71 241.0 0.0 1.4 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 CDW54476.1 - 0.0001 21.3 0.0 0.00017 20.6 0.0 1.4 1 0 0 1 1 1 1 FAM198 protein DUF1242 PF06842.12 CDW54477.1 - 7.5e-12 44.8 0.7 7.5e-12 44.8 0.7 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1242) DUF2678 PF10856.8 CDW54477.1 - 0.65 10.0 4.2 6.8 6.7 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) DWNN PF08783.11 CDW54478.1 - 1.6e-25 89.1 0.2 3.6e-25 88.0 0.2 1.6 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 CDW54478.1 - 3.2e-10 39.6 4.5 9.2e-10 38.2 4.5 1.9 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CDW54478.1 - 2.5e-05 24.1 1.4 8.5e-05 22.4 1.4 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 CDW54478.1 - 0.0012 18.7 13.1 0.0012 18.7 13.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 CDW54478.1 - 0.0017 18.5 0.0 0.0052 16.9 0.0 1.9 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 CDW54478.1 - 0.029 14.2 17.1 0.019 14.8 14.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW54478.1 - 0.18 11.7 14.2 0.52 10.2 14.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 CDW54478.1 - 0.71 9.8 8.3 1.6 8.7 8.3 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 CDW54478.1 - 1.6 9.0 15.2 4.3 7.6 15.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING ATG13 PF10033.9 CDW54480.1 - 6e-05 22.9 0.1 0.01 15.6 0.0 3.1 2 1 0 2 2 2 2 Autophagy-related protein 13 CS PF04969.16 CDW54481.1 - 8.5e-13 49.1 0.0 1.1e-12 48.7 0.0 1.2 1 0 0 1 1 1 1 CS domain EGF PF00008.27 CDW54482.1 - 1.4 9.3 9.9 1.3 9.4 0.1 3.4 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 CDW54482.1 - 1.5 9.6 7.6 34 5.3 0.3 3.7 2 1 0 2 2 2 0 Human growth factor-like EGF Zona_pellucida PF00100.23 CDW54483.1 - 3.3e-11 43.5 1.4 4.5e-11 43.0 1.4 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain SRAP PF02586.14 CDW54484.1 - 4.3e-45 153.9 0.0 5.3e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) P66_CC PF16563.5 CDW54486.1 - 3e-12 45.9 3.9 1e-11 44.2 3.9 2.0 1 0 0 1 1 1 1 Coiled-coil and interaction region of P66A and P66B with MBD2 IP_trans PF02121.18 CDW54487.1 - 2.5e-100 335.1 0.4 2.9e-100 334.9 0.4 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein CENP-B_N PF04218.13 CDW54488.1 - 6e-06 25.8 0.2 1.4e-05 24.7 0.2 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain RGM_N PF06535.12 CDW54491.1 - 2.2e-34 119.1 0.3 3e-34 118.6 0.3 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus RGM_C PF06534.13 CDW54492.1 - 1.6e-43 148.2 0.0 2.5e-42 144.3 0.0 2.0 1 1 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus Cupin_8 PF13621.6 CDW54493.1 - 1.7e-23 83.7 0.1 4e-23 82.4 0.1 1.6 1 1 0 1 1 1 1 Cupin-like domain HYLS1_C PF15311.6 CDW54493.1 - 3.1e-10 40.6 0.0 6.9e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Hydrolethalus syndrome protein 1 C-terminus JmjC PF02373.22 CDW54493.1 - 4.6e-09 36.7 0.5 1.1e-08 35.5 0.0 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 CDW54493.1 - 2.1e-08 34.0 0.0 2.2e-07 30.6 0.0 2.2 1 1 0 1 1 1 1 Cupin superfamily protein Myc-LZ PF02344.15 CDW54493.1 - 0.0052 16.8 2.9 0.011 15.8 2.9 1.4 1 0 0 1 1 1 1 Myc leucine zipper domain CIA30 PF08547.12 CDW54494.1 - 7.1e-31 107.4 0.0 1.1e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CUB PF00431.20 CDW54495.1 - 7e-82 271.0 0.6 2.1e-22 79.5 0.0 5.3 5 0 0 5 5 5 5 CUB domain Ldl_recept_a PF00057.18 CDW54495.1 - 2.6e-05 24.3 9.3 2.6e-05 24.3 9.3 2.1 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A ODV-E18 PF10717.9 CDW54496.1 - 0.17 11.8 0.2 0.19 11.6 0.2 1.1 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Phage_Gp23 PF10669.9 CDW54496.1 - 1 9.7 4.7 1 9.7 4.5 1.2 1 1 0 1 1 1 0 Protein gp23 (Bacteriophage A118) FixS PF03597.15 CDW54496.1 - 4.9 7.0 9.0 6.8 6.5 9.0 1.2 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type ABC_membrane PF00664.23 CDW54497.1 - 1.1e-100 336.8 27.9 9.7e-65 218.9 13.8 3.3 3 1 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDW54497.1 - 8e-69 230.5 0.0 5.3e-33 114.4 0.0 3.1 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 CDW54497.1 - 1.1e-15 57.7 3.2 5.8e-05 22.6 0.0 4.3 2 2 2 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDW54497.1 - 7.5e-09 36.0 0.1 0.0076 16.5 0.0 3.3 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CDW54497.1 - 2.3e-08 34.1 0.0 0.0084 16.0 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CDW54497.1 - 7.3e-08 33.0 1.9 0.016 15.6 0.2 3.5 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CDW54497.1 - 3.2e-07 30.0 0.1 0.038 13.7 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 CDW54497.1 - 1.9e-06 28.2 0.0 0.03 14.4 0.1 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_24 PF13479.6 CDW54497.1 - 1e-05 25.3 0.0 0.041 13.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CDW54497.1 - 1.8e-05 24.7 0.1 0.044 13.5 0.0 2.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CDW54497.1 - 2.1e-05 25.1 0.4 0.065 13.7 0.1 2.8 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 CDW54497.1 - 3.8e-05 22.7 0.4 0.13 11.1 0.0 2.6 3 0 0 3 3 2 2 Predicted ATPase of the ABC class AAA PF00004.29 CDW54497.1 - 5.5e-05 23.6 0.5 1.5 9.2 0.0 3.9 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDW54497.1 - 8.1e-05 22.2 0.0 0.46 10.0 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region MMR_HSR1 PF01926.23 CDW54497.1 - 9.6e-05 22.4 0.0 0.14 12.2 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Rad17 PF03215.15 CDW54497.1 - 0.00014 21.9 0.0 0.017 15.0 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 CDW54497.1 - 0.00015 22.3 0.0 0.96 10.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CDW54497.1 - 0.00032 20.7 0.0 1.6 8.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) G-alpha PF00503.20 CDW54497.1 - 0.00033 19.9 0.0 0.66 9.1 0.0 2.4 2 0 0 2 2 2 2 G-protein alpha subunit AAA_21 PF13304.6 CDW54497.1 - 0.00051 19.9 0.6 0.45 10.3 0.0 3.4 3 1 1 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 CDW54497.1 - 0.00056 19.2 0.1 1.3 8.2 0.0 2.6 3 0 0 3 3 2 2 Zeta toxin AAA_30 PF13604.6 CDW54497.1 - 0.0014 18.4 0.1 1.3 8.7 0.0 3.0 2 2 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDW54497.1 - 0.0015 18.9 0.0 3.4 8.1 0.0 2.7 2 0 0 2 2 2 1 RNA helicase ATP-synt_ab PF00006.25 CDW54497.1 - 0.0032 17.2 0.0 0.27 10.8 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Cytidylate_kin PF02224.18 CDW54497.1 - 0.0037 17.0 0.0 9.3 5.9 0.0 3.3 3 0 0 3 3 3 0 Cytidylate kinase PRK PF00485.18 CDW54497.1 - 0.004 16.9 0.0 1.9 8.2 0.0 2.5 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family IstB_IS21 PF01695.17 CDW54497.1 - 0.0044 16.8 0.7 3.9 7.2 0.0 3.6 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_28 PF13521.6 CDW54497.1 - 0.0059 16.9 0.1 1.9 8.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain Septin PF00735.18 CDW54497.1 - 0.0085 15.4 0.0 2.6 7.2 0.0 2.3 2 0 0 2 2 2 1 Septin Roc PF08477.13 CDW54497.1 - 0.011 15.9 1.0 8.6 6.6 0.0 3.6 4 0 0 4 4 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 CDW54497.1 - 0.016 15.4 0.0 8.9 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDW54497.1 - 0.017 14.7 0.0 6.9 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 CDW54497.1 - 0.019 14.4 0.1 4.1 6.8 0.0 3.2 4 0 0 4 4 4 0 Bacterial TniB protein AAA_14 PF13173.6 CDW54497.1 - 0.023 14.7 0.0 1.7 8.7 0.0 2.9 3 0 0 3 3 2 0 AAA domain Dynamin_N PF00350.23 CDW54497.1 - 0.026 14.6 0.1 0.38 10.8 0.1 2.5 2 0 0 2 2 2 0 Dynamin family UPF0542 PF15086.6 CDW54497.1 - 0.029 14.3 1.9 7.2 6.6 0.2 3.1 3 0 0 3 3 2 0 Uncharacterised protein family UPF0542 NB-ARC PF00931.22 CDW54497.1 - 0.031 13.4 0.0 3.1 6.9 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain NACHT PF05729.12 CDW54497.1 - 0.033 14.1 0.0 8.9 6.2 0.0 2.6 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 CDW54497.1 - 0.049 13.5 0.2 5.9 6.8 0.1 2.8 2 1 1 3 3 2 0 NTPase ATP_bind_1 PF03029.17 CDW54497.1 - 0.052 13.3 0.0 8.4 6.1 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Sigma54_activat PF00158.26 CDW54497.1 - 0.063 13.0 0.0 2.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.18 CDW54497.1 - 0.08 12.3 0.1 0.79 9.0 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_10 PF12846.7 CDW54497.1 - 0.081 11.8 0.2 1.7 7.4 0.1 2.4 2 0 0 2 2 2 0 AAA-like domain DUF3987 PF13148.6 CDW54497.1 - 0.14 11.1 0.0 2.8 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) SbcCD_C PF13558.6 CDW54497.1 - 0.21 11.8 8.8 4 7.7 0.2 3.9 3 2 0 3 3 2 0 Putative exonuclease SbcCD, C subunit DUF5006 PF16397.5 CDW54498.1 - 0.15 11.2 0.1 0.22 10.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5006) ThiF PF00899.21 CDW54499.1 - 3.7e-44 150.9 0.2 5.5e-44 150.4 0.2 1.2 1 0 0 1 1 1 1 ThiF family UDPG_MGDP_dh_N PF03721.14 CDW54499.1 - 0.00099 18.7 0.2 0.0016 18.0 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 CDW54499.1 - 0.0083 15.8 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 CDW54499.1 - 0.011 16.0 0.6 0.23 11.7 0.2 2.7 2 1 0 2 2 2 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CDW54499.1 - 0.024 14.9 3.2 0.54 10.5 3.2 2.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CDW54499.1 - 0.024 15.1 0.0 0.065 13.7 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 CDW54499.1 - 0.025 13.9 0.0 0.059 12.7 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PglD_N PF17836.1 CDW54499.1 - 0.055 14.1 0.2 0.13 12.9 0.2 1.7 1 1 0 1 1 1 0 PglD N-terminal domain An_peroxidase PF03098.15 CDW54501.1 - 1.1e-164 548.9 0.0 1.4e-164 548.6 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase ShK PF01549.24 CDW54501.1 - 0.00028 21.3 10.5 0.0014 19.1 10.5 2.4 1 0 0 1 1 1 1 ShK domain-like PHD PF00628.29 CDW54502.1 - 1.9e-08 34.1 11.3 5.2e-08 32.7 11.3 1.8 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CDW54502.1 - 0.017 14.6 5.7 0.041 13.4 5.7 1.7 1 0 0 1 1 1 0 PHD-finger MFS_1 PF07690.16 CDW54503.1 - 6.3e-32 110.9 48.0 7.1e-27 94.3 37.0 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily ubiquitin PF00240.23 CDW54504.1 - 5.8e-27 93.3 0.1 7.2e-27 92.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDW54504.1 - 2.7e-13 49.5 0.1 4e-13 49.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDW54504.1 - 0.0001 22.7 0.1 0.00058 20.3 0.0 2.1 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CDW54504.1 - 0.0028 17.5 0.0 0.004 17.0 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDW54504.1 - 0.084 13.0 0.1 0.25 11.5 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CDW54504.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.7 1 1 1 2 2 2 0 Ubiquitin-like domain Arfaptin PF06456.13 CDW54505.1 - 1.4e-71 240.7 5.8 1.9e-71 240.3 5.8 1.1 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.24 CDW54505.1 - 3.3e-10 40.2 0.1 7e-10 39.1 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW54505.1 - 4e-08 33.0 0.1 8.1e-08 32.0 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW54505.1 - 0.0029 17.9 0.1 0.0096 16.2 0.0 1.9 2 0 0 2 2 2 1 PDZ domain Vps5 PF09325.10 CDW54505.1 - 0.014 15.0 0.2 0.12 11.9 0.2 2.5 1 1 0 1 1 1 0 Vps5 C terminal like DUF4205 PF13898.6 CDW54505.1 - 0.13 11.1 0.3 0.2 10.5 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) adh_short PF00106.25 CDW54506.1 - 3.4e-44 150.6 0.0 4.5e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW54506.1 - 2.4e-21 76.3 0.0 3.3e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW54506.1 - 5.7e-09 36.1 0.3 1.6e-08 34.7 0.3 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CDW54506.1 - 0.033 14.1 0.5 0.065 13.1 0.5 1.5 1 0 0 1 1 1 0 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 CDW54506.1 - 0.066 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.16 CDW54506.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PhoLip_ATPase_C PF16212.5 CDW54507.1 - 1.4e-81 273.9 23.8 1.4e-81 273.9 23.8 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDW54507.1 - 3.5e-25 87.5 8.1 3.5e-25 87.5 8.1 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CDW54507.1 - 3.7e-09 36.5 0.1 8e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDW54507.1 - 1.1e-06 29.1 0.3 0.15 12.3 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CDW54507.1 - 6.2e-06 25.9 0.0 6.2e-06 25.9 0.0 2.7 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDW54507.1 - 0.0019 18.0 0.1 0.0039 17.0 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Prominin PF05478.11 CDW54507.1 - 0.02 12.9 2.3 0.039 11.9 2.3 1.4 1 0 0 1 1 1 0 Prominin SLC12 PF03522.15 CDW54508.1 - 1.7e-124 416.2 0.0 2e-124 415.9 0.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.21 CDW54508.1 - 6.6e-91 305.3 27.2 8e-91 305.0 27.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_N PF08403.10 CDW54508.1 - 0.049 13.1 0.0 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 Amino acid permease N-terminal PAX PF00292.18 CDW54509.1 - 5.6e-71 236.3 0.6 9.7e-71 235.5 0.6 1.4 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 CDW54509.1 - 0.00047 19.9 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_32 PF13565.6 CDW54509.1 - 0.0044 17.6 0.0 1.1 9.9 0.1 2.5 1 1 1 2 2 2 2 Homeodomain-like domain HTH_28 PF13518.6 CDW54509.1 - 0.029 14.5 0.0 0.058 13.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Ribosomal_S13_N PF08069.12 CDW54509.1 - 0.064 13.3 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain PRRSV_Env PF02340.15 CDW54510.1 - 0.032 13.6 0.3 0.057 12.8 0.3 1.3 1 0 0 1 1 1 0 PRRSV putative envelope protein She9_MDM33 PF05546.11 CDW54510.1 - 0.083 12.7 4.4 0.15 11.9 4.4 1.4 1 0 0 1 1 1 0 She9 / Mdm33 family Tsc35 PF15079.6 CDW54510.1 - 0.94 9.0 4.9 0.65 9.5 1.0 2.1 1 1 1 2 2 2 0 Testis-specific protein 35 Fib_alpha PF08702.10 CDW54510.1 - 4.1 7.6 6.8 1.3 9.2 0.5 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Pkinase PF00069.25 CDW54511.1 - 1.9e-60 204.4 0.0 1.3e-59 201.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54511.1 - 3.9e-31 108.3 0.0 2.6e-30 105.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 CDW54511.1 - 6.6e-10 38.6 0.0 1.6e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 CDW54511.1 - 1.6e-08 34.3 0.0 2.8e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDW54511.1 - 0.0083 16.1 0.1 0.023 14.7 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW54511.1 - 0.0093 15.3 0.0 0.032 13.6 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDW54511.1 - 0.011 15.4 0.0 0.025 14.1 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Chitin_synth_2 PF03142.15 CDW54512.1 - 4.9e-30 104.6 6.8 7e-29 100.8 0.0 2.4 1 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CDW54512.1 - 5.3e-13 49.3 1.7 5.3e-13 49.3 1.7 3.1 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CDW54512.1 - 3.9e-08 33.5 0.0 9.8e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDW54512.1 - 0.036 13.9 0.0 0.08 12.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Brix PF04427.18 CDW54513.1 - 2.8e-40 138.5 0.2 3.6e-40 138.2 0.2 1.1 1 0 0 1 1 1 1 Brix domain Arcadin_1 PF18653.1 CDW54513.1 - 0.058 13.5 0.1 0.28 11.3 0.0 2.1 2 0 0 2 2 2 0 Arcadin 1 DsrH PF04077.12 CDW54513.1 - 0.069 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 DsrH like protein Tnp_P_element PF12017.8 CDW54513.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Transposase protein DUF1894 PF08979.11 CDW54513.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1894) TolA_bind_tri PF16331.5 CDW54514.1 - 0.0014 18.7 1.2 0.0014 18.7 1.2 8.9 8 1 0 8 8 8 2 TolA binding protein trimerisation GRIP PF01465.20 CDW54514.1 - 0.046 13.6 0.2 0.24 11.4 0.0 2.4 2 0 0 2 2 2 0 GRIP domain Phage_tail_NK PF16532.5 CDW54514.1 - 0.14 11.8 0.1 0.63 9.7 0.1 2.2 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales Pellino PF04710.14 CDW54515.1 - 7.1e-167 555.2 2.0 5.5e-166 552.3 2.0 1.9 1 1 0 1 1 1 1 Pellino zf-Di19 PF05605.12 CDW54515.1 - 0.013 15.7 5.4 0.78 10.1 1.1 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Prok-RING_4 PF14447.6 CDW54515.1 - 0.063 13.1 10.5 0.64 9.9 0.3 3.6 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CDW54515.1 - 5 7.5 13.8 2 8.8 0.7 3.6 3 1 0 3 3 3 0 Ring finger domain CAP PF00188.26 CDW54516.1 - 7e-06 26.9 0.4 7e-06 26.9 0.4 2.0 2 1 0 2 2 2 1 Cysteine-rich secretory protein family Kunitz_BPTI PF00014.23 CDW54517.1 - 7.3 6.9 15.9 0.75 10.1 3.5 3.3 2 1 0 2 2 2 0 Kunitz/Bovine pancreatic trypsin inhibitor domain Ion_trans_2 PF07885.16 CDW54518.1 - 4.6e-28 97.0 21.7 3e-14 52.7 8.0 3.1 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CDW54518.1 - 2.1e-06 27.1 7.4 0.00021 20.6 0.8 2.3 2 0 0 2 2 2 2 Ion transport protein TMEM43 PF07787.12 CDW54518.1 - 0.47 9.8 7.0 0.043 13.2 1.2 2.2 1 1 0 2 2 2 0 Transmembrane protein 43 OPT PF03169.15 CDW54518.1 - 1.3 7.6 7.3 0.17 10.4 1.3 2.1 2 0 0 2 2 2 0 OPT oligopeptide transporter protein SAYSvFN PF10260.9 CDW54518.1 - 6.7 6.7 8.5 3 7.8 1.6 3.2 3 0 0 3 3 3 0 Uncharacterized conserved domain (SAYSvFN) Mito_carr PF00153.27 CDW54519.1 - 2.4e-55 184.5 2.9 9.5e-18 63.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RabGAP-TBC PF00566.18 CDW54520.1 - 1.1e-30 106.9 0.0 1.6e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Serpin PF00079.20 CDW54521.1 - 6.6e-82 275.8 0.2 7.3e-82 275.6 0.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 CDW54522.1 - 1.1e-112 377.0 6.0 1.3e-112 376.8 6.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) ABC_tran PF00005.27 CDW54523.1 - 1.4e-56 190.8 0.0 3.3e-31 108.6 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 CDW54523.1 - 3.1e-37 128.5 41.8 1.1e-22 80.7 14.1 2.7 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 CDW54523.1 - 2.6e-18 66.9 0.3 1e-07 32.1 0.0 4.6 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDW54523.1 - 3.7e-08 34.1 1.0 0.00033 21.2 0.0 3.1 3 0 0 3 3 3 2 AAA domain SMC_N PF02463.19 CDW54523.1 - 7.5e-05 22.3 0.0 0.65 9.4 0.0 3.7 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDW54523.1 - 0.00088 19.0 0.2 0.12 12.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain SRP54 PF00448.22 CDW54523.1 - 0.0017 18.0 0.2 0.28 10.8 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 CDW54523.1 - 0.002 17.9 0.1 0.51 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDW54523.1 - 0.0047 17.3 0.0 2.4 8.5 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDW54523.1 - 0.018 14.9 0.1 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase MukB PF04310.12 CDW54523.1 - 0.024 14.5 0.5 0.38 10.5 0.0 2.5 2 0 0 2 2 2 0 MukB N-terminal AAA PF00004.29 CDW54523.1 - 0.051 14.0 0.1 17 5.8 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW54523.1 - 0.078 13.2 0.1 17 5.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CDW54523.1 - 0.16 11.6 0.3 3.2 7.3 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 CDW54523.1 - 0.19 11.8 0.8 11 6.0 0.0 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain Helicase_C PF00271.31 CDW54524.1 - 1e-19 70.9 0.1 9.3e-10 38.8 0.0 3.2 3 0 0 3 3 3 3 Helicase conserved C-terminal domain DEAD PF00270.29 CDW54524.1 - 1.1e-14 54.6 0.0 7.4e-14 51.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase HEM4 PF02602.15 CDW54524.1 - 0.032 13.6 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 Uroporphyrinogen-III synthase HemD ResIII PF04851.15 CDW54524.1 - 0.19 11.7 0.0 0.48 10.4 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit RPN6_N PF18055.1 CDW54525.1 - 1e-24 87.1 2.6 1e-24 87.1 2.6 2.6 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 CDW54525.1 - 1.6e-17 63.9 0.7 5.7e-17 62.1 0.4 2.1 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 CDW54525.1 - 0.0024 17.6 0.0 0.0055 16.4 0.0 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_19 PF14559.6 CDW54525.1 - 0.013 16.0 1.7 0.096 13.2 0.4 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DDRGK PF09756.9 CDW54525.1 - 0.044 13.4 0.3 0.044 13.4 0.3 2.5 3 0 0 3 3 3 0 DDRGK domain L27_1 PF09058.10 CDW54525.1 - 0.25 11.4 2.3 45 4.1 0.1 3.8 4 0 0 4 4 4 0 L27_1 TPR_6 PF13174.6 CDW54525.1 - 1.8 9.3 4.3 1e+02 3.8 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPD52 PF04201.15 CDW54525.1 - 2.4 7.7 8.5 4.9 6.7 1.4 2.6 3 0 0 3 3 3 0 Tumour protein D52 family TH1 PF04858.13 CDW54526.1 - 1.2e-126 423.7 0.1 1.4e-126 423.5 0.1 1.0 1 0 0 1 1 1 1 TH1 protein PA28_beta PF02252.18 CDW54527.1 - 1.6e-08 34.3 1.5 3.2e-08 33.3 1.5 1.4 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit IMD PF08397.11 CDW54527.1 - 0.58 9.5 4.8 0.54 9.6 2.7 1.9 2 0 0 2 2 2 0 IRSp53/MIM homology domain EGF_3 PF12947.7 CDW54528.1 - 6.2e-49 163.9 240.7 4.3e-10 39.6 6.1 19.3 18 2 0 18 18 18 15 EGF domain EGF_CA PF07645.15 CDW54528.1 - 7.6e-21 74.0 25.1 1.2e-10 41.4 5.6 18.3 15 3 3 18 18 18 5 Calcium-binding EGF domain cEGF PF12662.7 CDW54528.1 - 1.9e-19 69.2 133.4 9.7e-06 25.4 5.8 15.0 14 0 0 14 14 14 10 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 CDW54528.1 - 1.7e-07 31.1 28.5 3.3e-05 23.8 1.3 16.2 16 0 0 16 16 16 6 MSP1 EGF domain 1 EB PF01683.18 CDW54528.1 - 2.2e-07 31.0 231.9 0.24 11.7 13.1 17.3 7 4 10 17 17 17 10 EB module EGF PF00008.27 CDW54528.1 - 4.6e-06 26.8 18.8 1.2e-05 25.5 4.9 19.0 18 0 0 18 18 18 8 EGF-like domain hEGF PF12661.7 CDW54528.1 - 0.00013 22.4 3.1 0.00013 22.4 3.1 20.6 22 1 0 22 22 22 7 Human growth factor-like EGF FXa_inhibition PF14670.6 CDW54528.1 - 0.0024 18.1 7.5 0.0024 18.1 7.5 17.1 12 3 4 16 16 16 1 Coagulation Factor Xa inhibitory site Metallophos PF00149.28 CDW54529.1 - 1.7e-39 136.5 0.1 2.3e-39 136.0 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW54529.1 - 2.7e-23 82.1 0.3 6.4e-23 80.9 0.3 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain P22_AR_C PF10548.9 CDW54529.1 - 0.0079 16.3 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 P22AR C-terminal domain Y_phosphatase PF00102.27 CDW54530.1 - 2.2e-71 240.1 0.1 2.9e-71 239.8 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase MTABC_N PF16185.5 CDW54530.1 - 1e-45 156.2 5.6 1e-45 156.2 5.6 1.5 2 0 0 2 2 2 1 Mitochondrial ABC-transporter N-terminal five TM region DSPc PF00782.20 CDW54530.1 - 0.011 15.5 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW54530.1 - 0.024 14.8 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 CDW54530.1 - 0.031 14.2 0.1 0.054 13.5 0.1 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Ipi1_N PF12333.8 CDW54531.1 - 2.3e-07 31.3 0.1 2e-06 28.4 0.0 2.7 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation Mito_carr PF00153.27 CDW54532.1 - 2e-13 50.0 0.0 2.6e-10 40.1 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein Mpp10 PF04006.12 CDW54533.1 - 1e-92 311.6 33.7 4.9e-86 289.5 9.9 3.0 2 1 1 3 3 3 3 Mpp10 protein Integrin_alpha2 PF08441.12 CDW54534.1 - 1.9e-78 264.4 0.0 2.5e-78 264.1 0.0 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 CDW54534.1 - 3.2e-18 65.5 29.3 2.2e-10 40.5 0.3 5.8 7 0 0 7 7 7 3 FG-GAP repeat VCBS PF13517.6 CDW54534.1 - 1.7e-10 41.3 6.5 5.3e-08 33.3 0.5 3.3 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PMP1_2 PF08114.11 CDW54534.1 - 0.088 12.6 0.7 0.24 11.2 0.7 1.7 1 0 0 1 1 1 0 ATPase proteolipid family TetR_N PF00440.23 CDW54534.1 - 3.8 7.4 4.2 20 5.1 0.0 3.1 3 0 0 3 3 3 0 Bacterial regulatory proteins, tetR family JIP_LZII PF16471.5 CDW54535.1 - 0.0075 16.4 1.8 0.0075 16.4 1.8 8.0 4 3 5 9 9 9 1 JNK-interacting protein leucine zipper II Tup_N PF08581.10 CDW54535.1 - 0.011 16.1 8.2 0.011 16.1 8.2 6.8 2 2 4 7 7 7 0 Tup N-terminal Pox_A_type_inc PF04508.12 CDW54535.1 - 0.067 13.1 0.0 0.067 13.1 0.0 5.6 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat DUF5082 PF16888.5 CDW54535.1 - 0.16 12.3 45.6 0.09 13.1 6.6 5.2 3 3 1 4 4 4 0 Domain of unknown function (DUF5082) Pet100 PF09803.9 CDW54535.1 - 0.62 10.6 4.2 0.77 10.3 0.1 3.4 3 0 0 3 3 3 0 Pet100 DUF3584 PF12128.8 CDW54535.1 - 0.9 7.0 58.7 1.6 6.2 37.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Lebercilin PF15619.6 CDW54535.1 - 0.9 9.2 62.7 0.05 13.3 9.4 4.7 2 1 2 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease Baculo_PEP_C PF04513.12 CDW54535.1 - 3.5 7.7 20.0 0.15 12.1 0.3 4.5 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus MatP_C PF17414.2 CDW54535.1 - 5.2 7.4 12.5 0.39 10.9 0.2 5.0 4 1 1 6 6 6 0 MatP C-terminal ribbon-helix-helix domain COesterase PF00135.28 CDW54536.1 - 3.7e-109 365.9 0.0 5.6e-109 365.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW54536.1 - 4.7e-07 29.9 0.0 1.1e-06 28.7 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDW54536.1 - 0.025 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDW54536.1 - 0.029 15.0 0.0 0.049 14.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 CDW54536.1 - 0.05 12.5 0.0 0.095 11.6 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme Hum_adeno_E3A PF05393.11 CDW54536.1 - 0.057 13.4 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein Peptidase_S9 PF00326.21 CDW54536.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family HycI PF01750.18 CDW54536.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase maturation protease Ribosomal_L24e PF01246.20 CDW54538.1 - 5.9e-28 96.9 1.8 5.9e-28 96.9 1.8 2.3 2 1 0 2 2 2 1 Ribosomal protein L24e Peptidase_C12 PF01088.21 CDW54538.1 - 0.025 14.3 0.9 0.032 14.0 0.9 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase, family 1 GBP_C PF02841.14 CDW54538.1 - 0.32 10.4 11.4 0.47 9.8 11.4 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Mito_carr PF00153.27 CDW54539.1 - 8.3e-55 182.7 0.3 6.8e-18 64.4 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Ion_trans_2 PF07885.16 CDW54540.1 - 6.1e-31 106.2 13.1 4.8e-16 58.5 1.9 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 CDW54540.1 - 0.063 12.5 8.4 0.98 8.6 0.1 2.5 2 1 1 3 3 3 0 Ion transport protein IRK PF01007.20 CDW54540.1 - 0.072 12.9 4.4 0.084 12.7 0.2 2.6 2 2 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain TF_AP-2 PF03299.14 CDW54541.1 - 4.4e-56 190.0 0.0 5.2e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor AP-2 TF_AP-2 PF03299.14 CDW54542.1 - 2.8e-22 79.7 0.1 3.9e-22 79.2 0.1 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 DUF4371 PF14291.6 CDW54544.1 - 0.031 13.9 0.0 0.048 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) ShK PF01549.24 CDW54545.1 - 8.8e-13 48.6 22.8 1.9e-06 28.3 6.9 2.3 2 0 0 2 2 2 2 ShK domain-like zf-CCCH PF00642.24 CDW54545.1 - 0.0088 15.9 0.5 1.8 8.6 0.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) ShK PF01549.24 CDW54546.1 - 2.7e-17 63.0 46.9 1.7e-07 31.7 12.2 3.4 3 0 0 3 3 3 3 ShK domain-like zf-CCCH PF00642.24 CDW54546.1 - 0.083 12.8 4.6 8.7 6.4 0.1 3.6 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RhoGAP PF00620.27 CDW54547.1 - 6.5e-33 113.7 0.0 1.4e-32 112.6 0.0 1.6 1 1 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 CDW54547.1 - 1.3e-06 28.2 5.3 2.3e-06 27.4 5.3 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CDW54547.1 - 0.017 15.4 1.9 0.036 14.4 1.9 1.5 1 0 0 1 1 1 0 C1 domain PHD PF00628.29 CDW54547.1 - 0.023 14.6 6.7 0.04 13.8 6.7 1.3 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 CDW54547.1 - 0.12 12.3 5.5 0.22 11.5 5.5 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 CDW54547.1 - 0.2 11.3 2.4 0.42 10.3 2.4 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 CDW54547.1 - 2 8.8 5.5 4.5 7.7 5.5 1.6 1 0 0 1 1 1 0 Ring finger domain DNA_primase_S PF01896.19 CDW54548.1 - 1.1e-52 178.6 0.0 6.3e-52 176.2 0.0 2.3 2 0 0 2 2 2 1 DNA primase small subunit RhoGAP PF00620.27 CDW54548.1 - 1e-37 129.3 0.1 1e-36 126.1 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain CBFD_NFYB_HMF PF00808.23 CDW54548.1 - 4.6e-13 49.2 0.1 3.8e-12 46.3 0.1 2.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone C1_1 PF00130.22 CDW54548.1 - 5.4e-06 26.2 3.4 5.4e-06 26.2 3.4 2.6 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CENP-T_C PF15511.6 CDW54548.1 - 0.0011 19.0 0.0 0.71 10.0 0.0 2.7 2 0 0 2 2 2 2 Centromere kinetochore component CENP-T histone fold C1_2 PF03107.16 CDW54548.1 - 0.0021 18.3 2.5 0.0021 18.3 2.5 1.9 2 0 0 2 2 2 1 C1 domain Histone PF00125.24 CDW54548.1 - 0.0023 18.3 0.0 0.0066 16.8 0.0 1.8 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TMF_TATA_bd PF12325.8 CDW54548.1 - 0.024 14.9 5.9 0.065 13.5 5.9 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding PHD PF00628.29 CDW54548.1 - 0.042 13.7 4.4 0.12 12.3 4.4 1.8 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 CDW54548.1 - 0.11 12.5 6.2 0.023 14.6 2.3 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 YlqD PF11068.8 CDW54548.1 - 0.15 12.5 1.7 0.34 11.3 1.7 1.6 1 0 0 1 1 1 0 YlqD protein ABC_tran PF00005.27 CDW54549.1 - 1.1e-24 87.5 0.0 1.8e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW54549.1 - 4.5e-07 30.0 0.6 0.0021 17.9 0.4 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW54549.1 - 0.0014 18.4 0.1 0.0028 17.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDW54549.1 - 0.0048 17.4 0.0 0.0096 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 CDW54549.1 - 0.038 13.7 0.1 0.067 12.9 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.19 CDW54549.1 - 0.048 13.1 0.1 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 CDW54549.1 - 0.082 12.5 0.2 0.17 11.5 0.2 1.6 1 1 0 1 1 1 0 AAA domain DUF3584 PF12128.8 CDW54549.1 - 0.13 9.7 0.0 0.19 9.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ABC_tran PF00005.27 CDW54550.1 - 2.7e-17 63.6 0.0 5.4e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW54550.1 - 1.3e-05 25.2 0.5 0.0012 18.7 0.3 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDW54550.1 - 0.0048 16.7 0.1 0.009 15.8 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDW54550.1 - 0.0066 16.2 0.1 0.025 14.3 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain YwcE PF17368.2 CDW54550.1 - 0.049 14.3 2.4 0.17 12.6 2.4 1.9 1 0 0 1 1 1 0 Spore morphogenesis and germination YwcE ABC2_membrane_3 PF12698.7 CDW54550.1 - 0.067 12.3 0.1 0.067 12.3 0.1 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein AAA_23 PF13476.6 CDW54550.1 - 0.2 12.1 0.1 0.43 11.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain PH PF00169.29 CDW54551.1 - 0.00011 22.7 0.0 0.00024 21.6 0.0 1.6 1 0 0 1 1 1 1 PH domain LUC7 PF03194.15 CDW54552.1 - 3e-52 177.8 3.6 9.8e-52 176.1 3.6 1.7 1 1 0 1 1 1 1 LUC7 N_terminus ZapB PF06005.12 CDW54552.1 - 0.022 15.2 1.9 0.065 13.7 1.9 1.7 1 0 0 1 1 1 0 Cell division protein ZapB Spectrin PF00435.21 CDW54552.1 - 0.027 14.9 0.7 0.048 14.1 0.7 1.5 1 0 0 1 1 1 0 Spectrin repeat DUF2786 PF10979.8 CDW54552.1 - 0.04 13.8 1.7 0.093 12.7 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) NPV_P10 PF05531.12 CDW54552.1 - 0.092 13.2 0.1 0.16 12.5 0.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein ABC_tran_CTD PF16326.5 CDW54552.1 - 1 9.6 7.4 0.33 11.2 4.1 1.9 2 1 0 2 2 2 0 ABC transporter C-terminal domain Adap_comp_sub PF00928.21 CDW54553.1 - 1.3e-19 70.6 0.1 3.7e-19 69.1 0.0 1.7 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDW54553.1 - 4.2e-05 23.5 0.9 6.9e-05 22.8 0.9 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Chorein_N PF12624.7 CDW54554.1 - 2.1e-07 31.1 0.0 7.5e-07 29.3 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Pentapeptide_4 PF13599.6 CDW54554.1 - 0.098 12.8 0.1 22 5.3 0.0 2.8 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) LRR_8 PF13855.6 CDW54555.1 - 1.4e-206 668.6 172.4 4.2e-14 52.1 2.2 28.6 7 5 27 34 34 34 33 Leucine rich repeat LRR_4 PF12799.7 CDW54555.1 - 1.3e-87 286.1 191.5 1e-05 25.8 2.9 30.5 21 6 14 36 36 35 28 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW54555.1 - 2.9e-76 253.6 23.6 2.2e-13 50.3 1.5 12.9 4 4 9 14 14 14 13 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 CDW54555.1 - 6.9e-32 110.3 98.3 8.1e-05 22.2 2.8 14.8 4 4 11 15 15 15 13 Leucine-rich repeat LRR_1 PF00560.33 CDW54555.1 - 3.7e-09 35.9 115.9 0.85 10.4 0.2 34.2 41 3 0 41 41 37 3 Leucine Rich Repeat Nitrate_red_gam PF02665.14 CDW54555.1 - 0.00015 21.4 2.7 0.95 9.0 0.0 3.4 3 0 0 3 3 3 2 Nitrate reductase gamma subunit EphA2_TM PF14575.6 CDW54555.1 - 0.00026 21.8 0.6 7.1 7.6 0.0 3.6 3 0 0 3 3 3 1 Ephrin type-A receptor 2 transmembrane domain Amnionless PF14828.6 CDW54555.1 - 0.00031 19.7 0.1 0.6 8.9 0.0 3.2 3 0 0 3 3 3 2 Amnionless DUF5305 PF17231.2 CDW54555.1 - 0.0018 17.7 0.2 0.7 9.3 0.0 3.2 3 0 0 3 3 3 1 Family of unknown function (DUF5305) FAM176 PF14851.6 CDW54555.1 - 0.0084 15.8 0.7 3.4 7.3 0.0 3.5 3 0 0 3 3 3 1 FAM176 family DUF4064 PF13273.6 CDW54555.1 - 0.21 11.9 0.7 1.2 9.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) SKG6 PF08693.10 CDW54555.1 - 1.1 8.7 5.7 1.3 8.4 0.7 2.5 2 0 0 2 2 2 0 Transmembrane alpha-helix domain KLRAQ PF10205.9 CDW54556.1 - 0.092 13.0 1.8 0.46 10.7 0.6 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein EGF PF00008.27 CDW54557.1 - 1.1e-06 28.9 48.3 0.00013 22.2 10.7 5.8 5 1 0 5 5 5 3 EGF-like domain EGF_2 PF07974.13 CDW54557.1 - 9.7e-06 25.9 64.6 0.0049 17.2 9.8 5.8 5 0 0 5 5 5 4 EGF-like domain hEGF PF12661.7 CDW54557.1 - 0.021 15.5 0.3 0.021 15.5 0.3 5.8 4 1 0 4 4 4 0 Human growth factor-like EGF Laminin_EGF PF00053.24 CDW54557.1 - 5.1 7.3 47.9 5.5 7.2 6.3 5.6 1 1 2 4 4 4 0 Laminin EGF domain EGF_alliinase PF04863.13 CDW54557.1 - 7.1 7.1 40.5 0.059 13.8 6.0 5.6 4 1 1 5 5 5 0 Alliinase EGF-like domain Arrestin_N PF00339.29 CDW54558.1 - 7.1e-25 87.8 0.0 1.1e-24 87.2 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CDW54558.1 - 1.8e-18 67.3 0.0 5.6e-16 59.2 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain DM PF00751.18 CDW54559.1 - 6.5e-22 77.2 13.5 1.1e-21 76.5 13.5 1.4 1 0 0 1 1 1 1 DM DNA binding domain DMA PF03474.14 CDW54559.1 - 1.4e-10 40.6 0.0 2.4e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 DMRTA motif CUE PF02845.16 CDW54559.1 - 0.0036 17.0 0.0 0.0068 16.1 0.0 1.4 1 0 0 1 1 1 1 CUE domain CBS PF00571.28 CDW54561.1 - 7.9e-18 64.7 9.2 7.7e-07 29.5 0.8 4.5 4 0 0 4 4 4 4 CBS domain Sortase PF04203.13 CDW54561.1 - 0.12 12.2 0.0 12 5.7 0.0 2.4 2 0 0 2 2 2 0 Sortase domain TRAPP PF04051.16 CDW54561.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.5 1 1 0 1 1 1 0 Transport protein particle (TRAPP) component AAA_5 PF07728.14 CDW54563.1 - 1.8e-94 313.1 0.0 3.5e-33 114.5 0.0 3.5 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW54563.1 - 4e-08 33.8 0.5 0.068 13.5 0.0 4.9 4 1 0 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 CDW54563.1 - 7.7e-08 32.7 0.0 0.022 15.0 0.0 3.4 2 1 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CDW54563.1 - 3.1e-07 30.0 0.1 0.0053 16.2 0.0 3.7 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI TniB PF05621.11 CDW54563.1 - 0.00015 21.2 0.0 0.095 12.1 0.0 2.7 2 0 0 2 2 2 1 Bacterial TniB protein AAA_14 PF13173.6 CDW54563.1 - 0.00046 20.2 0.1 0.01 15.9 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 CDW54563.1 - 0.00058 20.3 0.0 1.4 9.3 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDW54563.1 - 0.0012 18.4 0.0 1.7 8.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region RsgA_GTPase PF03193.16 CDW54563.1 - 0.0022 17.9 0.0 0.6 10.0 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 CDW54563.1 - 0.0025 18.3 0.0 0.21 12.1 0.0 2.9 2 0 0 2 2 2 1 ABC transporter Roc PF08477.13 CDW54563.1 - 0.0036 17.5 0.0 3.9 7.7 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CDW54563.1 - 0.0074 16.0 0.0 0.77 9.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 CDW54563.1 - 0.012 15.5 0.1 1.2 9.0 0.0 3.4 4 0 0 4 4 4 0 NACHT domain Zeta_toxin PF06414.12 CDW54563.1 - 0.017 14.4 0.0 9.3 5.5 0.0 3.7 4 0 0 4 4 4 0 Zeta toxin Viral_helicase1 PF01443.18 CDW54563.1 - 0.028 14.2 0.0 0.38 10.5 0.0 2.5 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 CDW54563.1 - 0.028 15.0 0.0 0.35 11.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CDW54563.1 - 0.032 13.4 0.0 0.83 8.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 CDW54563.1 - 0.033 14.3 0.0 2.9 8.1 0.0 2.9 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 CDW54563.1 - 0.052 13.6 0.0 3.9 7.5 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 CDW54563.1 - 0.088 12.7 0.0 0.52 10.2 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_3 PF07726.11 CDW54563.1 - 0.089 12.6 0.0 25 4.7 0.0 3.9 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 CDW54563.1 - 0.11 12.9 0.0 0.36 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 CDW54563.1 - 0.11 12.1 0.0 6.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Ras family RNA_helicase PF00910.22 CDW54563.1 - 0.13 12.7 0.0 2.3 8.7 0.0 2.4 2 0 0 2 2 2 0 RNA helicase DUF745 PF05335.13 CDW54563.1 - 0.14 11.9 0.2 1 9.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF745) ODC_AZ PF02100.17 CDW54563.1 - 0.15 12.0 0.2 0.35 10.9 0.2 1.5 1 0 0 1 1 1 0 Ornithine decarboxylase antizyme Sigma54_activat PF00158.26 CDW54563.1 - 0.18 11.5 0.0 11 5.6 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain TUDOR PF00567.24 CDW54564.1 - 5e-12 45.9 0.0 1.1e-11 44.8 0.0 1.6 2 0 0 2 2 2 1 Tudor domain Pyridoxal_deC PF00282.19 CDW54565.1 - 1.5e-85 287.1 0.0 2.2e-85 286.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CDW54565.1 - 3.6e-10 39.6 0.0 4.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 CDW54565.1 - 0.00065 18.5 0.0 0.0015 17.3 0.0 1.5 2 0 0 2 2 2 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Spt20 PF12090.8 CDW54566.1 - 0.0097 15.5 14.3 0.011 15.3 14.3 1.3 1 0 0 1 1 1 1 Spt20 family UPF0560 PF10577.9 CDW54566.1 - 0.072 11.6 8.5 0.084 11.4 8.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4570 PF15134.6 CDW54566.1 - 0.076 13.0 9.3 0.12 12.3 9.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) PAT1 PF09770.9 CDW54566.1 - 0.13 10.6 16.4 0.14 10.4 16.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TraV PF09676.10 CDW54566.1 - 0.13 13.3 7.0 0.22 12.5 7.0 1.3 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) TFIIA PF03153.13 CDW54566.1 - 0.2 11.6 19.4 0.23 11.4 19.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SprA-related PF12118.8 CDW54566.1 - 0.24 10.5 11.5 0.33 10.0 11.5 1.2 1 0 0 1 1 1 0 SprA-related family TERB2 PF15101.6 CDW54566.1 - 1.4 9.0 9.1 2.1 8.3 9.1 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 KH_1 PF00013.29 CDW54567.1 - 5.4e-154 500.2 27.9 3.2e-13 49.3 0.3 15.9 15 1 0 15 15 15 15 KH domain SLS PF14611.6 CDW54567.1 - 1.9e-11 44.2 10.1 0.21 11.4 0.0 7.3 3 3 4 7 7 7 5 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 CDW54567.1 - 4.5e-10 39.2 23.2 1.3 8.9 0.2 10.7 10 1 1 11 11 11 4 KH domain KH_5 PF13184.6 CDW54567.1 - 0.0025 17.9 21.5 1.2 9.2 0.1 9.1 8 1 1 9 9 9 1 NusA-like KH domain KAsynt_C_assoc PF16197.5 CDW54567.1 - 0.005 17.3 0.0 23 5.5 0.0 4.0 4 0 0 4 4 4 0 Ketoacyl-synthetase C-terminal extension DUF4974 PF16344.5 CDW54567.1 - 0.0053 16.7 0.2 13 5.9 0.0 4.3 4 0 0 4 4 4 1 Domain of unknown function (DUF4974) Ndr PF03096.14 CDW54567.1 - 0.043 12.5 0.5 0.16 10.6 0.0 2.2 3 0 0 3 3 3 0 Ndr family TrkA_C PF02080.21 CDW54567.1 - 0.22 11.4 4.4 66 3.4 0.1 6.0 8 0 0 8 8 8 0 TrkA-C domain YqgF PF14639.6 CDW54567.1 - 0.39 10.5 17.1 7.4 6.3 0.4 5.7 6 0 0 6 6 6 0 Holliday-junction resolvase-like of SPT6 CX PF01705.19 CDW54568.1 - 2.9e-08 34.1 3.5 4.7e-08 33.5 3.5 1.4 1 0 0 1 1 1 1 CX module EVC2_like PF12297.8 CDW54568.1 - 0.17 10.5 0.0 0.22 10.2 0.0 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Collectrin PF16959.5 CDW54568.1 - 0.18 11.6 0.5 0.27 11.0 0.5 1.2 1 0 0 1 1 1 0 Renal amino acid transporter Shisa PF13908.6 CDW54568.1 - 0.88 9.8 10.0 3.7 7.7 10.0 1.9 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator MMgT PF10270.9 CDW54569.1 - 3.9e-11 43.2 0.1 4.4e-11 43.0 0.1 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter PROL5-SMR PF15621.6 CDW54569.1 - 0.088 13.3 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family RSB_motif PF16294.5 CDW54570.1 - 6.8e-11 42.3 3.6 6.8e-11 42.3 3.6 3.4 5 0 0 5 5 5 1 RNSP1-SAP18 binding (RSB) motif SAP PF02037.27 CDW54570.1 - 2.5e-09 36.7 1.9 5.6e-09 35.5 1.9 1.6 1 0 0 1 1 1 1 SAP domain RRM_1 PF00076.22 CDW54570.1 - 0.044 13.6 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Comm PF15957.5 CDW54570.1 - 0.67 10.3 0.0 0.67 10.3 0.0 2.2 2 0 0 2 2 2 0 Commissureless MMgT PF10270.9 CDW54572.1 - 3.9e-11 43.2 0.1 4.4e-11 43.0 0.1 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter PROL5-SMR PF15621.6 CDW54572.1 - 0.087 13.4 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Proline-rich submaxillary gland androgen-regulated family Toxin_3 PF00537.18 CDW54573.1 - 0.067 13.4 19.8 0.054 13.7 6.1 2.5 1 1 1 2 2 2 0 Scorpion toxin-like domain Gamma-thionin PF00304.20 CDW54573.1 - 0.073 13.4 23.3 0.26 11.6 6.0 2.9 2 1 0 2 2 2 0 Gamma-thionin family SPRY PF00622.28 CDW54574.1 - 2.7e-18 66.2 0.3 4.3e-18 65.6 0.3 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 CDW54574.1 - 0.0028 17.5 2.3 0.009 15.9 2.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Drf_GBD PF06371.13 CDW54574.1 - 0.012 15.2 0.2 0.029 13.9 0.1 1.6 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain Prok-RING_4 PF14447.6 CDW54574.1 - 0.092 12.6 3.3 0.23 11.4 3.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 HCNGP PF07818.13 CDW54575.1 - 2e-29 102.1 0.2 4.8e-29 100.9 0.2 1.6 1 0 0 1 1 1 1 HCNGP-like protein Ion_trans_2 PF07885.16 CDW54576.1 - 5.4e-35 119.2 14.5 4.1e-18 65.1 0.2 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CDW54576.1 - 1.4e-11 44.1 4.7 6.8e-07 28.8 0.4 2.4 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 CDW54576.1 - 0.043 13.6 4.7 1.5 8.6 0.1 2.9 3 0 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain Telomere_reg-2 PF10193.9 CDW54577.1 - 2.3e-25 89.2 1.5 6e-25 87.8 0.3 2.4 2 0 0 2 2 2 1 Telomere length regulation protein Laminin_G_1 PF00054.23 CDW54578.1 - 0.042 14.1 0.0 0.064 13.5 0.0 1.2 1 0 0 1 1 1 0 Laminin G domain Adeno_E3_CR2 PF02439.15 CDW54578.1 - 0.059 13.1 0.7 0.09 12.6 0.7 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DAG1 PF05454.11 CDW54578.1 - 0.23 10.8 0.9 0.48 9.8 0.0 1.9 3 0 0 3 3 3 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Elf1 PF05129.13 CDW54579.1 - 7.4e-29 99.6 3.2 8.3e-29 99.5 3.2 1.0 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like OrfB_Zn_ribbon PF07282.11 CDW54579.1 - 0.031 14.2 4.1 0.1 12.5 4.1 1.8 1 1 0 1 1 1 0 Putative transposase DNA-binding domain SIR2 PF02146.17 CDW54579.1 - 0.099 12.6 0.4 0.11 12.5 0.4 1.1 1 0 0 1 1 1 0 Sir2 family Zn_Tnp_IS1595 PF12760.7 CDW54579.1 - 0.099 12.6 3.1 0.19 11.8 3.1 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Fer4_4 PF12800.7 CDW54579.1 - 3.7 8.3 7.3 9.1 7.1 0.4 3.1 3 1 0 3 3 3 0 4Fe-4S binding domain G-patch PF01585.23 CDW54580.1 - 1.9e-12 46.8 1.5 3.7e-12 45.9 1.5 1.5 1 0 0 1 1 1 1 G-patch domain FHA PF00498.26 CDW54580.1 - 3.4e-11 43.3 0.0 8.2e-11 42.1 0.0 1.7 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 CDW54580.1 - 2.2e-07 31.1 0.0 5.6e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain OCRE PF17780.1 CDW54580.1 - 0.00028 20.8 3.8 0.00028 20.8 3.8 2.4 2 0 0 2 2 2 1 OCRE domain G-patch_2 PF12656.7 CDW54580.1 - 0.0025 17.9 0.2 0.0044 17.1 0.2 1.4 1 0 0 1 1 1 1 G-patch domain FHA_2 PF17913.1 CDW54580.1 - 0.0078 16.4 0.0 0.017 15.4 0.0 1.5 1 0 0 1 1 1 1 FHA domain DBP10CT PF08147.12 CDW54580.1 - 0.13 12.6 0.4 0.28 11.5 0.4 1.6 1 0 0 1 1 1 0 DBP10CT (NUC160) domain zf-C4 PF00105.18 CDW54581.1 - 1e-30 106.0 14.8 2.8e-30 104.6 14.8 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW54581.1 - 2e-26 92.9 0.3 2.8e-26 92.4 0.3 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor SOBP PF15279.6 CDW54581.1 - 0.38 11.3 2.9 0.7 10.4 2.9 1.4 1 1 0 1 1 1 0 Sine oculis-binding protein polyprenyl_synt PF00348.17 CDW54583.1 - 4.4e-52 176.7 0.3 1.6e-51 174.8 0.3 1.8 1 1 0 1 1 1 1 Polyprenyl synthetase RRM_1 PF00076.22 CDW54583.1 - 1.6e-36 123.9 0.2 3.2e-18 65.3 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW54583.1 - 1.2e-06 28.2 0.1 0.06 12.9 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW54583.1 - 0.0016 18.3 0.0 0.65 9.9 0.0 2.6 2 0 0 2 2 2 2 Occluded RNA-recognition motif NRDE-2 PF08424.10 CDW54583.1 - 0.0023 17.1 8.5 0.0029 16.8 0.2 3.5 3 1 0 3 3 3 1 NRDE-2, necessary for RNA interference Nup35_RRM_2 PF14605.6 CDW54583.1 - 0.0083 16.1 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif TPR_14 PF13428.6 CDW54583.1 - 0.021 15.6 4.4 2.6e+02 2.9 0.0 6.5 6 1 0 6 6 6 0 Tetratricopeptide repeat AFT PF08731.11 CDW54583.1 - 0.055 13.9 0.9 6.9 7.1 0.9 2.7 2 0 0 2 2 2 0 Transcription factor AFT Pkinase PF00069.25 CDW54584.1 - 1.5e-32 113.0 0.0 1.6e-32 112.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54584.1 - 2.5e-12 46.6 0.0 3.1e-12 46.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW54584.1 - 5.1e-05 22.7 0.0 7e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW54584.1 - 0.0098 15.8 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDW54584.1 - 0.097 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 CDW54586.1 - 5.1e-44 150.6 0.0 1e-22 80.8 0.0 2.9 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54586.1 - 5.3e-20 71.8 0.1 1.8e-12 47.1 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase APH PF01636.23 CDW54586.1 - 0.0017 18.3 0.0 2.3 8.1 0.0 3.9 3 1 1 4 4 4 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW54586.1 - 0.013 14.4 2.7 0.27 10.0 0.3 3.2 2 2 0 2 2 2 0 Fungal protein kinase Fructosamin_kin PF03881.14 CDW54586.1 - 0.031 13.5 0.1 5.6 6.1 0.0 2.4 2 0 0 2 2 2 0 Fructosamine kinase zf-C2H2 PF00096.26 CDW54587.1 - 1.1e-15 57.1 18.4 3.8e-05 23.9 0.5 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW54587.1 - 4.5e-11 42.6 16.2 0.0024 18.6 0.3 3.7 4 0 0 4 4 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW54587.1 - 4.1e-10 39.6 14.3 2.9e-05 24.3 0.2 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW54587.1 - 4e-08 33.3 1.7 0.15 12.3 0.0 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW54587.1 - 6.3e-06 26.4 4.2 0.13 12.7 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-Di19 PF05605.12 CDW54587.1 - 8.7e-05 22.7 4.7 0.002 18.4 2.5 2.3 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 CDW54587.1 - 0.00014 21.8 10.5 0.51 10.4 2.6 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CDW54587.1 - 0.0022 18.3 6.9 0.84 10.0 0.0 3.1 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) C1_1 PF00130.22 CDW54587.1 - 0.011 15.5 4.2 0.25 11.3 0.4 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) GAGA PF09237.11 CDW54587.1 - 0.016 15.0 5.4 0.041 13.7 0.8 2.4 1 1 1 2 2 2 0 GAGA factor zf_Hakai PF18408.1 CDW54587.1 - 0.019 14.6 1.5 0.055 13.2 1.5 1.8 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain zf-ribbon_3 PF13248.6 CDW54587.1 - 0.031 13.7 0.5 4.1 7.0 0.0 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_9 PF16293.5 CDW54587.1 - 0.092 12.6 1.9 2 8.3 0.3 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) PyrI_C PF02748.15 CDW54587.1 - 0.14 12.1 1.2 7.7 6.5 0.0 3.0 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 CDW54587.1 - 0.27 11.3 12.0 0.19 11.8 1.2 3.1 3 0 0 3 3 3 0 BED zinc finger Zn-ribbon_8 PF09723.10 CDW54587.1 - 1.2 9.3 4.8 0.37 10.9 0.2 2.4 3 1 0 3 3 2 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 CDW54587.1 - 2.1 8.2 12.4 1.6 8.5 1.4 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2HE PF16278.5 CDW54587.1 - 2.6 8.6 5.6 14 6.2 0.0 3.0 4 0 0 4 4 3 0 C2HE / C2H2 / C2HC zinc-binding finger Prok-RING_1 PF14446.6 CDW54587.1 - 4.7 7.2 7.0 4.9 7.2 0.7 3.2 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 zf-H2C2_5 PF13909.6 CDW54587.1 - 6.6 6.6 17.9 0.21 11.4 0.6 3.8 4 0 0 4 4 4 0 C2H2-type zinc-finger domain PALP PF00291.25 CDW54588.1 - 4.7e-59 200.2 0.1 8.8e-57 192.7 0.1 2.3 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Angiomotin_C PF12240.8 CDW54589.1 - 0.00019 21.1 6.1 0.042 13.4 1.2 2.2 1 1 1 2 2 2 2 Angiomotin C terminal TMF_DNA_bd PF12329.8 CDW54589.1 - 0.016 15.2 3.5 0.31 11.0 0.1 2.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Exonuc_VII_L PF02601.15 CDW54589.1 - 0.49 9.9 3.3 0.55 9.8 3.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PspB PF06667.12 CDW54589.1 - 0.83 9.8 5.6 2.6 8.2 0.6 2.4 1 1 1 2 2 2 0 Phage shock protein B FUSC PF04632.12 CDW54589.1 - 4.2 5.8 4.6 4.9 5.6 4.6 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family KH_1 PF00013.29 CDW54590.1 - 7.2e-08 32.1 0.0 1.5e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 KH domain Tom22 PF04281.13 CDW54592.1 - 0.044 13.6 0.1 0.064 13.0 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 FbpA PF05833.11 CDW54592.1 - 0.071 11.8 0.0 0.073 11.8 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) RNB PF00773.19 CDW54593.1 - 3.7e-99 332.1 0.0 6.1e-99 331.4 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 CDW54593.1 - 1.1e-19 70.3 0.0 2.8e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 CDW54593.1 - 4.7e-09 36.6 1.1 1.4e-08 35.1 0.1 2.3 2 0 0 2 2 2 1 PIN domain Rrp44_CSD1 PF17216.3 CDW54593.1 - 1.2e-08 34.8 0.0 2.3e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 CDW54593.1 - 2.2e-07 31.0 0.0 2.4e-06 27.6 0.0 2.5 2 0 0 2 2 2 1 Cold shock domain Rrp44_S1 PF17215.3 CDW54593.1 - 4e-06 26.7 0.0 8.3e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 S1 domain BRCT PF00533.26 CDW54594.1 - 5.5e-35 119.6 0.4 6.5e-11 42.5 0.0 4.4 4 0 0 4 4 4 3 BRCA1 C Terminus (BRCT) domain zf-ANAPC11 PF12861.7 CDW54594.1 - 9.5e-30 102.5 11.7 2.9e-29 101.0 11.7 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PTCB-BRCT PF12738.7 CDW54594.1 - 1.6e-22 79.2 2.3 1.5e-11 44.1 0.0 3.5 3 0 0 3 3 3 3 twin BRCT domain zf-rbx1 PF12678.7 CDW54594.1 - 1e-18 67.4 16.0 1.5e-18 66.8 14.2 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain BRCT_2 PF16589.5 CDW54594.1 - 1.6e-18 66.9 0.1 1.5e-06 28.5 0.0 4.4 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 CDW54594.1 - 6.8e-12 45.1 0.0 3.5e-08 33.2 0.0 3.5 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 CDW54594.1 - 6e-06 26.3 0.5 0.41 10.7 0.0 3.9 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CDW54594.1 - 1.1e-05 25.6 0.1 0.0029 17.9 0.1 2.5 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain zf-RING_2 PF13639.6 CDW54594.1 - 2.5e-05 24.5 17.4 2.5e-05 24.5 17.4 3.3 2 2 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW54594.1 - 0.66 9.9 22.6 14 5.6 17.0 3.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW54594.1 - 0.88 9.5 20.2 0.68 9.9 13.9 3.0 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PTCB-BRCT PF12738.7 CDW54595.1 - 6.9e-15 54.8 0.2 2.4e-09 37.0 0.7 2.8 2 1 0 2 2 2 2 twin BRCT domain BRCT PF00533.26 CDW54595.1 - 5.9e-12 45.8 0.0 9.6e-05 22.7 0.0 2.5 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CDW54595.1 - 3.7e-10 40.1 0.0 0.0013 19.1 0.0 3.0 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 CDW54595.1 - 1.3e-06 28.4 0.1 0.0082 16.2 0.0 3.0 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Ribosomal_S27e PF01667.17 CDW54596.1 - 5.3e-25 86.9 5.7 6.5e-25 86.6 5.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 E7 PF00527.18 CDW54596.1 - 0.031 14.5 0.3 0.043 14.0 0.3 1.3 1 1 0 1 1 1 0 E7 protein, Early protein DSPc PF00782.20 CDW54597.1 - 2e-22 79.4 0.0 2.5e-22 79.1 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW54597.1 - 2.6e-06 27.6 0.0 3.7e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate DUF442 PF04273.13 CDW54597.1 - 0.00023 21.2 0.0 0.00046 20.2 0.0 1.5 1 1 0 1 1 1 1 Putative phosphatase (DUF442) Y_phosphatase PF00102.27 CDW54597.1 - 0.00042 20.0 0.0 0.00051 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 CDW54597.1 - 0.02 14.5 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 CDW54597.1 - 0.03 14.6 0.0 0.049 13.9 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 CDW54597.1 - 0.17 11.8 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family MSC PF09402.10 CDW54598.1 - 5.7e-13 49.0 0.0 9.3e-13 48.3 0.0 1.3 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain LEM PF03020.15 CDW54598.1 - 3.1e-08 33.1 0.0 7.4e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 LEM domain DUF2207 PF09972.9 CDW54598.1 - 0.0081 15.0 0.6 0.013 14.3 0.6 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3169 PF11368.8 CDW54598.1 - 0.032 13.7 1.0 0.054 13.0 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3169) HPD PF05044.12 CDW54598.1 - 0.049 13.5 0.5 0.15 11.9 0.4 1.8 3 0 0 3 3 3 0 Homeo-prospero domain Adeno_E3_CR2 PF02439.15 CDW54599.1 - 0.028 14.2 0.3 0.047 13.4 0.3 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Amnionless PF14828.6 CDW54599.1 - 0.07 11.9 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 Amnionless Protocadherin PF08374.11 CDW54599.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Protocadherin FAM176 PF14851.6 CDW54599.1 - 0.16 11.6 0.0 0.16 11.6 0.0 1.7 2 0 0 2 2 2 0 FAM176 family zf-A20 PF01754.16 CDW54601.1 - 1.1e-11 44.4 6.6 1.1e-11 44.4 6.6 2.4 3 0 0 3 3 3 1 A20-like zinc finger zf-AN1 PF01428.16 CDW54601.1 - 6.4e-09 35.8 6.3 6.4e-09 35.8 6.3 2.0 2 0 0 2 2 2 1 AN1-like Zinc finger Arfaptin PF06456.13 CDW54602.1 - 3.3e-43 147.9 1.2 5.3e-43 147.2 1.2 1.2 1 0 0 1 1 1 1 Arfaptin-like domain FAD-SLDH PF12318.8 CDW54602.1 - 0.0059 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Membrane bound FAD containing D-sorbitol dehydrogenase Peptidase_S24 PF00717.23 CDW54602.1 - 0.19 11.7 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Peptidase S24-like Nup35_RRM PF05172.13 CDW54604.1 - 3e-12 46.4 0.1 1.9e-11 43.8 0.1 2.0 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 CDW54604.1 - 0.00013 21.9 0.0 0.0002 21.3 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif TrmE_N PF10396.9 CDW54605.1 - 3.3e-28 98.3 0.0 3.8e-28 98.1 0.0 1.0 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus GCV_T PF01571.21 CDW54605.1 - 0.0014 18.1 0.0 0.0016 17.8 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Foamy_BEL PF03274.14 CDW54605.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.4 1 1 1 2 2 2 0 Foamy virus BEL 1/2 protein Sema PF01403.19 CDW54607.1 - 4.6e-94 315.6 0.0 1e-93 314.5 0.0 1.6 2 0 0 2 2 2 1 Sema domain PSI PF01437.25 CDW54607.1 - 8e-05 23.1 8.0 8e-05 23.1 8.0 2.4 2 0 0 2 2 2 1 Plexin repeat DSPc PF00782.20 CDW54608.1 - 1.3e-32 112.4 0.0 2.2e-32 111.7 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW54608.1 - 0.005 16.4 0.0 0.0083 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PGK PF00162.19 CDW54611.1 - 3.4e-153 510.1 1.2 3.8e-153 509.9 1.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase SNARE_assoc PF09335.11 CDW54612.1 - 6e-08 33.2 0.0 6e-08 33.2 0.0 2.4 3 1 0 3 3 3 1 SNARE associated Golgi protein PCNP PF15473.6 CDW54613.1 - 1.7e-32 113.3 5.8 2e-32 113.1 5.8 1.1 1 0 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family PRKCSH PF07915.13 CDW54614.1 - 2.4e-12 47.7 3.4 6.6e-12 46.3 3.4 1.7 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 CDW54614.1 - 0.00039 20.1 0.0 0.00061 19.5 0.0 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein CIMR PF00878.18 CDW54614.1 - 0.054 13.6 0.4 0.11 12.5 0.4 1.5 1 0 0 1 1 1 0 Cation-independent mannose-6-phosphate receptor repeat Ank_2 PF12796.7 CDW54617.1 - 6.1e-35 119.7 2.9 7.9e-14 52.0 0.5 4.8 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW54617.1 - 2.8e-28 97.9 2.7 6.4e-06 26.6 0.0 6.2 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW54617.1 - 7.8e-23 78.1 6.3 0.011 16.1 0.1 9.9 9 0 0 9 9 9 4 Ankyrin repeat Ank_5 PF13857.6 CDW54617.1 - 4.3e-18 65.1 11.8 3.1e-05 24.2 0.5 8.6 5 3 5 10 10 10 5 Ankyrin repeats (many copies) Ank PF00023.30 CDW54617.1 - 7.7e-13 48.3 16.9 0.00043 20.6 0.5 9.1 7 2 2 9 9 8 4 Ankyrin repeat TPR_2 PF07719.17 CDW54617.1 - 1.1e-05 25.2 0.9 0.00097 19.1 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDW54617.1 - 6.4e-05 23.0 1.9 0.00057 20.0 0.5 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat AAA_16 PF13191.6 CDW54617.1 - 0.0011 19.3 0.1 0.0067 16.8 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain TPR_1 PF00515.28 CDW54617.1 - 0.0037 17.0 0.2 0.039 13.8 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat NACHT PF05729.12 CDW54617.1 - 0.015 15.2 0.1 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 CDW54617.1 - 0.021 15.1 0.0 0.063 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain TPR_14 PF13428.6 CDW54617.1 - 0.022 15.5 0.4 0.27 12.2 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_28 PF13521.6 CDW54617.1 - 0.033 14.4 0.0 0.083 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW54617.1 - 0.043 14.4 0.0 0.35 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain TPR_16 PF13432.6 CDW54617.1 - 0.048 14.3 0.2 0.12 13.0 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat YdjC PF04794.12 CDW54617.1 - 0.049 13.6 0.0 0.28 11.1 0.0 2.0 2 0 0 2 2 2 0 YdjC-like protein TniB PF05621.11 CDW54617.1 - 0.063 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein RRM_1 PF00076.22 CDW54618.1 - 4.3e-14 52.1 0.0 8.5e-14 51.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BolA PF01722.18 CDW54618.1 - 4.5e-13 49.3 0.0 1.7e-12 47.4 0.0 1.9 2 0 0 2 2 2 1 BolA-like protein PC4 PF02229.16 CDW54618.1 - 0.016 14.9 0.0 0.18 11.5 0.0 2.5 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) Pkinase PF00069.25 CDW54619.1 - 2e-63 214.3 1.3 4.2e-63 213.2 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54619.1 - 8.5e-41 139.9 2.7 1.2e-40 139.4 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CDW54619.1 - 0.098 12.6 0.0 0.098 12.6 0.0 3.1 3 1 0 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 CDW54620.1 - 3.2e-72 243.1 0.0 3.8e-72 242.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54620.1 - 1.5e-43 149.0 0.0 1.8e-43 148.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW54620.1 - 4.2e-09 36.1 0.0 8e-09 35.2 0.0 1.5 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW54620.1 - 3.3e-05 23.0 0.3 4.2e-05 22.7 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 CDW54620.1 - 0.0061 15.7 0.0 0.009 15.1 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 FTA2 PF13095.6 CDW54620.1 - 0.0079 15.8 0.2 0.071 12.7 0.0 2.2 1 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDW54620.1 - 0.013 14.8 0.2 0.02 14.2 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW54620.1 - 0.013 15.4 0.2 0.033 14.1 0.2 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW54620.1 - 0.035 12.9 0.0 0.056 12.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 CDW54620.1 - 0.079 12.5 0.2 0.16 11.6 0.1 1.6 2 0 0 2 2 2 0 RIO1 family Glycos_transf_2 PF00535.26 CDW54621.1 - 9e-35 120.0 0.0 1.4e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDW54621.1 - 2.9e-14 53.4 0.7 6.2e-14 52.3 0.7 1.6 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_2 PF10111.9 CDW54621.1 - 3.8e-07 29.9 0.0 9.6e-07 28.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 CDW54621.1 - 4.8e-07 29.9 0.0 8.7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDW54621.1 - 1.9e-06 27.4 0.1 4.6e-06 26.2 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase MIP-T3 PF10243.9 CDW54622.1 - 6.4e-35 119.6 1.4 1.1e-34 118.8 0.2 2.1 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 CH-like domain MIP-T3_C PF17749.1 CDW54622.1 - 3.5e-10 40.1 7.4 3.5e-10 40.1 7.4 2.9 3 1 0 3 3 3 1 Microtubule-binding protein MIP-T3 C-terminal region PI_PP_I PF18363.1 CDW54622.1 - 0.0028 17.8 1.1 0.0064 16.6 1.1 1.6 1 0 0 1 1 1 1 Phosphoinositide phosphatase insertion domain TBCA PF02970.16 CDW54622.1 - 0.02 15.2 6.3 0.02 15.2 6.3 3.8 4 1 0 4 4 4 0 Tubulin binding cofactor A Sec20 PF03908.13 CDW54622.1 - 0.041 13.8 3.6 0.12 12.3 0.9 2.7 1 1 1 2 2 2 0 Sec20 Macoilin PF09726.9 CDW54622.1 - 0.048 12.2 21.7 0.09 11.3 21.7 1.3 1 1 0 1 1 1 0 Macoilin family ETC_C1_NDUFA5 PF04716.14 CDW54622.1 - 0.06 13.2 1.1 0.26 11.1 0.4 2.5 2 0 0 2 2 2 0 ETC complex I subunit conserved region BLOC1_2 PF10046.9 CDW54622.1 - 0.13 12.6 4.8 0.42 10.9 4.8 2.0 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2935 PF11155.8 CDW54622.1 - 1.6 9.1 5.3 4.8 7.5 0.4 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) Forkhead PF00250.18 CDW54623.1 - 1.2e-37 128.0 0.0 2e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain PROCN PF08083.11 CDW54624.1 - 7.1e-234 775.9 7.9 7.1e-234 775.9 7.9 1.8 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 CDW54624.1 - 4.3e-127 422.4 0.7 7.3e-127 421.7 0.7 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 CDW54624.1 - 8.8e-90 298.7 2.8 2.1e-89 297.5 2.8 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 CDW54624.1 - 7e-87 289.0 4.9 1.9e-86 287.6 4.9 1.8 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 CDW54624.1 - 6.6e-73 243.1 0.1 1.6e-72 241.8 0.0 1.8 2 0 0 2 2 2 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 CDW54624.1 - 2.7e-52 175.9 0.1 7.4e-52 174.5 0.1 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 CDW54624.1 - 8.9e-48 160.6 0.5 2.6e-47 159.1 0.5 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 CDW54624.1 - 1.9e-08 34.3 0.0 5e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CR6_interact PF10147.9 CDW54624.1 - 0.059 13.1 0.1 0.23 11.1 0.1 2.0 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Pkinase PF00069.25 CDW54626.1 - 6.2e-69 232.3 0.1 7.6e-69 232.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54626.1 - 5.8e-36 124.1 0.0 8.9e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW54626.1 - 0.0011 19.0 0.0 0.002 18.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDW54626.1 - 0.0018 17.3 0.2 0.003 16.6 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 CDW54626.1 - 0.017 14.7 0.0 0.13 11.8 0.0 2.1 2 1 0 2 2 2 0 Choline/ethanolamine kinase Kdo PF06293.14 CDW54626.1 - 0.021 14.2 0.2 0.037 13.4 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW54626.1 - 0.11 11.3 0.7 0.76 8.5 0.1 1.8 1 1 1 2 2 2 0 Fungal protein kinase Asp_protease_2 PF13650.6 CDW54627.1 - 1.2e-11 45.1 0.0 2.2e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW54627.1 - 1.9e-10 41.1 0.0 3.8e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CDW54627.1 - 8.4e-05 22.4 0.0 0.0048 16.7 0.0 2.2 2 0 0 2 2 2 1 Aspartyl protease zf-CCHC PF00098.23 CDW54627.1 - 0.0036 17.3 2.7 0.0036 17.3 2.7 4.1 4 0 0 4 4 4 1 Zinc knuckle DUF1758 PF05585.12 CDW54627.1 - 0.01 15.6 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 0 Putative peptidase (DUF1758) zf-CCHC_2 PF13696.6 CDW54627.1 - 0.14 12.0 1.5 0.45 10.4 1.5 1.9 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 CDW54627.1 - 0.21 11.3 7.4 0.53 10.1 1.0 2.9 2 0 0 2 2 2 0 Zinc knuckle BTG PF07742.12 CDW54628.1 - 1.5e-34 118.3 0.0 2.8e-34 117.4 0.0 1.5 1 0 0 1 1 1 1 BTG family GDP_Man_Dehyd PF16363.5 CDW54629.1 - 1.2e-152 508.1 0.1 3.5e-143 477.0 0.0 2.0 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDW54629.1 - 6.1e-70 235.4 0.1 2.7e-64 216.9 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDW54629.1 - 0.00012 21.3 0.0 0.0002 20.6 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CDW54629.1 - 0.065 12.3 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NmrA PF05368.13 CDW54629.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.6 1 1 0 1 1 1 0 NmrA-like family V-ATPase_C PF03223.15 CDW54631.1 - 4.2e-141 470.6 6.8 4.2e-140 467.4 6.8 1.9 1 1 0 1 1 1 1 V-ATPase subunit C Plant_NMP1 PF06694.11 CDW54631.1 - 0.015 14.4 0.3 0.035 13.2 0.3 1.5 1 1 0 1 1 1 0 Plant nuclear matrix protein 1 (NMP1) MMTV_SAg PF01054.17 CDW54632.1 - 0.06 12.9 0.5 0.12 11.9 0.5 1.5 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen DUF5320 PF17253.2 CDW54632.1 - 0.14 13.2 0.4 42 5.3 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5320) ubiquitin PF00240.23 CDW54633.1 - 1.8e-12 46.8 0.4 2.5e-12 46.4 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDW54633.1 - 2.3e-05 24.1 0.4 3.3e-05 23.6 0.1 1.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 CDW54633.1 - 0.0033 17.3 0.0 0.0055 16.6 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain WD40 PF00400.32 CDW54634.1 - 2.2e-27 94.7 4.4 1.5e-06 28.8 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW54634.1 - 2.7e-13 50.0 0.0 0.0033 17.7 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW54634.1 - 0.0058 16.0 0.0 0.66 9.2 0.0 3.2 2 1 1 4 4 4 1 WD40-like domain Kelch_6 PF13964.6 CDW54634.1 - 0.03 14.6 0.2 0.65 10.4 0.1 3.0 4 0 0 4 4 4 0 Kelch motif PQQ_3 PF13570.6 CDW54634.1 - 0.26 11.8 3.7 20 5.8 0.0 4.3 4 1 1 5 5 5 0 PQQ-like domain FOXP-CC PF16159.5 CDW54635.1 - 1.1e-26 93.3 5.1 1.1e-26 93.3 5.1 3.9 3 1 0 4 4 4 1 FOXP coiled-coil domain Forkhead PF00250.18 CDW54635.1 - 2.5e-25 88.5 0.2 8.4e-25 86.9 0.2 1.9 1 0 0 1 1 1 1 Forkhead domain Seryl_tRNA_N PF02403.22 CDW54635.1 - 3.2 8.0 9.3 0.31 11.3 2.7 2.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Caps_synth_GfcC PF06251.11 CDW54635.1 - 4.7 6.7 12.7 13 5.4 12.7 1.7 1 0 0 1 1 1 0 Capsule biosynthesis GfcC tRNA_Me_trans PF03054.16 CDW54636.1 - 9e-106 353.6 0.0 4.9e-104 347.9 0.0 2.0 1 1 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 CDW54636.1 - 7.6e-07 28.9 0.0 5.1e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.17 CDW54636.1 - 2.2e-06 27.0 0.0 0.00039 19.6 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Asn_synthase PF00733.21 CDW54636.1 - 0.00048 19.9 0.0 0.00071 19.3 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 CDW54636.1 - 0.039 13.5 0.0 0.094 12.2 0.0 1.7 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC DUF2369 PF10179.9 CDW54637.1 - 3.3e-07 30.6 0.1 0.00018 21.8 0.0 3.2 4 0 0 4 4 4 2 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 CDW54637.1 - 0.0022 18.3 0.0 1.5 9.2 0.0 2.9 2 0 0 2 2 2 2 Fibronectin type III domain Ank_4 PF13637.6 CDW54638.1 - 1.6e-25 89.1 1.9 1.9e-09 37.8 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW54638.1 - 3.1e-22 78.9 1.9 4.4e-15 56.0 0.4 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW54638.1 - 1.7e-21 76.0 1.8 7.9e-10 38.8 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CDW54638.1 - 4.9e-20 71.0 5.6 2.2e-07 31.0 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 CDW54638.1 - 9.7e-19 65.5 0.6 6.9e-05 23.0 0.0 5.0 5 0 0 5 5 5 5 Ankyrin repeat Ank_2 PF12796.7 CDW54639.1 - 2.4e-46 156.2 2.9 1.8e-17 63.7 1.2 4.0 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 CDW54639.1 - 1.2e-40 136.1 13.6 8.2e-07 29.2 0.1 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank_3 PF13606.6 CDW54639.1 - 2.8e-40 131.7 7.4 3.1e-05 24.0 0.0 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank_4 PF13637.6 CDW54639.1 - 1e-39 134.4 6.0 2.7e-11 43.7 0.3 6.3 2 1 3 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW54639.1 - 5e-37 125.5 10.7 1.9e-12 47.1 0.3 6.7 1 1 6 7 7 7 7 Ankyrin repeats (many copies) GATase_7 PF13537.6 CDW54639.1 - 0.12 12.3 0.0 31 4.5 0.0 3.5 3 1 1 4 4 4 0 Glutamine amidotransferase domain WD40 PF00400.32 CDW54640.1 - 2.2e-18 66.3 20.3 0.00076 20.2 2.0 6.6 5 1 1 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW54640.1 - 6e-05 23.3 2.9 1.9 8.9 0.0 4.5 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Arf PF00025.21 CDW54641.1 - 5.5e-76 253.9 0.0 6.1e-76 253.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW54641.1 - 6.3e-15 55.5 0.1 8.2e-15 55.1 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDW54641.1 - 1.3e-14 54.2 0.0 1.4e-14 54.0 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CDW54641.1 - 1.8e-12 47.1 0.6 1.5e-09 37.5 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 CDW54641.1 - 1e-11 44.6 0.0 1.3e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDW54641.1 - 1e-11 44.6 0.0 1.3e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDW54641.1 - 0.00024 21.1 0.0 0.00036 20.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SpoOE-like PF09388.10 CDW54641.1 - 0.02 14.8 0.3 0.034 14.0 0.3 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein 6PF2K PF01591.18 CDW54641.1 - 0.086 12.1 0.1 0.16 11.2 0.1 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SNF2_N PF00176.23 CDW54643.1 - 4.3e-41 140.8 0.1 6.6e-41 140.2 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW54643.1 - 2.3e-15 56.9 0.0 8.5e-15 55.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW54643.1 - 1.1e-07 32.1 0.0 6.4e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CDW54643.1 - 0.00032 20.0 0.0 0.0022 17.3 0.0 2.1 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 CDW54643.1 - 0.012 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 CDW54643.1 - 0.013 15.7 0.1 0.045 14.0 0.1 2.0 1 0 0 1 1 1 0 AAA domain Peptidase_M17 PF00883.21 CDW54644.1 - 6e-61 206.4 0.0 7.8e-61 206.0 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain PEP_mutase PF13714.6 CDW54644.1 - 0.027 13.9 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase Astacin PF01400.24 CDW54645.1 - 3e-68 229.2 0.1 3.7e-68 228.9 0.1 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 CDW54645.1 - 1.1e-07 32.2 3.6 2.7e-07 31.0 3.6 1.7 1 0 0 1 1 1 1 ShK domain-like Peptidase_M11 PF05548.11 CDW54645.1 - 0.13 11.4 0.1 0.19 10.8 0.1 1.2 1 0 0 1 1 1 0 Gametolysin peptidase M11 Cadherin PF00028.17 CDW54646.1 - 2.5e-92 303.5 7.6 1.6e-14 54.1 0.1 9.3 9 0 0 9 9 9 9 Cadherin domain Cadherin_2 PF08266.12 CDW54646.1 - 1.5e-05 24.7 0.0 0.081 12.8 0.0 5.0 7 0 0 7 7 7 1 Cadherin-like CATSPERB PF15149.6 CDW54646.1 - 0.012 14.1 0.2 0.035 12.6 0.0 1.7 3 0 0 3 3 3 0 Cation channel sperm-associated protein subunit beta protein family Insulin_TMD PF17870.1 CDW54646.1 - 0.059 13.4 0.1 0.2 11.8 0.1 1.9 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment PepSY PF03413.19 CDW54646.1 - 0.099 13.2 0.0 52 4.5 0.0 3.6 3 0 0 3 3 3 0 Peptidase propeptide and YPEB domain Astacin PF01400.24 CDW54647.1 - 2.8e-43 147.8 0.5 1.7e-37 128.9 0.1 2.1 1 1 1 2 2 2 2 Astacin (Peptidase family M12A) Inositol_P PF00459.25 CDW54648.1 - 7.1e-48 163.5 0.1 1.4e-47 162.5 0.1 1.4 1 1 0 1 1 1 1 Inositol monophosphatase family VHS PF00790.19 CDW54649.1 - 4.6e-44 149.7 5.9 1.1e-43 148.4 0.5 2.9 3 0 0 3 3 3 1 VHS domain Hrs_helical PF12210.8 CDW54649.1 - 2.3e-30 105.0 4.8 2.3e-30 105.0 4.8 2.5 2 0 0 2 2 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate FYVE PF01363.21 CDW54649.1 - 8.5e-15 54.6 3.2 2.2e-14 53.3 3.2 1.7 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 CDW54649.1 - 0.0066 16.6 2.7 0.0066 16.6 2.7 3.4 4 0 0 4 4 4 1 FYVE-type zinc finger ExbD PF02472.16 CDW54649.1 - 0.067 13.4 1.0 0.2 11.8 1.0 1.7 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR zf-RING_5 PF14634.6 CDW54649.1 - 0.23 11.5 9.8 0.52 10.3 9.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Pkinase PF00069.25 CDW54650.1 - 4.7e-68 229.4 0.0 4.3e-67 226.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain cNMP_binding PF00027.29 CDW54650.1 - 5.1e-41 138.7 0.2 4.6e-20 71.5 0.2 3.8 4 0 0 4 4 4 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 CDW54650.1 - 5.9e-31 107.7 0.0 1.1e-30 106.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW54650.1 - 0.0044 17.0 0.2 0.024 14.5 0.1 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family MRP-S34 PF16053.5 CDW54651.1 - 8.4e-23 80.4 0.9 9.6e-23 80.3 0.9 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 EGF PF00008.27 CDW54652.1 - 2.1e-44 149.4 157.2 7.3e-08 32.6 9.4 10.7 10 0 0 10 10 10 10 EGF-like domain EGF_CA PF07645.15 CDW54652.1 - 5.4e-27 93.7 172.0 1.9e-08 34.4 12.0 10.8 4 2 6 10 10 10 9 Calcium-binding EGF domain hEGF PF12661.7 CDW54652.1 - 1.2e-21 76.5 124.9 0.00055 20.5 6.2 11.7 10 1 0 10 10 10 9 Human growth factor-like EGF EGF_2 PF07974.13 CDW54652.1 - 2.6e-18 66.1 184.6 0.0015 18.9 13.0 10.9 11 0 0 11 11 11 8 EGF-like domain FXa_inhibition PF14670.6 CDW54652.1 - 1.8e-10 40.9 139.5 0.012 15.9 8.4 10.7 4 2 5 10 10 10 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW54652.1 - 4.2e-10 39.6 163.9 0.00036 20.6 12.5 11.6 9 2 1 10 10 10 8 EGF domain FLYWCH PF04500.16 CDW54653.1 - 1.4e-11 44.3 3.2 2.6e-11 43.5 3.2 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain MULE PF10551.9 CDW54653.1 - 4e-11 43.2 0.0 8.7e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain DDE_Tnp_ISL3 PF01610.17 CDW54653.1 - 0.0091 15.7 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 1 Transposase PAN_1 PF00024.26 CDW54654.1 - 3.6e-15 55.7 21.5 4.4e-09 36.2 0.7 3.9 4 0 0 4 4 4 3 PAN domain DSPc PF00782.20 CDW54655.1 - 4.6e-28 97.7 0.1 5.6e-28 97.4 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW54655.1 - 0.0007 19.2 0.0 0.00092 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Melibiase_2 PF16499.5 CDW54656.1 - 2.7e-132 440.2 3.1 3.3e-132 439.9 3.1 1.1 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 CDW54656.1 - 0.00019 21.5 0.0 0.00075 19.5 0.0 2.1 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2_C PF17450.2 CDW54656.1 - 0.00066 19.9 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase PF02065.18 CDW54656.1 - 0.0033 16.4 0.0 0.0053 15.8 0.0 1.2 1 0 0 1 1 1 1 Melibiase PKcGMP_CC PF16808.5 CDW54657.1 - 0.0016 18.2 0.5 0.0041 16.9 0.1 1.9 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase HMMR_N PF15905.5 CDW54657.1 - 0.019 14.5 3.8 0.034 13.6 3.8 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal TMF_DNA_bd PF12329.8 CDW54657.1 - 0.03 14.3 3.2 0.4 10.7 0.4 2.6 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF641 PF04859.12 CDW54657.1 - 0.12 12.7 3.1 0.73 10.2 0.1 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 CDW54657.1 - 0.13 12.4 3.9 0.25 11.4 3.9 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4200 PF13863.6 CDW54657.1 - 0.17 12.3 4.5 0.28 11.6 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Macoilin PF09726.9 CDW54657.1 - 0.18 10.3 8.5 0.26 9.8 8.5 1.1 1 0 0 1 1 1 0 Macoilin family DMPK_coil PF08826.10 CDW54657.1 - 0.2 11.8 3.9 3.6 7.8 1.8 2.5 2 0 0 2 2 2 0 DMPK coiled coil domain like TMF_TATA_bd PF12325.8 CDW54657.1 - 0.29 11.4 6.8 7.3 6.8 0.2 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding SKA2 PF16740.5 CDW54657.1 - 0.5 10.2 3.2 0.95 9.3 0.5 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 OmpH PF03938.14 CDW54657.1 - 2.4 8.5 6.0 9.7 6.5 6.1 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FAM76 PF16046.5 CDW54657.1 - 4.9 6.4 7.6 8.8 5.6 7.6 1.5 1 1 0 1 1 1 0 FAM76 protein Carboxyl_trans PF01039.22 CDW54658.1 - 1.7e-193 643.8 0.0 2e-193 643.5 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CDW54658.1 - 0.0067 15.9 0.0 0.025 14.1 0.0 1.9 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) tRNA-synt_1g PF09334.11 CDW54659.1 - 4.2e-83 279.3 0.2 7.3e-82 275.2 0.2 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) Methyltransf_11 PF08241.12 CDW54659.1 - 7e-12 45.8 0.0 3.2e-11 43.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain tRNA-synt_1 PF00133.22 CDW54659.1 - 2.7e-11 42.4 1.1 6.2e-08 31.3 0.0 2.7 3 1 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) Methyltransf_25 PF13649.6 CDW54659.1 - 2e-10 41.2 0.0 1.4e-09 38.5 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain tRNA-synt_1e PF01406.19 CDW54659.1 - 5.9e-07 29.1 0.0 0.0013 18.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Methyltransf_31 PF13847.6 CDW54659.1 - 2.7e-06 27.2 0.0 7e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Anticodon_1 PF08264.13 CDW54659.1 - 2.9e-05 24.1 0.0 6.7e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Methyltransf_23 PF13489.6 CDW54659.1 - 0.0011 18.8 0.0 0.0026 17.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDW54659.1 - 0.027 14.2 0.1 0.47 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 CDW54659.1 - 0.036 13.4 0.0 0.14 11.4 0.0 1.9 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family AveC_like PF17198.4 CDW54659.1 - 0.13 11.6 0.1 0.44 9.9 0.1 1.7 2 0 0 2 2 2 0 Spirocyclase AveC-like OATP PF03137.20 CDW54661.1 - 4.7e-245 814.0 19.9 1.3e-131 439.6 14.4 2.5 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 CDW54661.1 - 9.3e-24 84.0 65.3 1.7e-10 40.4 11.2 5.5 6 0 0 6 6 6 4 Major Facilitator Superfamily Kazal_2 PF07648.15 CDW54661.1 - 2.8e-08 33.7 22.6 0.00033 20.7 7.4 2.8 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Gal-bind_lectin PF00337.22 CDW54661.1 - 1.8e-05 24.3 0.4 0.0017 17.9 0.0 2.4 1 1 1 2 2 2 2 Galactoside-binding lectin TUDOR PF00567.24 CDW54662.1 - 8.5e-11 41.9 0.3 4.1e-10 39.7 0.0 2.2 1 1 1 2 2 2 1 Tudor domain Rho_RNA_bind PF07497.12 CDW54662.1 - 0.11 12.4 0.1 1.5 8.7 0.0 2.6 3 0 0 3 3 3 0 Rho termination factor, RNA-binding domain S1 PF00575.23 CDW54662.1 - 0.13 12.6 1.0 2.1 8.8 0.4 2.2 2 0 0 2 2 2 0 S1 RNA binding domain OATP PF03137.20 CDW54663.1 - 5.4e-11 41.5 0.6 5.9e-11 41.4 0.6 1.0 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family OATP PF03137.20 CDW54664.1 - 8.8e-20 70.5 0.4 1.1e-19 70.2 0.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family FN3_7 PF18447.1 CDW54664.1 - 0.064 13.6 0.3 0.12 12.7 0.3 1.4 1 0 0 1 1 1 0 Fibronectin type III domain RMF PF04957.12 CDW54664.1 - 0.2 11.9 0.0 0.4 10.9 0.0 1.5 1 0 0 1 1 1 0 Ribosome modulation factor OATP PF03137.20 CDW54665.1 - 2e-19 69.3 4.1 4.8e-19 68.0 4.1 1.7 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family JCAD PF15351.6 CDW54666.1 - 0.38 8.5 0.0 0.46 8.2 0.0 1.0 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease C2 PF00168.30 CDW54667.1 - 3.7e-32 110.7 0.0 3e-16 59.6 0.0 2.5 2 0 0 2 2 2 2 C2 domain PDZ PF00595.24 CDW54667.1 - 4.2e-09 36.6 0.0 8.7e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW54667.1 - 9.7e-08 31.7 0.0 2.1e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 PDZ domain FYVE_2 PF02318.16 CDW54667.1 - 4e-06 27.0 18.7 5.2e-05 23.4 9.1 3.0 2 1 0 2 2 2 2 FYVE-type zinc finger Archease PF01951.16 CDW54668.1 - 3.4e-44 150.4 0.4 4.1e-44 150.2 0.4 1.1 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) Laminin_N PF00055.17 CDW54669.1 - 2.7e-83 279.1 0.0 2.7e-83 279.1 0.0 3.3 4 0 0 4 4 4 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 CDW54669.1 - 3.8e-68 225.4 207.5 6.6e-10 39.0 10.9 11.5 11 1 1 12 12 12 10 Laminin EGF domain Laminin_B PF00052.18 CDW54669.1 - 1.7e-22 79.7 0.1 9.2e-22 77.4 0.0 2.3 2 0 0 2 2 2 1 Laminin B (Domain IV) IFRD PF05004.13 CDW54671.1 - 2.3e-47 161.6 0.7 1.1e-23 83.9 0.6 2.1 2 0 0 2 2 2 2 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 CDW54671.1 - 2.7e-09 37.5 1.2 2.7e-09 37.5 1.2 2.5 2 0 0 2 2 2 1 Interferon-related protein conserved region Macro PF01661.21 CDW54672.1 - 5.7e-37 126.4 0.1 8.3e-37 125.8 0.1 1.3 1 0 0 1 1 1 1 Macro domain SH3_9 PF14604.6 CDW54673.1 - 3.7e-06 26.7 0.1 0.0012 18.7 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 CDW54673.1 - 4.5e-06 26.2 0.1 0.00018 21.2 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain Nop10p PF04135.12 CDW54674.1 - 4.2e-18 65.1 1.0 5e-18 64.9 1.0 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Acetyltransf_1 PF00583.25 CDW54675.1 - 5.9e-11 42.6 0.0 7.1e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW54675.1 - 8.8e-09 35.4 0.0 1.2e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW54675.1 - 2.9e-07 30.8 0.1 4.5e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain BRCT_2 PF16589.5 CDW54675.1 - 0.01 16.2 0.0 0.017 15.5 0.0 1.3 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Ribosom_S12_S23 PF00164.25 CDW54676.1 - 1.7e-25 88.8 0.4 3.3e-25 87.9 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S12/S23 CDP-OH_P_transf PF01066.21 CDW54676.1 - 1.1e-07 32.5 1.3 1.1e-07 32.5 1.3 1.9 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase LRR_4 PF12799.7 CDW54677.1 - 4.9e-12 45.9 3.0 0.091 13.2 0.0 6.9 5 3 2 8 8 8 3 Leucine Rich repeats (2 copies) F-box PF00646.33 CDW54677.1 - 2.9e-08 33.4 1.7 1.1e-07 31.5 0.3 2.8 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CDW54677.1 - 1.9e-07 30.8 0.9 1.3e-06 28.1 0.9 2.6 3 0 0 3 3 3 1 F-box-like LRR_8 PF13855.6 CDW54677.1 - 4.1e-07 29.7 8.3 0.25 11.1 1.0 6.7 7 2 1 8 8 8 2 Leucine rich repeat F-box_4 PF15966.5 CDW54677.1 - 3.1e-05 23.8 0.2 0.00011 22.1 0.2 2.0 1 0 0 1 1 1 1 F-box LRR_6 PF13516.6 CDW54677.1 - 0.00011 22.0 4.0 7.5 6.9 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich repeat FBD PF08387.10 CDW54677.1 - 0.17 11.8 4.9 0.24 11.3 0.0 3.6 4 1 0 4 4 4 0 FBD AAA PF00004.29 CDW54678.1 - 1.1e-40 139.1 0.0 2.1e-40 138.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW54678.1 - 4.9e-10 39.1 0.2 8.5e-10 38.3 0.2 1.4 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDW54678.1 - 9.1e-08 31.9 0.0 2e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 CDW54678.1 - 1.7e-05 25.0 0.0 3.7e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDW54678.1 - 2e-05 24.9 0.3 0.014 15.7 0.3 2.7 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDW54678.1 - 2.5e-05 23.5 0.0 4.6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 CDW54678.1 - 0.00045 20.2 0.2 0.0024 17.9 0.2 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDW54678.1 - 0.00077 19.2 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDW54678.1 - 0.0017 18.8 0.1 0.011 16.2 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain Prot_ATP_OB_N PF17758.1 CDW54678.1 - 0.0053 16.4 0.1 0.017 14.7 0.0 1.9 2 0 0 2 2 1 1 Proteasomal ATPase OB N-terminal domain ATPase PF06745.13 CDW54678.1 - 0.0054 16.1 0.1 0.42 9.9 0.1 2.2 1 1 1 2 2 2 1 KaiC AAA_28 PF13521.6 CDW54678.1 - 0.0081 16.4 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDW54678.1 - 0.01 16.0 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDW54678.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 CDW54678.1 - 0.021 14.1 0.1 0.042 13.0 0.0 1.4 1 1 1 2 2 2 0 TIP49 P-loop domain RNA_helicase PF00910.22 CDW54678.1 - 0.027 14.9 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 CDW54678.1 - 0.028 14.3 0.0 0.067 13.1 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDW54678.1 - 0.046 13.1 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CDW54678.1 - 0.064 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 CDW54678.1 - 0.073 12.8 0.4 0.26 11.0 0.3 2.0 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 CDW54678.1 - 0.083 12.3 0.2 0.29 10.6 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_18 PF13238.6 CDW54678.1 - 0.1 13.2 0.0 0.24 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDW54678.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 CDW54678.1 - 0.17 12.4 0.1 0.62 10.6 0.1 2.1 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 CDW54678.1 - 0.18 11.4 2.7 1.5 8.4 0.3 2.6 2 1 1 3 3 3 0 AAA domain NB-ARC PF00931.22 CDW54678.1 - 0.18 10.9 0.0 0.66 9.1 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain PH PF00169.29 CDW54680.1 - 7.3e-16 58.6 0.1 1.5e-15 57.6 0.1 1.5 1 0 0 1 1 1 1 PH domain GLTP PF08718.11 CDW54680.1 - 6.6e-10 39.4 0.6 7.5e-09 36.0 0.3 2.1 2 0 0 2 2 2 1 Glycolipid transfer protein (GLTP) PH_11 PF15413.6 CDW54680.1 - 0.03 14.8 1.1 0.38 11.2 0.1 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.6 CDW54680.1 - 0.062 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain UQ_con PF00179.26 CDW54681.1 - 1.2e-16 60.6 0.0 2.8e-16 59.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDW54681.1 - 0.02 15.2 0.1 0.026 14.8 0.1 1.4 1 1 0 1 1 1 0 RWD domain Hormone_recep PF00104.30 CDW54682.1 - 2e-32 112.5 0.2 3.4e-32 111.7 0.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 CDW54682.1 - 1.5e-29 102.2 18.6 5.5e-29 100.4 18.6 2.0 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Asp PF00026.23 CDW54684.1 - 1.2e-18 67.7 0.0 1.5e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease PHO4 PF01384.20 CDW54685.1 - 2.6e-113 378.5 19.4 3.1e-113 378.3 19.4 1.1 1 0 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.10 CDW54685.1 - 0.15 11.9 0.0 27 4.6 0.0 2.9 3 0 0 3 3 3 0 IclR helix-turn-helix domain RGS PF00615.19 CDW54686.1 - 3.1e-17 62.9 1.1 3.1e-17 62.9 1.1 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Axin_b-cat_bind PF08833.10 CDW54686.1 - 9.4e-17 60.8 0.9 2e-16 59.8 0.1 2.1 2 0 0 2 2 2 1 Axin beta-catenin binding domain SLC35F PF06027.12 CDW54689.1 - 1.9e-87 293.5 26.7 2.7e-76 257.0 6.5 2.2 2 0 0 2 2 2 2 Solute carrier family 35 CRT-like PF08627.10 CDW54689.1 - 2.7e-08 33.1 2.7 2.7e-08 33.1 2.7 2.0 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 CDW54689.1 - 0.0012 19.0 9.1 0.0012 19.0 9.1 3.3 2 1 0 2 2 2 1 EamA-like transporter family zf-RING_2 PF13639.6 CDW54691.1 - 2.2e-12 47.1 6.3 4e-12 46.3 6.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CDW54691.1 - 4.2e-11 42.4 4.7 4.2e-11 42.4 4.7 2.3 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDW54691.1 - 1e-07 31.7 6.4 1.8e-07 30.9 6.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW54691.1 - 1.6e-07 31.2 2.3 4.4e-07 29.8 2.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 CDW54691.1 - 1e-06 28.9 7.1 1e-06 28.9 7.1 1.9 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CDW54691.1 - 1.1e-06 28.4 2.9 1.9e-06 27.6 2.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW54691.1 - 1.7e-06 27.8 5.9 3.7e-06 26.7 5.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW54691.1 - 1.3e-05 25.1 3.5 1.3e-05 25.1 3.5 1.6 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDW54691.1 - 0.00086 19.1 1.9 0.0016 18.3 1.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 CDW54691.1 - 0.00087 18.9 3.7 0.00087 18.9 3.7 1.8 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 CDW54691.1 - 0.0042 17.2 2.7 0.0042 17.2 2.7 2.6 1 1 1 2 2 2 1 FANCL C-terminal domain DNA_ligase_ZBD PF03119.16 CDW54691.1 - 0.017 15.2 3.0 0.24 11.5 0.0 2.5 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Prok-RING_1 PF14446.6 CDW54691.1 - 0.041 13.8 3.0 0.11 12.5 1.1 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-ANAPC11 PF12861.7 CDW54691.1 - 0.093 12.8 8.7 1.4 9.0 7.1 2.8 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 CDW54691.1 - 0.35 11.1 8.6 0.56 10.4 6.3 2.4 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 CDW54691.1 - 3 8.0 8.7 8.2 6.6 6.4 2.4 1 1 1 2 2 2 0 RING-variant domain SKICH PF17751.1 CDW54692.1 - 2.3e-08 34.5 0.0 5.2e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 SKICH domain DnaJ PF00226.31 CDW54693.1 - 0.0076 16.4 0.2 0.028 14.5 0.2 2.0 1 0 0 1 1 1 1 DnaJ domain MSV199 PF10553.9 CDW54693.1 - 0.046 14.0 0.1 0.081 13.2 0.1 1.4 1 0 0 1 1 1 0 MSV199 domain GDA1_CD39 PF01150.17 CDW54694.1 - 2.1e-76 257.3 0.0 2.8e-76 256.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF3566 PF12089.8 CDW54694.1 - 5.5 7.4 6.5 15 5.9 2.5 2.3 2 0 0 2 2 2 0 Transmembrane domain of unknown function (DUF3566) GTP_EFTU PF00009.27 CDW54695.1 - 2.4e-59 200.2 0.0 3.8e-59 199.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDW54695.1 - 2.5e-35 120.9 0.0 6.6e-35 119.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 CDW54695.1 - 2.7e-27 94.7 0.0 5e-27 93.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDW54695.1 - 4e-21 74.8 0.0 8.5e-21 73.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDW54695.1 - 3.4e-13 49.8 0.0 7.5e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDW54695.1 - 9.9e-09 35.1 0.0 2.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 CDW54695.1 - 0.011 16.2 0.0 0.38 11.3 0.0 2.6 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain AIG1 PF04548.16 CDW54695.1 - 0.017 14.5 0.0 0.038 13.3 0.0 1.5 1 0 0 1 1 1 0 AIG1 family MMR_HSR1 PF01926.23 CDW54695.1 - 0.046 13.8 0.0 0.099 12.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Forkhead PF00250.18 CDW54696.1 - 1.4e-29 102.1 0.1 2.6e-29 101.3 0.1 1.4 1 0 0 1 1 1 1 Forkhead domain Ribosomal_S21 PF01165.20 CDW54696.1 - 0.11 12.3 0.3 0.25 11.1 0.3 1.6 1 0 0 1 1 1 0 Ribosomal protein S21 Ribosomal_S17e PF00833.18 CDW54697.1 - 7e-57 190.6 0.8 8.6e-57 190.3 0.8 1.1 1 0 0 1 1 1 1 Ribosomal S17 SIKE PF05769.11 CDW54698.1 - 0.024 14.5 0.3 0.045 13.7 0.3 1.4 1 0 0 1 1 1 0 SIKE family DSPc PF00782.20 CDW54699.1 - 2e-13 50.3 0.0 4.8e-13 49.1 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW54699.1 - 2.6e-07 30.4 0.0 3.7e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 CDW54699.1 - 0.00014 21.6 0.1 0.00035 20.3 0.0 1.7 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 CDW54699.1 - 0.0042 17.1 0.0 0.0084 16.1 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPn PF14671.6 CDW54699.1 - 0.049 14.1 0.0 0.087 13.3 0.0 1.4 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half CCER1 PF15482.6 CDW54699.1 - 2.2 8.1 4.1 3 7.7 0.2 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing glutamate-rich protein family 1 Ras PF00071.22 CDW54700.1 - 8.8e-59 197.7 0.0 1e-58 197.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW54700.1 - 4.1e-23 81.9 0.0 6.1e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW54700.1 - 7.9e-10 38.5 0.0 1.6e-09 37.5 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW54700.1 - 0.00017 21.2 0.0 0.00033 20.2 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CDW54700.1 - 0.037 13.5 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDW54700.1 - 0.059 12.7 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDW54700.1 - 0.16 11.9 0.0 0.75 9.7 0.0 2.0 2 1 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 CDW54700.1 - 0.17 11.6 0.2 3.3 7.4 0.2 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation EGF_CA PF07645.15 CDW54701.1 - 1.4e-74 246.1 111.8 1.2e-13 51.0 7.4 10.2 8 2 1 9 9 9 8 Calcium-binding EGF domain cEGF PF12662.7 CDW54701.1 - 5.8e-27 93.3 93.1 1e-08 34.9 2.1 10.9 11 1 0 11 11 11 6 Complement Clr-like EGF-like FXa_inhibition PF14670.6 CDW54701.1 - 1.4e-13 50.8 41.5 2.9e-07 30.7 6.2 11.5 12 1 1 13 13 13 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW54701.1 - 1.4e-07 31.6 95.3 0.0022 18.2 6.2 9.7 9 0 0 9 9 9 6 EGF domain EGF PF00008.27 CDW54701.1 - 0.0014 18.9 18.6 0.0046 17.2 5.1 11.8 10 3 0 10 10 10 6 EGF-like domain bZIP_2 PF07716.15 CDW54702.1 - 8.9e-16 57.7 14.9 1.3e-15 57.2 14.9 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CDW54702.1 - 3e-08 33.6 10.1 4.6e-08 33.0 10.1 1.3 1 0 0 1 1 1 1 bZIP transcription factor FAM199X PF15814.5 CDW54702.1 - 0.1 11.6 1.6 0.13 11.3 1.6 1.1 1 0 0 1 1 1 0 Protein family FAM199X Phlebovirus_NSM PF07246.11 CDW54702.1 - 0.27 10.6 2.7 0.37 10.1 2.7 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M ATP12 PF07542.11 CDW54703.1 - 6.4e-33 113.6 0.0 1.1e-32 112.8 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein DUF563 PF04577.14 CDW54703.1 - 4.2e-08 33.6 0.3 1.1e-07 32.2 0.1 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF563) NDUFA12 PF05071.16 CDW54703.1 - 0.0058 17.4 0.5 0.02 15.7 0.5 2.0 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 CagY_M PF07337.11 CDW54704.1 - 0.03 13.9 0.0 0.08 12.6 0.0 1.7 1 0 0 1 1 1 0 DC-EC Repeat DUF373 PF04123.13 CDW54704.1 - 0.75 9.2 8.2 0.99 8.8 7.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF373) CBM_14 PF01607.24 CDW54705.1 - 0.015 15.5 1.0 0.16 12.2 0.4 2.2 2 0 0 2 2 2 0 Chitin binding Peritrophin-A domain NopRA1 PF16201.5 CDW54706.1 - 4.2e-46 157.1 1.8 8.4e-46 156.1 0.6 2.2 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 Npa1 PF11707.8 CDW54706.1 - 1.2e-06 28.2 1.2 3.3e-06 26.7 0.4 2.1 2 0 0 2 2 2 1 Ribosome 60S biogenesis N-terminal F-box-like_2 PF13013.6 CDW54706.1 - 0.094 12.7 0.4 0.74 9.8 0.1 2.6 2 0 0 2 2 2 0 F-box-like domain UCH PF00443.29 CDW54707.1 - 5e-51 173.7 0.0 6.6e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW54707.1 - 5.7e-14 52.4 0.1 4.5e-10 39.6 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Jiv90 PF14901.6 CDW54707.1 - 0.17 12.0 0.5 0.98 9.6 0.2 2.1 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone zf-ribbon_3 PF13248.6 CDW54707.1 - 0.18 11.2 1.8 12 5.5 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf_UBZ PF18439.1 CDW54707.1 - 0.27 10.9 2.4 8.6 6.1 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-U1 PF06220.12 CDW54708.1 - 4.8e-23 80.6 4.4 6.6e-23 80.2 4.4 1.2 1 0 0 1 1 1 1 U1 zinc finger ESSS PF10183.9 CDW54709.1 - 1.8e-08 34.5 0.2 2.1e-08 34.3 0.2 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Thyroglobulin_1 PF00086.18 CDW54710.1 - 2.9e-30 103.7 23.0 1.4e-16 59.9 1.3 3.4 4 0 0 4 4 4 2 Thyroglobulin type-1 repeat SPARC_Ca_bdg PF10591.9 CDW54710.1 - 1.2e-27 96.4 4.0 3.4e-14 53.1 0.2 2.5 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_1 PF00036.32 CDW54710.1 - 3.7e-12 44.9 0.1 0.097 12.3 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDW54710.1 - 1.1e-11 45.0 0.4 3.1e-06 27.5 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW54710.1 - 7.2e-09 34.9 0.2 0.28 11.2 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 CDW54710.1 - 2.8e-07 29.7 0.1 0.0022 17.4 0.0 4.1 4 0 0 4 4 4 1 EF hand Kazal_2 PF07648.15 CDW54710.1 - 4e-07 30.1 3.0 1.4e-06 28.3 1.4 2.9 1 1 1 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 CDW54710.1 - 5e-05 23.2 2.1 5e-05 23.2 2.1 4.5 4 0 0 4 4 4 1 Kazal-type serine protease inhibitor domain Dockerin_1 PF00404.18 CDW54710.1 - 0.034 14.3 0.0 0.71 10.1 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain LEA_3 PF03242.13 CDW54710.1 - 0.29 11.9 1.4 32 5.3 0.1 2.7 2 1 1 3 3 3 0 Late embryogenesis abundant protein HLH PF00010.26 CDW54711.1 - 1e-16 60.6 1.4 1.5e-16 60.1 1.4 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Vps54 PF07928.12 CDW54712.1 - 7.9e-40 136.4 1.8 7.9e-40 136.4 1.8 3.1 3 0 0 3 3 3 1 Vps54-like protein Vps54_N PF10475.9 CDW54712.1 - 4.9e-08 32.6 9.8 1.5e-05 24.4 2.9 2.6 1 1 1 2 2 2 2 Vacuolar-sorting protein 54, of GARP complex CREPT PF16566.5 CDW54712.1 - 1.5 9.0 4.6 2.2 8.4 1.0 3.0 3 1 1 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour TB2_DP1_HVA22 PF03134.19 CDW54713.1 - 6.6e-28 96.5 6.4 6.6e-28 96.5 6.4 1.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family MFS_1 PF07690.16 CDW54714.1 - 9.9e-24 83.9 47.1 1.8e-10 40.3 20.9 3.2 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_1_like PF12832.7 CDW54714.1 - 1.2e-05 24.4 10.5 0.0013 17.6 0.6 3.7 1 1 0 2 2 2 2 MFS_1 like family Herpes_pp38 PF04846.13 CDW54714.1 - 6.3 6.8 9.5 0.99 9.4 2.1 3.2 4 0 0 4 4 4 0 Herpesvirus pp38 phosphoprotein COesterase PF00135.28 CDW54715.1 - 1.2e-116 390.6 0.0 6.9e-116 388.1 0.0 1.8 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW54715.1 - 5.9e-09 36.1 0.0 1.4e-08 34.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold CRCB PF02537.15 CDW54715.1 - 0.02 15.2 0.2 0.02 15.2 0.2 1.8 2 0 0 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) Peptidase_S9 PF00326.21 CDW54715.1 - 0.13 11.8 0.0 0.63 9.5 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family Esterase PF00756.20 CDW54715.1 - 0.14 11.8 0.1 0.66 9.6 0.0 1.9 2 0 0 2 2 2 0 Putative esterase Pkinase PF00069.25 CDW54717.1 - 3e-59 200.6 0.0 4.1e-59 200.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C1_1 PF00130.22 CDW54717.1 - 8.1e-35 118.5 24.4 2.3e-17 62.6 6.8 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 CDW54717.1 - 4.8e-31 108.0 0.0 7.1e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CDW54717.1 - 2.9e-07 31.1 2.0 5.9e-07 30.1 2.0 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 CDW54717.1 - 0.00029 20.3 0.0 0.0005 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like C1_2 PF03107.16 CDW54717.1 - 0.0012 19.2 13.5 0.16 12.3 2.3 2.5 2 0 0 2 2 2 2 C1 domain Haspin_kinase PF12330.8 CDW54717.1 - 0.0016 17.4 0.0 0.0026 16.8 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDW54717.1 - 0.0039 17.2 0.4 0.017 15.0 0.4 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 CDW54717.1 - 0.017 14.7 0.2 3.1 7.3 0.1 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDW54717.1 - 0.037 13.4 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Zf_RING PF16744.5 CDW54717.1 - 0.038 14.1 11.2 0.1 12.7 3.1 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger FAD_binding_2 PF00890.24 CDW54717.1 - 0.048 12.7 0.0 0.076 12.1 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain FYVE_2 PF02318.16 CDW54717.1 - 0.082 13.1 10.2 1 9.6 2.1 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger RIO1 PF01163.22 CDW54717.1 - 0.18 11.4 0.0 0.36 10.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family PHD PF00628.29 CDW54717.1 - 0.33 10.9 20.0 0.85 9.6 5.5 2.5 2 0 0 2 2 2 0 PHD-finger zf-RING_9 PF13901.6 CDW54717.1 - 0.4 10.6 17.0 1.3 9.0 4.6 2.3 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon zf-RING-like PF08746.11 CDW54717.1 - 2 8.8 22.6 1.1 9.6 6.0 2.7 2 0 0 2 2 2 0 RING-like domain FYVE PF01363.21 CDW54717.1 - 4.2 7.6 11.9 0.58 10.3 1.9 2.4 2 0 0 2 2 2 0 FYVE zinc finger PHD_4 PF16866.5 CDW54717.1 - 6.3 7.0 9.1 14 5.8 1.0 2.7 2 0 0 2 2 2 0 PHD-finger DUF229 PF02995.17 CDW54718.1 - 4.5e-98 329.0 2.7 8.2e-98 328.2 0.5 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 CDW54718.1 - 0.0021 17.7 0.0 0.033 13.8 0.0 2.2 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CDW54718.1 - 0.0074 15.7 0.6 0.013 15.0 0.6 1.5 1 1 0 1 1 1 1 Sulfatase DUF3884 PF13024.6 CDW54718.1 - 0.08 12.5 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) C2 PF00168.30 CDW54719.1 - 2.3e-14 53.5 0.0 2.8e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 C2 domain Vps16_C PF04840.12 CDW54720.1 - 9.3e-09 34.8 0.9 7.4e-08 31.8 0.9 2.1 1 1 0 1 1 1 1 Vps16, C-terminal region FKBP_C PF00254.28 CDW54721.1 - 7.2e-47 157.7 0.2 3e-30 104.4 0.0 2.5 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 CDW54721.1 - 1.5e-13 49.9 8.5 1.5e-05 24.6 1.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDW54721.1 - 2.8e-12 45.7 6.2 6.6e-06 25.9 1.9 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 CDW54721.1 - 5.6e-08 32.3 2.1 0.0038 17.1 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW54721.1 - 3.5e-07 30.2 3.3 0.0053 16.8 0.7 3.3 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 CDW54721.1 - 4.4e-07 30.4 2.7 0.0024 18.5 2.3 2.9 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW54721.1 - 9.6e-07 29.1 0.7 0.015 16.0 2.3 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat FKBP_N_2 PF18023.1 CDW54721.1 - 1.4e-06 28.4 0.0 0.04 14.0 0.0 3.0 2 2 0 2 2 2 2 BDBT FKBP like N-terminal TPR_6 PF13174.6 CDW54721.1 - 3.1e-06 27.5 1.4 0.041 14.5 1.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW54721.1 - 3.1e-06 27.6 4.4 0.055 14.0 0.3 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW54721.1 - 6.9e-06 26.1 0.1 3.5e-05 23.9 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW54721.1 - 1.1e-05 24.9 6.8 0.36 10.6 2.8 3.3 2 1 1 3 3 3 3 TPR repeat TPR_8 PF13181.6 CDW54721.1 - 1.3e-05 25.1 4.9 0.0044 17.1 0.4 3.6 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDW54721.1 - 0.00046 20.4 0.5 0.25 11.8 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDW54721.1 - 0.0018 18.5 5.6 0.43 10.9 0.8 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF4145 PF13643.6 CDW54721.1 - 0.04 14.0 0.2 0.15 12.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) NOD2_WH PF17779.1 CDW54721.1 - 0.07 13.5 0.1 0.55 10.6 0.0 2.4 2 0 0 2 2 2 0 NOD2 winged helix domain Alkyl_sulf_dimr PF14863.6 CDW54721.1 - 0.23 11.9 3.4 12 6.3 0.1 2.4 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation ANAPC3 PF12895.7 CDW54721.1 - 0.27 11.5 3.1 0.3 11.4 0.9 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Beta_helix PF13229.6 CDW54722.1 - 1.2e-65 220.2 53.9 2.7e-27 95.5 15.5 4.5 1 1 3 4 4 4 3 Right handed beta helix region NosD PF05048.13 CDW54722.1 - 1.6e-37 129.1 32.3 2.4e-16 59.8 7.5 4.3 1 1 3 4 4 4 4 Periplasmic copper-binding protein (NosD) F-box-like PF12937.7 CDW54722.1 - 1.1e-15 57.2 0.8 2e-15 56.4 0.8 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDW54722.1 - 3.9e-12 45.7 4.8 7e-12 44.9 4.8 1.5 1 0 0 1 1 1 1 F-box domain zf-UBR PF02207.20 CDW54722.1 - 9.1e-08 32.2 19.9 2.5e-07 30.7 19.9 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) GIT1_C PF12205.8 CDW54723.1 - 3.8e-27 94.7 1.3 1.1e-26 93.2 1.3 1.8 1 0 0 1 1 1 1 G protein-coupled receptor kinase-interacting protein 1 C term ArfGap PF01412.18 CDW54723.1 - 2.3e-26 92.2 4.0 1.1e-25 90.0 3.1 2.3 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf GIT_SHD PF08518.11 CDW54723.1 - 1.4e-18 66.2 7.9 2.5e-09 36.6 3.0 2.8 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Ank_2 PF12796.7 CDW54723.1 - 0.004 17.7 0.0 0.012 16.2 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDW54723.1 - 0.11 13.0 0.0 0.33 11.5 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeat Ank_4 PF13637.6 CDW54723.1 - 0.15 12.7 0.0 1.7 9.3 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) BAH PF01426.18 CDW54724.1 - 2.3e-21 75.9 0.0 1.7e-20 73.1 0.0 2.3 1 1 0 1 1 1 1 BAH domain MTA_R1 PF17226.2 CDW54724.1 - 1.6e-11 44.2 0.2 3.7e-11 43.0 0.2 1.7 1 0 0 1 1 1 1 MTA R1 domain ELM2 PF01448.24 CDW54724.1 - 1.1e-08 35.7 0.0 3.4e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 ELM2 domain GATA PF00320.27 CDW54724.1 - 4.7e-06 26.1 5.6 8.7e-06 25.2 5.6 1.5 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-binding PF00249.31 CDW54724.1 - 9.7e-06 25.7 0.1 9.7e-06 25.7 0.1 2.9 4 0 0 4 4 4 1 Myb-like DNA-binding domain zf-C2H2 PF00096.26 CDW54724.1 - 0.0077 16.6 0.2 0.0077 16.6 0.2 2.5 3 0 0 3 3 3 1 Zinc finger, C2H2 type Myb_DNA-bind_7 PF15963.5 CDW54724.1 - 0.0081 16.0 0.2 0.019 14.8 0.2 1.6 1 0 0 1 1 1 1 Myb DNA-binding like zf-C2H2_4 PF13894.6 CDW54724.1 - 0.26 12.2 0.2 0.26 12.2 0.2 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger UMP1 PF05348.11 CDW54725.1 - 3.1e-06 27.4 0.0 3.7e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 JmjC PF02373.22 CDW54726.1 - 1.5e-42 144.6 0.7 2.9e-42 143.7 0.7 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 CDW54726.1 - 7.1e-18 65.1 0.4 1.6e-17 63.9 0.4 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 CDW54726.1 - 1.4e-11 44.1 0.1 3.1e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 CDW54726.1 - 8.8e-11 41.5 4.4 8.8e-11 41.5 4.4 2.7 2 0 0 2 2 2 1 PHD-finger zf-C5HC2 PF02928.16 CDW54726.1 - 1.2e-08 35.2 12.6 1.2e-08 35.2 12.6 3.2 4 0 0 4 4 4 1 C5HC2 zinc finger PHD_2 PF13831.6 CDW54726.1 - 7.7e-05 22.2 1.4 7.7e-05 22.2 1.4 2.9 2 0 0 2 2 2 1 PHD-finger C1_2 PF03107.16 CDW54726.1 - 0.025 14.9 13.6 0.13 12.6 3.7 3.3 2 0 0 2 2 2 0 C1 domain ORC5_C PF14630.6 CDW54727.1 - 1.7e-29 103.2 0.0 2.1e-29 103.0 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AMP-binding PF00501.28 CDW54728.1 - 5e-92 308.7 0.0 9e-92 307.9 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW54728.1 - 0.00015 22.7 0.0 0.00048 21.1 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain CDC48_2 PF02933.17 CDW54728.1 - 0.18 11.6 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 Ribosomal_L34e PF01199.18 CDW54729.1 - 4.4e-41 139.1 4.5 6.7e-41 138.5 4.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L34e zf-UDP PF14569.6 CDW54729.1 - 0.021 15.0 2.0 0.34 11.0 0.2 2.2 2 0 0 2 2 2 0 Zinc-binding RING-finger SKIP_SNW PF02731.15 CDW54731.1 - 1.2e-73 246.1 8.6 1.2e-73 246.1 8.6 1.7 2 0 0 2 2 2 1 SKIP/SNW domain Takusan PF04822.13 CDW54731.1 - 1.8 8.5 9.6 13 5.8 10.4 2.0 2 0 0 2 2 2 0 Takusan Tyr-DNA_phospho PF06087.12 CDW54732.1 - 1.3e-92 311.0 0.0 2.8e-63 214.3 0.0 2.0 2 0 0 2 2 2 2 Tyrosyl-DNA phosphodiesterase Glyco_transf_90 PF05686.12 CDW54734.1 - 6.1e-71 239.4 3.8 8.1e-71 239.0 3.8 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Filamin PF00630.19 CDW54734.1 - 0.0012 19.6 0.0 0.0027 18.5 0.0 1.6 1 0 0 1 1 1 1 Filamin/ABP280 repeat DUF4600 PF15372.6 CDW54734.1 - 0.14 12.6 0.4 5.3 7.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) Glyco_trans_1_2 PF13524.6 CDW54734.1 - 0.19 12.1 0.0 0.39 11.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 TFIIF_alpha PF05793.12 CDW54735.1 - 1.1e-89 301.5 47.1 2.9e-61 207.7 4.0 2.9 2 1 0 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Med8 PF10232.9 CDW54735.1 - 3.2 7.3 10.5 17 4.9 10.5 2.2 1 1 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 PIP5K PF01504.18 CDW54736.1 - 8.2e-44 149.9 1.4 1.8e-33 115.9 1.1 2.3 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 CDW54736.1 - 1.2e-16 60.4 0.1 2.9e-16 59.2 0.1 1.5 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 CDW54736.1 - 8.8e-15 54.6 16.8 8.8e-15 54.6 16.8 3.9 5 0 0 5 5 5 1 FYVE zinc finger EDR1 PF14381.6 CDW54736.1 - 0.026 14.2 0.3 0.067 12.9 0.3 1.6 1 0 0 1 1 1 0 Ethylene-responsive protein kinase Le-CTR1 Fzo_mitofusin PF04799.13 CDW54736.1 - 0.099 12.2 2.2 0.27 10.8 2.2 1.7 1 0 0 1 1 1 0 fzo-like conserved region F-box-like PF12937.7 CDW54737.1 - 0.00014 21.7 0.1 0.00038 20.3 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDW54737.1 - 0.00061 19.6 0.1 0.0017 18.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain TFIID_30kDa PF03540.13 CDW54738.1 - 3.8e-16 58.7 0.3 5.6e-16 58.2 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit GST_C_2 PF13410.6 CDW54739.1 - 1.3e-07 31.5 0.0 2.3e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CDW54739.1 - 4.6e-06 26.9 0.0 9.6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CDW54739.1 - 0.006 16.7 0.0 0.012 15.8 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CDW54739.1 - 0.015 15.0 0.1 0.028 14.2 0.1 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF3973 PF13119.6 CDW54739.1 - 0.033 14.3 0.2 0.078 13.1 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3973) LCM PF04072.14 CDW54740.1 - 5.9e-21 75.3 0.0 1.1e-20 74.4 0.0 1.5 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Methyltransf_19 PF04672.12 CDW54740.1 - 0.018 14.5 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl methyltransferase Arm PF00514.23 CDW54741.1 - 1.4e-68 225.0 20.4 1.7e-13 50.1 0.3 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CDW54741.1 - 1.6e-25 89.2 4.0 4.8e-10 39.7 0.1 6.6 6 1 1 7 7 7 4 HEAT-like repeat Arm_3 PF16186.5 CDW54741.1 - 5.6e-22 77.1 0.2 1.6e-18 66.0 0.2 2.5 2 0 0 2 2 2 2 Atypical Arm repeat HEAT_2 PF13646.6 CDW54741.1 - 4.8e-17 62.1 0.1 1.6e-05 25.2 0.0 5.6 2 2 4 6 6 6 6 HEAT repeats HEAT PF02985.22 CDW54741.1 - 1.7e-15 55.7 5.2 0.00051 20.1 0.0 6.9 7 1 1 8 8 7 3 HEAT repeat IBB PF01749.20 CDW54741.1 - 3e-09 37.2 3.6 3.7e-09 36.9 1.2 2.4 2 0 0 2 2 2 1 Importin beta binding domain Adaptin_N PF01602.20 CDW54741.1 - 5.6e-07 28.5 1.2 2.8e-06 26.2 1.0 1.9 1 1 0 1 1 1 1 Adaptin N terminal region Arm_2 PF04826.13 CDW54741.1 - 4.9e-05 22.9 1.4 0.093 12.2 0.2 3.6 1 1 2 3 3 3 3 Armadillo-like Cnd1 PF12717.7 CDW54741.1 - 0.00015 21.9 4.1 2 8.4 0.0 4.3 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 CDW54741.1 - 0.00027 21.0 1.6 1.3 9.1 0.1 3.8 3 1 1 4 4 4 2 V-ATPase subunit H Atx10homo_assoc PF09759.9 CDW54741.1 - 0.0011 19.0 3.5 0.067 13.2 0.0 4.1 3 2 2 5 5 5 1 Spinocerebellar ataxia type 10 protein domain DRIM PF07539.12 CDW54741.1 - 0.015 13.6 0.2 0.49 8.6 0.0 2.3 2 0 0 2 2 2 0 Down-regulated in metastasis MMS19_N PF14500.6 CDW54741.1 - 0.078 12.5 0.0 0.33 10.5 0.0 2.1 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Abhydrolase_3 PF07859.13 CDW54742.1 - 8.7e-54 182.6 0.0 1.4e-39 136.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold COesterase PF00135.28 CDW54742.1 - 3.4e-08 32.8 0.2 2.8e-07 29.8 0.2 1.9 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 CDW54742.1 - 1.9e-05 23.7 0.2 0.00015 20.8 0.2 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 CDW54742.1 - 0.071 12.6 0.0 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase family TB2_DP1_HVA22 PF03134.19 CDW54743.1 - 4.3e-28 97.1 6.3 4.3e-28 97.1 6.3 1.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Lamp PF01299.17 CDW54744.1 - 0.012 15.5 0.0 0.031 14.1 0.0 1.7 1 1 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) OATP PF03137.20 CDW54745.1 - 3.3e-125 418.5 28.5 3.1e-124 415.2 28.5 1.9 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 CDW54745.1 - 1.2e-18 67.2 40.0 5.6e-17 61.7 32.5 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily PDZ PF00595.24 CDW54746.1 - 6.6e-75 247.5 8.7 2.5e-21 75.8 0.1 4.5 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 CDW54746.1 - 3e-38 129.4 6.9 5.6e-10 38.9 0.0 4.9 5 0 0 5 5 5 4 PDZ domain LRR_8 PF13855.6 CDW54746.1 - 2.8e-30 103.9 31.3 1.6e-10 40.5 1.2 7.3 3 2 4 7 7 7 6 Leucine rich repeat PDZ_2 PF13180.6 CDW54746.1 - 4.2e-21 75.0 1.3 2.2e-05 24.7 0.0 5.1 4 0 0 4 4 4 4 PDZ domain LRR_4 PF12799.7 CDW54746.1 - 4.1e-15 55.6 37.8 0.0041 17.5 0.1 8.5 4 2 6 10 10 10 9 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDW54746.1 - 0.014 15.4 9.3 8.3 6.8 0.0 6.0 5 0 0 5 5 5 0 Leucine Rich repeat LRR_5 PF13306.6 CDW54746.1 - 0.014 15.3 0.0 0.26 11.2 0.0 2.5 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) PDZ_4 PF17816.1 CDW54746.1 - 0.14 12.5 0.1 89 3.5 0.0 4.1 4 0 0 4 4 4 0 PDZ domain LRR_1 PF00560.33 CDW54746.1 - 0.72 10.6 18.0 2.5e+02 2.9 0.0 8.7 8 1 0 8 8 8 0 Leucine Rich Repeat Dynactin_p22 PF07426.11 CDW54746.1 - 4.5 7.1 8.3 2.4 8.0 0.2 3.2 3 0 0 3 3 3 0 Dynactin subunit p22 PPR_2 PF13041.6 CDW54747.1 - 1.5e-13 50.7 13.2 2.7e-06 27.5 0.1 9.5 10 1 2 12 12 12 3 PPR repeat family PPR_3 PF13812.6 CDW54747.1 - 1.6e-12 47.3 0.3 0.00011 22.3 0.0 5.1 3 1 2 5 5 5 3 Pentatricopeptide repeat domain PPR PF01535.20 CDW54747.1 - 3e-10 39.6 14.6 0.041 14.1 0.0 9.2 9 0 0 9 9 9 3 PPR repeat PPR_long PF17177.4 CDW54747.1 - 5.7e-07 29.1 2.5 4.7e-06 26.1 0.2 3.6 4 1 1 5 5 5 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 CDW54747.1 - 5e-06 26.1 6.9 0.00027 20.6 0.0 5.5 7 0 0 7 7 7 1 PPR repeat LppC PF04348.13 CDW54747.1 - 0.0005 19.0 0.0 0.00086 18.2 0.0 1.3 1 0 0 1 1 1 1 LppC putative lipoprotein TPR_19 PF14559.6 CDW54747.1 - 0.00091 19.7 11.1 24 5.5 0.0 8.4 7 2 1 9 9 9 0 Tetratricopeptide repeat Gasdermin_C PF17708.1 CDW54747.1 - 0.0085 16.2 0.1 1.9 8.6 0.1 2.7 2 0 0 2 2 2 1 Gasdermin PUB domain TPR_16 PF13432.6 CDW54747.1 - 0.071 13.8 1.8 62 4.4 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDW54747.1 - 0.61 10.9 5.7 1.5 9.6 0.2 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDW54747.1 - 0.9 10.5 14.1 2.2 9.3 0.1 7.2 8 0 0 8 8 7 0 Tetratricopeptide repeat 7tm_1 PF00001.21 CDW54748.1 - 4.5e-64 216.3 12.8 8.3e-64 215.4 12.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW54748.1 - 3.4e-08 33.2 16.2 3.1e-07 30.0 8.3 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW54748.1 - 2.1e-05 24.3 10.5 2.1e-05 24.3 10.5 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srbc PF10316.9 CDW54748.1 - 3.8e-05 23.3 5.8 7.9e-05 22.3 5.8 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 CDW54748.1 - 0.00013 21.8 5.5 0.00013 21.8 5.5 2.3 2 1 0 2 2 2 1 Olfactory receptor Syntaxin PF00804.25 CDW54748.1 - 0.13 12.0 3.9 0.1 12.3 0.2 2.2 2 0 0 2 2 2 0 Syntaxin DUF2207 PF09972.9 CDW54748.1 - 2.4 6.8 9.7 11 4.6 1.0 3.0 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF3325 PF11804.8 CDW54748.1 - 5.2 7.3 7.7 28 4.9 0.6 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3325) Acetyltransf_18 PF18014.1 CDW54749.1 - 1.1e-15 57.5 0.0 1.7e-15 56.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Guanylate_kin PF00625.21 CDW54750.1 - 3.2e-59 199.7 0.0 5.2e-59 199.0 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase Pkinase PF00069.25 CDW54750.1 - 9.2e-47 159.6 0.0 1.6e-46 158.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54750.1 - 3.8e-21 75.5 0.0 6.4e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.24 CDW54750.1 - 1.9e-12 47.3 0.2 4.3e-12 46.2 0.2 1.6 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.17 CDW54750.1 - 1.2e-06 28.1 0.0 3.6e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW54750.1 - 3.1e-05 23.5 0.4 0.00012 21.6 0.4 2.0 1 1 0 1 1 1 1 SH3 domain PDZ_6 PF17820.1 CDW54750.1 - 0.0004 20.2 0.0 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 PDZ domain Pkinase_fungal PF17667.1 CDW54750.1 - 0.014 14.2 0.0 0.025 13.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 CDW54750.1 - 0.042 13.2 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 Kinase-like SH3_9 PF14604.6 CDW54750.1 - 0.11 12.3 0.1 0.45 10.4 0.0 2.0 2 0 0 2 2 2 0 Variant SH3 domain Homeodomain PF00046.29 CDW54751.1 - 6e-21 74.1 0.4 6e-21 74.1 0.4 1.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW54751.1 - 0.82 9.6 2.9 1.3 9.0 0.0 2.6 3 0 0 3 3 3 0 Homeobox KN domain Homeodomain PF00046.29 CDW54752.1 - 1.6e-21 75.9 2.0 1.6e-21 75.9 2.0 1.8 2 0 0 2 2 2 1 Homeodomain ARID PF01388.21 CDW54753.1 - 1.4e-16 60.9 0.0 2.3e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Mei5 PF10376.9 CDW54753.1 - 0.012 15.5 2.2 0.018 14.9 2.2 1.2 1 0 0 1 1 1 0 Double-strand recombination repair protein AF-4 PF05110.13 CDW54753.1 - 3.5 5.6 12.3 4.4 5.2 12.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Tudor-knot PF11717.8 CDW54754.1 - 0.00095 19.0 0.6 0.0026 17.6 0.1 2.0 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain CAP PF00188.26 CDW54755.1 - 4.4e-10 40.5 0.9 8.4e-10 39.6 0.9 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PRTase_3 PF15610.6 CDW54755.1 - 0.087 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 PRTase ComF-like Gal-bind_lectin PF00337.22 CDW54756.1 - 0.013 15.1 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Galactoside-binding lectin Carbpep_Y_N PF05388.11 CDW54756.1 - 0.093 13.3 2.2 0.98 10.0 0.5 2.1 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide HAT PF02184.16 CDW54757.1 - 4.8e-32 109.6 59.9 2.1e-10 40.3 4.7 13.5 13 1 0 13 13 13 8 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 CDW54757.1 - 1.5e-22 78.3 22.3 0.012 16.4 0.3 12.2 7 4 5 12 12 12 8 Tetratricopeptide repeat SNAP-25 PF00835.19 CDW54757.1 - 1.3e-17 63.8 0.0 5.2e-17 61.9 0.0 2.2 1 0 0 1 1 1 1 SNAP-25 family TPR_19 PF14559.6 CDW54757.1 - 3.1e-13 50.0 0.2 0.13 12.8 0.0 7.2 3 3 3 8 8 7 3 Tetratricopeptide repeat Suf PF05843.14 CDW54757.1 - 6.8e-12 46.0 37.1 1.6e-06 28.3 0.7 7.0 2 2 2 5 5 5 4 Suppressor of forked protein (Suf) TPR_2 PF07719.17 CDW54757.1 - 5.8e-09 35.4 14.2 0.74 10.1 0.2 9.4 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDW54757.1 - 4.1e-08 33.1 7.6 0.0041 17.4 0.0 7.4 9 0 0 9 9 7 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CDW54757.1 - 2e-06 27.8 20.1 0.0016 18.4 2.2 6.3 3 2 1 4 4 4 1 Mad3/BUB1 homology region 1 TPR_16 PF13432.6 CDW54757.1 - 0.00014 22.4 5.9 20 5.9 0.0 6.9 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW54757.1 - 0.0012 18.9 5.7 41 4.7 0.1 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDW54757.1 - 0.0017 18.6 10.9 6.7 7.1 0.1 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW54757.1 - 0.011 15.8 4.7 0.86 9.8 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Imm44 PF15571.6 CDW54757.1 - 0.097 12.9 1.8 0.21 11.9 0.2 2.5 2 0 0 2 2 1 0 Immunity protein 44 TPR_6 PF13174.6 CDW54757.1 - 0.11 13.2 10.6 1.1e+02 3.8 0.1 8.1 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDW54757.1 - 0.5 10.3 4.1 12 5.9 0.2 4.8 6 0 0 6 6 5 0 Tetratricopeptide repeat Lyase_1 PF00206.20 CDW54758.1 - 1.1e-21 77.6 0.2 1.8e-21 76.9 0.2 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 CDW54758.1 - 2.5e-08 34.3 0.1 8.1e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus Rpn9_C PF18261.1 CDW54758.1 - 0.088 12.4 0.6 0.22 11.1 0.6 1.7 1 0 0 1 1 1 0 Rpn9 C-terminal helix Peptidase_M1_N PF17900.1 CDW54760.1 - 8.4e-45 153.2 0.1 5.1e-37 127.9 0.0 2.1 1 1 1 2 2 2 2 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 CDW54760.1 - 1.1e-42 146.1 0.5 1.6e-42 145.6 0.5 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Mid2 PF04478.12 CDW54760.1 - 0.059 13.2 0.1 0.095 12.5 0.1 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Peptidase_M78 PF06114.13 CDW54760.1 - 0.19 11.7 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 IrrE N-terminal-like domain Pkinase PF00069.25 CDW54761.1 - 6.3e-25 88.0 0.0 7.6e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54761.1 - 2.2e-11 43.5 0.0 2.6e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW54761.1 - 0.00022 20.1 0.0 0.00034 19.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDW54761.1 - 0.073 12.4 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SKI PF01202.22 CDW54762.1 - 7.9e-17 61.8 0.0 9.4e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 CDW54762.1 - 2.9e-09 37.2 0.0 4.3e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDW54762.1 - 1.8e-07 31.8 0.0 2.7e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CDW54762.1 - 2.3e-06 27.6 0.0 3.4e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase Cytidylate_kin PF02224.18 CDW54762.1 - 0.00012 21.9 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase Cytidylate_kin2 PF13189.6 CDW54762.1 - 0.00029 21.0 0.0 0.00037 20.7 0.0 1.2 1 0 0 1 1 1 1 Cytidylate kinase-like family Thymidylate_kin PF02223.17 CDW54762.1 - 0.00091 18.9 0.7 0.033 13.9 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase CPT PF07931.12 CDW54762.1 - 0.0038 17.1 0.0 0.012 15.4 0.0 1.9 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein ABC_tran PF00005.27 CDW54762.1 - 0.0056 17.2 0.2 0.0097 16.4 0.2 1.5 1 1 0 1 1 1 1 ABC transporter AAA PF00004.29 CDW54762.1 - 0.0089 16.5 0.3 0.66 10.4 0.1 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 CDW54762.1 - 0.0091 16.4 0.1 0.02 15.3 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW54762.1 - 0.012 15.9 0.2 0.047 14.0 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CDW54762.1 - 0.013 15.3 2.9 0.032 14.0 2.5 2.0 2 1 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CDW54762.1 - 0.063 13.7 2.2 0.11 12.9 1.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 CDW54762.1 - 0.11 11.8 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 CDW54762.1 - 0.13 12.5 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDW54762.1 - 0.21 11.5 0.8 0.44 10.4 0.4 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 CDW54762.1 - 0.32 11.5 0.8 0.61 10.5 0.3 1.6 1 1 1 2 2 2 0 AAA domain Arf PF00025.21 CDW54764.1 - 6.5e-67 224.3 0.7 7.4e-67 224.2 0.7 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW54764.1 - 2.1e-13 50.5 0.0 3e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDW54764.1 - 1.8e-12 47.1 0.0 2.1e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CDW54764.1 - 2.1e-10 40.3 0.0 2.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CDW54764.1 - 1.5e-09 37.5 1.7 3.1e-05 23.3 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 CDW54764.1 - 5.1e-09 36.2 0.0 7.4e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW54764.1 - 1.8e-06 27.5 0.0 2.3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 CDW54764.1 - 0.0002 20.9 0.1 0.00056 19.5 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDW54764.1 - 0.0011 18.6 0.0 0.32 10.5 0.0 2.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 CDW54764.1 - 0.011 16.3 0.2 0.028 15.0 0.2 1.8 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 CDW54764.1 - 0.018 14.6 1.1 0.46 10.1 0.1 2.3 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 CDW54764.1 - 0.02 14.9 0.0 0.055 13.5 0.0 1.7 2 0 0 2 2 2 0 Dynamin family PduV-EutP PF10662.9 CDW54764.1 - 0.046 13.5 0.1 0.16 11.7 0.1 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 CDW54764.1 - 0.11 11.8 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Vert_HS_TF PF06546.11 CDW54765.1 - 0.021 14.5 0.1 0.022 14.4 0.1 1.1 1 0 0 1 1 1 0 Vertebrate heat shock transcription factor Peptidase_C54 PF03416.19 CDW54767.1 - 2.5e-97 325.6 0.0 3e-97 325.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 CDW54767.1 - 0.018 14.5 0.7 0.025 14.0 0.2 1.4 2 0 0 2 2 2 0 Peptidase family C78 EMP70 PF02990.16 CDW54768.1 - 8.2e-169 562.6 30.4 4.3e-168 560.2 30.4 1.9 1 1 0 1 1 1 1 Endomembrane protein 70 Cadherin_C_2 PF16492.5 CDW54768.1 - 9.7 7.0 7.8 19 6.1 0.0 3.5 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal PikAIV_N PF18605.1 CDW54769.1 - 0.099 12.2 0.3 0.2 11.3 0.3 1.5 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain L1R_F9L PF02442.17 CDW54771.1 - 0.0025 17.7 0.5 0.0038 17.1 0.5 1.3 1 0 0 1 1 1 1 Lipid membrane protein of large eukaryotic DNA viruses ArnB_C PF18677.1 CDW54771.1 - 0.017 15.2 0.3 0.12 12.5 0.4 2.1 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain DUF148 PF02520.17 CDW54771.1 - 0.046 13.8 0.4 0.1 12.7 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 WD40 PF00400.32 CDW54772.1 - 1.6e-08 35.0 0.7 0.00048 20.9 0.2 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat WSN PF02206.18 CDW54772.1 - 0.11 12.4 0.2 2.8 7.9 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function HEAT_2 PF13646.6 CDW54772.1 - 0.13 12.7 0.2 0.58 10.6 0.1 2.0 2 0 0 2 2 2 0 HEAT repeats L1R_F9L PF02442.17 CDW54772.1 - 0.21 11.4 0.1 0.24 11.2 0.1 1.1 1 0 0 1 1 1 0 Lipid membrane protein of large eukaryotic DNA viruses EF-hand_7 PF13499.6 CDW54773.1 - 3.2e-05 24.3 0.0 0.043 14.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW54773.1 - 0.0017 17.8 0.0 0.19 11.3 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CDW54773.1 - 0.03 14.3 0.1 0.8 9.8 0.1 2.5 3 0 0 3 3 3 0 EF-hand domain FKBP_C PF00254.28 CDW54774.1 - 0.00035 20.8 0.0 0.00072 19.8 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 PF07719.17 CDW54775.1 - 3.6e-07 29.8 0.3 0.49 10.6 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW54775.1 - 2e-05 25.0 0.0 0.018 15.8 0.0 3.3 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW54775.1 - 3.4e-05 24.2 0.0 0.072 13.6 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDW54775.1 - 9.6e-05 22.3 0.1 0.15 12.4 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW54775.1 - 0.0025 17.4 0.3 6.9 6.5 0.0 3.3 3 0 0 3 3 3 1 TPR repeat ANAPC3 PF12895.7 CDW54775.1 - 0.003 17.7 0.2 2.9 8.2 0.2 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 CDW54775.1 - 0.0074 16.9 0.0 22 5.8 0.0 3.6 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDW54775.1 - 0.0096 15.7 0.5 26 4.8 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDW54775.1 - 0.029 14.5 0.2 7.8 6.7 0.0 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat TipAS PF07739.13 CDW54775.1 - 0.11 13.1 0.1 0.37 11.3 0.0 1.8 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain ZnuA PF01297.17 CDW54775.1 - 0.2 11.0 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic XRN_N PF03159.18 CDW54776.1 - 1e-100 336.1 0.0 1.7e-100 335.4 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CDW54776.1 - 3.5e-100 336.0 2.9 2e-88 297.3 1.7 2.5 2 1 1 3 3 3 2 Xrn1 helical domain Zip PF02535.22 CDW54777.1 - 5.1e-64 216.6 21.7 6.9e-42 143.9 9.2 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter DUF726 PF05277.12 CDW54777.1 - 0.054 12.4 1.3 0.082 11.8 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF5084 PF16894.5 CDW54777.1 - 0.33 11.4 0.1 0.33 11.4 0.1 3.2 3 2 1 4 4 4 0 Domain of unknown function (DUF5084) DUF4271 PF14093.6 CDW54777.1 - 2.7 7.9 15.8 1.2 9.0 5.8 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4271) Methyltr_RsmB-F PF01189.17 CDW54778.1 - 5.6e-26 91.4 0.0 7.7e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 CDW54778.1 - 0.19 11.9 0.1 1.1 9.3 0.0 2.4 2 1 0 2 2 2 0 FtsJ-like methyltransferase FKBP_C PF00254.28 CDW54779.1 - 9.3e-14 51.5 0.0 2e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 PF13499.6 CDW54779.1 - 1.9e-13 50.6 0.8 7.5e-08 32.7 0.3 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW54779.1 - 1.2e-09 37.3 2.0 0.0077 16.1 0.0 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 CDW54779.1 - 2.6e-09 36.0 3.2 0.03 13.9 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 CDW54779.1 - 2.1e-05 23.8 2.3 0.19 11.3 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 CDW54779.1 - 0.00011 21.9 2.4 2.7 7.9 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW54779.1 - 0.044 14.1 0.3 27 5.1 0.1 3.1 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region UQ_con PF00179.26 CDW54780.1 - 1.4e-31 109.0 0.0 3.3e-31 107.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 CDW54780.1 - 0.00042 20.2 0.0 0.0072 16.2 0.0 2.4 2 0 0 2 2 2 1 UEV domain TRAM1 PF08390.11 CDW54780.1 - 0.074 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 TRAM1-like protein Pro_isomerase PF00160.21 CDW54781.1 - 1.1e-47 162.2 0.0 1.3e-47 162.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Elong_Iki1 PF10483.9 CDW54782.1 - 0.032 13.8 0.0 0.25 10.8 0.0 2.0 1 1 1 2 2 2 0 Elongator subunit Iki1 tRNA-synt_2d PF01409.20 CDW54783.1 - 1.1e-90 303.4 0.0 1.7e-90 302.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD1 PF18552.1 CDW54783.1 - 2.7e-20 71.9 1.3 4.2e-20 71.3 0.1 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 1 PheRS_DBD3 PF18553.1 CDW54783.1 - 3.1e-18 65.8 1.4 4.4e-18 65.3 0.3 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 3 PheRS_DBD2 PF18554.1 CDW54783.1 - 2e-12 46.8 0.2 4.8e-12 45.7 0.2 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA_synthFbeta PF17759.1 CDW54783.1 - 2.5e-07 30.3 0.0 3e-06 26.8 0.0 2.1 1 1 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 CDW54783.1 - 0.00076 18.7 0.1 0.0026 16.9 0.0 1.9 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 CDW54783.1 - 0.0026 17.8 0.0 0.0051 16.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) MarR_2 PF12802.7 CDW54783.1 - 0.0043 16.9 0.0 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 MarR family TrmB PF01978.19 CDW54783.1 - 0.087 12.7 0.0 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB UbiD PF01977.16 CDW54783.1 - 0.18 10.7 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Cyclin_N PF00134.23 CDW54784.1 - 5e-37 126.5 2.5 6e-35 119.8 0.6 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDW54784.1 - 2.3e-17 63.2 0.0 4.3e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain LRR_5 PF13306.6 CDW54785.1 - 0.0047 16.9 1.5 1.8 8.6 0.1 2.7 2 0 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) TetR_C_24 PF17932.1 CDW54785.1 - 0.4 11.0 2.0 18 5.6 0.1 3.0 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain TFIIE_beta PF02186.15 CDW54786.1 - 1.3e-12 47.8 0.0 2.7e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain Ish1 PF10281.9 CDW54786.1 - 0.0081 16.4 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein C2 PF00168.30 CDW54787.1 - 2.8e-12 46.8 0.0 3.5e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 C2 domain DUF229 PF02995.17 CDW54788.1 - 2e-116 389.5 0.1 2.7e-116 389.1 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 CDW54788.1 - 0.04 13.5 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase PNTB PF02233.16 CDW54789.1 - 3.5e-168 560.3 14.1 3.5e-168 560.3 14.1 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CDW54789.1 - 1.1e-76 256.9 0.7 2.2e-76 255.9 0.7 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDW54789.1 - 1.8e-43 148.1 0.0 4.6e-43 146.8 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 CDW54789.1 - 5.9e-32 110.0 2.1 5.9e-32 110.0 2.1 4.7 5 1 0 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 CDW54789.1 - 0.0048 16.3 0.2 1.6 8.1 0.2 3.3 4 0 0 4 4 4 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CDW54789.1 - 0.012 14.8 0.3 0.026 13.8 0.3 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TPP_enzyme_M PF00205.22 CDW54789.1 - 0.047 13.4 0.1 1.1 9.0 0.1 3.0 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain Phage_holin_2_4 PF16082.5 CDW54789.1 - 9.1 6.1 8.1 2.4 7.9 0.2 3.8 2 1 1 3 3 3 0 Bacteriophage holin family, superfamily II-like SEFIR PF08357.11 CDW54790.1 - 3.4e-12 46.9 0.0 6e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 SEFIR domain HPIH PF13323.6 CDW54790.1 - 0.051 13.4 0.4 0.1 12.5 0.4 1.5 1 0 0 1 1 1 0 N-terminal domain with HPIH motif Pmp3 PF01679.17 CDW54791.1 - 3.5e-20 72.0 6.1 3.8e-20 71.8 6.1 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF872 PF05915.12 CDW54791.1 - 0.21 11.7 1.3 0.24 11.6 1.3 1.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Caveolin PF01146.17 CDW54792.1 - 1.1 9.2 8.0 0.085 12.8 3.0 1.8 2 0 0 2 2 2 0 Caveolin WD40 PF00400.32 CDW54793.1 - 1.3e-22 79.6 7.8 0.00018 22.2 0.0 6.7 5 2 2 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW54793.1 - 2.5e-13 50.2 0.0 0.0013 19.0 0.0 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CDW54793.1 - 0.00015 21.6 0.4 2.6 8.1 0.0 3.9 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CDW54793.1 - 0.0015 17.6 0.2 1.8 7.5 0.0 3.4 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein UspB PF10625.9 CDW54793.1 - 0.076 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Universal stress protein B (UspB) Cytochrom_D1 PF02239.16 CDW54793.1 - 0.17 10.4 0.0 6.7 5.1 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain XPG_I PF00867.18 CDW54794.1 - 8.6e-20 70.9 0.1 3.8e-19 68.8 0.0 2.0 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 CDW54794.1 - 1.6e-07 31.7 0.0 3.6e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 CDW54794.1 - 0.007 15.9 0.2 0.013 15.0 0.2 1.5 1 1 0 1 1 1 1 XPG domain containing TPR_2 PF07719.17 CDW54794.1 - 0.034 14.2 0.0 0.83 9.9 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat MAM PF00629.23 CDW54795.1 - 4.1e-33 114.6 1.9 1e-17 64.5 0.2 3.1 2 1 0 2 2 2 2 MAM domain, meprin/A5/mu Gly_rich PF12810.7 CDW54795.1 - 5.7e-13 49.3 16.7 9.5e-13 48.6 16.7 1.3 1 0 0 1 1 1 1 Glycine rich protein Ldl_recept_a PF00057.18 CDW54795.1 - 0.0018 18.4 9.5 0.0056 16.9 9.5 1.9 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Pkinase_Tyr PF07714.17 CDW54795.1 - 0.011 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase HTH_Tnp_ISL3 PF13542.6 CDW54795.1 - 0.13 11.7 0.0 0.36 10.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Myosin_head PF00063.21 CDW54796.1 - 3.4e-271 901.3 8.9 3.4e-271 901.3 8.9 4.4 2 2 1 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 CDW54796.1 - 1.2e-93 314.8 258.1 1.8e-93 314.2 258.1 1.2 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 CDW54796.1 - 4.3e-13 48.9 0.2 1.2e-12 47.4 0.2 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.21 CDW54796.1 - 0.00012 21.8 23.0 0.00012 21.8 23.0 8.9 1 1 8 9 9 9 5 Intermediate filament protein MbeD_MobD PF04899.12 CDW54796.1 - 0.00045 20.3 1.4 0.00045 20.3 1.4 11.4 8 5 7 15 15 15 2 MbeD/MobD like DUF1664 PF07889.12 CDW54796.1 - 0.00078 19.5 5.3 0.00078 19.5 5.3 13.0 3 1 10 13 13 13 4 Protein of unknown function (DUF1664) ERM PF00769.19 CDW54796.1 - 0.0019 18.1 49.9 0.0019 18.1 49.9 10.0 2 1 7 10 10 10 4 Ezrin/radixin/moesin family AAA_22 PF13401.6 CDW54796.1 - 0.22 11.8 0.1 0.22 11.8 0.1 7.4 3 2 5 8 8 8 0 AAA domain Arrestin_N PF00339.29 CDW54796.1 - 3.7 7.6 7.1 5.7 7.0 0.2 4.2 2 1 1 3 3 3 0 Arrestin (or S-antigen), N-terminal domain RasGEF PF00617.19 CDW54797.1 - 1.4e-39 136.2 1.0 3.3e-39 134.9 0.9 1.7 2 0 0 2 2 2 1 RasGEF domain EF-hand_5 PF13202.6 CDW54797.1 - 8.6e-11 40.8 0.4 9.8e-05 21.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 CDW54797.1 - 3.9e-10 38.5 1.3 1.9e-05 23.9 0.0 2.6 2 0 0 2 2 2 2 EF hand C1_1 PF00130.22 CDW54797.1 - 1.8e-09 37.3 3.2 4e-09 36.2 3.2 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) EF-hand_7 PF13499.6 CDW54797.1 - 2.2e-08 34.4 2.9 0.0015 19.0 0.2 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW54797.1 - 4e-08 32.5 1.1 0.0011 18.7 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CDW54797.1 - 0.001 18.9 0.1 0.083 12.7 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW54797.1 - 0.012 15.9 0.1 0.079 13.3 0.0 2.3 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 CDW54797.1 - 0.02 15.1 0.1 1.6 9.0 0.0 2.7 2 0 0 2 2 2 0 Dockerin type I domain PHD_2 PF13831.6 CDW54797.1 - 0.026 14.1 0.1 0.08 12.5 0.1 1.7 1 0 0 1 1 1 0 PHD-finger PHD PF00628.29 CDW54797.1 - 1.8 8.5 5.7 4.4 7.3 5.7 1.6 1 0 0 1 1 1 0 PHD-finger 5_nucleotid PF05761.14 CDW54798.1 - 8.8e-123 410.6 0.3 1.1e-122 410.3 0.3 1.1 1 0 0 1 1 1 1 5' nucleotidase family Ephrin PF00812.17 CDW54799.1 - 8.7e-36 123.0 0.0 2.2e-35 121.6 0.0 1.6 2 0 0 2 2 2 1 Ephrin Ras PF00071.22 CDW54800.1 - 2.9e-58 196.0 0.5 3.3e-58 195.9 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW54800.1 - 6.2e-21 74.8 0.0 9.5e-21 74.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW54800.1 - 3.2e-09 36.5 0.2 3.5e-09 36.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW54800.1 - 0.00013 21.5 1.1 0.00033 20.3 0.3 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW54800.1 - 0.00015 21.7 2.9 0.038 13.9 0.1 2.2 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDW54800.1 - 0.00028 21.0 0.1 0.00041 20.4 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 CDW54800.1 - 0.014 14.5 0.3 3.2 6.8 0.1 2.1 1 1 0 2 2 2 0 G-protein alpha subunit ParA PF10609.9 CDW54800.1 - 0.083 12.3 0.1 0.61 9.5 0.0 2.0 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase PAP2_C PF14360.6 CDW54801.1 - 1.1e-24 86.7 10.8 1.1e-24 86.7 10.8 2.6 3 0 0 3 3 3 1 PAP2 superfamily C-terminal SAM_1 PF00536.30 CDW54801.1 - 3.2e-11 43.5 0.1 5.7e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW54801.1 - 1.4e-08 34.7 0.1 2.6e-08 33.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 CDW54801.1 - 0.00059 19.8 1.4 0.00098 19.0 0.1 2.0 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 CDW54801.1 - 0.002 17.9 0.1 0.0046 16.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 CDW54801.1 - 0.071 13.4 0.3 0.14 12.4 0.3 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Lipoprotein_3 PF00938.17 CDW54802.1 - 0.074 13.2 0.6 0.15 12.2 0.5 1.6 1 1 0 1 1 1 0 Lipoprotein Nup54 PF13874.6 CDW54802.1 - 0.25 11.5 2.3 12 6.0 0.1 2.8 3 0 0 3 3 3 0 Nucleoporin complex subunit 54 Kinesin PF00225.23 CDW54803.1 - 8.8e-116 386.5 0.1 1.6e-115 385.6 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDW54803.1 - 6.4e-27 94.3 0.3 3.8e-26 91.8 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 CDW54803.1 - 0.002 18.3 4.8 0.002 18.3 4.8 2.2 2 1 0 2 2 2 1 Kinesin-associated Tweety PF04906.13 CDW54803.1 - 0.0061 15.3 0.5 0.074 11.7 0.1 2.3 2 0 0 2 2 2 1 Tweety Fib_alpha PF08702.10 CDW54803.1 - 3.6 7.8 17.6 2.8 8.1 6.3 3.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family EB PF01683.18 CDW54804.1 - 3.5e-16 59.2 96.8 5.8e-08 32.9 15.7 7.0 3 2 4 7 7 7 5 EB module EGF_MSP1_1 PF12946.7 CDW54804.1 - 0.027 14.5 10.5 0.027 14.5 10.5 5.5 5 2 1 6 6 6 0 MSP1 EGF domain 1 Peptidase_M24 PF00557.24 CDW54805.1 - 3.1e-50 170.8 0.4 3.8e-50 170.5 0.4 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 CDW54805.1 - 8.4e-10 38.8 4.6 2.2e-09 37.5 4.6 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding ATP-cone PF03477.16 CDW54805.1 - 0.025 15.1 0.3 3 8.5 0.2 2.3 2 0 0 2 2 2 0 ATP cone domain IR1-M PF12185.8 CDW54805.1 - 0.12 12.3 0.2 0.91 9.5 0.1 2.1 2 0 0 2 2 2 0 Nup358/RanBP2 E3 ligase domain GN3L_Grn1 PF08701.11 CDW54806.1 - 8.3e-17 61.1 19.8 8.3e-17 61.1 19.8 2.3 2 0 0 2 2 2 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 CDW54806.1 - 4.6e-06 26.7 0.3 0.00087 19.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW54806.1 - 5.3e-06 26.1 0.9 0.067 12.7 0.1 2.5 3 0 0 3 3 3 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDW54806.1 - 7.1e-05 22.4 0.5 0.0011 18.6 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW54806.1 - 0.032 14.1 4.7 0.088 12.7 0.0 2.9 4 0 0 4 4 4 0 RsgA GTPase cobW PF02492.19 CDW54806.1 - 0.055 13.0 0.2 0.33 10.5 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 CDW54806.1 - 0.89 9.6 5.4 7.8 6.5 0.0 3.6 3 1 0 3 3 3 0 Dynamin family E1-E2_ATPase PF00122.20 CDW54807.1 - 6.9e-43 146.3 0.2 1.8e-42 144.9 0.2 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDW54807.1 - 6e-42 143.4 1.9 7.6e-42 143.1 0.1 2.1 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CDW54807.1 - 1.6e-21 76.2 0.1 3.1e-21 75.3 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDW54807.1 - 2.6e-21 76.9 0.0 6e-18 65.9 0.0 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDW54807.1 - 1.4e-07 31.6 1.0 0.00017 21.4 0.5 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW54807.1 - 0.008 16.6 0.1 0.17 12.3 0.0 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase PGM1_C PF18105.1 CDW54807.1 - 0.11 12.0 0.3 0.28 10.7 0.3 1.6 1 0 0 1 1 1 0 PGM1 C-terminal domain BppL_N PF18338.1 CDW54807.1 - 5.8 6.9 5.7 4.2 7.3 0.1 3.1 3 0 0 3 3 3 0 Lower baseplate protein N-terminal domain UPF0020 PF01170.18 CDW54808.1 - 5.6e-35 120.8 0.1 3.3e-34 118.3 0.1 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 THUMP PF02926.17 CDW54808.1 - 2.4e-11 43.9 0.0 9.9e-11 41.9 0.0 1.9 2 0 0 2 2 2 1 THUMP domain Methyltransf_25 PF13649.6 CDW54808.1 - 1.6e-08 35.1 0.0 6.1e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain AviRa PF11599.8 CDW54808.1 - 1.3e-06 28.1 0.4 4.3e-05 23.1 0.0 2.1 1 1 1 2 2 2 1 RRNA methyltransferase AviRa Methyltransf_31 PF13847.6 CDW54808.1 - 1.5e-06 28.1 0.0 4.1e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW54808.1 - 5.2e-06 27.0 0.0 1.5e-05 25.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CDW54808.1 - 1.3e-05 24.7 0.0 2.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 CDW54808.1 - 0.00024 20.7 0.0 0.00039 20.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CDW54808.1 - 0.0016 17.8 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 CDW54808.1 - 0.0028 17.3 0.0 0.0044 16.7 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 N6_Mtase PF02384.16 CDW54808.1 - 0.0058 15.9 0.0 0.011 15.1 0.0 1.5 1 1 0 1 1 1 1 N-6 DNA Methylase N6_N4_Mtase PF01555.18 CDW54808.1 - 0.008 15.9 0.0 3.4 7.3 0.0 2.3 2 0 0 2 2 2 2 DNA methylase Methyltransf_15 PF09445.10 CDW54808.1 - 0.026 14.1 0.1 0.062 12.9 0.0 1.6 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase PH PF00169.29 CDW54809.1 - 4.3e-13 49.7 0.0 4.7e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CDW54809.1 - 1.6e-05 25.2 0.4 3.1e-05 24.3 0.4 1.4 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 CDW54809.1 - 0.0009 19.6 0.2 0.0015 18.9 0.2 1.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 CDW54809.1 - 0.0011 18.7 0.0 0.0016 18.3 0.0 1.3 1 1 0 1 1 1 1 Pleckstrin homology domain Hexapep PF00132.24 CDW54810.1 - 0.033 13.9 4.0 0.23 11.3 0.6 3.3 3 2 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) SIS PF01380.22 CDW54811.1 - 1.7e-54 183.2 0.1 8.3e-34 116.3 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CDW54811.1 - 1.2e-14 54.7 0.1 8e-13 48.7 0.1 2.4 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDW54811.1 - 3.5e-13 49.5 0.0 8.4e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 CDW54811.1 - 0.0019 18.3 0.0 0.0063 16.5 0.0 1.9 2 0 0 2 2 2 1 SIS domain GATase_4 PF13230.6 CDW54811.1 - 0.11 11.4 0.9 5.2 5.9 0.1 2.4 2 1 0 3 3 3 0 Glutamine amidotransferases class-II GATase_2 PF00310.21 CDW54811.1 - 0.17 10.5 0.6 0.48 9.1 0.3 1.7 1 1 1 2 2 2 0 Glutamine amidotransferases class-II RTC PF01137.21 CDW54813.1 - 3.2e-52 176.9 0.0 4.5e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Torsin PF06309.11 CDW54813.1 - 1.7e-46 157.4 0.2 3.6e-46 156.4 0.2 1.6 1 0 0 1 1 1 1 Torsin RTC_insert PF05189.13 CDW54813.1 - 1.4e-26 93.0 0.0 2.7e-26 92.1 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain APG12 PF04110.13 CDW54813.1 - 4.8e-10 39.7 0.0 1e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 RNase_H2_suC PF08615.11 CDW54813.1 - 9e-10 38.9 0.1 1.3e-07 31.8 0.0 2.3 1 1 1 2 2 2 2 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) SPT_ssu-like PF11779.8 CDW54813.1 - 2.7e-07 30.1 3.3 7.3e-07 28.7 3.3 1.8 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like LRR_8 PF13855.6 CDW54814.1 - 6e-55 182.9 46.8 3.8e-16 58.6 5.8 5.1 3 1 2 5 5 5 5 Leucine rich repeat I-set PF07679.16 CDW54814.1 - 5.7e-37 125.7 0.0 1.5e-16 60.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54814.1 - 4.6e-32 110.5 0.0 4.4e-13 49.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain LRR_4 PF12799.7 CDW54814.1 - 2.3e-24 85.0 34.6 1e-05 25.8 1.7 6.6 4 1 2 7 7 7 7 Leucine Rich repeats (2 copies) Ig_2 PF13895.6 CDW54814.1 - 3.4e-23 81.8 0.0 9.6e-08 32.3 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain LRR_5 PF13306.6 CDW54814.1 - 6.5e-20 71.4 0.0 1.2e-07 31.7 0.0 3.3 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) ig PF00047.25 CDW54814.1 - 1.7e-18 66.5 0.0 1.2e-08 35.0 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain LRR_9 PF14580.6 CDW54814.1 - 3e-13 49.7 12.4 1.7e-06 27.7 1.4 4.1 2 2 2 4 4 4 4 Leucine-rich repeat V-set PF07686.17 CDW54814.1 - 1.2e-12 48.0 2.0 3.9e-07 30.2 0.1 4.9 3 2 1 4 4 4 2 Immunoglobulin V-set domain LRR_1 PF00560.33 CDW54814.1 - 7.9e-09 34.9 23.8 1.9 9.4 0.1 9.0 8 1 0 8 8 8 3 Leucine Rich Repeat Ig_6 PF18452.1 CDW54814.1 - 4.4e-06 26.2 0.0 0.87 9.2 0.0 3.7 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 CDW54814.1 - 0.0052 16.8 0.1 0.23 11.6 0.0 2.8 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 CDW54814.1 - 0.011 15.7 0.0 4 7.6 0.0 3.7 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Herpes_gE PF02480.16 CDW54814.1 - 0.018 13.8 4.0 5.7 5.6 0.0 3.8 2 1 1 4 4 4 0 Alphaherpesvirus glycoprotein E LRR_6 PF13516.6 CDW54814.1 - 0.17 12.1 33.9 0.38 10.9 0.1 8.0 9 0 0 9 9 8 0 Leucine Rich repeat Ig_3 PF13927.6 CDW54815.1 - 6.5e-12 45.9 0.0 3.2e-11 43.6 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin domain ZU5 PF00791.20 CDW54815.1 - 6.8e-11 42.4 0.0 1.4e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 ZU5 domain I-set PF07679.16 CDW54815.1 - 7.4e-10 38.8 0.0 2e-09 37.4 0.0 1.8 2 0 0 2 2 2 1 Immunoglobulin I-set domain Death PF00531.22 CDW54815.1 - 1.4e-09 38.0 0.2 2.8e-09 37.0 0.2 1.6 1 0 0 1 1 1 1 Death domain ig PF00047.25 CDW54815.1 - 5.5e-07 29.7 0.0 1.4e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain UPA PF17217.3 CDW54815.1 - 2.3e-06 27.6 0.0 6.8e-06 26.0 0.0 1.7 2 0 0 2 2 2 1 UPA domain Ig_2 PF13895.6 CDW54815.1 - 3e-06 27.5 0.0 1e-05 25.8 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 CDW54815.1 - 0.00017 21.7 0.1 0.0063 16.7 0.0 3.1 2 1 0 2 2 2 1 Immunoglobulin V-set domain TSP_1 PF00090.19 CDW54815.1 - 0.00069 19.8 13.7 0.00069 19.8 13.7 3.8 3 1 0 3 3 3 1 Thrombospondin type 1 domain Ig_6 PF18452.1 CDW54815.1 - 0.0073 15.9 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain CCDC66 PF15236.6 CDW54817.1 - 0.0034 17.2 34.1 0.011 15.6 34.1 1.9 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 66 GvpH PF05455.11 CDW54817.1 - 0.12 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 GvpH DUF2947 PF11163.8 CDW54817.1 - 0.18 11.6 0.0 0.18 11.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2947) Asp-B-Hydro_N PF05279.11 CDW54817.1 - 7.5 6.5 13.5 15 5.5 13.5 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SH3_1 PF00018.28 CDW54818.1 - 9.2e-57 188.5 1.4 1e-12 47.4 0.0 6.3 6 0 0 6 6 6 6 SH3 domain SH3_9 PF14604.6 CDW54818.1 - 2.7e-52 174.4 3.9 1.8e-09 37.3 0.0 6.4 6 0 0 6 6 6 6 Variant SH3 domain SH3_2 PF07653.17 CDW54818.1 - 2.8e-39 132.6 0.4 8.1e-07 28.6 0.0 6.4 6 0 0 6 6 6 6 Variant SH3 domain RhoGEF PF00621.20 CDW54818.1 - 1e-15 58.5 1.7 2.6e-15 57.2 1.7 1.7 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.18 CDW54818.1 - 3.4e-11 43.2 1.2 3.4e-11 43.2 1.2 2.3 2 1 0 2 2 2 1 BAR domain SH3_3 PF08239.11 CDW54818.1 - 0.036 14.3 0.2 10 6.5 0.1 2.8 2 0 0 2 2 2 0 Bacterial SH3 domain Tmemb_18A PF09771.9 CDW54819.1 - 5.1e-41 139.8 0.1 6e-41 139.6 0.1 1.1 1 0 0 1 1 1 1 Transmembrane protein 188 Pkinase PF00069.25 CDW54820.1 - 6.2e-69 232.3 0.0 1.1e-68 231.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54820.1 - 2.1e-47 161.6 0.1 3.2e-47 161.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CDW54820.1 - 2.7e-17 62.9 0.0 1e-16 61.0 0.0 2.1 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 CDW54820.1 - 7.3e-08 31.6 0.0 1.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDW54820.1 - 1.8e-05 24.2 0.0 3.9e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CDW54820.1 - 0.0025 16.8 0.6 0.0042 16.1 0.6 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CDW54820.1 - 0.012 15.2 1.1 5.3 6.6 0.0 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CDW54820.1 - 0.049 13.6 0.1 0.15 11.9 0.1 1.8 1 1 0 1 1 1 0 Phosphotransferase enzyme family I-set PF07679.16 CDW54821.1 - 1.6e-46 156.2 0.0 1.4e-09 37.9 0.0 6.6 6 0 0 6 6 6 5 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54821.1 - 1.3e-44 150.7 0.0 3.2e-09 37.3 0.0 7.0 6 0 0 6 6 6 4 Immunoglobulin domain fn3 PF00041.21 CDW54821.1 - 3.4e-32 110.6 14.9 1e-10 41.8 2.8 5.7 5 0 0 5 5 5 4 Fibronectin type III domain Ig_2 PF13895.6 CDW54821.1 - 2.2e-28 98.4 0.0 4.7e-06 26.8 0.0 6.4 6 0 0 6 6 6 4 Immunoglobulin domain ig PF00047.25 CDW54821.1 - 4.9e-23 81.1 0.0 0.00022 21.4 0.0 6.2 6 0 0 6 6 6 4 Immunoglobulin domain Bravo_FIGEY PF13882.6 CDW54821.1 - 3.6e-20 73.1 1.8 7.6e-20 72.1 1.8 1.6 1 0 0 1 1 1 1 Bravo-like intracellular region V-set PF07686.17 CDW54821.1 - 1.1e-12 48.0 1.3 0.0077 16.4 0.0 8.4 8 1 0 8 8 8 2 Immunoglobulin V-set domain Pur_ac_phosph_N PF16656.5 CDW54821.1 - 0.0012 19.3 1.3 0.14 12.7 0.2 3.8 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 CDW54821.1 - 0.0015 18.6 0.0 0.28 11.3 0.0 3.6 4 0 0 4 4 3 1 CD80-like C2-set immunoglobulin domain DUF2207 PF09972.9 CDW54821.1 - 0.0034 16.2 0.0 0.0058 15.4 0.0 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Y_Y_Y PF07495.13 CDW54821.1 - 0.054 13.4 0.3 6.7 6.7 0.2 3.1 3 0 0 3 3 3 0 Y_Y_Y domain DUF5531 PF17671.1 CDW54821.1 - 0.12 12.2 0.0 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5531) Big_3_4 PF13754.6 CDW54821.1 - 0.13 12.1 0.0 0.32 10.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Metallophos PF00149.28 CDW54822.1 - 3.1e-35 122.6 0.0 5e-35 121.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 CDW54822.1 - 0.04 13.3 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5378) PPP5 PF08321.12 CDW54822.1 - 0.084 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 PPP5 TPR repeat region Kelch_4 PF13418.6 CDW54823.1 - 3.5e-24 84.6 14.1 1.9e-06 27.8 0.1 7.1 6 2 3 9 9 9 5 Galactose oxidase, central domain Kelch_5 PF13854.6 CDW54823.1 - 9.2e-19 67.0 0.4 0.0027 17.7 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 CDW54823.1 - 2.6e-16 58.9 3.6 2e-06 27.3 0.0 6.0 6 0 0 6 6 6 3 Kelch motif Cytochrom_B561 PF03188.16 CDW54823.1 - 2.1e-15 57.1 7.8 4e-15 56.2 7.8 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Kelch_3 PF13415.6 CDW54823.1 - 2.1e-14 53.4 3.1 0.00061 20.0 0.0 4.9 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 CDW54823.1 - 1.7e-10 40.8 3.6 0.15 12.4 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 CDW54823.1 - 6.1e-05 22.8 10.3 0.023 14.6 0.1 6.3 7 0 0 7 7 7 1 Kelch motif DUF4079 PF13301.6 CDW54823.1 - 0.00065 19.9 6.5 0.0021 18.2 6.5 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF4079) DUF2231 PF09990.9 CDW54823.1 - 0.0015 19.0 3.8 0.0046 17.4 3.8 1.8 1 0 0 1 1 1 1 Predicted membrane protein (DUF2231) PDZ_2 PF13180.6 CDW54823.1 - 0.0046 17.3 0.1 0.009 16.3 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW54823.1 - 0.012 15.9 0.1 0.021 15.2 0.1 1.4 1 0 0 1 1 1 0 PDZ domain DctP PF03480.13 CDW54823.1 - 0.014 14.8 0.2 0.023 14.0 0.2 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 Pox_A14 PF05767.12 CDW54823.1 - 0.045 13.9 0.6 0.14 12.4 0.6 1.8 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF2427 PF10348.9 CDW54823.1 - 0.11 12.3 9.6 0.1 12.4 1.7 3.3 2 2 0 2 2 2 0 Domain of unknown function (DUF2427) IF-2B PF01008.17 CDW54824.1 - 9e-22 77.6 0.3 5.2e-21 75.1 0.0 1.8 1 1 1 2 2 2 1 Initiation factor 2 subunit family KH_1 PF00013.29 CDW54825.1 - 5.8e-18 64.5 0.0 2e-12 46.7 0.0 3.2 3 0 0 3 3 3 2 KH domain SAM_1 PF00536.30 CDW54825.1 - 2.4e-05 24.7 0.0 4.4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_10 PF17905.1 CDW54825.1 - 0.0006 20.2 0.2 1.7 9.1 0.2 3.4 2 1 0 2 2 2 2 GLD-3 KH domain 5 SAM_2 PF07647.17 CDW54825.1 - 0.0023 18.0 0.0 0.0063 16.6 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Baculo_helicase PF04735.12 CDW54825.1 - 0.054 11.0 0.3 0.17 9.4 0.2 1.6 2 0 0 2 2 2 0 Baculovirus DNA helicase zf-CCCH PF00642.24 CDW54826.1 - 2.6e-12 46.3 16.3 5.5e-07 29.3 2.5 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CDW54826.1 - 1e-05 26.2 3.7 0.018 15.7 0.2 2.4 2 0 0 2 2 2 2 Torus domain RRM_1 PF00076.22 CDW54826.1 - 1.4e-05 24.8 0.0 2.4e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CDW54826.1 - 0.00046 20.1 16.2 0.01 15.8 3.1 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_3 PF15663.5 CDW54826.1 - 0.015 15.5 2.4 0.9 9.8 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger containing family Nup35_RRM_2 PF14605.6 CDW54826.1 - 0.079 13.0 0.1 0.24 11.4 0.1 1.8 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ccdc124 PF06244.12 CDW54827.1 - 6.7e-31 107.5 30.8 2.8e-28 99.0 30.8 2.6 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 CDW54827.1 - 5.6e-06 26.7 0.4 5.6e-06 26.7 0.4 2.8 2 1 0 3 3 3 1 HMG (high mobility group) box Octopine_DH PF02317.17 CDW54827.1 - 0.25 11.4 2.6 6.5 6.8 0.0 2.1 1 1 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain DUF2828 PF11443.8 CDW54827.1 - 1.6 6.7 12.1 0.72 7.9 9.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Spore_III_AF PF09581.10 CDW54827.1 - 6.7 6.7 11.4 10 6.1 11.4 1.4 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) zf-FCS PF06467.14 CDW54828.1 - 0.028 14.3 5.7 0.49 10.4 1.1 2.5 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_jaz PF12171.8 CDW54828.1 - 0.038 14.3 0.5 0.038 14.3 0.5 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CDW54828.1 - 0.19 12.2 7.8 1.4 9.5 0.2 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW54828.1 - 0.39 11.7 10.0 1.5 9.8 0.2 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger PyrI_C PF02748.15 CDW54828.1 - 0.95 9.4 5.4 5.3 7.0 0.2 2.4 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Pkinase PF00069.25 CDW54829.1 - 1.5e-97 326.1 1.0 9.6e-27 94.0 0.1 4.1 4 0 0 4 4 4 4 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54829.1 - 3.7e-48 164.1 0.0 2.9e-14 53.0 0.0 4.1 4 0 0 4 4 4 4 Protein tyrosine kinase Kdo PF06293.14 CDW54829.1 - 4.1e-16 59.0 0.0 0.0035 16.7 0.0 4.2 4 0 0 4 4 4 4 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW54829.1 - 9.2e-15 54.3 0.1 0.0033 16.2 0.0 4.2 4 0 0 4 4 4 4 Fungal protein kinase APH PF01636.23 CDW54829.1 - 7.7e-11 42.4 0.0 0.0017 18.3 0.0 4.5 4 0 0 4 4 4 3 Phosphotransferase enzyme family FTA2 PF13095.6 CDW54829.1 - 3.3e-05 23.6 0.0 2.3 7.8 0.0 4.3 4 0 0 4 4 4 1 Kinetochore Sim4 complex subunit FTA2 Defensin_beta_2 PF13841.6 CDW54829.1 - 0.0023 18.4 1.0 0.078 13.5 0.2 3.0 2 0 0 2 2 2 1 Beta defensin Kinase-like PF14531.6 CDW54829.1 - 0.15 11.4 0.0 14 4.9 0.0 3.3 4 0 0 4 4 4 0 Kinase-like LRR_8 PF13855.6 CDW54831.1 - 1.2e-44 149.9 42.0 4.7e-13 48.7 4.0 7.6 2 1 6 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 CDW54831.1 - 8e-23 80.1 46.4 6.7e-05 23.2 0.9 9.4 6 2 5 11 11 10 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW54831.1 - 1.4e-17 63.9 0.0 3.2e-07 30.4 0.0 3.1 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) Ig_3 PF13927.6 CDW54831.1 - 3.8e-12 46.6 0.3 1.2e-11 45.0 0.1 2.0 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 CDW54831.1 - 1.7e-11 44.0 0.0 4.1e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_9 PF14580.6 CDW54831.1 - 4.2e-11 42.7 11.7 0.00046 19.7 1.8 4.3 1 1 3 4 4 4 4 Leucine-rich repeat ig PF00047.25 CDW54831.1 - 4.5e-10 39.6 0.2 2.1e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain LRR_1 PF00560.33 CDW54831.1 - 2.6e-07 30.2 37.6 0.085 13.5 1.1 10.7 12 0 0 12 12 10 3 Leucine Rich Repeat fn3 PF00041.21 CDW54831.1 - 2e-06 28.1 0.0 5.1e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain Ig_2 PF13895.6 CDW54831.1 - 7.5e-06 26.2 0.1 1.8e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRRNT PF01462.18 CDW54831.1 - 0.00011 21.7 1.5 0.00011 21.7 1.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain V-set PF07686.17 CDW54831.1 - 0.00054 20.1 0.1 0.002 18.3 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin V-set domain DUF2207 PF09972.9 CDW54831.1 - 0.0021 16.9 0.0 0.003 16.4 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Pur_ac_phosph_N PF16656.5 CDW54831.1 - 0.017 15.7 0.2 0.057 14.0 0.1 2.0 2 0 0 2 2 1 0 Purple acid Phosphatase, N-terminal domain HHH_6 PF14579.6 CDW54831.1 - 0.03 14.6 0.2 0.44 10.8 0.1 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif Adeno_E3_CR1 PF02440.15 CDW54831.1 - 0.14 12.0 0.1 0.34 10.7 0.1 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 Ig_4 PF16680.5 CDW54831.1 - 0.17 12.2 0.0 0.39 11.0 0.0 1.5 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 CDW54831.1 - 0.19 11.8 0.1 0.56 10.3 0.0 1.8 2 0 0 2 2 1 0 Izumo-like Immunoglobulin domain UPRTase PF14681.6 CDW54832.1 - 3.2e-69 232.5 0.0 4.7e-69 232.0 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 CDW54832.1 - 5e-52 176.5 0.0 7.4e-52 176.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.6 CDW54832.1 - 2.3e-05 24.9 0.6 0.0044 17.5 0.3 3.1 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDW54832.1 - 3e-05 24.6 0.0 6.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 CDW54832.1 - 5.4e-05 23.1 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein CoaE PF01121.20 CDW54832.1 - 0.0016 18.2 1.4 0.026 14.2 1.4 2.2 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 CDW54832.1 - 0.002 18.3 0.0 0.0041 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CDW54832.1 - 0.0033 17.2 0.0 0.9 9.2 0.0 2.2 2 0 0 2 2 2 2 Cytidylate kinase Zeta_toxin PF06414.12 CDW54832.1 - 0.0068 15.7 0.0 0.015 14.6 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.6 CDW54832.1 - 0.18 12.0 0.0 0.46 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain Lectin_leg-like PF03388.13 CDW54833.1 - 2.5e-62 210.2 0.0 3.4e-62 209.8 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 CDW54833.1 - 1.6e-05 25.0 0.0 2.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 CDW54833.1 - 0.0018 17.9 0.0 0.0083 15.7 0.0 2.1 1 1 1 2 2 2 1 Legume lectin domain ATP-synt_E PF05680.12 CDW54833.1 - 0.046 14.0 1.7 0.088 13.2 1.7 1.4 1 0 0 1 1 1 0 ATP synthase E chain Astro_capsid_p PF12226.8 CDW54833.1 - 0.047 12.8 0.1 0.064 12.4 0.1 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Spem1 PF15670.5 CDW54833.1 - 0.11 12.1 0.2 0.16 11.5 0.2 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 Abhydrolase_1 PF00561.20 CDW54834.1 - 1.5e-12 47.7 0.0 3.4e-06 26.9 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDW54834.1 - 5.4e-08 32.4 0.0 0.0012 18.2 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDW54834.1 - 1.6e-06 28.9 0.0 9.3e-05 23.1 0.0 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF818 PF05677.12 CDW54834.1 - 0.0008 18.5 0.0 0.0012 17.9 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Peptidase_S9 PF00326.21 CDW54834.1 - 0.0099 15.4 0.0 0.11 12.0 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF1057 PF06342.12 CDW54834.1 - 0.028 13.4 0.0 0.04 12.9 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Asp2 PF16929.5 CDW54834.1 - 0.076 12.0 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter SAYSvFN PF10260.9 CDW54835.1 - 1.5e-22 79.3 0.1 2.2e-22 78.7 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) Wbp11 PF09429.10 CDW54837.1 - 6.1e-20 71.4 1.8 1.1e-19 70.6 1.8 1.4 1 0 0 1 1 1 1 WW domain binding protein 11 zf-C2HC PF01530.18 CDW54838.1 - 9.8e-54 179.2 54.4 6.8e-15 55.0 6.6 4.8 4 0 0 4 4 4 4 Zinc finger, C2HC type zf-RAG1 PF10426.9 CDW54838.1 - 0.018 15.2 5.7 16 5.8 0.0 4.7 5 0 0 5 5 5 0 Recombination-activating protein 1 zinc-finger domain Cwf_Cwc_15 PF04889.12 CDW54838.1 - 3.5 7.3 17.8 0.49 10.1 10.8 2.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Syntaxin_2 PF14523.6 CDW54839.1 - 0.0076 16.6 0.8 0.016 15.6 0.1 2.0 2 1 0 2 2 2 1 Syntaxin-like protein KH_1 PF00013.29 CDW54841.1 - 8.7e-41 137.6 2.9 2.1e-14 53.1 0.4 4.1 3 1 0 3 3 3 3 KH domain KH_2 PF07650.17 CDW54841.1 - 2.1e-16 59.5 0.3 0.00014 21.6 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 CDW54841.1 - 3.7e-06 26.9 1.3 0.32 11.1 0.2 3.4 3 0 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 CDW54841.1 - 3.9e-06 26.6 1.6 0.58 10.1 0.1 3.3 3 0 0 3 3 3 3 KH domain Apt1 PF10351.9 CDW54842.1 - 4.8e-71 240.0 7.5 7.5e-70 236.1 7.5 2.6 1 1 0 1 1 1 1 Golgi-body localisation protein domain Zip PF02535.22 CDW54842.1 - 7.4e-48 163.5 15.5 1.1e-47 162.9 15.5 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Fmp27_GFWDK PF10347.9 CDW54842.1 - 5.5e-17 62.3 0.0 3.8e-16 59.6 0.0 2.4 1 1 1 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 CDW54842.1 - 0.032 14.2 0.0 0.16 11.9 0.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF2405) Ank_5 PF13857.6 CDW54843.1 - 2e-30 104.4 5.7 4.4e-09 36.4 0.2 4.5 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW54843.1 - 4.4e-29 100.9 0.2 9.2e-14 51.8 0.3 2.6 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW54843.1 - 8.4e-27 93.2 3.1 7e-05 23.3 0.0 5.9 4 2 2 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 CDW54843.1 - 6.2e-26 89.7 5.4 6.9e-05 23.1 0.1 6.1 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 CDW54843.1 - 5.2e-21 72.5 4.5 0.00024 21.3 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeat ADH_zinc_N PF00107.26 CDW54844.1 - 3.1e-16 59.6 0.0 5.4e-16 58.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW54844.1 - 2.8e-05 23.9 0.0 6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CDW54844.1 - 4.3e-05 24.6 0.0 7.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Ran_BP1 PF00638.18 CDW54845.1 - 0.00015 22.0 0.0 0.00022 21.5 0.0 1.2 1 0 0 1 1 1 1 RanBP1 domain PFK PF00365.20 CDW54846.1 - 1.3e-189 628.5 4.2 4.6e-103 344.4 0.4 2.0 2 0 0 2 2 2 2 Phosphofructokinase DUF4061 PF13270.6 CDW54847.1 - 6.4e-10 39.2 3.0 1.6e-09 37.9 3.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) DUF2913 PF11140.8 CDW54847.1 - 0.024 14.4 0.7 0.038 13.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2913) DUF334 PF03904.13 CDW54847.1 - 0.072 12.6 1.9 0.12 11.9 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF334) FapA PF03961.13 CDW54847.1 - 0.31 9.6 1.0 0.34 9.5 1.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Arm PF00514.23 CDW54848.1 - 0.0016 18.4 0.0 0.083 13.0 0.0 3.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat GIT1_C PF12205.8 CDW54848.1 - 0.12 12.5 0.7 1.5 9.0 0.0 2.6 2 1 1 3 3 3 0 G protein-coupled receptor kinase-interacting protein 1 C term Atx10homo_assoc PF09759.9 CDW54848.1 - 0.19 11.8 2.6 1.4 9.0 0.1 2.7 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain PAS_3 PF08447.12 CDW54849.1 - 1.6e-05 25.1 0.0 7.1e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 CDW54849.1 - 0.00027 21.0 0.0 0.00072 19.7 0.0 1.7 1 0 0 1 1 1 1 PAS domain RINGv PF12906.7 CDW54850.1 - 1.5e-13 50.6 6.1 3.7e-13 49.4 6.1 1.7 1 0 0 1 1 1 1 RING-variant domain Neur_chan_LBD PF02931.23 CDW54851.1 - 2.7e-50 170.8 10.0 4.5e-50 170.1 10.0 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW54851.1 - 4.8e-22 79.2 0.7 6.7e-22 78.7 0.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Lipase PF00151.19 CDW54852.1 - 1.1e-69 235.4 0.0 1.8e-69 234.6 0.0 1.4 2 0 0 2 2 2 1 Lipase Abhydrolase_2 PF02230.16 CDW54852.1 - 0.00062 19.6 0.1 0.0023 17.8 0.0 1.8 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 CDW54852.1 - 0.0012 19.5 0.0 0.0015 19.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 CDW54852.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Kelch_4 PF13418.6 CDW54852.1 - 0.22 11.6 1.0 1.5 8.9 0.1 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain KleE PF17394.2 CDW54854.1 - 0.065 13.4 2.3 0.13 12.5 2.3 1.5 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein PRT_C PF08372.10 CDW54854.1 - 0.23 11.2 6.7 1.5 8.6 0.2 2.3 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal dCache_1 PF02743.18 CDW54855.1 - 3.5e-12 46.6 0.0 1.2e-07 31.7 0.0 2.4 2 0 0 2 2 2 2 Cache domain VWA_N PF08399.11 CDW54855.1 - 0.019 15.5 0.0 0.057 13.9 0.0 1.8 1 0 0 1 1 1 0 VWA N-terminal Sec23_helical PF04815.15 CDW54855.1 - 0.06 13.2 0.1 1.2 9.0 0.1 2.6 2 0 0 2 2 2 0 Sec23/Sec24 helical domain I-set PF07679.16 CDW54856.1 - 0 991.7 20.5 3e-21 75.3 0.0 20.1 19 1 0 19 19 19 18 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54856.1 - 2.9e-211 684.7 20.4 3e-16 59.8 0.1 18.8 18 0 0 18 18 18 18 Immunoglobulin domain Ig_2 PF13895.6 CDW54856.1 - 2.9e-122 399.2 41.0 3.2e-09 37.0 0.1 18.5 18 0 0 18 18 18 17 Immunoglobulin domain ig PF00047.25 CDW54856.1 - 1.1e-98 323.6 42.7 2.2e-08 34.2 0.1 18.8 18 0 0 18 18 18 17 Immunoglobulin domain Pkinase_Tyr PF07714.17 CDW54856.1 - 4.2e-77 258.9 0.0 9e-77 257.8 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase fn3 PF00041.21 CDW54856.1 - 1.2e-66 221.1 18.0 8.6e-16 58.1 0.2 7.0 6 0 0 6 6 6 6 Fibronectin type III domain V-set PF07686.17 CDW54856.1 - 1.1e-41 141.4 50.6 0.0019 18.4 0.0 24.0 17 11 0 17 17 17 9 Immunoglobulin V-set domain Pkinase PF00069.25 CDW54856.1 - 1.6e-32 113.0 0.0 7.6e-32 110.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW54856.1 - 5.3e-24 84.1 0.4 1.2e-22 79.7 0.0 3.1 2 0 0 2 2 2 1 SH2 domain C2-set_2 PF08205.12 CDW54856.1 - 2.7e-23 81.8 20.2 0.11 12.5 0.0 15.6 15 0 0 15 15 15 3 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 CDW54856.1 - 6.7e-19 67.2 9.1 0.022 14.3 0.0 11.2 12 0 0 12 12 12 4 Immunoglobulin domain Ig_5 PF16681.5 CDW54856.1 - 5.2e-16 58.8 14.1 0.044 14.2 0.0 13.1 14 0 0 14 14 12 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Receptor_2B4 PF11465.8 CDW54856.1 - 2.6e-14 53.3 2.5 1.2 9.3 0.0 11.5 13 0 0 13 13 12 2 Natural killer cell receptor 2B4 SH3_1 PF00018.28 CDW54856.1 - 1.8e-13 49.8 0.1 4.5e-13 48.6 0.1 1.7 1 0 0 1 1 1 1 SH3 domain Ig_4 PF16680.5 CDW54856.1 - 2.5e-09 37.2 19.9 2.7 8.3 0.0 12.7 14 0 0 14 14 12 1 T-cell surface glycoprotein CD3 delta chain SH3_9 PF14604.6 CDW54856.1 - 1.2e-08 34.7 0.8 3e-08 33.4 0.2 2.1 2 0 0 2 2 1 1 Variant SH3 domain Izumo-Ig PF16706.5 CDW54856.1 - 1.1e-07 31.8 27.6 8 6.6 0.0 12.9 17 0 0 17 17 13 0 Izumo-like Immunoglobulin domain Pur_ac_phosph_N PF16656.5 CDW54856.1 - 3e-06 27.7 12.8 0.27 11.8 0.1 6.6 4 1 0 4 4 4 2 Purple acid Phosphatase, N-terminal domain Adeno_E3_CR1 PF02440.15 CDW54856.1 - 0.00032 20.4 10.6 0.36 10.6 0.1 6.4 7 0 0 7 7 6 2 Adenovirus E3 region protein CR1 Interfer-bind PF09294.10 CDW54856.1 - 0.003 17.9 3.0 2.2 8.6 0.1 5.1 5 0 0 5 5 4 1 Interferon-alpha/beta receptor, fibronectin type III CBM_15 PF03426.14 CDW54856.1 - 0.007 16.0 0.3 2.7 7.6 0.0 3.8 3 0 0 3 3 3 1 Carbohydrate binding domain (family 15) Egh16-like PF11327.8 CDW54856.1 - 0.0096 16.4 0.0 0.046 14.1 0.0 2.2 1 0 0 1 1 1 1 Egh16-like virulence factor V-set_CD47 PF08204.11 CDW54856.1 - 0.015 15.3 3.2 18 5.3 0.0 6.3 7 0 0 7 7 6 0 CD47 immunoglobulin-like domain DUF2369 PF10179.9 CDW54856.1 - 0.021 15.2 0.1 4.4 7.8 0.0 3.9 4 0 0 4 4 2 0 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 CDW54856.1 - 0.049 13.8 1.8 62 3.8 0.0 4.4 4 0 0 4 4 4 0 Fibronectin type III domain SH3_3 PF08239.11 CDW54856.1 - 0.079 13.3 0.0 0.3 11.4 0.0 2.1 1 0 0 1 1 1 0 Bacterial SH3 domain CDC48_2 PF02933.17 CDW54856.1 - 0.081 12.7 0.1 0.42 10.4 0.0 2.4 2 0 0 2 2 1 0 Cell division protein 48 (CDC48), domain 2 DUF2914 PF11141.8 CDW54856.1 - 0.095 12.5 5.9 11 5.8 0.0 5.3 5 0 0 5 5 4 0 Protein of unknown function (DUF2914) C2-set PF05790.15 CDW54856.1 - 0.1 12.8 2.9 2.3 8.5 0.1 4.5 5 0 0 5 5 3 0 Immunoglobulin C2-set domain hSH3 PF14603.6 CDW54856.1 - 0.12 12.8 0.0 0.4 11.1 0.0 1.9 1 0 0 1 1 1 0 Helically-extended SH3 domain DUF3952 PF13130.6 CDW54856.1 - 4.7 7.5 5.2 1.3e+02 2.8 0.0 5.0 6 0 0 6 6 5 0 Domain of unknown function (DUF3952) I-set PF07679.16 CDW54857.1 - 9.7e-22 76.9 0.0 3e-21 75.3 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54857.1 - 6e-16 58.8 0.0 2.2e-15 57.0 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 CDW54857.1 - 1.1e-10 41.6 0.1 3.6e-09 36.7 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 CDW54857.1 - 1.1e-10 41.7 0.1 4.5e-09 36.5 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 CDW54857.1 - 0.00082 19.5 0.2 0.34 11.1 0.1 3.2 2 1 0 2 2 2 1 Immunoglobulin V-set domain DUF281 PF03436.13 CDW54857.1 - 0.18 12.2 0.5 1.5 9.3 0.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF281) I-set PF07679.16 CDW54858.1 - 0 1183.6 0.0 3.5e-16 59.0 0.0 28.0 28 1 0 28 28 28 27 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54858.1 - 1.7e-257 832.8 0.0 2.2e-11 44.2 0.1 28.4 28 0 0 28 28 28 27 Immunoglobulin domain Ig_2 PF13895.6 CDW54858.1 - 4.6e-161 523.6 19.2 5.4e-10 39.5 0.0 26.0 26 0 0 26 26 25 24 Immunoglobulin domain ig PF00047.25 CDW54858.1 - 3.3e-157 511.1 1.9 5e-10 39.4 0.0 25.8 26 0 0 26 26 25 21 Immunoglobulin domain V-set PF07686.17 CDW54858.1 - 9.8e-77 254.2 50.9 0.00046 20.3 0.2 34.5 25 14 1 26 26 25 17 Immunoglobulin V-set domain C1-set PF07654.15 CDW54858.1 - 1.7e-46 156.5 18.6 0.015 15.7 0.0 22.8 24 0 0 24 24 22 10 Immunoglobulin C1-set domain Ig_6 PF18452.1 CDW54858.1 - 3.3e-32 109.8 34.3 0.0015 18.1 0.1 19.8 21 0 0 21 21 21 7 Immunoglobulin domain BiPBP_C PF06832.12 CDW54858.1 - 4.1e-32 110.1 0.0 0.73 9.9 0.0 20.1 22 1 0 22 22 20 7 Penicillin-Binding Protein C-terminus Family Titin_Ig-rpts PF06582.12 CDW54858.1 - 4.3e-31 106.5 63.0 3e-06 27.1 0.4 14.4 16 0 0 16 16 15 9 Titin repeat V-set_CD47 PF08204.11 CDW54858.1 - 6.9e-23 81.1 2.3 0.25 11.3 0.0 16.0 15 4 0 15 15 15 4 CD47 immunoglobulin-like domain C2-set_2 PF08205.12 CDW54858.1 - 1.9e-16 59.9 1.9 3.6 7.7 0.0 15.6 19 0 0 19 19 16 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 CDW54858.1 - 3.3e-16 59.3 5.2 20 5.5 0.1 16.6 18 0 0 18 18 18 0 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 CDW54858.1 - 4.3e-15 55.9 0.0 0.07 13.3 0.0 13.9 18 0 0 18 18 15 1 Natural killer cell receptor 2B4 Ig_5 PF16681.5 CDW54858.1 - 1.8e-11 44.3 15.5 0.72 10.3 0.1 15.7 18 0 0 18 18 17 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain PKD PF00801.20 CDW54858.1 - 1.6e-06 27.9 0.7 9 6.2 0.0 6.4 5 0 0 5 5 5 0 PKD domain Big_2 PF02368.18 CDW54858.1 - 8.2e-05 22.4 0.3 10 6.1 0.1 5.8 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 2) Herpes_gE PF02480.16 CDW54858.1 - 9.6e-05 21.3 0.0 16 4.1 0.0 7.0 10 0 0 10 10 10 0 Alphaherpesvirus glycoprotein E PKD_3 PF16820.5 CDW54858.1 - 0.00087 19.0 0.2 17 5.3 0.1 5.7 6 0 0 6 6 5 0 PKD-like domain UL141 PF16758.5 CDW54858.1 - 0.0022 17.7 7.4 1.1 9.0 0.0 7.2 9 0 0 9 9 8 1 Herpes-like virus membrane glycoprotein UL141 C2-set PF05790.15 CDW54858.1 - 0.0041 17.3 22.4 3.4 7.9 0.0 11.8 14 0 0 14 14 12 1 Immunoglobulin C2-set domain DUF4032 PF13224.6 CDW54858.1 - 0.078 12.8 0.0 2.8 7.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4032) EKR PF10371.9 CDW54858.1 - 0.12 12.2 0.1 4.7 7.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function ASH PF15780.5 CDW54858.1 - 1.2 9.4 7.2 13 6.1 0.0 5.6 5 0 0 5 5 4 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin I-set PF07679.16 CDW54859.1 - 3.1e-71 235.5 0.0 1.1e-22 79.8 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54859.1 - 4.3e-49 165.0 1.1 5.6e-15 55.7 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 CDW54859.1 - 2.4e-33 114.3 0.4 9.1e-10 38.7 0.1 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 CDW54859.1 - 2.5e-28 98.1 0.3 5.3e-11 42.5 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 CDW54859.1 - 5.5e-16 58.7 3.2 0.0001 22.4 0.0 6.1 3 3 0 3 3 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW54859.1 - 2.2e-13 50.1 1.0 0.0014 18.7 0.0 3.5 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 CDW54859.1 - 6.9e-08 32.8 0.4 0.46 10.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 CDW54859.1 - 3.2e-06 27.1 0.2 1.3 9.1 0.0 4.0 3 2 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 CDW54859.1 - 6.7e-06 26.1 0.2 0.0032 17.5 0.0 3.2 3 0 0 3 3 3 1 C17orf99 Ig domain Ig_5 PF16681.5 CDW54859.1 - 2.8e-05 24.4 0.9 0.026 14.9 0.1 3.7 3 2 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 CDW54859.1 - 0.002 18.3 0.8 0.54 10.6 0.1 3.6 3 2 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Apc13p PF05839.11 CDW54859.1 - 0.0035 17.5 0.0 0.0071 16.5 0.0 1.5 1 0 0 1 1 1 1 Apc13p protein CDC48_2 PF02933.17 CDW54859.1 - 0.022 14.6 0.0 0.54 10.1 0.0 2.6 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), domain 2 I-set PF07679.16 CDW54860.1 - 4.1e-82 270.4 0.1 1.6e-16 60.1 0.2 5.6 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW54860.1 - 5.3e-54 180.7 0.4 9.7e-13 48.5 0.7 5.7 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 CDW54860.1 - 4e-26 91.2 7.1 1.9e-08 34.5 1.3 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 CDW54860.1 - 2.5e-25 88.5 4.6 1.9e-06 27.9 1.0 5.8 5 1 0 5 5 5 4 Immunoglobulin domain Spectrin PF00435.21 CDW54860.1 - 4e-11 43.3 13.8 1.2e-06 28.9 1.9 3.4 3 0 0 3 3 3 3 Spectrin repeat V-set PF07686.17 CDW54860.1 - 7.8e-11 42.1 4.2 1.1 9.5 0.2 7.1 6 2 1 7 7 7 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW54860.1 - 8.9e-07 28.9 0.8 0.15 12.1 0.1 4.6 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 CDW54860.1 - 3.3e-05 23.4 0.2 0.089 12.4 0.0 4.0 4 0 0 4 4 4 1 Immunoglobulin domain Receptor_2B4 PF11465.8 CDW54860.1 - 0.037 14.2 0.0 24 5.2 0.0 3.4 3 0 0 3 3 3 0 Natural killer cell receptor 2B4 Biotin_carb_C PF02785.19 CDW54860.1 - 0.043 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain DUF4363 PF14276.6 CDW54860.1 - 0.11 12.6 1.1 0.27 11.4 1.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Ig_C17orf99 PF17736.1 CDW54860.1 - 0.26 11.3 2.9 4.9 7.3 0.0 3.7 4 0 0 4 4 4 0 C17orf99 Ig domain Guanylate_kin PF00625.21 CDW54861.1 - 5.5e-43 146.8 0.0 1e-42 145.9 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase SH3_1 PF00018.28 CDW54861.1 - 2.7e-06 26.9 1.1 1.9e-05 24.2 1.0 2.5 2 1 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 CDW54861.1 - 3.6e-06 26.5 0.0 9.9e-06 25.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.6 CDW54861.1 - 0.00024 21.4 0.0 0.00071 19.8 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW54861.1 - 0.00028 20.7 0.7 0.0015 18.3 0.0 2.5 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.24 CDW54861.1 - 0.0031 17.8 0.1 0.0093 16.3 0.0 1.8 2 0 0 2 2 2 1 PDZ domain SH3_9 PF14604.6 CDW54861.1 - 0.0071 16.2 0.1 0.019 14.8 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain Tricorn_PDZ PF14685.6 CDW54861.1 - 0.0097 15.8 0.2 0.035 14.1 0.1 1.9 2 0 0 2 2 2 1 Tricorn protease PDZ domain PHD PF00628.29 CDW54862.1 - 6.4e-05 22.8 12.5 0.00014 21.7 12.5 1.6 1 0 0 1 1 1 1 PHD-finger DNA_pol_phi PF04931.13 CDW54862.1 - 0.02 13.0 1.9 0.04 12.0 1.9 1.4 1 0 0 1 1 1 0 DNA polymerase phi DUF3245 PF11595.8 CDW54862.1 - 0.78 10.2 15.4 1.4 9.4 8.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) NPR3 PF03666.13 CDW54862.1 - 0.79 8.4 10.4 0.31 9.8 7.9 1.6 1 1 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM176 PF14851.6 CDW54862.1 - 1.3 8.7 5.7 3.1 7.4 5.7 1.6 1 0 0 1 1 1 0 FAM176 family Peptidase_M48 PF01435.18 CDW54863.1 - 7e-11 42.3 0.4 1.2e-05 25.2 0.6 2.1 1 1 1 2 2 2 2 Peptidase family M48 Peptidase_M48 PF01435.18 CDW54864.1 - 2.5e-06 27.4 0.0 3.1e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M48_N PF16491.5 CDW54864.1 - 0.0036 17.2 0.1 0.005 16.8 0.1 1.2 1 0 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48_N PF16491.5 CDW54865.1 - 2.8e-11 43.7 4.0 4.7e-10 39.6 4.0 2.3 1 1 0 1 1 1 1 CAAX prenyl protease N-terminal, five membrane helices DnaJ_C PF01556.18 CDW54866.1 - 8.4e-41 139.5 0.0 1.1e-40 139.1 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDW54866.1 - 3.4e-27 94.3 4.5 2.4e-26 91.6 4.1 2.1 2 0 0 2 2 2 1 DnaJ domain RPT PF13446.6 CDW54866.1 - 0.063 13.2 0.0 0.2 11.6 0.0 1.8 1 1 1 2 2 2 0 A repeated domain in UCH-protein Y_phosphatase PF00102.27 CDW54867.1 - 4.8e-72 242.3 0.6 3.1e-71 239.7 0.6 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.24 CDW54867.1 - 3.5e-47 158.4 1.2 4e-22 78.1 0.0 3.9 3 1 0 3 3 3 2 SH2 domain DSPc PF00782.20 CDW54867.1 - 9.4e-05 22.2 0.0 0.00026 20.8 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CDW54867.1 - 0.00027 21.0 0.0 0.0013 18.8 0.0 2.0 2 1 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CDW54867.1 - 0.00055 20.1 1.2 0.001 19.2 0.0 2.1 3 0 0 3 3 3 1 Inositol hexakisphosphate JAB PF01398.21 CDW54868.1 - 1.2e-11 44.6 0.0 2.1e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDW54868.1 - 2.8e-07 30.9 0.1 4.6e-07 30.2 0.1 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Peptidase_M26_C PF07580.14 CDW54868.1 - 0.025 13.1 0.1 0.034 12.7 0.1 1.1 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase C-terminal region HTH_6 PF01418.17 CDW54868.1 - 0.15 12.1 0.1 0.54 10.3 0.2 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family EF-hand_7 PF13499.6 CDW54870.1 - 1.4e-26 92.7 3.8 5.3e-17 62.0 0.2 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 CDW54870.1 - 4.3e-25 85.4 6.0 1.2e-07 30.8 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CDW54870.1 - 1.1e-22 77.9 3.5 6.5e-06 25.7 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CDW54870.1 - 3.7e-20 70.4 7.6 2.6e-05 23.5 0.1 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 CDW54870.1 - 7.7e-14 51.3 6.5 0.00013 21.8 0.4 3.8 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW54870.1 - 6.8e-07 29.6 0.5 0.031 14.6 0.0 3.2 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CDW54870.1 - 9.5e-06 25.8 0.2 0.043 14.2 0.0 3.1 2 1 1 3 3 3 1 EF-hand domain EF-hand_4 PF12763.7 CDW54870.1 - 1.2e-05 25.2 2.8 0.22 11.5 0.1 3.4 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CDW54870.1 - 0.006 16.8 0.3 0.56 10.4 0.1 2.7 2 1 1 3 3 3 1 Dockerin type I domain EF-hand_10 PF14788.6 CDW54870.1 - 0.046 13.6 1.3 10 6.1 0.0 3.3 4 0 0 4 4 4 0 EF hand Pam16 PF03656.13 CDW54870.1 - 0.09 12.8 0.1 24 4.9 0.0 3.0 2 1 2 4 4 4 0 Pam16 Caleosin PF05042.13 CDW54870.1 - 0.1 12.5 0.8 25 4.8 0.0 3.1 2 1 1 3 3 3 0 Caleosin related protein Trypsin PF00089.26 CDW54871.1 - 3.8e-05 23.6 0.3 0.00014 21.7 0.0 2.1 2 0 0 2 2 2 1 Trypsin SR-25 PF10500.9 CDW54871.1 - 0.31 10.6 10.0 0.49 10.0 10.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Trypsin PF00089.26 CDW54872.1 - 5.5e-29 101.6 0.0 2e-08 34.3 0.0 3.5 3 0 0 3 3 3 3 Trypsin PHO4 PF01384.20 CDW54873.1 - 2.8e-60 204.1 2.2 3.9e-60 203.7 2.2 1.3 1 0 0 1 1 1 1 Phosphate transporter family DUF997 PF06196.12 CDW54873.1 - 0.42 10.7 9.6 1.2 9.2 0.2 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF997) Sm_multidrug_ex PF06695.11 CDW54873.1 - 0.42 11.3 4.7 0.43 11.2 0.7 2.7 2 1 0 2 2 2 0 Putative small multi-drug export protein UvdE PF03851.14 CDW54875.1 - 1.2e-53 182.1 0.0 1.5e-53 181.9 0.0 1.0 1 0 0 1 1 1 1 UV-endonuclease UvdE AP_endonuc_2 PF01261.24 CDW54875.1 - 3.2e-06 26.8 0.0 0.0026 17.2 0.0 2.1 1 1 1 2 2 2 2 Xylose isomerase-like TIM barrel SAM_1 PF00536.30 CDW54876.1 - 4.2e-21 75.2 3.4 1.3e-09 38.3 0.1 4.3 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW54876.1 - 5.7e-20 71.2 0.6 2.1e-06 27.7 0.1 4.0 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) DUF2783 PF10932.8 CDW54876.1 - 0.078 12.7 0.0 0.24 11.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2783) zf-C2H2 PF00096.26 CDW54877.1 - 1.3e-07 31.7 42.3 0.00036 20.8 2.1 5.6 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW54877.1 - 2.5e-06 27.8 38.1 0.019 15.8 1.8 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger Actin_micro PF17003.5 CDW54877.1 - 0.00017 20.9 10.9 0.35 10.0 2.3 3.9 2 2 2 4 4 4 3 Putative actin-like family OrsD PF12013.8 CDW54877.1 - 0.00086 19.7 16.4 0.0083 16.6 0.9 4.6 1 1 2 4 4 4 2 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_3rep PF18868.1 CDW54877.1 - 0.0097 16.6 12.1 0.032 14.9 1.4 3.5 2 1 1 3 3 3 1 Zinc finger C2H2-type, 3 repeats zf-H2C2_5 PF13909.6 CDW54877.1 - 0.01 15.6 25.4 0.13 12.0 0.2 6.1 5 1 0 5 5 5 0 C2H2-type zinc-finger domain DUF629 PF04780.12 CDW54877.1 - 0.02 13.4 10.3 0.2 10.1 0.9 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF629) zf_C2H2_ZHX PF18387.1 CDW54877.1 - 0.04 13.6 26.5 0.21 11.3 2.0 5.0 2 1 3 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain Rubredoxin_2 PF18073.1 CDW54877.1 - 0.29 10.9 0.1 0.29 10.9 0.1 4.0 4 0 0 4 4 4 0 Rubredoxin metal binding domain Zn-ribbon_8 PF09723.10 CDW54877.1 - 0.49 10.5 5.8 5 7.3 0.2 3.8 3 0 0 3 3 3 0 Zinc ribbon domain DUF3268 PF11672.8 CDW54877.1 - 0.6 10.5 11.3 3.2 8.1 0.9 3.8 4 0 0 4 4 4 0 zinc-finger-containing domain zf-MYST PF17772.1 CDW54877.1 - 0.76 9.4 3.8 5.3 6.7 0.0 3.4 3 0 0 3 3 3 0 MYST family zinc finger domain zinc_ribbon_4 PF13717.6 CDW54877.1 - 0.89 9.5 5.2 3 7.8 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain PHD PF00628.29 CDW54877.1 - 2.6 8.0 8.4 37 4.3 0.1 4.1 3 1 0 3 3 3 0 PHD-finger zf-H2C2_2 PF13465.6 CDW54877.1 - 3.8 8.1 33.4 0.14 12.6 0.8 5.8 6 0 0 6 6 5 0 Zinc-finger double domain zf-C2H2_11 PF16622.5 CDW54877.1 - 7.8 6.4 20.4 0.19 11.5 1.6 4.3 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-met2 PF12907.7 CDW54877.1 - 9.9 6.4 11.8 6.6 7.0 0.9 3.9 4 0 0 4 4 4 0 Zinc-binding Peptidase_M8 PF01457.16 CDW54878.1 - 1.1e-09 37.5 0.3 6.3e-07 28.5 0.0 2.1 1 1 1 2 2 2 2 Leishmanolysin Aa_trans PF01490.18 CDW54879.1 - 8.3e-68 229.0 27.1 2.5e-66 224.1 27.1 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein APOBEC_N PF08210.11 CDW54880.1 - 2.2e-16 60.3 3.3 4.2e-16 59.4 3.3 1.6 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 CDW54880.1 - 0.00044 20.4 3.0 0.0037 17.4 0.7 2.6 2 1 0 2 2 2 1 Novel AID APOBEC clade 1 Fib_alpha PF08702.10 CDW54881.1 - 0.005 17.0 4.4 0.0054 16.9 1.3 2.4 2 1 0 2 2 2 1 Fibrinogen alpha/beta chain family DUF4349 PF14257.6 CDW54881.1 - 0.06 12.8 1.6 0.073 12.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) YabA PF06156.13 CDW54881.1 - 0.12 13.0 10.6 3 8.6 1.4 3.2 3 0 0 3 3 3 0 Initiation control protein YabA FlxA PF14282.6 CDW54881.1 - 0.14 12.1 3.8 7.1 6.7 0.3 2.9 3 0 0 3 3 3 0 FlxA-like protein BST2 PF16716.5 CDW54881.1 - 0.15 12.7 0.4 0.15 12.7 0.4 3.8 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 ZapB PF06005.12 CDW54881.1 - 0.16 12.4 11.8 0.78 10.2 1.5 3.3 3 0 0 3 3 3 0 Cell division protein ZapB Rbsn PF11464.8 CDW54881.1 - 0.19 11.5 4.2 3.7 7.4 0.4 3.2 3 0 0 3 3 3 0 Rabenosyn Rab binding domain TSC22 PF01166.18 CDW54881.1 - 0.29 11.5 8.2 7.1 7.0 0.4 3.5 3 0 0 3 3 3 0 TSC-22/dip/bun family DivIC PF04977.15 CDW54881.1 - 0.52 10.1 9.6 5.9 6.7 0.8 3.4 3 0 0 3 3 3 0 Septum formation initiator SlyX PF04102.12 CDW54881.1 - 0.84 10.3 9.1 1.5 9.5 0.9 3.1 3 0 0 3 3 3 0 SlyX DUF4618 PF15397.6 CDW54881.1 - 1.2 8.5 11.6 0.57 9.6 0.7 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) Csm1_N PF18504.1 CDW54881.1 - 1.4 9.3 14.0 5.6 7.4 0.7 3.5 3 0 0 3 3 3 0 Csm1 N-terminal domain bZIP_1 PF00170.21 CDW54881.1 - 3.6 7.8 12.4 5.8 7.1 0.3 3.9 3 1 1 4 4 4 0 bZIP transcription factor DUF16 PF01519.16 CDW54881.1 - 4.5 7.8 10.1 0.95 10.0 1.7 3.0 2 1 1 3 3 3 0 Protein of unknown function DUF16 G-gamma PF00631.22 CDW54881.1 - 5.3 7.1 5.8 6.9 6.8 0.0 3.0 3 0 0 3 3 3 0 GGL domain DUF1192 PF06698.11 CDW54881.1 - 5.7 7.1 10.8 3.2 7.9 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) TPR_MLP1_2 PF07926.12 CDW54881.1 - 8.2 6.5 11.6 3.1 7.9 1.1 2.9 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Tetraspanin PF00335.20 CDW54882.1 - 1.3e-42 146.0 9.5 1.6e-42 145.8 9.5 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF4064 PF13273.6 CDW54882.1 - 0.022 15.0 2.5 1.6 9.0 1.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) DUF1218 PF06749.12 CDW54882.1 - 0.068 13.7 5.4 0.51 10.9 3.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) MFS_1 PF07690.16 CDW54883.1 - 2.1e-36 125.6 32.1 2.2e-36 125.5 31.1 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4131 PF13567.6 CDW54883.1 - 0.092 12.4 5.1 1.9 8.1 0.6 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Aminotran_3 PF00202.21 CDW54884.1 - 2.2e-113 379.0 0.0 2.6e-113 378.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III SMC_N PF02463.19 CDW54885.1 - 3e-15 56.3 0.0 2e-14 53.5 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDW54885.1 - 3.2e-10 40.9 0.0 5.8e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 CDW54885.1 - 1.3e-08 35.0 0.0 0.00036 20.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDW54885.1 - 5.6e-05 23.0 0.0 0.00015 21.6 0.0 1.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 CDW54885.1 - 0.00013 21.7 0.0 0.00027 20.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CDW54885.1 - 0.02 14.5 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_27 PF13514.6 CDW54885.1 - 0.03 13.9 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDW54885.1 - 0.034 14.6 0.0 0.076 13.5 0.0 1.6 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 CDW54885.1 - 0.13 12.2 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain DUF2813 PF11398.8 CDW54885.1 - 0.18 11.1 0.0 0.33 10.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) Sugar_tr PF00083.24 CDW54886.1 - 7.1e-105 351.5 31.2 1.7e-82 277.7 14.5 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CDW54886.1 - 4.2e-32 111.5 27.6 3.2e-30 105.2 17.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CDW54886.1 - 0.00013 20.7 27.1 0.00088 17.9 5.9 3.9 4 0 0 4 4 4 3 MFS/sugar transport protein TRI12 PF06609.13 CDW54886.1 - 0.0011 17.4 1.8 0.0026 16.3 1.8 1.6 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1279 PF06916.13 CDW54886.1 - 0.024 15.2 0.1 0.13 12.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1279) MFS_1_like PF12832.7 CDW54886.1 - 0.088 11.6 14.3 0.011 14.6 4.5 2.9 3 1 0 3 3 3 0 MFS_1 like family MFS_3 PF05977.13 CDW54886.1 - 0.17 10.2 14.8 0.0085 14.5 6.7 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector Myotub-related PF06602.14 CDW54887.1 - 3.7e-126 420.8 0.1 5.7e-126 420.2 0.1 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.21 CDW54887.1 - 1.5e-19 69.8 11.4 5e-19 68.2 11.4 2.0 1 0 0 1 1 1 1 FYVE zinc finger DSPc PF00782.20 CDW54887.1 - 0.00092 19.0 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW54887.1 - 0.0025 17.4 0.0 0.0046 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW54887.1 - 0.013 15.5 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family FYVE_2 PF02318.16 CDW54887.1 - 0.16 12.2 12.3 0.075 13.2 7.0 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger IBR PF01485.21 CDW54887.1 - 0.53 10.5 8.5 0.68 10.2 5.0 3.0 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Ribonuclease_3 PF00636.26 CDW54888.1 - 6.5e-55 184.2 0.0 5.5e-30 104.1 0.0 2.9 2 0 0 2 2 2 2 Ribonuclease III domain PAZ PF02170.22 CDW54888.1 - 6.2e-35 120.0 0.1 1.9e-34 118.4 0.1 1.8 1 0 0 1 1 1 1 PAZ domain Ribonucleas_3_3 PF14622.6 CDW54888.1 - 9.1e-29 100.2 0.8 2.5e-18 66.5 0.1 5.1 4 1 0 4 4 4 3 Ribonuclease-III-like Dicer_dimer PF03368.14 CDW54888.1 - 1.1e-22 80.0 0.0 6.2e-22 77.6 0.0 2.4 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 CDW54888.1 - 5.7e-06 26.7 0.0 1.5e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TPR_12 PF13424.6 CDW54889.1 - 1.4e-06 28.5 1.1 0.00092 19.5 0.2 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDW54889.1 - 3.8e-05 23.4 1.1 0.001 19.0 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDW54889.1 - 7.8e-05 22.3 3.3 0.00065 19.4 0.3 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW54889.1 - 0.00019 21.4 6.6 0.0014 18.7 0.6 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW54889.1 - 0.0018 18.3 7.8 0.015 15.4 0.6 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat NBP1 PF08537.10 CDW54889.1 - 0.0068 15.9 0.9 0.0085 15.5 0.9 1.3 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 TPR_6 PF13174.6 CDW54889.1 - 0.17 12.6 4.0 0.29 11.8 1.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat IRK_C PF17655.1 CDW54890.1 - 7.8e-68 227.5 0.0 1e-67 227.1 0.0 1.1 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 CDW54890.1 - 2.3e-43 147.4 5.6 3.8e-43 146.7 5.6 1.4 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain CDC45 PF02724.14 CDW54891.1 - 7.6e-93 311.9 10.7 4.6e-51 173.9 2.4 3.0 1 1 2 3 3 3 3 CDC45-like protein Pyridoxal_deC PF00282.19 CDW54892.1 - 6.9e-133 443.0 0.0 7.9e-133 442.8 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CDW54892.1 - 2.8e-07 30.1 0.0 3.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CDW54892.1 - 0.00053 19.3 0.0 0.0008 18.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II SepSecS PF05889.13 CDW54892.1 - 0.0017 17.1 0.0 0.0025 16.6 0.0 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Aminotran_5 PF00266.19 CDW54892.1 - 0.069 12.1 0.0 0.096 11.6 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class-V LBP_BPI_CETP_C PF02886.17 CDW54893.1 - 6.1e-26 91.3 0.0 1.2e-25 90.3 0.0 1.5 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 CDW54893.1 - 2.7e-08 33.6 0.0 5.7e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Homeodomain PF00046.29 CDW54894.1 - 2.9e-27 94.3 14.7 4.2e-11 42.5 1.5 4.7 5 0 0 5 5 5 3 Homeodomain Homeobox_KN PF05920.11 CDW54894.1 - 8.7e-12 44.8 0.1 0.00037 20.3 0.0 3.6 3 0 0 3 3 3 2 Homeobox KN domain Homez PF11569.8 CDW54894.1 - 2.1e-05 23.9 1.4 0.25 10.8 0.0 3.2 3 0 0 3 3 3 2 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 CDW54894.1 - 2.5e-05 24.0 0.0 1.9 8.4 0.0 3.5 3 0 0 3 3 3 2 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phage_terminase PF10668.9 CDW54894.1 - 0.0026 17.7 0.1 6 7.0 0.0 3.4 3 0 0 3 3 3 1 Phage terminase small subunit HTH_36 PF13730.6 CDW54894.1 - 0.0051 16.7 0.1 0.86 9.6 0.0 2.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDW54894.1 - 0.0071 16.1 1.1 4 7.4 0.1 3.5 3 0 0 3 3 3 1 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 CDW54894.1 - 0.015 14.7 0.1 17 4.9 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 LTXXQ PF07813.12 CDW54894.1 - 0.08 13.7 0.0 4.4 8.1 0.0 2.8 3 0 0 3 3 2 0 LTXXQ motif family protein DUF1199 PF06712.11 CDW54894.1 - 0.12 12.4 2.3 0.12 12.4 0.0 2.3 2 0 0 2 2 1 0 Protein of unknown function (DUF1199) HTH_31 PF13560.6 CDW54894.1 - 0.14 12.5 0.3 1.8e+02 2.6 0.0 4.3 5 0 0 5 5 5 0 Helix-turn-helix domain Sds3 PF08598.11 CDW54896.1 - 0.00034 20.7 0.1 0.00034 20.7 0.1 2.9 2 1 0 2 2 2 1 Sds3-like PhaP_Bmeg PF09602.10 CDW54896.1 - 0.7 9.8 7.1 0.74 9.7 1.7 2.6 2 1 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF1682 PF07946.14 CDW54897.1 - 3.4e-83 279.5 0.2 4.5e-83 279.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) RPN2_C PF18004.1 CDW54897.1 - 1.2 9.1 11.5 2.3 8.1 11.5 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Tubulin-binding PF00418.19 CDW54898.1 - 1.7e-17 63.1 3.8 3.8e-16 58.8 0.9 2.1 2 0 0 2 2 2 2 Tau and MAP protein, tubulin-binding repeat Tmemb_cc2 PF10267.9 CDW54898.1 - 0.2 10.8 0.0 0.22 10.7 0.0 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Pyridoxal_deC PF00282.19 CDW54899.1 - 1.4e-95 320.2 0.0 1.1e-63 215.3 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain FLYWCH PF04500.16 CDW54900.1 - 9e-16 57.7 10.9 9.5e-10 38.4 0.2 2.6 2 0 0 2 2 2 2 FLYWCH zinc finger domain MULE PF10551.9 CDW54900.1 - 2.3e-09 37.5 0.6 2.9e-08 34.0 0.1 2.6 2 0 0 2 2 2 1 MULE transposase domain MULE PF10551.9 CDW54901.1 - 1.9e-16 60.3 0.0 1.1e-15 57.8 0.0 2.1 2 0 0 2 2 2 1 MULE transposase domain FLYWCH PF04500.16 CDW54901.1 - 1.3e-12 47.7 5.9 2.5e-12 46.7 5.9 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain CBS PF00571.28 CDW54902.1 - 1e-28 99.5 6.1 2.5e-08 34.2 0.4 4.3 4 0 0 4 4 4 4 CBS domain ThiS PF02597.20 CDW54904.1 - 8e-09 36.0 0.0 1.7e-08 35.0 0.0 1.5 1 1 0 1 1 1 1 ThiS family HA2 PF04408.23 CDW54905.1 - 7.2e-20 71.3 0.2 7.2e-20 71.3 0.2 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDW54905.1 - 3.3e-14 53.0 0.0 8.1e-14 51.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDW54905.1 - 2.6e-11 43.8 0.0 1.6e-09 38.1 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW54905.1 - 4.9e-10 39.5 0.2 1.1e-09 38.3 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDW54905.1 - 0.00051 20.3 0.1 0.002 18.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 CDW54905.1 - 0.0031 16.9 0.1 0.007 15.7 0.1 1.5 1 0 0 1 1 1 1 KaiC AAA_19 PF13245.6 CDW54905.1 - 0.0037 17.6 0.1 0.0073 16.7 0.1 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDW54905.1 - 0.0056 15.8 0.1 0.015 14.4 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 CDW54905.1 - 0.0064 16.2 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 CDW54905.1 - 0.026 13.9 0.0 0.13 11.6 0.0 2.1 3 0 0 3 3 3 0 FtsK/SpoIIIE family PhoH PF02562.16 CDW54905.1 - 0.082 12.3 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 CDW54905.1 - 0.11 13.0 0.0 0.36 11.3 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 CDW54905.1 - 0.14 12.6 10.6 1.1 9.7 0.0 2.9 2 1 0 2 2 2 0 AAA domain DUF4315 PF14193.6 CDW54905.1 - 3.9 7.6 13.3 17 5.5 7.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) Bcl-2 PF00452.19 CDW54906.1 - 6.4e-27 94.2 0.0 1.2e-26 93.3 0.0 1.4 1 0 0 1 1 1 1 Apoptosis regulator proteins, Bcl-2 family P34-Arc PF04045.14 CDW54907.1 - 3.2e-92 308.6 0.0 3.9e-92 308.3 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc fn3 PF00041.21 CDW54909.1 - 5.3e-09 36.3 0.0 0.04 14.3 0.0 4.3 3 2 0 3 3 3 3 Fibronectin type III domain LSM PF01423.22 CDW54911.1 - 1.3e-19 69.7 0.0 1.5e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDW54911.1 - 0.0087 16.2 0.0 0.0097 16.0 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain KTI12 PF08433.10 CDW54915.1 - 1.2e-05 24.9 0.0 0.13 11.7 0.0 2.2 1 1 1 2 2 2 2 Chromatin associated protein KTI12 AAA_33 PF13671.6 CDW54915.1 - 0.00011 22.4 0.1 0.0045 17.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 CDW54915.1 - 0.0022 18.3 0.0 0.0048 17.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 CDW54915.1 - 0.01 15.5 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 CDW54915.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CDW54915.1 - 0.013 14.8 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_17 PF13207.6 CDW54915.1 - 0.016 15.6 0.0 0.048 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain 6PF2K PF01591.18 CDW54915.1 - 0.021 14.1 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA PF00004.29 CDW54915.1 - 0.027 14.9 0.0 0.044 14.2 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CDW54915.1 - 0.055 13.2 0.0 0.097 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDW54915.1 - 0.079 13.3 0.0 0.14 12.5 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 CDW54915.1 - 0.089 12.8 0.0 0.27 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) GCIP PF13324.6 CDW54916.1 - 0.073 12.7 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Adeno_E3_CR2 PF02439.15 CDW54916.1 - 7.6 6.4 6.2 1.3 8.9 2.5 1.6 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 His_Phos_2 PF00328.22 CDW54918.1 - 6.7e-106 354.9 0.4 8.1e-106 354.6 0.4 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 CDW54918.1 - 2.5e-33 114.1 0.1 5.9e-33 112.9 0.1 1.7 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 CDW54918.1 - 0.0072 15.9 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Histone PF00125.24 CDW54919.1 - 7.2e-34 117.0 1.4 1e-33 116.5 1.4 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW54919.1 - 0.003 17.8 0.5 0.0085 16.4 0.0 2.0 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 CDW54919.1 - 0.043 14.0 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Zip PF02535.22 CDW54920.1 - 7.1e-57 193.1 6.5 1.5e-56 192.0 6.5 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1345 PF07077.11 CDW54920.1 - 0.15 11.8 1.4 2.6 7.7 0.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1345) DUF1129 PF06570.11 CDW54920.1 - 0.33 10.4 3.0 2.6 7.5 0.4 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) ABC2_membrane PF01061.24 CDW54920.1 - 8.3 5.8 18.0 0.88 8.9 1.6 3.6 3 1 1 4 4 4 0 ABC-2 type transporter Ribosomal_S10 PF00338.22 CDW54921.1 - 9.3e-16 57.9 0.0 1.4e-15 57.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF4078 PF13300.6 CDW54922.1 - 7.4e-21 74.3 13.0 7.4e-21 74.3 13.0 3.0 3 1 1 4 4 4 1 Domain of unknown function (DUF4078) DUF2514 PF10721.9 CDW54922.1 - 4 7.5 16.9 2.3 8.2 7.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) DPPIV_N PF00930.21 CDW54923.1 - 2e-15 56.4 0.0 2.8e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CDW54924.1 - 3.4e-51 173.7 0.1 5.2e-51 173.1 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.21 CDW54924.1 - 3.5e-15 55.6 0.0 5.3e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S15 PF02129.18 CDW54924.1 - 6e-12 45.7 0.3 3.5e-11 43.2 0.2 2.0 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 CDW54924.1 - 6.7e-09 35.6 0.0 2.9e-08 33.5 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CDW54924.1 - 1.7e-06 27.9 0.1 3.1e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW54924.1 - 9.7e-06 26.3 0.2 1.9e-05 25.4 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 CDW54924.1 - 0.00017 21.3 0.3 0.00033 20.4 0.0 1.5 2 0 0 2 2 2 1 Putative esterase LIP PF03583.14 CDW54924.1 - 0.00028 20.3 0.1 0.00053 19.4 0.1 1.3 1 0 0 1 1 1 1 Secretory lipase Hydrolase_4 PF12146.8 CDW54924.1 - 0.00032 20.0 0.4 0.025 13.9 0.1 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CDW54924.1 - 0.0019 18.1 0.1 2.2 8.0 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Tannase PF07519.11 CDW54924.1 - 0.0049 15.8 0.8 2.3 7.0 0.6 2.8 1 1 1 2 2 2 2 Tannase and feruloyl esterase Abhydrolase_3 PF07859.13 CDW54924.1 - 0.0091 15.9 0.1 0.064 13.1 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 CDW54924.1 - 0.024 13.2 0.0 0.038 12.5 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II DUF2920 PF11144.8 CDW54924.1 - 0.11 11.6 0.1 0.19 10.8 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2920) AXE1 PF05448.12 CDW54924.1 - 0.16 10.6 0.0 0.81 8.3 0.0 1.9 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Motile_Sperm PF00635.26 CDW54925.1 - 1.1e-17 63.9 0.8 1.6e-17 63.3 0.8 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Motile_Sperm PF00635.26 CDW54926.1 - 6e-17 61.5 1.2 6.3e-17 61.4 0.1 1.6 2 0 0 2 2 2 1 MSP (Major sperm protein) domain Carb_kinase PF01256.17 CDW54927.1 - 1.4e-51 175.3 0.0 1.7e-51 175.0 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 CDW54927.1 - 0.021 14.2 0.0 0.043 13.2 0.0 1.6 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family DUF1971 PF09313.11 CDW54927.1 - 0.072 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) PfkB PF00294.24 CDW54927.1 - 0.081 12.2 0.0 0.29 10.4 0.0 1.7 1 1 0 2 2 2 0 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CDW54927.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.5 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase SIR2 PF02146.17 CDW54928.1 - 1.3e-57 194.6 0.0 2e-57 194.0 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CDW54928.1 - 0.00011 21.9 0.0 0.42 10.4 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF592 PF04574.13 CDW54928.1 - 0.00018 21.3 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) Zn-ribbon_8 PF09723.10 CDW54928.1 - 3.6 7.8 5.5 1.7 8.8 0.7 2.7 3 0 0 3 3 3 0 Zinc ribbon domain Isochorismatase PF00857.20 CDW54929.1 - 5.4e-39 134.2 0.0 6e-39 134.0 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family TerY_C PF15616.6 CDW54929.1 - 0.017 15.3 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain NtA PF03146.15 CDW54929.1 - 0.038 13.8 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 Agrin NtA domain stn_TNFRSF12A PF12191.8 CDW54930.1 - 0.0096 16.1 1.0 0.027 14.7 0.1 2.2 2 0 0 2 2 2 1 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain DUF5527 PF17665.1 CDW54930.1 - 1.5 8.4 15.5 0.076 12.5 0.7 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5527) UCH PF00443.29 CDW54931.1 - 3.4e-37 128.3 0.0 8e-36 123.8 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW54931.1 - 2.1e-14 53.8 0.0 1.3e-11 44.7 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ras PF00071.22 CDW54932.1 - 3e-53 179.7 0.0 3.4e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW54932.1 - 5.6e-19 68.5 0.0 1e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW54932.1 - 5.8e-08 32.4 0.0 7.5e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW54932.1 - 0.0026 17.3 0.1 0.014 14.9 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PET117 PF15786.5 CDW54932.1 - 0.043 14.1 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial MCM PF00493.23 CDW54933.1 - 1e-101 338.7 0.0 1.7e-101 338.0 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDW54933.1 - 3.1e-32 111.1 0.7 6.8e-32 110.0 0.7 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDW54933.1 - 6e-23 81.1 1.8 8.3e-22 77.4 0.6 2.6 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 CDW54933.1 - 1e-19 71.1 2.0 1.4e-19 70.6 1.1 1.8 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CDW54933.1 - 1.5e-06 27.8 0.0 4e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDW54933.1 - 2.6e-06 27.5 0.0 9.4e-06 25.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDW54933.1 - 0.0043 16.9 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Transketolase_C PF02780.20 CDW54933.1 - 0.0052 16.7 0.2 0.016 15.1 0.1 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain AAA_lid_2 PF17863.1 CDW54933.1 - 0.013 15.3 1.2 0.066 13.1 0.1 2.7 3 0 0 3 3 3 0 AAA lid domain ROK PF00480.20 CDW54933.1 - 0.044 13.2 0.1 6.6 6.1 0.0 2.5 2 0 0 2 2 2 0 ROK family Collagen PF01391.18 CDW54934.1 - 1e-220 713.8 789.5 2.9e-10 39.8 19.5 29.8 2 2 24 27 27 27 26 Collagen triple helix repeat (20 copies) C4 PF01413.19 CDW54934.1 - 6.2e-80 264.8 4.6 3.5e-42 143.3 0.2 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen Ion_trans_2 PF07885.16 CDW54935.1 - 2.9e-34 116.9 18.7 4.4e-18 65.0 2.1 2.9 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CDW54935.1 - 7.9e-08 31.8 2.0 0.0026 17.0 0.0 2.2 1 1 1 2 2 2 2 Ion transport protein RRM_1 PF00076.22 CDW54937.1 - 4e-89 292.5 7.2 1.9e-22 78.8 0.3 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CDW54937.1 - 2.6e-27 94.8 3.2 3.3e-27 94.5 1.0 2.4 3 0 0 3 3 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 CDW54937.1 - 1.4e-08 34.4 1.0 0.043 13.4 0.0 4.4 1 1 2 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW54937.1 - 3.1e-08 33.6 1.0 0.28 11.3 0.1 5.0 4 1 0 4 4 4 2 RNA recognition motif Nup35_RRM PF05172.13 CDW54937.1 - 3.3e-07 30.2 0.2 0.1 12.6 0.1 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 CDW54937.1 - 2e-06 27.7 1.8 1.5 8.9 0.1 4.4 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CDW54937.1 - 1.1e-05 25.4 7.3 0.4 10.8 0.7 4.2 4 0 0 4 4 4 2 RNA binding motif SET_assoc PF11767.8 CDW54937.1 - 4.1e-05 23.2 0.6 15 5.3 0.0 4.5 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated DUF4523 PF15023.6 CDW54937.1 - 8.5e-05 22.4 0.0 3.4 7.5 0.0 4.1 2 1 2 4 4 4 1 Protein of unknown function (DUF4523) RRM_occluded PF16842.5 CDW54937.1 - 0.00013 21.7 0.0 1.5 8.7 0.0 3.6 3 0 0 3 3 3 2 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CDW54937.1 - 0.0013 18.7 1.0 31 4.7 0.0 4.4 4 0 0 4 4 4 0 Limkain b1 PHM7_cyt PF14703.6 CDW54937.1 - 0.043 14.1 7.2 2.7 8.2 0.0 5.3 4 1 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter DUF918 PF06033.11 CDW54937.1 - 0.17 11.9 0.1 9.4 6.2 0.0 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF918) PhetRS_B1 PF18262.1 CDW54937.1 - 0.22 11.8 1.6 6.5 7.0 0.1 3.1 3 0 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain Histone PF00125.24 CDW54938.1 - 2.4e-21 76.5 0.2 3e-21 76.1 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW54938.1 - 9.2e-07 29.1 1.3 9.7e-07 29.0 0.2 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW54938.1 - 0.003 17.6 0.1 0.0034 17.4 0.1 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 CDW54938.1 - 0.013 16.0 0.5 0.02 15.4 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Acyl-CoA_dh_1 PF00441.24 CDW54939.1 - 2.5e-43 147.8 2.0 1.2e-42 145.6 2.0 2.0 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CDW54939.1 - 1.4e-24 86.1 0.1 2.4e-24 85.3 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CDW54939.1 - 7.9e-20 71.6 0.0 2e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CDW54939.1 - 9.4e-18 64.8 0.2 1.8e-17 63.9 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CDW54939.1 - 0.023 14.4 0.1 0.072 12.7 0.1 1.8 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal CBM_14 PF01607.24 CDW54940.1 - 1.1e-79 262.5 98.5 2.8e-09 37.0 5.3 9.4 9 0 0 9 9 9 9 Chitin binding Peritrophin-A domain SSI PF00720.17 CDW54940.1 - 0.6 10.1 29.2 4.8 7.2 0.5 7.4 7 0 0 7 7 7 0 Subtilisin inhibitor-like EIF_2_alpha PF07541.12 CDW54941.1 - 1.6e-32 112.0 0.1 2.6e-32 111.3 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 CDW54941.1 - 3.6e-14 52.9 0.4 6.2e-14 52.1 0.4 1.4 1 0 0 1 1 1 1 S1 RNA binding domain UEV PF05743.13 CDW54942.1 - 6.3e-26 90.6 0.1 1.5e-25 89.4 0.1 1.6 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 CDW54942.1 - 2.7e-24 84.9 0.5 6.1e-24 83.7 0.2 1.8 2 0 0 2 2 2 1 Vps23 core domain MRP-S23 PF10484.9 CDW54942.1 - 0.16 12.2 0.1 0.64 10.3 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal protein S23 Med28 PF11594.8 CDW54942.1 - 0.19 11.8 0.2 1.7 8.7 0.1 2.0 1 1 0 2 2 2 0 Mediator complex subunit 28 SET PF00856.28 CDW54943.1 - 0.0032 17.9 0.0 0.27 11.6 0.0 2.2 1 1 0 1 1 1 1 SET domain PHF5 PF03660.14 CDW54943.1 - 0.024 14.8 1.5 0.039 14.2 1.5 1.2 1 0 0 1 1 1 0 PHF5-like protein SAF PF08666.12 CDW54943.1 - 0.077 13.6 0.0 0.3 11.7 0.0 1.9 2 0 0 2 2 2 0 SAF domain Pkinase PF00069.25 CDW54944.1 - 3.6e-34 118.3 0.0 5.4e-34 117.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54944.1 - 1.1e-32 113.4 0.0 4.9e-32 111.2 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 CDW54944.1 - 3.4e-10 39.2 0.2 6.5e-10 38.3 0.2 1.5 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif Activin_recp PF01064.23 CDW54944.1 - 0.0007 20.6 1.2 0.0007 20.6 1.2 2.2 2 0 0 2 2 2 1 Activin types I and II receptor domain G6PD_C PF02781.16 CDW54945.1 - 9.1e-114 379.5 0.0 1.4e-113 379.0 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CDW54945.1 - 4.2e-57 193.6 0.0 6.6e-57 193.0 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Laminin_EGF PF00053.24 CDW54946.1 - 2.1e-103 338.3 270.3 4.8e-12 45.8 14.1 14.5 14 0 0 14 14 13 13 Laminin EGF domain Laminin_N PF00055.17 CDW54946.1 - 2.1e-80 269.7 0.0 1.2e-79 267.2 0.0 2.5 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) DUF1664 PF07889.12 CDW54946.1 - 0.002 18.1 4.6 0.002 18.1 4.6 4.5 3 1 2 5 5 5 1 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 CDW54946.1 - 0.0054 16.7 12.0 0.0054 16.7 12.0 4.2 3 2 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 F5_F8_type_C PF00754.25 CDW54946.1 - 0.0064 16.6 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 F5/8 type C domain DUF4201 PF13870.6 CDW54946.1 - 0.0066 16.2 1.2 0.0066 16.2 1.2 4.5 5 1 0 5 5 4 1 Domain of unknown function (DUF4201) BNR_6 PF15899.5 CDW54946.1 - 0.075 13.1 0.6 0.19 11.8 0.6 1.6 1 0 0 1 1 1 0 BNR-Asp box repeat DUF3138 PF11336.8 CDW54946.1 - 0.85 8.2 9.3 4.1 5.9 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) FlaC_arch PF05377.11 CDW54946.1 - 1.5 9.2 12.0 0.16 12.4 0.8 4.4 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 CDW54946.1 - 4.7 7.0 25.9 0.38 10.6 2.7 4.6 4 0 0 4 4 4 0 Septum formation initiator DUF2935 PF11155.8 CDW54946.1 - 7.4 6.9 7.0 2.1e+02 2.3 0.0 4.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) CDC37_C PF08564.10 CDW54947.1 - 1.4e-07 31.6 3.7 1.9e-07 31.1 0.1 2.4 2 0 0 2 2 2 1 Cdc37 C terminal domain CDC37_N PF03234.14 CDW54947.1 - 2.5e-06 28.4 11.4 2.5e-06 28.4 11.4 2.3 2 1 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 CDW54947.1 - 4.3e-06 26.6 2.0 6.1e-06 26.1 0.1 2.1 3 0 0 3 3 3 1 Cdc37 Hsp90 binding domain Mod_r PF07200.13 CDW54947.1 - 0.077 13.1 9.4 0.035 14.2 4.3 2.3 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein RRM_1 PF00076.22 CDW54948.1 - 1.4e-35 120.9 0.0 1.2e-16 60.2 0.1 3.5 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 CDW54948.1 - 4.3e-23 82.2 0.1 1.2e-22 80.8 0.1 1.8 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 CDW54948.1 - 0.016 15.0 0.0 0.2 11.6 0.0 2.7 3 0 0 3 3 3 0 Occluded RNA-recognition motif UCH PF00443.29 CDW54949.1 - 7.1e-37 127.3 0.0 1.2e-36 126.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CDW54949.1 - 2.9e-13 49.9 0.7 7.3e-13 48.6 0.7 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 CDW54949.1 - 0.0091 15.6 0.1 0.36 10.4 0.0 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Sulfate_transp PF00916.20 CDW54950.1 - 6.1e-70 235.9 19.6 2.8e-41 141.5 0.4 3.8 2 1 2 4 4 4 3 Sulfate permease family STAS PF01740.21 CDW54950.1 - 2.8e-22 78.6 0.0 4.9e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 STAS domain Pkinase PF00069.25 CDW54951.1 - 4.3e-44 150.9 0.0 5.1e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54951.1 - 7.8e-44 149.9 0.0 2.8e-43 148.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Piwi PF02171.17 CDW54952.1 - 8.7e-114 379.8 0.0 1.3e-113 379.3 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 CDW54952.1 - 1.6e-34 118.0 0.2 5.6e-34 116.3 0.2 2.0 1 0 0 1 1 1 1 Mid domain of argonaute ArgoN PF16486.5 CDW54952.1 - 1.2e-28 100.4 0.0 2.8e-28 99.2 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 CDW54952.1 - 1.3e-27 96.3 0.3 2.1e-27 95.6 0.3 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 CDW54952.1 - 1.7e-23 82.0 0.2 3.6e-23 81.0 0.2 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 CDW54952.1 - 6e-14 52.1 0.0 1.5e-13 50.8 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain Sybindin PF04099.12 CDW54953.1 - 2e-23 82.9 0.0 2.3e-23 82.7 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CDW54953.1 - 0.0016 18.6 0.1 0.0023 18.0 0.1 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Rhodanese PF00581.20 CDW54954.1 - 3.2e-09 37.3 0.0 4.8e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain betaPIX_CC PF16523.5 CDW54955.1 - 8.6e-20 70.4 0.6 8.6e-20 70.4 0.6 1.8 2 0 0 2 2 2 1 betaPIX coiled coil RhoGEF PF00621.20 CDW54955.1 - 1.4e-17 64.5 0.0 3.1e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.6 CDW54955.1 - 5.1e-16 58.3 0.0 1.3e-15 57.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW54955.1 - 7.9e-15 54.2 0.1 2.2e-14 52.8 0.1 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CDW54955.1 - 1.4e-13 50.3 0.0 4.6e-13 48.6 0.0 2.0 1 0 0 1 1 1 1 Variant SH3 domain TetR_C_13 PF16925.5 CDW54955.1 - 0.021 14.8 0.0 0.1 12.5 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Xlink PF00193.17 CDW54955.1 - 0.028 14.8 0.0 0.093 13.1 0.0 1.9 1 0 0 1 1 1 0 Extracellular link domain MtrB PF05440.12 CDW54955.1 - 0.09 13.2 0.1 10 6.6 0.0 2.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B Pkinase PF00069.25 CDW54956.1 - 4.3e-48 164.0 0.0 5.9e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54956.1 - 8.5e-32 110.4 0.0 1.2e-31 109.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW54956.1 - 1.2e-05 24.2 0.0 0.0016 17.3 0.0 2.1 1 1 1 2 2 2 2 Fungal protein kinase Kdo PF06293.14 CDW54956.1 - 0.027 13.8 0.0 0.045 13.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DS PF01916.17 CDW54957.1 - 3.6e-126 420.3 0.0 4.2e-126 420.1 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase CLP1_P PF16575.5 CDW54958.1 - 0.00062 19.6 0.0 0.003 17.4 0.0 2.0 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ATPase PF06745.13 CDW54958.1 - 0.01 15.2 0.0 0.014 14.7 0.0 1.1 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 CDW54958.1 - 0.023 14.6 0.1 0.035 14.0 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CDW54958.1 - 0.028 14.7 0.0 0.046 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDW54958.1 - 0.036 14.4 0.0 0.059 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 CDW54958.1 - 0.083 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 CDW54958.1 - 0.12 12.5 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDW54958.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain LIM PF00412.22 CDW54959.1 - 3e-22 78.6 29.4 2.8e-12 46.7 9.6 2.4 2 0 0 2 2 2 2 LIM domain zf-HYPF PF07503.12 CDW54959.1 - 0.047 13.5 2.2 0.047 13.5 2.2 4.0 4 1 0 4 4 4 0 HypF finger PI3_PI4_kinase PF00454.27 CDW54960.1 - 2.1e-36 126.0 0.4 5.9e-36 124.5 0.4 1.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 CDW54960.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) cobW PF02492.19 CDW54960.1 - 0.17 11.5 0.2 0.41 10.2 0.2 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain UCR_14kD PF02271.16 CDW54961.1 - 4.6e-25 87.5 2.6 5.6e-25 87.2 2.6 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Pkinase PF00069.25 CDW54962.1 - 6.4e-56 189.6 0.0 1.9e-55 188.1 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54962.1 - 1.1e-39 136.3 0.0 2.8e-39 135.0 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 CDW54962.1 - 1.6e-22 79.5 2.7 2.1e-19 69.5 1.5 3.1 2 0 0 2 2 2 2 Oxidative-stress-responsive kinase 1 C-terminal domain AAA_23 PF13476.6 CDW54963.1 - 1e-16 62.1 0.0 1e-16 62.1 0.0 5.4 1 1 2 4 4 3 2 AAA domain SMC_N PF02463.19 CDW54963.1 - 1.3e-06 28.1 0.0 1.3e-06 28.1 0.0 2.6 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDW54963.1 - 6.5e-06 26.2 0.3 2.3e-05 24.4 0.3 2.0 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW54963.1 - 0.0001 22.0 0.0 0.0002 21.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CDW54963.1 - 0.0021 18.5 0.6 0.015 15.6 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain AAA_15 PF13175.6 CDW54963.1 - 0.0087 15.8 43.1 8.6e+02 -0.6 43.1 3.4 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 CDW54963.1 - 0.0095 16.5 0.1 0.0095 16.5 0.1 3.9 3 1 0 3 3 2 1 ABC transporter AAA PF00004.29 CDW54963.1 - 0.0098 16.3 0.0 0.073 13.5 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW54963.1 - 0.015 15.6 1.0 0.054 13.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_13 PF13166.6 CDW54963.1 - 0.09 11.4 50.6 0.0064 15.2 12.0 3.9 3 1 0 3 3 2 0 AAA domain MtrG PF04210.13 CDW54963.1 - 0.15 12.0 9.3 10 6.1 0.2 4.8 4 0 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G AAA_19 PF13245.6 CDW54963.1 - 0.52 10.6 0.1 0.52 10.6 0.1 3.5 2 1 0 2 2 1 0 AAA domain BLOC1_2 PF10046.9 CDW54963.1 - 0.73 10.2 41.8 0.04 14.2 4.2 6.2 4 3 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 CDW54963.1 - 0.96 9.5 30.2 0.066 13.2 1.6 5.2 3 2 2 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Golgin_A5 PF09787.9 CDW54963.1 - 1.2 8.5 55.0 9.5 5.6 20.9 3.7 1 1 1 2 2 2 0 Golgin subfamily A member 5 BRCA-2_OB3 PF09104.10 CDW54963.1 - 2.1 8.0 6.3 2 8.0 0.6 3.0 2 1 0 2 2 2 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 SMC_N PF02463.19 CDW54964.1 - 2.4e-08 33.7 1.9 3.4e-08 33.2 1.9 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CDW54964.1 - 0.00098 19.3 0.1 0.0024 18.1 0.1 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Nucleoporin_FG2 PF15967.5 CDW54964.1 - 0.064 11.8 3.1 0.095 11.2 3.1 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region T-box PF00907.22 CDW54965.1 - 9.3e-76 254.2 0.0 1.6e-75 253.4 0.0 1.4 1 0 0 1 1 1 1 T-box RRM_1 PF00076.22 CDW54966.1 - 3.8e-37 125.9 0.3 1.9e-12 46.8 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hnRNP_Q_AcD PF18360.1 CDW54966.1 - 1.6e-16 60.0 0.1 9.8e-16 57.5 0.0 2.2 2 0 0 2 2 2 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain RRM_5 PF13893.6 CDW54966.1 - 1.2e-05 24.9 0.0 0.00035 20.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW54966.1 - 0.00058 19.7 0.0 1.5 8.7 0.0 2.9 3 0 0 3 3 3 2 Occluded RNA-recognition motif RNA_bind PF08675.11 CDW54966.1 - 0.0038 17.2 0.0 0.092 12.8 0.0 2.9 3 0 0 3 3 3 1 RNA binding domain RRM_7 PF16367.5 CDW54966.1 - 0.0086 16.2 0.5 17 5.6 0.0 3.7 3 2 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.6 CDW54966.1 - 0.088 13.0 0.2 8 6.7 0.0 3.3 4 0 0 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter Ricin_B_lectin PF00652.22 CDW54968.1 - 1.8e-28 99.3 0.4 2.8e-28 98.7 0.4 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glycos_transf_2 PF00535.26 CDW54968.1 - 7.4e-28 97.5 0.0 1.2e-27 96.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 CDW54968.1 - 6.5e-06 25.7 0.1 1.9e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 CDW54968.1 - 0.003 18.3 0.0 0.89 10.3 0.0 2.6 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like Actin PF00022.19 CDW54971.1 - 5.8e-98 328.2 0.0 7.1e-98 327.9 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CDW54971.1 - 2.2e-05 23.5 0.0 0.046 12.5 0.0 2.4 2 1 0 2 2 2 2 MreB/Mbl protein PA28_beta PF02252.18 CDW54972.1 - 1.7e-56 189.9 0.4 3e-56 189.1 0.2 1.4 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 CDW54972.1 - 5.9e-12 45.4 0.0 1.4e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit AA_permease PF00324.21 CDW54973.1 - 4.3e-66 223.5 27.6 6.9e-47 160.1 1.3 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 CDW54973.1 - 5.6e-34 117.9 1.1 7.6e-27 94.4 0.2 2.1 1 1 1 2 2 2 2 Solute carrier family 12 DUF1794 PF08768.11 CDW54974.1 - 5.9e-27 94.4 0.0 7.1e-27 94.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) ShK PF01549.24 CDW54974.1 - 0.00022 21.7 9.7 0.00032 21.2 9.7 1.3 1 0 0 1 1 1 1 ShK domain-like PLDc_3 PF13918.6 CDW54975.1 - 4e-26 91.7 0.1 7.5e-26 90.8 0.1 1.5 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 CDW54975.1 - 1.5e-25 89.7 0.3 7.9e-12 45.2 0.6 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CDW54975.1 - 3.9e-11 42.6 1.1 3.5e-08 33.3 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif SMN PF06003.12 CDW54977.1 - 0.0017 17.6 5.1 0.0026 17.1 1.2 2.2 1 1 0 2 2 2 2 Survival motor neuron protein (SMN) DDE_Tnp_1_6 PF13751.6 CDW54978.1 - 1 9.6 5.6 0.38 11.0 2.4 1.9 2 0 0 2 2 2 0 Transposase DDE domain Snf7 PF03357.21 CDW54979.1 - 6.2e-42 143.1 25.4 9e-42 142.6 25.4 1.2 1 0 0 1 1 1 1 Snf7 5_nucleotid_C PF02872.18 CDW54980.1 - 1.4e-37 129.3 0.0 3.1e-37 128.2 0.0 1.6 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CDW54980.1 - 4.6e-09 37.1 0.0 7.5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ras PF00071.22 CDW54981.1 - 4.4e-66 221.5 0.2 5e-66 221.3 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW54981.1 - 1.7e-36 125.1 0.1 2.6e-36 124.4 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW54981.1 - 4.5e-18 65.3 0.4 5e-18 65.1 0.4 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW54981.1 - 4e-07 29.6 0.2 5e-07 29.3 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDW54981.1 - 5.1e-07 29.3 0.1 6.3e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDW54981.1 - 3.4e-05 23.5 0.2 6.7e-05 22.5 0.1 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW54981.1 - 8.1e-05 22.7 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW54981.1 - 0.0038 17.2 0.2 1.4 8.8 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase AAA PF00004.29 CDW54981.1 - 0.012 16.0 0.1 0.019 15.4 0.1 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 CDW54981.1 - 0.013 14.8 0.0 0.029 13.7 0.0 1.5 1 0 0 1 1 1 0 Septin TniB PF05621.11 CDW54981.1 - 0.025 14.0 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 CDW54981.1 - 0.032 13.8 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 CDW54981.1 - 0.18 12.2 0.0 0.22 11.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain Jiraiya PF15038.6 CDW54982.1 - 0.00021 20.8 4.2 0.00072 19.0 4.2 1.8 1 1 0 1 1 1 1 Jiraiya XK-related PF09815.9 CDW54982.1 - 0.02 14.0 0.5 0.038 13.0 0.5 1.4 1 1 0 1 1 1 0 XK-related protein Guanylate_cyc PF00211.20 CDW54983.1 - 2.9e-64 216.1 0.0 5.1e-64 215.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 CDW54983.1 - 2e-40 139.0 1.5 3.3e-40 138.3 1.5 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.17 CDW54983.1 - 5.5e-33 114.3 0.0 9.2e-33 113.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW54983.1 - 1.3e-27 96.8 0.0 3.1e-27 95.6 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 CDW54983.1 - 7.2e-06 25.6 2.0 1.4e-05 24.7 2.0 1.4 1 0 0 1 1 1 1 Heme NO binding associated Kinase-like PF14531.6 CDW54983.1 - 0.0074 15.6 0.1 0.4 9.9 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Luteo_PO PF04662.13 CDW54984.1 - 0.02 14.6 0.1 0.055 13.1 0.0 1.7 2 0 0 2 2 2 0 Luteovirus P0 protein Glyco_transf_22 PF03901.17 CDW54985.1 - 1e-80 272.1 35.2 1.2e-80 271.8 35.2 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family TED_complement PF07678.14 CDW54985.1 - 0.14 11.1 0.5 0.26 10.3 0.1 1.6 2 0 0 2 2 2 0 A-macroglobulin TED domain DUF4231 PF14015.6 CDW54985.1 - 0.18 12.3 1.8 1.1 9.8 0.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Phosphodiest PF01663.22 CDW54986.1 - 3.3e-13 50.0 2.0 1e-07 31.9 0.6 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CDW54986.1 - 0.0035 16.8 0.1 0.1 12.0 0.1 2.2 2 0 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 CDW54986.1 - 0.17 11.3 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Metalloenzyme superfamily Globin PF00042.22 CDW54987.1 - 3e-15 56.7 0.0 4.5e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Globin DUF4071 PF13281.6 CDW54988.1 - 5.4e-134 446.9 0.7 9.4e-134 446.1 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4071) Pkinase PF00069.25 CDW54988.1 - 4.4e-61 206.5 0.0 7.8e-61 205.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW54988.1 - 1.3e-45 155.8 0.0 2.5e-45 154.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW54988.1 - 0.00042 19.2 0.0 0.0015 17.4 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase SAM_KSR1 PF13543.6 CDW54988.1 - 0.0039 17.3 0.2 0.013 15.6 0.2 1.9 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 DUF4756 PF15948.5 CDW54988.1 - 0.015 15.1 0.1 0.037 13.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4756) TPR_8 PF13181.6 CDW54988.1 - 0.16 12.3 0.5 1.1 9.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Methyltr_RsmB-F PF01189.17 CDW54989.1 - 8.7e-37 126.7 0.0 3.1e-36 124.9 0.0 1.8 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 CDW54989.1 - 4.8e-05 23.6 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF2431 PF10354.9 CDW54989.1 - 0.07 13.4 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) cwf18 PF08315.12 CDW54990.1 - 7.9e-29 101.0 5.3 9.9e-29 100.7 5.3 1.1 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor SIR4_SID PF16991.5 CDW54990.1 - 0.098 12.7 3.4 0.24 11.4 3.3 1.7 1 1 0 1 1 1 0 Sir4 SID domain CNOT1_HEAT PF16418.5 CDW54990.1 - 0.15 12.2 1.4 0.17 12.0 1.2 1.3 1 1 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Trp_oprn_chp PF09534.10 CDW54991.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ig_3 PF13927.6 CDW54992.1 - 0.0023 18.5 0.0 0.0025 18.4 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 CDW54992.1 - 0.0028 17.8 0.0 0.0029 17.7 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 CDW54992.1 - 0.0067 16.6 0.0 0.0073 16.5 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 CDW54992.1 - 0.042 14.2 0.0 0.047 14.0 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain DB PF01682.19 CDW54993.1 - 1.9e-24 85.8 28.3 1.8e-12 47.4 11.6 2.5 2 1 0 2 2 2 2 DB module fn3 PF00041.21 CDW54993.1 - 5.8e-13 49.0 1.1 1.4e-08 35.0 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain I-set PF07679.16 CDW54993.1 - 0.00031 20.8 0.0 0.00077 19.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 CDW54993.1 - 0.0032 18.0 0.0 0.57 10.8 0.0 2.7 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ig_3 PF13927.6 CDW54993.1 - 0.0048 17.5 0.1 0.02 15.5 0.0 2.1 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 CDW54993.1 - 0.0094 16.1 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin V-set domain ig PF00047.25 CDW54993.1 - 0.013 15.7 0.1 0.07 13.3 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain Interfer-bind PF09294.10 CDW54993.1 - 0.032 14.5 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III DUF4992 PF16383.5 CDW54993.1 - 0.21 11.1 0.0 0.34 10.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function Ig_3 PF13927.6 CDW54994.1 - 2.7e-45 152.8 1.3 1.9e-15 57.2 0.1 4.9 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 CDW54994.1 - 5.5e-40 135.3 0.1 1.7e-13 50.4 0.0 5.1 4 1 0 4 4 4 3 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW54994.1 - 7.3e-31 106.3 0.9 2.6e-11 43.7 0.2 4.5 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 CDW54994.1 - 1.2e-24 86.3 0.8 7.1e-08 32.5 0.0 4.8 4 1 0 4 4 4 3 Immunoglobulin domain fn3 PF00041.21 CDW54994.1 - 7.1e-16 58.3 3.1 5.6e-09 36.2 0.3 3.0 2 1 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 CDW54994.1 - 1.4e-13 50.9 5.5 0.009 16.2 0.0 7.6 5 3 1 6 6 6 3 Immunoglobulin V-set domain Ig_4 PF16680.5 CDW54994.1 - 6.3e-09 36.0 0.2 0.19 12.0 0.0 4.9 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 CDW54994.1 - 2.8e-08 33.7 0.0 0.0012 18.8 0.0 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 CDW54994.1 - 4.6e-08 33.4 0.1 0.0097 16.3 0.0 4.0 4 0 0 4 4 3 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 CDW54994.1 - 1.5e-07 30.8 0.3 0.021 14.4 0.0 4.7 5 0 0 5 5 5 2 Immunoglobulin domain Tissue_fac PF01108.17 CDW54994.1 - 2.5e-06 27.3 0.5 0.0023 17.8 0.0 2.7 3 0 0 3 3 3 2 Tissue factor Pur_ac_phosph_N PF16656.5 CDW54994.1 - 5.4e-05 23.7 1.0 0.13 12.9 0.2 3.2 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Izumo-Ig PF16706.5 CDW54994.1 - 0.00049 20.1 0.0 15 5.8 0.0 4.3 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain C2-set PF05790.15 CDW54994.1 - 0.028 14.6 0.1 34 4.7 0.0 3.7 4 0 0 4 4 4 0 Immunoglobulin C2-set domain Herpes_gE PF02480.16 CDW54994.1 - 0.051 12.3 0.0 21 3.7 0.0 3.5 3 1 0 3 3 3 0 Alphaherpesvirus glycoprotein E Ig_C17orf99 PF17736.1 CDW54994.1 - 0.065 13.3 0.5 64 3.7 0.0 3.9 4 0 0 4 4 4 0 C17orf99 Ig domain DUF4999 PF16390.5 CDW54994.1 - 0.1 12.8 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Glyco_hydro_18 PF00704.28 CDW54995.1 - 1.6e-89 300.8 7.5 1.9e-89 300.5 7.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_14 PF01607.24 CDW54995.1 - 1.9e-15 56.7 7.7 4.1e-15 55.7 7.7 1.6 1 0 0 1 1 1 1 Chitin binding Peritrophin-A domain RRP7 PF12923.7 CDW54996.1 - 7.4e-28 97.1 12.9 1e-27 96.6 12.9 1.1 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_1 PF00076.22 CDW54996.1 - 0.00018 21.3 1.9 0.00037 20.3 0.1 2.4 2 2 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW54996.1 - 0.011 15.8 0.6 0.18 11.9 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 CDW54996.1 - 0.67 10.2 12.0 18 5.5 0.0 2.8 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter CENP-H PF05837.12 CDW54996.1 - 1.5 9.3 10.7 2.1 8.8 10.0 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) TFIID-31kDa PF02291.15 CDW54997.1 - 5.6e-18 65.2 0.4 1.1e-17 64.2 0.1 1.5 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 CDW54997.1 - 9.2e-05 22.8 0.0 0.00021 21.6 0.0 1.6 1 0 0 1 1 1 1 CENP-S protein Med23 PF11573.8 CDW54998.1 - 9.8e-46 156.1 2.9 1.1e-45 155.9 2.9 1.0 1 0 0 1 1 1 1 Mediator complex subunit 23 Phage_antitermQ PF06530.12 CDW54998.1 - 0.094 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q Biopterin_H PF00351.21 CDW54999.1 - 1.9e-165 549.8 0.1 2.4e-165 549.5 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 CDW54999.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 ACT domain ATP-synt_DE_N PF02823.16 CDW55000.1 - 6.7e-17 61.2 0.1 9.3e-17 60.7 0.1 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain eIF-5a PF01287.20 CDW55000.1 - 0.082 13.0 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold DUF3489 PF11994.8 CDW55000.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3489) NCD2 PF04905.13 CDW55001.1 - 1.6e-52 176.8 0.0 2.6e-52 176.0 0.0 1.4 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) NCD1 PF04904.13 CDW55001.1 - 2e-42 143.0 0.1 4e-42 142.1 0.1 1.5 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) SAM_1 PF00536.30 CDW55001.1 - 0.023 15.1 0.1 0.043 14.3 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF4355 PF14265.6 CDW55002.1 - 0.15 12.3 3.0 0.2 11.9 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) DivIC PF04977.15 CDW55002.1 - 1.9 8.3 5.7 2.2 8.1 3.6 2.0 1 1 1 2 2 2 0 Septum formation initiator TAP42 PF04177.12 CDW55003.1 - 1.1e-06 28.0 0.1 1.2e-06 27.9 0.1 1.1 1 0 0 1 1 1 1 TAP42-like family Histone_H2A_C PF16211.5 CDW55004.1 - 3.7e-18 65.0 0.1 7.9e-18 63.9 0.1 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW55004.1 - 5.1e-16 59.2 0.0 6.8e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW55004.1 - 2e-05 24.8 0.0 2.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pkinase PF00069.25 CDW55005.1 - 2.7e-24 86.0 0.0 4.1e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55005.1 - 3.3e-13 49.5 0.0 6.1e-13 48.6 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW55005.1 - 0.00043 19.2 0.0 0.00059 18.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Ion_trans PF00520.31 CDW55006.1 - 1.8e-45 155.1 15.8 2.3e-45 154.7 15.8 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 CDW55006.1 - 1.1e-27 96.2 0.1 2.7e-27 95.0 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 CDW55006.1 - 5e-13 48.8 5.1 5e-13 48.8 5.1 2.7 3 0 0 3 3 3 1 Ion channel BTB_3 PF16017.5 CDW55006.1 - 0.0015 18.6 0.2 0.0065 16.6 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain PKD_channel PF08016.12 CDW55006.1 - 0.037 12.7 11.3 0.0096 14.6 1.9 2.3 1 1 1 2 2 2 0 Polycystin cation channel Collagen PF01391.18 CDW55007.1 - 0.016 14.9 9.2 0.032 14.0 9.2 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Pkinase_Tyr PF07714.17 CDW55008.1 - 4.3e-67 226.1 0.0 5.5e-67 225.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW55008.1 - 2.1e-39 135.5 0.0 2.9e-39 135.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDW55008.1 - 0.0001 21.8 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like SH2 PF00017.24 CDW55008.1 - 0.00022 21.3 0.0 0.00044 20.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 CDW55008.1 - 0.034 14.1 0.1 10 6.0 0.0 2.5 1 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW55008.1 - 0.047 12.5 0.0 0.089 11.5 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PNP_UDP_1 PF01048.20 CDW55009.1 - 3.6e-24 85.3 0.0 4.4e-24 85.0 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily ATP-synt_8 PF00895.20 CDW55010.1 - 0.032 14.7 2.0 0.044 14.2 0.1 2.2 2 0 0 2 2 2 0 ATP synthase protein 8 Zip PF02535.22 CDW55010.1 - 0.06 12.6 5.0 0.16 11.1 5.0 1.7 1 1 0 1 1 1 0 ZIP Zinc transporter MAP17 PF15807.5 CDW55010.1 - 0.89 9.8 5.7 1.8 8.8 0.1 2.3 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4834 PF16118.5 CDW55010.1 - 5.8 7.9 10.4 38 5.3 7.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Metallophos PF00149.28 CDW55011.1 - 1.8e-34 120.1 0.0 2.2e-34 119.8 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDW55011.1 - 0.14 12.4 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 CDW55011.1 - 0.17 12.4 0.1 1.5 9.4 0.0 2.4 3 0 0 3 3 3 0 Serine-threonine protein phosphatase N-terminal domain ASF1_hist_chap PF04729.13 CDW55012.1 - 2.2e-46 157.6 0.0 3e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone WW PF00397.26 CDW55013.1 - 2.2e-08 34.0 0.3 4e-08 33.2 0.3 1.4 1 0 0 1 1 1 1 WW domain Glyco_hyd_101C PF17451.2 CDW55013.1 - 0.066 13.5 0.5 0.15 12.3 0.3 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain Tropomodulin PF03250.14 CDW55013.1 - 0.68 10.0 4.1 0.6 10.2 0.4 2.5 2 1 1 3 3 3 0 Tropomodulin ASD2 PF08687.11 CDW55014.1 - 5e-37 128.0 14.8 5.5e-37 127.9 14.8 1.0 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 DNA_repr_REX1B PF14966.6 CDW55014.1 - 0.011 16.4 1.0 0.038 14.6 0.6 2.1 1 1 0 1 1 1 0 DNA repair REX1-B phiKZ_IP PF12699.7 CDW55014.1 - 0.04 13.1 3.3 0.065 12.4 3.3 1.3 1 0 0 1 1 1 0 phiKZ-like phage internal head proteins MCD_N PF17408.2 CDW55014.1 - 0.054 13.6 1.3 0.11 12.7 1.0 1.7 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase N-terminal domain DUF615 PF04751.14 CDW55014.1 - 0.06 13.3 8.6 0.077 13.0 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF615) HTH_Tnp_Mu_1 PF02316.16 CDW55014.1 - 0.078 13.1 0.4 0.15 12.2 0.2 1.5 1 1 0 1 1 1 0 Mu DNA-binding domain ALIX_LYPXL_bnd PF13949.6 CDW55014.1 - 0.43 9.8 10.6 0.91 8.8 10.6 1.6 1 1 0 1 1 1 0 ALIX V-shaped domain binding to HIV KIP1 PF07765.12 CDW55014.1 - 3.3 7.9 9.6 1 9.6 1.1 2.6 2 1 1 3 3 3 0 KIP1-like protein Fib_alpha PF08702.10 CDW55014.1 - 4.9 7.3 9.6 2.1 8.5 6.7 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Lig_chan PF00060.26 CDW55015.1 - 4.5e-49 166.1 0.8 7.3e-49 165.4 0.8 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 CDW55015.1 - 3e-36 124.1 0.0 7.5e-36 122.8 0.0 1.7 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.28 CDW55015.1 - 1.3e-25 90.2 0.0 2.3e-25 89.5 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.20 CDW55015.1 - 6.1e-23 81.4 0.0 1.2e-22 80.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.16 CDW55015.1 - 3.1 7.8 6.2 50 4.0 0.0 3.8 4 0 0 4 4 4 0 Ion channel Pou PF00157.17 CDW55016.1 - 4.5e-30 103.4 0.0 8.6e-30 102.5 0.0 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 CDW55016.1 - 2.1e-17 62.7 2.0 3.8e-17 61.9 2.0 1.4 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 CDW55016.1 - 0.00085 19.6 0.1 0.04 14.3 0.0 2.9 4 0 0 4 4 4 1 Helix-turn-helix domain Homeobox_KN PF05920.11 CDW55016.1 - 0.061 13.2 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Homeobox KN domain zf-CpG_bind_C PF12269.8 CDW55017.1 - 3.4e-57 193.9 5.5 9.7e-57 192.4 5.5 1.8 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain PHD PF00628.29 CDW55017.1 - 1.6e-12 47.1 8.6 1.6e-12 47.1 8.6 5.2 6 2 0 6 6 6 1 PHD-finger zf-CXXC PF02008.20 CDW55017.1 - 8e-08 32.2 35.9 0.0002 21.3 8.1 3.7 3 0 0 3 3 3 2 CXXC zinc finger domain T6SS_VipA PF05591.12 CDW55018.1 - 0.017 14.9 0.9 0.031 14.1 0.9 1.4 1 0 0 1 1 1 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 AvrPtoB-E3_ubiq PF09046.10 CDW55018.1 - 0.056 13.7 0.0 0.091 13.0 0.0 1.4 1 1 0 1 1 1 0 AvrPtoB E3 ubiquitin ligase Geminin PF07412.12 CDW55018.1 - 0.074 12.8 5.0 0.034 13.9 1.9 1.8 1 1 1 2 2 2 0 Geminin ANAPC4_WD40 PF12894.7 CDW55019.1 - 2.4e-08 34.2 1.9 0.019 15.2 0.0 4.9 6 0 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain DUF2358 PF10184.9 CDW55019.1 - 0.032 14.5 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) Gln-synt_N_2 PF16952.5 CDW55019.1 - 0.14 12.0 0.0 0.47 10.3 0.0 1.9 1 0 0 1 1 1 0 Glutamine synthetase N-terminal domain PQQ_3 PF13570.6 CDW55019.1 - 0.3 11.6 2.1 0.95 10.0 0.0 3.1 5 0 0 5 5 5 0 PQQ-like domain WD40 PF00400.32 CDW55019.1 - 0.42 11.6 11.6 4.5 8.3 0.5 5.3 5 0 0 5 5 5 0 WD domain, G-beta repeat UDPGT PF00201.18 CDW55020.1 - 7.5e-35 120.7 0.5 1.9e-34 119.3 0.3 1.6 1 1 1 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW55020.1 - 3.5e-06 27.1 0.0 6.6e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 CDW55021.1 - 3e-83 280.3 0.3 1.3e-44 152.8 0.2 2.4 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW55021.1 - 4.1e-07 30.1 0.0 0.0055 16.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase family 28 C-terminal domain TP_methylase PF00590.20 CDW55021.1 - 0.11 12.5 0.0 16 5.4 0.0 2.3 2 0 0 2 2 2 0 Tetrapyrrole (Corrin/Porphyrin) Methylases Alpha_adaptinC2 PF02883.20 CDW55021.1 - 0.12 12.7 0.1 18 5.7 0.0 2.5 2 0 0 2 2 2 0 Adaptin C-terminal domain UDPGT PF00201.18 CDW55022.1 - 1.6e-37 129.5 0.0 1.4e-36 126.4 0.0 1.9 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW55022.1 - 0.0027 17.7 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Thioredoxin_4 PF13462.6 CDW55022.1 - 0.12 12.5 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin UDPGT PF00201.18 CDW55023.1 - 3.7e-39 134.9 0.1 6.7e-39 134.0 0.1 1.4 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW55023.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 CDW55024.1 - 1.9e-30 106.1 0.0 2.3e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW55024.1 - 0.012 15.6 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 CDW55025.1 - 1.5e-45 156.0 0.6 2.2e-45 155.4 0.6 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW55025.1 - 0.0024 17.9 0.0 0.0058 16.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_28 PF03033.20 CDW55025.1 - 0.17 11.9 0.0 0.46 10.5 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain CtsR PF05848.11 CDW55026.1 - 0.057 13.4 0.7 0.2 11.6 0.1 2.0 1 1 1 2 2 2 0 CtsR N-terminal HTH domain DnaI_N PF07319.11 CDW55027.1 - 0.068 13.8 0.1 0.12 13.1 0.1 1.3 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus UDPGT PF00201.18 CDW55029.1 - 2.8e-34 118.8 0.0 7.7e-34 117.3 0.0 1.6 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW55029.1 - 2.7e-05 24.2 0.0 4.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain zf-ANAPC11 PF12861.7 CDW55030.1 - 2.5e-07 30.6 5.6 4.2e-07 29.9 5.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CDW55030.1 - 3.9e-07 30.3 12.9 6.8e-07 29.5 12.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CDW55030.1 - 1.8e-06 28.1 11.8 3.5e-06 27.2 11.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDW55030.1 - 3.5e-05 23.6 13.9 6.3e-05 22.8 13.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDW55030.1 - 5.4e-05 23.3 10.6 0.00019 21.5 10.6 1.8 1 1 0 1 1 1 1 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CDW55030.1 - 0.0061 16.2 10.8 0.023 14.3 10.8 1.8 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 CDW55030.1 - 0.032 14.5 8.3 0.032 14.5 8.3 1.7 2 0 0 2 2 1 0 RING-like domain RINGv PF12906.7 CDW55030.1 - 0.058 13.5 10.5 0.12 12.6 10.5 1.5 1 1 0 1 1 1 0 RING-variant domain zf-RING_9 PF13901.6 CDW55030.1 - 0.16 11.9 8.6 0.24 11.4 8.6 1.1 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-C3HC4_2 PF13923.6 CDW55030.1 - 0.25 11.2 17.5 1.5 8.7 17.5 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CDW55030.1 - 0.56 10.1 8.6 1.2 9.0 8.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 CDW55030.1 - 0.8 9.6 9.8 1.5 8.8 9.8 1.5 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 CDW55030.1 - 1.4 8.9 12.2 0.2 11.5 7.3 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_11 PF17123.5 CDW55030.1 - 2.1 8.2 12.3 20 5.0 12.3 2.2 1 1 0 1 1 1 0 RING-like zinc finger CAP PF00188.26 CDW55031.1 - 5.3e-06 27.3 2.8 2.7e-05 25.0 2.8 1.9 1 1 0 1 1 1 1 Cysteine-rich secretory protein family CH PF00307.31 CDW55033.1 - 2.9e-23 82.1 0.0 3.4e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 CDW55033.1 - 1.5e-07 31.2 0.0 2.2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain CH_2 PF06294.11 CDW55033.1 - 0.04 14.0 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 CH-like domain in sperm protein Sugar_tr PF00083.24 CDW55034.1 - 2.7e-117 392.4 20.6 4.2e-117 391.8 20.6 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW55034.1 - 1.3e-24 86.8 29.5 1.3e-24 86.8 29.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily EMC3_TMCO1 PF01956.16 CDW55034.1 - 3.3 7.4 10.6 0.17 11.6 3.2 2.6 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like CK_II_beta PF01214.18 CDW55035.1 - 1.1e-78 263.3 0.3 2.1e-48 164.6 0.0 2.0 1 1 1 2 2 2 2 Casein kinase II regulatory subunit DUF3027 PF11228.8 CDW55035.1 - 0.19 11.7 0.0 0.27 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3027) FH2 PF02181.23 CDW55036.1 - 5.4e-74 249.5 0.1 8.2e-74 249.0 0.1 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain PRIMA1 PF16101.5 CDW55036.1 - 0.011 15.8 11.2 0.011 15.8 11.2 2.8 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Somatomedin_B PF01033.17 CDW55037.1 - 3.1e-08 33.9 4.4 3.1e-08 33.9 4.4 4.5 5 1 0 5 5 5 1 Somatomedin B domain TSP_1 PF00090.19 CDW55037.1 - 0.0073 16.5 11.2 0.023 14.9 0.9 3.1 2 0 0 2 2 2 2 Thrombospondin type 1 domain Orexin PF02072.15 CDW55037.1 - 0.4 10.6 6.0 0.54 10.2 0.2 2.3 2 0 0 2 2 2 0 Prepro-orexin TUDOR PF00567.24 CDW55038.1 - 3.8e-08 33.4 0.0 9.1e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 Tudor domain Glyco_hydro_cc PF11790.8 CDW55038.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase catalytic core PAN_1 PF00024.26 CDW55039.1 - 9.1e-15 54.4 18.0 0.00098 19.0 0.3 4.3 4 0 0 4 4 4 4 PAN domain YABBY PF04690.13 CDW55040.1 - 1.2 9.7 6.1 19 5.7 6.1 2.2 1 1 0 1 1 1 0 YABBY protein Endostatin PF06482.11 CDW55041.1 - 3.7e-36 125.2 0.2 4.8e-36 124.8 0.2 1.1 1 0 0 1 1 1 1 Collagenase NC10 and Endostatin Endostatin PF06482.11 CDW55042.1 - 2.1e-37 129.3 0.0 2.4e-35 122.5 0.0 2.1 1 1 0 1 1 1 1 Collagenase NC10 and Endostatin Collagen PF01391.18 CDW55042.1 - 2e-20 72.3 120.5 0.00037 20.2 46.6 5.4 3 2 2 5 5 5 5 Collagen triple helix repeat (20 copies) Laminin_G_3 PF13385.6 CDW55044.1 - 0.017 15.3 0.0 0.021 15.0 0.0 1.2 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily fn3 PF00041.21 CDW55046.1 - 4.3e-28 97.5 0.6 1.3e-12 47.8 0.1 4.3 4 0 0 4 4 4 3 Fibronectin type III domain MAM PF00629.23 CDW55046.1 - 2.4e-15 56.8 0.2 8.1e-15 55.1 0.0 2.0 2 1 0 2 2 2 1 MAM domain, meprin/A5/mu Pur_ac_phosph_N PF16656.5 CDW55046.1 - 7.8e-08 32.8 0.8 0.0078 16.8 0.1 3.8 3 1 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Ig_3 PF13927.6 CDW55046.1 - 2.1e-05 25.0 0.0 0.00021 21.8 0.0 2.7 3 0 0 3 3 3 1 Immunoglobulin domain MccV PF17508.2 CDW55046.1 - 0.0058 17.2 0.1 1.3 9.7 0.0 2.7 2 0 0 2 2 2 1 Microcin V bacteriocin DUF2369 PF10179.9 CDW55046.1 - 0.006 16.9 0.0 0.68 10.3 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) V-set PF07686.17 CDW55046.1 - 0.025 14.8 0.0 0.075 13.2 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin V-set domain Trypsin PF00089.26 CDW55047.1 - 6.7e-39 134.0 0.0 8.4e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW55047.1 - 2.9e-05 25.0 0.0 3.9e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW55047.1 - 0.024 15.0 0.0 0.051 14.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Syntaxin_2 PF14523.6 CDW55048.1 - 8.8e-29 99.9 8.9 8.8e-29 99.9 8.9 2.2 2 0 0 2 2 2 1 Syntaxin-like protein Syntaxin PF00804.25 CDW55048.1 - 3e-09 36.9 18.3 4.3e-08 33.1 18.3 2.2 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 CDW55048.1 - 2.1e-06 27.6 1.7 2.1e-06 27.6 1.7 2.0 2 0 0 2 2 2 1 SNARE domain T3SS_needle_E PF08988.10 CDW55048.1 - 0.048 13.8 0.2 0.048 13.8 0.2 3.8 4 1 1 5 5 5 0 Type III secretion system, cytoplasmic E component of needle DNA_repr_REX1B PF14966.6 CDW55048.1 - 0.095 13.4 0.9 0.095 13.4 0.9 2.6 3 1 0 3 3 3 0 DNA repair REX1-B DUF4988 PF16378.5 CDW55048.1 - 0.12 12.1 5.0 0.16 11.6 0.7 2.3 2 1 0 2 2 2 0 Domain of unknown function DUF2730 PF10805.8 CDW55048.1 - 0.58 10.3 7.2 0.097 12.8 1.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF16 PF01519.16 CDW55048.1 - 1.3 9.6 11.7 7.8 7.1 3.7 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 FUSC PF04632.12 CDW55048.1 - 7.3 5.0 7.9 1.3 7.5 4.6 1.4 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF1664 PF07889.12 CDW55048.1 - 8.4 6.5 11.9 3.8 7.6 0.3 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) Globin PF00042.22 CDW55049.1 - 0.022 15.3 0.0 0.042 14.4 0.0 1.5 1 1 0 1 1 1 0 Globin DUF4071 PF13281.6 CDW55050.1 - 1.2e-124 416.2 11.2 3.9e-119 398.0 1.7 4.2 2 1 1 3 3 3 2 Domain of unknown function (DUF4071) Pkinase PF00069.25 CDW55050.1 - 3.2e-62 210.3 0.0 5.7e-62 209.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55050.1 - 1.1e-45 156.0 0.0 2.2e-45 155.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW55050.1 - 0.0036 16.1 0.0 0.008 15.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDW55050.1 - 0.029 13.7 0.0 0.062 12.6 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Glutaredoxin PF00462.24 CDW55050.1 - 0.056 13.7 2.1 1.8 8.8 0.0 3.7 4 0 0 4 4 4 0 Glutaredoxin APH PF01636.23 CDW55050.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF836 PF05768.14 CDW55050.1 - 0.64 10.5 4.3 86 3.7 0.5 4.2 3 0 0 3 3 3 0 Glutaredoxin-like domain (DUF836) Glyco_hydro_38N PF01074.22 CDW55051.1 - 2.5e-90 302.8 2.5 3.4e-90 302.3 2.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 CDW55051.1 - 8.9e-18 64.2 0.0 1.9e-17 63.2 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 CDW55051.1 - 8.3e-12 45.6 0.0 1.4e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain WAC_Acf1_DNA_bd PF10537.9 CDW55051.1 - 0.035 14.6 0.4 0.099 13.2 0.4 1.7 1 0 0 1 1 1 0 ATP-utilising chromatin assembly and remodelling N-terminal Cas9_a PF18470.1 CDW55051.1 - 0.54 9.8 1.4 1.7 8.1 0.2 2.0 2 0 0 2 2 2 0 Cas9 alpha-helical lobe domain RIBIOP_C PF04950.12 CDW55052.1 - 1.5e-89 300.3 0.0 1.5e-89 300.3 0.0 2.5 3 0 0 3 3 3 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CDW55052.1 - 5.3e-26 90.5 0.1 3.5e-24 84.7 0.0 2.8 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 CDW55052.1 - 0.00019 21.0 0.1 0.0012 18.4 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW55052.1 - 0.0046 17.0 0.1 0.026 14.6 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CDW55052.1 - 0.058 13.8 0.0 0.2 12.0 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Actin PF00022.19 CDW55053.1 - 7.1e-87 291.7 0.0 7.1e-84 281.8 0.0 2.1 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CDW55053.1 - 7.2e-06 25.0 0.0 0.0033 16.3 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein Sulfolobus_pRN PF05584.11 CDW55053.1 - 0.079 13.0 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein Tetraspanin PF00335.20 CDW55054.1 - 9.9e-34 117.0 8.8 1.2e-33 116.7 8.8 1.0 1 0 0 1 1 1 1 Tetraspanin family MARVEL PF01284.23 CDW55054.1 - 0.0036 17.3 7.1 0.0049 16.9 7.1 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF3784 PF12650.7 CDW55054.1 - 0.073 13.3 8.4 0.14 12.3 8.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) DUF373 PF04123.13 CDW55054.1 - 0.34 10.3 4.6 0.55 9.6 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF2070 PF09843.9 CDW55054.1 - 0.36 9.1 8.4 0.46 8.7 8.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Saf_2TM PF18303.1 CDW55054.1 - 2.7 7.5 7.3 3.7 7.1 1.7 2.2 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain VWA_N2 PF16164.5 CDW55055.1 - 0.66 10.2 7.0 1.1 9.5 0.7 2.6 1 1 1 2 2 2 0 VWA N-terminal PseudoU_synth_1 PF01416.20 CDW55056.1 - 2.7e-26 92.2 0.2 1.4e-22 80.2 0.0 2.8 2 1 0 2 2 2 2 tRNA pseudouridine synthase Tmemb_9 PF05434.11 CDW55057.1 - 5.2e-44 149.6 4.6 6.2e-44 149.4 4.6 1.0 1 0 0 1 1 1 1 TMEM9 Shisa PF13908.6 CDW55057.1 - 0.0055 17.0 0.6 0.0071 16.6 0.6 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Gemini_mov PF01708.16 CDW55057.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 Geminivirus putative movement protein DUF4736 PF15883.5 CDW55057.1 - 0.38 10.5 4.3 0.64 9.7 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) TTR-52 PF01060.23 CDW55058.1 - 3.8e-07 30.7 0.0 6.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Transthyretin-like family Adaptin_N PF01602.20 CDW55059.1 - 3.9e-108 362.3 12.6 6.5e-108 361.6 12.6 1.3 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 CDW55059.1 - 8.4e-35 120.1 0.0 1.9e-34 119.0 0.0 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 CDW55059.1 - 1.6e-28 99.1 0.0 4.6e-28 97.7 0.0 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 CDW55059.1 - 1.6e-14 54.0 9.5 7.5e-08 32.7 0.0 6.1 3 2 4 7 7 7 2 HEAT repeats Cnd1 PF12717.7 CDW55059.1 - 4.7e-13 49.5 11.9 7.9e-07 29.3 0.9 4.1 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 CDW55059.1 - 4.1e-05 23.9 9.6 0.058 14.1 0.1 5.5 6 0 0 6 6 5 2 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 CDW55059.1 - 5.6e-05 23.5 8.9 0.0017 18.8 0.1 4.9 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.22 CDW55059.1 - 0.0038 17.4 15.5 12 6.4 0.1 7.9 7 0 0 7 7 7 1 HEAT repeat Vitellogenin_N PF01347.22 CDW55059.1 - 0.029 12.8 0.6 2.5 6.4 0.0 2.5 2 0 0 2 2 2 0 Lipoprotein amino terminal region Pox_D3 PF04580.13 CDW55059.1 - 0.078 12.6 0.5 0.2 11.2 0.5 1.6 1 0 0 1 1 1 0 Chordopoxvirinae D3 protein Cnd3 PF12719.7 CDW55059.1 - 0.11 11.7 3.8 1.8 7.7 0.1 3.5 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain Flavodoxin_1 PF00258.25 CDW55060.1 - 5.2e-29 101.3 0.0 9e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 CDW55060.1 - 7.5e-26 91.1 0.0 1.2e-25 90.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CDW55060.1 - 6.5e-10 39.6 0.0 1.3e-09 38.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.7 CDW55060.1 - 0.0033 17.1 0.1 0.0062 16.2 0.1 1.4 1 0 0 1 1 1 1 Flavodoxin domain TPP_enzyme_N PF02776.18 CDW55061.1 - 2.5e-45 154.2 0.3 6.7e-45 152.8 0.3 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CDW55061.1 - 2.6e-28 98.7 0.1 1.3e-26 93.2 0.1 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CDW55061.1 - 7.3e-15 54.9 0.0 3e-14 52.9 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CO_dh PF02552.16 CDW55061.1 - 0.14 12.0 0.0 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit wnt PF00110.19 CDW55062.1 - 4.3e-107 358.3 25.9 1.1e-106 356.9 25.9 1.6 1 1 0 1 1 1 1 wnt family ANF_receptor PF01094.28 CDW55063.1 - 1.3e-79 267.9 0.2 1.7e-79 267.5 0.2 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 CDW55063.1 - 3.5e-51 174.2 33.2 5.2e-51 173.7 33.2 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Peripla_BP_6 PF13458.6 CDW55063.1 - 2.3e-08 34.1 0.0 4e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein NCD3G PF07562.14 CDW55063.1 - 7.1e-05 22.7 6.9 0.00019 21.3 6.9 1.7 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peptidase_M14 PF00246.24 CDW55064.1 - 1.7e-68 231.6 0.0 2.1e-68 231.2 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 CDW55064.1 - 1.4e-11 44.5 0.0 2.2e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 CDW55064.1 - 0.0016 18.4 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 CDW55064.1 - 0.012 14.7 0.1 0.03 13.4 0.1 1.6 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family Nop14 PF04147.12 CDW55064.1 - 3.7 5.6 4.9 61 1.6 0.0 2.1 2 0 0 2 2 2 0 Nop14-like family PBP1_TM PF14812.6 CDW55064.1 - 7.1 7.1 10.6 15 6.0 10.6 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DB PF01682.19 CDW55065.1 - 1.3e-53 179.3 69.9 4.5e-15 55.8 11.9 4.8 4 0 0 4 4 4 4 DB module fn3 PF00041.21 CDW55065.1 - 4.4e-32 110.3 25.4 6.3e-09 36.1 1.0 6.4 6 0 0 6 6 6 6 Fibronectin type III domain Ig_3 PF13927.6 CDW55065.1 - 2.4e-18 66.5 3.8 9.1e-05 23.0 0.0 6.0 5 2 0 5 5 5 3 Immunoglobulin domain I-set PF07679.16 CDW55065.1 - 1.2e-15 57.3 0.3 1.1e-05 25.4 0.0 5.8 5 2 0 5 5 5 2 Immunoglobulin I-set domain ig PF00047.25 CDW55065.1 - 7.7e-12 45.2 6.1 7.1e-05 22.9 0.1 5.4 4 1 0 4 4 4 2 Immunoglobulin domain Interfer-bind PF09294.10 CDW55065.1 - 2.3e-09 37.5 6.0 0.024 14.9 0.0 5.1 5 0 0 5 5 5 2 Interferon-alpha/beta receptor, fibronectin type III V-set PF07686.17 CDW55065.1 - 5.7e-09 36.1 7.1 0.051 13.8 0.9 6.0 4 2 0 4 4 4 2 Immunoglobulin V-set domain Ig_2 PF13895.6 CDW55065.1 - 8e-09 35.7 8.1 0.0018 18.5 0.1 5.0 3 1 0 3 3 3 2 Immunoglobulin domain C1-set PF07654.15 CDW55065.1 - 0.0061 16.9 5.7 0.034 14.5 0.0 4.5 6 0 0 6 6 6 1 Immunoglobulin C1-set domain Ig_6 PF18452.1 CDW55065.1 - 0.011 15.3 0.3 2.6 7.7 0.1 2.7 2 0 0 2 2 2 0 Immunoglobulin domain PKD PF00801.20 CDW55065.1 - 0.04 13.7 1.6 4.1 7.3 0.0 4.3 3 1 1 4 4 4 0 PKD domain Izumo-Ig PF16706.5 CDW55065.1 - 0.092 12.8 0.8 0.83 9.8 0.1 2.9 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain DAG1 PF05454.11 CDW55066.1 - 2.8e-36 125.4 10.7 1.2e-35 123.3 10.7 1.8 1 1 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) He_PIG PF05345.12 CDW55066.1 - 0.0058 16.8 0.0 1 9.6 0.0 2.9 2 0 0 2 2 2 1 Putative Ig domain TMEM154 PF15102.6 CDW55066.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family DUF3247 PF11607.8 CDW55066.1 - 0.074 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3247) Mon1 PF03164.14 CDW55067.1 - 2.6e-121 405.5 0.6 3.3e-121 405.2 0.6 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Lactamase_B PF00753.27 CDW55068.1 - 1.7e-13 51.0 0.1 8.6e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDW55068.1 - 0.016 14.7 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DUF4729 PF15866.5 CDW55069.1 - 0.093 12.0 2.4 0.22 10.8 2.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4729) Sina PF03145.16 CDW55069.1 - 0.91 9.4 7.6 0.42 10.5 5.4 1.6 1 1 0 1 1 1 0 Seven in absentia protein family ECH_1 PF00378.20 CDW55070.1 - 1.2e-53 182.0 0.1 1.5e-53 181.7 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDW55070.1 - 2.4e-34 119.4 0.2 8.3e-31 107.7 0.1 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase SDH_sah PF01972.16 CDW55070.1 - 0.084 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Serine dehydrogenase proteinase Cohesin_load PF10345.9 CDW55071.1 - 2.4e-53 181.5 5.1 3.1e-53 181.2 5.1 1.1 1 0 0 1 1 1 1 Cohesin loading factor TPR_12 PF13424.6 CDW55071.1 - 6.3e-06 26.4 21.7 0.078 13.3 0.3 6.6 6 1 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55071.1 - 7.4e-05 22.7 11.3 2.7 8.4 0.1 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW55071.1 - 0.00045 20.7 2.0 0.022 15.3 0.1 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55071.1 - 0.0011 18.9 18.6 0.21 11.8 0.6 6.2 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDW55071.1 - 0.0086 16.8 7.7 21 6.3 0.3 5.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDW55071.1 - 0.08 12.6 2.3 0.17 11.6 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain ANAPC5 PF12862.7 CDW55071.1 - 0.097 12.7 11.6 0.25 11.5 0.4 4.7 4 3 0 4 4 4 0 Anaphase-promoting complex subunit 5 TPR_16 PF13432.6 CDW55071.1 - 0.12 13.0 0.2 0.12 13.0 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDW55071.1 - 0.49 10.3 9.2 5.6 7.0 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDW55071.1 - 8.3 6.4 21.4 2.1 8.3 0.2 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat NuA4 PF09340.10 CDW55072.1 - 4e-13 49.1 0.3 4e-13 49.1 0.3 1.6 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 zf-C2H2_6 PF13912.6 CDW55074.1 - 0.0017 18.3 0.2 0.0017 18.3 0.2 2.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW55074.1 - 0.013 15.9 0.1 0.013 15.9 0.1 2.7 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW55074.1 - 0.027 15.3 0.1 0.027 15.3 0.1 3.7 4 0 0 4 4 4 0 C2H2-type zinc finger SelP_N PF04592.14 CDW55074.1 - 4.4 6.6 8.9 7 6.0 8.9 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region EMP70 PF02990.16 CDW55076.1 - 6.4e-149 497.0 21.5 7.9e-149 496.6 21.5 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 TGF_beta PF00019.20 CDW55077.1 - 5.6e-31 107.6 0.5 1.1e-30 106.6 0.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 CDW55077.1 - 0.002 17.9 0.2 0.0055 16.5 0.2 1.8 1 1 0 1 1 1 1 TGF-beta propeptide AHL_synthase PF17327.2 CDW55077.1 - 0.18 10.8 0.2 0.38 9.7 0.2 1.4 1 0 0 1 1 1 0 Acyl homoserine lactone synthase CBFD_NFYB_HMF PF00808.23 CDW55078.1 - 0.00089 19.5 0.2 0.0017 18.6 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CBF PF03914.17 CDW55078.1 - 0.039 14.0 0.0 0.044 13.8 0.0 1.1 1 0 0 1 1 1 0 CBF/Mak21 family PLN_propep PF16485.5 CDW55078.1 - 0.1 12.3 0.2 0.31 10.8 0.1 1.9 2 0 0 2 2 2 0 Protealysin propeptide MMR_HSR1_C PF08438.10 CDW55078.1 - 0.14 12.7 0.0 0.16 12.6 0.0 1.3 1 1 0 1 1 1 0 GTPase of unknown function C-terminal Baculo_E56 PF04639.12 CDW55078.1 - 0.17 11.1 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope Med30 PF11315.8 CDW55079.1 - 2.1e-13 50.7 1.4 2.8e-13 50.3 1.4 1.2 1 0 0 1 1 1 1 Mediator complex subunit 30 UPF0449 PF15136.6 CDW55079.1 - 0.018 15.5 2.3 0.98 9.9 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF2959 PF11172.8 CDW55079.1 - 0.039 14.1 1.0 0.062 13.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) FlaC_arch PF05377.11 CDW55079.1 - 0.42 11.0 2.5 1.7 9.1 0.5 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) PMI_typeI PF01238.21 CDW55080.1 - 2e-114 382.7 0.0 2.3e-114 382.5 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I P_C10 PF14974.6 CDW55081.1 - 7.5e-19 67.8 0.2 8.5e-19 67.6 0.2 1.0 1 0 0 1 1 1 1 Protein C10 CdiI_2 PF18593.1 CDW55081.1 - 0.0084 16.7 0.4 0.17 12.5 0.2 2.0 1 1 1 2 2 2 1 CdiI immunity protein FliT PF05400.13 CDW55081.1 - 0.047 14.5 1.9 0.12 13.2 1.9 1.8 1 1 0 1 1 1 0 Flagellar protein FliT CBM_14 PF01607.24 CDW55082.1 - 1.9e-76 252.0 104.2 5.9e-10 39.2 2.4 9.3 9 0 0 9 9 9 9 Chitin binding Peritrophin-A domain TSP_1 PF00090.19 CDW55082.1 - 2.2e-05 24.6 1.8 2.2e-05 24.6 1.8 5.0 5 0 0 5 5 5 1 Thrombospondin type 1 domain Mfa_like_1 PF13149.6 CDW55082.1 - 0.036 14.1 6.0 0.26 11.3 2.4 2.5 2 0 0 2 2 2 0 Fimbrillin-like FERM_C PF09380.10 CDW55083.1 - 8.7e-20 70.9 0.3 1.8e-19 69.9 0.3 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 CDW55083.1 - 2.6e-14 53.6 0.1 6e-14 52.5 0.1 1.6 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 CDW55083.1 - 7.5e-12 45.0 0.2 1.9e-11 43.8 0.1 1.7 2 0 0 2 2 2 1 FERM N-terminal domain FA PF08736.11 CDW55083.1 - 1.3e-09 37.9 0.8 4e-09 36.4 0.8 1.8 1 0 0 1 1 1 1 FERM adjacent (FA) I-set PF07679.16 CDW55084.1 - 2.2e-49 165.5 0.1 2.3e-15 56.4 0.0 4.5 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW55084.1 - 1.2e-48 163.6 1.7 5.6e-13 49.3 0.0 4.6 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 CDW55084.1 - 1.2e-31 108.9 0.3 4.3e-08 33.4 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 CDW55084.1 - 8.3e-31 106.0 1.3 2.4e-08 34.1 0.2 4.9 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 CDW55084.1 - 2.4e-13 50.2 6.3 0.17 12.1 0.0 7.1 5 3 3 8 8 8 4 Immunoglobulin V-set domain Ig_4 PF16680.5 CDW55084.1 - 5.8e-07 29.7 0.0 1.1 9.6 0.0 4.4 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 CDW55084.1 - 3.1e-05 23.9 2.3 0.069 13.2 0.2 4.2 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 CDW55084.1 - 4e-05 23.9 1.5 1.2 9.5 0.0 4.4 4 1 0 4 4 4 2 Immunoglobulin C1-set domain Izumo-Ig PF16706.5 CDW55084.1 - 0.0037 17.3 0.1 14 5.8 0.0 4.6 4 1 0 4 4 4 1 Izumo-like Immunoglobulin domain VWA_2 PF13519.6 CDW55084.1 - 0.0069 17.0 0.4 0.028 15.0 0.0 2.3 3 0 0 3 3 3 1 von Willebrand factor type A domain DUF3367 PF11847.8 CDW55086.1 - 0.055 11.3 0.2 0.1 10.5 0.2 1.3 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase zf_ZIC PF18366.1 CDW55091.1 - 5e-13 48.9 2.9 1.4e-11 44.3 0.4 3.0 2 1 1 3 3 3 1 Zic proteins zinc finger domain zf-C2H2 PF00096.26 CDW55091.1 - 8.1e-11 41.8 17.5 0.00053 20.3 0.1 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW55091.1 - 6.3e-10 39.0 13.8 3.6e-06 27.2 1.2 4.0 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW55091.1 - 1.8e-05 25.2 14.1 0.65 11.0 0.1 4.9 4 0 0 4 4 4 3 C2H2-type zinc finger DUF3454 PF11936.8 CDW55091.1 - 0.0047 17.3 0.7 0.012 16.0 0.7 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3454) zf-C2H2_jaz PF12171.8 CDW55091.1 - 0.88 9.9 5.3 20 5.6 0.2 3.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 CDW55091.1 - 3.4 8.4 6.2 35 5.1 0.1 3.5 2 1 1 3 3 3 0 FOXP coiled-coil domain PRP1_N PF06424.12 CDW55092.1 - 2.4e-49 167.6 6.3 2.4e-49 167.6 6.3 1.7 2 0 0 2 2 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CDW55092.1 - 3.1e-30 102.3 22.0 0.0003 21.4 0.1 13.2 7 4 9 16 16 14 7 Tetratricopeptide repeat TPR_19 PF14559.6 CDW55092.1 - 1.5e-19 70.3 5.0 2.5e-05 24.7 0.1 9.1 7 3 4 11 11 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDW55092.1 - 5.5e-08 33.3 5.7 0.034 14.8 0.3 7.5 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDW55092.1 - 1.5e-07 31.3 2.3 0.083 13.3 0.1 7.5 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW55092.1 - 4.6e-06 26.2 0.9 0.29 10.9 0.0 5.7 4 1 2 6 6 6 1 TPR repeat TPR_8 PF13181.6 CDW55092.1 - 1.5e-05 24.8 3.2 0.02 15.0 0.0 5.8 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDW55092.1 - 2.8e-05 23.5 11.1 0.19 10.9 0.0 6.6 3 1 2 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55092.1 - 9.3e-05 22.3 16.9 0.01 15.9 0.0 9.1 13 0 0 13 13 11 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDW55092.1 - 0.00096 18.9 0.9 0.035 13.9 0.0 4.1 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW55092.1 - 0.0015 19.0 4.0 36 5.3 0.0 7.7 9 0 0 9 9 7 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDW55092.1 - 0.0027 17.4 5.6 0.28 10.9 0.1 4.7 3 1 2 5 5 5 1 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 CDW55092.1 - 0.0028 17.8 1.6 18 5.6 0.0 5.2 6 1 0 6 6 4 0 Tetratricopeptide repeat Suf PF05843.14 CDW55092.1 - 0.0095 16.0 0.2 2.2 8.2 0.0 4.0 6 0 0 6 6 6 1 Suppressor of forked protein (Suf) Babuvirus_MP PF07234.11 CDW55092.1 - 0.011 15.9 0.0 4.9 7.3 0.0 4.2 4 1 0 4 4 4 0 Movement and RNA silencing protein DUF3808 PF10300.9 CDW55092.1 - 0.021 13.6 1.3 17 4.0 0.0 4.3 3 1 2 5 5 5 0 Protein of unknown function (DUF3808) ChAPs PF09295.10 CDW55092.1 - 0.034 13.2 0.8 2.3 7.1 0.3 2.8 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) AAA_23 PF13476.6 CDW55092.1 - 0.067 13.7 2.6 0.17 12.4 2.6 1.6 1 0 0 1 1 1 0 AAA domain Hen1_Lam_C PF18441.1 CDW55092.1 - 0.078 12.8 0.0 11 5.9 0.0 2.4 1 1 0 2 2 2 0 Hen1 La-motif C-terminal domain NARP1 PF12569.8 CDW55092.1 - 0.15 10.9 6.9 9.7 5.0 0.0 4.1 4 0 0 4 4 4 0 NMDA receptor-regulated protein 1 TPR_12 PF13424.6 CDW55092.1 - 0.17 12.2 7.8 22 5.4 0.2 5.4 5 1 1 6 6 5 0 Tetratricopeptide repeat WXG100 PF06013.12 CDW55092.1 - 0.23 11.7 0.9 17 5.7 0.1 2.6 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DUF3682 PF12446.8 CDW55092.1 - 0.25 11.8 2.0 0.48 10.9 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) MIT PF04212.18 CDW55092.1 - 1.2 9.2 0.0 1.2 9.2 0.0 6.0 6 1 0 7 7 6 0 MIT (microtubule interacting and transport) domain Abhydrolase_6 PF12697.7 CDW55093.1 - 3.4e-17 63.8 0.0 4.2e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDW55093.1 - 4.6e-12 46.1 0.1 6.8e-11 42.3 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold PGAP1 PF07819.13 CDW55093.1 - 1.3e-05 25.1 0.0 4.8e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 CDW55093.1 - 2.5e-05 23.7 0.0 4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CDW55093.1 - 4.1e-05 23.8 0.0 5.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain DUF676 PF05057.14 CDW55093.1 - 4.3e-05 23.1 0.0 6.8e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase PF00151.19 CDW55093.1 - 0.035 13.4 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipase Lipase_3 PF01764.25 CDW55093.1 - 0.053 13.4 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Mac PF12464.8 CDW55095.1 - 0.021 15.1 0.4 0.075 13.3 0.4 1.9 1 0 0 1 1 1 0 Maltose acetyltransferase DehI PF10778.9 CDW55095.1 - 0.048 13.8 0.4 9.7 6.3 0.4 3.4 2 0 0 2 2 2 0 Halocarboxylic acid dehydrogenase DehI ApoO PF09769.9 CDW55095.1 - 0.2 11.6 3.3 1.8 8.6 0.1 2.8 2 0 0 2 2 2 0 Apolipoprotein O S1 PF00575.23 CDW55096.1 - 1.6e-16 60.4 0.0 2.6e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain SHS2_Rpb7-N PF03876.17 CDW55096.1 - 1.3e-12 47.9 0.4 2.4e-12 47.0 0.1 1.6 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 RNA_pol_Rbc25 PF08292.12 CDW55096.1 - 0.0013 18.9 0.0 0.0019 18.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 CxC6 PF18721.1 CDW55097.1 - 0.64 10.3 2.7 1.7 9.0 0.4 2.1 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases Surp PF01805.20 CDW55098.1 - 2.2e-42 142.8 5.4 1.6e-21 76.1 0.2 2.6 2 0 0 2 2 2 2 Surp module TANGO2 PF05742.12 CDW55098.1 - 5.2e-42 144.6 0.0 2.1e-24 87.0 0.0 2.7 2 1 1 3 3 3 2 Transport and Golgi organisation 2 PRP21_like_P PF12230.8 CDW55098.1 - 8e-41 140.3 7.8 2e-40 139.0 7.8 1.7 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein ubiquitin PF00240.23 CDW55098.1 - 5.7e-14 51.6 0.1 1.7e-13 50.1 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 CDW55098.1 - 0.0072 16.8 0.2 0.024 15.1 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin-like domain bZIP_1 PF00170.21 CDW55099.1 - 2.3e-09 37.2 14.4 3.6e-09 36.6 14.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CDW55099.1 - 1.9e-07 31.0 15.6 3.2e-07 30.3 15.6 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CDW55099.1 - 1.2e-06 28.9 9.9 2.4e-06 28.0 9.9 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Fib_alpha PF08702.10 CDW55099.1 - 0.0061 16.7 0.9 0.01 16.0 0.9 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family NYD-SP28_assoc PF14775.6 CDW55099.1 - 0.11 12.7 2.9 0.19 11.9 2.9 1.4 1 0 0 1 1 1 0 Sperm tail C-terminal domain DUF4407 PF14362.6 CDW55099.1 - 0.17 11.2 0.2 0.24 10.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_13 PF13166.6 CDW55099.1 - 0.56 8.8 2.2 0.74 8.4 2.2 1.1 1 0 0 1 1 1 0 AAA domain 7tm_1 PF00001.21 CDW55101.1 - 1.3e-10 41.1 16.0 1.1e-09 38.0 16.0 2.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 CDW55101.1 - 4.5e-10 39.1 4.0 2.9e-06 26.9 0.6 3.1 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 CDW55101.1 - 0.028 14.8 3.5 2.4 8.7 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) zf-H2C2_2 PF13465.6 CDW55102.1 - 1.1e-38 129.9 38.2 7.9e-09 35.5 1.1 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.26 CDW55102.1 - 8.8e-20 70.0 45.1 0.00061 20.1 3.4 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW55102.1 - 3.9e-17 61.5 45.9 0.0016 19.1 2.9 6.3 6 0 0 6 6 6 6 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CDW55102.1 - 6.7e-15 54.5 44.3 5.8e-07 29.1 0.6 6.7 6 1 0 6 6 6 4 C2H2-type zinc-finger domain zf-C2HE PF16278.5 CDW55102.1 - 0.00016 22.0 21.2 0.18 12.3 1.0 4.4 2 1 2 4 4 4 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 CDW55102.1 - 0.00034 20.3 23.9 0.0097 15.6 0.5 5.8 6 0 0 6 6 6 2 zinc-finger C2H2-type zf-Di19 PF05605.12 CDW55102.1 - 0.00045 20.4 30.1 0.012 15.9 3.3 3.6 2 1 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CDW55102.1 - 0.00081 19.7 28.1 0.0016 18.8 2.7 4.6 1 1 3 4 4 4 1 C2H2 type zinc-finger (2 copies) Zn-C2H2_12 PF18112.1 CDW55102.1 - 0.012 16.1 2.4 0.012 16.1 2.4 3.9 5 0 0 5 5 4 0 Autophagy receptor zinc finger-C2H2 domain GAGA PF09237.11 CDW55102.1 - 0.022 14.6 20.3 0.092 12.6 0.6 4.7 1 1 4 5 5 5 0 GAGA factor zf-C2H2_jaz PF12171.8 CDW55102.1 - 0.042 14.1 0.9 0.042 14.1 0.9 6.3 7 1 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 CDW55102.1 - 0.066 13.5 20.1 1.8 8.9 2.6 3.3 1 1 1 2 2 2 0 C2H2-type zinc ribbon HTH_18 PF12833.7 CDW55102.1 - 0.17 12.2 0.3 38 4.6 0.0 3.2 4 0 0 4 4 3 0 Helix-turn-helix domain zinc_ribbon_15 PF17032.5 CDW55102.1 - 0.78 10.5 20.4 4.8 8.0 2.7 4.1 1 1 3 4 4 4 0 zinc-ribbon family Zn_ribbon_SprT PF17283.2 CDW55102.1 - 1.9 8.5 25.4 1.9 8.5 2.1 3.6 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zf_C2HC_14 PF18574.1 CDW55102.1 - 2.8 7.8 8.1 0.35 10.7 0.6 3.0 2 0 0 2 2 2 0 C2HC Zing finger domain zf_C2H2_10 PF18414.1 CDW55102.1 - 3.3 7.3 8.2 0.82 9.3 0.4 3.3 3 0 0 3 3 3 0 C2H2 type zinc-finger zf-C2H2_9 PF16293.5 CDW55102.1 - 6.6 6.7 11.9 7.6 6.5 0.5 4.4 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) FOXP-CC PF16159.5 CDW55102.1 - 8.8 7.0 11.6 37 5.0 0.2 3.7 2 1 1 3 3 3 0 FOXP coiled-coil domain RUN PF02759.19 CDW55103.1 - 1.3e-09 38.2 0.2 3.5e-09 36.7 0.2 1.9 2 0 0 2 2 2 1 RUN domain PIP49_C PF12260.8 CDW55104.1 - 4e-09 36.4 0.0 6.7e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Pkinase PF00069.25 CDW55104.1 - 0.00072 19.0 0.0 0.0015 18.0 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55104.1 - 0.0052 16.1 0.0 0.012 14.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase 2-Hacid_dh_C PF02826.19 CDW55105.1 - 3.7e-54 182.8 0.0 5.1e-54 182.3 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDW55105.1 - 7.6e-24 83.9 0.0 1e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CDW55105.1 - 3e-06 27.5 0.0 5.3e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CDW55105.1 - 0.17 11.4 0.0 0.47 10.0 0.0 1.7 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain MFS_1 PF07690.16 CDW55106.1 - 3e-34 118.5 46.1 2.5e-23 82.6 14.0 2.7 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_4 PF06779.14 CDW55106.1 - 1.5e-10 40.9 31.8 3.1e-07 30.0 13.4 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF21 PF01595.20 CDW55106.1 - 0.12 12.1 4.6 0.34 10.6 4.6 1.8 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain CbtA PF09490.10 CDW55106.1 - 0.71 9.6 11.5 0.028 14.2 2.8 2.8 2 1 1 3 3 3 0 Probable cobalt transporter subunit (CbtA) Homeodomain PF00046.29 CDW55107.1 - 9.5e-22 76.6 5.8 1.9e-21 75.6 5.8 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW55107.1 - 0.078 12.9 0.3 0.2 11.6 0.3 1.7 1 0 0 1 1 1 0 Homeobox KN domain EGF PF00008.27 CDW55108.1 - 4.6e-23 81.2 105.6 3.6e-05 24.0 7.8 8.6 8 0 0 8 8 8 6 EGF-like domain Ank_2 PF12796.7 CDW55108.1 - 8.7e-22 77.5 7.0 6e-09 36.4 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Notch PF00066.17 CDW55108.1 - 3.9e-18 65.6 38.1 7e-11 42.4 9.5 6.8 8 0 0 8 8 8 3 LNR domain Ank_5 PF13857.6 CDW55108.1 - 1.4e-14 53.9 4.5 1.3e-06 28.6 0.2 4.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) hEGF PF12661.7 CDW55108.1 - 6.2e-14 52.0 75.6 6.8e-07 29.7 5.3 9.1 8 0 0 8 8 8 6 Human growth factor-like EGF Ank_3 PF13606.6 CDW55108.1 - 4.9e-10 38.8 6.0 0.12 13.0 0.0 6.9 7 0 0 7 7 7 2 Ankyrin repeat NOD PF06816.13 CDW55108.1 - 3.4e-09 36.2 0.0 8e-09 35.0 0.0 1.7 1 0 0 1 1 1 1 NOTCH protein Ank_4 PF13637.6 CDW55108.1 - 7.5e-09 36.0 6.5 0.00042 20.8 0.0 4.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CDW55108.1 - 1.8e-08 34.5 8.0 0.081 13.4 0.0 6.7 8 0 0 8 8 8 2 Ankyrin repeat RRM_5 PF13893.6 CDW55109.1 - 1.7e-91 302.3 0.1 1.1e-37 128.4 0.0 7.6 8 0 0 8 8 8 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 CDW55109.1 - 5.9e-64 211.8 0.3 2.3e-06 27.3 0.0 11.4 11 0 0 11 11 11 11 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 CDW55109.1 - 9.4e-27 93.1 0.6 1.8e-09 37.7 0.2 3.5 3 0 0 3 3 3 3 RRM-like domain RRM_occluded PF16842.5 CDW55109.1 - 6.6e-12 45.1 7.1 0.39 10.6 0.0 9.3 10 0 0 10 10 10 4 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CDW55109.1 - 1.3e-07 31.5 0.7 0.55 10.3 0.0 6.2 7 0 0 7 7 7 2 Limkain b1 DUF4523 PF15023.6 CDW55109.1 - 1.2e-05 25.2 0.3 0.06 13.2 0.0 3.9 3 0 0 3 3 3 1 Protein of unknown function (DUF4523) RRM_3 PF08777.11 CDW55109.1 - 3.7e-05 23.7 0.7 18 5.4 0.0 6.5 8 0 0 8 8 8 2 RNA binding motif RL PF17797.1 CDW55109.1 - 0.00034 20.5 0.0 26 4.8 0.0 6.2 7 0 0 7 7 7 0 RL domain RRM_7 PF16367.5 CDW55109.1 - 0.11 12.7 0.0 11 6.3 0.0 3.7 3 0 0 3 3 3 0 RNA recognition motif Integrin_beta PF00362.18 CDW55110.1 - 3.2e-105 351.2 0.0 4.5e-105 350.8 0.0 1.2 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 CDW55110.1 - 2.2e-23 81.7 0.1 3.8e-23 80.9 0.1 1.4 1 0 0 1 1 1 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 CDW55110.1 - 3.9e-19 68.9 3.7 3.9e-19 68.9 3.7 4.3 3 1 2 5 5 5 1 Integrin beta tail domain PSI_integrin PF17205.3 CDW55110.1 - 4e-10 39.3 9.2 4e-10 39.3 9.2 3.7 2 0 0 2 2 2 1 Integrin plexin domain I-EGF_1 PF18372.1 CDW55110.1 - 4.3e-10 39.5 60.4 3.3e-06 27.1 3.3 5.6 5 0 0 5 5 5 4 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 CDW55110.1 - 3.3e-06 27.4 80.2 0.0024 18.2 12.8 6.2 5 1 0 5 5 5 3 EGF-like domain DUF2975 PF11188.8 CDW55110.1 - 0.11 12.3 0.1 0.19 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) Collectrin PF16959.5 CDW55110.1 - 1.4 8.6 3.1 0.73 9.6 0.7 1.7 2 0 0 2 2 2 0 Renal amino acid transporter Motile_Sperm PF00635.26 CDW55111.1 - 1.4e-18 66.7 2.0 1.8e-18 66.4 2.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF5001 PF16392.5 CDW55111.1 - 0.0031 17.4 0.2 0.0046 16.8 0.2 1.3 1 0 0 1 1 1 1 Ig-like domain ASH PF15780.5 CDW55111.1 - 0.0034 17.6 0.2 0.0048 17.1 0.2 1.3 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin HMG_box PF00505.19 CDW55112.1 - 7.2e-37 125.6 14.2 1e-22 80.3 3.2 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW55112.1 - 4.3e-35 120.1 15.9 8.6e-20 71.1 5.0 2.2 2 0 0 2 2 2 2 HMG-box domain FTCD_C PF04961.12 CDW55112.1 - 0.38 10.5 6.0 1.5 8.6 2.2 2.1 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase COX4 PF02936.14 CDW55112.1 - 0.6 10.1 11.5 0.52 10.3 2.0 2.7 3 1 0 3 3 3 0 Cytochrome c oxidase subunit IV Ccdc124 PF06244.12 CDW55112.1 - 0.74 10.4 10.7 0.051 14.1 4.8 1.9 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 124 /Oxs1 P-mevalo_kinase PF04275.14 CDW55112.1 - 0.81 9.7 6.4 0.22 11.5 1.6 2.0 2 0 0 2 2 2 0 Phosphomevalonate kinase DUF1289 PF06945.13 CDW55112.1 - 1.9 8.4 6.3 6.4 6.7 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1289) HMG_box_5 PF14887.6 CDW55112.1 - 2.1 8.3 13.3 5 7.2 2.7 2.5 2 1 0 2 2 2 0 HMG (high mobility group) box 5 Aldolase_II PF00596.21 CDW55113.1 - 7.5e-39 133.6 0.0 1.3e-38 132.8 0.0 1.4 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain TPR_19 PF14559.6 CDW55114.1 - 1e-33 115.6 34.3 7.7e-08 32.7 0.3 10.6 8 3 3 11 11 11 7 Tetratricopeptide repeat TPR_14 PF13428.6 CDW55114.1 - 1.4e-23 81.5 7.7 0.016 16.0 0.0 10.9 8 2 3 11 11 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55114.1 - 2.9e-20 70.7 35.4 0.11 12.7 0.0 14.6 15 0 0 15 15 15 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55114.1 - 5.2e-20 69.9 34.6 0.0032 17.6 0.0 12.5 13 0 0 13 13 13 7 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW55114.1 - 6.7e-13 48.7 35.4 0.0025 18.0 1.0 7.7 6 2 1 7 7 7 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDW55114.1 - 8.4e-12 45.2 24.9 0.13 12.6 0.0 8.6 8 3 2 10 10 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 CDW55114.1 - 3.6e-11 42.6 22.0 0.028 14.8 0.0 10.1 10 1 1 11 11 10 3 Tetratricopeptide repeat TPR_4 PF07721.14 CDW55114.1 - 5.1e-11 42.1 0.0 0.24 12.1 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW55114.1 - 4.6e-10 40.0 7.8 0.0056 17.3 0.4 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW55114.1 - 4e-09 36.5 19.5 0.14 12.9 0.1 9.6 11 0 0 11 11 8 1 Tetratricopeptide repeat TPR_21 PF09976.9 CDW55114.1 - 2e-08 34.2 19.3 0.032 13.9 1.6 6.1 3 3 1 5 5 5 3 Tetratricopeptide repeat-like domain TPR_1 PF00515.28 CDW55114.1 - 5.7e-08 32.2 41.9 0.45 10.4 1.1 12.7 14 0 0 14 14 14 3 Tetratricopeptide repeat TPR_20 PF14561.6 CDW55114.1 - 1.2e-05 25.6 16.3 0.23 11.8 0.4 7.2 6 3 2 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW55114.1 - 2.5e-05 23.8 14.9 0.00015 21.2 4.2 4.1 3 2 1 4 4 4 1 MalT-like TPR region SHNi-TPR PF10516.9 CDW55114.1 - 4.3e-05 22.9 3.0 0.00044 19.6 0.1 3.8 4 0 0 4 4 4 1 SHNi-TPR TPR_7 PF13176.6 CDW55114.1 - 0.0002 21.1 21.2 1.1 9.4 0.0 9.5 10 1 0 10 10 9 1 Tetratricopeptide repeat LppC PF04348.13 CDW55114.1 - 0.0093 14.8 7.2 0.035 12.9 0.7 3.2 3 1 1 4 4 4 1 LppC putative lipoprotein DUF2064 PF09837.9 CDW55114.1 - 0.012 15.4 0.0 0.04 13.7 0.0 1.9 2 0 0 2 2 1 0 Uncharacterized protein conserved in bacteria (DUF2064) ChAPs PF09295.10 CDW55114.1 - 0.019 14.0 7.1 6.6 5.6 0.1 3.5 3 0 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) YfiO PF13525.6 CDW55114.1 - 0.05 13.3 7.5 0.86 9.3 0.3 3.7 3 0 0 3 3 3 0 Outer membrane lipoprotein ANAPC5 PF12862.7 CDW55114.1 - 0.086 12.9 12.1 3.7 7.7 3.9 4.4 2 2 0 2 2 2 0 Anaphase-promoting complex subunit 5 SIX1_SD PF16878.5 CDW55114.1 - 5.6 7.5 7.1 0.44 11.1 0.2 2.7 4 0 0 4 4 2 0 Transcriptional regulator, SIX1, N-terminal SD domain Spb1_C PF07780.12 CDW55115.1 - 9.1e-38 130.0 4.1 9.1e-38 130.0 4.1 2.5 2 1 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 CDW55115.1 - 4.4e-36 124.6 0.0 8.4e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 CDW55115.1 - 2e-33 115.5 3.7 2e-33 115.5 3.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3381) DUF305 PF03713.13 CDW55115.1 - 0.003 17.7 0.4 0.0059 16.7 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF305) SNARE PF05739.19 CDW55116.1 - 8.6e-13 48.1 5.3 9.2e-13 48.0 0.6 2.5 2 1 1 3 3 3 1 SNARE domain Syntaxin PF00804.25 CDW55116.1 - 0.00051 19.8 8.8 0.0013 18.4 0.5 2.2 2 0 0 2 2 2 2 Syntaxin MCPsignal PF00015.21 CDW55116.1 - 0.035 13.9 5.0 0.062 13.1 0.2 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2203 PF09969.9 CDW55116.1 - 0.21 12.3 1.3 3.8 8.2 0.1 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Syntaxin_2 PF14523.6 CDW55116.1 - 0.3 11.5 10.5 3.7 8.0 4.3 2.3 2 0 0 2 2 2 0 Syntaxin-like protein Synaptobrevin PF00957.21 CDW55116.1 - 0.65 9.8 9.0 1.4 8.8 2.0 2.9 2 2 0 2 2 2 0 Synaptobrevin T2SSF PF00482.23 CDW55116.1 - 2.2 8.2 4.8 2 8.4 0.6 2.6 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F DUF1664 PF07889.12 CDW55116.1 - 3 7.9 6.5 9.5 6.3 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) MFS_1 PF07690.16 CDW55117.1 - 1.3e-47 162.4 13.1 6.6e-26 91.1 2.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Peptidase_S8 PF00082.22 CDW55119.1 - 6.9e-51 173.3 2.3 9.9e-51 172.8 2.3 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 CDW55119.1 - 4.9e-28 97.0 0.7 1.2e-27 95.7 0.5 1.8 2 0 0 2 2 2 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 CDW55119.1 - 1.3e-22 80.3 0.0 4.1e-22 78.7 0.1 1.8 2 0 0 2 2 2 1 Peptidase S8 pro-domain HATPase_c_3 PF13589.6 CDW55120.1 - 1.3e-10 41.2 0.0 1.7e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDW55120.1 - 1.1e-07 32.3 0.0 1.4e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BrkDBD PF09607.10 CDW55121.1 - 1.1e-09 37.9 0.1 1.4e-09 37.5 0.1 1.2 1 0 0 1 1 1 1 Brinker DNA-binding domain DUF1512 PF07431.12 CDW55121.1 - 0.0098 14.9 0.3 0.011 14.8 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1512) Peptidase_U57 PF05582.12 CDW55121.1 - 0.072 12.3 0.0 0.076 12.3 0.0 1.0 1 0 0 1 1 1 0 YabG peptidase U57 TORC_N PF12884.7 CDW55123.1 - 2.5e-15 57.0 0.1 3.4e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 Transducer of regulated CREB activity, N terminus Actin PF00022.19 CDW55125.1 - 6.6e-12 44.8 0.1 6.9e-12 44.7 0.1 1.0 1 0 0 1 1 1 1 Actin Aldo_ket_red PF00248.21 CDW55126.1 - 1.2e-49 169.1 0.0 1.7e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family PD40 PF07676.12 CDW55127.1 - 8.5e-31 105.2 4.7 1.2e-07 31.4 0.1 6.1 6 0 0 6 6 6 5 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 CDW55127.1 - 2.5e-06 26.5 0.1 0.00099 18.0 0.0 3.1 3 1 0 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pectate_lyase22 PF14583.6 CDW55127.1 - 0.00092 18.0 1.7 0.091 11.4 0.0 2.8 2 1 1 3 3 3 2 Oligogalacturonate lyase Polbeta PF18765.1 CDW55128.1 - 0.002 18.2 0.0 0.0054 16.8 0.0 1.7 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 CDW55128.1 - 0.0032 17.7 0.0 0.015 15.6 0.0 2.1 1 1 1 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 CDW55128.1 - 0.019 15.2 0.2 0.061 13.5 0.2 1.9 1 0 0 1 1 1 0 Cid1 family poly A polymerase Aldo_ket_red PF00248.21 CDW55129.1 - 4.5e-48 164.0 0.0 5.2e-48 163.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 CDW55130.1 - 2.9e-24 85.8 0.0 5.2e-24 85.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55130.1 - 2.7e-12 46.5 0.1 1.2e-11 44.4 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW55130.1 - 0.0025 16.7 0.0 0.0034 16.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDW55130.1 - 0.062 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DSPc PF00782.20 CDW55131.1 - 1.5e-11 44.3 0.0 2e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW55131.1 - 9.6e-05 22.1 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CDW55131.1 - 0.00021 21.5 0.0 0.0003 20.9 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 CDW55131.1 - 0.0025 17.8 0.0 0.0031 17.5 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CDW55132.1 - 2.1e-11 43.8 0.0 2.9e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW55132.1 - 8.4e-05 22.3 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CDW55132.1 - 0.00027 21.1 0.0 0.00039 20.6 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 CDW55132.1 - 0.0028 17.7 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Ras PF00071.22 CDW55133.1 - 1.3e-62 210.2 0.1 1.5e-62 210.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW55133.1 - 2.3e-33 115.0 0.1 4.4e-33 114.1 0.1 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW55133.1 - 9.9e-13 47.9 0.0 1.2e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW55133.1 - 4.7e-05 23.4 0.0 7.3e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW55133.1 - 0.00032 20.1 0.0 0.00051 19.5 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDW55133.1 - 0.00077 19.1 0.1 0.0039 16.7 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW55133.1 - 0.0014 18.6 0.1 0.29 11.0 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 CDW55133.1 - 0.011 15.5 0.2 0.024 14.3 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDW55133.1 - 0.036 14.3 0.1 0.21 11.8 0.1 2.3 1 1 1 2 2 2 0 AAA domain DAP3 PF10236.9 CDW55133.1 - 0.088 12.0 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Use1 PF09753.9 CDW55135.1 - 0.0088 15.8 0.8 0.014 15.1 0.8 1.3 1 0 0 1 1 1 1 Membrane fusion protein Use1 Senescence PF06911.12 CDW55136.1 - 4.3e-28 98.9 2.0 4.3e-28 98.9 2.0 1.8 1 1 1 2 2 2 1 Senescence-associated protein RRM_1 PF00076.22 CDW55136.1 - 6.4e-05 22.7 0.0 0.00018 21.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIT PF04212.18 CDW55136.1 - 6.9e-05 22.8 0.1 0.00046 20.2 0.0 2.5 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain DUF4651 PF15513.6 CDW55136.1 - 0.054 13.3 0.8 0.26 11.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) Arm PF00514.23 CDW55137.1 - 2.1e-41 138.7 21.8 1.1e-06 28.4 0.0 10.5 10 0 0 10 10 10 8 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 CDW55137.1 - 4.3e-07 30.2 3.3 0.37 11.2 0.4 5.8 4 2 0 5 5 5 1 HEAT repeats Cnd1 PF12717.7 CDW55137.1 - 2e-05 24.7 3.7 0.025 14.7 0.3 3.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDW55137.1 - 0.00031 19.5 12.2 0.00083 18.0 1.2 3.5 1 1 3 4 4 4 3 Adaptin N terminal region DRIM PF07539.12 CDW55137.1 - 0.00052 18.5 0.3 0.0027 16.1 0.1 2.0 1 1 1 2 2 2 1 Down-regulated in metastasis DUF3361 PF11841.8 CDW55137.1 - 0.0017 18.3 7.1 0.21 11.5 0.2 4.6 2 2 3 6 6 6 1 Domain of unknown function (DUF3361) HEAT PF02985.22 CDW55137.1 - 0.0065 16.6 6.2 5.7 7.5 0.0 6.0 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 CDW55137.1 - 0.012 16.1 4.6 27 5.4 0.1 5.4 5 1 1 6 6 5 0 HEAT-like repeat Atx10homo_assoc PF09759.9 CDW55137.1 - 0.03 14.3 3.3 0.54 10.3 2.2 2.9 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain CODH_A_N PF18537.1 CDW55137.1 - 0.031 14.3 0.0 0.078 13.0 0.0 1.7 1 0 0 1 1 1 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain V-ATPase_H_N PF03224.14 CDW55137.1 - 0.099 11.9 2.0 1.7 7.8 0.2 3.0 1 1 1 3 3 3 0 V-ATPase subunit H Pes-10 PF07149.11 CDW55137.1 - 0.12 11.4 0.3 0.8 8.7 0.0 2.1 2 0 0 2 2 2 0 Pes-10 Rcd1 PF04078.13 CDW55137.1 - 0.19 11.0 4.7 3.7 6.7 0.2 3.7 3 2 1 5 5 5 0 Cell differentiation family, Rcd1-like RasGEF_N_2 PF14663.6 CDW55137.1 - 0.31 11.4 5.1 93 3.5 0.2 4.7 5 1 1 6 6 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain PFK PF00365.20 CDW55138.1 - 7.4e-196 648.9 1.5 1.2e-105 352.9 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase PAH PF02671.21 CDW55139.1 - 2.2e-09 37.3 0.2 4.8e-09 36.2 0.2 1.6 1 0 0 1 1 1 1 Paired amphipathic helix repeat WD40 PF00400.32 CDW55139.1 - 2.8e-05 24.8 6.5 0.031 15.1 0.1 4.6 4 1 0 4 4 4 3 WD domain, G-beta repeat STAR_dimer PF16544.5 CDW55140.1 - 4.9e-10 38.8 0.3 1.5e-09 37.3 0.3 1.8 1 1 0 1 1 1 1 Homodimerisation region of STAR domain protein KH_1 PF00013.29 CDW55140.1 - 4.6e-06 26.4 0.0 9e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 KH domain DUF3905 PF13045.6 CDW55141.1 - 0.032 14.2 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3905) Snf7 PF03357.21 CDW55142.1 - 2.2e-08 33.9 21.5 1.3e-07 31.4 10.5 2.6 1 1 1 2 2 2 2 Snf7 AcetylCoA_hydro PF02550.15 CDW55142.1 - 0.0012 18.8 0.6 0.0029 17.6 0.6 1.6 1 1 1 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain ThiF PF00899.21 CDW55142.1 - 0.028 13.8 0.1 0.035 13.5 0.1 1.3 1 0 0 1 1 1 0 ThiF family M20_dimer PF07687.14 CDW55142.1 - 0.052 13.5 0.2 0.14 12.1 0.2 1.8 1 1 0 1 1 1 0 Peptidase dimerisation domain Ist1 PF03398.14 CDW55142.1 - 0.078 12.9 9.9 0.36 10.8 9.9 1.8 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DUF2652 PF10851.8 CDW55142.1 - 0.81 9.8 4.1 6.3 6.9 0.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2652) Ank_3 PF13606.6 CDW55143.1 - 0.0012 19.2 0.8 0.22 12.2 0.1 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 CDW55143.1 - 0.0067 17.0 0.0 0.36 11.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) DMT_YdcZ PF04657.13 CDW55143.1 - 0.023 15.0 0.0 0.023 15.0 0.0 2.6 3 0 0 3 3 3 0 Putative inner membrane exporter, YdcZ Ank PF00023.30 CDW55143.1 - 0.045 14.2 0.0 2.5 8.7 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 CDW55143.1 - 0.062 13.6 0.0 0.35 11.3 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Voltage_CLC PF00654.20 CDW55143.1 - 1.6 7.9 5.6 3.6 6.7 5.6 1.7 1 1 0 1 1 1 0 Voltage gated chloride channel HEAT_EZ PF13513.6 CDW55145.1 - 1.3e-25 89.5 11.4 2.8e-10 40.5 0.0 8.9 6 3 3 9 9 9 5 HEAT-like repeat HEAT PF02985.22 CDW55145.1 - 3.8e-19 67.1 20.3 5.6e-05 23.1 0.0 10.8 12 0 0 12 12 10 4 HEAT repeat HEAT_2 PF13646.6 CDW55145.1 - 8.9e-15 54.9 0.5 0.01 16.2 0.0 7.6 5 3 4 9 9 9 3 HEAT repeats IBN_N PF03810.19 CDW55145.1 - 5.1e-13 48.7 0.2 2.3e-11 43.5 0.0 3.5 4 0 0 4 4 3 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 CDW55145.1 - 4.6e-09 36.7 2.3 5 7.8 0.0 6.7 6 2 2 8 8 7 2 Vacuolar 14 Fab1-binding region Arm PF00514.23 CDW55145.1 - 8.2e-08 32.0 11.6 0.51 10.5 0.1 7.7 9 0 0 9 9 8 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 CDW55145.1 - 5.5e-07 29.8 2.7 0.027 14.5 0.1 4.9 3 3 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 CDW55145.1 - 0.00011 21.4 1.8 0.0099 15.0 0.0 3.7 3 1 0 3 3 3 1 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 CDW55145.1 - 0.00016 21.3 0.1 4.8 6.7 0.1 4.6 4 1 1 5 5 5 1 CLASP N terminal Adaptin_N PF01602.20 CDW55145.1 - 0.00031 19.5 4.1 0.056 12.0 1.1 2.5 2 0 0 2 2 2 2 Adaptin N terminal region DUF3385 PF11865.8 CDW55145.1 - 0.001 19.0 2.7 0.18 11.7 0.0 5.1 6 1 1 7 7 7 1 Domain of unknown function (DUF3385) Urb2 PF10441.9 CDW55145.1 - 0.0044 17.0 0.4 0.016 15.2 0.4 2.0 1 0 0 1 1 1 1 Urb2/Npa2 family ParcG PF10274.9 CDW55145.1 - 0.013 15.6 0.2 36 4.4 0.0 4.8 5 1 1 6 6 5 0 Parkin co-regulated protein HEAT_PBS PF03130.16 CDW55145.1 - 0.022 15.4 2.4 1.9e+02 3.2 0.5 5.3 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat RasGEF_N_2 PF14663.6 CDW55145.1 - 0.039 14.3 1.8 8.1 6.9 0.0 3.7 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain TAF6_C PF07571.13 CDW55145.1 - 0.043 14.1 0.0 4.9 7.5 0.0 3.7 4 0 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain UME PF08064.13 CDW55145.1 - 0.065 13.1 2.0 27 4.7 0.1 4.6 3 1 1 4 4 4 0 UME (NUC010) domain Cnd3 PF12719.7 CDW55145.1 - 0.1 11.8 2.1 0.17 11.1 0.3 2.2 3 0 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain DUF3437 PF11919.8 CDW55145.1 - 0.15 12.0 0.1 12 5.9 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) Sulfate_transp PF00916.20 CDW55146.1 - 2.1e-100 336.2 12.4 3.4e-100 335.5 12.4 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CDW55146.1 - 5.9e-32 109.8 0.0 8.7e-32 109.2 0.0 1.3 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 CDW55146.1 - 0.006 17.0 2.8 0.006 17.0 2.8 3.0 3 0 0 3 3 3 1 Molybdate transporter of MFS superfamily MadM PF03818.13 CDW55146.1 - 0.07 13.0 1.2 6.5 6.7 0.1 3.5 2 1 1 3 3 3 0 Malonate/sodium symporter MadM subunit MNHE PF01899.16 CDW55146.1 - 2.5 7.8 12.6 0.96 9.2 1.2 3.6 3 0 0 3 3 3 0 Na+/H+ ion antiporter subunit CBM_14 PF01607.24 CDW55148.1 - 0.036 14.2 0.8 0.081 13.1 0.8 1.6 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain Y_phosphatase PF00102.27 CDW55149.1 - 2.1e-96 322.0 7.2 1e-52 179.1 1.0 2.4 3 0 0 3 3 3 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW55149.1 - 0.014 15.3 0.1 0.024 14.6 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family BPD_transp_2 PF02653.16 CDW55150.1 - 6.6e-06 25.5 8.1 6.6e-06 25.5 8.1 1.4 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component ABC_tran PF00005.27 CDW55151.1 - 7.7e-54 181.9 0.1 3.4e-28 98.9 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDW55151.1 - 1.2e-07 31.8 0.3 0.029 14.2 0.1 3.1 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW55151.1 - 6.2e-05 22.5 0.0 0.028 13.9 0.7 2.9 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain TsaE PF02367.17 CDW55151.1 - 0.0013 18.8 0.4 1.3 9.0 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CDW55151.1 - 0.0023 17.7 6.6 0.0041 16.9 0.4 3.0 3 1 0 3 3 3 1 AAA domain ABC_ATPase PF09818.9 CDW55151.1 - 0.0041 16.0 2.1 0.18 10.5 0.0 3.0 3 1 0 3 3 3 1 Predicted ATPase of the ABC class AAA_29 PF13555.6 CDW55151.1 - 0.0067 16.1 0.4 0.02 14.6 0.0 2.0 2 0 0 2 2 1 1 P-loop containing region of AAA domain MukB PF04310.12 CDW55151.1 - 0.0077 16.1 0.4 0.13 12.1 0.1 2.3 2 0 0 2 2 2 1 MukB N-terminal AAA_16 PF13191.6 CDW55151.1 - 0.0078 16.6 0.4 1.5 9.1 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain Ploopntkinase3 PF18751.1 CDW55151.1 - 0.0082 16.1 0.5 0.017 15.0 0.1 1.7 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 RsgA_GTPase PF03193.16 CDW55151.1 - 0.011 15.6 0.3 0.079 12.9 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 CDW55151.1 - 0.012 15.9 2.7 0.66 10.2 0.1 3.3 3 1 0 3 3 3 0 AAA domain AAA_15 PF13175.6 CDW55151.1 - 0.038 13.7 0.0 0.05 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CDW55151.1 - 0.04 14.0 0.1 0.3 11.2 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CDW55151.1 - 0.043 13.1 0.7 4 6.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 CDW55151.1 - 0.08 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDW55151.1 - 0.14 12.5 0.7 1.2 9.5 0.0 2.7 3 0 0 3 3 2 0 RNA helicase AAA PF00004.29 CDW55151.1 - 0.16 12.4 2.8 62 4.0 0.1 3.9 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDW55151.1 - 0.17 12.1 1.2 20 5.3 0.1 2.9 3 1 0 3 3 3 0 AAA domain K_trans PF02705.16 CDW55152.1 - 4e-206 685.7 25.4 4.6e-206 685.5 25.4 1.0 1 0 0 1 1 1 1 K+ potassium transporter AAA_5 PF07728.14 CDW55153.1 - 1.4e-25 89.9 0.2 2e-24 86.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_8 PF17868.1 CDW55153.1 - 1.4e-22 79.4 0.0 3e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain VWA_CoxE PF05762.14 CDW55153.1 - 2.3e-10 40.2 0.0 6.3e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA_2 PF13519.6 CDW55153.1 - 8.2e-07 29.6 0.0 2.8e-06 27.9 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF3763 PF12592.8 CDW55153.1 - 1.5e-05 24.9 0.7 5.9e-05 23.0 0.7 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3763) AAA_3 PF07726.11 CDW55153.1 - 0.00041 20.2 0.0 0.00086 19.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDW55153.1 - 0.00062 19.2 0.0 0.0067 15.8 0.0 2.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDW55153.1 - 0.0021 17.8 0.0 0.024 14.4 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 CDW55153.1 - 0.0024 18.3 0.0 0.006 17.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW55153.1 - 0.02 15.3 5.5 0.052 13.9 0.3 3.9 2 2 0 2 2 2 0 AAA ATPase domain AAA_PrkA PF08298.11 CDW55153.1 - 0.056 12.4 0.0 0.92 8.3 0.0 2.1 1 1 1 2 2 2 0 PrkA AAA domain AAA_2 PF07724.14 CDW55153.1 - 0.16 12.1 0.0 0.41 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AsnA PF03590.15 CDW55154.1 - 1.8e-93 312.5 0.0 2.2e-93 312.2 0.0 1.0 1 0 0 1 1 1 1 Aspartate-ammonia ligase tRNA-synt_2 PF00152.20 CDW55154.1 - 0.00039 19.6 0.0 0.0077 15.4 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) DUF5569 PF17729.1 CDW55154.1 - 0.22 11.4 0.0 0.37 10.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5569) AsnC_trans_reg PF01037.21 CDW55155.1 - 4.1e-18 65.1 0.1 7e-18 64.4 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 CDW55155.1 - 7.4e-14 51.0 0.0 1.2e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 CDW55155.1 - 2.3e-13 49.7 0.0 4.6e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.7 CDW55155.1 - 3.6e-06 26.9 0.0 6.8e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.12 CDW55155.1 - 5.5e-05 23.0 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.7 CDW55155.1 - 8.8e-05 22.3 0.0 0.00014 21.6 0.0 1.3 1 0 0 1 1 1 1 MarR family B-block_TFIIIC PF04182.12 CDW55155.1 - 0.0039 17.3 0.1 0.024 14.8 0.0 2.0 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_5 PF01022.20 CDW55155.1 - 0.007 16.2 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_28 PF13518.6 CDW55155.1 - 0.0081 16.3 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_41 PF14502.6 CDW55155.1 - 0.0093 15.6 0.1 0.065 12.9 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_IclR PF09339.10 CDW55155.1 - 0.03 14.1 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_10 PF04967.12 CDW55155.1 - 0.051 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 HTH DNA binding domain Sigma70_r4_2 PF08281.12 CDW55155.1 - 0.052 13.2 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Crp_2 PF13545.6 CDW55155.1 - 0.059 13.3 0.0 0.093 12.7 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_34 PF13601.6 CDW55155.1 - 0.06 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR PF01047.22 CDW55155.1 - 0.071 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 MarR family Flavodoxin_1 PF00258.25 CDW55156.1 - 1.2e-23 83.9 0.0 1.4e-23 83.7 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin FMN_red PF03358.15 CDW55156.1 - 0.038 13.7 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 NADPH-dependent FMN reductase GIDA PF01134.22 CDW55157.1 - 1.3e-170 567.8 0.0 1.9e-170 567.2 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CDW55157.1 - 2.9e-79 266.1 0.3 4.6e-79 265.5 0.3 1.3 1 0 0 1 1 1 1 GidA associated domain GidB PF02527.15 CDW55157.1 - 3.6e-67 225.2 0.0 5.9e-67 224.6 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G FAD_oxidored PF12831.7 CDW55157.1 - 1.3e-07 31.3 3.7 2.4e-07 30.5 3.7 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDW55157.1 - 1.5e-07 30.9 3.0 0.00025 20.3 0.3 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CDW55157.1 - 3.9e-05 23.0 1.3 9.1e-05 21.8 1.3 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDW55157.1 - 5.1e-05 22.7 0.9 0.00016 21.0 0.9 1.9 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Methyltransf_31 PF13847.6 CDW55157.1 - 5.3e-05 23.1 0.0 0.00041 20.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain HI0933_like PF03486.14 CDW55157.1 - 0.0002 20.2 2.9 0.0036 16.1 0.2 2.9 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 CDW55157.1 - 0.00081 19.1 0.7 1.2 8.7 0.0 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Methyltransf_25 PF13649.6 CDW55157.1 - 0.0011 19.6 0.0 0.0095 16.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Thi4 PF01946.17 CDW55157.1 - 0.0069 15.7 1.8 0.053 12.8 1.8 2.3 1 1 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CDW55157.1 - 0.014 15.9 0.2 0.048 14.2 0.2 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW55157.1 - 0.3 11.4 0.9 1.9 8.8 0.5 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CDW55157.1 - 0.48 9.6 1.9 1.2 8.3 0.1 2.2 3 0 0 3 3 3 0 FAD binding domain NAD_binding_9 PF13454.6 CDW55157.1 - 0.65 10.0 3.8 0.28 11.2 0.2 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding ATP-synt_A PF00119.20 CDW55158.1 - 4.5e-56 190.1 21.6 5.4e-56 189.9 21.6 1.0 1 0 0 1 1 1 1 ATP synthase A chain DUF3333 PF11812.8 CDW55158.1 - 0.015 15.5 3.4 2 8.6 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) CHD5 PF04420.14 CDW55158.1 - 0.11 12.4 6.1 0.83 9.5 1.7 2.4 2 0 0 2 2 2 0 CHD5-like protein ATP-synt_B PF00430.18 CDW55159.1 - 5.6e-36 123.5 21.3 6.7e-36 123.3 21.3 1.1 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) FNIP_C PF14638.6 CDW55159.1 - 0.037 13.7 0.3 0.057 13.1 0.1 1.4 2 0 0 2 2 2 0 Folliculin-interacting protein C-terminus ESM4 PF15952.5 CDW55159.1 - 0.038 14.4 4.2 0.055 13.9 4.2 1.4 1 1 0 1 1 1 0 Enhancer of split M4 family V-ATPase_G_2 PF16999.5 CDW55159.1 - 0.04 14.3 27.9 0.043 14.2 27.0 1.6 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit V-ATPase_G PF03179.15 CDW55159.1 - 0.072 13.6 26.1 0.18 12.3 20.1 2.8 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit CRISPR_Cse1 PF09481.10 CDW55159.1 - 1.1 8.3 7.7 1.3 8.0 7.7 1.0 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) RNA_pol_Rpb2_45 PF10385.9 CDW55159.1 - 1.8 8.9 7.6 0.74 10.1 2.1 2.5 2 1 0 2 2 2 0 RNA polymerase beta subunit external 1 domain DivIVA PF05103.13 CDW55159.1 - 1.9 8.6 23.2 7.8 6.6 21.7 2.2 1 1 0 1 1 1 0 DivIVA protein Pinin_SDK_memA PF04696.13 CDW55159.1 - 5.3 7.1 19.6 1.5 8.9 16.2 1.7 1 1 1 2 2 2 0 pinin/SDK/memA/ protein conserved region ATP-synt_ab PF00006.25 CDW55160.1 - 4.8e-74 248.6 0.3 1.9e-73 246.7 0.1 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CDW55160.1 - 7.2e-43 145.9 1.6 1.5e-42 144.9 1.6 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt PF00231.19 CDW55160.1 - 8.9e-14 51.9 1.2 8.9e-14 51.9 1.2 1.9 3 0 0 3 3 3 1 ATP synthase ATP-synt_ab_N PF02874.23 CDW55160.1 - 5e-13 49.4 0.1 1.3e-12 48.1 0.1 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CDW55160.1 - 0.0001 21.8 0.1 0.00018 20.9 0.1 1.4 1 0 0 1 1 1 1 KaiC ATPase_2 PF01637.18 CDW55160.1 - 0.0075 16.2 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea HAS-barrel PF09378.10 CDW55160.1 - 0.019 15.1 0.2 0.079 13.1 0.0 2.2 2 0 0 2 2 2 0 HAS barrel domain ATP-synt_ab PF00006.25 CDW55161.1 - 1.3e-63 214.5 0.0 1.8e-63 214.0 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDW55161.1 - 1.2e-20 73.7 2.5 2.8e-20 72.6 2.5 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain T3SS_ATPase_C PF18269.1 CDW55161.1 - 0.017 15.0 0.4 0.1 12.5 0.4 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain ATP-synt_DE_N PF02823.16 CDW55162.1 - 2.4e-26 91.4 0.1 3.7e-26 90.8 0.1 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain ATP-synt_DE PF00401.20 CDW55162.1 - 8e-14 51.6 6.2 1.1e-13 51.2 6.2 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Hexapep PF00132.24 CDW55163.1 - 1.5e-27 94.3 14.5 1.3e-07 31.0 0.3 5.4 2 1 3 5 5 5 5 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CDW55163.1 - 1.9e-20 73.8 0.9 3.4e-20 73.0 0.2 1.7 2 0 0 2 2 2 1 MobA-like NTP transferase domain NTP_transferase PF00483.23 CDW55163.1 - 1.4e-12 47.7 0.0 2.1e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 CDW55163.1 - 3.3e-09 36.3 18.7 2.4e-06 27.2 0.1 5.5 4 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase IspD PF01128.19 CDW55163.1 - 1.9e-06 27.8 0.1 3.8e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CofC PF01983.16 CDW55163.1 - 0.0014 17.9 0.0 0.0026 17.0 0.0 1.4 1 0 0 1 1 1 1 Guanylyl transferase CofC like CTP_transf_3 PF02348.19 CDW55163.1 - 0.0062 16.5 0.0 0.081 12.8 0.0 2.2 1 1 0 1 1 1 1 Cytidylyltransferase Fucokinase PF07959.12 CDW55163.1 - 0.014 14.4 0.0 0.21 10.5 0.1 2.4 2 1 1 3 3 3 0 L-fucokinase DUF4954 PF16314.5 CDW55163.1 - 0.045 11.9 0.3 0.12 10.4 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) Bactofilin PF04519.13 CDW55163.1 - 0.11 12.9 0.0 0.11 12.9 0.0 2.6 3 1 0 3 3 3 0 Polymer-forming cytoskeletal Fucose_iso_C PF02952.17 CDW55163.1 - 0.19 11.4 0.3 0.71 9.6 0.1 2.0 2 0 0 2 2 2 0 L-fucose isomerase, C-terminal domain SIS PF01380.22 CDW55164.1 - 4.1e-68 227.2 0.2 2.3e-34 118.1 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CDW55164.1 - 3.8e-22 78.9 0.1 6.8e-22 78.1 0.1 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDW55164.1 - 4.2e-16 59.0 0.0 7.3e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CDW55164.1 - 4e-06 25.9 0.1 1.9e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 Glutamine amidotransferases class-II PBP_like_2 PF12849.7 CDW55165.1 - 2.3e-61 207.9 6.2 3.1e-61 207.5 6.2 1.1 1 0 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 CDW55165.1 - 1.8e-11 43.5 0.0 3.4e-11 42.6 0.0 1.6 1 1 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 CDW55165.1 - 0.0025 17.6 0.0 0.0034 17.2 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein PhoU PF01895.19 CDW55166.1 - 6.4e-37 125.9 9.4 5.3e-19 68.5 1.9 2.7 2 0 0 2 2 2 2 PhoU domain ABC_tran PF00005.27 CDW55166.1 - 4.6e-34 117.9 0.0 1.4e-33 116.3 0.0 1.8 2 0 0 2 2 2 1 ABC transporter BPD_transp_1 PF00528.22 CDW55166.1 - 2.4e-27 95.9 11.5 2.4e-27 95.9 11.5 2.6 2 1 1 3 3 3 1 Binding-protein-dependent transport system inner membrane component AAA_21 PF13304.6 CDW55166.1 - 1.1e-06 28.7 0.1 0.021 14.7 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDW55166.1 - 2.1e-05 24.4 0.0 3.4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDW55166.1 - 0.00026 21.3 0.0 0.001 19.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW55166.1 - 0.00034 20.3 0.0 0.00075 19.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDW55166.1 - 0.0004 20.3 0.0 0.00091 19.2 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDW55166.1 - 0.00097 19.6 0.0 0.0063 16.9 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CDW55166.1 - 0.0015 19.1 0.1 0.0038 17.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 CDW55166.1 - 0.0016 18.4 0.0 0.0033 17.4 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain SMC_N PF02463.19 CDW55166.1 - 0.0019 17.7 0.0 0.0073 15.8 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain PRK PF00485.18 CDW55166.1 - 0.031 14.0 0.0 0.082 12.6 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 CDW55166.1 - 0.099 12.8 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Glyco_hydro_1 PF00232.18 CDW55167.1 - 5.5e-155 516.2 0.6 6.2e-155 516.0 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.18 CDW55167.1 - 0.00012 21.7 0.0 0.00022 20.8 0.0 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4038 PF13204.6 CDW55167.1 - 0.0018 18.0 0.1 0.0028 17.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Albumin_I_a PF16720.5 CDW55167.1 - 0.0047 16.8 0.0 0.016 15.1 0.0 1.9 2 0 0 2 2 2 1 Albumin I chain a UPF0167 PF03691.14 CDW55168.1 - 6.8e-69 231.1 8.6 7.9e-69 230.9 8.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0167) HAD_2 PF13419.6 CDW55169.1 - 3.7e-21 76.0 0.0 4.3e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW55169.1 - 9.1e-10 39.2 0.1 7.3e-09 36.2 0.1 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW55169.1 - 0.0088 16.1 0.2 5 7.3 0.1 2.7 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW55169.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Xan_ur_permease PF00860.20 CDW55170.1 - 1.5e-42 145.7 51.9 1.5e-42 145.7 51.9 1.8 1 1 1 2 2 2 2 Permease family FMN_red PF03358.15 CDW55171.1 - 8e-32 110.1 0.0 9.6e-32 109.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CDW55171.1 - 4.7e-08 33.0 0.0 6.5e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold LysR_substrate PF03466.20 CDW55173.1 - 3.5e-16 59.2 0.3 4.6e-16 58.8 0.3 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDW55173.1 - 5.1e-12 45.6 0.0 9.3e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Fe_dep_repress PF01325.19 CDW55173.1 - 0.0041 17.3 0.6 0.0092 16.2 0.6 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain Cro PF09048.10 CDW55173.1 - 0.023 14.7 0.1 0.04 14.0 0.1 1.3 1 0 0 1 1 1 0 Cro DUF746 PF05344.11 CDW55173.1 - 0.032 14.1 0.0 0.082 12.8 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) HTH_5 PF01022.20 CDW55173.1 - 0.046 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CDW55173.1 - 0.11 12.4 0.1 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 MarR family MFS_1 PF07690.16 CDW55174.1 - 8.1e-44 150.0 37.9 8.1e-44 150.0 37.9 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW55174.1 - 9.4e-13 47.8 6.0 9.4e-13 47.8 6.0 2.8 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CDW55174.1 - 6.2e-07 28.2 3.6 6.2e-07 28.2 3.6 1.8 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF3652 PF12372.8 CDW55174.1 - 0.0094 15.8 0.2 4 7.4 0.1 2.5 2 0 0 2 2 2 2 Huntingtin protein region CLN3 PF02487.17 CDW55174.1 - 0.028 13.5 19.1 0.49 9.4 14.9 2.5 2 1 0 2 2 2 0 CLN3 protein MFS_4 PF06779.14 CDW55174.1 - 0.065 12.5 28.8 0.67 9.2 27.8 2.3 1 1 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 CDW55174.1 - 1.6 7.5 15.3 0.046 12.6 0.5 2.9 1 1 1 2 2 2 0 MFS_1 like family DUF3382 PF11862.8 CDW55174.1 - 2 8.7 13.1 0.81 10.0 0.2 4.5 2 2 2 5 5 5 0 Domain of unknown function (DUF3382) FeoB_C PF07664.12 CDW55174.1 - 8.3 6.2 11.8 12 5.6 0.1 4.3 4 0 0 4 4 4 0 Ferrous iron transport protein B C terminus Trp_Tyr_perm PF03222.13 CDW55175.1 - 2.2e-149 497.8 35.6 2.5e-149 497.6 35.6 1.0 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Phage_Coat_Gp8 PF05371.12 CDW55175.1 - 0.1 12.4 0.7 5.9 6.7 0.1 2.6 2 0 0 2 2 2 0 Phage major coat protein, Gp8 Beta_elim_lyase PF01212.21 CDW55176.1 - 6e-90 301.5 0.0 7e-90 301.3 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CDW55176.1 - 0.00011 21.5 0.0 0.0021 17.3 0.0 2.4 2 1 0 2 2 2 1 Aminotransferase class I and II SepSecS PF05889.13 CDW55176.1 - 0.0068 15.1 0.0 0.016 13.9 0.0 1.6 2 0 0 2 2 2 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS MnmE_helical PF12631.7 CDW55177.1 - 3.8e-61 206.8 1.9 4.6e-61 206.6 1.9 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 CDW55177.1 - 1.9e-35 121.6 0.0 7.3e-35 119.8 0.0 2.0 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CDW55177.1 - 1.1e-25 90.0 0.0 8.1e-25 87.1 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW55177.1 - 2.2e-08 33.8 0.0 8.6e-08 31.9 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDW55177.1 - 7e-05 22.9 0.0 0.00073 19.6 0.0 2.2 1 1 1 2 2 2 1 Dynamin family Ras PF00071.22 CDW55177.1 - 0.00014 21.5 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 CDW55177.1 - 0.00019 21.4 0.0 0.0064 16.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CDW55177.1 - 0.00032 20.1 0.0 0.00058 19.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family ABC_tran PF00005.27 CDW55177.1 - 0.0011 19.5 0.0 0.0023 18.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Roc PF08477.13 CDW55177.1 - 0.0016 18.6 0.0 0.0039 17.4 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 CDW55177.1 - 0.0047 17.2 0.1 0.011 16.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain Arf PF00025.21 CDW55177.1 - 0.0071 15.8 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CDW55177.1 - 0.033 13.6 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDW55177.1 - 0.039 13.3 0.0 0.09 12.1 0.0 1.6 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDW55177.1 - 0.14 11.7 0.0 4.8 6.7 0.0 2.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain 60KD_IMP PF02096.20 CDW55178.1 - 1.7e-47 161.4 8.8 2.4e-47 160.9 8.8 1.2 1 0 0 1 1 1 1 60Kd inner membrane protein YidD PF01809.18 CDW55178.1 - 1.1e-19 70.0 0.0 2e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Putative membrane protein insertion efficiency factor DUF2427 PF10348.9 CDW55178.1 - 0.025 14.4 0.6 0.055 13.3 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) DNA_gyraseB PF00204.25 CDW55179.1 - 8.7e-60 201.2 0.1 2.1e-59 199.9 0.1 1.7 2 0 0 2 2 2 1 DNA gyrase B GyrB_insert PF18053.1 CDW55179.1 - 6.2e-56 188.9 0.1 1.2e-55 187.9 0.1 1.5 1 0 0 1 1 1 1 DNA gyrase B subunit insert domain DNA_gyraseB_C PF00986.21 CDW55179.1 - 5e-31 106.7 0.2 1.2e-30 105.5 0.2 1.7 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CDW55179.1 - 2.8e-22 79.3 0.2 7.2e-22 78.0 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDW55179.1 - 2.5e-18 66.2 0.0 6.9e-18 64.8 0.0 1.8 1 0 0 1 1 1 1 Toprim domain HATPase_c_3 PF13589.6 CDW55179.1 - 0.00087 19.1 0.1 0.0023 17.8 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Spindle_Spc25 PF08234.12 CDW55179.1 - 0.12 12.6 0.0 0.35 11.1 0.0 1.8 1 0 0 1 1 1 0 Chromosome segregation protein Spc25 Hydrolase_3 PF08282.12 CDW55180.1 - 1.8e-67 227.8 0.0 2e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDW55180.1 - 6.6e-16 58.6 0.0 3.9e-08 33.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDW55180.1 - 3.6e-09 37.2 4.5 8.2e-07 29.5 4.5 3.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW55180.1 - 0.00012 22.2 0.0 0.0019 18.3 0.0 2.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDW55180.1 - 0.00098 19.3 0.3 0.023 14.8 0.0 2.7 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW55180.1 - 0.0012 19.3 0.8 1.1 9.6 0.0 3.0 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW55180.1 - 0.016 15.3 0.2 0.11 12.6 0.1 2.2 2 0 0 2 2 2 0 HAD-hyrolase-like FCD PF07729.12 CDW55182.1 - 2.6e-25 89.2 9.5 4e-25 88.6 9.5 1.3 1 0 0 1 1 1 1 FCD domain GntR PF00392.21 CDW55182.1 - 2.1e-14 52.9 0.1 5.2e-14 51.7 0.0 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family DUF2673 PF10880.8 CDW55182.1 - 0.015 15.4 0.5 0.23 11.6 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2673) TFIIE_alpha PF02002.17 CDW55182.1 - 0.05 13.5 0.0 0.16 11.9 0.0 1.8 1 1 0 1 1 1 0 TFIIE alpha subunit DGOK PF05035.12 CDW55183.1 - 3.9e-73 245.8 0.0 6.1e-73 245.2 0.0 1.3 1 0 0 1 1 1 1 2-keto-3-deoxy-galactonokinase Aldolase PF01081.19 CDW55183.1 - 1.6e-29 102.7 1.4 5.4e-29 101.0 0.5 2.0 1 1 1 2 2 2 1 KDPG and KHG aldolase TMP-TENI PF02581.17 CDW55183.1 - 0.00021 20.7 0.1 0.0009 18.6 0.1 2.2 1 1 0 1 1 1 1 Thiamine monophosphate synthase MR_MLE_C PF13378.6 CDW55184.1 - 3.1e-54 183.9 0.0 4.1e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CDW55184.1 - 1.3e-30 106.0 0.0 2.4e-30 105.2 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MFS_1 PF07690.16 CDW55185.1 - 8.9e-56 189.3 36.4 8.9e-56 189.3 36.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW55185.1 - 1.6e-07 30.6 28.1 3e-07 29.6 28.1 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MASE3 PF17159.4 CDW55185.1 - 0.033 13.8 0.3 0.033 13.8 0.3 3.2 3 0 0 3 3 3 0 Membrane-associated sensor domain SPC12 PF06645.13 CDW55185.1 - 0.27 11.3 0.1 0.27 11.3 0.1 3.8 4 1 0 4 4 4 0 Microsomal signal peptidase 12 kDa subunit (SPC12) FAD_binding_3 PF01494.19 CDW55186.1 - 5.2e-10 39.1 0.0 8.8e-06 25.2 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CDW55186.1 - 1.9e-05 24.4 0.0 0.003 17.2 0.0 2.0 1 1 1 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDW55186.1 - 3.6e-05 23.0 0.7 0.17 10.9 0.2 2.1 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CDW55186.1 - 0.00057 19.2 0.0 0.00097 18.5 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CDW55186.1 - 0.093 13.0 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 CDW55186.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF3748 PF12566.8 CDW55187.1 - 6.3e-57 190.9 4.5 1.6e-55 186.3 1.1 3.5 4 0 0 4 4 4 1 Protein of unknown function (DUF3748) PD40 PF07676.12 CDW55187.1 - 8.8e-06 25.5 2.7 0.1 12.6 0.1 4.3 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 CDW55187.1 - 3.5e-05 22.7 0.1 0.68 8.6 0.0 4.2 3 2 0 4 4 4 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 CDW55187.1 - 0.015 15.0 1.1 7.4 6.4 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 CDW55187.1 - 0.18 12.7 4.5 47 5.1 0.1 4.3 3 1 1 4 4 4 0 WD domain, G-beta repeat DUF1375 PF07119.12 CDW55188.1 - 7.2e-08 32.7 0.3 1.3e-07 31.9 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1375) HSP20 PF00011.21 CDW55189.1 - 8.7e-41 138.2 0.0 7.5e-20 71.0 0.0 2.1 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW55189.1 - 4.4e-08 32.6 0.0 0.015 14.8 0.0 3.2 2 1 0 2 2 2 2 HSP20-like domain found in ArsA Nepo_coat_N PF03689.15 CDW55189.1 - 0.1 12.6 0.0 1.4 8.9 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain CarbopepD_reg_2 PF13715.6 CDW55189.1 - 0.17 11.9 0.0 19 5.3 0.0 2.3 2 0 0 2 2 2 0 CarboxypepD_reg-like domain Asp-Al_Ex PF06826.12 CDW55190.1 - 3.4e-89 297.0 44.4 1.3e-47 161.7 14.6 2.1 2 0 0 2 2 2 2 Predicted Permease Membrane Region TrkA_C PF02080.21 CDW55190.1 - 1.6e-19 69.5 4.6 8.8e-11 41.5 0.9 2.7 2 0 0 2 2 2 2 TrkA-C domain PTS_EIIC PF02378.18 CDW55191.1 - 8.5e-73 245.2 33.7 8.5e-73 245.2 33.7 1.9 2 0 0 2 2 2 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CDW55191.1 - 7.8e-12 44.5 0.1 1.3e-11 43.8 0.1 1.4 1 0 0 1 1 1 1 phosphotransferase system, EIIB Glyco_hydro_4 PF02056.16 CDW55192.1 - 1.6e-58 197.3 0.0 3.8e-58 196.1 0.0 1.6 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase Glyco_hydro_4C PF11975.8 CDW55192.1 - 7.7e-52 176.4 0.2 1.1e-51 176.0 0.2 1.2 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain Sulfatase PF00884.23 CDW55193.1 - 2.8e-68 230.6 2.4 4.2e-67 226.7 2.4 2.0 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 CDW55193.1 - 1.5e-07 31.6 0.1 2.7e-07 30.8 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) DUF3784 PF12650.7 CDW55194.1 - 0.017 15.3 7.6 0.097 12.9 3.7 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3784) MFS_1 PF07690.16 CDW55194.1 - 0.92 8.4 14.7 0.95 8.3 9.9 2.0 1 1 1 2 2 2 0 Major Facilitator Superfamily DUF202 PF02656.15 CDW55195.1 - 6.4e-10 39.3 1.2 1.3e-09 38.3 1.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) MFS_1 PF07690.16 CDW55196.1 - 1.7e-39 135.7 45.6 1.7e-39 135.7 45.6 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_3 PF05977.13 CDW55196.1 - 1.6e-06 26.8 4.3 1.6e-06 26.8 4.3 1.9 1 1 0 2 2 2 1 Transmembrane secretion effector TRI12 PF06609.13 CDW55196.1 - 2.1e-06 26.5 3.6 2.1e-06 26.5 3.6 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF2530 PF10745.9 CDW55196.1 - 0.0094 16.2 1.0 0.0094 16.2 1.0 3.3 3 1 2 5 5 5 1 Protein of unknown function (DUF2530) TPP_enzyme_N PF02776.18 CDW55197.1 - 4.6e-58 195.6 0.3 2.6e-57 193.2 0.0 2.4 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CDW55197.1 - 1e-48 165.0 0.1 3.3e-48 163.3 0.1 1.9 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CDW55197.1 - 2.6e-46 156.7 0.2 9.6e-46 154.9 0.3 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Response_reg PF00072.24 CDW55197.1 - 4e-24 84.9 0.2 4.5e-23 81.6 0.0 2.8 3 0 0 3 3 3 1 Response regulator receiver domain GerE PF00196.19 CDW55197.1 - 3e-22 77.9 0.1 6e-22 77.0 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family ACT PF01842.25 CDW55197.1 - 4.4e-08 32.8 0.0 3.8e-07 29.8 0.0 2.5 2 0 0 2 2 2 1 ACT domain ACT_5 PF13710.6 CDW55197.1 - 8.7e-08 31.9 1.3 9.9e-08 31.7 0.0 1.8 2 0 0 2 2 1 1 ACT domain Sigma70_r4_2 PF08281.12 CDW55197.1 - 0.00026 20.6 0.1 0.00087 18.9 0.1 1.9 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 CDW55197.1 - 0.0003 20.2 0.0 0.00076 18.8 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.6 CDW55197.1 - 0.0011 19.0 0.0 0.0047 17.0 0.0 2.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDW55197.1 - 0.0014 18.3 0.0 0.0036 17.1 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.6 CDW55197.1 - 0.0032 17.0 0.0 0.01 15.4 0.0 1.9 2 0 0 2 2 1 1 Winged helix-turn-helix DNA-binding HTH_40 PF14493.6 CDW55197.1 - 0.0098 16.3 0.1 0.047 14.1 0.0 2.2 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_38 PF13936.6 CDW55197.1 - 0.01 15.6 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 CDW55197.1 - 0.012 15.6 0.0 0.034 14.2 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn helix Terminase_5 PF06056.12 CDW55197.1 - 0.014 15.2 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_IclR PF09339.10 CDW55197.1 - 0.015 15.0 0.5 0.39 10.6 0.0 2.9 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_7 PF02796.15 CDW55197.1 - 0.018 15.1 0.0 0.067 13.3 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_Tnp_1 PF01527.20 CDW55197.1 - 0.022 15.1 0.1 0.054 13.8 0.1 1.7 1 0 0 1 1 1 0 Transposase CO_dh PF02552.16 CDW55197.1 - 0.022 14.5 0.1 0.042 13.6 0.1 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit HTH_5 PF01022.20 CDW55197.1 - 0.03 14.2 0.0 0.12 12.2 0.0 2.1 2 0 0 2 2 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 CDW55197.1 - 0.089 12.7 0.4 0.53 10.2 0.0 2.5 3 0 0 3 3 2 0 MarR family HTH_AsnC-type PF13404.6 CDW55197.1 - 0.089 12.6 0.1 0.64 9.9 0.0 2.4 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain IF2_N PF04760.15 CDW55197.1 - 0.096 12.5 0.3 6.7 6.6 0.0 3.1 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region Sigma70_ECF PF07638.11 CDW55197.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 ECF sigma factor Sigma70_r4 PF04545.16 CDW55197.1 - 0.12 11.9 0.0 0.28 10.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 XFP_N PF09364.10 CDW55197.1 - 0.18 10.6 0.0 0.3 9.9 0.0 1.2 1 0 0 1 1 1 0 XFP N-terminal domain HisKA_3 PF07730.13 CDW55198.1 - 1.3e-14 54.4 2.7 1.3e-14 54.4 2.7 2.5 2 0 0 2 2 2 1 Histidine kinase MASE1 PF05231.14 CDW55198.1 - 2.9e-12 46.3 39.0 9.3e-12 44.7 39.0 1.9 1 1 0 1 1 1 1 MASE1 HATPase_c PF02518.26 CDW55198.1 - 7.9e-07 29.6 0.2 4.1e-06 27.3 0.2 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF2232 PF09991.9 CDW55198.1 - 0.033 13.4 0.4 0.033 13.4 0.4 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) HATPase_c_2 PF13581.6 CDW55198.1 - 0.059 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain GIT_CC PF16559.5 CDW55198.1 - 0.066 13.1 1.3 0.6 10.0 0.8 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor KxDL PF10241.9 CDW55198.1 - 2.2 8.6 3.9 8.5 6.7 1.9 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein MFS_1 PF07690.16 CDW55199.1 - 1.3e-49 169.0 58.1 2.8e-49 167.9 43.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 CDW55200.1 - 3.8e-33 114.9 29.5 3.8e-33 114.9 29.5 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Adenine_deam_C PF13382.6 CDW55201.1 - 5.9e-56 188.4 0.0 9.2e-56 187.8 0.0 1.2 1 0 0 1 1 1 1 Adenine deaminase C-terminal domain Amidohydro_1 PF01979.20 CDW55201.1 - 3.5e-29 102.2 0.0 1.8e-28 99.8 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDW55201.1 - 2.1e-11 44.0 0.0 8.4e-05 22.2 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family Xan_ur_permease PF00860.20 CDW55202.1 - 9.3e-41 139.8 47.2 1.1e-40 139.5 47.2 1.1 1 0 0 1 1 1 1 Permease family DUF1198 PF06711.11 CDW55203.1 - 1.4e-52 177.5 0.4 2.7e-52 176.6 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1198) MFS_1 PF07690.16 CDW55203.1 - 2.4e-33 115.5 58.7 2.5e-32 112.2 49.2 2.6 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF4199 PF13858.6 CDW55203.1 - 0.015 15.7 4.2 0.015 15.7 4.2 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF4199) TPP_enzyme_M PF00205.22 CDW55203.1 - 0.025 14.3 0.0 0.049 13.4 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain DUF679 PF05078.12 CDW55203.1 - 0.047 13.6 2.2 0.11 12.5 2.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF679) MFS_4 PF06779.14 CDW55203.1 - 0.38 10.0 38.7 0.11 11.8 33.7 2.3 2 1 1 3 3 3 0 Uncharacterised MFS-type transporter YbfB Lipoprotein_9 PF03180.14 CDW55204.1 - 1.1e-92 309.5 0.2 1.2e-92 309.3 0.2 1.0 1 0 0 1 1 1 1 NLPA lipoprotein OpuAC PF04069.12 CDW55204.1 - 0.011 15.4 0.4 0.019 14.6 0.4 1.7 1 1 0 1 1 1 0 Substrate binding domain of ABC-type glycine betaine transport system EamA PF00892.20 CDW55205.1 - 5.3e-43 146.5 44.9 6.3e-22 78.2 22.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family QCR10 PF09796.9 CDW55205.1 - 0.11 12.5 2.5 0.33 11.1 0.5 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) PGPGW PF09656.10 CDW55205.1 - 9.2 5.9 14.0 0.55 9.8 3.4 3.4 3 0 0 3 3 3 0 Putative transmembrane protein (PGPGW) MFS_1 PF07690.16 CDW55206.1 - 3.9e-36 124.7 47.4 6.4e-34 117.4 30.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CDW55206.1 - 7.9e-08 31.5 31.1 6.9e-07 28.5 8.2 3.0 1 1 2 3 3 3 2 MFS_1 like family Nuc_H_symport PF03825.16 CDW55206.1 - 0.019 14.0 20.9 0.054 12.5 20.9 1.8 1 1 0 1 1 1 0 Nucleoside H+ symporter Glyco_hydro_31 PF01055.26 CDW55207.1 - 1.5e-120 403.4 3.9 2.2e-120 402.8 3.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 MFS_2 PF13347.6 CDW55207.1 - 2.7e-102 342.5 38.4 3.3e-102 342.2 38.4 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Gal_mutarotas_2 PF13802.6 CDW55207.1 - 5.1e-16 58.7 0.1 2e-15 56.8 0.1 2.2 1 0 0 1 1 1 1 Galactose mutarotase-like COX7C PF02935.16 CDW55207.1 - 0.35 11.1 0.0 0.35 11.1 0.0 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIIc AsmA PF05170.14 CDW55208.1 - 1.4e-26 93.5 1.5 2.2e-26 92.9 1.5 1.4 1 1 0 1 1 1 1 AsmA family AsmA_2 PF13502.6 CDW55208.1 - 1.3e-06 28.1 9.1 0.0013 18.3 0.2 4.6 4 1 1 5 5 5 2 AsmA-like C-terminal region DUF748 PF05359.11 CDW55208.1 - 2.1e-05 24.7 4.9 0.12 12.6 0.3 5.1 4 2 0 4 4 4 2 Domain of Unknown Function (DUF748) DUF4097 PF13349.6 CDW55208.1 - 0.0028 17.1 0.0 0.62 9.4 0.0 3.2 2 2 1 3 3 3 1 Putative adhesin Xan_ur_permease PF00860.20 CDW55209.1 - 7.7e-98 327.7 38.2 7.5e-69 232.3 13.0 2.2 1 1 1 2 2 2 2 Permease family MFS_MOT1 PF16983.5 CDW55209.1 - 0.031 14.7 1.8 0.031 14.7 1.8 3.4 2 1 1 3 3 3 0 Molybdate transporter of MFS superfamily SprB PF13573.6 CDW55209.1 - 0.034 13.9 0.3 0.069 12.9 0.3 1.5 1 0 0 1 1 1 0 SprB repeat DUF2304 PF10066.9 CDW55209.1 - 2.1 8.6 9.6 3.6 7.9 0.3 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) Claudin_2 PF13903.6 CDW55209.1 - 5.2 6.8 13.1 2.5 7.8 2.8 3.4 3 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction DUF4131 PF13567.6 CDW55209.1 - 9.1 5.9 14.1 0.3 10.7 0.4 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4131) Glt_symporter PF03616.14 CDW55210.1 - 1.6e-164 547.0 24.6 1.8e-164 546.8 24.6 1.0 1 0 0 1 1 1 1 Sodium/glutamate symporter SpoU_methylase PF00588.19 CDW55211.1 - 1.1e-35 122.9 0.1 2e-35 122.0 0.1 1.5 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_methylas_C PF12105.8 CDW55211.1 - 4.3e-24 84.0 0.9 1.2e-23 82.6 0.9 1.8 1 0 0 1 1 1 1 SpoU, rRNA methylase, C-terminal RecG_wedge PF17191.4 CDW55211.1 - 1.9e-20 73.1 0.0 4.3e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 RecG wedge domain Helicase_C PF00271.31 CDW55211.1 - 1.2e-18 67.5 0.0 1.1e-16 61.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW55211.1 - 2.4e-18 66.5 1.0 5.7e-18 65.3 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 CDW55211.1 - 5.7e-11 42.7 0.0 9e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit tRNA_anti-codon PF01336.25 CDW55211.1 - 2.9e-07 30.4 0.0 5.8e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain AAA_30 PF13604.6 CDW55211.1 - 1.1e-05 25.2 1.8 0.00027 20.7 1.8 2.4 1 1 0 1 1 1 1 AAA domain SecA_DEAD PF07517.14 CDW55211.1 - 1.4e-05 24.6 0.0 2.9e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain SNF2_N PF00176.23 CDW55211.1 - 0.01 14.6 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain DUF2075 PF09848.9 CDW55211.1 - 0.04 13.1 0.0 0.064 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 CDW55211.1 - 0.046 13.6 0.1 0.19 11.6 0.1 1.9 2 0 0 2 2 2 0 Helicase HD_4 PF13328.6 CDW55212.1 - 5.3e-42 143.2 0.8 1e-41 142.3 0.8 1.5 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.17 CDW55212.1 - 3.5e-36 124.0 0.5 1e-35 122.5 0.1 2.0 2 0 0 2 2 2 1 Region found in RelA / SpoT proteins TGS PF02824.21 CDW55212.1 - 8.6e-22 77.0 0.0 2.3e-21 75.6 0.0 1.8 1 0 0 1 1 1 1 TGS domain ACT_4 PF13291.6 CDW55212.1 - 8.9e-16 58.3 2.0 3.2e-15 56.5 1.3 2.4 2 0 0 2 2 2 1 ACT domain HD PF01966.22 CDW55212.1 - 7.5e-08 32.6 1.2 3.4e-07 30.5 0.2 2.4 2 0 0 2 2 2 1 HD domain TFIIS_M PF07500.14 CDW55212.1 - 0.041 14.4 4.5 0.041 14.4 0.1 2.8 3 1 0 3 3 3 0 Transcription factor S-II (TFIIS), central domain COX5A PF02284.16 CDW55212.1 - 0.057 13.4 0.1 15 5.6 0.0 2.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Va DUF2007 PF09413.10 CDW55212.1 - 0.09 13.0 0.0 0.75 10.0 0.0 2.6 2 1 0 2 2 2 0 Putative prokaryotic signal transducing protein EMC3_TMCO1 PF01956.16 CDW55212.1 - 0.12 12.1 0.4 0.27 10.9 0.4 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RNA_pol_Rpb6 PF01192.22 CDW55213.1 - 1.2e-15 57.1 0.1 2e-15 56.4 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 Guanylate_kin PF00625.21 CDW55214.1 - 1.1e-71 240.3 0.0 1.3e-71 240.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase MMR_HSR1 PF01926.23 CDW55214.1 - 0.0017 18.4 0.0 0.0038 17.3 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW55214.1 - 0.0017 18.3 0.1 0.0057 16.6 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CDW55214.1 - 0.0018 18.7 0.3 0.0056 17.1 0.3 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDW55214.1 - 0.0045 17.3 0.2 0.019 15.2 0.2 2.1 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CDW55214.1 - 0.0047 17.4 0.0 0.0095 16.5 0.0 1.4 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 CDW55214.1 - 0.011 15.9 0.0 0.048 13.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW55214.1 - 0.034 14.7 0.0 0.083 13.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 CDW55214.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 CDW55214.1 - 0.5 9.9 1.9 6.2 6.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain DNA_ligase_aden PF01653.18 CDW55215.1 - 1.5e-28 99.8 0.0 2e-22 79.7 0.0 2.2 2 0 0 2 2 2 2 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 CDW55215.1 - 2.4e-18 65.8 0.2 5e-18 64.8 0.2 1.5 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain UPF0126 PF03458.13 CDW55216.1 - 5.7e-42 141.5 24.1 1.6e-22 79.2 5.8 2.4 3 0 0 3 3 3 2 UPF0126 domain Glyco_transf_4 PF13439.6 CDW55216.1 - 0.019 15.0 0.2 0.03 14.3 0.2 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 ThrE PF06738.12 CDW55216.1 - 0.58 9.5 12.9 0.071 12.5 5.0 2.4 2 1 0 2 2 2 0 Putative threonine/serine exporter PRiA4_ORF3 PF07929.11 CDW55217.1 - 2.1e-43 148.0 0.0 2.4e-43 147.9 0.0 1.0 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein SSB PF00436.25 CDW55218.1 - 5.2e-10 39.3 0.0 1.9e-09 37.5 0.0 1.7 2 0 0 2 2 2 1 Single-strand binding protein family P22_CoatProtein PF11651.8 CDW55218.1 - 0.0071 15.0 0.1 0.01 14.5 0.1 1.1 1 0 0 1 1 1 1 P22 coat protein - gene protein 5 RecJ_OB PF17768.1 CDW55218.1 - 0.047 13.9 0.0 0.071 13.3 0.0 1.2 1 0 0 1 1 1 0 RecJ OB domain DUF927 PF06048.11 CDW55219.1 - 0.0084 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF927) GIT_CC PF16559.5 CDW55220.1 - 1.9 8.4 3.2 0.62 10.0 0.1 1.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor 2OG-FeII_Oxy_4 PF13661.6 CDW55221.1 - 8.6e-12 45.6 0.2 4.6e-11 43.2 0.0 2.2 2 1 1 3 3 3 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 CDW55221.1 - 5.9e-07 30.3 0.0 1.3e-06 29.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ofd1_CTDD PF10637.9 CDW55221.1 - 6.5e-06 25.7 0.0 0.0004 19.8 0.0 2.0 1 1 1 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term Peptidase_M22 PF00814.25 CDW55222.1 - 1.3e-78 264.4 0.0 1.7e-78 264.1 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family HDOD PF08668.12 CDW55223.1 - 0.0068 15.9 0.0 0.0097 15.4 0.0 1.2 1 0 0 1 1 1 1 HDOD domain HNH_repeat PF18780.1 CDW55223.1 - 0.059 13.2 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Homing endonuclease repeat Ion_trans PF00520.31 CDW55225.1 - 3.7e-07 29.6 14.8 6.7e-07 28.8 14.8 1.4 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 CDW55225.1 - 0.00084 19.5 1.1 0.0022 18.2 1.1 1.8 1 0 0 1 1 1 1 Transient receptor ion channel II PKD_channel PF08016.12 CDW55225.1 - 0.0079 14.9 13.7 0.018 13.7 13.7 1.6 1 1 0 1 1 1 1 Polycystin cation channel NPCC PF08058.11 CDW55225.1 - 2 8.5 6.1 5.2 7.1 0.2 3.4 3 0 0 3 3 3 0 Nuclear pore complex component Jnk-SapK_ap_N PF09744.9 CDW55227.1 - 1.6e-21 77.2 23.6 1.6e-20 73.9 17.7 2.5 2 1 0 2 2 2 1 JNK_SAPK-associated protein-1 RILP PF11461.8 CDW55227.1 - 1.3e-12 47.8 1.0 1.3e-12 47.8 1.0 2.6 2 1 0 2 2 2 1 Rab interacting lysosomal protein WD40_alt PF14077.6 CDW55227.1 - 0.029 14.2 3.9 0.03 14.2 0.6 2.6 2 0 0 2 2 2 0 Alternative WD40 repeat motif DUF5344 PF17279.2 CDW55227.1 - 0.16 12.6 9.5 1.1 9.9 2.7 3.9 2 1 3 5 5 5 0 Family of unknown function (DUF5344) UPF0242 PF06785.11 CDW55227.1 - 0.22 11.6 23.4 0.023 14.8 8.1 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_2 PF07716.15 CDW55227.1 - 0.26 11.4 0.2 0.26 11.4 0.2 4.2 3 2 1 4 4 4 0 Basic region leucine zipper TPR_MLP1_2 PF07926.12 CDW55227.1 - 0.36 10.9 24.1 2.3 8.3 17.3 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein YjcZ PF13990.6 CDW55227.1 - 0.47 9.8 7.6 2.3 7.5 0.7 2.2 2 0 0 2 2 2 0 YjcZ-like protein KxDL PF10241.9 CDW55227.1 - 0.75 10.1 15.4 0.19 12.1 2.0 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein CCDC-167 PF15188.6 CDW55227.1 - 0.85 10.0 27.7 1.3 9.4 2.5 3.4 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 ZapB PF06005.12 CDW55227.1 - 1.5 9.3 26.8 2.4 8.7 0.7 4.3 2 1 1 3 3 3 0 Cell division protein ZapB DUF2203 PF09969.9 CDW55227.1 - 2.4 8.9 13.5 3.2 8.5 0.0 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Tup_N PF08581.10 CDW55227.1 - 2.7 8.3 15.1 2.5 8.5 0.3 2.9 2 1 0 2 2 2 0 Tup N-terminal Shugoshin_N PF07558.11 CDW55227.1 - 3.4 7.6 9.2 8.4 6.3 0.3 3.4 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region GIT_CC PF16559.5 CDW55227.1 - 5.2 7.0 14.2 1.3 9.0 2.1 3.9 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 CDW55227.1 - 6.7 7.1 10.9 2.9 8.3 2.2 3.0 3 0 0 3 3 2 0 TSC-22/dip/bun family Fib_alpha PF08702.10 CDW55227.1 - 7.3 6.8 11.2 9.7 6.4 4.2 2.7 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family HALZ PF02183.18 CDW55227.1 - 7.9 6.8 17.4 7.4 6.9 2.0 4.7 4 1 0 4 4 4 0 Homeobox associated leucine zipper PEN-2 PF10251.9 CDW55228.1 - 9.8e-30 102.8 1.6 1.1e-29 102.7 1.6 1.0 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase Flavodoxin_1 PF00258.25 CDW55229.1 - 1.1e-26 93.8 0.0 4.2e-26 91.9 0.0 1.9 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 CDW55229.1 - 5.1e-22 78.5 0.0 9e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CDW55229.1 - 2.5e-07 31.3 0.0 0.0013 19.4 0.0 2.4 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 CDW55229.1 - 0.023 14.9 0.0 0.042 14.1 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain bZIP_1 PF00170.21 CDW55230.1 - 8.1e-07 29.0 11.8 8.1e-07 29.0 11.8 1.6 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 CDW55230.1 - 1.7e-05 24.8 10.4 3.8e-05 23.7 10.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper Lzipper-MIP1 PF14389.6 CDW55230.1 - 0.0032 17.7 0.6 0.0076 16.5 0.6 1.6 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 bZIP_Maf PF03131.17 CDW55230.1 - 0.013 16.0 9.5 0.025 15.1 9.5 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor NAM-associated PF14303.6 CDW55230.1 - 0.026 15.3 2.4 0.048 14.4 2.4 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain UPF0449 PF15136.6 CDW55230.1 - 0.086 13.3 2.4 0.15 12.5 2.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Rsm22 PF09243.10 CDW55232.1 - 6.7e-62 209.3 0.0 9.2e-62 208.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_25 PF13649.6 CDW55232.1 - 0.0018 18.9 0.0 0.0037 17.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW55232.1 - 0.1 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CDW55232.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Dyp_perox PF04261.12 CDW55233.1 - 1.9e-28 99.5 0.1 6.2e-15 55.0 0.0 2.1 1 1 1 2 2 2 2 Dyp-type peroxidase family TetR_N PF00440.23 CDW55233.1 - 0.14 12.0 0.1 0.36 10.7 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family N2227 PF07942.12 CDW55234.1 - 4.6e-100 334.3 0.0 6.3e-100 333.8 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 CDW55234.1 - 0.00011 22.8 0.0 0.0009 19.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW55234.1 - 0.0004 20.2 0.0 0.0014 18.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW55234.1 - 0.0039 17.9 0.0 0.015 16.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW55234.1 - 0.011 16.4 0.0 0.22 12.3 0.0 2.6 1 1 0 2 2 2 0 Methyltransferase domain OSCP PF00213.18 CDW55234.1 - 0.027 14.6 0.0 0.043 13.9 0.0 1.3 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit Methyltransf_29 PF03141.16 CDW55234.1 - 0.053 12.1 0.0 0.084 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PhoU_div PF01865.16 CDW55234.1 - 0.085 12.2 0.1 8 5.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function DUF47 Snf7 PF03357.21 CDW55235.1 - 3.1e-33 114.8 15.3 3.1e-33 114.8 15.3 1.4 1 1 0 1 1 1 1 Snf7 MCPsignal PF00015.21 CDW55235.1 - 0.01 15.7 8.4 0.01 15.7 8.4 2.2 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain MBR1 PF17058.5 CDW55235.1 - 0.031 14.6 2.4 0.046 14.0 2.4 1.4 1 1 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 DUF4578 PF15147.6 CDW55235.1 - 0.19 12.6 4.5 0.41 11.5 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) phage_tail_N PF08400.10 CDW55235.1 - 1.9 8.5 6.9 0.56 10.2 1.3 2.4 2 1 0 2 2 2 0 Prophage tail fibre N-terminal Prp18 PF02840.15 CDW55235.1 - 2.4 8.2 8.1 3.9 7.5 3.3 2.9 1 1 0 2 2 2 0 Prp18 domain DUF16 PF01519.16 CDW55235.1 - 9.4 6.8 8.4 68 4.0 8.4 2.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 DSPc PF00782.20 CDW55236.1 - 7.1e-20 71.2 0.0 1.2e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DSPn PF14671.6 CDW55236.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half SelR PF01641.18 CDW55237.1 - 1.1e-52 177.2 0.4 1.4e-52 176.9 0.4 1.1 1 0 0 1 1 1 1 SelR domain zinc_ribbon_10 PF10058.9 CDW55237.1 - 0.012 15.3 4.8 0.025 14.3 0.1 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Yippee-Mis18 PF03226.14 CDW55237.1 - 0.077 13.2 2.8 0.27 11.5 2.8 1.8 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly GTP_EFTU PF00009.27 CDW55238.1 - 3.2e-22 79.0 0.1 4.8e-16 58.9 0.0 2.7 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CDW55238.1 - 8.8e-19 67.6 0.0 2.9e-18 65.9 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 CDW55238.1 - 4.3e-16 58.6 0.0 1.1e-15 57.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 CDW55238.1 - 1e-13 51.5 5.0 6.6e-10 39.2 0.1 3.4 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW55238.1 - 0.021 14.9 2.7 0.26 11.4 0.2 3.3 3 1 0 3 3 3 0 50S ribosome-binding GTPase TniB PF05621.11 CDW55238.1 - 0.075 12.4 0.0 0.18 11.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 CDW55238.1 - 0.1 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NOPS PF08075.11 CDW55239.1 - 4.8e-23 81.1 0.6 9e-23 80.2 0.6 1.5 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_1 PF00076.22 CDW55239.1 - 2.8e-18 65.5 0.0 2e-11 43.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW55239.1 - 0.0005 20.1 0.0 0.001 19.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif Elongin_A PF06881.11 CDW55239.1 - 0.025 15.1 0.4 0.025 15.1 0.4 1.8 1 1 1 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A I_LWEQ PF01608.17 CDW55240.1 - 1.6e-47 161.6 9.0 1.6e-47 161.6 9.0 3.4 2 1 1 3 3 3 1 I/LWEQ domain ANTH PF07651.16 CDW55240.1 - 3.4e-20 72.2 0.7 1.4e-13 50.5 0.1 3.7 1 1 1 2 2 2 2 ANTH domain DND1_DSRM PF14709.7 CDW55240.1 - 0.042 14.1 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 DASH_Spc34 PF08657.10 CDW55240.1 - 8.8 6.0 13.5 1.2 8.9 5.2 2.3 2 0 0 2 2 2 0 DASH complex subunit Spc34 AAA_23 PF13476.6 CDW55240.1 - 9.4 6.7 10.8 6.7 7.2 4.5 2.2 2 0 0 2 2 2 0 AAA domain Tmemb_55A PF09788.9 CDW55241.1 - 1.2e-53 181.7 12.7 1.4e-53 181.5 12.7 1.1 1 0 0 1 1 1 1 Transmembrane protein 55A IBR PF01485.21 CDW55241.1 - 0.0015 18.7 2.3 0.0015 18.7 2.3 3.9 1 1 1 2 2 2 1 IBR domain, a half RING-finger domain HypA PF01155.19 CDW55241.1 - 0.35 10.9 0.1 0.35 10.9 0.1 2.7 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-BED PF02892.15 CDW55241.1 - 0.58 10.2 15.9 7.4 6.7 0.3 4.6 2 2 2 4 4 4 0 BED zinc finger Zn_ribbon_SprT PF17283.2 CDW55241.1 - 0.66 9.9 0.1 0.66 9.9 0.1 3.6 4 1 0 4 4 4 0 SprT-like zinc ribbon domain Peptidase_M22 PF00814.25 CDW55242.1 - 2.6e-86 289.7 0.0 3.1e-86 289.5 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CDW55242.1 - 0.088 12.5 0.0 2 8.0 0.0 2.1 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus Abhydrolase_1 PF00561.20 CDW55243.1 - 1.5e-09 37.9 0.0 2.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDW55243.1 - 4.4e-06 26.1 0.0 7.1e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDW55243.1 - 0.00031 21.4 0.1 0.00059 20.5 0.1 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family CPSF_A PF03178.15 CDW55244.1 - 2.3e-75 253.9 0.2 1e-74 251.7 0.0 2.1 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 CDW55244.1 - 3.3e-31 108.5 0.2 6.9e-31 107.4 0.2 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Ion_trans PF00520.31 CDW55245.1 - 5.6e-30 104.4 8.9 8.8e-30 103.7 8.9 1.3 1 0 0 1 1 1 1 Ion transport protein TRP_2 PF08344.11 CDW55245.1 - 1.9e-27 95.2 2.5 5.8e-27 93.7 2.5 1.9 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 CDW55245.1 - 1.1e-10 41.9 0.3 0.00021 21.8 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) PKD_channel PF08016.12 CDW55245.1 - 6.8e-10 38.2 7.7 7.7e-07 28.1 1.2 2.2 2 0 0 2 2 2 2 Polycystin cation channel Ank PF00023.30 CDW55245.1 - 5.3e-09 36.1 0.1 0.00012 22.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 CDW55245.1 - 2.4e-07 31.2 0.1 0.017 15.7 0.1 3.2 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW55245.1 - 9.7e-07 29.0 0.1 0.014 15.7 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW55245.1 - 1.8e-06 27.8 0.6 0.11 13.1 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat RhoGAP PF00620.27 CDW55245.1 - 0.062 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 RhoGAP domain DUF3301 PF11743.8 CDW55245.1 - 0.11 12.2 0.1 0.3 10.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3301) fn3 PF00041.21 CDW55247.1 - 6.2e-70 231.6 28.0 5.9e-11 42.6 0.0 12.2 13 0 0 13 13 13 9 Fibronectin type III domain Ig_3 PF13927.6 CDW55247.1 - 8.8e-42 141.6 14.7 7.1e-12 45.8 0.2 8.0 7 0 0 7 7 7 5 Immunoglobulin domain I-set PF07679.16 CDW55247.1 - 1.3e-35 121.3 0.2 4.6e-10 39.4 0.0 7.6 7 1 0 7 7 6 5 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW55247.1 - 4.9e-34 116.5 1.2 2.7e-10 40.5 0.0 6.8 6 0 0 6 6 6 5 Immunoglobulin domain FXa_inhibition PF14670.6 CDW55247.1 - 1.3e-20 73.4 85.2 8e-09 35.6 9.7 7.1 7 0 0 7 7 5 4 Coagulation Factor Xa inhibitory site Thyroglobulin_1 PF00086.18 CDW55247.1 - 3.3e-18 65.1 18.8 2.5e-16 59.1 3.9 3.4 2 1 1 3 3 3 2 Thyroglobulin type-1 repeat ig PF00047.25 CDW55247.1 - 1.7e-13 50.6 6.7 2.1e-05 24.6 0.0 6.8 8 0 0 8 8 8 3 Immunoglobulin domain C2-set_2 PF08205.12 CDW55247.1 - 1.2e-12 47.7 6.1 0.046 13.8 0.0 6.0 6 0 0 6 6 5 3 CD80-like C2-set immunoglobulin domain cEGF PF12662.7 CDW55247.1 - 1.8e-11 43.7 26.7 0.00022 21.1 0.7 6.4 6 0 0 6 6 6 3 Complement Clr-like EGF-like Ig_C17orf99 PF17736.1 CDW55247.1 - 2.5e-08 33.8 0.0 0.14 12.2 0.0 6.0 6 0 0 6 6 6 1 C17orf99 Ig domain Kunitz_BPTI PF00014.23 CDW55247.1 - 3.6e-06 27.1 4.8 3.6e-06 27.1 4.8 2.3 2 0 0 2 2 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Tissue_fac PF01108.17 CDW55247.1 - 3.6e-06 26.8 3.4 0.077 12.8 0.5 4.9 5 0 0 5 5 5 2 Tissue factor Pur_ac_phosph_N PF16656.5 CDW55247.1 - 6.5e-06 26.6 11.7 1.1 9.8 0.0 7.5 8 0 0 8 8 7 1 Purple acid Phosphatase, N-terminal domain EGF_CA PF07645.15 CDW55247.1 - 8.8e-05 22.6 7.0 8.8e-05 22.6 7.0 5.6 5 0 0 5 5 4 1 Calcium-binding EGF domain CHB_HEX_C_1 PF13290.6 CDW55247.1 - 0.067 13.2 2.1 0.56 10.3 0.7 3.2 2 0 0 2 2 2 0 Chitobiase/beta-hexosaminidase C-terminal domain Filamin PF00630.19 CDW55247.1 - 0.088 13.6 1.2 2.2 9.2 0.0 3.5 3 0 0 3 3 2 0 Filamin/ABP280 repeat V-set PF07686.17 CDW55247.1 - 0.22 11.7 10.0 22 5.2 0.0 6.7 6 1 1 7 7 7 0 Immunoglobulin V-set domain Myotub-related PF06602.14 CDW55248.1 - 3.9e-134 447.0 0.0 5e-134 446.7 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.21 CDW55248.1 - 1.6e-07 31.4 15.3 5.3e-07 29.7 15.3 2.0 1 0 0 1 1 1 1 FYVE zinc finger DSPc PF00782.20 CDW55248.1 - 0.00094 19.0 0.0 0.003 17.4 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CCDC106 PF15794.5 CDW55248.1 - 0.0035 17.1 1.1 0.02 14.6 1.9 1.8 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 106 Y_phosphatase PF00102.27 CDW55248.1 - 0.0037 16.9 0.1 0.0088 15.6 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase GRAM PF02893.20 CDW55248.1 - 0.0062 16.4 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 GRAM domain Y_phosphatase3 PF13350.6 CDW55248.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF5082 PF16888.5 CDW55248.1 - 0.11 12.7 1.7 0.23 11.7 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF919 PF06034.11 CDW55248.1 - 0.14 12.0 0.6 0.44 10.4 0.6 1.8 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Clat_adaptor_s PF01217.20 CDW55249.1 - 7e-18 64.9 0.9 9e-18 64.6 0.9 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_hydro_32N PF00251.20 CDW55249.1 - 0.015 14.9 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain DUF1365 PF07103.11 CDW55249.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1365) CytochromB561_N PF09786.9 CDW55250.1 - 1.6e-63 215.6 1.6 2e-63 215.3 1.6 1.2 1 0 0 1 1 1 1 Cytochrome B561, N terminal ORC2 PF04084.14 CDW55251.1 - 1.5e-59 201.6 0.0 2e-59 201.2 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 Noc2 PF03715.13 CDW55252.1 - 1.4e-40 139.4 2.9 2.7e-27 95.8 0.9 2.0 1 1 1 2 2 2 2 Noc2p family TAFH PF07531.14 CDW55253.1 - 1.4e-10 41.2 0.6 3.3e-10 39.9 0.2 1.8 2 0 0 2 2 2 1 NHR1 homology to TAF Retrotran_gag_2 PF14223.6 CDW55254.1 - 2.4e-11 43.5 0.0 4.2e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type rve PF00665.26 CDW55254.1 - 1.5e-09 38.0 0.0 5.4e-09 36.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CDW55254.1 - 2.7e-06 27.1 0.0 6.7e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain Retrotran_gag_3 PF14244.6 CDW55254.1 - 4.8e-05 23.1 0.0 0.00013 21.6 0.0 1.7 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 CDW55254.1 - 0.0021 18.0 1.0 0.0021 18.0 1.0 2.1 2 0 0 2 2 2 1 Zinc knuckle DUF4219 PF13961.6 CDW55254.1 - 0.015 15.0 0.0 0.04 13.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) zf-CCHC_5 PF14787.6 CDW55254.1 - 1.9 8.3 5.8 6.9 6.5 5.8 1.9 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger Motile_Sperm PF00635.26 CDW55255.1 - 3.2e-11 43.1 0.0 6.7e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain UFC1 PF08694.11 CDW55256.1 - 6e-84 279.3 0.1 6.8e-84 279.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 CDW55256.1 - 0.017 15.4 0.0 0.018 15.3 0.0 1.2 1 0 0 1 1 1 0 RWD domain CBM_14 PF01607.24 CDW55257.1 - 5.8e-05 23.2 3.7 0.00022 21.3 1.3 2.4 2 1 0 2 2 2 1 Chitin binding Peritrophin-A domain TIP120 PF08623.10 CDW55258.1 - 3.7e-53 179.7 9.9 2.7e-51 173.7 0.2 6.2 5 2 2 7 7 7 1 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 CDW55258.1 - 1.4e-13 51.0 13.3 0.12 13.0 0.1 11.3 11 1 1 12 12 12 3 HEAT-like repeat HEAT PF02985.22 CDW55258.1 - 4.7e-10 38.8 38.8 0.064 13.5 0.2 13.7 15 0 0 15 15 15 4 HEAT repeat HEAT_2 PF13646.6 CDW55258.1 - 6.6e-09 36.0 19.8 0.036 14.5 0.1 9.6 10 3 2 12 12 12 2 HEAT repeats DUF3385 PF11865.8 CDW55258.1 - 9.3e-08 32.1 6.1 0.2 11.5 0.0 7.2 5 1 2 7 7 7 2 Domain of unknown function (DUF3385) ParcG PF10274.9 CDW55258.1 - 0.00017 21.8 5.4 1.1 9.3 0.0 5.3 4 1 1 6 6 6 2 Parkin co-regulated protein Cnd1 PF12717.7 CDW55258.1 - 0.0012 18.9 22.2 0.5 10.4 0.1 7.4 6 2 2 8 8 8 2 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 CDW55258.1 - 0.15 11.8 13.1 0.48 10.1 0.1 5.4 4 2 1 5 5 5 0 rRNA processing/ribosome biogenesis Telomere_reg-2 PF10193.9 CDW55258.1 - 0.55 10.7 21.0 4.5 7.8 0.1 7.7 7 3 2 9 9 9 0 Telomere length regulation protein V-ATPase_H_C PF11698.8 CDW55258.1 - 8 6.6 16.1 35 4.5 0.1 6.8 8 1 2 10 10 10 0 V-ATPase subunit H FbpA PF05833.11 CDW55259.1 - 1.6e-38 132.7 15.5 2.9e-38 131.8 15.5 1.4 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 CDW55259.1 - 7.6e-32 110.2 0.0 2.4e-31 108.6 0.0 1.9 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-C PF11923.8 CDW55259.1 - 8.8e-23 80.3 0.0 8.8e-23 80.3 0.0 2.7 3 0 0 3 3 3 1 NFACT protein C-terminal domain DUF4588 PF15251.6 CDW55259.1 - 0.32 10.7 11.9 0.12 12.1 2.3 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4588) SIX1_SD PF16878.5 CDW55261.1 - 1.8e-46 157.2 0.4 1e-45 154.8 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 CDW55261.1 - 1.7e-12 47.0 2.4 3.4e-12 46.0 1.1 2.1 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW55261.1 - 2.1e-10 40.3 1.2 4.7e-10 39.2 1.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain HTH_3 PF01381.22 CDW55261.1 - 0.04 14.0 0.0 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix Homez PF11569.8 CDW55261.1 - 0.064 12.7 0.2 0.23 11.0 0.0 2.0 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez TetR_C_29 PF17938.1 CDW55261.1 - 0.067 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Herpes_UL32 PF06070.11 CDW55261.1 - 2.6 5.7 6.4 0.19 9.5 0.3 1.9 2 0 0 2 2 2 0 Herpesvirus large structural phosphoprotein UL32 PAP_assoc PF03828.19 CDW55262.1 - 2.7e-08 33.9 0.9 2.1e-07 31.1 0.9 2.3 1 1 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDW55262.1 - 0.027 14.8 0.0 0.044 14.1 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase domain Polbeta PF18765.1 CDW55262.1 - 0.11 12.5 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Kelch_4 PF13418.6 CDW55263.1 - 4.4e-33 113.0 3.1 1.8e-07 31.0 0.1 5.9 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.25 CDW55263.1 - 1.4e-29 101.4 6.1 1.5e-07 30.9 0.0 5.7 5 1 0 5 5 5 5 Kelch motif Kelch_2 PF07646.15 CDW55263.1 - 3.5e-29 99.6 9.1 2.9e-07 30.2 0.0 6.1 6 1 1 7 7 7 5 Kelch motif Kelch_6 PF13964.6 CDW55263.1 - 7e-27 92.8 3.1 3.9e-05 23.8 0.0 5.5 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 CDW55263.1 - 7.4e-24 83.3 5.5 6.6e-05 22.8 0.0 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 CDW55263.1 - 1.8e-20 72.7 17.3 3.1e-06 27.3 0.0 6.9 7 1 0 7 7 7 4 Galactose oxidase, central domain ShK PF01549.24 CDW55264.1 - 8.8 7.0 26.6 0.11 13.1 6.9 2.8 3 0 0 3 3 3 0 ShK domain-like Asparaginase PF00710.20 CDW55265.1 - 2.8e-61 206.4 0.0 4.4e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Ank_2 PF12796.7 CDW55265.1 - 2.1e-23 82.7 1.7 5.7e-11 42.9 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Asparaginase_C PF17763.1 CDW55265.1 - 3.2e-22 78.9 0.0 6.1e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_4 PF13637.6 CDW55265.1 - 2.2e-19 69.5 1.0 4e-09 36.8 0.0 4.0 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW55265.1 - 2.3e-14 52.1 1.0 9.6e-05 22.5 0.0 5.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 CDW55265.1 - 7.7e-14 51.6 0.2 1.1e-05 25.6 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CDW55265.1 - 5.2e-12 45.6 0.2 0.00017 21.9 0.0 4.5 3 0 0 3 3 3 2 Ankyrin repeat Pkinase PF00069.25 CDW55266.1 - 2.5e-65 220.4 0.0 3.1e-65 220.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55266.1 - 4.6e-29 101.5 0.0 6.2e-29 101.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW55266.1 - 6.3e-06 25.7 0.3 1.1e-05 25.0 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDW55266.1 - 8.3e-05 22.0 0.0 0.00018 21.0 0.0 1.5 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 CDW55266.1 - 0.00031 20.4 0.2 0.00055 19.6 0.2 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CDW55266.1 - 0.0007 19.6 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDW55266.1 - 0.097 11.6 0.3 0.15 10.9 0.3 1.3 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 CDW55266.1 - 0.13 11.9 0.0 0.27 10.8 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Cnd2 PF05786.14 CDW55267.1 - 2.3e-29 102.7 1.9 1.1e-14 54.1 0.0 3.1 2 1 1 3 3 3 3 Condensin complex subunit 2 TFIIS_C PF01096.18 CDW55268.1 - 6.3e-20 70.7 5.2 6.3e-20 70.7 5.2 2.9 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CDW55268.1 - 0.00012 21.9 1.3 0.00012 21.9 1.3 2.5 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 CDW55268.1 - 0.00022 21.1 8.9 0.012 15.5 1.5 2.5 2 0 0 2 2 2 2 Transposase zinc-ribbon domain C1_1 PF00130.22 CDW55268.1 - 0.0025 17.6 0.6 0.0025 17.6 0.6 2.4 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) TF_Zn_Ribbon PF08271.12 CDW55268.1 - 0.0039 16.7 7.7 0.23 11.0 2.4 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding Ribosomal_S27e PF01667.17 CDW55268.1 - 0.0044 16.7 2.7 0.51 10.1 0.4 2.4 2 0 0 2 2 2 2 Ribosomal protein S27 Baculo_LEF5_C PF11792.8 CDW55268.1 - 0.065 12.9 0.3 0.065 12.9 0.3 2.3 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain PHD PF00628.29 CDW55268.1 - 0.068 13.1 0.6 0.068 13.1 0.6 2.5 2 1 1 3 3 3 0 PHD-finger zf-C4_Topoisom PF01396.19 CDW55268.1 - 0.12 12.2 0.6 0.12 12.2 0.6 2.7 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Redoxin PF08534.10 CDW55268.1 - 0.18 11.5 1.4 9.1 6.0 0.0 2.1 2 0 0 2 2 2 0 Redoxin Auto_anti-p27 PF06677.12 CDW55268.1 - 0.36 11.0 4.7 9.4 6.5 0.9 2.8 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) HypA PF01155.19 CDW55268.1 - 0.46 10.5 4.9 0.88 9.6 3.7 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PhnA_Zn_Ribbon PF08274.12 CDW55268.1 - 0.51 10.3 0.1 0.51 10.3 0.1 2.9 2 2 0 2 2 2 0 PhnA Zinc-Ribbon A2L_zn_ribbon PF08792.10 CDW55268.1 - 0.67 9.7 6.6 1.5 8.6 2.5 2.7 2 1 0 2 2 2 0 A2L zinc ribbon domain VP_N-CPKC PF11475.8 CDW55268.1 - 0.9 9.5 0.1 0.9 9.5 0.1 3.5 3 1 0 3 3 3 0 Virion protein N terminal domain zinc_ribbon_15 PF17032.5 CDW55268.1 - 2.6 8.9 12.2 11 6.8 9.9 2.6 1 1 1 2 2 2 0 zinc-ribbon family DUF1936 PF09151.10 CDW55268.1 - 4.3 7.3 6.4 17 5.4 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1936) zinc_ribbon_2 PF13240.6 CDW55268.1 - 7.2 6.5 9.6 6.5 6.6 0.6 3.2 3 0 0 3 3 3 0 zinc-ribbon domain NAP PF00956.18 CDW55269.1 - 3.2e-29 101.9 11.1 6.1e-25 87.9 3.5 2.7 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) KaiA PF07688.12 CDW55269.1 - 0.08 13.1 0.5 0.13 12.4 0.5 1.3 1 0 0 1 1 1 0 KaiA C-terminal domain Mss4 PF04421.13 CDW55270.1 - 2.9e-20 72.2 0.0 7.5e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 Mss4 protein TPR_1 PF00515.28 CDW55270.1 - 6.2e-20 70.1 1.7 4.3e-07 29.5 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55270.1 - 5.3e-15 54.3 3.5 2.4e-05 24.1 0.0 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDW55270.1 - 3e-12 46.0 0.2 1.1e-06 28.2 0.1 3.2 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 CDW55270.1 - 4.7e-12 45.1 1.1 0.00079 19.4 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat RPAP3_C PF13877.6 CDW55270.1 - 5.5e-09 36.4 0.5 1.6e-08 34.9 0.5 1.8 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_17 PF13431.6 CDW55270.1 - 1.1e-07 31.7 0.1 0.00073 19.7 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW55270.1 - 2.9e-06 27.3 1.4 0.013 15.6 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW55270.1 - 5.8e-05 23.5 2.0 0.011 16.3 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDW55270.1 - 8.4e-05 23.1 3.4 0.067 14.0 0.1 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDW55270.1 - 9.3e-05 23.0 5.1 0.018 15.7 0.3 2.7 2 1 1 3 3 2 2 Tetratricopeptide repeat Med9 PF07544.13 CDW55270.1 - 0.0002 21.4 1.1 0.00047 20.2 1.1 1.7 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 TPR_19 PF14559.6 CDW55270.1 - 0.00022 21.6 1.2 0.014 15.9 0.3 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDW55270.1 - 0.00042 20.5 3.0 0.13 12.6 0.6 3.1 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW55270.1 - 0.0024 18.0 1.3 0.0066 16.7 0.4 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.7 CDW55270.1 - 0.0044 17.1 0.1 0.11 12.6 0.1 2.5 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) Syntaxin_2 PF14523.6 CDW55270.1 - 0.023 15.0 1.1 0.08 13.3 1.1 1.9 1 0 0 1 1 1 0 Syntaxin-like protein EzrA PF06160.12 CDW55270.1 - 0.029 12.6 0.4 0.049 11.8 0.4 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA TPR_10 PF13374.6 CDW55270.1 - 0.051 13.5 2.1 6.6 6.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2397 PF09660.10 CDW55270.1 - 0.06 12.3 0.2 0.12 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) TMCCDC2 PF15844.5 CDW55270.1 - 0.12 12.3 0.5 0.29 11.1 0.5 1.6 2 0 0 2 2 1 0 Transmembrane and coiled-coil domain-containing protein 2 Baculo_PEP_C PF04513.12 CDW55270.1 - 0.16 12.0 4.6 0.1 12.6 2.2 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 PF06818.15 CDW55270.1 - 1.3 9.4 5.2 0.39 11.2 1.9 1.7 2 0 0 2 2 2 0 Fez1 CENP-F_leu_zip PF10473.9 CDW55270.1 - 2.1 8.4 10.7 0.48 10.5 5.8 2.4 3 0 0 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Serpin PF00079.20 CDW55271.1 - 4e-111 371.9 1.3 4.8e-111 371.6 1.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RRM_1 PF00076.22 CDW55272.1 - 7.6e-19 67.3 0.1 1.1e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) His_Phos_2 PF00328.22 CDW55273.1 - 1.3e-21 77.4 0.6 3.2e-09 36.6 0.0 3.1 3 0 0 3 3 3 3 Histidine phosphatase superfamily (branch 2) Fe_hyd_lg_C PF02906.14 CDW55274.1 - 8.4e-29 100.9 0.0 3.9e-24 85.7 0.0 2.2 1 1 1 2 2 2 2 Iron only hydrogenase large subunit, C-terminal domain Peptidase_M50 PF02163.22 CDW55275.1 - 5e-18 65.3 0.0 1.1e-17 64.2 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M50 Nairovirus_M PF07948.11 CDW55275.1 - 0.58 8.3 3.5 0.18 10.0 0.3 1.7 2 0 0 2 2 2 0 Nairovirus M polyprotein-like His_Phos_2 PF00328.22 CDW55276.1 - 7.3e-20 71.7 0.2 7.4e-19 68.3 0.2 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF1304 PF06993.12 CDW55276.1 - 0.034 14.1 3.1 0.036 14.1 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1304) Evr1_Alr PF04777.13 CDW55277.1 - 4.1e-27 94.6 3.3 4.3e-27 94.5 0.5 1.9 2 0 0 2 2 2 1 Erv1 / Alr family SNAD4 PF18750.1 CDW55277.1 - 0.057 13.5 1.1 0.068 13.3 0.2 1.8 1 1 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC4 PF18775.1 CDW55277.1 - 0.081 13.1 1.3 0.13 12.4 0.1 1.9 2 0 0 2 2 2 0 APOBEC4 DEAD PF00270.29 CDW55278.1 - 5.1e-48 163.2 0.0 4.3e-47 160.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW55278.1 - 6.7e-31 106.9 0.0 3.2e-30 104.7 0.0 2.2 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW55278.1 - 0.0041 17.1 0.0 0.011 15.8 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Pkinase PF00069.25 CDW55279.1 - 4.4e-50 170.5 0.0 7e-50 169.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55279.1 - 1.1e-21 77.4 0.0 1.6e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW55279.1 - 0.0029 17.6 0.1 0.0068 16.4 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDW55279.1 - 0.0079 15.8 0.2 0.042 13.4 0.0 2.1 1 1 0 2 2 2 1 Choline/ethanolamine kinase TFIIA_gamma_C PF02751.14 CDW55279.1 - 0.05 13.7 0.1 0.13 12.4 0.1 1.6 1 0 0 1 1 1 0 Transcription initiation factor IIA, gamma subunit Fibrillarin PF01269.17 CDW55280.1 - 3.2e-107 356.8 0.0 3.9e-107 356.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CDW55280.1 - 0.0013 18.5 0.0 0.0018 18.0 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 CDW55280.1 - 0.17 11.5 0.0 0.39 10.3 0.0 1.6 1 1 0 1 1 1 0 16S rRNA methyltransferase RsmB/F PPTA PF01239.22 CDW55281.1 - 1.4e-46 154.9 19.5 9.3e-10 37.9 0.4 5.1 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat PSCyt2 PF07583.11 CDW55281.1 - 3 7.7 5.8 2.6 7.9 0.6 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1549) EGF PF00008.27 CDW55282.1 - 3.2e-12 46.5 168.3 0.0031 17.8 11.9 13.3 13 1 0 13 13 13 10 EGF-like domain EGF_2 PF07974.13 CDW55282.1 - 0.0053 17.1 204.3 0.0075 16.6 9.1 14.1 12 1 0 12 12 12 6 EGF-like domain hEGF PF12661.7 CDW55282.1 - 0.014 16.0 3.9 0.014 16.0 3.9 15.0 13 3 1 14 14 14 0 Human growth factor-like EGF Alfin PF12165.8 CDW55282.1 - 0.11 12.2 5.2 3.1 7.5 0.1 3.3 3 0 0 3 3 3 0 Alfin HECT PF00632.25 CDW55283.1 - 1e-81 274.8 0.0 1.5e-81 274.2 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Aa_trans PF01490.18 CDW55284.1 - 1.9e-76 257.4 27.9 2.4e-76 257.1 27.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein RRM_1 PF00076.22 CDW55285.1 - 1.3e-34 117.8 0.9 2.2e-17 62.6 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW55285.1 - 1e-17 64.0 1.5 5.2e-09 36.1 0.1 2.6 1 1 1 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CDW55285.1 - 1e-08 35.0 0.1 0.0026 17.7 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 CDW55285.1 - 0.00012 21.9 0.1 0.012 15.6 0.1 2.3 2 0 0 2 2 2 1 RL domain PHM7_cyt PF14703.6 CDW55285.1 - 0.011 16.0 2.5 5.3 7.2 2.3 3.3 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF1866 PF08952.11 CDW55285.1 - 0.023 14.5 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) BicD PF09730.9 CDW55286.1 - 6e-116 388.6 78.6 5.9e-82 276.3 17.5 3.8 3 1 0 3 3 3 2 Microtubule-associated protein Bicaudal-D DUF1759 PF03564.15 CDW55286.1 - 0.0017 18.3 5.7 0.0017 18.3 5.7 3.6 4 1 0 4 4 4 1 Protein of unknown function (DUF1759) XPC-binding PF09280.11 CDW55286.1 - 0.072 12.8 0.1 0.072 12.8 0.1 2.6 3 0 0 3 3 3 0 XPC-binding domain MqsA_antitoxin PF15731.5 CDW55286.1 - 0.16 12.0 4.2 0.081 13.0 0.6 2.4 2 0 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA T3SS_LEE_assoc PF13327.6 CDW55286.1 - 0.85 9.6 5.1 4.8 7.2 2.8 2.6 2 0 0 2 2 2 0 Type III secretion system subunit Mce4_CUP1 PF11887.8 CDW55286.1 - 1.7 8.0 10.7 3.1 7.2 1.5 3.6 4 1 0 4 4 4 0 Cholesterol uptake porter CUP1 of Mce4, putative Methyltransf_31 PF13847.6 CDW55287.1 - 6.3e-15 55.3 0.1 8.2e-15 54.9 0.1 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW55287.1 - 3.4e-12 46.9 0.1 1.2e-11 45.2 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW55287.1 - 3.2e-07 30.4 0.0 3.8e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW55287.1 - 3.6e-07 30.8 0.0 5.5e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW55287.1 - 1.5e-06 28.7 0.0 2.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW55287.1 - 3.8e-06 26.6 0.0 5.1e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CDW55287.1 - 6.8e-05 22.4 0.0 8.2e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 CDW55287.1 - 0.00017 21.5 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CDW55287.1 - 0.00094 18.6 0.0 0.0011 18.4 0.0 1.0 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MetW PF07021.12 CDW55287.1 - 0.0022 17.6 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 CDW55287.1 - 0.0042 16.5 0.0 0.005 16.3 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB Pox_MCEL PF03291.16 CDW55287.1 - 0.0054 15.9 0.1 0.0093 15.1 0.1 1.4 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_32 PF13679.6 CDW55287.1 - 0.008 16.2 0.1 0.013 15.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CDW55287.1 - 0.046 13.2 0.0 0.055 12.9 0.0 1.3 1 1 0 1 1 1 0 Putative methyltransferase PBECR4 PF18813.1 CDW55287.1 - 0.053 13.7 0.0 0.086 13.0 0.0 1.4 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease4 Ubie_methyltran PF01209.18 CDW55287.1 - 0.11 11.7 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PWI PF01480.17 CDW55288.1 - 0.028 14.8 0.3 0.077 13.3 0.3 1.7 1 0 0 1 1 1 0 PWI domain MA3 PF02847.17 CDW55288.1 - 0.05 13.6 5.2 0.1 12.6 0.3 2.5 2 1 1 3 3 3 0 MA3 domain SapB_2 PF03489.17 CDW55288.1 - 0.072 13.2 2.9 0.72 10.0 0.1 3.3 3 0 0 3 3 3 0 Saposin-like type B, region 2 SapB_1 PF05184.15 CDW55288.1 - 0.24 11.5 0.1 0.24 11.5 0.1 3.0 3 2 0 3 3 3 0 Saposin-like type B, region 1 C1_1 PF00130.22 CDW55288.1 - 7.4 6.6 8.1 3.9 7.4 1.2 3.1 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Trypsin PF00089.26 CDW55289.1 - 1.3e-08 34.9 0.0 1.4e-07 31.5 0.0 2.0 1 1 0 1 1 1 1 Trypsin DSPc PF00782.20 CDW55290.1 - 6.6e-10 38.9 0.1 1.1e-09 38.2 0.1 1.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW55290.1 - 0.0001 22.0 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW55290.1 - 0.00019 21.5 0.0 0.00024 21.2 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPn PF14671.6 CDW55290.1 - 0.038 14.4 0.1 0.075 13.5 0.0 1.4 2 0 0 2 2 2 0 Dual specificity protein phosphatase, N-terminal half MCM3AP_GANP PF16769.5 CDW55290.1 - 0.13 10.5 0.0 0.17 10.1 0.0 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP Trypsin PF00089.26 CDW55291.1 - 7.4e-34 117.5 0.0 1.7e-33 116.3 0.0 1.6 1 1 0 1 1 1 1 Trypsin Band_7 PF01145.25 CDW55292.1 - 1.8e-26 93.3 0.3 2.4e-26 92.8 0.3 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CDW55292.1 - 0.004 16.9 0.1 0.0059 16.3 0.1 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family Glypican PF01153.19 CDW55293.1 - 5.3e-17 61.9 4.5 2.3e-14 53.1 0.1 2.3 2 0 0 2 2 2 2 Glypican Pkinase PF00069.25 CDW55295.1 - 3.1e-69 233.3 0.0 4.2e-69 232.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55295.1 - 2.4e-52 177.8 0.0 3.5e-52 177.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 CDW55295.1 - 6.4e-22 77.4 3.8 6.4e-22 77.4 3.8 1.9 2 0 0 2 2 2 1 C terminal SARAH domain of Mst1 Pkinase_fungal PF17667.1 CDW55295.1 - 1.3e-08 34.1 0.0 2.2e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDW55295.1 - 0.022 14.1 0.1 0.19 11.0 0.0 2.2 2 1 0 2 2 2 0 Kinase-like Abi_2 PF07751.11 CDW55295.1 - 0.026 14.8 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 Abi-like protein Nore1-SARAH PF16517.5 CDW55295.1 - 0.028 14.3 1.0 0.073 13.0 1.0 1.7 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Kdo PF06293.14 CDW55295.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4952 PF16310.5 CDW55295.1 - 0.11 12.7 0.1 3.1 8.1 0.0 2.3 2 0 0 2 2 2 0 Domian of unknown function (DUF4952) YfcL PF08891.11 CDW55295.1 - 0.17 12.3 0.5 0.62 10.5 0.3 1.9 2 0 0 2 2 2 0 YfcL protein Phage_Mu_Gam PF07352.12 CDW55295.1 - 0.28 11.1 1.8 0.3 11.0 0.3 1.7 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein Pkinase PF00069.25 CDW55296.1 - 3.9e-70 236.2 0.0 5.5e-70 235.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55296.1 - 9.8e-53 179.1 0.0 1.4e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW55296.1 - 0.00025 20.5 0.0 0.021 14.1 0.0 2.7 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 CDW55296.1 - 0.00035 19.5 0.0 0.00077 18.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW55296.1 - 0.025 14.5 0.1 15 5.4 0.0 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF1241 PF06840.11 CDW55296.1 - 0.044 13.4 0.1 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1241) Haspin_kinase PF12330.8 CDW55296.1 - 0.076 11.9 0.0 0.92 8.4 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain LOH1CR12 PF10158.9 CDW55297.1 - 5.7e-13 49.0 0.0 8.1e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Tumour suppressor protein Aa_trans PF01490.18 CDW55298.1 - 1.1e-36 126.4 31.2 1.8e-34 119.2 27.9 2.5 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein Peptidase_M48_N PF16491.5 CDW55298.1 - 0.015 15.2 2.2 0.015 15.2 2.2 2.8 2 0 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices LIN52 PF10044.9 CDW55299.1 - 9.1e-25 87.2 0.1 1.4e-24 86.6 0.1 1.2 1 0 0 1 1 1 1 Retinal tissue protein Melibiase PF02065.18 CDW55299.1 - 0.094 11.6 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Melibiase zf-RING_9 PF13901.6 CDW55299.1 - 0.12 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon DUF3664 PF12406.8 CDW55299.1 - 0.22 12.2 6.4 6.1 7.5 6.5 2.4 1 1 0 1 1 1 0 Surface protein Acyltransferase PF01553.21 CDW55300.1 - 1.1e-17 63.9 0.0 1.8e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CDW55300.1 - 2.5e-11 43.5 0.0 4.8e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus Bax1-I PF01027.20 CDW55301.1 - 7.3e-35 120.7 20.0 8.4e-35 120.5 20.0 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF4191 PF13829.6 CDW55301.1 - 9.1 5.6 8.8 6.2 6.1 2.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4191) IQ PF00612.27 CDW55302.1 - 1e-08 34.2 23.0 0.00049 19.7 4.3 4.6 4 0 0 4 4 4 4 IQ calmodulin-binding motif Lactamase_B_4 PF13691.6 CDW55302.1 - 0.43 10.3 2.2 4.4 7.1 0.2 2.7 1 1 1 2 2 2 0 tRNase Z endonuclease CCM2_C PF16545.5 CDW55302.1 - 3.5 8.2 6.6 3 8.4 0.7 2.2 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology DHFR_1 PF00186.19 CDW55303.1 - 4.9e-30 104.4 0.0 5.6e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrofolate reductase Cyclin_N PF00134.23 CDW55304.1 - 2.5e-12 46.6 0.1 1.1e-09 38.1 0.0 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 CDW55304.1 - 3.5e-05 23.7 0.2 0.03 14.4 0.1 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 CDW55304.1 - 0.0012 19.2 0.0 0.0059 17.0 0.0 2.1 2 0 0 2 2 2 1 Cyclin C-terminal domain Cyclin_C PF02984.19 CDW55304.1 - 0.01 15.9 0.1 0.01 15.9 0.1 3.1 4 0 0 4 4 4 0 Cyclin, C-terminal domain Spt5_N PF11942.8 CDW55304.1 - 0.28 12.2 15.8 0.89 10.6 15.8 1.8 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal zf-NF-X1 PF01422.17 CDW55305.1 - 2.8e-06 27.3 35.0 0.00021 21.3 12.1 16.0 16 2 0 16 16 16 10 NF-X1 type zinc finger Adap_comp_sub PF00928.21 CDW55306.1 - 3.2e-89 298.8 0.1 4.2e-89 298.4 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDW55306.1 - 3.7e-07 30.2 2.5 6.1e-07 29.5 2.5 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Longin PF13774.6 CDW55306.1 - 0.27 11.3 1.4 0.46 10.6 0.6 1.7 2 0 0 2 2 2 0 Regulated-SNARE-like domain Alpha_L_fucos PF01120.17 CDW55307.1 - 5.2e-121 404.4 4.4 6.7e-121 404.0 4.4 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase Fucosidase_C PF16757.5 CDW55307.1 - 3.7e-16 59.5 0.0 8.4e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Alpha-L-fucosidase C-terminal domain Inositol_P PF00459.25 CDW55308.1 - 2.4e-06 27.3 0.0 3.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Inositol monophosphatase family Orn_Arg_deC_N PF02784.16 CDW55309.1 - 2.5e-76 256.3 0.0 3.1e-76 256.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CDW55309.1 - 9.6e-12 45.0 0.0 1.1e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Sec5 PF15469.6 CDW55310.1 - 3.1e-21 76.1 0.0 7e-21 74.9 0.0 1.7 1 1 0 1 1 1 1 Exocyst complex component Sec5 TIG PF01833.24 CDW55310.1 - 9.8e-07 28.8 0.2 2.6e-06 27.4 0.1 1.8 2 0 0 2 2 2 1 IPT/TIG domain Rrp15p PF07890.12 CDW55311.1 - 2.2e-13 50.7 1.5 2.2e-13 50.7 1.5 1.3 2 0 0 2 2 2 1 Rrp15p ExsD PF16806.5 CDW55311.1 - 0.049 13.5 0.3 0.055 13.4 0.3 1.2 1 0 0 1 1 1 0 Antiactivator protein ExsD Rhodanese PF00581.20 CDW55312.1 - 1.9e-10 41.2 0.0 3.3e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain GDP_Man_Dehyd PF16363.5 CDW55313.1 - 1.7e-55 188.7 0.1 5.6e-54 183.8 0.1 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDW55313.1 - 1.3e-51 175.4 0.0 1.6e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CDW55313.1 - 7.8e-12 44.9 0.0 4.1e-07 29.4 0.0 2.3 1 1 1 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 CDW55313.1 - 2.5e-10 39.8 0.0 3.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CDW55313.1 - 3.2e-10 39.6 0.2 4.7e-06 26.0 0.0 2.8 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CDW55313.1 - 9.3e-09 34.8 0.0 1.2e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 CDW55313.1 - 0.064 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family TIL PF01826.17 CDW55314.1 - 2.1e-14 53.5 15.7 2.7e-14 53.1 15.7 1.1 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain His_Phos_1 PF00300.22 CDW55315.1 - 2.4e-13 50.2 0.0 2.3e-12 47.0 0.0 2.3 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Pkinase PF00069.25 CDW55316.1 - 3.5e-21 75.7 0.0 4.9e-16 58.9 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55316.1 - 1.2e-12 47.7 0.0 8e-10 38.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW55316.1 - 0.00048 19.0 0.0 0.00069 18.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase FIST PF08495.10 CDW55316.1 - 0.026 14.5 0.1 0.097 12.7 0.1 1.8 1 1 0 1 1 1 0 FIST N domain ABC1 PF03109.16 CDW55316.1 - 0.04 14.1 0.0 0.079 13.1 0.0 1.4 1 0 0 1 1 1 0 ABC1 family Peptidase_C1 PF00112.23 CDW55317.1 - 8.2e-56 189.5 7.5 9.6e-56 189.3 7.5 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 CDW55317.1 - 0.033 13.0 1.2 0.12 11.1 0.1 1.9 2 0 0 2 2 2 0 Peptidase C1-like family Tim17 PF02466.19 CDW55318.1 - 6.9e-18 65.0 5.0 8.8e-18 64.7 5.0 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family An_peroxidase PF03098.15 CDW55319.1 - 0 1067.2 0.0 6.5e-191 635.5 0.0 3.0 2 1 0 2 2 2 2 Animal haem peroxidase DUF2528 PF10800.8 CDW55319.1 - 0.0044 17.6 0.2 2.4 8.8 0.1 3.0 2 0 0 2 2 2 2 Protein of unknown function (DUF2528) 7tm_1 PF00001.21 CDW55320.1 - 1.2e-53 182.1 1.1 1.8e-53 181.6 1.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW55320.1 - 3.2e-10 39.8 12.3 3.4e-07 29.9 5.0 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW55320.1 - 2.3e-05 24.1 7.4 2.3e-05 24.1 7.4 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 CDW55320.1 - 0.00014 21.3 11.9 0.00025 20.5 3.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srbc PF10316.9 CDW55320.1 - 0.0018 17.8 7.3 0.0036 16.8 7.3 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7tm_4 PF13853.6 CDW55320.1 - 0.0086 15.8 8.7 0.022 14.5 4.9 2.1 2 0 0 2 2 2 1 Olfactory receptor SF3b10 PF07189.11 CDW55321.1 - 1.2e-29 102.2 0.0 1.3e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) zf-NADH-PPase PF09297.11 CDW55322.1 - 0.096 12.4 6.5 0.23 11.2 6.5 1.7 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain zf-Di19 PF05605.12 CDW55322.1 - 0.26 11.6 1.4 21 5.5 0.1 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF1360 PF07098.11 CDW55322.1 - 0.27 11.2 0.2 0.27 11.2 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1360) Zn_Tnp_IS1595 PF12760.7 CDW55322.1 - 2.1 8.4 9.8 0.31 11.0 2.3 2.9 3 0 0 3 3 3 0 Transposase zinc-ribbon domain Tetraspanin PF00335.20 CDW55323.1 - 1.3e-12 47.9 16.4 2.5e-12 47.0 16.5 1.4 1 1 0 1 1 1 1 Tetraspanin family MrpF_PhaF PF04066.13 CDW55323.1 - 0.18 12.2 6.1 0.48 10.9 6.1 1.7 1 0 0 1 1 1 0 Multiple resistance and pH regulation protein F (MrpF / PhaF) Myb_DNA-bind_6 PF13921.6 CDW55324.1 - 3.6e-08 33.5 1.5 1.1e-06 28.8 0.0 3.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CDW55324.1 - 7e-07 29.3 4.0 0.0021 18.2 0.0 5.4 5 1 0 5 5 5 2 Myb-like DNA-binding domain WXG100 PF06013.12 CDW55324.1 - 0.092 13.0 0.4 0.22 11.7 0.4 1.6 1 0 0 1 1 1 0 Proteins of 100 residues with WXG TMPIT PF07851.13 CDW55324.1 - 4.1 6.6 12.8 0.1 11.8 5.3 1.9 2 0 0 2 2 2 0 TMPIT-like protein HLH PF00010.26 CDW55325.1 - 6.5e-10 38.8 0.7 1.3e-09 37.9 0.7 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Acyl_transf_3 PF01757.22 CDW55326.1 - 1.5e-10 40.7 31.3 1.7e-09 37.2 31.3 2.1 1 1 0 1 1 1 1 Acyltransferase family Bromodomain PF00439.25 CDW55327.1 - 2.5e-11 43.5 0.0 9e-11 41.7 0.0 2.0 2 0 0 2 2 2 1 Bromodomain zf-MYND PF01753.18 CDW55327.1 - 0.0005 20.1 19.1 0.0005 20.1 19.1 3.9 3 2 1 4 4 4 2 MYND finger PHD PF00628.29 CDW55327.1 - 0.024 14.5 1.5 0.024 14.5 1.5 3.9 3 1 1 4 4 4 0 PHD-finger Mitofilin PF09731.9 CDW55327.1 - 0.048 12.5 11.1 0.078 11.8 11.1 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Apolipoprotein PF01442.18 CDW55327.1 - 0.075 12.9 7.3 0.18 11.6 7.3 1.6 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 CDW55327.1 - 0.76 9.3 3.5 1.4 8.4 3.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit SWI-SNF_Ssr4 PF08549.10 CDW55327.1 - 1.5 7.3 7.4 0.086 11.5 2.3 1.3 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) Cullin PF00888.22 CDW55328.1 - 9.1e-149 496.9 14.6 1.3e-148 496.4 14.6 1.2 1 0 0 1 1 1 1 Cullin family Glyco_transf_25 PF01755.17 CDW55328.1 - 1.7e-28 99.8 0.0 1.6e-27 96.7 0.0 2.7 3 1 0 3 3 3 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Pkinase PF00069.25 CDW55328.1 - 3.4e-25 88.9 0.0 1e-24 87.3 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Cullin_Nedd8 PF10557.9 CDW55328.1 - 2e-16 59.8 2.2 5.4e-16 58.4 2.2 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain Pkinase_Tyr PF07714.17 CDW55328.1 - 2.5e-12 46.6 0.0 8.7e-12 44.9 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Anp1 PF03452.14 CDW55328.1 - 3.2e-09 36.6 0.0 6.2e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Anp1 Glyco_tranf_2_4 PF13704.6 CDW55328.1 - 3.3e-08 33.9 0.1 1.1e-07 32.2 0.1 2.0 1 0 0 1 1 1 1 Glycosyl transferase family 2 APH PF01636.23 CDW55328.1 - 0.0066 16.4 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family zf-LYAR PF08790.11 CDW55329.1 - 1.6e-13 50.3 3.0 7.6e-13 48.1 0.8 2.6 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger DUF1283 PF06932.11 CDW55329.1 - 0.034 14.3 2.5 0.034 14.3 2.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1283) zf-ACC PF17848.1 CDW55329.1 - 0.06 13.4 1.5 0.13 12.3 0.0 2.4 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-C2H2 PF00096.26 CDW55329.1 - 0.14 12.6 1.5 4.3 8.0 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type Lar_restr_allev PF14354.6 CDW55329.1 - 0.44 11.0 3.6 1.6 9.2 3.6 2.0 1 0 0 1 1 1 0 Restriction alleviation protein Lar C9orf72-like PF15019.6 CDW55330.1 - 1.9e-39 135.7 2.1 8.1e-32 110.7 0.1 2.4 2 1 1 3 3 3 2 C9orf72-like protein family Cyclin_N PF00134.23 CDW55331.1 - 1.1e-27 96.2 0.1 1.8e-27 95.6 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Frtz PF11768.8 CDW55331.1 - 0.065 11.5 0.0 0.093 11.0 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz AAR2 PF05282.11 CDW55333.1 - 1e-86 291.5 0.0 1.2e-86 291.3 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein YrvL PF14184.6 CDW55333.1 - 0.13 12.4 2.4 0.19 11.8 1.5 1.7 2 0 0 2 2 2 0 Regulatory protein YrvL Rep_fac_C PF08542.11 CDW55334.1 - 2.4e-20 72.8 0.7 6.5e-20 71.3 0.3 2.0 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.29 CDW55334.1 - 1.8e-17 64.0 0.1 4.7e-17 62.7 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDW55334.1 - 1.7e-15 57.2 0.1 2.4e-12 46.9 0.1 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 CDW55334.1 - 7.4e-08 32.5 0.0 2.4e-07 30.9 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CDW55334.1 - 2.8e-06 27.6 1.0 0.027 14.7 0.0 2.8 2 1 1 3 3 3 2 AAA domain AAA_14 PF13173.6 CDW55334.1 - 5.3e-06 26.5 0.0 9.7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 CDW55334.1 - 5.7e-06 26.2 0.0 1.3e-05 25.0 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 CDW55334.1 - 2.2e-05 24.4 0.1 0.00031 20.6 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 CDW55334.1 - 7.8e-05 22.9 0.0 0.0002 21.7 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain ResIII PF04851.15 CDW55334.1 - 0.00017 21.7 0.1 0.33 10.9 0.0 2.3 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CDW55334.1 - 0.0002 21.7 0.1 0.008 16.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CDW55334.1 - 0.00063 20.2 0.0 0.003 17.9 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 CDW55334.1 - 0.00067 19.4 0.0 0.0024 17.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 CDW55334.1 - 0.001 18.9 0.9 0.019 14.7 0.1 2.8 2 1 0 3 3 3 1 DEAD/DEAH box helicase DNA_pol3_delta PF06144.13 CDW55334.1 - 0.0013 18.6 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_5 PF07728.14 CDW55334.1 - 0.0016 18.4 0.2 0.0086 16.1 0.2 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CDW55334.1 - 0.0019 18.0 0.1 0.0047 16.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 CDW55334.1 - 0.0023 17.4 0.1 0.075 12.5 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein DNA_pol3_gamma3 PF12169.8 CDW55334.1 - 0.003 17.5 0.0 0.0075 16.2 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III subunits gamma and tau domain III AAA_7 PF12775.7 CDW55334.1 - 0.0049 16.4 0.0 0.0097 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 CDW55334.1 - 0.0075 15.5 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TniB PF05621.11 CDW55334.1 - 0.011 15.2 0.1 1.6 8.1 0.0 2.8 2 1 1 3 3 3 0 Bacterial TniB protein Mg_chelatase PF01078.21 CDW55334.1 - 0.013 14.9 0.2 0.49 9.7 0.0 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Viral_helicase1 PF01443.18 CDW55334.1 - 0.015 15.0 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 CDW55334.1 - 0.017 15.6 0.0 0.9 10.1 0.0 2.7 1 1 1 2 2 2 0 ABC transporter Thioredoxin_6 PF13848.6 CDW55334.1 - 0.033 14.1 0.2 0.21 11.5 0.2 2.2 2 0 0 2 2 2 0 Thioredoxin-like domain AAA_3 PF07726.11 CDW55334.1 - 0.048 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SNF2_N PF00176.23 CDW55334.1 - 0.051 12.3 0.0 0.11 11.2 0.0 1.6 2 0 0 2 2 2 0 SNF2 family N-terminal domain AAA_18 PF13238.6 CDW55334.1 - 0.071 13.7 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDW55334.1 - 0.072 12.7 0.1 0.6 9.7 0.0 2.1 1 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CDW55334.1 - 0.091 12.5 0.1 0.32 10.7 0.1 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 CDW55334.1 - 0.17 12.2 0.0 0.44 10.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain RecR PF02132.15 CDW55334.1 - 0.17 11.5 0.2 0.49 10.0 0.2 1.7 1 0 0 1 1 1 0 RecR protein FMO-like PF00743.19 CDW55335.1 - 2e-57 194.9 0.0 2.2e-41 141.9 0.0 2.0 1 1 1 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CDW55335.1 - 1.4e-14 54.1 0.0 1.1e-11 44.5 0.0 3.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDW55335.1 - 5e-13 48.9 0.0 2.1e-11 43.6 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDW55335.1 - 4.7e-05 23.4 2.0 0.44 10.5 0.1 3.7 2 2 1 3 3 3 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CDW55335.1 - 9.5e-05 22.6 0.0 0.0008 19.6 0.0 2.4 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CDW55335.1 - 0.00015 21.4 0.1 0.23 11.0 0.2 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 CDW55335.1 - 0.00017 20.9 0.0 0.0048 16.1 0.0 2.4 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CDW55335.1 - 0.00019 21.9 0.4 0.0013 19.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDW55335.1 - 0.014 14.1 0.1 0.65 8.6 0.0 2.3 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 CDW55335.1 - 0.1 11.8 0.1 2.2 7.4 0.1 2.2 2 0 0 2 2 2 0 Thi4 family GIDA PF01134.22 CDW55335.1 - 0.14 11.2 0.2 4.4 6.3 0.1 2.6 2 1 1 3 3 3 0 Glucose inhibited division protein A NUC173 PF08161.12 CDW55336.1 - 5.7e-35 120.8 5.0 8.4e-35 120.3 0.1 3.0 3 0 0 3 3 3 1 NUC173 domain Cnd1 PF12717.7 CDW55336.1 - 0.018 15.1 0.4 0.018 15.1 0.4 3.2 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 RB_B PF01857.20 CDW55336.1 - 0.032 14.2 0.1 0.22 11.5 0.2 2.5 2 0 0 2 2 2 0 Retinoblastoma-associated protein B domain Dpy19 PF10034.9 CDW55337.1 - 4.5e-157 524.1 12.0 9.6e-86 288.4 2.6 2.0 1 1 1 2 2 2 2 Q-cell neuroblast polarisation DUF2618 PF10940.8 CDW55337.1 - 0.028 14.2 0.0 0.11 12.3 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2618) LRR_5 PF13306.6 CDW55338.1 - 9.8e-23 80.5 1.9 1e-09 38.5 0.0 3.8 3 1 0 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_8 PF13855.6 CDW55338.1 - 1.8e-07 30.8 0.0 0.34 10.7 0.0 5.4 4 2 3 7 7 7 5 Leucine rich repeat Beta_helix PF13229.6 CDW55338.1 - 0.00025 20.9 11.1 0.3 10.9 0.7 4.3 3 1 1 4 4 4 2 Right handed beta helix region LRRNT PF01462.18 CDW55338.1 - 4.9 6.9 12.7 0.46 10.2 7.0 2.4 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain WD40_4 PF16300.5 CDW55339.1 - 1.1e-13 50.9 0.2 2e-13 50.0 0.2 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 CDW55339.1 - 8.6e-06 26.4 0.5 0.64 11.0 0.1 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55339.1 - 0.0037 17.5 0.0 0.62 10.4 0.0 2.8 1 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 CDW55340.1 - 1.1e-69 234.7 0.0 1.4e-69 234.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55340.1 - 6.2e-36 124.0 0.0 7.9e-36 123.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW55340.1 - 2e-07 30.6 0.1 4.1e-07 29.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW55340.1 - 0.069 12.1 0.0 0.091 11.7 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Reprolysin PF01421.19 CDW55341.1 - 8.8e-32 110.6 0.2 2e-31 109.5 0.2 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 CDW55341.1 - 4.9e-15 55.9 8.8 4.9e-15 55.9 8.8 3.5 3 0 0 3 3 1 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 CDW55341.1 - 2.1e-14 54.0 0.0 4.6e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 CDW55341.1 - 2.9e-11 44.0 14.7 2.9e-11 44.0 14.7 4.3 2 2 1 3 3 2 1 Disintegrin Reprolysin_3 PF13582.6 CDW55341.1 - 1.4e-06 28.9 0.0 2.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 CDW55341.1 - 1.8e-05 25.0 11.7 1.8e-05 25.0 11.7 5.1 5 0 0 5 5 4 1 EGF-like domain Reprolysin_5 PF13688.6 CDW55341.1 - 6.2e-05 23.2 1.3 9.3e-05 22.7 0.1 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CDW55341.1 - 0.006 16.2 0.0 0.0099 15.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like EGF PF00008.27 CDW55341.1 - 0.015 15.6 4.9 0.015 15.6 4.9 5.2 5 1 1 6 6 4 0 EGF-like domain Peptidase_M10 PF00413.24 CDW55341.1 - 0.021 14.7 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Matrixin VP4_haemagglut PF00426.18 CDW55341.1 - 0.08 13.1 0.4 0.19 11.9 0.4 1.6 1 0 0 1 1 1 0 Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain Peptidase_M57 PF12388.8 CDW55341.1 - 1.8 8.1 5.2 1.4 8.5 2.5 2.2 2 1 0 2 2 2 0 Dual-action HEIGH metallo-peptidase SCHIP-1 PF10148.9 CDW55342.1 - 4.6e-49 167.1 14.1 1e-48 166.1 14.1 1.5 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 UBA2_C PF16195.5 CDW55342.1 - 2.7 8.7 7.4 17 6.2 1.2 2.7 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus FAA_hydrolase PF01557.18 CDW55343.1 - 4.5e-52 176.9 0.0 6.9e-52 176.3 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CDW55343.1 - 1.3e-29 102.5 0.0 2.6e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal SH3_9 PF14604.6 CDW55344.1 - 1.7e-27 95.0 0.6 1.1e-13 50.9 0.1 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CDW55344.1 - 1.4e-26 91.8 0.9 8.9e-12 44.4 0.0 3.4 3 0 0 3 3 3 2 SH3 domain SH3_2 PF07653.17 CDW55344.1 - 1.3e-20 72.8 0.9 1e-11 44.3 0.1 2.9 3 0 0 3 3 3 2 Variant SH3 domain SH2 PF00017.24 CDW55344.1 - 2.8e-20 72.2 0.0 4.7e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.11 CDW55344.1 - 3.2e-05 24.1 0.1 0.00023 21.4 0.1 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_10 PF17902.1 CDW55344.1 - 0.0015 18.6 0.1 0.0095 16.0 0.0 2.2 2 0 0 2 2 2 1 SH3 domain SH2_2 PF14633.6 CDW55344.1 - 0.005 16.3 0.0 0.014 14.8 0.0 1.6 1 1 0 1 1 1 1 SH2 domain Actin PF00022.19 CDW55345.1 - 6.2e-81 272.1 0.0 2.3e-79 266.9 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CDW55345.1 - 0.00021 20.2 0.0 0.0011 17.8 0.0 2.1 3 0 0 3 3 3 1 MreB/Mbl protein CPG4 PF15481.6 CDW55346.1 - 0.0003 21.3 27.5 0.0041 17.7 1.6 5.7 5 1 1 6 6 6 3 Chondroitin proteoglycan 4 Peptidase_S8 PF00082.22 CDW55347.1 - 8.6e-39 133.6 3.8 1.5e-38 132.8 3.8 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 CDW55347.1 - 2.2e-26 91.7 0.6 4.3e-26 90.8 0.6 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 CDW55347.1 - 7.3e-20 71.5 2.6 1.4e-19 70.6 2.6 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain Actin PF00022.19 CDW55348.1 - 1.8e-109 366.1 0.0 1.2e-108 363.4 0.0 1.8 1 1 0 1 1 1 1 Actin ATP-synt_D PF01813.17 CDW55349.1 - 6e-75 251.4 1.8 8.4e-75 250.9 1.8 1.2 1 0 0 1 1 1 1 ATP synthase subunit D MAS20 PF02064.15 CDW55350.1 - 2e-25 89.4 0.2 7.2e-25 87.6 0.0 1.9 1 1 1 2 2 2 1 MAS20 protein import receptor LBP_BPI_CETP_C PF02886.17 CDW55351.1 - 0.00029 20.4 6.9 0.0051 16.3 0.8 3.6 2 2 2 4 4 4 2 LBP / BPI / CETP family, C-terminal domain Metallophos PF00149.28 CDW55352.1 - 1e-70 238.4 0.2 5.3e-34 118.5 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Nop PF01798.18 CDW55352.1 - 1.3e-70 237.5 0.0 2e-70 236.8 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 CDW55352.1 - 1.6e-41 142.0 5.0 3.4e-41 141.0 5.0 1.5 1 0 0 1 1 1 1 Prp31 C terminal domain HHH_5 PF14520.6 CDW55352.1 - 0.17 12.5 0.2 1.4 9.6 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain Myosin_head PF00063.21 CDW55353.1 - 2.1e-284 945.0 7.9 2.1e-284 945.0 7.9 2.9 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 CDW55353.1 - 5.3e-149 498.1 249.8 8.1e-149 497.5 249.8 1.2 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 CDW55353.1 - 5.3e-16 58.2 0.5 1.2e-15 57.0 0.5 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain HALZ PF02183.18 CDW55353.1 - 0.0044 17.2 1.6 0.0044 17.2 1.6 11.8 12 3 1 13 13 13 3 Homeobox associated leucine zipper CC2-LZ PF16516.5 CDW55353.1 - 0.0052 17.1 18.5 0.0052 17.1 18.5 13.9 8 5 3 13 13 13 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ATG16 PF08614.11 CDW55353.1 - 2.7 8.2 246.2 1.1 9.5 42.1 10.5 2 1 7 9 9 9 0 Autophagy protein 16 (ATG16) DUF963 PF06131.11 CDW55354.1 - 0.0019 17.6 7.0 0.0019 17.6 7.0 3.4 2 0 0 2 2 2 1 Schizosaccharomyces pombe repeat of unknown function (DUF963) TSC22 PF01166.18 CDW55355.1 - 1.9e-23 82.5 2.2 2.7e-23 82.0 2.2 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family YabA PF06156.13 CDW55355.1 - 0.012 16.3 0.1 0.016 15.8 0.1 1.2 1 0 0 1 1 1 0 Initiation control protein YabA K-box PF01486.17 CDW55355.1 - 0.015 15.4 0.3 0.022 14.9 0.3 1.2 1 0 0 1 1 1 0 K-box region Nnf1 PF03980.14 CDW55355.1 - 0.018 15.4 0.7 0.028 14.8 0.7 1.2 1 0 0 1 1 1 0 Nnf1 ATG16 PF08614.11 CDW55355.1 - 0.023 14.9 1.6 0.033 14.4 1.6 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 CDW55355.1 - 0.03 14.8 0.8 0.045 14.2 0.8 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.15 CDW55355.1 - 0.052 13.3 0.3 0.08 12.7 0.3 1.2 1 0 0 1 1 1 0 Septum formation initiator Spectrin PF00435.21 CDW55355.1 - 0.086 13.3 0.4 0.12 12.9 0.4 1.2 1 0 0 1 1 1 0 Spectrin repeat Peptidase_A22B PF04258.13 CDW55361.1 - 5.5e-23 81.9 9.1 1.8e-11 44.1 0.0 3.4 1 1 2 3 3 3 3 Signal peptide peptidase DUF1033 PF06279.11 CDW55361.1 - 0.092 12.9 0.1 0.5 10.6 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1033) Glyco_hydro_77 PF02446.17 CDW55361.1 - 0.2 10.5 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 4-alpha-glucanotransferase Ras PF00071.22 CDW55362.1 - 8.4e-18 64.5 0.0 2.2e-16 59.9 0.0 2.2 2 0 0 2 2 2 1 Ras family Roc PF08477.13 CDW55362.1 - 0.078 13.2 0.0 6.6 7.0 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 CDW55362.1 - 0.11 12.6 0.1 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain EF-hand_1 PF00036.32 CDW55364.1 - 1.8e-28 95.9 9.9 8.5e-08 31.2 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDW55364.1 - 3.6e-26 91.4 8.1 1.7e-14 54.0 1.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW55364.1 - 3.1e-24 82.8 11.6 2.1e-08 33.5 0.1 4.5 3 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDW55364.1 - 1.2e-19 69.9 6.8 1.3e-07 31.4 1.5 4.1 2 1 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 CDW55364.1 - 1.4e-17 63.8 0.2 7.6e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDW55364.1 - 2.8e-12 45.5 10.4 3.1e-05 23.3 0.3 4.7 4 1 1 5 5 5 3 EF hand EF-hand_4 PF12763.7 CDW55364.1 - 7.5e-06 25.8 2.2 0.00032 20.6 0.1 2.1 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand PHB_acc_N PF07879.11 CDW55364.1 - 0.00055 20.0 0.2 0.21 11.7 0.1 3.1 2 2 1 3 3 3 1 PHB/PHA accumulation regulator DNA-binding domain DUF530 PF04409.12 CDW55364.1 - 0.0018 16.7 0.1 0.0047 15.3 0.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF530) DUF2666 PF10869.8 CDW55364.1 - 0.0043 17.3 1.1 0.13 12.4 0.3 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF2666) DUF952 PF06108.12 CDW55364.1 - 0.007 16.4 0.0 0.029 14.4 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF952) GPHH PF16905.5 CDW55364.1 - 0.039 13.7 0.0 7.2 6.5 0.0 2.6 3 0 0 3 3 3 0 Voltage-dependent L-type calcium channel, IQ-associated Caleosin PF05042.13 CDW55364.1 - 0.044 13.7 1.4 11 5.9 0.3 2.9 1 1 2 3 3 3 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 CDW55364.1 - 0.044 14.1 1.0 1.3 9.3 0.1 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Importin_rep PF18773.1 CDW55364.1 - 0.075 12.7 0.9 7 6.4 0.1 2.3 2 0 0 2 2 2 0 Importin 13 repeat ECH_2 PF16113.5 CDW55364.1 - 0.087 12.3 0.8 0.98 8.8 0.1 2.0 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase bMG3 PF11974.8 CDW55364.1 - 0.15 12.1 0.1 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Bacterial alpha-2-macroglobulin MG3 domain GCV_T PF01571.21 CDW55365.1 - 8.6e-51 172.8 0.0 1.7e-50 171.8 0.0 1.4 1 1 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CDW55365.1 - 8.9e-11 41.6 0.0 2e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.5 CDW55365.1 - 5.4e-10 39.5 0.0 1.2e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain DAO PF01266.24 CDW55365.1 - 1.5e-05 24.8 0.0 2.2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase SoxG PF04268.12 CDW55365.1 - 0.03 14.5 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family DAO PF01266.24 CDW55366.1 - 1.1e-16 61.4 3.7 1.8e-08 34.4 0.1 2.0 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDW55366.1 - 1.6e-07 31.5 0.3 1.6e-07 31.5 0.3 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CDW55366.1 - 2.9e-07 30.0 0.5 4.5e-06 26.1 0.5 2.1 1 1 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CDW55366.1 - 3.1e-05 23.3 1.1 0.00061 19.0 0.8 2.0 1 1 1 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CDW55366.1 - 0.0001 21.2 0.4 0.005 15.6 0.3 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 CDW55366.1 - 0.00018 20.9 0.4 0.00037 19.8 0.2 1.6 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW55366.1 - 0.0022 17.3 0.1 0.012 14.9 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDW55366.1 - 0.0022 17.3 0.4 0.0031 16.8 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 CDW55366.1 - 0.0035 16.3 1.4 0.95 8.2 0.1 2.0 1 1 1 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 CDW55366.1 - 0.0036 17.8 0.7 0.037 14.6 0.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 CDW55366.1 - 0.0099 15.3 0.3 0.07 12.5 0.1 1.9 1 1 1 2 2 2 1 GMC oxidoreductase FAD_oxidored PF12831.7 CDW55366.1 - 0.034 13.5 0.8 0.18 11.2 0.8 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDW55366.1 - 0.062 12.3 0.2 0.092 11.8 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein zf-C2H2_4 PF13894.6 CDW55368.1 - 2.2e-35 118.3 174.5 0.0062 17.3 0.1 23.6 23 0 0 23 23 23 19 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW55368.1 - 6.9e-30 101.8 163.8 0.0015 18.9 1.0 22.4 22 0 0 22 22 22 15 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CDW55368.1 - 8.6e-11 41.8 121.7 0.0014 18.8 0.1 19.7 21 0 0 21 21 21 11 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW55368.1 - 2.5e-10 40.4 141.7 0.0009 19.6 0.3 21.3 23 0 0 23 23 23 11 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 CDW55368.1 - 0.0087 16.7 2.1 0.0087 16.7 2.1 11.8 3 3 7 13 13 13 4 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 CDW55368.1 - 0.06 13.7 0.1 0.06 13.7 0.1 16.1 13 2 4 17 17 17 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 CDW55368.1 - 0.14 11.9 0.1 0.14 11.9 0.1 8.9 11 0 0 11 11 11 0 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 CDW55369.1 - 3.2e-12 46.2 11.1 6.3e-08 32.6 1.0 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW55369.1 - 8e-10 38.7 10.7 1.1e-05 25.9 1.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW55369.1 - 9.4e-09 35.3 16.1 9.5e-06 25.8 0.9 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 CDW55369.1 - 2.1e-06 27.5 10.2 0.004 17.1 1.4 2.7 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW55369.1 - 0.00013 22.2 6.1 0.0074 16.6 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 CDW55369.1 - 0.00031 20.5 4.5 0.16 11.9 0.4 2.4 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2HE PF16278.5 CDW55369.1 - 0.0095 16.4 2.0 0.0095 16.4 2.0 2.1 1 1 1 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 CDW55369.1 - 0.019 14.7 2.6 1.2 9.0 0.3 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-CRD PF17979.1 CDW55369.1 - 0.028 14.5 0.7 0.033 14.3 0.7 1.1 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions zf_UBZ PF18439.1 CDW55369.1 - 0.042 13.4 4.2 0.31 10.6 0.9 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger His_kinase PF06580.13 CDW55369.1 - 0.052 13.9 0.0 0.075 13.4 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase zf-met PF12874.7 CDW55369.1 - 0.056 13.9 3.9 0.084 13.3 0.1 2.7 2 1 1 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDW55369.1 - 0.056 13.8 6.7 2.1 8.7 0.1 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.9 CDW55369.1 - 0.18 12.0 2.6 7 6.9 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) FYVE PF01363.21 CDW55369.1 - 0.33 11.1 5.7 1 9.5 5.7 1.7 1 1 0 1 1 1 0 FYVE zinc finger Spt46 PF17734.1 CDW55369.1 - 0.74 9.6 4.1 0.81 9.5 0.3 2.2 1 1 2 3 3 3 0 Spermatogenesis-associated protein 46 GTP_EFTU PF00009.27 CDW55372.1 - 2.5e-46 157.7 0.0 3.5e-46 157.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW55372.1 - 1.1e-07 32.0 0.0 0.0014 18.7 0.0 2.4 1 1 1 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 CDW55372.1 - 1.7e-06 28.3 0.2 5.7e-06 26.6 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDW55372.1 - 2.7e-06 27.6 1.2 6e-06 26.6 1.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 CDW55372.1 - 0.0085 15.7 0.0 0.23 11.0 0.0 2.4 2 0 0 2 2 2 1 Ras family Roc PF08477.13 CDW55372.1 - 0.009 16.2 0.1 3 8.1 0.0 2.9 1 1 2 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 CDW55372.1 - 0.072 13.0 2.2 17 5.3 0.1 3.3 3 1 0 3 3 3 0 RsgA GTPase COesterase PF00135.28 CDW55373.1 - 1.1e-154 516.1 0.0 1.3e-154 515.9 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW55373.1 - 1.8e-08 34.5 0.0 3.7e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold AChE_tetra PF08674.10 CDW55373.1 - 0.0041 16.8 7.9 0.013 15.2 7.9 1.9 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain UCH PF00443.29 CDW55374.1 - 1.9e-47 161.9 0.4 3.3e-47 161.1 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW55374.1 - 5e-22 78.9 1.0 2.4e-21 76.6 1.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-FPG_IleRS PF06827.14 CDW55374.1 - 0.075 12.9 0.1 0.075 12.9 0.1 4.1 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS zf_UBZ PF18439.1 CDW55374.1 - 0.087 12.4 0.0 0.23 11.1 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger PCI PF01399.27 CDW55375.1 - 5.2e-08 33.3 0.0 3.7e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 PCI domain GDPD PF03009.17 CDW55376.1 - 3.2e-52 177.8 0.0 3.9e-52 177.5 0.0 1.0 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Pkinase_Tyr PF07714.17 CDW55377.1 - 1.9e-80 269.9 0.0 2.4e-80 269.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW55377.1 - 3.8e-47 160.9 0.0 5.5e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.25 CDW55377.1 - 4.2e-22 78.6 0.1 1.3e-21 77.1 0.2 1.8 2 0 0 2 2 2 1 F5/8 type C domain Haspin_kinase PF12330.8 CDW55377.1 - 0.0013 17.8 0.1 0.002 17.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain EGF PF00008.27 CDW55379.1 - 1.1e-07 32.0 25.1 3e-07 30.6 6.4 3.6 2 1 0 2 2 2 2 EGF-like domain hEGF PF12661.7 CDW55379.1 - 3.3e-06 27.5 5.1 3.3e-06 27.5 5.1 3.8 4 0 0 4 4 4 1 Human growth factor-like EGF EGF_2 PF07974.13 CDW55379.1 - 0.00062 20.1 8.1 0.00062 20.1 8.1 2.6 3 0 0 3 3 3 2 EGF-like domain Laminin_EGF PF00053.24 CDW55379.1 - 0.014 15.5 17.3 0.41 10.8 2.9 2.4 1 1 1 2 2 2 0 Laminin EGF domain EGF_CA PF07645.15 CDW55379.1 - 0.017 15.4 3.9 0.017 15.4 3.9 3.1 2 1 0 2 2 2 0 Calcium-binding EGF domain Ribosomal_S2 PF00318.20 CDW55380.1 - 3.5e-39 134.2 0.4 3.5e-20 72.2 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Suf PF05843.14 CDW55381.1 - 5.8e-53 180.8 0.3 3.1e-45 155.4 0.0 5.3 3 2 0 3 3 3 3 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 CDW55381.1 - 0.044 12.9 4.4 0.097 11.8 0.0 3.5 4 1 1 5 5 5 0 NRDE-2, necessary for RNA interference 2OG-FeII_Oxy_2 PF13532.6 CDW55382.1 - 4e-16 59.8 0.0 1.8e-15 57.6 0.0 1.7 1 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 CDW55382.1 - 8.5e-05 23.0 0.1 0.00059 20.3 0.1 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cadherin_C_2 PF16492.5 CDW55383.1 - 0.0097 16.6 0.3 1.7 9.4 0.0 2.3 2 0 0 2 2 2 2 Cadherin cytoplasmic C-terminal Adeno_E4_34 PF04528.13 CDW55383.1 - 0.021 14.7 0.3 0.034 14.0 0.3 1.4 1 0 0 1 1 1 0 Adenovirus early E4 34 kDa protein conserved region Herpes_gE PF02480.16 CDW55383.1 - 0.025 13.3 2.2 0.49 9.1 0.6 2.0 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E SIT PF15330.6 CDW55383.1 - 0.15 12.5 0.0 17 5.9 0.0 2.2 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT CsgG PF03783.14 CDW55384.1 - 0.082 12.2 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Curli production assembly/transport component CsgG DUF3338 PF11819.8 CDW55384.1 - 0.55 10.2 5.2 0.31 11.0 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3338) Rhodanese PF00581.20 CDW55385.1 - 3.1e-28 98.4 0.0 1e-13 51.7 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Neurensin PF14927.6 CDW55385.1 - 0.029 14.1 0.0 0.048 13.4 0.0 1.3 1 0 0 1 1 1 0 Neurensin Orf78 PF06024.12 CDW55385.1 - 0.21 11.9 0.0 0.36 11.2 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) AsmA PF05170.14 CDW55385.1 - 0.53 9.0 1.1 0.77 8.5 1.1 1.1 1 0 0 1 1 1 0 AsmA family zf-C2H2_4 PF13894.6 CDW55387.1 - 3.1e-12 46.2 27.4 0.0016 19.1 2.0 5.5 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW55387.1 - 4.5e-08 33.1 29.2 0.00052 20.3 1.2 5.5 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CDW55387.1 - 3.5e-05 24.0 14.2 0.014 15.7 0.1 5.6 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW55387.1 - 7.8e-05 22.9 12.0 0.33 11.4 0.3 5.1 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CDW55387.1 - 0.013 15.5 0.3 0.013 15.5 0.3 4.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW55387.1 - 0.026 14.9 27.1 4 8.0 2.8 6.3 6 0 0 6 6 6 0 Zinc-finger double domain zf_UBZ PF18439.1 CDW55387.1 - 0.078 12.6 9.9 0.11 12.1 1.0 3.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Evr1_Alr PF04777.13 CDW55387.1 - 1.1 9.8 5.7 0.53 10.8 0.6 2.5 1 1 1 2 2 2 0 Erv1 / Alr family Zn-ribbon_8 PF09723.10 CDW55387.1 - 9 6.5 18.0 4.8 7.4 0.7 4.3 3 1 1 4 4 4 0 Zinc ribbon domain Ku PF02735.16 CDW55388.1 - 5.1e-43 147.2 0.0 8.2e-43 146.5 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 CDW55388.1 - 2.3e-15 56.9 0.0 8.6e-15 55.1 0.0 1.8 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 CDW55388.1 - 4.2e-14 53.0 0.2 1.1e-13 51.7 0.2 1.6 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm Pept_S41_N PF18294.1 CDW55388.1 - 0.074 13.1 1.5 0.14 12.2 0.2 2.1 2 0 0 2 2 2 0 Peptidase S41 N-terminal domain Arg_decarb_HB PF17810.1 CDW55388.1 - 0.14 12.4 0.0 0.52 10.6 0.0 1.9 2 0 0 2 2 2 0 Arginine decarboxylase helical bundle domain TLD PF07534.16 CDW55389.1 - 8.9e-30 103.7 0.0 1.5e-29 103.0 0.0 1.4 1 0 0 1 1 1 1 TLD LysM PF01476.20 CDW55389.1 - 4.6e-09 36.2 0.0 8.3e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 LysM domain GRAM PF02893.20 CDW55389.1 - 0.042 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 GRAM domain Cation_efflux PF01545.21 CDW55390.1 - 1.1e-14 54.7 12.0 1.4e-14 54.3 12.0 1.2 1 0 0 1 1 1 1 Cation efflux family Cation_ATPase_C PF00689.21 CDW55390.1 - 0.045 13.5 2.3 0.11 12.2 2.3 1.7 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF2214 PF09980.9 CDW55390.1 - 0.054 13.3 3.7 0.15 11.8 1.2 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2214) Ldl_recept_a PF00057.18 CDW55391.1 - 1.4e-08 34.8 4.2 2.5e-08 34.0 4.2 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A AWPM-19 PF05512.11 CDW55391.1 - 0.089 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 AWPM-19-like family PSP PF04046.16 CDW55391.1 - 0.1 12.5 0.4 0.28 11.1 0.1 1.9 2 0 0 2 2 2 0 PSP WD40 PF00400.32 CDW55392.1 - 4.1e-11 43.2 7.1 0.008 17.0 0.0 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55392.1 - 7.6e-09 35.8 0.0 0.026 14.8 0.0 3.7 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW55392.1 - 0.01 14.9 0.0 0.081 11.9 0.0 2.0 1 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CDW55392.1 - 0.026 14.5 0.0 0.66 10.0 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat K1377 PF15352.6 CDW55392.1 - 0.076 11.3 4.8 0.11 10.7 4.8 1.1 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy Spectrin PF00435.21 CDW55393.1 - 1.9e-271 880.1 174.4 2.7e-19 69.6 3.0 17.3 17 0 0 17 17 17 17 Spectrin repeat CH PF00307.31 CDW55393.1 - 2.1e-49 166.3 4.7 9.7e-25 86.9 0.0 5.3 4 0 0 4 4 4 2 Calponin homology (CH) domain PH PF00169.29 CDW55393.1 - 1.4e-14 54.5 0.7 1.6e-12 47.9 0.1 3.0 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 CDW55393.1 - 1.2e-13 51.4 0.8 8.6e-13 48.7 0.0 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain CAMSAP_CH PF11971.8 CDW55393.1 - 6.2e-07 29.2 0.1 0.00019 21.2 0.0 2.9 2 0 0 2 2 2 1 CAMSAP CH domain DUF5616 PF18481.1 CDW55393.1 - 0.0057 17.0 0.1 0.086 13.2 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5616) Phage_tail_S PF05069.13 CDW55393.1 - 0.026 14.3 0.6 0.15 11.9 0.0 2.7 2 0 0 2 2 2 0 Phage virion morphogenesis family DNA_pol3_delt_C PF14840.6 CDW55393.1 - 0.14 12.5 4.9 0.1 12.9 0.4 3.1 2 0 0 2 2 2 0 Processivity clamp loader gamma complex DNA pol III C-term LIAS_N PF16881.5 CDW55393.1 - 5.1 7.6 10.3 3.9 7.9 0.1 5.1 4 1 1 5 5 5 0 N-terminal domain of lipoyl synthase of Radical_SAM family DUF587 PF04532.12 CDW55394.1 - 0.0037 16.6 0.0 0.26 10.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF587) Spectrin_like PF18373.1 CDW55394.1 - 0.027 14.5 0.1 0.07 13.2 0.1 1.6 1 0 0 1 1 1 0 Spectrin like domain PSI PF01437.25 CDW55396.1 - 1.1 9.8 8.9 2.3 8.8 8.9 1.5 1 0 0 1 1 1 0 Plexin repeat NHL PF01436.21 CDW55397.1 - 4.2e-29 99.1 20.6 5.1e-10 38.9 0.1 6.4 6 0 0 6 6 6 5 NHL repeat DUF5128 PF17170.4 CDW55397.1 - 1.9e-08 33.9 3.0 2.1e-05 23.8 0.1 3.1 3 0 0 3 3 3 2 6-bladed beta-propeller zf-B_box PF00643.24 CDW55397.1 - 3.5e-08 33.5 5.7 3.5e-08 33.5 5.7 3.8 4 1 0 4 4 3 2 B-box zinc finger zf-RING_UBOX PF13445.6 CDW55397.1 - 6e-07 29.4 9.2 6e-07 29.4 9.2 2.9 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CDW55397.1 - 1e-06 28.5 9.1 1e-06 28.5 9.1 3.2 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDW55397.1 - 3.3e-05 23.7 9.8 3.3e-05 23.7 9.8 3.3 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDW55397.1 - 0.00037 20.6 10.7 0.00037 20.6 10.7 3.9 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CDW55397.1 - 0.0004 20.3 8.4 0.0004 20.3 8.4 3.6 3 0 0 3 3 2 1 zinc-RING finger domain SGL PF08450.12 CDW55397.1 - 0.00096 18.8 0.1 0.6 9.7 0.0 3.2 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region zf-RING_2 PF13639.6 CDW55397.1 - 0.0058 16.9 9.1 0.0058 16.9 9.1 3.5 3 0 0 3 3 2 1 Ring finger domain DUF2316 PF10078.9 CDW55397.1 - 0.18 12.0 1.3 0.49 10.7 1.3 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) Exonuc_VII_L PF02601.15 CDW55397.1 - 1.8 8.1 5.4 2.9 7.4 5.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-Nse PF11789.8 CDW55397.1 - 2.8 7.9 11.2 0.25 11.2 6.1 2.0 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit AICARFT_IMPCHas PF01808.18 CDW55398.1 - 1.4e-82 277.5 0.0 2.1e-82 276.9 0.0 1.2 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CDW55398.1 - 8.1e-12 45.2 0.0 1.7e-11 44.1 0.0 1.6 1 0 0 1 1 1 1 MGS-like domain BING4CT PF08149.11 CDW55398.1 - 0.055 13.3 0.1 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 BING4CT (NUC141) domain Ribosomal_L12_N PF16320.5 CDW55398.1 - 0.14 11.9 0.2 0.38 10.5 0.2 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain GDI PF00996.18 CDW55399.1 - 1.2e-34 119.6 0.1 6e-14 51.4 0.0 3.0 2 1 1 3 3 3 3 GDP dissociation inhibitor NAD_binding_8 PF13450.6 CDW55399.1 - 0.015 15.5 0.0 0.042 14.1 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CDW55399.1 - 0.06 12.4 0.0 0.53 9.3 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein PRNT PF15174.6 CDW55401.1 - 0.095 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Prion-related protein testis-specific WD40 PF00400.32 CDW55402.1 - 2.7e-17 62.8 5.3 2.9e-05 24.7 0.0 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55402.1 - 0.0066 16.7 0.0 16 5.9 0.0 3.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW55402.1 - 0.012 15.5 0.4 4.5 7.1 0.1 2.7 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Glyco_transf_18 PF15024.6 CDW55403.1 - 0.071 11.7 0.7 0.082 11.5 0.7 1.0 1 0 0 1 1 1 0 Glycosyltransferase family 18 Ribosomal_L36 PF00444.18 CDW55404.1 - 2.6e-09 37.1 6.8 3.3e-09 36.8 6.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L36 CDV3 PF15359.6 CDW55405.1 - 2.7e-05 24.7 9.3 0.00062 20.3 0.8 2.9 2 1 0 2 2 2 2 Carnitine deficiency-associated protein 3 EGF_2 PF07974.13 CDW55406.1 - 2.3e-08 34.3 57.4 0.0086 16.4 9.4 4.9 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 CDW55406.1 - 2.1e-06 27.9 44.9 2.3e-05 24.6 8.8 5.8 4 2 0 4 4 4 2 EGF-like domain hEGF PF12661.7 CDW55406.1 - 0.0075 16.9 38.2 0.021 15.5 0.3 6.0 5 1 0 5 5 5 3 Human growth factor-like EGF Dor1 PF04124.12 CDW55407.1 - 2.9e-62 210.3 4.7 3.8e-62 210.0 4.7 1.2 1 0 0 1 1 1 1 Dor1-like family Sec5 PF15469.6 CDW55407.1 - 0.0013 18.5 2.0 0.013 15.3 0.2 2.2 2 0 0 2 2 2 1 Exocyst complex component Sec5 COG7 PF10191.9 CDW55407.1 - 0.0056 15.0 4.5 0.011 14.1 4.5 1.4 1 1 0 1 1 1 1 Golgi complex component 7 (COG7) PPR PF01535.20 CDW55407.1 - 0.023 14.9 0.1 0.16 12.3 0.0 2.5 2 0 0 2 2 2 0 PPR repeat Oxysterol_BP PF01237.18 CDW55408.1 - 3e-81 273.1 0.1 1.7e-73 247.6 0.0 2.2 2 0 0 2 2 2 2 Oxysterol-binding protein PH PF00169.29 CDW55408.1 - 3.7e-06 27.4 0.0 1.1e-05 25.9 0.0 1.8 1 0 0 1 1 1 1 PH domain ABA_GPCR PF12430.8 CDW55409.1 - 3.4e-27 95.4 7.5 8e-27 94.2 7.5 1.6 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 CDW55409.1 - 5.7e-10 39.1 0.0 1.8e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal DUF373 PF04123.13 CDW55409.1 - 7.5 5.9 10.9 9.8 5.5 3.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF373) PH PF00169.29 CDW55410.1 - 2.2e-05 24.9 0.0 4.3e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 PH domain Glyoxalase PF00903.25 CDW55411.1 - 3.8e-23 82.1 0.0 4.9e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CDW55411.1 - 9.2e-09 35.6 0.0 2.4e-08 34.2 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CDW55411.1 - 3.5e-07 31.0 0.0 5.4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CDW55411.1 - 0.031 14.2 0.0 3.6 7.5 0.0 2.3 2 1 0 2 2 2 0 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CDW55411.1 - 0.054 13.6 0.0 0.13 12.4 0.0 1.7 2 0 0 2 2 2 0 Glyoxalase-like domain PIG-X PF08320.12 CDW55411.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 PIG-X / PBN1 TMEM132D_C PF15706.5 CDW55412.1 - 0.0026 17.5 0.1 0.0066 16.2 0.1 1.7 1 0 0 1 1 1 1 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Imm50 PF15594.6 CDW55412.1 - 0.1 12.8 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 50 Amastin PF07344.11 CDW55412.1 - 0.16 11.8 10.4 0.056 13.3 6.3 1.9 2 0 0 2 2 2 0 Amastin surface glycoprotein FxsA PF04186.13 CDW55412.1 - 0.3 11.2 0.0 0.3 11.2 0.0 1.8 3 0 0 3 3 3 0 FxsA cytoplasmic membrane protein SecY PF00344.20 CDW55412.1 - 0.73 9.0 4.7 0.28 10.4 2.3 1.5 1 1 0 1 1 1 0 SecY translocase DUF4064 PF13273.6 CDW55412.1 - 1.4 9.2 6.9 1.2 9.5 1.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) E1-E2_ATPase PF00122.20 CDW55413.1 - 1.1e-45 155.4 3.1 2.2e-45 154.4 0.5 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDW55413.1 - 3.8e-41 140.8 0.0 3.8e-41 140.8 0.0 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CDW55413.1 - 3.1e-21 75.3 0.1 5.6e-21 74.4 0.1 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDW55413.1 - 2.3e-19 70.6 0.1 9.8e-10 39.1 0.0 3.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CDW55413.1 - 4.6e-16 58.2 0.0 8.9e-16 57.3 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CDW55413.1 - 5.8e-06 26.2 1.2 0.00088 19.1 0.5 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW55413.1 - 0.049 14.0 0.0 0.37 11.2 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase 7tm_7 PF08395.12 CDW55413.1 - 0.53 9.4 4.0 0.66 9.1 0.1 2.5 3 0 0 3 3 3 0 7tm Chemosensory receptor Ribosomal_S10 PF00338.22 CDW55414.1 - 3.2e-22 78.6 0.1 3.8e-22 78.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e McrBC PF10117.9 CDW55414.1 - 0.13 11.3 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component HLH PF00010.26 CDW55415.1 - 4e-18 65.1 1.4 2.4e-17 62.6 0.1 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 CDW55415.1 - 0.0036 17.2 0.0 0.0037 17.1 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain OB_NTP_bind PF07717.16 CDW55416.1 - 6.9e-24 84.0 0.1 2e-23 82.5 0.0 1.8 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CDW55416.1 - 2.1e-23 82.7 0.0 4.7e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDW55416.1 - 2.4e-11 43.9 0.0 7.5e-11 42.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW55416.1 - 2e-06 27.7 0.0 4.6e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDW55416.1 - 5.3e-05 23.5 0.1 0.00029 21.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CDW55416.1 - 0.00035 20.9 0.1 0.00077 19.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDW55416.1 - 0.0048 16.6 0.0 0.0095 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 CDW55416.1 - 0.011 15.4 0.5 0.062 12.9 0.5 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 CDW55416.1 - 0.056 12.9 0.0 0.23 11.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 CDW55416.1 - 0.07 13.6 0.2 1 9.9 0.0 2.7 3 0 0 3 3 3 0 ABC transporter AAA_25 PF13481.6 CDW55416.1 - 0.084 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CDW55416.1 - 0.096 12.7 0.0 3.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 CDW55416.1 - 0.14 12.6 0.0 0.37 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Glyco_hydro_63 PF03200.16 CDW55417.1 - 1.1e-191 637.9 2.0 1.3e-191 637.6 2.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 CDW55417.1 - 1.9e-36 126.3 0.1 3.8e-36 125.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 CDW55417.1 - 0.00017 20.5 0.0 0.00031 19.7 0.0 1.3 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 CDW55417.1 - 0.0027 16.7 0.1 0.0059 15.6 0.1 1.5 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase B12D PF06522.11 CDW55417.1 - 0.013 15.3 0.1 0.034 13.9 0.1 1.7 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit CoA_trans PF01144.23 CDW55418.1 - 1.9e-105 351.1 0.0 1.2e-62 211.2 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 CDW55418.1 - 0.00011 22.1 0.1 0.00027 20.9 0.1 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain DUF2053 PF09767.9 CDW55420.1 - 2.7e-40 138.2 4.8 2.6e-39 134.9 4.8 2.0 1 1 0 1 1 1 1 Predicted membrane protein (DUF2053) Aminotran_3 PF00202.21 CDW55421.1 - 4.8e-111 371.3 0.0 5.5e-111 371.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III HSP20 PF00011.21 CDW55422.1 - 3.7e-16 59.1 0.0 5.2e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW55422.1 - 0.0031 17.0 0.0 0.0048 16.4 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA YabP PF07873.11 CDW55422.1 - 0.12 12.1 0.1 0.47 10.3 0.0 1.8 2 0 0 2 2 2 0 YabP family DUF538 PF04398.12 CDW55422.1 - 0.17 12.3 0.0 0.45 11.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF538 WD40 PF00400.32 CDW55423.1 - 4.4e-47 157.1 17.7 9e-06 26.3 1.5 10.8 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55423.1 - 1.8e-20 73.0 0.1 0.00047 20.4 0.0 7.3 2 2 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW55423.1 - 8.1e-11 42.2 0.0 0.35 10.7 0.0 5.2 2 2 3 5 5 5 4 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CDW55423.1 - 0.00014 21.3 0.0 0.38 10.0 0.0 3.5 2 1 1 3 3 3 2 WD40-like domain PD40 PF07676.12 CDW55423.1 - 0.019 14.9 0.2 5.9 7.0 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Fer4_13 PF13370.6 CDW55423.1 - 0.035 14.7 0.1 0.096 13.2 0.1 1.7 1 0 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I Nbas_N PF15492.6 CDW55423.1 - 0.049 13.0 0.0 1.4 8.2 0.0 2.6 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Cu_amine_oxidN1 PF07833.11 CDW55423.1 - 0.23 12.0 1.3 1.9 9.0 0.1 2.7 3 0 0 3 3 3 0 Copper amine oxidase N-terminal domain DUF1077 PF06417.12 CDW55424.1 - 4.7e-43 146.0 1.8 6e-43 145.6 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Clathrin PF00637.20 CDW55425.1 - 7.9e-184 602.9 39.2 1.2e-32 112.8 0.8 8.2 8 1 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 CDW55425.1 - 5.7e-37 124.2 6.1 2.5e-06 27.5 0.1 6.5 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 CDW55425.1 - 6.6e-27 93.2 0.2 3.8e-26 90.8 0.2 2.4 1 0 0 1 1 1 1 Clathrin-H-link Clathrin-link PF09268.10 CDW55425.1 - 3.8e-12 45.3 0.1 4.6e-11 41.9 0.1 2.7 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 CDW55425.1 - 0.00022 20.4 3.9 0.16 10.9 0.0 4.4 4 0 0 4 4 4 2 Coatomer WD associated region TPR_7 PF13176.6 CDW55425.1 - 0.0049 16.8 2.9 0.75 10.0 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55425.1 - 3.7 8.0 5.1 1.9e+02 2.7 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Cation_ATPase_C PF00689.21 CDW55426.1 - 1.4e-33 116.2 2.5 1.4e-33 116.2 2.5 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CDW55426.1 - 1.3e-11 44.5 0.0 2.8e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) ATP_Ca_trans_C PF12424.8 CDW55426.1 - 0.00023 21.6 0.9 0.23 12.0 0.3 3.2 3 0 0 3 3 3 2 Plasma membrane calcium transporter ATPase C terminal E1-E2_ATPase PF00122.20 CDW55426.1 - 0.00055 19.5 1.3 0.0011 18.5 1.3 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Got1 PF04178.12 CDW55427.1 - 3.3e-16 59.7 9.1 4.3e-16 59.3 9.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family EF-hand_1 PF00036.32 CDW55428.1 - 1.2e-40 134.0 16.8 3.3e-10 38.8 0.6 4.5 4 1 1 5 5 5 4 EF hand EF-hand_7 PF13499.6 CDW55428.1 - 2e-34 117.8 7.3 1.7e-17 63.7 2.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDW55428.1 - 1.8e-30 104.5 14.1 1.3e-14 53.8 1.6 4.3 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CDW55428.1 - 4.1e-30 101.1 9.2 2.1e-09 36.6 0.1 4.7 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 CDW55428.1 - 8.2e-21 72.5 13.3 6.7e-06 25.4 0.1 4.7 5 0 0 5 5 5 4 EF hand EF-hand_9 PF14658.6 CDW55428.1 - 7.4e-13 48.6 0.2 2e-06 28.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CDW55428.1 - 2.1e-08 34.0 1.5 0.0025 17.8 0.1 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 CDW55428.1 - 0.00021 22.1 0.3 0.0023 18.8 0.2 2.0 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 CDW55428.1 - 0.0016 18.6 0.2 0.6 10.3 0.0 2.9 1 1 3 4 4 4 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 CDW55428.1 - 0.0019 18.5 0.1 2.5 8.4 0.1 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 CDW55428.1 - 0.002 18.1 0.1 2.1 8.4 0.0 3.4 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 CDW55428.1 - 0.0021 18.1 1.6 0.037 14.1 0.2 2.9 1 1 1 3 3 3 1 Ca2+ insensitive EF hand Orthopox_B11R PF07033.11 CDW55428.1 - 0.011 15.5 1.1 0.64 9.9 0.1 2.3 2 0 0 2 2 2 0 Orthopoxvirus B11R protein Caleosin PF05042.13 CDW55428.1 - 0.013 15.5 2.3 5.9 6.8 0.0 3.6 1 1 3 4 4 4 0 Caleosin related protein p25-alpha PF05517.12 CDW55428.1 - 0.033 14.4 0.5 3.7 7.7 0.0 2.6 1 1 1 2 2 2 0 p25-alpha ExbD PF02472.16 CDW55428.1 - 0.061 13.5 0.1 9.3 6.4 0.0 2.1 2 0 0 2 2 2 0 Biopolymer transport protein ExbD/TolR Phage_TAC_12 PF12363.8 CDW55428.1 - 0.083 13.3 0.4 1.3 9.5 0.1 2.4 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC YqeY PF09424.10 CDW55428.1 - 0.09 12.8 0.7 0.46 10.5 0.5 1.9 1 1 1 2 2 2 0 Yqey-like protein DUF4588 PF15251.6 CDW55428.1 - 0.099 12.4 0.3 0.12 12.2 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) PMBR PF09373.10 CDW55428.1 - 0.11 12.7 0.0 21 5.5 0.0 3.1 3 0 0 3 3 3 0 Pseudomurein-binding repeat Clathrin_H_link PF13838.6 CDW55428.1 - 0.14 12.1 0.1 0.57 10.1 0.1 2.0 2 0 0 2 2 2 0 Clathrin-H-link Peptidase_C65 PF10275.9 CDW55428.1 - 0.59 9.5 3.5 2.5 7.5 2.2 2.3 2 1 1 3 3 3 0 Peptidase C65 Otubain CHZ PF09649.10 CDW55429.1 - 0.011 15.2 0.3 0.028 13.9 0.3 1.7 1 0 0 1 1 1 0 Histone chaperone domain CHZ Got1 PF04178.12 CDW55429.1 - 0.044 14.2 0.9 0.078 13.4 0.9 1.3 1 0 0 1 1 1 0 Got1/Sft2-like family CortBP2 PF09727.9 CDW55430.1 - 1.2e-51 175.4 26.8 1.2e-51 175.4 26.8 2.3 2 0 0 2 2 2 1 Cortactin-binding protein-2 Trm112p PF03966.16 CDW55430.1 - 2.9e-05 24.6 0.8 0.00017 22.1 0.0 2.8 2 0 0 2 2 2 1 Trm112p-like protein DUF3373 PF11853.8 CDW55430.1 - 0.11 11.5 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) Imm6 PF14434.6 CDW55430.1 - 2.1 8.3 4.7 5.4 7.0 0.3 2.6 1 1 1 2 2 2 0 Immunity protein Imm6 RPN7 PF10602.9 CDW55431.1 - 1.5e-54 184.4 2.9 2.4e-54 183.7 2.9 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CDW55431.1 - 4.5e-16 59.3 0.3 2.5e-15 56.9 0.1 2.3 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 CDW55431.1 - 0.041 13.9 0.2 0.088 12.8 0.2 1.6 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family DUF2808 PF10989.8 CDW55431.1 - 0.065 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) CEP44 PF15007.6 CDW55431.1 - 0.088 13.0 2.6 0.83 9.8 0.1 3.0 3 2 0 3 3 3 0 Centrosomal spindle body, CEP44 Peptidase_M16 PF00675.20 CDW55432.1 - 0.044 13.8 0.0 0.098 12.6 0.1 1.5 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) FlgM PF04316.13 CDW55432.1 - 0.11 12.9 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM DSPc PF00782.20 CDW55433.1 - 4.5e-09 36.2 0.1 6.1e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW55433.1 - 4.2e-05 23.2 0.0 5.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW55433.1 - 7.8e-05 22.7 0.0 0.0001 22.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPn PF14671.6 CDW55433.1 - 0.0016 18.9 0.1 0.0022 18.4 0.1 1.2 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half PTPlike_phytase PF14566.6 CDW55433.1 - 0.0055 16.8 0.0 0.008 16.3 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Met_synt_B12 PF02965.17 CDW55434.1 - 4.5e-108 360.9 0.0 6.8e-108 360.3 0.0 1.3 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 CDW55434.1 - 2.6e-79 266.8 0.0 4.5e-79 266.0 0.0 1.4 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 CDW55434.1 - 9.2e-52 176.1 0.2 4.2e-51 174.0 0.1 2.1 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 CDW55434.1 - 4.5e-22 78.3 0.3 1.4e-21 76.7 0.3 2.0 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.19 CDW55434.1 - 1.4e-19 70.3 0.1 1e-18 67.5 0.2 2.4 2 0 0 2 2 2 1 B12 binding domain Guanylate_cyc PF00211.20 CDW55435.1 - 2.9e-38 131.3 0.1 5.4e-38 130.5 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase PF00069.25 CDW55435.1 - 8.9e-08 31.8 0.1 1.6e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55435.1 - 1.1e-05 24.9 0.2 0.013 14.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Methyltransf_31 PF13847.6 CDW55436.1 - 4.8e-41 140.1 0.0 2.9e-26 92.1 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CDW55436.1 - 1.4e-29 103.1 0.0 4.3e-20 72.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CDW55436.1 - 3.4e-29 101.3 0.0 1.3e-17 64.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 CDW55436.1 - 1.1e-26 93.4 0.0 9.9e-18 64.7 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CDW55436.1 - 5.3e-24 84.8 0.0 1.7e-15 57.5 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 CDW55436.1 - 1.6e-20 73.4 0.1 9.8e-12 44.7 0.0 3.0 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family MTS PF05175.14 CDW55436.1 - 1.1e-08 34.8 0.0 6.9e-08 32.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain GidB PF02527.15 CDW55436.1 - 3.3e-08 33.1 0.0 1.8e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 rRNA small subunit methyltransferase G CMAS PF02353.20 CDW55436.1 - 3.6e-08 33.0 0.0 5.9e-07 29.0 0.0 2.2 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 CDW55436.1 - 8.5e-08 32.2 0.0 4.8e-06 26.5 0.0 2.4 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 CDW55436.1 - 2.3e-07 30.5 0.0 2.5e-06 27.1 0.0 2.6 3 0 0 3 3 3 1 Putative methyltransferase DREV PF05219.12 CDW55436.1 - 9.8e-06 24.9 0.0 0.004 16.3 0.0 2.6 2 0 0 2 2 2 1 DREV methyltransferase PrmA PF06325.13 CDW55436.1 - 1.1e-05 25.0 0.0 1.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 CDW55436.1 - 4.7e-05 23.1 0.0 0.0015 18.1 0.0 2.3 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW TehB PF03848.14 CDW55436.1 - 0.00011 21.7 0.0 0.0013 18.2 0.0 2.1 2 0 0 2 2 2 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 CDW55436.1 - 0.00041 20.4 0.0 0.0009 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CDW55436.1 - 0.00053 19.0 0.0 0.0025 16.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) DUF938 PF06080.12 CDW55436.1 - 0.0014 18.5 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_18 PF12847.7 CDW55436.1 - 0.0024 17.8 0.0 0.0065 16.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Pox_MCEL PF03291.16 CDW55436.1 - 0.0032 16.6 0.0 0.0066 15.6 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme Rrf2 PF02082.20 CDW55436.1 - 0.011 16.1 0.0 20 5.6 0.0 3.4 4 0 0 4 4 4 0 Transcriptional regulator BrkDBD PF09607.10 CDW55436.1 - 0.011 15.4 0.0 7.1 6.5 0.0 2.4 2 0 0 2 2 2 0 Brinker DNA-binding domain FtsJ PF01728.19 CDW55436.1 - 0.012 15.8 0.1 0.047 13.8 0.0 2.1 2 1 0 2 2 1 0 FtsJ-like methyltransferase N6_N4_Mtase PF01555.18 CDW55436.1 - 0.023 14.4 0.0 8.4 6.0 0.0 3.1 3 0 0 3 3 3 0 DNA methylase Methyltransf_8 PF05148.15 CDW55436.1 - 0.023 14.5 0.0 14 5.4 0.0 2.9 3 0 0 3 3 3 0 Hypothetical methyltransferase DOT1 PF08123.13 CDW55436.1 - 0.046 13.2 0.0 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_16 PF10294.9 CDW55436.1 - 0.069 12.9 0.0 0.86 9.3 0.0 2.5 3 0 0 3 3 3 0 Lysine methyltransferase Methyltransf_5 PF01795.19 CDW55436.1 - 0.12 11.8 0.0 1.5 8.3 0.0 2.5 3 0 0 3 3 3 0 MraW methylase family TPMT PF05724.11 CDW55436.1 - 0.14 11.8 0.0 0.45 10.1 0.0 1.8 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) HTH_29 PF13551.6 CDW55436.1 - 0.19 11.8 0.7 26 4.9 0.1 2.4 2 0 0 2 2 2 0 Winged helix-turn helix Mon2_C PF16206.5 CDW55438.1 - 2.4e-112 376.6 4.2 1.8e-55 188.5 0.0 2.3 2 0 0 2 2 2 2 C-terminal region of Mon2 protein Vps26 PF03643.15 CDW55438.1 - 6.6e-101 336.9 7.7 7.8e-99 330.1 7.7 2.3 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 DCB PF16213.5 CDW55438.1 - 9.6e-54 181.7 6.1 9.6e-54 181.7 6.1 3.7 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 CDW55438.1 - 4.3e-36 124.2 3.0 4.3e-36 124.2 3.0 4.1 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 CDW55438.1 - 3.2e-05 23.7 0.1 0.0013 18.5 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) HEAT PF02985.22 CDW55438.1 - 0.0013 18.8 1.8 0.49 10.8 0.1 5.0 4 0 0 4 4 4 1 HEAT repeat FYRC PF05965.14 CDW55438.1 - 0.12 12.6 0.4 0.86 9.8 0.1 2.7 3 0 0 3 3 3 0 F/Y rich C-terminus CCDC154 PF15450.6 CDW55438.1 - 0.18 10.3 1.3 6.2 5.2 0.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 154 LSDAT_euk PF18139.1 CDW55439.1 - 7.5e-67 225.5 0.0 1.1e-66 225.0 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 CDW55439.1 - 4.4e-13 48.9 0.0 6.6e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 CDW55439.1 - 3.5e-07 29.7 23.5 6.3e-07 28.9 23.5 1.4 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 CDW55439.1 - 0.014 14.1 7.8 0.024 13.3 7.8 1.3 1 0 0 1 1 1 0 Polycystin cation channel Ank_2 PF12796.7 CDW55439.1 - 0.046 14.3 0.0 0.29 11.8 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) MFS_1 PF07690.16 CDW55440.1 - 3.9e-19 68.8 44.4 2.3e-18 66.3 24.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_transf_8C PF08437.10 CDW55441.1 - 0.23 11.6 0.0 3.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 8 C-terminal Ig_6 PF18452.1 CDW55442.1 - 4.2e-05 23.0 0.0 0.013 15.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 CDW55442.1 - 0.00015 21.9 0.2 0.83 9.9 0.0 2.6 2 1 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 CDW55442.1 - 0.079 13.0 0.0 6.8 6.8 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW55442.1 - 0.18 12.4 0.0 9.4 6.9 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain MFS_1 PF07690.16 CDW55443.1 - 6.4e-31 107.6 49.1 1e-17 64.2 26.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRIQK PF15168.6 CDW55443.1 - 0.84 9.6 2.5 2.8 7.9 1.1 2.5 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family DUF3473 PF11959.8 CDW55444.1 - 0.0099 15.9 0.3 0.077 13.0 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3473) RelB PF04221.12 CDW55444.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 RelB antitoxin PAP2 PF01569.21 CDW55445.1 - 1.6e-10 40.8 2.7 1.6e-10 40.8 2.7 3.0 3 1 0 3 3 3 1 PAP2 superfamily Wzy_C_2 PF11846.8 CDW55445.1 - 0.034 14.1 0.1 0.073 13.0 0.1 1.7 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal Trypsin PF00089.26 CDW55446.1 - 3.1e-32 112.2 0.1 1e-10 41.8 0.0 3.6 3 0 0 3 3 3 3 Trypsin DUF316 PF03761.15 CDW55446.1 - 0.049 13.2 0.0 0.22 11.1 0.0 1.9 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 DUF3473 PF11959.8 CDW55447.1 - 0.011 15.8 0.5 0.055 13.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3473) COE1_DBD PF16422.5 CDW55448.1 - 1.1e-132 440.6 3.0 1.5e-132 440.1 3.0 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.5 CDW55448.1 - 4.7e-30 103.0 0.5 9.3e-30 102.1 0.5 1.5 1 0 0 1 1 1 1 Transcription factor COE1 helix-loop-helix domain TIG PF01833.24 CDW55448.1 - 3.8e-11 42.9 1.5 7.8e-11 41.9 0.1 2.2 2 0 0 2 2 2 1 IPT/TIG domain HLH PF00010.26 CDW55448.1 - 0.027 14.4 0.0 0.053 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Ribosomal_L28e PF01778.17 CDW55449.1 - 1.4e-29 103.1 0.0 3.2e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 CDW55449.1 - 1.4e-22 80.1 5.7 1.4e-22 80.1 5.7 1.7 2 0 0 2 2 2 1 Mak16 protein C-terminal region Sof1 PF04158.14 CDW55450.1 - 1.3e-30 105.5 6.8 2.4e-30 104.6 6.8 1.5 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 CDW55450.1 - 1.8e-20 72.8 8.7 0.00023 21.9 0.1 6.4 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55450.1 - 7.2e-05 23.0 0.0 0.18 12.1 0.0 3.8 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Glyco_transf_56 PF07429.11 CDW55450.1 - 0.0078 15.4 0.0 0.027 13.6 0.1 1.7 2 0 0 2 2 2 1 4-alpha-L-fucosyltransferase glycosyl transferase group 56 Reprolysin PF01421.19 CDW55451.1 - 1.5e-54 184.9 0.0 3.7e-54 183.7 0.0 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 CDW55451.1 - 8.8e-23 80.9 3.1 8.8e-23 80.9 3.1 3.3 3 0 0 3 3 3 1 ADAM cysteine-rich Reprolysin_5 PF13688.6 CDW55451.1 - 8.9e-19 68.4 0.2 8.9e-19 68.4 0.2 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12 Disintegrin PF00200.23 CDW55451.1 - 4.7e-18 65.8 28.1 4.7e-18 65.8 28.1 3.8 4 1 0 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 CDW55451.1 - 7.9e-15 55.5 0.6 1.7e-14 54.4 0.6 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CDW55451.1 - 2e-11 43.9 0.1 4.2e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CDW55451.1 - 1.6e-08 34.7 0.6 3.8e-08 33.5 0.6 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF2268 PF10026.9 CDW55451.1 - 0.014 14.9 0.1 0.025 14.2 0.1 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) Peptidase_M66 PF10462.9 CDW55451.1 - 0.031 13.2 0.2 0.05 12.6 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.24 CDW55451.1 - 0.22 11.3 0.1 0.35 10.7 0.1 1.2 1 0 0 1 1 1 0 Matrixin adh_short PF00106.25 CDW55452.1 - 1.7e-44 151.7 0.0 2.2e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW55452.1 - 2.4e-30 105.8 0.0 2.8e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW55452.1 - 8.7e-14 51.8 0.1 1.3e-13 51.3 0.1 1.1 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CDW55452.1 - 0.03 14.2 0.1 0.046 13.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDW55452.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CDW55452.1 - 0.1 11.7 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein T4SS-DNA_transf PF02534.14 CDW55452.1 - 0.14 11.0 0.1 0.8 8.4 0.0 2.0 2 1 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer DAD PF02109.16 CDW55453.1 - 6.8e-40 135.8 5.2 7.5e-40 135.6 5.2 1.0 1 0 0 1 1 1 1 DAD family DUF4229 PF14012.6 CDW55453.1 - 0.079 13.1 0.1 0.079 13.1 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Pribosyltran PF00156.27 CDW55454.1 - 2.7e-05 23.8 0.0 5.1e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CDW55454.1 - 0.12 11.8 0.0 0.83 9.1 0.0 2.0 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase DNase_II PF03265.15 CDW55455.1 - 8.6e-95 317.7 0.0 9.4e-95 317.6 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II NTPase_1 PF03266.15 CDW55456.1 - 1.2e-43 148.9 0.0 1.4e-43 148.8 0.0 1.0 1 0 0 1 1 1 1 NTPase AAA_16 PF13191.6 CDW55456.1 - 0.00021 21.7 0.2 0.0022 18.4 0.0 2.2 3 0 0 3 3 2 1 AAA ATPase domain NACHT PF05729.12 CDW55456.1 - 0.00045 20.2 0.0 0.00064 19.7 0.0 1.5 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CDW55456.1 - 0.0012 19.2 0.0 0.0044 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CDW55456.1 - 0.0043 17.5 0.0 0.019 15.4 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW55456.1 - 0.0058 16.6 0.0 0.026 14.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 CDW55456.1 - 0.0083 15.9 0.0 0.051 13.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain cobW PF02492.19 CDW55456.1 - 0.012 15.2 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CDW55456.1 - 0.013 16.0 0.3 0.018 15.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 CDW55456.1 - 0.017 14.1 0.0 0.026 13.5 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 CDW55456.1 - 0.018 15.1 0.2 0.13 12.4 0.0 2.2 2 1 1 3 3 3 0 50S ribosome-binding GTPase AAA_33 PF13671.6 CDW55456.1 - 0.034 14.3 0.0 0.071 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDW55456.1 - 0.035 14.4 0.1 0.19 12.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 CDW55456.1 - 0.035 14.0 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 RNA_helicase PF00910.22 CDW55456.1 - 0.067 13.6 0.0 0.25 11.8 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 CDW55456.1 - 0.087 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CbiA PF01656.23 CDW55456.1 - 0.097 12.7 0.0 0.3 11.2 0.0 1.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Arf PF00025.21 CDW55456.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.5 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_14 PF13173.6 CDW55456.1 - 0.13 12.3 0.0 2.5 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 CDW55456.1 - 0.14 11.8 0.0 0.4 10.3 0.0 1.7 2 0 0 2 2 1 0 SRP54-type protein, GTPase domain MobB PF03205.14 CDW55456.1 - 0.16 11.8 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 CDW55456.1 - 0.22 11.4 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Ion_trans PF00520.31 CDW55457.1 - 3.8e-05 23.0 1.0 5.4e-05 22.5 1.0 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 CDW55457.1 - 0.011 14.5 1.3 0.011 14.5 1.3 1.4 2 0 0 2 2 2 0 Polycystin cation channel DUF3742 PF12553.8 CDW55457.1 - 0.016 15.3 0.1 0.025 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) HA2 PF04408.23 CDW55458.1 - 8.2e-21 74.3 0.0 8.2e-21 74.3 0.0 3.0 3 1 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDW55458.1 - 3.7e-20 72.1 0.0 8.5e-20 70.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDW55458.1 - 6.8e-13 48.9 0.1 3.2e-12 46.8 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW55458.1 - 1.7e-08 34.4 0.2 4.9e-08 32.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_30 PF13604.6 CDW55458.1 - 0.00015 21.5 0.0 0.00055 19.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW55458.1 - 0.00035 20.9 0.0 0.00035 20.9 0.0 2.5 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDW55458.1 - 0.00043 19.4 0.0 0.0013 17.9 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 CDW55458.1 - 0.00048 20.5 1.1 0.0012 19.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 CDW55458.1 - 0.0013 18.0 3.1 0.0023 17.3 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 CDW55458.1 - 0.0038 17.2 0.2 0.012 15.5 0.1 1.9 3 0 0 3 3 3 1 Flavivirus DEAD domain PWI PF01480.17 CDW55458.1 - 0.0075 16.6 0.0 0.037 14.4 0.0 2.3 1 0 0 1 1 1 1 PWI domain Reprolysin PF01421.19 CDW55458.1 - 0.16 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease SRP54 PF00448.22 CDW55458.1 - 0.18 11.4 0.8 1 9.0 0.1 2.5 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain ATPase PF06745.13 CDW55458.1 - 0.22 10.9 0.0 0.22 10.9 0.0 1.9 2 0 0 2 2 2 0 KaiC MutL_C PF08676.11 CDW55459.1 - 7e-17 61.6 0.2 9.2e-15 54.7 0.0 2.5 1 1 1 2 2 2 2 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CDW55459.1 - 6.9e-10 38.6 0.1 2.9e-08 33.4 0.1 2.6 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CDW55459.1 - 3.3e-08 33.5 0.0 7e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDW55459.1 - 2.9e-05 24.5 0.0 7.6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FAD_binding_6 PF00970.24 CDW55460.1 - 1.1e-34 118.7 0.0 1.8e-34 118.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CDW55460.1 - 2.5e-32 111.8 0.0 4e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CDW55460.1 - 2.2e-06 27.9 0.0 0.00013 22.1 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain LPD25 PF18840.1 CDW55460.1 - 0.13 12.8 0.0 0.44 11.1 0.0 1.8 2 0 0 2 2 2 0 Large polyvalent protein associated domain 25 TraT PF05818.12 CDW55461.1 - 0.94 9.1 3.7 1.2 8.8 3.7 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Tristanin_u2 PF16638.5 CDW55461.1 - 8.8 7.2 5.8 13 6.7 5.8 1.2 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers Ank_2 PF12796.7 CDW55462.1 - 0.0038 17.8 0.0 0.011 16.3 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) fn3 PF00041.21 CDW55462.1 - 0.11 12.9 0.0 0.3 11.5 0.0 1.8 2 0 0 2 2 2 0 Fibronectin type III domain Glyco_transf_20 PF00982.21 CDW55463.1 - 1.1e-72 245.2 0.0 2.3e-72 244.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 20 T6PP_N PF18572.1 CDW55463.1 - 9e-13 47.9 0.9 2e-12 46.8 0.2 2.0 2 0 0 2 2 2 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Ndufs5 PF10200.9 CDW55463.1 - 2.1e-09 37.5 0.1 5.6e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DnaJ PF00226.31 CDW55464.1 - 3.6e-15 55.8 0.6 5.4e-15 55.3 0.6 1.3 1 0 0 1 1 1 1 DnaJ domain Yippee-Mis18 PF03226.14 CDW55466.1 - 1.9e-08 34.5 3.2 4.8e-07 29.9 1.4 2.1 2 0 0 2 2 2 2 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Jas PF16135.5 CDW55466.1 - 0.038 14.2 0.5 0.038 14.2 0.5 2.0 2 1 1 3 3 3 0 TPL-binding domain in jasmonate signalling cwf21 PF08312.12 CDW55467.1 - 6.4e-15 55.0 7.2 1.1e-14 54.3 7.2 1.4 1 0 0 1 1 1 1 cwf21 domain Ribosomal_L50 PF10501.9 CDW55468.1 - 1.8e-11 44.1 0.2 3.5e-11 43.2 0.2 1.5 2 0 0 2 2 2 1 Ribosomal subunit 39S HECT_2 PF09814.9 CDW55469.1 - 1.2e-09 37.5 0.0 1.6e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zinc_ribbon_4 PF13717.6 CDW55469.1 - 0.49 10.3 2.2 6.4 6.8 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Peptidase_M8 PF01457.16 CDW55470.1 - 1.3e-65 222.1 8.3 8.6e-50 169.9 5.2 2.4 2 0 0 2 2 2 2 Leishmanolysin Patched PF02460.18 CDW55471.1 - 2.1e-125 419.7 23.4 2.6e-125 419.4 23.4 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW55471.1 - 4.2e-42 143.6 3.9 4.2e-42 143.6 3.9 4.2 5 1 1 6 6 6 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 CDW55471.1 - 0.0023 16.9 0.2 0.0023 16.9 0.2 3.0 3 1 0 3 3 3 1 MMPL family ACR_tran PF00873.19 CDW55471.1 - 0.092 10.4 11.0 0.17 9.5 11.0 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Pkinase PF00069.25 CDW55472.1 - 1.5e-08 34.3 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55472.1 - 0.00014 21.3 0.0 0.00019 20.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW55472.1 - 0.0042 16.4 0.0 0.0067 15.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Surp PF01805.20 CDW55473.1 - 1.3e-27 95.5 3.0 2.4e-13 49.8 0.4 2.6 2 0 0 2 2 2 2 Surp module DRY_EERY PF09750.9 CDW55473.1 - 3.8e-20 72.5 0.2 3.8e-20 72.5 0.2 3.6 4 1 0 4 4 4 1 Alternative splicing regulator BSP_II PF05432.11 CDW55473.1 - 0.0073 16.0 5.7 0.0073 16.0 5.7 3.3 4 0 0 4 4 4 1 Bone sialoprotein II (BSP-II) CENP-B_dimeris PF09026.10 CDW55473.1 - 0.53 10.7 5.5 3.6 8.0 2.4 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PI3K_1B_p101 PF10486.9 CDW55473.1 - 0.76 7.5 21.1 1.4 6.6 21.1 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RNase_T PF00929.24 CDW55474.1 - 2.9e-21 76.7 0.0 4e-21 76.3 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Ost4 PF10215.9 CDW55475.1 - 2.2e-13 49.8 1.3 2.4e-13 49.6 1.3 1.0 1 0 0 1 1 1 1 Oligosaccaryltransferase Kinesin PF00225.23 CDW55476.1 - 1e-112 376.4 1.5 1.9e-112 375.5 1.5 1.5 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 CDW55476.1 - 9.6e-47 159.4 13.8 4.9e-36 124.5 3.4 4.4 2 1 1 3 3 3 2 Kinesin-associated DUF3694 PF12473.8 CDW55476.1 - 1.7e-32 113.2 0.0 5.8e-32 111.5 0.0 2.0 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.5 CDW55476.1 - 7.3e-21 74.7 0.3 7.3e-21 74.7 0.3 2.7 3 0 0 3 3 3 1 Microtubule binding PH PF00169.29 CDW55476.1 - 7.6e-12 45.7 0.0 4.5e-11 43.2 0.0 2.5 1 0 0 1 1 1 1 PH domain KIF1B PF12423.8 CDW55476.1 - 2e-09 37.8 2.0 1.3e-08 35.2 0.0 2.8 2 0 0 2 2 2 1 Kinesin protein 1B FHA PF00498.26 CDW55476.1 - 6e-07 29.7 0.0 2.5e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 FHA domain PH_11 PF15413.6 CDW55476.1 - 0.00041 20.7 0.3 0.0096 16.3 0.3 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 CDW55476.1 - 0.0054 17.1 0.1 0.04 14.3 0.1 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Yop-YscD_cpl PF16697.5 CDW55476.1 - 0.029 14.7 0.0 0.08 13.3 0.0 1.7 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain HemX PF04375.14 CDW55476.1 - 0.14 11.4 4.8 0.41 9.9 0.1 2.4 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4482 PF14818.6 CDW55476.1 - 0.62 10.9 12.1 0.1 13.5 6.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) RasGAP PF00616.19 CDW55477.1 - 3.4e-26 92.2 0.7 6.1e-17 62.0 0.2 2.4 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 CDW55477.1 - 3.8e-09 36.8 0.0 3.3e-08 33.7 0.0 2.4 2 0 0 2 2 2 1 C2 domain CP2 PF04516.15 CDW55479.1 - 3.1e-58 196.8 1.0 6e-58 195.9 1.0 1.4 1 0 0 1 1 1 1 CP2 transcription factor SNF PF00209.18 CDW55481.1 - 1.8e-189 630.8 27.0 2.1e-189 630.6 27.0 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Tetraspanin PF00335.20 CDW55483.1 - 8.8e-53 179.4 8.1 1.1e-52 179.1 8.1 1.0 1 0 0 1 1 1 1 Tetraspanin family CD47 PF04549.14 CDW55483.1 - 0.4 10.9 11.7 0.58 10.3 11.7 1.3 1 0 0 1 1 1 0 CD47 transmembrane region DUF2650 PF10853.8 CDW55483.1 - 1 9.1 13.6 3.6 7.4 0.4 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2650) HSP20 PF00011.21 CDW55484.1 - 4.1e-14 52.6 0.0 4.8e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW55484.1 - 7.5e-06 25.4 0.0 1.1e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HD_3 PF13023.6 CDW55485.1 - 1.7e-41 141.9 0.2 2.1e-41 141.6 0.2 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 CDW55485.1 - 1.2e-14 54.4 0.2 1.8e-14 53.9 0.2 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 CDW55485.1 - 0.0009 19.5 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 HD domain Nbas_N PF15492.6 CDW55485.1 - 0.0045 16.4 0.0 0.0063 15.9 0.0 1.2 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal PPK2 PF03976.14 CDW55485.1 - 0.065 12.7 0.1 0.091 12.2 0.1 1.2 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) DHHC PF01529.20 CDW55486.1 - 2.5e-36 124.7 17.3 2.5e-36 124.7 17.3 2.2 2 1 0 2 2 2 1 DHHC palmitoyltransferase DUF3989 PF13150.6 CDW55486.1 - 1.6 8.5 4.2 0.47 10.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) TPR_11 PF13414.6 CDW55487.1 - 7.3e-05 22.4 0.4 0.02 14.5 0.1 3.5 3 1 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 CDW55487.1 - 0.00052 20.2 1.7 0.49 10.9 0.0 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDW55487.1 - 0.026 15.3 0.3 1.4 10.0 0.0 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 CDW55487.1 - 0.056 12.7 0.1 0.16 11.2 0.1 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55487.1 - 0.17 12.2 1.2 0.97 9.8 0.0 2.9 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_8 PF13855.6 CDW55489.1 - 7.7e-70 230.6 69.9 3.2e-15 55.6 2.9 13.5 7 4 5 14 14 14 12 Leucine rich repeat LRR_4 PF12799.7 CDW55489.1 - 2.3e-49 164.5 57.8 7.1e-05 23.1 3.4 14.7 12 2 2 14 14 14 12 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW55489.1 - 2.2e-25 89.1 0.0 4.5e-06 26.6 0.0 5.3 4 1 0 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 CDW55489.1 - 6.4e-18 64.9 19.3 3.4e-05 23.4 1.3 7.8 2 2 6 8 8 8 6 Leucine-rich repeat TIR_2 PF13676.6 CDW55489.1 - 5e-11 43.3 0.6 1.8e-10 41.4 0.4 2.0 2 0 0 2 2 2 1 TIR domain TIR PF01582.20 CDW55489.1 - 6.5e-11 42.3 0.0 1.1e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.33 CDW55489.1 - 0.00031 20.9 72.2 0.69 10.7 0.5 18.6 22 1 0 22 22 22 3 Leucine Rich Repeat LRR_6 PF13516.6 CDW55489.1 - 0.1 12.7 61.8 0.45 10.7 0.6 15.2 20 0 0 20 20 20 0 Leucine Rich repeat PDZ PF00595.24 CDW55490.1 - 1.3e-14 54.3 0.1 2.4e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW55490.1 - 0.00043 20.1 0.0 0.00088 19.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DUF3540 PF12059.8 CDW55490.1 - 0.14 12.0 1.2 0.26 11.1 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) PDZ_2 PF13180.6 CDW55490.1 - 0.17 12.2 0.0 0.44 10.9 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Pkinase PF00069.25 CDW55491.1 - 1.2e-60 205.2 0.1 1.6e-59 201.4 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55491.1 - 4.3e-27 95.0 0.0 5.2e-20 71.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 CDW55491.1 - 0.00021 21.3 0.3 0.051 13.5 0.7 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDW55491.1 - 0.00023 20.2 0.1 0.00039 19.5 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW55491.1 - 0.00081 18.8 0.3 0.0044 16.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 CDW55491.1 - 0.008 15.0 0.0 0.016 14.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDW55491.1 - 0.014 14.8 0.2 0.026 13.9 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 CDW55491.1 - 0.034 13.2 0.0 0.058 12.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_C PF00433.24 CDW55491.1 - 0.042 14.5 0.2 0.13 12.9 0.2 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain RIO1 PF01163.22 CDW55491.1 - 0.13 11.9 0.7 1 9.0 0.0 2.3 2 0 0 2 2 2 0 RIO1 family McyA_C PF12593.8 CDW55491.1 - 1.3 8.9 3.4 1.8 8.4 1.1 2.2 2 0 0 2 2 2 0 Microcystin synthetase C terminal Chromo PF00385.24 CDW55492.1 - 4e-18 65.1 0.5 1e-17 63.7 0.5 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 CDW55492.1 - 1.2e-08 34.9 0.5 2.3e-06 27.6 0.1 2.4 2 0 0 2 2 2 2 Chromo shadow domain Mtf2_C PF14061.6 CDW55492.1 - 0.0059 16.7 0.1 0.096 12.9 0.0 2.4 2 0 0 2 2 2 1 Polycomb-like MTF2 factor 2 Ribosomal_L16 PF00252.18 CDW55493.1 - 3.5e-21 75.6 0.0 4.4e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Histone PF00125.24 CDW55494.1 - 1.9e-18 67.0 0.2 2.4e-18 66.7 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW55494.1 - 0.00011 22.5 0.2 0.00027 21.2 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Nup88 PF10168.9 CDW55494.1 - 0.052 11.4 0.1 0.063 11.1 0.1 1.0 1 0 0 1 1 1 0 Nuclear pore component TFIID_20kDa PF03847.13 CDW55494.1 - 0.062 13.8 0.0 0.097 13.2 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Oxidored_q6 PF01058.22 CDW55495.1 - 2.1e-16 59.9 0.0 3.9e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Ribosomal_S21 PF01165.20 CDW55496.1 - 2.8e-13 49.4 0.2 6.7e-13 48.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S21 SNase PF00565.17 CDW55496.1 - 0.018 15.5 0.2 0.12 12.8 0.0 2.5 2 1 0 2 2 2 0 Staphylococcal nuclease homologue Prenyltrans PF00432.21 CDW55497.1 - 9e-26 89.3 6.1 8.7e-09 35.0 0.1 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat BAF250_C PF12031.8 CDW55498.1 - 7e-69 232.0 2.1 1e-68 231.4 2.1 1.2 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa ARID PF01388.21 CDW55498.1 - 1.3e-08 35.4 0.0 3.3e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain SUIM_assoc PF16619.5 CDW55498.1 - 0.32 11.1 17.0 0.17 12.0 0.4 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 FAM176 PF14851.6 CDW55499.1 - 0.035 13.7 0.4 0.066 12.9 0.1 1.6 2 0 0 2 2 2 0 FAM176 family Glyco_transf_10 PF00852.19 CDW55501.1 - 5.3e-53 179.4 4.3 6.9e-53 179.0 4.3 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW55501.1 - 7.8e-26 90.7 0.0 1.6e-25 89.7 0.0 1.6 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Innexin PF00876.18 CDW55502.1 - 1e-123 413.1 14.5 6.5e-109 364.4 13.8 2.1 2 0 0 2 2 2 2 Innexin PDEase_I PF00233.19 CDW55503.1 - 3e-87 292.3 0.3 5.8e-87 291.4 0.0 1.6 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDE4_UCR PF18100.1 CDW55503.1 - 4.3e-41 140.3 0.7 3.8e-40 137.2 0.4 2.6 2 0 0 2 2 2 1 Phosphodiesterase 4 upstream conserved regions (UCR) CAF1A PF12253.8 CDW55504.1 - 0.017 15.3 0.3 0.12 12.5 0.3 2.1 1 1 0 1 1 1 0 Chromatin assembly factor 1 subunit A zf-C2H2 PF00096.26 CDW55507.1 - 2.3e-07 30.9 22.4 0.011 16.2 1.1 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW55507.1 - 5e-06 26.9 24.1 0.027 15.3 0.6 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 CDW55507.1 - 1e-05 25.7 19.3 0.0055 17.1 1.0 4.1 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW55507.1 - 0.0028 17.9 9.6 0.023 15.0 0.3 3.4 1 1 1 2 2 2 1 Zinc-finger double-stranded RNA-binding Jnk-SapK_ap_N PF09744.9 CDW55507.1 - 0.0045 17.2 0.5 0.0045 17.2 0.5 1.9 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 bZIP_1 PF00170.21 CDW55507.1 - 0.014 15.4 0.7 0.014 15.4 0.7 2.0 2 0 0 2 2 1 0 bZIP transcription factor Yippee-Mis18 PF03226.14 CDW55507.1 - 0.03 14.5 5.4 0.097 12.9 5.4 2.0 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly HIPIP PF01355.17 CDW55507.1 - 0.089 13.2 0.3 0.089 13.2 0.3 2.2 2 0 0 2 2 1 0 High potential iron-sulfur protein zf-C2H2_2 PF12756.7 CDW55507.1 - 0.19 12.1 15.8 0.59 10.5 2.7 3.6 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 CDW55507.1 - 0.28 11.5 13.8 0.064 13.6 5.0 2.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 CDW55507.1 - 0.41 10.7 7.5 1.1 9.3 0.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW55507.1 - 3.7 8.2 11.7 7.5 7.2 0.5 3.7 3 0 0 3 3 3 0 Zinc-finger double domain DUF3984 PF13136.6 CDW55509.1 - 0.0094 15.4 0.5 0.011 15.2 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) WW PF00397.26 CDW55509.1 - 0.041 14.0 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 WW domain WW PF00397.26 CDW55510.1 - 1.8e-09 37.5 9.3 1.2e-08 34.9 2.2 2.4 2 0 0 2 2 2 2 WW domain TMEM119 PF15724.5 CDW55510.1 - 0.067 13.3 0.5 0.089 12.8 0.5 1.1 1 0 0 1 1 1 0 TMEM119 family STAG PF08514.11 CDW55511.1 - 2.2e-36 124.2 2.5 1e-35 122.1 2.5 2.2 1 0 0 1 1 1 1 STAG domain DUF2235 PF09994.9 CDW55511.1 - 0.14 11.5 0.1 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF2968 PF11180.8 CDW55511.1 - 0.15 11.7 6.5 0.27 10.8 6.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Ig_3 PF13927.6 CDW55512.1 - 0.00011 22.7 0.0 0.2 12.3 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 CDW55512.1 - 0.0033 17.5 0.5 1.2 9.4 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 CDW55512.1 - 0.033 14.4 0.3 5.3 7.3 0.0 3.2 2 2 0 2 2 2 0 Immunoglobulin V-set domain Ig_6 PF18452.1 CDW55512.1 - 0.066 12.8 0.3 12 5.6 0.0 2.5 2 0 0 2 2 2 0 Immunoglobulin domain Stc1 PF12898.7 CDW55512.1 - 0.17 12.5 0.4 0.51 10.9 0.1 1.9 2 0 0 2 2 2 0 Stc1 domain TSP_1 PF00090.19 CDW55512.1 - 2 8.7 4.5 1.2 9.5 1.8 2.0 2 0 0 2 2 2 0 Thrombospondin type 1 domain LIM PF00412.22 CDW55513.1 - 6.5e-26 90.3 23.3 5.9e-13 48.8 4.6 2.1 2 0 0 2 2 2 2 LIM domain DZR PF12773.7 CDW55513.1 - 0.051 13.6 19.1 47 4.1 19.1 3.4 1 1 0 1 1 1 0 Double zinc ribbon zf-rbx1 PF12678.7 CDW55513.1 - 0.17 12.2 12.9 0.31 11.3 0.5 3.2 2 1 1 3 3 3 0 RING-H2 zinc finger domain PHF5 PF03660.14 CDW55513.1 - 1.8 8.8 10.9 3.4 7.9 8.5 2.2 1 1 1 2 2 2 0 PHF5-like protein zf-FLZ PF04570.14 CDW55513.1 - 6.1 6.4 21.5 0.61 9.6 2.9 3.4 3 1 1 4 4 4 0 zinc-finger of the FCS-type, C2-C2 LRR_8 PF13855.6 CDW55514.1 - 2.6e-44 148.8 17.4 2.6e-15 55.9 1.6 4.3 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 CDW55514.1 - 5.6e-26 90.2 7.6 3.5e-06 27.3 0.1 5.3 3 1 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW55514.1 - 1e-16 61.1 0.0 1.5e-07 31.4 0.0 2.2 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CDW55514.1 - 1.2e-16 58.7 0.3 1.9 9.3 0.1 8.5 8 0 0 8 8 8 4 Leucine Rich Repeat LRR_9 PF14580.6 CDW55514.1 - 9.6e-11 41.5 0.0 1.7e-06 27.7 0.0 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 CDW55514.1 - 2.3e-07 30.3 16.3 6.4 7.1 0.0 8.1 8 0 0 8 8 8 3 Leucine Rich repeat LRRNT PF01462.18 CDW55514.1 - 2.6e-05 23.7 2.7 6.7e-05 22.4 2.7 1.6 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain UCH PF00443.29 CDW55516.1 - 0.00024 20.7 0.1 0.0014 18.2 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DEAD PF00270.29 CDW55517.1 - 2.6e-46 157.6 0.0 4.8e-46 156.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW55517.1 - 6.6e-26 90.8 0.1 1.6e-24 86.4 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDW55517.1 - 9.2e-19 67.4 0.3 1.9e-18 66.4 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CDW55517.1 - 2.3e-05 24.5 0.0 4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 CDW55517.1 - 0.12 11.6 0.0 0.4 9.9 0.0 1.8 1 1 0 1 1 1 0 SecA DEAD-like domain zf-RING_2 PF13639.6 CDW55518.1 - 9.3e-14 51.5 7.1 9.3e-14 51.5 7.1 2.4 3 0 0 3 3 2 1 Ring finger domain zf-RING_11 PF17123.5 CDW55518.1 - 3.8e-10 39.3 3.8 3.8e-10 39.3 3.8 2.6 3 0 0 3 3 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDW55518.1 - 2.3e-08 33.7 4.9 2.3e-08 33.7 4.9 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDW55518.1 - 8e-08 32.5 6.4 8e-08 32.5 6.4 2.9 2 2 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CDW55518.1 - 4.2e-07 29.8 4.3 4.2e-07 29.8 4.3 2.0 3 0 0 3 3 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDW55518.1 - 1e-05 25.3 4.9 1e-05 25.3 4.9 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDW55518.1 - 1.4e-05 24.8 4.6 1.4e-05 24.8 4.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDW55518.1 - 0.0011 18.6 3.9 0.0034 17.0 3.9 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDW55518.1 - 0.01 15.8 4.4 0.01 15.8 4.4 2.8 2 2 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 CDW55518.1 - 0.14 12.4 4.6 0.37 11.0 4.6 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 CDW55518.1 - 0.17 12.1 6.2 0.56 10.4 6.2 2.0 1 0 0 1 1 1 0 RING-variant domain Asn_synthase PF00733.21 CDW55519.1 - 7e-11 42.4 1.1 2.4e-06 27.4 0.7 3.0 1 1 1 2 2 2 2 Asparagine synthase Peptidase_M9_N PF08453.10 CDW55519.1 - 0.23 11.2 0.0 0.38 10.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M9 N-terminal EF-hand_4 PF12763.7 CDW55520.1 - 4.4e-23 81.2 0.0 1.7e-19 69.6 0.0 3.4 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 CDW55520.1 - 1.4e-11 43.0 3.5 0.0022 17.4 0.1 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 CDW55520.1 - 1.4e-09 37.1 3.8 0.013 15.3 0.2 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 CDW55520.1 - 4.3e-08 33.5 1.0 0.13 12.7 0.0 3.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 CDW55520.1 - 0.00029 20.6 2.1 2.1 8.3 0.2 3.4 3 0 0 3 3 3 2 EF-hand domain pair Excalibur PF05901.11 CDW55520.1 - 0.032 14.9 0.3 0.074 13.7 0.0 1.8 2 0 0 2 2 2 0 Excalibur calcium-binding domain EF-hand_5 PF13202.6 CDW55520.1 - 0.49 10.0 12.5 0.77 9.4 0.7 3.1 4 0 0 4 4 4 0 EF hand PIGA PF08288.12 CDW55521.1 - 1.9e-31 108.5 1.9 5.5e-31 107.0 1.9 1.9 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 CDW55521.1 - 1.9e-29 102.9 0.2 2.7e-29 102.3 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDW55521.1 - 9.2e-12 45.7 0.0 1.7e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 CDW55521.1 - 2.3e-10 41.0 0.0 5.9e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CDW55521.1 - 9.9e-09 35.0 0.0 3.9e-08 33.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 CDW55521.1 - 0.0083 15.8 0.0 0.28 10.8 0.0 2.2 2 0 0 2 2 2 1 Starch synthase catalytic domain 4HBT_3 PF13622.6 CDW55522.1 - 4.5e-31 109.0 0.0 5.6e-31 108.7 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CDW55522.1 - 6.5e-24 84.3 0.6 2.1e-21 76.1 0.2 2.9 2 1 0 2 2 2 2 Acyl-CoA thioesterase KH_1 PF00013.29 CDW55523.1 - 1.8e-11 43.7 0.2 2.9e-11 43.0 0.2 1.3 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 CDW55523.1 - 0.0068 16.2 0.7 0.015 15.1 0.6 1.6 1 1 0 1 1 1 1 KH domain Myb_DNA-binding PF00249.31 CDW55524.1 - 0.0037 17.4 0.0 0.0081 16.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CDW55524.1 - 0.028 14.3 0.1 0.067 13.1 0.1 1.6 1 0 0 1 1 1 0 Myb DNA-binding like ELM2 PF01448.24 CDW55524.1 - 0.14 12.9 2.3 0.48 11.2 0.1 3.0 3 1 0 3 3 3 0 ELM2 domain CHORD PF04968.12 CDW55525.1 - 6.3e-25 87.7 17.0 1.6e-22 80.0 5.7 3.3 3 0 0 3 3 3 2 CHORD CS PF04969.16 CDW55525.1 - 7.9e-12 46.0 0.3 2.2e-11 44.6 0.1 1.8 2 0 0 2 2 2 1 CS domain TBCC PF07986.12 CDW55526.1 - 4.2e-30 103.9 7.0 6.5e-30 103.3 7.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 CDW55526.1 - 5.4e-09 36.5 2.9 1.1e-08 35.5 2.9 1.4 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain CAP_C PF08603.11 CDW55526.1 - 0.061 12.9 3.1 0.098 12.3 3.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal DASH_Spc19 PF08287.11 CDW55526.1 - 0.33 10.9 5.2 1.7 8.5 0.9 2.7 1 1 1 2 2 2 0 Spc19 SMC_N PF02463.19 CDW55528.1 - 2.5e-07 30.4 0.0 2.5e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDW55528.1 - 0.00073 19.8 0.0 0.0013 19.1 0.0 1.4 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain Choline_kinase PF01633.20 CDW55529.1 - 1e-63 214.8 0.1 1.3e-63 214.4 0.1 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 CDW55529.1 - 3.6e-14 53.3 0.0 4.8e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDW55529.1 - 1.1e-08 34.8 0.6 1.7e-08 34.1 0.6 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 CDW55529.1 - 0.0005 19.0 0.1 0.00073 18.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Malectin PF11721.8 CDW55530.1 - 8e-41 139.9 0.2 1e-40 139.5 0.2 1.1 1 0 0 1 1 1 1 Malectin domain Malectin_like PF12819.7 CDW55530.1 - 0.015 14.5 0.0 0.043 13.0 0.0 1.7 1 1 0 1 1 1 0 Malectin-like domain CBM_35 PF16990.5 CDW55530.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding module (family 35) SNF2_N PF00176.23 CDW55531.1 - 1.4e-36 125.9 0.6 2.4e-36 125.2 0.6 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW55531.1 - 1.4e-17 64.0 0.1 6.1e-17 62.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDW55531.1 - 5.8e-06 25.7 0.1 1e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 CDW55531.1 - 0.00033 19.9 1.9 0.014 14.6 0.4 2.5 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 CDW55531.1 - 0.037 14.0 0.0 0.091 12.8 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit NHL PF01436.21 CDW55532.1 - 6.4e-22 76.4 12.6 6.1e-09 35.5 0.3 6.2 6 0 0 6 6 6 3 NHL repeat zf-RING_UBOX PF13445.6 CDW55532.1 - 0.00017 21.5 0.7 0.00017 21.5 0.7 3.6 3 1 1 4 4 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDW55532.1 - 0.00027 20.7 0.8 0.00027 20.7 0.8 4.3 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 CDW55532.1 - 0.0006 19.9 8.7 0.0006 19.9 8.7 4.1 4 0 0 4 4 4 2 B-box zinc finger zf-C3HC4 PF00097.25 CDW55532.1 - 0.00083 19.2 7.1 0.00083 19.2 7.1 4.2 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW55532.1 - 0.0039 17.1 3.7 0.0039 17.1 3.7 4.1 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDW55532.1 - 0.0069 16.5 1.2 0.0069 16.5 1.2 4.4 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING DUF5128 PF17170.4 CDW55532.1 - 0.0074 15.5 0.1 2.4 7.2 0.0 2.5 2 1 0 2 2 2 2 6-bladed beta-propeller Apolipoprotein PF01442.18 CDW55532.1 - 0.0081 16.1 0.4 0.012 15.5 0.4 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain SF-assemblin PF06705.11 CDW55532.1 - 0.053 12.9 3.1 0.078 12.3 3.1 1.1 1 0 0 1 1 1 0 SF-assemblin/beta giardin RRF PF01765.19 CDW55532.1 - 0.1 12.5 0.6 0.17 11.8 0.6 1.3 1 0 0 1 1 1 0 Ribosome recycling factor Nore1-SARAH PF16517.5 CDW55532.1 - 0.14 12.1 0.8 0.25 11.3 0.8 1.4 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Haspin_kinase PF12330.8 CDW55533.1 - 2.2e-07 30.2 0.0 2.2e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDW55533.1 - 0.036 14.0 0.0 0.049 13.5 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDW55533.1 - 0.073 12.6 0.0 0.077 12.6 0.0 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase Homeodomain PF00046.29 CDW55534.1 - 1.7e-22 79.0 3.9 3e-22 78.2 3.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW55534.1 - 0.068 13.1 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 CDW55534.1 - 0.098 12.1 0.2 0.19 11.2 0.2 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez FERM_N PF09379.10 CDW55535.1 - 1.2e-14 54.0 0.2 2.1e-14 53.2 0.2 1.3 1 0 0 1 1 1 1 FERM N-terminal domain Cse1 PF08506.10 CDW55536.1 - 1.4e-105 353.1 0.4 1.4e-105 353.1 0.4 2.0 3 0 0 3 3 3 1 Cse1 CAS_CSE1 PF03378.15 CDW55536.1 - 1e-84 284.6 2.5 1.7e-84 283.9 2.5 1.4 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 CDW55536.1 - 2e-10 40.4 0.1 8.2e-10 38.5 0.1 2.2 1 0 0 1 1 1 1 Importin-beta N-terminal domain TAF6_C PF07571.13 CDW55536.1 - 0.049 13.9 0.5 15 6.0 0.1 4.1 4 0 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain HEAT PF02985.22 CDW55536.1 - 0.063 13.6 0.6 0.76 10.2 0.1 3.3 2 0 0 2 2 2 0 HEAT repeat Arm PF00514.23 CDW55536.1 - 0.066 13.3 1.9 8.9 6.5 0.3 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Xpo1 PF08389.12 CDW55536.1 - 0.084 12.9 0.7 0.58 10.2 0.1 2.9 2 1 0 2 2 2 0 Exportin 1-like protein Telomere_reg-2 PF10193.9 CDW55536.1 - 1.1 9.7 4.8 10 6.6 0.0 3.8 3 1 1 4 4 4 0 Telomere length regulation protein WD40 PF00400.32 CDW55538.1 - 4.5e-18 65.3 11.3 0.00033 21.4 0.5 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55538.1 - 2.9e-10 40.3 0.1 0.00084 19.6 0.0 4.9 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW55538.1 - 7.6e-05 21.8 1.0 3.5 6.5 0.0 3.6 2 2 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDW55538.1 - 0.0003 20.2 0.0 0.013 14.8 0.0 2.3 1 1 1 2 2 2 1 WD40-like domain GXGXG PF01493.19 CDW55538.1 - 0.0032 17.1 0.0 0.0055 16.3 0.0 1.4 1 0 0 1 1 1 1 GXGXG motif PQQ_3 PF13570.6 CDW55538.1 - 0.0048 17.3 1.1 0.17 12.4 0.1 3.2 3 0 0 3 3 3 1 PQQ-like domain Nup160 PF11715.8 CDW55538.1 - 0.019 13.7 1.3 0.15 10.7 0.5 2.4 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CDW55538.1 - 0.019 13.5 1.6 2 6.9 0.1 2.4 1 1 0 2 2 2 0 Cytochrome D1 heme domain Glycos_transf_1 PF00534.20 CDW55539.1 - 8.6e-39 132.8 0.0 1.9e-38 131.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 adh_short PF00106.25 CDW55539.1 - 2.5e-34 118.5 0.0 4.5e-34 117.6 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW55539.1 - 1.5e-29 103.2 0.0 2.5e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glyco_trans_1_4 PF13692.6 CDW55539.1 - 4.2e-19 69.3 0.0 1.3e-18 67.7 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDW55539.1 - 2.1e-12 47.3 0.0 3.8e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDW55539.1 - 7.2e-07 29.5 0.0 1.6e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CDW55539.1 - 8.6e-06 26.3 0.0 1.6e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain KR PF08659.10 CDW55539.1 - 0.0062 16.5 0.0 0.015 15.2 0.0 1.6 1 0 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.21 CDW55539.1 - 0.017 15.2 0.1 0.061 13.4 0.1 1.9 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain THF_DHG_CYH_C PF02882.19 CDW55539.1 - 0.045 13.1 0.0 0.096 12.0 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ALG11_N PF15924.5 CDW55539.1 - 0.33 11.0 3.1 5.9 6.9 0.6 3.4 3 1 1 4 4 4 0 ALG11 mannosyltransferase N-terminus KH_1 PF00013.29 CDW55540.1 - 0.00015 21.5 0.7 0.0013 18.5 0.7 2.4 1 1 0 1 1 1 1 KH domain KH_2 PF07650.17 CDW55540.1 - 0.051 13.4 0.1 0.85 9.5 0.1 2.3 2 0 0 2 2 2 0 KH domain FAR1 PF03101.15 CDW55540.1 - 0.42 11.4 2.6 0.34 11.6 0.5 1.9 2 0 0 2 2 2 0 FAR1 DNA-binding domain SPAM PF02090.15 CDW55541.1 - 0.12 12.2 0.1 0.16 11.8 0.1 1.2 1 0 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein DEP PF00610.21 CDW55542.1 - 1.7e-10 40.8 0.0 6.6e-10 38.9 0.0 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF148 PF02520.17 CDW55542.1 - 0.06 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF148 RhoGAP PF00620.27 CDW55542.1 - 0.1 12.5 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 RhoGAP domain Asp5 PF17000.5 CDW55543.1 - 0.15 12.2 5.7 0.29 11.3 0.5 2.3 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 DUF21 PF01595.20 CDW55543.1 - 7.3 6.3 10.6 10 5.8 10.2 1.5 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain DUF1496 PF07383.12 CDW55544.1 - 0.013 15.1 0.6 0.1 12.2 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1496) EF-hand_7 PF13499.6 CDW55545.1 - 9.2e-22 77.3 8.7 3.5e-14 53.0 0.3 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW55545.1 - 1.1e-21 74.7 10.7 3.6e-07 29.3 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CDW55545.1 - 7.8e-20 69.1 8.7 5.6e-06 25.9 0.2 4.7 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDW55545.1 - 8.7e-15 54.3 5.3 2e-08 33.9 0.5 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 CDW55545.1 - 9.4e-11 40.7 6.0 9.2e-05 21.8 0.3 3.7 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 CDW55545.1 - 7.3e-08 32.3 3.1 0.027 14.4 0.0 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CDW55545.1 - 0.0015 18.8 1.7 1.9 8.8 0.4 3.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CDW55545.1 - 0.0015 18.8 0.0 0.018 15.4 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain Homeobox_KN PF05920.11 CDW55545.1 - 0.13 12.2 0.5 0.27 11.2 0.5 1.4 1 0 0 1 1 1 0 Homeobox KN domain Caleosin PF05042.13 CDW55545.1 - 1 9.2 4.9 43 4.0 0.0 3.5 3 1 1 4 4 4 0 Caleosin related protein Costars PF14705.6 CDW55546.1 - 1.9e-22 79.2 0.0 3e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Costars DOG1 PF14144.6 CDW55546.1 - 0.095 12.9 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Seed dormancy control Peptidase_M48_N PF16491.5 CDW55548.1 - 1.5e-51 174.9 6.0 1.5e-51 174.9 6.0 2.0 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CDW55548.1 - 5.6e-45 153.5 0.1 1.3e-44 152.3 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M48 Zw10 PF06248.13 CDW55549.1 - 2e-08 33.3 0.3 5.4e-08 31.9 0.3 1.7 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 PPP4R2 PF09184.11 CDW55550.1 - 0.0059 16.2 7.7 0.0064 16.1 7.7 1.1 1 0 0 1 1 1 1 PPP4R2 DUF2722 PF10846.8 CDW55550.1 - 0.051 12.5 8.3 0.056 12.4 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 CDW55550.1 - 0.71 8.6 6.1 0.76 8.5 6.1 1.0 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 CDW55550.1 - 0.94 8.7 13.3 1.1 8.5 13.3 1.1 1 0 0 1 1 1 0 NOA36 protein TFB6 PF17110.5 CDW55550.1 - 1.2 8.8 6.3 1.5 8.5 6.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RR_TM4-6 PF06459.12 CDW55550.1 - 1.3 8.8 9.4 1.6 8.5 9.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 CDW55550.1 - 2.6 7.8 4.1 2.6 7.7 4.1 1.1 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 CDW55550.1 - 2.6 6.9 5.7 2.9 6.8 5.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4820 PF16091.5 CDW55550.1 - 3.4 7.0 8.9 5.3 6.3 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Zip PF02535.22 CDW55550.1 - 4.6 6.4 5.9 5.3 6.1 5.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter eIF_4EBP PF05456.11 CDW55550.1 - 6.2 6.8 6.6 10 6.1 6.6 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Tim54 PF11711.8 CDW55550.1 - 6.7 5.4 10.9 10 4.8 10.9 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 V_ATPase_I PF01496.19 CDW55550.1 - 8.3 4.2 6.1 8.7 4.1 6.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Copine PF07002.16 CDW55551.1 - 3.1e-60 203.3 0.0 4.8e-60 202.7 0.0 1.3 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 CDW55551.1 - 2.5e-05 24.5 0.0 5.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus Motile_Sperm PF00635.26 CDW55552.1 - 5.1e-10 39.2 0.5 9.7e-10 38.3 0.5 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Vezatin PF12632.7 CDW55554.1 - 1.3e-05 24.8 1.3 1.3e-05 24.8 1.3 2.8 3 0 0 3 3 3 1 Mysoin-binding motif of peroxisomes PBP PF01161.20 CDW55555.1 - 5e-09 36.6 0.0 8.8e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PGM_PMM_I PF02878.16 CDW55556.1 - 1.5e-30 105.7 0.1 2.3e-30 105.1 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDW55556.1 - 4.9e-12 46.1 0.0 9e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDW55556.1 - 6.6e-11 42.7 0.0 1.3e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_I PF02878.16 CDW55558.1 - 3.8e-06 26.7 0.0 4.3e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I DUF608 PF04685.13 CDW55559.1 - 4.5e-146 486.7 6.9 5.7e-146 486.3 6.9 1.1 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 CDW55559.1 - 1.1e-14 54.7 0.1 1.7e-14 54.0 0.1 1.3 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term GDE_C PF06202.14 CDW55559.1 - 0.00054 19.0 0.4 0.0018 17.3 0.4 1.7 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase DUF4818 PF16089.5 CDW55559.1 - 0.1 13.1 0.7 83 3.7 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4818) RUN PF02759.19 CDW55560.1 - 1.3e-07 31.6 0.2 2.3e-07 30.8 0.2 1.3 1 0 0 1 1 1 1 RUN domain Moulting_cycle PF04870.16 CDW55563.1 - 8.8e-27 94.3 1.3 1.8e-26 93.3 1.3 1.6 1 0 0 1 1 1 1 Moulting cycle RGS_DHEX PF18148.1 CDW55564.1 - 4.6e-37 126.1 1.4 1.1e-36 125.0 1.4 1.6 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 CDW55564.1 - 3.4e-33 114.4 0.8 6.9e-33 113.4 0.8 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 CDW55564.1 - 1.4e-08 34.7 0.1 2.4e-06 27.5 0.0 3.2 3 0 0 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 CDW55564.1 - 4e-08 33.1 0.1 4.6e-07 29.7 0.0 2.3 2 0 0 2 2 2 1 GGL domain Dynamin_N PF00350.23 CDW55565.1 - 8.6e-09 35.7 0.0 1.4e-07 31.7 0.0 2.2 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CDW55565.1 - 2.7e-06 27.5 0.0 5.6e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CDW55565.1 - 0.0023 18.3 0.0 0.0039 17.6 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 CDW55565.1 - 0.0068 16.0 0.0 0.077 12.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 CDW55565.1 - 0.014 14.8 0.0 0.027 13.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 CDW55565.1 - 0.038 14.2 0.0 0.18 12.1 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 CDW55565.1 - 0.039 13.7 0.0 2 8.1 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF5600 PF18150.1 CDW55565.1 - 0.066 13.8 0.5 0.14 12.8 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5600) Ras PF00071.22 CDW55565.1 - 0.075 12.6 0.3 1.2 8.7 0.0 2.5 3 0 0 3 3 3 0 Ras family ATPase PF06745.13 CDW55565.1 - 0.12 11.6 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 KaiC zf-RING_2 PF13639.6 CDW55566.1 - 4.9e-06 26.8 5.7 4.9e-06 26.8 5.7 4.1 4 1 0 4 4 4 1 Ring finger domain HscB_4_cys PF18256.1 CDW55566.1 - 1.7 8.5 11.3 2.3 8.1 5.4 3.1 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif wnt PF00110.19 CDW55567.1 - 1.8e-86 290.6 25.7 2.1e-86 290.3 25.7 1.0 1 0 0 1 1 1 1 wnt family SPRY PF00622.28 CDW55568.1 - 3.3e-15 56.2 0.3 9.9e-08 32.1 0.0 2.5 2 0 0 2 2 2 2 SPRY domain Carbam_trans_C PF16861.5 CDW55569.1 - 0.068 12.8 0.0 0.095 12.3 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus HMG_box PF00505.19 CDW55571.1 - 4.7e-27 94.2 2.5 8.9e-27 93.3 2.5 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW55571.1 - 3.7e-11 43.4 1.1 7.9e-11 42.4 1.1 1.6 1 0 0 1 1 1 1 HMG-box domain SOXp PF12336.8 CDW55571.1 - 2.6e-08 34.8 6.1 2.6e-08 34.8 6.1 3.7 4 1 1 5 5 5 1 SOX transcription factor HTH_24 PF13412.6 CDW55571.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding V_ATPase_I PF01496.19 CDW55572.1 - 0.00018 19.6 0.6 0.00018 19.6 0.6 1.9 1 1 1 2 2 2 1 V-type ATPase 116kDa subunit family MAP17 PF15807.5 CDW55572.1 - 0.0079 16.4 5.5 0.0079 16.4 5.5 2.5 1 1 1 2 2 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SID-1_RNA_chan PF13965.6 CDW55572.1 - 0.064 11.7 0.3 0.092 11.1 0.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Mem_trans PF03547.18 CDW55572.1 - 0.093 11.1 0.0 0.1 10.9 0.0 1.1 1 0 0 1 1 1 0 Membrane transport protein Hid1 PF12722.7 CDW55572.1 - 0.12 10.5 9.5 0.16 10.0 9.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 CDW55572.1 - 0.17 11.1 11.6 0.45 9.7 11.6 1.8 1 1 0 1 1 1 0 ZIP Zinc transporter AF-4 PF05110.13 CDW55572.1 - 0.22 9.6 21.2 0.29 9.2 21.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Apt1 PF10351.9 CDW55572.1 - 0.25 10.1 16.5 0.36 9.6 16.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDW55572.1 - 0.33 9.5 10.2 0.42 9.1 10.2 1.1 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 CDW55572.1 - 0.57 7.9 10.5 0.78 7.4 10.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SAPS PF04499.15 CDW55572.1 - 1.8 7.2 9.4 2.8 6.6 9.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM60A PF15396.6 CDW55572.1 - 2.3 8.2 15.8 3.8 7.5 15.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Herpes_DNAp_acc PF04929.12 CDW55572.1 - 2.9 6.8 12.6 4.3 6.2 12.6 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF908 PF06012.12 CDW55572.1 - 3.5 6.9 9.1 6.5 6.1 9.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Neur_chan_memb PF02932.16 CDW55572.1 - 3.7 7.5 7.1 7.1 6.6 7.1 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 CDW55572.1 - 4.9 6.1 13.6 7.5 5.4 13.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF2151 PF10221.9 CDW55572.1 - 5.9 5.4 11.7 9.5 4.7 11.7 1.3 1 0 0 1 1 1 0 Cell cycle and development regulator CDC45 PF02724.14 CDW55572.1 - 6.7 4.9 29.0 11 4.1 29.0 1.2 1 0 0 1 1 1 0 CDC45-like protein HSP20 PF00011.21 CDW55573.1 - 0.00019 21.5 0.0 0.00031 20.8 0.0 1.4 1 1 0 1 1 1 1 Hsp20/alpha crystallin family Phage_FRD3 PF05798.11 CDW55573.1 - 0.091 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage FRD3 protein WD40 PF00400.32 CDW55574.1 - 1.5e-43 145.9 13.5 2.3e-09 37.7 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat Acyltransferase PF01553.21 CDW55574.1 - 2.3e-14 53.2 0.1 5.4e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 Acyltransferase PRP4 PF08799.11 CDW55574.1 - 7.9e-14 50.9 1.5 7.9e-14 50.9 1.5 2.0 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 CDW55574.1 - 6e-11 42.5 0.0 0.0082 16.4 0.0 4.9 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW55574.1 - 0.00044 19.3 1.3 1.8 7.4 0.2 4.5 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDW55574.1 - 0.16 11.2 0.0 8.6 5.6 0.0 2.7 2 1 1 3 3 3 0 WD40-like domain F-box-like PF12937.7 CDW55575.1 - 3.6e-13 49.2 2.0 8.3e-13 48.0 2.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDW55575.1 - 7.5e-07 28.9 0.6 1.6e-06 27.8 0.6 1.6 1 0 0 1 1 1 1 F-box domain TPR_1 PF00515.28 CDW55575.1 - 1.3e-05 24.7 0.3 3.8e-05 23.3 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55575.1 - 2e-05 24.3 0.0 4.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDW55575.1 - 0.00037 20.3 0.0 0.00093 19.1 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW55575.1 - 0.0012 19.3 0.0 0.0031 18.0 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55575.1 - 0.0019 18.3 0.0 0.0042 17.2 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW55575.1 - 0.0079 15.9 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 TPR repeat TPR_14 PF13428.6 CDW55575.1 - 0.0082 16.9 0.0 0.047 14.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 CDW55575.1 - 0.0082 16.2 0.0 0.016 15.3 0.0 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 CDW55575.1 - 0.043 14.1 0.0 0.08 13.2 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TSP_1 PF00090.19 CDW55578.1 - 2.6e-54 181.2 136.6 4e-11 42.9 8.5 9.5 9 1 0 9 9 9 7 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 CDW55578.1 - 1.6e-18 66.9 10.7 3.2e-17 62.8 5.2 6.4 5 2 1 6 6 6 2 ADAM cysteine-rich domain Reprolysin PF01421.19 CDW55578.1 - 1.8e-07 31.3 9.5 3.7e-06 27.0 0.1 3.3 2 1 1 3 3 3 2 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 CDW55578.1 - 1.8e-07 31.5 0.1 1.9e-06 28.2 0.1 2.6 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 CDW55578.1 - 0.00028 21.4 0.0 0.00075 20.0 0.0 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CDW55578.1 - 0.034 13.8 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CDW55578.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Matrixin CLTH PF10607.9 CDW55579.1 - 1.7e-25 89.6 0.3 3.3e-25 88.7 0.3 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SHE3 PF17078.5 CDW55579.1 - 0.0011 18.7 0.9 0.78 9.4 0.1 2.4 2 0 0 2 2 2 2 SWI5-dependent HO expression protein 3 zf-RING_UBOX PF13445.6 CDW55579.1 - 0.0023 17.9 2.1 0.0054 16.7 2.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger DASH_Dad1 PF08649.10 CDW55579.1 - 0.064 13.4 0.0 18 5.6 0.0 2.6 2 0 0 2 2 2 0 DASH complex subunit Dad1 Rtf2 PF04641.12 CDW55579.1 - 0.12 11.8 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_2 PF13639.6 CDW55579.1 - 0.16 12.3 3.7 0.094 13.1 1.0 2.1 2 0 0 2 2 2 0 Ring finger domain Phage_lysozyme2 PF18013.1 CDW55579.1 - 0.19 11.8 0.2 0.64 10.0 0.1 2.0 2 1 0 2 2 2 0 Phage tail lysozyme CPG4 PF15481.6 CDW55580.1 - 0.00018 22.1 6.7 0.11 13.1 0.0 2.7 2 1 0 3 3 3 2 Chondroitin proteoglycan 4 NRN1 PF15056.6 CDW55580.1 - 0.069 13.2 1.1 0.22 11.6 0.1 2.2 2 0 0 2 2 2 0 Neuritin protein family zf-H2C2_2 PF13465.6 CDW55581.1 - 9e-34 114.4 42.2 8.6e-08 32.3 2.9 7.2 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 CDW55581.1 - 1.5e-26 91.3 47.2 4.7e-06 26.8 2.7 6.4 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW55581.1 - 2.7e-22 77.5 44.5 0.00029 21.4 1.1 6.4 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW55581.1 - 2.8e-13 49.8 22.4 0.22 11.9 0.1 6.5 6 0 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW55581.1 - 1.3e-08 34.6 40.1 0.0021 18.0 2.9 6.3 6 0 0 6 6 6 4 C2H2-type zinc finger zf-BED PF02892.15 CDW55581.1 - 0.00028 20.8 24.5 0.073 13.1 1.3 5.6 3 1 3 6 6 6 2 BED zinc finger zf-Di19 PF05605.12 CDW55581.1 - 0.00053 20.2 4.0 0.00053 20.2 4.0 4.2 3 1 1 4 4 4 1 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 CDW55581.1 - 0.00067 20.4 15.4 0.71 10.7 1.4 3.6 1 1 1 3 3 3 2 zinc-ribbon family zf_UBZ PF18439.1 CDW55581.1 - 0.00073 19.1 18.4 0.71 9.5 0.2 6.1 6 0 0 6 6 6 2 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 CDW55581.1 - 0.0014 18.3 24.0 0.1 12.4 0.5 5.5 5 0 0 5 5 5 2 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 CDW55581.1 - 0.003 17.6 24.0 0.1 12.7 2.3 5.2 3 2 3 6 6 6 1 Zinc ribbon domain zf-met PF12874.7 CDW55581.1 - 0.012 16.0 33.9 0.42 11.1 0.0 6.4 6 0 0 6 6 6 0 Zinc-finger of C2H2 type FYDLN_acid PF09538.10 CDW55581.1 - 0.05 14.3 12.2 10 6.9 0.5 5.4 1 1 3 5 5 5 0 Protein of unknown function (FYDLN_acid) zf-CHCC PF10276.9 CDW55581.1 - 0.05 13.7 13.9 0.11 12.6 0.2 3.9 5 0 0 5 5 4 0 Zinc-finger domain zf_C2H2_ZHX PF18387.1 CDW55581.1 - 0.057 13.1 0.2 0.057 13.1 0.2 4.0 3 2 2 5 5 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-AN1 PF01428.16 CDW55581.1 - 0.093 12.9 24.7 8.4 6.7 0.2 6.4 5 1 1 6 6 6 0 AN1-like Zinc finger zf-FPG_IleRS PF06827.14 CDW55581.1 - 0.21 11.5 8.9 16 5.4 0.2 5.2 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS Zn-C2H2_12 PF18112.1 CDW55581.1 - 0.23 11.9 17.0 1 9.9 0.3 5.3 6 0 0 6 6 5 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 CDW55581.1 - 0.41 11.0 27.6 7.8 6.9 7.6 5.4 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 CDW55581.1 - 0.42 10.4 26.6 1.7 8.5 4.3 5.7 5 0 0 5 5 5 0 C2H2-type zinc-finger domain HypA PF01155.19 CDW55581.1 - 0.66 10.0 16.8 1.4 8.9 1.0 3.8 1 1 3 4 4 4 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PyrI_C PF02748.15 CDW55581.1 - 0.82 9.6 13.0 2.2 8.2 0.1 5.3 5 1 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain HalOD2 PF18547.1 CDW55581.1 - 1.1 9.2 8.6 13 5.7 0.1 3.7 2 1 1 3 3 3 0 Halobacterial output domain 2 Prok-RING_1 PF14446.6 CDW55581.1 - 1.2 9.1 18.3 8.1 6.5 0.1 5.4 5 1 0 5 5 4 0 Prokaryotic RING finger family 1 zf-C2H2_3rep PF18868.1 CDW55581.1 - 1.2 9.8 18.7 4.8 7.9 12.0 4.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats XPA_N PF01286.18 CDW55581.1 - 1.4 9.0 20.8 12 6.0 0.1 6.1 6 0 0 6 6 6 0 XPA protein N-terminal YhfH PF14149.6 CDW55581.1 - 1.6 8.8 9.9 26 4.9 0.1 4.5 5 0 0 5 5 5 0 YhfH-like protein zf-C2HE PF16278.5 CDW55581.1 - 1.7 9.1 29.2 0.33 11.4 1.0 6.5 1 1 4 6 6 6 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.11 CDW55581.1 - 1.9 8.5 25.9 3.8 7.5 0.2 6.2 6 0 0 6 6 6 0 LYAR-type C2HC zinc finger RNA_POL_M_15KD PF02150.16 CDW55581.1 - 2.4 8.1 7.9 14 5.7 0.1 3.8 5 0 0 5 5 4 0 RNA polymerases M/15 Kd subunit GAGA PF09237.11 CDW55581.1 - 2.5 8.0 14.1 6.2 6.7 0.0 5.4 3 1 3 6 6 6 0 GAGA factor CpXC PF14353.6 CDW55581.1 - 3.5 7.7 19.4 22 5.1 0.4 5.4 1 1 4 5 5 5 0 CpXC protein FYVE PF01363.21 CDW55581.1 - 5.3 7.3 29.6 1.8e+04 -11.4 29.9 4.1 1 1 0 1 1 0 0 FYVE zinc finger DUF3268 PF11672.8 CDW55581.1 - 5.5 7.3 13.3 4.2 7.7 0.5 3.8 2 2 3 5 5 5 0 zinc-finger-containing domain Cys_rich_CPXG PF14255.6 CDW55581.1 - 8.3 6.4 11.6 8 6.4 1.2 3.9 3 2 1 4 4 4 0 Cysteine-rich CPXCG ADK_lid PF05191.14 CDW55581.1 - 8.4 6.5 16.5 42 4.2 0.2 4.3 3 1 0 3 3 3 0 Adenylate kinase, active site lid Yippee-Mis18 PF03226.14 CDW55581.1 - 9 6.6 12.1 12 6.1 0.9 2.8 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PAN_1 PF00024.26 CDW55582.1 - 1.4e-06 28.2 2.5 0.018 15.0 0.3 2.7 2 0 0 2 2 2 2 PAN domain PAN_3 PF08277.12 CDW55582.1 - 0.035 13.9 4.6 1.5 8.7 0.1 3.1 3 0 0 3 3 3 0 PAN-like domain Rab5ip PF07019.12 CDW55583.1 - 1.1e-17 64.3 8.8 2.1e-17 63.5 8.8 1.5 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) S4 PF01479.25 CDW55583.1 - 2.3e-10 40.0 0.0 1.2e-09 37.7 0.0 2.2 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 CDW55583.1 - 8e-06 26.7 0.2 1.5e-05 25.8 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Tsp45I PF06300.12 CDW55583.1 - 0.048 13.2 0.0 0.75 9.3 0.0 2.0 2 0 0 2 2 2 0 Tsp45I type II restriction enzyme Occludin_ELL PF07303.13 CDW55583.1 - 0.067 13.9 0.1 0.14 12.9 0.1 1.5 1 0 0 1 1 1 0 Occludin homology domain Mur_ligase_M PF08245.12 CDW55584.1 - 2.7e-06 27.5 0.0 6e-05 23.1 0.0 2.5 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 CDW55584.1 - 0.006 16.8 0.0 0.02 15.2 0.0 1.9 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain MMR_HSR1 PF01926.23 CDW55585.1 - 7.5e-15 55.0 0.0 5.2e-14 52.3 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW55585.1 - 6.4e-07 29.0 0.0 7.8e-06 25.5 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDW55585.1 - 8.1e-05 22.6 0.1 0.0059 16.5 0.1 2.4 1 1 1 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CDW55585.1 - 0.0017 17.8 0.0 0.0037 16.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 CDW55585.1 - 0.18 11.9 0.3 1.2 9.2 0.2 2.4 1 1 1 2 2 2 0 Dynamin family Pkinase PF00069.25 CDW55586.1 - 2.1e-61 207.6 0.0 3.5e-60 203.6 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55586.1 - 1.3e-29 103.3 0.0 3.5e-20 72.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDW55586.1 - 7.2e-05 22.2 0.0 0.0012 18.2 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW55586.1 - 0.00043 19.3 0.1 0.00069 18.7 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDW55586.1 - 0.00055 19.9 0.5 0.02 14.8 0.5 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family UBA PF00627.31 CDW55586.1 - 0.0022 17.9 0.0 0.0046 16.8 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Kdo PF06293.14 CDW55586.1 - 0.0034 16.8 0.1 0.0065 15.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 CDW55586.1 - 0.06 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_C PF00433.24 CDW55586.1 - 0.35 11.6 1.5 0.86 10.4 1.5 1.7 1 0 0 1 1 1 0 Protein kinase C terminal domain zf-H2C2_2 PF13465.6 CDW55588.1 - 1.3e-07 31.7 15.8 3.7e-05 24.0 3.4 4.2 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 CDW55588.1 - 0.0017 18.7 32.1 0.27 11.8 6.5 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-Di19 PF05605.12 CDW55588.1 - 0.016 15.5 14.5 0.46 10.8 8.6 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CDW55588.1 - 0.28 12.2 32.4 1.4 9.9 6.0 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger Trypsin PF00089.26 CDW55589.1 - 1.8e-40 139.1 0.1 2.2e-40 138.9 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW55589.1 - 1.4e-05 26.0 0.0 2.2e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW55589.1 - 0.014 15.8 0.1 0.031 14.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1986) Trypsin PF00089.26 CDW55590.1 - 1.9e-267 881.3 23.2 1.3e-43 149.4 0.2 13.7 8 6 1 9 9 9 8 Trypsin Trypsin_2 PF13365.6 CDW55590.1 - 8.7e-51 172.8 0.0 4.9e-06 27.5 0.0 8.9 8 1 0 8 8 8 8 Trypsin-like peptidase domain DUF2439 PF10382.9 CDW55590.1 - 0.35 11.2 6.1 7.1 7.0 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF2439) Nucleoporin_C PF03177.14 CDW55591.1 - 0.00017 20.5 5.2 0.0042 15.9 0.1 3.1 1 1 0 3 3 3 2 Non-repetitive/WGA-negative nucleoporin C-terminal Furin-like PF00757.20 CDW55591.1 - 0.16 11.9 0.1 0.37 10.7 0.1 1.6 1 0 0 1 1 1 0 Furin-like cysteine rich region Pkinase PF00069.25 CDW55592.1 - 5.4e-62 209.5 0.0 7.1e-62 209.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55592.1 - 7.6e-36 123.7 0.0 1.2e-35 123.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW55592.1 - 0.00039 19.3 0.0 0.00082 18.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDW55592.1 - 0.022 14.1 0.1 0.094 12.0 0.1 1.8 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 CDW55592.1 - 0.035 14.0 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family PRELI PF04707.14 CDW55593.1 - 3e-38 131.1 0.0 3.6e-38 130.8 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family ATP-synt_E PF05680.12 CDW55594.1 - 3.7e-11 43.2 0.1 4.5e-11 42.9 0.1 1.2 1 0 0 1 1 1 1 ATP synthase E chain Tetraspanin PF00335.20 CDW55595.1 - 7.9e-37 127.2 14.2 9.1e-37 127.0 14.2 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2892 PF11127.8 CDW55595.1 - 2.5 8.2 12.1 2.3 8.3 6.6 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF2892) DUF2304 PF10066.9 CDW55595.1 - 3.3 8.0 7.2 0.65 10.3 2.9 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) 7tm_1 PF00001.21 CDW55596.1 - 1.7e-58 198.0 15.5 4.6e-53 180.2 9.8 2.4 2 1 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW55596.1 - 5.5e-07 29.2 15.9 5.5e-07 29.2 15.9 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW55596.1 - 3.5e-06 26.8 17.2 3.5e-06 26.8 17.2 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 CDW55596.1 - 0.016 15.0 16.7 0.23 11.1 12.6 3.0 3 1 0 3 3 3 0 Olfactory receptor DUF5466 PF17554.2 CDW55596.1 - 0.028 14.6 0.7 0.028 14.6 0.7 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5466) DUF4239 PF14023.6 CDW55596.1 - 0.093 12.4 0.7 0.27 10.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) LEM PF03020.15 CDW55597.1 - 1e-16 60.2 0.8 1.4e-16 59.8 0.0 1.6 2 0 0 2 2 2 1 LEM domain FeoA PF04023.14 CDW55597.1 - 0.082 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 FeoA domain KaiB PF07689.12 CDW55597.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 KaiB domain Helicase_C PF00271.31 CDW55598.1 - 3e-32 111.3 0.0 4.9e-32 110.6 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-CCHC PF00098.23 CDW55598.1 - 0.00012 22.0 2.3 0.00022 21.1 2.3 1.5 1 0 0 1 1 1 1 Zinc knuckle APH PF01636.23 CDW55598.1 - 0.014 15.3 0.1 0.018 15.0 0.1 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family UTP25 PF06862.12 CDW55598.1 - 0.028 13.2 0.0 0.035 12.9 0.0 1.1 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ERCC3_RAD25_C PF16203.5 CDW55598.1 - 0.082 12.1 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-CCHC_4 PF14392.6 CDW55598.1 - 0.11 12.3 0.8 0.2 11.4 0.8 1.5 1 0 0 1 1 1 0 Zinc knuckle MOFRL PF05161.13 CDW55598.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 MOFRL family EB PF01683.18 CDW55599.1 - 0.021 15.1 19.8 0.099 13.0 4.3 2.3 2 0 0 2 2 2 0 EB module Phytochelatin_C PF09328.10 CDW55599.1 - 0.063 12.6 1.7 0.069 12.5 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1984) Dickkopf_N PF04706.12 CDW55599.1 - 4.7 7.8 21.8 1.1 9.8 8.5 2.9 1 1 1 2 2 2 0 Dickkopf N-terminal cysteine-rich region WRKY PF03106.15 CDW55601.1 - 0.00085 19.5 2.9 0.083 13.1 0.7 2.6 2 0 0 2 2 2 2 WRKY DNA -binding domain JmjC PF02373.22 CDW55602.1 - 4.9e-39 133.3 1.3 1e-38 132.3 1.3 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 CDW55602.1 - 9.4e-22 77.3 6.7 9.4e-22 77.3 6.7 3.0 3 0 0 3 3 3 1 PHD-zinc-finger like domain JmjN PF02375.17 CDW55602.1 - 1.9e-13 50.1 0.1 4.1e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H PF13771.6 CDW55602.1 - 4.2e-13 49.4 3.8 4.2e-13 49.4 3.8 3.3 2 1 0 2 2 2 1 PHD-like zinc-binding domain Tudor_2 PF18104.1 CDW55602.1 - 1.7e-08 34.0 3.8 0.0019 17.9 0.1 3.0 2 0 0 2 2 2 2 Jumonji domain-containing protein 2A Tudor domain PHD_2 PF13831.6 CDW55602.1 - 1.8e-08 33.8 4.3 1.8e-08 33.8 4.3 3.8 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 CDW55602.1 - 3.5e-07 30.0 20.0 3.4e-06 26.8 1.9 4.2 3 1 0 3 3 3 2 PHD-finger PHD_4 PF16866.5 CDW55602.1 - 4.5e-05 23.5 6.2 4.5e-05 23.5 6.2 3.1 3 1 0 3 3 3 1 PHD-finger C1_1 PF00130.22 CDW55602.1 - 0.73 9.8 25.4 0.18 11.7 2.0 5.0 3 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) VRR_NUC PF08774.11 CDW55603.1 - 1.4e-19 70.2 0.0 2.3e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 VRR-NUC domain GATase_6 PF13522.6 CDW55604.1 - 3.5e-17 62.9 0.0 6.9e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CDW55604.1 - 4.5e-14 52.4 0.0 1e-13 51.3 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 CDW55604.1 - 1.1e-05 25.0 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 CDW55604.1 - 0.00059 18.8 0.0 0.00094 18.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Cadherin PF00028.17 CDW55605.1 - 1.7e-68 227.1 0.0 1.5e-18 67.0 0.0 6.2 6 1 0 6 6 6 5 Cadherin domain Cadherin_2 PF08266.12 CDW55605.1 - 5.3e-05 23.0 0.0 0.64 9.9 0.0 4.8 4 1 0 4 4 4 2 Cadherin-like Cadherin_4 PF17803.1 CDW55605.1 - 0.013 16.1 5.0 4.3 8.1 0.0 3.9 3 0 0 3 3 3 0 Bacterial cadherin-like domain RET_CLD1 PF17756.1 CDW55605.1 - 0.023 15.0 0.0 0.82 10.0 0.0 2.7 2 0 0 2 2 2 0 RET Cadherin like domain 1 Oscp1 PF10188.9 CDW55606.1 - 8.1e-62 208.4 5.8 1.2e-61 207.8 5.8 1.3 1 0 0 1 1 1 1 Organic solute transport protein 1 Cadherin PF00028.17 CDW55607.1 - 0 1072.5 16.3 4.7e-19 68.6 0.0 22.3 22 0 0 22 22 22 22 Cadherin domain RET_CLD1 PF17756.1 CDW55607.1 - 1.3e-15 57.8 0.0 0.027 14.8 0.0 10.9 13 0 0 13 13 13 3 RET Cadherin like domain 1 Cadherin_2 PF08266.12 CDW55607.1 - 1.3e-14 53.8 0.0 52 3.8 0.0 15.2 19 0 0 19 19 19 0 Cadherin-like Cadherin_3 PF16184.5 CDW55607.1 - 2.6e-11 43.5 23.3 0.031 14.3 0.0 12.9 15 1 2 17 17 17 3 Cadherin-like Cadherin_pro PF08758.11 CDW55607.1 - 9.5e-10 38.5 0.0 0.26 11.5 0.0 8.1 9 0 0 9 9 9 2 Cadherin prodomain like Cadherin_4 PF17803.1 CDW55607.1 - 8.5e-07 29.5 39.8 1.3 9.7 0.4 11.1 11 0 0 11 11 11 4 Bacterial cadherin-like domain He_PIG PF05345.12 CDW55607.1 - 0.049 13.8 8.6 16 5.8 0.0 7.4 9 0 0 9 9 9 0 Putative Ig domain RNA_pol_Rbc25 PF08292.12 CDW55608.1 - 3.1e-33 114.7 0.1 4.5e-33 114.2 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 CDW55608.1 - 2.2e-11 43.9 0.1 3.8e-11 43.2 0.1 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 CDW55608.1 - 0.0086 16.4 0.0 0.014 15.7 0.0 1.5 1 1 0 1 1 1 1 S1 RNA binding domain Metallophos PF00149.28 CDW55609.1 - 7.7e-37 127.8 0.2 9.5e-37 127.5 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ribosomal_L16 PF00252.18 CDW55610.1 - 1.5e-43 148.0 0.1 1.9e-43 147.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e UPF0669 PF17065.5 CDW55611.1 - 1.3e-25 90.2 0.0 1.4e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Putative cytokine, C6ORF120 zf-HC5HC2H PF13771.6 CDW55612.1 - 3.6e-06 27.1 9.6 3.8e-06 27.1 7.2 2.4 2 1 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CDW55612.1 - 4.4e-06 26.8 5.9 2.7e-05 24.3 5.6 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain YibE_F PF07907.11 CDW55613.1 - 0.017 14.6 0.4 0.028 13.9 0.0 1.5 2 0 0 2 2 2 0 YibE/F-like protein Uteroglobin PF01099.17 CDW55613.1 - 0.68 10.3 5.3 4.5 7.7 1.0 2.9 2 1 0 2 2 2 0 Uteroglobin family Pet191_N PF10203.9 CDW55613.1 - 2.6 8.4 9.1 15 6.0 1.2 3.2 2 2 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DUF5446 PF17522.2 CDW55613.1 - 3.4 7.9 12.5 0.29 11.3 3.3 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5446) Mito_carr PF00153.27 CDW55614.1 - 3.8e-55 183.8 3.1 2.3e-19 69.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Fzo_mitofusin PF04799.13 CDW55615.1 - 3.1e-37 127.6 1.5 1.8e-36 125.1 0.0 2.6 2 0 0 2 2 2 1 fzo-like conserved region Dynamin_N PF00350.23 CDW55615.1 - 6.1e-24 85.0 1.4 1.5e-23 83.7 0.0 2.4 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 CDW55615.1 - 2.7e-08 33.9 0.0 1.7e-07 31.3 0.0 2.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase KorB PF08535.10 CDW55615.1 - 0.009 16.0 2.4 3.6 7.7 0.0 3.6 3 0 0 3 3 3 1 KorB domain KxDL PF10241.9 CDW55615.1 - 0.033 14.5 3.6 12 6.3 0.0 4.3 3 0 0 3 3 3 0 Uncharacterized conserved protein Apolipoprotein PF01442.18 CDW55615.1 - 0.043 13.7 2.9 0.75 9.6 0.5 2.7 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain RsgA_GTPase PF03193.16 CDW55615.1 - 0.055 13.4 1.4 0.32 10.9 0.0 2.8 3 0 0 3 3 3 0 RsgA GTPase Cas6_N PF17952.1 CDW55615.1 - 0.08 13.2 2.7 0.87 9.9 0.5 3.2 3 1 1 4 4 4 0 Cas6 N-terminal domain FtsK_SpoIIIE PF01580.18 CDW55615.1 - 0.099 12.0 1.7 1.8 7.8 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AIG1 PF04548.16 CDW55615.1 - 0.12 11.7 0.1 0.12 11.7 0.1 3.2 3 0 0 3 3 3 0 AIG1 family MIT_C PF16565.5 CDW55615.1 - 0.17 11.9 2.8 0.99 9.4 1.2 2.7 3 0 0 3 3 3 0 Phospholipase D-like domain at C-terminus of MIT YtxH PF12732.7 CDW55615.1 - 0.48 11.0 3.1 13 6.4 0.1 3.5 3 1 0 3 3 2 0 YtxH-like protein COG5 PF10392.9 CDW55615.1 - 0.56 10.4 8.3 3.3 7.9 0.3 4.0 3 1 1 4 4 4 0 Golgi transport complex subunit 5 TBCA PF02970.16 CDW55615.1 - 2 8.8 6.9 3.6 8.0 0.6 3.5 3 0 0 3 3 3 0 Tubulin binding cofactor A Baculo_PEP_C PF04513.12 CDW55615.1 - 2.2 8.3 3.9 2 8.5 0.5 2.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 CDW55615.1 - 4.3 7.4 8.3 1.6 8.8 0.6 3.7 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) WD40 PF00400.32 CDW55616.1 - 2.5e-11 43.9 10.6 0.001 19.8 0.1 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat WD40_like PF17005.5 CDW55616.1 - 0.00058 19.3 0.1 0.33 10.2 0.2 2.5 1 1 1 2 2 2 2 WD40-like domain Alpha-amyl_C PF09071.10 CDW55616.1 - 0.23 11.3 0.5 17 5.4 0.1 2.7 3 0 0 3 3 3 0 Alpha-amylase, C terminal zf-MIZ PF02891.20 CDW55617.1 - 1.8e-16 59.6 5.1 4.2e-16 58.4 5.1 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CDW55617.1 - 1.1e-05 25.2 3.3 1.1e-05 25.2 3.3 2.1 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-Di19 PF05605.12 CDW55618.1 - 7.3e-17 61.4 3.7 7.3e-17 61.4 3.7 1.9 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.17 CDW55618.1 - 0.00012 21.8 2.4 0.00012 21.8 2.4 2.8 4 0 0 4 4 4 1 Zinc finger, ZZ type zf-ribbon_3 PF13248.6 CDW55618.1 - 0.035 13.5 3.6 4.2 6.9 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain Elf1 PF05129.13 CDW55618.1 - 0.57 10.3 2.9 0.65 10.1 1.0 2.0 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_4 PF13894.6 CDW55618.1 - 4.3 8.4 12.5 1.7 9.7 1.3 4.0 3 1 0 3 3 3 0 C2H2-type zinc finger zf-nanos PF05741.13 CDW55618.1 - 5.3 7.3 8.5 5.1 7.4 4.9 2.6 2 1 1 3 3 3 0 Nanos RNA binding domain DUF572 PF04502.13 CDW55619.1 - 8.6e-79 265.5 5.5 1.1e-78 265.3 5.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Zn-ribbon_8 PF09723.10 CDW55619.1 - 0.099 12.8 1.5 0.23 11.6 0.4 2.1 2 0 0 2 2 2 0 Zinc ribbon domain Homeodomain PF00046.29 CDW55620.1 - 1.2e-23 82.7 1.7 1.7e-23 82.2 1.7 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW55620.1 - 0.0027 17.6 0.1 0.0062 16.4 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 CDW55620.1 - 0.041 13.4 0.6 0.098 12.1 0.1 1.9 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez HPP PF04982.13 CDW55621.1 - 0.038 14.2 1.3 0.042 14.0 0.0 1.7 2 0 0 2 2 2 0 HPP family DUF913 PF06025.12 CDW55622.1 - 0.023 13.7 0.4 0.025 13.6 0.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 CDW55622.1 - 3.5 6.3 5.8 4.3 6.0 5.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CD20 PF04103.15 CDW55623.1 - 6.6e-05 23.0 11.8 6.6e-05 23.0 11.8 2.2 1 1 1 2 2 2 2 CD20-like family BCLP PF12304.8 CDW55623.1 - 0.0018 17.9 5.4 0.0018 17.9 5.4 2.2 1 1 1 2 2 2 1 Beta-casein like protein Phage_holin_3_6 PF07332.11 CDW55623.1 - 0.024 14.7 13.4 0.57 10.2 5.5 2.2 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Glycophorin_A PF01102.18 CDW55623.1 - 0.3 11.3 1.7 0.36 11.1 0.6 1.7 1 1 1 2 2 2 0 Glycophorin A DUF308 PF03729.13 CDW55623.1 - 4.7 7.6 19.3 6.7 7.1 15.2 2.7 2 1 1 3 3 3 0 Short repeat of unknown function (DUF308) Mannosyl_trans PF05007.13 CDW55624.1 - 2.4e-70 237.3 26.7 2.4e-70 237.3 26.7 1.9 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) Sarcoglycan_1 PF04790.13 CDW55624.1 - 1.1e-51 175.7 0.1 1.8e-51 175.0 0.1 1.3 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein TP_methylase PF00590.20 CDW55624.1 - 9.3e-17 61.7 0.0 2e-16 60.6 0.0 1.6 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF1241 PF06840.11 CDW55625.1 - 6.2e-43 146.0 0.2 8.2e-43 145.6 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Ran-binding PF05508.11 CDW55625.1 - 0.099 11.6 0.3 0.16 10.9 0.2 1.4 1 1 0 1 1 1 0 RanGTP-binding protein Focal_AT PF03623.13 CDW55625.1 - 0.16 12.0 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Focal adhesion targeting region Atrophin-1 PF03154.15 CDW55626.1 - 3.5e-11 42.2 25.1 3.1e-10 39.1 4.2 5.7 3 2 2 6 6 6 3 Atrophin-1 family ELM2 PF01448.24 CDW55626.1 - 8.6e-11 42.4 0.5 3.1e-10 40.6 0.0 2.3 2 0 0 2 2 2 1 ELM2 domain GATA PF00320.27 CDW55626.1 - 1.1e-07 31.4 4.5 1.1e-07 31.4 4.5 2.0 2 0 0 2 2 2 1 GATA zinc finger Myb_DNA-bind_7 PF15963.5 CDW55626.1 - 0.0022 17.8 1.0 0.0022 17.8 1.0 2.0 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 CDW55626.1 - 0.022 15.0 0.2 0.068 13.4 0.2 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Dicty_REP PF05086.12 CDW55626.1 - 0.3 9.0 0.9 0.44 8.5 0.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Suf PF05843.14 CDW55626.1 - 8.8 6.2 7.1 2.1 8.3 2.1 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) UPF0561 PF10573.9 CDW55627.1 - 0.15 12.2 1.0 0.26 11.4 1.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Nipped-B_C PF12830.7 CDW55629.1 - 3.3e-58 196.8 2.5 9.4e-58 195.3 0.8 2.5 2 1 0 2 2 2 1 Sister chromatid cohesion C-terminus Cnd1 PF12717.7 CDW55629.1 - 2e-07 31.2 0.9 0.007 16.4 0.3 3.1 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDW55629.1 - 8.7e-05 21.3 2.6 8.7e-05 21.3 2.6 1.8 2 0 0 2 2 2 1 Adaptin N terminal region HEAT PF02985.22 CDW55629.1 - 0.00027 20.9 3.6 0.84 10.1 0.1 4.8 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 CDW55629.1 - 0.00042 20.6 0.1 1.2 9.5 0.0 3.3 3 0 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 CDW55629.1 - 0.0026 18.2 0.2 0.23 12.0 0.0 3.8 4 0 0 4 4 4 1 HEAT-like repeat FTCD_C PF04961.12 CDW55629.1 - 0.014 15.2 0.1 0.029 14.1 0.1 1.5 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Cohesin_HEAT PF12765.7 CDW55629.1 - 0.12 12.7 4.0 6.9 7.1 0.1 4.3 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion RasGEF_N_2 PF14663.6 CDW55629.1 - 0.35 11.3 2.5 12 6.4 0.0 4.5 5 1 1 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Ribosomal_L24e PF01246.20 CDW55631.1 - 6.8e-31 106.3 6.4 6.8e-31 106.3 6.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e DUF3141 PF11339.8 CDW55631.1 - 0.074 11.5 0.0 0.1 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Glutaredoxin PF00462.24 CDW55632.1 - 6.3e-18 64.7 0.1 8.6e-18 64.3 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 CDW55632.1 - 0.012 16.0 0.1 0.018 15.5 0.1 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_7 PF13899.6 CDW55633.1 - 6.3e-13 48.7 0.0 8.9e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 CDW55633.1 - 7.4e-05 22.7 0.1 9.8e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CDW55633.1 - 0.0022 18.3 0.0 0.0034 17.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CDW55633.1 - 0.0042 16.8 0.0 0.0053 16.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 CDW55633.1 - 0.0049 17.3 0.0 0.0065 16.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDW55633.1 - 0.025 14.3 0.0 0.03 14.1 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin AhpC-TSA PF00578.21 CDW55633.1 - 0.046 13.7 0.0 0.047 13.6 0.0 1.1 1 0 0 1 1 1 0 AhpC/TSA family DUF953 PF06110.11 CDW55633.1 - 0.16 11.6 1.0 0.24 11.0 0.2 1.5 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Proteasome PF00227.26 CDW55635.1 - 1.8e-30 105.8 2.7 4.7e-29 101.2 2.7 2.1 1 1 0 1 1 1 1 Proteasome subunit Plexin_cytopl PF08337.12 CDW55636.1 - 3e-186 620.4 0.0 3.8e-186 620.1 0.0 1.1 1 0 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 CDW55636.1 - 8e-41 140.2 0.0 3.6e-40 138.1 0.0 1.9 1 1 0 1 1 1 1 Sema domain TIG PF01833.24 CDW55636.1 - 1.5e-39 134.0 7.7 3.1e-11 43.2 0.2 5.8 5 0 0 5 5 5 5 IPT/TIG domain TIG_plexin PF17960.1 CDW55636.1 - 4e-16 58.8 0.1 3e-15 56.0 0.0 2.7 2 0 0 2 2 2 1 TIG domain PSI PF01437.25 CDW55636.1 - 2.9e-14 53.3 49.2 1.7e-08 34.9 10.7 3.9 3 0 0 3 3 3 3 Plexin repeat TIG_2 PF18020.1 CDW55636.1 - 2.1e-12 47.5 0.3 1.5e-11 44.8 0.1 2.4 2 0 0 2 2 2 1 TIG domain found in plexin PSI_integrin PF17205.3 CDW55636.1 - 4 7.3 44.5 0.11 12.3 9.6 3.9 3 0 0 3 3 3 0 Integrin plexin domain Myb_DNA-binding PF00249.31 CDW55639.1 - 5.5e-17 61.7 1.6 6e-11 42.4 0.2 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain DnaJ PF00226.31 CDW55639.1 - 1.5e-13 50.6 0.1 3.8e-13 49.3 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain Myb_DNA-bind_6 PF13921.6 CDW55639.1 - 8.2e-12 45.2 3.2 1.3e-05 25.3 0.4 3.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain RAC_head PF16717.5 CDW55639.1 - 1.8e-05 25.6 0.1 1.8e-05 25.6 0.1 3.2 1 1 1 2 2 2 1 Ribosome-associated complex head domain Baculo_LEF-11 PF06385.12 CDW55639.1 - 0.014 15.9 0.0 0.45 11.1 0.0 2.9 2 1 0 2 2 2 0 Baculovirus LEF-11 protein Glyco_transf_8 PF01501.20 CDW55640.1 - 3.1e-10 40.0 0.6 4.8e-10 39.4 0.6 1.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Npa1 PF11707.8 CDW55640.1 - 0.052 12.9 0.1 0.083 12.2 0.1 1.2 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal Thioredoxin_7 PF13899.6 CDW55642.1 - 4.2e-13 49.3 0.1 1.3e-12 47.7 0.1 1.9 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 CDW55642.1 - 2.1e-09 37.4 0.0 3.8e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 UBX domain KR PF08659.10 CDW55642.1 - 0.028 14.3 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 KR domain PID_2 PF14719.6 CDW55643.1 - 9e-73 244.0 1.0 1.2e-72 243.6 1.0 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF2724 PF10893.8 CDW55643.1 - 0.12 12.2 0.0 0.36 10.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2724) CAP_N PF01213.19 CDW55644.1 - 8.9e-87 291.5 1.2 1.7e-65 221.6 0.1 2.4 2 0 0 2 2 2 2 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 CDW55644.1 - 1.8e-53 180.4 3.6 1.9e-49 167.3 2.5 2.2 2 0 0 2 2 2 2 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 CDW55644.1 - 0.00015 21.4 4.4 0.00074 19.2 3.8 2.2 1 1 1 2 2 2 2 Tubulin binding cofactor C PRIMA1 PF16101.5 CDW55644.1 - 0.11 12.5 3.4 0.31 11.1 3.4 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF4124 PF13511.6 CDW55644.1 - 0.12 12.7 0.7 0.43 11.0 0.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) COPIIcoated_ERV PF07970.12 CDW55645.1 - 9.7e-74 247.9 0.0 1.4e-73 247.4 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CDW55645.1 - 6.6e-29 100.1 0.4 6.6e-29 100.1 0.4 2.4 3 0 0 3 3 3 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF3456 PF11938.8 CDW55645.1 - 8.4e-23 81.6 0.1 1.6e-22 80.7 0.1 1.3 1 0 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Med31 PF05669.12 CDW55645.1 - 8.8e-07 28.9 0.1 2e-06 27.7 0.1 1.6 1 0 0 1 1 1 1 SOH1 DUF1563 PF07599.11 CDW55645.1 - 0.09 12.9 0.3 1 9.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) DUF4211 PF13926.6 CDW55645.1 - 0.11 12.6 0.1 0.75 9.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4211) Romo1 PF10247.9 CDW55646.1 - 4e-25 88.0 11.4 5.1e-25 87.6 11.4 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 CDW55646.1 - 4.3e-05 23.8 4.7 4.8e-05 23.7 4.7 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Cpn60_TCP1 PF00118.24 CDW55647.1 - 1.7e-146 488.7 14.4 3.6e-141 471.2 11.8 2.0 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family NAD_binding_7 PF13241.6 CDW55647.1 - 0.11 12.9 0.8 0.5 10.8 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Med27 PF11571.8 CDW55648.1 - 2.3e-18 66.4 2.8 5e-18 65.2 1.4 2.1 2 0 0 2 2 2 1 Mediator complex subunit 27 OST3_OST6 PF04756.13 CDW55649.1 - 1.1e-86 290.8 0.5 1.4e-86 290.5 0.5 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF4131 PF13567.6 CDW55649.1 - 0.096 12.3 5.8 2.7 7.6 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Gram_pos_anchor PF00746.21 CDW55649.1 - 0.37 10.8 1.7 9.1 6.3 0.5 2.7 3 0 0 3 3 3 0 LPXTG cell wall anchor motif Pyr_redox_2 PF07992.14 CDW55650.1 - 0.00031 20.1 0.3 0.0064 15.8 0.3 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase rOmpB PF12334.8 CDW55650.1 - 0.016 14.7 0.2 0.028 13.9 0.2 1.5 1 0 0 1 1 1 0 Rickettsia outer membrane protein B Rubredoxin_C PF18267.1 CDW55650.1 - 0.017 15.0 0.0 0.036 14.0 0.0 1.6 1 0 0 1 1 1 0 Rubredoxin NAD+ reductase C-terminal domain TMEM126 PF07114.11 CDW55652.1 - 5.5e-06 25.9 0.7 7.2e-06 25.5 0.7 1.2 1 0 0 1 1 1 1 Transmembrane protein 126 Galactosyl_T PF01762.21 CDW55653.1 - 3.1e-26 92.4 0.0 4.7e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Sybindin PF04099.12 CDW55655.1 - 9.9e-46 155.2 0.0 1.2e-45 155.0 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CDW55655.1 - 2.1e-06 27.9 0.0 3.7e-06 27.1 0.0 1.4 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region WWE PF02825.20 CDW55656.1 - 3.7e-14 53.1 0.1 5.3e-14 52.6 0.1 1.2 1 0 0 1 1 1 1 WWE domain zf-C3HC4_3 PF13920.6 CDW55656.1 - 8.8e-07 28.7 8.9 1.9e-06 27.6 8.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW55656.1 - 2.2e-06 27.9 10.6 5.8e-06 26.5 10.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CDW55656.1 - 4.4e-06 26.5 10.2 4.4e-06 26.5 10.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDW55656.1 - 4.5e-05 23.2 11.9 4.5e-05 23.2 11.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW55656.1 - 6.4e-05 22.7 11.1 6.4e-05 22.7 11.1 2.1 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CDW55656.1 - 0.00038 20.3 10.5 0.00038 20.3 10.5 2.2 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDW55656.1 - 0.0018 18.4 14.2 0.0018 18.4 14.2 2.1 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CDW55656.1 - 0.0051 16.8 18.2 0.084 12.9 18.2 2.4 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 CDW55656.1 - 0.0068 16.2 1.5 0.0068 16.2 1.5 2.2 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CDW55656.1 - 1.3 9.4 12.8 0.24 11.7 8.4 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain SURF1 PF02104.15 CDW55657.1 - 4.4e-36 124.8 0.0 5.1e-36 124.5 0.0 1.0 1 0 0 1 1 1 1 SURF1 family Ribonuclease_3 PF00636.26 CDW55659.1 - 3.8e-49 165.7 0.1 8.3e-25 87.4 0.0 3.7 4 0 0 4 4 4 2 Ribonuclease III domain Dicer_dimer PF03368.14 CDW55659.1 - 1.4e-25 89.2 0.5 1e-24 86.5 0.4 2.6 2 0 0 2 2 2 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 CDW55659.1 - 8.4e-23 80.9 0.0 4.5e-16 59.2 0.0 4.5 3 1 0 3 3 3 2 Ribonuclease-III-like Helicase_C PF00271.31 CDW55659.1 - 8.4e-16 58.3 0.1 2.1e-15 57.0 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PAZ PF02170.22 CDW55659.1 - 4.8e-12 45.9 0.0 1.1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 PAZ domain ResIII PF04851.15 CDW55659.1 - 1.2e-08 35.1 0.1 0.00018 21.6 0.0 2.5 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit dsrm PF00035.26 CDW55659.1 - 9.5e-05 23.0 0.5 0.14 12.8 0.1 2.6 2 0 0 2 2 2 2 Double-stranded RNA binding motif DEAD PF00270.29 CDW55659.1 - 0.00024 20.9 0.4 0.033 13.9 0.0 2.5 1 1 1 2 2 2 1 DEAD/DEAH box helicase MOSC PF03473.17 CDW55660.1 - 8.8e-26 90.5 0.0 1.6e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 MOSC domain Aminotran_5 PF00266.19 CDW55660.1 - 7.9e-23 81.0 0.0 4.5e-14 52.2 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class-V MOSC_N PF03476.16 CDW55660.1 - 1.6e-12 47.3 0.1 2.2e-10 40.5 0.1 2.4 1 1 0 1 1 1 1 MOSC N-terminal beta barrel domain IQ_SEC7_PH PF16453.5 CDW55660.1 - 0.2 11.6 0.1 4.8 7.1 0.0 2.6 3 0 0 3 3 3 0 PH domain Laminin_EGF PF00053.24 CDW55661.1 - 1.2e-32 111.8 328.1 0.0012 19.0 17.4 18.1 4 3 14 18 18 18 14 Laminin EGF domain hEGF PF12661.7 CDW55661.1 - 6.1e-10 39.3 233.2 0.0053 17.3 1.8 21.3 18 2 2 20 20 20 14 Human growth factor-like EGF EGF_2 PF07974.13 CDW55661.1 - 0.00018 21.8 60.0 0.001 19.4 15.5 27.1 22 11 6 28 28 28 12 EGF-like domain Pkinase_Tyr PF07714.17 CDW55662.1 - 7e-97 323.8 0.0 9.3e-97 323.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW55662.1 - 3.5e-49 167.5 0.0 5.2e-49 167.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW55662.1 - 5.2e-22 77.7 0.0 1.1e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 CDW55662.1 - 3.1e-12 45.9 0.1 7.3e-12 44.7 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CDW55662.1 - 1.8e-09 37.3 0.0 4.4e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CDW55662.1 - 2.7e-05 23.8 0.0 6.9e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 CDW55662.1 - 0.0033 17.5 0.0 0.0077 16.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain MRP-S27 PF10037.9 CDW55663.1 - 2.1e-71 240.9 0.0 2.9e-71 240.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 Snf7 PF03357.21 CDW55664.1 - 9.4e-55 184.9 17.0 9.4e-55 184.9 17.0 1.4 1 1 0 1 1 1 1 Snf7 SYF2 PF08231.12 CDW55664.1 - 0.0014 19.0 6.2 0.0014 19.0 6.2 1.6 1 1 0 1 1 1 1 SYF2 splicing factor Ribosomal_60s PF00428.19 CDW55664.1 - 0.68 10.6 7.2 0.25 11.9 2.8 2.3 1 1 2 3 3 3 0 60s Acidic ribosomal protein V_ATPase_I PF01496.19 CDW55664.1 - 1.4 6.8 10.4 1.5 6.6 10.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lsr2 PF11774.8 CDW55664.1 - 2 8.6 8.8 0.31 11.2 0.7 2.4 1 1 0 2 2 2 0 Lsr2 Vps5 PF09325.10 CDW55665.1 - 9.6e-60 202.1 13.0 1.8e-59 201.2 13.0 1.4 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CDW55665.1 - 5.9e-20 71.3 0.3 4.3e-19 68.6 0.0 2.2 2 0 0 2 2 2 1 PX domain BAR_3_WASP_bdg PF10456.9 CDW55665.1 - 0.0003 20.3 6.4 0.0025 17.3 6.4 2.0 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein MPM1 PF17234.2 CDW55665.1 - 0.043 14.1 1.7 0.081 13.2 1.7 1.5 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 DUF1765 PF08578.10 CDW55665.1 - 0.091 13.2 0.3 0.31 11.5 0.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1765) AbiH PF14253.6 CDW55665.1 - 9.5 6.0 9.2 10 5.9 5.6 2.1 1 1 0 2 2 2 0 Bacteriophage abortive infection AbiH COBRA1 PF06209.13 CDW55666.1 - 4.3e-71 240.2 5.2 5.7e-71 239.8 5.2 1.1 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) CD36 PF01130.21 CDW55666.1 - 0.052 12.1 0.0 0.074 11.6 0.0 1.1 1 0 0 1 1 1 0 CD36 family Cas_Cas2CT1978 PF09707.10 CDW55666.1 - 0.081 13.0 0.1 5.3 7.2 0.0 2.8 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) Sulfotransfer_1 PF00685.27 CDW55667.1 - 7.9e-71 238.7 2.5 9.3e-71 238.4 2.5 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDW55667.1 - 3.3e-08 34.2 0.1 0.0065 16.9 0.1 2.3 2 0 0 2 2 2 2 Sulfotransferase family tRNA-synt_2 PF00152.20 CDW55668.1 - 5.8e-78 262.1 0.1 7.1e-78 261.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDW55668.1 - 1.5e-09 37.7 0.7 6.2e-09 35.7 0.6 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDW55668.1 - 0.00025 20.6 0.3 0.79 9.1 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Pkinase PF00069.25 CDW55669.1 - 7.4e-45 153.4 0.1 1.1e-44 152.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55669.1 - 7.4e-23 81.1 0.0 2.4e-22 79.4 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW55669.1 - 0.0013 17.5 2.0 0.0027 16.5 2.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 CDW55669.1 - 0.0051 15.8 0.1 0.0083 15.1 0.1 1.2 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 CDW55669.1 - 0.023 14.3 1.5 0.098 12.2 0.0 2.5 3 0 0 3 3 3 0 RIO1 family APH PF01636.23 CDW55669.1 - 0.064 13.2 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2828 PF11443.8 CDW55670.1 - 0.08 11.0 1.6 0.1 10.7 1.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3040 PF11239.8 CDW55670.1 - 0.1 12.9 0.1 23 5.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Coatomer_WDAD PF04053.14 CDW55672.1 - 1.9e-140 468.8 0.0 3.3e-139 464.8 0.0 2.1 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 CDW55672.1 - 2.7e-36 123.0 9.3 9.1e-09 35.8 0.1 7.8 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55672.1 - 0.00059 20.1 0.1 4.7 7.6 0.0 5.0 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CDW55672.1 - 0.0027 17.7 0.0 11 6.1 0.0 4.0 2 2 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 CDW55672.1 - 0.13 10.9 3.1 3.8 6.0 0.0 3.2 1 1 2 4 4 4 0 Nucleoporin Nup120/160 7TM_GPCR_Srw PF10324.9 CDW55673.1 - 8.1e-41 140.3 18.4 1e-40 140.0 18.4 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW55673.1 - 0.021 14.2 13.1 0.046 13.0 13.1 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF1195 PF06708.11 CDW55673.1 - 0.021 14.6 0.0 0.05 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1195) Neur_chan_LBD PF02931.23 CDW55674.1 - 5.4e-52 176.4 5.2 7.7e-52 175.9 5.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW55674.1 - 2.2e-17 63.9 3.5 3.1e-17 63.4 3.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region TMEM138 PF14935.6 CDW55675.1 - 2e-07 31.7 10.8 5.6e-07 30.2 10.8 1.9 1 1 0 1 1 1 1 Transmembrane protein 138 TPR_1 PF00515.28 CDW55676.1 - 2.7e-16 58.6 5.3 0.00093 18.9 0.0 6.1 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55676.1 - 1.8e-13 49.4 8.9 0.015 15.4 0.0 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55676.1 - 1.4e-11 43.6 10.0 0.081 13.2 0.0 6.0 7 0 0 7 7 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDW55676.1 - 4.7e-08 32.6 0.5 0.00041 20.0 0.0 4.2 3 1 1 4 4 4 1 TPR repeat TPR_12 PF13424.6 CDW55676.1 - 1.7e-07 31.4 2.7 0.23 11.8 0.1 4.6 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW55676.1 - 3.5e-07 30.8 2.3 0.002 18.7 1.6 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW55676.1 - 3.6e-05 24.2 0.1 1.7 9.7 0.0 4.0 2 1 2 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW55676.1 - 0.00011 22.6 0.4 1.8 9.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW55676.1 - 0.0009 19.5 5.0 0.12 12.8 0.1 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDW55676.1 - 0.0012 18.7 1.2 9.2 6.6 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW55676.1 - 0.047 13.9 12.2 0.096 12.9 0.5 4.0 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 CDW55676.1 - 0.051 13.7 0.0 2.5 8.3 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat CobT PF06213.12 CDW55676.1 - 0.11 11.9 15.5 0.17 11.3 15.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pur_ac_phosph_N PF16656.5 CDW55676.1 - 0.14 12.8 0.0 0.33 11.5 0.0 1.7 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain DUF4820 PF16091.5 CDW55676.1 - 0.34 10.2 5.5 0.58 9.5 5.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TFIIA PF03153.13 CDW55676.1 - 0.66 9.9 10.1 0.94 9.4 10.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DARPP-32 PF05395.12 CDW55676.1 - 1.1 9.5 14.5 1.7 8.8 14.5 1.2 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 Astro_capsid_p PF12226.8 CDW55676.1 - 1.5 7.9 13.9 2.3 7.3 13.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein D123 PF07065.14 CDW55676.1 - 1.9 7.5 12.1 2.8 7.0 12.1 1.2 1 0 0 1 1 1 0 D123 RXT2_N PF08595.11 CDW55676.1 - 6.4 6.8 13.8 11 6.0 13.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Ribo_biogen_C PF04034.13 CDW55678.1 - 2.8e-51 172.5 0.0 3.5e-51 172.2 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CDW55678.1 - 1.7e-09 37.3 0.3 1.7e-09 37.3 0.3 2.3 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI Chorion_2 PF03964.15 CDW55678.1 - 0.82 10.5 14.2 11 6.9 9.7 2.3 2 0 0 2 2 2 0 Chorion family 2 Ndc80_HEC PF03801.13 CDW55679.1 - 4.9e-15 55.5 0.0 1.8e-14 53.6 0.0 2.0 1 0 0 1 1 1 1 HEC/Ndc80p family Mac PF12464.8 CDW55679.1 - 0.011 15.9 0.7 0.17 12.2 0.1 2.7 2 0 0 2 2 2 0 Maltose acetyltransferase Band_7 PF01145.25 CDW55679.1 - 1.2 9.1 6.0 3.1 7.8 6.0 1.7 1 0 0 1 1 1 0 SPFH domain / Band 7 family Atg14 PF10186.9 CDW55679.1 - 3.5 6.6 38.4 3.4 6.7 23.9 3.1 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5082 PF16888.5 CDW55679.1 - 4.4 7.6 31.8 5.6 7.3 16.5 4.1 2 2 2 4 4 4 0 Domain of unknown function (DUF5082) ATP-synt PF00231.19 CDW55680.1 - 6.3e-78 262.3 0.3 7.1e-78 262.1 0.3 1.0 1 0 0 1 1 1 1 ATP synthase Ribosomal_L21e PF01157.18 CDW55681.1 - 9.2e-46 153.8 2.5 9.2e-46 153.8 2.5 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e OHA PF14418.6 CDW55681.1 - 0.066 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 OST-HTH Associated domain PVL_ORF50 PF07768.11 CDW55681.1 - 0.28 11.5 4.7 0.12 12.7 1.6 1.8 2 0 0 2 2 2 0 PVL ORF-50-like family Thioredoxin PF00085.20 CDW55682.1 - 2e-78 259.0 0.0 3.5e-25 88.0 0.0 4.2 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 CDW55682.1 - 6.4e-22 78.4 0.3 3.4e-09 36.9 0.3 4.5 2 1 2 4 4 4 4 Thioredoxin-like domain Calsequestrin PF01216.17 CDW55682.1 - 9.4e-09 34.8 0.1 6.9e-07 28.6 0.0 2.5 1 1 1 2 2 2 1 Calsequestrin Thioredoxin_2 PF13098.6 CDW55682.1 - 5.7e-08 33.2 1.7 0.1 13.1 0.0 4.8 3 3 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDW55682.1 - 3.1e-07 30.5 0.0 0.12 12.6 0.0 3.5 3 0 0 3 3 3 2 Thioredoxin-like OST3_OST6 PF04756.13 CDW55682.1 - 9.5e-06 25.2 0.0 0.079 12.3 0.0 3.6 4 0 0 4 4 4 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 CDW55682.1 - 0.00015 22.0 0.6 4.9 7.5 0.0 4.6 5 1 0 5 5 5 1 Thioredoxin-like Thioredoxin_4 PF13462.6 CDW55682.1 - 0.00037 20.7 1.4 0.14 12.3 0.0 3.6 3 0 0 3 3 3 1 Thioredoxin TraF PF13728.6 CDW55682.1 - 0.1 12.4 0.0 1.6 8.5 0.0 2.6 3 0 0 3 3 3 0 F plasmid transfer operon protein TTL PF03133.15 CDW55683.1 - 6.6e-83 278.2 0.0 9e-83 277.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 CDW55683.1 - 6.1e-07 29.0 0.0 0.00015 21.1 0.0 3.0 2 1 1 3 3 3 1 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 CDW55683.1 - 0.00021 20.6 0.0 0.014 14.7 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp EMP24_GP25L PF01105.24 CDW55684.1 - 4.1e-45 153.9 1.0 4.9e-45 153.7 1.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Snapin_Pallidin PF14712.6 CDW55684.1 - 0.002 18.5 0.2 0.0032 17.9 0.2 1.2 1 0 0 1 1 1 1 Snapin/Pallidin YcbB PF08664.10 CDW55684.1 - 0.042 13.9 0.1 0.068 13.2 0.1 1.3 1 0 0 1 1 1 0 YcbB domain BCDHK_Adom3 PF10436.9 CDW55685.1 - 7.9e-15 55.1 0.1 4.8e-14 52.5 0.1 1.9 1 1 1 2 2 2 2 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CDW55685.1 - 2e-09 37.9 0.0 3.1e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDW55685.1 - 0.024 14.4 0.0 0.038 13.8 0.0 1.2 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase C2 PF00168.30 CDW55686.1 - 1.6e-35 121.5 0.0 9.4e-21 74.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain FYVE_2 PF02318.16 CDW55686.1 - 1e-17 64.4 7.7 2.1e-17 63.4 7.7 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger DUF5436 PF17504.2 CDW55688.1 - 0.072 13.4 0.3 0.16 12.3 0.2 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5436) Ribosomal_S3_C PF00189.20 CDW55689.1 - 2e-22 79.5 0.5 3.7e-22 78.6 0.3 1.5 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CDW55689.1 - 2.1e-08 33.9 0.1 3.3e-08 33.2 0.1 1.3 1 0 0 1 1 1 1 KH domain Glycos_transf_1 PF00534.20 CDW55690.1 - 3.8e-28 98.2 0.0 7.4e-26 90.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDW55690.1 - 1e-14 55.1 0.0 2.1e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDW55690.1 - 3.3e-07 30.4 0.0 6.3e-07 29.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDW55690.1 - 0.0005 20.4 0.0 0.00093 19.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 CDW55690.1 - 1.4 8.9 4.5 75 3.3 0.1 3.7 3 1 0 4 4 4 0 ALG11 mannosyltransferase N-terminus ER_lumen_recept PF00810.18 CDW55691.1 - 5e-56 189.6 11.7 7.6e-56 189.0 11.7 1.3 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 CDW55691.1 - 0.017 14.9 3.4 1.6 8.5 0.6 2.8 2 0 0 2 2 2 0 PQ loop repeat SLAC1 PF03595.17 CDW55691.1 - 0.082 12.2 10.4 0.017 14.4 6.9 1.5 1 1 1 2 2 2 0 Voltage-dependent anion channel PMBR PF09373.10 CDW55691.1 - 5.7 7.3 8.6 8.8 6.7 0.8 3.4 3 0 0 3 3 3 0 Pseudomurein-binding repeat ENTH PF01417.20 CDW55692.1 - 1.6e-47 160.6 0.3 1.6e-47 160.6 0.3 1.8 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.16 CDW55692.1 - 3.7e-06 26.1 0.1 6.2e-06 25.4 0.1 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 CDW55692.1 - 0.00022 21.1 0.2 0.00048 20.0 0.2 1.6 1 0 0 1 1 1 1 VHS domain DUF4795 PF16043.5 CDW55692.1 - 0.0032 17.1 0.5 0.0075 15.9 0.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) UIM PF02809.20 CDW55692.1 - 0.069 13.1 9.8 0.76 9.8 3.5 2.8 2 0 0 2 2 2 0 Ubiquitin interaction motif UCR_UQCRX_QCR9 PF05365.12 CDW55692.1 - 0.1 12.6 0.3 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like TGF_beta_GS PF08515.12 CDW55692.1 - 0.11 12.0 0.0 0.49 9.9 0.0 2.1 1 0 0 1 1 1 0 Transforming growth factor beta type I GS-motif Ran_BP1 PF00638.18 CDW55694.1 - 4.3e-71 236.9 6.3 4.9e-37 126.9 0.7 2.3 2 0 0 2 2 2 2 RanBP1 domain WH1 PF00568.23 CDW55694.1 - 0.0021 17.9 0.6 2.3 8.2 0.1 2.7 2 1 0 2 2 2 2 WH1 domain TPR_14 PF13428.6 CDW55695.1 - 0.0012 19.4 0.0 6.9 7.8 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW55695.1 - 0.0018 18.8 0.0 3.9 8.0 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55695.1 - 0.0047 16.9 4.7 97 3.5 0.0 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDW55695.1 - 0.011 15.4 0.6 0.078 12.7 0.0 2.9 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 CDW55695.1 - 0.011 16.0 4.3 1.1 9.8 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Rio2_N PF09202.11 CDW55695.1 - 0.02 15.1 0.0 0.14 12.4 0.0 2.3 2 0 0 2 2 2 0 Rio2, N-terminal HipN PF18253.1 CDW55695.1 - 0.065 12.9 0.1 0.27 11.0 0.1 2.1 2 0 0 2 2 2 0 Hsp70-interacting protein N N-terminal domain TPR_1 PF00515.28 CDW55695.1 - 5.7 6.9 15.4 23 5.0 0.1 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat MCM PF00493.23 CDW55696.1 - 3.1e-101 337.1 0.1 4.5e-101 336.6 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDW55696.1 - 2.9e-36 124.1 0.3 5.7e-36 123.1 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDW55696.1 - 5.4e-25 87.6 1.3 1.2e-24 86.5 1.3 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 CDW55696.1 - 2.1e-17 63.3 0.6 6.5e-17 61.7 0.1 2.1 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain Mg_chelatase PF01078.21 CDW55696.1 - 7.7e-08 32.0 0.0 3e-07 30.0 0.0 1.8 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDW55696.1 - 9.6e-05 22.2 0.0 0.00027 20.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW55696.1 - 0.001 19.1 0.0 0.0027 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDW55696.1 - 0.0021 17.8 0.0 0.0065 16.2 0.0 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain TIP49_C PF17856.1 CDW55696.1 - 0.075 13.2 0.1 0.25 11.5 0.1 1.9 1 0 0 1 1 1 0 TIP49 AAA-lid domain Mg_chelatase_C PF13335.6 CDW55696.1 - 0.18 12.5 0.8 0.59 10.8 0.8 1.9 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal Motile_Sperm PF00635.26 CDW55697.1 - 7e-07 29.1 0.0 8.5e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain HLH PF00010.26 CDW55698.1 - 6.9e-16 57.9 0.6 1.3e-15 57.1 0.6 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 CDW55698.1 - 0.022 14.6 0.0 0.057 13.3 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain NLPC_P60 PF00877.19 CDW55698.1 - 0.024 14.7 0.0 0.047 13.7 0.0 1.5 1 0 0 1 1 1 0 NlpC/P60 family Peptidase_M17 PF00883.21 CDW55699.1 - 9.9e-103 343.7 0.0 1.3e-102 343.3 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDW55699.1 - 0.092 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain eIF-5a PF01287.20 CDW55700.1 - 1.4e-23 82.8 1.0 1.9e-23 82.3 1.0 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 CDW55700.1 - 0.0068 16.4 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Ribosomal_S26e PF01283.19 CDW55701.1 - 1.9e-52 176.2 6.4 2.3e-52 176.0 6.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e CRAL_TRIO PF00650.20 CDW55702.1 - 8e-22 77.7 0.0 1.2e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDW55702.1 - 0.0077 16.4 0.0 0.019 15.1 0.0 1.6 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain LIM PF00412.22 CDW55703.1 - 1.7e-16 60.1 40.7 5.3e-07 29.8 6.4 4.0 2 1 0 3 3 3 3 LIM domain E6 PF00518.17 CDW55703.1 - 0.28 11.6 23.7 0.93 10.0 9.8 3.7 1 1 1 2 2 2 0 Early Protein (E6) zf-CHY PF05495.12 CDW55703.1 - 6.2 7.4 38.3 1.6 9.2 3.2 3.7 1 1 3 4 4 4 0 CHY zinc finger Treslin_N PF15292.6 CDW55705.1 - 0.0013 17.2 0.1 0.0016 16.9 0.1 1.1 1 0 0 1 1 1 1 Treslin N-terminus RNA_pol_Rpb5_C PF01191.19 CDW55706.1 - 7e-34 115.5 1.7 7.7e-34 115.4 0.6 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 CDW55706.1 - 2e-30 105.2 0.1 3.5e-30 104.4 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain DUF4817 PF16087.5 CDW55706.1 - 0.0072 16.1 0.2 0.07 13.0 0.0 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain (DUF4817) Pkinase PF00069.25 CDW55707.1 - 2.2e-53 181.3 0.0 2.8e-53 181.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55707.1 - 2.1e-38 132.1 0.0 2.7e-38 131.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW55707.1 - 5e-05 22.8 0.0 6.8e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 CDW55707.1 - 0.0002 20.5 0.0 0.00036 19.7 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 CDW55707.1 - 0.0056 15.7 0.1 0.01 14.8 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain EcsC PF12787.7 CDW55707.1 - 0.094 12.4 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 EcsC protein family Glyco_transf_10 PF00852.19 CDW55708.1 - 2.9e-64 216.0 3.2 4.1e-64 215.5 3.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW55708.1 - 5.4e-17 62.2 0.0 2.1e-16 60.3 0.0 2.0 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Methyltransf_23 PF13489.6 CDW55709.1 - 5.5e-15 55.6 0.0 7.1e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW55709.1 - 2.3e-14 53.9 0.0 5e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW55709.1 - 8.3e-14 52.0 0.0 4.7e-13 49.6 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW55709.1 - 7.3e-12 45.9 0.0 1.6e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW55709.1 - 1.3e-08 34.8 0.0 2.1e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDW55709.1 - 2.4e-06 27.1 0.0 4.4e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TehB PF03848.14 CDW55709.1 - 0.0041 16.6 0.0 0.0066 15.9 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 CDW55709.1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_24 PF13578.6 CDW55709.1 - 0.14 13.2 0.0 0.36 11.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Glyco_transf_10 PF00852.19 CDW55710.1 - 2.7e-51 173.8 0.6 4e-51 173.2 0.6 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW55710.1 - 6.5e-20 71.6 0.3 1.8e-19 70.2 0.1 1.8 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Hormone_3 PF00159.18 CDW55710.1 - 0.13 12.4 0.1 4.5 7.4 0.0 2.7 2 0 0 2 2 2 0 Pancreatic hormone peptide IF4E PF01652.18 CDW55711.1 - 2.8e-33 115.0 1.6 6.1e-33 113.9 1.6 1.5 1 1 0 1 1 1 1 Eukaryotic initiation factor 4E IF4E PF01652.18 CDW55712.1 - 2.8e-40 137.7 0.0 3.7e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Glyco_transf_10 PF00852.19 CDW55713.1 - 4.2e-47 160.1 2.5 6.8e-47 159.5 2.5 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW55713.1 - 1.9e-22 79.8 0.0 3.7e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 CDW55714.1 - 3.4e-51 173.4 5.1 4.7e-51 173.0 5.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW55714.1 - 1.1e-23 83.8 0.3 5e-23 81.7 0.0 2.1 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 CDW55715.1 - 7e-54 182.2 2.2 1.1e-53 181.5 2.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW55715.1 - 2.6e-22 79.4 0.1 5.3e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Fucosyltransferase, N-terminal TMEM252 PF15664.5 CDW55715.1 - 0.067 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 252 family Sensor_TM1 PF13755.6 CDW55715.1 - 0.19 11.5 0.5 0.34 10.7 0.5 1.3 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain WD40 PF00400.32 CDW55716.1 - 2.5e-34 116.7 18.5 2.8e-07 31.1 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55716.1 - 5.5e-18 65.1 0.1 8.8e-05 22.7 0.0 6.4 4 2 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW55716.1 - 1.1e-05 25.0 0.4 0.0039 16.6 0.0 3.3 2 2 2 4 4 4 1 WD40-like domain Ge1_WD40 PF16529.5 CDW55716.1 - 4.7e-05 22.5 0.0 0.022 13.7 0.0 3.2 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CDW55716.1 - 0.00015 21.7 0.0 0.0028 17.6 0.0 2.8 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 CDW55716.1 - 0.00018 20.9 0.0 0.011 15.1 0.0 2.9 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 CDW55716.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.5 1 1 0 1 1 1 0 PQQ-like domain Gmad1 PF10647.9 CDW55716.1 - 0.15 11.8 0.0 0.9 9.2 0.0 1.9 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain DUF4394 PF14339.6 CDW55716.1 - 0.17 11.2 0.0 5.8 6.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4394) Glyco_transf_10 PF00852.19 CDW55718.1 - 4e-52 176.5 0.6 5.7e-52 176.0 0.6 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW55718.1 - 1.2e-20 74.0 1.3 2.4e-20 73.1 0.1 1.9 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Hormone_3 PF00159.18 CDW55718.1 - 0.079 13.1 0.2 4.4 7.5 0.0 2.8 2 0 0 2 2 2 0 Pancreatic hormone peptide TPR_17 PF13431.6 CDW55719.1 - 4.2e-06 26.8 0.0 0.0023 18.2 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat Linocin_M18 PF04454.12 CDW55719.1 - 0.0008 18.8 0.1 0.0012 18.2 0.1 1.2 1 0 0 1 1 1 1 Encapsulating protein for peroxidase TPR_2 PF07719.17 CDW55719.1 - 0.002 18.1 0.8 4.5 7.6 0.5 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Tap-RNA_bind PF09162.10 CDW55719.1 - 0.041 13.7 0.0 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Tap, RNA-binding TPR_11 PF13414.6 CDW55719.1 - 0.052 13.2 0.1 0.16 11.7 0.1 1.8 1 1 1 2 2 2 0 TPR repeat TPR_12 PF13424.6 CDW55719.1 - 0.077 13.3 1.6 0.23 11.8 0.9 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDW55719.1 - 0.12 13.2 3.8 0.37 11.7 0.2 3.0 3 2 1 4 4 4 0 Tetratricopeptide repeat ChAPs PF09295.10 CDW55719.1 - 0.14 11.1 0.1 0.18 10.8 0.1 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) Bystin PF05291.11 CDW55720.1 - 1.3e-113 379.2 0.1 2e-113 378.5 0.1 1.3 1 0 0 1 1 1 1 Bystin zf-RING_2 PF13639.6 CDW55721.1 - 5e-07 29.9 18.6 5e-07 29.9 18.6 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDW55721.1 - 9.9e-07 28.5 14.0 1.8e-06 27.7 14.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW55721.1 - 1.2e-05 25.0 18.7 2e-05 24.3 18.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDW55721.1 - 6.4e-05 23.2 12.8 0.00013 22.2 12.8 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CDW55721.1 - 8.4e-05 22.3 18.3 0.00014 21.6 18.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW55721.1 - 0.0041 17.0 13.5 0.0077 16.1 13.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CDW55721.1 - 0.25 11.4 15.2 0.54 10.3 15.2 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 CDW55721.1 - 2.8 8.0 19.4 48 4.0 19.3 2.3 1 1 1 2 2 2 0 zinc-RING finger domain Myosin_head PF00063.21 CDW55722.1 - 2.1e-300 997.9 3.7 2.1e-300 997.9 3.7 3.1 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 CDW55722.1 - 5.2e-296 984.8 282.4 7.1e-296 984.4 282.4 1.2 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 CDW55722.1 - 2.4e-13 49.7 0.0 7.5e-13 48.1 0.0 2.0 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain IQ PF00612.27 CDW55722.1 - 0.00085 18.9 0.2 0.0038 16.9 0.0 2.3 2 0 0 2 2 2 1 IQ calmodulin-binding motif YgbB PF02542.16 CDW55722.1 - 7.3 6.9 6.8 3.6 7.9 1.5 3.1 2 0 0 2 2 2 0 YgbB family SMI1_KNR4 PF09346.10 CDW55723.1 - 0.079 13.3 0.0 0.21 12.0 0.0 1.6 1 1 1 2 2 2 0 SMI1 / KNR4 family (SUKH-1) Aminotran_1_2 PF00155.21 CDW55724.1 - 9.3e-72 242.2 0.0 2.6e-71 240.7 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II T-box PF00907.22 CDW55725.1 - 5.2e-71 238.7 0.0 6.2e-71 238.5 0.0 1.1 1 0 0 1 1 1 1 T-box Pep_M12B_propep PF01562.19 CDW55725.1 - 0.073 13.3 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Reprolysin family propeptide Exo_endo_phos PF03372.23 CDW55726.1 - 0.061 12.8 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family IRK_C PF17655.1 CDW55727.1 - 8.2e-47 159.0 0.2 9.9e-45 152.3 0.2 2.2 1 1 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 CDW55727.1 - 2.2e-43 147.4 1.8 3.5e-43 146.8 1.8 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 CDW55727.1 - 0.0014 18.5 1.3 0.0024 17.8 1.3 1.4 1 0 0 1 1 1 1 Ion channel Ank_2 PF12796.7 CDW55728.1 - 7.1e-16 58.6 1.4 2.2e-10 41.0 0.4 3.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW55728.1 - 1.3e-13 51.2 3.0 6.4e-06 26.6 0.2 5.7 4 2 3 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW55728.1 - 2e-12 47.1 1.4 0.00014 22.1 0.5 5.7 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 CDW55728.1 - 2.7e-11 43.4 1.8 0.00045 20.6 0.0 5.3 5 1 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 CDW55728.1 - 5.5e-11 41.7 0.5 0.036 14.6 0.2 6.4 6 0 0 6 6 6 3 Ankyrin repeat SHR-BD PF06650.12 CDW55729.1 - 4e-34 118.2 0.0 4.5e-33 114.8 0.0 2.5 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 CDW55729.1 - 7e-18 65.0 5.2 4.7e-14 52.6 0.0 4.0 2 2 2 4 4 4 4 Vacuolar-sorting-associated 13 protein C-terminal Peptidase_C33 PF05412.12 CDW55729.1 - 0.08 13.0 0.0 45 4.1 0.0 3.5 3 0 0 3 3 3 0 Equine arterivirus Nsp2-type cysteine proteinase Chorein_N PF12624.7 CDW55731.1 - 7.2e-16 58.3 0.1 2.2e-15 56.8 0.1 1.8 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13 PF16908.5 CDW55731.1 - 4.2e-15 56.2 0.1 8.4e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal DUF2683 PF10884.8 CDW55731.1 - 0.052 13.8 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) Cyclin_N PF00134.23 CDW55732.1 - 7.3e-06 25.7 10.1 1.3e-05 24.9 4.9 3.1 3 1 0 3 3 3 1 Cyclin, N-terminal domain LEDGF PF11467.8 CDW55732.1 - 0.73 9.5 4.0 1.8 8.2 0.5 2.8 3 0 0 3 3 3 0 Lens epithelium-derived growth factor (LEDGF) Guanylate_kin PF00625.21 CDW55734.1 - 3.8e-39 134.2 0.1 5.6e-38 130.4 0.1 2.2 1 1 0 1 1 1 1 Guanylate kinase ImpA_N PF06812.12 CDW55734.1 - 0.053 13.6 0.0 0.83 9.8 0.0 2.5 2 0 0 2 2 2 0 ImpA, N-terminal, type VI secretion system SH3_1 PF00018.28 CDW55734.1 - 0.074 12.7 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 SH3 domain Ribul_P_3_epim PF00834.19 CDW55735.1 - 3.9e-63 212.4 0.0 4.7e-63 212.2 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family TMP-TENI PF02581.17 CDW55735.1 - 0.00019 20.8 0.2 0.00035 20.0 0.0 1.4 2 0 0 2 2 2 1 Thiamine monophosphate synthase QRPTase_C PF01729.19 CDW55735.1 - 0.043 13.6 0.0 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Aldolase PF01081.19 CDW55735.1 - 0.095 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 KDPG and KHG aldolase TPR_1 PF00515.28 CDW55736.1 - 1.5e-10 40.5 4.4 0.13 12.1 0.1 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 CDW55736.1 - 7e-09 35.1 7.5 0.44 10.8 0.1 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55736.1 - 3.2e-07 30.0 4.0 0.65 10.4 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW55736.1 - 6.2e-07 29.7 4.4 1.3 10.0 0.0 5.5 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW55736.1 - 3.5e-05 23.4 1.7 0.034 13.8 0.0 3.8 4 0 0 4 4 4 2 TPR repeat TPR_12 PF13424.6 CDW55736.1 - 3.8e-05 23.9 2.9 0.033 14.5 0.0 3.8 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW55736.1 - 0.0001 22.7 1.9 4.2 8.0 0.0 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDW55736.1 - 0.00032 20.5 0.9 6 7.1 0.0 4.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW55736.1 - 0.00068 19.8 0.1 0.063 13.7 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat DUF627 PF04781.12 CDW55736.1 - 0.027 14.5 0.7 6.9 6.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF627) TPR_16 PF13432.6 CDW55736.1 - 0.031 14.9 0.6 13 6.5 0.2 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDW55736.1 - 0.049 14.3 2.0 5.8 7.8 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF3361 PF11841.8 CDW55737.1 - 1.3e-29 103.2 0.2 2.1e-29 102.4 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) ELMO_CED12 PF04727.13 CDW55737.1 - 5.4e-25 88.5 0.0 9.6e-25 87.7 0.0 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 CDW55737.1 - 3.6e-10 40.5 0.0 1e-07 32.6 0.0 2.5 1 1 1 2 2 2 2 Pleckstrin homology domain Sin3a_C PF16879.5 CDW55738.1 - 1.2e-32 113.8 2.1 8.5e-32 111.0 0.1 2.7 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 CDW55738.1 - 2.7e-22 78.7 0.0 1.3e-21 76.4 0.0 2.3 1 1 1 2 2 2 1 Sin3 family co-repressor PAH PF02671.21 CDW55738.1 - 9.6e-12 44.8 6.7 3.8e-10 39.8 0.5 3.1 3 0 0 3 3 3 2 Paired amphipathic helix repeat SSP160 PF06933.11 CDW55738.1 - 0.24 9.5 5.6 0.39 8.9 5.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 CDW55738.1 - 0.24 9.3 2.6 0.4 8.6 2.6 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 CDW55738.1 - 0.85 9.6 8.1 2.1 8.3 8.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ion_trans_2 PF07885.16 CDW55740.1 - 9e-27 92.9 13.7 2.8e-19 68.8 1.2 2.5 2 0 0 2 2 2 2 Ion channel fn3 PF00041.21 CDW55740.1 - 9.6e-08 32.3 0.3 4.7e-07 30.1 0.2 2.0 2 0 0 2 2 2 1 Fibronectin type III domain Ion_trans PF00520.31 CDW55740.1 - 1.5e-05 24.4 1.0 0.00017 20.9 0.0 2.3 2 0 0 2 2 2 1 Ion transport protein Lig_chan PF00060.26 CDW55740.1 - 0.0024 17.7 0.0 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 Ligand-gated ion channel IRK PF01007.20 CDW55740.1 - 0.15 11.9 4.8 0.27 11.0 0.1 2.4 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain TctB PF07331.11 CDW55740.1 - 3.2 8.0 7.7 13 6.1 1.2 2.3 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Methyltransf_1N PF02870.15 CDW55742.1 - 0.13 13.1 0.1 0.7 10.7 0.1 2.3 2 0 0 2 2 2 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain MBOAT PF03062.19 CDW55743.1 - 1.3e-31 110.3 2.6 1.8e-31 109.8 2.6 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Methyltransf_25 PF13649.6 CDW55744.1 - 7.6e-07 29.7 0.0 2.1e-06 28.3 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 CDW55744.1 - 5.2e-06 26.1 0.0 8e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 CDW55744.1 - 3.1e-05 23.1 0.0 4.9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 CDW55744.1 - 0.00012 21.7 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CDW55744.1 - 0.00045 20.8 0.0 0.0011 19.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PRMT5_C PF17286.2 CDW55744.1 - 0.0016 18.3 0.3 0.0048 16.8 0.1 1.8 2 0 0 2 2 2 1 PRMT5 oligomerisation domain CMAS PF02353.20 CDW55744.1 - 0.003 16.9 0.0 0.0045 16.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 CDW55744.1 - 0.003 17.4 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_23 PF13489.6 CDW55744.1 - 0.0038 17.1 0.0 0.0095 15.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW55744.1 - 0.0081 16.1 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDW55744.1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DREV PF05219.12 CDW55744.1 - 0.09 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase ISP3_C PF18045.1 CDW55744.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 ISP3 C-terminal ISP1_C PF18161.1 CDW55744.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 ISP1 C-terminal Methyltransf_31 PF13847.6 CDW55744.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 CDW55744.1 - 0.14 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CDW55744.1 - 0.22 11.3 0.0 0.38 10.5 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase HMG_box PF00505.19 CDW55745.1 - 1.7e-16 60.3 0.1 3.1e-16 59.6 0.1 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW55745.1 - 7.7e-11 42.4 0.3 1.4e-10 41.6 0.3 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 CDW55745.1 - 0.025 15.1 0.0 0.048 14.2 0.0 1.4 1 0 0 1 1 1 0 YABBY protein DUF2486 PF10667.9 CDW55745.1 - 0.029 14.6 0.1 0.25 11.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2486) WD40 PF00400.32 CDW55746.1 - 2.7e-23 81.8 11.4 9.2e-05 23.2 0.3 5.8 5 0 0 5 5 5 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 CDW55746.1 - 3.8e-23 81.5 1.2 1.4e-22 79.7 0.9 2.0 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ATE_C PF04377.15 CDW55748.1 - 3.8e-47 160.3 1.0 3.8e-47 160.3 1.0 1.7 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 CDW55748.1 - 1.9e-25 89.1 4.8 1.9e-25 89.1 4.8 1.9 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, N terminus YL1 PF05764.13 CDW55749.1 - 3.3e-24 86.3 13.3 4.8e-24 85.8 13.3 1.2 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.11 CDW55749.1 - 2.2e-10 40.1 0.1 5.1e-10 38.9 0.1 1.7 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain EppA_BapA PF07268.11 CDW55750.1 - 0.19 11.6 0.0 0.29 11.1 0.0 1.2 1 0 0 1 1 1 0 Exported protein precursor (EppA/BapA) Acyl-CoA_dh_1 PF00441.24 CDW55751.1 - 5.9e-50 169.4 1.3 9.5e-50 168.7 1.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CDW55751.1 - 8.3e-26 90.0 0.0 1.3e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CDW55751.1 - 8.7e-23 81.1 0.0 2.4e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CDW55751.1 - 1.1e-20 74.2 0.0 1.8e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Sec63 PF02889.16 CDW55752.1 - 2.8e-162 537.9 6.1 8.1e-86 287.3 0.5 2.4 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CDW55752.1 - 2.5e-45 154.4 0.0 7.9e-26 90.9 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 CDW55752.1 - 9.1e-39 132.1 1.1 3.5e-38 130.2 1.1 2.1 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 CDW55752.1 - 3.4e-21 76.0 0.0 1e-13 51.6 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDW55752.1 - 3e-10 40.4 0.2 2.2e-06 28.0 0.0 3.6 3 1 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDW55752.1 - 0.015 15.6 7.8 0.017 15.4 0.0 4.7 7 0 0 7 7 7 0 AAA domain T2SSE PF00437.20 CDW55752.1 - 0.073 12.1 0.0 2.4 7.2 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_11 PF13086.6 CDW55752.1 - 0.38 10.5 2.5 0.85 9.4 0.0 2.6 2 1 0 2 2 2 0 AAA domain Topoisom_bac PF01131.20 CDW55753.1 - 2.4e-102 343.0 0.0 3.1e-102 342.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 CDW55753.1 - 1.6e-18 66.8 0.0 3.5e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 Toprim domain zf-RING_12 PF17976.1 CDW55753.1 - 0.056 13.7 4.7 0.87 9.9 0.1 3.3 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C2H2_10 PF16588.5 CDW55753.1 - 0.068 12.9 0.3 0.068 12.9 0.3 3.1 5 0 0 5 5 5 0 C2H2 zinc-finger CSN8_PSD8_EIF3K PF10075.9 CDW55754.1 - 1.3e-22 80.4 0.3 1.7e-22 79.9 0.3 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SCAB_CC PF16712.5 CDW55754.1 - 0.06 13.2 0.1 11 5.9 0.0 2.1 1 1 0 2 2 2 0 Coiled-coil regions of plant-specific actin-binding protein PCI PF01399.27 CDW55754.1 - 0.08 13.5 0.1 0.4 11.2 0.1 2.0 1 1 1 2 2 2 0 PCI domain Asparaginase_2 PF01112.18 CDW55755.1 - 2.7e-85 286.1 0.0 3e-85 285.9 0.0 1.0 1 0 0 1 1 1 1 Asparaginase DUF2532 PF10811.8 CDW55755.1 - 0.14 12.2 0.2 0.23 11.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2532) Pkinase PF00069.25 CDW55756.1 - 1.8e-68 230.8 0.0 1.3e-53 182.1 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain CaMKII_AD PF08332.10 CDW55756.1 - 1.8e-46 157.4 0.0 4.1e-46 156.3 0.0 1.6 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain Pkinase_Tyr PF07714.17 CDW55756.1 - 7.7e-27 94.2 0.0 1.5e-25 89.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase DUF4440 PF14534.6 CDW55756.1 - 2e-06 28.2 0.0 3.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 CDW55756.1 - 4.9e-05 23.6 0.0 0.0001 22.5 0.0 1.5 1 0 0 1 1 1 1 SnoaL-like domain Kdo PF06293.14 CDW55756.1 - 0.00092 18.6 0.1 0.0041 16.5 0.0 1.8 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW55756.1 - 0.014 15.3 0.0 3.2 7.6 0.0 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW55756.1 - 0.02 13.7 0.0 0.033 13.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PAP2_C PF14360.6 CDW55757.1 - 1.7e-14 54.1 4.0 1.7e-14 54.1 4.0 3.1 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2_3 PF14378.6 CDW55757.1 - 0.065 12.9 11.3 0.13 11.9 1.5 2.2 2 0 0 2 2 2 0 PAP2 superfamily PAP2 PF01569.21 CDW55757.1 - 1.9 8.2 10.4 0.082 12.7 1.3 2.2 2 0 0 2 2 2 0 PAP2 superfamily DNA_ligase_A_C PF04679.15 CDW55758.1 - 1.1e-16 61.3 0.0 2.1e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.5 CDW55758.1 - 2e-05 24.9 0.1 9.4e-05 22.8 0.0 2.0 1 1 1 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CDW55758.1 - 0.00015 22.1 0.0 0.00033 21.0 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.8 CDW55758.1 - 0.028 14.6 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 DNA ligase IV DNA_ligase_A_M PF01068.21 CDW55759.1 - 2e-37 128.9 0.0 2.9e-37 128.3 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 CDW55759.1 - 1.4e-10 41.7 0.0 2.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 CDW55759.1 - 0.00018 21.4 0.2 0.0018 18.1 0.2 2.2 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_N PF04675.14 CDW55759.1 - 0.00033 21.0 0.1 0.00066 20.1 0.1 1.5 1 0 0 1 1 1 1 DNA ligase N terminus Pkinase PF00069.25 CDW55760.1 - 3.3e-60 203.7 0.0 5.4e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55760.1 - 1.5e-30 106.3 0.0 2.2e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW55760.1 - 0.091 12.1 0.0 0.83 8.9 0.0 2.0 1 1 0 2 2 2 0 Kinase-like VF530 PF09905.9 CDW55760.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 DNA-binding protein VF530 PUB PF09409.10 CDW55761.1 - 7.5e-22 77.1 0.1 1.4e-21 76.2 0.1 1.5 1 0 0 1 1 1 1 PUB domain 7TM_GPCR_Srw PF10324.9 CDW55762.1 - 2.9e-38 132.0 20.3 3.4e-38 131.7 20.3 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW55762.1 - 0.00026 20.4 18.2 0.0004 19.8 18.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TMEM154 PF15102.6 CDW55762.1 - 0.11 12.3 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF3377 PF11857.8 CDW55762.1 - 0.41 10.6 2.4 1.5 8.8 2.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Pkinase PF00069.25 CDW55763.1 - 1.5e-53 181.9 0.0 9.4e-53 179.3 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55763.1 - 2.6e-30 105.6 0.1 2.1e-29 102.6 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW55763.1 - 5.1e-05 22.7 0.0 7.3e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDW55763.1 - 0.0017 18.0 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 CDW55763.1 - 0.0023 17.9 0.0 0.017 15.1 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family AAA PF00004.29 CDW55764.1 - 2.2e-28 99.3 0.2 2.3e-27 96.0 0.2 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW55764.1 - 5.1e-10 39.0 0.2 1e-09 38.1 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDW55764.1 - 7.5e-07 29.7 0.0 1.6e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 CDW55764.1 - 0.00028 20.9 0.2 0.0011 19.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDW55764.1 - 0.00088 19.6 0.1 0.0034 17.7 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 CDW55764.1 - 0.0011 19.2 0.0 0.0019 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDW55764.1 - 0.0013 17.9 0.0 0.0093 15.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CDW55764.1 - 0.0016 18.2 0.0 0.0034 17.1 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 CDW55764.1 - 0.0036 17.5 0.0 0.007 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CDW55764.1 - 0.0053 16.6 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDW55764.1 - 0.006 16.3 0.3 0.019 14.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 CDW55764.1 - 0.0085 15.6 0.2 0.76 9.2 0.0 2.4 1 1 0 2 2 2 1 PhoH-like protein TsaE PF02367.17 CDW55764.1 - 0.0086 16.1 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 CDW55764.1 - 0.012 15.5 0.2 0.029 14.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDW55764.1 - 0.013 15.9 0.0 0.029 14.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CDW55764.1 - 0.013 15.0 0.0 0.026 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CDW55764.1 - 0.014 15.9 0.0 0.028 15.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDW55764.1 - 0.025 14.0 0.1 0.046 13.1 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 CDW55764.1 - 0.03 14.0 0.1 0.079 12.6 0.1 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_25 PF13481.6 CDW55764.1 - 0.035 13.7 0.0 0.075 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW55764.1 - 0.038 13.7 0.0 0.13 12.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain ATPase PF06745.13 CDW55764.1 - 0.044 13.1 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 KaiC TIP49 PF06068.13 CDW55764.1 - 0.054 12.7 1.4 0.076 12.2 0.0 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_30 PF13604.6 CDW55764.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDW55764.1 - 0.057 13.8 0.1 0.14 12.5 0.1 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDW55764.1 - 0.057 13.9 0.1 0.18 12.3 0.0 1.9 2 1 0 2 2 2 0 ABC transporter Fib_alpha PF08702.10 CDW55764.1 - 0.058 13.6 0.7 0.18 12.0 0.7 1.8 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Zeta_toxin PF06414.12 CDW55764.1 - 0.1 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 CDW55764.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Parvo_NS1 PF01057.17 CDW55764.1 - 0.19 10.8 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CRAL_TRIO_2 PF13716.6 CDW55765.1 - 2.9e-34 118.2 2.1 3.4e-34 117.9 0.9 1.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 CDW55765.1 - 1.7e-32 112.4 0.0 3e-32 111.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO PF00650.20 CDW55765.1 - 2e-06 27.6 0.5 2.9e-05 23.9 0.5 2.3 1 1 0 1 1 1 1 CRAL/TRIO domain COPI_C PF06957.11 CDW55766.1 - 1.3e-154 514.8 0.0 1.7e-154 514.4 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 CDW55766.1 - 4.4e-123 411.6 0.0 7.1e-123 410.9 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 CDW55766.1 - 3.6e-37 125.7 20.6 1.1e-06 29.3 0.0 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55766.1 - 4.5e-09 36.5 2.1 1.6e-05 25.1 0.0 4.9 3 2 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_14 PF13428.6 CDW55766.1 - 0.012 16.4 0.2 9.3 7.4 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Nup160 PF11715.8 CDW55766.1 - 0.23 10.1 4.7 2.7 6.5 0.5 3.6 1 1 3 4 4 4 0 Nucleoporin Nup120/160 His_Phos_1 PF00300.22 CDW55767.1 - 1.4e-11 44.5 0.0 7.7e-11 42.0 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Motile_Sperm PF00635.26 CDW55768.1 - 5.1e-14 52.0 0.1 7.1e-14 51.6 0.1 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CAP_N PF01213.19 CDW55768.1 - 0.26 10.7 6.7 0.31 10.5 6.7 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal I-set PF07679.16 CDW55769.1 - 0 2911.9 66.0 3.1e-21 75.2 0.1 59.2 59 0 0 59 59 59 59 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW55769.1 - 0 1895.6 43.2 1.4e-19 70.5 0.3 58.5 58 0 0 58 58 58 58 Immunoglobulin domain Ig_2 PF13895.6 CDW55769.1 - 0 1130.8 73.6 6.4e-13 48.8 0.4 57.9 58 0 0 58 58 58 47 Immunoglobulin domain ig PF00047.25 CDW55769.1 - 0 1004.4 88.5 1.2e-13 51.0 1.2 55.8 56 2 0 56 56 55 40 Immunoglobulin domain V-set PF07686.17 CDW55769.1 - 6e-133 435.1 110.2 0.00033 20.8 0.2 65.5 54 24 0 54 54 53 29 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW55769.1 - 4.8e-83 273.3 36.0 0.0049 16.9 0.4 42.7 45 0 0 45 45 44 16 CD80-like C2-set immunoglobulin domain BiPBP_C PF06832.12 CDW55769.1 - 5.6e-46 154.5 1.3 1.2 9.2 0.1 35.3 46 1 0 46 46 37 5 Penicillin-Binding Protein C-terminus Family C1-set PF07654.15 CDW55769.1 - 2.1e-44 149.8 75.3 0.013 15.9 0.6 34.9 39 0 0 39 39 36 9 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 CDW55769.1 - 1.8e-33 114.9 25.1 0.23 11.7 0.0 29.3 32 1 0 32 32 28 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 CDW55769.1 - 1.2e-31 108.6 44.0 0.16 12.1 0.0 30.3 35 0 0 35 35 32 3 Izumo-like Immunoglobulin domain Ig_4 PF16680.5 CDW55769.1 - 5.5e-29 100.3 54.6 1.6 9.1 0.0 31.7 35 0 0 35 35 32 4 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 CDW55769.1 - 6.5e-28 96.1 7.8 1.4 8.6 0.0 22.1 26 0 0 26 26 23 5 Immunoglobulin domain RhoGEF PF00621.20 CDW55769.1 - 1.1e-17 64.8 2.7 2.3e-17 63.8 2.7 1.5 1 0 0 1 1 1 1 RhoGEF domain Ig_C17orf99 PF17736.1 CDW55769.1 - 3.9e-11 42.9 27.5 9.9 6.3 0.0 20.6 28 0 0 28 28 22 0 C17orf99 Ig domain Adeno_E3_CR1 PF02440.15 CDW55769.1 - 9.2e-07 28.6 39.0 0.58 10.0 0.2 17.5 22 0 0 22 22 19 2 Adenovirus E3 region protein CR1 Egh16-like PF11327.8 CDW55769.1 - 1.7e-06 28.6 12.9 1.4 9.3 0.2 9.2 6 1 1 10 10 8 2 Egh16-like virulence factor DUF4198 PF10670.9 CDW55769.1 - 5.4e-06 26.9 6.2 4.9 7.5 0.2 9.7 8 1 0 8 8 6 1 Domain of unknown function (DUF4198) fn3 PF00041.21 CDW55769.1 - 3.5e-05 24.0 0.1 0.00025 21.4 0.0 2.6 2 0 0 2 2 2 1 Fibronectin type III domain PKD PF00801.20 CDW55769.1 - 0.00011 22.0 1.4 4.2 7.3 0.0 6.0 6 0 0 6 6 6 1 PKD domain SH3_2 PF07653.17 CDW55769.1 - 0.00032 20.3 0.0 0.0028 17.3 0.0 2.9 1 0 0 1 1 1 1 Variant SH3 domain PKD_3 PF16820.5 CDW55769.1 - 0.017 14.9 16.6 19 5.1 0.0 12.6 15 0 0 15 15 13 0 PKD-like domain CDC48_2 PF02933.17 CDW55769.1 - 0.039 13.7 0.4 13 5.6 0.0 4.9 5 0 0 5 5 4 0 Cell division protein 48 (CDC48), domain 2 SH3_1 PF00018.28 CDW55769.1 - 0.059 13.0 0.3 0.23 11.1 0.0 2.3 2 0 0 2 2 2 0 SH3 domain DUF3244 PF11589.8 CDW55769.1 - 0.15 12.2 0.3 18 5.5 0.0 4.7 4 0 0 4 4 3 0 Domain of unknown function (DUF3244) DUF11 PF01345.18 CDW55769.1 - 0.7 10.2 11.3 1.9e+02 2.4 0.2 8.7 9 0 0 9 9 6 0 Domain of unknown function DUF11 PHTB1_N PF14727.6 CDW55770.1 - 4.9e-93 312.7 0.0 6.5e-93 312.3 0.0 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus PHTB1_C PF14728.6 CDW55770.1 - 9.8e-21 74.3 0.0 1.6e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 PTHB1 C-terminus PQQ_3 PF13570.6 CDW55770.1 - 0.0032 17.9 0.1 0.049 14.1 0.0 3.1 3 0 0 3 3 3 1 PQQ-like domain BBS1 PF14779.6 CDW55770.1 - 0.032 13.7 0.0 0.23 10.9 0.0 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 VWD PF00094.25 CDW55771.1 - 1.4e-37 129.4 0.4 2.5e-37 128.6 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type D domain VWC PF00093.18 CDW55771.1 - 1.2e-22 80.0 37.2 4.2e-11 43.0 19.2 2.7 2 0 0 2 2 2 2 von Willebrand factor type C domain TILa PF12714.7 CDW55771.1 - 3.3e-07 30.1 25.8 3.8e-05 23.5 11.4 3.0 2 1 0 2 2 2 2 TILa domain CFC PF09443.10 CDW55771.1 - 0.0072 16.1 5.6 0.0072 16.1 5.6 3.7 3 1 0 3 3 3 1 Cripto_Frl-1_Cryptic (CFC) VWC PF00093.18 CDW55772.1 - 5.6e-10 39.4 35.2 1.1e-05 25.7 7.6 2.5 3 0 0 3 3 3 2 von Willebrand factor type C domain DUF1859 PF08948.10 CDW55772.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1859) G-alpha PF00503.20 CDW55774.1 - 9.5e-109 363.8 2.0 1.2e-108 363.5 2.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CDW55774.1 - 2.8e-15 56.2 2.0 3.9e-12 46.0 0.4 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW55774.1 - 9.5e-05 21.9 1.1 0.0069 15.8 0.1 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CDW55774.1 - 0.00015 22.0 0.4 0.13 12.5 0.1 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CDW55774.1 - 0.0073 15.9 0.1 0.16 11.5 0.0 2.6 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 CDW55774.1 - 0.041 13.3 0.1 0.07 12.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 CDW55774.1 - 0.095 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP-synt_F6 PF05511.11 CDW55776.1 - 1.4e-18 67.1 0.0 2.3e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 Band_7 PF01145.25 CDW55776.1 - 0.00029 20.9 1.2 0.00044 20.3 1.2 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family mit_SMPDase PF14724.6 CDW55776.1 - 0.1 10.6 0.0 0.12 10.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial-associated sphingomyelin phosphodiesterase TerD PF02342.18 CDW55776.1 - 0.13 11.8 0.1 2.1 7.8 0.1 2.1 2 0 0 2 2 2 0 TerD domain Anoct_dimer PF16178.5 CDW55777.1 - 4.7e-22 78.8 0.0 5.4e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Anoctamin PF04547.12 CDW55778.1 - 5.7e-143 477.0 13.6 6.9e-143 476.7 13.6 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 CDW55778.1 - 3.2e-25 89.2 0.0 5.8e-25 88.3 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin DUF3176 PF11374.8 CDW55778.1 - 0.04 14.1 2.9 0.5 10.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3176) Rax2 PF12768.7 CDW55778.1 - 0.2 11.1 0.0 0.35 10.3 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity UPF0182 PF03699.13 CDW55778.1 - 0.28 9.3 7.6 0.038 12.1 2.8 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) CSD PF00313.22 CDW55779.1 - 1.5e-27 95.2 0.2 2.7e-27 94.4 0.2 1.5 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDW55779.1 - 0.073 12.8 0.7 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Ribonuclease B OB domain AA_permease PF00324.21 CDW55780.1 - 2.1e-80 270.6 46.7 2.8e-80 270.3 46.7 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 CDW55780.1 - 1e-26 94.0 2.2 9.3e-12 44.7 0.0 3.1 3 0 0 3 3 3 3 Solute carrier family 12 HLH PF00010.26 CDW55781.1 - 3.7e-11 42.8 0.3 7e-11 41.9 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.21 CDW55781.1 - 0.39 10.8 1.7 0.58 10.3 0.4 1.8 2 0 0 2 2 2 0 bZIP transcription factor Aminotran_1_2 PF00155.21 CDW55782.1 - 4.2e-40 138.0 0.0 5e-40 137.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CDW55782.1 - 0.022 13.3 0.0 0.029 12.9 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme IMD PF08397.11 CDW55783.1 - 2e-09 37.2 0.0 2.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain PNKP-ligase_C PF16536.5 CDW55783.1 - 0.011 16.0 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, C-terminal region PI3_PI4_kinase PF00454.27 CDW55785.1 - 1.7e-51 175.4 0.2 1.3e-50 172.5 0.2 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CDW55785.1 - 1.9e-46 157.8 0.0 3.6e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_p85B PF02192.16 CDW55785.1 - 2.3e-27 94.5 0.0 5.7e-27 93.3 0.0 1.7 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_C2 PF00792.24 CDW55785.1 - 8.5e-19 67.9 0.0 1.9e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 CDW55785.1 - 2.1e-07 31.1 0.0 1e-06 28.8 0.0 2.2 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain SUKH-3 PF14433.6 CDW55785.1 - 0.06 13.8 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 SUKH-3 immunity protein DUF647 PF04884.14 CDW55786.1 - 1.6e-87 293.1 3.0 2.2e-87 292.7 3.0 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis DHHC PF01529.20 CDW55787.1 - 1e-20 74.2 25.1 1.4e-20 73.8 25.1 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase Hat1_N PF10394.9 CDW55788.1 - 4.3e-25 88.8 0.1 8.5e-25 87.8 0.1 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 CDW55788.1 - 0.019 15.2 0.0 0.049 13.9 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family zf-CpG_bind_C PF12269.8 CDW55788.1 - 0.097 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Adeno_VII PF03228.14 CDW55789.1 - 2.5 8.8 5.9 0.65 10.6 1.7 2.1 2 1 1 3 3 3 0 Adenoviral core protein VII G-alpha PF00503.20 CDW55790.1 - 2e-125 418.6 7.1 2.4e-125 418.4 7.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CDW55790.1 - 1.2e-17 63.9 2.6 4.3e-13 49.1 0.8 2.9 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW55790.1 - 2e-06 27.4 5.0 0.00013 21.4 1.8 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CDW55790.1 - 0.00022 21.4 3.4 0.094 12.9 0.1 2.8 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 CDW55790.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Ras PF00071.22 CDW55790.1 - 0.016 14.8 3.8 0.56 9.8 1.5 2.7 2 1 0 2 2 2 0 Ras family AAA_29 PF13555.6 CDW55790.1 - 0.096 12.4 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ArfGap PF01412.18 CDW55791.1 - 3.7e-32 110.9 0.3 6.5e-32 110.1 0.3 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PHD PF00628.29 CDW55792.1 - 8e-13 48.1 21.5 2.6e-10 40.0 2.4 4.4 2 2 1 3 3 3 2 PHD-finger PHD_2 PF13831.6 CDW55792.1 - 0.0016 18.0 1.6 0.0016 18.0 1.6 4.5 4 0 0 4 4 4 2 PHD-finger C1_1 PF00130.22 CDW55792.1 - 0.041 13.8 17.2 0.091 12.7 0.4 3.8 3 1 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_7 PF02591.15 CDW55792.1 - 1 9.6 10.7 8.3 6.7 1.1 3.8 2 1 0 2 2 2 0 C4-type zinc ribbon domain BTB PF00651.31 CDW55794.1 - 1.6e-29 102.4 2.0 2.9e-29 101.5 0.6 2.1 2 1 1 3 3 3 1 BTB/POZ domain MATH PF00917.26 CDW55794.1 - 9.7e-07 28.9 0.0 1.7e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 MATH domain BACK PF07707.15 CDW55794.1 - 0.0063 16.6 1.0 0.15 12.2 0.0 3.4 4 0 0 4 4 4 1 BTB And C-terminal Kelch Cytochrom_NNT PF03264.14 CDW55795.1 - 0.017 14.8 0.3 0.024 14.3 0.3 1.2 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region zf-CCHC PF00098.23 CDW55796.1 - 1.1e-05 25.3 2.1 2.2e-05 24.3 2.1 1.5 1 0 0 1 1 1 1 Zinc knuckle FA_desaturase PF00487.24 CDW55797.1 - 3.5e-23 82.7 20.0 6.1e-23 82.0 20.0 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 CDW55797.1 - 3.4e-20 71.2 0.3 6.5e-20 70.3 0.3 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) SAS-6_N PF16531.5 CDW55798.1 - 6e-19 68.4 0.6 2.2e-18 66.6 0.6 2.0 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal ATG16 PF08614.11 CDW55798.1 - 0.00019 21.7 64.6 0.02 15.1 12.9 4.1 1 1 1 3 3 3 2 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 CDW55798.1 - 0.025 14.6 59.4 0.058 13.5 15.5 4.5 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein Pik1 PF11522.8 CDW55798.1 - 0.15 12.1 5.3 5.5 7.0 0.1 3.0 3 0 0 3 3 2 0 Yeast phosphatidylinositol-4-OH kinase Pik1 Spc7 PF08317.11 CDW55798.1 - 0.17 10.7 58.9 0.097 11.5 19.2 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein UPF0242 PF06785.11 CDW55798.1 - 0.22 11.6 63.3 0.61 10.2 10.9 3.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus KASH_CCD PF14662.6 CDW55798.1 - 0.27 11.0 65.4 0.055 13.3 15.2 3.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.6 CDW55798.1 - 0.51 9.6 45.3 1.8 7.8 20.6 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 CDW55798.1 - 0.63 10.3 21.4 1.1 9.6 3.6 4.4 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Rootletin PF15035.6 CDW55798.1 - 1.4 8.9 56.0 0.063 13.3 20.5 3.3 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion Baculo_PEP_C PF04513.12 CDW55798.1 - 1.7 8.7 30.4 0.42 10.6 2.3 4.3 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_II PF06009.12 CDW55798.1 - 2.3 8.2 38.5 0.11 12.5 12.7 3.7 1 1 2 3 3 3 0 Laminin Domain II DUF2203 PF09969.9 CDW55798.1 - 3 8.6 35.8 0.08 13.7 5.1 4.7 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) MatP_C PF17414.2 CDW55798.1 - 5.6 7.2 11.7 0.26 11.5 1.4 3.8 2 1 1 3 3 3 0 MatP C-terminal ribbon-helix-helix domain Filament PF00038.21 CDW55798.1 - 6.9 6.1 58.6 9 5.8 9.4 2.5 1 1 1 2 2 2 0 Intermediate filament protein UDG PF03167.19 CDW55799.1 - 7.5e-15 55.2 0.0 1.5e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily DUF1330 PF07045.11 CDW55799.1 - 0.079 13.3 0.1 0.2 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) TraB PF01963.17 CDW55800.1 - 2.3e-24 86.7 0.0 4e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 TraB family AbrB-like PF14250.6 CDW55800.1 - 0.11 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 AbrB-like transcriptional regulator Cpn60_TCP1 PF00118.24 CDW55801.1 - 1e-107 360.8 3.3 9.1e-101 337.9 2.4 2.2 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family TubC_N PF18563.1 CDW55801.1 - 0.054 13.5 0.0 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 TubC N-terminal docking domain Ran_BP1 PF00638.18 CDW55802.1 - 5.7e-11 42.7 0.0 1.1e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 RanBP1 domain RIBIOP_C PF04950.12 CDW55803.1 - 4.5e-104 348.0 0.0 6e-104 347.6 0.0 1.2 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CDW55803.1 - 5e-13 49.0 0.0 3.8e-12 46.1 0.0 2.2 1 1 0 1 1 1 1 AARP2CN (NUC121) domain Ion_trans_2 PF07885.16 CDW55804.1 - 8.5e-34 115.4 26.2 3e-17 62.4 0.8 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CDW55804.1 - 2.1e-07 30.4 16.5 2.7e-06 26.8 1.3 2.7 2 1 1 3 3 3 2 Ion transport protein Lig_chan PF00060.26 CDW55804.1 - 0.0028 17.5 0.1 0.0028 17.5 0.1 2.2 2 1 0 2 2 2 1 Ligand-gated ion channel IRK PF01007.20 CDW55804.1 - 0.011 15.5 4.7 0.092 12.6 0.0 2.6 3 0 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain Herpes_IE68 PF02479.16 CDW55805.1 - 0.13 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus immediate early protein Birna_VP3 PF01767.16 CDW55806.1 - 0.056 13.5 2.7 0.81 9.7 0.1 2.6 3 0 0 3 3 3 0 Birnavirus VP3 protein Brix PF04427.18 CDW55807.1 - 3.2e-26 92.6 0.2 3.5e-26 92.5 0.2 1.0 1 0 0 1 1 1 1 Brix domain RCC1 PF00415.18 CDW55808.1 - 1.1e-23 83.6 0.1 1.1e-09 38.7 0.0 5.1 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat VPS9 PF02204.18 CDW55808.1 - 2.5e-19 69.4 0.2 4.6e-19 68.6 0.2 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RCC1_2 PF13540.6 CDW55808.1 - 2.6e-18 65.3 11.7 5.9e-08 32.3 0.3 6.1 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat MORN PF02493.20 CDW55808.1 - 5.3e-09 35.5 5.5 0.014 15.2 0.5 4.7 5 0 0 5 5 5 3 MORN repeat WD40 PF00400.32 CDW55809.1 - 5.2e-53 175.8 31.0 4e-09 37.0 0.2 8.5 7 2 1 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55809.1 - 8.1e-20 70.9 5.4 3.2e-05 24.1 0.0 5.2 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CDW55809.1 - 0.0005 19.9 0.1 11 6.1 0.0 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CDW55809.1 - 0.0017 17.4 0.0 0.68 8.8 0.0 3.2 5 0 0 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CDW55809.1 - 0.002 18.0 0.0 0.35 10.7 0.0 3.3 2 2 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CDW55809.1 - 0.0029 16.3 2.4 4.7 5.7 0.0 3.6 2 2 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 CDW55809.1 - 0.0036 16.7 0.0 2.6 7.3 0.0 3.4 3 1 0 3 3 3 1 WD40-like domain Proteasome_A_N PF10584.9 CDW55809.1 - 0.52 10.0 4.5 3.3 7.5 0.1 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature EGF_CA PF07645.15 CDW55810.1 - 6.5e-48 160.7 131.9 1e-11 44.9 6.1 10.6 10 2 1 11 11 11 7 Calcium-binding EGF domain EGF_3 PF12947.7 CDW55810.1 - 8.2e-28 96.3 125.7 2.7e-10 40.2 8.1 9.8 8 2 0 9 9 9 7 EGF domain cEGF PF12662.7 CDW55810.1 - 8.6e-19 67.1 86.6 1.7e-05 24.6 2.4 10.8 10 0 0 10 10 10 6 Complement Clr-like EGF-like NIDO PF06119.14 CDW55810.1 - 1.6e-13 51.4 0.1 1.4e-07 32.3 0.0 2.6 2 0 0 2 2 2 2 Nidogen-like EGF_MSP1_1 PF12946.7 CDW55810.1 - 8.2e-13 48.2 94.9 5.8e-05 23.0 6.1 8.9 8 0 0 8 8 8 7 MSP1 EGF domain 1 hEGF PF12661.7 CDW55810.1 - 1.3e-11 44.7 98.7 5.9e-05 23.6 3.2 10.8 11 0 0 11 11 11 6 Human growth factor-like EGF EGF PF00008.27 CDW55810.1 - 2.8e-10 40.3 112.6 2.2e-05 24.7 6.3 10.8 9 2 2 11 11 11 7 EGF-like domain Plasmod_Pvs28 PF06247.11 CDW55810.1 - 3.6e-10 40.0 97.9 0.0015 18.8 2.5 9.5 9 0 0 9 9 9 6 Pvs28 EGF domain FXa_inhibition PF14670.6 CDW55810.1 - 0.0052 17.0 107.2 0.011 16.0 7.1 10.2 8 3 2 10 10 10 6 Coagulation Factor Xa inhibitory site WD40 PF00400.32 CDW55811.1 - 6.9e-11 42.5 4.6 0.5 11.3 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55811.1 - 0.00064 20.0 0.0 1.1 9.6 0.0 4.2 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain U3_assoc_6 PF08640.11 CDW55811.1 - 0.12 12.4 0.5 0.3 11.2 0.5 1.7 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 Pro_isomerase PF00160.21 CDW55812.1 - 1.5e-48 165.1 0.3 2.8e-48 164.1 0.3 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 CDW55812.1 - 7.2e-07 29.8 0.5 0.04 14.8 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55812.1 - 3.6e-05 24.0 0.0 0.74 10.2 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain GILT PF03227.16 CDW55813.1 - 7.4e-31 106.5 0.2 1.5e-30 105.6 0.2 1.5 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) SapA PF02199.15 CDW55813.1 - 0.003 17.8 4.2 0.0037 17.5 2.2 2.3 2 0 0 2 2 2 1 Saposin A-type domain BBL5 PF07289.11 CDW55814.1 - 2.7e-124 414.6 0.1 3.1e-124 414.4 0.1 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein Vps36_ESCRT-II PF11605.8 CDW55814.1 - 2.7e-06 27.5 0.0 0.0063 16.7 0.0 2.5 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 CDW55814.1 - 0.00014 22.1 0.1 0.065 13.6 0.0 2.4 2 0 0 2 2 2 2 Bacterial PH domain SHD1 PF03983.12 CDW55814.1 - 0.063 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 SLA1 homology domain 1, SHD1 SH2 PF00017.24 CDW55815.1 - 1e-09 38.4 0.0 0.24 11.5 0.0 4.2 4 0 0 4 4 4 3 SH2 domain Peptidase_S8 PF00082.22 CDW55816.1 - 6.3e-29 101.2 5.8 8.6e-29 100.7 5.8 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 CDW55816.1 - 4.4e-26 90.7 0.1 7.2e-26 90.0 0.1 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain Furin-like_2 PF15913.5 CDW55816.1 - 9.9e-09 35.3 39.8 2.1e-07 31.1 18.1 3.6 1 1 1 2 2 2 2 Furin-like repeat, cysteine-rich MCM PF00493.23 CDW55817.1 - 2.4e-97 324.5 0.0 3.5e-97 323.9 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDW55817.1 - 1.1e-37 128.7 1.3 2.1e-37 127.8 1.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDW55817.1 - 6.5e-27 93.8 0.8 1.8e-26 92.3 0.8 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDW55817.1 - 9.4e-14 51.9 0.0 2.2e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CDW55817.1 - 6.3e-06 25.7 0.0 0.00048 19.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDW55817.1 - 0.0019 18.2 0.1 0.01 15.8 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDW55817.1 - 0.003 17.4 0.0 0.01 15.7 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CDW55817.1 - 0.038 13.7 0.0 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain Sushi PF00084.20 CDW55818.1 - 9.1e-23 80.6 16.6 5.9e-09 36.4 0.4 5.8 5 1 0 5 5 5 4 Sushi repeat (SCR repeat) HRM PF02793.22 CDW55818.1 - 0.0075 16.5 13.7 0.48 10.8 0.1 5.3 5 1 0 5 5 5 2 Hormone receptor domain Herpes_UL73 PF03554.13 CDW55818.1 - 1.5 8.9 4.9 2.2 8.4 0.9 3.1 4 0 0 4 4 4 0 UL73 viral envelope glycoprotein Globin PF00042.22 CDW55819.1 - 6.8e-16 58.8 0.5 1.3e-15 57.9 0.3 1.6 2 0 0 2 2 2 1 Globin PI_PP_C PF18365.1 CDW55819.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide phosphatase C-terminal domain SOSSC PF15925.5 CDW55820.1 - 0.00031 22.0 1.5 0.026 15.8 0.0 2.0 1 1 1 2 2 2 2 SOSS complex subunit C TSP_1 PF00090.19 CDW55821.1 - 0.039 14.2 0.9 0.14 12.4 0.9 1.9 1 0 0 1 1 1 0 Thrombospondin type 1 domain Glucosamine_iso PF01182.20 CDW55822.1 - 7.1e-51 173.2 0.0 8.7e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase ECR1_N PF14382.6 CDW55823.1 - 7.2e-09 35.3 0.1 1.4e-08 34.4 0.1 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 CDW55823.1 - 9.3e-09 35.5 0.4 2.2e-08 34.3 0.4 1.7 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 CDW55823.1 - 0.0054 17.3 1.2 2.2 8.9 0.1 2.5 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 TGT PF01702.18 CDW55824.1 - 8.7e-134 446.1 0.0 1.1e-133 445.8 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase ubiquitin PF00240.23 CDW55825.1 - 0.00084 19.0 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CDW55825.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.5 1 0 0 1 1 1 0 UBA/TS-N domain TyeA PF09059.10 CDW55825.1 - 0.24 11.5 1.4 0.45 10.6 0.3 2.0 2 0 0 2 2 2 0 TyeA JAB PF01398.21 CDW55826.1 - 5.6e-33 113.4 0.4 1e-32 112.6 0.4 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 CDW55826.1 - 1.4e-07 32.3 2.4 4.9e-07 30.6 0.9 2.2 2 0 0 2 2 2 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 CDW55826.1 - 0.00019 21.2 0.0 0.00038 20.2 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 CDW55826.1 - 0.035 14.1 0.3 0.081 13.0 0.3 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) Sec1 PF00995.23 CDW55827.1 - 3.1e-93 314.0 0.0 3.6e-93 313.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family PDZ PF00595.24 CDW55828.1 - 4.8e-64 212.7 2.9 9.3e-16 58.0 0.0 5.2 5 0 0 5 5 5 5 PDZ domain PDZ_6 PF17820.1 CDW55828.1 - 1e-48 163.0 15.2 3.5e-11 42.8 0.1 5.3 5 0 0 5 5 5 5 PDZ domain PDZ_2 PF13180.6 CDW55828.1 - 2.3e-22 79.1 0.0 1.3e-05 25.4 0.0 5.3 5 0 0 5 5 5 5 PDZ domain WW PF00397.26 CDW55828.1 - 3.6e-12 46.1 4.0 1.8e-07 31.1 0.4 2.4 2 0 0 2 2 2 2 WW domain Pkinase PF00069.25 CDW55829.1 - 1.2e-24 87.1 0.0 1.5e-24 86.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55829.1 - 2.9e-13 49.7 0.0 4.2e-13 49.2 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW55829.1 - 0.05 13.5 0.1 6.5 6.6 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family UCR_TM PF02921.14 CDW55830.1 - 8.8e-19 67.8 0.0 1.5e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 CDW55830.1 - 6e-10 38.9 0.1 1.2e-09 38.0 0.1 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain MARVEL PF01284.23 CDW55831.1 - 9.5e-19 67.9 9.7 1.4e-18 67.3 9.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain Frag1 PF10277.9 CDW55831.1 - 0.0046 16.5 1.4 0.0046 16.5 1.4 2.0 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family FtsX PF02687.21 CDW55831.1 - 7.4 7.1 8.6 5.2 7.6 4.0 2.4 1 1 1 2 2 2 0 FtsX-like permease family SelK_SelG PF10961.8 CDW55832.1 - 0.026 15.1 0.0 0.039 14.6 0.0 1.3 1 1 0 1 1 1 0 Selenoprotein SelK_SelG ChlI PF13541.6 CDW55832.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.4 2 0 0 2 2 2 0 Subunit ChlI of Mg-chelatase wnt PF00110.19 CDW55833.1 - 4.2e-112 374.7 26.1 5e-112 374.5 26.1 1.0 1 0 0 1 1 1 1 wnt family EMP24_GP25L PF01105.24 CDW55834.1 - 1.6e-42 145.5 0.3 2.1e-42 145.2 0.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ABC_tran PF00005.27 CDW55835.1 - 3.4e-55 186.3 0.0 6.1e-31 107.8 0.1 2.3 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CDW55835.1 - 8.4e-36 124.0 19.9 2.5e-25 89.7 6.7 3.8 3 1 1 4 4 4 2 ABC transporter transmembrane region SMC_N PF02463.19 CDW55835.1 - 1.3e-11 44.4 4.1 0.014 14.8 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDW55835.1 - 2.6e-08 34.0 0.0 0.031 14.1 0.0 3.5 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CDW55835.1 - 2.8e-07 30.6 0.0 0.041 14.0 0.0 3.6 3 1 0 3 3 3 2 50S ribosome-binding GTPase AAA_29 PF13555.6 CDW55835.1 - 4.6e-07 29.5 0.1 0.021 14.6 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CDW55835.1 - 8.1e-07 29.7 3.9 0.0093 16.5 0.7 2.9 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 CDW55835.1 - 2.6e-05 23.4 0.0 0.00066 18.8 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 CDW55835.1 - 2.8e-05 24.1 0.0 0.11 12.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase DUF87 PF01935.17 CDW55835.1 - 7.2e-05 23.0 0.5 0.0066 16.6 0.1 2.7 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_16 PF13191.6 CDW55835.1 - 0.0022 18.4 0.1 0.41 11.0 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDW55835.1 - 0.0032 17.2 0.2 0.12 12.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CDW55835.1 - 0.017 14.3 0.1 6.8 5.8 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain SbcCD_C PF13558.6 CDW55835.1 - 0.017 15.3 0.0 3.3 8.0 0.0 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit CCB2_CCB4 PF11152.8 CDW55835.1 - 0.046 13.0 0.1 0.85 8.9 0.0 2.3 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 ATP-synt_ab PF00006.25 CDW55835.1 - 0.05 13.2 0.0 5.8 6.5 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain TrwB_AAD_bind PF10412.9 CDW55835.1 - 0.056 12.3 0.1 2 7.3 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain KAP_NTPase PF07693.14 CDW55835.1 - 0.061 12.6 0.1 0.19 11.0 0.0 1.8 2 0 0 2 2 2 0 KAP family P-loop domain Adeno_IVa2 PF02456.15 CDW55835.1 - 0.097 11.4 0.0 0.71 8.6 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein Dynamin_N PF00350.23 CDW55835.1 - 0.12 12.4 1.5 4.5 7.3 0.3 2.6 2 0 0 2 2 2 0 Dynamin family MeaB PF03308.16 CDW55835.1 - 0.13 11.2 0.1 7.4 5.5 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase_2 PF01637.18 CDW55835.1 - 0.16 11.9 1.4 0.49 10.3 0.1 2.5 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CDW55835.1 - 0.16 12.3 0.2 6.1 7.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ATP_bind_1 PF03029.17 CDW55835.1 - 0.19 11.4 2.3 1.7 8.3 0.0 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 CDW55835.1 - 0.22 12.1 1.2 25 5.4 0.7 2.8 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDW55835.1 - 6.1 7.1 8.7 30 4.9 0.1 3.6 3 1 0 3 3 3 0 AAA domain T5orf172 PF10544.9 CDW55837.1 - 0.0042 17.6 0.1 0.031 14.8 0.1 2.6 1 0 0 1 1 1 1 T5orf172 domain HSBP1 PF06825.12 CDW55837.1 - 0.015 15.1 1.3 4.8 7.1 0.0 3.1 2 0 0 2 2 2 0 Heat shock factor binding protein 1 P4Ha_N PF08336.11 CDW55837.1 - 0.25 11.4 0.1 0.25 11.4 0.1 5.0 5 1 1 6 6 6 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DASH_Dad1 PF08649.10 CDW55837.1 - 1.1 9.6 4.5 27 5.1 0.3 3.5 2 0 0 2 2 2 0 DASH complex subunit Dad1 YrbL-PhoP_reg PF10707.9 CDW55839.1 - 0.0001 21.9 2.0 0.44 10.0 0.1 3.2 2 1 1 3 3 3 2 PhoP regulatory network protein YrbL Feld-I_B PF09252.10 CDW55839.1 - 0.064 13.2 0.7 0.33 10.9 0.0 2.5 3 0 0 3 3 3 0 Allergen Fel d I-B chain Patched PF02460.18 CDW55840.1 - 9.5e-160 533.4 11.6 1.1e-159 533.2 11.6 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW55840.1 - 1.4e-21 76.9 3.1 1.4e-21 76.9 3.1 2.8 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 CDW55840.1 - 0.00016 20.8 0.0 0.00016 20.8 0.0 2.6 2 1 0 2 2 2 1 MMPL family ACR_tran PF00873.19 CDW55840.1 - 1.2 6.7 7.9 1.7 6.2 7.9 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family 7TM_GPCR_Srx PF10328.9 CDW55841.1 - 5.2e-29 101.7 28.3 9.2e-29 100.9 28.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srv PF10323.9 CDW55841.1 - 1.5e-12 47.5 23.8 1.5e-12 47.5 23.8 1.8 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_1 PF00001.21 CDW55841.1 - 4.7e-10 39.2 22.6 6.9e-10 38.7 22.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) CBP_BcsF PF11120.8 CDW55841.1 - 0.02 15.0 0.1 0.077 13.1 0.1 2.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF Planc_extracel PF07595.12 CDW55841.1 - 0.27 11.1 2.1 0.47 10.3 2.1 1.4 1 0 0 1 1 1 0 Planctomycete extracellular Trypsin PF00089.26 CDW55842.1 - 2.9e-192 635.4 9.5 7.1e-28 97.9 0.0 14.0 10 3 3 13 13 13 13 Trypsin Trypsin_2 PF13365.6 CDW55842.1 - 1.8e-26 93.9 1.1 0.00035 21.5 0.0 8.0 8 1 0 8 8 8 5 Trypsin-like peptidase domain Gln-synt_N PF03951.19 CDW55842.1 - 8.2e-07 28.7 0.0 10 5.9 0.0 5.6 6 0 0 6 6 6 1 Glutamine synthetase, beta-Grasp domain DUF1638 PF07796.11 CDW55842.1 - 0.0021 18.2 1.1 5.8 7.0 0.0 4.5 5 0 0 5 5 5 1 Protein of unknown function (DUF1638) PPR_2 PF13041.6 CDW55842.1 - 0.017 15.3 0.0 2.6e+02 1.9 0.0 5.3 6 0 0 6 6 6 0 PPR repeat family Atypical_Card PF18461.1 CDW55842.1 - 0.028 14.6 0.0 3.5 7.9 0.0 3.8 3 0 0 3 3 3 0 Atypical caspase recruitment domain PPR_1 PF12854.7 CDW55842.1 - 0.51 10.1 1.9 1.4e+02 2.3 0.0 4.4 6 0 0 6 6 6 0 PPR repeat KSHV_K1 PF11049.8 CDW55842.1 - 1.4 8.9 3.1 49 4.0 0.0 3.2 3 0 0 3 3 3 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus Trypsin PF00089.26 CDW55843.1 - 3e-55 187.4 0.0 1.4e-28 100.3 0.0 2.8 1 1 1 2 2 2 2 Trypsin Trypsin_2 PF13365.6 CDW55843.1 - 7e-07 30.3 0.0 0.035 15.0 0.0 2.3 1 1 1 2 2 2 2 Trypsin-like peptidase domain C2 PF00168.30 CDW55843.1 - 0.038 14.3 0.0 0.077 13.3 0.0 1.4 1 0 0 1 1 1 0 C2 domain Trypsin PF00089.26 CDW55844.1 - 2.4e-41 142.0 0.0 2.9e-41 141.7 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW55844.1 - 9.1e-05 23.4 0.0 0.00017 22.5 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain SAM_1 PF00536.30 CDW55845.1 - 8.8e-26 90.1 2.0 1.2e-11 44.8 0.0 3.4 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW55845.1 - 4.2e-23 81.2 1.5 2.4e-09 37.2 0.1 3.6 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) UPF0242 PF06785.11 CDW55845.1 - 0.00027 21.1 3.3 0.00054 20.1 3.3 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF5344 PF17279.2 CDW55845.1 - 0.029 14.9 1.3 0.029 14.9 1.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5344) FAM76 PF16046.5 CDW55845.1 - 0.075 12.4 10.2 0.14 11.5 10.2 1.4 1 0 0 1 1 1 0 FAM76 protein DUF1640 PF07798.11 CDW55845.1 - 0.28 11.2 11.7 0.55 10.3 11.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4805 PF16063.5 CDW55845.1 - 0.39 10.0 9.1 0.16 11.3 5.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) Spc7 PF08317.11 CDW55845.1 - 1.8 7.3 24.3 0.31 9.9 18.5 2.0 1 1 0 2 2 2 0 Spc7 kinetochore protein Lzipper-MIP1 PF14389.6 CDW55845.1 - 2.9 8.3 16.3 0.088 13.1 1.8 2.7 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 ADIP PF11559.8 CDW55845.1 - 8.9 6.4 21.5 8.1 6.5 2.7 3.3 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Voldacs PF03517.13 CDW55846.1 - 0.055 13.6 1.4 0.062 13.4 1.4 1.1 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling TPR_14 PF13428.6 CDW55847.1 - 0.0062 17.3 0.0 0.033 15.0 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat Glyco_transf_90 PF05686.12 CDW55847.1 - 0.009 15.0 0.0 0.016 14.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 90 Holin_BhlA PF10960.8 CDW55847.1 - 0.051 13.5 0.0 0.54 10.3 0.0 2.5 2 0 0 2 2 2 0 BhlA holin family TPR_4 PF07721.14 CDW55847.1 - 0.068 13.8 0.0 0.21 12.3 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Collagen PF01391.18 CDW55848.1 - 3.2e-26 90.8 96.7 2.6e-09 36.7 29.1 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW55848.1 - 2.6e-09 37.0 1.1 5.5e-09 35.9 0.3 1.7 1 1 1 2 2 2 1 Nematode cuticle collagen N-terminal domain Collagen PF01391.18 CDW55849.1 - 1.5e-26 91.9 100.2 1.4e-10 40.7 36.5 4.0 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW55849.1 - 3.7e-06 26.9 0.1 4.7e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain BTB PF00651.31 CDW55850.1 - 8.3e-08 32.4 0.0 2.2e-07 31.1 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain AcylCoA_dehyd_C PF12186.8 CDW55850.1 - 0.0022 18.1 0.3 0.96 9.6 0.1 2.2 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase C terminal DUF5010_C PF18099.1 CDW55850.1 - 0.075 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 DUF5010 C-terminal domain zf-H2C2_2 PF13465.6 CDW55851.1 - 7.1e-29 98.9 101.4 4.9e-10 39.4 0.7 14.3 16 0 0 16 16 16 9 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW55851.1 - 6.7e-23 79.4 123.1 0.0012 19.5 2.9 14.9 15 0 0 15 15 15 11 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW55851.1 - 1.8e-18 65.9 130.9 0.00057 20.2 2.5 15.0 16 0 0 16 16 16 11 Zinc finger, C2H2 type zf-Di19 PF05605.12 CDW55851.1 - 2e-06 28.0 68.6 0.034 14.5 3.3 10.6 7 4 1 9 9 9 5 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 CDW55851.1 - 8.8e-05 22.7 66.0 0.0063 16.8 0.5 11.5 12 0 0 12 12 12 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW55851.1 - 0.00012 22.0 3.1 0.005 16.8 0.5 12.0 12 0 0 12 12 12 6 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CDW55851.1 - 0.049 14.0 0.6 0.049 14.0 0.6 12.0 5 4 5 10 10 10 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 CDW55851.1 - 3.9 8.2 50.8 2.4 8.8 0.1 10.9 5 4 6 12 12 12 0 Zinc finger C2H2-type, 3 repeats Clat_adaptor_s PF01217.20 CDW55852.1 - 2.6e-49 166.8 1.0 3.2e-49 166.5 1.0 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ion_trans PF00520.31 CDW55853.1 - 3.8e-41 140.9 16.2 5.2e-41 140.5 16.2 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 CDW55853.1 - 4.4e-28 97.5 0.0 7.9e-28 96.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 CDW55853.1 - 7.7e-10 38.6 7.8 7.7e-10 38.6 7.8 2.5 2 1 0 2 2 2 1 Ion channel BTB_3 PF16017.5 CDW55853.1 - 0.079 13.1 0.2 0.29 11.2 0.0 2.1 2 1 0 2 2 2 0 BTB/POZ domain VWC PF00093.18 CDW55854.1 - 3.8e-19 68.7 63.2 9.8e-10 38.6 14.6 4.5 4 0 0 4 4 4 4 von Willebrand factor type C domain CHRD PF07452.12 CDW55854.1 - 1.1e-14 55.3 0.0 2.8e-08 34.7 0.0 4.0 4 0 0 4 4 4 3 CHRD domain Metallophos PF00149.28 CDW55855.1 - 8.8e-37 127.6 0.0 1.1e-36 127.3 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FH2 PF02181.23 CDW55856.1 - 5.1e-86 289.1 0.3 5.1e-86 289.1 0.3 1.6 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 CDW55856.1 - 9e-29 100.5 7.2 1.2e-28 100.1 5.2 2.2 2 1 1 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 CDW55856.1 - 1.1e-11 44.7 5.0 6.1e-11 42.2 1.9 3.1 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain DUF3584 PF12128.8 CDW55856.1 - 0.012 13.2 7.4 0.019 12.5 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) COG5 PF10392.9 CDW55856.1 - 0.12 12.5 1.4 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Mito_fiss_reg PF05308.11 CDW55856.1 - 0.25 11.4 3.3 0.49 10.4 3.3 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator Golgin_A5 PF09787.9 CDW55856.1 - 0.83 9.1 13.2 1.2 8.6 11.9 1.8 2 0 0 2 2 2 0 Golgin subfamily A member 5 SUI1 PF01253.22 CDW55857.1 - 3e-17 62.9 0.2 1.2e-16 61.0 0.2 2.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 CDW55857.1 - 2.1e-16 60.4 0.4 6.6e-16 58.8 0.4 2.0 1 0 0 1 1 1 1 Pre-PUA-like domain PIH1 PF08190.12 CDW55857.1 - 4.1e-10 39.4 0.0 1.3e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 PIH1 N-terminal domain PUA PF01472.20 CDW55857.1 - 2e-07 30.8 0.0 7.6e-07 29.0 0.0 2.0 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 CDW55857.1 - 0.00043 20.5 3.4 0.0017 18.6 0.4 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF1947) DUF3845 PF12956.7 CDW55857.1 - 0.083 12.3 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure Cpn60_TCP1 PF00118.24 CDW55858.1 - 1.5e-12 47.0 0.0 6.6e-12 44.8 0.0 1.8 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Got1 PF04178.12 CDW55859.1 - 3e-22 79.2 10.4 3.6e-22 78.9 10.4 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family PAN_1 PF00024.26 CDW55860.1 - 3.2e-17 62.3 7.7 2e-09 37.3 0.4 2.6 2 0 0 2 2 2 2 PAN domain PAN_4 PF14295.6 CDW55860.1 - 0.0005 19.9 5.5 0.078 12.9 1.3 2.9 2 0 0 2 2 2 2 PAN domain PAN_2 PF08276.11 CDW55860.1 - 0.00067 19.7 7.3 0.0036 17.4 1.0 3.1 2 0 0 2 2 2 2 PAN-like domain EB PF01683.18 CDW55861.1 - 2.8e-11 43.5 84.3 0.0016 18.7 4.5 8.2 2 2 7 9 9 9 9 EB module Dickkopf_N PF04706.12 CDW55861.1 - 0.00077 19.9 83.3 0.034 14.6 10.6 7.3 5 3 2 7 7 7 5 Dickkopf N-terminal cysteine-rich region EB PF01683.18 CDW55862.1 - 2e-05 24.8 31.9 0.0071 16.6 6.6 3.5 2 2 1 3 3 3 3 EB module Dickkopf_N PF04706.12 CDW55862.1 - 5.1e-05 23.7 36.0 0.0028 18.1 10.4 3.9 2 2 1 3 3 3 3 Dickkopf N-terminal cysteine-rich region cNMP_binding PF00027.29 CDW55863.1 - 9.6e-39 131.4 0.0 4e-13 49.3 0.0 3.9 4 0 0 4 4 4 3 Cyclic nucleotide-binding domain Patatin PF01734.22 CDW55863.1 - 2.2e-23 83.5 0.8 1.5e-21 77.5 0.8 2.6 1 1 0 1 1 1 1 Patatin-like phospholipase AAA_31 PF13614.6 CDW55863.1 - 0.023 14.6 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain tRNA-synt_2 PF00152.20 CDW55864.1 - 7.3e-97 324.2 0.0 8.9e-97 323.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDW55864.1 - 1.4e-09 37.8 0.0 3.1e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDW55864.1 - 0.063 12.8 0.1 0.77 9.2 0.0 2.4 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) DAGK_acc PF00609.19 CDW55865.1 - 8.8e-53 178.9 0.0 4.9e-52 176.5 0.0 2.1 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain C1_1 PF00130.22 CDW55865.1 - 5.9e-24 83.7 52.5 7.2e-10 38.6 14.2 3.5 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_cat PF00781.24 CDW55865.1 - 2.7e-21 75.5 0.0 5.6e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain RA PF00788.23 CDW55865.1 - 5.2e-21 75.1 0.1 1.7e-12 47.8 0.0 3.1 4 0 0 4 4 4 2 Ras association (RalGDS/AF-6) domain PHD PF00628.29 CDW55865.1 - 0.0043 16.9 4.2 0.0043 16.9 4.2 4.0 3 0 0 3 3 3 1 PHD-finger RRM_occluded PF16842.5 CDW55865.1 - 0.018 14.9 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif C1_2 PF03107.16 CDW55865.1 - 4.2 7.8 41.4 0.07 13.5 3.0 3.9 3 1 1 4 4 4 0 C1 domain Myosin_head PF00063.21 CDW55866.1 - 3.3e-194 646.9 0.0 5.9e-129 431.3 0.0 2.2 1 1 1 2 2 2 2 Myosin head (motor domain) MyTH4 PF00784.17 CDW55866.1 - 1.5e-49 167.0 1.0 2.6e-27 95.4 0.1 3.7 2 1 0 2 2 2 2 MyTH4 domain FERM_M PF00373.18 CDW55866.1 - 3.6e-23 82.2 0.0 5.7e-17 62.2 0.0 3.5 3 0 0 3 3 3 2 FERM central domain IQ PF00612.27 CDW55866.1 - 0.00034 20.1 13.5 0.017 14.8 0.9 3.6 3 0 0 3 3 3 2 IQ calmodulin-binding motif FERM_N PF09379.10 CDW55866.1 - 0.00067 19.5 0.0 0.54 10.2 0.0 2.8 2 0 0 2 2 2 2 FERM N-terminal domain AAA_22 PF13401.6 CDW55866.1 - 0.018 15.3 0.0 0.13 12.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain RA PF00788.23 CDW55866.1 - 0.023 15.3 0.0 0.16 12.7 0.0 2.4 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain AAA_16 PF13191.6 CDW55866.1 - 0.072 13.5 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Sec63 PF02889.16 CDW55867.1 - 6.3e-93 310.6 0.0 3.4e-57 193.6 0.0 2.9 2 1 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CDW55867.1 - 6e-49 166.2 0.6 3.1e-25 88.9 0.2 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 CDW55867.1 - 1e-25 90.7 0.0 2.4e-13 50.5 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDW55867.1 - 3.3e-15 56.4 0.0 1.6e-06 28.5 0.0 3.6 2 1 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 CDW55867.1 - 1.4e-08 35.1 1.0 0.00029 21.1 0.1 3.5 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CDW55867.1 - 7e-06 25.9 0.2 0.016 14.9 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CDW55867.1 - 8.7e-05 22.9 0.3 0.15 12.4 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 CDW55867.1 - 0.00093 19.6 0.2 2.4 8.6 0.4 3.5 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDW55867.1 - 0.0035 16.9 0.7 1.1 8.8 0.2 2.5 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 CDW55867.1 - 0.0047 16.0 0.0 1.5 7.8 0.0 3.0 3 0 0 3 3 3 1 Type II/IV secretion system protein PhoH PF02562.16 CDW55867.1 - 0.024 14.1 0.0 3.3 7.1 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein IstB_IS21 PF01695.17 CDW55867.1 - 0.034 13.9 0.4 1.2 8.8 0.0 3.3 4 0 0 4 4 4 0 IstB-like ATP binding protein DUF4143 PF13635.6 CDW55867.1 - 0.13 12.5 0.1 0.64 10.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4143) Activin_recp PF01064.23 CDW55868.1 - 0.0012 19.9 1.8 0.0022 19.0 1.8 1.4 1 1 0 1 1 1 1 Activin types I and II receptor domain Toxin_TOLIP PF00087.21 CDW55868.1 - 0.002 18.4 0.1 0.002 18.4 0.1 2.1 2 0 0 2 2 2 1 Snake toxin and toxin-like protein Alpha-amylase PF00128.24 CDW55869.1 - 1.3e-95 320.8 0.2 1.8e-95 320.4 0.2 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain BTD PF09270.10 CDW55870.1 - 1e-66 223.9 0.0 1.6e-66 223.3 0.0 1.3 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 CDW55870.1 - 3.1e-47 161.0 1.2 5e-47 160.3 1.2 1.3 1 0 0 1 1 1 1 LAG1, DNA binding Cation_ATPase_C PF00689.21 CDW55871.1 - 5.6e-44 150.0 6.5 5.6e-44 150.0 6.5 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CDW55871.1 - 4.1e-35 120.9 6.5 4.9e-27 94.6 1.6 3.4 4 0 0 4 4 4 2 E1-E2 ATPase Cation_ATPase PF13246.6 CDW55871.1 - 1.7e-18 66.5 0.0 4.5e-18 65.1 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDW55871.1 - 9.6e-15 55.4 0.1 3.2e-13 50.4 0.1 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CDW55871.1 - 5e-14 51.7 0.0 1.2e-13 50.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus ATP_Ca_trans_C PF12424.8 CDW55871.1 - 5.6e-09 36.3 2.5 4.1e-08 33.6 0.4 2.9 2 0 0 2 2 2 1 Plasma membrane calcium transporter ATPase C terminal Hydrolase_3 PF08282.12 CDW55871.1 - 2.6e-06 27.4 0.7 0.00015 21.6 0.2 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase LRRC37AB_C PF14914.6 CDW55871.1 - 0.024 14.5 0.0 0.069 13.1 0.0 1.7 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF202 PF02656.15 CDW55871.1 - 2.4 8.7 6.0 66 4.1 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF202) SH3_9 PF14604.6 CDW55872.1 - 4.2e-39 132.2 3.4 6.7e-16 57.9 0.4 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 CDW55872.1 - 5.8e-38 128.3 0.1 1.4e-12 47.0 0.0 3.6 3 0 0 3 3 3 3 SH3 domain SH3_2 PF07653.17 CDW55872.1 - 8.2e-33 111.9 0.6 2.7e-09 36.6 0.0 3.5 3 0 0 3 3 3 3 Variant SH3 domain hSH3 PF14603.6 CDW55872.1 - 0.0011 19.4 0.0 0.029 14.8 0.0 2.4 2 0 0 2 2 2 1 Helically-extended SH3 domain SSXT PF05030.12 CDW55872.1 - 0.086 12.5 0.2 0.34 10.6 0.0 2.0 2 0 0 2 2 2 0 SSXT protein (N-terminal region) COesterase PF00135.28 CDW55873.1 - 8e-243 806.9 0.5 1.7e-126 423.1 0.0 2.5 2 1 1 3 3 3 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW55873.1 - 1.7e-18 67.2 4.1 4.1e-09 36.6 0.0 3.3 3 1 0 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDW55873.1 - 9.2e-06 25.3 0.2 0.054 13.0 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CDW55873.1 - 0.0064 15.8 0.8 0.71 9.1 0.0 2.5 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 CDW55873.1 - 0.025 13.5 0.4 7.2 5.3 0.0 2.8 2 1 0 2 2 2 0 Steryl acetyl hydrolase PAF-AH_p_II PF03403.13 CDW55873.1 - 0.058 11.9 0.0 3.6 6.0 0.0 2.3 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Collagen PF01391.18 CDW55874.1 - 0.88 9.4 11.3 1.5 8.7 8.1 2.4 2 1 0 2 2 2 0 Collagen triple helix repeat (20 copies) ABC_membrane PF00664.23 CDW55875.1 - 2.6e-13 50.2 10.4 3.5e-13 49.9 10.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region zf-C2H2 PF00096.26 CDW55876.1 - 9.8e-15 54.1 34.5 0.00014 22.1 1.5 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW55876.1 - 8.6e-14 51.2 27.2 2.1e-05 24.8 0.2 6.1 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW55876.1 - 2.1e-12 46.7 34.5 0.0039 17.9 2.7 5.4 5 0 0 5 5 5 5 C2H2-type zinc finger zf-met PF12874.7 CDW55876.1 - 7.5e-06 26.2 22.5 0.046 14.1 1.0 4.8 5 0 0 5 5 4 4 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 CDW55876.1 - 0.0026 18.0 12.3 0.047 14.0 2.8 3.2 2 2 1 3 3 3 2 C2H2-type zinc ribbon GAGA PF09237.11 CDW55876.1 - 0.0027 17.5 0.9 0.017 14.9 0.1 2.3 1 1 1 2 2 2 1 GAGA factor zf-MYST PF17772.1 CDW55876.1 - 0.0029 17.2 13.6 3.4 7.3 0.3 4.9 3 1 2 5 5 5 2 MYST family zinc finger domain zf-C2H2_6 PF13912.6 CDW55876.1 - 0.013 15.5 1.8 0.013 15.5 1.8 5.6 5 1 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW55876.1 - 0.015 15.5 19.8 1.7 9.1 0.7 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-FPG_IleRS PF06827.14 CDW55876.1 - 0.085 12.7 0.3 0.085 12.7 0.3 3.5 4 0 0 4 4 3 0 Zinc finger found in FPG and IleRS zf-H2C2_5 PF13909.6 CDW55876.1 - 0.086 12.6 11.6 0.13 12.1 2.9 4.3 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-Di19 PF05605.12 CDW55876.1 - 0.41 11.0 19.0 0.22 11.9 1.6 3.3 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CDW55876.1 - 0.6 10.5 22.5 16 5.9 0.2 5.1 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-met2 PF12907.7 CDW55876.1 - 1.5 9.0 12.9 0.41 10.8 0.4 3.9 4 0 0 4 4 4 0 Zinc-binding zf-C2H2_9 PF16293.5 CDW55876.1 - 3.6 7.5 11.6 50 3.8 0.1 4.8 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) zf-C2H2_11 PF16622.5 CDW55876.1 - 6.4 6.6 11.4 26 4.7 0.9 3.7 4 0 0 4 4 4 0 zinc-finger C2H2-type Peptidase_C12 PF01088.21 CDW55877.1 - 2.2e-54 184.4 0.0 1.2e-49 169.0 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase, family 1 PRP38 PF03371.15 CDW55877.1 - 2e-52 177.6 0.0 3.8e-52 176.7 0.0 1.5 1 0 0 1 1 1 1 PRP38 family UCH_C PF18031.1 CDW55877.1 - 1.4e-19 69.7 1.4 3.6e-19 68.4 1.4 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases CRAL_TRIO PF00650.20 CDW55877.1 - 1.2e-14 54.3 0.0 2.5e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain PriC PF07445.12 CDW55877.1 - 0.11 12.4 0.6 0.18 11.7 0.6 1.3 1 0 0 1 1 1 0 Primosomal replication protein priC Oxysterol_BP PF01237.18 CDW55878.1 - 1.3e-107 359.9 5.7 3.7e-107 358.4 1.7 2.4 2 1 0 2 2 2 1 Oxysterol-binding protein Sporozoite_P67 PF05642.11 CDW55878.1 - 2 6.4 6.6 2.9 5.9 6.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen His_Phos_2 PF00328.22 CDW55879.1 - 1.4e-25 90.4 0.1 2e-23 83.4 0.1 2.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) NDUF_B5 PF09781.9 CDW55879.1 - 0.064 12.8 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit LRR_4 PF12799.7 CDW55880.1 - 5.4e-42 141.1 43.4 1.1e-08 35.2 3.5 7.2 3 2 5 9 9 9 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW55880.1 - 8.5e-25 87.3 22.2 1e-09 38.1 7.0 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 CDW55880.1 - 3.2e-20 71.7 35.0 2.4e-06 27.2 4.9 6.5 3 3 2 6 6 6 5 Leucine rich repeat LRR_6 PF13516.6 CDW55880.1 - 7.1e-10 38.1 21.1 0.84 9.9 0.5 10.0 10 0 0 10 10 10 3 Leucine Rich repeat UB2H PF14814.6 CDW55880.1 - 0.097 12.7 5.7 52 4.0 0.0 5.6 2 1 5 8 8 8 0 Bifunctional transglycosylase second domain LRR_1 PF00560.33 CDW55880.1 - 1.8 9.4 40.5 46 5.1 0.4 10.7 11 1 0 11 11 11 0 Leucine Rich Repeat Med26 PF08711.11 CDW55881.1 - 2e-07 30.9 0.3 4.3e-07 29.9 0.3 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain zf-CCCH PF00642.24 CDW55881.1 - 0.00022 21.1 5.5 0.00068 19.5 5.5 1.8 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDW55881.1 - 0.0038 17.0 8.4 0.0038 17.0 8.4 2.1 2 0 0 2 2 2 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CDW55881.1 - 0.011 15.8 8.1 0.011 15.8 8.1 2.0 3 0 0 3 3 3 0 Zinc finger domain Torus PF16131.5 CDW55881.1 - 0.077 13.7 0.5 0.46 11.2 0.1 2.3 2 0 0 2 2 2 0 Torus domain PSY3 PF16836.5 CDW55881.1 - 0.092 12.2 0.2 0.17 11.4 0.2 1.3 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description DIM1 PF02966.16 CDW55882.1 - 8.2e-68 226.3 0.1 9.3e-68 226.1 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CDW55882.1 - 7.5e-06 25.9 0.1 9.1e-06 25.6 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CDW55882.1 - 0.014 15.7 0.2 0.02 15.2 0.2 1.3 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_7 PF13899.6 CDW55882.1 - 0.032 14.4 0.1 0.049 13.8 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like TMEM52 PF14979.6 CDW55883.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Transmembrane 52 Ion_trans PF00520.31 CDW55884.1 - 6.4e-41 140.2 17.3 8.1e-41 139.9 17.3 1.1 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 CDW55884.1 - 1.4e-20 73.5 0.0 3.2e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 CDW55884.1 - 1.3e-11 44.3 6.0 1.3e-11 44.3 6.0 2.0 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 CDW55884.1 - 0.18 10.4 10.9 0.28 9.8 10.9 1.2 1 0 0 1 1 1 0 Polycystin cation channel DUF5362 PF17319.2 CDW55884.1 - 1.2 9.0 4.8 5 7.0 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5362) WAP PF00095.21 CDW55885.1 - 2.6e-39 133.3 53.4 1.3e-08 35.1 5.7 5.1 5 0 0 5 5 5 5 WAP-type (Whey Acidic Protein) 'four-disulfide core' ACI44 PF15270.6 CDW55885.1 - 0.068 13.4 21.9 0.65 10.2 1.7 4.6 4 0 0 4 4 4 0 Metallo-carboxypeptidase inhibitor NAD_Gly3P_dh_C PF07479.14 CDW55887.1 - 3.6e-45 153.7 0.0 6.3e-45 152.9 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 CDW55887.1 - 1.2e-35 122.8 0.4 6.4e-18 65.2 0.1 2.5 1 1 1 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CDW55887.1 - 0.019 15.5 1.2 0.49 11.0 0.1 2.9 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 CDW55887.1 - 0.085 12.7 1.0 0.63 9.9 0.0 2.4 2 0 0 2 2 2 0 Rossmann-like domain GYF_2 PF14237.6 CDW55887.1 - 0.16 11.8 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 GYF domain 2 tRNA-synt_1b PF00579.25 CDW55888.1 - 7.5e-59 199.4 0.0 1.2e-58 198.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) ABC_tran PF00005.27 CDW55888.1 - 1.4e-38 132.5 0.0 5.5e-18 65.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDW55888.1 - 7.5e-12 45.1 4.8 0.00088 18.8 0.2 4.1 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain RLI PF04068.15 CDW55888.1 - 1e-11 44.4 4.0 3e-11 43.0 4.0 1.9 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Fer4 PF00037.27 CDW55888.1 - 5.3e-08 32.4 3.0 5.3e-08 32.4 3.0 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_21 PF13304.6 CDW55888.1 - 8e-08 32.4 9.2 0.54 10.0 0.1 4.3 2 2 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDW55888.1 - 1.4e-06 28.8 0.0 0.012 16.0 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CDW55888.1 - 1.9e-06 28.2 0.1 0.0005 20.4 0.0 3.0 3 0 0 3 3 2 1 AAA domain Fer4_6 PF12837.7 CDW55888.1 - 1.3e-05 25.0 2.3 1.3e-05 25.0 2.3 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Rad17 PF03215.15 CDW55888.1 - 1.4e-05 25.1 0.1 0.019 14.9 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain Fer4_7 PF12838.7 CDW55888.1 - 2.4e-05 24.8 5.5 0.00047 20.7 0.2 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_15 PF13175.6 CDW55888.1 - 3.1e-05 23.9 0.0 0.36 10.5 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 CDW55888.1 - 3.2e-05 23.9 0.2 0.037 13.9 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase NACHT PF05729.12 CDW55888.1 - 3.9e-05 23.6 0.0 0.0055 16.6 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 CDW55888.1 - 4.2e-05 24.0 0.0 0.052 14.0 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDW55888.1 - 0.00042 20.0 0.4 0.79 9.5 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_9 PF13187.6 CDW55888.1 - 0.00053 20.1 12.6 0.0011 19.1 12.6 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDW55888.1 - 0.00065 19.8 12.4 0.0015 18.6 12.4 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_18 PF13238.6 CDW55888.1 - 0.00073 20.1 0.0 3.2 8.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain Fer4_2 PF12797.7 CDW55888.1 - 0.0012 18.8 10.6 0.0038 17.2 1.0 2.7 2 0 0 2 2 2 1 4Fe-4S binding domain RNA_helicase PF00910.22 CDW55888.1 - 0.0022 18.3 0.9 0.74 10.2 0.0 3.1 3 1 0 3 3 2 1 RNA helicase SRP54 PF00448.22 CDW55888.1 - 0.0048 16.5 1.1 0.23 11.1 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_10 PF13237.6 CDW55888.1 - 0.0084 16.2 1.4 0.0084 16.2 1.4 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDW55888.1 - 0.0097 16.8 0.1 0.0097 16.8 0.1 2.5 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain AAA_5 PF07728.14 CDW55888.1 - 0.013 15.5 0.8 0.24 11.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.17 CDW55888.1 - 0.013 15.2 0.0 7.4 6.2 0.0 3.0 3 0 0 3 3 2 0 Thymidylate kinase AAA_28 PF13521.6 CDW55888.1 - 0.02 15.2 0.4 1.8 8.8 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDW55888.1 - 0.022 14.5 0.9 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDW55888.1 - 0.025 14.6 0.4 3.7 7.6 0.0 3.4 3 1 1 4 4 4 0 AAA domain AAA_33 PF13671.6 CDW55888.1 - 0.028 14.6 0.0 10 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 CDW55888.1 - 0.03 14.0 0.2 0.74 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDW55888.1 - 0.03 13.8 0.0 0.46 10.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region TsaE PF02367.17 CDW55888.1 - 0.034 14.1 0.2 0.44 10.5 0.0 2.7 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 CDW55888.1 - 0.048 13.7 0.7 5.8 7.0 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 CDW55888.1 - 0.073 13.6 7.9 0.13 12.7 0.4 2.8 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CDW55888.1 - 0.13 11.4 0.0 17 4.5 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain dNK PF01712.19 CDW55888.1 - 0.19 11.6 0.4 59 3.4 0.0 3.2 3 0 0 3 3 3 0 Deoxynucleoside kinase Roc PF08477.13 CDW55888.1 - 0.3 11.3 0.9 0.99 9.6 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase tRNA-synt_1f PF01921.18 CDW55888.1 - 0.49 9.3 1.5 0.75 8.7 0.5 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (K) NTPase_1 PF03266.15 CDW55888.1 - 0.75 9.7 4.2 4.8 7.1 0.1 3.3 3 0 0 3 3 3 0 NTPase Fer4_4 PF12800.7 CDW55888.1 - 0.97 10.1 17.0 0.33 11.6 2.9 2.9 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.7 CDW55888.1 - 1.5 9.9 17.5 0.099 13.6 4.8 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 CDW55888.1 - 2.1 8.9 11.9 0.15 12.6 1.9 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDW55888.1 - 5.6 7.5 11.4 0.67 10.4 1.4 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain WD40 PF00400.32 CDW55889.1 - 4.2e-20 71.7 15.5 5.1e-09 36.6 0.1 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 CDW55889.1 - 1.8e-17 63.8 0.0 3.2e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 CDW55889.1 - 1.5e-07 31.6 0.0 0.51 10.7 0.0 4.9 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW55889.1 - 0.00086 18.1 0.0 0.0027 16.4 0.0 1.7 2 0 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 CDW55889.1 - 0.046 13.0 0.0 9.3 5.5 0.0 2.9 2 1 1 3 3 3 0 WD40-like domain 7tm_1 PF00001.21 CDW55890.1 - 9.6e-50 169.3 22.5 9.6e-50 169.3 22.5 2.0 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW55890.1 - 1.5e-07 31.1 24.3 1.9e-06 27.5 24.3 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 CDW55890.1 - 8.6e-06 25.7 11.5 8.6e-06 25.7 11.5 2.1 2 1 0 2 2 2 1 Olfactory receptor T3SS_needle_F PF09392.10 CDW55890.1 - 0.2 11.9 1.6 0.37 11.0 1.6 1.4 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF DUF4577 PF15145.6 CDW55890.1 - 2.6 8.1 4.1 0.84 9.7 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) 7TM_GPCR_Srx PF10328.9 CDW55890.1 - 4.2 6.9 28.8 0.027 14.1 16.4 2.6 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx Nodulin_late PF07127.11 CDW55891.1 - 0.0042 17.4 5.7 0.0049 17.2 0.1 2.3 2 1 0 2 2 2 1 Late nodulin protein Stig1 PF04885.13 CDW55891.1 - 0.005 17.3 2.2 0.006 17.1 2.2 1.1 1 0 0 1 1 1 1 Stigma-specific protein, Stig1 EB PF01683.18 CDW55891.1 - 0.057 13.7 7.1 0.057 13.7 7.1 1.8 1 1 1 2 2 2 0 EB module Dickkopf_N PF04706.12 CDW55891.1 - 0.21 12.1 13.9 4 8.0 14.4 2.1 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Ufm1 PF03671.14 CDW55892.1 - 6.3e-30 103.1 0.0 7.5e-30 102.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Glyco_transf_20 PF00982.21 CDW55893.1 - 1.6e-82 277.7 0.0 8.9e-81 271.9 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase family 20 T6PP_N PF18572.1 CDW55893.1 - 2.6e-33 113.8 0.0 5.2e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Hydrolase_3 PF08282.12 CDW55893.1 - 0.19 11.4 0.0 0.48 10.1 0.0 1.6 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Pkinase PF00069.25 CDW55895.1 - 4.6e-62 209.8 0.0 5.6e-62 209.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55895.1 - 2.5e-30 105.6 0.0 3.9e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW55895.1 - 0.00062 19.2 0.0 0.0027 17.1 0.0 1.9 3 0 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 CDW55895.1 - 0.014 14.1 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 CDW55895.1 - 0.018 14.0 0.0 0.027 13.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CDW55895.1 - 0.018 15.0 0.4 0.075 12.9 0.1 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Histone PF00125.24 CDW55896.1 - 1e-19 71.2 0.2 1.2e-19 70.9 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW55896.1 - 0.00013 22.2 0.0 0.00028 21.1 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW55896.1 - 0.018 15.1 0.2 0.022 14.8 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein DUF4518 PF15008.6 CDW55896.1 - 0.026 13.7 0.0 0.029 13.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) TAF PF02969.17 CDW55896.1 - 0.061 13.5 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) CENP-T_C PF15511.6 CDW55896.1 - 0.066 13.3 0.1 0.11 12.6 0.1 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold AAA PF00004.29 CDW55897.1 - 2.2e-45 154.3 0.0 7e-45 152.7 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW55897.1 - 2.4e-10 40.0 0.1 5e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 CDW55897.1 - 7.4e-08 32.7 0.0 1.8e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CDW55897.1 - 2.3e-07 30.9 0.1 1.4e-06 28.3 0.0 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW55897.1 - 3.5e-07 30.7 0.0 0.00037 20.9 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CDW55897.1 - 1.2e-06 28.4 0.0 3.4e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDW55897.1 - 6.5e-06 26.5 0.5 0.013 15.7 0.0 2.6 1 1 1 2 2 2 2 AAA domain Prot_ATP_ID_OB PF16450.5 CDW55897.1 - 9.6e-06 25.5 2.5 1.1e-05 25.3 0.2 2.4 3 0 0 3 3 2 1 Proteasomal ATPase OB C-terminal domain AAA_7 PF12775.7 CDW55897.1 - 4.1e-05 23.2 0.0 8.9e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 CDW55897.1 - 0.00018 21.5 0.1 0.0086 16.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CDW55897.1 - 0.00048 20.5 0.1 0.0044 17.4 0.0 2.4 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 CDW55897.1 - 0.0005 19.3 0.0 0.00098 18.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 CDW55897.1 - 0.0016 17.7 0.0 0.0038 16.5 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 CDW55897.1 - 0.002 18.7 0.0 0.0058 17.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDW55897.1 - 0.0041 16.5 0.0 0.0083 15.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CDW55897.1 - 0.012 15.3 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 CDW55897.1 - 0.014 15.2 0.0 0.034 14.0 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SKI PF01202.22 CDW55897.1 - 0.016 15.3 0.7 0.18 11.9 0.0 2.7 3 1 0 3 3 2 0 Shikimate kinase AAA_33 PF13671.6 CDW55897.1 - 0.017 15.3 0.0 0.037 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW55897.1 - 0.018 14.8 0.4 0.068 12.9 0.1 2.1 2 1 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CDW55897.1 - 0.024 14.4 0.1 0.068 12.9 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase TsaE PF02367.17 CDW55897.1 - 0.025 14.6 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 CDW55897.1 - 0.026 13.9 1.9 0.19 11.1 0.1 2.9 2 1 1 3 3 3 0 KaiC AFG1_ATPase PF03969.16 CDW55897.1 - 0.027 13.4 0.0 1.3 7.8 0.0 2.2 2 0 0 2 2 2 0 AFG1-like ATPase Sigma54_activat PF00158.26 CDW55897.1 - 0.035 13.8 0.0 0.19 11.4 0.0 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 CDW55897.1 - 0.049 13.5 0.1 1.8 8.4 0.0 2.3 1 1 1 2 2 2 0 NACHT domain AAA_11 PF13086.6 CDW55897.1 - 0.059 13.2 0.0 0.18 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 CDW55897.1 - 0.067 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 CDW55897.1 - 0.071 13.5 0.0 0.21 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDW55897.1 - 0.1 12.5 3.3 1.7 8.5 0.1 3.3 4 1 0 4 4 3 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 CDW55897.1 - 0.15 12.5 0.9 0.72 10.3 0.1 2.5 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDW55897.1 - 0.17 12.1 0.1 0.53 10.5 0.0 1.9 2 0 0 2 2 1 0 AAA domain RRM_1 PF00076.22 CDW55898.1 - 3.8e-29 100.3 2.2 1.9e-14 53.2 0.1 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW55898.1 - 3.9e-09 36.2 0.1 0.00058 19.5 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW55898.1 - 3.6e-06 26.7 0.1 0.032 14.1 0.0 2.2 2 0 0 2 2 2 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CDW55898.1 - 0.044 13.8 0.1 14 5.8 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 CDW55898.1 - 0.054 13.3 0.0 0.14 12.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) PHM7_cyt PF14703.6 CDW55898.1 - 0.063 13.5 1.5 7.9 6.7 0.1 2.6 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter HCO3_cotransp PF00955.21 CDW55899.1 - 1.1e-167 558.9 29.5 1.2e-145 486.2 24.2 3.1 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.13 CDW55899.1 - 1.1e-30 107.4 0.0 2e-30 106.6 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Band_3_cyto PF07565.13 CDW55900.1 - 3.1e-10 40.3 0.1 4.1e-10 39.9 0.1 1.1 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Bromodomain PF00439.25 CDW55901.1 - 2.2e-09 37.3 0.0 5.3e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Bromodomain ANAPC2 PF08672.11 CDW55902.1 - 0.012 16.1 3.4 0.055 14.0 0.9 2.6 2 1 0 2 2 2 0 Anaphase promoting complex (APC) subunit 2 CtsR_C PF17727.1 CDW55902.1 - 0.03 14.4 0.5 0.069 13.3 0.5 1.7 1 0 0 1 1 1 0 CtsR C-terminal dimerization domain Nitr_red_bet_C PF14711.6 CDW55902.1 - 0.081 12.6 0.1 0.23 11.2 0.1 1.8 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal Milton PF12448.8 CDW55902.1 - 0.088 12.9 0.9 0.14 12.2 0.6 1.5 1 1 0 1 1 1 0 Kinesin associated protein ANAPC2 PF08672.11 CDW55903.1 - 0.007 16.9 2.2 0.044 14.3 0.6 2.4 2 0 0 2 2 2 1 Anaphase promoting complex (APC) subunit 2 CtsR_C PF17727.1 CDW55903.1 - 0.032 14.4 0.5 0.073 13.2 0.5 1.6 1 0 0 1 1 1 0 CtsR C-terminal dimerization domain Milton PF12448.8 CDW55903.1 - 0.041 14.0 0.8 0.075 13.1 0.5 1.5 1 1 0 1 1 1 0 Kinesin associated protein DUF1840 PF08895.11 CDW55903.1 - 0.21 11.9 4.1 0.92 9.9 4.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) Peptidase_M10 PF00413.24 CDW55904.1 - 2.9e-51 173.5 1.5 6.4e-51 172.3 0.1 2.2 3 0 0 3 3 3 1 Matrixin Hemopexin PF00045.19 CDW55904.1 - 6.1e-40 134.9 16.3 1.4e-12 47.3 0.2 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 CDW55904.1 - 1.8e-09 37.7 0.1 9.2e-09 35.4 0.0 2.2 2 1 0 2 2 2 1 Putative peptidoglycan binding domain Reprolysin_4 PF13583.6 CDW55904.1 - 0.0002 21.0 0.1 0.00039 20.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 CDW55904.1 - 0.00045 19.9 0.2 0.55 9.8 0.1 2.3 2 0 0 2 2 2 2 Astacin (Peptidase family M12A) DUF4953 PF16313.5 CDW55904.1 - 0.00052 19.3 0.2 0.00093 18.5 0.2 1.3 1 0 0 1 1 1 1 Met-zincin Reprolysin_3 PF13582.6 CDW55904.1 - 0.0022 18.5 0.0 0.0042 17.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CDW55904.1 - 0.013 15.7 0.2 0.024 14.8 0.2 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M57 PF12388.8 CDW55904.1 - 0.21 11.2 0.6 0.49 10.0 0.2 1.9 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase RRM_1 PF00076.22 CDW55905.1 - 9.7e-21 73.4 0.0 3.5e-10 39.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KxDL PF10241.9 CDW55905.1 - 5.2e-11 42.7 1.4 1.3e-10 41.4 1.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein RRM_7 PF16367.5 CDW55905.1 - 0.11 12.6 0.0 26 5.0 0.0 3.1 3 0 0 3 3 3 0 RNA recognition motif Cnn_1N PF07989.11 CDW55906.1 - 0.0085 16.2 3.8 0.0085 16.2 3.8 5.0 3 1 2 5 5 5 2 Centrosomin N-terminal motif 1 Rx_N PF18052.1 CDW55906.1 - 0.7 10.2 5.3 0.47 10.8 0.2 3.0 3 0 0 3 3 3 0 Rx N-terminal domain Histone PF00125.24 CDW55907.1 - 7.9e-54 181.5 1.5 8.7e-54 181.4 1.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW55907.1 - 0.00015 22.3 2.4 0.00019 22.0 2.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW55907.1 - 0.0002 21.4 0.2 0.00042 20.4 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW55907.1 - 0.00028 21.2 0.0 0.00042 20.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW55907.1 - 0.0043 17.3 0.0 0.0083 16.4 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDW55907.1 - 0.06 13.4 0.1 0.11 12.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit SNARE PF05739.19 CDW55908.1 - 3.9e-07 30.0 0.2 1e-06 28.6 0.2 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin-18_N PF10496.9 CDW55908.1 - 0.0032 17.7 0.1 0.014 15.6 0.1 2.2 1 0 0 1 1 1 1 SNARE-complex protein Syntaxin-18 N-terminus Trypsin PF00089.26 CDW55908.1 - 0.074 12.8 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Trypsin TMPIT PF07851.13 CDW55908.1 - 0.69 9.1 5.4 10 5.3 0.1 2.4 2 0 0 2 2 2 0 TMPIT-like protein BRE1 PF08647.11 CDW55908.1 - 2.4 8.3 8.7 13 6.0 7.0 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase KH_9 PF17904.1 CDW55909.1 - 3e-21 75.6 0.4 6.6e-21 74.5 0.0 1.7 2 0 0 2 2 2 1 FMRP KH0 domain KH_1 PF00013.29 CDW55909.1 - 2.6e-19 68.8 0.1 1.1e-10 41.1 0.1 2.9 3 0 0 3 3 3 2 KH domain FXMRP1_C_core PF12235.8 CDW55909.1 - 1e-09 39.2 1.6 1.7e-09 38.5 1.6 1.3 1 0 0 1 1 1 1 Fragile X-related 1 protein core C terminal Tudor_FRX1 PF18336.1 CDW55909.1 - 5.6e-05 23.0 0.0 0.00013 21.8 0.0 1.7 1 0 0 1 1 1 1 Fragile X mental retardation Tudor domain KH_2 PF07650.17 CDW55909.1 - 0.00062 19.5 2.4 0.64 9.9 1.6 2.6 1 1 0 2 2 2 2 KH domain KH_5 PF13184.6 CDW55909.1 - 0.12 12.5 0.5 1.4 9.0 0.5 2.4 2 0 0 2 2 2 0 NusA-like KH domain PCB_OB PF17092.5 CDW55909.1 - 0.15 12.9 0.3 3 8.6 0.0 2.6 2 1 0 2 2 2 0 Penicillin-binding protein OB-like domain Myosin_N PF02736.19 CDW55909.1 - 0.51 10.2 2.7 6.8 6.6 0.0 2.9 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain KH_4 PF13083.6 CDW55909.1 - 0.7 9.8 5.2 2.3 8.1 1.1 3.2 2 2 1 3 3 3 0 KH domain SH3_2 PF07653.17 CDW55909.1 - 0.88 9.3 0.0 0.88 9.3 0.0 2.3 2 0 0 2 2 2 0 Variant SH3 domain Pkinase PF00069.25 CDW55910.1 - 4.2e-74 249.2 0.0 6.9e-74 248.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55910.1 - 6.4e-47 160.0 0.0 9.3e-47 159.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CDW55910.1 - 3.1e-22 78.7 0.0 6.8e-22 77.6 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 CDW55910.1 - 4.5e-08 32.8 0.0 7.9e-06 25.4 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CDW55910.1 - 2.2e-06 26.7 0.0 3.3e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW55910.1 - 0.0041 17.1 0.0 0.48 10.3 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDW55910.1 - 0.0097 15.3 0.1 0.033 13.5 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DSHCT PF08148.12 CDW55910.1 - 0.033 13.9 0.0 0.069 12.8 0.0 1.6 1 0 0 1 1 1 0 DSHCT (NUC185) domain Haspin_kinase PF12330.8 CDW55910.1 - 0.056 12.4 0.2 0.27 10.1 0.2 1.9 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 CDW55910.1 - 0.11 12.2 0.4 0.48 10.0 0.0 2.1 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Sec1 PF00995.23 CDW55911.1 - 2.1e-121 407.0 0.1 2.3e-121 406.8 0.1 1.0 1 0 0 1 1 1 1 Sec1 family BLOC1_2 PF10046.9 CDW55911.1 - 0.059 13.7 1.0 0.91 9.9 0.7 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0184 PF03670.13 CDW55912.1 - 2.8e-05 24.4 5.6 2.8e-05 24.4 5.6 2.1 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0184) Muted PF14942.6 CDW55912.1 - 0.00035 20.9 6.1 0.00047 20.5 6.1 1.2 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein APG6_N PF17675.1 CDW55912.1 - 0.0063 17.0 8.2 0.0071 16.9 8.2 1.1 1 0 0 1 1 1 1 Apg6 coiled-coil region BLOC1_2 PF10046.9 CDW55912.1 - 0.0069 16.7 1.3 0.0083 16.4 0.1 1.7 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0242 PF06785.11 CDW55912.1 - 0.016 15.3 8.2 0.019 15.1 8.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Herpes_UL6 PF01763.16 CDW55912.1 - 0.037 12.6 3.4 0.041 12.4 3.4 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like MitMem_reg PF13012.6 CDW55912.1 - 0.095 13.1 1.7 0.16 12.4 1.7 1.3 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function CREPT PF16566.5 CDW55912.1 - 0.11 12.6 5.5 0.15 12.3 5.5 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour ALMT PF11744.8 CDW55912.1 - 0.12 11.2 3.7 0.14 10.9 3.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CENP-H PF05837.12 CDW55912.1 - 0.12 12.7 7.1 0.22 11.9 7.1 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4140 PF13600.6 CDW55912.1 - 0.13 12.8 0.1 0.13 12.8 0.1 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF724 PF05266.14 CDW55912.1 - 0.13 12.0 5.4 0.19 11.6 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Exonuc_VII_L PF02601.15 CDW55912.1 - 0.14 11.7 7.2 0.15 11.6 7.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit ING PF12998.7 CDW55912.1 - 0.28 11.8 5.5 0.56 10.8 5.5 1.5 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Atg14 PF10186.9 CDW55912.1 - 0.28 10.2 7.1 0.36 9.9 7.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 CDW55912.1 - 0.43 8.4 5.1 0.45 8.4 5.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Snf7 PF03357.21 CDW55912.1 - 0.43 10.1 9.1 0.59 9.7 9.1 1.2 1 0 0 1 1 1 0 Snf7 DUF4200 PF13863.6 CDW55912.1 - 0.45 10.9 16.1 0.69 10.3 0.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) LMBR1 PF04791.16 CDW55912.1 - 1.1 8.0 3.8 1.3 7.9 3.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF5320 PF17253.2 CDW55912.1 - 1.5 10.0 4.7 3.3 8.8 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF4407 PF14362.6 CDW55912.1 - 1.8 7.8 10.4 7.4 5.8 10.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1635 PF07795.11 CDW55912.1 - 7.7 6.3 9.7 16 5.3 7.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) TSP_1 PF00090.19 CDW55913.1 - 4.9 7.5 30.0 0.047 13.9 5.1 3.9 4 0 0 4 4 4 0 Thrombospondin type 1 domain DUF1977 PF09320.11 CDW55914.1 - 4.9e-27 94.3 1.2 4.9e-27 94.3 1.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 CDW55914.1 - 1.6e-24 85.8 0.3 4e-24 84.5 0.3 1.7 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 CDW55914.1 - 0.084 13.0 0.3 0.56 10.4 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW55914.1 - 0.12 12.6 0.2 0.45 10.8 0.2 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TFIIS_C PF01096.18 CDW55915.1 - 2e-15 56.3 2.4 2e-15 56.3 2.4 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Baculo_LEF5_C PF11792.8 CDW55915.1 - 0.0012 18.4 1.5 0.0032 17.1 1.5 1.7 1 0 0 1 1 1 1 Baculoviridae late expression factor 5 C-terminal domain TF_Zn_Ribbon PF08271.12 CDW55915.1 - 0.014 14.9 10.6 0.015 14.8 1.1 3.1 2 1 0 2 2 2 0 TFIIB zinc-binding DZR PF12773.7 CDW55915.1 - 0.094 12.8 9.4 1.4 9.0 0.6 2.9 2 1 1 3 3 3 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 CDW55915.1 - 2.5 7.9 10.5 7.3 6.5 0.0 3.7 4 0 0 4 4 4 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 CDW55915.1 - 6.1 6.9 6.6 0.5 10.4 1.0 2.2 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zinc_ribbon_4 PF13717.6 CDW55915.1 - 6.5 6.8 7.7 23 5.0 0.5 3.4 3 0 0 3 3 3 0 zinc-ribbon domain IBR PF01485.21 CDW55915.1 - 6.6 7.0 11.4 1.3 9.3 1.8 2.6 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-ribbon_3 PF13248.6 CDW55915.1 - 6.8 6.3 10.8 4.6 6.8 2.3 3.5 3 1 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 CDW55915.1 - 7.9 6.5 10.0 5.7 7.0 0.9 2.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain MgtE PF01769.16 CDW55916.1 - 1.4e-45 154.7 25.8 2.3e-25 89.4 1.7 3.1 2 1 1 3 3 3 3 Divalent cation transporter UQ_con PF00179.26 CDW55918.1 - 1.1e-52 177.5 0.0 1.2e-52 177.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDW55918.1 - 0.014 15.6 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 CDW55918.1 - 0.031 14.0 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 CDW55918.1 - 0.083 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain Proteasome PF00227.26 CDW55919.1 - 3.9e-55 186.3 0.2 4.8e-55 186.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDW55919.1 - 7e-14 51.2 0.0 1.2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ribosomal_L15e PF00827.17 CDW55920.1 - 1.6e-93 311.8 9.0 1.8e-93 311.6 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 zf-C3HC4_3 PF13920.6 CDW55921.1 - 0.00061 19.6 17.0 0.00061 19.6 17.0 3.8 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Ly-6_related PF06579.12 CDW55922.1 - 1e-26 93.6 1.9 1.5e-26 93.1 1.9 1.2 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein QVR PF17064.5 CDW55922.1 - 0.0059 16.8 5.9 0.22 11.8 0.8 2.8 2 1 0 2 2 2 2 Sleepless protein TB2_DP1_HVA22 PF03134.19 CDW55924.1 - 2.3e-24 85.1 3.1 2.3e-24 85.1 3.1 1.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family ABC_membrane_2 PF06472.15 CDW55925.1 - 8.6e-50 169.6 3.4 2.1e-43 148.7 1.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CDW55925.1 - 1.2e-09 38.8 0.0 1.2e-08 35.6 0.0 2.2 1 1 0 1 1 1 1 ABC transporter ATP-synt_ab PF00006.25 CDW55925.1 - 0.012 15.3 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_16 PF13191.6 CDW55925.1 - 0.015 15.7 0.0 0.077 13.4 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Clathrin PF00637.20 CDW55926.1 - 1.5e-17 63.8 0.2 2.3e-16 60.0 0.1 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS zf-RING_5 PF14634.6 CDW55926.1 - 0.0001 22.2 9.0 0.00029 20.7 9.0 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CDW55926.1 - 0.00024 21.3 8.8 0.00024 21.3 8.8 2.4 3 0 0 3 3 1 1 Ring finger domain Vps39_2 PF10367.9 CDW55926.1 - 0.00095 19.6 2.6 0.00095 19.6 2.6 2.1 1 1 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.6 CDW55926.1 - 0.0013 18.5 7.8 0.0042 16.9 7.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDW55926.1 - 0.0016 18.1 6.5 0.0016 18.1 6.5 2.3 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 CDW55926.1 - 0.0024 18.1 8.3 0.0095 16.2 8.3 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDW55926.1 - 0.02 14.9 8.8 0.05 13.6 8.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW55926.1 - 0.021 14.7 6.1 0.058 13.3 6.1 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW55926.1 - 0.052 13.4 9.2 0.13 12.1 9.2 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WD40_like PF17005.5 CDW55926.1 - 0.1 11.9 0.0 0.24 10.7 0.0 1.6 1 0 0 1 1 1 0 WD40-like domain ANAPC4_WD40 PF12894.7 CDW55926.1 - 0.14 12.5 0.0 11 6.3 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_9 PF13901.6 CDW55926.1 - 0.32 10.9 12.9 1.4 8.8 12.9 2.1 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-C3H2C3 PF17122.5 CDW55926.1 - 0.39 10.8 12.5 0.052 13.6 7.9 2.1 2 0 0 2 2 1 0 Zinc-finger WD40 PF00400.32 CDW55926.1 - 2.5 9.1 5.1 2.8 9.0 0.1 3.7 5 0 0 5 5 3 0 WD domain, G-beta repeat InaF-motif PF15018.6 CDW55927.1 - 1.3e-17 63.3 3.9 2.2e-17 62.7 3.9 1.4 1 0 0 1 1 1 1 TRP-interacting helix Tfb4 PF03850.14 CDW55927.1 - 0.17 11.3 0.4 0.2 11.1 0.4 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 zf-C3HC4 PF00097.25 CDW55928.1 - 0.0019 18.0 6.2 0.0036 17.1 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDW55928.1 - 0.0028 17.4 2.8 0.0028 17.4 2.8 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CDW55928.1 - 0.027 14.3 4.7 0.048 13.5 4.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW55928.1 - 0.61 10.5 6.0 1.1 9.6 6.0 1.5 1 0 0 1 1 1 0 Ring finger domain IRF-2BP1_2 PF11261.8 CDW55929.1 - 1.7e-34 117.2 1.3 2.4e-34 116.7 1.3 1.2 1 0 0 1 1 1 1 Interferon regulatory factor 2-binding protein zinc finger Gal-bind_lectin PF00337.22 CDW55930.1 - 7.9e-35 119.3 0.0 1.1e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Galactoside-binding lectin MGTL PF17059.5 CDW55930.1 - 0.13 12.1 0.1 0.13 12.1 0.1 2.3 2 0 0 2 2 2 0 MgtA leader peptide TTR-52 PF01060.23 CDW55931.1 - 2.2e-19 70.0 0.1 2.6e-19 69.7 0.1 1.1 1 0 0 1 1 1 1 Transthyretin-like family Globin PF00042.22 CDW55932.1 - 0.00056 20.5 0.0 0.003 18.1 0.0 2.0 1 1 1 2 2 2 2 Globin Alfin PF12165.8 CDW55932.1 - 0.099 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Alfin TGT PF01702.18 CDW55933.1 - 2.8e-63 214.2 0.0 3.3e-63 213.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase GBP PF02263.19 CDW55934.1 - 2.1e-48 164.9 0.4 2.2e-47 161.5 0.4 2.0 1 1 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 CDW55934.1 - 0.00086 18.8 0.1 0.0013 18.3 0.1 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 CDW55934.1 - 0.069 13.6 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 T-lymphoma invasion and metastasis CC-Ex domain PID PF00640.23 CDW55935.1 - 1.5e-20 73.7 0.3 9.5e-20 71.1 0.3 2.3 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) NumbF PF06311.12 CDW55935.1 - 9.2e-08 32.5 0.1 2.7e-07 31.1 0.1 1.8 1 0 0 1 1 1 1 NUMB domain PID_2 PF14719.6 CDW55935.1 - 0.035 14.0 0.4 0.58 10.0 0.4 2.3 1 1 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) HAGH_C PF16123.5 CDW55936.1 - 1.1e-21 77.1 0.1 2.1e-20 73.0 0.1 2.5 2 0 0 2 2 2 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CDW55936.1 - 2.7e-11 43.9 2.9 2.2e-09 37.6 2.9 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily zf-CCCH PF00642.24 CDW55936.1 - 3.3e-07 30.0 12.5 2.1e-05 24.3 0.2 3.5 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CDW55936.1 - 8e-06 25.7 1.2 8e-06 25.7 1.2 3.8 4 0 0 4 4 4 2 Zinc finger domain Torus PF16131.5 CDW55936.1 - 1.7e-05 25.4 0.9 0.0017 19.0 0.1 2.5 2 0 0 2 2 2 1 Torus domain zf-CCCH_4 PF18044.1 CDW55936.1 - 1.8e-05 24.4 16.0 0.002 17.9 0.9 3.9 3 0 0 3 3 3 2 CCCH-type zinc finger zf-C3HC4 PF00097.25 CDW55936.1 - 5.5e-05 23.0 14.7 5.5e-05 23.0 14.7 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW55936.1 - 5.5e-05 23.4 15.8 5.5e-05 23.4 15.8 3.6 4 0 0 4 4 2 1 Ring finger domain Lactamase_B_2 PF12706.7 CDW55936.1 - 0.0016 18.0 1.2 0.012 15.1 1.2 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain zf-rbx1 PF12678.7 CDW55936.1 - 0.0018 18.5 10.4 0.012 15.9 10.4 2.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain Lactamase_B_3 PF13483.6 CDW55936.1 - 0.0028 17.5 0.2 0.0066 16.4 0.2 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain BcrAD_BadFG PF01869.20 CDW55936.1 - 0.014 15.0 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DUF4124 PF13511.6 CDW55936.1 - 0.058 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) Baculo_RING PF05883.11 CDW55936.1 - 0.13 12.2 4.9 0.37 10.8 4.9 1.8 1 1 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-RING_11 PF17123.5 CDW55936.1 - 2.5 7.9 13.6 6.1 6.7 10.3 3.4 3 0 0 3 3 3 0 RING-like zinc finger Med4 PF10018.9 CDW55937.1 - 1.7e-15 57.2 0.0 2.4e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 Med11 PF10280.9 CDW55939.1 - 2.7e-11 44.1 0.6 3.1e-11 43.9 0.6 1.1 1 0 0 1 1 1 1 Mediator complex protein MtrG PF04210.13 CDW55939.1 - 0.025 14.4 0.6 6.9 6.6 0.0 2.9 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G RYDR_ITPR PF01365.21 CDW55939.1 - 0.033 13.6 0.1 0.039 13.4 0.1 1.2 1 0 0 1 1 1 0 RIH domain Collagen_mid PF15984.5 CDW55939.1 - 0.1 12.4 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Bacterial collagen, middle region HSBP1 PF06825.12 CDW55939.1 - 0.12 12.2 0.1 3.7 7.5 0.0 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 DUF745 PF05335.13 CDW55941.1 - 0.0075 16.0 0.3 0.0087 15.8 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF745) RRM_1 PF00076.22 CDW55942.1 - 2.5e-09 36.8 0.1 4.7e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW55942.1 - 0.0029 17.7 0.0 0.0047 17.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif Rrp15p PF07890.12 CDW55943.1 - 0.21 11.9 0.5 0.21 11.9 0.5 1.9 2 0 0 2 2 2 0 Rrp15p BLOC1S3 PF15753.5 CDW55944.1 - 9.3 6.3 8.5 8.9 6.4 5.1 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 MAP7 PF05672.11 CDW55945.1 - 9.1e-08 32.0 53.8 9.1e-08 32.0 53.8 3.2 4 0 0 4 4 4 1 MAP7 (E-MAP-115) family ABC_tran PF00005.27 CDW55948.1 - 4.1e-43 147.2 0.0 1.2e-24 87.4 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDW55948.1 - 8.7e-17 61.9 0.1 9e-08 32.3 0.0 3.6 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 CDW55948.1 - 0.00063 19.0 9.5 0.00063 19.0 9.5 2.7 3 0 0 3 3 3 1 ABC-2 family transporter protein DUF2868 PF11067.8 CDW55948.1 - 0.013 15.0 2.5 0.023 14.2 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) AAA_23 PF13476.6 CDW55948.1 - 0.022 15.3 0.3 0.065 13.7 0.3 1.8 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CDW55948.1 - 0.039 13.4 0.2 3.4 7.0 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDW55948.1 - 0.13 12.7 0.0 0.4 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 CDW55948.1 - 0.15 11.8 0.2 23 4.7 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Patched PF02460.18 CDW55949.1 - 2.6e-221 737.0 7.3 3.1e-221 736.7 7.3 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW55949.1 - 1.7e-35 122.1 7.7 1.7e-35 122.1 7.7 3.0 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 CDW55949.1 - 9.6e-08 30.2 2.7 1.6e-07 29.5 2.7 1.2 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family AGTRAP PF06396.11 CDW55949.1 - 0.34 10.7 3.7 0.2 11.5 0.3 2.3 2 0 0 2 2 2 0 Angiotensin II, type I receptor-associated protein (AGTRAP) Ig_mannosidase PF17753.1 CDW55950.1 - 1.5e-16 59.9 1.0 4.7e-16 58.3 1.0 1.9 1 0 0 1 1 1 1 Ig-fold domain CRIC_ras_sig PF10534.9 CDW55950.1 - 7.5e-15 54.9 0.7 1.6e-14 53.8 0.7 1.6 1 0 0 1 1 1 1 Connector enhancer of kinase suppressor of ras SAM_2 PF07647.17 CDW55950.1 - 9.7e-09 35.2 0.0 2.2e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CDW55950.1 - 1.3e-08 35.1 0.0 2.7e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 CDW55950.1 - 4.9e-07 29.5 0.0 2.3e-06 27.4 0.0 2.2 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 CDW55950.1 - 1e-06 29.2 0.1 4e-06 27.3 0.1 2.1 1 0 0 1 1 1 1 PH domain PDZ PF00595.24 CDW55950.1 - 0.00011 22.5 0.0 0.00026 21.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Mannosidase_ig PF17786.1 CDW55950.1 - 0.00093 19.8 0.6 0.007 16.9 0.0 2.7 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_N PF02837.18 CDW55950.1 - 0.02 14.8 0.0 0.078 12.9 0.0 2.0 2 0 0 2 2 2 0 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 CDW55950.1 - 0.033 13.3 0.0 0.056 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain PDZ_2 PF13180.6 CDW55950.1 - 0.1 12.9 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 PDZ domain bZIP_1 PF00170.21 CDW55952.1 - 6.6e-18 64.6 16.4 1.2e-17 63.8 16.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CDW55952.1 - 6.3e-07 29.4 15.8 1.3e-06 28.4 15.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CDW55952.1 - 0.0012 19.4 5.7 0.0022 18.5 5.7 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor SR-25 PF10500.9 CDW55952.1 - 0.0066 16.1 4.0 0.0066 16.1 4.0 2.0 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein pKID PF02173.17 CDW55952.1 - 0.031 13.7 0.5 0.08 12.4 0.1 1.9 2 0 0 2 2 2 0 pKID domain Rh5 PF18515.1 CDW55952.1 - 0.039 13.3 2.0 0.054 12.8 2.0 1.2 1 0 0 1 1 1 0 Rh5 coiled-coil domain DUF2992 PF11208.8 CDW55953.1 - 0.71 10.1 6.1 0.18 12.0 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) SprT-like PF10263.9 CDW55954.1 - 6.1e-32 109.8 0.9 1.2e-31 108.9 0.2 1.8 2 0 0 2 2 2 1 SprT-like family WLM PF08325.10 CDW55954.1 - 0.49 10.4 3.2 0.38 10.8 0.2 2.1 2 1 0 2 2 2 0 WLM domain Cadherin PF00028.17 CDW55955.1 - 0 1038.6 0.4 3.5e-21 75.4 0.0 30.5 31 1 0 31 31 30 28 Cadherin domain Laminin_G_2 PF02210.24 CDW55955.1 - 4.5e-21 75.7 0.3 2.4e-20 73.4 0.3 2.4 1 0 0 1 1 1 1 Laminin G domain Cadherin_2 PF08266.12 CDW55955.1 - 1.8e-17 63.0 0.0 3.6 7.5 0.0 13.1 15 0 0 15 15 14 4 Cadherin-like EGF PF00008.27 CDW55955.1 - 1.9e-17 63.2 65.7 4.5e-06 26.9 4.3 6.7 6 0 0 6 6 6 5 EGF-like domain Cadherin_3 PF16184.5 CDW55955.1 - 2.9e-16 59.4 10.1 1.8 8.6 0.0 14.3 14 0 0 14 14 14 4 Cadherin-like Laminin_G_1 PF00054.23 CDW55955.1 - 9.6e-16 58.2 0.0 2.3e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Laminin G domain RET_CLD1 PF17756.1 CDW55955.1 - 7.3e-12 45.7 0.0 3.8 7.8 0.0 11.4 14 0 0 14 14 11 1 RET Cadherin like domain 1 Y_Y_Y PF07495.13 CDW55955.1 - 5.7e-05 23.0 0.0 1.2 9.1 0.0 6.2 5 0 0 5 5 5 1 Y_Y_Y domain hEGF PF12661.7 CDW55955.1 - 0.031 14.9 56.7 0.16 12.6 4.0 6.4 6 0 0 6 6 5 0 Human growth factor-like EGF Big_9 PF17963.1 CDW55955.1 - 0.17 12.6 46.3 6.7 7.5 0.1 14.2 16 0 0 16 16 14 0 Bacterial Ig domain Cadherin_4 PF17803.1 CDW55955.1 - 0.18 12.5 45.3 1.8 9.2 0.0 13.2 14 0 0 14 14 14 0 Bacterial cadherin-like domain EGF_2 PF07974.13 CDW55955.1 - 0.88 10.0 70.2 0.0063 16.9 6.5 6.1 5 1 0 5 5 5 0 EGF-like domain Invasin_D3 PF09134.10 CDW55955.1 - 3.2 8.1 7.1 43 4.5 0.2 5.3 5 1 0 5 5 5 0 Invasin, domain 3 TAF6_C PF07571.13 CDW55957.1 - 7.6e-18 64.6 0.1 1.7e-17 63.5 0.1 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 CDW55957.1 - 0.016 15.4 0.1 0.036 14.2 0.1 1.6 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) Peptidase_M76 PF09768.9 CDW55957.1 - 0.086 12.6 0.1 0.31 10.8 0.2 1.8 2 0 0 2 2 2 0 Peptidase M76 family Nodulin_late PF07127.11 CDW55958.1 - 0.065 13.6 0.8 0.065 13.6 0.8 2.3 2 1 0 2 2 2 0 Late nodulin protein Dickkopf_N PF04706.12 CDW55958.1 - 0.089 13.3 11.7 0.57 10.7 11.9 2.0 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Neuroparsin PF07327.11 CDW55958.1 - 0.13 12.7 4.5 0.18 12.3 4.5 1.2 1 0 0 1 1 1 0 Neuroparsin EB PF01683.18 CDW55958.1 - 0.68 10.3 8.9 13 6.2 8.9 2.1 1 1 0 1 1 1 0 EB module Rcd1 PF04078.13 CDW55959.1 - 7.4e-22 77.9 2.4 9.3e-22 77.6 2.4 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like dsrm PF00035.26 CDW55960.1 - 7.4e-08 33.0 0.2 0.00013 22.6 0.4 2.4 2 0 0 2 2 2 2 Double-stranded RNA binding motif UMPH-1 PF05822.12 CDW55961.1 - 9e-68 228.4 0.0 1.1e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 CDW55961.1 - 6.3e-08 33.2 0.0 9.9e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Rcd1 PF04078.13 CDW55962.1 - 2.5e-118 394.1 2.0 2.8e-118 393.9 2.0 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Macro PF01661.21 CDW55962.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Macro domain DUF4148 PF13663.6 CDW55962.1 - 0.97 9.7 6.9 1.8 8.8 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) AA_permease PF00324.21 CDW55963.1 - 5.1e-60 203.4 25.7 1.7e-42 145.6 4.0 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 CDW55963.1 - 2.9e-49 168.3 10.0 2.5e-17 63.1 0.7 3.5 2 2 2 4 4 4 3 Solute carrier family 12 PHO4 PF01384.20 CDW55964.1 - 1.8e-108 362.6 18.4 6.1e-91 305.0 12.3 2.1 2 0 0 2 2 2 2 Phosphate transporter family DUF4516 PF14990.6 CDW55964.1 - 0.11 12.2 3.2 7.1 6.5 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4516) Motile_Sperm PF00635.26 CDW55965.1 - 3e-13 49.6 0.0 6.8e-13 48.4 0.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Pribosyltran PF00156.27 CDW55966.1 - 2.5e-07 30.4 0.0 4.7e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyltran_N PF13793.6 CDW55966.1 - 0.00013 21.9 0.0 0.0018 18.2 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Innexin PF00876.18 CDW55967.1 - 4.2e-114 381.5 14.8 4.9e-114 381.3 14.8 1.0 1 0 0 1 1 1 1 Innexin Pkinase PF00069.25 CDW55968.1 - 2.1e-14 53.5 0.0 2.7e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW55968.1 - 0.00035 19.9 0.0 0.00041 19.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Voltage_CLC PF00654.20 CDW55969.1 - 3.1e-68 230.6 22.1 3.1e-68 230.6 22.1 2.9 1 1 1 2 2 2 1 Voltage gated chloride channel Voltage_CLC PF00654.20 CDW55970.1 - 9e-69 232.4 24.7 9e-69 232.4 24.7 1.7 1 1 1 2 2 2 2 Voltage gated chloride channel Histone PF00125.24 CDW55971.1 - 5.8e-16 59.0 0.4 7.1e-16 58.8 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 CDW55971.1 - 0.016 15.2 0.1 0.024 14.7 0.1 1.2 1 1 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 CDW55971.1 - 0.026 14.6 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold ATG11 PF10377.9 CDW55972.1 - 9.1e-11 41.9 0.0 2.1e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein 11 TBK1_ULD PF18396.1 CDW55972.1 - 1.7e-05 24.7 0.0 9.1e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain TPR_MLP1_2 PF07926.12 CDW55972.1 - 0.016 15.3 1.0 0.12 12.4 0.3 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Snapin_Pallidin PF14712.6 CDW55972.1 - 0.026 14.9 2.5 9.3 6.7 0.1 4.2 3 0 0 3 3 3 0 Snapin/Pallidin ubiquitin PF00240.23 CDW55972.1 - 0.089 12.6 0.0 0.37 10.6 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin family Baculo_PEP_C PF04513.12 CDW55972.1 - 0.16 12.0 1.7 12 6.0 0.4 2.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-F_leu_zip PF10473.9 CDW55972.1 - 3.7 7.6 5.3 0.8 9.7 0.3 2.5 2 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KELK PF15796.5 CDW55972.1 - 5 7.7 6.5 1.1 9.8 0.2 3.1 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase APP_E2 PF12925.7 CDW55973.1 - 3.1e-56 190.1 19.9 8.9e-56 188.6 19.9 1.8 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.16 CDW55973.1 - 7.9e-38 128.9 0.6 2.5e-37 127.3 0.6 1.9 1 0 0 1 1 1 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.7 CDW55973.1 - 3.6e-21 75.7 3.7 3.6e-21 75.7 3.7 2.2 2 0 0 2 2 2 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.9 CDW55973.1 - 9.1e-13 48.5 0.1 8.1e-12 45.5 0.1 2.7 1 1 0 1 1 1 1 Beta-amyloid precursor protein C-terminus Microvir_H PF04687.12 CDW55973.1 - 1.4 8.2 8.5 1.5 8.2 0.5 2.2 1 1 1 2 2 2 0 Microvirus H protein (pilot protein) RRM_1 PF00076.22 CDW55974.1 - 9.7e-12 44.5 0.0 1.5e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.9 CDW55974.1 - 0.23 10.3 12.9 0.28 10.0 12.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDW55974.1 - 1.8 7.0 14.1 2 6.9 14.1 1.1 1 0 0 1 1 1 0 Macoilin family Lig_chan PF00060.26 CDW55975.1 - 7.2e-43 146.0 0.1 9.8e-43 145.5 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 CDW55975.1 - 1.2e-25 89.9 0.0 2.9e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 CDW55975.1 - 5.7e-16 58.6 0.0 7.6e-15 54.9 0.0 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.16 CDW55975.1 - 0.00026 20.9 0.3 0.00026 20.9 0.3 2.4 2 0 0 2 2 2 1 Ion channel MRF_C2 PF13888.6 CDW55976.1 - 2.5e-24 85.8 0.0 6.9e-24 84.3 0.0 1.8 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 NDT80_PhoG PF05224.12 CDW55976.1 - 3.4e-23 82.8 2.0 1e-21 78.0 2.7 2.5 2 1 0 2 2 2 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.6 CDW55976.1 - 1.4e-19 69.0 0.1 2.5e-19 68.1 0.1 1.5 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.6 CDW55976.1 - 1.6e-10 41.1 0.3 3.8e-10 39.9 0.0 1.8 2 0 0 2 2 2 1 Chaperone of endosialidase hDGE_amylase PF14701.6 CDW55977.1 - 4e-115 385.4 2.9 5.6e-115 384.9 2.9 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 CDW55977.1 - 2.3e-88 296.7 2.4 7e-76 255.6 1.2 3.1 3 0 0 3 3 3 2 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 CDW55977.1 - 5.1e-24 85.3 1.8 1.1e-13 51.5 0.1 2.4 2 0 0 2 2 2 2 Central domain of human glycogen debranching enzyme Gcd10p PF04189.13 CDW55978.1 - 1.6e-50 171.9 0.0 2.4e-50 171.4 0.0 1.3 1 0 0 1 1 1 1 Gcd10p family TP6A_N PF04406.14 CDW55979.1 - 4.6e-05 23.3 0.1 7.8e-05 22.6 0.1 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Cullin PF00888.22 CDW55980.1 - 2.4e-72 244.5 0.1 3e-72 244.1 0.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CDW55980.1 - 8.9e-22 76.9 1.2 2.1e-21 75.7 1.2 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain Rad60-SLD PF11976.8 CDW55981.1 - 1.4e-16 60.1 0.0 1.4e-10 40.8 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDW55981.1 - 9.2e-08 31.7 0.0 0.0023 17.6 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin family SNRNP27 PF08648.12 CDW55982.1 - 6.2e-19 67.8 0.7 6.7e-19 67.7 0.7 1.0 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins TGF_beta PF00019.20 CDW55983.1 - 2e-36 125.1 0.7 4.9e-36 123.9 0.7 1.7 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 CDW55983.1 - 0.0018 18.1 0.1 0.011 15.5 0.1 2.1 1 1 0 1 1 1 1 TGF-beta propeptide TMEM131_like PF12371.8 CDW55984.1 - 2.5e-11 43.7 0.0 9.9e-10 38.6 0.0 2.6 2 0 0 2 2 2 1 Transmembrane protein 131-like ASH PF15780.5 CDW55984.1 - 2.4e-05 24.4 0.1 0.039 14.2 0.0 3.2 3 0 0 3 3 3 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin p53-inducible11 PF14936.6 CDW55985.1 - 5.6e-13 49.4 0.0 1e-12 48.5 0.0 1.3 1 1 0 1 1 1 1 Tumour protein p53-inducible protein 11 Cadherin_C_2 PF16492.5 CDW55985.1 - 7.6 7.4 10.0 0.99 10.2 0.5 2.9 2 1 1 3 3 3 0 Cadherin cytoplasmic C-terminal ThiF PF00899.21 CDW55986.1 - 5.4e-22 78.3 0.0 5.4e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.6 CDW55986.1 - 0.0066 16.9 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding 7tm_1 PF00001.21 CDW55987.1 - 1.7e-29 103.0 13.4 1.1e-28 100.3 13.4 1.9 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TMEM154 PF15102.6 CDW55987.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family FAA_hydrolase PF01557.18 CDW55988.1 - 4.6e-60 203.0 0.0 5.2e-60 202.8 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Proteasome PF00227.26 CDW55989.1 - 4.7e-24 84.9 0.2 2.9e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit DNase_II PF03265.15 CDW55990.1 - 1.2e-22 80.6 5.5 1.6e-22 80.3 1.7 2.0 1 1 1 2 2 2 2 Deoxyribonuclease II Collagen_bind_2 PF12904.7 CDW55990.1 - 0.00014 21.8 0.1 0.0079 16.2 0.1 2.4 2 0 0 2 2 2 1 Putative collagen-binding domain of a collagenase DUF3511 PF12023.8 CDW55990.1 - 0.02 14.7 0.0 0.057 13.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3511) APAF1_C PF17908.1 CDW55991.1 - 3.4e-17 62.7 0.2 7.4e-17 61.6 0.2 1.6 1 0 0 1 1 1 1 APAF-1 helical domain WD40 PF00400.32 CDW55991.1 - 5.8e-17 61.8 22.7 0.0039 18.0 1.1 9.2 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW55991.1 - 3e-15 56.3 0.1 0.00051 20.3 0.0 6.3 6 2 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain G-patch_2 PF12656.7 CDW55992.1 - 9.6e-21 73.6 0.1 2.6e-20 72.3 0.1 1.7 1 0 0 1 1 1 1 G-patch domain KN17_SH3 PF18131.1 CDW55992.1 - 4.2e-06 26.8 0.1 4.2e-06 26.8 0.1 2.8 4 0 0 4 4 4 1 KN17 SH3-like C-terminal domain G-patch PF01585.23 CDW55992.1 - 0.012 15.5 0.5 0.023 14.6 0.5 1.5 1 0 0 1 1 1 0 G-patch domain Tudor_2 PF18104.1 CDW55992.1 - 0.078 12.7 0.7 0.21 11.3 0.7 1.8 1 1 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain HMG_CoA_synt_N PF01154.17 CDW55993.1 - 1.1e-75 253.3 0.1 1.7e-75 252.7 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal tRNA-synt_1d PF00750.19 CDW55993.1 - 5.8e-64 216.2 0.0 8.3e-64 215.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) HMG_CoA_synt_C PF08540.10 CDW55993.1 - 1.9e-55 188.5 0.0 2.8e-54 184.6 0.0 2.2 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal DALR_1 PF05746.15 CDW55993.1 - 5.9e-09 36.1 0.3 1.4e-08 34.9 0.3 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain ACP_syn_III PF08545.10 CDW55993.1 - 0.007 16.2 0.3 0.028 14.3 0.1 2.1 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Pkip-1 PF06878.11 CDW55993.1 - 0.031 14.4 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Pkip-1 protein GATase_5 PF13507.6 CDW55995.1 - 2.2e-75 253.1 0.1 8.4e-38 130.0 0.3 3.7 2 1 1 3 3 3 2 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 CDW55995.1 - 1.1e-29 103.6 0.1 1.6e-18 67.3 0.1 2.4 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 CDW55995.1 - 6.6e-16 58.3 0.0 1.6e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 CDW55995.1 - 8.8e-12 45.4 0.1 2.3e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain Tegument_dsDNA PF12818.7 CDW55995.1 - 0.13 11.3 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 dsDNA viral tegument protein Tim44 PF04280.15 CDW55996.1 - 7.2e-26 91.0 0.3 9.7e-26 90.6 0.3 1.2 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 CDW55996.1 - 0.00021 20.4 0.0 0.00038 19.6 0.0 1.3 1 0 0 1 1 1 1 MBA1-like protein SAP PF02037.27 CDW55996.1 - 0.071 12.9 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 SAP domain DSS1_SEM1 PF05160.13 CDW55997.1 - 1.6e-14 53.7 15.5 2.5e-14 53.1 15.5 1.3 1 0 0 1 1 1 1 DSS1/SEM1 family Amidohydro_1 PF01979.20 CDW55998.1 - 9.2e-16 58.1 0.1 2e-15 57.0 0.1 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDW55998.1 - 4.2e-06 26.5 0.0 9.7e-05 22.0 0.0 2.3 3 0 0 3 3 3 1 Amidohydrolase family CD36 PF01130.21 CDW55999.1 - 1.9e-116 389.4 0.1 5.2e-114 381.3 0.1 2.2 1 1 0 1 1 1 1 CD36 family DSS1_SEM1 PF05160.13 CDW55999.1 - 3e-10 40.0 8.2 3e-10 40.0 8.2 1.8 2 0 0 2 2 2 1 DSS1/SEM1 family Ribosomal_L14 PF00238.19 CDW56000.1 - 9.3e-16 58.0 0.0 1.6e-15 57.3 0.0 1.4 1 1 0 1 1 1 1 Ribosomal protein L14p/L23e SRP54 PF00448.22 CDW56001.1 - 5.5e-51 173.0 0.6 2.3e-50 171.0 0.2 2.1 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 CDW56001.1 - 1.9e-28 100.2 0.9 2.7e-28 99.8 0.9 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 CDW56001.1 - 2.3e-08 34.2 0.0 1.2e-07 31.9 0.0 2.2 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 CDW56001.1 - 3.7e-06 26.1 0.0 6.5e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 CDW56001.1 - 0.00067 19.9 0.0 0.0027 18.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CDW56001.1 - 0.0014 18.4 0.0 0.003 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CDW56001.1 - 0.0024 17.8 0.1 0.054 13.4 0.1 2.6 1 1 0 1 1 1 1 NTPase AAA_16 PF13191.6 CDW56001.1 - 0.003 18.0 0.3 0.15 12.5 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Fer4_NifH PF00142.18 CDW56001.1 - 0.0045 16.5 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SCAB-PH PF17684.1 CDW56001.1 - 0.016 15.5 0.1 0.054 13.7 0.1 1.9 2 0 0 2 2 2 0 PH domain of plant-specific actin-binding protein CbiA PF01656.23 CDW56001.1 - 0.019 15.0 0.0 0.12 12.4 0.0 2.2 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 CDW56001.1 - 0.036 14.2 0.0 0.15 12.1 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_31 PF13614.6 CDW56001.1 - 0.046 13.6 0.0 0.88 9.5 0.0 2.3 1 1 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 CDW56001.1 - 0.051 12.8 0.0 0.52 9.4 0.0 2.3 2 0 0 2 2 2 0 Anion-transporting ATPase AAA_33 PF13671.6 CDW56001.1 - 0.06 13.5 0.4 0.49 10.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 CDW56001.1 - 0.066 13.6 0.0 0.73 10.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDW56001.1 - 0.08 13.2 0.3 26 5.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 CDW56001.1 - 0.099 12.3 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain MIF PF01187.18 CDW56002.1 - 1.8e-44 150.7 0.0 1.6e-34 118.6 0.0 2.0 2 0 0 2 2 2 2 Macrophage migration inhibitory factor (MIF) OKR_DC_1_N PF03709.15 CDW56002.1 - 0.07 13.4 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain NifU_N PF01592.16 CDW56003.1 - 1.6e-57 193.2 0.2 1.9e-57 193.0 0.2 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain DUF3659 PF12396.8 CDW56003.1 - 0.1 12.5 0.3 0.17 11.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3659) BCDHK_Adom3 PF10436.9 CDW56004.1 - 1.1e-39 135.9 0.8 1.8e-39 135.2 0.8 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CDW56004.1 - 6e-11 42.8 0.0 1.3e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CDW56004.1 - 0.00092 19.1 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDW56004.1 - 0.098 12.6 0.0 0.33 10.9 0.0 1.9 2 0 0 2 2 2 0 GHKL domain ANAPC4_WD40 PF12894.7 CDW56005.1 - 6e-05 23.3 0.1 0.0051 17.1 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain NHL PF01436.21 CDW56005.1 - 0.039 14.0 0.5 24 5.2 0.0 4.0 4 0 0 4 4 4 0 NHL repeat Kinetochor_Ybp2 PF08568.10 CDW56008.1 - 0.021 13.3 0.5 0.041 12.4 0.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin EGF PF00008.27 CDW56009.1 - 4.3e-06 26.9 30.6 0.0016 18.7 10.1 3.7 3 0 0 3 3 3 3 EGF-like domain EGF_CA PF07645.15 CDW56009.1 - 0.0005 20.2 40.3 0.00076 19.6 8.8 4.1 4 1 0 4 4 4 2 Calcium-binding EGF domain EGF_2 PF07974.13 CDW56009.1 - 0.068 13.6 35.2 0.18 12.2 10.7 4.2 3 1 0 3 3 3 0 EGF-like domain CRAM_rpt PF07016.11 CDW56009.1 - 0.095 12.5 0.4 0.095 12.5 0.4 2.5 2 0 0 2 2 2 0 Cysteine-rich acidic integral membrane protein precursor hEGF PF12661.7 CDW56009.1 - 2.5 8.9 22.3 0.21 12.3 6.2 3.8 3 1 0 3 3 3 0 Human growth factor-like EGF Pkinase PF00069.25 CDW56010.1 - 5.7e-48 163.6 0.0 7.2e-34 117.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56010.1 - 4e-28 98.4 0.0 9e-21 74.3 0.1 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CDW56010.1 - 0.0016 17.8 0.0 0.0032 16.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like DUF2140 PF09911.9 CDW56010.1 - 0.0046 16.5 0.3 0.02 14.4 0.2 2.0 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2140) Kdo PF06293.14 CDW56010.1 - 0.052 12.9 0.2 0.14 11.5 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ras PF00071.22 CDW56011.1 - 8.1e-53 178.3 0.0 9.4e-53 178.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW56011.1 - 8e-31 106.8 0.0 1.1e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW56011.1 - 9e-13 48.0 0.0 1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW56011.1 - 0.00019 21.5 0.0 0.00023 21.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW56011.1 - 0.00027 20.4 0.0 0.00031 20.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDW56011.1 - 0.0075 15.7 0.0 0.0084 15.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDW56011.1 - 0.012 15.2 0.0 0.032 13.8 0.0 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CDW56011.1 - 0.029 14.1 0.0 0.53 10.0 0.0 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DHHC PF01529.20 CDW56012.1 - 6.8e-36 123.3 15.1 6.8e-36 123.3 15.1 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase DnaT PF17948.1 CDW56012.1 - 0.0078 15.9 0.2 0.017 14.8 0.2 1.5 1 0 0 1 1 1 1 DnaT DNA-binding domain Spt4 PF06093.13 CDW56012.1 - 0.89 9.7 4.2 1.7 8.8 4.2 1.4 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger FBPase PF00316.20 CDW56013.1 - 5.9e-73 244.4 0.3 7.8e-73 244.0 0.3 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CDW56013.1 - 0.00014 21.5 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family PP2C PF00481.21 CDW56014.1 - 3.3e-67 226.8 0.0 6.4e-67 225.9 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C zf-RING_2 PF13639.6 CDW56015.1 - 2e-12 47.2 7.2 4.7e-12 46.1 7.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW56015.1 - 1.9e-08 34.0 8.4 3.9e-08 33.0 8.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDW56015.1 - 4.4e-08 33.3 5.6 9.1e-08 32.3 5.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CDW56015.1 - 1.1e-07 31.5 3.6 1.1e-07 31.5 3.6 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDW56015.1 - 1e-06 28.5 6.5 2e-06 27.6 6.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW56015.1 - 9.9e-06 25.4 4.8 1.9e-05 24.5 4.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CDW56015.1 - 0.00012 22.1 3.8 0.00023 21.1 3.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CDW56015.1 - 0.00019 21.4 6.6 0.00038 20.4 6.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW56015.1 - 0.0052 16.6 3.5 0.011 15.5 3.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CrgA PF06781.12 CDW56015.1 - 0.014 15.5 0.2 0.028 14.5 0.2 1.4 1 0 0 1 1 1 0 Cell division protein CrgA PspB PF06667.12 CDW56015.1 - 0.036 14.1 0.3 0.073 13.1 0.3 1.5 1 0 0 1 1 1 0 Phage shock protein B Prok-RING_4 PF14447.6 CDW56015.1 - 0.049 13.5 7.7 0.31 10.9 8.1 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Prok-RING_1 PF14446.6 CDW56015.1 - 0.081 12.9 5.9 0.043 13.8 2.4 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 CDW56015.1 - 0.19 11.4 5.4 0.87 9.3 5.7 1.9 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 CDW56015.1 - 0.43 10.5 5.0 0.89 9.5 5.0 1.6 1 0 0 1 1 1 0 PHD-finger zf-C3H2C3 PF17122.5 CDW56015.1 - 1.8 8.6 8.8 0.17 11.9 3.5 2.1 2 0 0 2 2 2 0 Zinc-finger RNA_pol_Rpb1_5 PF04998.17 CDW56016.1 - 3.1e-102 341.6 0.1 5e-102 340.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 CDW56016.1 - 6e-98 328.0 0.1 1e-97 327.3 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 CDW56016.1 - 2.8e-74 248.9 0.0 6.7e-74 247.6 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 CDW56016.1 - 7.4e-65 218.4 0.6 1.7e-64 217.2 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 CDW56016.1 - 2.8e-49 166.6 3.5 6.3e-49 165.4 3.5 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 CDW56016.1 - 3.7e-44 150.4 0.1 1.6e-43 148.3 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CDW56016.1 - 6.5e-39 132.2 0.3 2.5e-38 130.3 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 CDW56016.1 - 0.0016 18.7 363.0 0.027 14.8 12.0 24.7 14 5 8 26 26 26 18 RNA polymerase Rpb1 C-terminal repeat DUF5487 PF17589.2 CDW56017.1 - 0.017 15.4 0.1 0.035 14.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5487) Trehalase PF01204.18 CDW56018.1 - 3e-284 943.6 1.8 3.2e-144 481.6 0.0 3.0 2 1 1 3 3 3 3 Trehalase GDE_C PF06202.14 CDW56018.1 - 5.6e-11 42.0 0.7 0.00012 21.2 0.1 2.4 2 0 0 2 2 2 2 Amylo-alpha-1,6-glucosidase Glyco_hydro_63 PF03200.16 CDW56018.1 - 0.0098 14.7 4.0 0.5 9.0 0.3 3.2 2 2 1 3 3 3 3 Glycosyl hydrolase family 63 C-terminal domain YmgB PF10798.8 CDW56018.1 - 0.03 14.2 0.0 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Biofilm development protein YmgB/AriR Mo25 PF08569.11 CDW56019.1 - 3.2e-113 378.4 9.5 2.1e-112 375.8 9.5 1.8 1 1 0 1 1 1 1 Mo25-like HLH PF00010.26 CDW56020.1 - 1.2e-16 60.4 1.6 2.3e-16 59.5 1.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 CDW56020.1 - 3.9e-11 43.0 0.0 1.1e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 Hairy Orange LIM PF00412.22 CDW56021.1 - 4.4e-47 158.1 51.7 1.5e-14 53.9 3.0 5.1 5 0 0 5 5 5 4 LIM domain Ribosomal_L35Ae PF01247.18 CDW56021.1 - 3.9e-43 145.5 1.7 6.7e-43 144.8 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L35Ae DUF4503 PF14951.6 CDW56021.1 - 0.022 13.3 4.7 1.2 7.5 1.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4503) DUF3836 PF12930.7 CDW56021.1 - 0.06 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF3836) RimM PF01782.18 CDW56021.1 - 0.14 12.3 0.3 23 5.3 0.0 2.5 3 0 0 3 3 3 0 RimM N-terminal domain zinc-ribbons_6 PF07191.12 CDW56021.1 - 3 7.9 40.5 0.68 10.0 8.3 5.6 2 2 2 4 4 4 0 zinc-ribbons PKI PF02827.16 CDW56022.1 - 0.0013 18.9 0.0 0.0015 18.7 0.0 1.2 1 0 0 1 1 1 1 cAMP-dependent protein kinase inhibitor Motile_Sperm PF00635.26 CDW56023.1 - 6.1e-18 64.7 0.1 7.5e-18 64.4 0.1 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain PapD_N PF00345.20 CDW56023.1 - 0.0078 16.1 0.2 0.0095 15.8 0.2 1.2 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain ASH PF15780.5 CDW56023.1 - 0.041 14.1 0.4 0.11 12.7 0.5 1.6 1 1 1 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin AAA PF00004.29 CDW56024.1 - 2.5e-45 154.1 0.0 6.1e-45 152.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW56024.1 - 1.1e-12 47.6 0.1 2.4e-12 46.4 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDW56024.1 - 2.4e-11 43.4 0.1 1.4e-10 40.9 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CDW56024.1 - 4.5e-09 36.4 0.1 2e-08 34.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDW56024.1 - 1.8e-08 34.7 0.0 7.4e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDW56024.1 - 2.4e-07 31.3 0.5 0.00015 22.2 0.0 3.2 3 1 1 4 4 3 1 AAA ATPase domain RuvB_N PF05496.12 CDW56024.1 - 5.4e-05 23.0 0.0 0.00016 21.5 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 CDW56024.1 - 5.7e-05 22.4 0.0 0.00013 21.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 CDW56024.1 - 0.00012 22.4 1.2 0.012 15.9 0.0 2.8 2 1 1 3 3 3 1 AAA domain IstB_IS21 PF01695.17 CDW56024.1 - 0.0002 21.2 0.0 0.0014 18.4 0.0 2.2 1 1 1 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 CDW56024.1 - 0.00026 21.5 0.0 0.00095 19.7 0.0 2.0 3 0 0 3 3 1 1 AAA domain RNA_helicase PF00910.22 CDW56024.1 - 0.0004 20.7 0.0 0.00088 19.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 CDW56024.1 - 0.00046 20.5 0.0 0.0012 19.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CDW56024.1 - 0.00053 20.0 0.0 0.0026 17.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 CDW56024.1 - 0.00086 19.3 0.0 0.079 12.9 0.0 3.0 3 0 0 3 3 3 1 NTPase Mg_chelatase PF01078.21 CDW56024.1 - 0.00099 18.5 0.2 0.0026 17.2 0.1 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDW56024.1 - 0.0017 18.0 0.1 0.41 10.3 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain NACHT PF05729.12 CDW56024.1 - 0.0032 17.4 0.1 0.03 14.2 0.1 2.3 2 0 0 2 2 2 1 NACHT domain Prot_ATP_OB_N PF17758.1 CDW56024.1 - 0.0051 16.4 0.1 0.042 13.5 0.0 2.4 3 0 0 3 3 2 1 Proteasomal ATPase OB N-terminal domain AAA_33 PF13671.6 CDW56024.1 - 0.0053 16.9 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 CDW56024.1 - 0.007 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CDW56024.1 - 0.0088 16.0 0.4 0.089 12.7 0.0 2.4 2 1 0 3 3 2 1 ATPase domain predominantly from Archaea TniB PF05621.11 CDW56024.1 - 0.012 15.1 0.0 0.89 8.9 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 CDW56024.1 - 0.013 15.0 2.5 0.022 14.3 0.1 2.3 2 1 1 3 3 2 0 AAA domain NB-ARC PF00931.22 CDW56024.1 - 0.017 14.3 0.3 0.093 11.9 0.0 2.2 3 0 0 3 3 3 0 NB-ARC domain CENP-F_leu_zip PF10473.9 CDW56024.1 - 0.018 15.1 0.2 0.031 14.3 0.2 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_7 PF12775.7 CDW56024.1 - 0.021 14.3 0.0 0.16 11.5 0.0 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 CDW56024.1 - 0.022 14.0 0.0 0.043 13.0 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_24 PF13479.6 CDW56024.1 - 0.024 14.3 0.1 0.051 13.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDW56024.1 - 0.026 15.0 0.1 0.16 12.5 0.0 2.2 2 1 0 2 2 2 0 ABC transporter AAA_3 PF07726.11 CDW56024.1 - 0.037 13.9 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 CDW56024.1 - 0.06 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 CDW56024.1 - 0.073 12.8 0.1 0.21 11.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDW56024.1 - 0.086 12.1 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin FTR1 PF03239.14 CDW56026.1 - 0.058 12.6 0.0 0.068 12.3 0.0 1.1 1 0 0 1 1 1 0 Iron permease FTR1 family Peptidase_M76 PF09768.9 CDW56028.1 - 1.2e-32 113.0 5.3 1.5e-32 112.7 5.3 1.1 1 0 0 1 1 1 1 Peptidase M76 family DUF3920 PF13058.6 CDW56028.1 - 0.042 14.0 0.0 0.088 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3920) FWWh PF14922.6 CDW56028.1 - 0.07 13.1 0.0 4.3 7.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function Peptidase_M78 PF06114.13 CDW56028.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 IrrE N-terminal-like domain Globin PF00042.22 CDW56029.1 - 4.7e-10 40.0 0.0 6.7e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Globin WD40 PF00400.32 CDW56030.1 - 1.1e-06 29.2 6.8 0.0044 17.8 0.1 4.8 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56030.1 - 0.049 13.9 0.0 0.9 9.9 0.0 2.8 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CDW56030.1 - 0.079 13.5 0.0 23 5.6 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain Porin_3 PF01459.22 CDW56031.1 - 4.4e-29 101.8 0.1 5.3e-29 101.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin Vg_Tdu PF07545.14 CDW56032.1 - 3.2e-06 26.8 1.0 0.077 12.8 0.1 2.6 2 0 0 2 2 2 2 Vestigial/Tondu family HSP70 PF00012.20 CDW56034.1 - 5.4e-264 876.9 7.0 6.6e-264 876.7 7.0 1.1 1 0 0 1 1 1 1 Hsp70 protein Ldh_1_N PF00056.23 CDW56034.1 - 6.2e-44 149.5 0.1 1.6e-43 148.2 0.1 1.8 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDW56034.1 - 1.1e-43 149.0 0.0 3.3e-43 147.5 0.0 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ribosomal_L13 PF00572.18 CDW56034.1 - 6.7e-30 103.9 0.0 1.4e-29 102.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L13 MreB_Mbl PF06723.13 CDW56034.1 - 3.4e-15 55.7 0.1 1e-13 50.9 0.0 2.3 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 CDW56034.1 - 0.04 14.3 0.0 12 6.4 0.0 2.9 2 0 0 2 2 2 0 Cell division protein FtsA FGGY_C PF02782.16 CDW56034.1 - 0.043 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain DUF1464 PF07318.12 CDW56034.1 - 0.059 12.5 0.0 0.78 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1464) THF_DHG_CYH_C PF02882.19 CDW56034.1 - 0.065 12.6 0.0 0.35 10.2 0.0 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Hydantoinase_A PF01968.18 CDW56034.1 - 0.1 11.8 2.0 0.11 11.7 0.3 1.9 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Ribosomal_L21p PF00829.21 CDW56035.1 - 4.4e-18 65.4 0.0 5.8e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Collagen PF01391.18 CDW56036.1 - 8.5e-24 83.1 95.8 1.1e-10 41.1 24.1 4.3 3 1 1 4 4 4 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW56036.1 - 1.1e-15 57.4 0.0 1.4e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain SH3_9 PF14604.6 CDW56037.1 - 5.4e-22 77.4 0.1 2.4e-11 43.3 0.1 2.8 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 CDW56037.1 - 3.8e-21 74.5 0.0 2.7e-10 39.7 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CDW56037.1 - 5.3e-11 41.9 0.0 1.5e-05 24.5 0.0 2.7 2 0 0 2 2 2 2 SH3 domain fn3 PF00041.21 CDW56037.1 - 0.00034 20.9 4.5 0.23 11.8 0.1 4.7 4 2 0 4 4 4 2 Fibronectin type III domain hSH3 PF14603.6 CDW56037.1 - 0.2 12.1 0.0 11 6.5 0.0 2.4 2 0 0 2 2 2 0 Helically-extended SH3 domain Peptidase_M10 PF00413.24 CDW56038.1 - 1.9e-43 148.0 0.2 2.3e-43 147.8 0.2 1.0 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 CDW56038.1 - 0.00015 22.3 0.4 0.0002 21.9 0.4 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 CDW56038.1 - 0.00086 19.3 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M54 DUF4953 PF16313.5 CDW56038.1 - 0.0085 15.3 0.5 0.02 14.1 0.1 1.8 2 0 0 2 2 2 1 Met-zincin Metallopep PF12044.8 CDW56038.1 - 0.0088 14.7 0.0 0.014 14.1 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_4 PF13583.6 CDW56038.1 - 0.0091 15.7 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CDW56038.1 - 0.016 15.4 0.7 0.024 14.8 0.7 1.4 1 1 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M57 PF12388.8 CDW56038.1 - 0.033 13.8 0.2 0.046 13.3 0.2 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Astacin PF01400.24 CDW56038.1 - 0.055 13.1 0.1 0.19 11.3 0.1 1.8 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Peptidase_M11 PF05548.11 CDW56038.1 - 0.15 11.2 0.2 0.23 10.6 0.2 1.2 1 0 0 1 1 1 0 Gametolysin peptidase M11 PID PF00640.23 CDW56039.1 - 4.5e-27 94.8 0.0 8.5e-27 93.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 CDW56039.1 - 1.9e-10 41.0 0.0 3.2e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 CDW56039.1 - 4e-07 30.1 0.0 5.7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) GIT_CC PF16559.5 CDW56039.1 - 0.031 14.2 0.8 0.082 12.8 0.8 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Hydrolase PF00702.26 CDW56040.1 - 1.1e-12 48.7 0.0 2.7e-12 47.4 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW56040.1 - 9.6e-07 29.4 0.0 1.8e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CDW56040.1 - 3.6e-06 26.6 0.4 5.8e-05 22.6 0.4 2.0 1 1 0 1 1 1 1 Putative Phosphatase UMPH-1 PF05822.12 CDW56040.1 - 1.3e-05 24.8 0.0 2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) RRM_7 PF16367.5 CDW56041.1 - 4e-19 68.5 0.0 3.2e-18 65.6 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 CDW56041.1 - 6e-13 48.8 4.7 1.2e-12 47.9 4.7 1.5 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 CDW56041.1 - 2.6e-09 36.8 0.0 1.1e-05 25.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.6 CDW56041.1 - 0.0061 16.2 0.0 0.079 12.6 0.0 2.4 2 0 0 2 2 2 1 Sporulation protein family 7 RNA_bind PF08675.11 CDW56041.1 - 0.0085 16.1 0.0 0.17 11.9 0.0 2.6 2 1 0 3 3 3 1 RNA binding domain Sugar_tr PF00083.24 CDW56042.1 - 7.8e-39 133.8 16.1 1.1e-38 133.3 16.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW56042.1 - 2.3e-30 105.8 31.4 1.6e-19 70.0 14.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Neur_chan_LBD PF02931.23 CDW56043.1 - 2.7e-27 95.6 0.1 7.3e-26 91.0 0.1 2.1 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW56043.1 - 7.1e-07 29.5 0.1 9.9e-07 29.1 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Astacin PF01400.24 CDW56044.1 - 4.7e-60 202.5 2.1 8.5e-60 201.7 2.1 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) FtsH_ext PF06480.15 CDW56044.1 - 0.26 11.7 1.9 0.5 10.7 0.6 2.1 2 0 0 2 2 2 0 FtsH Extracellular EGF_2 PF07974.13 CDW56044.1 - 3.7 8.0 12.4 2.5 8.5 9.5 2.3 2 0 0 2 2 2 0 EGF-like domain zf-H2C2_2 PF13465.6 CDW56046.1 - 3.5e-105 340.2 151.1 1.3e-09 38.0 0.4 20.3 20 1 1 21 21 21 18 Zinc-finger double domain zf-C2H2 PF00096.26 CDW56046.1 - 1.7e-71 232.9 166.4 2.6e-05 24.4 2.1 20.4 20 0 0 20 20 20 19 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW56046.1 - 2.6e-51 167.8 165.4 0.0009 19.9 0.5 20.6 19 2 1 20 20 20 20 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW56046.1 - 1e-19 70.0 153.8 4.8e-05 23.2 1.2 18.8 20 1 0 20 20 20 13 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW56046.1 - 2.3e-16 59.6 103.6 0.014 15.7 0.1 18.7 19 0 0 19 19 19 9 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW56046.1 - 6e-10 39.2 120.9 0.04 14.3 0.3 18.6 19 0 0 19 19 19 9 Zinc-finger of C2H2 type zf-Di19 PF05605.12 CDW56046.1 - 4e-05 23.8 4.4 4e-05 23.8 4.4 13.1 6 4 7 13 13 13 4 Drought induced 19 protein (Di19), zinc-binding C1_4 PF07975.12 CDW56046.1 - 0.045 14.0 89.4 0.45 10.8 0.7 13.7 6 3 6 14 14 14 0 TFIIH C1-like domain zf-Sec23_Sec24 PF04810.15 CDW56046.1 - 0.18 11.9 0.1 0.18 11.9 0.1 11.7 13 2 2 15 15 15 0 Sec23/Sec24 zinc finger PyrI_C PF02748.15 CDW56046.1 - 0.21 11.5 0.1 0.21 11.5 0.1 16.3 16 3 3 19 19 19 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain 7tm_1 PF00001.21 CDW56047.1 - 9.1e-54 182.5 26.2 1.4e-53 181.9 26.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW56047.1 - 8.6e-12 45.0 21.9 1.1e-11 44.6 21.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Histone PF00125.24 CDW56048.1 - 3.8e-37 127.6 0.0 1.5e-17 64.2 0.0 2.1 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CDW56048.1 - 5.8e-14 51.5 1.6 2.2e-10 40.1 0.1 2.6 2 0 0 2 2 2 2 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CDW56048.1 - 2.4e-08 34.1 0.0 0.015 15.6 0.0 2.8 3 0 0 3 3 3 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone IMS_C PF11799.8 CDW56048.1 - 0.0011 19.6 0.1 2.2 9.0 0.0 2.3 2 0 0 2 2 2 2 impB/mucB/samB family C-terminal domain Vps54 PF07928.12 CDW56048.1 - 0.021 15.2 0.7 9.1 6.7 0.1 2.4 2 0 0 2 2 2 0 Vps54-like protein NCD1 PF04904.13 CDW56048.1 - 0.028 14.4 0.0 14 5.8 0.0 2.5 2 0 0 2 2 2 0 NAB conserved region 1 (NCD1) His_Phos_2 PF00328.22 CDW56048.1 - 0.033 13.5 0.0 7.2 5.8 0.0 2.1 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) TFIID_30kDa PF03540.13 CDW56048.1 - 0.089 12.8 0.0 24 5.0 0.0 2.6 2 0 0 2 2 2 0 Transcription initiation factor TFIID 23-30kDa subunit Guanylate_kin PF00625.21 CDW56048.1 - 0.092 12.4 0.0 16 5.1 0.0 2.2 2 0 0 2 2 2 0 Guanylate kinase Innexin PF00876.18 CDW56049.1 - 5e-120 401.0 11.9 5.9e-120 400.8 11.9 1.0 1 0 0 1 1 1 1 Innexin Enkurin PF13864.6 CDW56050.1 - 1.1e-11 45.0 0.8 3.8e-11 43.3 0.2 2.0 2 0 0 2 2 2 1 Calmodulin-binding Metallophos PF00149.28 CDW56051.1 - 3.8e-31 109.2 0.1 5.2e-31 108.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW56051.1 - 0.0034 17.8 0.0 0.0058 17.1 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Dus PF01207.17 CDW56052.1 - 8.8e-96 320.6 0.0 5.4e-52 176.8 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) RNase_T PF00929.24 CDW56052.1 - 2.9e-27 96.2 0.0 5.4e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 Exonuclease Peptidase_M1 PF01433.20 CDW56052.1 - 5.3e-06 26.2 0.0 1.9e-05 24.3 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M1 domain zf-CCCH PF00642.24 CDW56052.1 - 3.8e-05 23.5 11.1 0.018 15.0 0.3 3.0 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDW56052.1 - 9.4e-05 22.1 0.4 9.4e-05 22.1 0.4 2.8 2 0 0 2 2 2 1 CCCH-type zinc finger Peptidase_M1_N PF17900.1 CDW56052.1 - 0.0025 18.0 0.0 0.0047 17.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain zf_CCCH_4 PF18345.1 CDW56052.1 - 0.0086 16.1 0.5 0.0086 16.1 0.5 3.0 2 0 0 2 2 2 1 Zinc finger domain HEAT PF02985.22 CDW56052.1 - 0.15 12.4 0.7 12 6.5 0.2 3.6 2 0 0 2 2 2 0 HEAT repeat Torus PF16131.5 CDW56052.1 - 3.4 8.4 4.9 0.87 10.3 0.1 2.2 1 1 1 2 2 2 0 Torus domain Thiolase_N PF00108.23 CDW56053.1 - 3e-85 285.7 0.5 4.3e-85 285.2 0.5 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDW56053.1 - 1.5e-42 144.1 1.7 4.8e-42 142.5 0.3 2.4 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDW56053.1 - 1e-06 28.5 1.7 2.2e-06 27.4 1.7 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CDW56053.1 - 0.19 11.6 6.4 3.8 7.4 0.5 3.3 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III CUE PF02845.16 CDW56054.1 - 4.4e-12 45.5 0.1 9.1e-12 44.4 0.1 1.6 1 0 0 1 1 1 1 CUE domain C2 PF00168.30 CDW56054.1 - 4.6e-10 39.7 0.0 7.9e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 C2 domain Glycos_transf_2 PF00535.26 CDW56055.1 - 1.2e-36 126.1 0.0 1.7e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDW56055.1 - 4.2e-13 49.7 0.0 2e-12 47.5 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CDW56055.1 - 1e-05 25.2 0.0 1.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CDW56055.1 - 0.025 14.1 0.0 0.041 13.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 CDW56055.1 - 0.025 15.1 0.0 0.15 12.6 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 2 Reticulon PF02453.17 CDW56056.1 - 2.6e-09 37.2 2.9 4e-09 36.6 2.9 1.3 1 0 0 1 1 1 1 Reticulon TMEM237 PF15383.6 CDW56056.1 - 0.02 14.0 0.7 0.041 13.0 0.7 1.5 1 0 0 1 1 1 0 Transmembrane protein 237 TTD PF12148.8 CDW56056.1 - 0.038 13.8 0.3 0.074 12.9 0.1 1.6 1 1 1 2 2 2 0 Tandem tudor domain within UHRF1 DUF2207 PF09972.9 CDW56056.1 - 0.087 11.6 0.1 0.12 11.1 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4736 PF15883.5 CDW56056.1 - 0.22 11.2 1.7 0.75 9.5 1.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4736) zf-C2H2 PF00096.26 CDW56057.1 - 5.9e-06 26.4 10.2 0.00032 21.0 0.9 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW56057.1 - 0.00028 21.4 10.3 0.02 15.7 0.7 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW56057.1 - 0.0027 17.6 4.4 1.2 9.3 0.5 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 CDW56057.1 - 0.0041 17.5 4.8 0.78 10.2 0.4 3.3 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 CDW56057.1 - 0.01 16.2 7.3 0.099 13.1 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_8 PF15909.5 CDW56057.1 - 0.015 15.6 2.0 0.046 14.0 2.0 1.9 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 CDW56057.1 - 0.043 14.5 2.3 0.14 12.8 0.2 2.1 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats LIM PF00412.22 CDW56057.1 - 0.1 12.9 1.7 0.7 10.2 0.1 2.8 3 0 0 3 3 3 0 LIM domain DUF2256 PF10013.9 CDW56057.1 - 0.13 12.4 2.4 1.2 9.3 0.1 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2HC_2 PF13913.6 CDW56057.1 - 6.5 6.8 7.6 3.1 7.8 1.6 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Cnd3 PF12719.7 CDW56058.1 - 8.5e-40 136.8 0.6 8.5e-40 136.8 0.6 2.4 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 CDW56058.1 - 2.9e-09 37.2 0.3 5.7e-05 23.4 0.1 3.3 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 CDW56058.1 - 6.7e-05 22.8 1.3 3.7 8.1 0.1 4.9 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 CDW56058.1 - 0.00032 20.8 5.5 0.024 14.7 0.0 4.8 4 2 2 6 6 6 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CDW56058.1 - 0.025 15.1 5.8 0.92 10.1 0.0 4.6 6 0 0 6 6 6 0 HEAT-like repeat McrBC PF10117.9 CDW56058.1 - 0.073 12.2 0.1 0.16 11.1 0.1 1.5 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component Vac14_Fab1_bd PF12755.7 CDW56058.1 - 0.091 13.4 2.4 3.7 8.2 0.0 3.7 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region Collagen PF01391.18 CDW56059.1 - 6.4e-23 80.3 100.8 5.4e-08 32.5 41.4 4.1 2 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW56059.1 - 2.8e-15 56.1 1.0 3.6e-15 55.7 1.0 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain DUF1878 PF08963.10 CDW56060.1 - 0.049 14.1 0.7 3.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1878) IKKbetaNEMObind PF12179.8 CDW56060.1 - 0.18 11.9 2.2 4.1 7.5 0.0 2.4 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain N6-adenineMlase PF10237.9 CDW56061.1 - 9.3e-50 168.6 0.3 1.1e-49 168.3 0.3 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.15 CDW56061.1 - 0.073 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PHD PF00628.29 CDW56062.1 - 4.3e-06 26.5 10.3 6.6e-06 25.9 10.3 1.3 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 CDW56062.1 - 0.053 13.1 3.3 0.076 12.6 3.3 1.2 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain zf-C4H2 PF10146.9 CDW56062.1 - 2.3 8.5 4.9 2.8 8.2 4.9 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein DUF2046 PF09755.9 CDW56063.1 - 1.2e-136 454.8 53.6 1.5e-136 454.6 53.6 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) ATG16 PF08614.11 CDW56063.1 - 0.09 13.0 60.2 1.7 8.8 13.5 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF3828 PF12883.7 CDW56063.1 - 0.29 11.5 3.2 1.2 9.5 2.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3828) HOCHOB PF17943.1 CDW56063.1 - 1.2 9.8 4.9 0.24 12.1 0.5 2.1 2 1 0 2 2 2 0 Homeobox-cysteine loop-homeobox Trypsin_2 PF13365.6 CDW56064.1 - 1.3e-26 94.3 0.8 2e-26 93.7 0.8 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 CDW56064.1 - 4.9e-13 49.4 0.0 8.7e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 CDW56064.1 - 4e-10 39.4 0.1 9e-10 38.3 0.1 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW56064.1 - 2.6e-09 37.3 0.0 6.7e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW56064.1 - 1.5e-07 31.6 0.1 7e-07 29.5 0.0 2.0 2 0 0 2 2 2 1 PDZ domain LSM PF01423.22 CDW56064.1 - 0.006 16.2 0.0 0.019 14.7 0.0 1.9 1 0 0 1 1 1 1 LSM domain Peptidase_S46 PF10459.9 CDW56064.1 - 0.0075 15.0 2.8 0.026 13.2 0.4 2.0 2 0 0 2 2 2 1 Peptidase S46 Tricorn_PDZ PF14685.6 CDW56064.1 - 0.034 14.1 0.0 0.095 12.7 0.0 1.7 1 0 0 1 1 1 0 Tricorn protease PDZ domain IBN_N PF03810.19 CDW56066.1 - 6.5e-12 45.2 0.0 2.1e-11 43.6 0.0 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 CDW56066.1 - 0.0003 20.9 1.1 0.0017 18.5 0.4 2.5 2 0 0 2 2 2 1 Exportin 1-like protein Cse1 PF08506.10 CDW56066.1 - 0.0056 15.5 0.2 0.014 14.3 0.0 1.7 2 0 0 2 2 2 1 Cse1 DUF5063 PF16702.5 CDW56066.1 - 0.029 14.7 0.1 10 6.5 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5063) Myb_DNA-binding PF00249.31 CDW56068.1 - 8.7e-06 25.8 0.1 1.9e-05 24.8 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDW56068.1 - 0.18 12.1 0.1 0.41 10.9 0.1 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain PDE8 PF08629.10 CDW56068.1 - 8.5 6.5 9.4 41 4.3 0.1 3.8 3 0 0 3 3 3 0 PDE8 phosphodiesterase TAP42 PF04177.12 CDW56069.1 - 1.9e-15 56.8 5.0 3e-15 56.2 5.0 1.3 1 0 0 1 1 1 1 TAP42-like family TFIID-18kDa PF02269.16 CDW56069.1 - 1.5e-07 31.3 0.0 4.9e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Kinesin PF00225.23 CDW56070.1 - 1.7e-89 300.0 0.5 1.7e-89 300.0 0.5 3.9 2 2 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 CDW56070.1 - 5.6e-12 45.8 0.0 5.6e-12 45.8 0.0 4.7 4 1 0 4 4 4 1 Microtubule binding CENP-F_leu_zip PF10473.9 CDW56070.1 - 0.00013 22.0 5.9 0.00013 22.0 5.9 6.6 3 1 4 7 7 7 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Syntaxin-6_N PF09177.11 CDW56070.1 - 0.002 18.6 1.2 0.002 18.6 1.2 6.5 3 1 4 7 7 7 1 Syntaxin 6, N-terminal XhlA PF10779.9 CDW56070.1 - 0.014 15.5 2.7 0.014 15.5 2.7 7.7 5 2 3 8 8 8 0 Haemolysin XhlA FUSC PF04632.12 CDW56070.1 - 3 6.2 21.9 0.085 11.4 10.0 2.5 1 1 1 2 2 2 0 Fusaric acid resistance protein family DUF948 PF06103.11 CDW56070.1 - 6 7.2 43.9 4.2 7.7 2.4 7.9 5 1 2 7 7 7 0 Bacterial protein of unknown function (DUF948) DUF2628 PF10947.8 CDW56071.1 - 0.053 13.9 0.3 0.087 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) AbiEi_1 PF09407.10 CDW56071.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 AbiEi antitoxin C-terminal domain SNAPc_SNAP43 PF09808.9 CDW56072.1 - 1.6e-07 31.5 0.3 4.4e-07 30.0 0.0 1.8 2 0 0 2 2 2 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 SMC_N PF02463.19 CDW56074.1 - 7.1e-63 212.0 0.0 1.1e-61 208.0 0.0 3.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDW56074.1 - 3.4e-24 85.4 0.6 3.5e-23 82.1 0.1 2.9 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CDW56074.1 - 1.1e-14 55.0 3.9 1.6e-06 28.2 0.1 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CDW56074.1 - 5.8e-13 49.3 0.2 5.8e-13 49.3 0.2 4.2 3 1 1 4 4 4 2 AAA ATPase domain AAA_23 PF13476.6 CDW56074.1 - 4.3e-08 33.9 35.1 4.3e-08 33.9 35.1 7.1 3 2 1 4 4 2 1 AAA domain AAA_29 PF13555.6 CDW56074.1 - 3.2e-06 26.8 0.0 6.6e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Laminin_II PF06009.12 CDW56074.1 - 0.00051 20.1 8.6 0.00051 20.1 8.6 7.5 4 3 5 9 9 9 1 Laminin Domain II SbcCD_C PF13558.6 CDW56074.1 - 0.0029 17.8 0.0 0.013 15.8 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Mating_N PF12731.7 CDW56074.1 - 0.091 12.9 4.2 0.63 10.2 1.8 3.0 2 0 0 2 2 2 0 Mating-type protein beta 1 XhlA PF10779.9 CDW56074.1 - 0.14 12.4 0.0 0.14 12.4 0.0 9.4 8 3 3 11 11 10 0 Haemolysin XhlA ABC_tran PF00005.27 CDW56074.1 - 0.2 12.2 0.0 0.2 12.2 0.0 6.6 4 3 0 4 4 2 0 ABC transporter SpoIIE PF07228.12 CDW56075.1 - 1.3e-11 44.8 0.0 1.9e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CDW56075.1 - 2.2e-06 27.5 0.1 0.0023 17.6 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CDW56075.1 - 0.0043 16.7 0.0 0.0063 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C XRN1_DBM PF18245.1 CDW56075.1 - 0.27 11.3 0.9 0.64 10.1 0.9 1.6 1 0 0 1 1 1 0 5-3 exonuclease XRN1 DCP1-binding motif DnaJ PF00226.31 CDW56076.1 - 5.7e-13 48.8 1.9 8e-13 48.3 0.6 1.9 2 0 0 2 2 2 1 DnaJ domain FTHFS PF01268.19 CDW56077.1 - 1.1e-231 769.9 0.0 1.7e-231 769.2 0.0 1.3 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 CDW56077.1 - 2.4e-67 225.2 3.5 3.7e-66 221.4 0.5 2.6 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CDW56077.1 - 9.8e-34 116.1 0.8 2.1e-33 115.0 0.8 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain His_Phos_1 PF00300.22 CDW56078.1 - 3.4e-12 46.5 0.0 1.4e-11 44.4 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Aminotran_5 PF00266.19 CDW56079.1 - 9.6e-82 274.9 0.0 5.3e-81 272.4 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CDW56079.1 - 3.4e-09 36.4 0.0 4.3e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CDW56079.1 - 1.9e-08 33.9 0.0 2.8e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CDW56079.1 - 4.4e-07 29.5 0.0 8.5e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CDW56079.1 - 0.00043 18.9 0.0 0.00065 18.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 CDW56079.1 - 0.01 14.6 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain NIPSNAP PF07978.13 CDW56079.1 - 0.075 13.3 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 NIPSNAP Rib_5-P_isom_A PF06026.14 CDW56081.1 - 1.5e-53 180.9 0.0 1.9e-53 180.6 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CDW56081.1 - 0.00075 19.5 0.0 0.23 11.4 0.0 2.1 2 0 0 2 2 2 2 DeoR C terminal sensor domain Sugar-bind PF04198.13 CDW56081.1 - 0.019 14.1 0.0 0.026 13.7 0.0 1.1 1 0 0 1 1 1 0 Putative sugar-binding domain Mitofilin PF09731.9 CDW56082.1 - 3.5e-76 257.4 16.0 1.4e-75 255.4 16.0 1.9 1 1 0 1 1 1 1 Mitochondrial inner membrane protein Ntox15 PF15604.6 CDW56082.1 - 1.7 8.8 12.9 0.16 12.1 7.4 2.1 2 0 0 2 2 2 0 Novel toxin 15 PilJ PF13675.6 CDW56082.1 - 5.3 7.1 11.2 1.4 9.0 3.3 3.2 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Peptidase_S24 PF00717.23 CDW56083.1 - 2.9e-09 36.7 0.1 5.2e-09 35.9 0.0 1.5 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CDW56083.1 - 1.5e-05 24.8 0.0 0.00019 21.3 0.0 2.3 1 1 1 2 2 2 1 Signal peptidase, peptidase S26 AhpC-TSA_2 PF13911.6 CDW56084.1 - 1e-16 61.0 0.0 1.4e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 CDW56084.1 - 4.2e-05 23.4 0.0 7.2e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDW56084.1 - 0.047 13.4 0.0 0.48 10.1 0.0 2.0 2 0 0 2 2 2 0 Redoxin zf-C4 PF00105.18 CDW56086.1 - 1.8e-09 37.9 5.4 1.8e-09 37.9 5.4 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW56087.1 - 2.7e-19 69.6 0.8 5.1e-19 68.7 0.8 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor R3H PF01424.22 CDW56088.1 - 1e-10 41.4 0.0 2e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 CDW56088.1 - 4.2e-05 23.5 36.3 0.00015 21.7 15.3 12.9 13 1 0 13 13 13 5 NF-X1 type zinc finger WW PF00397.26 CDW56089.1 - 1.2e-15 57.3 0.1 2e-09 37.4 0.1 2.5 2 0 0 2 2 2 2 WW domain Snapin_Pallidin PF14712.6 CDW56089.1 - 7.8 7.0 16.7 0.2 12.1 2.8 4.3 4 0 0 4 4 4 0 Snapin/Pallidin Lig_chan-Glu_bd PF10613.9 CDW56090.1 - 7.2e-40 135.8 0.0 4.3e-39 133.3 0.0 2.2 2 0 0 2 2 2 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.28 CDW56090.1 - 4.4e-22 78.7 0.0 6.8e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.20 CDW56090.1 - 1.6e-20 73.5 0.0 9.1e-20 71.0 0.0 2.3 2 1 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan PF00060.26 CDW56090.1 - 2.1e-17 63.4 0.7 4e-17 62.4 0.7 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel DUF3961 PF13106.6 CDW56090.1 - 0.74 9.5 2.5 2.2 8.0 2.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) Carb_anhydrase PF00194.21 CDW56091.1 - 1.1e-48 166.0 0.0 1.4e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase SprT-like PF10263.9 CDW56092.1 - 8.9e-21 73.9 0.8 1.4e-20 73.2 0.3 1.5 1 1 0 1 1 1 1 SprT-like family zf-Mss51 PF13824.6 CDW56092.1 - 0.11 12.7 0.6 0.2 11.8 0.6 1.5 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 WLM PF08325.10 CDW56092.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 WLM domain Peptidase_M91 PF14891.6 CDW56092.1 - 0.18 12.1 0.0 0.24 11.7 0.0 1.2 1 0 0 1 1 1 0 Effector protein OSTbeta PF15048.6 CDW56093.1 - 0.018 15.2 0.7 0.055 13.6 0.0 1.9 1 1 0 2 2 2 0 Organic solute transporter subunit beta protein HLH PF00010.26 CDW56094.1 - 8.4e-07 28.9 0.0 2.1e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RNase_H2-Ydr279 PF09468.10 CDW56094.1 - 0.0052 17.0 0.1 0.0063 16.7 0.1 1.1 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain HAP1_N PF04849.13 CDW56094.1 - 0.035 13.3 0.1 0.053 12.7 0.1 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region GCSF PF16647.5 CDW56094.1 - 0.056 13.3 0.0 0.072 12.9 0.0 1.2 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor DNA_topoisoIV PF00521.20 CDW56095.1 - 4.3e-125 418.0 0.0 8e-125 417.1 0.0 1.5 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CDW56095.1 - 3.7e-48 163.0 8.3 3.7e-48 163.0 8.3 2.3 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CDW56095.1 - 4.3e-25 88.2 0.4 1.1e-24 86.9 0.4 1.7 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 CDW56095.1 - 5.5e-14 52.6 0.0 1.3e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDW56095.1 - 3.7e-08 33.5 0.1 2.6e-07 30.8 0.0 2.6 2 0 0 2 2 2 1 Toprim domain Pkinase_Tyr PF07714.17 CDW56096.1 - 2.4e-55 187.6 0.2 5.5e-55 186.4 0.2 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW56096.1 - 1.2e-27 97.0 0.1 3.7e-27 95.3 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 CDW56096.1 - 0.019 14.3 0.5 0.084 12.2 0.5 1.9 1 1 0 1 1 1 0 Kinase-like Pkinase PF00069.25 CDW56097.1 - 9.7e-68 228.4 0.0 1.1e-67 228.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56097.1 - 3.9e-25 88.6 0.0 5e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW56097.1 - 4.5e-05 22.9 0.0 0.0001 21.8 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDW56097.1 - 9.5e-05 21.8 0.1 0.00014 21.2 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW56097.1 - 0.00039 20.4 0.1 0.019 14.9 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDW56097.1 - 0.021 14.4 0.0 0.031 13.8 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase eIF-5_eIF-2B PF01873.17 CDW56098.1 - 6.1e-41 139.0 0.1 9.2e-41 138.4 0.1 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 SBP_bac_3 PF00497.20 CDW56099.1 - 3.4e-06 26.6 0.0 0.0016 17.9 0.0 3.0 2 1 1 3 3 3 3 Bacterial extracellular solute-binding proteins, family 3 TSC22 PF01166.18 CDW56100.1 - 0.0061 16.8 1.6 0.017 15.4 1.6 1.7 1 0 0 1 1 1 1 TSC-22/dip/bun family GrpE PF01025.19 CDW56100.1 - 0.011 15.4 1.6 0.02 14.6 1.6 1.5 1 0 0 1 1 1 0 GrpE YabA PF06156.13 CDW56100.1 - 0.066 13.9 3.8 0.19 12.4 3.8 1.8 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 CDW56100.1 - 0.18 12.3 5.3 0.56 10.7 5.3 1.9 1 0 0 1 1 1 0 Cell division protein ZapB Fungal_TACC PF12709.7 CDW56100.1 - 0.28 11.7 3.6 0.64 10.5 3.6 1.6 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins UPF0184 PF03670.13 CDW56100.1 - 0.44 11.0 2.4 1.3 9.4 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) DivIC PF04977.15 CDW56100.1 - 0.68 9.7 2.9 1.6 8.6 2.9 1.6 1 0 0 1 1 1 0 Septum formation initiator EspB_PE PF18625.1 CDW56100.1 - 0.91 10.0 5.9 3.8 8.0 0.3 2.9 2 1 1 3 3 3 0 ESX-1 secreted protein B PE domain UPF0242 PF06785.11 CDW56100.1 - 1.6 8.8 10.6 0.18 11.9 6.1 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DivIVA PF05103.13 CDW56100.1 - 2.5 8.2 10.8 3.9 7.6 1.6 2.3 2 0 0 2 2 2 0 DivIVA protein Fib_alpha PF08702.10 CDW56100.1 - 3.1 8.0 9.8 0.13 12.5 2.0 2.5 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF4817 PF16087.5 CDW56101.1 - 0.077 12.8 0.1 3.1 7.7 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain (DUF4817) COX6B PF02297.17 CDW56101.1 - 3.9 7.8 7.4 0.2 11.9 0.4 2.5 2 1 0 2 2 2 0 Cytochrome oxidase c subunit VIb TRAM_LAG1_CLN8 PF03798.16 CDW56102.1 - 1.3e-41 142.5 28.3 2.3e-41 141.7 28.3 1.4 1 0 0 1 1 1 1 TLC domain Peptidase_M24 PF00557.24 CDW56103.1 - 5.3e-42 143.9 0.0 7.7e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CDW56103.1 - 3.4e-25 88.1 0.0 6.7e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain CS PF04969.16 CDW56103.1 - 0.0022 19.0 0.1 0.0052 17.8 0.1 1.7 1 0 0 1 1 1 1 CS domain COG4 PF08318.12 CDW56104.1 - 1.6e-78 264.1 2.0 2.9e-78 263.3 2.0 1.4 1 1 0 1 1 1 1 COG4 transport protein Sec10 PF07393.11 CDW56104.1 - 3e-06 26.0 3.5 1.1e-05 24.1 0.3 2.3 2 0 0 2 2 2 2 Exocyst complex component Sec10 DIL PF01843.19 CDW56104.1 - 0.098 12.9 0.2 0.31 11.3 0.2 1.8 1 0 0 1 1 1 0 DIL domain VPS9 PF02204.18 CDW56105.1 - 1.7e-27 95.7 0.1 4e-27 94.5 0.1 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain zf-A20 PF01754.16 CDW56105.1 - 6.5e-13 48.4 7.2 1.6e-12 47.1 7.2 1.7 1 0 0 1 1 1 1 A20-like zinc finger DUF5601 PF18151.1 CDW56105.1 - 8.1e-10 38.9 0.0 8.2e-09 35.7 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) ApoO PF09769.9 CDW56105.1 - 0.0023 17.9 0.1 2.7 7.9 0.0 2.4 2 0 0 2 2 2 2 Apolipoprotein O ATG16 PF08614.11 CDW56105.1 - 0.032 14.5 1.2 0.067 13.4 1.2 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) zf-C3HC4_3 PF13920.6 CDW56106.1 - 2.1e-07 30.7 8.1 5.9e-07 29.2 8.1 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW56106.1 - 1.1e-06 28.4 11.3 4e-06 26.6 11.3 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW56106.1 - 3.5e-05 23.7 10.3 0.00011 22.0 10.3 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDW56106.1 - 0.0003 20.6 12.0 0.00072 19.3 10.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW56106.1 - 0.00084 19.2 7.2 0.0021 17.9 7.2 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CDW56106.1 - 0.00085 19.3 6.8 0.0029 17.6 6.8 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CDW56106.1 - 0.0026 17.8 4.3 0.0085 16.1 4.3 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 CDW56106.1 - 0.0037 17.1 2.7 0.01 15.7 2.7 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein TolA_bind_tri PF16331.5 CDW56106.1 - 0.0053 16.8 7.6 0.0053 16.8 7.6 7.6 8 0 0 8 8 8 1 TolA binding protein trimerisation Mrr_cat PF04471.12 CDW56106.1 - 0.01 15.9 2.7 0.031 14.3 0.1 3.1 4 0 0 4 4 4 0 Restriction endonuclease zf-RING_2 PF13639.6 CDW56106.1 - 0.012 16.0 11.0 0.054 13.8 11.2 2.2 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.6 CDW56106.1 - 0.26 11.5 8.1 0.9 9.7 8.1 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ribbon_3 PF13248.6 CDW56106.1 - 0.94 9.0 5.2 2.6 7.6 1.9 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-rbx1 PF12678.7 CDW56106.1 - 1.2 9.4 14.2 0.11 12.8 7.1 3.0 3 1 0 3 3 3 0 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 CDW56106.1 - 4.3 7.3 9.5 11 6.0 8.1 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) AAA PF00004.29 CDW56107.1 - 9.7e-42 142.5 0.1 2.3e-41 141.3 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDW56107.1 - 2.9e-19 68.8 0.0 6.8e-19 67.6 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CDW56107.1 - 2.6e-10 39.9 0.6 7.2e-10 38.5 0.6 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CDW56107.1 - 3.3e-06 27.2 0.9 1.2e-05 25.3 0.1 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDW56107.1 - 1.2e-05 25.1 0.0 3.4e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDW56107.1 - 1.6e-05 25.4 1.5 0.0032 17.9 0.1 2.7 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 CDW56107.1 - 4.1e-05 23.8 0.0 0.00013 22.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDW56107.1 - 8.3e-05 22.9 0.2 0.0092 16.3 0.0 2.6 1 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 CDW56107.1 - 0.00024 20.4 0.0 0.00038 19.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 CDW56107.1 - 0.00064 19.2 0.2 0.0019 17.6 0.1 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDW56107.1 - 0.0018 17.8 0.1 0.0044 16.5 0.1 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 CDW56107.1 - 0.0029 18.1 0.0 0.018 15.6 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_25 PF13481.6 CDW56107.1 - 0.0071 15.9 0.6 0.041 13.5 0.1 2.2 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CDW56107.1 - 0.0082 15.9 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TolA_bind_tri PF16331.5 CDW56107.1 - 0.0093 16.0 2.5 0.029 14.4 0.6 2.4 2 0 0 2 2 2 1 TolA binding protein trimerisation PhoH PF02562.16 CDW56107.1 - 0.013 14.9 0.1 0.041 13.3 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_33 PF13671.6 CDW56107.1 - 0.015 15.5 0.1 0.036 14.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 CDW56107.1 - 0.015 15.1 0.2 0.045 13.5 0.2 1.9 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 CDW56107.1 - 0.016 14.5 0.0 0.031 13.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase PF06745.13 CDW56107.1 - 0.019 14.3 1.2 0.044 13.1 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_3 PF07726.11 CDW56107.1 - 0.023 14.5 0.5 0.33 10.8 0.0 2.7 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CDW56107.1 - 0.024 14.3 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain CPT PF07931.12 CDW56107.1 - 0.032 14.1 0.0 0.084 12.7 0.0 1.7 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NACHT PF05729.12 CDW56107.1 - 0.033 14.1 0.2 0.3 11.0 0.0 2.2 1 1 0 2 2 2 0 NACHT domain AAA_11 PF13086.6 CDW56107.1 - 0.04 13.7 0.5 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CDW56107.1 - 0.042 14.4 0.3 0.26 11.8 0.0 2.3 2 1 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 CDW56107.1 - 0.043 14.2 0.0 0.097 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 CDW56107.1 - 0.049 13.3 0.1 0.15 11.7 0.1 1.8 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 CDW56107.1 - 0.056 12.5 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 GrpE PF01025.19 CDW56107.1 - 0.059 13.0 0.9 0.18 11.4 0.3 2.1 2 0 0 2 2 2 0 GrpE AAA_19 PF13245.6 CDW56107.1 - 0.069 13.5 0.2 0.21 11.9 0.2 1.7 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 CDW56107.1 - 0.08 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 CDW56107.1 - 0.11 12.5 1.0 4.9 7.0 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 CDW56107.1 - 0.13 12.6 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF1192 PF06698.11 CDW56107.1 - 0.14 12.3 1.5 0.38 10.8 1.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Pyridoxal_deC PF00282.19 CDW56108.1 - 7.1e-120 400.1 0.6 1.3e-116 389.4 0.6 3.0 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CDW56108.1 - 0.014 14.7 0.0 0.029 13.7 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase B12D PF06522.11 CDW56108.1 - 0.1 12.4 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit SepSecS PF05889.13 CDW56108.1 - 0.12 11.0 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Aminotran_1_2 PF00155.21 CDW56108.1 - 0.13 11.5 0.0 0.37 9.9 0.0 1.6 2 0 0 2 2 2 0 Aminotransferase class I and II DUF2040 PF09745.9 CDW56110.1 - 9.8e-32 109.6 18.3 9.8e-32 109.6 18.3 3.1 2 1 1 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) Cir_Bir_Yir PF06022.11 CDW56110.1 - 0.13 11.7 0.7 0.22 11.0 0.7 1.4 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir COMPASS-Shg1 PF05205.12 CDW56111.1 - 0.046 14.4 0.9 0.076 13.7 0.9 1.4 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 PetM PF08041.11 CDW56111.1 - 0.18 11.4 2.4 4.2 7.0 0.5 2.9 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 E1_dh PF00676.20 CDW56112.1 - 7.1e-88 294.4 0.0 9.2e-88 294.0 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component ANAPC10 PF03256.16 CDW56112.1 - 5.7e-57 192.4 0.1 9.4e-57 191.6 0.1 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Transketolase_N PF00456.21 CDW56112.1 - 0.00026 20.1 0.0 0.00039 19.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.6 CDW56112.1 - 0.0052 16.0 0.0 0.016 14.5 0.0 1.7 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 CDW56112.1 - 0.056 13.2 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain EF-hand_1 PF00036.32 CDW56113.1 - 2.6e-18 64.1 13.3 0.0013 18.1 0.1 5.8 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 CDW56113.1 - 2.3e-15 56.8 18.9 3.5e-08 33.8 1.1 3.7 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CDW56113.1 - 6.4e-15 53.7 13.9 0.00024 20.8 0.4 5.5 5 0 0 5 5 5 5 EF-hand domain EF-hand_5 PF13202.6 CDW56113.1 - 5.4e-12 44.6 15.0 0.006 16.0 0.1 5.3 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 CDW56113.1 - 2.1e-07 30.7 14.9 0.35 10.8 0.3 5.9 5 1 1 6 6 6 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW56113.1 - 0.00036 20.8 15.8 0.037 14.3 2.4 3.2 1 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region DSPc PF00782.20 CDW56114.1 - 3.8e-08 33.2 0.0 6.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain HigB_toxin PF09907.9 CDW56114.1 - 0.042 14.1 0.1 0.13 12.5 0.1 1.9 1 0 0 1 1 1 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system Y_phosphatase PF00102.27 CDW56114.1 - 0.071 12.7 0.0 0.097 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase TBD PF12845.7 CDW56114.1 - 0.11 12.4 0.2 0.27 11.2 0.2 1.7 1 0 0 1 1 1 0 TBD domain RRM_1 PF00076.22 CDW56115.1 - 1e-21 76.5 0.0 4.1e-05 23.3 0.0 4.8 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 CDW56115.1 - 0.006 16.8 0.1 16 5.7 0.0 3.7 4 0 0 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter Pkinase PF00069.25 CDW56116.1 - 4.1e-65 219.8 0.0 5.1e-65 219.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56116.1 - 2.8e-32 112.0 0.0 3.7e-32 111.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 CDW56116.1 - 5.5e-14 51.8 5.9 1.2e-13 50.7 5.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PB1 PF00564.24 CDW56116.1 - 5e-08 32.8 0.0 1.3e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 PB1 domain Kinase-like PF14531.6 CDW56116.1 - 3.9e-05 23.1 0.0 0.00017 21.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 CDW56116.1 - 7.8e-05 23.3 1.9 0.00016 22.3 1.9 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CDW56116.1 - 0.0027 16.7 0.0 0.0038 16.2 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 CDW56116.1 - 0.014 15.0 0.2 0.42 10.2 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 C1_2 PF03107.16 CDW56116.1 - 0.016 15.5 1.5 0.034 14.4 1.5 1.5 1 0 0 1 1 1 0 C1 domain APH PF01636.23 CDW56116.1 - 0.049 13.5 0.1 0.45 10.4 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family PHD PF00628.29 CDW56116.1 - 0.12 12.3 4.9 0.23 11.4 4.9 1.4 1 0 0 1 1 1 0 PHD-finger PHD_2 PF13831.6 CDW56116.1 - 0.13 11.9 3.4 0.26 10.9 3.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 CDW56116.1 - 5.4 7.4 7.0 12 6.3 7.0 1.6 1 0 0 1 1 1 0 RING-like domain Glyco_transf_21 PF13506.6 CDW56117.1 - 3.8e-50 169.7 0.1 5.5e-50 169.2 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 CDW56117.1 - 2e-20 73.7 0.0 2.6e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CDW56117.1 - 2.5e-13 50.4 2.2 2.5e-13 50.4 2.2 2.1 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Na_sulph_symp PF00939.19 CDW56118.1 - 4.6e-81 273.2 9.0 1.7e-80 271.4 9.0 1.7 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CDW56118.1 - 5.9e-38 130.8 29.0 2.5e-23 82.7 7.9 3.2 2 1 1 3 3 3 3 Citrate transporter Hist_deacetyl PF00850.19 CDW56119.1 - 3.7e-09 36.5 0.0 4.6e-09 36.2 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain SK_channel PF03530.14 CDW56120.1 - 3.9e-37 126.7 2.0 3.9e-37 126.7 2.0 2.2 3 0 0 3 3 3 1 Calcium-activated SK potassium channel CaMBD PF02888.16 CDW56120.1 - 3e-24 85.0 4.1 3e-24 85.0 4.1 2.3 3 0 0 3 3 3 1 Calmodulin binding domain Ion_trans_2 PF07885.16 CDW56120.1 - 4.4e-13 49.0 4.7 4.4e-13 49.0 4.7 2.1 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 CDW56120.1 - 0.0057 15.9 3.1 0.0057 15.9 3.1 2.8 3 1 0 3 3 3 1 Ion transport protein Lig_chan PF00060.26 CDW56120.1 - 0.11 12.3 8.2 0.0086 15.9 2.3 2.4 2 1 0 2 2 2 0 Ligand-gated ion channel IRK PF01007.20 CDW56120.1 - 0.18 11.6 4.7 0.59 9.9 4.7 1.9 1 1 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain CAP PF00188.26 CDW56121.1 - 2e-14 54.5 0.1 3.6e-14 53.7 0.1 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PHR PF08005.12 CDW56122.1 - 4.1e-45 154.2 1.1 6.5e-45 153.5 1.1 1.3 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 CDW56122.1 - 2.9e-24 85.4 0.0 1.9e-23 82.8 0.0 2.1 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 CDW56122.1 - 1.6e-07 31.4 4.1 4.9e-07 29.8 3.6 2.2 1 1 1 2 2 2 1 BTB And C-terminal Kelch DUF4082 PF13313.6 CDW56122.1 - 0.092 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) Acetyltransf_13 PF13880.6 CDW56123.1 - 2.6e-21 75.4 0.0 6.9e-21 74.0 0.0 1.7 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 CDW56123.1 - 1.3e-13 50.5 0.1 2.7e-13 49.5 0.1 1.6 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 CDW56123.1 - 0.013 15.9 0.0 0.022 15.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sld5 PF05916.11 CDW56124.1 - 0.0015 18.9 0.1 0.0051 17.3 0.0 1.8 2 0 0 2 2 2 1 GINS complex protein WD40 PF00400.32 CDW56125.1 - 9.9e-14 51.5 11.2 0.0064 17.3 0.3 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56125.1 - 0.00023 21.4 0.0 2.8 8.3 0.0 3.6 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW56125.1 - 0.15 11.0 0.2 0.82 8.6 0.0 2.2 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein AMMECR1 PF01871.17 CDW56126.1 - 4.5e-44 150.0 0.0 8.3e-44 149.1 0.0 1.4 1 0 0 1 1 1 1 AMMECR1 Peptidase_C13 PF01650.18 CDW56127.1 - 7.6e-44 150.1 0.0 9.9e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 CDW56127.1 - 0.016 15.5 0.0 0.073 13.3 0.0 2.0 2 0 0 2 2 2 0 Mid domain of argonaute MMR_HSR1 PF01926.23 CDW56128.1 - 3.2e-16 59.4 0.1 6.5e-16 58.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW56128.1 - 8.7e-08 31.8 0.6 1.4e-07 31.2 0.6 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CDW56128.1 - 6.1e-05 22.5 0.7 0.0001 21.7 0.7 1.3 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 CDW56128.1 - 6.4e-05 23.1 4.0 0.0022 18.1 0.3 2.6 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 CDW56128.1 - 8.5e-05 22.2 0.1 0.003 17.1 0.1 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CDW56128.1 - 8.7e-05 22.5 0.7 0.0084 16.0 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase KH_2 PF07650.17 CDW56128.1 - 0.0011 18.7 0.1 0.0023 17.7 0.1 1.5 1 0 0 1 1 1 1 KH domain SRPRB PF09439.10 CDW56128.1 - 0.0015 18.0 0.1 0.0088 15.5 0.1 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit KTI12 PF08433.10 CDW56128.1 - 0.0092 15.5 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 cobW PF02492.19 CDW56128.1 - 0.076 12.6 0.1 0.14 11.7 0.1 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 CDW56128.1 - 0.079 12.3 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 CDW56129.1 - 4.1e-22 79.1 0.0 8.1e-22 78.2 0.0 1.4 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.6 CDW56129.1 - 1.1e-06 29.1 0.0 4.1e-06 27.2 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 CDW56129.1 - 0.00044 20.7 0.0 0.00088 19.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW56129.1 - 0.0016 18.7 0.0 0.0024 18.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDW56129.1 - 0.0028 17.8 0.0 0.0083 16.3 0.0 1.8 1 1 0 2 2 2 1 AAA domain ADK PF00406.22 CDW56129.1 - 0.0033 17.5 0.0 0.93 9.6 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase AAA_19 PF13245.6 CDW56129.1 - 0.0055 17.0 0.2 0.013 15.8 0.1 1.7 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 CDW56129.1 - 0.0062 16.8 0.1 0.024 14.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 CDW56129.1 - 0.01 15.6 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 CDW56129.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA_16 PF13191.6 CDW56129.1 - 0.014 15.7 0.0 0.02 15.3 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain Thymidylate_kin PF02223.17 CDW56129.1 - 0.018 14.7 0.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase T2SSE PF00437.20 CDW56129.1 - 0.018 14.1 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 CDW56129.1 - 0.032 13.9 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDW56129.1 - 0.038 13.4 0.0 0.057 12.8 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 CDW56129.1 - 0.039 13.3 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF2075 PF09848.9 CDW56129.1 - 0.047 12.9 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CDW56129.1 - 0.084 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 CDW56129.1 - 0.1 12.0 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 CDW56129.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 CDW56129.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 KaiC ComJ PF11033.8 CDW56130.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Competence protein J (ComJ) CH PF00307.31 CDW56131.1 - 7.7e-53 177.3 0.1 1.5e-26 92.7 0.0 3.2 2 0 0 2 2 2 2 Calponin homology (CH) domain Spectrin PF00435.21 CDW56131.1 - 3.8e-47 159.1 24.7 1.1e-18 67.6 2.1 4.4 4 0 0 4 4 4 4 Spectrin repeat EFhand_Ca_insen PF08726.10 CDW56131.1 - 2.8e-24 85.0 0.0 1.1e-23 83.1 0.0 2.2 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 CDW56131.1 - 1.6e-10 40.7 0.0 1.7e-09 37.4 0.1 2.4 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_1 PF00036.32 CDW56131.1 - 0.0024 17.3 0.2 0.018 14.6 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 CDW56131.1 - 0.0081 16.0 0.0 0.031 14.1 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain pair DUF349 PF03993.12 CDW56131.1 - 0.028 14.7 0.0 0.028 14.7 0.0 4.3 4 1 1 5 5 4 0 Domain of Unknown Function (DUF349) EF-hand_6 PF13405.6 CDW56131.1 - 0.14 12.2 0.6 15 5.8 0.1 3.6 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 CDW56131.1 - 0.26 11.8 1.9 0.64 10.5 0.1 2.8 3 0 0 3 3 2 0 EF-hand domain pair E_Pc_C PF06752.12 CDW56131.1 - 0.27 11.3 1.8 0.47 10.5 1.8 1.3 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus 23S_rRNA_IVP PF05635.11 CDW56131.1 - 0.55 10.6 4.7 2.3 8.6 0.1 4.0 4 2 1 5 5 5 0 23S rRNA-intervening sequence protein VPS11_C PF12451.8 CDW56131.1 - 0.87 9.9 9.5 38 4.6 0.2 4.5 4 0 0 4 4 4 0 Vacuolar protein sorting protein 11 C terminal DSPc PF00782.20 CDW56133.1 - 6.9e-33 113.3 0.2 1e-32 112.7 0.2 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CDW56133.1 - 1.6e-05 24.6 0.0 2.1e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 CDW56133.1 - 0.0018 18.5 0.0 0.0042 17.4 0.0 1.7 1 1 0 1 1 1 1 Rit1 DUSP-like domain Spc42p PF11544.8 CDW56134.1 - 0.015 15.3 0.5 0.015 15.3 0.5 2.2 2 1 0 2 2 2 0 Spindle pole body component Spc42p TMF_DNA_bd PF12329.8 CDW56134.1 - 0.021 14.8 1.5 0.021 14.8 1.5 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding PKcGMP_CC PF16808.5 CDW56134.1 - 0.037 13.9 8.4 0.28 11.1 5.6 2.9 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SapC PF07277.11 CDW56135.1 - 0.27 10.8 0.0 0.27 10.8 0.0 2.0 3 0 0 3 3 3 0 SapC DUF4164 PF13747.6 CDW56135.1 - 1.5 9.2 6.3 6.9 7.0 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Jnk-SapK_ap_N PF09744.9 CDW56135.1 - 9.4 6.4 18.8 1.7 8.8 7.7 2.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Nup160 PF11715.8 CDW56136.1 - 5.8e-21 74.7 2.5 8.1e-21 74.3 2.5 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 WD40_3 PF15911.5 CDW56137.1 - 3.3e-07 30.2 0.0 1.7e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF1132 PF06575.12 CDW56137.1 - 0.13 12.7 1.6 1.5 9.3 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1132) Coatomer_WDAD PF04053.14 CDW56137.1 - 0.27 10.2 7.1 0.036 13.1 0.7 2.8 4 0 0 4 4 4 0 Coatomer WD associated region TPR_12 PF13424.6 CDW56137.1 - 1.6 9.1 19.9 6.6 7.1 0.1 6.3 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDW56137.1 - 9.1 6.7 32.7 0.12 12.5 0.2 7.9 8 0 0 8 8 8 0 Tetratricopeptide repeat 7TM_GPCR_Srx PF10328.9 CDW56139.1 - 1.9e-29 103.1 36.8 2.6e-29 102.6 36.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 CDW56139.1 - 3e-13 49.7 34.6 6e-13 48.7 34.6 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srt PF10321.9 CDW56139.1 - 4.4e-08 32.5 33.8 6.4e-08 31.9 33.8 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srt zf-U1 PF06220.12 CDW56139.1 - 0.056 13.2 0.4 0.14 11.9 0.4 1.6 1 0 0 1 1 1 0 U1 zinc finger LUC7 PF03194.15 CDW56140.1 - 3.8e-75 252.8 5.5 4.2e-75 252.7 5.5 1.0 1 0 0 1 1 1 1 LUC7 N_terminus CPSase_L_D3 PF02787.19 CDW56140.1 - 0.049 14.0 1.0 0.076 13.4 1.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Spc7 PF08317.11 CDW56140.1 - 0.1 11.5 8.1 0.15 10.9 8.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Ras PF00071.22 CDW56141.1 - 3.6e-47 160.0 0.0 4.3e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW56141.1 - 1e-29 103.2 0.0 2.7e-29 101.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW56141.1 - 8.7e-10 38.3 0.0 1.2e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 CDW56141.1 - 0.00086 19.7 0.1 0.01 16.2 0.1 2.1 1 1 0 1 1 1 1 RNA helicase GTP_EFTU PF00009.27 CDW56141.1 - 0.0077 15.8 0.1 0.02 14.5 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDW56141.1 - 0.01 15.2 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDW56141.1 - 0.029 14.3 0.0 2.7 7.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase ArgoMid PF16487.5 CDW56141.1 - 0.031 14.5 0.0 0.066 13.5 0.0 1.5 1 1 0 1 1 1 0 Mid domain of argonaute AAA_7 PF12775.7 CDW56141.1 - 0.062 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 CDW56141.1 - 0.076 12.8 0.2 10 5.8 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Pox_A32 PF04665.12 CDW56141.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.20 CDW56141.1 - 0.39 9.8 1.7 7.8 5.5 0.1 2.4 2 1 1 3 3 3 0 G-protein alpha subunit zf-C2H2 PF00096.26 CDW56142.1 - 5.6e-28 95.8 28.6 4e-06 27.0 0.8 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW56142.1 - 3.6e-22 77.1 25.0 0.00031 21.3 1.0 5.9 6 0 0 6 6 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW56142.1 - 6.4e-22 76.9 24.7 4.2e-07 30.1 0.5 6.5 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2_6 PF13912.6 CDW56142.1 - 1.3e-11 44.2 26.7 0.0097 15.9 1.9 5.8 5 1 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW56142.1 - 2.3e-08 34.1 19.0 0.099 13.0 0.2 5.5 5 0 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 CDW56142.1 - 5.3e-05 22.9 26.7 0.041 13.6 1.6 6.2 6 0 0 6 6 6 3 zinc-finger C2H2-type zf_UBZ PF18439.1 CDW56142.1 - 0.00045 19.8 10.2 5.7 6.6 0.1 5.3 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 CDW56142.1 - 0.00077 19.5 15.0 0.12 12.5 1.7 4.1 2 1 3 5 5 5 3 Zinc ribbon domain zf-BED PF02892.15 CDW56142.1 - 0.0026 17.7 26.1 0.34 11.0 2.0 5.1 2 1 1 3 3 3 1 BED zinc finger XPA_N PF01286.18 CDW56142.1 - 0.0029 17.6 13.6 2.7 8.1 0.3 5.1 5 0 0 5 5 5 1 XPA protein N-terminal zf-met PF12874.7 CDW56142.1 - 0.003 17.9 25.2 0.042 14.2 0.2 5.4 6 0 0 6 6 5 2 Zinc-finger of C2H2 type zf-Di19 PF05605.12 CDW56142.1 - 0.0032 17.7 16.2 0.43 10.9 2.9 3.6 1 1 2 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 CDW56142.1 - 0.018 15.8 14.5 0.18 12.6 0.8 2.9 2 1 0 2 2 2 0 zinc-ribbon family HypA PF01155.19 CDW56142.1 - 0.02 14.9 12.9 0.22 11.5 0.9 3.2 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HE PF16278.5 CDW56142.1 - 0.032 14.7 15.7 0.83 10.1 0.3 4.4 2 2 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger NapB PF03892.14 CDW56142.1 - 0.043 13.8 3.8 3.1 7.8 0.7 2.9 3 0 0 3 3 3 0 Nitrate reductase cytochrome c-type subunit (NapB) ADK_lid PF05191.14 CDW56142.1 - 0.046 13.7 13.3 0.78 9.8 0.9 3.7 3 1 1 4 4 4 0 Adenylate kinase, active site lid FYVE PF01363.21 CDW56142.1 - 0.071 13.3 19.0 0.88 9.8 4.6 3.6 1 1 2 3 3 3 0 FYVE zinc finger zf-C2H2_3rep PF18868.1 CDW56142.1 - 0.64 10.7 10.3 6.6 7.4 0.1 3.5 2 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-LYAR PF08790.11 CDW56142.1 - 0.69 9.9 12.0 10 6.1 0.2 4.9 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger zf-AN1 PF01428.16 CDW56142.1 - 0.71 10.1 16.8 28 5.0 0.1 5.2 5 0 0 5 5 5 0 AN1-like Zinc finger C1_4 PF07975.12 CDW56142.1 - 0.83 9.9 16.0 0.094 13.0 2.1 3.4 2 1 1 3 3 3 0 TFIIH C1-like domain Rpr2 PF04032.16 CDW56142.1 - 1.3 9.3 14.6 6.1 7.2 1.9 2.8 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2H2_2 PF12756.7 CDW56142.1 - 1.4 9.3 20.9 7.7 6.9 6.6 4.0 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) DZR PF12773.7 CDW56142.1 - 1.5 8.9 19.8 1.8e+04 -5.0 19.8 3.4 1 1 0 1 1 0 0 Double zinc ribbon DUF3268 PF11672.8 CDW56142.1 - 1.9 8.8 9.0 1.5 9.2 1.1 2.5 2 0 0 2 2 2 0 zinc-finger-containing domain Zn-C2H2_12 PF18112.1 CDW56142.1 - 4.6 7.8 5.8 41 4.8 0.1 4.0 4 1 0 4 4 3 0 Autophagy receptor zinc finger-C2H2 domain DUF2256 PF10013.9 CDW56142.1 - 5.2 7.3 12.0 19 5.5 0.0 4.7 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_7 PF15269.6 CDW56142.1 - 5.7 7.1 10.1 23 5.2 2.8 3.5 2 1 1 3 3 3 0 Zinc-finger zinc-ribbons_6 PF07191.12 CDW56142.1 - 6.9 6.7 18.3 12 6.0 3.1 4.4 2 1 1 3 3 3 0 zinc-ribbons CpXC PF14353.6 CDW56142.1 - 9.1 6.4 17.4 2.8 8.0 0.3 4.6 1 1 4 5 5 5 0 CpXC protein Zn_Tnp_IS1595 PF12760.7 CDW56142.1 - 9.5 6.3 23.6 9.4 6.3 0.1 4.1 2 1 2 4 4 4 0 Transposase zinc-ribbon domain YhfH PF14149.6 CDW56142.1 - 9.9 6.2 16.6 2.5 8.1 0.2 4.6 5 0 0 5 5 5 0 YhfH-like protein Asp PF00026.23 CDW56143.1 - 8.4e-66 222.5 0.2 4.6e-31 108.4 0.1 4.1 2 1 2 4 4 4 4 Eukaryotic aspartyl protease TAXi_N PF14543.6 CDW56143.1 - 9.5e-07 29.2 0.0 8.3e-05 22.9 0.0 2.6 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CDW56143.1 - 0.00074 19.3 0.0 0.96 9.2 0.0 2.3 2 0 0 2 2 2 2 Xylanase inhibitor C-terminal Zona_pellucida PF00100.23 CDW56144.1 - 3.5e-13 49.9 4.5 3.5e-13 49.9 4.5 1.7 2 0 0 2 2 2 1 Zona pellucida-like domain Asp PF00026.23 CDW56145.1 - 3.5e-08 33.2 0.1 5e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CDW56145.1 - 0.00015 22.1 0.0 0.00022 21.5 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal CAF1 PF04857.20 CDW56146.1 - 1.4e-16 60.6 0.1 1.7e-07 30.7 0.2 2.8 2 1 0 2 2 2 2 CAF1 family ribonuclease Pro_isomerase PF00160.21 CDW56147.1 - 2.7e-31 109.0 0.0 4.1e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 CDW56147.1 - 6.1e-14 51.6 0.1 1.6e-13 50.3 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW56147.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RMI1_N PF08585.12 CDW56148.1 - 4.6e-08 33.1 0.0 3.4e-06 27.0 0.0 2.2 1 1 1 2 2 2 2 RecQ mediated genome instability protein BRCA-2_OB1 PF09103.10 CDW56148.1 - 0.056 13.4 0.0 0.073 13.0 0.0 1.2 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 zf-rbx1 PF12678.7 CDW56149.1 - 4.8e-61 202.9 49.7 9.5e-23 80.3 11.1 3.2 3 0 0 3 3 3 3 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDW56149.1 - 2.6e-44 149.2 39.1 8.4e-15 54.6 8.0 3.1 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CDW56149.1 - 6.5e-09 36.0 54.9 0.00048 20.4 12.7 5.8 3 3 0 3 3 3 3 Ring finger domain zf-C3HC4_2 PF13923.6 CDW56149.1 - 7e-05 22.6 2.2 7e-05 22.6 2.2 5.9 6 0 0 6 6 6 3 Zinc finger, C3HC4 type (RING finger) YbjN PF10722.9 CDW56149.1 - 0.00013 22.0 0.9 2.2 8.3 0.0 3.4 3 1 0 3 3 3 2 Putative bacterial sensory transduction regulator zf-RING_11 PF17123.5 CDW56149.1 - 0.00058 19.6 18.2 0.012 15.3 1.2 5.9 6 0 0 6 6 6 3 RING-like zinc finger Eaf7 PF07904.13 CDW56149.1 - 0.00079 19.8 0.1 8.7 6.8 0.0 3.3 3 0 0 3 3 3 1 Chromatin modification-related protein EAF7 zf-C3HC4 PF00097.25 CDW56149.1 - 0.0042 16.9 46.1 0.18 11.7 9.8 5.6 3 3 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) MutS_V PF00488.21 CDW56149.1 - 0.017 15.2 0.3 2.3 8.2 0.0 2.7 1 1 2 3 3 3 0 MutS domain V HTH_Tnp_Tc3_1 PF11427.8 CDW56149.1 - 0.026 14.4 3.9 13 5.7 0.1 3.3 3 0 0 3 3 3 0 Tc3 transposase FANCL_C PF11793.8 CDW56149.1 - 0.066 13.4 36.6 1.6 8.9 7.1 4.4 3 3 1 4 4 4 0 FANCL C-terminal domain zf-Nse PF11789.8 CDW56149.1 - 0.1 12.4 7.8 5.1 7.0 0.3 3.5 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit VSP PF03302.13 CDW56149.1 - 0.21 10.4 23.6 0.063 12.1 0.8 3.2 2 1 1 3 3 3 0 Giardia variant-specific surface protein zf-RING_14 PF17978.1 CDW56149.1 - 0.23 11.9 17.2 0.16 12.4 0.9 3.2 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain PP-binding PF00550.25 CDW56150.1 - 7e-11 42.3 0.1 1.1e-10 41.7 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CDW56150.1 - 0.0021 18.3 0.0 0.0031 17.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-carrier PAN_1 PF00024.26 CDW56151.1 - 2.6e-43 145.9 41.2 1.5e-10 40.9 1.8 6.5 6 0 0 6 6 6 6 PAN domain DNA_pol3_a_NII PF11490.8 CDW56151.1 - 0.62 10.0 0.0 0.62 10.0 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II SBP_bac_8 PF13416.6 CDW56152.1 - 0.038 13.8 0.0 0.094 12.5 0.0 1.7 1 1 1 2 2 2 0 Bacterial extracellular solute-binding protein BAR PF03114.18 CDW56153.1 - 2.5e-11 43.7 3.2 3.4e-11 43.3 3.2 1.2 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 CDW56153.1 - 7.7e-06 25.8 3.9 8.6e-05 22.4 2.2 2.2 1 1 1 2 2 2 1 BAR domain of APPL family FAM184 PF15665.5 CDW56153.1 - 0.031 14.0 3.3 0.056 13.2 3.3 1.4 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B ATP-synt_F6 PF05511.11 CDW56153.1 - 0.047 14.1 3.0 0.26 11.7 0.3 2.5 2 1 1 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 Glyco_hydro_65m PF03632.15 CDW56153.1 - 0.14 11.0 0.9 0.16 10.8 0.9 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain RecG_N PF17190.4 CDW56153.1 - 0.17 12.6 3.0 3.9 8.3 0.0 2.8 1 1 2 3 3 3 0 RecG N-terminal helical domain RRM_1 PF00076.22 CDW56154.1 - 2.6e-38 129.7 0.0 4.7e-19 68.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW56154.1 - 7.5e-08 32.4 0.1 0.001 19.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 CDW56154.1 - 7.6e-07 28.8 0.0 0.00058 19.5 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 CDW56154.1 - 0.0028 17.3 0.6 0.15 11.8 0.1 2.4 2 0 0 2 2 2 1 Ribonuclease B OB domain AcetylCoA_hyd_C PF13336.6 CDW56155.1 - 1.9e-48 164.3 0.0 5.7e-48 162.8 0.0 1.7 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 CDW56155.1 - 9.2e-18 64.9 0.0 1.7e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain RabGAP-TBC PF00566.18 CDW56156.1 - 4.4e-22 78.8 2.9 6.8e-22 78.2 2.9 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pur_DNA_glyco PF02245.16 CDW56157.1 - 5e-58 195.4 0.0 6.3e-58 195.1 0.0 1.1 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) STT3 PF02516.14 CDW56158.1 - 2.2e-42 145.7 8.5 3.7e-38 131.7 4.9 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit HRG PF16954.5 CDW56158.1 - 0.98 9.9 8.6 1.5 9.3 1.5 3.2 2 1 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Arf PF00025.21 CDW56160.1 - 1.4e-50 171.2 0.2 1.5e-50 171.0 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW56160.1 - 7e-09 35.9 0.2 1e-08 35.4 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDW56160.1 - 1.1e-08 34.8 0.1 1.3e-08 34.6 0.1 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CDW56160.1 - 1.8e-06 27.4 0.6 4e-06 26.2 0.6 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 CDW56160.1 - 0.00012 21.6 0.1 0.00014 21.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDW56160.1 - 0.00063 19.2 0.0 0.00075 19.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDW56160.1 - 0.059 13.4 0.0 0.087 12.9 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase FragX_IP PF05994.11 CDW56161.1 - 0.28 9.2 0.0 0.37 8.8 0.0 1.0 1 0 0 1 1 1 0 Cytoplasmic Fragile-X interacting family RhoGAP PF00620.27 CDW56162.1 - 3.7e-46 156.7 1.9 1.6e-45 154.6 0.2 2.8 3 1 0 3 3 3 1 RhoGAP domain PH PF00169.29 CDW56162.1 - 3.4e-09 37.2 0.1 6.9e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 CDW56162.1 - 1.9e-08 34.7 0.1 4e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CAP_N PF01213.19 CDW56162.1 - 2.2 7.7 6.8 3.9 6.9 6.8 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Prefoldin PF02996.17 CDW56163.1 - 7.1e-22 77.6 0.2 9.7e-22 77.1 0.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 CDW56163.1 - 2.1e-05 24.4 2.9 6.9e-05 22.8 0.3 2.2 1 1 0 2 2 2 1 Prefoldin subunit DUF4618 PF15397.6 CDW56163.1 - 0.0084 15.6 2.2 0.12 11.8 0.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4618) CdvA PF18822.1 CDW56163.1 - 0.016 15.1 3.0 0.66 9.8 0.2 2.1 2 0 0 2 2 2 0 CdvA-like coiled-coil domain PI3K_P85_iSH2 PF16454.5 CDW56163.1 - 0.025 14.2 1.6 0.04 13.5 1.6 1.3 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF1664 PF07889.12 CDW56163.1 - 0.051 13.6 1.0 0.16 12.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 CDW56163.1 - 0.065 14.0 0.8 14 6.4 0.1 2.2 2 0 0 2 2 2 0 Occludin homology domain DUF2205 PF10224.9 CDW56163.1 - 0.14 12.2 3.1 1.1 9.3 0.1 2.2 2 0 0 2 2 2 0 Short coiled-coil protein DUF1515 PF07439.11 CDW56163.1 - 0.58 10.2 2.7 0.45 10.6 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) VWA_2 PF13519.6 CDW56164.1 - 0.00021 21.9 0.0 0.00039 21.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 CDW56164.1 - 0.00033 20.1 0.1 0.0075 15.7 0.2 2.0 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein VWA_3 PF13768.6 CDW56164.1 - 0.02 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain VWA PF00092.28 CDW56164.1 - 0.024 14.9 0.1 0.057 13.7 0.0 1.6 2 0 0 2 2 2 0 von Willebrand factor type A domain Thioredoxin_6 PF13848.6 CDW56165.1 - 6.7e-35 120.7 0.2 2.4e-34 118.9 0.1 1.8 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.20 CDW56165.1 - 0.00057 19.8 0.0 0.0056 16.6 0.0 2.3 2 1 0 2 2 2 1 Thioredoxin AAA_12 PF13087.6 CDW56166.1 - 1.9e-42 145.1 0.0 3e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain Dna2 PF08696.11 CDW56166.1 - 5.7e-19 68.7 0.0 1.1e-18 67.8 0.0 1.4 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_11 PF13086.6 CDW56166.1 - 1.6e-18 67.4 4.7 1.3e-13 51.4 0.3 2.4 1 1 1 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CDW56166.1 - 3.5e-10 40.0 0.2 1.3e-05 25.1 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 CDW56166.1 - 3.6e-05 23.6 0.0 6.5e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDW56166.1 - 0.00026 21.3 1.0 0.0063 16.9 0.3 2.8 2 1 0 2 2 2 1 AAA domain UvrD_C PF13361.6 CDW56166.1 - 0.019 14.4 0.0 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 CDW56166.1 - 0.11 12.4 0.0 0.32 10.8 0.0 1.9 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain PDDEXK_1 PF12705.7 CDW56166.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily GST_C_2 PF13410.6 CDW56167.1 - 0.00014 21.8 0.0 0.00027 20.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDW56167.1 - 0.02 15.0 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DHR-2 PF06920.13 CDW56168.1 - 2.7e-187 623.6 2.7 4.1e-187 623.0 2.7 1.3 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 CDW56168.1 - 4.6e-36 124.5 0.0 8.1e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 CDW56168.1 - 1.4e-11 44.8 0.8 5.2e-11 43.0 0.8 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) Ribosomal_L27 PF01016.19 CDW56169.1 - 0.0004 20.3 0.0 0.00061 19.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein AA_permease PF00324.21 CDW56170.1 - 8.2e-70 235.7 27.3 3.6e-44 151.2 5.6 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 CDW56170.1 - 2.5e-44 152.0 8.3 1.2e-14 54.2 0.6 3.2 2 1 1 3 3 3 3 Solute carrier family 12 AA_permease_2 PF13520.6 CDW56170.1 - 4e-21 75.4 33.1 5.2e-20 71.7 33.1 2.1 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW56171.1 - 7.7e-58 196.2 30.7 1.2e-38 132.9 7.1 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 CDW56171.1 - 5.9e-32 111.2 1.9 2.8e-13 49.7 0.1 3.1 2 1 1 3 3 3 3 Solute carrier family 12 WD40 PF00400.32 CDW56172.1 - 3.2e-37 125.9 15.7 3.7e-06 27.6 0.2 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat PFU PF09070.11 CDW56172.1 - 3.5e-33 114.2 0.0 8.4e-33 113.0 0.0 1.7 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 CDW56172.1 - 1.7e-27 96.4 0.3 2.4e-27 95.9 0.3 1.2 1 0 0 1 1 1 1 PUL domain BBS2_Mid PF14783.6 CDW56172.1 - 0.0043 17.1 0.0 58 3.8 0.0 4.3 3 1 2 5 5 5 0 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 CDW56172.1 - 0.012 15.9 0.0 4.4 7.7 0.0 3.9 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW56172.1 - 0.034 12.8 0.0 0.23 10.0 0.1 2.3 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Pkinase PF00069.25 CDW56173.1 - 6.3e-60 202.8 0.2 3.8e-59 200.2 0.0 2.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56173.1 - 4.7e-30 104.7 0.2 2.5e-29 102.3 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase C1_1 PF00130.22 CDW56173.1 - 2.7e-06 27.2 1.9 5.7e-06 26.1 1.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 CDW56173.1 - 1.6e-05 25.4 0.1 0.0032 17.9 0.0 3.1 2 0 0 2 2 2 1 PH domain Rho_Binding PF08912.11 CDW56173.1 - 5.6e-05 23.9 12.7 5.6e-05 23.9 12.7 10.2 7 3 4 11 11 11 1 Rho Binding Pkinase_C PF00433.24 CDW56173.1 - 0.007 17.0 1.0 0.022 15.5 1.0 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain OMPdecase PF00215.24 CDW56174.1 - 5.6e-35 121.0 0.3 1.8e-34 119.3 0.3 1.7 1 1 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 CDW56174.1 - 0.035 13.6 0.0 0.087 12.3 0.0 1.7 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Oxysterol_BP PF01237.18 CDW56175.1 - 1.7e-54 185.1 0.0 3.5e-54 184.1 0.0 1.4 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 CDW56175.1 - 2.3e-08 34.5 0.0 5.8e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CDW56175.1 - 2.2e-06 27.9 0.0 5.7e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 CDW56175.1 - 0.019 15.2 0.0 0.045 14.0 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 CDW56175.1 - 0.076 13.4 0.2 3.8 8.0 0.2 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain WD40 PF00400.32 CDW56176.1 - 7.7e-06 26.5 3.6 0.038 14.9 0.1 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat Vps51 PF08700.11 CDW56177.1 - 3e-19 68.9 6.6 3e-19 68.9 6.6 2.5 1 1 1 2 2 2 1 Vps51/Vps67 Sec5 PF15469.6 CDW56177.1 - 2.1e-18 66.8 9.3 3.2e-18 66.2 7.8 2.1 2 1 0 2 2 2 1 Exocyst complex component Sec5 Vps54_N PF10475.9 CDW56177.1 - 3.3e-08 33.2 12.6 8.6e-08 31.8 12.6 1.7 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Dor1 PF04124.12 CDW56177.1 - 9.6e-08 31.1 11.1 2.3e-07 29.8 11.1 1.7 1 1 0 1 1 1 1 Dor1-like family COG2 PF06148.11 CDW56177.1 - 4.5e-07 30.0 4.0 4.5e-07 30.0 4.0 2.5 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps53_N PF04100.12 CDW56177.1 - 0.00041 19.4 9.5 0.001 18.1 9.5 1.7 1 0 0 1 1 1 1 Vps53-like, N-terminal TMF_TATA_bd PF12325.8 CDW56177.1 - 0.0031 17.7 4.1 0.0031 17.7 4.1 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF4304 PF14137.6 CDW56177.1 - 0.087 13.0 0.4 21 5.3 0.0 3.0 3 0 0 3 3 2 0 Domain of unknown function (DUF4304) LOH1CR12 PF10158.9 CDW56177.1 - 0.1 12.6 3.0 0.24 11.4 0.5 2.7 1 1 1 2 2 2 0 Tumour suppressor protein Dzip-like_N PF13815.6 CDW56177.1 - 0.19 11.7 4.2 1.5 8.9 0.0 3.5 3 0 0 3 3 3 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF2884 PF11101.8 CDW56177.1 - 0.21 11.1 6.5 0.24 10.9 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) COG5 PF10392.9 CDW56177.1 - 0.64 10.2 12.2 0.068 13.3 5.6 2.7 2 1 1 3 3 3 0 Golgi transport complex subunit 5 Occludin_ELL PF07303.13 CDW56177.1 - 1.8 9.3 7.2 1.2 9.9 0.5 3.1 2 1 1 3 3 3 0 Occludin homology domain FapA PF03961.13 CDW56177.1 - 5.4 5.5 5.9 5.8 5.4 4.9 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A Cadherin PF00028.17 CDW56178.1 - 2.3e-08 34.3 0.0 0.0011 19.4 0.0 2.4 2 0 0 2 2 2 2 Cadherin domain Cadherin PF00028.17 CDW56179.1 - 2.7e-161 524.6 20.7 1.1e-14 54.6 0.0 15.5 15 0 0 15 15 15 15 Cadherin domain Cadherin_C PF01049.17 CDW56179.1 - 3.9e-32 111.6 0.0 1e-31 110.2 0.0 1.8 1 0 0 1 1 1 1 Cadherin cytoplasmic region Laminin_G_2 PF02210.24 CDW56179.1 - 7e-31 107.4 0.0 6.3e-19 68.8 0.0 2.8 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 CDW56179.1 - 2.8e-21 76.1 0.0 2e-16 60.4 0.0 2.6 2 0 0 2 2 2 2 Laminin G domain RET_CLD1 PF17756.1 CDW56179.1 - 2e-14 53.9 0.0 0.0044 17.3 0.0 8.8 10 0 0 10 10 10 2 RET Cadherin like domain 1 Cadherin_2 PF08266.12 CDW56179.1 - 2.6e-10 40.0 0.5 2.3 8.1 0.0 6.9 7 0 0 7 7 7 3 Cadherin-like Cadherin_pro PF08758.11 CDW56179.1 - 3.6e-07 30.3 0.6 1.4 9.2 0.0 5.9 6 1 0 6 6 6 1 Cadherin prodomain like Cadherin_3 PF16184.5 CDW56179.1 - 5.7e-07 29.5 21.4 2.9 7.9 0.1 10.1 11 0 0 11 11 11 2 Cadherin-like hEGF PF12661.7 CDW56179.1 - 0.00024 21.6 29.0 0.011 16.3 3.3 4.8 4 0 0 4 4 4 2 Human growth factor-like EGF EGF PF00008.27 CDW56179.1 - 0.014 15.7 41.8 0.022 15.1 3.3 4.7 4 1 0 4 4 4 0 EGF-like domain Cadherin_4 PF17803.1 CDW56179.1 - 0.027 15.1 28.4 0.42 11.3 0.2 8.6 8 0 0 8 8 8 0 Bacterial cadherin-like domain Pkinase PF00069.25 CDW56180.1 - 5.5e-07 29.2 0.0 7.7e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56180.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase FSA_C PF10479.9 CDW56181.1 - 4e-62 210.4 4.3 3e-50 171.2 0.9 3.3 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus Granulin PF00396.18 CDW56182.1 - 1.9e-16 60.1 22.7 1.9e-16 60.1 22.7 3.0 2 1 1 3 3 3 2 Granulin 7tm_1 PF00001.21 CDW56183.1 - 1.7e-24 86.6 22.3 2.2e-24 86.2 22.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW56183.1 - 4e-06 26.6 15.2 4e-06 26.6 15.2 2.4 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx MRAP PF15183.6 CDW56183.1 - 0.75 9.8 5.5 13 5.8 0.5 2.8 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Cation_efflux PF01545.21 CDW56185.1 - 1.4e-23 83.7 4.2 1.7e-23 83.4 4.2 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDW56185.1 - 5.8e-12 45.6 0.8 1.2e-11 44.6 0.8 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF3654 PF12376.8 CDW56185.1 - 0.031 14.5 2.2 0.083 13.1 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3654) DUF1908 PF08926.11 CDW56189.1 - 5e-73 245.7 8.2 1.1e-72 244.6 8.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1908) Pkinase PF00069.25 CDW56189.1 - 3e-61 207.1 0.0 5e-61 206.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56189.1 - 1.4e-28 100.0 0.0 3.9e-28 98.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW56189.1 - 5.9e-08 32.4 0.3 9.4e-07 28.4 0.0 2.2 2 0 0 2 2 2 1 Kinase-like PDZ PF00595.24 CDW56189.1 - 1.3e-06 28.6 0.0 2.8e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain APH PF01636.23 CDW56189.1 - 5e-05 23.4 0.0 0.0078 16.2 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family PDZ_6 PF17820.1 CDW56189.1 - 8.5e-05 22.3 0.0 0.0003 20.6 0.0 2.0 2 0 0 2 2 2 1 PDZ domain Haspin_kinase PF12330.8 CDW56189.1 - 0.0023 16.9 0.1 0.0045 16.0 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Paramyxo_C PF01692.18 CDW56189.1 - 0.0038 16.6 0.2 0.0071 15.7 0.2 1.4 1 0 0 1 1 1 1 Paramyxovirus non-structural protein C PDZ_2 PF13180.6 CDW56189.1 - 0.0053 17.1 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Kdo PF06293.14 CDW56189.1 - 0.016 14.6 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDW56189.1 - 0.14 11.8 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family SelP_N PF04592.14 CDW56189.1 - 0.58 9.5 12.0 1.3 8.3 12.0 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Ion_trans PF00520.31 CDW56190.1 - 2.5e-20 72.8 13.8 9.9e-20 70.8 13.8 1.8 1 1 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 CDW56190.1 - 1.1e-19 70.3 0.0 1.8e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CLZ PF16526.5 CDW56190.1 - 3.6e-11 43.2 5.7 8.2e-11 42.1 5.7 1.6 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ion_trans_2 PF07885.16 CDW56190.1 - 0.0053 16.7 4.5 0.0053 16.7 4.5 3.1 3 1 0 3 3 3 1 Ion channel FliD_C PF07195.12 CDW56190.1 - 0.026 13.9 0.9 0.08 12.3 0.5 1.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Gp-FAR-1 PF05823.12 CDW56190.1 - 0.059 13.7 1.4 0.82 10.0 0.3 2.7 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Motile_Sperm PF00635.26 CDW56191.1 - 2.3e-18 66.0 0.0 3.5e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain GTP_EFTU PF00009.27 CDW56192.1 - 1.2e-55 188.1 0.6 1.7e-55 187.6 0.6 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDW56192.1 - 1.9e-10 41.0 0.0 4.6e-10 39.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDW56192.1 - 5.1e-07 30.0 6.6 8.1e-07 29.3 4.9 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW56192.1 - 0.00038 20.5 0.1 0.00073 19.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 CDW56192.1 - 0.0069 16.0 0.2 0.055 13.1 0.0 2.0 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain PUFD PF16553.5 CDW56192.1 - 0.13 12.4 0.1 5.6 7.1 0.1 2.2 2 0 0 2 2 2 0 BCORL-PCGF1-binding domain FeoB_N PF02421.18 CDW56192.1 - 0.21 11.1 1.5 3.9 7.0 1.6 2.5 1 1 0 1 1 1 0 Ferrous iron transport protein B Ldl_recept_b PF00058.17 CDW56193.1 - 5.7e-67 221.9 29.5 9.8e-11 42.0 0.1 16.1 16 0 0 16 16 16 13 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 CDW56193.1 - 4.7e-21 74.7 38.7 1.6e-08 34.6 8.4 4.3 2 1 1 3 3 3 3 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 CDW56193.1 - 5.2e-17 61.8 68.1 2.1e-11 43.9 7.3 5.1 5 0 0 5 5 5 4 Coagulation Factor Xa inhibitory site SGL PF08450.12 CDW56193.1 - 1.6e-11 44.3 6.5 0.15 11.6 0.0 8.1 7 1 0 8 8 8 3 SMP-30/Gluconolactonase/LRE-like region Biopterin_H PF00351.21 CDW56193.1 - 0.15 11.1 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 Biopterin-dependent aromatic amino acid hydroxylase SL4P PF17618.2 CDW56193.1 - 0.23 11.5 11.2 2.2 8.4 0.0 6.0 7 0 0 7 7 7 0 Uncharacterized Strongylid L4 protein EGF PF00008.27 CDW56194.1 - 1.3e-18 66.9 56.0 1.6e-06 28.2 5.5 4.6 4 0 0 4 4 4 4 EGF-like domain Reeler PF02014.16 CDW56194.1 - 2e-15 57.7 0.1 4.3e-15 56.6 0.1 1.6 1 0 0 1 1 1 1 Reeler domain hEGF PF12661.7 CDW56194.1 - 2.1e-10 40.8 48.9 0.0047 17.5 8.0 5.4 5 0 0 5 5 4 4 Human growth factor-like EGF EGF_2 PF07974.13 CDW56194.1 - 5.1e-09 36.3 71.6 1.4e-05 25.3 9.2 5.5 5 0 0 5 5 5 4 EGF-like domain DUF1794 PF08768.11 CDW56194.1 - 7.9e-09 35.6 0.0 2.4e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1794) ShK PF01549.24 CDW56194.1 - 5.7e-05 23.6 7.7 5.7e-05 23.6 7.7 3.9 4 2 0 4 4 1 1 ShK domain-like EGF_CA PF07645.15 CDW56194.1 - 0.00017 21.7 55.1 0.54 10.5 10.7 4.8 1 1 3 4 4 4 3 Calcium-binding EGF domain FXa_inhibition PF14670.6 CDW56194.1 - 0.015 15.6 46.9 0.44 10.9 8.7 4.7 1 1 3 4 4 4 0 Coagulation Factor Xa inhibitory site EGF_alliinase PF04863.13 CDW56194.1 - 0.027 14.9 3.4 0.027 14.9 3.4 4.1 3 1 2 5 5 3 0 Alliinase EGF-like domain EGF_3 PF12947.7 CDW56194.1 - 0.36 11.1 51.1 0.092 13.0 5.1 5.2 4 2 0 5 5 5 0 EGF domain cEGF PF12662.7 CDW56194.1 - 0.4 10.7 29.4 0.16 11.9 3.6 4.6 4 0 0 4 4 4 0 Complement Clr-like EGF-like Plasmod_Pvs28 PF06247.11 CDW56194.1 - 2.3 8.6 45.4 0.44 10.9 6.8 4.5 4 0 0 4 4 4 0 Pvs28 EGF domain Glyco_hydro_15 PF00723.21 CDW56195.1 - 1.3e-96 324.1 0.0 2.2e-96 323.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 DUF1256 PF06866.11 CDW56195.1 - 0.18 11.2 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1256) DUF1794 PF08768.11 CDW56196.1 - 4.2e-25 88.4 0.1 4.7e-25 88.3 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) SLD5_C PF16922.5 CDW56198.1 - 4.2e-06 26.9 0.2 1.8e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 DNA replication complex GINS protein SLD5 C-terminus Pkinase PF00069.25 CDW56199.1 - 4.4e-25 88.5 0.1 5.3e-25 88.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56199.1 - 1.8e-13 50.4 0.0 2.3e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW56199.1 - 1.2e-05 24.3 0.0 1.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW56199.1 - 0.0053 16.7 0.0 0.75 9.7 0.0 2.4 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 CDW56199.1 - 0.035 13.5 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CDW56199.1 - 0.037 13.6 0.1 4.2 6.9 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Ank_2 PF12796.7 CDW56200.1 - 2.7e-72 239.4 18.6 4.5e-14 52.8 0.4 11.1 5 2 7 12 12 12 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW56200.1 - 2.9e-52 174.4 24.9 2.4e-09 37.6 0.0 15.3 5 4 13 18 18 18 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW56200.1 - 2.5e-50 162.6 26.1 0.0055 17.1 0.0 19.7 20 0 0 20 20 19 10 Ankyrin repeat Ank_5 PF13857.6 CDW56200.1 - 4.8e-47 157.4 30.0 1.3e-07 31.7 0.4 16.4 5 2 14 19 19 19 13 Ankyrin repeats (many copies) Ank PF00023.30 CDW56200.1 - 8e-36 120.9 33.2 1.1e-05 25.6 0.0 17.1 19 1 0 19 19 19 9 Ankyrin repeat FYVE PF01363.21 CDW56200.1 - 2.6e-17 62.7 8.8 7.2e-17 61.3 8.8 1.8 1 0 0 1 1 1 1 FYVE zinc finger BTB PF00651.31 CDW56200.1 - 2.9e-09 37.1 0.0 1.2e-08 35.2 0.0 2.1 1 0 0 1 1 1 1 BTB/POZ domain FYVE_2 PF02318.16 CDW56200.1 - 0.042 14.1 5.8 0.13 12.5 5.8 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger zf-ribbon_3 PF13248.6 CDW56200.1 - 0.084 12.3 1.0 0.25 10.8 1.0 1.9 1 0 0 1 1 1 0 zinc-ribbon domain BACK PF07707.15 CDW56200.1 - 0.27 11.3 1.6 1.4 9.0 0.2 2.5 2 0 0 2 2 2 0 BTB And C-terminal Kelch DZR PF12773.7 CDW56200.1 - 2.2 8.4 7.4 29 4.8 7.6 2.5 1 1 0 1 1 1 0 Double zinc ribbon Neur_chan_memb PF02932.16 CDW56202.1 - 9.1e-75 251.8 0.1 1.2e-74 251.4 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 CDW56202.1 - 2e-66 223.6 7.2 1.4e-58 197.9 2.8 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Claudin_2 PF13903.6 CDW56202.1 - 0.085 12.6 3.7 0.089 12.5 2.1 1.8 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2417 PF10329.9 CDW56202.1 - 4.8 6.5 10.0 0.91 8.9 6.3 1.6 2 0 0 2 2 2 0 Region of unknown function (DUF2417) DUF3278 PF11683.8 CDW56202.1 - 5.7 7.0 6.3 0.68 10.0 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) Neur_chan_memb PF02932.16 CDW56203.1 - 2.4e-110 368.2 6.0 1.7e-63 214.9 0.7 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 CDW56203.1 - 1.4e-107 358.1 7.7 4.4e-61 206.1 0.8 3.1 2 1 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Asp4 PF16996.5 CDW56203.1 - 0.7 9.7 3.3 5.9 6.8 0.3 2.8 2 0 0 2 2 2 0 Accessory secretory protein Sec Asp4 DDOST_48kD PF03345.14 CDW56204.1 - 1.3e-140 468.9 0.0 1.6e-140 468.7 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Globin PF00042.22 CDW56205.1 - 0.002 18.6 0.0 0.0033 17.9 0.0 1.3 1 0 0 1 1 1 1 Globin NTP_transferase PF00483.23 CDW56206.1 - 1.1e-22 80.8 0.0 1.6e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 CDW56206.1 - 2.6e-13 49.1 6.1 3.3e-09 36.1 0.2 3.8 3 1 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CDW56206.1 - 7.9e-05 23.1 0.0 0.00018 21.9 0.0 1.6 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 CDW56206.1 - 0.0047 16.7 2.7 0.023 14.4 0.6 2.8 2 1 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 CDW56206.1 - 0.0051 15.8 0.0 0.015 14.3 0.0 1.8 2 0 0 2 2 2 1 L-fucokinase Cpn60_TCP1 PF00118.24 CDW56208.1 - 5.8e-23 81.3 0.0 7.4e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF229 PF02995.17 CDW56209.1 - 1.4e-98 330.7 8.4 3.1e-97 326.3 8.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF229) LANC_like PF05147.13 CDW56210.1 - 2.4e-61 207.3 0.0 2.8e-61 207.0 0.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Glyco_hydro_127 PF07944.12 CDW56210.1 - 0.056 11.9 0.0 0.089 11.3 0.0 1.2 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 Band_7 PF01145.25 CDW56211.1 - 7.3e-07 29.4 0.1 9.3e-07 29.0 0.1 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family ELL PF10390.9 CDW56212.1 - 6.2e-36 124.3 1.6 2.4e-35 122.4 1.6 2.0 1 1 0 1 1 1 1 RNA polymerase II elongation factor ELL Occludin_ELL PF07303.13 CDW56212.1 - 8.6e-23 81.0 1.0 8.6e-23 81.0 1.0 2.2 2 0 0 2 2 2 1 Occludin homology domain DUF4398 PF14346.6 CDW56212.1 - 0.021 15.5 0.4 0.072 13.7 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4398) RNase_PH PF01138.21 CDW56213.1 - 1.1e-13 51.8 0.2 2.3e-13 50.8 0.2 1.5 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDW56213.1 - 2.3e-07 30.8 0.0 8.6e-07 28.9 0.0 2.0 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Kinesin PF00225.23 CDW56214.1 - 5.8e-85 285.1 0.1 5.3e-71 239.2 0.0 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 CDW56214.1 - 9.7e-20 71.0 0.0 2.6e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding Yop-YscD_cpl PF16697.5 CDW56214.1 - 1.9e-07 31.3 0.0 6.1e-07 29.7 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 CDW56214.1 - 2.1e-05 24.7 1.5 0.00013 22.2 0.1 2.9 2 1 0 2 2 2 1 FHA domain DUF22 PF01629.16 CDW56214.1 - 0.057 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function DUF22 FapA PF03961.13 CDW56214.1 - 0.061 11.9 1.9 0.1 11.2 1.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A SlyX PF04102.12 CDW56214.1 - 1.6 9.4 3.3 4.8 7.9 0.9 2.6 2 0 0 2 2 2 0 SlyX EF_TS PF00889.19 CDW56215.1 - 5.4e-26 91.5 0.0 8.8e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor TS DNA_gyraseA_C PF03989.13 CDW56215.1 - 0.022 14.3 0.0 0.057 12.9 0.0 1.7 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller Reticulon PF02453.17 CDW56216.1 - 2.8e-20 72.9 1.5 3.9e-20 72.4 1.5 1.2 1 0 0 1 1 1 1 Reticulon G0-G1_switch_2 PF15103.6 CDW56216.1 - 0.0086 16.5 0.1 0.027 14.9 0.1 1.8 1 0 0 1 1 1 1 G0/G1 switch protein 2 DUF1794 PF08768.11 CDW56217.1 - 4.4e-07 30.0 0.0 5.7e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) PTH2 PF01981.16 CDW56218.1 - 2.5e-31 108.4 0.0 3.7e-31 107.9 0.0 1.3 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 WAP PF00095.21 CDW56219.1 - 8.7e-13 48.4 41.4 4.4e-08 33.4 6.6 13.8 12 3 2 14 14 14 6 WAP-type (Whey Acidic Protein) 'four-disulfide core' TIL PF01826.17 CDW56219.1 - 4.5e-08 33.2 14.9 4.5e-08 33.2 14.9 11.0 5 2 4 9 9 9 2 Trypsin Inhibitor like cysteine rich domain COX16 PF14138.6 CDW56219.1 - 0.0035 17.8 0.0 0.0064 17.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 EGF PF00008.27 CDW56220.1 - 0.0097 16.2 1.1 0.0097 16.2 1.1 3.6 4 1 0 4 4 4 1 EGF-like domain EGF_CA PF07645.15 CDW56220.1 - 0.03 14.5 1.9 0.03 14.5 1.9 3.0 1 1 1 2 2 2 0 Calcium-binding EGF domain Laminin_EGF PF00053.24 CDW56220.1 - 0.82 9.9 18.6 0.061 13.5 7.2 3.1 2 1 0 2 2 2 0 Laminin EGF domain Collagen PF01391.18 CDW56221.1 - 1.5e-63 210.4 235.3 3.2e-10 39.6 29.7 10.6 7 3 3 10 10 10 10 Collagen triple helix repeat (20 copies) Arf PF00025.21 CDW56222.1 - 3e-61 205.9 0.0 3.4e-61 205.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CDW56222.1 - 2.9e-10 39.8 0.0 1.1e-07 31.4 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CDW56222.1 - 1e-07 31.6 0.0 1.2e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CDW56222.1 - 1.5e-07 31.7 0.0 3.5e-07 30.4 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CDW56222.1 - 2.5e-07 30.8 0.0 3.4e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 CDW56222.1 - 3e-06 26.9 0.0 3.3e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CDW56222.1 - 5.6e-05 22.6 0.0 6.2e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region cobW PF02492.19 CDW56222.1 - 0.001 18.7 0.0 0.053 13.1 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Ish1 PF10281.9 CDW56222.1 - 0.097 13.0 0.3 0.21 11.9 0.0 1.7 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein PurA PF04845.13 CDW56223.1 - 2.2e-79 265.9 3.3 2.5e-79 265.6 3.3 1.0 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein DUF3276 PF11680.8 CDW56223.1 - 0.00098 19.3 12.3 0.29 11.3 1.8 4.3 2 2 2 4 4 4 3 Protein of unknown function (DUF3276) DUF3467 PF11950.8 CDW56223.1 - 0.11 12.6 0.0 3.4 7.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3467) Wzy_C PF04932.15 CDW56224.1 - 0.069 12.8 1.4 0.76 9.4 1.0 2.2 2 0 0 2 2 2 0 O-Antigen ligase Claudin_3 PF06653.11 CDW56224.1 - 0.2 11.6 9.2 0.27 11.1 9.2 1.2 1 0 0 1 1 1 0 Tight junction protein, Claudin-like DUF4233 PF14017.6 CDW56224.1 - 0.63 10.4 11.9 0.57 10.5 0.3 2.8 3 1 1 4 4 3 0 Protein of unknown function (DUF4233) GT87 PF09594.10 CDW56224.1 - 1.7 8.3 11.1 0.19 11.4 6.7 1.5 2 0 0 2 2 2 0 Glycosyltransferase family 87 Ribosomal_L32e PF01655.18 CDW56225.1 - 6.3e-29 100.6 5.9 7.6e-29 100.3 3.2 2.4 3 0 0 3 3 3 1 Ribosomal protein L32 JmjC PF02373.22 CDW56225.1 - 1.5e-23 83.4 0.0 3.3e-23 82.3 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 CDW56225.1 - 9.9e-19 68.0 0.0 2.5e-18 66.7 0.0 1.7 1 1 0 1 1 1 1 Cupin-like domain SR-25 PF10500.9 CDW56225.1 - 0.24 11.0 14.5 0.49 10.0 14.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SNF2_N PF00176.23 CDW56227.1 - 1.4e-68 231.2 2.3 2.4e-68 230.4 2.3 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW56227.1 - 3.2e-20 72.5 0.2 1e-19 70.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 CDW56227.1 - 2.2e-12 47.1 1.2 9.7e-12 45.0 1.2 2.2 1 0 0 1 1 1 1 HSA ResIII PF04851.15 CDW56227.1 - 6.2e-07 29.6 0.0 1.4e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit EspB PF05802.11 CDW56227.1 - 3.3 7.6 5.7 0.68 9.9 1.9 1.7 2 0 0 2 2 2 0 Enterobacterial EspB protein GatB_N PF02934.15 CDW56228.1 - 2.1e-67 227.4 0.1 2.4e-54 184.6 0.1 2.0 1 1 1 2 2 2 2 GatB/GatE catalytic domain DUF1107 PF06526.12 CDW56228.1 - 0.0072 16.2 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1107) IP_trans PF02121.18 CDW56229.1 - 4.9e-111 370.2 0.2 5.5e-111 370.0 0.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein XLF PF09302.11 CDW56230.1 - 7.9e-14 52.2 0.0 1.3e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component His_Phos_1 PF00300.22 CDW56231.1 - 1.2e-09 38.1 0.0 2.8e-09 37.0 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TPR_12 PF13424.6 CDW56232.1 - 2.9e-42 142.8 55.6 5.4e-07 29.8 0.3 15.7 10 4 8 18 18 18 13 Tetratricopeptide repeat TPR_2 PF07719.17 CDW56232.1 - 8.8e-33 109.8 52.8 0.001 19.0 0.3 21.3 24 1 0 24 24 23 9 Tetratricopeptide repeat TPR_1 PF00515.28 CDW56232.1 - 1.6e-26 91.0 37.4 0.00025 20.7 0.4 16.8 18 0 0 18 18 17 6 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW56232.1 - 1.8e-21 76.9 45.4 1.2e-11 44.6 2.1 7.6 3 2 4 8 8 8 6 MalT-like TPR region TPR_7 PF13176.6 CDW56232.1 - 2.8e-19 67.7 31.4 0.31 11.2 0.1 15.3 18 0 0 18 18 17 5 Tetratricopeptide repeat TPR_8 PF13181.6 CDW56232.1 - 9.6e-18 62.9 30.9 0.064 13.5 0.0 17.4 18 0 0 18 18 17 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW56232.1 - 3.3e-14 52.4 35.8 5.6 8.1 0.0 17.6 14 6 5 20 20 18 2 Tetratricopeptide repeat TPR_19 PF14559.6 CDW56232.1 - 5.5e-11 42.8 28.4 0.0022 18.5 0.0 11.9 9 3 3 12 12 12 3 Tetratricopeptide repeat DUF4807 PF16065.5 CDW56232.1 - 4.7e-10 39.2 8.2 0.0012 18.5 0.3 4.6 4 0 0 4 4 4 3 Domain of unknown function (DUF4807) TPR_16 PF13432.6 CDW56232.1 - 1.8e-09 38.1 30.5 0.11 13.2 0.0 10.5 10 1 1 11 11 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 CDW56232.1 - 3.4e-08 33.0 13.6 0.0057 16.3 0.0 8.6 7 1 2 9 9 8 2 TPR repeat Fis1_TPR_C PF14853.6 CDW56232.1 - 1.5e-07 31.4 5.0 0.52 10.4 0.1 7.0 8 0 0 8 8 6 2 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 CDW56232.1 - 1.5e-07 31.3 11.3 0.091 13.2 0.0 7.6 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDW56232.1 - 6.6e-07 29.0 33.0 0.84 9.6 0.2 14.3 18 0 0 18 18 14 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW56232.1 - 3.1e-06 27.5 24.5 0.96 10.2 0.1 12.2 13 0 0 13 13 10 1 Tetratricopeptide repeat TPR_4 PF07721.14 CDW56232.1 - 8.5e-06 25.9 4.1 9 7.3 0.0 7.5 9 0 0 9 9 6 0 Tetratricopeptide repeat Rapsyn_N PF10579.9 CDW56232.1 - 1.2e-05 25.3 3.1 1.2 9.3 0.0 5.6 5 1 0 5 5 5 2 Rapsyn N-terminal myristoylation and linker region ANAPC5 PF12862.7 CDW56232.1 - 0.0029 17.7 16.9 0.032 14.3 0.0 6.6 7 1 0 7 7 7 1 Anaphase-promoting complex subunit 5 TPR_9 PF13371.6 CDW56232.1 - 0.0079 16.3 9.2 0.83 9.8 0.0 6.6 6 2 1 7 7 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 CDW56232.1 - 0.042 13.9 8.3 0.3 11.2 0.5 5.3 4 1 0 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_3 PF07720.12 CDW56232.1 - 0.87 9.6 10.0 1.4 9.0 0.1 5.3 5 0 0 5 5 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 CDW56232.1 - 1.9 8.0 4.4 11 5.6 0.0 4.4 5 0 0 5 5 5 0 SHNi-TPR PGM_PMM_I PF02878.16 CDW56233.1 - 6.2e-71 236.5 0.0 1.1e-38 132.1 0.0 2.4 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CDW56233.1 - 2e-38 131.1 0.0 8.7e-20 71.3 0.0 2.7 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CDW56233.1 - 5.7e-16 58.7 0.1 1.2e-06 28.7 0.0 2.5 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 CDW56233.1 - 2.9e-11 43.4 0.0 1.4e-05 25.2 0.0 2.6 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, C-terminal domain Ribonuc_L-PSP PF01042.21 CDW56234.1 - 3.1e-40 136.9 0.0 3.5e-40 136.8 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Motile_Sperm PF00635.26 CDW56235.1 - 3.1e-14 52.7 0.0 4.1e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Es2 PF09751.9 CDW56236.1 - 9.1e-78 262.9 12.0 5.7e-76 257.0 12.0 2.3 1 1 0 1 1 1 1 Nuclear protein Es2 UQ_con PF00179.26 CDW56237.1 - 2.6e-49 166.5 0.0 3.1e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LIN37 PF15306.6 CDW56238.1 - 6.2e-11 42.8 2.0 1.4e-09 38.4 2.0 2.1 1 1 0 1 1 1 1 LIN37 Laminin_G_2 PF02210.24 CDW56239.1 - 2e-67 225.5 2.8 5.2e-28 98.2 0.0 6.4 6 1 0 6 6 6 5 Laminin G domain Laminin_G_1 PF00054.23 CDW56239.1 - 7.7e-48 162.0 0.0 1.7e-22 80.0 0.0 5.5 5 0 0 5 5 5 5 Laminin G domain EGF PF00008.27 CDW56239.1 - 0.0003 21.0 5.2 0.0003 21.0 5.2 2.7 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 CDW56239.1 - 0.0058 17.2 2.8 0.0058 17.2 2.8 2.8 2 0 0 2 2 2 1 Human growth factor-like EGF Laminin_G_3 PF13385.6 CDW56239.1 - 0.0067 16.6 2.1 0.69 10.1 0.1 3.5 3 1 0 3 3 3 1 Concanavalin A-like lectin/glucanases superfamily Syndecan PF01034.20 CDW56240.1 - 0.008 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Syndecan domain Adeno_E3_CR2 PF02439.15 CDW56240.1 - 0.062 13.1 1.8 0.1 12.4 1.8 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 zf-rbx1 PF12678.7 CDW56241.1 - 4.7e-24 84.4 13.4 6.7e-24 83.9 13.4 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDW56241.1 - 9.3e-17 60.9 11.2 1.3e-16 60.4 11.2 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CDW56241.1 - 1.7e-05 25.0 16.1 0.00036 20.8 16.1 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW56241.1 - 0.007 16.2 9.7 0.007 16.2 9.7 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW56241.1 - 0.014 15.3 12.9 0.17 11.8 12.9 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDW56241.1 - 0.3 11.3 7.8 1.8 8.8 8.2 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-RING_11 PF17123.5 CDW56241.1 - 0.43 10.4 14.4 10 5.9 14.4 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 CDW56241.1 - 0.65 9.9 11.0 2.2 8.2 5.4 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDW56241.1 - 0.69 9.6 17.7 0.14 11.8 6.7 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CDW56241.1 - 1.4 9.0 9.0 4.4 7.4 9.0 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDW56241.1 - 9.5 6.5 10.3 0.5 10.6 0.9 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING TPR_1 PF00515.28 CDW56242.1 - 7e-63 206.1 25.4 8.8e-08 31.7 0.0 9.3 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 CDW56242.1 - 9.5e-49 159.6 23.3 3.3e-06 26.8 0.3 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 CDW56242.1 - 6.6e-32 108.9 22.6 1.1e-07 31.5 0.0 7.8 5 2 3 8 8 8 5 TPR repeat TPR_8 PF13181.6 CDW56242.1 - 2e-28 96.2 27.5 0.00077 19.5 0.1 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_19 PF14559.6 CDW56242.1 - 1.6e-24 86.2 8.1 0.00018 21.9 0.4 6.4 5 1 0 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 CDW56242.1 - 5.3e-24 82.9 3.7 0.0068 17.1 0.1 8.5 5 3 4 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 CDW56242.1 - 3.8e-23 81.6 20.0 3.9e-09 36.7 0.1 7.6 3 3 4 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 CDW56242.1 - 7e-21 73.0 17.0 7.9e-06 25.9 0.3 8.3 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 CDW56242.1 - 1.8e-15 57.3 12.3 0.00055 20.5 0.2 5.9 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDW56242.1 - 3e-15 55.0 15.0 0.0031 17.4 0.0 8.7 9 0 0 9 9 9 3 Tetratricopeptide repeat STI1 PF17830.1 CDW56242.1 - 3.4e-15 55.7 2.8 5.8e-15 55.0 1.0 2.4 2 0 0 2 2 2 1 STI1 domain TPR_10 PF13374.6 CDW56242.1 - 1.5e-10 40.6 15.1 0.2 11.6 0.0 8.6 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW56242.1 - 2.9e-08 33.8 0.0 0.03 14.4 0.0 4.3 4 1 1 5 5 4 3 Tetratricopeptide repeat NARP1 PF12569.8 CDW56242.1 - 4.5e-08 32.5 12.0 4.9e-06 25.7 6.6 2.6 2 1 1 3 3 3 3 NMDA receptor-regulated protein 1 ANAPC3 PF12895.7 CDW56242.1 - 2.7e-07 30.7 14.8 0.5 10.6 0.3 5.5 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CDW56242.1 - 1.1e-06 28.9 17.1 1.1 10.0 0.1 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW56242.1 - 5.8e-06 26.3 16.9 2.3 8.3 0.0 7.8 7 1 1 8 8 8 1 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.9 CDW56242.1 - 1.1e-05 25.2 15.3 0.003 17.3 2.0 5.5 2 2 0 3 3 3 2 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 CDW56242.1 - 0.0002 21.6 5.7 0.019 15.3 0.0 4.8 3 2 2 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 CDW56242.1 - 0.00054 20.0 22.3 0.048 13.7 0.4 6.3 7 0 0 7 7 7 3 MIT (microtubule interacting and transport) domain TOM20_plant PF06552.12 CDW56242.1 - 0.013 15.2 6.7 10 5.8 0.0 4.4 3 1 0 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_15 PF13429.6 CDW56242.1 - 0.022 14.0 7.3 4.2 6.5 0.0 4.7 2 2 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 CDW56242.1 - 0.024 14.9 11.4 11 6.5 0.1 6.0 7 0 0 7 7 4 0 PPR repeat ChAPs PF09295.10 CDW56242.1 - 0.028 13.4 1.2 1.2 8.1 0.0 2.9 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) SHNi-TPR PF10516.9 CDW56242.1 - 0.047 13.1 4.7 21 4.7 0.0 5.0 5 0 0 5 5 5 0 SHNi-TPR BTAD PF03704.17 CDW56242.1 - 0.14 12.6 10.0 1.9 8.9 0.1 4.5 4 1 1 5 5 4 0 Bacterial transcriptional activator domain DUF3856 PF12968.7 CDW56242.1 - 0.15 12.1 14.3 15 5.7 1.9 5.8 2 2 2 4 4 4 0 Domain of Unknown Function (DUF3856) PPR_2 PF13041.6 CDW56242.1 - 0.19 11.9 3.0 51 4.2 0.0 4.5 5 0 0 5 5 4 0 PPR repeat family Glyoxalase_2 PF12681.7 CDW56242.1 - 0.21 11.5 0.7 0.6 10.1 0.1 2.1 2 0 0 2 2 1 0 Glyoxalase-like domain Alkyl_sulf_dimr PF14863.6 CDW56242.1 - 0.47 10.9 8.6 3.5 8.1 0.2 4.1 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation NRBF2_MIT PF17169.4 CDW56242.1 - 2.4 8.5 10.6 1.7 8.9 0.1 4.4 4 2 2 6 6 5 0 MIT domain of nuclear receptor-binding factor 2 Mcl1_mid PF12341.8 CDW56244.1 - 1.6e-71 241.1 1.7 2.3e-69 234.0 0.4 2.4 2 0 0 2 2 2 2 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 CDW56244.1 - 4.1e-14 52.8 1.1 0.0038 18.0 0.1 5.3 4 0 0 4 4 4 4 WD domain, G-beta repeat Cytochrome_cB PF11783.8 CDW56244.1 - 0.051 13.5 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Cytochrome c bacterial WD40 PF00400.32 CDW56245.1 - 3.3e-06 27.7 12.4 0.46 11.5 0.1 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat Dynein_IC2 PF11540.8 CDW56245.1 - 0.00044 20.1 3.2 0.00096 19.1 3.2 1.6 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 ANAPC4_WD40 PF12894.7 CDW56245.1 - 0.014 15.6 0.0 0.6 10.4 0.0 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Phage_Nu1 PF07471.12 CDW56245.1 - 0.069 12.9 5.4 1.1 9.0 0.0 2.6 3 0 0 3 3 3 0 Phage DNA packaging protein Nu1 PQQ PF01011.21 CDW56245.1 - 0.1 12.6 0.2 8.6 6.5 0.0 2.8 2 0 0 2 2 2 0 PQQ enzyme repeat PQQ_3 PF13570.6 CDW56245.1 - 0.13 12.8 0.4 13 6.5 0.0 3.2 3 0 0 3 3 3 0 PQQ-like domain Ribosomal_L12 PF00542.19 CDW56246.1 - 4.7e-17 62.1 2.6 4.7e-17 62.1 2.6 1.9 3 0 0 3 3 3 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CDW56246.1 - 8.3e-08 31.8 0.2 5.1e-07 29.3 0.0 2.2 2 1 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain CENP-U PF13097.6 CDW56247.1 - 0.041 13.8 0.2 0.082 12.9 0.2 1.5 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit Mpp10 PF04006.12 CDW56247.1 - 0.075 11.5 0.2 0.093 11.2 0.2 1.1 1 0 0 1 1 1 0 Mpp10 protein RGS_DHEX PF18148.1 CDW56249.1 - 1.1e-46 157.0 1.6 1.1e-46 157.0 1.6 2.3 2 0 0 2 2 2 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 CDW56249.1 - 3.3e-30 104.8 0.2 9.2e-30 103.3 0.2 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 CDW56249.1 - 5.2e-13 48.9 0.0 1.5e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 CDW56249.1 - 9.1e-13 48.0 0.1 2.7e-12 46.5 0.1 1.9 2 0 0 2 2 2 1 GGL domain DUF72 PF01904.18 CDW56249.1 - 0.024 14.7 0.2 0.049 13.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF72 CDI PF02234.19 CDW56249.1 - 0.25 11.5 3.1 0.27 11.4 1.3 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor Peptidase_C97 PF05903.14 CDW56250.1 - 1.6e-38 131.9 0.1 2e-38 131.6 0.1 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 CDW56250.1 - 0.11 12.8 0.1 0.17 12.2 0.1 1.2 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Rhabdo_ncap_2 PF03216.13 CDW56252.1 - 8.9e-90 301.2 2.4 1.1e-89 301.0 2.4 1.0 1 0 0 1 1 1 1 Rhabdovirus nucleoprotein WH1 PF00568.23 CDW56253.1 - 1.9e-25 89.0 0.5 3.2e-25 88.2 0.5 1.4 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.11 CDW56253.1 - 0.0009 18.8 1.0 0.0017 17.9 1.0 1.3 1 0 0 1 1 1 1 VASP tetramerisation domain Ran_BP1 PF00638.18 CDW56253.1 - 0.14 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 RanBP1 domain TFIIA PF03153.13 CDW56255.1 - 1.4e-58 199.9 0.1 1.1e-38 134.4 0.5 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Fe-S_biosyn PF01521.20 CDW56255.1 - 5.5e-20 71.6 0.0 1.1e-19 70.7 0.0 1.5 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF2722 PF10846.8 CDW56255.1 - 0.18 10.7 0.2 0.26 10.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pro_isomerase PF00160.21 CDW56256.1 - 9.4e-51 172.2 0.7 1.1e-50 172.0 0.7 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-UBR PF02207.20 CDW56257.1 - 5.6e-20 71.3 12.2 5.6e-20 71.3 12.2 2.4 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 CDW56257.1 - 2.4e-14 52.9 0.0 5e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS STI1 PF17830.1 CDW56258.1 - 0.042 13.8 1.2 0.095 12.6 0.6 2.0 2 0 0 2 2 2 0 STI1 domain LRR_4 PF12799.7 CDW56258.1 - 3 8.4 6.3 1.4 9.5 2.8 2.1 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Secretogranin_V PF05281.11 CDW56259.1 - 9.9e-51 172.5 0.2 1.5e-50 171.9 0.2 1.2 1 0 0 1 1 1 1 Neuroendocrine protein 7B2 precursor (Secretogranin V) PseudoU_synth_2 PF00849.22 CDW56260.1 - 2.8e-24 86.0 0.0 5.9e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDW56260.1 - 0.0091 15.7 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 S4 domain WAP PF00095.21 CDW56261.1 - 1.3e-19 70.3 35.0 4.1e-09 36.7 7.2 3.2 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' Somatomedin_B PF01033.17 CDW56261.1 - 1.1 9.8 23.2 2.2 8.8 2.7 3.5 3 0 0 3 3 3 0 Somatomedin B domain Utp12 PF04003.12 CDW56262.1 - 7e-06 26.3 0.0 9.8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Dip2/Utp12 Family MT-A70 PF05063.14 CDW56263.1 - 3.2e-16 59.7 0.0 5.1e-11 42.8 0.0 2.1 2 0 0 2 2 2 2 MT-A70 Pox_RNA_pol_35 PF03396.15 CDW56263.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase, 35 kD subunit Thioredoxin PF00085.20 CDW56264.1 - 2.7e-13 49.8 0.0 4.8e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin SRR1 PF07985.12 CDW56264.1 - 0.066 13.3 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 SRR1 TraF PF13728.6 CDW56264.1 - 0.18 11.6 0.0 0.49 10.2 0.0 1.8 1 1 0 1 1 1 0 F plasmid transfer operon protein Molybdop_Fe4S4 PF04879.16 CDW56265.1 - 0.025 14.5 0.1 0.078 13.0 0.1 1.8 1 0 0 1 1 1 0 Molybdopterin oxidoreductase Fe4S4 domain TPR_12 PF13424.6 CDW56267.1 - 0.047 14.0 0.3 0.44 10.9 0.3 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat Ras PF00071.22 CDW56268.1 - 1.3e-45 154.9 0.0 1.7e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW56268.1 - 1.6e-31 109.0 0.0 2.7e-31 108.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW56268.1 - 2.1e-15 56.6 0.0 2.6e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW56268.1 - 1.1e-07 31.9 0.0 2.6e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW56268.1 - 5e-07 29.3 0.0 6.6e-07 28.9 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDW56268.1 - 0.0001 21.8 0.0 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CDW56268.1 - 0.00016 20.9 0.2 0.0038 16.4 0.2 2.4 1 1 1 2 2 2 1 G-protein alpha subunit TniB PF05621.11 CDW56268.1 - 0.00031 20.2 0.0 0.015 14.8 0.0 2.4 2 1 0 2 2 2 1 Bacterial TniB protein GTP_EFTU PF00009.27 CDW56268.1 - 0.00071 19.2 0.1 0.01 15.4 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain CENP-M PF11111.8 CDW56268.1 - 0.0045 16.2 0.0 0.0061 15.8 0.0 1.2 1 0 0 1 1 1 1 Centromere protein M (CENP-M) RsgA_GTPase PF03193.16 CDW56268.1 - 0.057 13.3 0.0 0.14 12.1 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 CDW56268.1 - 0.089 12.3 0.1 0.71 9.4 0.1 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B NOG1 PF06858.14 CDW56268.1 - 0.12 12.2 0.1 1.8 8.4 0.1 2.3 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) TUDOR PF00567.24 CDW56269.1 - 0.00016 21.7 0.0 0.055 13.5 0.0 2.3 2 0 0 2 2 2 2 Tudor domain UPF0121 PF03661.13 CDW56270.1 - 1.9e-70 237.0 11.0 2.3e-70 236.7 11.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF5366 PF17328.2 CDW56270.1 - 0.057 13.5 3.8 0.22 11.6 0.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5366) Bestrophin PF01062.21 CDW56272.1 - 2.5e-89 299.6 4.0 3.3e-89 299.2 4.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel V-ATPase_G PF03179.15 CDW56273.1 - 4.5e-35 120.3 19.5 5.1e-35 120.2 19.5 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 CDW56273.1 - 0.0075 16.7 17.2 0.011 16.1 17.2 1.3 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit vATP-synt_E PF01991.18 CDW56273.1 - 0.04 13.3 14.6 0.051 13.0 14.6 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Con-6 PF10346.9 CDW56273.1 - 0.072 13.1 3.2 0.22 11.6 3.2 1.9 1 0 0 1 1 1 0 Conidiation protein 6 CobU PF02283.16 CDW56273.1 - 0.32 10.5 4.6 0.39 10.3 4.4 1.4 1 1 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase HrpE PF06188.12 CDW56273.1 - 0.47 10.3 13.0 0.59 10.0 13.0 1.1 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E Exonuc_VII_L PF02601.15 CDW56273.1 - 2.6 7.5 10.6 2.8 7.4 10.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 CDW56273.1 - 3.6 6.4 4.9 3.9 6.3 4.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 CDW56273.1 - 4.9 7.5 20.7 6.1 7.2 20.7 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF883 PF05957.13 CDW56273.1 - 5.5 7.7 13.2 2.5 8.7 10.0 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ATP-synt_B PF00430.18 CDW56273.1 - 9 6.4 25.3 1.5e+02 2.5 25.5 2.0 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Pkinase_Tyr PF07714.17 CDW56274.1 - 8.2e-77 258.0 0.1 1e-76 257.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW56274.1 - 1.3e-42 146.0 0.0 1.7e-42 145.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW56274.1 - 3.6e-09 36.6 0.0 6.8e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain RIO1 PF01163.22 CDW56274.1 - 0.035 13.7 0.3 0.067 12.8 0.2 1.4 1 1 0 1 1 1 0 RIO1 family AA_permease PF00324.21 CDW56275.1 - 3.5e-110 368.8 32.6 4.2e-110 368.6 32.6 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 CDW56275.1 - 1.2e-107 360.6 0.4 1.1e-66 225.6 0.2 2.1 1 1 1 2 2 2 2 Solute carrier family 12 AA_permease_N PF08403.10 CDW56275.1 - 2.9e-06 26.7 0.0 4.3e-05 22.9 0.0 2.5 2 0 0 2 2 2 1 Amino acid permease N-terminal DUF2207 PF09972.9 CDW56275.1 - 4.5 5.9 15.0 6.7 5.3 0.4 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) ETRAMP PF09716.10 CDW56275.1 - 5.7 7.1 5.8 2.4 8.3 0.6 3.0 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) DNA_topoisoIV PF00521.20 CDW56276.1 - 7.4e-128 427.1 0.0 1.3e-127 426.3 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CDW56276.1 - 1.8e-47 160.8 5.7 1.8e-47 160.8 5.7 2.4 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CDW56276.1 - 2.1e-22 79.4 0.2 4.7e-22 78.3 0.2 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 CDW56276.1 - 1.3e-14 54.7 0.0 3.1e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDW56276.1 - 4.4e-08 33.3 0.0 1.4e-07 31.7 0.0 1.9 1 0 0 1 1 1 1 Toprim domain UPF0172 PF03665.13 CDW56276.1 - 0.57 10.2 5.3 0.084 12.9 0.8 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) SIKE PF05769.11 CDW56277.1 - 6.3e-06 26.2 10.8 1.2e-05 25.4 10.8 1.4 1 1 0 1 1 1 1 SIKE family DUF1319 PF07028.11 CDW56277.1 - 0.23 11.7 2.6 2.4 8.4 0.2 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1319) Sugar_tr PF00083.24 CDW56278.1 - 1.7e-68 231.5 18.8 6.1e-66 223.1 14.2 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CDW56278.1 - 7.8e-30 104.0 16.1 7.8e-30 104.0 16.1 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CDW56278.1 - 2.6e-09 36.0 5.1 2.6e-09 36.0 5.1 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 CDW56278.1 - 0.69 8.7 22.1 0.014 14.2 9.1 2.8 3 1 0 3 3 3 0 MFS_1 like family DUF2530 PF10745.9 CDW56278.1 - 3 8.1 7.3 1.5 9.1 0.9 3.2 2 2 0 2 2 2 0 Protein of unknown function (DUF2530) Sugar_tr PF00083.24 CDW56279.1 - 4.3e-135 451.1 70.0 9.1e-57 192.9 15.2 4.3 4 0 0 4 4 4 4 Sugar (and other) transporter MFS_1 PF07690.16 CDW56279.1 - 8.1e-39 133.5 87.6 5.5e-22 78.2 27.7 4.8 3 2 1 4 4 4 3 Major Facilitator Superfamily TRI12 PF06609.13 CDW56279.1 - 6.3e-07 28.2 10.1 1.1e-05 24.1 0.9 2.3 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) GHMP_kinases_N PF00288.26 CDW56280.1 - 8.3e-13 48.4 0.4 1.9e-12 47.2 0.4 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CDW56280.1 - 1e-06 29.0 0.0 3e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal SBDS_C PF09377.10 CDW56281.1 - 2.7e-33 114.4 0.1 5.6e-33 113.4 0.0 1.5 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 CDW56281.1 - 3e-33 113.8 0.6 5.6e-33 112.9 0.6 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein RhoGAP PF00620.27 CDW56282.1 - 2.7e-37 127.9 1.0 5e-37 127.1 0.4 1.7 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 CDW56282.1 - 1.7e-06 28.5 0.8 1.5e-05 25.4 0.1 2.4 2 0 0 2 2 2 1 PH domain SieB PF14163.6 CDW56282.1 - 0.054 13.0 0.9 0.11 12.0 0.9 1.5 1 0 0 1 1 1 0 Super-infection exclusion protein B Guanylate_cyc PF00211.20 CDW56284.1 - 6.6e-16 58.5 0.1 9.9e-16 57.9 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 CDW56284.1 - 8.4e-05 21.9 8.7 0.00012 21.4 8.7 1.1 1 0 0 1 1 1 1 Adenylyl cyclase N-terminal extracellular and transmembrane region UCH PF00443.29 CDW56285.1 - 5.3e-25 88.4 0.1 5.8e-25 88.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW56285.1 - 1e-13 51.6 0.4 1.2e-13 51.3 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CDW56285.1 - 0.0022 17.5 3.4 0.022 14.3 0.8 2.1 2 0 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase SPC22 PF04573.12 CDW56286.1 - 6e-51 172.3 0.0 6.8e-51 172.1 0.0 1.0 1 0 0 1 1 1 1 Signal peptidase subunit GARP PF16731.5 CDW56287.1 - 0.028 14.1 1.4 0.033 13.9 1.4 1.1 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma YqzH PF14164.6 CDW56287.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 YqzH-like protein CENP-T_C PF15511.6 CDW56288.1 - 4.2e-08 33.3 0.0 6.4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW56288.1 - 4.1e-05 23.9 0.0 7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW56288.1 - 0.00011 22.4 0.1 0.00019 21.7 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW56288.1 - 0.00016 21.8 0.1 0.00024 21.2 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 CDW56288.1 - 0.00027 21.3 0.1 0.00033 21.0 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 CDW56288.1 - 0.0004 20.3 0.0 0.00067 19.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 CDW56288.1 - 0.013 15.6 0.0 0.016 15.3 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 CDW56288.1 - 0.14 12.7 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Innexin PF00876.18 CDW56289.1 - 1.2e-117 393.1 15.9 1.4e-117 392.9 15.9 1.0 1 0 0 1 1 1 1 Innexin TraF PF13728.6 CDW56291.1 - 0.039 13.8 0.1 0.054 13.3 0.1 1.4 1 1 0 1 1 1 0 F plasmid transfer operon protein PP-binding PF00550.25 CDW56292.1 - 5.5e-12 45.9 0.1 6.2e-12 45.7 0.1 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ndr PF03096.14 CDW56293.1 - 2.9e-92 308.4 0.1 3.4e-92 308.1 0.1 1.0 1 0 0 1 1 1 1 Ndr family Rota_NSP4 PF01452.16 CDW56294.1 - 0.13 11.9 0.2 15 5.2 0.1 2.9 3 0 0 3 3 3 0 Rotavirus non structural protein Topoisom_bac PF01131.20 CDW56295.1 - 2.3e-102 343.1 0.0 2.9e-102 342.8 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-GRF PF06839.12 CDW56295.1 - 8.2e-25 86.6 25.4 3.5e-17 62.2 1.4 3.9 4 0 0 4 4 4 2 GRF zinc finger Toprim PF01751.22 CDW56295.1 - 1.1e-20 73.8 0.0 4.1e-20 71.9 0.0 2.0 2 0 0 2 2 2 1 Toprim domain zf-C4_Topoisom PF01396.19 CDW56295.1 - 3.6e-11 42.7 5.3 3.2e-09 36.4 0.2 3.5 3 0 0 3 3 3 2 Topoisomerase DNA binding C4 zinc finger Toprim_4 PF13662.6 CDW56295.1 - 0.12 12.8 0.0 0.44 11.0 0.0 1.9 2 0 0 2 2 2 0 Toprim domain zf-CCHC PF00098.23 CDW56295.1 - 4.9 7.4 11.2 0.34 11.1 2.4 3.3 3 0 0 3 3 3 0 Zinc knuckle MFS_1 PF07690.16 CDW56296.1 - 6.9e-39 133.8 53.2 1.8e-28 99.5 26.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily S4 PF01479.25 CDW56297.1 - 1.5e-05 24.6 6.2 0.82 9.4 0.0 5.6 6 0 0 6 6 6 2 S4 domain DUF4804 PF16062.5 CDW56297.1 - 0.003 16.5 0.0 4.1 6.1 0.0 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF4804) Spp-24 PF07448.11 CDW56297.1 - 0.014 15.6 0.4 27 5.0 0.0 3.8 3 0 0 3 3 3 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain Methyltransf_17 PF12692.7 CDW56297.1 - 0.046 13.7 0.2 54 3.7 0.0 4.3 5 0 0 5 5 5 0 S-adenosyl-L-methionine methyltransferase DUF3126 PF11324.8 CDW56297.1 - 0.15 11.9 1.3 43 4.0 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3126) Glyco_hydro_92 PF07971.12 CDW56297.1 - 0.3 9.9 8.6 15 4.3 0.0 5.2 7 0 0 7 7 7 0 Glycosyl hydrolase family 92 Cu_amine_oxidN1 PF07833.11 CDW56297.1 - 1.9 9.0 7.7 15 6.1 0.3 3.7 3 0 0 3 3 3 0 Copper amine oxidase N-terminal domain tRNA-synt_1b PF00579.25 CDW56298.1 - 2.9e-21 76.1 0.0 2.8e-20 72.8 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Pkinase PF00069.25 CDW56299.1 - 5.4e-08 32.5 0.0 1.1e-07 31.5 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 CDW56299.1 - 0.01 14.7 0.0 0.01 14.7 0.0 1.9 2 1 0 2 2 2 0 Fungal protein kinase Pkinase_Tyr PF07714.17 CDW56299.1 - 0.015 14.6 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Anillin PF08174.11 CDW56300.1 - 6.8e-05 23.3 0.2 0.00022 21.7 0.1 1.9 2 0 0 2 2 2 1 Cell division protein anillin Ets PF00178.22 CDW56302.1 - 4e-29 100.9 0.3 5e-29 100.6 0.3 1.1 1 0 0 1 1 1 1 Ets-domain EGF_2 PF07974.13 CDW56304.1 - 1.8e-08 34.6 48.2 0.0029 17.9 14.4 4.6 3 1 1 4 4 4 4 EGF-like domain EGF PF00008.27 CDW56304.1 - 6.3e-05 23.2 10.8 6.3e-05 23.2 10.8 5.2 5 1 0 5 5 5 3 EGF-like domain EGF_alliinase PF04863.13 CDW56304.1 - 0.026 14.9 6.3 0.026 14.9 6.3 4.6 3 1 1 4 4 4 0 Alliinase EGF-like domain hEGF PF12661.7 CDW56304.1 - 0.062 14.0 6.1 0.062 14.0 6.1 5.5 4 1 0 4 4 4 0 Human growth factor-like EGF Laminin_EGF PF00053.24 CDW56304.1 - 2.5 8.3 48.8 0.77 10.0 6.6 4.8 1 1 3 4 4 4 0 Laminin EGF domain CDC37_M PF08565.11 CDW56305.1 - 0.0067 16.3 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_N PF03234.14 CDW56305.1 - 0.018 15.9 0.3 0.018 15.9 0.3 2.8 3 0 0 3 3 3 0 Cdc37 N terminal kinase binding Complex1_LYR PF05347.15 CDW56307.1 - 2.9e-11 43.3 0.2 4.8e-11 42.5 0.2 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CDW56307.1 - 2.8e-06 28.0 1.9 3.6e-06 27.6 1.9 1.3 1 1 0 1 1 1 1 Complex1_LYR-like AD PF09793.9 CDW56308.1 - 4e-14 52.5 0.3 6.7e-14 51.8 0.3 1.3 1 0 0 1 1 1 1 Anticodon-binding domain MREG PF15812.5 CDW56308.1 - 0.066 13.5 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Melanoregulin WD40 PF00400.32 CDW56309.1 - 1.6e-26 92.0 10.3 1.1e-05 26.1 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56309.1 - 3.4e-07 30.5 0.1 0.59 10.5 0.0 3.8 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_C74 PF12387.8 CDW56309.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Pestivirus NS2 peptidase STI1 PF17830.1 CDW56309.1 - 1.8 8.5 4.0 19 5.3 0.1 2.6 2 0 0 2 2 2 0 STI1 domain RIO1 PF01163.22 CDW56310.1 - 2.9e-43 147.7 0.0 4.4e-43 147.1 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 CDW56310.1 - 6.1e-25 87.2 0.1 2.8e-24 85.1 0.1 2.0 2 0 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 CDW56310.1 - 1.8e-12 47.7 2.2 4.9e-06 26.6 0.3 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDW56310.1 - 1.5e-06 27.7 0.1 7.5e-06 25.4 0.1 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CDW56310.1 - 0.00066 19.1 0.0 0.0022 17.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain PIP49_C PF12260.8 CDW56310.1 - 0.0088 15.7 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 CX PF01705.19 CDW56311.1 - 2.7e-05 24.6 0.3 4.9e-05 23.8 0.3 1.4 1 0 0 1 1 1 1 CX module RRM_1 PF00076.22 CDW56312.1 - 5.5e-25 87.0 0.0 4.1e-07 29.7 0.0 3.4 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CDW56312.1 - 0.00071 19.6 0.2 7.9 6.6 0.0 3.2 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 CDW56312.1 - 0.074 13.1 0.2 0.33 11.0 0.0 2.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Chromo_shadow PF01393.19 CDW56313.1 - 1e-14 54.3 0.0 3e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 Chromo shadow domain Chromo PF00385.24 CDW56313.1 - 4.9e-10 39.2 0.0 4.5e-07 29.7 0.0 2.3 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 CDW56313.1 - 0.0016 18.6 0.3 1.3 9.2 0.1 2.5 2 0 0 2 2 2 2 Polycomb-like MTF2 factor 2 PALP PF00291.25 CDW56314.1 - 1e-79 268.0 2.5 1.3e-79 267.7 2.0 1.4 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme BAT PF15915.5 CDW56314.1 - 0.061 13.2 0.2 0.13 12.1 0.2 1.5 1 0 0 1 1 1 0 GAF and HTH_10 associated domain polyprenyl_synt PF00348.17 CDW56315.1 - 5.4e-58 196.0 0.0 7.1e-58 195.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DUF1068 PF06364.12 CDW56315.1 - 0.058 13.3 0.2 3.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) Ints3 PF10189.9 CDW56316.1 - 2e-74 249.6 1.4 4.7e-74 248.5 1.4 1.7 1 0 0 1 1 1 1 Integrator complex subunit 3 RRM_1 PF00076.22 CDW56317.1 - 3.5e-19 68.4 0.0 5.3e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW56317.1 - 0.038 14.1 0.0 0.066 13.3 0.0 1.6 1 1 0 1 1 1 0 RNA recognition motif RRM_5 PF13893.6 CDW56317.1 - 0.052 13.1 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 CDW56317.1 - 0.058 13.4 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 RL domain RNase_P_p30 PF01876.16 CDW56318.1 - 1e-39 136.3 0.5 1.7e-39 135.5 0.5 1.4 1 0 0 1 1 1 1 RNase P subunit p30 MTS PF05175.14 CDW56318.1 - 6.9e-08 32.2 0.0 1.8e-05 24.4 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 CDW56318.1 - 0.00047 19.6 0.0 0.00087 18.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDW56318.1 - 0.00078 20.1 0.0 0.0025 18.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CDW56318.1 - 0.002 17.9 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_24 PF13578.6 CDW56318.1 - 0.0071 17.4 0.0 0.02 15.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW56318.1 - 0.013 16.1 0.0 0.063 13.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 CDW56318.1 - 0.021 15.6 0.0 0.082 13.7 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 CDW56318.1 - 0.033 13.8 0.4 0.19 11.3 0.1 2.1 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase BHD_3 PF10405.9 CDW56318.1 - 0.098 13.1 0.0 0.61 10.5 0.0 2.2 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 3 PCMT PF01135.19 CDW56318.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pkinase PF00069.25 CDW56319.1 - 3.7e-48 164.2 0.0 5.8e-48 163.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56319.1 - 6.2e-43 146.9 0.0 7.8e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW56319.1 - 0.012 15.0 0.2 0.037 13.4 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family NHL PF01436.21 CDW56320.1 - 8.4e-51 167.5 13.9 1.2e-07 31.4 0.0 6.6 6 0 0 6 6 6 6 NHL repeat DUF5128 PF17170.4 CDW56320.1 - 2.4e-14 53.2 9.9 2.5e-05 23.6 0.1 4.1 1 1 2 4 4 4 4 6-bladed beta-propeller SGL PF08450.12 CDW56320.1 - 8.9e-13 48.4 0.1 0.00025 20.7 0.0 3.4 2 1 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region TolB_like PF15869.5 CDW56320.1 - 0.00046 19.5 0.1 1.6 7.9 0.1 3.0 1 1 0 2 2 2 2 TolB-like 6-blade propeller-like Lactonase PF10282.9 CDW56320.1 - 0.0042 16.4 1.1 0.53 9.5 0.0 3.1 1 1 2 3 3 3 1 Lactonase, 7-bladed beta-propeller DUF4934 PF16288.5 CDW56320.1 - 0.01 15.8 5.6 5.4 7.0 0.1 3.8 1 1 2 4 4 4 3 Domain of unknown function (DUF4934) SBBP PF06739.11 CDW56320.1 - 0.049 13.6 0.0 2.1 8.4 0.0 2.6 2 0 0 2 2 2 0 Beta-propeller repeat YlqD PF11068.8 CDW56320.1 - 0.091 13.1 7.3 5 7.5 0.1 2.9 2 1 1 3 3 3 0 YlqD protein Baculo_PEP_C PF04513.12 CDW56320.1 - 0.098 12.7 1.8 27 4.8 0.3 3.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus OB_Dis3 PF17849.1 CDW56320.1 - 0.13 12.3 0.0 13 5.9 0.0 3.4 4 0 0 4 4 3 0 Dis3-like cold-shock domain 2 (CSD2) FYVE PF01363.21 CDW56320.1 - 0.71 10.0 7.6 0.21 11.7 2.9 2.5 2 0 0 2 2 2 0 FYVE zinc finger zf-B_box PF00643.24 CDW56320.1 - 0.77 10.0 16.0 0.09 12.9 10.2 2.4 2 0 0 2 2 2 0 B-box zinc finger Phage_Mu_Gam PF07352.12 CDW56320.1 - 2.5 8.0 7.6 4.8 7.1 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein CdvA PF18822.1 CDW56320.1 - 7 6.5 8.2 22 4.9 0.3 2.6 2 0 0 2 2 2 0 CdvA-like coiled-coil domain UPF0016 PF01169.19 CDW56321.1 - 0.065 13.6 0.0 0.083 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein family UPF0016 DUF502 PF04367.13 CDW56321.1 - 0.14 12.1 0.0 0.39 10.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF502) EF1_GNE PF00736.19 CDW56322.1 - 8e-34 115.7 1.0 8e-34 115.7 1.0 2.3 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 CDW56322.1 - 2.2e-09 37.6 6.4 2.2e-09 37.6 6.4 2.8 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 CDW56322.1 - 0.094 12.9 0.3 0.4 10.9 0.0 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain YL1 PF05764.13 CDW56322.1 - 0.22 11.6 6.7 0.29 11.2 6.7 1.1 1 0 0 1 1 1 0 YL1 nuclear protein GST_C PF00043.25 CDW56322.1 - 0.31 11.3 1.6 5.5 7.3 0.1 2.8 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Y_phosphatase PF00102.27 CDW56323.1 - 1.1e-68 231.3 0.4 1.8e-68 230.6 0.4 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Receptor_IA-2 PF11548.8 CDW56323.1 - 0.0012 18.7 0.2 0.18 11.8 0.0 3.0 3 0 0 3 3 3 1 Protein-tyrosine phosphatase receptor IA-2 PTPlike_phytase PF14566.6 CDW56323.1 - 0.0081 16.3 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 CDW56323.1 - 0.014 15.4 0.0 0.05 13.6 0.0 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family DSPc PF00782.20 CDW56323.1 - 0.018 14.8 0.0 0.046 13.5 0.0 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Myotub-related PF06602.14 CDW56323.1 - 0.048 12.6 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Phage_Nu1 PF07471.12 CDW56323.1 - 0.11 12.3 0.1 0.26 11.0 0.1 1.7 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 Cyclin_N PF00134.23 CDW56324.1 - 2.5e-26 91.9 2.7 6.3e-25 87.4 0.5 3.2 3 1 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDW56324.1 - 7.7e-16 58.3 0.7 1.6e-15 57.2 0.7 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain DUF4539 PF15072.6 CDW56325.1 - 4.6e-09 36.2 0.0 7.6e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) WAP PF00095.21 CDW56326.1 - 4.7e-09 36.5 14.4 1.6e-08 34.8 2.2 4.4 2 2 2 4 4 4 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Dickkopf_N PF04706.12 CDW56326.1 - 1.3 9.5 43.9 0.22 12.0 5.1 4.3 3 1 1 4 4 4 0 Dickkopf N-terminal cysteine-rich region NKAIN PF05640.14 CDW56327.1 - 1.2e-32 112.9 13.9 1.8e-32 112.3 13.9 1.2 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein RCC1 PF00415.18 CDW56328.1 - 8.2e-07 29.6 0.0 1.6e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDW56328.1 - 0.19 11.6 0.2 21 5.1 0.1 2.4 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat XPG_I PF00867.18 CDW56329.1 - 1.7e-27 95.6 0.1 2.9e-27 94.8 0.1 1.4 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 CDW56329.1 - 2e-05 25.1 0.0 4.4e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold GCHY-1 PF02649.14 CDW56329.1 - 0.073 12.6 0.0 1.4 8.4 0.0 2.1 2 0 0 2 2 2 0 Type I GTP cyclohydrolase folE2 PDZ PF00595.24 CDW56330.1 - 1e-60 202.0 7.3 5.5e-20 71.5 0.1 3.3 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 CDW56330.1 - 1.8e-47 161.4 0.0 3e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ_6 PF17820.1 CDW56330.1 - 6.2e-20 70.8 6.0 9.7e-09 34.9 0.0 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 CDW56330.1 - 2.8e-12 46.8 3.7 0.00049 20.4 0.2 3.5 3 0 0 3 3 3 3 PDZ domain SH3_2 PF07653.17 CDW56330.1 - 4.8e-06 26.2 0.0 1.7e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW56330.1 - 4.8e-06 26.1 0.0 1.5e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CDW56330.1 - 0.0022 17.8 0.1 0.0074 16.1 0.1 2.0 1 0 0 1 1 1 1 Variant SH3 domain DUF5529 PF17669.1 CDW56330.1 - 0.22 11.6 0.0 0.64 10.0 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5529) TSP_1 PF00090.19 CDW56331.1 - 0.00081 19.6 6.0 0.0028 17.8 6.0 2.0 1 0 0 1 1 1 1 Thrombospondin type 1 domain EPF PF17181.4 CDW56332.1 - 0.63 10.1 6.1 3.2 7.8 0.5 2.6 2 0 0 2 2 2 0 Epidermal patterning factor proteins BING4CT PF08149.11 CDW56333.1 - 5.4e-36 122.3 0.0 1.5e-35 120.8 0.0 1.8 2 0 0 2 2 2 1 BING4CT (NUC141) domain WD40 PF00400.32 CDW56333.1 - 0.00027 21.7 0.1 0.0069 17.2 0.0 3.3 4 1 1 5 5 5 1 WD domain, G-beta repeat MMS1_N PF10433.9 CDW56333.1 - 0.11 11.1 0.0 0.21 10.2 0.0 1.4 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term RAMA PF18755.1 CDW56334.1 - 2.3e-08 34.4 0.0 4.1e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated BTB PF00651.31 CDW56335.1 - 5.1e-09 36.3 0.9 1.9e-08 34.5 0.0 2.4 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.15 CDW56335.1 - 0.00053 20.0 4.6 0.91 9.6 0.2 4.3 3 1 1 4 4 4 2 BTB And C-terminal Kelch Vinculin PF01044.19 CDW56336.1 - 1.9e-241 804.3 42.2 2.7e-168 562.2 22.7 2.9 1 1 1 2 2 2 2 Vinculin family Ribul_P_3_epim PF00834.19 CDW56336.1 - 0.023 14.1 0.0 0.074 12.4 0.0 1.8 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family FAM110_C PF14160.6 CDW56336.1 - 0.058 14.5 0.2 0.24 12.5 0.2 2.1 1 0 0 1 1 1 0 Centrosome-associated C terminus BTB PF00651.31 CDW56337.1 - 0.091 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain TRAPP PF04051.16 CDW56338.1 - 2.9e-24 85.4 0.0 3.4e-24 85.2 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Lectin_leg-like PF03388.13 CDW56338.1 - 0.024 14.0 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Legume-like lectin family ABC2_membrane PF01061.24 CDW56340.1 - 7.4e-37 126.8 23.9 1.4e-36 126.0 23.9 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CDW56340.1 - 4e-19 69.5 0.0 6.8e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDW56340.1 - 3.1e-06 26.8 0.1 3.9e-05 23.2 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDW56340.1 - 6.6e-05 22.9 0.3 0.0005 20.0 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 CDW56340.1 - 0.00091 19.1 0.1 1.4 8.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 CDW56340.1 - 0.0018 17.5 23.1 0.0028 16.8 23.1 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein MMR_HSR1 PF01926.23 CDW56340.1 - 0.0018 18.3 0.2 0.0038 17.3 0.2 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CDW56340.1 - 0.0033 17.8 0.0 0.0058 17.0 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDW56340.1 - 0.0073 16.0 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDW56340.1 - 0.025 15.1 0.0 0.048 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDW56340.1 - 0.047 14.0 0.1 0.13 12.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDW56340.1 - 0.084 13.1 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 CDW56340.1 - 0.16 12.0 0.1 0.28 11.2 0.1 1.4 1 0 0 1 1 1 0 Dynamin family cobW PF02492.19 CDW56340.1 - 0.18 11.4 0.1 0.27 10.8 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CDW56340.1 - 0.2 11.4 0.0 11 5.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain ARGLU PF15346.6 CDW56341.1 - 7.3e-26 90.8 24.5 7.3e-26 90.8 24.5 2.4 2 1 0 2 2 2 1 Arginine and glutamate-rich 1 UPF0449 PF15136.6 CDW56341.1 - 0.026 15.0 6.7 0.026 15.0 6.7 2.7 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DUF5363 PF17320.2 CDW56341.1 - 0.031 14.1 0.0 0.086 12.7 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5363) MYT1 PF08474.11 CDW56341.1 - 0.043 13.8 0.4 0.043 13.8 0.4 2.1 2 0 0 2 2 2 0 Myelin transcription factor 1 FapA PF03961.13 CDW56341.1 - 0.64 8.6 7.6 0.89 8.1 7.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A HlyD_2 PF12700.7 CDW56341.1 - 0.79 8.4 8.0 1.1 7.9 8.0 1.1 1 0 0 1 1 1 0 HlyD family secretion protein KCNQ2_u3 PF16642.5 CDW56341.1 - 1.1 10.2 5.0 0.78 10.8 0.5 2.4 1 1 1 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Folate_carrier PF01770.18 CDW56342.1 - 1.5e-45 155.7 7.9 2.7e-45 154.9 7.9 1.4 1 0 0 1 1 1 1 Reduced folate carrier MFS_1 PF07690.16 CDW56342.1 - 6.7e-05 22.0 11.4 6.7e-05 22.0 11.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily FERM_M PF00373.18 CDW56343.1 - 3.6e-16 59.6 0.0 9.4e-16 58.3 0.0 1.7 2 0 0 2 2 2 1 FERM central domain FERM_C PF09380.10 CDW56343.1 - 1.5e-13 50.9 0.0 2.8e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.11 CDW56343.1 - 0.0015 18.6 0.6 0.0029 17.6 0.6 1.5 1 0 0 1 1 1 1 FERM adjacent (FA) ADH_zinc_N_2 PF13602.6 CDW56344.1 - 7.8e-21 75.5 0.0 1.6e-20 74.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CDW56344.1 - 2.9e-11 43.4 0.1 5.3e-11 42.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW56344.1 - 4.8e-08 32.8 0.0 1.6e-07 31.2 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain WD40 PF00400.32 CDW56345.1 - 4.5e-11 43.1 2.8 0.00033 21.4 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat DUF2555 PF10742.9 CDW56346.1 - 0.045 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) DUF1180 PF06679.12 CDW56346.1 - 6.6 7.1 8.3 15 5.9 8.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Motile_Sperm PF00635.26 CDW56347.1 - 2.5e-10 40.2 0.0 7e-10 38.7 0.0 1.7 1 1 1 2 2 2 1 MSP (Major sperm protein) domain DUF4980 PF16352.5 CDW56347.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4980) Motile_Sperm PF00635.26 CDW56348.1 - 5.7e-09 35.8 0.2 8.6e-09 35.2 0.2 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain V-ATPase_G PF03179.15 CDW56349.1 - 4.3e-32 110.8 15.4 4.9e-32 110.6 15.4 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 CDW56349.1 - 0.017 15.5 11.3 0.022 15.2 11.3 1.2 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 CDW56349.1 - 0.024 14.1 19.1 0.039 13.4 18.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) XRN_M PF17846.1 CDW56349.1 - 1.8 7.5 7.1 2 7.3 7.1 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Goodbye PF17109.5 CDW56349.1 - 1.9 9.0 6.2 0.38 11.2 1.7 1.9 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain ATP-synt_B PF00430.18 CDW56349.1 - 4.4 7.4 18.6 12 6.0 18.7 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF883 PF05957.13 CDW56349.1 - 6.5 7.4 11.0 36 5.1 11.0 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Connexin PF00029.19 CDW56349.1 - 6.7 6.4 6.4 7.9 6.2 6.4 1.1 1 0 0 1 1 1 0 Connexin Acyltransferase PF01553.21 CDW56350.1 - 1.8e-15 56.8 0.0 3.5e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Oxidored_q2 PF00420.24 CDW56350.1 - 0.15 11.7 1.7 0.3 10.7 1.7 1.4 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L GTP_EFTU PF00009.27 CDW56351.1 - 8.4e-25 87.5 0.2 1.4e-24 86.8 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW56351.1 - 6.9e-06 26.1 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW56351.1 - 8.8e-05 22.0 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU_D2 PF03144.25 CDW56351.1 - 0.0001 22.6 0.2 0.00025 21.4 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 S4 PF01479.25 CDW56352.1 - 3.8e-07 29.7 0.0 7.4e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 S4 domain Motile_Sperm PF00635.26 CDW56353.1 - 4.8e-09 36.0 0.0 1.1e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Peptidase_M41 PF01434.18 CDW56354.1 - 3.3e-54 183.6 1.9 4.9e-41 140.7 0.0 2.3 1 1 1 2 2 2 2 Peptidase family M41 AAA PF00004.29 CDW56354.1 - 1.3e-44 151.8 0.1 3.2e-44 150.6 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW56354.1 - 7.6e-15 54.4 0.1 1.7e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 CDW56354.1 - 1.8e-08 34.7 1.1 2.8e-08 34.1 0.1 1.8 2 0 0 2 2 1 1 FtsH Extracellular AAA_5 PF07728.14 CDW56354.1 - 3.3e-05 23.9 0.0 0.0002 21.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDW56354.1 - 0.00021 21.5 0.1 0.041 14.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CDW56354.1 - 0.0012 18.6 0.0 0.0077 16.0 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDW56354.1 - 0.0026 17.9 0.0 0.015 15.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 CDW56354.1 - 0.0032 16.7 0.0 0.0062 15.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 CDW56354.1 - 0.0057 17.0 0.1 0.24 11.8 0.1 2.8 1 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 CDW56354.1 - 0.011 15.4 0.2 0.028 14.2 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDW56354.1 - 0.012 15.0 0.2 0.037 13.4 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CDW56354.1 - 0.015 15.5 0.6 0.18 12.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDW56354.1 - 0.029 14.9 0.1 0.4 11.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDW56354.1 - 0.035 13.7 0.5 0.37 10.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 CDW56354.1 - 0.037 14.5 0.6 4.5 7.8 0.1 2.7 2 0 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 CDW56354.1 - 0.05 13.8 0.0 0.16 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDW56354.1 - 0.061 13.4 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CDW56354.1 - 0.073 13.5 1.6 0.27 11.6 0.0 2.6 3 0 0 3 3 2 0 AAA domain TRAPPC-Trs85 PF12739.7 CDW56355.1 - 2.8e-95 319.7 0.3 3.7e-95 319.3 0.3 1.1 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SNAP PF14938.6 CDW56355.1 - 0.00071 19.1 0.3 0.00071 19.1 0.3 1.8 2 0 0 2 2 2 1 Soluble NSF attachment protein, SNAP Peptidase_C54 PF03416.19 CDW56356.1 - 2.9e-81 272.9 0.0 3.6e-81 272.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 CDW56356.1 - 0.026 14.0 0.1 0.22 11.0 0.1 2.1 2 0 0 2 2 2 0 Peptidase family C78 Dynein_heavy PF03028.15 CDW56356.1 - 0.14 12.3 0.1 1.3 9.1 0.0 2.5 3 0 0 3 3 3 0 Dynein heavy chain region D6 P-loop domain Autophagy_act_C PF03987.15 CDW56357.1 - 8.7e-18 64.7 0.6 8.7e-18 64.7 0.6 1.6 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain PMP22_Claudin PF00822.20 CDW56358.1 - 0.33 10.8 12.3 5.6 6.8 12.4 2.1 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin family CPG4 PF15481.6 CDW56359.1 - 0.00043 20.9 3.6 0.00043 20.9 3.6 2.1 2 0 0 2 2 2 1 Chondroitin proteoglycan 4 Suc_Fer-like PF06999.12 CDW56359.1 - 0.028 14.3 0.6 0.03 14.2 0.6 1.2 1 0 0 1 1 1 0 Sucrase/ferredoxin-like Mrr_N PF14338.6 CDW56359.1 - 0.2 11.8 0.2 1 9.6 0.0 2.0 2 0 0 2 2 2 0 Mrr N-terminal domain LINES_N PF14694.6 CDW56360.1 - 0.0034 16.9 0.6 0.0034 16.9 0.6 2.1 2 0 0 2 2 2 1 Lines N-terminus Homeodomain PF00046.29 CDW56361.1 - 5.8e-19 67.7 7.9 6e-19 67.6 5.8 1.9 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW56361.1 - 0.004 17.0 0.2 0.0087 15.9 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 CDW56361.1 - 0.0075 15.7 0.3 0.014 14.8 0.3 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez CBM60 PF16841.5 CDW56361.1 - 0.093 13.2 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 Ca-dependent carbohydrate-binding module xylan-binding NLBH PF05211.12 CDW56361.1 - 0.094 12.3 0.1 0.11 12.0 0.1 1.1 1 0 0 1 1 1 0 Neuraminyllactose-binding hemagglutinin precursor (NLBH) DM13 PF10517.9 CDW56362.1 - 2.2e-36 124.6 0.0 1.7e-18 67.1 0.0 2.4 2 0 0 2 2 2 2 Electron transfer DM13 DM13 PF10517.9 CDW56363.1 - 3.4e-10 40.4 0.0 0.0011 19.5 0.0 2.6 2 0 0 2 2 2 2 Electron transfer DM13 DM13 PF10517.9 CDW56364.1 - 0.0021 18.6 0.0 0.029 14.9 0.0 2.7 3 0 0 3 3 3 1 Electron transfer DM13 GH115_C PF17829.1 CDW56364.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Gylcosyl hydrolase family 115 C-terminal domain ubiquitin PF00240.23 CDW56365.1 - 3.1e-254 821.4 43.2 9.8e-34 114.9 0.3 9.0 9 0 0 9 9 9 9 Ubiquitin family Rad60-SLD PF11976.8 CDW56365.1 - 8.9e-121 393.9 39.8 7.7e-16 57.7 0.3 9.0 9 0 0 9 9 9 9 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CDW56365.1 - 6.2e-47 158.0 22.3 6.7e-05 23.3 0.1 9.8 8 6 0 8 8 8 8 Ubiquitin-like domain TBK1_ULD PF18396.1 CDW56365.1 - 2.6e-30 104.2 13.2 0.042 13.8 0.0 8.2 8 0 0 8 8 8 8 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CDW56365.1 - 3.5e-21 75.4 13.4 0.087 12.9 0.0 8.8 8 1 0 8 8 8 6 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CDW56365.1 - 3.8e-20 72.1 18.8 0.099 13.0 0.1 8.0 7 1 0 8 8 7 6 Ubiquitin-like domain DUF2407 PF10302.9 CDW56365.1 - 6.8e-19 68.4 5.8 0.67 10.6 0.0 8.0 1 1 6 8 8 8 6 DUF2407 ubiquitin-like domain UDP-g_GGTase PF06427.11 CDW56365.1 - 1.2e-09 38.3 13.5 13 6.0 0.0 7.6 8 0 0 8 8 8 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF2870 PF11069.8 CDW56365.1 - 1.2e-08 35.2 0.1 70 3.9 0.0 7.8 8 0 0 8 8 8 0 Protein of unknown function (DUF2870) RBD PF02196.15 CDW56365.1 - 3.5e-08 33.4 0.0 85 3.3 0.0 7.9 8 0 0 8 8 8 0 Raf-like Ras-binding domain Ubiquitin_4 PF18036.1 CDW56365.1 - 4.9e-07 29.7 45.0 27 4.9 0.3 14.3 14 1 0 14 14 14 0 Ubiquitin-like domain ORF11CD3 PF10549.9 CDW56365.1 - 1.5e-06 28.2 0.0 2.1e+02 2.1 0.0 8.1 7 0 0 7 7 7 0 ORF11CD3 domain Big_7 PF17957.1 CDW56365.1 - 1.7e-06 28.7 0.2 2.9e+02 2.3 0.0 7.6 8 0 0 8 8 8 0 Bacterial Ig domain DUF969 PF06149.12 CDW56365.1 - 1.9e-06 27.5 1.0 52 3.2 0.0 6.3 7 0 0 7 7 7 0 Protein of unknown function (DUF969) DUF3861 PF12977.7 CDW56365.1 - 2.2e-06 27.7 7.4 55 4.0 0.0 7.9 8 0 0 8 8 8 0 Domain of Unknown Function with PDB structure (DUF3861) TOBE_2 PF08402.10 CDW56365.1 - 8.1e-05 22.7 0.1 1.4e+02 2.7 0.0 6.8 7 0 0 7 7 7 0 TOBE domain TraK PF06586.11 CDW56365.1 - 0.00015 21.5 2.7 1.9e+02 1.6 0.0 7.2 8 0 0 8 8 8 0 TraK protein CorA PF01544.18 CDW56365.1 - 0.029 13.7 9.3 83 2.4 0.0 7.0 8 0 0 8 8 8 0 CorA-like Mg2+ transporter protein Phage_sheath_1N PF17481.2 CDW56365.1 - 0.37 11.3 14.2 1.3e+02 3.1 1.4 7.0 2 2 2 4 4 4 0 Phage tail sheath protein beta-sandwich domain ProRS-C_2 PF09181.10 CDW56365.1 - 1 9.6 14.8 1.8e+02 2.4 0.1 7.3 8 0 0 8 8 8 0 Prolyl-tRNA synthetase, C-terminal FlgD_ig PF13860.6 CDW56365.1 - 1.8 8.5 20.2 89 3.1 0.1 7.7 8 0 0 8 8 8 0 FlgD Ig-like domain Pkinase PF00069.25 CDW56366.1 - 3.8e-61 206.8 0.0 9.1e-61 205.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56366.1 - 3.1e-31 108.6 0.3 1.2e-21 77.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW56366.1 - 5.1e-06 25.7 0.1 7.5e-06 25.1 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW56366.1 - 0.00012 21.5 0.4 0.0052 16.1 0.0 2.4 2 1 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 CDW56366.1 - 0.00047 20.8 0.1 0.001 19.8 0.1 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.14 CDW56366.1 - 0.0017 17.8 0.0 0.0042 16.5 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW56366.1 - 0.0033 17.4 3.1 0.04 13.8 0.1 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDW56366.1 - 0.091 12.4 0.1 0.091 12.4 0.1 2.0 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.20 CDW56366.1 - 0.15 11.6 0.1 0.68 9.5 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 CDW56366.1 - 0.16 11.0 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Mtc PF03820.17 CDW56367.1 - 1.9e-124 414.8 1.0 3.1e-124 414.1 1.0 1.3 1 1 0 1 1 1 1 Tricarboxylate carrier RPAP1_C PF08620.10 CDW56367.1 - 0.031 14.4 0.4 0.062 13.4 0.4 1.5 1 0 0 1 1 1 0 RPAP1-like, C-terminal CBFB_NFYA PF02045.15 CDW56368.1 - 3.7e-25 88.3 5.1 4.8e-25 87.9 5.1 1.1 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Arf PF00025.21 CDW56369.1 - 1.2e-72 243.1 0.0 1.3e-72 242.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW56369.1 - 1.6e-15 57.4 0.1 2.1e-15 57.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDW56369.1 - 1.1e-12 47.8 0.0 1.3e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CDW56369.1 - 3e-11 43.1 0.9 1.4e-07 31.0 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 CDW56369.1 - 2.9e-10 39.9 0.0 3.3e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CDW56369.1 - 1.5e-09 37.6 0.0 1.8e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW56369.1 - 6.8e-06 26.1 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 CDW56369.1 - 0.0059 15.6 0.1 0.22 10.4 0.0 2.4 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CDW56369.1 - 0.014 15.9 0.0 0.019 15.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 CDW56369.1 - 0.037 13.6 0.3 0.34 10.4 0.0 2.2 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CDW56369.1 - 0.046 13.5 0.2 4.8 6.9 0.1 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 CDW56369.1 - 0.072 13.6 0.2 0.14 12.6 0.2 1.7 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.18 CDW56369.1 - 0.074 12.6 1.3 0.58 9.7 1.3 2.4 1 1 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 CDW56369.1 - 0.08 12.5 0.3 8.3 6.0 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SelB-wing_2 PF09106.11 CDW56369.1 - 0.13 12.5 0.1 0.78 10.0 0.0 1.9 2 0 0 2 2 2 0 Elongation factor SelB, winged helix Ig_3 PF13927.6 CDW56370.1 - 7e-51 170.7 3.0 4.6e-14 52.8 0.0 5.6 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 CDW56370.1 - 4.9e-35 119.7 1.0 1.3e-10 41.4 0.0 5.7 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 CDW56370.1 - 1.4e-32 111.6 0.1 2.3e-09 37.2 0.1 5.9 4 1 1 5 5 5 3 Immunoglobulin I-set domain ig PF00047.25 CDW56370.1 - 7.8e-23 80.5 0.2 7.9e-08 32.4 0.0 6.1 5 2 0 5 5 5 4 Immunoglobulin domain C2-set_2 PF08205.12 CDW56370.1 - 9.1e-20 70.5 1.1 1.6e-12 47.3 0.0 5.5 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain V-set PF07686.17 CDW56370.1 - 2.1e-14 53.6 7.0 2e-06 27.9 0.3 6.9 6 3 1 7 7 7 2 Immunoglobulin V-set domain C1-set PF07654.15 CDW56370.1 - 1.9e-11 44.2 0.2 0.0046 17.3 0.0 5.9 5 2 1 6 6 6 2 Immunoglobulin C1-set domain Ig_4 PF16680.5 CDW56370.1 - 0.0027 17.9 0.0 0.55 10.5 0.0 3.8 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Cadherin_tail PF15974.5 CDW56370.1 - 0.078 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region TIL PF01826.17 CDW56372.1 - 1.5e-15 57.1 16.1 1.9e-15 56.9 16.1 1.1 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 CDW56372.1 - 0.016 15.2 1.1 0.016 15.2 1.1 2.5 2 1 0 2 2 2 0 Complement Clr-like EGF-like Tme5_EGF_like PF09064.10 CDW56372.1 - 0.69 9.9 9.5 17 5.4 9.5 2.5 1 1 0 1 1 1 0 Thrombomodulin like fifth domain, EGF-like WD40 PF00400.32 CDW56373.1 - 1.5e-36 123.7 22.2 2.4e-06 28.1 0.9 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 CDW56373.1 - 1.7e-10 40.6 0.4 4e-10 39.4 0.4 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CDW56373.1 - 4.5e-10 39.7 1.1 0.037 14.3 0.0 4.9 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW56373.1 - 2.3e-07 30.4 0.3 0.012 15.0 0.0 2.9 1 1 1 3 3 3 2 WD40-like domain F-box PF00646.33 CDW56373.1 - 1.8e-05 24.4 0.4 4.3e-05 23.3 0.4 1.7 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 CDW56373.1 - 7.2e-05 21.6 5.0 0.41 9.2 0.1 3.7 2 1 2 4 4 4 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 CDW56373.1 - 0.0003 20.8 0.1 5.8 7.0 0.0 4.2 2 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region DUF5046 PF16465.5 CDW56373.1 - 0.0026 17.3 0.3 4.6 6.6 0.0 3.5 1 1 3 4 4 4 2 Domain of unknown function (DUF5046) 120_Rick_ant PF12574.8 CDW56373.1 - 0.016 14.4 0.1 0.22 10.7 0.0 2.0 1 1 1 2 2 2 0 120 KDa Rickettsia surface antigen Prot_ATP_ID_OB PF16450.5 CDW56373.1 - 0.12 12.3 0.3 32 4.6 0.0 3.3 2 1 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain tRNA-synt_2b PF00587.25 CDW56374.1 - 2.2e-28 99.5 0.0 5.4e-28 98.2 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) PPR_2 PF13041.6 CDW56374.1 - 4.5e-15 55.6 0.3 7.1e-08 32.5 0.0 4.2 4 0 0 4 4 4 3 PPR repeat family PPR_3 PF13812.6 CDW56374.1 - 1.2e-09 38.1 0.0 3e-05 24.0 0.0 3.3 1 1 2 3 3 3 3 Pentatricopeptide repeat domain PPR_long PF17177.4 CDW56374.1 - 4.3e-06 26.3 0.0 0.0047 16.3 0.0 2.4 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP adh_short_C2 PF13561.6 CDW56374.1 - 1.6e-05 24.6 0.0 3.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDW56374.1 - 1.8e-05 24.3 0.1 4.1e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 short chain dehydrogenase PPR_1 PF12854.7 CDW56374.1 - 0.00079 19.1 0.2 0.56 10.0 0.0 3.6 3 0 0 3 3 3 1 PPR repeat RPM2 PF08579.11 CDW56374.1 - 0.0016 18.9 0.0 0.3 11.5 0.0 3.3 2 1 1 3 3 3 1 Mitochondrial ribonuclease P subunit (RPM2) Epimerase PF01370.21 CDW56374.1 - 0.0033 16.9 0.3 0.17 11.3 0.0 2.7 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family PPR PF01535.20 CDW56374.1 - 0.0084 16.3 0.6 0.18 12.1 0.0 3.6 4 0 0 4 4 4 1 PPR repeat RmlD_sub_bind PF04321.17 CDW56374.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain tRNA-synt_2d PF01409.20 CDW56374.1 - 0.12 11.9 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) Homeodomain PF00046.29 CDW56375.1 - 5.7e-21 74.1 6.2 1.1e-20 73.2 6.2 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW56375.1 - 0.0043 16.9 0.4 0.013 15.3 0.2 2.0 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 CDW56375.1 - 0.021 14.3 0.5 0.041 13.3 0.5 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez FAM60A PF15396.6 CDW56375.1 - 0.028 14.4 0.8 0.045 13.7 0.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A zf-H2C2_5 PF13909.6 CDW56376.1 - 2.1e-11 43.3 21.5 4e-05 23.3 2.2 4.8 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 CDW56376.1 - 2.8e-08 33.8 28.1 5.1e-05 23.5 0.9 5.1 5 1 0 5 5 5 2 Zinc-finger double domain Actin_micro PF17003.5 CDW56376.1 - 0.00034 19.9 3.7 0.073 12.2 0.2 2.8 3 0 0 3 3 3 2 Putative actin-like family DUF2652 PF10851.8 CDW56376.1 - 0.0092 16.1 0.4 1.8 8.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2652) OrfB_Zn_ribbon PF07282.11 CDW56376.1 - 0.046 13.6 4.9 0.55 10.2 0.7 2.7 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zf-C2H2 PF00096.26 CDW56376.1 - 0.29 11.7 20.6 0.35 11.4 1.7 4.5 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CDW56376.1 - 1.2 9.5 13.7 3.9 7.9 0.2 4.5 3 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) RNA_POL_M_15KD PF02150.16 CDW56376.1 - 1.4 8.9 9.7 2.9 7.8 0.1 3.8 4 0 0 4 4 4 0 RNA polymerases M/15 Kd subunit ATG16 PF08614.11 CDW56378.1 - 7.8e-10 39.3 117.3 0.0001 22.6 18.6 9.6 4 2 7 11 11 11 6 Autophagy protein 16 (ATG16) AMPK1_CBM PF16561.5 CDW56378.1 - 1.4e-09 38.1 0.1 3.9e-09 36.6 0.1 1.8 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase HOOK PF05622.12 CDW56378.1 - 9.7e-06 24.0 115.9 9e-05 20.8 23.8 6.6 1 1 6 7 7 7 4 HOOK protein Fez1 PF06818.15 CDW56378.1 - 0.0006 20.3 119.4 0.25 11.8 10.4 7.9 1 1 5 7 7 7 3 Fez1 DUF4200 PF13863.6 CDW56378.1 - 0.00081 19.8 20.0 0.00081 19.8 20.0 11.4 4 2 5 10 10 10 2 Domain of unknown function (DUF4200) Tropomyosin PF00261.20 CDW56378.1 - 0.00083 18.8 22.7 0.0064 15.9 21.4 8.0 2 2 4 6 6 5 4 Tropomyosin TPR_MLP1_2 PF07926.12 CDW56378.1 - 0.0017 18.4 7.5 0.0017 18.4 7.5 11.9 3 3 5 9 9 8 1 TPR/MLP1/MLP2-like protein Laminin_II PF06009.12 CDW56378.1 - 0.0027 17.7 5.7 0.0027 17.7 5.7 8.3 3 1 4 8 8 8 1 Laminin Domain II MscS_porin PF12795.7 CDW56378.1 - 0.0051 16.4 84.1 0.014 15.0 13.7 7.6 1 1 5 6 6 5 2 Mechanosensitive ion channel porin domain DUF745 PF05335.13 CDW56378.1 - 0.0057 16.4 2.2 0.0057 16.4 2.2 7.5 4 2 4 9 9 7 5 Protein of unknown function (DUF745) AAA_13 PF13166.6 CDW56378.1 - 0.0063 15.2 77.7 0.03 13.0 16.6 6.2 1 1 4 6 6 6 3 AAA domain FPP PF05911.11 CDW56378.1 - 0.0064 14.8 122.0 0.026 12.8 11.1 6.8 1 1 5 7 7 7 3 Filament-like plant protein, long coiled-coil TMF_TATA_bd PF12325.8 CDW56378.1 - 0.0064 16.7 3.4 0.0064 16.7 3.4 11.7 3 2 8 11 11 11 3 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 CDW56378.1 - 0.008 15.1 115.6 0.011 14.6 16.2 7.9 2 2 6 8 8 8 3 Spc7 kinetochore protein PKcGMP_CC PF16808.5 CDW56378.1 - 0.028 14.3 74.8 0.046 13.6 0.0 13.7 13 1 1 14 14 13 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ERM PF00769.19 CDW56378.1 - 0.13 12.0 120.9 0.19 11.5 8.5 7.7 1 1 4 6 6 6 0 Ezrin/radixin/moesin family ADIP PF11559.8 CDW56378.1 - 0.34 11.0 106.6 0.65 10.1 13.0 10.2 4 2 5 11 11 11 0 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 CDW56378.1 - 0.46 9.9 111.3 0.021 14.3 13.0 7.5 1 1 7 8 8 8 0 Golgin subfamily A member 5 GAS PF13851.6 CDW56378.1 - 1.3 8.4 119.6 0.011 15.2 13.3 9.2 1 1 7 9 9 9 0 Growth-arrest specific micro-tubule binding HIP1_clath_bdg PF16515.5 CDW56378.1 - 1.8 9.2 101.1 0.16 12.6 8.2 11.8 1 1 9 13 13 12 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3584 PF12128.8 CDW56378.1 - 3.2 5.2 108.1 0.0064 14.1 6.0 5.0 1 1 3 5 5 5 0 Protein of unknown function (DUF3584) Flagellin_C PF00700.21 CDW56378.1 - 3.3 8.1 9.0 8.2 6.9 0.2 5.4 4 1 1 5 5 5 0 Bacterial flagellin C-terminal helical region CALCOCO1 PF07888.11 CDW56378.1 - 5.2 5.8 120.0 0.36 9.7 10.4 6.0 1 1 3 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like Taxilin PF09728.9 CDW56378.1 - 6.1 5.9 99.9 0.15 11.2 12.4 5.5 2 1 4 6 6 6 0 Myosin-like coiled-coil protein Cyt-b5 PF00173.28 CDW56379.1 - 1e-23 83.2 0.0 1.4e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Jiv90 PF14901.6 CDW56379.1 - 0.015 15.4 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Cleavage inducing molecular chaperone V-ATPase_H_C PF11698.8 CDW56379.1 - 0.061 13.4 0.0 0.074 13.2 0.0 1.1 1 0 0 1 1 1 0 V-ATPase subunit H RestrictionSfiI PF11487.8 CDW56379.1 - 0.089 12.7 0.0 0.15 11.9 0.0 1.4 1 1 0 1 1 1 0 Type II restriction enzyme SfiI GTP1_OBG PF01018.22 CDW56380.1 - 3.4e-24 85.2 1.4 4.7e-14 52.3 0.1 2.1 1 1 1 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 CDW56380.1 - 4.3e-21 75.1 0.0 7e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW56380.1 - 2.1e-09 37.1 0.0 9.6e-09 35.0 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 CDW56380.1 - 4.1e-06 26.3 0.0 1e-05 25.0 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW56380.1 - 0.00057 19.3 0.0 0.00088 18.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CDW56380.1 - 0.02 14.4 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NOG1 PF06858.14 CDW56380.1 - 0.023 14.5 0.1 0.045 13.5 0.1 1.5 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) ABC_tran PF00005.27 CDW56380.1 - 0.023 15.2 0.0 0.094 13.2 0.0 1.9 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 CDW56380.1 - 0.048 13.4 0.0 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 CDW56380.1 - 0.13 12.3 0.0 12 5.9 0.0 2.3 1 1 1 2 2 2 0 Dynamin family EamA PF00892.20 CDW56381.1 - 1.2e-13 51.4 29.5 2.8e-07 30.8 16.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family DUF3278 PF11683.8 CDW56381.1 - 0.66 10.1 8.0 1.1 9.3 1.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3278) HGTP_anticodon PF03129.20 CDW56382.1 - 1.3e-19 70.1 0.0 1.2e-18 67.0 0.0 2.4 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CDW56382.1 - 7e-11 42.4 0.0 1.8e-10 41.1 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS PF00458.20 CDW56382.1 - 0.61 10.3 6.8 3.8 7.7 5.0 2.4 2 0 0 2 2 2 0 WHEP-TRS domain Ank_2 PF12796.7 CDW56383.1 - 1.5e-111 365.2 20.3 4.2e-17 62.5 0.1 8.9 1 1 9 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 CDW56383.1 - 1.5e-75 246.6 29.1 1.6e-07 31.5 0.1 15.8 15 0 0 15 15 15 14 Ankyrin repeat Ank_5 PF13857.6 CDW56383.1 - 6.1e-71 233.6 25.9 1.9e-11 43.9 0.4 12.5 3 3 9 13 13 13 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW56383.1 - 2.4e-64 205.6 20.8 0.00072 19.8 0.0 15.0 16 0 0 16 16 16 13 Ankyrin repeat Ank_4 PF13637.6 CDW56383.1 - 7e-62 205.1 24.8 1.7e-07 31.7 0.1 13.5 4 2 11 15 15 15 14 Ankyrin repeats (many copies) AAA_16 PF13191.6 CDW56383.1 - 0.00022 21.6 0.0 0.00088 19.7 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CDW56383.1 - 0.00096 19.1 0.0 0.0073 16.2 0.0 2.6 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 CDW56383.1 - 0.051 13.5 0.0 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea 7tm_2 PF00002.24 CDW56384.1 - 3.7e-25 88.6 6.0 3.2e-21 75.7 1.0 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) Pkinase PF00069.25 CDW56385.1 - 5e-65 219.5 0.0 7.1e-65 219.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56385.1 - 3.6e-30 105.1 0.0 4.8e-30 104.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW56385.1 - 0.00013 21.4 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDW56385.1 - 0.0024 17.2 0.0 0.0057 16.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CDW56385.1 - 0.0027 17.3 0.2 0.0053 16.4 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 CDW56385.1 - 0.0029 17.6 0.0 0.012 15.6 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDW56385.1 - 0.0058 15.6 0.1 0.008 15.2 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain PET PF06297.14 CDW56386.1 - 2.6e-29 101.4 0.5 4.2e-29 100.7 0.5 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 CDW56386.1 - 7.6e-21 74.1 45.1 2.1e-08 34.2 10.8 3.9 3 1 0 3 3 3 3 LIM domain Thermopsin PF05317.11 CDW56387.1 - 0.15 11.5 0.3 0.18 11.2 0.3 1.1 1 0 0 1 1 1 0 Thermopsin Metallophos PF00149.28 CDW56388.1 - 3.5e-37 128.9 0.1 4.4e-37 128.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Levi_coat PF01819.17 CDW56388.1 - 0.22 11.5 0.1 0.39 10.7 0.1 1.3 1 0 0 1 1 1 0 Levivirus coat protein bZIP_2 PF07716.15 CDW56389.1 - 3.6e-10 39.8 19.0 3.6e-10 39.8 19.0 3.3 4 1 0 4 4 4 1 Basic region leucine zipper Sas10_Utp3 PF04000.15 CDW56389.1 - 1.5e-06 28.7 4.7 2.6e-06 28.0 3.3 2.2 1 1 1 2 2 2 1 Sas10/Utp3/C1D family IL2 PF00715.17 CDW56389.1 - 0.0081 16.1 2.1 0.012 15.5 1.5 1.6 1 1 0 1 1 1 1 Interleukin 2 DASH_Hsk3 PF08227.11 CDW56389.1 - 0.0093 16.3 1.2 0.28 11.6 0.2 3.0 2 1 0 2 2 2 1 DASH complex subunit Hsk3 like bZIP_1 PF00170.21 CDW56389.1 - 0.027 14.6 14.2 0.027 14.6 14.2 2.7 4 0 0 4 4 4 0 bZIP transcription factor DUF2605 PF10792.9 CDW56389.1 - 1.1 9.2 6.2 1.5 8.8 1.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2605) Pkinase PF00069.25 CDW56390.1 - 5.7e-35 121.0 0.0 1.5e-34 119.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56390.1 - 4.3e-17 62.3 0.0 6.3e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW56390.1 - 0.0001 21.7 0.0 0.00018 21.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDW56390.1 - 0.0039 16.0 0.0 0.0057 15.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CDW56390.1 - 0.041 12.8 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Patched PF02460.18 CDW56391.1 - 4.7e-214 713.0 6.2 5.9e-214 712.7 6.2 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW56391.1 - 1.2e-37 129.2 7.0 1.2e-37 129.2 7.0 2.7 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CDW56392.1 - 3.7e-08 32.0 0.0 4.7e-08 31.6 0.0 1.1 1 0 0 1 1 1 1 Patched family Motile_Sperm PF00635.26 CDW56393.1 - 6.6e-14 51.7 0.0 7.7e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain zf-HYPF PF07503.12 CDW56393.1 - 0.049 13.4 0.0 0.27 11.1 0.0 2.1 3 0 0 3 3 3 0 HypF finger ASH PF15780.5 CDW56393.1 - 0.1 12.8 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TFIIB PF00382.19 CDW56394.1 - 2.1e-50 168.7 4.9 8.2e-25 86.6 0.3 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CDW56394.1 - 1.2e-10 40.7 0.9 2e-10 40.0 0.9 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 CDW56394.1 - 2.4e-09 37.0 0.1 4.6e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDW56394.1 - 0.00016 21.8 0.2 0.45 10.6 0.0 2.3 2 0 0 2 2 2 2 Cyclin, C-terminal domain RB_B PF01857.20 CDW56394.1 - 0.0016 18.4 0.1 0.0084 16.1 0.1 1.9 1 1 1 2 2 2 1 Retinoblastoma-associated protein B domain TFIIB_C_1 PF18542.1 CDW56394.1 - 0.015 15.3 0.4 0.1 12.6 0.2 2.2 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 Pyr_redox_2 PF07992.14 CDW56395.1 - 2.6e-44 151.6 0.0 3.5e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AIF_C PF14721.6 CDW56395.1 - 6.3e-23 81.6 0.1 4.7e-10 39.9 0.0 2.3 2 0 0 2 2 2 2 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox PF00070.27 CDW56395.1 - 1.3e-10 41.7 0.0 5.3e-10 39.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Deltameth_res PF16020.5 CDW56395.1 - 7.6e-09 35.3 0.1 2.9e-08 33.4 0.0 2.0 2 0 0 2 2 2 1 Deltamethrin resistance NAD_binding_9 PF13454.6 CDW56395.1 - 0.0022 18.0 0.1 0.53 10.3 0.0 3.3 2 1 1 3 3 3 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CDW56395.1 - 0.022 13.9 0.0 0.22 10.6 0.0 2.1 2 1 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CDW56395.1 - 0.03 14.6 1.1 7.7 6.8 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CDW56395.1 - 0.033 13.4 0.0 0.076 12.3 0.0 1.7 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDW56395.1 - 0.14 11.2 0.0 58 2.6 0.0 3.5 4 0 0 4 4 4 0 Lycopene cyclase protein Aa_trans PF01490.18 CDW56396.1 - 2.4e-51 174.7 34.3 6.2e-51 173.4 34.3 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF229 PF02995.17 CDW56397.1 - 1.4e-240 799.1 0.2 2.1e-120 402.7 0.0 2.8 4 0 0 4 4 4 2 Protein of unknown function (DUF229) Sulfatase PF00884.23 CDW56397.1 - 0.00022 20.7 0.0 0.68 9.3 0.0 2.5 2 0 0 2 2 2 2 Sulfatase LigT_PEase PF02834.16 CDW56397.1 - 0.00083 19.5 0.0 2.8 8.2 0.0 2.8 2 0 0 2 2 2 2 LigT like Phosphoesterase PP-binding PF00550.25 CDW56397.1 - 0.003 17.9 0.0 3.8 7.9 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AOC_like PF18678.1 CDW56397.1 - 0.049 13.2 0.6 8.8 5.9 0.1 2.4 2 0 0 2 2 2 0 Allene oxide cyclase barrel like domain SWIM PF04434.17 CDW56397.1 - 0.073 12.8 1.2 15 5.4 0.1 2.6 2 0 0 2 2 2 0 SWIM zinc finger Coagulin PF02035.15 CDW56397.1 - 0.16 11.9 0.7 61 3.4 0.0 3.5 4 0 0 4 4 4 0 Coagulin Phosphodiest PF01663.22 CDW56397.1 - 0.18 11.4 0.0 25 4.3 0.0 3.1 4 0 0 4 4 4 0 Type I phosphodiesterase / nucleotide pyrophosphatase B56 PF01603.20 CDW56399.1 - 1.2e-193 643.8 10.4 1.4e-193 643.5 10.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) HAD_2 PF13419.6 CDW56399.1 - 0.33 11.0 3.1 2.7 8.0 0.1 3.0 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase DUF349 PF03993.12 CDW56399.1 - 0.56 10.5 11.0 0.11 12.9 2.6 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) zf-C2H2 PF00096.26 CDW56400.1 - 2.6e-19 68.5 31.6 0.00037 20.8 1.5 6.5 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW56400.1 - 7.1e-13 48.2 38.5 0.001 19.7 0.8 6.9 7 0 0 7 7 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW56400.1 - 1.4e-07 31.6 10.1 0.096 13.0 1.0 4.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 CDW56400.1 - 3.7e-06 27.1 31.9 0.12 12.8 0.3 7.3 7 0 0 7 7 7 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 CDW56400.1 - 0.00058 19.8 22.1 0.0052 16.7 1.0 5.8 5 0 0 5 5 5 1 C2H2-type zinc finger FOXP-CC PF16159.5 CDW56400.1 - 0.0012 19.4 11.6 0.95 10.1 2.3 4.4 1 1 4 5 5 5 1 FOXP coiled-coil domain GcpE PF04551.14 CDW56400.1 - 0.0023 17.1 1.2 0.0026 16.9 1.2 1.2 1 0 0 1 1 1 1 GcpE protein zf-met PF12874.7 CDW56400.1 - 0.024 15.0 10.2 21 5.7 0.1 5.5 5 0 0 5 5 4 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 CDW56400.1 - 0.038 14.1 0.7 0.038 14.1 0.7 4.6 5 0 0 5 5 5 0 Zinc ribbon domain Cys_rich_CPXG PF14255.6 CDW56400.1 - 0.041 13.8 0.1 0.041 13.8 0.1 2.2 3 0 0 3 3 1 0 Cysteine-rich CPXCG zf-Nse PF11789.8 CDW56400.1 - 0.043 13.6 1.8 1.4 8.8 0.0 3.0 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C2H2_aberr PF17017.5 CDW56400.1 - 0.083 13.0 14.8 1 9.4 2.3 3.3 2 2 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_8 PF15909.5 CDW56400.1 - 0.19 12.0 16.7 0.88 9.9 0.5 3.6 1 1 2 3 3 3 0 C2H2-type zinc ribbon Sgf11 PF08209.11 CDW56400.1 - 0.21 11.2 0.4 0.21 11.2 0.4 4.3 5 0 0 5 5 4 0 Sgf11 (transcriptional regulation protein) DUF4729 PF15866.5 CDW56400.1 - 0.22 10.8 0.2 0.22 10.8 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4729) zf-ACC PF17848.1 CDW56400.1 - 0.23 11.6 0.0 0.23 11.6 0.0 3.7 4 0 0 4 4 3 0 Acetyl-coA carboxylase zinc finger domain zf_UBZ PF18439.1 CDW56400.1 - 0.55 9.9 0.1 0.55 9.9 0.1 4.8 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf_ZIC PF18366.1 CDW56400.1 - 0.57 10.3 10.1 0.75 10.0 0.0 4.6 3 1 2 5 5 5 0 Zic proteins zinc finger domain zinc_ribbon_15 PF17032.5 CDW56400.1 - 1 10.2 15.8 0.39 11.5 0.4 3.3 3 1 0 3 3 3 0 zinc-ribbon family zf-CCHC_3 PF13917.6 CDW56400.1 - 1.8 8.6 11.1 4.5 7.3 1.3 3.2 2 0 0 2 2 2 0 Zinc knuckle zf-3CxxC_2 PF17180.4 CDW56400.1 - 2.2 9.0 12.5 2.1 9.1 7.0 3.0 1 1 1 2 2 2 0 Zinc-binding domain IBR PF01485.21 CDW56400.1 - 2.3 8.5 22.6 0.79 10.0 0.7 3.8 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain DRY_EERY PF09750.9 CDW56401.1 - 9.9e-16 58.2 0.4 9.9e-16 58.2 0.4 1.8 2 1 0 2 2 2 1 Alternative splicing regulator HCMV_UL139 PF12507.8 CDW56401.1 - 0.05 14.0 1.4 4.3 7.7 0.4 2.2 2 0 0 2 2 2 0 Human Cytomegalovirus UL139 protein Josephin PF02099.17 CDW56402.1 - 5e-40 137.3 0.3 2.6e-39 134.9 0.3 2.1 1 1 0 1 1 1 1 Josephin BTB_2 PF02214.22 CDW56403.1 - 7.1e-24 84.0 0.0 1.3e-23 83.1 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Arrestin_N PF00339.29 CDW56404.1 - 2.5e-23 82.8 0.0 4.6e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CDW56404.1 - 2.9e-19 69.8 0.7 8.4e-11 42.5 0.2 2.9 2 2 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 CDW56404.1 - 0.00024 20.4 3.4 0.21 10.7 0.0 3.8 4 0 0 4 4 4 2 Rgp1 Abhydrolase_1 PF00561.20 CDW56405.1 - 7.6e-07 29.0 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW56405.1 - 0.00046 20.9 0.0 0.00074 20.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.22 CDW56405.1 - 0.0031 17.5 0.0 0.0052 16.8 0.0 1.3 1 0 0 1 1 1 1 Cutinase LIDHydrolase PF10230.9 CDW56405.1 - 0.0079 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 CDW56405.1 - 0.01 15.2 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CDW56405.1 - 0.015 15.2 0.1 0.034 14.0 0.1 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF1749 PF08538.10 CDW56405.1 - 0.029 13.5 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Say1_Mug180 PF10340.9 CDW56405.1 - 0.1 11.5 0.1 0.14 11.0 0.1 1.1 1 0 0 1 1 1 0 Steryl acetyl hydrolase COesterase PF00135.28 CDW56405.1 - 0.11 11.4 0.1 0.58 9.0 0.0 2.1 3 0 0 3 3 3 0 Carboxylesterase family RIC1 PF07064.13 CDW56406.1 - 3.6e-75 252.7 1.3 6e-75 251.9 1.3 1.4 1 0 0 1 1 1 1 RIC1 SRF-TF PF00319.18 CDW56407.1 - 2.1e-20 71.9 0.1 3.7e-20 71.1 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Dpy-30 PF05186.13 CDW56408.1 - 1.1e-17 63.4 0.1 1.6e-17 62.9 0.1 1.2 1 0 0 1 1 1 1 Dpy-30 motif RIIa PF02197.17 CDW56408.1 - 0.022 14.4 0.1 0.037 13.7 0.1 1.3 1 0 0 1 1 1 0 Regulatory subunit of type II PKA R-subunit JTB PF05439.12 CDW56409.1 - 4.7e-22 78.1 1.0 4.7e-22 78.1 1.0 1.8 2 0 0 2 2 2 1 Jumping translocation breakpoint protein (JTB) ERGIC_N PF13850.6 CDW56409.1 - 0.076 13.4 0.5 1 9.7 0.1 2.1 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) MLANA PF14991.6 CDW56409.1 - 0.12 12.6 0.2 0.67 10.3 0.0 2.0 1 1 1 2 2 2 0 Protein melan-A DUF229 PF02995.17 CDW56410.1 - 1.3e-57 195.5 9.1 1.5e-57 195.3 9.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Pkinase_Tyr PF07714.17 CDW56411.1 - 9.1e-66 221.8 0.1 1.6e-65 221.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW56411.1 - 3.7e-34 118.3 0.0 6.3e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 CDW56411.1 - 0.0014 18.2 0.1 0.0051 16.4 0.0 1.8 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 CDW56411.1 - 0.0088 15.4 0.2 0.017 14.5 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3535 PF12054.8 CDW56412.1 - 0.084 12.1 1.8 6.5 5.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3535) Rhomboid PF01694.22 CDW56414.1 - 1.5e-36 125.6 5.4 2.3e-36 125.1 5.4 1.3 1 0 0 1 1 1 1 Rhomboid family SAT PF16073.5 CDW56414.1 - 0.11 12.2 0.5 5.9 6.5 0.1 2.4 2 1 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis MtrE PF04206.12 CDW56414.1 - 0.15 11.4 4.7 1.7 7.9 0.9 2.4 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit E 7tm_1 PF00001.21 CDW56415.1 - 0.067 12.5 25.0 0.1 11.9 13.1 2.2 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) SNF5 PF04855.12 CDW56416.1 - 8.8e-48 163.2 0.1 1.6e-27 96.9 0.0 3.2 2 1 1 3 3 3 3 SNF5 / SMARCB1 / INI1 Sec3_C PF09763.9 CDW56417.1 - 9.6e-86 288.7 15.5 7.3e-85 285.8 15.5 2.0 1 1 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 CDW56417.1 - 3.1e-13 49.7 1.8 5.6e-13 48.8 0.3 2.3 2 0 0 2 2 2 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH DUF4897 PF16238.5 CDW56417.1 - 0.049 13.5 0.4 0.049 13.5 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4897) DASH_Duo1 PF08651.10 CDW56417.1 - 0.058 13.2 4.5 0.13 12.1 2.7 2.6 2 0 0 2 2 2 0 DASH complex subunit Duo1 GrpE PF01025.19 CDW56417.1 - 0.86 9.2 3.9 0.58 9.8 1.4 2.0 2 0 0 2 2 2 0 GrpE Fringe PF02434.16 CDW56418.1 - 4.6e-15 55.7 0.1 3.4e-14 52.9 0.1 1.9 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 CDW56418.1 - 0.00024 21.0 0.5 0.52 10.1 0.4 2.2 1 1 1 2 2 2 2 Galactosyltransferase EF-hand_7 PF13499.6 CDW56419.1 - 1.1e-11 45.0 0.3 3.6e-06 27.3 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW56419.1 - 2.8e-09 36.2 0.3 7.6e-05 22.3 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 CDW56419.1 - 2.4e-08 32.9 5.4 0.00014 21.1 0.1 4.0 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 CDW56419.1 - 9.4e-07 28.6 6.2 0.035 13.9 0.3 3.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 CDW56419.1 - 0.065 12.8 2.4 0.8 9.3 0.4 2.9 3 0 0 3 3 3 0 EF hand FAIM1 PF06905.13 CDW56420.1 - 9.5e-45 152.4 0.0 1.1e-44 152.2 0.0 1.0 1 0 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) zf_CopZ PF18423.1 CDW56420.1 - 0.0072 16.3 0.0 0.56 10.2 0.0 2.9 3 0 0 3 3 3 1 Zinc binding domain WD40 PF00400.32 CDW56421.1 - 1.3e-28 98.7 8.3 5.4e-08 33.4 0.8 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56421.1 - 1.1e-08 35.3 0.1 1.1 9.7 0.0 4.2 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain zf-HC5HC2H_2 PF13832.6 CDW56422.1 - 1.2e-16 60.8 7.6 1.2e-16 60.8 7.6 3.1 4 0 0 4 4 4 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CDW56422.1 - 1.5e-08 34.7 26.5 1.9e-08 34.4 8.6 4.1 3 1 2 5 5 5 3 PHD-like zinc-binding domain PHD_2 PF13831.6 CDW56422.1 - 3.5e-06 26.5 5.0 3.5e-06 26.5 5.0 3.3 3 1 0 3 3 3 1 PHD-finger PHD PF00628.29 CDW56422.1 - 1.4e-05 24.9 7.4 1.4e-05 24.9 7.4 3.4 3 0 0 3 3 3 2 PHD-finger Prok-RING_1 PF14446.6 CDW56422.1 - 0.00035 20.4 1.3 0.00035 20.4 1.3 3.9 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 XTBD PF11952.8 CDW56423.1 - 1.2e-18 66.6 0.1 2.8e-18 65.5 0.1 1.6 1 0 0 1 1 1 1 XRN-Two Binding Domain, XTBD S4 PF01479.25 CDW56423.1 - 0.085 12.6 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 S4 domain Nup54 PF13874.6 CDW56424.1 - 0.065 13.3 0.0 0.19 11.8 0.0 1.8 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Sec1 PF00995.23 CDW56425.1 - 6.6e-62 210.5 0.0 8.4e-52 177.2 0.0 2.2 1 1 1 2 2 2 2 Sec1 family Abhydrolase_1 PF00561.20 CDW56426.1 - 3.5e-10 40.0 0.0 2.3e-09 37.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW56426.1 - 8.1e-08 33.1 0.0 1.3e-07 32.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDW56426.1 - 2.5e-07 30.2 0.0 5.4e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF915 PF06028.11 CDW56426.1 - 0.0036 16.7 0.0 0.0052 16.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Cutinase PF01083.22 CDW56426.1 - 0.023 14.7 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Cutinase DUF3530 PF12048.8 CDW56426.1 - 0.23 10.9 0.0 0.34 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) zf-H2C2_2 PF13465.6 CDW56427.1 - 1e-24 85.8 32.1 3.1e-09 36.8 0.6 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 CDW56427.1 - 4.5e-17 61.5 46.7 4.3e-06 26.9 1.9 6.2 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW56427.1 - 7.1e-15 54.4 46.0 0.00064 20.3 2.1 6.3 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW56427.1 - 3e-06 27.4 25.4 0.0095 16.2 0.4 5.9 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW56427.1 - 0.0004 20.3 40.5 0.0012 18.8 2.1 6.4 6 1 0 6 6 6 3 C2H2-type zinc finger zf-met PF12874.7 CDW56427.1 - 0.00089 19.6 23.5 0.13 12.7 1.7 5.1 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 CDW56427.1 - 0.0013 19.4 19.6 0.13 13.0 0.8 3.3 1 1 2 3 3 3 3 zinc-ribbon family FYVE PF01363.21 CDW56427.1 - 0.0032 17.6 28.9 0.32 11.2 11.2 3.6 1 1 2 3 3 3 3 FYVE zinc finger Spp-24 PF07448.11 CDW56427.1 - 0.011 15.9 0.4 0.029 14.6 0.1 1.9 1 1 1 2 2 2 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain DUF2180 PF09947.9 CDW56427.1 - 0.014 15.4 2.5 4 7.5 0.0 2.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) zf-C2H2_2 PF12756.7 CDW56427.1 - 0.014 15.7 25.9 0.29 11.5 0.7 5.4 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 CDW56427.1 - 0.017 15.4 27.0 0.07 13.4 4.5 3.8 3 1 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 CDW56427.1 - 0.017 14.9 2.2 0.017 14.9 2.2 5.3 6 0 0 6 6 5 0 zinc-finger C2H2-type PyrI_C PF02748.15 CDW56427.1 - 0.022 14.6 19.3 0.65 9.9 0.2 5.5 5 1 1 6 6 6 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 CDW56427.1 - 0.034 14.2 32.4 2 8.5 2.7 6.1 1 1 3 5 5 5 0 BED zinc finger zf-C2HC_2 PF13913.6 CDW56427.1 - 0.069 13.1 21.9 0.77 9.7 1.3 4.9 5 0 0 5 5 5 0 zinc-finger of a C2HC-type Zn-ribbon_8 PF09723.10 CDW56427.1 - 0.14 12.3 24.3 2.4 8.3 2.0 5.3 2 1 3 5 5 5 0 Zinc ribbon domain DUF2256 PF10013.9 CDW56427.1 - 0.19 11.9 20.6 4.8 7.4 0.1 6.1 6 0 0 6 6 6 0 Uncharacterized protein conserved in bacteria (DUF2256) zf_UBZ PF18439.1 CDW56427.1 - 0.19 11.4 20.4 0.97 9.1 0.2 5.7 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 CDW56427.1 - 0.24 12.1 17.5 2.5 8.8 4.1 3.9 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-H2C2_5 PF13909.6 CDW56427.1 - 0.35 10.7 0.2 0.35 10.7 0.2 7.2 7 1 0 7 7 6 0 C2H2-type zinc-finger domain HNH_5 PF14279.6 CDW56427.1 - 0.43 10.5 16.5 5.9 6.8 0.1 5.3 5 1 0 5 5 5 0 HNH endonuclease zf-CHCC PF10276.9 CDW56427.1 - 6.6 6.9 13.3 15 5.8 0.1 4.0 4 0 0 4 4 4 0 Zinc-finger domain DUF629 PF04780.12 CDW56427.1 - 9.8 4.6 20.6 3.7 6.0 1.9 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF629) LssY_C PF14067.6 CDW56428.1 - 0.21 11.1 0.0 0.31 10.6 0.0 1.1 1 0 0 1 1 1 0 LssY C-terminus HTH_psq PF05225.16 CDW56429.1 - 7.8e-26 89.6 0.0 3.1e-13 49.2 0.0 2.7 2 0 0 2 2 2 2 helix-turn-helix, Psq domain UPF0175 PF03683.13 CDW56429.1 - 0.039 13.7 0.1 1.6 8.5 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0175) SRP72 PF08492.12 CDW56430.1 - 3.3e-18 65.8 12.8 3.3e-18 65.8 12.8 2.4 2 0 0 2 2 2 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 CDW56430.1 - 1.6e-17 63.6 5.2 2.1e-15 56.8 2.2 3.6 2 1 0 2 2 2 1 Putative TPR-like repeat TPR_2 PF07719.17 CDW56430.1 - 4.2e-08 32.7 15.4 0.24 11.6 0.0 6.4 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDW56430.1 - 1.4e-07 31.7 9.6 0.25 11.7 0.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDW56430.1 - 1.6e-07 31.5 3.4 0.21 12.5 0.0 5.7 7 0 0 7 7 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW56430.1 - 2.4e-07 31.2 16.7 0.33 11.5 0.0 6.3 4 2 1 6 6 6 3 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CDW56430.1 - 1.1e-05 25.0 2.6 0.01 15.5 0.1 3.7 4 0 0 4 4 3 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_15 PF13429.6 CDW56430.1 - 3.7e-05 23.1 0.8 0.0022 17.3 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW56430.1 - 0.0001 22.2 13.8 0.51 10.7 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDW56430.1 - 0.00013 22.5 0.1 0.48 11.1 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDW56430.1 - 0.00025 20.7 18.7 0.38 10.7 0.0 6.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 CDW56430.1 - 0.00079 19.7 4.4 0.077 13.3 0.0 3.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDW56430.1 - 0.0027 17.8 0.2 2.3 8.4 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW56430.1 - 0.0087 15.7 1.5 0.25 11.1 0.0 3.8 4 0 0 4 4 4 1 TPR repeat ANAPC3 PF12895.7 CDW56430.1 - 0.015 15.5 16.3 0.054 13.7 0.4 4.8 3 2 2 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 CDW56430.1 - 0.017 14.9 2.4 0.16 11.7 0.0 3.2 3 1 0 3 3 3 0 26S proteasome subunit RPN7 TPR_6 PF13174.6 CDW56430.1 - 0.064 13.9 11.3 12 6.8 0.5 5.4 5 1 0 5 5 4 0 Tetratricopeptide repeat PTS_IIA PF02255.16 CDW56430.1 - 0.081 13.0 2.6 0.23 11.5 0.6 2.6 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit HTH_32 PF13565.6 CDW56430.1 - 0.14 12.7 0.8 5.6 7.7 0.5 3.0 2 0 0 2 2 2 0 Homeodomain-like domain DUF2523 PF10734.9 CDW56430.1 - 0.15 12.7 0.1 0.32 11.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2523) TPR_7 PF13176.6 CDW56430.1 - 0.69 10.1 8.9 1.2 9.3 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 CDW56430.1 - 4.1 7.5 5.3 11 6.2 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW56430.1 - 7.6 6.7 10.8 9.9 6.3 0.0 4.4 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat DnaJ PF00226.31 CDW56431.1 - 5.5e-16 58.4 0.1 2.9e-15 56.1 0.1 1.9 1 1 0 1 1 1 1 DnaJ domain Dynein_light PF01221.18 CDW56433.1 - 1.9e-16 60.2 0.1 5e-16 58.8 0.1 1.8 1 0 0 1 1 1 1 Dynein light chain type 1 DUF2808 PF10989.8 CDW56433.1 - 0.0026 17.7 0.5 0.0063 16.5 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2808) FAM76 PF16046.5 CDW56433.1 - 0.084 12.2 4.9 0.15 11.4 4.9 1.3 1 0 0 1 1 1 0 FAM76 protein TRP_2 PF08344.11 CDW56434.1 - 1.2e-10 41.4 3.9 2.5e-10 40.4 3.9 1.6 1 0 0 1 1 1 1 Transient receptor ion channel II Ion_trans PF00520.31 CDW56434.1 - 8.3e-09 35.0 11.8 1.7e-08 34.0 11.8 1.5 1 0 0 1 1 1 1 Ion transport protein Ank_3 PF13606.6 CDW56434.1 - 1.1e-05 25.3 0.8 0.0034 17.7 0.2 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 CDW56434.1 - 2.7e-05 24.7 0.0 0.00018 22.1 0.0 2.5 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDW56434.1 - 0.00013 22.3 0.4 0.0013 19.1 0.5 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 CDW56434.1 - 0.0011 19.3 0.0 0.021 15.1 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW56434.1 - 0.074 13.7 0.0 0.73 10.5 0.0 2.5 1 1 1 3 3 3 0 Ankyrin repeats (many copies) 7tm_1 PF00001.21 CDW56436.1 - 5.9e-18 65.1 20.8 3.4e-17 62.6 20.8 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) O-antigen_lig PF13425.6 CDW56436.1 - 0.23 10.2 15.9 0.23 10.2 4.4 2.2 2 0 0 2 2 2 0 O-antigen ligase like membrane protein SIP1 PF04938.12 CDW56437.1 - 1e-27 97.3 0.0 1.2e-27 97.1 0.0 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Bystin PF05291.11 CDW56437.1 - 0.11 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 Bystin Motile_Sperm PF00635.26 CDW56438.1 - 6.3e-10 38.9 0.0 1.2e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Reprolysin_5 PF13688.6 CDW56439.1 - 2.4e-27 96.4 0.6 2.4e-27 96.4 0.6 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 CDW56439.1 - 4.7e-26 91.9 0.3 1.2e-25 90.6 0.3 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CDW56439.1 - 2.1e-18 67.0 0.1 3.9e-18 66.2 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 CDW56439.1 - 4.3e-09 37.0 28.6 4.3e-09 37.0 28.6 3.1 3 0 0 3 3 3 1 Disintegrin Reprolysin_4 PF13583.6 CDW56439.1 - 1.9e-06 27.7 2.2 1.2e-05 25.0 2.2 2.0 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 CDW56439.1 - 8.3e-05 22.6 0.0 8.3e-05 22.6 0.0 2.3 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 CDW56439.1 - 0.047 13.9 0.9 0.077 13.2 0.0 1.8 2 0 0 2 2 2 0 Reprolysin family propeptide RPM2 PF08579.11 CDW56439.1 - 0.16 12.4 0.3 0.35 11.3 0.3 1.5 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) LEM PF03020.15 CDW56440.1 - 6.9e-06 25.5 0.1 1.5e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 LEM domain Iso_dh PF00180.20 CDW56442.1 - 8.6e-67 225.7 0.1 5.6e-51 173.7 0.0 3.0 1 1 2 3 3 3 3 Isocitrate/isopropylmalate dehydrogenase Thioredoxin PF00085.20 CDW56443.1 - 5.5e-24 84.1 0.0 9.7e-24 83.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 CDW56443.1 - 1.4e-08 34.8 0.0 1.6e-05 24.9 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDW56443.1 - 0.00045 20.6 0.0 0.0015 19.0 0.0 1.9 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDW56443.1 - 0.0087 16.2 0.0 0.019 15.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 CDW56443.1 - 0.017 14.9 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin OST3_OST6 PF04756.13 CDW56443.1 - 0.048 13.0 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 CDW56443.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 AhpC/TSA family PRELI PF04707.14 CDW56444.1 - 6.6e-47 159.2 0.2 8.2e-47 158.9 0.2 1.1 1 0 0 1 1 1 1 PRELI-like family Metallophos PF00149.28 CDW56445.1 - 7e-12 46.3 0.4 8.3e-12 46.0 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDW56445.1 - 0.074 13.2 0.0 0.092 12.9 0.0 1.1 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain 7TM_GPCR_Srsx PF10320.9 CDW56447.1 - 2.3e-10 40.3 17.0 2.5e-10 40.2 17.0 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 CDW56447.1 - 9.3e-06 25.2 14.3 1.5e-05 24.5 14.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Auxin_inducible PF02519.14 CDW56449.1 - 0.023 14.8 0.0 0.027 14.6 0.0 1.2 1 0 0 1 1 1 0 Auxin responsive protein DUF4713 PF15831.5 CDW56450.1 - 0.77 10.2 8.2 1.8 9.0 8.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) YqzH PF14164.6 CDW56451.1 - 0.019 15.0 0.1 0.15 12.1 0.0 2.2 2 0 0 2 2 2 0 YqzH-like protein RRM_7 PF16367.5 CDW56452.1 - 2e-33 114.3 0.0 5.7e-33 112.9 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif CEBP_ZZ PF16366.5 CDW56452.1 - 1.6e-14 53.8 5.3 3.7e-14 52.7 5.3 1.6 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain CEBP1_N PF16368.5 CDW56452.1 - 2.8e-09 36.9 1.1 4.1e-09 36.4 1.1 1.2 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein 1 N-terminus RRM_1 PF00076.22 CDW56452.1 - 2.2e-08 33.8 0.0 0.0075 16.1 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UPF0172 PF03665.13 CDW56453.1 - 1.4e-41 142.6 1.6 5.7e-32 111.3 0.1 2.0 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0172) JAB PF01398.21 CDW56453.1 - 0.035 14.1 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DHHC PF01529.20 CDW56454.1 - 3.6e-38 130.7 13.5 3.6e-38 130.7 13.5 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase CNRIP1 PF15043.6 CDW56454.1 - 0.061 12.9 0.0 0.097 12.2 0.0 1.2 1 0 0 1 1 1 0 CB1 cannabinoid receptor-interacting protein 1 DUF3742 PF12553.8 CDW56454.1 - 0.21 11.7 0.7 1.4 9.0 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3742) ThrE PF06738.12 CDW56454.1 - 2.4 7.5 10.4 0.057 12.8 3.0 1.8 2 0 0 2 2 2 0 Putative threonine/serine exporter DUF2663 PF10864.8 CDW56454.1 - 3.2 8.2 4.9 7 7.1 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) Tyr_Deacylase PF02580.16 CDW56455.1 - 2.2e-49 167.7 0.0 2.4e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase MIB_HERC2 PF06701.13 CDW56457.1 - 4.2e-40 135.8 25.5 4.4e-25 87.7 5.0 3.5 4 0 0 4 4 4 2 Mib_herc2 Ank_2 PF12796.7 CDW56457.1 - 1.2e-27 96.3 7.9 6e-13 49.2 0.1 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW56457.1 - 5.6e-22 77.8 3.8 8.4e-10 39.0 0.2 4.7 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW56457.1 - 2e-18 66.2 5.0 2.6e-09 37.1 0.1 3.8 1 1 1 3 3 3 3 Ankyrin repeats (many copies) SH3_15 PF18346.1 CDW56457.1 - 6.2e-18 64.9 6.2 6.1e-14 52.1 0.1 3.1 3 0 0 3 3 3 2 Mind bomb SH3 repeat domain Ank PF00023.30 CDW56457.1 - 1.7e-12 47.2 13.1 0.012 16.0 0.1 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 CDW56457.1 - 1.2e-11 43.7 4.0 0.012 16.0 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat ZZ PF00569.17 CDW56457.1 - 0.00021 21.0 13.9 0.00049 19.8 13.9 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type zf-C3HC4_3 PF13920.6 CDW56458.1 - 2.7e-28 97.6 56.9 2.6e-09 36.8 16.3 3.6 3 0 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) Ank_2 PF12796.7 CDW56458.1 - 1.4e-19 70.5 1.6 6.5e-09 36.3 0.0 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW56458.1 - 1.9e-19 69.7 0.4 9.4e-07 29.3 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW56458.1 - 1.1e-17 63.9 1.1 1.7e-06 28.2 0.1 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CDW56458.1 - 6.9e-17 61.1 2.5 0.00033 20.9 0.1 5.2 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 CDW56458.1 - 3.4e-12 45.4 2.9 0.012 16.1 0.1 5.7 6 0 0 6 6 6 3 Ankyrin repeat zf-C3HC4_2 PF13923.6 CDW56458.1 - 2e-05 24.4 13.2 2e-05 24.4 13.2 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW56458.1 - 3e-05 23.8 57.8 0.057 13.3 13.2 4.4 3 1 1 4 4 4 3 Prokaryotic RING finger family 4 SAM_decarbox PF01536.16 CDW56459.1 - 1.1e-103 347.0 0.1 1.3e-103 346.8 0.1 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase zf-U1 PF06220.12 CDW56460.1 - 2.2e-05 24.1 2.9 3e-05 23.7 2.9 1.2 1 0 0 1 1 1 1 U1 zinc finger zf-DBF PF07535.12 CDW56460.1 - 0.019 15.1 1.6 0.031 14.4 1.6 1.3 1 0 0 1 1 1 0 DBF zinc finger LPD5 PF18799.1 CDW56460.1 - 0.076 13.4 0.0 0.081 13.3 0.0 1.0 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 5 zf-H2C2_2 PF13465.6 CDW56461.1 - 1e-15 57.3 7.3 2.1e-09 37.4 0.9 5.4 5 1 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 CDW56461.1 - 2.9e-12 46.3 20.9 2.1e-06 27.9 1.0 4.6 5 0 0 5 5 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW56461.1 - 7.5e-09 35.7 27.9 0.00043 20.9 2.0 4.6 5 0 0 5 5 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW56461.1 - 1.7e-06 28.1 4.6 0.032 14.5 0.3 3.8 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW56461.1 - 6.2e-05 23.2 5.0 0.74 10.3 0.5 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 CDW56461.1 - 0.00095 19.7 14.5 1.4 9.6 0.2 4.0 2 1 2 4 4 4 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 CDW56461.1 - 0.0013 19.0 5.4 0.0013 19.0 5.4 2.9 1 1 1 3 3 3 1 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 CDW56461.1 - 0.0018 18.4 3.3 0.022 14.9 0.1 2.5 2 0 0 2 2 2 1 Aberrant zinc-finger zf-Di19 PF05605.12 CDW56461.1 - 0.0055 17.0 2.5 0.0055 17.0 2.5 3.4 1 1 2 3 3 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 CDW56461.1 - 0.016 15.6 18.0 0.64 10.5 3.7 3.8 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_9 PF14369.6 CDW56461.1 - 0.69 10.2 0.1 0.69 10.2 0.1 3.5 4 1 0 4 4 3 0 zinc-ribbon zf_C2H2_ZHX PF18387.1 CDW56461.1 - 0.98 9.1 6.3 6.4 6.5 0.4 3.2 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain HypA PF01155.19 CDW56461.1 - 2.4 8.2 7.8 3.2 7.8 0.3 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA MRP-S34 PF16053.5 CDW56462.1 - 6.9e-34 116.3 0.4 8.7e-34 116.0 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 MBOAT PF03062.19 CDW56463.1 - 5.8e-10 39.0 10.8 5.8e-10 39.0 10.8 2.1 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF5360 PF17314.2 CDW56463.1 - 0.5 10.4 4.8 0.28 11.3 1.1 2.4 3 0 0 3 3 3 0 Family of unknown function (DUF5360) NUC153 PF08159.12 CDW56464.1 - 1e-15 57.2 10.0 2.6e-10 39.9 0.5 3.0 3 0 0 3 3 3 2 NUC153 domain tRNA-synt_1e PF01406.19 CDW56465.1 - 5.1e-123 410.2 0.3 8.4e-123 409.5 0.3 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain zf-C2H2_jaz PF12171.8 CDW56465.1 - 6.1e-08 32.8 2.1 6.1e-08 32.8 2.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding tRNA-synt_1g PF09334.11 CDW56465.1 - 6.2e-08 31.8 1.9 0.0045 15.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CDW56465.1 - 2.6e-05 22.7 0.0 0.0072 14.6 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Ead_Ea22 PF13935.6 CDW56465.1 - 4.6e-05 24.1 0.1 4.6e-05 24.1 0.1 2.6 2 0 0 2 2 2 1 Ead/Ea22-like protein tRNA-synt_1c PF00749.21 CDW56465.1 - 0.039 12.8 0.0 0.039 12.8 0.0 3.0 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain zf-C2H2_2 PF12756.7 CDW56465.1 - 0.094 13.1 0.7 0.31 11.4 0.7 1.9 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CDW56465.1 - 0.22 12.0 0.9 0.67 10.5 0.9 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW56465.1 - 4.8 8.3 5.6 2.8 9.0 0.2 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger LSM PF01423.22 CDW56466.1 - 5.7e-19 67.6 0.6 7.3e-19 67.2 0.6 1.2 1 0 0 1 1 1 1 LSM domain vATP-synt_E PF01991.18 CDW56466.1 - 0.046 13.1 0.3 0.055 12.9 0.3 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DHHC PF01529.20 CDW56467.1 - 2e-21 76.5 16.0 2e-21 76.5 16.0 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase Sad1_UNC PF07738.13 CDW56468.1 - 1.6e-29 102.6 0.0 4.1e-29 101.3 0.0 1.7 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal Rhomboid PF01694.22 CDW56468.1 - 6.8e-25 87.8 11.1 1.3e-24 86.9 11.1 1.4 1 0 0 1 1 1 1 Rhomboid family PIN_12 PF16289.5 CDW56468.1 - 0.042 14.3 0.3 0.11 12.9 0.3 1.7 1 0 0 1 1 1 0 PIN domain Cep57_MT_bd PF06657.13 CDW56468.1 - 0.46 11.0 2.8 1.2 9.6 2.8 1.7 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 SlyX PF04102.12 CDW56468.1 - 2.8 8.6 5.7 1 10.0 2.6 1.9 2 0 0 2 2 2 0 SlyX RL10P_insert PF17777.1 CDW56469.1 - 4.5e-23 81.0 0.0 7.6e-23 80.3 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 CDW56469.1 - 2e-18 66.4 0.0 3.6e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 RhoGEF PF00621.20 CDW56470.1 - 2.4e-33 115.9 2.1 3.3e-33 115.5 0.0 2.4 2 1 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.28 CDW56470.1 - 7.6e-09 35.0 0.0 1.7e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CDW56470.1 - 7.1e-05 22.6 0.0 0.00045 20.0 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 CDW56470.1 - 0.0017 18.6 0.1 0.0058 16.9 0.1 1.9 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_2 PF07653.17 CDW56470.1 - 0.016 14.9 0.0 0.036 13.7 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Atg14 PF10186.9 CDW56471.1 - 1.5e-13 50.6 4.8 1.8e-08 33.8 0.0 3.1 2 1 1 3 3 3 3 Vacuolar sorting 38 and autophagy-related subunit 14 APG6 PF04111.12 CDW56471.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Apg6 BARA domain RasGAP PF00616.19 CDW56472.1 - 7.1e-26 91.2 0.2 7.3e-25 87.9 0.0 2.5 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 CDW56472.1 - 5.8e-08 32.9 0.3 1.2e-07 31.9 0.0 1.7 2 0 0 2 2 2 1 C2 domain Rx_N PF18052.1 CDW56472.1 - 0.098 12.9 1.3 0.29 11.4 1.3 1.8 1 0 0 1 1 1 0 Rx N-terminal domain Exonuc_VII_L PF02601.15 CDW56472.1 - 2.5 7.6 5.5 4.9 6.6 5.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Histone_H2A_C PF16211.5 CDW56473.1 - 3.9e-19 68.1 0.1 7.9e-19 67.1 0.1 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW56473.1 - 4.9e-16 59.3 0.0 6.1e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW56473.1 - 8e-05 22.8 0.0 0.00011 22.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-MYND PF01753.18 CDW56474.1 - 0.00028 20.9 19.2 0.00028 20.9 19.2 2.5 2 0 0 2 2 2 1 MYND finger Homeobox_KN PF05920.11 CDW56475.1 - 3e-16 59.0 0.3 5.9e-16 58.1 0.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 CDW56475.1 - 2.7e-07 30.3 1.3 2.7e-07 30.3 1.3 2.1 2 0 0 2 2 2 1 Homeodomain MRP-S32 PF10210.9 CDW56475.1 - 0.065 13.8 0.4 0.15 12.6 0.4 1.7 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 Collagen PF01391.18 CDW56476.1 - 5.6e-25 86.9 101.6 3.6e-06 26.7 21.6 4.2 1 1 2 3 3 3 2 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW56476.1 - 1.2e-14 54.1 0.1 1.7e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain ATP-synt_D PF01813.17 CDW56477.1 - 3.3e-05 23.8 0.0 4.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase subunit D RIO1 PF01163.22 CDW56478.1 - 4.2e-59 199.3 1.0 9.5e-59 198.2 1.0 1.6 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 CDW56478.1 - 0.00046 19.8 0.4 0.14 11.7 0.0 2.8 2 1 0 2 2 2 2 PhoP regulatory network protein YrbL DUF2457 PF10446.9 CDW56479.1 - 0.063 12.4 1.5 0.084 12.0 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sugarporin_N PF11471.8 CDW56479.1 - 0.098 12.6 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension UPF0561 PF10573.9 CDW56479.1 - 1.9 8.7 7.8 21 5.3 7.8 2.2 1 1 0 1 1 1 0 Uncharacterised protein family UPF0561 RhoGAP PF00620.27 CDW56480.1 - 7.9e-30 103.7 0.0 1.1e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain p25-alpha PF05517.12 CDW56481.1 - 1.9e-49 167.8 3.2 2.3e-49 167.5 3.2 1.1 1 0 0 1 1 1 1 p25-alpha DUF1515 PF07439.11 CDW56481.1 - 0.31 11.1 2.1 0.34 11.0 0.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) DFP PF04127.15 CDW56482.1 - 1.1e-08 35.2 0.0 0.0029 17.4 0.0 2.7 3 0 0 3 3 3 2 DNA / pantothenate metabolism flavoprotein PRP3 PF08572.10 CDW56483.1 - 1.7e-69 234.0 6.0 1.7e-69 234.0 6.0 2.2 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 CDW56483.1 - 5.6e-42 143.3 3.3 1e-41 142.4 1.6 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1115) Phage_Mu_F PF04233.14 CDW56483.1 - 0.42 11.4 4.0 0.83 10.4 0.5 3.2 2 1 0 2 2 2 0 Phage Mu protein F like protein IPPT PF01715.17 CDW56483.1 - 1.2 8.9 7.0 0.3 10.9 1.3 2.5 2 1 0 2 2 2 0 IPP transferase PigN PF04987.14 CDW56484.1 - 5e-61 207.0 63.7 7.5e-61 206.4 63.7 1.3 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 CDW56484.1 - 0.00061 19.5 0.2 0.0015 18.2 0.2 1.5 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase PglZ PF08665.12 CDW56484.1 - 0.0099 16.0 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 1 PglZ domain Sulfatase PF00884.23 CDW56484.1 - 0.13 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Sulfatase Pro_isomerase PF00160.21 CDW56485.1 - 6.4e-39 133.8 0.1 9.6e-39 133.2 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MNNL PF07657.13 CDW56485.1 - 0.057 13.5 1.8 0.47 10.5 1.1 2.3 1 1 1 2 2 2 0 N terminus of Notch ligand Myosin_tail_1 PF01576.19 CDW56486.1 - 4e-78 263.4 184.0 4.8e-78 263.1 184.0 1.0 1 0 0 1 1 1 1 Myosin tail Filament PF00038.21 CDW56486.1 - 4.8e-08 32.9 168.3 0.00048 19.8 55.5 8.0 1 1 6 7 7 7 5 Intermediate filament protein CENP-F_leu_zip PF10473.9 CDW56486.1 - 0.0013 18.7 30.0 0.0013 18.7 30.0 9.3 1 1 7 8 8 8 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4200 PF13863.6 CDW56486.1 - 0.016 15.6 22.3 0.016 15.6 22.3 11.3 2 2 9 12 12 12 0 Domain of unknown function (DUF4200) GIT_CC PF16559.5 CDW56486.1 - 0.029 14.2 0.3 0.029 14.2 0.3 12.2 7 4 6 13 13 13 0 GIT coiled-coil Rho guanine nucleotide exchange factor TPR_MLP1_2 PF07926.12 CDW56486.1 - 0.066 13.3 196.7 0.054 13.5 23.7 9.6 2 2 7 9 9 9 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 CDW56486.1 - 0.19 10.6 177.1 0.02 13.8 32.4 7.4 1 1 5 7 7 7 0 Spc7 kinetochore protein DUF3584 PF12128.8 CDW56486.1 - 2.7 5.4 173.4 0.058 10.9 41.3 4.2 1 1 3 4 4 4 0 Protein of unknown function (DUF3584) Adap_comp_sub PF00928.21 CDW56487.1 - 1.2e-80 270.7 0.1 1.6e-80 270.3 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CDW56487.1 - 0.0002 21.3 0.2 0.00035 20.5 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 CDW56487.1 - 0.027 13.9 0.1 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain Fringe PF02434.16 CDW56487.1 - 0.097 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Fringe-like Kunitz_BPTI PF00014.23 CDW56488.1 - 1.2e-18 67.0 3.2 1.2e-18 67.0 3.2 2.6 2 1 1 3 3 3 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Sulfotransfer_1 PF00685.27 CDW56489.1 - 9.1e-26 90.9 0.0 1.1e-25 90.6 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDW56489.1 - 6.1e-11 43.1 0.0 4.5e-06 27.2 0.0 2.2 1 1 1 2 2 2 2 Sulfotransferase family Fun_ATP-synt_8 PF05933.13 CDW56489.1 - 0.044 14.0 0.3 0.044 14.0 0.3 2.0 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) Proteasome PF00227.26 CDW56492.1 - 2.9e-41 141.1 0.0 3.3e-41 140.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Tom37 PF10568.9 CDW56493.1 - 1.1e-20 74.2 0.0 1.6e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 CDW56493.1 - 5.5e-18 64.5 0.1 1e-17 63.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CDW56493.1 - 8.4e-16 58.5 0.0 1.4e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 CDW56493.1 - 0.004 17.1 0.0 0.0075 16.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TTR-52 PF01060.23 CDW56494.1 - 4.8e-13 49.6 0.1 2.2e-12 47.5 0.0 1.8 1 1 1 2 2 2 1 Transthyretin-like family Tub PF01167.18 CDW56495.1 - 1.1e-27 97.4 0.0 2.1e-27 96.4 0.0 1.5 1 1 0 1 1 1 1 Tub family RhoGEF PF00621.20 CDW56496.1 - 1e-66 224.7 14.4 2.9e-38 131.9 3.2 5.0 6 1 0 6 6 5 2 RhoGEF domain Spectrin PF00435.21 CDW56496.1 - 3.8e-25 88.4 50.2 9.3e-06 26.1 0.5 10.1 10 0 0 10 10 10 6 Spectrin repeat CRAL_TRIO_2 PF13716.6 CDW56496.1 - 5.9e-08 33.0 0.0 2.9e-07 30.7 0.0 2.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PH PF00169.29 CDW56496.1 - 2.9e-07 31.0 0.4 0.04 14.4 0.1 3.7 3 0 0 3 3 2 2 PH domain CRAL_TRIO PF00650.20 CDW56496.1 - 3.8e-06 26.7 1.1 0.00013 21.7 0.0 3.6 4 0 0 4 4 4 1 CRAL/TRIO domain IQ_SEC7_PH PF16453.5 CDW56496.1 - 0.00017 21.6 0.1 0.089 12.8 0.0 3.2 2 0 0 2 2 2 1 PH domain DUF4275 PF14101.6 CDW56496.1 - 0.011 15.8 2.2 0.14 12.3 0.9 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4275) GHMP_kinases_C PF08544.13 CDW56496.1 - 0.073 13.4 0.0 2 8.9 0.0 2.9 2 0 0 2 2 2 0 GHMP kinases C terminal NAPRTase_N PF17767.1 CDW56496.1 - 0.5 10.8 3.2 0.58 10.5 0.1 2.8 3 0 0 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Snf7 PF03357.21 CDW56496.1 - 0.57 9.8 6.5 4.9 6.7 6.5 2.8 1 0 0 1 1 1 0 Snf7 DUF2785 PF10978.8 CDW56496.1 - 2.9 7.6 7.7 0.48 10.2 0.2 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2785) PEPCK_GTP PF00821.18 CDW56497.1 - 9.3e-163 541.2 0.3 1.1e-162 540.9 0.3 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 CDW56497.1 - 4.6e-92 307.6 0.0 6.1e-92 307.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain DSPc PF00782.20 CDW56498.1 - 6.2e-33 113.4 0.1 9.9e-33 112.8 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PAC2 PF09754.9 CDW56498.1 - 2e-12 47.6 0.0 1.5e-11 44.8 0.0 2.2 1 1 0 1 1 1 1 PAC2 family Y_phosphatase PF00102.27 CDW56498.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 CDW56498.1 - 0.052 13.9 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 Rit1 DUSP-like domain SAE2 PF08573.10 CDW56499.1 - 9.5e-07 29.9 7.9 0.00019 22.5 0.8 2.6 1 1 1 2 2 2 2 DNA repair protein endonuclease SAE2/CtIP C-terminus VWA PF00092.28 CDW56500.1 - 6.2e-52 176.4 3.3 4.5e-27 95.4 0.0 2.0 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 CDW56500.1 - 1.4e-22 80.4 1.0 3e-10 40.7 0.0 2.6 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_3 PF13768.6 CDW56500.1 - 9.5e-11 41.9 0.2 0.00018 21.5 0.1 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 CDW56500.1 - 6.4e-07 29.0 0.0 0.0047 16.3 0.0 2.3 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 CDW56500.1 - 6.4e-05 23.2 1.0 0.066 13.3 0.0 2.2 2 0 0 2 2 2 2 vWA found in TerF C terminus CobT_C PF11775.8 CDW56500.1 - 0.0024 17.5 0.0 0.03 14.0 0.0 2.5 3 0 0 3 3 3 1 Cobalamin biosynthesis protein CobT VWA domain DrsE PF02635.15 CDW56500.1 - 0.003 17.9 0.1 2.7 8.4 0.0 2.5 2 0 0 2 2 2 2 DsrE/DsrF-like family Integrin_beta PF00362.18 CDW56500.1 - 0.0089 15.7 2.7 0.088 12.5 0.0 3.3 4 1 0 4 4 4 1 Integrin beta chain VWA domain RRM_1 PF00076.22 CDW56501.1 - 2.8e-07 30.2 0.0 5.2e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Alpha_adaptin_C PF02296.16 CDW56501.1 - 0.069 13.3 0.3 1 9.5 0.0 2.6 3 0 0 3 3 3 0 Alpha adaptin AP2, C-terminal domain Glycos_transf_2 PF00535.26 CDW56502.1 - 9.7e-27 93.8 0.0 1.8e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDW56502.1 - 5.2e-16 59.1 4.0 8.9e-16 58.3 4.0 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_2 PF10111.9 CDW56502.1 - 1e-05 25.2 0.0 1.7e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 CDW56502.1 - 1.3e-05 25.9 0.9 0.05 14.3 0.1 2.4 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_transf_7C PF02709.14 CDW56502.1 - 0.0016 18.0 0.1 0.0048 16.5 0.1 1.8 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 CDW56502.1 - 0.0049 16.8 0.0 0.027 14.4 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 GlcNAc PF11397.8 CDW56502.1 - 0.011 15.3 0.2 0.19 11.2 0.3 2.1 2 0 0 2 2 2 0 Glycosyltransferase (GlcNAc) PBC PF03792.13 CDW56503.1 - 2e-71 239.7 7.7 2.7e-69 232.7 7.7 2.3 1 1 0 1 1 1 1 PBC domain Homeodomain PF00046.29 CDW56503.1 - 6.6e-20 70.7 0.8 2.1e-19 69.1 0.8 1.9 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW56503.1 - 7e-16 57.9 0.0 2.2e-15 56.3 0.0 1.9 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 CDW56503.1 - 0.0014 18.4 0.0 0.0037 17.1 0.0 1.7 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_3 PF01381.22 CDW56503.1 - 0.012 15.7 0.0 0.046 13.8 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix KinB_sensor PF16767.5 CDW56503.1 - 0.014 15.8 5.5 0.64 10.5 0.0 3.5 3 1 1 4 4 4 0 Sensor domain of alginate biosynthesis sensor protein KinB HTH_26 PF13443.6 CDW56503.1 - 0.079 13.4 0.0 0.51 10.8 0.0 2.2 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain SYF2 PF08231.12 CDW56503.1 - 0.08 13.3 5.4 4.3 7.7 0.0 2.6 3 0 0 3 3 3 0 SYF2 splicing factor CENP-B_N PF04218.13 CDW56503.1 - 0.084 12.5 0.0 0.28 10.9 0.0 1.8 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Homez PF11569.8 CDW56503.1 - 0.091 12.2 0.3 0.77 9.3 0.0 2.4 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez HTH_31 PF13560.6 CDW56503.1 - 0.13 12.6 0.9 15 6.0 0.3 3.1 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 CDW56503.1 - 0.14 12.0 0.0 0.55 10.1 0.0 2.0 1 0 0 1 1 1 0 Homeodomain-like domain DUF3295 PF11702.8 CDW56503.1 - 0.17 11.2 3.7 0.17 11.2 2.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3295) FlxA PF14282.6 CDW56503.1 - 0.45 10.5 10.8 1.2 9.2 0.4 3.3 3 0 0 3 3 3 0 FlxA-like protein MADF_DNA_bdg PF10545.9 CDW56503.1 - 1.2 9.5 9.4 14 6.1 0.6 3.5 1 1 2 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like TMEM65 PF10507.9 CDW56503.1 - 2.2 8.3 3.9 8.1 6.4 0.0 3.3 3 2 0 4 4 4 0 Transmembrane protein 65 Ig_3 PF13927.6 CDW56504.1 - 1.7e-31 108.7 3.0 2.4e-11 44.1 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 CDW56504.1 - 1.4e-26 92.4 0.1 2.6e-11 43.4 0.0 3.8 3 0 0 3 3 3 3 Immunoglobulin I-set domain ig PF00047.25 CDW56504.1 - 9.1e-24 83.5 2.9 4.2e-09 36.4 0.0 3.7 4 0 0 4 4 4 3 Immunoglobulin domain Ig_2 PF13895.6 CDW56504.1 - 7.9e-21 74.2 1.5 2.1e-08 34.4 0.0 4.2 3 1 1 4 4 4 2 Immunoglobulin domain V-set PF07686.17 CDW56504.1 - 2.6e-14 53.3 3.4 1.8e-05 24.9 0.0 4.4 3 1 1 4 4 4 2 Immunoglobulin V-set domain fn3 PF00041.21 CDW56504.1 - 1.8e-06 28.2 0.5 5.6e-06 26.6 0.0 2.2 3 0 0 3 3 3 1 Fibronectin type III domain V-set_CD47 PF08204.11 CDW56504.1 - 9.4e-05 22.4 0.0 0.00044 20.2 0.0 2.1 1 0 0 1 1 1 1 CD47 immunoglobulin-like domain Ig_4 PF16680.5 CDW56504.1 - 0.00047 20.4 0.3 1.5 9.2 0.0 4.1 4 2 2 6 6 6 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 CDW56504.1 - 0.0018 18.3 0.7 0.8 9.8 0.0 2.8 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 CDW56504.1 - 0.018 15.6 0.2 0.88 10.2 0.0 2.6 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Ig_6 PF18452.1 CDW56504.1 - 0.024 14.2 0.0 3.5 7.3 0.0 3.0 2 0 0 2 2 2 0 Immunoglobulin domain BAR PF03114.18 CDW56505.1 - 1.2e-10 41.4 2.1 1.7e-10 41.0 2.1 1.1 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 CDW56505.1 - 5.4e-05 23.0 3.4 7e-05 22.6 3.4 1.1 1 0 0 1 1 1 1 BAR domain of APPL family HD_3 PF13023.6 CDW56505.1 - 0.014 15.3 0.2 0.025 14.5 0.2 1.4 1 0 0 1 1 1 0 HD domain YkyA PF10368.9 CDW56505.1 - 0.024 14.3 2.6 0.024 14.3 2.6 1.7 2 1 0 2 2 2 0 Putative cell-wall binding lipoprotein YliH PF10799.8 CDW56505.1 - 0.095 12.6 0.0 0.22 11.5 0.0 1.8 2 0 0 2 2 2 0 Biofilm formation protein (YliH/bssR) Fib_alpha PF08702.10 CDW56505.1 - 0.11 12.6 1.9 0.42 10.8 0.7 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 CDW56505.1 - 0.18 11.8 3.1 3 7.9 0.6 2.5 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain tRNA-synt_2 PF00152.20 CDW56506.1 - 1.1e-81 274.4 0.0 1.8e-81 273.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDW56506.1 - 1.4e-07 31.4 0.0 2.4e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDW56506.1 - 0.041 13.4 0.1 0.86 9.0 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) SRP9-21 PF05486.12 CDW56507.1 - 7.3e-11 42.3 0.3 4.6e-09 36.6 0.3 2.0 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) Phage_int_SAM_2 PF12834.7 CDW56507.1 - 0.023 15.3 0.1 0.033 14.9 0.1 1.3 1 1 0 1 1 1 0 Phage integrase, N-terminal PI3Ka PF00613.20 CDW56508.1 - 2.8e-25 88.8 0.3 9.7e-25 87.0 0.1 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 CDW56508.1 - 1.8e-16 60.7 0.5 8.9e-09 35.5 0.0 2.9 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase Tfb4 PF03850.14 CDW56508.1 - 0.019 14.5 0.0 0.089 12.3 0.0 2.1 2 0 0 2 2 2 0 Transcription factor Tfb4 Ipi1_N PF12333.8 CDW56508.1 - 0.11 13.1 0.5 3.1 8.5 0.0 3.2 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation SNF PF00209.18 CDW56509.1 - 7.9e-140 467.0 44.6 1e-139 466.7 44.6 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Pkinase PF00069.25 CDW56510.1 - 3e-26 92.4 0.0 3.6e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56510.1 - 8.6e-12 44.9 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW56510.1 - 0.00099 19.1 0.0 1.5 8.7 0.0 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW56510.1 - 0.012 14.4 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase ATP-gua_Ptrans PF00217.19 CDW56511.1 - 9.3e-82 273.6 0.0 1.2e-81 273.2 0.0 1.1 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 CDW56511.1 - 3.4e-28 97.9 0.0 5.8e-28 97.1 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain Sarcoglycan_1 PF04790.13 CDW56512.1 - 4.4e-55 186.8 0.1 5.1e-55 186.6 0.1 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein MFS_2 PF13347.6 CDW56513.1 - 1.2e-27 96.5 28.4 2.6e-27 95.5 28.4 1.5 1 1 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 CDW56513.1 - 1.1e-18 67.4 22.8 1.1e-17 64.0 23.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3382 PF11862.8 CDW56513.1 - 0.68 10.2 6.0 9.9 6.5 0.0 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF3382) RhoGAP PF00620.27 CDW56514.1 - 6.3e-21 74.8 0.0 1.3e-20 73.8 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PDZ PF00595.24 CDW56514.1 - 1e-08 35.4 0.1 2e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 PDZ domain C2 PF00168.30 CDW56514.1 - 0.00089 19.5 0.0 0.0018 18.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 CDW56514.1 - 0.008 16.0 0.2 0.021 14.7 0.2 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW56514.1 - 0.13 12.6 0.1 0.28 11.5 0.1 1.5 1 0 0 1 1 1 0 PDZ domain NMD3 PF04981.13 CDW56515.1 - 5.9e-64 215.8 7.8 9.4e-64 215.2 7.8 1.3 1 0 0 1 1 1 1 NMD3 family PNISR PF15996.5 CDW56516.1 - 3.8e-12 46.9 30.8 2.3e-07 31.3 2.5 3.3 1 1 2 3 3 3 2 Arginine/serine-rich protein PNISR Haspin_kinase PF12330.8 CDW56518.1 - 2.5e-41 141.8 0.0 3.3e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase PF00069.25 CDW56518.1 - 0.0017 17.7 0.0 0.0058 16.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56518.1 - 0.02 14.2 0.0 7.6 5.7 0.0 2.6 2 0 0 2 2 2 0 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW56519.1 - 0.0072 15.3 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Collagen PF01391.18 CDW56519.1 - 0.016 14.9 9.1 0.032 14.0 9.1 1.4 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Acetyltransf_1 PF00583.25 CDW56520.1 - 1.4e-11 44.6 0.1 1.8e-11 44.3 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CDW56520.1 - 1.6e-08 34.4 0.0 2.4e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 CDW56520.1 - 1.5e-07 31.4 0.0 1.7e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW56520.1 - 2.9e-07 30.8 0.0 5.2e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 CDW56521.1 - 2.3e-06 28.1 0.1 4.7e-05 23.9 0.1 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW56521.1 - 1.4e-05 25.2 1.3 0.0021 18.4 0.2 3.1 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW56521.1 - 7.4e-05 22.9 0.3 0.055 14.0 0.1 3.5 3 1 1 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 CDW56521.1 - 0.00017 22.0 0.1 0.017 15.7 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CDW56521.1 - 0.002 18.5 0.1 1.8 9.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Cauli_VI PF01693.16 CDW56521.1 - 0.0099 16.2 0.3 0.03 14.6 0.3 1.9 1 0 0 1 1 1 1 Caulimovirus viroplasmin GNT-I PF03071.15 CDW56522.1 - 7.5e-134 446.7 0.7 9.6e-132 439.8 0.7 2.0 1 1 0 1 1 1 1 GNT-I family Com_YlbF PF06133.11 CDW56522.1 - 0.17 12.5 0.2 0.38 11.4 0.2 1.5 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA Med23 PF11573.8 CDW56523.1 - 8e-208 693.1 15.0 9e-158 527.2 1.7 3.2 1 1 1 2 2 2 2 Mediator complex subunit 23 DUF3767 PF12597.8 CDW56525.1 - 0.065 13.1 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) DUF19 PF01579.18 CDW56528.1 - 1.8e-11 44.1 33.6 0.00013 21.8 7.0 3.4 3 0 0 3 3 3 3 Domain of unknown function (DUF19) CPG4 PF15481.6 CDW56528.1 - 7.8e-07 29.6 29.7 0.0077 16.8 2.8 5.4 4 1 1 5 5 5 3 Chondroitin proteoglycan 4 Albumin_I_a PF16720.5 CDW56528.1 - 0.1 12.5 0.2 9.6 6.2 0.0 3.3 2 1 1 3 3 3 0 Albumin I chain a TMEM154 PF15102.6 CDW56528.1 - 3 7.8 8.0 5.5 6.9 8.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family rve PF00665.26 CDW56531.1 - 0.0034 17.6 0.0 0.024 14.8 0.0 1.9 1 1 0 1 1 1 1 Integrase core domain Pro_isomerase PF00160.21 CDW56532.1 - 4.7e-49 166.7 0.0 7.6e-49 166.0 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 CDW56532.1 - 0.00048 19.6 0.0 0.0013 18.1 0.0 1.7 2 0 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.5 CDW56532.1 - 0.084 13.0 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein BrkDBD PF09607.10 CDW56533.1 - 3.8e-10 39.4 0.0 8.7e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 Brinker DNA-binding domain TnsD PF15978.5 CDW56533.1 - 0.00031 19.8 0.6 0.00034 19.7 0.6 1.0 1 0 0 1 1 1 1 Tn7-like transposition protein D HTH_Tnp_1 PF01527.20 CDW56533.1 - 0.0026 18.0 1.1 0.007 16.6 1.1 1.8 1 1 0 1 1 1 1 Transposase HTH_28 PF13518.6 CDW56533.1 - 0.0095 16.0 0.0 0.021 14.9 0.0 1.7 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc5 PF03221.16 CDW56533.1 - 0.016 15.2 0.4 0.041 13.9 0.2 1.7 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain HTH_29 PF13551.6 CDW56533.1 - 0.065 13.3 0.2 0.2 11.7 0.0 1.9 2 1 1 3 3 3 0 Winged helix-turn helix HTH_23 PF13384.6 CDW56533.1 - 0.096 12.5 0.0 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Helicase_C_2 PF13307.6 CDW56534.1 - 1.3e-53 181.7 0.1 8.2e-53 179.1 0.0 2.2 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 CDW56534.1 - 1.7e-45 154.8 1.7 4.6e-45 153.4 1.7 1.8 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 CDW56534.1 - 0.0029 17.4 0.1 0.31 10.8 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 CDW56534.1 - 0.016 14.7 0.0 4.2 6.8 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Hrs_helical PF12210.8 CDW56534.1 - 0.044 14.3 0.2 0.35 11.4 0.4 2.4 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate ResIII PF04851.15 CDW56534.1 - 0.049 13.6 1.5 2.8 7.9 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit SHQ1 PF04925.15 CDW56536.1 - 4.6e-21 75.2 0.0 5.8e-11 42.3 0.0 2.2 2 0 0 2 2 2 2 SHQ1 protein HSP20 PF00011.21 CDW56537.1 - 2.4e-25 88.6 0.3 3e-25 88.3 0.3 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW56537.1 - 1.2e-05 24.8 0.0 1.9e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Cupredoxin_1 PF13473.6 CDW56537.1 - 0.011 15.9 0.5 0.015 15.4 0.5 1.4 1 1 0 1 1 1 0 Cupredoxin-like domain HSP20 PF00011.21 CDW56538.1 - 8.7e-26 90.0 0.3 1.2e-25 89.6 0.3 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW56538.1 - 6.2e-05 22.5 0.0 9.8e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 CDW56539.1 - 3.3e-54 181.3 6.3 1.4e-23 82.9 0.2 4.2 3 1 0 3 3 3 3 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW56539.1 - 4.5e-07 29.3 0.0 0.00083 18.9 0.0 3.4 3 0 0 3 3 3 1 HSP20-like domain found in ArsA Cupredoxin_1 PF13473.6 CDW56539.1 - 0.004 17.3 2.9 2.3 8.4 0.1 3.2 3 0 0 3 3 3 2 Cupredoxin-like domain Big_6 PF17936.1 CDW56539.1 - 0.011 16.0 0.4 0.76 10.1 0.0 2.8 3 0 0 3 3 3 0 Bacterial Ig domain GH-E PF14410.6 CDW56539.1 - 0.016 15.6 0.1 8.2 6.9 0.0 2.6 2 0 0 2 2 2 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues YabP PF07873.11 CDW56539.1 - 0.021 14.6 0.0 0.85 9.5 0.0 2.4 2 0 0 2 2 2 0 YabP family Ribosomal_L9_N PF01281.19 CDW56539.1 - 0.071 12.7 0.0 19 4.9 0.0 2.7 2 0 0 2 2 2 0 Ribosomal protein L9, N-terminal domain DUF4307 PF14155.6 CDW56539.1 - 0.074 12.9 0.7 2.6 7.9 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) G6PD_bact PF10786.9 CDW56539.1 - 0.092 12.3 0.0 15 5.1 0.0 2.3 2 0 0 2 2 2 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) DUF1310 PF07006.11 CDW56539.1 - 0.12 12.4 2.2 49 3.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1310) DUF4845 PF16137.5 CDW56539.1 - 0.45 11.4 5.6 3.1 8.7 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4845) tRNA-synt_2b PF00587.25 CDW56540.1 - 1.8e-33 116.0 0.0 4.8e-33 114.6 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDW56540.1 - 2.1e-06 27.8 0.0 4.5e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain DZR PF12773.7 CDW56540.1 - 0.057 13.5 0.9 0.13 12.3 0.9 1.5 1 0 0 1 1 1 0 Double zinc ribbon TF_Zn_Ribbon PF08271.12 CDW56540.1 - 0.088 12.3 1.0 0.19 11.3 1.0 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 CDW56540.1 - 0.11 12.6 1.4 0.56 10.4 1.4 2.2 1 1 0 1 1 1 0 Zinc ribbon domain Ribosomal_L37e PF01907.19 CDW56540.1 - 0.18 12.0 0.6 0.59 10.3 0.6 1.8 1 0 0 1 1 1 0 Ribosomal protein L37e ArfGap PF01412.18 CDW56542.1 - 2.7e-30 104.8 0.9 4.7e-30 104.1 0.9 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ribosomal_L37ae PF01780.19 CDW56542.1 - 0.062 13.4 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family zf-B_box PF00643.24 CDW56542.1 - 0.11 12.6 0.2 0.19 11.9 0.2 1.3 1 0 0 1 1 1 0 B-box zinc finger zf-piccolo PF05715.13 CDW56542.1 - 0.17 12.1 1.4 0.4 10.9 1.4 1.5 1 0 0 1 1 1 0 Piccolo Zn-finger ABC_transp_aux PF09822.9 CDW56543.1 - 0.13 11.7 0.0 0.33 10.4 0.0 1.6 2 0 0 2 2 2 0 ABC-type uncharacterized transport system AAA_6 PF12774.7 CDW56544.1 - 1.7e-109 365.8 0.5 1.7e-107 359.2 0.5 2.8 1 1 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDW56544.1 - 1.7e-76 258.0 10.1 1.7e-76 258.0 10.1 5.7 5 0 0 5 5 5 2 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 CDW56544.1 - 6.1e-36 124.1 6.0 6.3e-36 124.0 0.0 4.0 6 0 0 6 6 4 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 CDW56544.1 - 5e-32 110.8 6.4 1.8e-19 69.8 0.0 4.8 4 1 1 5 5 4 2 ATP-binding dynein motor region Dynein_C PF18199.1 CDW56544.1 - 5.4e-28 98.1 1.8 6.3e-27 94.6 0.0 3.0 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CDW56544.1 - 4.8e-25 88.3 0.0 1.6e-24 86.6 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CDW56544.1 - 4.9e-25 87.9 0.0 3.1e-24 85.4 0.0 2.6 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain DHC_N1 PF08385.12 CDW56544.1 - 4.1e-23 81.9 10.5 4.1e-23 81.9 10.5 4.4 4 1 1 5 5 4 1 Dynein heavy chain, N-terminal region 1 AAA_5 PF07728.14 CDW56544.1 - 5.6e-23 81.5 0.1 6.9e-14 52.0 0.0 5.7 5 1 0 5 5 4 2 AAA domain (dynein-related subfamily) MT PF12777.7 CDW56544.1 - 4.4e-20 72.0 9.2 1.5e-19 70.3 9.2 1.9 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_16 PF13191.6 CDW56544.1 - 1.1e-06 29.2 5.4 0.049 14.0 0.0 6.6 6 1 1 7 7 4 1 AAA ATPase domain AAA_22 PF13401.6 CDW56544.1 - 1.5e-06 28.6 7.8 0.21 11.8 0.0 6.7 6 1 0 6 6 5 2 AAA domain AAA_7 PF12775.7 CDW56544.1 - 2.2e-06 27.3 0.5 0.071 12.6 0.1 4.5 5 0 0 5 5 4 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 CDW56544.1 - 2.4e-06 27.6 0.1 0.0019 18.1 0.1 3.6 3 0 0 3 3 2 1 RsgA GTPase AAA PF00004.29 CDW56544.1 - 5.8e-05 23.5 4.0 0.34 11.3 0.0 5.3 6 0 0 6 6 4 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDW56544.1 - 0.00021 21.7 0.0 0.77 10.2 0.0 4.1 4 0 0 4 4 3 1 RNA helicase AAA_18 PF13238.6 CDW56544.1 - 0.00045 20.8 0.0 1.8 9.1 0.0 3.8 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDW56544.1 - 0.00052 19.2 0.5 0.041 13.0 0.1 3.3 3 0 0 3 3 3 1 Type II/IV secretion system protein NACHT PF05729.12 CDW56544.1 - 0.0014 18.6 0.1 0.022 14.7 0.0 3.3 2 0 0 2 2 1 1 NACHT domain ATG16 PF08614.11 CDW56544.1 - 0.0016 18.7 6.3 0.0016 18.7 6.3 4.6 4 1 0 4 4 2 1 Autophagy protein 16 (ATG16) ABC_tran PF00005.27 CDW56544.1 - 0.0033 17.9 0.0 0.0033 17.9 0.0 5.1 7 0 0 7 7 4 1 ABC transporter CbiA PF01656.23 CDW56544.1 - 0.0058 16.7 0.0 1 9.5 0.0 3.0 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 CDW56544.1 - 0.014 15.2 1.0 7.2 6.3 0.0 3.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 CDW56544.1 - 0.014 15.1 0.1 0.53 10.1 0.0 3.3 4 0 0 4 4 3 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CDW56544.1 - 0.016 15.0 0.2 4.5 7.0 0.0 3.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDW56544.1 - 0.033 13.9 0.1 2 8.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 CDW56544.1 - 0.038 14.0 1.5 0.4 10.7 0.1 2.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 CDW56544.1 - 0.054 12.8 0.1 0.28 10.5 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Mating_N PF12731.7 CDW56544.1 - 0.095 12.8 0.5 2 8.6 0.5 3.5 1 0 0 1 1 1 0 Mating-type protein beta 1 AAA_19 PF13245.6 CDW56544.1 - 0.11 12.8 0.7 6.5 7.1 0.0 3.5 3 1 1 4 4 3 0 AAA domain Sigma54_activat PF00158.26 CDW56544.1 - 0.14 11.9 0.1 1 9.0 0.0 2.5 3 0 0 3 3 3 0 Sigma-54 interaction domain PhoH PF02562.16 CDW56544.1 - 0.16 11.4 0.5 1.6 8.2 0.0 2.8 3 0 0 3 3 3 0 PhoH-like protein PilJ PF13675.6 CDW56544.1 - 0.5 10.4 14.8 1.4 9.0 0.8 5.8 4 1 1 5 5 4 0 Type IV pili methyl-accepting chemotaxis transducer N-term PHTB1_C PF14728.6 CDW56545.1 - 1.9e-25 89.8 2.6 2.1e-25 89.6 2.6 1.0 1 0 0 1 1 1 1 PTHB1 C-terminus Prominin PF05478.11 CDW56545.1 - 0.0025 15.9 1.0 0.0028 15.7 1.0 1.1 1 0 0 1 1 1 1 Prominin DUF3445 PF11927.8 CDW56545.1 - 0.039 13.6 0.4 0.064 12.9 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3445) Adap_comp_sub PF00928.21 CDW56546.1 - 5.6e-48 163.6 0.0 8.5e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family CSD PF00313.22 CDW56546.1 - 0.072 12.9 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 'Cold-shock' DNA-binding domain DUF5319 PF17252.2 CDW56546.1 - 5.4 7.3 5.8 6.1 7.1 0.5 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5319) Bax1-I PF01027.20 CDW56547.1 - 4.2e-13 49.6 15.9 9.4e-13 48.5 15.8 1.5 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Oxidored_q3 PF00499.20 CDW56547.1 - 0.26 11.0 14.3 0.012 15.3 8.1 1.9 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Bax1-I PF01027.20 CDW56548.1 - 6e-05 23.0 2.2 6.5e-05 22.9 2.2 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Branch PF02485.21 CDW56549.1 - 3.9e-38 131.4 0.9 6e-38 130.7 0.9 1.3 1 0 0 1 1 1 1 Core-2/I-Branching enzyme Xylo_C PF12529.8 CDW56549.1 - 3.3e-05 23.6 0.0 6.1e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Xylosyltransferase C terminal Flu_C_NS1 PF03506.13 CDW56549.1 - 0.12 12.4 0.4 2.1 8.3 0.2 2.2 2 0 0 2 2 2 0 Influenza C non-structural protein (NS1) RasGEF PF00617.19 CDW56550.1 - 1.9e-46 158.5 0.2 4.7e-46 157.2 0.2 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CDW56550.1 - 9.8e-29 99.7 0.0 3.1e-28 98.1 0.0 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif RhoGEF PF00621.20 CDW56550.1 - 1.1e-13 51.8 1.4 4.7e-13 49.8 1.4 2.1 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 CDW56550.1 - 2.2e-07 31.3 0.0 6.8e-07 29.8 0.0 1.9 1 0 0 1 1 1 1 PH domain Histone PF00125.24 CDW56550.1 - 0.00046 20.6 0.0 0.0035 17.7 0.0 2.4 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 Ras PF00071.22 CDW56551.1 - 8e-49 165.3 0.0 1e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW56551.1 - 1.1e-20 74.0 0.0 2.7e-20 72.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW56551.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.5 1 1 0 1 1 1 0 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW56551.1 - 0.14 12.2 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase TniB PF05621.11 CDW56551.1 - 0.16 11.4 0.1 0.88 9.0 0.0 2.1 2 1 1 3 3 3 0 Bacterial TniB protein P5-ATPase PF12409.8 CDW56551.1 - 0.19 11.9 0.2 0.59 10.2 0.2 1.8 1 1 0 1 1 1 0 P5-type ATPase cation transporter Cys_knot PF00007.22 CDW56552.1 - 4.4e-14 52.6 14.9 3.3e-07 30.5 2.5 2.7 3 0 0 3 3 3 2 Cystine-knot domain DAN PF03045.15 CDW56552.1 - 0.0003 20.8 12.4 0.029 14.4 5.0 2.5 2 0 0 2 2 2 2 DAN domain Kinesin PF00225.23 CDW56553.1 - 5.4e-36 124.2 0.2 1.3e-35 122.9 0.2 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDW56553.1 - 4.6e-09 36.4 0.0 9.1e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding UIM PF02809.20 CDW56553.1 - 0.19 11.7 2.7 0.67 10.0 2.7 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif Homeodomain PF00046.29 CDW56554.1 - 1e-22 79.7 3.9 1.8e-22 78.9 3.9 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW56554.1 - 0.0066 16.3 0.1 0.0066 16.3 0.1 2.4 3 0 0 3 3 3 1 Homeobox KN domain NAD_binding_1 PF00175.21 CDW56554.1 - 0.043 14.5 0.1 0.074 13.7 0.1 1.3 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain GlgS PF08971.11 CDW56554.1 - 0.05 13.6 0.3 0.11 12.5 0.3 1.5 1 0 0 1 1 1 0 Glycogen synthesis protein AIG1 PF04548.16 CDW56554.1 - 0.075 12.4 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 AIG1 family FERM_M PF00373.18 CDW56555.1 - 4.7e-13 49.6 0.0 6.9e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 FERM central domain UL45 PF05473.12 CDW56557.1 - 0.22 11.2 0.1 0.51 9.9 0.0 1.6 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like YjbE PF11106.8 CDW56558.1 - 6.6 7.0 9.1 2.1 8.6 1.9 2.2 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE HTH_48 PF17906.1 CDW56559.1 - 0.0015 18.6 0.2 0.0081 16.3 0.2 2.1 1 1 0 1 1 1 1 HTH domain in Mos1 transposase HTH_10 PF04967.12 CDW56559.1 - 0.072 12.9 0.2 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 HTH DNA binding domain HTH_24 PF13412.6 CDW56559.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 CDW56559.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 MarR family Tmp39 PF10271.9 CDW56560.1 - 1.1e-87 294.8 26.9 1e-85 288.4 26.9 2.0 1 1 0 1 1 1 1 Putative transmembrane protein AAA PF00004.29 CDW56561.1 - 3.4e-42 144.0 0.0 5.6e-42 143.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CDW56561.1 - 5.3e-07 29.5 0.1 1.7e-06 27.9 0.1 1.9 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CDW56561.1 - 1.9e-06 27.9 0.3 1.8e-05 24.7 0.3 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 CDW56561.1 - 2.7e-06 27.1 0.1 5.4e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 CDW56561.1 - 1.7e-05 25.1 0.4 0.0034 17.7 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 CDW56561.1 - 6.1e-05 23.5 0.1 0.00074 19.9 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CDW56561.1 - 8e-05 22.4 0.0 0.00022 21.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDW56561.1 - 0.00017 21.7 0.0 0.00086 19.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDW56561.1 - 0.0011 19.2 0.1 0.0018 18.4 0.1 1.6 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDW56561.1 - 0.0011 18.4 0.1 0.0029 17.0 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDW56561.1 - 0.0018 18.0 0.1 0.2 11.4 0.0 2.5 2 1 0 2 2 2 1 Sigma-54 interaction domain DUF815 PF05673.13 CDW56561.1 - 0.0024 17.1 0.0 0.0038 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CDW56561.1 - 0.0031 17.3 0.0 0.0063 16.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 CDW56561.1 - 0.004 17.0 0.1 0.032 14.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDW56561.1 - 0.0044 16.8 0.2 0.014 15.2 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDW56561.1 - 0.0047 17.5 0.0 0.01 16.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDW56561.1 - 0.0061 16.2 0.0 0.0097 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 CDW56561.1 - 0.0081 15.4 0.1 0.02 14.1 0.1 1.6 1 1 1 2 2 2 1 TIP49 P-loop domain PhoH PF02562.16 CDW56561.1 - 0.011 15.2 0.3 0.021 14.3 0.3 1.6 1 1 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 CDW56561.1 - 0.015 15.6 0.2 0.04 14.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CDW56561.1 - 0.017 14.5 0.3 0.062 12.6 0.1 1.9 2 0 0 2 2 2 0 KaiC AAA_7 PF12775.7 CDW56561.1 - 0.021 14.3 0.1 0.045 13.3 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CDW56561.1 - 0.027 14.4 0.0 0.06 13.3 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_17 PF13207.6 CDW56561.1 - 0.032 14.6 0.1 0.085 13.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 CDW56561.1 - 0.042 13.9 0.1 0.077 13.0 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 CDW56561.1 - 0.044 14.2 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TniB PF05621.11 CDW56561.1 - 0.057 12.8 0.0 2.3 7.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein Parvo_NS1 PF01057.17 CDW56561.1 - 0.074 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 CDW56561.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDW56561.1 - 0.3 11.4 2.9 0.24 11.7 0.3 2.0 2 1 0 2 2 1 0 AAA domain AAA_30 PF13604.6 CDW56561.1 - 0.51 10.0 4.6 0.34 10.6 0.2 2.5 3 1 0 3 3 3 0 AAA domain LIM PF00412.22 CDW56562.1 - 4e-15 55.8 15.2 1.8e-12 47.3 9.3 2.2 2 0 0 2 2 2 2 LIM domain Cytochrome_CBB3 PF13442.6 CDW56562.1 - 0.00097 19.4 3.8 0.82 10.0 0.1 2.9 3 0 0 3 3 3 2 Cytochrome C oxidase, cbb3-type, subunit III Anti-TRAP PF15777.5 CDW56562.1 - 0.0067 16.4 14.5 0.025 14.5 0.5 3.5 3 1 1 4 4 3 2 Tryptophan RNA-binding attenuator protein inhibitory protein Zn-ribbon_8 PF09723.10 CDW56562.1 - 0.022 14.9 13.2 0.62 10.2 3.7 3.2 3 0 0 3 3 3 0 Zinc ribbon domain zf_UBZ PF18439.1 CDW56562.1 - 0.092 12.4 15.7 0.51 10.0 0.5 4.4 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger DUF1924 PF09086.11 CDW56562.1 - 0.093 13.1 5.5 1.6 9.2 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF1924) zf-ACC PF17848.1 CDW56562.1 - 0.11 12.6 0.8 0.11 12.6 0.8 2.7 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain Cytochrom_C PF00034.21 CDW56562.1 - 0.2 12.8 1.4 6.9 7.9 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c DZR PF12773.7 CDW56562.1 - 0.7 10.0 11.7 17 5.5 7.6 3.3 2 1 1 3 3 3 0 Double zinc ribbon zf-ribbon_3 PF13248.6 CDW56562.1 - 0.84 9.1 0.1 0.84 9.1 0.1 3.3 5 0 0 5 5 5 0 zinc-ribbon domain zf-Mss51 PF13824.6 CDW56562.1 - 1.1 9.5 6.2 0.45 10.6 2.1 2.2 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 PSCyt3 PF07627.11 CDW56562.1 - 1.5 9.2 6.4 7.7 6.9 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1588) HNH PF01844.23 CDW56562.1 - 1.5 9.0 8.9 12 6.2 0.4 3.7 3 1 1 4 4 4 0 HNH endonuclease zf-MYND PF01753.18 CDW56562.1 - 1.6 8.9 14.3 64 3.8 0.9 3.2 2 1 1 3 3 3 0 MYND finger Cytochrome_C7 PF14522.6 CDW56562.1 - 2.9 7.9 12.9 1.7e+02 2.3 13.1 2.6 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c DnaJ_CXXCXGXG PF00684.19 CDW56562.1 - 3.9 7.9 12.1 23 5.4 0.2 2.9 2 1 0 2 2 2 0 DnaJ central domain zf-B_box PF00643.24 CDW56562.1 - 8.6 6.6 17.4 16 5.8 0.1 3.6 2 1 1 3 3 3 0 B-box zinc finger Glycos_transf_2 PF00535.26 CDW56563.1 - 6.5e-38 130.2 0.0 1e-37 129.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDW56563.1 - 9.8e-24 84.0 0.4 1.9e-23 83.1 0.4 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 CDW56563.1 - 1.3e-08 35.0 0.0 2.7e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDW56563.1 - 6.4e-05 22.5 0.4 0.00035 20.2 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDW56563.1 - 0.002 17.6 0.0 0.0094 15.5 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 RicinB_lectin_2 PF14200.6 CDW56563.1 - 0.072 13.8 0.1 1.6 9.5 0.0 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Thioredoxin PF00085.20 CDW56564.1 - 6.1e-13 48.6 0.7 0.012 15.6 0.0 5.1 4 1 1 5 5 5 5 Thioredoxin Pkinase PF00069.25 CDW56565.1 - 4.3e-19 68.9 0.0 5.3e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56565.1 - 6.9e-09 35.4 0.0 9.8e-09 34.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF983 PF06170.12 CDW56566.1 - 4.1 7.9 8.4 8.3 6.9 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF983) EI24 PF07264.11 CDW56567.1 - 2.1e-18 67.2 26.6 3.5e-18 66.5 25.9 1.6 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF229 PF02995.17 CDW56568.1 - 1.3e-62 212.1 0.2 1.6e-62 211.7 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DEC-1_N PF04625.13 CDW56569.1 - 0.63 9.0 5.2 0.74 8.8 5.2 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ndc1_Nup PF09531.10 CDW56570.1 - 0.91 8.1 4.7 0.99 8.0 4.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pneumo_att_G PF05539.11 CDW56570.1 - 2.2 7.8 19.7 2.9 7.4 19.7 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G TFIIF_alpha PF05793.12 CDW56570.1 - 2.7 6.5 11.8 3.3 6.2 11.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SMYLE_N PF18615.1 CDW56570.1 - 3.1 7.3 5.6 3.9 6.9 5.6 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Macoilin PF09726.9 CDW56570.1 - 6.3 5.2 8.2 7.6 5.0 8.2 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 CDW56570.1 - 6.8 5.8 21.3 9 5.4 21.3 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Pkinase_Tyr PF07714.17 CDW56571.1 - 8.4e-92 307.1 0.0 1.1e-91 306.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW56571.1 - 2.3e-35 122.2 0.0 2.9e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DHHC PF01529.20 CDW56572.1 - 3.7e-30 104.7 16.1 3.7e-30 104.7 16.1 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Herpes_UL49_5 PF05702.11 CDW56572.1 - 3.8 7.7 9.7 0.39 10.8 1.2 3.0 3 0 0 3 3 3 0 Herpesvirus UL49.5 envelope/tegument protein DUF805 PF05656.14 CDW56572.1 - 6.9 7.1 6.6 1 9.8 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF805) 4HBT_3 PF13622.6 CDW56573.1 - 2.3e-55 188.5 0.0 2.9e-55 188.2 0.0 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CDW56573.1 - 2.1e-31 108.5 0.0 4.4e-22 78.3 0.0 3.2 2 1 0 2 2 2 2 Acyl-CoA thioesterase Acylphosphatase PF00708.18 CDW56574.1 - 3.8e-24 84.9 0.1 4.5e-24 84.7 0.1 1.1 1 0 0 1 1 1 1 Acylphosphatase DUF2871 PF11070.8 CDW56574.1 - 0.056 13.7 0.0 0.085 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) UPF0176_N PF17773.1 CDW56574.1 - 0.12 12.8 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 UPF0176 acylphosphatase like domain CSN8_PSD8_EIF3K PF10075.9 CDW56575.1 - 1.6e-18 67.0 0.0 2.3e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Ank_4 PF13637.6 CDW56576.1 - 3.8e-06 27.3 0.0 0.0038 17.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW56576.1 - 4.2e-05 23.7 0.0 0.00012 22.3 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Glyco_hydro_20b PF02838.15 CDW56576.1 - 0.00013 22.8 0.0 0.00025 21.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Ank_2 PF12796.7 CDW56576.1 - 0.00093 19.7 0.0 0.0025 18.4 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW56576.1 - 0.0013 19.0 0.0 0.0078 16.6 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 CDW56576.1 - 0.0038 17.6 0.0 0.011 16.1 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Glycohydro_20b2 PF14845.6 CDW56576.1 - 0.048 14.3 0.1 5.1 7.8 0.1 2.6 3 0 0 3 3 3 0 beta-acetyl hexosaminidase like DUF4512 PF14975.6 CDW56577.1 - 0.0023 18.7 7.5 0.0035 18.1 7.5 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4512) zf-C2H2 PF00096.26 CDW56580.1 - 2.4e-11 43.4 12.5 4.3e-06 26.9 5.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW56580.1 - 2.2e-07 31.0 4.1 2.2e-07 31.0 4.1 2.7 3 1 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW56580.1 - 0.00025 21.6 18.3 0.0045 17.7 4.3 3.1 4 0 0 4 4 4 2 C2H2-type zinc finger FOXP-CC PF16159.5 CDW56580.1 - 0.004 17.8 1.0 0.004 17.8 1.0 2.6 1 1 1 3 3 3 1 FOXP coiled-coil domain DUF3850 PF12961.7 CDW56580.1 - 0.034 14.2 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3850) zf-met PF12874.7 CDW56580.1 - 0.1 13.0 0.6 0.1 13.0 0.6 2.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CDW56580.1 - 1.2 9.3 6.3 0.43 10.6 2.2 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CDW56580.1 - 7 6.5 11.5 0.62 9.9 3.0 3.0 4 0 0 4 4 4 0 zinc-finger C2H2-type Pkinase PF00069.25 CDW56581.1 - 7.5e-27 94.3 0.0 1.2e-26 93.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56581.1 - 4.2e-17 62.3 0.0 6e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW56581.1 - 1.1e-09 37.6 0.0 1.7e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW56581.1 - 6e-06 26.3 0.0 0.0013 18.7 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDW56581.1 - 0.012 15.0 0.1 0.017 14.5 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1108 PF06531.11 CDW56581.1 - 0.11 12.8 0.2 5.8 7.3 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1108) zf-nanos PF05741.13 CDW56581.1 - 0.15 12.3 0.2 0.29 11.4 0.2 1.4 1 0 0 1 1 1 0 Nanos RNA binding domain Acetyltransf_1 PF00583.25 CDW56582.1 - 6.2e-07 29.7 0.0 8.6e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDW56582.1 - 2e-05 24.9 0.0 4.2e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDW56582.1 - 6.9e-05 22.8 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW56582.1 - 0.0025 17.8 0.0 0.0063 16.5 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CDW56582.1 - 0.0045 17.1 0.0 0.0079 16.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDW56582.1 - 0.0073 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Ribosomal_S7 PF00177.21 CDW56583.1 - 2.5e-34 118.1 0.3 1.6e-29 102.5 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein S7p/S5e E1-E2_ATPase PF00122.20 CDW56585.1 - 1.9e-51 174.2 0.8 1.9e-51 174.2 0.8 3.2 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CDW56585.1 - 4e-39 134.2 9.1 4e-39 134.2 9.1 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CDW56585.1 - 1.5e-18 66.7 0.0 1.1e-17 63.8 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CDW56585.1 - 5.7e-16 58.0 0.1 3.1e-15 55.6 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 CDW56585.1 - 4.7e-14 53.2 3.2 1.4e-08 35.3 0.5 3.8 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDW56585.1 - 0.038 13.7 0.5 0.54 9.9 0.5 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF3784 PF12650.7 CDW56585.1 - 1.2 9.4 11.8 4 7.7 0.1 4.6 4 1 0 4 4 4 0 Domain of unknown function (DUF3784) Pkinase PF00069.25 CDW56586.1 - 4.8e-24 85.1 0.0 9.9e-24 84.1 0.0 1.5 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56586.1 - 1.7e-08 34.1 0.0 2.1e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW56586.1 - 1.2e-06 28.7 0.0 0.016 15.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDW56586.1 - 0.13 11.7 0.3 0.33 10.3 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DnaJ_C PF01556.18 CDW56588.1 - 1.1e-33 116.4 0.0 2e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CDW56588.1 - 4.1e-25 87.7 1.8 6.2e-25 87.1 1.8 1.3 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.25 CDW56590.1 - 1.1e-24 87.2 0.1 1.4e-24 86.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56590.1 - 4e-10 39.4 0.1 5.1e-10 39.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW56590.1 - 0.00024 20.5 0.0 0.00042 19.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW56590.1 - 0.00029 19.8 0.0 0.00038 19.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 CDW56590.1 - 0.00056 19.0 0.7 0.0017 17.4 0.1 1.8 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase ART PF01129.18 CDW56590.1 - 0.12 11.6 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase CHGN PF05679.16 CDW56591.1 - 1.1e-137 460.1 0.2 1.4e-137 459.6 0.2 1.2 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 CDW56591.1 - 6.2e-17 61.9 0.0 1.1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Fringe-like Glyco_transf_7C PF02709.14 CDW56591.1 - 2.9e-11 42.9 0.3 2.9e-11 42.9 0.3 1.8 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDW56591.1 - 8.1e-05 22.2 0.5 0.09 12.2 0.0 2.8 3 0 0 3 3 3 2 Glycosyltransferase like family 2 Galactosyl_T PF01762.21 CDW56591.1 - 0.0036 17.2 0.0 0.25 11.1 0.0 2.7 2 1 0 2 2 2 1 Galactosyltransferase Glycos_transf_2 PF00535.26 CDW56591.1 - 0.008 16.0 0.0 3.4 7.4 0.0 2.9 3 0 0 3 3 3 2 Glycosyl transferase family 2 CactinC_cactus PF09732.9 CDW56592.1 - 1.2e-52 177.1 6.5 2.1e-52 176.3 6.5 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 CDW56592.1 - 7.8e-44 149.8 2.1 7.8e-44 149.8 2.1 2.2 2 0 0 2 2 2 1 Conserved mid region of cactin CCSMST1 PF15013.6 CDW56593.1 - 2.1e-09 37.4 0.0 3.5e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 CCSMST1 family ADH_zinc_N PF00107.26 CDW56594.1 - 8.8e-17 61.3 0.1 1.6e-16 60.5 0.0 1.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CDW56594.1 - 0.014 14.9 0.4 0.02 14.3 0.4 1.3 1 1 0 1 1 1 0 short chain dehydrogenase AlaDh_PNT_C PF01262.21 CDW56594.1 - 0.018 14.3 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CDW56594.1 - 0.033 15.2 0.0 0.078 14.0 0.0 1.6 1 1 1 2 2 2 0 Zinc-binding dehydrogenase CDC37_C PF08564.10 CDW56594.1 - 0.046 13.8 0.0 0.062 13.4 0.0 1.2 1 0 0 1 1 1 0 Cdc37 C terminal domain MAF_flag10 PF01973.18 CDW56594.1 - 0.06 13.0 0.2 0.11 12.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF115 Patched PF02460.18 CDW56596.1 - 5.4e-66 223.3 14.1 7.9e-41 140.0 0.0 2.0 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 CDW56596.1 - 9.1e-33 113.3 4.0 9.1e-33 113.3 4.0 2.5 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation FUSC-like PF12805.7 CDW56596.1 - 9.4 5.2 6.3 19 4.2 6.3 1.4 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS MULE PF10551.9 CDW56597.1 - 5e-05 23.6 0.1 0.00014 22.2 0.1 1.7 1 1 1 2 2 2 2 MULE transposase domain ATP_synt_H PF05493.13 CDW56598.1 - 1.5e-19 70.2 3.4 2.1e-19 69.7 3.4 1.2 1 0 0 1 1 1 1 ATP synthase subunit H Xan_ur_permease PF00860.20 CDW56598.1 - 0.022 13.5 1.5 0.025 13.3 1.5 1.0 1 0 0 1 1 1 0 Permease family ERAP1_C PF11838.8 CDW56599.1 - 1.7e-34 119.8 0.0 2.6e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CDW56599.1 - 3.9e-30 105.0 0.0 6e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CDW56599.1 - 1.1e-25 90.9 0.0 2.4e-25 89.8 0.0 1.5 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain ODC_AZ PF02100.17 CDW56601.1 - 3.3e-10 39.9 0.0 4.8e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Tyrosinase PF00264.20 CDW56602.1 - 3.3e-36 125.6 3.9 3.5e-35 122.3 0.7 2.8 2 1 0 2 2 2 1 Common central domain of tyrosinase MMS1_N PF10433.9 CDW56603.1 - 4.4e-62 210.3 0.0 6.8e-62 209.7 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CDW56603.1 - 3e-61 207.5 0.0 7.6e-59 199.6 0.0 3.5 4 0 0 4 4 4 1 CPSF A subunit region DUF3741 PF12552.8 CDW56603.1 - 0.091 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3741) Nucleos_tra2_C PF07662.13 CDW56604.1 - 2.7e-27 96.0 12.5 9.9e-27 94.1 0.7 2.7 2 1 1 3 3 3 2 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CDW56604.1 - 4e-15 56.2 0.7 4e-15 56.2 0.7 4.2 5 0 0 5 5 5 1 Na+ dependent nucleoside transporter N-terminus DUF3040 PF11239.8 CDW56605.1 - 0.0014 18.9 0.2 0.0029 17.8 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3040) RIC3 PF15361.6 CDW56605.1 - 0.025 15.0 0.0 0.035 14.5 0.0 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF2207 PF09972.9 CDW56605.1 - 0.14 10.9 0.1 0.2 10.4 0.0 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4229 PF14012.6 CDW56605.1 - 0.48 10.6 4.5 0.87 9.7 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) Pkinase_Tyr PF07714.17 CDW56606.1 - 3.8e-67 226.3 0.0 5e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW56606.1 - 2.6e-39 135.2 0.0 3.8e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW56606.1 - 1.3e-10 41.2 0.0 2.8e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 CDW56606.1 - 0.0052 16.7 0.0 2.2 8.1 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 CDW56606.1 - 0.051 12.9 0.1 0.096 12.0 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YebF PF13995.6 CDW56606.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 YebF-like protein Pro_isomerase PF00160.21 CDW56607.1 - 3.4e-45 154.1 0.0 4.1e-45 153.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD FKBP_C PF00254.28 CDW56608.1 - 5.3e-34 116.4 0.0 6e-34 116.2 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Staph_haemo PF05480.11 CDW56609.1 - 0.079 12.7 0.1 1.2 9.0 0.0 2.6 3 0 0 3 3 3 0 Staphylococcus haemolytic protein Integrin_alpha2 PF08441.12 CDW56610.1 - 5.9e-65 220.0 0.0 1.2e-63 215.7 0.0 2.0 1 1 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 CDW56610.1 - 7.3e-17 61.2 28.6 1.8e-10 40.8 7.0 4.9 4 0 0 4 4 4 3 FG-GAP repeat VCBS PF13517.6 CDW56610.1 - 3e-05 24.5 9.6 0.046 14.3 2.7 3.9 1 1 2 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 CDW56610.1 - 2 8.6 4.8 5.5 7.2 4.8 1.7 1 0 0 1 1 1 0 Integrin alpha cytoplasmic region TCTP PF00838.17 CDW56611.1 - 2e-45 155.1 2.1 2.2e-45 155.0 2.1 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Flp1_like PF16982.5 CDW56611.1 - 0.0055 16.1 0.3 1.6 8.2 0.0 2.6 2 0 0 2 2 2 2 Putative Flagellin, Flp1-like, domain DUF327 PF03885.13 CDW56611.1 - 0.0082 16.1 3.6 0.84 9.6 0.4 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF327) SRI PF08236.11 CDW56611.1 - 0.53 10.5 4.6 0.62 10.3 2.2 2.2 2 1 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain Filamin PF00630.19 CDW56612.1 - 8.6e-169 550.1 18.3 8e-13 49.1 0.0 19.3 17 2 2 19 19 19 19 Filamin/ABP280 repeat DUF5060 PF16586.5 CDW56612.1 - 1.8e-10 41.0 0.0 6.3 7.3 0.0 10.9 13 0 0 13 13 13 1 Domain of unknown function (DUF5060) Big_3_5 PF16640.5 CDW56612.1 - 3.5e-10 39.9 14.4 0.022 15.0 0.1 11.5 14 1 0 14 14 14 1 Bacterial Ig-like domain (group 3) Invasin_D3 PF09134.10 CDW56612.1 - 6.5e-08 32.8 8.8 0.044 14.1 0.0 9.3 10 1 0 10 10 9 2 Invasin, domain 3 YtkA PF13115.6 CDW56612.1 - 0.00013 22.5 0.3 91 3.8 0.0 8.3 10 0 0 10 10 9 0 YtkA-like FixH PF05751.11 CDW56612.1 - 0.00023 21.2 0.0 1.7 8.6 0.0 4.5 4 0 0 4 4 4 1 FixH CopC PF04234.12 CDW56612.1 - 0.00091 20.2 6.6 39 5.4 0.3 7.8 9 0 0 9 9 7 0 CopC domain DUF3244 PF11589.8 CDW56612.1 - 0.0013 18.8 0.0 0.88 9.7 0.0 5.3 4 1 1 5 5 5 1 Domain of unknown function (DUF3244) FlgD_ig PF13860.6 CDW56612.1 - 0.0015 18.3 2.7 6.2 6.8 0.0 5.5 4 0 0 4 4 4 1 FlgD Ig-like domain Big_6 PF17936.1 CDW56612.1 - 0.0069 16.6 10.4 8 6.8 0.0 8.4 9 1 2 11 11 11 1 Bacterial Ig domain DUF3416 PF11896.8 CDW56612.1 - 0.017 15.5 0.0 20 5.4 0.0 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF3416) Big_3 PF07523.12 CDW56612.1 - 4.8 7.6 8.3 2.5e+02 2.1 0.1 6.4 7 0 0 7 7 6 0 Bacterial Ig-like domain (group 3) Fis1_TPR_C PF14853.6 CDW56613.1 - 3e-20 72.0 0.5 4.5e-20 71.5 0.5 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 CDW56613.1 - 0.0062 16.6 0.3 0.012 15.6 0.3 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 CDW56613.1 - 0.035 13.8 0.0 0.077 12.7 0.0 1.6 1 0 0 1 1 1 0 Fis1 N-terminal tetratricopeptide repeat COPI_C PF06957.11 CDW56613.1 - 0.14 10.9 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus ETC_C1_NDUFA4 PF04800.12 CDW56614.1 - 2.6e-23 82.1 0.4 4.8e-23 81.2 0.4 1.4 1 1 0 1 1 1 1 ETC complex I subunit conserved region Na_H_Exchanger PF00999.21 CDW56615.1 - 3.2e-71 240.2 39.1 2.5e-69 233.9 39.1 2.8 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family DSPc PF00782.20 CDW56615.1 - 2.5e-18 66.2 0.0 6.7e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 CDW56615.1 - 0.11 12.8 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Rit1 DUSP-like domain Helicase_C PF00271.31 CDW56616.1 - 1.6e-30 105.7 0.0 5e-30 104.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW56616.1 - 1.9e-20 73.3 0.0 6.1e-19 68.5 0.0 2.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase PTPLA PF04387.14 CDW56617.1 - 8e-56 188.3 10.9 9.8e-56 188.0 10.9 1.1 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Paf67 PF10255.9 CDW56618.1 - 1.2e-124 416.4 10.0 1.7e-124 416.0 10.0 1.2 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 CDW56618.1 - 0.017 15.2 0.2 0.57 10.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Dimer_Tnp_hAT PF05699.14 CDW56620.1 - 0.019 14.7 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region Palm_thioest PF02089.15 CDW56622.1 - 8.9e-74 248.4 0.0 1e-73 248.1 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase LRR_6 PF13516.6 CDW56623.1 - 4e-11 42.1 5.1 0.0093 15.9 0.0 6.6 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 CDW56623.1 - 0.0013 19.0 0.6 67 4.6 0.0 5.6 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_4 PF12799.7 CDW56623.1 - 0.0022 18.3 6.3 2 9.0 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDW56623.1 - 0.12 12.1 6.0 0.75 9.6 0.1 3.7 4 0 0 4 4 4 0 Leucine rich repeat UQ_con PF00179.26 CDW56624.1 - 1.2e-31 109.2 0.0 1.7e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LPD5 PF18799.1 CDW56624.1 - 0.031 14.7 0.8 0.055 13.9 0.5 1.5 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 5 7tm_1 PF00001.21 CDW56625.1 - 3.3e-58 197.1 0.0 4.3e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW56625.1 - 1.8e-13 50.5 14.5 7e-12 45.3 9.9 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 CDW56625.1 - 1.3e-08 34.8 15.1 1.3e-08 34.8 15.1 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_4 PF13853.6 CDW56625.1 - 2.3e-05 24.3 10.9 0.011 15.4 3.8 2.4 2 1 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 CDW56625.1 - 0.0032 17.0 10.6 0.0032 17.0 10.6 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc ArfGap PF01412.18 CDW56626.1 - 1.6e-37 128.1 0.0 4.8e-37 126.6 0.0 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Ras PF00071.22 CDW56626.1 - 4e-16 59.0 0.0 8e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Ras family Ank_2 PF12796.7 CDW56626.1 - 1.1e-09 38.7 0.0 2.5e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDW56626.1 - 1.9e-05 24.9 0.0 0.0011 19.3 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 CDW56626.1 - 2.6e-05 24.4 0.1 0.00012 22.3 0.1 2.2 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW56626.1 - 0.00051 20.3 0.3 0.011 16.2 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat PH_11 PF15413.6 CDW56626.1 - 0.0007 20.0 0.4 0.0066 16.9 0.3 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain Ank_4 PF13637.6 CDW56626.1 - 0.0021 18.6 0.1 0.12 13.0 0.1 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Roc PF08477.13 CDW56626.1 - 0.005 17.1 0.0 0.19 12.0 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 CDW56626.1 - 0.0058 17.1 0.5 0.066 13.7 0.0 2.6 2 0 0 2 2 2 1 PH domain LSM PF01423.22 CDW56628.1 - 2.9e-20 71.7 0.2 3.3e-20 71.5 0.2 1.0 1 0 0 1 1 1 1 LSM domain zf-CCHC_2 PF13696.6 CDW56629.1 - 0.017 14.9 0.6 0.017 14.9 0.6 2.3 2 0 0 2 2 2 0 Zinc knuckle Asp_protease_2 PF13650.6 CDW56629.1 - 0.021 15.5 0.1 0.042 14.5 0.1 1.6 1 0 0 1 1 1 0 Aspartyl protease DUF3019 PF11456.8 CDW56629.1 - 0.021 15.3 0.6 8.2 7.0 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3019) K1 PF02960.14 CDW56629.1 - 0.1 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 K1 glycoprotein zf-CCHC_4 PF14392.6 CDW56629.1 - 1.4 8.7 6.0 0.47 10.2 2.7 2.0 2 0 0 2 2 2 0 Zinc knuckle Neur_chan_LBD PF02931.23 CDW56630.1 - 3e-64 216.4 0.7 1.7e-62 210.7 0.7 2.2 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW56630.1 - 2.8e-44 152.0 11.0 8.5e-44 150.4 11.0 1.7 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF4131 PF13567.6 CDW56630.1 - 2.2 7.9 4.0 4.1 7.0 4.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) BrkDBD PF09607.10 CDW56631.1 - 8e-14 51.2 0.5 8e-14 51.2 0.5 1.7 2 0 0 2 2 2 1 Brinker DNA-binding domain HTH_Tnp_Tc5 PF03221.16 CDW56631.1 - 1e-10 41.5 1.0 2.3e-10 40.4 0.2 1.9 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_Tnp_1 PF01527.20 CDW56631.1 - 1.9e-05 24.9 6.3 2.3e-05 24.6 2.0 2.3 1 1 1 2 2 2 1 Transposase HTH_28 PF13518.6 CDW56631.1 - 0.003 17.7 3.2 0.0041 17.2 0.9 2.5 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 CDW56631.1 - 0.011 15.5 0.0 0.031 14.1 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain HTH_29 PF13551.6 CDW56631.1 - 0.036 14.1 0.2 0.062 13.3 0.2 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_17 PF12728.7 CDW56631.1 - 0.41 10.9 5.9 0.13 12.4 1.8 2.2 2 1 0 2 2 2 0 Helix-turn-helix domain Rtf2 PF04641.12 CDW56632.1 - 9.9e-78 261.1 4.1 1.1e-77 260.9 4.1 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 CDW56632.1 - 0.0067 16.2 0.0 0.02 14.7 0.0 1.9 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 CDW56632.1 - 0.032 14.4 0.0 0.089 12.9 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Glyco_hydro_63N PF16923.5 CDW56632.1 - 0.075 13.1 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 N-terminal domain Proteasome PF00227.26 CDW56633.1 - 9e-58 194.9 0.0 1.3e-57 194.4 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDW56633.1 - 5.4e-15 54.8 2.6 2.6e-14 52.6 0.2 2.4 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Ets PF00178.22 CDW56634.1 - 6.4e-36 122.7 0.7 8.6e-36 122.3 0.7 1.2 1 0 0 1 1 1 1 Ets-domain Got1 PF04178.12 CDW56635.1 - 2.4e-14 53.7 16.3 7.1e-14 52.2 16.3 1.7 1 1 0 1 1 1 1 Got1/Sft2-like family DUF308 PF03729.13 CDW56635.1 - 0.0012 19.1 11.1 0.0012 19.1 11.1 1.8 1 1 0 1 1 1 1 Short repeat of unknown function (DUF308) MDM10 PF12519.8 CDW56635.1 - 0.071 12.0 0.0 0.087 11.7 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 XPG_N PF00752.17 CDW56636.1 - 8.2e-30 103.3 0.0 8.9e-30 103.2 0.0 1.0 1 0 0 1 1 1 1 XPG N-terminal domain NB-LRR PF12061.8 CDW56636.1 - 0.17 11.2 0.0 0.21 10.9 0.0 1.0 1 0 0 1 1 1 0 Late blight resistance protein R1 Radial_spoke PF04712.12 CDW56637.1 - 0.0023 17.0 3.3 0.0026 16.8 3.3 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein CpXC PF14353.6 CDW56637.1 - 0.038 14.0 0.2 0.05 13.7 0.2 1.4 1 1 0 1 1 1 0 CpXC protein Pox_A_type_inc PF04508.12 CDW56638.1 - 0.7 9.8 30.8 2.5 8.1 3.3 7.4 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat Spore_YhaL PF14147.6 CDW56638.1 - 3.8 7.3 7.6 11 5.8 1.9 3.4 3 0 0 3 3 3 0 Sporulation protein YhaL RRM_1 PF00076.22 CDW56639.1 - 1.9e-25 88.5 0.0 1e-17 63.7 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_13 PF17958.1 CDW56640.1 - 0.062 13.1 0.3 0.065 13.0 0.3 1.1 1 0 0 1 1 1 0 EF-hand domain RRM_1 PF00076.22 CDW56641.1 - 6.9e-11 41.8 0.1 4.1e-08 32.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW56641.1 - 0.012 15.7 0.0 0.018 15.1 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif Methyltransf_15 PF09445.10 CDW56642.1 - 1.2e-38 132.3 0.1 1.8e-38 131.7 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 CDW56642.1 - 1.7e-08 35.1 0.0 1.9e-07 31.7 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain UPF0020 PF01170.18 CDW56642.1 - 1e-06 28.6 0.0 5.5e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.16 CDW56642.1 - 1.5e-06 28.1 0.1 2.7e-06 27.3 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.6 CDW56642.1 - 8.7e-06 25.6 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDW56642.1 - 2e-05 24.3 0.0 4.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 CDW56642.1 - 2e-05 25.2 0.0 6.2e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW56642.1 - 0.0089 16.0 0.0 0.037 13.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDW56642.1 - 0.015 14.7 0.0 0.025 14.0 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) tRNA_U5-meth_tr PF05958.11 CDW56642.1 - 0.016 14.2 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase EF-hand_2 PF09068.11 CDW56643.1 - 1.2e-35 122.4 4.6 2.2e-35 121.5 2.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_3 PF09069.11 CDW56643.1 - 3.9e-34 116.9 0.3 2.5e-33 114.4 0.1 2.7 2 0 0 2 2 2 1 EF-hand ZZ PF00569.17 CDW56643.1 - 8.9e-16 57.4 7.0 2.1e-15 56.3 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type Spectrin PF00435.21 CDW56643.1 - 3.2e-10 40.4 90.1 2.5e-05 24.7 0.3 11.3 11 1 1 12 12 12 7 Spectrin repeat WW PF00397.26 CDW56643.1 - 3e-06 27.2 1.0 6.3e-06 26.2 1.0 1.5 1 0 0 1 1 1 1 WW domain C1_2 PF03107.16 CDW56643.1 - 0.0011 19.3 4.9 0.0024 18.1 4.9 1.6 1 0 0 1 1 1 1 C1 domain DUF5044 PF16447.5 CDW56643.1 - 0.12 12.2 0.1 0.31 10.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5044) FAA_hydro_N_2 PF18288.1 CDW56643.1 - 0.4 11.1 6.8 1.4 9.3 0.7 4.7 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 DUF2683 PF10884.8 CDW56643.1 - 6.5 7.1 6.0 1e+02 3.3 0.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2683) Trypsin PF00089.26 CDW56644.1 - 2.1e-07 31.0 0.0 4.6e-07 29.9 0.0 1.6 1 1 0 1 1 1 1 Trypsin Glyco_transf_41 PF13844.6 CDW56646.1 - 2.3e-250 830.9 0.0 3e-250 830.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.28 CDW56646.1 - 1.9e-88 287.0 28.2 8.7e-09 34.8 0.0 12.8 14 0 0 14 14 13 11 Tetratricopeptide repeat TPR_11 PF13414.6 CDW56646.1 - 2.8e-81 267.0 34.4 3.9e-10 39.2 0.8 12.3 3 3 9 12 12 12 12 TPR repeat TPR_2 PF07719.17 CDW56646.1 - 1.1e-65 212.5 22.3 7.7e-06 25.6 0.0 13.0 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_17 PF13431.6 CDW56646.1 - 2.4e-56 184.1 26.8 0.00017 21.7 0.0 13.0 13 0 0 13 13 12 11 Tetratricopeptide repeat TPR_8 PF13181.6 CDW56646.1 - 1.2e-55 181.1 14.8 0.00031 20.7 0.0 12.5 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_16 PF13432.6 CDW56646.1 - 1.3e-39 134.5 6.0 4e-07 30.6 0.5 7.8 4 2 3 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 CDW56646.1 - 1.5e-39 134.1 27.1 6.7e-09 35.9 0.9 8.8 5 2 2 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.6 CDW56646.1 - 1.2e-36 125.0 21.2 2.5e-06 27.9 0.0 7.9 4 2 3 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 CDW56646.1 - 4.7e-33 110.8 10.8 0.0085 16.1 0.0 12.5 12 0 0 12 12 12 8 Tetratricopeptide repeat TPR_14 PF13428.6 CDW56646.1 - 1.5e-32 109.5 15.6 0.016 16.0 0.2 13.1 4 3 9 13 13 13 9 Tetratricopeptide repeat TPR_10 PF13374.6 CDW56646.1 - 7.2e-29 98.8 44.6 0.0002 21.1 0.3 12.6 13 0 0 13 13 12 5 Tetratricopeptide repeat TPR_9 PF13371.6 CDW56646.1 - 7.3e-15 54.9 8.6 0.0019 18.3 0.3 6.3 3 2 5 8 8 8 4 Tetratricopeptide repeat NARP1 PF12569.8 CDW56646.1 - 2.6e-10 39.8 3.5 0.011 14.7 0.0 4.9 1 1 2 5 5 5 3 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 CDW56646.1 - 1.6e-09 37.8 8.5 1.5 9.6 0.0 9.1 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW56646.1 - 6.7e-09 35.6 13.1 0.00022 20.7 0.3 5.0 1 1 5 6 6 6 2 MalT-like TPR region TPR_4 PF07721.14 CDW56646.1 - 1.3e-08 34.7 0.5 0.2 12.4 0.1 7.2 8 0 0 8 8 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 CDW56646.1 - 6.8e-06 26.0 0.4 1.1 9.3 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDW56646.1 - 1.2e-05 24.7 5.4 0.0055 16.0 1.2 3.2 1 1 1 2 2 2 2 Tetratricopeptide repeat EST1_DNA_bind PF10373.9 CDW56646.1 - 2.3e-05 24.0 10.6 0.16 11.4 0.0 4.5 4 1 0 4 4 4 2 Est1 DNA/RNA binding domain FAT PF02259.23 CDW56646.1 - 5.9e-05 22.5 0.7 0.16 11.2 0.1 5.2 1 1 1 2 2 2 1 FAT domain SHNi-TPR PF10516.9 CDW56646.1 - 0.00084 18.7 0.4 5.7 6.5 0.0 4.9 5 0 0 5 5 5 1 SHNi-TPR MIT PF04212.18 CDW56646.1 - 0.0041 17.2 17.9 7.1 6.8 0.0 8.6 9 1 0 9 9 8 0 MIT (microtubule interacting and transport) domain SNAP PF14938.6 CDW56646.1 - 0.017 14.6 16.5 0.46 9.9 1.2 4.8 1 1 2 4 4 4 0 Soluble NSF attachment protein, SNAP BTAD PF03704.17 CDW56646.1 - 0.05 14.0 11.5 9.3 6.7 1.3 4.5 2 1 3 5 5 5 0 Bacterial transcriptional activator domain TPR_21 PF09976.9 CDW56646.1 - 0.45 10.2 8.2 14 5.3 0.3 4.4 1 1 4 6 6 6 0 Tetratricopeptide repeat-like domain Mad3_BUB1_I PF08311.12 CDW56646.1 - 0.53 10.3 11.4 32 4.5 0.0 6.4 5 2 2 7 7 6 0 Mad3/BUB1 homology region 1 DUF627 PF04781.12 CDW56646.1 - 1.1 9.3 5.0 1.2e+02 2.7 0.0 4.9 2 1 2 4 4 4 0 Protein of unknown function (DUF627) TPR_20 PF14561.6 CDW56646.1 - 3.2 8.2 6.0 19 5.7 0.0 4.4 4 1 0 5 5 4 0 Tetratricopeptide repeat cNMP_binding PF00027.29 CDW56648.1 - 0.0021 18.1 0.0 0.0037 17.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Pro-NT_NN PF07421.11 CDW56648.1 - 0.023 15.0 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor DEP PF00610.21 CDW56649.1 - 5e-18 64.9 0.3 1.1e-17 63.8 0.3 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) cNMP_binding PF00027.29 CDW56649.1 - 2.4e-17 62.8 0.0 4.9e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RasGEF_N PF00618.20 CDW56649.1 - 7.4e-09 35.8 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 RasGEF N-terminal motif PTPlike_phytase PF14566.6 CDW56650.1 - 0.14 12.3 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Inositol hexakisphosphate WD40 PF00400.32 CDW56651.1 - 1.1e-50 168.5 20.8 9.7e-09 35.7 0.1 7.4 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56651.1 - 9.7e-23 80.3 0.3 5.6e-05 23.4 0.0 5.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW56651.1 - 3.3e-09 36.9 0.0 0.0033 17.3 0.0 4.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDW56651.1 - 1.6e-07 30.6 2.1 0.079 11.9 0.0 4.2 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDW56651.1 - 2e-05 23.5 1.6 0.7 8.5 0.0 4.6 2 2 4 6 6 6 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 CDW56651.1 - 0.00093 18.2 0.1 1.2 8.0 0.0 2.6 2 1 0 2 2 2 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 CDW56651.1 - 0.0011 18.3 0.0 0.19 11.0 0.0 2.3 2 0 0 2 2 2 1 WD40-like domain Cytochrom_D1 PF02239.16 CDW56651.1 - 0.0029 16.2 0.0 1.1 7.8 0.0 3.1 3 1 0 3 3 3 1 Cytochrome D1 heme domain Ta0938 PF11494.8 CDW56651.1 - 0.0067 16.7 0.5 0.02 15.2 0.2 1.9 2 0 0 2 2 2 1 Ta0938 PD40 PF07676.12 CDW56651.1 - 0.0073 16.2 0.1 1.6 8.8 0.0 2.8 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Frtz PF11768.8 CDW56651.1 - 0.019 13.3 0.5 1.7 6.9 0.0 2.7 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Sec16_C PF12931.7 CDW56651.1 - 0.024 14.3 0.1 0.033 13.8 0.1 1.2 1 0 0 1 1 1 0 Sec23-binding domain of Sec16 Hira PF07569.11 CDW56651.1 - 0.052 13.3 0.1 5.5 6.6 0.0 2.7 3 0 0 3 3 3 0 TUP1-like enhancer of split IKI3 PF04762.12 CDW56651.1 - 0.21 9.6 0.0 0.3 9.0 0.0 1.4 1 0 0 1 1 1 0 IKI3 family PID PF00640.23 CDW56652.1 - 9.6e-18 64.6 0.0 1.8e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH3_9 PF14604.6 CDW56652.1 - 5.9e-11 42.1 0.0 6.7e-10 38.7 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 CDW56652.1 - 1.6e-09 37.2 0.0 7.8e-08 31.8 0.0 2.8 3 0 0 3 3 3 1 SH3 domain PTB PF08416.13 CDW56652.1 - 3.4e-07 30.5 0.0 8.4e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 CDW56652.1 - 1e-06 28.8 0.1 2.8e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) HH_signal PF01085.18 CDW56653.1 - 1e-68 230.0 0.0 1.4e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain Hint PF01079.20 CDW56653.1 - 7.5e-50 169.4 0.0 1.1e-49 168.9 0.0 1.1 1 0 0 1 1 1 1 Hint module Peptidase_M15_3 PF08291.11 CDW56653.1 - 0.00012 22.2 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase M15 Vint PF14623.6 CDW56653.1 - 0.024 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 Hint-domain Intein_splicing PF14890.6 CDW56653.1 - 0.028 14.3 0.0 0.16 11.9 0.0 2.1 1 1 0 1 1 1 0 Intein splicing domain DJ-1_PfpI PF01965.24 CDW56654.1 - 3.6e-51 173.3 0.2 4.1e-51 173.1 0.2 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CDW56654.1 - 0.00052 19.8 0.0 0.0012 18.6 0.0 1.6 2 1 0 2 2 2 1 ThiJ/PfpI family-like GATase_3 PF07685.14 CDW56654.1 - 0.022 14.3 0.1 0.035 13.7 0.1 1.3 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain VWA PF00092.28 CDW56654.1 - 0.13 12.5 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain HEPN_SAV2148 PF18725.1 CDW56655.1 - 0.00026 20.5 6.2 13 5.1 0.0 5.1 5 0 0 5 5 5 3 SAV2148-like HEPN Stevor PF17410.2 CDW56655.1 - 0.0051 16.4 0.0 89 2.5 0.0 5.5 7 0 0 7 7 7 0 Subtelomeric Variable Open Reading frame ETF_alpha PF00766.19 CDW56655.1 - 0.045 13.8 6.7 1.2e+02 2.9 0.1 5.6 6 0 0 6 6 6 0 Electron transfer flavoprotein FAD-binding domain UcrQ PF02939.16 CDW56656.1 - 1.1e-11 44.5 0.2 1.4e-11 44.1 0.2 1.1 1 0 0 1 1 1 1 UcrQ family HLH PF00010.26 CDW56658.1 - 7e-09 35.5 1.2 1.3e-08 34.7 1.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DNA_ligase_A_N PF04675.14 CDW56658.1 - 0.13 12.5 0.1 0.17 12.2 0.1 1.1 1 0 0 1 1 1 0 DNA ligase N terminus Glyco_transf_11 PF01531.16 CDW56659.1 - 7.1e-07 28.7 0.0 1e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 11 Motile_Sperm PF00635.26 CDW56661.1 - 3.9e-10 39.5 0.2 8.5e-10 38.5 0.0 1.7 2 0 0 2 2 2 1 MSP (Major sperm protein) domain ASH PF15780.5 CDW56661.1 - 0.0027 17.9 1.3 0.0039 17.4 0.3 1.8 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Alliinase_C PF04864.13 CDW56661.1 - 0.054 12.4 0.1 0.49 9.2 0.0 2.0 2 0 0 2 2 2 0 Allinase MOZ_SAS PF01853.18 CDW56663.1 - 3e-82 274.6 3.0 4.1e-82 274.2 3.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CDW56663.1 - 5.3e-22 77.2 0.3 5.3e-22 77.2 0.3 2.5 3 0 0 3 3 3 1 MYST family zinc finger domain Tudor-knot PF11717.8 CDW56663.1 - 7.5e-13 48.2 0.8 1.5e-12 47.2 0.8 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 CDW56663.1 - 0.00012 22.5 0.0 0.0003 21.2 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDW56663.1 - 0.0021 18.3 0.0 0.0044 17.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family zf-met PF12874.7 CDW56663.1 - 0.51 10.8 2.9 0.34 11.4 0.3 2.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type ATP-grasp_2 PF08442.10 CDW56664.1 - 7.5e-64 215.0 0.0 1.2e-63 214.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 CDW56664.1 - 2.2e-20 73.0 0.2 3.7e-20 72.3 0.2 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CDW56664.1 - 9.8e-05 21.9 0.2 0.00017 21.1 0.2 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CDW56664.1 - 0.002 17.9 0.0 0.0042 16.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain MSP1b PF03429.13 CDW56664.1 - 0.029 12.5 0.0 0.047 11.8 0.0 1.2 1 0 0 1 1 1 0 Major surface protein 1B WH1 PF00568.23 CDW56665.1 - 3.3e-20 72.1 0.0 6.9e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 CDW56665.1 - 3.2e-09 37.0 0.0 1e-08 35.4 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain CAP PF00188.26 CDW56665.1 - 1.1e-08 35.9 4.8 0.00069 20.5 0.5 2.9 2 0 0 2 2 2 2 Cysteine-rich secretory protein family WH2 PF02205.20 CDW56665.1 - 1.7e-06 27.6 2.0 0.0027 17.5 0.1 3.1 3 0 0 3 3 3 2 WH2 motif CAP_N PF01213.19 CDW56665.1 - 6.6e-05 22.6 3.8 6.6e-05 22.6 3.8 3.2 1 1 2 3 3 3 1 Adenylate cyclase associated (CAP) N terminal CAP PF00188.26 CDW56666.1 - 0.00024 21.9 0.8 0.00062 20.6 0.8 1.7 1 1 0 1 1 1 1 Cysteine-rich secretory protein family PfkB PF00294.24 CDW56667.1 - 2.7e-63 214.1 0.0 3.3e-63 213.8 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase RINGv PF12906.7 CDW56668.1 - 4.9e-17 61.8 12.2 1.4e-16 60.3 12.2 1.8 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CDW56668.1 - 0.0013 19.0 11.5 0.0013 19.0 11.5 2.2 2 0 0 2 2 2 1 Ring finger domain FANCL_C PF11793.8 CDW56668.1 - 1.1 9.5 10.3 0.58 10.4 6.7 2.4 3 1 0 3 3 3 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 CDW56668.1 - 3.8 7.6 11.5 1.6 8.8 7.7 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger UQ_con PF00179.26 CDW56669.1 - 1.8e-37 128.1 0.0 2.2e-37 127.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme 2OG-FeII_Oxy_2 PF13532.6 CDW56670.1 - 1.7e-37 129.6 0.0 2e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BHD_3 PF10405.9 CDW56671.1 - 1.3e-25 89.6 0.0 2.7e-25 88.6 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 CDW56671.1 - 2.9e-17 62.2 1.3 6.8e-17 61.0 0.8 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 CDW56671.1 - 5.8e-14 52.0 0.3 1e-13 51.2 0.3 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_2 PF10404.9 CDW56671.1 - 6.1e-10 39.9 3.4 2.9e-09 37.7 3.4 2.2 1 1 0 1 1 1 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 CDW56671.1 - 0.0019 18.6 0.0 0.0064 16.9 0.0 1.8 1 1 0 1 1 1 1 Transglutaminase-like superfamily JAB PF01398.21 CDW56672.1 - 8e-15 54.9 1.3 1.2e-14 54.3 0.1 1.9 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 CDW56672.1 - 3.6e-14 52.9 0.3 3.2e-13 49.9 1.7 1.7 2 0 0 2 2 2 1 USP8 dimerisation domain Prok-JAB PF14464.6 CDW56672.1 - 1.9e-05 24.4 0.1 5.4e-05 23.0 0.0 1.8 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain AATF-Che1 PF13339.6 CDW56672.1 - 0.048 14.3 0.1 0.079 13.6 0.1 1.4 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor WAPL PF07814.13 CDW56673.1 - 6.3e-25 87.7 9.6 1.2e-15 57.2 2.5 2.7 2 1 1 3 3 3 2 Wings apart-like protein regulation of heterochromatin BRK PF07533.16 CDW56674.1 - 0.00065 19.3 2.4 0.08 12.6 0.0 2.8 3 0 0 3 3 3 2 BRK domain Galactosyl_T PF01762.21 CDW56675.1 - 2.1e-28 99.5 0.2 8.1e-28 97.6 0.2 1.8 1 1 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.6 CDW56675.1 - 0.013 15.0 0.1 0.028 13.9 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase family 21 DUF2062 PF09835.9 CDW56675.1 - 0.05 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) Galactosyl_T PF01762.21 CDW56676.1 - 1.7e-33 116.1 0.0 2.5e-33 115.6 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Glyco_transf_21 PF13506.6 CDW56676.1 - 0.02 14.4 0.0 0.05 13.1 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferase family 21 Chromo PF00385.24 CDW56678.1 - 1e-17 63.8 0.1 8e-17 60.9 0.2 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 CDW56678.1 - 1.1e-16 60.7 0.0 3.4e-14 52.7 0.0 2.3 2 0 0 2 2 2 2 Chromo shadow domain Mtf2_C PF14061.6 CDW56678.1 - 0.069 13.3 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Eapp_C PF10238.9 CDW56679.1 - 8.2e-45 152.5 5.8 8.2e-45 152.5 5.8 1.8 2 0 0 2 2 2 1 E2F-associated phosphoprotein IBR PF01485.21 CDW56679.1 - 0.035 14.3 5.1 0.068 13.4 1.3 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain DUF5595 PF18077.1 CDW56679.1 - 0.038 14.1 0.7 0.27 11.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) Yippee-Mis18 PF03226.14 CDW56679.1 - 0.084 13.1 2.5 3.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly C1_4 PF07975.12 CDW56679.1 - 2.5 8.4 7.0 0.42 10.9 0.8 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain DZR PF12773.7 CDW56679.1 - 3.4 7.8 9.7 13 5.9 0.3 2.7 2 1 0 2 2 2 0 Double zinc ribbon SGS PF05002.15 CDW56680.1 - 3.7e-18 65.4 0.4 3.8e-18 65.4 0.4 1.0 1 0 0 1 1 1 1 SGS domain CwfJ_C_2 PF04676.14 CDW56681.1 - 3e-20 72.9 0.0 4e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 CDW56681.1 - 2.9e-19 69.1 0.4 4.1e-19 68.6 0.4 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 zf-RING_2 PF13639.6 CDW56681.1 - 0.054 13.8 2.3 0.054 13.8 2.3 2.2 1 1 1 2 2 2 0 Ring finger domain PAN_1 PF00024.26 CDW56682.1 - 1.9e-05 24.5 1.0 2.8e-05 24.0 1.0 1.4 1 0 0 1 1 1 1 PAN domain V-SNARE_C PF12352.8 CDW56684.1 - 1e-11 44.9 0.8 2.2e-11 43.8 0.3 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CDW56684.1 - 3.6e-05 23.6 1.3 7.1e-05 22.7 0.1 1.9 2 0 0 2 2 2 1 Sec20 F-actin_cap_A PF01267.17 CDW56684.1 - 0.03 13.8 0.7 0.036 13.5 0.7 1.1 1 0 0 1 1 1 0 F-actin capping protein alpha subunit XRN_N PF03159.18 CDW56684.1 - 0.13 11.7 0.5 1.3 8.4 0.1 2.1 2 0 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus EF-G-binding_N PF07299.11 CDW56684.1 - 0.18 12.3 3.0 0.2 12.2 1.4 1.8 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal RRM_1 PF00076.22 CDW56685.1 - 2.7e-24 84.8 0.1 9.6e-24 83.0 0.0 2.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF2_hinge PF14327.6 CDW56685.1 - 1.6e-13 50.9 2.6 1.6e-13 50.9 2.6 1.9 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 CDW56685.1 - 4.8e-12 45.3 3.4 4.8e-12 45.3 3.4 2.7 2 1 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_Rrp7 PF17799.1 CDW56685.1 - 0.0052 16.6 0.0 0.16 11.8 0.0 2.3 1 1 1 2 2 2 1 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 CDW56685.1 - 0.0097 16.0 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif RRM_3 PF08777.11 CDW56685.1 - 0.16 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif Sigma70_r4_2 PF08281.12 CDW56685.1 - 0.25 11.0 1.6 2 8.2 0.1 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 AAA PF00004.29 CDW56686.1 - 4.6e-40 137.1 0.0 9e-40 136.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW56686.1 - 6.3e-05 23.3 0.0 0.0073 16.6 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 CDW56686.1 - 9.7e-05 22.4 0.0 0.00052 20.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 CDW56686.1 - 0.00011 21.9 0.2 0.00026 20.7 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CDW56686.1 - 0.00031 21.2 0.2 0.0042 17.5 0.0 2.5 2 1 0 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 CDW56686.1 - 0.0022 17.2 0.0 0.004 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_2 PF07724.14 CDW56686.1 - 0.0022 18.1 0.0 0.0049 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CDW56686.1 - 0.0048 16.7 0.0 0.0095 15.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 CDW56686.1 - 0.009 15.7 0.4 0.12 12.1 0.0 2.8 3 1 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CDW56686.1 - 0.014 15.5 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDW56686.1 - 0.016 15.5 0.0 0.029 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDW56686.1 - 0.016 14.7 0.0 0.04 13.4 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CDW56686.1 - 0.032 14.8 0.0 0.069 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDW56686.1 - 0.04 13.3 0.1 0.12 11.8 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CDW56686.1 - 0.05 14.0 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Prot_ATP_ID_OB PF16450.5 CDW56686.1 - 0.064 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Sigma54_activ_2 PF14532.6 CDW56686.1 - 0.069 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.13 CDW56686.1 - 0.079 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_3 PF07726.11 CDW56686.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CDW56686.1 - 0.12 12.0 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 CDW56686.1 - 0.14 12.2 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDW56686.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein zf-C2H2_4 PF13894.6 CDW56687.1 - 5.1e-26 89.1 191.6 0.046 14.6 1.0 23.9 24 0 0 24 24 24 18 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW56687.1 - 2.8e-07 30.6 179.4 0.021 15.3 0.1 22.9 23 0 0 23 23 23 11 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CDW56687.1 - 0.0011 19.2 2.4 0.0011 19.2 2.4 16.8 7 3 9 17 17 17 3 C2H2 type zinc-finger (2 copies) zf_C2H2_ZHX PF18387.1 CDW56687.1 - 0.038 13.6 0.1 0.038 13.6 0.1 9.7 10 2 2 12 12 12 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 CDW56687.1 - 0.093 13.4 0.1 0.093 13.4 0.1 12.1 7 4 8 15 15 15 0 Zinc finger C2H2-type, 3 repeats PCI PF01399.27 CDW56688.1 - 2.4e-11 44.1 0.0 5e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 PCI domain zf-RING_9 PF13901.6 CDW56689.1 - 8.7e-64 215.3 14.0 8.7e-64 215.3 14.0 2.6 2 1 0 2 2 2 1 Putative zinc-RING and/or ribbon C1_1 PF00130.22 CDW56689.1 - 4.6e-07 29.6 7.5 4.6e-07 29.6 7.5 4.2 3 1 1 4 4 4 2 Phorbol esters/diacylglycerol binding domain (C1 domain) TPR_MLP1_2 PF07926.12 CDW56689.1 - 0.13 12.3 1.1 6.4 6.8 0.4 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Herpes_IR6 PF06307.12 CDW56689.1 - 0.16 11.5 0.0 3.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Herpesvirus IR6 protein DUF4508 PF14969.6 CDW56689.1 - 0.17 12.2 0.9 0.62 10.4 0.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4508) DNA_RNApol_7kD PF03604.13 CDW56689.1 - 1.1 8.9 11.3 5.2 6.8 0.3 4.1 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit ADK_lid PF05191.14 CDW56689.1 - 8.6 6.4 9.3 2.5 8.1 1.1 3.3 3 0 0 3 3 3 0 Adenylate kinase, active site lid VWA_N PF08399.11 CDW56690.1 - 4e-27 95.2 0.1 9.9e-27 93.9 0.1 1.7 1 0 0 1 1 1 1 VWA N-terminal VWA_3 PF13768.6 CDW56690.1 - 1.4e-16 60.8 0.0 3.6e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CDW56690.1 - 2.6e-14 53.8 0.0 5.4e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CDW56690.1 - 7.6e-14 52.3 0.0 2e-13 50.9 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain dCache_1 PF02743.18 CDW56690.1 - 3.4e-13 50.0 0.5 2.5e-11 43.9 0.1 2.7 3 0 0 3 3 3 1 Cache domain VGCC_alpha2 PF08473.11 CDW56690.1 - 1.3e-08 34.1 0.0 0.043 12.6 0.0 3.5 2 1 1 3 3 3 3 Neuronal voltage-dependent calcium channel alpha 2acd DUF3541 PF12060.8 CDW56690.1 - 0.063 13.0 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3541) Peptidase_M3 PF01432.20 CDW56691.1 - 2.6e-40 139.1 0.2 7.6e-23 81.5 0.0 3.4 2 1 1 3 3 3 2 Peptidase family M3 DcpS_C PF11969.8 CDW56691.1 - 1.5e-23 83.4 0.0 3.7e-23 82.2 0.0 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 CDW56691.1 - 1.2e-14 55.0 0.0 3e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal Peptidase_M49 PF03571.15 CDW56691.1 - 0.021 13.2 0.0 0.038 12.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M49 Uso1_p115_head PF04869.14 CDW56692.1 - 1.1e-54 185.7 0.4 1.6e-52 178.6 0.0 2.5 2 1 0 2 2 2 2 Uso1 / p115 like vesicle tethering protein, head region MAM PF00629.23 CDW56692.1 - 4.6e-20 72.2 0.6 1.9e-09 37.7 0.0 4.7 4 0 0 4 4 4 3 MAM domain, meprin/A5/mu Arm_vescicular PF18770.1 CDW56692.1 - 1.6e-15 56.8 1.4 8.4e-15 54.4 1.4 2.3 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor Uso1_p115_C PF04871.13 CDW56692.1 - 7.6e-06 26.3 6.2 7.6e-06 26.3 6.2 2.8 2 1 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region Cnd1 PF12717.7 CDW56692.1 - 0.01 15.9 0.5 0.071 13.1 0.1 2.7 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Mo25 PF08569.11 CDW56692.1 - 0.03 13.7 0.1 0.03 13.7 0.1 3.3 4 0 0 4 4 4 0 Mo25-like Arm PF00514.23 CDW56692.1 - 1.9 8.7 11.6 7.6 6.7 0.1 5.7 5 1 1 6 6 6 0 Armadillo/beta-catenin-like repeat Cnn_1N PF07989.11 CDW56692.1 - 2.2 8.5 11.1 21 5.4 0.4 3.3 2 2 0 2 2 2 0 Centrosomin N-terminal motif 1 PRKG1_interact PF15898.5 CDW56692.1 - 4.6 8.2 15.5 7.6e+02 1.1 11.5 3.4 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 CDW56692.1 - 9.7 6.0 11.6 1.4 8.7 0.7 3.5 3 0 0 3 3 3 0 Septum formation initiator P4Ha_N PF08336.11 CDW56693.1 - 8.5e-63 210.4 2.4 4e-36 124.0 2.1 2.9 3 0 0 3 3 3 2 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 CDW56693.1 - 3e-31 108.2 8.2 1.8e-14 54.4 0.1 4.4 2 1 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 CDW56693.1 - 5.8e-14 52.4 2.5 1.1e-05 25.8 0.0 3.7 2 1 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.17 CDW56693.1 - 6e-07 29.1 11.3 0.0017 18.3 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW56693.1 - 6.3e-06 26.3 1.1 1.2 9.4 0.1 4.8 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 CDW56693.1 - 0.00013 21.9 1.1 0.059 13.4 0.2 3.1 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 CDW56693.1 - 0.012 16.1 1.0 1.9 9.0 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat SPO22 PF08631.10 CDW56693.1 - 0.026 14.0 0.0 2.9 7.3 0.0 2.5 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.6 CDW56693.1 - 0.06 14.2 0.1 2.8 9.0 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat UPAR_LY6_2 PF16975.5 CDW56695.1 - 0.66 10.2 8.3 0.25 11.5 4.0 2.5 2 1 0 2 2 2 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Toxin_TOLIP PF00087.21 CDW56695.1 - 0.83 9.9 6.9 0.36 11.1 0.9 2.5 2 0 0 2 2 2 0 Snake toxin and toxin-like protein Glyco_hydro_19 PF00182.19 CDW56696.1 - 1.3e-33 116.8 8.0 2e-27 96.6 1.5 2.1 2 0 0 2 2 2 2 Chitinase class I 40S_S4_C PF16121.5 CDW56697.1 - 0.15 11.7 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 40S ribosomal protein S4 C-terminus CAP_GLY PF01302.25 CDW56698.1 - 2.3e-20 72.4 0.5 3.6e-20 71.7 0.5 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 CDW56698.1 - 0.013 15.9 0.0 0.021 15.2 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2052 PF09747.9 CDW56699.1 - 2.1e-35 122.7 22.6 1.5e-18 67.7 8.7 2.4 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Peptidase_M28 PF04389.17 CDW56700.1 - 8.7e-32 110.4 0.0 2.8e-16 59.8 0.0 2.4 3 0 0 3 3 3 2 Peptidase family M28 Cdc6_C PF09079.11 CDW56701.1 - 2.2e-07 30.8 0.1 6.6e-07 29.2 0.1 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA PF00004.29 CDW56701.1 - 5.7e-05 23.5 0.0 0.00014 22.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 CDW56701.1 - 0.00029 20.9 0.0 0.00056 20.0 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain CAP PF00188.26 CDW56702.1 - 0.0014 19.4 0.9 0.0033 18.3 0.9 1.7 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Pkinase_Tyr PF07714.17 CDW56703.1 - 1e-70 238.0 0.0 1.9e-70 237.1 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW56703.1 - 5.7e-39 134.1 0.0 1.4e-38 132.8 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW56703.1 - 7.5e-12 45.2 0.0 3.2e-11 43.1 0.0 2.2 2 0 0 2 2 2 1 SH2 domain CAP PF00188.26 CDW56703.1 - 1.2e-07 32.7 1.6 4.3e-05 24.3 0.2 3.4 2 1 0 2 2 2 1 Cysteine-rich secretory protein family CUB PF00431.20 CDW56705.1 - 1.8e-23 83.0 0.1 3.2e-13 50.0 0.0 4.2 3 1 0 3 3 3 3 CUB domain Trypsin PF00089.26 CDW56705.1 - 1.4e-22 80.6 0.0 3.7e-22 79.2 0.0 1.6 2 0 0 2 2 2 1 Trypsin Ldl_recept_a PF00057.18 CDW56705.1 - 3.9e-10 39.8 8.5 8.7e-10 38.7 8.5 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A DUF1986 PF09342.11 CDW56705.1 - 3.5e-08 33.8 0.0 6.6e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) DUF316 PF03761.15 CDW56705.1 - 0.00044 19.9 0.1 0.0015 18.2 0.1 1.9 2 0 0 2 2 2 1 Chymotrypsin family Peptidase-S1 ADAM_CR PF08516.12 CDW56705.1 - 0.0072 16.7 3.5 0.017 15.5 3.5 1.6 1 0 0 1 1 1 1 ADAM cysteine-rich DUF1406 PF07190.11 CDW56705.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1406) DUF1757 PF08560.10 CDW56706.1 - 3.6e-16 59.5 0.0 1.2e-15 57.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1757) PCI PF01399.27 CDW56706.1 - 1.8e-11 44.5 0.4 4.5e-11 43.2 0.1 1.8 2 0 0 2 2 2 1 PCI domain SNAP PF14938.6 CDW56706.1 - 2e-05 24.2 0.1 3.7e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP NRBF2_MIT PF17169.4 CDW56706.1 - 0.028 14.6 0.2 0.079 13.2 0.2 1.8 1 0 0 1 1 1 0 MIT domain of nuclear receptor-binding factor 2 Romo1 PF10247.9 CDW56706.1 - 0.16 12.4 0.4 0.45 10.9 0.1 1.9 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 WAP PF00095.21 CDW56707.1 - 1.7e-21 76.3 33.4 3e-07 30.7 7.2 3.3 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' Dickkopf_N PF04706.12 CDW56707.1 - 1.9 9.0 32.1 63 4.2 3.9 3.5 2 1 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region Arm PF00514.23 CDW56708.1 - 1.2e-80 263.3 17.6 2.4e-13 49.6 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CDW56708.1 - 8.4e-27 93.2 1.8 7.2e-09 36.0 0.0 5.1 4 1 0 4 4 4 4 HEAT-like repeat IBB PF01749.20 CDW56708.1 - 1.4e-21 76.7 0.2 3e-21 75.6 0.2 1.5 1 0 0 1 1 1 1 Importin beta binding domain Arm_3 PF16186.5 CDW56708.1 - 3.8e-21 74.4 0.3 2.3e-20 71.9 1.4 1.7 2 0 0 2 2 2 1 Atypical Arm repeat HEAT PF02985.22 CDW56708.1 - 1.5e-18 65.3 7.6 0.0043 17.2 0.0 7.6 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.6 CDW56708.1 - 2.8e-17 62.9 0.1 0.00012 22.4 0.0 5.0 1 1 5 6 6 6 6 HEAT repeats RICTOR_V PF14668.6 CDW56708.1 - 2e-07 31.1 0.4 1.7 8.9 0.0 5.1 4 2 2 6 6 6 2 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 CDW56708.1 - 9.3e-05 22.5 0.0 0.038 14.1 0.0 3.3 4 0 0 4 4 4 1 V-ATPase subunit H HEAT_PBS PF03130.16 CDW56708.1 - 0.0037 17.8 4.2 16 6.5 0.0 6.0 7 0 0 7 7 7 1 PBS lyase HEAT-like repeat Arm_2 PF04826.13 CDW56708.1 - 0.012 15.1 0.0 5.1 6.5 0.1 2.5 1 1 0 2 2 2 0 Armadillo-like DUF4439 PF14530.6 CDW56708.1 - 0.12 13.0 0.0 29 5.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4439) PDEase_I PF00233.19 CDW56709.1 - 2.2e-63 214.2 9.1 2.2e-63 214.2 9.1 1.7 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 CDW56709.1 - 2.2e-06 28.3 0.5 1.7e-05 25.4 0.0 2.5 3 0 0 3 3 3 1 GAF domain GAF_2 PF13185.6 CDW56709.1 - 0.00024 21.4 0.0 0.0016 18.8 0.0 2.2 2 0 0 2 2 2 1 GAF domain Nefa_Nip30_N PF10187.9 CDW56710.1 - 8e-24 84.0 8.8 1.7e-23 83.0 8.8 1.6 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 GCIP PF13324.6 CDW56710.1 - 0.029 14.0 0.9 0.036 13.7 0.9 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Phenol_hyd_sub PF06099.11 CDW56710.1 - 0.051 13.6 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Phenol hydroxylase subunit UCH PF00443.29 CDW56711.1 - 9.9e-51 172.7 0.5 1.2e-50 172.4 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW56711.1 - 1.9e-16 60.5 9.1 4.7e-16 59.3 9.1 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CDW56711.1 - 3.5e-06 27.2 17.3 3.5e-06 27.2 17.3 2.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_C98 PF15499.6 CDW56711.1 - 9.1 5.7 21.3 2.2 7.7 3.9 3.5 3 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Peptidase_S9 PF00326.21 CDW56712.1 - 6.3e-32 110.8 0.0 8.4e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 CDW56712.1 - 1.1e-07 31.6 0.0 1.3e-06 28.2 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CDW56712.1 - 1.3e-06 27.8 0.0 0.001 18.4 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CDW56712.1 - 3.5e-06 27.0 0.0 7.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW56712.1 - 4.1e-06 27.6 0.1 6.4e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDW56712.1 - 3.5e-05 23.6 0.6 0.00036 20.3 0.4 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold BAAT_C PF08840.11 CDW56712.1 - 3.8e-05 23.7 0.0 8.8e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal PD40 PF07676.12 CDW56712.1 - 0.0013 18.6 1.4 0.25 11.3 0.0 3.3 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat FSH1 PF03959.13 CDW56712.1 - 0.0033 17.1 0.0 0.009 15.7 0.0 1.6 2 0 0 2 2 2 1 Serine hydrolase (FSH1) AXE1 PF05448.12 CDW56712.1 - 0.013 14.2 0.0 0.22 10.1 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Chlorophyllase2 PF12740.7 CDW56712.1 - 0.021 13.7 0.0 0.081 11.8 0.0 1.8 1 1 0 1 1 1 0 Chlorophyllase enzyme Esterase PF00756.20 CDW56712.1 - 0.022 14.4 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Abhydrolase_2 PF02230.16 CDW56712.1 - 0.026 14.3 0.0 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase COesterase PF00135.28 CDW56712.1 - 0.031 13.2 0.0 0.044 12.7 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family LSM PF01423.22 CDW56713.1 - 9.4e-18 63.7 0.1 1.9e-17 62.7 0.0 1.5 2 0 0 2 2 2 1 LSM domain Adeno_E3A PF05248.12 CDW56713.1 - 0.089 12.8 0.1 7.3 6.7 0.1 2.1 1 1 1 2 2 2 0 Adenovirus E3A SM-ATX PF14438.6 CDW56713.1 - 0.1 12.7 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Ataxin 2 SM domain Solute_trans_a PF03619.16 CDW56714.1 - 4.5e-41 141.1 6.7 5.6e-41 140.8 6.7 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha LIM PF00412.22 CDW56715.1 - 2.7e-19 69.1 21.9 4.5e-11 42.8 10.7 2.3 2 0 0 2 2 2 2 LIM domain C1_4 PF07975.12 CDW56715.1 - 0.95 9.8 20.2 3.8 7.8 7.6 3.1 2 1 1 3 3 3 0 TFIIH C1-like domain SET PF00856.28 CDW56716.1 - 5.4e-18 65.9 3.8 1.4e-17 64.6 0.0 3.1 2 2 0 2 2 2 1 SET domain SRI PF08236.11 CDW56716.1 - 0.00018 21.6 1.6 0.00022 21.3 0.2 1.9 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain Symplekin_C PF12295.8 CDW56717.1 - 2e-47 161.7 5.9 6.1e-47 160.1 5.9 1.9 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 CDW56717.1 - 1e-21 77.7 1.2 3e-21 76.1 0.3 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) UBD PF16455.5 CDW56718.1 - 2.2e-32 111.4 0.0 3.1e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-binding domain ubiquitin PF00240.23 CDW56718.1 - 3.7e-08 33.0 0.0 9.2e-08 31.7 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin family DUF2407 PF10302.9 CDW56718.1 - 0.054 14.1 0.0 0.086 13.4 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain RPEL PF02755.15 CDW56719.1 - 7e-20 70.1 8.7 2.3e-11 43.0 2.9 2.4 2 0 0 2 2 2 2 RPEL repeat EXOSC1 PF10447.9 CDW56721.1 - 1.2e-05 25.9 0.3 0.028 15.0 0.0 2.3 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 CDW56721.1 - 0.0025 17.6 0.1 0.0045 16.8 0.1 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region zf-C4 PF00105.18 CDW56722.1 - 2.9e-31 107.8 15.1 7.8e-31 106.4 15.1 1.8 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) RNA_pol_Rpb4 PF03874.16 CDW56722.1 - 0.074 13.4 0.1 0.11 12.9 0.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb4 COX7C PF02935.16 CDW56723.1 - 5.2e-06 26.6 0.0 6.3e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Fasciclin PF02469.22 CDW56724.1 - 1.5e-48 164.2 3.1 1.5e-20 73.7 0.1 6.1 5 1 1 6 6 6 6 Fasciclin domain LBP_BPI_CETP_C PF02886.17 CDW56725.1 - 8.1e-18 64.7 0.7 8.1e-18 64.7 0.7 1.9 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 CDW56725.1 - 0.0016 18.1 0.3 0.0032 17.1 0.3 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Urb2 PF10441.9 CDW56726.1 - 0.0029 17.6 2.6 0.0031 17.5 0.3 1.9 2 0 0 2 2 2 1 Urb2/Npa2 family zf-met PF12874.7 CDW56726.1 - 0.18 12.2 0.2 0.18 12.2 0.2 3.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DUF2197 PF09963.9 CDW56726.1 - 0.45 10.8 4.4 1.4 9.2 4.4 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) DWNN PF08783.11 CDW56727.1 - 9.9e-26 89.8 0.1 1.6e-25 89.1 0.1 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 CDW56727.1 - 3.3e-10 39.6 7.1 3.3e-10 39.6 7.1 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 CDW56727.1 - 0.00013 21.8 1.2 0.00013 21.8 1.2 2.8 3 0 0 3 3 3 1 Zinc knuckle zf-C3HC4_3 PF13920.6 CDW56727.1 - 0.0002 21.2 12.4 0.0002 21.2 12.4 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 CDW56727.1 - 0.0029 17.7 0.0 0.0089 16.2 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-C3HC4_2 PF13923.6 CDW56727.1 - 0.0034 17.2 14.0 0.0034 17.2 14.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW56727.1 - 0.047 13.6 14.2 0.13 12.1 14.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 CDW56727.1 - 0.16 11.9 8.2 0.36 10.7 8.2 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein TerY_C PF15616.6 CDW56727.1 - 1.3 9.2 7.2 0.37 10.9 3.2 2.0 2 0 0 2 2 2 0 TerY-C metal binding domain NIF PF03031.18 CDW56728.1 - 3.9e-22 78.7 0.3 9.3e-22 77.5 0.0 1.8 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase Biotin_lipoyl PF00364.22 CDW56728.1 - 0.00035 20.4 0.1 0.063 13.1 0.0 2.5 2 0 0 2 2 2 2 Biotin-requiring enzyme BRCT PF00533.26 CDW56728.1 - 0.00042 20.6 0.0 0.0011 19.3 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CDW56728.1 - 0.00055 19.8 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 CDW56728.1 - 0.078 13.3 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Aldo_ket_red PF00248.21 CDW56730.1 - 0 1163.6 0.0 7.3e-49 166.5 0.0 12.1 7 3 3 10 10 10 10 Aldo/keto reductase family RVT_3 PF13456.6 CDW56730.1 - 1.1e-12 47.8 0.3 2.2 8.1 0.0 7.8 8 0 0 8 8 8 3 Reverse transcriptase-like Nitrate_red_del PF02613.15 CDW56730.1 - 0.00025 21.1 0.3 40 4.2 0.0 6.6 7 0 0 7 7 7 0 Nitrate reductase delta subunit TMEM89 PF15098.6 CDW56730.1 - 0.00037 20.7 0.0 51 4.0 0.0 5.6 6 0 0 6 6 6 0 TMEM89 protein family RE_NgoBV PF09564.10 CDW56730.1 - 0.0018 17.8 3.4 51 3.2 0.0 6.7 8 0 0 8 8 8 0 NgoBV restriction endonuclease DUF2158 PF09926.9 CDW56730.1 - 0.01 15.5 4.0 87 3.0 0.0 6.8 8 0 0 8 8 8 0 Uncharacterized small protein (DUF2158) SKIP_SNW PF02731.15 CDW56730.1 - 0.027 14.1 0.3 27 4.4 0.0 4.0 4 0 0 4 4 4 0 SKIP/SNW domain SAM_DrpA PF18255.1 CDW56730.1 - 5.3 7.4 13.2 12 6.2 0.0 6.8 10 0 0 10 10 10 0 DNA processing protein A sterile alpha motif domain Sld5 PF05916.11 CDW56731.1 - 0.019 15.4 0.0 0.026 15.0 0.0 1.2 1 0 0 1 1 1 0 GINS complex protein Aldo_ket_red PF00248.21 CDW56732.1 - 6.5e-56 189.7 0.3 3e-38 131.7 0.0 3.0 1 1 2 3 3 3 3 Aldo/keto reductase family IF-2B PF01008.17 CDW56733.1 - 9.6e-73 244.8 0.0 1.1e-72 244.6 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF1529 PF07485.11 CDW56733.1 - 0.11 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1259) Erf4 PF10256.9 CDW56734.1 - 6.9e-07 29.4 0.0 8.8e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Lipoprotein_21 PF14041.6 CDW56734.1 - 0.16 12.1 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 LppP/LprE lipoprotein WD40 PF00400.32 CDW56735.1 - 2.7e-13 50.1 8.5 4.5e-06 27.3 0.9 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56735.1 - 7.5e-05 23.0 0.0 0.00098 19.4 0.0 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Strep_SA_rep PF06696.11 CDW56735.1 - 0.00012 21.9 3.6 0.00035 20.5 3.6 1.8 1 0 0 1 1 1 1 Streptococcal surface antigen repeat KELK PF15796.5 CDW56735.1 - 0.0023 18.3 2.0 0.0023 18.3 2.0 5.5 6 0 0 6 6 5 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF1664 PF07889.12 CDW56735.1 - 0.028 14.5 0.4 0.028 14.5 0.4 6.2 6 1 1 7 7 7 0 Protein of unknown function (DUF1664) Ge1_WD40 PF16529.5 CDW56735.1 - 0.043 12.8 0.0 2.2 7.1 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Golgin_A5 PF09787.9 CDW56735.1 - 0.35 10.3 53.7 0.024 14.1 13.1 4.8 4 1 1 5 5 5 0 Golgin subfamily A member 5 DUF2935 PF11155.8 CDW56735.1 - 0.49 10.7 2.8 27 5.1 0.1 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Sugarporin_N PF11471.8 CDW56735.1 - 0.67 10.0 14.5 2 8.5 0.3 3.9 4 0 0 4 4 4 0 Maltoporin periplasmic N-terminal extension MCPsignal PF00015.21 CDW56735.1 - 2.1 8.1 7.9 3.6 7.4 1.0 2.8 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ENT PF03735.14 CDW56735.1 - 2.7 8.1 8.9 5.6 7.1 0.3 3.7 2 1 1 3 3 3 0 ENT domain DUF948 PF06103.11 CDW56735.1 - 8 6.8 10.7 10 6.5 0.6 4.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Exo_endo_phos PF03372.23 CDW56736.1 - 2.5e-11 43.6 0.6 6.9e-11 42.1 0.6 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SPARC_Ca_bdg PF10591.9 CDW56737.1 - 7.8e-25 87.4 1.8 1.3e-24 86.7 1.8 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region FOLN PF09289.10 CDW56737.1 - 1.3e-09 38.0 6.6 1.3e-09 38.0 6.6 2.8 2 0 0 2 2 2 1 Follistatin/Osteonectin-like EGF domain Kazal_2 PF07648.15 CDW56737.1 - 0.00058 19.9 9.5 0.00058 19.9 9.5 2.9 2 1 1 3 3 3 1 Kazal-type serine protease inhibitor domain EF-hand_1 PF00036.32 CDW56737.1 - 0.01 15.3 0.0 0.055 13.0 0.0 2.2 2 0 0 2 2 2 0 EF hand Kazal_1 PF00050.21 CDW56737.1 - 0.022 14.8 7.8 0.022 14.8 7.8 3.0 2 2 1 3 3 3 0 Kazal-type serine protease inhibitor domain EF-hand_6 PF13405.6 CDW56737.1 - 0.038 13.9 0.0 0.32 11.0 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain HEAT_2 PF13646.6 CDW56739.1 - 4.3e-06 27.0 0.2 0.075 13.4 0.0 3.3 2 1 1 3 3 3 3 HEAT repeats HEAT PF02985.22 CDW56739.1 - 6e-05 23.0 12.9 0.0069 16.6 0.1 5.6 6 0 0 6 6 6 2 HEAT repeat Cnd3 PF12719.7 CDW56739.1 - 0.0036 16.5 1.9 0.024 13.8 0.0 2.5 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain Vac14_Fab1_bd PF12755.7 CDW56739.1 - 0.084 13.5 1.1 1.5 9.4 0.1 3.1 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region API5 PF05918.11 CDW56739.1 - 0.11 11.3 1.1 0.27 10.0 0.2 2.0 2 1 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) HEAT_EZ PF13513.6 CDW56739.1 - 0.14 12.7 0.1 3.5 8.2 0.0 3.2 2 1 1 3 3 3 0 HEAT-like repeat RTP1_C1 PF10363.9 CDW56739.1 - 0.18 12.0 0.1 2 8.6 0.0 2.2 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 CDW56739.1 - 3.7 7.6 7.4 0.51 10.4 0.4 3.0 3 2 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 MeaB PF03308.16 CDW56741.1 - 0.0028 16.7 0.0 0.0048 15.9 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 CDW56741.1 - 0.017 15.7 0.1 0.044 14.3 0.0 1.7 2 0 0 2 2 2 0 ABC transporter KAP_NTPase PF07693.14 CDW56741.1 - 0.025 13.8 0.1 0.06 12.6 0.0 1.8 2 0 0 2 2 2 0 KAP family P-loop domain AAA_18 PF13238.6 CDW56741.1 - 0.061 13.9 0.3 0.51 10.9 0.0 2.6 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 CDW56741.1 - 0.26 11.4 0.6 0.79 9.8 0.0 2.1 3 0 0 3 3 3 0 50S ribosome-binding GTPase HSP70 PF00012.20 CDW56742.1 - 1.5e-262 872.1 12.0 1.7e-262 872.0 12.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDW56742.1 - 6.1e-17 61.4 0.6 1.6e-15 56.8 0.2 2.2 2 0 0 2 2 2 1 MreB/Mbl protein DUF4624 PF15417.6 CDW56742.1 - 0.0038 17.0 0.0 1.6 8.6 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4624) Hydantoinase_A PF01968.18 CDW56742.1 - 0.055 12.7 4.2 0.089 12.0 0.3 2.8 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase FtsA PF14450.6 CDW56742.1 - 0.075 13.5 7.6 1.4 9.4 0.1 3.6 3 2 0 3 3 3 0 Cell division protein FtsA AAA_23 PF13476.6 CDW56742.1 - 0.55 10.7 10.2 1.5 9.3 5.7 2.3 2 0 0 2 2 2 0 AAA domain RSS_P20 PF11757.8 CDW56742.1 - 1.6 9.2 8.2 0.83 10.1 4.8 2.3 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain MIF4G_like_2 PF09090.11 CDW56742.1 - 7.4 6.0 10.4 10 5.5 3.7 2.3 2 0 0 2 2 2 0 MIF4G like DUF1542 PF07564.11 CDW56742.1 - 8.8 6.5 15.6 0.049 13.7 2.6 3.2 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1542) Med14 PF08638.11 CDW56743.1 - 7.1e-51 172.3 0.0 1.5e-50 171.3 0.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit MED14 PCO_ADO PF07847.12 CDW56744.1 - 9.6e-35 119.9 0.0 1.2e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 PCO_ADO CDO_I PF05995.12 CDW56744.1 - 0.0032 16.8 0.0 0.013 14.8 0.0 1.9 1 1 0 1 1 1 1 Cysteine dioxygenase type I Ribosomal_L14e PF01929.17 CDW56745.1 - 1.2e-21 77.0 10.9 1.8e-21 76.4 10.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 CDW56745.1 - 0.025 14.5 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 KOW motif ErmC PF06308.11 CDW56745.1 - 0.08 13.3 0.2 0.16 12.4 0.2 1.5 1 0 0 1 1 1 0 23S rRNA methylastransferase leader peptide (ErmCL) Herpes_UL25 PF01499.16 CDW56745.1 - 0.19 10.2 2.4 0.21 10.1 2.4 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family US30 PF17624.2 CDW56745.1 - 0.38 9.8 3.2 1.2 8.1 3.2 1.6 1 1 1 2 2 2 0 Family of unknown function PCMT PF01135.19 CDW56746.1 - 1.8e-79 266.3 0.0 2.2e-79 266.1 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CDW56746.1 - 6.7e-07 29.2 0.0 1.3e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW56746.1 - 6e-05 23.7 0.0 0.00011 22.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW56746.1 - 0.00032 21.3 0.0 0.00073 20.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDW56746.1 - 0.00093 18.7 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CDW56746.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 CDW56746.1 - 0.014 14.7 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family EF-hand_6 PF13405.6 CDW56746.1 - 0.03 14.2 0.0 0.33 11.0 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain Methyltransf_3 PF01596.17 CDW56746.1 - 0.044 13.0 0.0 0.069 12.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_23 PF13489.6 CDW56746.1 - 0.045 13.6 0.0 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 CDW56746.1 - 0.046 13.7 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 CDW56746.1 - 0.062 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase RrnaAD PF00398.20 CDW56746.1 - 0.24 10.5 0.0 0.32 10.0 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TTR-52 PF01060.23 CDW56747.1 - 3.9e-05 24.3 0.0 4.8e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Transthyretin-like family TTR-52 PF01060.23 CDW56748.1 - 5.4e-10 39.8 0.0 8.6e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Transthyretin-like family Biopterin_H PF00351.21 CDW56749.1 - 7.4e-108 360.5 3.3 1.3e-103 346.6 3.3 3.0 1 1 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase Thioredoxin PF00085.20 CDW56750.1 - 2e-28 98.4 0.3 2.3e-25 88.6 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 CDW56750.1 - 1e-21 77.7 1.9 1.1e-20 74.3 1.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 CDW56750.1 - 2.7e-08 33.5 0.4 0.0056 16.1 0.3 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CDW56750.1 - 4.3e-06 26.8 0.0 0.0017 18.5 0.0 2.7 2 1 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CDW56750.1 - 5e-06 26.7 0.3 0.0065 16.8 0.0 2.9 2 1 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 CDW56750.1 - 5.2e-06 26.4 0.2 0.0015 18.5 0.0 2.7 2 1 0 3 3 3 1 AhpC/TSA family Thioredoxin_2 PF13098.6 CDW56750.1 - 0.00012 22.5 1.5 0.0015 19.0 0.2 2.9 2 2 0 2 2 2 1 Thioredoxin-like domain Glutaredoxin PF00462.24 CDW56750.1 - 0.12 12.6 0.2 0.65 10.3 0.0 2.2 2 1 1 3 3 3 0 Glutaredoxin Redoxin PF08534.10 CDW56750.1 - 0.13 12.0 0.0 0.36 10.5 0.0 1.8 2 0 0 2 2 2 0 Redoxin Glyco_trans_1_2 PF13524.6 CDW56750.1 - 0.17 12.3 0.0 6.9 7.1 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferases group 1 DUF1674 PF07896.12 CDW56751.1 - 1.3e-19 70.4 3.2 3.4e-19 69.1 3.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Ribosomal_S8 PF00410.19 CDW56752.1 - 9.8e-23 80.5 0.0 1.5e-22 79.9 0.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 FlgI PF02119.16 CDW56752.1 - 0.14 11.1 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Flagellar P-ring protein COesterase PF00135.28 CDW56753.1 - 4.5e-132 441.5 0.0 5.7e-132 441.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW56753.1 - 1.7e-08 34.6 0.0 5.4e-08 32.9 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW56753.1 - 0.023 15.3 1.0 0.086 13.4 0.9 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family Filamin PF00630.19 CDW56754.1 - 5.1e-226 733.9 20.9 3.1e-19 69.7 0.1 20.3 19 1 1 20 20 20 20 Filamin/ABP280 repeat CH PF00307.31 CDW56754.1 - 3.3e-41 139.9 0.3 1e-22 80.4 0.6 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.13 CDW56754.1 - 1.1e-13 50.9 4.8 0.47 10.4 0.0 9.5 12 0 0 12 12 12 5 Y_Y_Y domain Big_3_5 PF16640.5 CDW56754.1 - 5.5e-09 36.1 0.9 0.48 10.6 0.0 8.6 10 0 0 10 10 10 1 Bacterial Ig-like domain (group 3) Invasin_D3 PF09134.10 CDW56754.1 - 8.5e-07 29.2 0.1 5.5 7.4 0.0 6.5 6 0 0 6 6 6 2 Invasin, domain 3 TIG PF01833.24 CDW56754.1 - 2.5e-05 24.3 7.3 0.048 13.7 0.1 6.8 8 0 0 8 8 8 1 IPT/TIG domain DUF5060 PF16586.5 CDW56754.1 - 0.00014 22.2 0.0 61 4.1 0.0 6.5 7 0 0 7 7 6 0 Domain of unknown function (DUF5060) EMP24_GP25L PF01105.24 CDW56754.1 - 0.0015 18.5 0.0 13 5.7 0.0 5.1 5 0 0 5 5 5 1 emp24/gp25L/p24 family/GOLD YtkA PF13115.6 CDW56754.1 - 0.0024 18.4 1.9 2.4e+02 2.4 0.0 7.3 9 0 0 9 9 9 0 YtkA-like CAMSAP_CH PF11971.8 CDW56754.1 - 0.016 15.0 0.0 1.4 8.8 0.0 2.6 2 0 0 2 2 2 0 CAMSAP CH domain CH_2 PF06294.11 CDW56754.1 - 0.054 13.6 0.6 2.7 8.2 0.1 2.4 2 0 0 2 2 2 0 CH-like domain in sperm protein SprB PF13573.6 CDW56754.1 - 0.057 13.2 16.3 2.5 7.9 0.7 5.4 5 0 0 5 5 5 0 SprB repeat He_PIG PF05345.12 CDW56754.1 - 3.4 7.9 4.8 15 5.9 0.0 4.7 6 0 0 6 6 5 0 Putative Ig domain wnt PF00110.19 CDW56755.1 - 6.9e-107 357.6 24.6 7.8e-107 357.4 24.6 1.0 1 0 0 1 1 1 1 wnt family DUF4709 PF15821.5 CDW56756.1 - 0.1 12.9 0.2 0.41 10.9 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4709) ubiquitin PF00240.23 CDW56757.1 - 6.1e-11 41.9 0.0 1.1e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CDW56757.1 - 7e-05 22.6 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 CDW56757.1 - 0.084 12.9 0.2 2.1 8.4 0.1 2.4 1 1 1 2 2 2 0 Ubiquitin-like domain PH_8 PF15409.6 CDW56757.1 - 0.093 13.0 0.1 0.24 11.7 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain XRCC4 PF06632.12 CDW56758.1 - 6.3e-18 64.7 2.2 8.1e-18 64.4 2.2 1.0 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 WEMBL PF05701.11 CDW56758.1 - 0.0016 17.3 3.0 0.0021 16.9 3.0 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light DUF4806 PF16064.5 CDW56758.1 - 0.0062 16.8 4.3 1.8 8.9 0.2 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4806) She9_MDM33 PF05546.11 CDW56758.1 - 0.0073 16.1 2.0 0.011 15.5 2.0 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family DUF573 PF04504.14 CDW56758.1 - 0.009 16.6 1.0 0.02 15.5 1.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Poxvirus_B22R PF04395.12 CDW56758.1 - 0.0091 15.6 1.7 0.011 15.4 0.9 1.5 1 1 1 2 2 2 1 Poxvirus B22R protein NYD-SP28 PF14772.6 CDW56758.1 - 0.01 15.9 5.8 0.082 13.0 0.3 2.4 1 1 1 2 2 2 0 Sperm tail CEP63 PF17045.5 CDW56758.1 - 0.018 15.0 3.3 0.031 14.2 2.1 1.8 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa HMMR_N PF15905.5 CDW56758.1 - 0.021 14.3 4.4 0.034 13.6 4.4 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal RIC3 PF15361.6 CDW56758.1 - 0.056 13.8 0.3 0.16 12.4 0.0 1.9 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 MAP7 PF05672.11 CDW56758.1 - 0.08 12.6 3.1 0.11 12.2 3.1 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family EFhand_Ca_insen PF08726.10 CDW56758.1 - 0.13 12.4 0.9 16 5.6 0.0 3.1 3 0 0 3 3 3 0 Ca2+ insensitive EF hand SOAR PF16533.5 CDW56758.1 - 0.25 11.3 3.0 0.71 9.9 0.5 2.3 1 1 1 2 2 2 0 STIM1 Orai1-activating region HR1 PF02185.16 CDW56758.1 - 0.45 10.7 6.3 7.9 6.7 1.4 2.8 3 0 0 3 3 3 0 Hr1 repeat Yippee-Mis18 PF03226.14 CDW56759.1 - 1.1e-10 41.7 0.0 1.3e-10 41.4 0.0 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 CDW56759.1 - 0.0027 17.9 0.1 0.0041 17.3 0.1 1.2 1 0 0 1 1 1 1 C-terminal domain of RIG-I DUF4879 PF16219.5 CDW56759.1 - 0.06 13.6 0.0 0.087 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4879) SelR PF01641.18 CDW56759.1 - 0.13 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 SelR domain Endonuclease_7 PF02945.15 CDW56759.1 - 0.2 11.6 1.1 0.82 9.6 0.7 2.0 1 1 1 2 2 2 0 Recombination endonuclease VII Pyr_redox_2 PF07992.14 CDW56761.1 - 9.3e-69 231.9 4.2 1.4e-68 231.2 4.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDW56761.1 - 1.9e-34 118.2 0.1 1e-33 115.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDW56761.1 - 5.2e-19 68.6 4.8 1.4e-15 57.6 1.3 3.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDW56761.1 - 2.7e-10 40.2 3.6 1.5e-09 37.7 0.4 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CDW56761.1 - 4.7e-09 35.8 3.3 1.1e-07 31.3 0.2 2.8 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_3 PF13738.6 CDW56761.1 - 1.6e-08 34.2 2.3 2e-05 24.0 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW56761.1 - 2e-07 31.1 2.5 0.00028 21.1 0.2 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CDW56761.1 - 2.6e-07 30.1 4.0 3.7e-07 29.6 0.4 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CDW56761.1 - 7.8e-05 22.1 6.5 0.025 13.8 0.3 3.2 3 0 0 3 3 3 2 FAD binding domain HI0933_like PF03486.14 CDW56761.1 - 0.0001 21.2 7.3 0.0021 16.9 0.8 3.7 3 1 2 5 5 5 2 HI0933-like protein AlaDh_PNT_C PF01262.21 CDW56761.1 - 0.0001 21.6 3.1 0.033 13.5 0.2 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 CDW56761.1 - 0.0026 17.0 1.7 0.24 10.5 0.1 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CDW56761.1 - 0.0035 16.6 1.5 0.0044 16.3 0.2 1.8 2 0 0 2 2 2 1 Thi4 family 2-Hacid_dh_C PF02826.19 CDW56761.1 - 0.024 14.0 0.5 0.45 9.8 0.1 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DAO PF01266.24 CDW56761.1 - 0.46 10.0 12.4 0.43 10.1 0.6 3.4 4 0 0 4 4 4 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 CDW56761.1 - 1.3 8.6 7.0 13 5.3 0.5 3.0 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 CDW56761.1 - 1.4 7.9 4.8 4.8 6.1 0.4 3.0 3 0 0 3 3 3 0 Lycopene cyclase protein Ank_2 PF12796.7 CDW56762.1 - 3.6e-85 280.6 8.5 4e-13 49.8 0.2 7.5 2 2 5 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW56762.1 - 2.7e-67 214.7 4.7 3.9e-05 23.7 0.0 14.5 14 0 0 14 14 14 12 Ankyrin repeat Ank_4 PF13637.6 CDW56762.1 - 3.3e-62 206.1 14.1 2.9e-11 43.7 0.1 10.4 5 3 7 12 12 12 10 Ankyrin repeats (many copies) Ank PF00023.30 CDW56762.1 - 1.1e-54 180.5 20.4 1.2e-05 25.5 0.0 14.2 14 0 0 14 14 14 11 Ankyrin repeat Ank_5 PF13857.6 CDW56762.1 - 1.3e-47 159.3 22.1 4.2e-09 36.5 0.2 11.8 3 3 10 13 13 13 12 Ankyrin repeats (many copies) DBD_Tnp_Hermes PF10683.9 CDW56762.1 - 0.0031 17.2 0.0 2.8 7.7 0.0 4.2 5 0 0 5 5 5 1 Hermes transposase DNA-binding domain Vps51 PF08700.11 CDW56762.1 - 0.06 13.4 0.2 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 Vps51/Vps67 S36_mt PF10937.8 CDW56762.1 - 0.13 13.9 2.0 8.3 8.0 0.2 2.9 3 0 0 3 3 3 0 Ribosomal protein S36, mitochondrial WHEP-TRS PF00458.20 CDW56762.1 - 0.13 12.4 1.0 0.32 11.2 1.0 1.6 1 0 0 1 1 1 0 WHEP-TRS domain APS_kinase PF01583.20 CDW56764.1 - 2.3e-67 225.8 0.0 3.6e-67 225.2 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.17 CDW56764.1 - 1.4e-65 220.8 0.0 2e-65 220.2 0.0 1.3 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 CDW56764.1 - 1.3e-45 155.0 0.0 2.1e-45 154.2 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 CDW56764.1 - 1e-05 25.8 0.0 2.9e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CDW56764.1 - 0.0028 18.2 0.0 0.0065 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 CDW56764.1 - 0.014 15.1 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family CbiA PF01656.23 CDW56764.1 - 0.047 13.8 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_29 PF13555.6 CDW56764.1 - 0.077 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain HIGH_NTase1 PF05636.11 CDW56764.1 - 0.24 10.6 0.1 2.2 7.4 0.1 2.2 2 0 0 2 2 2 0 HIGH Nucleotidyl Transferase MFS_1 PF07690.16 CDW56765.1 - 9.5e-21 74.1 39.1 9.5e-21 74.1 39.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2892 PF11127.8 CDW56765.1 - 2.3 8.3 0.0 2.3 8.3 0.0 4.9 5 1 1 6 6 6 0 Protein of unknown function (DUF2892) Cystatin PF00031.21 CDW56767.1 - 0.13 12.6 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Cystatin domain 7tm_1 PF00001.21 CDW56768.1 - 2.9e-14 53.0 26.7 4.6e-14 52.4 26.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 CDW56768.1 - 6.9e-08 32.2 23.3 6.9e-08 32.2 23.3 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 CDW56768.1 - 1.4e-05 24.8 24.8 1.9e-05 24.4 24.4 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 CDW56768.1 - 0.0019 17.7 27.5 0.0033 16.8 27.5 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF2537 PF10801.8 CDW56768.1 - 4.1 7.7 10.2 2.2 8.6 1.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2537) Ras PF00071.22 CDW56769.1 - 1.6e-39 135.1 0.2 1.9e-39 134.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW56769.1 - 3.6e-22 78.8 0.1 5.2e-22 78.3 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW56769.1 - 7.1e-14 51.6 0.1 9.4e-14 51.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW56769.1 - 2.1e-06 27.3 0.1 2.6e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 CDW56769.1 - 0.00039 19.7 0.4 0.47 9.6 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit ATPase PF06745.13 CDW56769.1 - 0.0026 17.1 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 KaiC PduV-EutP PF10662.9 CDW56769.1 - 0.0057 16.4 0.0 0.016 14.9 0.0 1.9 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 CDW56769.1 - 0.0064 16.8 0.0 0.33 11.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDW56769.1 - 0.0077 16.2 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 NACHT domain SRPRB PF09439.10 CDW56769.1 - 0.012 15.1 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 CDW56769.1 - 0.017 14.6 0.0 0.04 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Efg1 PF10153.9 CDW56769.1 - 0.022 15.1 0.9 0.039 14.3 0.9 1.3 1 0 0 1 1 1 0 rRNA-processing protein Efg1 AAA_24 PF13479.6 CDW56769.1 - 0.026 14.2 0.1 0.059 13.1 0.0 1.7 1 1 1 2 2 2 0 AAA domain Pox_A32 PF04665.12 CDW56769.1 - 0.028 13.9 0.1 0.1 12.1 0.0 1.9 1 1 2 3 3 3 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 CDW56769.1 - 0.032 14.1 0.0 9.1 6.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase zf-C3HC4_3 PF13920.6 CDW56771.1 - 1.1e-07 31.6 11.2 1.1e-07 31.6 11.2 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW56771.1 - 2e-07 30.7 15.4 2e-07 30.7 15.4 2.6 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW56771.1 - 2.2e-06 27.9 13.6 2.2e-06 27.9 13.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 CDW56771.1 - 2.3e-05 24.3 14.0 2.3e-05 24.3 14.0 2.3 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDW56771.1 - 3.2e-05 23.7 14.7 3.2e-05 23.7 14.7 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW56771.1 - 3.2e-05 23.9 12.9 3.2e-05 23.9 12.9 2.4 2 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CDW56771.1 - 0.00015 21.5 11.0 0.00015 21.5 11.0 2.5 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 PhnA_Zn_Ribbon PF08274.12 CDW56771.1 - 0.014 15.3 8.1 0.16 11.9 0.3 4.2 2 1 0 3 3 3 0 PhnA Zinc-Ribbon zf-RING_11 PF17123.5 CDW56771.1 - 0.61 9.9 14.3 0.078 12.7 3.5 2.9 2 0 0 2 2 2 0 RING-like zinc finger Zn_Tnp_IS91 PF14319.6 CDW56771.1 - 3.1 7.9 19.7 1.5 8.9 2.5 2.9 2 1 0 2 2 2 0 Transposase zinc-binding domain Piezo_RRas_bdg PF12166.8 CDW56772.1 - 2.6e-101 340.0 0.0 1e-99 334.8 0.0 2.5 1 1 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain PIEZO PF15917.5 CDW56772.1 - 1.9e-40 138.8 14.8 1.9e-34 119.1 6.0 2.8 1 1 1 2 2 2 2 Piezo Spectrin PF00435.21 CDW56773.1 - 3.3e-84 278.2 270.4 2.1e-13 50.7 1.6 37.6 33 8 5 39 39 36 20 Spectrin repeat Plectin PF00681.20 CDW56773.1 - 3.1e-75 247.8 5.8 0.0038 17.1 0.0 31.8 27 8 8 35 35 35 15 Plectin repeat CH PF00307.31 CDW56773.1 - 1.4e-39 134.6 2.8 9.6e-23 80.4 0.0 5.3 4 1 1 5 5 5 3 Calponin homology (CH) domain GAS2 PF02187.17 CDW56773.1 - 1.5e-27 95.4 1.0 4.9e-27 93.8 1.0 2.0 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain SH3_10 PF17902.1 CDW56773.1 - 1.3e-15 57.2 0.1 3.7e-15 55.7 0.1 1.9 1 0 0 1 1 1 1 SH3 domain CAMSAP_CH PF11971.8 CDW56773.1 - 1.4e-10 40.8 0.2 9.7e-08 31.7 0.0 3.6 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_6 PF13405.6 CDW56773.1 - 4.5e-08 32.4 1.1 0.034 14.1 0.0 4.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 CDW56773.1 - 2.9e-06 26.4 3.3 0.058 13.0 0.6 3.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDW56773.1 - 5.3e-05 23.0 2.8 0.00042 20.1 1.3 3.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 CDW56773.1 - 0.00011 22.5 2.8 0.00011 22.5 2.8 5.3 4 1 1 5 5 4 2 EF-hand domain pair EF-hand_5 PF13202.6 CDW56773.1 - 1.1 8.9 4.5 6.2 6.5 0.6 3.5 3 0 0 3 3 3 0 EF hand Med29 PF11568.8 CDW56773.1 - 1.4 9.1 12.2 0.93 9.7 0.4 4.8 4 0 0 4 4 4 0 Mediator complex subunit 29 LSM PF01423.22 CDW56774.1 - 5e-19 67.8 0.9 6.8e-19 67.3 0.9 1.2 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.8 CDW56774.1 - 0.057 13.3 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) Hfq PF17209.3 CDW56774.1 - 0.058 13.0 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Hfq protein SM-ATX PF14438.6 CDW56774.1 - 0.13 12.4 0.1 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain HSP20 PF00011.21 CDW56775.1 - 2e-19 69.6 0.1 2e-19 69.6 0.1 1.4 2 0 0 2 2 2 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW56775.1 - 0.012 15.1 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Patatin PF01734.22 CDW56776.1 - 2e-23 83.7 0.0 3.4e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase LRR_6 PF13516.6 CDW56777.1 - 6.7e-10 38.2 7.1 0.00013 21.8 0.0 5.4 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 CDW56777.1 - 3.3e-05 23.8 5.3 0.21 12.3 0.1 4.9 5 0 0 5 5 5 2 Leucine Rich Repeat LRR_4 PF12799.7 CDW56777.1 - 5e-05 23.6 12.5 0.0028 18.0 1.2 4.5 2 1 5 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDW56777.1 - 0.00019 21.1 5.8 0.15 11.9 1.9 4.1 2 2 1 3 3 3 3 Leucine rich repeat DLIC PF05783.11 CDW56778.1 - 4.6e-110 368.7 0.9 6.2e-106 355.0 0.2 2.8 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) ABC_tran PF00005.27 CDW56778.1 - 0.017 15.7 0.0 0.044 14.3 0.0 1.8 2 0 0 2 2 2 0 ABC transporter GTP_EFTU PF00009.27 CDW56778.1 - 0.029 13.9 0.1 0.71 9.4 0.0 2.5 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDW56778.1 - 0.044 14.2 0.0 0.49 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 CDW56778.1 - 0.088 13.0 1.1 0.28 11.4 0.0 2.4 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 CDW56778.1 - 0.13 11.8 0.0 0.91 9.0 0.0 2.2 3 0 0 3 3 3 0 Ferrous iron transport protein B Cytochrom_C1 PF02167.15 CDW56779.1 - 4e-88 294.8 0.0 4.5e-88 294.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 CDW56779.1 - 0.00074 19.8 0.1 0.0015 18.8 0.1 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 CDW56779.1 - 0.002 19.3 0.1 0.0061 17.7 0.0 1.9 2 0 0 2 2 2 1 Cytochrome c Sugar_tr PF00083.24 CDW56780.1 - 4.5e-28 98.3 15.0 6.7e-28 97.7 15.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW56780.1 - 1.9e-15 56.6 43.1 7.1e-15 54.8 23.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CDW56780.1 - 0.00019 20.2 5.9 0.00019 20.2 5.9 2.4 2 0 0 2 2 2 1 MFS/sugar transport protein WD40 PF00400.32 CDW56781.1 - 1.5e-17 63.7 9.8 6e-05 23.7 0.2 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56781.1 - 0.00011 22.4 0.1 0.031 14.5 0.0 3.8 2 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Mito_fiss_Elm1 PF06258.11 CDW56781.1 - 0.081 12.0 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission ELM1 Lactonase PF10282.9 CDW56781.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller AMP-binding PF00501.28 CDW56782.1 - 6.4e-20 71.1 0.1 1.5e-11 43.6 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme Sec62 PF03839.16 CDW56783.1 - 2.4e-48 164.5 8.7 1.5e-47 161.9 6.1 2.0 1 1 1 2 2 2 2 Translocation protein Sec62 Sensor PF13796.6 CDW56783.1 - 0.0004 20.5 0.3 0.00055 20.0 0.3 1.1 1 0 0 1 1 1 1 Putative sensor DEP PF00610.21 CDW56783.1 - 0.0057 16.7 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF3481 PF11980.8 CDW56783.1 - 0.13 12.0 1.1 0.24 11.1 1.1 1.4 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein DUF4306 PF14154.6 CDW56783.1 - 0.15 12.3 0.0 0.61 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4306) adh_short PF00106.25 CDW56784.1 - 4.9e-27 94.7 0.0 2.6e-26 92.3 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW56784.1 - 9.7e-15 54.8 0.0 3.8e-14 52.8 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW56784.1 - 7.3e-07 29.3 0.0 1.5e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CDW56784.1 - 0.15 11.9 0.0 0.18 11.7 0.0 1.4 1 1 0 1 1 1 0 NAD(P)H-binding MFS_1 PF07690.16 CDW56785.1 - 8.1e-31 107.2 30.7 1.3e-30 106.6 25.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CDW56785.1 - 0.00013 21.4 5.3 0.00013 21.4 5.3 2.5 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Wzy_C PF04932.15 CDW56785.1 - 2.8 7.6 6.9 11 5.6 0.3 3.1 3 0 0 3 3 3 0 O-Antigen ligase Helicase_C_2 PF13307.6 CDW56786.1 - 4.5e-47 160.4 0.0 2.7e-46 157.8 0.0 2.0 1 1 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CDW56786.1 - 5.1e-14 52.3 0.2 9.5e-14 51.4 0.2 1.4 1 0 0 1 1 1 1 DEAD_2 DEAD_2 PF06733.15 CDW56787.1 - 3.7e-08 33.2 1.1 3.6e-06 26.7 0.2 2.8 1 1 1 2 2 2 2 DEAD_2 DEAD PF00270.29 CDW56787.1 - 0.0047 16.7 0.0 0.011 15.5 0.0 1.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDW56787.1 - 0.1 12.6 0.0 0.13 12.3 0.0 1.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Gpi16 PF04113.14 CDW56788.1 - 9.8e-111 370.9 0.0 6.4e-108 361.6 0.0 2.0 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component ANAPC4_WD40 PF12894.7 CDW56789.1 - 2.4e-09 37.4 7.1 0.017 15.4 0.1 6.3 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW56789.1 - 2.1e-05 24.5 2.3 0.02 14.8 1.3 3.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A TPR_7 PF13176.6 CDW56789.1 - 0.00087 19.2 1.4 0.065 13.3 0.1 3.7 2 1 0 2 2 2 1 Tetratricopeptide repeat WD40 PF00400.32 CDW56789.1 - 0.0013 19.5 0.6 23 6.1 0.0 4.4 3 1 1 4 4 3 0 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 CDW56789.1 - 0.0055 15.8 4.5 0.032 13.3 0.0 3.6 4 1 0 4 4 4 1 Coatomer WD associated region Clathrin PF00637.20 CDW56789.1 - 0.0055 16.6 6.2 0.17 11.8 0.2 4.1 1 1 3 4 4 4 2 Region in Clathrin and VPS TPR_2 PF07719.17 CDW56789.1 - 0.0063 16.5 2.6 0.85 9.9 0.8 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDW56789.1 - 0.037 14.3 1.5 2.6 8.4 0.1 3.3 1 1 1 2 2 2 0 Tetratricopeptide repeat WD40_like PF17005.5 CDW56789.1 - 0.06 12.7 0.4 0.73 9.1 0.1 2.5 2 1 0 2 2 2 0 WD40-like domain TPR_1 PF00515.28 CDW56789.1 - 0.44 10.5 3.8 18 5.3 0.7 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat zinc-ribbons_6 PF07191.12 CDW56789.1 - 0.72 9.9 7.6 16 5.6 0.5 2.6 1 1 1 2 2 2 0 zinc-ribbons TackOD1 PF18551.1 CDW56789.1 - 0.75 9.4 6.7 5.7 6.6 6.7 2.4 1 1 0 1 1 1 0 Thaumarchaeal output domain 1 PHD PF00628.29 CDW56789.1 - 1.1 9.3 7.0 8.3 6.4 7.5 2.3 1 1 1 2 2 2 0 PHD-finger DZR PF12773.7 CDW56789.1 - 2.8 8.0 10.6 1.7e+02 2.4 10.6 2.5 1 1 0 1 1 1 0 Double zinc ribbon A2L_zn_ribbon PF08792.10 CDW56789.1 - 7.2 6.4 6.9 10 6.0 0.5 4.1 4 0 0 4 4 4 0 A2L zinc ribbon domain Miga PF10265.9 CDW56790.1 - 1.5e-57 195.8 0.5 1.5e-57 195.8 0.5 2.4 2 1 0 2 2 2 1 Mitoguardin SURF6 PF04935.12 CDW56790.1 - 1.8e-32 112.8 39.0 3.5e-32 111.8 39.0 1.4 1 0 0 1 1 1 1 Surfeit locus protein 6 Ras PF00071.22 CDW56791.1 - 2.2e-15 56.6 0.0 2.2e-07 30.6 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CDW56791.1 - 3.5e-11 43.4 0.0 3.3e-09 37.0 0.0 2.1 1 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW56791.1 - 3e-06 26.8 0.0 0.00098 18.6 0.0 2.2 1 1 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW56791.1 - 0.00011 22.3 0.0 0.00015 21.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 CDW56791.1 - 0.018 14.5 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 CDW56791.1 - 0.027 13.9 0.0 0.045 13.2 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DLIC PF05783.11 CDW56791.1 - 0.041 12.7 0.3 0.22 10.3 0.3 2.0 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_14 PF13173.6 CDW56791.1 - 0.072 13.1 0.0 0.11 12.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain AMPK1_CBM PF16561.5 CDW56792.1 - 1.4e-29 102.1 0.2 2.3e-29 101.5 0.2 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 CDW56792.1 - 1.4e-27 95.8 4.9 2.4e-27 95.0 4.9 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM53 PF16760.5 CDW56792.1 - 0.073 13.7 0.1 0.15 12.7 0.1 1.4 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) Plexin_cytopl PF08337.12 CDW56793.1 - 4e-210 699.2 0.3 2.1e-209 696.8 0.3 1.9 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain Sema PF01403.19 CDW56793.1 - 3e-40 138.4 0.0 4.7e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 Sema domain TIG PF01833.24 CDW56793.1 - 4.2e-33 113.3 11.8 1.3e-12 47.6 0.4 5.5 5 0 0 5 5 5 4 IPT/TIG domain TIG_2 PF18020.1 CDW56793.1 - 7.5e-24 84.2 0.0 2.1e-20 73.1 0.0 2.8 2 0 0 2 2 2 2 TIG domain found in plexin TIG_plexin PF17960.1 CDW56793.1 - 2e-21 75.8 2.0 8.8e-19 67.3 0.1 4.3 5 0 0 5 5 4 1 TIG domain PSI PF01437.25 CDW56793.1 - 5.7e-18 65.2 52.1 2.6e-07 31.1 14.8 3.6 3 0 0 3 3 3 3 Plexin repeat Vpu PF00558.19 CDW56793.1 - 0.023 14.5 0.6 0.052 13.3 0.6 1.5 1 0 0 1 1 1 0 Vpu protein 60KD_IMP PF02096.20 CDW56793.1 - 0.03 14.2 0.1 0.063 13.2 0.1 1.4 1 0 0 1 1 1 0 60Kd inner membrane protein Adeno_E3_CR2 PF02439.15 CDW56793.1 - 0.047 13.4 0.2 0.1 12.4 0.2 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Neuroparsin PF07327.11 CDW56793.1 - 0.055 13.9 3.6 0.12 12.8 1.7 2.6 2 0 0 2 2 1 0 Neuroparsin DnaI_N PF07319.11 CDW56793.1 - 0.081 13.6 0.2 0.29 11.8 0.2 1.9 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus LapA_dom PF06305.11 CDW56793.1 - 0.14 12.0 0.6 0.31 10.9 0.6 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EMC3_TMCO1 PF01956.16 CDW56793.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like PSI_integrin PF17205.3 CDW56793.1 - 6.2 6.6 51.3 2.7 7.8 13.5 3.7 3 0 0 3 3 3 0 Integrin plexin domain WD40 PF00400.32 CDW56794.1 - 0.002 18.9 7.5 0.46 11.5 0.1 4.1 3 1 0 3 3 3 2 WD domain, G-beta repeat Herpes_gI PF01688.17 CDW56795.1 - 0.67 9.9 2.9 0.77 9.7 0.3 2.5 3 0 0 3 3 3 0 Alphaherpesvirus glycoprotein I EF-hand_10 PF14788.6 CDW56797.1 - 3.4e-05 23.6 0.3 15 5.5 0.0 5.7 6 0 0 6 6 6 3 EF hand TgMIC1 PF11476.8 CDW56797.1 - 0.89 9.3 3.2 31 4.3 0.0 4.6 6 1 0 6 6 6 0 Toxoplasma gondii micronemal protein 1 TgMIC1 Trypsin PF00089.26 CDW56798.1 - 1e-81 273.9 0.5 1.9e-43 148.9 0.4 2.6 3 0 0 3 3 3 2 Trypsin Pkinase PF00069.25 CDW56798.1 - 2.5e-22 79.5 0.0 3.8e-22 78.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Trypsin_2 PF13365.6 CDW56798.1 - 1.3e-13 52.1 0.0 1.9e-05 25.6 0.0 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain Pkinase_Tyr PF07714.17 CDW56798.1 - 9.2e-12 44.8 0.0 1.6e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1986 PF09342.11 CDW56798.1 - 0.013 15.9 0.0 2.1 8.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1986) Pkinase_fungal PF17667.1 CDW56798.1 - 0.033 13.0 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase DUF4507 PF14964.6 CDW56799.1 - 3.4e-28 98.6 0.2 5e-28 98.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) SelP_C PF04593.14 CDW56799.1 - 0.26 11.3 3.0 2.8 7.9 3.3 2.1 1 1 1 2 2 2 0 Selenoprotein P, C terminal region MutS_V PF00488.21 CDW56800.1 - 1.1e-76 257.0 0.0 3.3e-76 255.5 0.0 1.8 1 0 0 1 1 1 1 MutS domain V MutS_IV PF05190.18 CDW56800.1 - 9.4e-12 45.1 1.5 2.8e-11 43.6 1.5 1.9 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 CDW56800.1 - 1.5e-08 35.0 0.2 4.5e-08 33.5 0.1 2.0 2 0 0 2 2 2 1 MutS domain II MutS_III PF05192.18 CDW56800.1 - 3.4e-06 27.4 0.9 8e-06 26.2 0.1 2.1 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 CDW56800.1 - 2.9e-05 24.3 0.0 8.8e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 MutS domain I DUF3445 PF11927.8 CDW56800.1 - 0.019 14.6 0.1 0.05 13.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3445) DUF573 PF04504.14 CDW56800.1 - 0.063 13.9 2.0 0.35 11.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF573 CDO_I PF05995.12 CDW56800.1 - 0.067 12.5 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 Cysteine dioxygenase type I F-box-like PF12937.7 CDW56802.1 - 0.097 12.6 0.2 0.29 11.1 0.2 1.9 1 0 0 1 1 1 0 F-box-like DUF2019 PF09450.10 CDW56802.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2019) TSP_1 PF00090.19 CDW56803.1 - 1.5e-83 274.8 197.0 1.6e-12 47.5 11.2 12.9 12 0 0 12 12 12 11 Thrombospondin type 1 domain Pro-NT_NN PF07421.11 CDW56804.1 - 0.092 13.0 0.3 0.11 12.8 0.3 1.1 1 0 0 1 1 1 0 Neurotensin/neuromedin N precursor MNSV_P7B PF06692.11 CDW56804.1 - 2.1 8.4 5.3 4.7 7.3 2.8 2.1 1 1 1 2 2 2 0 Melon necrotic spot virus P7B protein UDPGT PF00201.18 CDW56805.1 - 1.3e-72 245.2 0.3 1.2e-71 242.1 0.3 1.9 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW56805.1 - 9.2e-05 22.5 0.0 0.00016 21.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.6 CDW56805.1 - 0.0025 18.2 0.0 0.019 15.4 0.0 2.2 1 1 1 2 2 2 1 Glycosyl transferases group 1 Pkinase PF00069.25 CDW56806.1 - 7.5e-74 248.4 0.0 1e-73 248.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56806.1 - 4.7e-31 108.0 0.0 7.9e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW56806.1 - 4.1e-07 29.3 0.0 6.7e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW56806.1 - 0.00052 19.4 0.0 0.0024 17.2 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CDW56806.1 - 0.0034 16.8 0.1 0.0066 15.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 CDW56806.1 - 0.35 9.8 1.8 1.4 7.8 1.3 1.9 1 1 1 2 2 2 0 Poxvirus serine/threonine protein kinase Rad10 PF03834.14 CDW56807.1 - 2.3e-43 146.8 0.0 4e-43 146.1 0.0 1.4 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 CDW56807.1 - 4.4e-06 27.2 0.2 1.3e-05 25.7 0.1 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 CDW56807.1 - 0.0032 17.5 0.0 0.011 15.9 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH PF00633.23 CDW56807.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF1365 PF07103.11 CDW56807.1 - 0.15 11.7 0.0 0.27 10.8 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1365) XendoU PF09412.10 CDW56808.1 - 2.6e-192 636.6 1.3 2.2e-65 220.5 0.1 4.1 3 1 1 4 4 4 4 Endoribonuclease XendoU EndoU_bacteria PF14436.6 CDW56808.1 - 6.5e-10 39.4 1.3 0.32 11.4 0.0 4.8 5 0 0 5 5 5 3 Bacterial EndoU nuclease NMT_C PF02799.15 CDW56808.1 - 0.0031 17.1 0.7 0.27 10.8 0.1 2.7 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Adeno_E4 PF05385.11 CDW56808.1 - 0.028 14.5 0.8 17 5.6 0.0 3.2 3 0 0 3 3 3 0 Mastadenovirus early E4 13 kDa protein HAT PF02184.16 CDW56808.1 - 0.094 12.7 4.8 20 5.2 0.0 4.0 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat OSCP PF00213.18 CDW56808.1 - 0.36 10.9 1.3 18 5.4 0.2 2.9 3 0 0 3 3 3 0 ATP synthase delta (OSCP) subunit Alpha-amylase PF00128.24 CDW56809.1 - 2.4e-19 70.1 0.7 3.7e-19 69.5 0.0 1.7 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 CDW56809.1 - 5.8e-09 36.3 0.3 2.9e-08 34.1 0.0 2.4 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain XendoU PF09412.10 CDW56810.1 - 6.6e-61 205.8 4.1 8.2e-61 205.5 4.1 1.1 1 0 0 1 1 1 1 Endoribonuclease XendoU Kinase-PolyVal PF18762.1 CDW56810.1 - 0.058 13.4 1.3 0.1 12.5 0.5 1.8 2 0 0 2 2 2 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins HisKA_4TM PF16926.5 CDW56811.1 - 0.036 13.6 0.6 1.7 8.2 0.3 2.4 2 0 0 2 2 2 0 Archaeal 4TM region of histidine kinase zf-HIT PF04438.16 CDW56812.1 - 3.2e-11 42.9 8.8 4.3e-11 42.5 8.8 1.2 1 0 0 1 1 1 1 HIT zinc finger AIP3 PF03915.13 CDW56813.1 - 1.5e-14 53.9 0.1 1.7e-14 53.8 0.1 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 zf-H2C2_2 PF13465.6 CDW56817.1 - 1.1e-05 25.7 159.5 0.043 14.3 1.8 20.1 21 0 0 21 21 21 10 Zinc-finger double domain zf-H2C2_5 PF13909.6 CDW56817.1 - 0.00077 19.2 3.2 0.00077 19.2 3.2 17.3 19 0 0 19 19 19 6 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 CDW56817.1 - 0.0023 18.3 0.0 0.0023 18.3 0.0 23.9 26 1 0 26 26 26 3 Zinc finger, C2H2 type PRP21_like_P PF12230.8 CDW56817.1 - 0.0031 17.4 8.1 0.48 10.3 1.0 4.5 5 0 0 5 5 5 1 Pre-mRNA splicing factor PRP21 like protein Cytochrome_CBB3 PF13442.6 CDW56817.1 - 0.01 16.2 0.1 0.028 14.7 0.1 1.8 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III zf-RING_7 PF02591.15 CDW56817.1 - 0.44 10.8 4.5 2.1 8.6 0.1 4.6 3 0 0 3 3 3 0 C4-type zinc ribbon domain Pannexin_like PF12534.8 CDW56817.1 - 0.5 9.4 4.6 1.8 7.6 4.6 2.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 ECH_2 PF16113.5 CDW56818.1 - 7.6e-123 410.3 0.0 9e-123 410.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CDW56818.1 - 5.7e-33 114.3 0.2 4.5e-31 108.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF4600 PF15372.6 CDW56818.1 - 0.27 11.6 2.0 0.27 11.7 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) EamA PF00892.20 CDW56819.1 - 5.1e-09 36.4 24.9 7.7e-09 35.8 1.4 3.4 3 1 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 CDW56819.1 - 8.7e-09 35.0 1.5 1.2e-08 34.5 1.5 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter SLC35F PF06027.12 CDW56819.1 - 9.2e-08 31.9 5.9 9.2e-08 31.9 5.9 1.6 2 0 0 2 2 2 1 Solute carrier family 35 CRT-like PF08627.10 CDW56819.1 - 6.5e-07 28.6 6.1 6.5e-07 28.6 6.1 2.1 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 CDW56819.1 - 9.3e-05 21.9 1.5 9.3e-05 21.9 1.5 1.9 1 1 0 1 1 1 1 Triose-phosphate Transporter family Peptidase_M10 PF00413.24 CDW56822.1 - 3.1e-41 140.9 0.0 4.6e-41 140.3 0.0 1.2 1 0 0 1 1 1 1 Matrixin Peptidase_M54 PF07998.11 CDW56822.1 - 0.002 18.2 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M54 Reprolysin_4 PF13583.6 CDW56822.1 - 0.003 17.2 0.0 0.0069 16.0 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 CDW56822.1 - 0.0041 16.1 0.0 0.0073 15.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M66 Metallopep PF12044.8 CDW56822.1 - 0.0062 15.2 0.2 0.013 14.2 0.2 1.6 1 1 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.6 CDW56822.1 - 0.0066 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 CDW56822.1 - 0.007 16.9 0.4 0.025 15.1 0.0 2.1 3 0 0 3 3 3 1 Metallo-peptidase family M12B Reprolysin-like DUF45 PF01863.17 CDW56822.1 - 0.036 14.1 0.3 0.45 10.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF45 DUF4953 PF16313.5 CDW56822.1 - 0.051 12.8 0.6 0.1 11.8 0.1 1.7 2 0 0 2 2 2 0 Met-zincin PG_binding_1 PF01471.18 CDW56822.1 - 0.15 12.3 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Putative peptidoglycan binding domain KH_1 PF00013.29 CDW56823.1 - 8.7e-06 25.5 0.2 9.6e-05 22.1 0.2 2.4 2 0 0 2 2 2 1 KH domain JAB PF01398.21 CDW56824.1 - 1e-09 38.4 0.0 2.1e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ras PF00071.22 CDW56825.1 - 1.1e-60 204.0 0.2 1.3e-60 203.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW56825.1 - 7e-37 126.3 0.1 1.1e-36 125.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW56825.1 - 4.7e-16 58.7 0.1 5.9e-16 58.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW56825.1 - 7e-08 32.2 0.3 3.8e-07 29.9 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDW56825.1 - 3.4e-07 29.9 0.1 4.4e-07 29.5 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW56825.1 - 3.1e-06 27.2 0.1 4e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW56825.1 - 0.00012 22.0 1.1 0.027 14.4 0.0 2.1 1 1 1 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CDW56825.1 - 0.0019 18.6 0.0 0.0047 17.3 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.18 CDW56825.1 - 0.0038 16.8 0.4 0.024 14.2 0.4 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_22 PF13401.6 CDW56825.1 - 0.015 15.6 0.0 0.031 14.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDW56825.1 - 0.015 15.0 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRPRB PF09439.10 CDW56825.1 - 0.017 14.6 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 CDW56825.1 - 0.025 14.3 0.1 0.046 13.4 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDW56825.1 - 0.031 14.3 0.0 0.1 12.6 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) MMR_HSR1_Xtn PF16897.5 CDW56825.1 - 0.031 14.3 0.3 0.042 13.9 0.3 1.3 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TniB PF05621.11 CDW56825.1 - 0.037 13.4 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_7 PF12775.7 CDW56825.1 - 0.037 13.5 0.0 0.15 11.5 0.0 1.8 1 1 1 2 2 2 0 P-loop containing dynein motor region PduV-EutP PF10662.9 CDW56825.1 - 0.047 13.4 0.1 0.18 11.5 0.1 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 CDW56825.1 - 0.076 12.1 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain ABC_tran PF00005.27 CDW56825.1 - 0.12 12.9 0.3 0.16 12.5 0.3 1.5 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 CDW56825.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.6 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 CDW56825.1 - 0.13 12.6 0.0 0.88 10.0 0.0 2.1 1 1 0 1 1 1 0 RNA helicase zf-C2H2 PF00096.26 CDW56826.1 - 3.1e-16 58.8 19.8 2.2e-05 24.6 0.2 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW56826.1 - 1.7e-13 50.3 7.2 2.1e-08 34.2 0.6 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW56826.1 - 4.8e-11 42.5 18.1 0.00089 19.9 3.1 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CDW56826.1 - 0.0046 16.7 0.4 0.0046 16.7 0.4 3.4 3 1 0 3 3 2 1 C2H2-type zinc-finger domain FOXP-CC PF16159.5 CDW56826.1 - 0.021 15.5 5.6 0.21 12.2 1.9 2.8 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 CDW56826.1 - 0.047 13.8 4.5 2.5 8.2 0.4 2.4 2 1 0 2 2 2 0 Aberrant zinc-finger zf-C2H2_8 PF15909.5 CDW56826.1 - 0.11 12.9 7.8 0.28 11.5 2.9 2.7 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-RING_11 PF17123.5 CDW56826.1 - 0.16 11.7 0.0 0.16 11.7 0.0 2.4 2 0 0 2 2 2 0 RING-like zinc finger Sina PF03145.16 CDW56826.1 - 0.17 11.8 6.1 0.26 11.2 6.1 1.3 1 0 0 1 1 1 0 Seven in absentia protein family zf-C2HE PF16278.5 CDW56826.1 - 0.22 12.0 5.9 1.9 9.0 0.1 3.0 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 CDW56826.1 - 1 9.8 7.1 7 7.2 0.4 3.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW56826.1 - 3.3 8.1 8.4 11 6.5 0.7 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Bac_surface_Ag PF01103.23 CDW56827.1 - 5.1e-33 114.9 0.0 6.7e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Surface antigen POTRA PF07244.15 CDW56827.1 - 0.22 12.1 0.0 0.42 11.2 0.0 1.5 1 0 0 1 1 1 0 Surface antigen variable number repeat PAN_1 PF00024.26 CDW56828.1 - 8.3e-15 54.5 7.4 0.00039 20.3 0.1 3.4 3 0 0 3 3 3 3 PAN domain DUF1289 PF06945.13 CDW56828.1 - 0.18 11.6 11.9 6.1 6.7 0.2 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1289) SAM_1 PF00536.30 CDW56830.1 - 1.4e-09 38.2 0.1 2.6e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW56830.1 - 5.9e-05 23.1 0.1 9.5e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 CDW56830.1 - 0.00016 21.6 0.0 0.00028 20.8 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Peptidase_C48 PF02902.19 CDW56831.1 - 9.2e-21 74.7 0.2 1.8e-20 73.7 0.2 1.5 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF2184 PF09950.9 CDW56831.1 - 0.084 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2184) PBP PF01161.20 CDW56832.1 - 2.2e-19 70.1 0.1 3.3e-19 69.5 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Rad21_Rec8_N PF04825.13 CDW56835.1 - 1e-38 131.9 0.0 1.3e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Frizzled PF01534.17 CDW56836.1 - 2.1e-100 335.9 22.0 2.7e-100 335.6 22.0 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 CDW56836.1 - 3.6e-29 101.6 5.4 3.6e-29 101.6 5.4 2.4 3 0 0 3 3 3 1 Fz domain LapA_dom PF06305.11 CDW56836.1 - 1.6 8.6 6.9 1.3 8.8 0.0 3.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain HSP20 PF00011.21 CDW56837.1 - 7.1e-18 64.6 0.0 8.5e-18 64.4 0.0 1.0 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW56837.1 - 5.8e-06 25.8 0.0 7.1e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 HSP20-like domain found in ArsA DUF4845 PF16137.5 CDW56837.1 - 0.063 14.1 0.0 0.13 13.1 0.0 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4845) PDCD9 PF07147.12 CDW56838.1 - 2.3e-61 208.4 0.0 3e-61 208.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S30 (PDCD9) Pkinase PF00069.25 CDW56839.1 - 1.4e-63 214.8 0.0 2e-63 214.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56839.1 - 1.7e-36 125.9 0.0 2e-34 119.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW56839.1 - 1.7e-05 23.8 0.0 2.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 CDW56839.1 - 0.0024 16.9 0.0 0.0033 16.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 CDW56839.1 - 0.0076 15.3 0.1 0.011 14.8 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 CDW56839.1 - 0.046 13.0 0.0 0.078 12.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 CDW56839.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase GARS_A PF01071.19 CDW56840.1 - 9.3e-57 191.9 0.1 1.9e-56 190.9 0.1 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Formyl_trans_N PF00551.19 CDW56840.1 - 4.1e-48 163.5 0.3 1.8e-46 158.2 0.3 2.3 1 1 0 1 1 1 1 Formyl transferase AIRS_C PF02769.22 CDW56840.1 - 1.2e-31 110.0 0.0 5.7e-31 107.8 0.0 2.1 2 0 0 2 2 2 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 CDW56840.1 - 1.1e-26 93.4 0.1 1.6e-25 89.7 0.0 2.7 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 CDW56840.1 - 3.9e-24 84.7 0.1 8.3e-24 83.7 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 CDW56840.1 - 9.5e-15 55.0 0.2 2.8e-14 53.5 0.2 1.8 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain ATP-grasp_3 PF02655.14 CDW56840.1 - 0.0075 16.3 0.2 0.079 13.0 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain MurB_C PF02873.16 CDW56840.1 - 0.097 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain DUF4199 PF13858.6 CDW56841.1 - 0.0019 18.6 8.1 0.0019 18.6 8.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF4199) LapA_dom PF06305.11 CDW56841.1 - 0.066 13.0 0.1 0.066 13.0 0.1 3.0 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain DUF948 PF06103.11 CDW56841.1 - 0.12 12.7 1.2 0.35 11.1 0.1 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CBP_BcsF PF11120.8 CDW56841.1 - 0.22 11.7 2.8 0.55 10.4 1.1 2.3 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF ICMT PF04140.14 CDW56841.1 - 0.46 10.9 0.2 0.46 10.9 0.2 3.1 3 1 0 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family CoA_binding_3 PF13727.6 CDW56841.1 - 1.3 9.0 9.6 4.3 7.3 3.5 2.5 1 1 1 2 2 2 0 CoA-binding domain DHHC PF01529.20 CDW56841.1 - 2.6 8.2 9.9 0.71 10.0 5.9 2.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF4491 PF14898.6 CDW56841.1 - 3.3 8.2 12.3 0.52 10.8 2.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4491) I-set PF07679.16 CDW56842.1 - 2e-22 79.1 0.0 2.9e-12 46.5 0.0 2.8 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW56842.1 - 4.7e-19 68.8 0.2 3.1e-09 37.3 0.0 3.8 2 1 2 4 4 4 2 Immunoglobulin domain Ig_2 PF13895.6 CDW56842.1 - 2.4e-12 47.0 0.1 2.9e-05 24.3 0.0 3.4 2 1 2 4 4 4 2 Immunoglobulin domain ig PF00047.25 CDW56842.1 - 2.6e-09 37.1 0.0 7.9e-05 22.8 0.0 3.1 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 CDW56842.1 - 8.4e-09 35.6 1.9 0.0037 17.4 0.0 4.1 2 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.5 CDW56842.1 - 2.9e-05 24.3 0.1 0.0028 17.9 0.0 3.3 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ephrin PF00812.17 CDW56842.1 - 0.024 14.6 0.1 0.044 13.8 0.1 1.5 1 0 0 1 1 1 0 Ephrin GCV_T PF01571.21 CDW56843.1 - 8.3e-11 41.7 0.0 1.3e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Endosulfine PF04667.17 CDW56844.1 - 1.5e-11 44.2 2.3 2.5e-11 43.5 0.9 1.9 2 0 0 2 2 2 1 cAMP-regulated phosphoprotein/endosulfine conserved region KCNQ_channel PF03520.14 CDW56845.1 - 2.2e-16 60.3 0.2 3.4e-16 59.6 0.2 1.3 1 0 0 1 1 1 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.31 CDW56845.1 - 7.8e-12 44.9 13.4 1.3e-11 44.2 13.4 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 CDW56845.1 - 1.5e-09 37.7 5.3 1.5e-09 37.7 5.3 3.1 3 0 0 3 3 3 2 Ion channel Sec62 PF03839.16 CDW56845.1 - 0.00074 19.1 0.8 0.0017 17.9 0.8 1.5 1 0 0 1 1 1 1 Translocation protein Sec62 Lig_chan PF00060.26 CDW56845.1 - 2 8.2 7.4 18 5.2 4.6 2.9 1 1 1 2 2 2 0 Ligand-gated ion channel IKI3 PF04762.12 CDW56846.1 - 5.3e-136 455.0 0.1 1.5e-132 443.6 0.0 2.1 1 1 1 2 2 2 2 IKI3 family Keratin_assoc PF09775.9 CDW56846.1 - 2.4e-24 85.4 4.7 5.8e-24 84.2 4.7 1.6 1 0 0 1 1 1 1 Keratinocyte-associated protein 2 Clathrin PF00637.20 CDW56846.1 - 0.038 13.9 3.1 0.94 9.3 0.0 3.5 3 1 1 4 4 4 0 Region in Clathrin and VPS TPR_7 PF13176.6 CDW56846.1 - 0.075 13.1 0.6 0.59 10.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDW56846.1 - 0.076 13.2 0.0 0.43 10.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-C4 PF00105.18 CDW56847.1 - 2.6e-28 98.3 18.5 6.4e-28 97.0 18.5 1.7 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW56847.1 - 6.6e-27 94.4 0.9 2.3e-26 92.7 0.9 1.8 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Atypical_Card PF18461.1 CDW56847.1 - 0.25 11.6 2.6 15 5.8 0.1 3.3 3 1 1 4 4 4 0 Atypical caspase recruitment domain AAA_12 PF13087.6 CDW56848.1 - 1.7e-57 194.3 0.0 3.6e-57 193.2 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CDW56848.1 - 9.2e-50 169.8 1.2 8.4e-28 97.9 0.2 2.2 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 CDW56848.1 - 1.5e-29 102.1 0.0 2.8e-29 101.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 CDW56848.1 - 2.5e-13 50.2 0.0 1.5e-12 47.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDW56848.1 - 9.5e-11 42.2 0.0 2.7e-10 40.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CDW56848.1 - 3.9e-06 26.8 0.0 0.041 13.6 0.0 3.1 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CDW56848.1 - 2.6e-05 24.3 0.0 6e-05 23.1 0.0 1.6 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 CDW56848.1 - 0.00024 21.0 0.0 0.00073 19.4 0.0 1.8 2 0 0 2 2 2 1 Helicase DUF2075 PF09848.9 CDW56848.1 - 0.0011 18.3 0.0 0.02 14.2 0.0 2.4 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.22 CDW56848.1 - 0.008 15.8 0.0 0.014 15.0 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain UvrD-helicase PF00580.21 CDW56848.1 - 0.024 14.2 0.0 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 CDW56848.1 - 0.034 14.6 0.1 0.096 13.1 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 CDW56848.1 - 0.043 13.2 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_16 PF13191.6 CDW56848.1 - 0.063 13.7 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Hydin_ADK PF17213.3 CDW56848.1 - 0.064 13.5 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain AAA_22 PF13401.6 CDW56848.1 - 0.075 13.3 0.1 0.36 11.1 0.0 2.1 2 1 0 2 2 1 0 AAA domain PhoH PF02562.16 CDW56848.1 - 0.13 11.7 0.0 0.33 10.4 0.0 1.7 1 1 0 1 1 1 0 PhoH-like protein AAA_5 PF07728.14 CDW56848.1 - 0.15 12.0 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 CDW56848.1 - 0.16 11.0 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein HhH-GPD PF00730.25 CDW56849.1 - 1.1e-20 74.1 0.0 1.6e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDW56849.1 - 1e-08 34.6 0.0 4.3e-08 32.6 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 CDW56849.1 - 1.3 9.4 8.3 0.29 11.5 4.7 1.8 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III MDD_C PF18376.1 CDW56850.1 - 5.2e-55 186.1 0.0 7.2e-55 185.6 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 CDW56850.1 - 0.00052 20.2 2.2 0.0016 18.6 2.2 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain Cadherin PF00028.17 CDW56851.1 - 3.9e-09 36.8 0.0 1.5e-06 28.6 0.0 2.6 2 0 0 2 2 2 2 Cadherin domain Pox_polyA_pol_C PF12629.7 CDW56851.1 - 0.021 14.6 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain NICE-3 PF07406.11 CDW56851.1 - 0.37 10.8 1.3 0.72 9.8 1.3 1.4 1 0 0 1 1 1 0 NICE-3 protein Syja_N PF02383.18 CDW56852.1 - 2.2e-69 234.2 0.0 5.6e-69 232.9 0.0 1.6 2 0 0 2 2 2 1 SacI homology domain hSac2 PF12456.8 CDW56852.1 - 1.6e-22 79.4 0.1 4.8e-22 77.8 0.1 1.8 1 0 0 1 1 1 1 Inositol phosphatase Mpv17_PMP22 PF04117.12 CDW56853.1 - 1.6e-14 53.8 0.5 3.1e-14 52.9 0.5 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family Laminin_G_2 PF02210.24 CDW56854.1 - 0.0034 17.9 0.0 0.0039 17.8 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 CDW56854.1 - 0.0098 16.1 0.0 0.011 15.9 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_EGF PF00053.24 CDW56855.1 - 1.3e-123 403.0 371.0 2e-11 43.9 9.4 19.9 19 1 1 20 20 20 19 Laminin EGF domain Laminin_N PF00055.17 CDW56855.1 - 4.7e-69 232.5 0.0 4.7e-69 232.5 0.0 3.6 4 0 0 4 4 1 1 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 CDW56855.1 - 6.6e-60 200.9 0.3 1.3e-29 102.8 0.1 2.5 2 0 0 2 2 2 2 Laminin B (Domain IV) Laminin_G_2 PF02210.24 CDW56855.1 - 1.2e-34 119.6 2.3 3.1e-15 56.9 0.0 3.8 3 1 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 CDW56855.1 - 2.6e-32 111.8 0.2 7.7e-18 65.0 0.0 3.5 3 0 0 3 3 3 3 Laminin G domain Laminin_II PF06009.12 CDW56855.1 - 3.8e-05 23.7 20.5 0.00065 19.7 5.0 4.5 3 2 2 5 5 5 1 Laminin Domain II DUF948 PF06103.11 CDW56855.1 - 0.0099 16.1 12.2 1.8 8.9 0.0 5.0 5 1 1 6 6 6 2 Bacterial protein of unknown function (DUF948) LXG PF04740.12 CDW56855.1 - 1.5 8.5 15.0 0.4 10.4 0.3 3.2 2 1 0 3 3 3 0 LXG domain of WXG superfamily ZapB PF06005.12 CDW56855.1 - 3.9 8.0 7.8 6 7.4 1.5 3.3 3 0 0 3 3 3 0 Cell division protein ZapB Baculo_PEP_C PF04513.12 CDW56855.1 - 5.9 6.9 7.9 8.9 6.3 0.3 3.7 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Laminin_I PF06008.14 CDW56855.1 - 9 5.9 27.5 0.49 10.1 13.5 2.9 2 2 0 2 2 2 0 Laminin Domain I Ank_2 PF12796.7 CDW56857.1 - 3.3e-26 91.7 0.5 3.7e-16 59.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW56857.1 - 6.5e-17 61.4 3.1 1.1e-09 38.3 0.2 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW56857.1 - 7.9e-16 58.2 0.1 1.5e-10 41.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW56857.1 - 1.8e-15 55.4 0.1 6.1e-06 26.2 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 CDW56857.1 - 1.2e-14 54.0 1.3 2.7e-06 27.6 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat TPR_12 PF13424.6 CDW56857.1 - 2.9e-08 33.9 6.7 0.0023 18.2 0.0 5.5 5 1 2 7 7 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW56857.1 - 4.4e-07 29.5 1.3 0.0028 17.7 0.1 4.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDW56857.1 - 8.5e-07 28.5 2.2 4.1e-05 23.2 0.2 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW56857.1 - 9.2e-06 25.5 4.5 0.017 15.3 0.0 4.6 5 0 0 5 5 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW56857.1 - 0.0002 20.9 0.2 0.026 14.2 0.1 3.2 2 0 0 2 2 2 1 TPR repeat DUF2225 PF09986.9 CDW56857.1 - 0.0016 18.2 7.6 0.011 15.5 1.2 2.3 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) Sec8_exocyst PF04048.14 CDW56857.1 - 0.0061 16.4 1.7 0.13 12.2 0.1 2.7 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain TPR_10 PF13374.6 CDW56857.1 - 0.0062 16.4 2.0 0.93 9.5 0.1 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDW56857.1 - 0.007 17.1 0.0 3.9 8.6 0.0 3.6 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW56857.1 - 0.066 13.4 2.9 4.9 7.5 0.0 3.8 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 CDW56857.1 - 0.083 12.2 2.3 0.18 11.2 2.3 1.6 1 0 0 1 1 1 0 MalT-like TPR region LRR_6 PF13516.6 CDW56857.1 - 1.2 9.4 6.9 0.54 10.5 0.4 3.6 4 0 0 4 4 4 0 Leucine Rich repeat SPOB_a PF14689.6 CDW56857.1 - 1.7 8.4 7.2 3.6 7.4 0.2 3.2 4 0 0 4 4 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain DUF3856 PF12968.7 CDW56857.1 - 2.1 8.4 5.0 1.6 8.8 0.3 2.7 3 0 0 3 3 2 0 Domain of Unknown Function (DUF3856) FadA PF09403.10 CDW56857.1 - 2.6 8.6 10.1 0.61 10.6 0.1 3.7 4 0 0 4 4 3 0 Adhesion protein FadA WD40 PF00400.32 CDW56858.1 - 9.4e-32 108.6 29.9 0.00016 22.4 0.0 12.7 13 1 0 13 13 13 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW56858.1 - 2.4e-16 59.8 0.2 1.2e-05 25.5 0.0 6.4 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW56858.1 - 1.8e-12 47.2 0.6 0.012 15.0 0.0 4.1 3 1 1 4 4 4 4 WD40-like domain PQQ_2 PF13360.6 CDW56858.1 - 0.00038 20.1 0.0 0.027 14.0 0.0 3.0 1 1 1 2 2 2 1 PQQ-like domain RAB3GAP2_N PF14655.6 CDW56858.1 - 0.0014 18.0 0.0 0.56 9.4 0.0 3.0 2 1 1 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_3 PF13570.6 CDW56858.1 - 0.0015 19.0 0.0 0.32 11.5 0.0 3.4 2 0 0 2 2 2 1 PQQ-like domain BBS2_Mid PF14783.6 CDW56858.1 - 0.019 15.0 0.1 1.3 9.1 0.0 3.8 4 1 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 CDW56858.1 - 0.042 12.2 4.6 0.25 9.6 0.4 3.2 3 1 1 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz PQQ PF01011.21 CDW56858.1 - 0.17 11.8 0.0 0.87 9.6 0.0 2.2 2 0 0 2 2 2 0 PQQ enzyme repeat AAA_16 PF13191.6 CDW56860.1 - 4.9e-10 40.1 0.0 1.2e-09 38.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CDW56860.1 - 0.00028 20.9 0.4 0.001 19.0 0.0 2.2 2 0 0 2 2 2 1 NACHT domain DUF2791 PF10923.8 CDW56860.1 - 0.018 13.9 0.0 0.038 12.8 0.0 1.5 2 0 0 2 2 2 0 P-loop Domain of unknown function (DUF2791) AAA_22 PF13401.6 CDW56860.1 - 0.02 15.2 0.0 0.087 13.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDW56860.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CDW56860.1 - 0.09 12.5 0.0 6.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 CDW56860.1 - 0.18 12.2 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain SET PF00856.28 CDW56861.1 - 3.1e-17 63.5 0.0 2.4e-16 60.6 0.0 2.1 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 CDW56861.1 - 3.7e-11 43.6 7.8 3.8e-11 43.6 3.2 2.3 2 0 0 2 2 2 1 Pre-SET motif Mesd PF10185.9 CDW56864.1 - 7.4e-64 214.4 0.7 8.3e-64 214.2 0.7 1.0 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor SecD-TM1 PF13721.6 CDW56864.1 - 0.16 12.4 0.0 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 SecD export protein N-terminal TM region EF-hand_1 PF00036.32 CDW56865.1 - 1.1e-26 90.3 17.5 1.4e-06 27.5 0.7 4.7 4 1 1 5 5 5 4 EF hand EF-hand_7 PF13499.6 CDW56865.1 - 1.3e-25 89.6 4.1 2.4e-13 50.3 0.7 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW56865.1 - 6.1e-22 75.6 11.7 8.4e-05 22.2 0.2 4.6 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 CDW56865.1 - 3.3e-20 70.6 13.8 3.1e-05 23.3 0.1 4.9 4 1 1 5 5 5 4 EF hand EF-hand_8 PF13833.6 CDW56865.1 - 3.9e-16 58.6 15.3 0.00045 20.0 1.1 4.7 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW56865.1 - 2.1e-07 31.3 0.2 0.0099 16.2 0.1 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDW56865.1 - 4.5e-07 29.8 4.2 0.024 14.6 0.2 3.8 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 CDW56865.1 - 0.001 19.0 5.0 7.1 6.5 0.0 3.8 1 1 3 4 4 4 3 Caleosin related protein EF-hand_9 PF14658.6 CDW56865.1 - 0.014 15.7 0.1 1.4 9.3 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain Sigma54_CBD PF04963.13 CDW56865.1 - 0.11 12.3 0.2 5.2 6.9 0.0 2.2 1 1 0 2 2 2 0 Sigma-54 factor, core binding domain Dockerin_1 PF00404.18 CDW56865.1 - 2.5 8.3 5.3 25 5.1 1.4 3.2 1 1 1 2 2 2 0 Dockerin type I domain L51_S25_CI-B8 PF05047.16 CDW56866.1 - 6.9e-17 61.1 0.2 1.3e-12 47.4 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Top6b_C PF18000.1 CDW56866.1 - 0.15 12.2 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain EF-hand_4 PF12763.7 CDW56867.1 - 1e-13 51.1 0.0 4.3e-13 49.1 0.0 2.0 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 CDW56867.1 - 1.4e-05 24.3 0.0 3.1e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CDW56867.1 - 0.00019 21.8 0.0 0.00041 20.7 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 CDW56867.1 - 0.008 16.0 0.1 0.018 14.9 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair DUF3452 PF11934.8 CDW56867.1 - 0.025 14.1 0.0 0.057 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) EF-hand_6 PF13405.6 CDW56867.1 - 0.04 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain DUF5600 PF18150.1 CDW56868.1 - 1.5e-46 157.4 2.3 1.5e-46 157.4 2.3 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 CDW56868.1 - 3.4e-17 62.3 0.0 1.2e-16 60.6 0.0 1.9 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.5 CDW56868.1 - 5.9e-17 61.3 6.3 1.7e-16 59.8 6.3 1.9 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 CDW56868.1 - 3.6e-14 53.2 0.0 1.9e-13 50.8 0.0 2.2 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CDW56868.1 - 3.2e-07 30.4 0.0 9.5e-07 28.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_8 PF13833.6 CDW56868.1 - 0.00037 20.3 0.2 0.53 10.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW56868.1 - 0.0008 18.8 0.1 0.0046 16.4 0.1 2.4 1 0 0 1 1 1 1 EF hand Roc PF08477.13 CDW56868.1 - 0.0061 16.8 0.0 2.2 8.5 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 CDW56868.1 - 0.025 14.5 0.0 2.2 8.1 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase EF-hand_7 PF13499.6 CDW56868.1 - 0.044 14.2 0.1 2.5 8.6 0.0 2.9 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 CDW56868.1 - 0.062 13.3 0.1 0.38 10.8 0.1 2.4 1 0 0 1 1 1 0 EF-hand domain AAA_16 PF13191.6 CDW56868.1 - 0.068 13.6 0.0 0.32 11.4 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain Gtr1_RagA PF04670.12 CDW56868.1 - 0.074 12.4 0.0 0.51 9.6 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_28 PF13521.6 CDW56868.1 - 0.08 13.2 0.0 0.28 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CDW56868.1 - 0.11 12.1 0.0 9.3 5.8 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Popeye PF04831.13 CDW56868.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Popeye protein conserved region CLP1_P PF16575.5 CDW56868.1 - 0.19 11.5 0.3 47 3.7 0.0 3.6 4 0 0 4 4 4 0 mRNA cleavage and polyadenylation factor CLP1 P-loop UME PF08064.13 CDW56869.1 - 5.3e-11 42.3 0.0 1.5e-10 40.8 0.0 1.9 1 0 0 1 1 1 1 UME (NUC010) domain TPR_19 PF14559.6 CDW56869.1 - 0.00019 21.8 0.0 0.00075 20.0 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat PI3_PI4_kinase PF00454.27 CDW56870.1 - 3.6e-56 190.8 0.2 6.3e-56 190.0 0.2 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 CDW56870.1 - 1.5e-23 83.6 9.9 4.7e-22 78.7 9.3 2.3 2 0 0 2 2 2 2 FAT domain FATC PF02260.20 CDW56870.1 - 1.7e-14 53.3 0.0 3.3e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 FATC domain zf-rbx1 PF12678.7 CDW56871.1 - 4e-18 65.4 14.3 5.6e-18 65.0 14.3 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDW56871.1 - 1.5e-13 50.6 10.0 2.2e-13 50.1 10.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CDW56871.1 - 5.4e-05 23.5 17.2 0.0011 19.3 17.2 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW56871.1 - 0.00037 20.3 8.7 0.00037 20.3 8.7 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CDW56871.1 - 0.021 14.5 1.8 0.021 14.5 1.8 2.3 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 CDW56871.1 - 0.032 14.1 14.4 0.26 11.2 14.4 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW56871.1 - 0.06 13.4 14.6 0.74 9.9 14.6 2.2 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 CDW56871.1 - 0.2 11.6 12.9 0.75 9.8 13.0 2.0 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 CDW56871.1 - 4.4 7.1 15.4 0.97 9.2 7.9 2.4 1 1 1 2 2 2 0 RING-like zinc finger CBFD_NFYB_HMF PF00808.23 CDW56872.1 - 5.7e-10 39.3 0.1 9.4e-10 38.6 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDW56872.1 - 0.00074 19.9 0.3 0.0016 18.8 0.3 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 RFXA_RFXANK_bdg PF15289.6 CDW56872.1 - 0.0012 19.2 1.4 0.069 13.5 0.9 2.3 1 1 1 2 2 2 1 Regulatory factor X-associated C-terminal binding domain Sec1 PF00995.23 CDW56873.1 - 4.3e-115 386.2 0.1 5e-115 385.9 0.1 1.0 1 0 0 1 1 1 1 Sec1 family Pkinase PF00069.25 CDW56874.1 - 9.2e-135 448.1 0.0 2e-68 230.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW56874.1 - 1.3e-78 263.9 0.0 2.4e-46 158.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase DCX PF03607.17 CDW56874.1 - 6.2e-36 122.3 4.2 7.1e-20 70.9 0.0 3.4 4 0 0 4 4 4 2 Doublecortin Mod_r PF07200.13 CDW56874.1 - 1.1e-32 113.2 7.2 1.1e-32 113.2 7.2 2.7 3 0 0 3 3 3 1 Modifier of rudimentary (Mod(r)) protein DUF1712 PF08217.11 CDW56874.1 - 1.5e-23 83.2 3.2 4.4e-21 75.0 3.2 3.0 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1712) DUF3543 PF12063.8 CDW56874.1 - 1.8e-17 63.6 3.9 2.1e-16 60.1 3.9 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Kinase-like PF14531.6 CDW56874.1 - 8.9e-11 41.6 0.0 1.9e-05 24.1 0.0 3.0 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 CDW56874.1 - 1.5e-10 40.8 0.2 4.3e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW56874.1 - 1.9e-07 31.3 0.5 0.22 11.4 0.1 3.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 CDW56874.1 - 2.4e-07 30.5 0.7 0.0037 16.9 0.0 2.5 2 0 0 2 2 2 2 RIO1 family Pkinase_fungal PF17667.1 CDW56874.1 - 2.8e-07 29.7 0.0 0.0077 15.1 0.0 2.4 2 0 0 2 2 2 2 Fungal protein kinase Peptidase_M3_N PF08439.10 CDW56874.1 - 0.011 16.0 0.7 0.036 14.3 0.1 2.3 2 0 0 2 2 2 0 Oligopeptidase F FTA2 PF13095.6 CDW56874.1 - 0.041 13.5 0.0 6 6.4 0.0 2.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.11 CDW56874.1 - 0.1 11.5 0.1 14 4.5 0.0 2.3 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase VCBS PF13517.6 CDW56876.1 - 1.8e-18 66.9 0.6 4.7e-07 30.3 0.2 4.7 4 2 0 4 4 4 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CDW56876.1 - 3.1e-09 36.8 4.7 0.00049 20.2 0.0 4.1 5 0 0 5 5 5 2 FG-GAP repeat TcdB_toxin_midN PF12256.8 CDW56876.1 - 0.04 13.3 0.0 9.9 5.5 0.0 2.8 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/N-terminal region zf-RanBP PF00641.18 CDW56877.1 - 0.00029 20.1 0.5 0.00029 20.1 0.5 1.8 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Nop14 PF04147.12 CDW56877.1 - 0.34 9.1 25.5 0.55 8.4 25.5 1.2 1 0 0 1 1 1 0 Nop14-like family DUF953 PF06110.11 CDW56878.1 - 1.2e-37 128.2 0.1 1.4e-37 128.0 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 CDW56878.1 - 0.0021 18.0 0.7 0.0026 17.7 0.7 1.5 1 1 0 1 1 1 1 Thioredoxin DUF953 PF06110.11 CDW56879.1 - 5.2e-43 145.4 0.1 6e-43 145.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 CDW56879.1 - 0.042 13.8 0.6 0.081 12.9 0.6 1.6 1 1 0 1 1 1 0 Thioredoxin Thioredoxin_9 PF14595.6 CDW56879.1 - 0.18 11.6 0.3 0.21 11.3 0.3 1.3 1 0 0 1 1 1 0 Thioredoxin HLH PF00010.26 CDW56880.1 - 3e-08 33.5 3.8 3e-08 33.5 3.8 1.9 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain EGF PF00008.27 CDW56881.1 - 2.2e-16 59.8 37.7 5.6e-07 29.7 7.7 3.5 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 CDW56881.1 - 3.8e-13 49.5 31.4 3e-05 24.5 4.7 4.3 3 1 0 3 3 3 3 Human growth factor-like EGF EGF_2 PF07974.13 CDW56881.1 - 2.7e-06 27.6 46.7 0.0008 19.7 8.4 3.6 3 0 0 3 3 3 3 EGF-like domain EGF_CA PF07645.15 CDW56881.1 - 0.001 19.3 37.3 0.12 12.6 11.9 3.5 1 1 2 3 3 3 2 Calcium-binding EGF domain FXa_inhibition PF14670.6 CDW56881.1 - 0.0033 17.7 35.3 0.035 14.4 5.9 3.8 3 1 1 4 4 4 3 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW56881.1 - 0.039 14.1 29.6 0.1 12.8 1.5 3.7 3 1 0 3 3 3 0 EGF domain Laminin_EGF PF00053.24 CDW56881.1 - 0.97 9.6 36.2 4.5 7.5 5.6 3.5 1 1 2 3 3 3 0 Laminin EGF domain DUF2997 PF11211.8 CDW56881.1 - 2.6 7.9 6.7 12 5.7 0.2 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2997) EGF PF00008.27 CDW56882.1 - 1.5e-09 37.9 46.6 2.6e-06 27.6 11.1 5.2 5 0 0 5 5 5 3 EGF-like domain Adeno_E3B PF03376.14 CDW56882.1 - 0.082 13.2 0.4 0.17 12.1 0.4 1.4 1 0 0 1 1 1 0 Adenovirus E3B protein Cadherin_C_2 PF16492.5 CDW56882.1 - 0.14 12.9 0.1 0.42 11.4 0.1 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Orf78 PF06024.12 CDW56882.1 - 0.16 12.3 0.1 0.29 11.4 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) EGF_2 PF07974.13 CDW56882.1 - 0.26 11.7 51.0 1.4 9.4 13.0 5.0 4 0 0 4 4 4 0 EGF-like domain DUF5560 PF17715.1 CDW56882.1 - 2.7 7.4 6.8 6.2 6.2 1.5 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5560) hEGF PF12661.7 CDW56882.1 - 3 8.6 36.7 0.2 12.3 7.7 5.4 4 0 0 4 4 4 0 Human growth factor-like EGF E1_DerP2_DerF2 PF02221.15 CDW56883.1 - 3.1e-12 47.1 0.0 3.8e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 ML domain YfkD PF14167.6 CDW56883.1 - 0.095 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 YfkD-like protein Homeodomain PF00046.29 CDW56884.1 - 2.4e-22 78.5 3.3 5.3e-22 77.4 3.3 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW56884.1 - 0.017 15.0 0.4 0.05 13.5 0.0 2.0 2 0 0 2 2 2 0 Homeobox KN domain PhoLip_ATPase_C PF16212.5 CDW56885.1 - 3.7e-62 210.3 49.2 1.5e-43 149.3 26.3 4.3 3 1 0 3 3 3 2 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDW56885.1 - 2.8e-20 71.8 2.6 2.8e-20 71.8 2.6 2.4 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CDW56885.1 - 1.1e-11 45.5 1.6 0.00012 22.5 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CDW56885.1 - 1.4e-11 44.3 0.0 7.9e-11 41.9 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDW56885.1 - 0.00012 21.6 0.0 0.00039 20.0 0.0 2.0 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDW56885.1 - 0.029 14.1 0.3 0.053 13.3 0.3 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NUDIX PF00293.28 CDW56887.1 - 2.1e-13 50.4 0.0 2.4e-13 50.3 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain Nic96 PF04097.14 CDW56888.1 - 5.3e-90 302.7 0.1 1.4e-55 189.0 1.5 3.1 1 1 2 3 3 3 3 Nup93/Nic96 Protoglobin PF11563.8 CDW56888.1 - 0.033 14.1 0.0 6.1 6.7 0.0 3.3 3 0 0 3 3 3 0 Protoglobin TPR_14 PF13428.6 CDW56888.1 - 0.12 13.2 0.9 21 6.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat dsrm PF00035.26 CDW56889.1 - 0.0013 19.4 0.0 0.02 15.6 0.0 2.4 1 1 0 1 1 1 1 Double-stranded RNA binding motif Dicer_dimer PF03368.14 CDW56889.1 - 0.0021 18.2 0.1 0.0048 17.0 0.0 1.6 1 1 1 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 CDW56890.1 - 7.6e-15 55.2 0.0 1.7e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 CDW56890.1 - 5.5e-09 36.3 0.0 1.3e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 CDW56890.1 - 5e-06 26.4 0.1 1.1e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CDW56890.1 - 0.0011 19.3 0.0 0.0068 16.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CDW56890.1 - 0.14 12.2 0.0 7.7 6.6 0.0 3.1 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 CDW56890.1 - 0.16 11.0 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein OB_NTP_bind PF07717.16 CDW56890.1 - 0.16 12.4 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold ATPase PF06745.13 CDW56890.1 - 0.16 11.3 0.0 0.37 10.1 0.0 1.5 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 CDW56890.1 - 0.18 11.2 0.0 0.64 9.4 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein EF-hand_1 PF00036.32 CDW56891.1 - 5.8e-38 125.6 9.9 9.2e-10 37.4 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDW56891.1 - 9.8e-33 112.4 1.5 2.4e-15 56.7 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CDW56891.1 - 9.9e-30 102.2 9.5 3.4e-13 49.2 0.1 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CDW56891.1 - 2.4e-27 92.5 5.2 1.5e-09 37.0 0.1 4.4 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 CDW56891.1 - 1.3e-24 84.5 7.3 8.8e-07 28.2 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CDW56891.1 - 2.3e-13 50.3 0.1 3e-09 37.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CDW56891.1 - 1.5e-07 31.3 0.2 0.014 15.4 0.0 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CDW56891.1 - 3.2e-06 27.4 0.0 0.04 14.2 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 CDW56891.1 - 2.1e-05 24.5 0.0 0.051 13.6 0.0 3.1 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 CDW56891.1 - 0.00015 22.6 0.0 0.062 14.2 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 CDW56891.1 - 0.00018 21.5 0.4 0.0011 19.0 0.0 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 CDW56891.1 - 0.001 19.2 4.9 0.14 12.4 0.6 3.0 1 1 1 2 2 2 2 Dockerin type I domain DUF3349 PF11829.8 CDW56891.1 - 0.0027 18.5 0.4 1.6 9.5 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 CDW56891.1 - 0.0027 17.6 0.4 0.52 10.2 0.0 3.1 1 1 2 3 3 3 1 Caleosin related protein DUF4497 PF14924.6 CDW56891.1 - 0.0039 17.6 0.0 2 8.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4497) RNA_pol_Rpb4 PF03874.16 CDW56891.1 - 0.004 17.5 0.6 1.9 8.9 0.1 2.6 3 0 0 3 3 2 1 RNA polymerase Rpb4 DUF1103 PF06513.11 CDW56891.1 - 0.0096 15.6 2.1 0.012 15.3 2.1 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Poly_export PF02563.16 CDW56891.1 - 0.021 15.0 0.0 1.2 9.4 0.0 2.9 2 1 1 3 3 3 0 Polysaccharide biosynthesis/export protein MotA_activ PF09114.10 CDW56891.1 - 0.024 14.8 0.3 0.32 11.2 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain dCache_2 PF08269.11 CDW56891.1 - 0.032 13.4 0.1 2.2 7.4 0.0 2.2 1 1 1 2 2 2 0 Cache domain TerB PF05099.13 CDW56891.1 - 0.055 13.4 0.4 0.53 10.2 0.1 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB SurA_N_2 PF13623.6 CDW56891.1 - 0.063 13.1 0.4 3.7 7.4 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain DUF2267 PF10025.9 CDW56891.1 - 0.07 13.4 0.0 0.22 11.8 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Fe_hyd_lg_C PF02906.14 CDW56891.1 - 0.07 12.8 0.4 0.26 10.9 0.4 1.8 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain EF-hand_14 PF17959.1 CDW56891.1 - 0.11 12.8 0.1 12 6.4 0.0 2.3 1 1 1 2 2 2 0 EF-hand domain TetR_C_7 PF14246.6 CDW56891.1 - 0.13 12.3 0.0 10 6.2 0.0 2.7 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain Spore_III_AB PF09548.10 CDW56891.1 - 0.16 12.1 0.2 0.32 11.1 0.2 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) SapB_1 PF05184.15 CDW56891.1 - 0.36 10.9 1.2 32 4.7 0.0 3.5 4 0 0 4 4 4 0 Saposin-like type B, region 1 2OG-FeII_Oxy_3 PF13640.6 CDW56892.1 - 3e-16 60.1 0.0 7.5e-16 58.8 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 CDW56892.1 - 2.5e-11 44.1 0.0 5.8e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PH PF00169.29 CDW56893.1 - 6.9e-16 58.7 0.8 3.8e-15 56.3 0.7 2.3 3 0 0 3 3 3 1 PH domain PH_8 PF15409.6 CDW56893.1 - 1.6e-05 25.1 0.1 5.9e-05 23.3 0.1 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 CDW56893.1 - 5.6e-05 23.2 0.2 0.00023 21.2 0.2 2.0 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 CDW56893.1 - 0.044 14.2 1.0 0.21 12.0 1.0 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 CDW56893.1 - 0.12 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain MIP PF00230.20 CDW56894.1 - 8.8e-40 136.8 2.8 1e-39 136.6 2.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein Nop53 PF07767.11 CDW56895.1 - 1.1e-49 169.9 21.8 1.4e-49 169.6 21.8 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) CLPTM1 PF05602.12 CDW56895.1 - 0.057 12.4 1.5 0.065 12.2 0.2 1.5 1 1 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) CRA PF06589.11 CDW56895.1 - 3.1 7.9 11.2 12 6.0 10.0 2.2 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) LMBR1 PF04791.16 CDW56895.1 - 8.9 5.1 5.8 12 4.7 5.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein LSM PF01423.22 CDW56896.1 - 6.6e-15 54.6 0.0 1.3e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 LSM domain Cauli_DNA-bind PF03310.13 CDW56896.1 - 0.17 12.0 0.1 0.35 11.0 0.1 1.5 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein Frizzled PF01534.17 CDW56897.1 - 1.5e-130 435.0 23.0 2.1e-130 434.5 23.0 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 CDW56897.1 - 7.5e-35 119.9 3.1 1.8e-34 118.6 3.1 1.7 1 0 0 1 1 1 1 Fz domain Coatomer_E PF04733.14 CDW56898.1 - 1.2e-94 317.0 0.2 1.3e-94 316.8 0.2 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 CDW56898.1 - 4.8e-10 39.8 0.1 0.0004 20.8 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW56898.1 - 0.00013 21.9 0.2 0.41 10.9 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 CDW56898.1 - 0.0012 18.4 2.3 0.0024 17.5 0.9 2.1 1 1 0 2 2 2 1 Bacterial type III secretion protein (HrpB1_HrpK) ANAPC3 PF12895.7 CDW56898.1 - 0.011 16.0 2.5 3.6 7.9 0.4 3.5 2 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CDW56898.1 - 0.015 15.1 0.1 3.7 7.5 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDW56898.1 - 0.015 15.5 0.0 3.3 8.1 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat PIRT PF15099.6 CDW56900.1 - 0.27 10.8 0.4 0.4 10.2 0.4 1.2 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family RRM_1 PF00076.22 CDW56901.1 - 1.7e-06 27.8 0.0 2.8e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_H2-Ydr279 PF09468.10 CDW56902.1 - 3.5e-07 30.6 0.9 2.2e-06 28.0 0.9 1.9 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain CEBP_ZZ PF16366.5 CDW56902.1 - 0.37 11.0 4.5 0.81 10.0 4.5 1.5 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-HIT PF04438.16 CDW56903.1 - 8.3e-07 28.8 8.0 8.3e-07 28.8 8.0 1.5 2 0 0 2 2 2 1 HIT zinc finger zf-MYND PF01753.18 CDW56903.1 - 0.28 11.3 8.4 0.16 12.1 6.0 1.8 1 1 0 1 1 1 0 MYND finger Astacin PF01400.24 CDW56906.1 - 3.5e-73 245.3 0.1 5.7e-73 244.6 0.1 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 CDW56906.1 - 2.8e-09 37.3 5.4 2.8e-09 37.3 5.4 2.0 2 0 0 2 2 2 1 ShK domain-like EPL1 PF10513.9 CDW56907.1 - 5.4e-05 23.6 0.1 9.7e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like DUF3278 PF11683.8 CDW56907.1 - 0.16 12.0 0.1 0.27 11.3 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) PAN_1 PF00024.26 CDW56909.1 - 7.3e-09 35.5 0.4 1.5e-08 34.5 0.4 1.5 1 0 0 1 1 1 1 PAN domain HTH_Tnp_Tc3_1 PF11427.8 CDW56909.1 - 0.0063 16.3 0.3 0.023 14.5 0.0 2.1 2 0 0 2 2 2 1 Tc3 transposase TSP_1 PF00090.19 CDW56909.1 - 0.57 10.4 4.9 0.18 12.1 1.3 2.1 2 0 0 2 2 2 0 Thrombospondin type 1 domain Suf PF05843.14 CDW56910.1 - 4.2e-57 194.4 19.2 1.2e-52 179.8 1.3 5.0 4 2 1 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CDW56910.1 - 0.0001 22.8 1.0 22 6.2 0.0 5.7 3 2 3 6 6 6 2 Tetratricopeptide repeat NRDE-2 PF08424.10 CDW56910.1 - 0.0013 17.9 13.2 0.072 12.2 0.1 5.3 2 1 4 6 6 6 4 NRDE-2, necessary for RNA interference TPR_19 PF14559.6 CDW56910.1 - 0.0036 17.8 0.0 0.016 15.7 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Ferritin PF00210.24 CDW56911.1 - 1.2e-40 138.8 0.3 1.5e-40 138.4 0.3 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 CDW56911.1 - 0.0018 18.7 0.1 0.0025 18.2 0.1 1.4 1 1 0 1 1 1 1 Rubrerythrin Ig_3 PF13927.6 CDW56912.1 - 4.9e-53 177.6 0.0 4.8e-12 46.3 0.0 7.2 7 0 0 7 7 7 6 Immunoglobulin domain I-set PF07679.16 CDW56912.1 - 8e-39 131.6 0.0 8e-13 48.3 0.0 7.5 8 0 0 8 8 7 4 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW56912.1 - 1.1e-36 125.0 0.1 5.3e-10 39.5 0.0 6.7 6 1 0 6 6 6 4 Immunoglobulin domain ig PF00047.25 CDW56912.1 - 1.7e-31 108.2 0.5 6.3e-09 35.9 0.0 6.6 7 0 0 7 7 7 4 Immunoglobulin domain fn3 PF00041.21 CDW56912.1 - 4.3e-23 81.5 1.8 5.4e-07 29.9 0.1 4.6 4 0 0 4 4 4 4 Fibronectin type III domain V-set PF07686.17 CDW56912.1 - 8.5e-13 48.4 10.2 0.091 12.9 0.0 10.2 7 5 2 9 9 9 2 Immunoglobulin V-set domain Ig_6 PF18452.1 CDW56912.1 - 2.8e-06 26.8 0.0 4 7.1 0.0 4.5 4 0 0 4 4 4 3 Immunoglobulin domain Ig_5 PF16681.5 CDW56912.1 - 3.5e-05 24.1 0.1 0.35 11.3 0.0 4.3 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 CDW56912.1 - 0.0023 18.2 0.1 1.2 9.4 0.0 4.8 4 0 0 4 4 4 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 CDW56912.1 - 0.0044 17.0 0.1 11 6.1 0.0 5.2 6 0 0 6 6 6 1 Izumo-like Immunoglobulin domain Pur_ac_phosph_N PF16656.5 CDW56912.1 - 0.023 15.3 3.0 0.45 11.1 0.1 3.3 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain C2-set PF05790.15 CDW56912.1 - 0.044 14.0 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin C2-set domain V-set_CD47 PF08204.11 CDW56912.1 - 0.14 12.2 0.0 8.2 6.4 0.0 3.4 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain Peptidase_M24 PF00557.24 CDW56913.1 - 2.3e-44 151.6 0.1 2.8e-44 151.3 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Ribophorin_I PF04597.14 CDW56914.1 - 8.8e-102 341.5 2.9 1.1e-101 341.2 2.9 1.1 1 0 0 1 1 1 1 Ribophorin I HR1 PF02185.16 CDW56914.1 - 0.0014 18.7 3.5 0.018 15.2 1.1 2.5 2 0 0 2 2 2 1 Hr1 repeat DUF948 PF06103.11 CDW56914.1 - 0.012 15.8 0.5 1.2 9.4 0.5 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) HSCB_C PF07743.13 CDW56914.1 - 0.018 15.5 1.9 0.046 14.2 1.9 1.7 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain DNA_repr_REX1B PF14966.6 CDW56914.1 - 0.08 13.6 1.9 0.19 12.4 1.3 1.9 2 0 0 2 2 2 0 DNA repair REX1-B DUF883 PF05957.13 CDW56914.1 - 0.89 10.2 4.5 2.8 8.6 2.4 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) IMPDH PF00478.25 CDW56915.1 - 2.4e-123 411.5 0.8 2.9e-123 411.3 0.8 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CDW56915.1 - 6.6e-10 38.5 2.3 5.9e-09 35.4 2.3 2.0 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 CDW56915.1 - 3.2e-09 36.6 2.2 3.1e-07 30.1 0.5 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 CDW56915.1 - 2.9e-07 30.2 0.8 2.3e-06 27.2 0.8 2.1 1 1 0 1 1 1 1 Histidine biosynthesis protein CBS PF00571.28 CDW56915.1 - 3.9e-05 24.0 0.0 0.4 11.2 0.0 3.2 3 0 0 3 3 3 2 CBS domain ThiG PF05690.14 CDW56915.1 - 0.00016 21.1 2.0 0.0011 18.4 1.4 2.2 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG NanE PF04131.14 CDW56915.1 - 0.00074 18.8 0.3 0.0016 17.6 0.3 1.6 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase Dus PF01207.17 CDW56915.1 - 0.0038 16.4 0.4 0.26 10.3 0.0 2.2 1 1 1 2 2 2 1 Dihydrouridine synthase (Dus) Glu_synthase PF01645.17 CDW56915.1 - 0.0074 15.5 0.9 0.016 14.4 0.9 1.5 1 0 0 1 1 1 1 Conserved region in glutamate synthase YpsA PF06908.11 CDW56915.1 - 0.068 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 YspA SLOG family BATS PF06968.13 CDW56915.1 - 0.069 13.3 0.2 0.38 10.9 0.0 2.3 2 1 0 2 2 2 0 Biotin and Thiamin Synthesis associated domain DHO_dh PF01180.21 CDW56915.1 - 0.13 11.4 1.3 0.34 10.1 1.3 1.7 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase TFCD_C PF12612.8 CDW56916.1 - 6.2e-18 65.3 1.1 2.2e-17 63.5 0.2 2.4 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.6 CDW56916.1 - 9.4e-07 29.1 2.0 0.33 11.4 0.0 5.2 5 0 0 5 5 5 2 HEAT repeats HEAT PF02985.22 CDW56916.1 - 2.3e-06 27.4 16.3 0.0065 16.6 0.0 8.5 9 0 0 9 9 9 2 HEAT repeat Vac14_Fab1_bd PF12755.7 CDW56916.1 - 0.0013 19.3 3.8 16 6.2 0.0 6.4 7 0 0 7 7 7 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CDW56916.1 - 0.0081 16.6 10.0 0.12 13.0 0.0 6.2 7 0 0 7 7 7 1 HEAT-like repeat TPR_1 PF00515.28 CDW56917.1 - 9.3e-14 50.6 3.9 1.3e-09 37.4 0.6 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW56917.1 - 1.2e-09 37.6 3.2 3.6e-05 23.5 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW56917.1 - 6.6e-08 32.1 0.3 0.032 13.9 0.1 3.7 2 1 1 3 3 3 3 TPR repeat SGTA_dimer PF16546.5 CDW56917.1 - 6.9e-08 32.2 0.0 1.3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_7 PF13176.6 CDW56917.1 - 2.3e-05 24.1 0.7 0.026 14.5 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW56917.1 - 8.8e-05 23.0 3.8 0.17 12.8 0.1 3.8 4 2 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDW56917.1 - 0.00048 20.4 0.1 0.41 11.0 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW56917.1 - 0.00059 20.4 1.0 0.002 18.7 0.1 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW56917.1 - 0.00091 19.3 0.8 0.095 13.0 0.4 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDW56917.1 - 0.004 16.4 0.1 0.031 13.5 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW56917.1 - 0.014 15.5 0.8 0.052 13.6 0.2 2.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 CDW56917.1 - 0.016 15.5 0.5 2 9.0 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat BTAD PF03704.17 CDW56917.1 - 0.029 14.8 0.2 15 6.0 0.0 3.0 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TPR_19 PF14559.6 CDW56917.1 - 0.032 14.7 1.5 9.6 6.8 0.0 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDW56917.1 - 0.079 12.9 0.4 0.79 9.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-CCHC_6 PF15288.6 CDW56917.1 - 0.15 11.9 0.0 0.38 10.6 0.0 1.6 1 0 0 1 1 1 0 Zinc knuckle TPR_9 PF13371.6 CDW56917.1 - 0.3 11.3 2.8 6 7.1 0.2 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CDW56918.1 - 0.00014 21.5 0.2 0.00046 19.8 0.3 1.9 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 CDW56918.1 - 0.024 14.7 0.6 0.088 13.0 0.3 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDW56918.1 - 0.048 13.5 0.5 0.098 12.5 0.5 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat AbiJ_NTD3 PF18860.1 CDW56918.1 - 0.081 12.4 0.1 3 7.3 0.0 2.2 1 1 0 2 2 2 0 AbiJ N-terminal domain 3 TPR_19 PF14559.6 CDW56918.1 - 0.17 12.4 3.2 1.1 9.9 0.1 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDW56918.1 - 0.64 10.5 2.6 6.5 7.4 0.3 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ASC PF00858.24 CDW56919.1 - 6.5e-102 341.8 12.6 9.3e-99 331.4 12.6 2.1 1 1 0 1 1 1 1 Amiloride-sensitive sodium channel Tmemb_185A PF10269.9 CDW56919.1 - 0.12 12.1 0.6 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 Transmembrane Fragile-X-F protein FAD_binding_3 PF01494.19 CDW56920.1 - 4.1e-19 69.0 0.0 2e-10 40.4 0.0 2.4 2 1 0 2 2 2 2 FAD binding domain SE PF08491.10 CDW56920.1 - 9e-07 28.2 0.0 1.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Squalene epoxidase Trp_halogenase PF04820.14 CDW56920.1 - 1e-05 24.6 0.4 0.061 12.2 0.0 3.1 2 1 1 3 3 3 3 Tryptophan halogenase Pyr_redox_2 PF07992.14 CDW56920.1 - 2.9e-05 23.5 0.2 0.002 17.4 0.2 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CDW56920.1 - 0.00013 21.2 1.2 1.7 7.6 0.0 3.1 3 0 0 3 3 3 3 Lycopene cyclase protein DAO PF01266.24 CDW56920.1 - 0.013 15.1 0.4 0.073 12.6 0.2 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CDW56920.1 - 0.12 13.0 0.1 0.37 11.4 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ETX_MTX2 PF03318.13 CDW56921.1 - 0.00077 19.3 0.1 0.0021 17.8 0.1 1.6 1 1 1 2 2 2 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 EMC3_TMCO1 PF01956.16 CDW56922.1 - 3.5e-33 114.7 0.1 4.4e-33 114.4 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Wzy_C PF04932.15 CDW56922.1 - 0.011 15.4 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 O-Antigen ligase Exonuc_VII_L PF02601.15 CDW56922.1 - 0.03 13.9 0.1 0.034 13.7 0.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LapA_dom PF06305.11 CDW56922.1 - 0.044 13.6 7.3 0.44 10.4 0.0 3.3 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain CHD5 PF04420.14 CDW56922.1 - 0.66 9.8 2.3 2.8 7.8 2.3 1.9 1 1 0 1 1 1 0 CHD5-like protein DivIC PF04977.15 CDW56922.1 - 1.1 9.1 5.8 2.7 7.8 5.8 1.6 1 1 0 1 1 1 0 Septum formation initiator SRPRB PF09439.10 CDW56923.1 - 6.9e-37 126.6 1.1 8.7e-37 126.3 1.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 CDW56923.1 - 3.9e-13 49.2 0.1 5.5e-13 48.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW56923.1 - 6.3e-06 25.7 0.3 1.2e-05 24.8 0.3 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW56923.1 - 0.00017 21.7 0.0 0.00036 20.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 CDW56923.1 - 0.0015 18.1 0.0 0.0028 17.3 0.0 1.5 1 1 0 1 1 1 1 Ras family ATP_bind_1 PF03029.17 CDW56923.1 - 0.0039 17.0 0.6 0.0049 16.7 0.0 1.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 CDW56923.1 - 0.0073 15.5 1.7 0.096 11.8 0.3 2.1 1 1 1 2 2 2 1 G-protein alpha subunit Roc PF08477.13 CDW56923.1 - 0.11 12.7 0.1 0.48 10.7 0.0 2.2 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 CDW56926.1 - 1.7e-85 286.3 0.3 2.3e-85 285.8 0.3 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 CDW56926.1 - 1.4e-06 28.0 0.2 3e-06 26.9 0.2 1.5 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CDW56926.1 - 0.0017 18.7 0.2 0.01 16.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDW56926.1 - 0.0018 18.3 0.0 0.0047 17.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 CDW56926.1 - 0.0021 17.8 0.0 0.004 16.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 CDW56926.1 - 0.0063 16.3 0.1 0.027 14.2 0.1 1.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 CDW56926.1 - 0.011 15.5 0.1 0.023 14.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_10 PF12846.7 CDW56926.1 - 0.014 14.3 0.1 0.086 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_23 PF13476.6 CDW56926.1 - 0.019 15.4 0.0 0.041 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain IIGP PF05049.13 CDW56926.1 - 0.026 13.6 0.0 0.043 12.9 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) NTPase_1 PF03266.15 CDW56926.1 - 0.033 14.1 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 CDW56926.1 - 0.044 14.3 0.0 0.15 12.5 0.0 1.9 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 CDW56926.1 - 0.052 12.9 0.1 0.095 12.0 0.1 1.3 1 0 0 1 1 1 0 KaiC Lant_dehydr_C PF14028.6 CDW56926.1 - 0.053 13.0 0.5 0.13 11.8 0.2 1.7 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term SRP54 PF00448.22 CDW56926.1 - 0.058 13.0 0.1 0.36 10.4 0.1 2.3 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 CDW56926.1 - 0.069 13.4 0.1 0.2 11.9 0.1 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW56926.1 - 0.14 12.7 0.5 0.54 10.8 0.1 2.2 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDW56926.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Raptor_N PF14538.6 CDW56927.1 - 4.1e-67 224.7 0.0 8.2e-67 223.7 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 CDW56927.1 - 0.00011 22.9 8.2 3.8 8.5 0.0 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat HEAT PF02985.22 CDW56927.1 - 0.034 14.4 5.4 0.19 12.1 0.0 4.6 6 0 0 6 6 6 0 HEAT repeat RasGAP PF00616.19 CDW56928.1 - 7.2e-22 78.1 0.7 3e-20 72.8 0.0 3.0 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase VPS9 PF02204.18 CDW56928.1 - 1.9e-20 73.0 0.1 1.7e-19 70.0 0.0 2.5 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain CBFD_NFYB_HMF PF00808.23 CDW56928.1 - 2.3e-13 50.2 0.0 7.8e-13 48.5 0.0 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF5601 PF18151.1 CDW56928.1 - 4.1e-08 33.4 2.2 1.3e-06 28.6 0.4 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF5601) CENP-W PF15510.6 CDW56928.1 - 0.00018 21.7 0.8 0.00065 19.9 0.0 2.3 2 0 0 2 2 2 1 CENP-W protein Forkhead PF00250.18 CDW56929.1 - 8.9e-28 96.4 0.0 3.1e-27 94.7 0.0 1.9 1 0 0 1 1 1 1 Forkhead domain FOXO-TAD PF16676.5 CDW56929.1 - 1e-07 32.2 1.4 2.1e-07 31.2 1.4 1.5 1 0 0 1 1 1 1 Transactivation domain of FOXO protein family SARAF PF06682.12 CDW56929.1 - 0.026 14.2 9.2 0.024 14.3 1.2 2.3 1 1 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis HrcA_DNA-bdg PF03444.15 CDW56929.1 - 0.12 12.1 0.3 0.65 9.7 0.1 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding TMEM51 PF15345.6 CDW56929.1 - 0.21 11.4 10.0 0.4 10.5 10.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 LRR_8 PF13855.6 CDW56930.1 - 3.5e-15 55.5 26.1 1.4e-06 28.0 1.0 5.4 3 2 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 CDW56930.1 - 4.8e-12 45.9 22.9 2e-06 28.0 3.6 5.8 4 2 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDW56930.1 - 6.5e-06 26.0 19.7 1.6 9.6 0.1 7.0 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 CDW56930.1 - 3.4e-05 23.4 5.3 0.27 10.7 0.2 3.7 2 1 3 5 5 5 3 Leucine-rich repeat FNIP PF05725.12 CDW56930.1 - 0.6 10.3 5.9 12 6.2 0.0 3.7 3 1 0 3 3 3 0 FNIP Repeat Guanylate_cyc PF00211.20 CDW56931.1 - 3e-63 212.8 0.0 4.8e-63 212.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 CDW56931.1 - 8.4e-15 54.7 0.0 1.6e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW56931.1 - 2.9e-13 49.8 0.1 2.1e-12 47.0 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain HNOBA PF07701.14 CDW56931.1 - 0.028 13.8 1.0 0.059 12.8 1.0 1.5 1 0 0 1 1 1 0 Heme NO binding associated PBP_like_2 PF12849.7 CDW56931.1 - 0.038 13.7 0.1 0.06 13.0 0.1 1.3 1 0 0 1 1 1 0 PBP superfamily domain RIO1 PF01163.22 CDW56931.1 - 0.047 13.3 0.1 0.094 12.3 0.1 1.4 1 0 0 1 1 1 0 RIO1 family EB PF01683.18 CDW56932.1 - 1.3e-05 25.3 6.0 1.3e-05 25.3 6.0 2.8 3 1 0 3 3 3 1 EB module Exo84_C PF16528.5 CDW56933.1 - 5.4e-36 124.3 1.2 5.4e-36 124.3 1.2 1.7 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps54_N PF10475.9 CDW56933.1 - 0.00061 19.2 0.2 0.0041 16.5 0.0 2.2 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Dor1 PF04124.12 CDW56933.1 - 0.00061 18.6 0.4 0.0027 16.5 0.1 2.1 2 0 0 2 2 2 1 Dor1-like family HSCB_C PF07743.13 CDW56933.1 - 0.056 13.9 3.4 0.22 12.0 1.1 3.1 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain EB PF01683.18 CDW56934.1 - 1.6 9.1 5.4 8.9 6.7 0.1 3.2 3 0 0 3 3 3 0 EB module Actin PF00022.19 CDW56935.1 - 1.4e-151 504.8 0.0 4.5e-151 503.1 0.0 1.6 1 1 0 1 1 1 1 Actin SET PF00856.28 CDW56936.1 - 2.3e-20 73.7 0.2 2.3e-20 73.7 0.2 2.1 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 CDW56936.1 - 1.7e-09 38.3 13.1 1.7e-09 38.3 13.1 2.4 2 0 0 2 2 2 1 Pre-SET motif DUF155 PF02582.14 CDW56937.1 - 1.1e-38 133.0 0.0 1.5e-38 132.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DOT1 PF08123.13 CDW56938.1 - 4.5e-38 130.8 0.0 7.5e-38 130.1 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 PCMT PF01135.19 CDW56938.1 - 0.052 13.3 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DIRP PF06584.13 CDW56939.1 - 9.9e-35 118.9 0.1 3.4e-34 117.2 0.1 2.0 1 0 0 1 1 1 1 DIRP FlgN PF05130.12 CDW56939.1 - 0.0079 16.7 0.1 0.041 14.4 0.1 2.3 1 1 0 1 1 1 1 FlgN protein Exo70 PF03081.15 CDW56939.1 - 0.12 11.4 1.5 0.34 9.9 1.5 1.8 1 1 0 1 1 1 0 Exo70 exocyst complex subunit PX PF00787.24 CDW56939.1 - 0.64 10.0 4.0 0.38 10.8 1.3 2.0 2 0 0 2 2 2 0 PX domain AAA_33 PF13671.6 CDW56940.1 - 1.4e-16 61.0 0.0 2.3e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain SPRY PF00622.28 CDW56940.1 - 1.5e-14 54.1 0.2 2.5e-14 53.4 0.2 1.3 1 0 0 1 1 1 1 SPRY domain Viral_helicase1 PF01443.18 CDW56940.1 - 0.014 15.2 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 CDW56940.1 - 0.17 11.4 0.0 0.48 9.9 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 CDW56940.1 - 0.18 11.1 0.0 2.7 7.2 0.0 2.3 2 1 0 2 2 2 0 Zeta toxin Nup192 PF11894.8 CDW56941.1 - 6.7e-52 176.1 15.2 2.7e-31 107.7 0.0 3.8 3 1 0 3 3 3 3 Nuclear pore complex scaffold, nucleoporins 186/192/205 ATP-synt_ab PF00006.25 CDW56943.1 - 2.1e-108 360.9 0.0 2.7e-108 360.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 CDW56943.1 - 6.5e-42 142.2 0.0 1.1e-41 141.4 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 CDW56943.1 - 0.0017 18.8 1.4 0.0024 18.3 0.2 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain PIP5K PF01504.18 CDW56944.1 - 1.7e-71 240.7 0.0 2.3e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Ribosomal_S21e PF01249.18 CDW56945.1 - 1.4e-32 111.6 0.1 1.6e-32 111.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e ABC_tran PF00005.27 CDW56946.1 - 1.6e-44 151.7 0.0 8.1e-21 75.0 0.0 2.7 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDW56946.1 - 2.6e-20 72.2 4.5 2.6e-20 72.2 4.5 2.9 5 0 0 5 5 2 1 ABC transporter AAA_21 PF13304.6 CDW56946.1 - 4.9e-18 66.0 5.8 7.6e-06 25.9 0.0 5.0 4 1 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW56946.1 - 2.2e-08 33.8 0.1 0.25 10.8 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDW56946.1 - 2.7e-07 30.6 0.0 0.014 15.1 0.0 3.5 3 0 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 CDW56946.1 - 4.6e-06 27.2 0.0 0.068 13.7 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 CDW56946.1 - 1e-05 25.8 0.0 0.026 14.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CDW56946.1 - 2.1e-05 24.7 0.0 0.36 11.0 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CDW56946.1 - 2.9e-05 23.7 0.0 0.29 10.9 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.29 CDW56946.1 - 3.5e-05 24.2 0.0 0.29 11.6 0.0 3.2 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CDW56946.1 - 3.7e-05 23.8 0.0 0.096 12.7 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 CDW56946.1 - 4.6e-05 23.9 0.1 0.11 12.9 0.0 2.9 2 1 0 3 3 2 2 AAA ATPase domain NACHT PF05729.12 CDW56946.1 - 0.00017 21.6 0.0 0.85 9.5 0.0 2.7 2 0 0 2 2 2 2 NACHT domain NB-ARC PF00931.22 CDW56946.1 - 0.00019 20.7 0.0 0.041 13.1 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 CDW56946.1 - 0.00058 20.2 0.0 0.73 10.1 0.1 3.1 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDW56946.1 - 0.00075 19.6 0.0 2.4 8.3 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 CDW56946.1 - 0.001 19.6 8.6 0.039 14.5 0.1 3.6 3 1 0 3 3 3 2 AAA domain AAA_24 PF13479.6 CDW56946.1 - 0.0011 18.8 0.0 0.11 12.2 0.1 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDW56946.1 - 0.0017 18.3 0.0 2 8.3 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase RNA_helicase PF00910.22 CDW56946.1 - 0.0021 18.4 0.0 4 7.9 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_27 PF13514.6 CDW56946.1 - 0.0035 17.0 0.2 1.4 8.5 0.1 2.8 2 1 1 3 3 3 1 AAA domain PduV-EutP PF10662.9 CDW56946.1 - 0.0089 15.8 0.0 2.9 7.6 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 CDW56946.1 - 0.013 15.2 0.0 0.39 10.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 CDW56946.1 - 0.014 15.4 0.4 0.31 11.1 0.0 2.8 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 CDW56946.1 - 0.015 15.2 0.2 1.3 8.9 0.1 2.9 2 1 1 3 3 3 0 NTPase SRP54 PF00448.22 CDW56946.1 - 0.018 14.7 0.1 1.5 8.4 0.2 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_5 PF07728.14 CDW56946.1 - 0.02 14.9 0.0 13 5.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 CDW56946.1 - 0.026 14.9 0.0 9.1 6.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CDW56946.1 - 0.027 14.5 0.0 1.7 8.7 0.0 2.9 2 1 0 2 2 2 0 Dynamin family AAA_13 PF13166.6 CDW56946.1 - 0.031 13.0 0.3 14 4.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain Arf PF00025.21 CDW56946.1 - 0.036 13.5 0.1 14 5.1 0.0 2.8 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_25 PF13481.6 CDW56946.1 - 0.045 13.3 0.0 3.4 7.2 0.0 2.8 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 CDW56946.1 - 0.052 13.5 0.0 3.4 7.5 0.0 2.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 CDW56946.1 - 0.075 12.6 0.0 6.6 6.3 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CDW56946.1 - 0.088 13.0 0.1 13 6.0 0.0 2.9 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 CDW56946.1 - 0.12 12.3 0.0 7 6.5 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain DUF87 PF01935.17 CDW56946.1 - 0.22 11.6 0.7 4.6 7.3 0.0 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain PP_kinase_N PF13089.6 CDW56946.1 - 0.31 11.4 1.7 0.38 11.1 0.3 1.8 2 0 0 2 2 1 0 Polyphosphate kinase N-terminal domain DUF3584 PF12128.8 CDW56946.1 - 3.7 4.9 7.1 0.48 7.9 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) Cadherin PF00028.17 CDW56947.1 - 0 1297.2 0.0 7.3e-19 68.0 0.0 32.4 32 0 0 32 32 32 29 Cadherin domain Laminin_G_2 PF02210.24 CDW56947.1 - 3.8e-31 108.3 0.0 1.8e-13 51.1 0.2 4.3 3 0 0 3 3 3 2 Laminin G domain Cadherin_2 PF08266.12 CDW56947.1 - 2.1e-30 104.4 0.5 0.00032 20.5 0.0 16.5 21 0 0 21 21 21 6 Cadherin-like Laminin_G_1 PF00054.23 CDW56947.1 - 2.8e-21 76.1 0.0 4.8e-11 43.0 0.0 3.1 3 0 0 3 3 3 2 Laminin G domain Cadherin_3 PF16184.5 CDW56947.1 - 6.2e-14 52.0 19.9 5.2 7.1 0.0 15.7 18 0 0 18 18 18 2 Cadherin-like RET_CLD1 PF17756.1 CDW56947.1 - 6.5e-12 45.8 0.0 4 7.7 0.0 12.0 14 0 0 14 14 13 1 RET Cadherin like domain 1 EGF PF00008.27 CDW56947.1 - 1.3e-11 44.6 73.2 0.00032 20.9 9.2 7.2 6 1 0 6 6 6 4 EGF-like domain Cadherin_pro PF08758.11 CDW56947.1 - 1.7e-09 37.7 0.0 1.4 9.1 0.0 8.0 8 0 0 8 8 7 2 Cadherin prodomain like EGF_CA PF07645.15 CDW56947.1 - 4.1e-06 26.9 10.4 4.1e-06 26.9 10.4 5.5 3 2 2 5 5 3 1 Calcium-binding EGF domain He_PIG PF05345.12 CDW56947.1 - 0.00016 21.8 3.0 11 6.3 0.0 6.8 5 0 0 5 5 5 1 Putative Ig domain hEGF PF12661.7 CDW56947.1 - 0.0002 21.9 58.1 0.11 13.2 6.0 6.9 6 0 0 6 6 6 3 Human growth factor-like EGF EGF_2 PF07974.13 CDW56947.1 - 0.0018 18.6 13.3 0.0018 18.6 13.3 6.8 6 1 0 6 6 5 3 EGF-like domain DUF1811 PF08838.10 CDW56947.1 - 0.021 15.0 0.0 7.8 6.8 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1811) Plasmod_Pvs28 PF06247.11 CDW56947.1 - 0.21 11.9 14.2 8.5 6.8 0.1 3.1 2 0 0 2 2 2 0 Pvs28 EGF domain Kelch_1 PF01344.25 CDW56948.1 - 2.4e-64 212.7 18.5 9.5e-18 63.5 2.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 CDW56948.1 - 4.5e-29 99.7 5.3 3.1e-07 30.4 0.1 6.3 1 1 5 6 6 6 6 Kelch motif BACK PF07707.15 CDW56948.1 - 5.4e-29 100.3 1.0 2.2e-28 98.4 0.2 2.3 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 CDW56948.1 - 1.1e-26 93.3 1.4 1.1e-26 93.3 1.4 1.6 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 CDW56948.1 - 1e-19 69.7 10.7 7.8e-07 28.8 0.7 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 CDW56948.1 - 3.1e-11 43.1 9.2 0.00063 19.7 0.0 6.0 5 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_3 PF13415.6 CDW56948.1 - 4e-09 36.5 3.2 0.0017 18.6 0.0 4.6 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 CDW56948.1 - 0.0033 17.4 14.4 0.19 11.7 0.2 5.9 7 0 0 7 7 7 2 Kelch motif DUF4784 PF16023.5 CDW56948.1 - 0.049 12.6 0.1 0.15 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4784) AT_hook PF02178.19 CDW56948.1 - 0.34 10.9 2.3 0.69 10.0 2.3 1.5 1 0 0 1 1 1 0 AT hook motif Mito_morph_reg PF14972.6 CDW56949.1 - 2.1e-44 151.0 0.0 2.5e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial morphogenesis regulator Ig_3 PF13927.6 CDW56950.1 - 1.9e-71 236.7 16.0 9.9e-13 48.5 0.0 7.6 7 0 0 7 7 7 7 Immunoglobulin domain Ig_2 PF13895.6 CDW56950.1 - 2.3e-50 168.8 13.3 7.5e-10 39.0 0.5 7.9 7 1 0 7 7 7 7 Immunoglobulin domain I-set PF07679.16 CDW56950.1 - 8.1e-49 163.7 3.9 1.2e-12 47.8 0.0 9.2 7 3 0 7 7 7 6 Immunoglobulin I-set domain ig PF00047.25 CDW56950.1 - 6.2e-34 116.0 10.9 7.7e-07 29.2 0.0 8.8 7 4 0 7 7 7 6 Immunoglobulin domain V-set PF07686.17 CDW56950.1 - 1.2e-23 83.4 13.8 0.00029 21.0 0.1 11.0 8 3 2 10 10 10 6 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW56950.1 - 2.2e-20 72.5 9.5 2.3e-10 40.4 0.3 6.1 6 0 0 6 6 6 2 CD80-like C2-set immunoglobulin domain fn3 PF00041.21 CDW56950.1 - 2.3e-09 37.4 0.1 1.3e-08 35.1 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain Ig_6 PF18452.1 CDW56950.1 - 4.1e-09 35.9 0.0 0.88 9.2 0.0 5.9 5 0 0 5 5 5 2 Immunoglobulin domain V-set_CD47 PF08204.11 CDW56950.1 - 1.6e-07 31.4 0.1 1.1 9.3 0.0 5.0 6 0 0 6 6 6 2 CD47 immunoglobulin-like domain C1-set PF07654.15 CDW56950.1 - 3.4e-07 30.5 3.3 0.11 12.9 0.1 5.7 6 0 0 6 6 6 1 Immunoglobulin C1-set domain Ig_4 PF16680.5 CDW56950.1 - 6.8e-05 23.1 0.0 1.1 9.6 0.0 5.3 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Pur_ac_phosph_N PF16656.5 CDW56950.1 - 0.0013 19.2 0.1 0.18 12.4 0.0 3.2 3 0 0 3 3 2 1 Purple acid Phosphatase, N-terminal domain PRIMA1 PF16101.5 CDW56950.1 - 0.11 12.5 0.5 0.4 10.7 0.5 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Chromate_transp PF02417.15 CDW56950.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.3 1 0 0 1 1 1 0 Chromate transporter GIDA PF01134.22 CDW56952.1 - 3.5e-142 474.1 0.0 5.8e-142 473.4 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CDW56952.1 - 9.1e-61 205.7 0.0 1.3e-60 205.2 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 CDW56952.1 - 3e-06 26.9 0.2 4.9e-06 26.2 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDW56952.1 - 4.3e-05 22.9 0.3 0.00091 18.5 0.2 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDW56952.1 - 0.00012 21.3 0.4 0.00019 20.6 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CDW56952.1 - 0.00075 18.7 0.1 0.0038 16.3 0.1 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 CDW56952.1 - 0.0018 18.8 0.2 0.005 17.4 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CDW56952.1 - 0.015 14.6 0.5 0.025 13.9 0.0 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 CDW56952.1 - 0.019 13.7 0.8 0.17 10.5 0.1 2.4 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.6 CDW56952.1 - 0.1 11.8 0.0 0.52 9.5 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase LRR_8 PF13855.6 CDW56953.1 - 3.3e-32 110.1 32.7 3.9e-10 39.3 6.3 6.1 4 1 2 6 6 6 4 Leucine rich repeat LRR_5 PF13306.6 CDW56953.1 - 2.2e-16 60.0 0.4 3.4e-08 33.5 0.1 2.8 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 CDW56953.1 - 4.2e-14 52.4 40.8 3.5e-05 24.1 5.8 7.3 6 1 3 9 9 9 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CDW56953.1 - 1.8e-07 30.8 17.2 0.0012 18.3 3.4 3.8 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 CDW56953.1 - 0.093 13.3 31.0 3.2 8.7 0.1 8.9 7 2 1 8 8 8 0 Leucine Rich Repeat Lectin_C PF00059.21 CDW56955.1 - 6e-09 36.6 0.6 1.3e-08 35.5 0.6 1.6 1 0 0 1 1 1 1 Lectin C-type domain CLN3 PF02487.17 CDW56955.1 - 0.076 12.1 0.3 0.11 11.6 0.3 1.1 1 0 0 1 1 1 0 CLN3 protein DUF5385 PF17359.2 CDW56955.1 - 0.092 12.3 0.5 0.16 11.5 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) CBM_21 PF03370.13 CDW56956.1 - 3e-32 111.1 0.3 4.6e-32 110.5 0.3 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 CDW56956.1 - 5.9e-11 42.8 0.3 1.4e-10 41.6 0.3 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) MFS_1 PF07690.16 CDW56957.1 - 1.5e-40 139.2 35.0 7.3e-23 81.0 11.2 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Nuc_H_symport PF03825.16 CDW56957.1 - 1.2e-06 27.8 10.4 1.2e-06 27.8 10.4 2.3 3 0 0 3 3 3 1 Nucleoside H+ symporter Tetraspanin PF00335.20 CDW56958.1 - 4.6e-36 124.7 15.9 5.5e-36 124.4 15.9 1.1 1 0 0 1 1 1 1 Tetraspanin family TMEM238 PF15125.6 CDW56958.1 - 0.019 15.2 0.4 0.019 15.2 0.4 2.7 3 0 0 3 3 3 0 TMEM238 protein family Phage_holin_3_7 PF05449.11 CDW56958.1 - 0.46 10.5 5.0 0.74 9.9 1.3 2.7 3 0 0 3 3 3 0 Putative 3TM holin, Phage_holin_3 DUF2981 PF11200.8 CDW56958.1 - 1.8 8.2 3.5 3.3 7.4 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Forkhead PF00250.18 CDW56959.1 - 5.8e-37 125.8 0.3 1.1e-36 125.0 0.3 1.4 1 0 0 1 1 1 1 Forkhead domain Yop-YscD_cpl PF16697.5 CDW56959.1 - 0.034 14.5 0.0 0.072 13.4 0.0 1.5 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Linker_histone PF00538.19 CDW56959.1 - 0.14 12.6 0.1 0.48 10.8 0.1 1.9 1 0 0 1 1 1 0 linker histone H1 and H5 family zf-AN1 PF01428.16 CDW56960.1 - 6e-10 39.1 7.1 6e-10 39.1 7.1 2.6 2 2 0 2 2 2 1 AN1-like Zinc finger Ribosomal_S14 PF00253.21 CDW56960.1 - 0.15 11.9 0.2 0.15 11.9 0.2 2.9 2 1 0 2 2 2 0 Ribosomal protein S14p/S29e Nebulin PF00880.18 CDW56963.1 - 7.6e-16 57.7 0.8 9.2e-08 31.8 0.1 2.5 2 0 0 2 2 2 2 Nebulin repeat LIM PF00412.22 CDW56963.1 - 3e-11 43.4 8.3 5.4e-11 42.6 8.3 1.4 1 0 0 1 1 1 1 LIM domain SH3_9 PF14604.6 CDW56963.1 - 8.6e-07 28.7 0.2 1.5e-06 27.9 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW56963.1 - 3.6e-06 26.5 0.4 7.3e-06 25.5 0.4 1.6 1 0 0 1 1 1 1 SH3 domain RIFIN PF02009.16 CDW56963.1 - 0.29 11.0 4.5 0.13 12.1 1.9 1.7 2 0 0 2 2 2 0 Rifin DNA_pol_B_palm PF14792.6 CDW56964.1 - 1e-32 112.7 0.1 2e-32 111.7 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 CDW56964.1 - 3.1e-21 75.0 0.4 4.5e-20 71.2 0.1 2.7 3 0 0 3 3 3 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 CDW56964.1 - 1.4e-13 51.0 0.1 3.4e-13 49.7 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain BRCT_2 PF16589.5 CDW56964.1 - 3e-07 30.7 0.0 5.9e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DNA_pol_B_thumb PF14791.6 CDW56964.1 - 7.5e-05 22.8 0.0 0.00029 20.9 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase beta thumb HHH_5 PF14520.6 CDW56964.1 - 0.0006 20.4 0.0 1.5 9.5 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix domain IMS_HHH PF11798.8 CDW56964.1 - 0.0057 16.9 0.2 1.6 9.2 0.0 3.0 2 0 0 2 2 2 1 IMS family HHH motif HHH_2 PF12826.7 CDW56964.1 - 0.01 15.9 0.0 0.039 14.1 0.0 2.0 1 0 0 1 1 1 0 Helix-hairpin-helix motif NTP_transf_2 PF01909.23 CDW56964.1 - 0.043 14.1 0.8 0.14 12.4 0.1 2.3 3 0 0 3 3 3 0 Nucleotidyltransferase domain HHH_3 PF12836.7 CDW56964.1 - 0.052 13.8 0.0 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix motif BRCT PF00533.26 CDW56964.1 - 0.056 13.8 0.1 0.14 12.5 0.1 1.8 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Ribosomal_L30 PF00327.20 CDW56964.1 - 0.088 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L30p/L7e Bombinin PF05298.11 CDW56964.1 - 0.19 11.4 0.3 1.3 8.8 0.1 2.1 1 1 1 2 2 2 0 Bombinin Foie-gras_1 PF11817.8 CDW56965.1 - 3.9e-40 138.1 1.7 6.4e-40 137.4 1.7 1.4 1 0 0 1 1 1 1 Foie gras liver health family 1 Ribosomal_S14 PF00253.21 CDW56965.1 - 7e-13 48.1 3.4 7e-13 48.1 3.4 2.1 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Endonuc-BglII PF09195.11 CDW56965.1 - 0.15 11.9 0.0 0.42 10.4 0.0 1.7 1 0 0 1 1 1 0 Restriction endonuclease BglII MscS_TM PF12794.7 CDW56966.1 - 5.8e-116 387.1 15.0 1.1e-115 386.2 15.0 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 MS_channel PF00924.18 CDW56966.1 - 6e-54 182.7 0.7 6e-54 182.7 0.7 1.9 2 0 0 2 2 2 1 Mechanosensitive ion channel AA_permease_2 PF13520.6 CDW56968.1 - 2e-23 82.9 44.9 2.8e-23 82.5 44.9 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW56968.1 - 1.4e-10 40.4 43.2 5.3e-10 38.5 43.3 1.9 1 1 0 1 1 1 1 Amino acid permease Tubulin PF00091.25 CDW56968.1 - 0.12 12.6 0.1 0.16 12.1 0.1 1.2 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain DUF3693 PF12472.8 CDW56968.1 - 7.5 6.3 6.5 10 5.9 0.0 3.6 4 1 1 5 5 5 0 Phage related protein tRNA-synt_2 PF00152.20 CDW56969.1 - 3.8e-47 160.9 0.0 6.9e-47 160.0 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) Transgly PF00912.22 CDW56969.1 - 0.15 11.5 0.0 0.37 10.2 0.0 1.6 2 0 0 2 2 2 0 Transglycosylase FAD_binding_2 PF00890.24 CDW56970.1 - 1.4e-101 340.6 0.4 1.4e-101 340.6 0.4 1.8 2 0 0 2 2 2 1 FAD binding domain Succ_DH_flav_C PF02910.20 CDW56970.1 - 5.8e-39 133.0 0.1 9.4e-39 132.3 0.1 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 CDW56970.1 - 0.0012 18.1 0.0 0.014 14.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_8 PF13183.6 CDW56971.1 - 2.5e-12 47.1 1.9 3.9e-12 46.4 1.9 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDW56971.1 - 2e-11 43.8 1.8 3.4e-11 43.1 1.8 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDW56971.1 - 2e-09 37.8 12.7 2.9e-07 30.9 4.1 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer2_3 PF13085.6 CDW56971.1 - 1.9e-08 34.3 0.0 3.8e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 CDW56971.1 - 1.3e-07 32.1 12.3 1.9e-06 28.4 3.5 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDW56971.1 - 2.2e-07 31.0 2.7 0.0011 19.1 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDW56971.1 - 7.2e-07 29.4 0.8 0.0051 17.0 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDW56971.1 - 1.3e-06 29.2 1.8 3e-06 28.1 1.8 1.6 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4 PF00037.27 CDW56971.1 - 1.6e-05 24.5 8.4 0.00023 20.8 1.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 CDW56971.1 - 0.0012 19.3 3.3 0.0098 16.4 0.2 2.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_4 PF12800.7 CDW56971.1 - 0.0017 18.7 1.7 0.0017 18.7 1.7 2.1 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_21 PF14697.6 CDW56971.1 - 0.0025 17.9 7.8 0.056 13.6 7.8 2.2 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDW56971.1 - 0.0035 18.2 11.5 0.073 14.0 3.7 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CDW56971.1 - 0.0036 17.3 1.7 0.0036 17.3 1.7 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 CDW56971.1 - 0.0068 16.4 2.6 0.0068 16.4 2.6 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_22 PF17179.4 CDW56971.1 - 0.0077 17.1 3.7 0.86 10.5 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.6 CDW56971.1 - 0.03 15.0 1.8 1.9 9.3 0.1 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain Beta-lactamase PF00144.24 CDW56972.1 - 2.9e-60 204.3 0.1 4.1e-60 203.8 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase Lipocalin_2 PF08212.12 CDW56972.1 - 1.7e-44 151.3 0.0 2.3e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 CDW56972.1 - 3.2e-08 33.9 0.0 6.6e-08 32.9 0.0 1.5 2 0 0 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family VDE PF07137.11 CDW56972.1 - 0.15 11.5 0.0 17 4.8 0.0 2.2 2 0 0 2 2 2 0 VDE lipocalin domain YjeJ PF15922.5 CDW56973.1 - 9.6e-154 510.6 3.7 1.3e-153 510.2 3.7 1.1 1 0 0 1 1 1 1 YjeJ-like Radical_SAM PF04055.21 CDW56973.1 - 5.8e-08 33.3 0.0 2.3e-07 31.3 0.0 2.0 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CDW56973.1 - 6.8e-06 26.2 0.0 0.00012 22.2 0.0 3.1 4 0 0 4 4 4 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 CDW56973.1 - 2.1e-05 24.8 0.0 4.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Cpn60_TCP1 PF00118.24 CDW56974.1 - 1.5e-94 317.4 19.7 2.4e-94 316.7 19.7 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn10 PF00166.21 CDW56975.1 - 3.8e-30 103.8 1.2 4.1e-30 103.7 1.2 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit AA_permease_2 PF13520.6 CDW56976.1 - 3.2e-30 105.3 37.0 4.3e-30 104.9 37.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW56976.1 - 3e-08 32.7 35.2 5.7e-08 31.8 35.2 1.4 1 1 0 1 1 1 1 Amino acid permease IstB_IS21 PF01695.17 CDW56976.1 - 0.16 11.7 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein FxsA PF04186.13 CDW56977.1 - 3.9e-15 55.9 1.5 4.7e-15 55.7 1.5 1.1 1 0 0 1 1 1 1 FxsA cytoplasmic membrane protein Lyase_1 PF00206.20 CDW56978.1 - 2.8e-115 385.0 0.0 3.4e-115 384.7 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CDW56978.1 - 1.3e-17 63.9 0.0 3.9e-17 62.4 0.0 1.9 1 0 0 1 1 1 1 Fumarase C C-terminus DcuA_DcuB PF03605.14 CDW56979.1 - 3.5e-145 483.5 24.4 4.2e-145 483.3 24.4 1.1 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter CutA1 PF03091.15 CDW56980.1 - 1.5e-20 72.9 0.3 1.7e-20 72.7 0.3 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein TetR_C_31 PF17940.1 CDW56981.1 - 0.06 13.5 1.4 0.56 10.4 0.4 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain CadC_C1 PF18500.1 CDW56982.1 - 5.4e-73 243.5 1.3 1.1e-72 242.5 1.3 1.5 1 0 0 1 1 1 1 CadC C-terminal domain 1 Trans_reg_C PF00486.28 CDW56982.1 - 9.3e-19 67.3 0.0 1.9e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal TPR_2 PF07719.17 CDW56982.1 - 0.037 14.1 0.1 0.17 12.0 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat AA_permease_2 PF13520.6 CDW56983.1 - 8.7e-38 130.2 56.2 1.9e-37 129.1 56.2 1.5 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW56983.1 - 1.1e-19 70.4 46.6 3.5e-19 68.7 46.7 1.6 1 1 0 1 1 1 1 Amino acid permease OKR_DC_1 PF01276.20 CDW56984.1 - 4.2e-199 661.5 0.2 6.2e-199 661.0 0.2 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain OKR_DC_1_C PF03711.15 CDW56984.1 - 5.6e-46 156.1 1.4 1.3e-45 155.0 0.9 1.9 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, C-terminal domain OKR_DC_1_N PF03709.15 CDW56984.1 - 2.3e-29 101.9 0.1 4.7e-29 100.9 0.1 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain Ish1 PF10281.9 CDW56984.1 - 0.15 12.4 0.1 8 6.9 0.0 2.9 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein PTR2 PF00854.21 CDW56985.1 - 5.8e-91 305.3 18.3 7.2e-91 305.0 18.3 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 CDW56985.1 - 6e-19 68.2 43.1 6e-19 68.2 43.1 3.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4271 PF14093.6 CDW56985.1 - 0.027 14.4 0.1 0.027 14.4 0.1 4.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4271) tRNA-synt_2 PF00152.20 CDW56986.1 - 2.7e-84 282.9 0.4 3.8e-84 282.4 0.4 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CDW56986.1 - 6.8e-16 58.0 0.0 1.2e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CDW56986.1 - 1.5e-05 24.7 2.3 0.026 14.0 0.2 3.2 3 1 0 3 3 3 2 tRNA synthetases class II core domain (F) DUF2333 PF10095.9 CDW56986.1 - 0.1 11.6 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) sCache_3_2 PF17203.4 CDW56987.1 - 4e-23 82.1 1.5 8.5e-22 77.8 0.2 2.8 2 1 0 2 2 2 1 Single cache domain 3 HATPase_c PF02518.26 CDW56987.1 - 3.5e-19 69.4 0.0 1e-18 67.8 0.0 1.8 2 0 0 2 2 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS PF00989.25 CDW56987.1 - 7e-15 55.0 0.1 4.7e-14 52.4 0.1 2.2 2 0 0 2 2 2 1 PAS fold SPOB_a PF14689.6 CDW56987.1 - 1.6e-10 40.5 0.7 1.6e-10 40.5 0.7 2.0 2 0 0 2 2 2 1 Sensor_kinase_SpoOB-type, alpha-helical domain HATPase_c_5 PF14501.6 CDW56987.1 - 1.7e-09 37.5 0.0 1.2e-07 31.6 0.0 2.6 3 0 0 3 3 3 1 GHKL domain dCache_1 PF02743.18 CDW56987.1 - 1.6e-06 28.1 1.0 2.6e-05 24.2 0.0 2.6 3 0 0 3 3 3 1 Cache domain PAS_10 PF13596.6 CDW56987.1 - 2.9e-06 27.8 0.1 8.6e-06 26.3 0.0 1.8 2 0 0 2 2 1 1 PAS domain sCache_3_3 PF17202.4 CDW56987.1 - 7.2e-06 26.4 0.0 0.086 13.3 0.0 2.3 2 0 0 2 2 2 2 Single cache domain 3 dCache_3 PF14827.6 CDW56987.1 - 8.9e-06 25.5 0.1 0.033 13.8 0.0 2.5 2 0 0 2 2 2 2 Double sensory domain of two-component sensor kinase PAS_8 PF13188.7 CDW56987.1 - 1.2e-05 25.2 0.0 3.4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 PAS domain HATPase_c_2 PF13581.6 CDW56987.1 - 1.8e-05 24.7 0.0 4.1e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain PAS_9 PF13426.7 CDW56987.1 - 0.00012 22.3 0.0 0.00027 21.1 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDW56987.1 - 0.00087 19.5 0.2 0.049 13.9 0.1 3.0 2 1 0 2 2 2 1 PAS fold HATPase_c_3 PF13589.6 CDW56987.1 - 0.0094 15.8 0.0 0.019 14.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_7 PF12860.7 CDW56987.1 - 0.046 13.9 0.1 0.35 11.0 0.1 2.2 1 1 0 1 1 1 0 PAS fold LrgB PF04172.16 CDW56987.1 - 0.13 11.8 2.7 0.55 9.7 0.1 2.2 2 0 0 2 2 2 0 LrgB-like family DUF996 PF06195.13 CDW56987.1 - 3.5 7.9 8.2 12 6.2 0.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF996) Response_reg PF00072.24 CDW56988.1 - 1.1e-14 54.6 0.0 1.5e-14 54.1 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain CitT PF12431.8 CDW56988.1 - 0.029 14.7 0.2 0.058 13.8 0.2 1.5 1 0 0 1 1 1 0 Transcriptional regulator EcoRII-N PF09217.10 CDW56988.1 - 0.053 13.3 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease EcoRII, N-terminal HTH_11 PF08279.12 CDW56988.1 - 0.081 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 HTH domain DcuA_DcuB PF03605.14 CDW56989.1 - 2.2e-149 497.3 18.5 2.6e-149 497.1 18.5 1.0 1 0 0 1 1 1 1 Anaerobic c4-dicarboxylate membrane transporter Fumerase_C PF05683.12 CDW56990.1 - 3.3e-89 297.7 0.0 6.4e-89 296.7 0.0 1.5 1 0 0 1 1 1 1 Fumarase C-terminus Fumerase PF05681.14 CDW56990.1 - 5.4e-88 294.9 0.0 6.8e-88 294.6 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) DUF2238 PF09997.9 CDW56991.1 - 7e-57 191.1 1.4 8.7e-57 190.8 1.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2238) MFS_2 PF13347.6 CDW56992.1 - 4.3e-68 229.8 29.6 5.3e-68 229.5 29.6 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 CDW56992.1 - 0.0091 15.0 44.4 0.052 12.5 15.2 2.6 1 1 0 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_4 PF02056.16 CDW56993.1 - 2.8e-81 271.4 0.1 3.8e-81 271.0 0.1 1.2 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase Glyco_hydro_4C PF11975.8 CDW56993.1 - 6.2e-64 215.9 0.1 8.4e-64 215.5 0.1 1.2 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase C-terminal domain HTH_AraC PF00165.23 CDW56994.1 - 5.5e-23 80.5 0.3 1.4e-11 44.2 0.2 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 CDW56994.1 - 3.4e-19 68.9 0.1 7.1e-19 67.9 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Cupin_2 PF07883.11 CDW56994.1 - 0.0041 16.8 0.1 0.0071 16.0 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Rrf2 PF02082.20 CDW56994.1 - 0.08 13.3 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator AraC_binding PF02311.19 CDW56994.1 - 0.13 12.2 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 AraC-like ligand binding domain OKR_DC_1 PF01276.20 CDW56995.1 - 1.6e-196 653.0 0.0 2e-196 652.7 0.0 1.1 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain OKR_DC_1_C PF03711.15 CDW56995.1 - 2.6e-42 144.2 0.0 5.9e-42 143.1 0.0 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, C-terminal domain OKR_DC_1_N PF03709.15 CDW56995.1 - 2.6e-25 88.8 0.0 5e-25 87.9 0.0 1.5 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain Pyridoxal_deC PF00282.19 CDW56995.1 - 7.9e-06 24.8 0.0 1.3e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 CDW56995.1 - 0.0046 16.2 0.0 0.0085 15.3 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Late_protein_L1 PF00500.18 CDW56995.1 - 0.058 12.2 0.0 0.39 9.5 0.0 1.9 2 0 0 2 2 2 0 L1 (late) protein AA_permease_2 PF13520.6 CDW56996.1 - 5.3e-50 170.5 54.8 6.6e-50 170.2 54.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW56996.1 - 5.8e-33 114.2 50.1 1.3e-32 113.1 49.6 1.5 1 1 0 1 1 1 1 Amino acid permease Sulfatase PF00884.23 CDW56997.1 - 1.6e-53 182.1 0.3 2.4e-53 181.6 0.3 1.3 1 0 0 1 1 1 1 Sulfatase EptA_B_N PF08019.12 CDW56997.1 - 1.7e-42 144.9 9.5 1.7e-42 144.9 9.5 2.5 3 0 0 3 3 3 1 Phosphoethanolamine transferase EptA/EptB Response_reg PF00072.24 CDW56997.1 - 1.1e-20 73.9 0.0 3.3e-20 72.3 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CDW56997.1 - 8.2e-18 65.0 0.0 1.6e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Trans_reg_C PF00486.28 CDW56997.1 - 2.4e-14 53.2 0.1 9e-14 51.3 0.1 2.1 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal HisKA PF00512.25 CDW56997.1 - 9e-09 35.2 0.7 4.3e-08 33.1 0.7 2.3 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDW56997.1 - 0.0015 18.9 2.0 0.0033 17.8 0.8 2.3 2 0 0 2 2 2 1 HAMP domain NPFF PF15085.6 CDW56997.1 - 0.063 13.6 0.4 22 5.4 0.0 2.8 2 0 0 2 2 2 0 Neuropeptide FF AAA_33 PF13671.6 CDW56997.1 - 0.094 12.9 0.1 27 4.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain Rhomboid PF01694.22 CDW56997.1 - 0.68 9.9 5.7 1.4 8.9 5.7 1.5 1 0 0 1 1 1 0 Rhomboid family Sugar_tr PF00083.24 CDW56998.1 - 6.6e-76 256.0 24.0 9e-76 255.5 24.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CDW56998.1 - 6.4e-36 124.0 40.0 1e-25 90.4 15.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Osmo_CC PF08946.10 CDW56998.1 - 1.6e-22 79.5 7.6 2.7e-22 78.8 7.6 1.4 1 0 0 1 1 1 1 Osmosensory transporter coiled coil CM_2 PF01817.21 CDW56998.1 - 0.037 14.4 0.4 0.07 13.5 0.4 1.4 1 0 0 1 1 1 0 Chorismate mutase type II Prefoldin PF02996.17 CDW56998.1 - 0.072 13.0 0.6 0.12 12.3 0.6 1.3 1 0 0 1 1 1 0 Prefoldin subunit DUF1043 PF06295.12 CDW56998.1 - 0.2 11.7 0.0 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) T3SSipB PF16535.5 CDW56998.1 - 0.23 12.0 0.2 0.35 11.3 0.2 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB TRI12 PF06609.13 CDW56998.1 - 1.2 7.4 17.0 0.03 12.8 8.1 2.1 1 1 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) YjcZ PF13990.6 CDW56999.1 - 4.6e-126 419.8 4.5 5.1e-126 419.6 4.5 1.0 1 0 0 1 1 1 1 YjcZ-like protein Dynamin_N PF00350.23 CDW57000.1 - 1.8e-18 67.1 0.0 6.2e-18 65.4 0.0 1.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CDW57000.1 - 6.4e-08 32.7 0.0 6.8e-07 29.4 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF1397 PF07165.11 CDW57000.1 - 0.0099 15.3 0.2 2.6 7.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1397) GTP_EFTU PF00009.27 CDW57000.1 - 0.011 15.3 0.0 1 8.9 0.0 2.7 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CDW57000.1 - 0.013 16.0 0.9 1.8 9.1 0.1 3.6 4 0 0 4 4 4 0 ABC transporter AIG1 PF04548.16 CDW57000.1 - 0.017 14.4 0.1 0.069 12.5 0.0 2.0 2 0 0 2 2 2 0 AIG1 family NYD-SP28_assoc PF14775.6 CDW57000.1 - 0.11 12.6 2.2 0.13 12.4 0.3 2.3 2 0 0 2 2 2 0 Sperm tail C-terminal domain Mating_N PF12731.7 CDW57000.1 - 0.16 12.1 8.2 0.23 11.6 0.9 3.0 3 0 0 3 3 3 0 Mating-type protein beta 1 Spore_IV_A PF09547.10 CDW57000.1 - 0.17 10.8 0.0 0.4 9.6 0.0 1.6 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) Exonuc_VII_L PF02601.15 CDW57000.1 - 8.2 5.9 10.8 14 5.1 4.0 2.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit PhnA PF03831.14 CDW57001.1 - 4e-35 119.5 4.5 4.8e-35 119.3 4.5 1.1 1 0 0 1 1 1 1 PhnA domain PhnA_Zn_Ribbon PF08274.12 CDW57001.1 - 1.4e-15 56.9 7.1 2.2e-15 56.3 7.1 1.3 1 0 0 1 1 1 1 PhnA Zinc-Ribbon TF_Zn_Ribbon PF08271.12 CDW57001.1 - 1.1e-05 24.8 1.8 1.1e-05 24.8 1.8 1.8 2 1 0 2 2 2 1 TFIIB zinc-binding zf-RRN7 PF11781.8 CDW57001.1 - 1.7e-05 24.4 0.9 3.4e-05 23.4 0.9 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 A2L_zn_ribbon PF08792.10 CDW57001.1 - 0.0047 16.6 1.5 0.0087 15.8 1.5 1.4 1 0 0 1 1 1 1 A2L zinc ribbon domain PADR1 PF08063.12 CDW57001.1 - 0.014 15.1 3.1 0.027 14.3 3.1 1.4 1 0 0 1 1 1 0 PADR1 (NUC008) domain zinc-ribbons_6 PF07191.12 CDW57001.1 - 0.031 14.3 0.8 0.047 13.7 0.8 1.3 1 0 0 1 1 1 0 zinc-ribbons Zn_Tnp_IS1595 PF12760.7 CDW57001.1 - 0.055 13.4 1.5 0.099 12.6 1.5 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain HypA PF01155.19 CDW57001.1 - 0.11 12.5 0.3 0.22 11.5 0.3 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OrfB_Zn_ribbon PF07282.11 CDW57001.1 - 0.16 11.9 0.8 0.29 11.1 0.8 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain TFIIS_C PF01096.18 CDW57001.1 - 0.38 10.6 4.2 7.4 6.5 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) UPF0547 PF10571.9 CDW57001.1 - 0.43 10.7 5.0 0.71 10.0 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf_C2H2_10 PF18414.1 CDW57001.1 - 1.1 8.9 5.0 10 5.8 0.9 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger zinc_ribbon_4 PF13717.6 CDW57001.1 - 3.2 7.8 6.1 62 3.6 6.1 2.5 1 1 0 1 1 1 0 zinc-ribbon domain Zn_ribbon_SprT PF17283.2 CDW57001.1 - 6.7 6.7 6.0 17 5.4 1.0 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Thermopsin PF05317.11 CDW57002.1 - 0.12 11.9 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Thermopsin Pkinase_Tyr PF07714.17 CDW57003.1 - 9.1e-90 300.4 0.0 1.4e-89 299.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW57003.1 - 1e-43 149.6 0.0 2.3e-43 148.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Ephrin_lbd PF01404.19 CDW57003.1 - 1.2e-40 139.5 0.1 2.1e-40 138.6 0.1 1.5 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain fn3 PF00041.21 CDW57003.1 - 9.4e-14 51.5 3.8 6.2e-09 36.1 0.2 4.6 5 0 0 5 5 5 2 Fibronectin type III domain EphA2_TM PF14575.6 CDW57003.1 - 2e-11 44.6 0.0 4.2e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SAM_2 PF07647.17 CDW57003.1 - 0.00084 19.4 0.0 0.002 18.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ephrin_rec_like PF07699.13 CDW57003.1 - 0.0012 18.6 5.3 0.0012 18.6 5.3 2.8 2 1 1 3 3 3 1 Putative ephrin-receptor like Haspin_kinase PF12330.8 CDW57003.1 - 0.0022 17.0 0.0 0.0039 16.2 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain SAM_1 PF00536.30 CDW57003.1 - 0.012 16.0 0.0 0.026 15.0 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pur_ac_phosph_N PF16656.5 CDW57003.1 - 0.042 14.4 0.5 0.98 10.0 0.1 3.0 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Kdo PF06293.14 CDW57003.1 - 0.046 13.1 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW57003.1 - 0.073 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Gram_pos_anchor PF00746.21 CDW57003.1 - 0.096 12.6 0.2 0.16 11.9 0.2 1.3 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Kinase-like PF14531.6 CDW57003.1 - 0.14 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 CDW57003.1 - 0.22 11.4 0.0 0.43 10.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Oxysterol_BP PF01237.18 CDW57004.1 - 8.4e-129 429.6 1.8 1.2e-128 429.1 1.8 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 CDW57004.1 - 1.1e-16 61.3 0.2 2.6e-16 60.0 0.2 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CDW57004.1 - 7.1e-10 39.0 0.1 1.6e-09 37.9 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 CDW57004.1 - 5e-06 26.9 5.9 0.0012 19.3 5.9 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 CDW57004.1 - 0.045 14.0 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain Selenoprotein_S PF06936.11 CDW57004.1 - 1.8 8.4 7.6 1.4 8.7 2.8 2.5 2 0 0 2 2 2 0 Selenoprotein S (SelS) ATP_bind_1 PF03029.17 CDW57006.1 - 2.3e-50 171.6 0.0 6.4e-42 144.0 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein C2 PF00168.30 CDW57006.1 - 4e-38 129.8 0.2 2.4e-24 85.6 0.0 2.8 2 0 0 2 2 2 2 C2 domain RrnaAD PF00398.20 CDW57006.1 - 1.3e-20 73.6 0.0 3.7e-20 72.1 0.0 1.7 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase SMP_LBD PF17047.5 CDW57006.1 - 8.1e-20 71.0 0.1 3.1e-15 56.1 0.0 2.6 1 1 1 2 2 2 2 Synaptotagmin-like mitochondrial-lipid-binding domain FPL PF09758.9 CDW57006.1 - 2.1e-19 70.0 2.9 4.7e-09 36.4 0.0 3.8 1 1 2 3 3 3 3 Uncharacterised conserved protein AAA_16 PF13191.6 CDW57006.1 - 0.0023 18.3 0.0 0.0076 16.6 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CDW57006.1 - 0.0042 17.6 0.1 0.025 15.1 0.0 2.3 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CDW57006.1 - 0.0052 16.7 0.0 0.019 14.9 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 CDW57006.1 - 0.025 14.1 0.0 0.049 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region 6PF2K PF01591.18 CDW57006.1 - 0.065 12.5 0.0 0.19 11.0 0.0 1.7 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_24 PF13479.6 CDW57006.1 - 0.096 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CDW57006.1 - 0.11 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Roc PF08477.13 CDW57006.1 - 0.12 12.6 0.0 0.54 10.5 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 CDW57006.1 - 0.14 12.3 0.0 0.34 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDW57006.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) cobW PF02492.19 CDW57006.1 - 0.16 11.5 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 CDW57007.1 - 1.1e-50 171.9 0.0 1.6e-50 171.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CDW57007.1 - 1.4e-34 118.5 1.7 2.5e-34 117.6 1.7 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CDW57007.1 - 2.1e-18 66.1 0.0 4.4e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 CDW57007.1 - 2e-06 27.9 0.0 3.6e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 CDW57007.1 - 0.00033 20.5 0.0 0.00079 19.3 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain Ras PF00071.22 CDW57007.1 - 0.00041 20.0 0.0 0.00072 19.2 0.0 1.4 1 0 0 1 1 1 1 Ras family EFG_II PF14492.6 CDW57007.1 - 0.0014 18.7 0.0 0.01 15.9 0.0 2.5 2 1 0 2 2 2 1 Elongation Factor G, domain II SRPRB PF09439.10 CDW57007.1 - 0.0016 17.9 0.0 0.0039 16.6 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU_D2 PF03144.25 CDW57007.1 - 0.0017 18.7 0.0 0.0074 16.7 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CDW57007.1 - 0.022 14.7 0.0 0.26 11.2 0.0 2.2 1 1 1 2 2 2 0 RsgA GTPase TniB PF05621.11 CDW57007.1 - 0.032 13.6 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein PilS PF08805.11 CDW57007.1 - 0.19 11.6 0.0 0.43 10.4 0.0 1.6 1 0 0 1 1 1 0 PilS N terminal Rx_N PF18052.1 CDW57008.1 - 0.031 14.5 0.0 8.7 6.7 0.0 2.1 2 0 0 2 2 2 0 Rx N-terminal domain Leucyl-specific PF14795.6 CDW57008.1 - 0.035 14.2 0.0 8.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain DUF2854 PF11016.8 CDW57008.1 - 0.036 14.0 0.8 1.5 8.8 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2854) DUF2255 PF10012.9 CDW57008.1 - 0.084 13.0 0.1 1.5 9.0 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2255) DUF3843 PF12954.7 CDW57008.1 - 0.4 9.6 2.9 2.9 6.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3843) ERCC3_RAD25_C PF16203.5 CDW57009.1 - 2.7e-119 396.9 3.8 4.6e-119 396.1 3.8 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 CDW57009.1 - 3.4e-36 124.2 0.0 6.7e-36 123.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW57009.1 - 1.4e-15 57.7 0.0 2.9e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDW57009.1 - 3.9e-13 49.7 0.6 1.3e-12 48.0 0.2 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CDW57009.1 - 8.2e-06 24.8 0.0 1.1e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 CDW57009.1 - 0.00035 20.4 0.0 0.00068 19.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.6 CDW57009.1 - 0.023 13.6 0.0 0.05 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 DUF3638 PF12340.8 CDW57009.1 - 0.036 13.4 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) AAA_22 PF13401.6 CDW57009.1 - 0.062 13.6 1.6 0.45 10.8 0.1 3.0 2 1 1 3 3 3 0 AAA domain DUF4203 PF13886.6 CDW57010.1 - 2.3e-22 79.7 15.2 2.9e-22 79.3 15.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Leader_Thr PF08254.11 CDW57010.1 - 3.1 7.6 7.5 7.6 6.4 7.5 1.6 1 0 0 1 1 1 0 Threonine leader peptide Ras PF00071.22 CDW57011.1 - 1.9e-66 222.7 0.4 2.3e-66 222.4 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW57011.1 - 3.5e-36 124.1 0.1 6.4e-36 123.2 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW57011.1 - 3.6e-16 59.1 0.1 4.4e-16 58.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW57011.1 - 1.9e-06 27.4 0.2 2.2e-06 27.2 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CDW57011.1 - 1.2e-05 25.0 0.3 0.00013 21.6 0.3 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CDW57011.1 - 4e-05 23.1 0.3 5.4e-05 22.7 0.3 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CDW57011.1 - 0.0004 20.3 0.4 0.95 9.3 0.1 2.3 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDW57011.1 - 0.00043 20.4 0.0 0.00066 19.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 CDW57011.1 - 0.0069 15.7 0.6 0.096 12.0 0.0 2.3 2 1 0 2 2 2 1 Septin PduV-EutP PF10662.9 CDW57011.1 - 0.034 13.9 0.0 0.41 10.4 0.0 2.4 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation DUF3963 PF13124.6 CDW57011.1 - 0.04 13.9 0.3 0.082 12.9 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) AAA PF00004.29 CDW57011.1 - 0.05 14.0 0.1 0.13 12.7 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW57011.1 - 0.063 13.7 0.0 0.093 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CDW57011.1 - 0.099 12.1 0.0 0.18 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region BORCS8 PF10167.9 CDW57011.1 - 0.11 12.4 1.0 0.27 11.2 0.7 1.6 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 8 7tm_1 PF00001.21 CDW57012.1 - 2e-37 128.9 19.6 2.7e-37 128.5 19.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Nup88 PF10168.9 CDW57013.1 - 4.7e-35 120.6 0.0 7e-35 120.0 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore component SIX1_SD PF16878.5 CDW57014.1 - 9.2e-37 126.0 1.5 1.1e-35 122.4 0.1 2.1 2 0 0 2 2 2 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 CDW57014.1 - 2.5e-13 49.7 1.0 2.5e-13 49.7 1.0 2.2 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 CDW57014.1 - 8.8e-09 35.1 0.1 2.3e-08 33.8 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Terminase_5 PF06056.12 CDW57014.1 - 0.067 13.1 0.1 0.54 10.2 0.0 2.3 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Exo_endo_phos PF03372.23 CDW57015.1 - 4.9e-18 65.5 0.0 6.6e-18 65.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 CDW57015.1 - 0.093 12.6 0.0 0.8 9.6 0.0 2.2 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase PAS_11 PF14598.6 CDW57016.1 - 2.3e-14 53.5 0.0 7.9e-11 42.1 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 CDW57016.1 - 3e-13 49.8 0.0 7.8e-08 32.5 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 CDW57016.1 - 4.1e-07 30.0 0.0 8.1e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 PAS fold HLH PF00010.26 CDW57016.1 - 0.00015 21.7 0.1 0.00029 20.7 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_9 PF13426.7 CDW57016.1 - 0.0007 19.8 0.0 0.0018 18.5 0.0 1.6 2 0 0 2 2 2 1 PAS domain PAS_2 PF08446.11 CDW57016.1 - 0.03 15.0 0.0 0.093 13.4 0.0 1.8 1 0 0 1 1 1 0 PAS fold Translin PF01997.16 CDW57017.1 - 1.2e-13 51.6 0.0 3.2e-13 50.1 0.0 1.6 1 1 0 1 1 1 1 Translin family Carb_anhydrase PF00194.21 CDW57018.1 - 5.5e-72 242.4 0.0 3.3e-71 239.8 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase LapA_dom PF06305.11 CDW57019.1 - 0.014 15.2 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF5436 PF17504.2 CDW57019.1 - 0.029 14.7 0.3 0.036 14.4 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5436) MscL PF01741.18 CDW57019.1 - 0.048 14.0 0.1 0.049 13.9 0.1 1.1 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL TMEM154 PF15102.6 CDW57019.1 - 0.054 13.4 0.6 0.065 13.1 0.6 1.1 1 0 0 1 1 1 0 TMEM154 protein family MitoNEET_N PF10660.9 CDW57019.1 - 0.1 12.7 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus ASFV_J13L PF05568.11 CDW57019.1 - 0.2 11.4 0.1 0.2 11.4 0.1 1.0 1 0 0 1 1 1 0 African swine fever virus J13L protein EF-hand_7 PF13499.6 CDW57021.1 - 6.9e-15 55.3 4.7 3.6e-07 30.5 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW57021.1 - 1.6e-12 46.3 8.8 2.5e-07 30.1 1.4 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 CDW57021.1 - 2.1e-12 45.6 15.1 2.8e-07 29.6 2.4 4.5 5 0 0 5 5 5 2 EF hand EF-hand_5 PF13202.6 CDW57021.1 - 8.7e-08 31.3 6.0 3.2e-05 23.2 2.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDW57021.1 - 1.1e-05 25.2 10.8 0.017 15.0 0.8 4.2 2 1 1 3 3 3 3 EF-hand domain pair SurA_N_2 PF13623.6 CDW57021.1 - 0.00023 21.0 0.1 0.68 9.8 0.0 2.2 2 0 0 2 2 2 2 SurA N-terminal domain EF-hand_11 PF08976.11 CDW57021.1 - 0.00038 21.3 0.2 0.014 16.3 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain AF0941-like PF14591.6 CDW57021.1 - 0.0032 18.0 0.7 0.038 14.5 0.2 2.1 2 0 0 2 2 2 1 AF0941-like SurA_N_3 PF13624.6 CDW57021.1 - 0.03 14.1 0.0 1 9.1 0.0 2.0 2 0 0 2 2 2 0 SurA N-terminal domain UPF0154 PF03672.13 CDW57021.1 - 0.059 13.4 0.0 0.72 9.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF3741 PF12552.8 CDW57021.1 - 0.1 12.5 1.1 0.29 11.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) LRR_4 PF12799.7 CDW57022.1 - 7.4e-05 23.0 0.1 0.02 15.3 0.0 2.8 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDW57022.1 - 0.00096 19.4 2.5 27 5.8 0.0 4.9 2 2 2 4 4 4 1 Leucine Rich Repeat LRR_8 PF13855.6 CDW57022.1 - 0.0012 18.5 0.1 0.0076 16.0 0.0 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 CDW57022.1 - 0.022 14.8 0.2 25 5.2 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Motile_Sperm PF00635.26 CDW57023.1 - 1.1e-08 34.9 0.0 1.8e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain RrnaAD PF00398.20 CDW57024.1 - 0.088 11.9 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase LPG_synthase_TM PF03706.13 CDW57024.1 - 0.27 10.7 0.1 0.37 10.3 0.1 1.1 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Rcd1 PF04078.13 CDW57025.1 - 3.6e-88 295.2 0.0 4.1e-88 295.0 0.0 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DB PF01682.19 CDW57026.1 - 3.4e-13 49.7 8.2 3.4e-13 49.7 8.2 2.2 1 1 0 2 2 2 2 DB module Dynein_C PF18199.1 CDW57027.1 - 2.8e-45 154.9 0.1 4e-45 154.4 0.1 1.2 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 CDW57027.1 - 3.8e-35 121.1 0.0 6.5e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 CDW57027.1 - 2.3e-28 98.7 0.0 1.4e-27 96.1 0.0 2.3 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain Collagen PF01391.18 CDW57028.1 - 9.2e-18 63.8 75.4 1.3e-06 28.1 33.4 3.7 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW57028.1 - 4.4e-13 49.1 0.8 6.6e-13 48.5 0.8 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain 4HB_MCP_1 PF12729.7 CDW57029.1 - 0.027 14.0 1.0 0.12 11.9 0.2 2.2 2 1 0 2 2 2 0 Four helix bundle sensory module for signal transduction BBS2_Mid PF14783.6 CDW57029.1 - 0.074 13.1 0.0 0.22 11.5 0.0 1.9 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region LXG PF04740.12 CDW57029.1 - 0.13 11.9 0.2 0.23 11.1 0.2 1.3 1 0 0 1 1 1 0 LXG domain of WXG superfamily Helicase_PWI PF18149.1 CDW57030.1 - 0.15 12.2 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 N-terminal helicase PWI domain PLDc_3 PF13918.6 CDW57032.1 - 2.7e-38 131.4 0.0 4.2e-38 130.7 0.0 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 CDW57032.1 - 1.3e-20 73.6 0.2 5.9e-10 39.1 0.1 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CDW57032.1 - 1.6e-11 43.9 8.6 3.8e-09 36.3 0.7 2.8 3 0 0 3 3 3 2 Phospholipase D Active site motif Sec7_N PF12783.7 CDW57033.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal PC4 PF02229.16 CDW57036.1 - 7.6e-23 79.9 0.1 1.1e-22 79.4 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) CBM_14 PF01607.24 CDW57037.1 - 2e-07 31.1 3.6 0.00021 21.4 0.6 3.5 4 0 0 4 4 4 2 Chitin binding Peritrophin-A domain DUF5401 PF17380.2 CDW57037.1 - 0.0055 14.8 1.8 0.097 10.7 0.5 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF5401) ERK-JNK_inhib PF15002.6 CDW57038.1 - 1.1e-42 145.9 0.0 1.5e-42 145.6 0.0 1.0 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor Rotavirus_VP1 PF12289.8 CDW57038.1 - 0.2 10.7 0.0 0.27 10.3 0.0 1.1 1 0 0 1 1 1 0 Rotavirus VP1 C-terminal domain Tim54 PF11711.8 CDW57039.1 - 0.00069 18.5 0.4 0.0084 14.9 0.0 2.0 2 0 0 2 2 2 2 Inner membrane protein import complex subunit Tim54 DnaJ PF00226.31 CDW57040.1 - 5.3e-28 96.9 4.9 8.6e-28 96.3 4.9 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 CDW57040.1 - 1.1e-23 83.9 0.1 1.8e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 CDW57040.1 - 3.3e-10 40.2 13.1 6.3e-10 39.3 13.1 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CDW57040.1 - 0.073 13.1 18.7 3 7.9 2.8 4.3 2 1 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-TFIIB PF13453.6 CDW57040.1 - 0.55 9.6 3.6 13 5.2 0.0 2.7 2 0 0 2 2 2 0 Transcription factor zinc-finger HypA PF01155.19 CDW57040.1 - 2.2 8.3 7.5 0.69 9.9 0.3 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF5351 PF17302.2 CDW57040.1 - 3.5 7.9 21.2 5.7 7.2 1.0 4.6 4 0 0 4 4 4 0 Family of unknown function (DUF5351) FGGY_N PF00370.21 CDW57041.1 - 2.6e-65 220.4 0.0 4.4e-65 219.7 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CDW57041.1 - 7.5e-52 175.9 0.1 1.2e-51 175.3 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Ku_PK_bind PF08785.11 CDW57041.1 - 0.21 11.8 0.5 0.44 10.7 0.5 1.5 1 0 0 1 1 1 0 Ku C terminal domain like CCDC73 PF15818.5 CDW57041.1 - 0.65 7.8 2.2 0.95 7.2 2.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 73 family DNase_II PF03265.15 CDW57042.1 - 9.8e-40 136.8 0.0 1.2e-39 136.5 0.0 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II MOZ_SAS PF01853.18 CDW57043.1 - 4.1e-17 62.4 0.3 9.5e-17 61.2 0.3 1.6 1 1 0 1 1 1 1 MOZ/SAS family Prp19 PF08606.11 CDW57044.1 - 2.6e-27 94.6 1.2 4.7e-27 93.8 1.2 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 CDW57044.1 - 6.5e-26 90.1 6.9 2.5e-06 28.1 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57044.1 - 3e-08 33.9 0.4 0.15 12.4 0.0 4.3 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW57044.1 - 0.0008 19.3 0.3 0.92 9.4 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 CDW57044.1 - 0.0086 14.6 0.1 0.081 11.4 0.0 2.2 2 0 0 2 2 2 1 Cytochrome D1 heme domain DDRGK PF09756.9 CDW57045.1 - 3.5e-53 180.0 19.8 4.1e-53 179.8 19.8 1.0 1 0 0 1 1 1 1 DDRGK domain FeoC PF09012.10 CDW57045.1 - 0.0012 18.9 0.5 2.4 8.3 0.0 2.8 3 0 0 3 3 3 2 FeoC like transcriptional regulator RII_binding_1 PF10522.9 CDW57045.1 - 0.03 14.5 0.1 0.14 12.4 0.1 2.2 2 0 0 2 2 2 0 RII binding domain DUF4065 PF13274.6 CDW57045.1 - 0.61 11.0 6.7 5.6 7.9 6.7 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) DUF4661 PF15576.6 CDW57045.1 - 0.88 9.4 3.9 1.1 9.1 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) RR_TM4-6 PF06459.12 CDW57045.1 - 0.92 9.3 15.1 1.2 8.8 15.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF3_subunit PF08597.10 CDW57045.1 - 4 7.3 23.7 5.5 6.8 23.7 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit AAA_11 PF13086.6 CDW57045.1 - 4.1 7.1 10.3 5.7 6.6 10.3 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 CDW57045.1 - 4.3 6.0 7.8 4.9 5.8 7.8 1.1 1 0 0 1 1 1 0 Presenilin HLH PF00010.26 CDW57046.1 - 0.00015 21.7 0.1 0.00015 21.7 0.1 1.6 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain FhuF PF06276.12 CDW57046.1 - 0.0034 17.8 0.0 0.0038 17.7 0.0 1.1 1 0 0 1 1 1 1 Ferric iron reductase FhuF-like transporter HLH PF00010.26 CDW57048.1 - 0.0018 18.2 0.1 0.0028 17.6 0.1 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Glutaredoxin2_C PF04399.13 CDW57048.1 - 0.019 14.8 0.0 0.024 14.5 0.0 1.1 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain YgaB PF14182.6 CDW57048.1 - 0.081 13.3 1.0 0.11 12.9 1.0 1.2 1 0 0 1 1 1 0 YgaB-like protein Cyclin_N PF00134.23 CDW57049.1 - 2.5e-07 30.5 0.0 5e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CDW57049.1 - 0.0033 17.8 0.0 0.0044 17.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin Xlink PF00193.17 CDW57049.1 - 0.09 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Extracellular link domain Putative_PNPOx PF01243.20 CDW57050.1 - 1.5e-24 86.0 0.0 2.1e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 CDW57050.1 - 1.5e-19 69.8 1.3 2.7e-19 69.0 1.3 1.4 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyrid_ox_like PF16242.5 CDW57050.1 - 7.2e-07 28.9 0.0 2.3e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase like Pyridox_oxase_2 PF12766.7 CDW57050.1 - 1e-05 26.1 0.0 1.8e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase SNF2_N PF00176.23 CDW57051.1 - 1.2e-31 109.8 0.1 2.6e-31 108.6 0.0 1.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW57051.1 - 5.7e-14 52.4 0.2 1.6e-13 51.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW57051.1 - 1.2e-07 31.9 0.0 1e-06 28.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDW57051.1 - 1.1e-05 25.3 0.0 0.00011 22.0 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase TniB PF05621.11 CDW57051.1 - 0.025 14.0 0.1 0.11 11.9 0.1 2.1 2 0 0 2 2 2 0 Bacterial TniB protein DEAD_2 PF06733.15 CDW57051.1 - 0.028 14.1 0.2 0.058 13.0 0.2 1.5 1 0 0 1 1 1 0 DEAD_2 ERCC3_RAD25_C PF16203.5 CDW57051.1 - 0.086 12.0 0.1 0.19 10.9 0.1 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 CDW57051.1 - 0.099 12.7 0.1 0.53 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain HARP PF07443.13 CDW57051.1 - 0.13 11.9 0.3 0.47 10.1 0.0 2.1 2 0 0 2 2 2 0 HepA-related protein (HARP) 7tm_1 PF00001.21 CDW57052.1 - 2.9e-50 171.1 17.6 2.9e-50 171.1 17.6 1.5 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 CDW57052.1 - 1.2e-07 31.4 18.3 1.2e-07 31.4 18.3 1.6 1 1 1 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 CDW57052.1 - 6.3e-07 29.4 12.8 1.8e-06 27.9 12.8 1.8 1 1 0 1 1 1 1 Olfactory receptor CPG4 PF15481.6 CDW57053.1 - 1.7e-06 28.5 2.5 3.4e-06 27.6 1.3 2.0 2 1 0 2 2 2 1 Chondroitin proteoglycan 4 DUF19 PF01579.18 CDW57053.1 - 9.2e-05 22.3 5.0 0.001 18.9 5.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF19) Peptidase_M14 PF00246.24 CDW57054.1 - 2.7e-53 181.6 0.0 6.2e-50 170.6 0.0 2.1 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 CDW57054.1 - 9.7e-07 28.1 0.0 1.4e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family CarbopepD_reg_2 PF13715.6 CDW57054.1 - 0.034 14.1 0.0 0.062 13.3 0.0 1.5 1 0 0 1 1 1 0 CarboxypepD_reg-like domain NNMT_PNMT_TEMT PF01234.17 CDW57055.1 - 1.1e-59 201.8 0.0 1.2e-59 201.6 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_25 PF13649.6 CDW57055.1 - 0.0067 17.1 0.0 0.21 12.3 0.0 2.5 2 1 1 3 3 3 1 Methyltransferase domain NodS PF05401.11 CDW57055.1 - 0.012 15.2 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Pox_MCEL PF03291.16 CDW57055.1 - 0.015 14.4 0.0 0.033 13.3 0.0 1.5 2 0 0 2 2 2 0 mRNA capping enzyme Methyltransf_11 PF08241.12 CDW57055.1 - 0.017 15.8 0.0 0.12 13.0 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain AKAP7_NLS PF10469.9 CDW57057.1 - 1.7e-38 132.6 0.0 2.3e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.29 CDW57057.1 - 3.9e-08 33.0 0.0 7.8e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 KH domain 2_5_RNA_ligase2 PF13563.6 CDW57057.1 - 0.0032 17.4 0.0 0.007 16.3 0.0 1.5 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily SWIRM PF04433.17 CDW57058.1 - 1.7e-31 108.4 0.6 5.6e-31 106.7 0.2 2.2 3 0 0 3 3 3 1 SWIRM domain SWIRM-assoc_1 PF16495.5 CDW57058.1 - 4.5e-27 93.8 9.7 4.5e-27 93.8 9.7 1.7 2 0 0 2 2 2 1 SWIRM-associated region 1 SWIRM-assoc_3 PF16498.5 CDW57058.1 - 4.3e-22 78.1 0.1 4.3e-22 78.1 0.1 2.3 2 1 0 2 2 2 1 SWIRM-associated domain at the C-terminal Myb_DNA-binding PF00249.31 CDW57058.1 - 3e-08 33.7 0.2 6.1e-08 32.7 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDW57058.1 - 4.9e-05 23.5 0.0 0.00013 22.2 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain RNA_pol_Rpb4 PF03874.16 CDW57060.1 - 1.2e-16 61.1 1.8 1.6e-16 60.7 1.8 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 DUF2757 PF10955.8 CDW57060.1 - 0.028 14.7 0.2 0.052 13.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2757) Ion_trans_2 PF07885.16 CDW57061.1 - 6.6e-33 112.5 13.4 2.2e-16 59.6 4.3 2.5 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 CDW57061.1 - 0.00037 19.8 7.3 0.032 13.4 0.0 2.2 2 0 0 2 2 2 2 Ion transport protein Ig_3 PF13927.6 CDW57062.1 - 9.7e-130 423.4 7.9 4.2e-12 46.5 1.3 13.8 13 0 0 13 13 13 13 Immunoglobulin domain I-set PF07679.16 CDW57062.1 - 4.6e-123 401.6 0.0 1.5e-12 47.4 0.0 14.1 14 0 0 14 14 14 13 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW57062.1 - 2.9e-93 306.3 1.5 3.3e-10 40.1 0.0 14.4 14 1 1 15 15 13 12 Immunoglobulin domain ig PF00047.25 CDW57062.1 - 8.5e-86 282.3 0.0 1.6e-09 37.8 0.0 14.3 13 0 0 13 13 13 13 Immunoglobulin domain Laminin_G_2 PF02210.24 CDW57062.1 - 3e-64 215.3 2.6 1.8e-26 93.2 0.0 3.6 3 0 0 3 3 3 3 Laminin G domain Laminin_B PF00052.18 CDW57062.1 - 8e-63 210.3 0.0 1.1e-33 116.0 0.0 2.5 2 0 0 2 2 2 2 Laminin B (Domain IV) Laminin_G_1 PF00054.23 CDW57062.1 - 2.7e-58 195.8 0.0 2.1e-24 86.2 0.0 3.6 3 0 0 3 3 3 3 Laminin G domain V-set PF07686.17 CDW57062.1 - 4.5e-51 171.6 23.7 0.00021 21.4 0.0 21.5 13 10 4 18 18 18 12 Immunoglobulin V-set domain Ldl_recept_a PF00057.18 CDW57062.1 - 1.4e-28 98.8 51.5 2.9e-13 49.8 15.4 5.9 7 0 0 7 7 3 3 Low-density lipoprotein receptor domain class A Ig_6 PF18452.1 CDW57062.1 - 5e-19 67.6 0.0 0.72 9.5 0.0 11.8 13 0 0 13 13 12 3 Immunoglobulin domain Ig_4 PF16680.5 CDW57062.1 - 2.8e-16 59.5 1.0 0.14 12.4 0.0 12.0 13 0 0 13 13 13 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 CDW57062.1 - 7.6e-14 51.6 11.4 0.0066 16.5 0.1 7.5 7 0 0 7 7 7 3 CD80-like C2-set immunoglobulin domain Laminin_EGF PF00053.24 CDW57062.1 - 3.1e-12 46.5 74.7 1.8e-06 28.0 15.8 12.1 10 3 0 11 11 9 5 Laminin EGF domain Izumo-Ig PF16706.5 CDW57062.1 - 6.5e-09 35.7 4.1 8.8 6.5 0.0 9.6 11 0 0 11 11 11 1 Izumo-like Immunoglobulin domain Laminin_G_3 PF13385.6 CDW57062.1 - 9e-07 29.2 0.1 0.022 14.9 0.0 3.2 3 0 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily Herpes_gE PF02480.16 CDW57062.1 - 1.3e-05 24.1 0.0 0.53 9.0 0.0 5.8 6 2 1 7 7 7 1 Alphaherpesvirus glycoprotein E C2-set PF05790.15 CDW57062.1 - 0.00052 20.1 0.0 43 4.4 0.0 6.8 7 0 0 7 7 7 0 Immunoglobulin C2-set domain Lep_receptor_Ig PF06328.11 CDW57062.1 - 0.00063 19.7 0.1 16 5.5 0.0 5.3 6 0 0 6 6 6 0 Ig-like C2-type domain SLAM PF06214.11 CDW57062.1 - 0.16 11.9 0.0 0.55 10.2 0.0 1.8 2 0 0 2 2 1 0 Signaling lymphocytic activation molecule (SLAM) protein LMBR1 PF04791.16 CDW57063.1 - 1.5e-146 489.3 19.4 2e-146 488.9 19.4 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein TarH PF02203.15 CDW57064.1 - 0.024 14.6 0.2 0.063 13.2 0.2 1.7 1 0 0 1 1 1 0 Tar ligand binding domain homologue HORMA PF02301.18 CDW57065.1 - 0.00058 19.5 0.1 0.082 12.5 0.0 2.1 1 1 1 2 2 2 2 HORMA domain NdhS PF11623.8 CDW57065.1 - 0.11 12.1 0.1 0.25 11.0 0.1 1.6 1 0 0 1 1 1 0 NAD(P)H dehydrogenase subunit S GCS PF03074.16 CDW57067.1 - 1.9e-163 544.1 0.0 2.3e-163 543.8 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 CDW57067.1 - 0.015 14.6 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Glutamate-cysteine ligase family 2(GCS2) Nuc_rec_co-act PF08815.10 CDW57067.1 - 0.11 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear receptor coactivator Forkhead PF00250.18 CDW57068.1 - 3.6e-39 132.9 0.0 5.7e-39 132.3 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain TMEM52 PF14979.6 CDW57071.1 - 0.018 14.9 5.4 0.089 12.7 5.4 2.3 1 1 0 1 1 1 0 Transmembrane 52 DUF3290 PF11694.8 CDW57071.1 - 0.083 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) Cadherin_C_2 PF16492.5 CDW57071.1 - 2.2 9.1 5.9 14 6.5 5.9 2.4 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal AXIN1_TNKS_BD PF16646.5 CDW57071.1 - 3.2 8.7 12.2 0.1 13.5 3.8 2.4 2 1 1 3 3 3 0 Axin-1 tankyrase binding domain ADP_PFK_GK PF04587.15 CDW57072.1 - 6.8e-111 370.8 0.0 8.5e-111 370.5 0.0 1.1 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region GRASP55_65 PF04495.14 CDW57073.1 - 1.8e-71 238.8 0.1 4.3e-50 169.6 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 CDW57073.1 - 4.6e-10 39.2 0.1 0.0016 18.2 0.0 2.8 2 1 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 CDW57073.1 - 2.7e-07 30.8 0.0 0.001 19.4 0.0 2.4 2 0 0 2 2 2 2 PDZ domain WD40 PF00400.32 CDW57074.1 - 1.3e-26 92.3 11.7 1.4e-05 25.8 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57074.1 - 3.1e-10 40.2 0.1 0.0019 18.5 0.0 4.5 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 CDW57074.1 - 8.1e-09 35.0 0.0 1.6e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain Ge1_WD40 PF16529.5 CDW57074.1 - 0.00055 19.0 0.0 0.25 10.3 0.0 2.6 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CDW57074.1 - 0.021 13.5 0.0 28 3.2 0.0 3.4 2 1 1 3 3 3 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 CDW57074.1 - 0.1 13.1 1.1 1.2 9.7 0.0 2.8 3 0 0 3 3 3 0 PQQ-like domain WD40_like PF17005.5 CDW57074.1 - 0.13 11.6 0.3 1.3 8.3 0.0 2.6 2 1 0 3 3 3 0 WD40-like domain Zona_pellucida PF00100.23 CDW57075.1 - 4.6e-09 36.5 3.1 6.6e-09 36.0 3.1 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain TMEM51 PF15345.6 CDW57076.1 - 0.057 13.2 0.0 0.084 12.7 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 BTB_3 PF16017.5 CDW57077.1 - 5.3e-46 155.1 0.0 8.2e-46 154.5 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 CDW57077.1 - 5.9e-05 23.3 0.0 0.00012 22.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain ALG3 PF05208.13 CDW57078.1 - 7.7e-132 440.1 22.2 1e-131 439.7 22.2 1.0 1 0 0 1 1 1 1 ALG3 protein CLP_protease PF00574.23 CDW57079.1 - 4.3e-76 254.9 0.0 5.1e-76 254.6 0.0 1.0 1 0 0 1 1 1 1 Clp protease Peptidase_M15_3 PF08291.11 CDW57079.1 - 0.14 12.3 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase M15 SBF PF01758.16 CDW57080.1 - 3.5e-13 49.7 11.6 3.5e-13 49.7 11.6 2.2 2 1 1 3 3 3 1 Sodium Bile acid symporter family SLM4 PF16818.5 CDW57080.1 - 0.054 13.5 0.1 0.09 12.7 0.1 1.2 1 0 0 1 1 1 0 Protein SLM4 Elf1 PF05129.13 CDW57081.1 - 1.3e-30 105.2 1.4 1.5e-30 105.1 1.4 1.0 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 CDW57081.1 - 0.0037 17.6 0.8 0.0045 17.3 0.8 1.2 1 0 0 1 1 1 1 Restriction alleviation protein Lar GWT1 PF06423.12 CDW57082.1 - 7.6e-23 81.3 5.0 1.9e-22 80.0 5.0 1.7 1 0 0 1 1 1 1 GWT1 DUF373 PF04123.13 CDW57082.1 - 0.69 9.3 6.6 0.3 10.5 2.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF373) DUF2070 PF09843.9 CDW57082.1 - 2.1 6.5 9.7 0.34 9.2 5.9 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) HA2 PF04408.23 CDW57083.1 - 1.5e-16 60.6 0.0 1.5e-16 60.6 0.0 2.1 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CDW57083.1 - 4e-13 49.5 0.0 8.6e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CDW57083.1 - 3.3e-10 40.3 0.0 7.3e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW57083.1 - 1e-06 28.7 0.0 2.3e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CDW57083.1 - 0.0011 19.2 0.0 0.0034 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 CDW57083.1 - 0.0063 16.0 0.0 0.47 9.9 0.0 2.7 2 0 0 2 2 2 1 PhoH-like protein ABC_tran PF00005.27 CDW57083.1 - 0.017 15.7 0.0 0.37 11.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_25 PF13481.6 CDW57083.1 - 0.04 13.5 0.0 0.093 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDW57083.1 - 0.065 13.0 0.0 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 CDW57083.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region dsrm PF00035.26 CDW57084.1 - 7e-25 87.5 0.0 3.7e-07 30.7 0.0 3.2 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CDW57084.1 - 2.8e-15 56.3 2.3 5.3e-05 23.4 0.1 4.9 3 2 0 3 3 3 3 double strand RNA binding domain from DEAD END PROTEIN 1 Homeodomain PF00046.29 CDW57085.1 - 1.1e-22 79.6 3.5 2.8e-22 78.3 2.9 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW57085.1 - 0.016 15.1 2.2 0.037 13.9 1.5 2.1 2 1 0 2 2 2 0 Homeobox KN domain Homez PF11569.8 CDW57085.1 - 0.057 12.9 0.0 0.089 12.3 0.0 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez 7tm_3 PF00003.22 CDW57087.1 - 9.5e-15 55.0 17.3 1.4e-14 54.4 17.3 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF1003 PF06210.11 CDW57087.1 - 0.31 11.1 1.5 4.5 7.4 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1003) Pkinase_Tyr PF07714.17 CDW57088.1 - 1.8e-36 125.7 0.0 8.4e-36 123.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW57088.1 - 5.1e-25 88.3 0.0 3.5e-24 85.6 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain C1_1 PF00130.22 CDW57088.1 - 1.9e-07 30.8 4.5 4.6e-07 29.6 4.5 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CDW57088.1 - 0.031 14.6 6.6 0.063 13.6 6.6 1.5 1 0 0 1 1 1 0 C1 domain zf-RING-like PF08746.11 CDW57088.1 - 0.86 10.0 7.8 2.4 8.5 7.8 1.8 1 0 0 1 1 1 0 RING-like domain LIM PF00412.22 CDW57089.1 - 6.1e-13 48.8 4.4 7.8e-13 48.5 4.4 1.2 1 0 0 1 1 1 1 LIM domain zf-SNAP50_C PF12251.8 CDW57089.1 - 0.04 13.6 0.4 0.041 13.6 0.4 1.2 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal zf-DNA_Pol PF08996.10 CDW57089.1 - 0.53 10.0 2.4 0.56 9.9 2.4 1.1 1 0 0 1 1 1 0 DNA Polymerase alpha zinc finger zf-C3HC4_3 PF13920.6 CDW57089.1 - 4.5 7.2 11.5 13 5.8 0.3 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Sec23_trunk PF04811.15 CDW57090.1 - 5.6e-45 153.8 0.0 8.2e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CDW57090.1 - 9.1e-17 61.6 0.0 1.8e-16 60.6 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CDW57090.1 - 4e-15 55.6 4.3 8.4e-15 54.5 4.3 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 CDW57090.1 - 6.8e-15 54.8 0.0 1.5e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain OLF PF02191.16 CDW57092.1 - 1.7e-56 191.5 1.6 4.2e-56 190.3 1.6 1.6 1 1 0 1 1 1 1 Olfactomedin-like domain Collagen PF01391.18 CDW57092.1 - 1.3e-08 34.4 8.6 2.3e-08 33.6 8.6 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) RNA_pol_Rpc4 PF05132.14 CDW57093.1 - 1.5e-09 38.5 0.0 3.5e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase III RPC4 UPF0020 PF01170.18 CDW57094.1 - 2.2e-06 27.5 0.0 4.2e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 CDW57094.1 - 0.021 14.5 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 DNA methylase N6_Mtase PF02384.16 CDW57094.1 - 0.11 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase AA_permease_2 PF13520.6 CDW57095.1 - 1.3e-55 188.9 44.5 1.6e-55 188.6 44.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW57095.1 - 3.5e-24 85.3 40.3 5.8e-24 84.5 40.3 1.3 1 1 0 1 1 1 1 Amino acid permease Med24_N PF11277.8 CDW57096.1 - 1.9e-40 138.9 0.0 3e-36 124.9 0.0 2.1 2 0 0 2 2 2 2 Mediator complex subunit 24 N-terminal Phage_int_SAM_6 PF18644.1 CDW57096.1 - 0.1 12.7 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Phage integrase SAM-like domain Peptidase_M14 PF00246.24 CDW57097.1 - 3.1e-81 273.4 0.1 3.9e-81 273.0 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 CDW57097.1 - 8.9e-07 29.2 0.1 2.2e-06 28.0 0.1 1.6 1 0 0 1 1 1 1 Carboxypeptidase activation peptide C2 PF00168.30 CDW57098.1 - 9.2e-22 77.3 0.6 1.2e-12 48.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain TonB_2 PF13103.6 CDW57098.1 - 0.013 15.7 0.1 0.14 12.4 0.0 2.3 2 0 0 2 2 2 0 TonB C terminal 6PGD PF00393.19 CDW57100.1 - 5.8e-124 413.2 0.1 7.1e-124 412.9 0.1 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CDW57100.1 - 5.1e-50 169.7 0.0 8.8e-50 169.0 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DnaG_DnaB_bind PF08278.11 CDW57100.1 - 0.013 16.1 0.0 0.036 14.7 0.0 1.7 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding IlvN PF07991.12 CDW57100.1 - 0.014 15.0 0.7 0.31 10.6 0.0 2.9 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 CDW57100.1 - 0.041 13.3 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CDW57100.1 - 0.088 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CDW57100.1 - 0.14 12.8 0.1 0.33 11.6 0.1 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NuA4 PF09340.10 CDW57101.1 - 0.00016 21.5 1.0 0.00038 20.3 1.0 1.6 1 1 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Vps55 PF04133.14 CDW57102.1 - 1.9e-38 131.0 4.0 2.1e-38 130.8 4.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4231 PF14015.6 CDW57102.1 - 0.083 13.4 2.2 0.1 13.1 0.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DUF4620 PF15399.6 CDW57102.1 - 0.16 12.3 0.3 0.23 11.8 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4620) YibE_F PF07907.11 CDW57102.1 - 0.45 10.0 6.2 0.23 10.9 3.8 1.6 1 1 0 1 1 1 0 YibE/F-like protein Peptidase_U4 PF03419.13 CDW57102.1 - 1.3 8.3 3.8 1.5 8.0 3.8 1.0 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Ima1_N PF09779.9 CDW57103.1 - 9.9e-29 100.9 8.8 1.8e-28 100.1 8.8 1.4 1 0 0 1 1 1 1 Ima1 N-terminal domain DUF2448 PF10476.9 CDW57103.1 - 0.092 12.6 2.7 0.18 11.7 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) zf-ACC PF17848.1 CDW57103.1 - 0.27 11.4 5.0 3.8 7.7 0.3 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Collagen PF01391.18 CDW57104.1 - 2.6e-26 91.1 110.4 1.8e-08 34.0 29.0 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW57104.1 - 1.3e-11 44.4 0.2 1.8e-11 43.9 0.2 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain MoCF_biosynth PF00994.24 CDW57105.1 - 3.9e-26 91.4 0.0 4.5e-26 91.2 0.0 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain I-set PF07679.16 CDW57106.1 - 2.4e-10 40.4 0.1 4.9e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW57106.1 - 2.6e-10 40.7 2.4 3.3e-06 27.6 0.2 2.9 2 1 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 CDW57106.1 - 1.6e-07 31.5 1.8 1.2e-05 25.5 0.1 2.8 2 1 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 CDW57106.1 - 1.7e-07 31.4 0.4 0.0034 17.5 0.0 2.9 2 1 0 2 2 2 2 Immunoglobulin V-set domain ig PF00047.25 CDW57106.1 - 2.6e-07 30.7 0.3 0.0029 17.8 0.0 2.5 2 0 0 2 2 2 2 Immunoglobulin domain Ig_6 PF18452.1 CDW57106.1 - 0.00011 21.7 0.1 0.048 13.2 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain Receptor_2B4 PF11465.8 CDW57106.1 - 0.2 11.9 0.8 11 6.2 0.1 2.9 2 2 0 2 2 2 0 Natural killer cell receptor 2B4 GST_C_3 PF14497.6 CDW57108.1 - 2.4e-32 111.1 0.1 1.5e-17 63.6 0.0 2.2 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CDW57108.1 - 4.3e-21 74.9 0.0 6.3e-11 42.3 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDW57108.1 - 2.6e-15 56.2 0.0 2.2e-06 27.6 0.0 2.8 2 1 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CDW57108.1 - 5.2e-15 55.5 0.0 6.1e-07 29.7 0.0 2.6 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 CDW57108.1 - 4.2e-09 36.1 0.0 0.0042 16.8 0.0 2.7 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CDW57108.1 - 1.5e-08 34.9 0.0 0.0022 18.3 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CDW57108.1 - 1.8e-06 28.1 0.0 0.074 13.4 0.0 2.7 2 1 0 2 2 2 2 Glutathione S-transferase, N-terminal domain Glyco_hydro_77 PF02446.17 CDW57108.1 - 0.00049 19.1 0.0 0.3 9.9 0.0 2.1 2 0 0 2 2 2 2 4-alpha-glucanotransferase DUF2095 PF09868.9 CDW57108.1 - 0.035 14.1 0.2 6 6.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) DNA_gyraseB_C PF00986.21 CDW57108.1 - 0.11 12.7 0.0 14 5.9 0.0 2.4 2 0 0 2 2 2 0 DNA gyrase B subunit, carboxyl terminus Glyco_hydro_4C PF11975.8 CDW57108.1 - 0.16 12.0 0.6 9.8 6.2 0.1 2.2 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase C-terminal domain HSP20 PF00011.21 CDW57110.1 - 7.8e-20 70.9 0.0 9.9e-20 70.6 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family BTB_2 PF02214.22 CDW57112.1 - 6.5e-26 90.5 0.2 1e-14 54.6 0.0 2.7 2 0 0 2 2 2 2 BTB/POZ domain HAP1_N PF04849.13 CDW57114.1 - 2.9e-22 79.3 4.5 3.5e-22 79.0 4.5 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DUF4618 PF15397.6 CDW57114.1 - 0.0066 15.9 4.0 0.009 15.5 4.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) Rootletin PF15035.6 CDW57114.1 - 0.0086 16.1 6.7 0.011 15.8 6.7 1.1 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion KxDL PF10241.9 CDW57114.1 - 0.019 15.2 3.1 0.032 14.5 3.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein DUF3557 PF12078.8 CDW57114.1 - 0.039 13.9 0.1 0.058 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) Zwint PF15556.6 CDW57114.1 - 0.046 13.2 4.3 0.061 12.8 4.3 1.2 1 0 0 1 1 1 0 ZW10 interactor YabA PF06156.13 CDW57114.1 - 0.054 14.1 1.9 0.08 13.6 1.9 1.4 1 0 0 1 1 1 0 Initiation control protein YabA Caudo_TAP PF02413.17 CDW57114.1 - 0.059 13.5 1.3 0.082 13.1 1.3 1.2 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Pox_T4_C PF04490.12 CDW57114.1 - 0.082 13.1 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus Pkinase PF00069.25 CDW57115.1 - 5.7e-66 222.6 0.0 1.3e-65 221.5 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57115.1 - 7.3e-27 94.3 0.0 3.1e-26 92.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW57115.1 - 1.8e-06 27.5 0.1 1.8e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW57115.1 - 3.7e-05 22.8 0.0 0.0005 19.1 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 CDW57115.1 - 0.0011 19.0 0.0 0.0024 17.8 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family LeuA_dimer PF08502.10 CDW57115.1 - 0.029 14.3 0.0 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 LeuA allosteric (dimerisation) domain Seadorna_VP7 PF07387.11 CDW57115.1 - 0.1 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 ADAM_CR_2 PF17771.1 CDW57118.1 - 5e-19 68.6 26.1 2.5e-17 63.1 5.4 3.7 2 1 0 2 2 2 2 ADAM cysteine-rich domain Reprolysin PF01421.19 CDW57118.1 - 4.1e-16 59.5 0.1 4.1e-16 59.5 0.1 1.8 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 CDW57118.1 - 4.3e-14 53.1 0.0 8.4e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 CDW57118.1 - 1.4e-07 31.6 0.8 5.6e-07 29.6 0.8 2.1 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CDW57118.1 - 1.2e-06 29.1 0.1 2.3e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 CDW57118.1 - 2.5e-05 24.0 0.1 5.4e-05 22.9 0.1 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 CDW57118.1 - 0.00012 22.3 0.0 0.00023 21.4 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Peptidase_M10 PF00413.24 CDW57118.1 - 0.0047 16.8 0.1 0.008 16.0 0.1 1.4 1 0 0 1 1 1 1 Matrixin Salp15 PF12115.8 CDW57118.1 - 0.0048 17.3 0.9 0.0048 17.3 0.9 3.3 3 0 0 3 3 3 1 Salivary protein of 15kDa inhibits CD4+ T cell activation Peptidase_M57 PF12388.8 CDW57118.1 - 0.0093 15.6 0.2 0.017 14.7 0.2 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 CDW57118.1 - 0.082 12.1 0.9 0.14 11.4 0.9 1.2 1 0 0 1 1 1 0 Met-zincin TSP_1 PF00090.19 CDW57118.1 - 6.1 7.1 11.3 41 4.5 6.3 3.2 2 0 0 2 2 2 0 Thrombospondin type 1 domain Solute_trans_a PF03619.16 CDW57120.1 - 5.6e-09 35.9 20.7 5.2e-08 32.7 20.7 2.0 1 1 0 1 1 1 1 Organic solute transporter Ostalpha DUF2615 PF11027.8 CDW57120.1 - 0.2 11.8 0.0 0.2 11.8 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2615) Dynamin_M PF01031.20 CDW57121.1 - 3.2e-105 351.4 0.9 3.2e-105 351.4 0.9 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 CDW57121.1 - 1.1e-53 181.8 0.0 2.5e-53 180.6 0.0 1.7 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 CDW57121.1 - 6e-29 100.0 1.4 1.8e-28 98.5 1.4 1.9 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.29 CDW57121.1 - 6.6e-09 36.2 0.2 1.7e-08 34.9 0.2 1.7 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.23 CDW57121.1 - 3.9e-05 23.7 0.0 0.00015 21.8 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase RasGAP PF00616.19 CDW57121.1 - 0.039 13.6 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase MMR_HSR1 PF01926.23 CDW57122.1 - 3e-11 43.4 0.0 5.9e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.6 CDW57122.1 - 6e-10 39.7 0.0 2.6e-09 37.6 0.0 2.1 2 1 0 2 2 2 1 GTP-binding GTPase N-terminal ATPase_2 PF01637.18 CDW57122.1 - 0.004 17.1 0.0 0.0069 16.3 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 CDW57122.1 - 0.007 16.8 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 CDW57122.1 - 0.024 14.1 0.0 0.043 13.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein GTP_EFTU PF00009.27 CDW57122.1 - 0.076 12.6 0.0 4.9 6.6 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_21 PF13304.6 CDW57122.1 - 0.093 12.5 0.0 21 4.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system FeoB_N PF02421.18 CDW57122.1 - 0.095 12.2 0.0 0.24 10.9 0.0 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B CLP1_P PF16575.5 CDW57122.1 - 0.097 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Caskin1-CID PF16600.5 CDW57122.1 - 0.14 12.8 0.0 0.29 11.7 0.0 1.4 1 0 0 1 1 1 0 Caskin1 CASK-interaction domain DNA_primase_lrg PF04104.14 CDW57123.1 - 4.8e-67 226.2 0.0 7.4e-67 225.5 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Pkinase_Tyr PF07714.17 CDW57124.1 - 1.4e-58 198.3 0.0 1.8e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW57124.1 - 6.1e-41 140.5 0.0 9e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW57124.1 - 1.5e-10 41.0 0.1 3.6e-10 39.8 0.1 1.7 1 0 0 1 1 1 1 SH2 domain APH PF01636.23 CDW57124.1 - 0.016 15.1 0.0 0.76 9.6 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CDW57124.1 - 0.037 13.0 0.0 0.051 12.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 CDW57124.1 - 0.063 12.0 0.1 0.095 11.5 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 CDW57124.1 - 0.064 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDW57124.1 - 0.065 12.5 0.1 0.35 10.1 0.1 2.0 1 1 0 1 1 1 0 Kinase-like CDC73_N PF16050.5 CDW57125.1 - 9.1e-55 186.0 0.8 1.4e-54 185.4 0.8 1.3 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal CDC73_C PF05179.14 CDW57125.1 - 8.3e-43 145.8 1.3 5.1e-26 91.2 0.2 2.9 2 1 1 3 3 3 2 RNA pol II accessory factor, Cdc73 family, C-terminal DUF21 PF01595.20 CDW57126.1 - 3.2e-37 127.9 0.2 5.3e-37 127.2 0.2 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CDW57126.1 - 1.9e-11 44.2 1.7 0.00034 21.0 0.3 3.5 3 0 0 3 3 3 2 CBS domain Kunitz_BPTI PF00014.23 CDW57127.1 - 2.7e-259 837.6 202.8 4.3e-20 71.7 5.6 14.1 14 0 0 14 14 14 14 Kunitz/Bovine pancreatic trypsin inhibitor domain SAD_SRA PF02182.17 CDW57127.1 - 1 9.1 25.3 39 3.9 0.1 9.3 9 3 2 11 11 11 0 SAD/SRA domain Cullin PF00888.22 CDW57127.1 - 2.7 6.5 4.0 52 2.2 0.0 4.5 7 0 0 7 7 7 0 Cullin family Kunitz_BPTI PF00014.23 CDW57128.1 - 1.2e-100 329.6 85.6 7.1e-20 71.0 8.2 6.0 6 0 0 6 6 6 6 Kunitz/Bovine pancreatic trypsin inhibitor domain SAD_SRA PF02182.17 CDW57128.1 - 0.002 17.9 0.7 0.33 10.6 0.0 3.9 5 1 0 5 5 5 1 SAD/SRA domain ATP-synt_C PF00137.21 CDW57129.1 - 4.8e-26 90.9 34.6 2.3e-13 50.3 14.4 2.3 2 0 0 2 2 2 2 ATP synthase subunit C SLATT_5 PF18160.1 CDW57129.1 - 0.051 12.9 0.2 0.41 10.0 0.0 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 CBF PF03914.17 CDW57130.1 - 1.9e-23 83.3 0.6 2.4e-23 83.0 0.6 1.1 1 0 0 1 1 1 1 CBF/Mak21 family CEBP_ZZ PF16366.5 CDW57131.1 - 1.1e-14 54.4 1.8 5.4e-14 52.2 2.2 1.9 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_7 PF16367.5 CDW57131.1 - 6.2e-06 26.2 0.1 5.3e-05 23.3 0.1 2.5 2 1 0 2 2 2 1 RNA recognition motif RRM_1 PF00076.22 CDW57131.1 - 0.0085 15.9 0.0 0.36 10.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-B_box PF00643.24 CDW57131.1 - 0.86 9.8 3.8 2.1 8.6 3.8 1.6 1 0 0 1 1 1 0 B-box zinc finger SPT16 PF08644.11 CDW57132.1 - 3.1e-24 85.9 9.6 3.2e-22 79.3 0.2 3.4 2 1 1 3 3 3 2 FACT complex subunit (SPT16/CDC68) Rtt106 PF08512.12 CDW57132.1 - 8.7e-17 61.3 0.0 2.1e-16 60.1 0.0 1.7 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Peptidase_M24 PF00557.24 CDW57132.1 - 2.1e-14 53.7 0.0 1.2e-13 51.3 0.0 1.9 1 1 0 2 2 2 1 Metallopeptidase family M24 FACT-Spt16_Nlob PF14826.6 CDW57132.1 - 7e-12 45.4 6.2 5.9e-05 22.9 0.0 4.0 4 0 0 4 4 4 3 FACT complex subunit SPT16 N-terminal lobe domain CAP PF00188.26 CDW57133.1 - 4.6e-08 34.0 1.5 9.3e-08 33.0 1.5 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family LicD PF04991.13 CDW57134.1 - 0.0011 19.1 0.0 0.029 14.5 0.1 2.2 2 0 0 2 2 2 2 LicD family WD40 PF00400.32 CDW57135.1 - 3.5e-37 125.7 17.5 1.1e-10 41.9 0.3 6.7 6 1 0 6 6 6 4 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 CDW57135.1 - 2.5e-16 60.1 0.0 4.5e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 CDW57135.1 - 5.6e-15 55.4 0.0 1.6e-07 31.5 0.0 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW57135.1 - 5.6e-05 22.0 0.2 0.0007 18.4 0.0 2.3 2 0 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 CDW57135.1 - 0.00016 21.1 0.0 0.69 9.2 0.0 3.1 3 1 1 4 4 4 2 WD40-like domain eIF2A PF08662.11 CDW57135.1 - 0.00028 20.8 0.0 0.00083 19.3 0.0 1.8 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A CX9C PF16860.5 CDW57135.1 - 0.019 15.0 0.3 0.053 13.6 0.3 1.8 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Ge1_WD40 PF16529.5 CDW57135.1 - 0.027 13.4 0.0 4.6 6.1 0.0 3.0 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 CDW57135.1 - 0.082 12.2 0.0 0.38 10.0 0.0 1.9 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DUF724 PF05266.14 CDW57136.1 - 0.0044 16.9 0.6 0.0044 16.9 0.6 6.7 4 1 3 8 8 8 1 Protein of unknown function (DUF724) gag_pre-integrs PF13976.6 CDW57136.1 - 0.036 13.9 0.3 0.13 12.2 0.3 2.0 1 0 0 1 1 1 0 GAG-pre-integrase domain CALCOCO1 PF07888.11 CDW57136.1 - 8.2 5.2 78.2 0.96 8.2 13.8 5.5 2 2 3 5 5 5 0 Calcium binding and coiled-coil domain (CALCOCO1) like Metallophos PF00149.28 CDW57137.1 - 1e-38 133.9 0.5 1.3e-38 133.5 0.5 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Chromo PF00385.24 CDW57138.1 - 0.0067 16.3 1.0 0.014 15.3 1.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain bZIP_C PF12498.8 CDW57138.1 - 0.096 13.7 0.0 0.16 12.9 0.0 1.3 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Chromo PF00385.24 CDW57139.1 - 3.2e-14 52.6 0.7 5.2e-14 51.9 0.7 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 CDW57139.1 - 4.8e-06 26.4 0.6 7.9e-06 25.7 0.6 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 CDW57139.1 - 0.00068 19.8 0.1 0.0016 18.6 0.1 1.6 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 CBX7_C PF17218.3 CDW57139.1 - 0.044 13.5 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 CBX family C-terminal motif BrkDBD PF09607.10 CDW57140.1 - 8.1e-10 38.3 0.3 1.2e-09 37.8 0.3 1.2 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_23 PF13384.6 CDW57140.1 - 0.16 11.8 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 Homeodomain-like domain SLX9 PF15341.6 CDW57142.1 - 0.25 11.8 5.2 0.77 10.2 5.2 1.9 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 PALP PF00291.25 CDW57143.1 - 1.7e-48 165.6 0.0 2.1e-48 165.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PEP-utilizers PF00391.23 CDW57143.1 - 0.12 12.1 0.1 5.5 6.8 0.0 2.7 2 0 0 2 2 2 0 PEP-utilising enzyme, mobile domain Transglut_core PF01841.19 CDW57143.1 - 0.16 12.4 0.0 0.38 11.2 0.0 1.6 2 0 0 2 2 2 0 Transglutaminase-like superfamily I-set PF07679.16 CDW57144.1 - 3.1e-38 129.7 0.9 2.1e-12 47.0 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW57144.1 - 5.2e-36 123.1 4.4 2.8e-15 56.7 0.2 4.1 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 CDW57144.1 - 1.6e-29 101.9 2.0 3e-10 40.2 0.1 3.5 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 CDW57144.1 - 2.1e-23 82.5 1.9 1.2e-08 35.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 CDW57144.1 - 7e-15 55.2 5.5 1.1e-05 25.6 0.0 4.7 4 2 0 4 4 4 3 Immunoglobulin V-set domain Ig_6 PF18452.1 CDW57144.1 - 1.3e-06 27.8 0.1 0.12 12.0 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain Izumo-Ig PF16706.5 CDW57144.1 - 0.00012 22.1 0.0 0.81 9.8 0.0 3.3 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 CDW57144.1 - 0.00017 21.6 0.0 1 9.5 0.0 3.3 3 0 0 3 3 3 2 C17orf99 Ig domain C2-set_2 PF08205.12 CDW57144.1 - 0.00022 21.2 0.4 0.034 14.2 0.0 3.4 3 1 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 CDW57144.1 - 0.0031 17.7 1.1 2.5 8.4 0.1 3.9 3 2 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Adeno_E3_CR1 PF02440.15 CDW57144.1 - 0.0042 16.8 0.2 0.0042 16.8 0.2 3.3 4 1 0 4 4 4 1 Adenovirus E3 region protein CR1 C2-set PF05790.15 CDW57144.1 - 0.012 15.8 0.1 11 6.3 0.0 3.9 4 0 0 4 4 4 0 Immunoglobulin C2-set domain Marek_A PF02124.15 CDW57144.1 - 0.02 14.7 0.2 1.7 8.4 0.0 2.9 3 0 0 3 3 3 0 Marek's disease glycoprotein A PulA_N1 PF17999.1 CDW57144.1 - 0.22 12.3 0.3 38 5.1 0.1 2.6 2 0 0 2 2 2 0 Pullulanase N1-terminal domain ERAP1_C PF11838.8 CDW57145.1 - 2.1e-52 178.6 7.4 9.5e-27 94.4 0.2 2.4 1 1 1 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CDW57145.1 - 3.3e-28 98.7 0.0 6.1e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CDW57145.1 - 3.7e-22 79.4 0.0 7.8e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain OppC_N PF12911.7 CDW57145.1 - 0.082 12.9 0.4 0.21 11.6 0.4 1.6 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Acetyltransf_10 PF13673.7 CDW57145.1 - 0.098 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain OCIA PF07051.11 CDW57147.1 - 4e-22 78.0 0.2 6.1e-22 77.5 0.2 1.2 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) TerB_N PF13208.6 CDW57147.1 - 0.15 11.8 0.2 0.25 11.0 0.2 1.3 1 0 0 1 1 1 0 TerB N-terminal domain SH2 PF00017.24 CDW57148.1 - 1.3e-11 44.4 0.0 0.014 15.5 0.0 4.1 4 0 0 4 4 4 3 SH2 domain Utp14 PF04615.13 CDW57149.1 - 9.6e-89 298.9 31.0 3.2e-56 191.4 24.3 2.0 1 1 0 2 2 2 2 Utp14 protein Rgp1 PF08737.10 CDW57149.1 - 0.07 12.3 2.1 0.12 11.5 2.1 1.3 1 0 0 1 1 1 0 Rgp1 G-alpha PF00503.20 CDW57150.1 - 2.7e-115 385.3 4.4 3.3e-115 385.1 4.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CDW57150.1 - 1.2e-14 54.1 1.1 3.3e-10 39.7 0.2 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW57150.1 - 1.2e-05 24.8 0.2 0.0037 16.7 0.1 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region TniB PF05621.11 CDW57150.1 - 0.0045 16.4 0.1 0.007 15.8 0.1 1.4 1 0 0 1 1 1 1 Bacterial TniB protein Roc PF08477.13 CDW57150.1 - 0.0051 17.0 0.0 0.99 9.6 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CDW57150.1 - 0.033 13.9 0.1 0.068 12.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 CDW57150.1 - 0.095 11.9 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Peptidase_M16 PF00675.20 CDW57151.1 - 5e-31 107.7 0.0 1.2e-30 106.5 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDW57151.1 - 2.1e-20 73.5 0.0 1.1e-18 67.9 0.0 2.3 1 1 1 2 2 2 1 Peptidase M16 inactive domain MvaI_BcnI PF15515.6 CDW57151.1 - 0.012 15.4 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 MvaI/BcnI restriction endonuclease family PQ-loop PF04193.14 CDW57152.1 - 1.3e-30 105.0 15.5 2e-18 65.9 6.2 2.8 2 1 1 3 3 3 2 PQ loop repeat Flu_B_M2 PF04772.12 CDW57152.1 - 0.017 15.3 1.3 0.35 11.1 0.1 2.6 2 1 1 3 3 3 0 Influenza B matrix protein 2 (BM2) Luteo_PO PF04662.13 CDW57152.1 - 0.046 13.4 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 Luteovirus P0 protein Rax2 PF12768.7 CDW57152.1 - 0.089 12.2 0.0 0.22 11.0 0.0 1.7 1 1 1 2 2 2 0 Cortical protein marker for cell polarity Prefoldin_2 PF01920.20 CDW57153.1 - 1e-18 67.2 15.9 1.4e-18 66.8 15.9 1.2 1 0 0 1 1 1 1 Prefoldin subunit AAA_assoc_C PF09821.9 CDW57153.1 - 0.00077 20.0 1.1 0.00077 20.0 1.1 1.8 1 1 1 2 2 2 1 C-terminal AAA-associated domain Rx_N PF18052.1 CDW57153.1 - 0.033 14.5 1.8 0.033 14.5 1.8 2.2 1 1 1 2 2 2 0 Rx N-terminal domain SlyX PF04102.12 CDW57153.1 - 0.063 13.9 5.1 0.063 13.9 5.1 2.5 2 1 0 2 2 2 0 SlyX DUF3958 PF13125.6 CDW57153.1 - 0.33 11.2 11.1 0.28 11.4 2.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3958) GAS PF13851.6 CDW57153.1 - 0.38 10.1 14.2 0.33 10.3 4.5 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1192 PF06698.11 CDW57153.1 - 0.4 10.8 4.1 0.43 10.7 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) Atg14 PF10186.9 CDW57153.1 - 0.59 9.2 8.2 0.73 8.9 8.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FlaC_arch PF05377.11 CDW57153.1 - 0.8 10.1 10.2 7.9 7.0 2.0 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DivIVA PF05103.13 CDW57153.1 - 0.92 9.6 13.3 0.17 12.0 2.2 2.3 2 1 0 2 2 2 0 DivIVA protein FAP206 PF12018.8 CDW57153.1 - 1.9 7.9 9.8 0.62 9.5 2.4 2.0 2 0 0 2 2 2 0 Domain of unknown function GPW_gp25 PF04965.14 CDW57153.1 - 3.2 7.6 7.4 1.6 8.6 4.1 1.9 2 0 0 2 2 2 0 Gene 25-like lysozyme PSS PF03034.15 CDW57154.1 - 5e-104 347.9 21.5 8.6e-104 347.1 21.5 1.4 1 0 0 1 1 1 1 Phosphatidyl serine synthase Adeno_GP19K PF04881.13 CDW57154.1 - 0.11 12.5 0.9 0.24 11.4 0.9 1.5 1 0 0 1 1 1 0 Adenovirus GP19K CbiM PF01891.16 CDW57154.1 - 7.1 6.4 11.7 0.3 10.9 0.8 3.1 3 0 0 3 3 3 0 Cobalt uptake substrate-specific transmembrane region PWI PF01480.17 CDW57155.1 - 5.5e-14 52.2 0.6 1.3e-13 51.0 0.6 1.7 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 CDW57155.1 - 6.9e-08 32.2 0.0 1.6e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TMEM214 PF10151.9 CDW57155.1 - 0.073 11.5 2.0 0.14 10.6 2.0 1.4 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator LpoB PF13036.6 CDW57155.1 - 0.1 12.5 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 Peptidoglycan-synthase activator LpoB DUF913 PF06025.12 CDW57155.1 - 2 7.3 5.0 3.2 6.6 5.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 CDW57155.1 - 8.4 5.0 7.1 11 4.7 7.1 1.3 1 0 0 1 1 1 0 Presenilin MRP-S28 PF10213.9 CDW57156.1 - 1.7e-19 70.5 0.1 2.9e-19 69.7 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein RGS_DHEX PF18148.1 CDW57156.1 - 0.15 12.2 0.9 0.45 10.7 0.9 1.7 1 1 0 1 1 1 0 Regulator of G-protein signalling DHEX domain DEAD PF00270.29 CDW57157.1 - 3.1e-43 147.6 0.0 7e-43 146.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW57157.1 - 1.8e-27 95.9 0.1 5.9e-25 87.8 0.1 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 CDW57157.1 - 8.1e-06 25.9 0.3 3.4e-05 23.9 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 CDW57157.1 - 3.3e-05 22.9 1.2 0.029 13.2 0.1 2.9 1 1 2 3 3 3 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 CDW57157.1 - 0.0059 16.9 0.9 0.1 12.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain Carbam_trans_N PF02543.15 CDW57157.1 - 0.069 12.8 0.1 0.17 11.5 0.1 1.6 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus COX7a PF02238.15 CDW57158.1 - 0.019 15.4 0.7 0.038 14.4 0.7 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII DAN PF03045.15 CDW57160.1 - 1.4e-28 99.2 6.9 2.6e-28 98.3 6.9 1.4 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 CDW57160.1 - 2.2e-05 24.7 5.7 4.5e-05 23.7 5.7 1.5 1 0 0 1 1 1 1 Cystine-knot domain PEHE PF15275.6 CDW57160.1 - 0.044 14.4 2.7 0.082 13.5 2.7 1.5 1 0 0 1 1 1 0 PEHE domain SMG1 PF15785.5 CDW57161.1 - 1.5e-11 43.4 2.9 9.5e-11 40.8 2.9 2.0 1 1 0 1 1 1 1 Serine/threonine-protein kinase smg-1 DnaG_DnaB_bind PF08278.11 CDW57161.1 - 0.041 14.5 0.1 0.15 12.7 0.1 2.0 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding FATC PF02260.20 CDW57162.1 - 1e-07 31.6 0.0 2.5e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 FATC domain TMF_TATA_bd PF12325.8 CDW57162.1 - 0.018 15.3 0.2 0.14 12.4 0.0 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding PEP-utilisers_N PF05524.13 CDW57162.1 - 0.1 12.7 1.7 0.86 9.8 0.1 2.8 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal Cas_DxTHG PF09455.10 CDW57162.1 - 3 7.4 7.8 9.3 5.7 0.1 3.2 3 0 0 3 3 3 0 CRISPR-associated (Cas) DxTHG family UQ_con PF00179.26 CDW57163.1 - 4.3e-11 42.6 0.0 5.3e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pkinase PF00069.25 CDW57164.1 - 6.1e-09 35.6 0.0 7.4e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57164.1 - 2.3e-08 33.7 0.0 2.9e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Calsequestrin PF01216.17 CDW57165.1 - 2.7e-56 191.3 3.0 2.7e-56 191.3 3.0 1.3 2 0 0 2 2 2 1 Calsequestrin Thioredoxin_6 PF13848.6 CDW57165.1 - 2.4e-12 47.2 1.2 5.8e-11 42.6 0.0 2.7 2 1 1 3 3 3 1 Thioredoxin-like domain Peptidase_C65 PF10275.9 CDW57167.1 - 1.1e-42 146.2 0.1 1.2e-42 146.1 0.1 1.0 1 0 0 1 1 1 1 Peptidase C65 Otubain DUF469 PF04320.14 CDW57167.1 - 0.059 14.2 0.2 0.099 13.5 0.2 1.3 1 0 0 1 1 1 0 Protein with unknown function (DUF469) FliD_N PF02465.18 CDW57168.1 - 0.002 18.8 1.0 0.002 18.8 1.0 4.3 4 0 0 4 4 4 1 Flagellar hook-associated protein 2 N-terminus zf-C3HC4_3 PF13920.6 CDW57169.1 - 1.1e-14 54.0 10.2 4.6e-14 52.0 10.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW57169.1 - 4.1e-07 29.8 10.9 4.1e-07 29.8 10.9 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CDW57169.1 - 0.00017 21.8 13.1 0.00017 21.8 13.1 2.6 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 CDW57169.1 - 0.003 17.5 10.7 0.012 15.6 10.7 2.1 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDW57169.1 - 0.007 16.2 12.1 0.017 15.0 12.1 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RabGAP-TBC PF00566.18 CDW57170.1 - 4.2e-50 170.4 0.1 2.8e-49 167.7 0.0 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DNA_primase_lrg PF04104.14 CDW57170.1 - 0.062 12.7 0.5 0.11 11.9 0.5 1.3 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit Packaging_FI PF14000.6 CDW57170.1 - 0.072 13.5 0.9 0.14 12.6 0.9 1.4 1 0 0 1 1 1 0 DNA packaging protein FI Cauli_AT PF03233.13 CDW57170.1 - 0.17 11.8 2.7 0.36 10.8 2.7 1.5 1 0 0 1 1 1 0 Aphid transmission protein AGTRAP PF06396.11 CDW57172.1 - 1.8e-18 66.8 4.7 2.2e-18 66.5 4.7 1.1 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) GRIP PF01465.20 CDW57173.1 - 4.5e-11 42.5 0.1 1e-10 41.4 0.1 1.7 1 0 0 1 1 1 1 GRIP domain HALZ PF02183.18 CDW57173.1 - 0.062 13.5 12.4 0.55 10.5 0.3 4.8 3 1 1 4 4 4 0 Homeobox associated leucine zipper UMP1 PF05348.11 CDW57173.1 - 0.1 12.9 0.4 0.28 11.4 0.4 1.8 1 0 0 1 1 1 0 Proteasome maturation factor UMP1 Baculo_PEP_C PF04513.12 CDW57173.1 - 0.16 12.0 1.4 0.66 10.0 0.7 2.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PI3K_P85_iSH2 PF16454.5 CDW57173.1 - 0.2 11.3 22.0 38 3.8 0.1 3.6 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Tup_N PF08581.10 CDW57173.1 - 0.41 11.0 5.6 0.84 10.0 0.7 3.4 3 1 1 4 4 4 0 Tup N-terminal NYD-SP28_assoc PF14775.6 CDW57173.1 - 0.78 9.9 6.1 0.21 11.7 0.5 2.9 3 0 0 3 3 3 0 Sperm tail C-terminal domain DivIC PF04977.15 CDW57173.1 - 1.1 9.1 7.3 4.3 7.2 1.0 3.6 3 0 0 3 3 3 0 Septum formation initiator APG6_N PF17675.1 CDW57173.1 - 2.3 8.8 26.2 0.82 10.2 1.6 4.2 4 0 0 4 4 4 0 Apg6 coiled-coil region HEAT PF02985.22 CDW57174.1 - 0.00029 20.8 7.8 36 5.0 0.2 7.8 8 0 0 8 8 8 0 HEAT repeat Cnd1 PF12717.7 CDW57174.1 - 0.00077 19.5 10.1 5.2 7.1 0.1 5.5 6 1 1 7 7 7 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDW57174.1 - 0.0027 18.1 6.9 4.4 7.8 0.2 5.5 5 1 1 6 6 6 1 HEAT repeats MgtE_N PF03448.17 CDW57174.1 - 0.064 13.9 2.0 0.18 12.4 0.3 2.7 3 0 0 3 3 3 0 MgtE intracellular N domain AT_hook PF02178.19 CDW57174.1 - 0.26 11.3 4.2 0.82 9.8 4.2 1.9 1 0 0 1 1 1 0 AT hook motif Myb_DNA-binding PF00249.31 CDW57175.1 - 3e-47 158.6 6.7 1e-16 60.8 0.2 4.9 5 0 0 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDW57175.1 - 3e-35 120.3 5.9 2.3e-11 43.8 0.0 5.4 3 2 3 6 6 6 5 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CDW57175.1 - 3.7e-06 27.1 8.3 0.31 11.2 0.3 5.3 2 2 3 5 5 5 2 SANT/Myb-like domain of DAMP1 SLIDE PF09111.10 CDW57175.1 - 1.4e-05 25.1 0.1 0.0024 17.9 0.0 3.6 1 1 2 4 4 4 1 SLIDE Myb_DNA-bind_4 PF13837.6 CDW57175.1 - 1.4e-05 25.3 9.6 0.11 12.9 0.4 5.4 3 2 2 5 5 5 2 Myb/SANT-like DNA-binding domain Rap1_C PF11626.8 CDW57175.1 - 2.5e-05 24.3 0.7 0.63 10.2 0.2 3.4 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_7 PF15963.5 CDW57175.1 - 7.9e-05 22.5 0.1 0.029 14.3 0.2 3.2 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_2 PF08914.11 CDW57175.1 - 0.065 13.4 0.0 1.1 9.5 0.1 2.6 2 0 0 2 2 2 0 Rap1 Myb domain HTH_AsnC-type PF13404.6 CDW57175.1 - 0.26 11.2 3.9 1 9.2 0.1 3.8 5 0 0 5 5 5 0 AsnC-type helix-turn-helix domain WD40 PF00400.32 CDW57176.1 - 1.8e-34 117.2 22.5 9e-06 26.3 0.0 11.5 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57176.1 - 2.3e-20 72.7 0.0 0.00061 20.0 0.1 8.1 3 2 6 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 CDW57176.1 - 2.1e-13 50.5 0.7 6.8e-13 48.9 0.7 1.9 1 1 0 1 1 1 1 Dip2/Utp12 Family eIF2A PF08662.11 CDW57176.1 - 8.8e-08 32.2 0.1 0.086 12.7 0.0 5.3 3 3 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDW57176.1 - 0.00025 20.1 0.1 1.3 7.9 0.0 4.8 5 1 1 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDW57176.1 - 0.0012 18.2 0.0 0.088 12.1 0.0 2.8 3 0 0 3 3 3 1 WD40-like domain Nup160 PF11715.8 CDW57176.1 - 0.013 14.2 0.2 0.044 12.4 0.0 1.9 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PD40 PF07676.12 CDW57176.1 - 0.014 15.4 0.9 2 8.4 0.0 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Utp13 PF08625.11 CDW57176.1 - 0.021 14.8 0.0 0.05 13.5 0.0 1.6 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain DUF1513 PF07433.11 CDW57176.1 - 0.027 13.6 0.1 0.53 9.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1513) Kelch_6 PF13964.6 CDW57176.1 - 0.058 13.7 4.4 17 5.9 0.0 4.4 4 0 0 4 4 3 0 Kelch motif WD40_3 PF15911.5 CDW57176.1 - 0.12 12.3 0.0 0.44 10.6 0.0 1.9 1 0 0 1 1 1 0 WD domain, G-beta repeat DUF1356 PF07092.12 CDW57177.1 - 1.2e-36 126.2 7.4 4.6e-35 121.0 1.9 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 CDW57177.1 - 0.00044 20.1 0.0 0.00069 19.5 0.0 1.2 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 CDW57177.1 - 0.019 15.1 0.3 0.034 14.3 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5351) DnaJ_CXXCXGXG PF00684.19 CDW57177.1 - 0.15 12.4 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 DnaJ central domain ARPC4 PF05856.12 CDW57178.1 - 5.3e-75 250.6 5.6 5.9e-75 250.5 5.6 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) PP2C PF00481.21 CDW57179.1 - 4.9e-47 160.7 0.1 9.8e-47 159.7 0.0 1.5 2 0 0 2 2 2 1 Protein phosphatase 2C PP2C_2 PF13672.6 CDW57179.1 - 2.9e-08 33.6 0.1 1.3e-07 31.5 0.0 2.1 2 1 0 2 2 2 1 Protein phosphatase 2C eIF-3_zeta PF05091.12 CDW57180.1 - 1.6e-189 631.2 0.0 2.8e-189 630.4 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 CDW57180.1 - 0.00048 19.7 0.0 0.0016 18.0 0.0 1.8 1 1 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus GCP_N_terminal PF17681.1 CDW57181.1 - 7.6e-34 117.7 0.1 1.1e-33 117.2 0.1 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal NYD-SP12_N PF15015.6 CDW57181.1 - 0.056 11.8 0.1 0.095 11.1 0.1 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal eIF3_subunit PF08597.10 CDW57181.1 - 0.18 11.7 0.7 0.27 11.1 0.7 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit SAM_Exu PF18609.1 CDW57181.1 - 0.3 11.2 1.2 0.49 10.5 0.1 1.9 2 0 0 2 2 2 0 Exuperantia SAM-like domain FtsJ PF01728.19 CDW57182.1 - 1.3e-46 158.9 0.0 1.5e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CDW57182.1 - 0.00038 20.3 0.0 0.75 9.6 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Peptidase_S28 PF05577.12 CDW57183.1 - 1.6e-76 257.8 3.0 4.3e-50 170.8 1.3 2.0 1 1 1 2 2 2 2 Serine carboxypeptidase S28 Hydrolase_4 PF12146.8 CDW57183.1 - 0.00018 20.8 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S37 PF05576.11 CDW57183.1 - 0.0023 16.7 0.1 0.0038 16.0 0.1 1.2 1 0 0 1 1 1 1 PS-10 peptidase S37 DUF2920 PF11144.8 CDW57183.1 - 0.0061 15.8 0.1 0.01 15.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Peptidase_S9 PF00326.21 CDW57183.1 - 0.0076 15.8 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CDW57183.1 - 0.013 15.2 0.2 0.035 13.7 0.1 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW57183.1 - 0.037 14.6 0.0 0.077 13.6 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family IFT57 PF10498.9 CDW57184.1 - 1.2 8.0 20.6 0.37 9.7 16.2 2.2 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 YjcZ PF13990.6 CDW57184.1 - 1.5 8.1 7.6 0.27 10.6 2.7 2.4 2 0 0 2 2 2 0 YjcZ-like protein GWT1 PF06423.12 CDW57185.1 - 8.1e-05 22.8 4.1 0.0015 18.7 0.1 2.6 2 1 1 3 3 3 2 GWT1 DUF1179 PF06678.11 CDW57185.1 - 0.21 11.6 2.2 0.36 10.8 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) Mito_fiss_reg PF05308.11 CDW57185.1 - 3.7 7.6 7.5 5.5 7.0 7.5 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator DRIM PF07539.12 CDW57186.1 - 1e-80 271.8 20.5 2.8e-80 270.4 20.5 1.8 1 0 0 1 1 1 1 Down-regulated in metastasis DUF3517 PF12030.8 CDW57186.1 - 0.003 16.5 0.4 0.014 14.3 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3517) MMS19_N PF14500.6 CDW57186.1 - 0.031 13.9 15.1 0.41 10.2 0.1 6.7 4 2 2 6 6 6 0 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.23 CDW57186.1 - 0.17 12.0 3.8 30 4.8 0.0 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Fib_alpha PF08702.10 CDW57186.1 - 0.29 11.3 4.6 0.72 10.0 3.3 2.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family HEAT PF02985.22 CDW57186.1 - 0.42 11.0 2.5 53 4.5 0.1 5.2 3 0 0 3 3 3 0 HEAT repeat YabA PF06156.13 CDW57186.1 - 7.2 7.3 6.1 4.4 8.0 1.5 2.9 2 0 0 2 2 2 0 Initiation control protein YabA Diphthamide_syn PF01866.17 CDW57187.1 - 1.7e-116 388.9 0.8 2.1e-116 388.6 0.8 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Ion_trans PF00520.31 CDW57188.1 - 0.0002 20.7 6.4 0.00027 20.3 6.4 1.1 1 0 0 1 1 1 1 Ion transport protein TMPIT PF07851.13 CDW57189.1 - 6.4e-103 344.4 23.6 1.2e-99 333.6 19.0 2.3 1 1 1 2 2 2 2 TMPIT-like protein AGTRAP PF06396.11 CDW57189.1 - 0.0069 16.2 1.1 0.019 14.8 0.6 1.8 1 1 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) Motilin_ghrelin PF04644.12 CDW57189.1 - 0.27 11.1 4.4 0.66 9.8 4.4 1.6 1 0 0 1 1 1 0 Motilin/ghrelin HSP90 PF00183.18 CDW57190.1 - 4.8e-83 279.8 8.8 4.5e-78 263.4 4.5 2.4 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 CDW57190.1 - 7.1e-13 48.6 0.1 1.3e-12 47.7 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CDW57190.1 - 1.9e-08 34.8 0.0 3.7e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sirohm_synth_C PF14823.6 CDW57190.1 - 0.05 13.3 0.1 2.9 7.6 0.0 2.7 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal NUDIX PF00293.28 CDW57190.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 NUDIX domain ATP-synt_C PF00137.21 CDW57191.1 - 6e-36 122.6 35.9 6.5e-23 80.8 13.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Man-6-P_recep PF02157.15 CDW57191.1 - 0.47 9.5 3.5 7.8 5.5 0.3 2.1 2 0 0 2 2 2 0 Mannose-6-phosphate receptor B12D PF06522.11 CDW57192.1 - 0.0005 19.8 0.1 0.0009 19.0 0.1 1.5 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Adaptin_N PF01602.20 CDW57193.1 - 5.7e-72 243.0 6.0 7.4e-72 242.6 6.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3B1_C PF14796.6 CDW57193.1 - 5.7e-26 91.5 0.0 1.2e-25 90.5 0.0 1.6 1 0 0 1 1 1 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Cnd1 PF12717.7 CDW57193.1 - 0.049 13.7 1.7 0.16 12.0 1.6 1.9 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Alpha_adaptinC2 PF02883.20 CDW57193.1 - 0.074 13.4 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 Adaptin C-terminal domain CDC45 PF02724.14 CDW57193.1 - 3.2 5.9 15.4 7 4.8 12.3 2.1 2 0 0 2 2 2 0 CDC45-like protein TUDOR PF00567.24 CDW57194.1 - 1.8e-05 24.8 0.0 3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Tudor domain DNase_NucA_NucB PF14040.6 CDW57194.1 - 0.025 15.0 1.1 0.047 14.1 1.1 1.5 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB Aa_trans PF01490.18 CDW57195.1 - 1.5e-18 66.8 22.3 6.8e-12 44.8 12.2 2.3 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CDW57195.1 - 0.0038 16.3 2.0 0.0038 16.3 2.0 4.0 4 0 0 4 4 4 2 Tryptophan/tyrosine permease family FGGY_C PF02782.16 CDW57196.1 - 6.2e-13 48.9 0.0 2.7e-10 40.3 0.0 2.6 3 0 0 3 3 3 2 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CDW57196.1 - 2.8e-09 36.9 0.0 0.0042 16.7 0.0 3.2 3 0 0 3 3 3 3 FGGY family of carbohydrate kinases, N-terminal domain Enamelin PF15362.6 CDW57198.1 - 1.2 7.3 4.2 1.7 6.9 4.2 1.0 1 0 0 1 1 1 0 Enamelin Ion_trans_2 PF07885.16 CDW57200.1 - 3.3e-33 113.5 18.5 5.6e-18 64.7 1.6 3.1 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 CDW57200.1 - 2e-06 27.2 6.4 0.0027 17.0 0.2 2.2 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 CDW57200.1 - 0.016 15.0 0.2 0.067 13.0 0.1 2.1 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain DUF2254 PF10011.9 CDW57200.1 - 0.31 9.8 2.6 0.19 10.5 0.4 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) Cytochrom_B561 PF03188.16 CDW57201.1 - 1.3e-36 125.8 5.9 1.3e-36 125.8 5.9 1.7 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF2721 PF11026.8 CDW57201.1 - 0.72 9.8 0.0 0.72 9.8 0.0 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF2721) Ni_hydr_CYTB PF01292.20 CDW57201.1 - 0.98 9.0 14.1 0.37 10.4 8.0 2.9 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 MgtE PF01769.16 CDW57201.1 - 3.1 8.2 13.7 2.3 8.6 4.7 3.1 1 1 2 3 3 3 0 Divalent cation transporter DUF962 PF06127.11 CDW57201.1 - 3.9 7.6 7.8 19 5.4 5.9 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF962) Pkinase PF00069.25 CDW57202.1 - 1.6e-58 198.2 0.0 2.1e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PH_3 PF14593.6 CDW57202.1 - 2.5e-40 136.8 0.0 5.1e-40 135.8 0.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 CDW57202.1 - 4.2e-27 95.1 0.0 7e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW57202.1 - 0.00033 19.7 0.0 0.0005 19.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW57202.1 - 0.00099 18.5 0.1 0.0045 16.3 0.1 1.9 1 1 0 1 1 1 1 Kinase-like Tweety PF04906.13 CDW57202.1 - 0.003 16.3 0.0 0.0038 16.0 0.0 1.1 1 0 0 1 1 1 1 Tweety APH PF01636.23 CDW57202.1 - 0.0043 17.0 0.0 0.012 15.5 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW57202.1 - 0.0065 15.8 0.1 0.016 14.6 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CDW57202.1 - 0.012 15.2 0.0 0.032 13.8 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 CDW57202.1 - 0.06 12.1 0.0 0.089 11.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pkinase_Tyr PF07714.17 CDW57203.1 - 9e-13 48.1 0.0 1e-12 47.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase EAP30 PF04157.16 CDW57204.1 - 8.3e-49 166.0 0.0 9.4e-49 165.8 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Aminotran_MocR PF12897.7 CDW57204.1 - 0.0016 17.3 0.0 0.0019 17.1 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Nif11 PF07862.11 CDW57204.1 - 0.0031 17.8 0.0 1.5 9.2 0.0 2.9 2 0 0 2 2 2 2 Nif11 domain Sigma70_r1_1 PF03979.14 CDW57204.1 - 0.017 15.1 0.0 0.041 14.0 0.0 1.6 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 DUF4896 PF16237.5 CDW57204.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4896) PSP PF04046.16 CDW57205.1 - 2.3e-19 69.0 1.5 5.4e-19 67.8 1.5 1.6 1 0 0 1 1 1 1 PSP zf-CCHC PF00098.23 CDW57205.1 - 1.5e-05 24.8 1.5 3.6e-05 23.6 1.5 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 CDW57205.1 - 0.023 14.5 0.7 0.023 14.5 0.7 1.9 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_4 PF13894.6 CDW57206.1 - 9.8e-06 26.0 63.5 0.11 13.4 0.1 9.6 10 0 0 10 10 10 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW57206.1 - 2.4e-05 24.5 19.0 1.1 9.7 0.8 6.7 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 CDW57206.1 - 0.00052 20.3 0.1 0.00052 20.3 0.1 7.3 8 0 0 8 8 8 2 Zinc-finger double domain zf-RRPl_C4 PF17026.5 CDW57206.1 - 0.0045 17.1 0.7 0.0045 17.1 0.7 2.9 2 1 1 3 3 3 1 Putative ribonucleoprotein zinc-finger pf C4 type zf-C2H2 PF00096.26 CDW57206.1 - 0.019 15.4 3.1 0.097 13.2 0.4 7.9 8 0 0 8 8 8 0 Zinc finger, C2H2 type zf-C2H2_9 PF16293.5 CDW57206.1 - 0.57 10.1 10.8 1.5 8.8 0.2 4.6 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 CDW57206.1 - 2.9 8.4 13.8 16 6.1 0.1 5.2 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain Ion_trans PF00520.31 CDW57209.1 - 6.1e-13 48.6 14.8 1.1e-12 47.8 14.8 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 CDW57209.1 - 8.1e-12 44.9 7.4 8.1e-12 44.9 7.4 2.2 2 0 0 2 2 2 1 Ion channel KCNQ_channel PF03520.14 CDW57209.1 - 3e-07 30.5 0.0 7.1e-07 29.2 0.0 1.5 1 1 0 1 1 1 1 KCNQ voltage-gated potassium channel IQ PF00612.27 CDW57209.1 - 0.08 12.8 0.2 0.08 12.8 0.2 2.2 2 0 0 2 2 2 0 IQ calmodulin-binding motif Yip1 PF04893.17 CDW57210.1 - 5.7e-10 39.2 14.5 7.4e-10 38.8 14.5 1.2 1 0 0 1 1 1 1 Yip1 domain Anoctamin PF04547.12 CDW57211.1 - 1.5e-104 350.4 18.4 1.9e-104 350.0 18.4 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 CDW57211.1 - 1.9e-36 125.9 2.8 6.6e-36 124.2 2.8 1.8 1 1 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin 7tm_1 PF00001.21 CDW57212.1 - 0.00012 21.5 13.6 0.00016 21.1 13.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sre PF03125.18 CDW57212.1 - 0.0073 15.5 9.4 0.013 14.7 8.4 2.1 1 1 0 1 1 1 1 C. elegans Sre G protein-coupled chemoreceptor Stevor PF17410.2 CDW57212.1 - 0.0074 15.9 1.0 0.0074 15.9 1.0 1.6 2 0 0 2 2 2 1 Subtelomeric Variable Open Reading frame 7TM_GPCR_Srab PF10292.9 CDW57212.1 - 0.0097 14.9 11.2 0.027 13.4 11.2 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR receptor class ab chemoreceptor Transket_pyr PF02779.24 CDW57213.1 - 2.7e-42 144.5 0.0 3.8e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDW57213.1 - 2.6e-40 137.1 0.1 4.8e-40 136.3 0.1 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain zf-CSL PF05207.13 CDW57213.1 - 8.9e-22 76.6 1.3 2e-21 75.4 1.3 1.6 1 0 0 1 1 1 1 CSL zinc finger PFOR_II PF17147.4 CDW57213.1 - 0.071 13.4 0.0 0.31 11.4 0.0 2.1 1 1 0 2 2 2 0 Pyruvate:ferredoxin oxidoreductase core domain II DUF4602 PF15375.6 CDW57214.1 - 1.6e-14 54.4 15.0 2e-14 54.1 15.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4602) DNA_binding_1 PF01035.20 CDW57215.1 - 1.7e-23 82.6 0.0 2.3e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Alpha-2-MRAP_C PF06401.11 CDW57215.1 - 0.17 11.8 0.1 0.28 11.1 0.1 1.3 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain TruD PF01142.18 CDW57216.1 - 5.8e-54 183.5 0.6 8e-31 107.3 0.0 3.5 1 1 2 4 4 4 3 tRNA pseudouridine synthase D (TruD) Fe_dep_repress PF01325.19 CDW57216.1 - 0.13 12.5 0.0 8.4 6.7 0.0 2.5 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain MFAP1 PF06991.11 CDW57217.1 - 9.8e-57 192.3 15.5 1.3e-56 191.8 15.5 1.2 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing Cwf_Cwc_15 PF04889.12 CDW57217.1 - 0.00051 19.9 10.5 0.00072 19.4 10.5 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein FYDLN_acid PF09538.10 CDW57217.1 - 0.43 11.3 5.7 0.8 10.4 5.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Spore_coat_CotO PF14153.6 CDW57217.1 - 0.9 9.4 7.5 1.3 8.9 7.5 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DeoC PF01791.9 CDW57218.1 - 1e-23 84.2 0.0 1.5e-23 83.6 0.0 1.2 1 0 0 1 1 1 1 DeoC/LacD family aldolase LMWPc PF01451.21 CDW57218.1 - 3e-21 76.3 0.0 5e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase PTH2 PF01981.16 CDW57218.1 - 7.3e-16 58.5 0.0 1.4e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 E1-E2_ATPase PF00122.20 CDW57219.1 - 3.6e-16 59.2 0.9 1.5e-15 57.2 0.6 2.0 2 0 0 2 2 2 1 E1-E2 ATPase MLANA PF14991.6 CDW57219.1 - 0.049 13.9 0.3 0.21 11.9 0.0 1.9 1 1 1 2 2 2 0 Protein melan-A DUF4231 PF14015.6 CDW57219.1 - 0.12 12.9 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Glyco_transf_7C PF02709.14 CDW57221.1 - 2.4e-24 84.8 0.0 4.8e-24 83.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_transf_7N PF13733.6 CDW57221.1 - 1.5e-19 70.0 0.1 2.8e-19 69.1 0.1 1.4 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_tranf_2_2 PF10111.9 CDW57221.1 - 0.034 13.6 0.2 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 Glycosyltransferase like family 2 Sema PF01403.19 CDW57222.1 - 2.1e-72 244.3 0.0 3.3e-72 243.6 0.0 1.3 1 0 0 1 1 1 1 Sema domain TSP_1 PF00090.19 CDW57222.1 - 4.3e-38 129.3 93.4 6.8e-11 42.2 4.2 7.2 7 0 0 7 7 7 6 Thrombospondin type 1 domain PSI PF01437.25 CDW57222.1 - 9.7e-07 29.2 3.0 9.7e-07 29.2 3.0 3.1 2 0 0 2 2 2 1 Plexin repeat Phosphodiest PF01663.22 CDW57223.1 - 1.3e-65 222.4 0.5 1.5e-65 222.1 0.5 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CDW57223.1 - 0.00013 21.5 0.2 0.12 11.8 0.0 2.2 1 1 0 2 2 2 2 Sulfatase Pribosyltran PF00156.27 CDW57224.1 - 6.9e-15 54.9 0.0 1.2e-14 54.1 0.0 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain GIT1_C PF12205.8 CDW57224.1 - 0.11 12.7 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term NIDO PF06119.14 CDW57225.1 - 5.8e-32 110.5 0.2 1.2e-17 64.6 0.1 2.7 2 0 0 2 2 2 2 Nidogen-like EGF_3 PF12947.7 CDW57225.1 - 9.1e-09 35.4 10.0 9.1e-09 35.4 10.0 3.6 3 1 0 3 3 3 2 EGF domain EGF_CA PF07645.15 CDW57225.1 - 1.7e-06 28.1 10.2 1.7e-06 28.1 10.2 3.6 3 1 0 3 3 3 1 Calcium-binding EGF domain EGF_MSP1_1 PF12946.7 CDW57225.1 - 5.6e-06 26.3 16.2 0.0046 17.0 7.4 3.0 2 0 0 2 2 2 2 MSP1 EGF domain 1 cEGF PF12662.7 CDW57225.1 - 9.1e-06 25.5 1.1 9.1e-06 25.5 1.1 3.4 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF PF00008.27 CDW57225.1 - 0.00073 19.8 7.9 0.00073 19.8 7.9 3.9 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 CDW57225.1 - 0.0077 16.8 5.5 0.0077 16.8 5.5 4.8 7 0 0 7 7 7 1 Human growth factor-like EGF NUDIX PF00293.28 CDW57226.1 - 2.1e-07 31.1 0.2 5.5e-07 29.7 0.2 1.8 1 1 0 1 1 1 1 NUDIX domain UQ_con PF00179.26 CDW57227.1 - 1.3e-40 138.3 0.0 2e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDW57227.1 - 0.00059 19.5 0.0 0.00075 19.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B zf-AN1 PF01428.16 CDW57228.1 - 2.6e-13 49.9 35.9 2e-08 34.2 15.6 3.1 2 1 1 3 3 3 2 AN1-like Zinc finger zf-RRN7 PF11781.8 CDW57228.1 - 6.8 6.5 12.4 4.7 7.0 0.7 3.5 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-RING_2 PF13639.6 CDW57229.1 - 1.3e-12 47.8 5.0 3e-12 46.7 5.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW57229.1 - 4.1e-11 42.5 5.3 4.1e-11 42.5 5.3 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDW57229.1 - 1.2e-10 40.9 1.9 1.2e-10 40.9 1.9 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 CDW57229.1 - 1.4e-09 37.7 4.4 3e-09 36.6 4.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDW57229.1 - 7e-09 35.8 4.5 2.6e-08 34.0 4.5 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDW57229.1 - 4.5e-06 26.6 5.2 1.4e-05 25.0 5.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDW57229.1 - 4.8e-05 23.2 3.2 4.8e-05 23.2 3.2 1.8 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDW57229.1 - 8.5e-05 22.3 4.2 0.00021 21.1 4.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CDW57229.1 - 0.0033 17.2 2.1 0.0073 16.1 2.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 CDW57229.1 - 0.012 15.6 2.1 0.04 14.0 2.1 1.9 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 CDW57229.1 - 0.062 13.2 3.6 0.13 12.2 3.6 1.6 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 CDW57229.1 - 0.16 11.6 3.9 0.32 10.6 3.9 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 CDW57229.1 - 0.17 12.3 4.2 0.31 11.4 4.2 1.5 1 0 0 1 1 1 0 RING-like domain 4PPT_N PF17837.1 CDW57229.1 - 0.25 11.5 0.9 0.41 10.8 0.1 1.8 2 0 0 2 2 1 0 4'-phosphopantetheinyl transferase N-terminal domain RINGv PF12906.7 CDW57229.1 - 0.27 11.4 2.9 0.65 10.2 2.9 1.7 1 1 0 1 1 1 0 RING-variant domain zf-ANAPC11 PF12861.7 CDW57229.1 - 0.46 10.6 8.2 0.1 12.6 4.3 2.0 2 1 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 CDW57229.1 - 0.47 10.6 3.6 1.4 9.1 3.6 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger FANCL_C PF11793.8 CDW57229.1 - 0.55 10.4 6.9 0.11 12.7 2.7 2.0 2 1 0 2 2 2 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 CDW57229.1 - 2.1 8.5 11.9 0.12 12.5 4.9 2.5 2 1 1 3 3 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CDW57229.1 - 10 6.0 8.0 2.4 8.0 3.2 2.2 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain MGAT2 PF05060.14 CDW57230.1 - 2.2e-121 405.2 4.1 8.7e-121 403.2 4.1 1.8 1 1 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) Glycos_transf_2 PF00535.26 CDW57230.1 - 0.15 11.8 0.1 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 2 Bestrophin PF01062.21 CDW57231.1 - 2.4e-87 293.1 5.7 2.8e-87 292.8 5.7 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Nore1-SARAH PF16517.5 CDW57231.1 - 0.051 13.5 0.9 8.3 6.4 1.7 2.4 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Na_H_antiporter PF03553.14 CDW57231.1 - 0.16 11.1 2.7 0.12 11.6 0.3 1.8 2 0 0 2 2 2 0 Na+/H+ antiporter family Neur_chan_LBD PF02931.23 CDW57232.1 - 4.7e-21 75.2 0.4 6.2e-21 74.8 0.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain IL17 PF06083.11 CDW57233.1 - 7.8e-14 51.9 2.2 1.1e-13 51.4 2.2 1.2 1 0 0 1 1 1 1 Interleukin-17 BCIP PF13862.6 CDW57234.1 - 2.5e-21 76.4 0.1 3.6e-21 75.9 0.1 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Ank_4 PF13637.6 CDW57235.1 - 7.7e-105 342.0 41.5 4.2e-13 49.5 0.2 16.2 6 5 11 17 17 17 16 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW57235.1 - 2.4e-98 320.9 26.1 2.4e-10 40.4 0.1 14.7 6 5 10 16 16 16 14 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW57235.1 - 1e-97 320.8 18.7 1.1e-15 58.0 0.0 10.0 6 4 4 10 10 10 10 Ankyrin repeats (3 copies) Ank PF00023.30 CDW57235.1 - 1.9e-87 284.2 32.5 5.3e-06 26.6 0.0 17.4 18 1 0 18 18 18 14 Ankyrin repeat Ank_3 PF13606.6 CDW57235.1 - 6.8e-87 274.9 24.7 1.1e-05 25.4 0.0 18.4 19 0 0 19 19 19 15 Ankyrin repeat PARP PF00644.20 CDW57235.1 - 1.8e-21 76.6 0.9 6.4e-21 74.8 0.9 1.8 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_1 PF00536.30 CDW57235.1 - 3.2e-05 24.3 0.4 8.1e-05 23.0 0.4 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW57235.1 - 0.00012 22.2 0.3 0.0006 19.9 0.3 2.2 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) AA_permease_2 PF13520.6 CDW57236.1 - 1.4e-67 228.4 41.2 1.7e-67 228.2 41.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW57236.1 - 2.9e-30 105.3 37.7 5.1e-30 104.5 37.7 1.4 1 1 0 1 1 1 1 Amino acid permease C2 PF00168.30 CDW57237.1 - 1.6e-05 25.1 0.0 1.9e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain 2OG-FeII_Oxy_3 PF13640.6 CDW57237.1 - 0.091 13.7 0.0 0.17 12.8 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily I-set PF07679.16 CDW57238.1 - 7.2e-18 64.5 0.0 8.8e-18 64.2 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW57238.1 - 3.1e-12 46.9 0.1 5.1e-12 46.2 0.0 1.4 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 CDW57238.1 - 8.3e-09 35.5 0.0 9.4e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 CDW57238.1 - 1.3e-05 25.3 0.1 0.00035 20.7 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_2 PF13895.6 CDW57238.1 - 1.7e-05 25.0 0.1 2.8e-05 24.4 0.1 1.4 1 1 0 1 1 1 1 Immunoglobulin domain C2-set_2 PF08205.12 CDW57238.1 - 0.0079 16.2 0.0 0.01 15.9 0.0 1.4 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 CDW57238.1 - 0.018 15.2 0.0 0.02 15.1 0.0 1.1 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 PDEase_I PF00233.19 CDW57240.1 - 2.1e-48 165.1 0.8 2.9e-38 132.0 0.8 2.0 1 1 1 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase 7tm_2 PF00002.24 CDW57241.1 - 1.9e-54 184.5 19.0 1.9e-54 184.5 19.0 1.9 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 CDW57241.1 - 9.9e-10 38.6 0.7 2.8e-09 37.1 0.7 1.8 1 0 0 1 1 1 1 Hormone receptor domain Neur_chan_LBD PF02931.23 CDW57242.1 - 1e-32 113.4 4.0 1.4e-32 112.9 4.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain SnoaL_2 PF12680.7 CDW57243.1 - 5.5e-05 23.8 0.0 6.7e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CDW57243.1 - 0.043 14.2 0.0 0.051 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) NTF2 PF02136.20 CDW57243.1 - 0.11 13.1 0.0 0.13 12.8 0.0 1.1 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain Tubulin PF00091.25 CDW57243.1 - 0.13 12.5 0.0 0.15 12.3 0.0 1.1 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain Pescadillo_N PF06732.11 CDW57244.1 - 2.4e-100 335.6 7.7 4.2e-57 193.8 0.1 2.3 2 0 0 2 2 2 2 Pescadillo N-terminus BRCT_2 PF16589.5 CDW57244.1 - 2e-11 44.1 0.0 3.9e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CDW57244.1 - 9.5e-06 25.9 0.0 3e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CDW57244.1 - 0.026 14.8 0.0 0.14 12.4 0.0 2.3 2 1 0 2 2 2 0 DNA ligase 3 BRCT domain Ribosomal_L6 PF00347.23 CDW57245.1 - 6.3e-25 87.7 2.8 2e-13 50.8 1.3 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 SLC12 PF03522.15 CDW57246.1 - 1.1e-110 370.6 1.5 1.4e-110 370.2 1.5 1.1 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.21 CDW57246.1 - 2.6e-101 339.6 33.6 3.3e-101 339.2 33.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_N PF08403.10 CDW57246.1 - 0.0024 17.3 0.0 0.0053 16.2 0.0 1.5 1 0 0 1 1 1 1 Amino acid permease N-terminal DEAD PF00270.29 CDW57247.1 - 1e-30 106.8 0.0 3.6e-30 105.0 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW57247.1 - 9.7e-24 83.9 0.0 1.9e-23 82.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CDW57247.1 - 1.3e-11 44.6 0.1 3.1e-11 43.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CDW57247.1 - 0.0018 18.3 0.0 0.0082 16.2 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit RA PF00788.23 CDW57248.1 - 1.2e-38 131.6 0.1 4.2e-20 72.2 0.0 2.8 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain DIL PF01843.19 CDW57248.1 - 8.1e-26 90.3 3.7 2.7e-25 88.6 3.7 2.0 1 0 0 1 1 1 1 DIL domain MID_pPIWI_RE PF18157.1 CDW57248.1 - 0.2 11.9 2.1 2.1 8.6 0.6 2.9 2 1 1 3 3 3 0 MID domain of pPIWI_RE DUF733 PF05306.11 CDW57248.1 - 0.79 10.1 5.2 0.84 10.0 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF733) Trypsin PF00089.26 CDW57250.1 - 4.4e-74 249.0 0.0 2.4e-40 138.7 0.0 3.3 2 1 1 3 3 3 3 Trypsin DUF1986 PF09342.11 CDW57250.1 - 1.1e-11 45.1 0.2 2.5e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 CDW57250.1 - 2.1e-11 45.0 0.0 3.9e-06 27.8 0.0 3.5 2 1 1 3 3 3 2 Trypsin-like peptidase domain WD40 PF00400.32 CDW57250.1 - 8.2e-06 26.5 10.4 0.082 13.8 0.1 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat DUF316 PF03761.15 CDW57250.1 - 0.012 15.2 0.0 0.38 10.3 0.0 2.3 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 Trypsin PF00089.26 CDW57251.1 - 1.9e-33 116.1 0.0 2.7e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW57251.1 - 2.7e-05 25.1 0.0 5.3e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW57251.1 - 0.068 13.5 0.0 0.18 12.2 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) DUF2375 PF09558.10 CDW57251.1 - 0.071 13.1 0.0 2.6 8.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2375) Histone PF00125.24 CDW57251.1 - 0.16 12.3 0.0 0.31 11.4 0.0 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Trypsin PF00089.26 CDW57252.1 - 2.1e-42 145.4 0.0 2.7e-42 145.1 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW57252.1 - 3e-06 28.2 0.0 4.8e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW57252.1 - 0.00051 20.4 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin PF00089.26 CDW57253.1 - 1.1e-23 84.2 0.0 1.5e-23 83.8 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 CDW57253.1 - 0.0017 18.7 0.0 0.0067 16.8 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) P19Arf_N PF07392.12 CDW57253.1 - 0.005 17.3 0.6 0.12 12.9 0.3 2.3 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus Trypsin_2 PF13365.6 CDW57253.1 - 0.043 14.7 0.0 0.062 14.2 0.0 1.3 1 0 0 1 1 1 0 Trypsin-like peptidase domain Trypsin PF00089.26 CDW57254.1 - 2.1e-11 44.1 0.1 2.4e-11 43.9 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin PF00089.26 CDW57255.1 - 2.7e-31 109.1 0.0 3.4e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF316 PF03761.15 CDW57255.1 - 0.0026 17.4 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.6 CDW57255.1 - 0.0054 17.6 0.0 0.0084 17.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW57255.1 - 0.026 14.9 0.0 0.049 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Trypsin PF00089.26 CDW57256.1 - 5.1e-40 137.6 0.0 6.3e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW57256.1 - 6.8e-05 23.8 0.0 0.00012 23.0 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW57256.1 - 0.022 15.1 0.0 0.051 14.0 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) WD40 PF00400.32 CDW57257.1 - 1.1e-10 41.9 6.6 1.5e-05 25.6 0.0 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57257.1 - 3e-05 24.2 2.5 0.00065 20.0 0.2 3.3 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW57257.1 - 0.0038 17.1 0.2 0.029 14.3 0.1 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A CAF1C_H4-bd PF12265.8 CDW57257.1 - 0.021 15.1 0.0 0.056 13.7 0.0 1.6 1 0 0 1 1 1 0 Histone-binding protein RBBP4 or subunit C of CAF1 complex FLYWCH PF04500.16 CDW57258.1 - 1.6e-13 50.6 4.0 2.4e-13 50.0 4.0 1.2 1 0 0 1 1 1 1 FLYWCH zinc finger domain SGT1 PF07093.11 CDW57259.1 - 8.8e-135 450.4 2.1 1.1e-134 450.1 2.1 1.0 1 0 0 1 1 1 1 SGT1 protein Transposase_mut PF00872.18 CDW57259.1 - 0.023 13.6 0.0 0.044 12.6 0.0 1.5 1 1 0 1 1 1 0 Transposase, Mutator family B9-C2 PF07162.11 CDW57260.1 - 1.9e-46 158.4 0.1 2.1e-46 158.2 0.1 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Zip PF02535.22 CDW57261.1 - 2.7e-40 138.6 8.9 2.9e-31 108.9 10.3 2.1 1 1 1 2 2 2 2 ZIP Zinc transporter DEAD_2 PF06733.15 CDW57263.1 - 1.8e-48 164.5 0.1 3.1e-48 163.7 0.1 1.4 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 CDW57263.1 - 3e-41 141.4 1.3 5.4e-41 140.6 0.1 2.1 3 0 0 3 3 3 1 Helicase C-terminal domain HBB PF06777.11 CDW57263.1 - 4.4e-39 134.2 0.7 2.1e-33 115.6 0.1 2.6 2 1 0 2 2 2 2 Helical and beta-bridge domain ResIII PF04851.15 CDW57263.1 - 0.0055 16.7 0.1 0.088 12.8 0.1 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 CDW57263.1 - 0.039 12.7 0.1 0.094 11.4 0.1 1.8 1 1 0 1 1 1 0 SNF2 family N-terminal domain AAA_22 PF13401.6 CDW57263.1 - 0.06 13.6 1.7 7 6.9 0.1 3.3 3 0 0 3 3 3 0 AAA domain DEAD PF00270.29 CDW57263.1 - 0.18 11.6 0.1 3.2 7.5 0.0 2.3 2 0 0 2 2 2 0 DEAD/DEAH box helicase TFIIF_beta PF02270.15 CDW57264.1 - 1.3e-22 79.7 0.3 3.3e-22 78.4 0.3 1.7 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 CDW57264.1 - 6.2e-14 52.8 0.0 6.6e-12 46.3 0.0 2.6 2 1 0 2 2 2 1 TFIIF, beta subunit N-terminus PhoU_div PF01865.16 CDW57264.1 - 0.089 12.1 0.4 0.19 11.1 0.3 1.5 1 1 1 2 2 2 0 Protein of unknown function DUF47 RCC1 PF00415.18 CDW57265.1 - 3.4e-36 123.6 12.5 1.7e-10 41.3 0.3 7.2 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDW57265.1 - 1.2e-30 104.6 33.3 6.8e-09 35.3 1.6 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Arrestin_N PF00339.29 CDW57267.1 - 3.2e-21 75.9 1.2 4.6e-21 75.4 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CDW57267.1 - 4.3e-10 40.2 0.9 3.3e-09 37.3 0.5 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain CcmE PF03100.15 CDW57267.1 - 0.0012 18.8 0.1 0.0031 17.5 0.1 1.6 1 0 0 1 1 1 1 CcmE Rgp1 PF08737.10 CDW57267.1 - 0.046 12.9 0.5 0.088 12.0 0.3 1.6 1 1 1 2 2 2 0 Rgp1 RA PF00788.23 CDW57267.1 - 0.13 13.0 0.2 0.35 11.6 0.2 1.7 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain Patched PF02460.18 CDW57268.1 - 5.4e-73 246.4 28.8 2e-51 175.1 2.4 2.4 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 CDW57268.1 - 3.4e-49 166.6 12.1 3.4e-49 166.6 12.1 4.0 4 1 1 5 5 5 2 Sterol-sensing domain of SREBP cleavage-activation NPC1_N PF16414.5 CDW57268.1 - 2.8e-18 66.4 2.4 4.9e-18 65.6 2.4 1.4 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Folate_carrier PF01770.18 CDW57269.1 - 1.5e-81 274.2 31.5 8.1e-80 268.6 31.5 2.6 1 1 0 1 1 1 1 Reduced folate carrier IBR PF01485.21 CDW57270.1 - 8.2e-20 70.8 29.5 4.9e-15 55.5 7.8 4.0 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 CDW57270.1 - 0.00097 18.9 3.2 0.00097 18.9 3.2 5.4 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW57270.1 - 0.0016 18.7 3.8 0.0016 18.7 3.8 4.9 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 CDW57270.1 - 0.0018 18.1 6.1 0.0018 18.1 6.1 5.1 3 2 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW57270.1 - 0.0065 16.5 4.8 0.0065 16.5 4.8 4.2 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CDW57270.1 - 0.019 15.1 3.7 0.019 15.1 3.7 4.8 4 1 0 4 4 4 0 zinc finger of C3HC4-type, RING Zona_pellucida PF00100.23 CDW57271.1 - 2.5e-12 47.2 0.7 5.1e-12 46.1 0.7 1.5 1 1 0 1 1 1 1 Zona pellucida-like domain Fer4_20 PF14691.6 CDW57271.1 - 0.048 13.4 0.2 0.096 12.5 0.2 1.5 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster ABC_tran PF00005.27 CDW57272.1 - 3.3e-32 111.8 0.0 5.5e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDW57272.1 - 3.9e-31 108.7 11.2 5.7e-31 108.2 11.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDW57272.1 - 1.4e-06 28.0 1.1 0.00013 21.5 1.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDW57272.1 - 4.4e-05 23.9 0.1 0.00012 22.5 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CDW57272.1 - 0.00012 22.3 0.1 0.00099 19.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW57272.1 - 0.0018 17.9 0.0 0.0088 15.8 0.1 2.1 2 0 0 2 2 1 1 P-loop containing region of AAA domain DEAD PF00270.29 CDW57272.1 - 0.0044 16.8 0.0 0.011 15.5 0.0 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_5 PF07728.14 CDW57272.1 - 0.012 15.6 0.0 0.13 12.2 0.0 2.5 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 CDW57272.1 - 0.014 15.4 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 CDW57272.1 - 0.015 15.8 0.0 0.044 14.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain IstB_IS21 PF01695.17 CDW57272.1 - 0.02 14.6 0.1 0.8 9.4 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.6 CDW57272.1 - 0.024 14.8 0.0 0.061 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CDW57272.1 - 0.037 13.1 0.0 0.064 12.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_21 PF13304.6 CDW57272.1 - 0.038 13.8 0.1 0.093 12.5 0.1 1.6 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Cytidylate_kin PF02224.18 CDW57272.1 - 0.042 13.6 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 CDW57272.1 - 0.077 13.4 0.3 1.1 9.7 0.3 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDW57272.1 - 0.081 12.5 0.0 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CDW57272.1 - 0.095 12.8 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain SbcCD_C PF13558.6 CDW57272.1 - 0.1 12.8 0.1 1.2 9.4 0.1 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit NTPase_1 PF03266.15 CDW57272.1 - 0.11 12.4 0.4 12 5.7 0.1 2.4 2 0 0 2 2 2 0 NTPase MMR_HSR1 PF01926.23 CDW57272.1 - 0.11 12.5 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 CDW57272.1 - 0.17 11.6 0.0 0.66 9.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW57272.1 - 0.19 11.4 0.0 0.56 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Nkap_C PF06047.11 CDW57273.1 - 8.7e-48 160.7 3.5 8.7e-48 160.7 3.5 2.1 2 1 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain DIX PF00778.17 CDW57273.1 - 0.075 12.9 0.7 2.8 7.8 0.1 2.3 2 0 0 2 2 2 0 DIX domain DDHD PF02862.17 CDW57273.1 - 0.23 11.6 4.9 0.047 13.9 1.5 1.5 2 0 0 2 2 2 0 DDHD domain GAGA_bind PF06217.12 CDW57273.1 - 1.2 9.3 8.2 0.2 11.9 3.6 1.7 2 0 0 2 2 2 0 GAGA binding protein-like family SRP40_C PF05022.12 CDW57274.1 - 1.3e-21 77.2 4.4 1.3e-21 77.2 4.4 3.0 2 0 0 2 2 2 1 SRP40, C-terminal domain RasGEF PF00617.19 CDW57275.1 - 8.7e-43 146.6 0.3 2.2e-42 145.3 0.3 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CDW57275.1 - 7.3e-12 45.5 0.1 2.4e-11 43.8 0.1 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif Myf5 PF12232.8 CDW57275.1 - 0.13 13.1 0.2 0.4 11.5 0.2 1.9 1 0 0 1 1 1 0 Myogenic determination factor 5 Asp PF00026.23 CDW57276.1 - 1.8e-118 395.6 0.3 2.1e-118 395.3 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CDW57276.1 - 2.3e-11 44.2 0.2 1.3e-09 38.6 0.2 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CDW57276.1 - 0.00043 20.1 0.0 0.0021 17.9 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Piwi PF02171.17 CDW57277.1 - 3.6e-91 305.5 0.1 6.5e-91 304.7 0.1 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 CDW57277.1 - 6.9e-14 51.8 0.0 1.3e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 CDW57277.1 - 4.8e-10 39.0 0.4 1.2e-09 37.7 0.0 1.9 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoN PF16486.5 CDW57277.1 - 8e-09 36.2 0.1 1.4e-08 35.4 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 CDW57277.1 - 3e-08 33.9 0.0 2e-07 31.2 0.0 2.4 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoMid PF16487.5 CDW57277.1 - 2.2e-07 31.0 0.0 6.1e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 Mid domain of argonaute FXa_inhibition PF14670.6 CDW57279.1 - 9.6e-43 144.2 150.1 1.2e-09 38.3 12.5 11.0 10 0 0 10 10 10 7 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 CDW57279.1 - 2e-31 107.9 138.5 6.1e-08 32.7 8.5 11.0 9 2 1 10 10 10 6 Calcium-binding EGF domain cEGF PF12662.7 CDW57279.1 - 7.9e-31 105.6 92.7 9.2e-11 41.5 4.3 11.9 11 1 1 12 12 12 7 Complement Clr-like EGF-like Ephrin_rec_like PF07699.13 CDW57279.1 - 1.6e-23 82.2 27.5 7e-11 41.7 3.2 5.2 5 0 0 5 5 5 3 Putative ephrin-receptor like CUB PF00431.20 CDW57279.1 - 6.5e-11 42.5 0.1 1.9e-10 41.0 0.0 1.9 2 0 0 2 2 2 1 CUB domain EGF PF00008.27 CDW57279.1 - 9e-11 41.9 125.0 0.00079 19.7 10.3 10.2 10 0 0 10 10 10 6 EGF-like domain EGF_3 PF12947.7 CDW57279.1 - 2e-08 34.3 121.7 3.3e-06 27.2 7.2 9.9 9 0 0 9 9 9 6 EGF domain EGF_MSP1_1 PF12946.7 CDW57279.1 - 2.5e-06 27.4 3.2 2.5e-06 27.4 3.2 9.6 9 0 0 9 9 9 2 MSP1 EGF domain 1 OCRE PF17780.1 CDW57279.1 - 0.18 11.8 0.8 0.64 10.1 0.1 2.2 3 0 0 3 3 3 0 OCRE domain hEGF PF12661.7 CDW57279.1 - 1.5 9.6 109.4 0.078 13.6 3.2 12.2 10 2 0 10 10 10 0 Human growth factor-like EGF VWC PF00093.18 CDW57280.1 - 1.5e-13 50.8 33.9 1.1e-08 35.2 11.3 4.0 3 1 1 4 4 4 2 von Willebrand factor type C domain EGF_CA PF07645.15 CDW57280.1 - 1.6e-08 34.6 6.7 1.6e-08 34.6 6.7 4.0 4 0 0 4 4 4 2 Calcium-binding EGF domain cEGF PF12662.7 CDW57280.1 - 2e-06 27.6 17.8 0.0011 18.8 2.8 4.5 4 0 0 4 4 4 2 Complement Clr-like EGF-like EGF_3 PF12947.7 CDW57280.1 - 1.4e-05 25.2 21.7 2.4e-05 24.5 9.9 4.2 4 1 0 4 4 4 2 EGF domain hEGF PF12661.7 CDW57280.1 - 0.00027 21.5 6.5 0.00027 21.5 6.5 5.1 4 0 0 4 4 4 2 Human growth factor-like EGF EGF PF00008.27 CDW57280.1 - 0.00037 20.7 23.8 0.0016 18.7 6.9 5.1 7 1 0 7 7 7 2 EGF-like domain Laminin_G_2 PF02210.24 CDW57280.1 - 0.0049 17.4 0.1 0.01 16.4 0.1 1.5 1 0 0 1 1 1 1 Laminin G domain TILa PF12714.7 CDW57280.1 - 0.011 15.6 6.0 0.011 15.6 6.0 4.7 1 1 2 4 4 4 0 TILa domain FXa_inhibition PF14670.6 CDW57280.1 - 0.026 14.8 7.1 0.026 14.8 7.1 4.5 3 1 0 3 3 3 0 Coagulation Factor Xa inhibitory site CK2S PF15011.6 CDW57280.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Casein Kinase 2 substrate p450 PF00067.22 CDW57281.1 - 1.3e-60 205.4 0.1 1.2e-53 182.6 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 p450 PF00067.22 CDW57282.1 - 5.7e-61 206.7 0.0 1.5e-55 188.8 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Xol-1_N PF09108.10 CDW57283.1 - 0.015 15.2 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal Pkinase PF00069.25 CDW57284.1 - 1.3e-19 70.6 0.1 6.8e-09 35.5 0.0 2.7 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57284.1 - 0.0015 17.8 0.0 0.051 12.8 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDW57285.1 - 6.7e-68 228.9 0.0 8.9e-68 228.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57285.1 - 8.7e-31 107.1 0.0 1.2e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW57285.1 - 8.3e-10 38.5 0.0 6e-05 22.5 0.0 3.1 2 1 1 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 CDW57285.1 - 3.4e-05 22.8 0.0 0.01 14.6 0.0 2.9 3 0 0 3 3 3 2 Fungal protein kinase FTA2 PF13095.6 CDW57285.1 - 0.00032 20.4 0.0 0.17 11.5 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDW57285.1 - 0.00066 19.1 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Erf4 PF10256.9 CDW57286.1 - 0.0017 18.4 0.2 0.02 15.0 0.1 2.5 1 1 1 2 2 2 1 Golgin subfamily A member 7/ERF4 family DUF1154 PF06631.11 CDW57286.1 - 1.9 8.6 7.1 0.52 10.4 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) RabGAP-TBC PF00566.18 CDW57288.1 - 8.3e-51 172.7 1.4 8.3e-51 172.7 1.4 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.29 CDW57288.1 - 9.1e-10 39.0 0.0 3.8e-09 37.0 0.0 2.1 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 CDW57288.1 - 1.3e-06 28.4 0.0 4.4e-06 26.7 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CDW57288.1 - 2.8e-06 27.5 0.0 1.1e-05 25.6 0.0 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain UPF0242 PF06785.11 CDW57288.1 - 0.13 12.4 22.1 0.026 14.6 15.5 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PH_13 PF16652.5 CDW57288.1 - 0.13 12.1 1.6 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain DUF848 PF05852.11 CDW57288.1 - 0.49 10.5 6.1 12 6.0 1.8 2.6 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) PI3K_P85_iSH2 PF16454.5 CDW57288.1 - 0.62 9.6 16.6 0.054 13.1 10.9 2.1 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FapA PF03961.13 CDW57288.1 - 0.77 8.3 3.5 1.5 7.3 3.5 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A DivIVA PF05103.13 CDW57288.1 - 0.82 9.8 14.0 15 5.7 9.6 3.1 1 1 1 2 2 2 0 DivIVA protein CorA PF01544.18 CDW57288.1 - 0.89 8.8 10.2 2 7.6 7.5 2.4 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein ATG16 PF08614.11 CDW57288.1 - 1.1 9.5 25.8 12 6.1 2.6 3.6 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) Rootletin PF15035.6 CDW57288.1 - 1.1 9.3 15.9 0.13 12.3 10.3 2.2 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF4407 PF14362.6 CDW57288.1 - 1.1 8.5 5.4 2.5 7.4 5.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NDUF_B5 PF09781.9 CDW57289.1 - 9.5e-29 100.3 2.3 1.3e-28 99.9 2.3 1.3 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit Sec2p PF06428.11 CDW57290.1 - 0.00021 21.2 1.2 0.00021 21.2 1.2 2.7 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p Tmemb_cc2 PF10267.9 CDW57290.1 - 0.06 12.5 2.3 0.088 11.9 2.3 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein GIT1_C PF12205.8 CDW57290.1 - 0.11 12.6 2.4 0.2 11.8 0.2 2.3 2 0 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF4200 PF13863.6 CDW57290.1 - 0.13 12.7 3.9 0.24 11.8 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Yippee-Mis18 PF03226.14 CDW57291.1 - 3.4e-11 43.3 0.1 6.4e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LON_substr_bdg PF02190.16 CDW57291.1 - 1.1e-07 32.0 0.0 1.6e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain RIG-I_C-RD PF11648.8 CDW57291.1 - 0.099 12.9 0.2 6.9 6.9 0.0 2.6 2 0 0 2 2 2 0 C-terminal domain of RIG-I DUF5472 PF17566.2 CDW57291.1 - 0.13 12.3 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5472) 5-FTHF_cyc-lig PF01812.20 CDW57292.1 - 4e-47 160.5 0.0 4.5e-47 160.3 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family DUF842 PF05811.13 CDW57293.1 - 3.7e-34 117.3 16.3 4e-34 117.1 16.3 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Resolvase PF00239.21 CDW57293.1 - 0.02 15.0 0.3 0.031 14.4 0.3 1.3 1 0 0 1 1 1 0 Resolvase, N terminal domain Vicilin_N PF04702.12 CDW57293.1 - 0.032 14.0 16.8 0.28 11.0 17.2 1.8 1 1 1 2 2 2 0 Vicilin N terminal region ApoLp-III PF07464.11 CDW57293.1 - 0.065 13.3 0.7 0.18 11.9 0.9 1.6 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Dopey_N PF04118.14 CDW57293.1 - 0.07 12.2 0.6 0.077 12.1 0.6 1.0 1 0 0 1 1 1 0 Dopey, N-terminal Hexokinase_1 PF00349.21 CDW57293.1 - 0.071 13.0 0.0 0.087 12.7 0.0 1.1 1 0 0 1 1 1 0 Hexokinase MFS_1 PF07690.16 CDW57294.1 - 8.7e-55 186.1 27.5 6.5e-52 176.6 25.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily EF-hand_7 PF13499.6 CDW57296.1 - 1.5e-11 44.6 4.5 1.5e-11 44.6 4.5 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDW57296.1 - 4.1e-09 35.7 2.0 1e-05 25.0 0.7 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CDW57296.1 - 1.9e-08 33.2 0.9 0.0015 17.9 0.2 3.0 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 CDW57296.1 - 0.00033 20.0 1.7 0.012 15.1 0.1 2.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 CDW57296.1 - 0.003 17.4 0.4 1.7 8.6 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair DUF1577 PF07614.11 CDW57296.1 - 0.13 11.3 5.1 0.22 10.6 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1577) Na_Ca_ex_C PF16494.5 CDW57296.1 - 0.16 12.4 11.0 0.062 13.8 8.0 1.9 1 1 1 2 2 2 0 C-terminal extension of sodium/calcium exchanger domain ALMT PF11744.8 CDW57296.1 - 0.6 8.9 6.4 0.18 10.6 2.8 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter PP_M1 PF03012.14 CDW57297.1 - 0.13 11.8 0.1 0.42 10.1 0.0 1.7 1 1 0 1 1 1 0 Phosphoprotein Podoplanin PF05808.11 CDW57297.1 - 0.3 11.2 2.5 0.58 10.3 2.5 1.4 1 0 0 1 1 1 0 Podoplanin MAPKK1_Int PF08923.10 CDW57298.1 - 3.2e-23 81.8 0.0 3.7e-23 81.6 0.0 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting 7TM_GPCR_Srw PF10324.9 CDW57299.1 - 3.7e-25 88.9 25.7 6.2e-25 88.1 25.7 1.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW57299.1 - 1.2e-15 57.6 15.7 1.4e-15 57.3 14.8 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF1772 PF08592.11 CDW57299.1 - 1.5 9.1 11.6 0.19 12.0 2.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) GoLoco PF02188.17 CDW57301.1 - 1.2e-06 27.8 5.3 1.2e-06 27.8 5.3 1.7 2 0 0 2 2 2 1 GoLoco motif Rap_GAP PF02145.15 CDW57302.1 - 1.2e-63 214.0 0.0 2e-63 213.3 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Mod_r PF07200.13 CDW57302.1 - 0.14 12.3 6.0 0.39 10.8 6.0 1.7 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF4164 PF13747.6 CDW57302.1 - 5 7.5 8.3 11 6.4 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) ZapB PF06005.12 CDW57302.1 - 5.1 7.6 10.4 14 6.2 10.4 1.7 1 0 0 1 1 1 0 Cell division protein ZapB CENP-H PF05837.12 CDW57302.1 - 9.7 6.7 11.5 1.3 9.4 5.7 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) HlyIII PF03006.20 CDW57303.1 - 0.0036 17.0 0.8 0.0052 16.5 0.8 1.2 1 0 0 1 1 1 1 Haemolysin-III related SmpA_OmlA PF04355.13 CDW57303.1 - 0.17 11.7 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 SmpA / OmlA family DoxX_3 PF13781.6 CDW57303.1 - 1.6 9.4 12.9 0.2 12.3 8.9 1.5 2 0 0 2 2 2 0 DoxX-like family IFT43 PF15305.6 CDW57304.1 - 0.051 13.7 0.9 0.074 13.2 0.1 1.7 2 0 0 2 2 2 0 Intraflagellar transport protein 43 Med26 PF08711.11 CDW57305.1 - 4.9e-05 23.3 0.2 0.00011 22.2 0.2 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Fe_bilin_red PF05996.12 CDW57305.1 - 0.07 12.8 2.1 0.12 12.0 2.1 1.3 1 0 0 1 1 1 0 Ferredoxin-dependent bilin reductase Spt20 PF12090.8 CDW57305.1 - 0.12 11.9 11.2 0.24 11.0 11.2 1.4 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 CDW57305.1 - 0.33 9.6 8.6 0.066 11.9 4.8 1.6 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Pex14_N PF04695.13 CDW57305.1 - 2.6 8.7 8.4 1.3 9.6 4.0 2.6 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Complex1_LYR PF05347.15 CDW57306.1 - 5.9e-11 42.3 0.4 5.9e-11 42.3 0.4 1.7 2 1 0 2 2 2 1 Complex 1 protein (LYR family) AlaDh_PNT_C PF01262.21 CDW57307.1 - 7.9e-77 257.4 4.5 1.2e-76 256.8 4.5 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDW57307.1 - 6.5e-43 146.3 0.0 1.6e-42 145.0 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Aminotran_5 PF00266.19 CDW57307.1 - 4.8e-19 68.5 0.0 7.9e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V 2-Hacid_dh_C PF02826.19 CDW57307.1 - 2e-06 27.3 1.0 6.8e-05 22.3 0.2 2.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 CDW57307.1 - 5.5e-06 26.9 0.3 2.1e-05 25.0 0.3 2.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDW57307.1 - 0.00045 19.6 0.3 0.00081 18.7 0.3 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CDW57307.1 - 0.00076 19.6 0.1 0.0036 17.4 0.1 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CDW57307.1 - 0.0045 17.4 0.9 0.017 15.5 0.2 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding GIDA PF01134.22 CDW57307.1 - 0.0054 15.9 0.2 0.01 14.9 0.2 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 CDW57307.1 - 0.02 14.8 0.5 0.02 14.8 0.5 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Cys_Met_Meta_PP PF01053.20 CDW57307.1 - 0.027 13.0 0.0 0.045 12.3 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme UDPG_MGDP_dh_N PF03721.14 CDW57307.1 - 0.09 12.3 0.8 0.21 11.2 0.8 1.7 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HI0933_like PF03486.14 CDW57307.1 - 0.14 10.9 1.8 0.23 10.1 1.8 1.3 1 0 0 1 1 1 0 HI0933-like protein DegT_DnrJ_EryC1 PF01041.17 CDW57307.1 - 0.16 11.3 0.4 0.56 9.5 0.3 1.8 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family FAD_binding_2 PF00890.24 CDW57307.1 - 0.64 9.0 2.9 1.1 8.2 2.9 1.3 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 CDW57307.1 - 4.2 6.6 5.6 6.7 5.9 5.6 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase WYL PF13280.6 CDW57308.1 - 2.8e-34 118.7 0.3 3.6e-34 118.3 0.3 1.1 1 0 0 1 1 1 1 WYL domain HTH_11 PF08279.12 CDW57308.1 - 3.2e-17 62.2 0.6 1.5e-16 60.0 0.0 2.3 2 0 0 2 2 2 1 HTH domain HTH_DeoR PF08220.12 CDW57308.1 - 1.4e-07 31.1 0.0 3e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_20 PF12840.7 CDW57308.1 - 0.00014 21.8 0.1 0.001 19.1 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain Rrf2 PF02082.20 CDW57308.1 - 0.00029 21.1 0.0 0.00063 20.0 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_24 PF13412.6 CDW57308.1 - 0.0012 18.4 1.5 0.0015 18.1 0.0 2.0 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 CDW57308.1 - 0.002 18.0 0.0 0.0047 16.8 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 CDW57308.1 - 0.012 15.4 0.1 0.066 13.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Mga PF05043.13 CDW57308.1 - 0.026 15.1 0.1 0.11 13.1 0.0 2.2 2 0 0 2 2 2 0 Mga helix-turn-helix domain MarR PF01047.22 CDW57308.1 - 0.036 14.0 0.0 0.09 12.7 0.0 1.7 1 0 0 1 1 1 0 MarR family MarR_2 PF12802.7 CDW57308.1 - 0.059 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_22 PF13309.6 CDW57308.1 - 0.07 13.2 0.0 0.43 10.7 0.0 2.4 2 0 0 2 2 2 0 HTH domain HTH_7 PF02796.15 CDW57308.1 - 0.089 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_AsnC-type PF13404.6 CDW57308.1 - 0.093 12.6 0.0 0.093 12.6 0.0 1.8 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain HTH_28 PF13518.6 CDW57308.1 - 0.15 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Pantoate_ligase PF02569.15 CDW57309.1 - 7e-108 359.8 0.4 9.8e-108 359.4 0.4 1.2 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Pantoate_transf PF02548.15 CDW57309.1 - 9.6e-104 346.4 5.6 1.6e-103 345.6 5.6 1.4 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 CDW57309.1 - 8.8e-05 22.1 2.2 0.0001 21.9 0.2 2.2 3 0 0 3 3 3 1 Phosphoenolpyruvate phosphomutase ATP-sulfurylase PF01747.17 CDW57309.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.5 1 1 0 1 1 1 0 ATP-sulfurylase CTP_transf_like PF01467.26 CDW57309.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Cytidylyltransferase-like DUF2520 PF10728.9 CDW57310.1 - 9.5e-33 112.7 0.0 1.7e-32 111.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2520) PDH PF02153.17 CDW57310.1 - 0.00071 18.6 0.0 0.002 17.2 0.0 1.7 1 1 0 1 1 1 1 Prephenate dehydrogenase Rossmann-like PF10727.9 CDW57310.1 - 0.0036 17.2 0.0 0.0068 16.3 0.0 1.4 1 0 0 1 1 1 1 Rossmann-like domain IlvN PF07991.12 CDW57310.1 - 0.0085 15.7 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 CDW57310.1 - 0.057 14.0 0.0 0.17 12.5 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Creatinase_N PF01321.18 CDW57310.1 - 0.067 13.8 0.0 0.34 11.6 0.0 2.3 2 1 0 2 2 2 0 Creatinase/Prolidase N-terminal domain NAD_Gly3P_dh_N PF01210.23 CDW57310.1 - 0.16 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Mga PF05043.13 CDW57311.1 - 3.1e-14 53.3 0.7 3.2e-13 50.1 0.2 2.9 3 1 1 4 4 4 1 Mga helix-turn-helix domain HTH_Mga PF08280.11 CDW57311.1 - 0.00064 19.7 0.0 0.0022 18.0 0.0 1.9 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain Sortase PF04203.13 CDW57312.1 - 1.7e-07 31.1 0.0 4.6e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Sortase domain Peptidase_M16_C PF05193.21 CDW57312.1 - 0.0023 18.0 0.1 0.0059 16.6 0.1 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain Xpo1 PF08389.12 CDW57312.1 - 0.087 12.9 0.6 1.1 9.4 0.0 2.8 3 1 1 4 4 4 0 Exportin 1-like protein SRP-alpha_N PF04086.13 CDW57312.1 - 0.12 12.2 10.1 0.29 11.0 10.1 1.6 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SWI-SNF_Ssr4 PF08549.10 CDW57312.1 - 6.1 5.4 12.3 9.5 4.7 12.3 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Pro_isomerase PF00160.21 CDW57313.1 - 1e-39 136.3 0.0 1.5e-39 135.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cyt_bd_oxida_I PF01654.17 CDW57314.1 - 3.6e-137 457.4 22.3 3.6e-137 457.4 22.3 2.0 2 0 0 2 2 2 1 Cytochrome bd terminal oxidase subunit I ABC_tran PF00005.27 CDW57314.1 - 6e-59 198.5 0.0 5.4e-28 98.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter DAGK_cat PF00781.24 CDW57314.1 - 6.9e-33 112.9 0.0 1.4e-32 112.0 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain ABC_membrane PF00664.23 CDW57314.1 - 2.8e-27 96.1 13.2 2.8e-27 96.1 13.2 2.9 4 0 0 4 4 3 1 ABC transporter transmembrane region Cyt_bd_oxida_II PF02322.15 CDW57314.1 - 4.9e-18 65.5 2.5 4.9e-18 65.5 2.5 4.5 4 1 0 4 4 2 1 Cytochrome bd terminal oxidase subunit II AAA_29 PF13555.6 CDW57314.1 - 1.6e-09 37.4 0.5 0.00011 21.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 CDW57314.1 - 1.9e-08 34.0 0.0 0.027 13.9 0.0 3.7 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDW57314.1 - 4.6e-08 33.2 13.4 0.0039 17.1 0.4 4.5 2 2 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CDW57314.1 - 5.3e-08 32.9 0.1 0.0082 16.2 0.0 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW57314.1 - 7e-08 32.6 0.1 0.013 15.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CDW57314.1 - 1.4e-06 28.8 0.1 0.033 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 CDW57314.1 - 7.2e-05 23.0 4.6 0.11 12.6 0.1 3.5 4 0 0 4 4 3 2 Helicase HerA, central domain AAA_18 PF13238.6 CDW57314.1 - 8.8e-05 23.1 0.0 0.28 11.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CDW57314.1 - 0.00026 21.3 0.1 0.9 9.8 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CDW57314.1 - 0.00069 19.8 0.0 0.71 10.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CDW57314.1 - 0.0013 19.3 3.6 1.4 9.3 1.4 2.9 2 1 0 2 2 2 2 AAA domain AAA_24 PF13479.6 CDW57314.1 - 0.0013 18.5 0.1 2.1 8.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 CDW57314.1 - 0.0027 17.0 0.0 0.18 11.1 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin NAD_kinase PF01513.21 CDW57314.1 - 0.0031 16.8 0.0 0.005 16.1 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase NB-ARC PF00931.22 CDW57314.1 - 0.0032 16.7 0.6 2.1 7.4 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Dynamin_N PF00350.23 CDW57314.1 - 0.0091 16.1 1.1 2.1 8.4 0.2 2.7 2 0 0 2 2 2 1 Dynamin family G-alpha PF00503.20 CDW57314.1 - 0.012 14.8 0.1 3.8 6.6 0.1 2.7 2 1 1 3 3 3 0 G-protein alpha subunit PRK PF00485.18 CDW57314.1 - 0.017 14.8 0.1 6.8 6.4 0.1 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_28 PF13521.6 CDW57314.1 - 0.018 15.3 0.0 10 6.4 0.0 3.0 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CDW57314.1 - 0.021 14.2 0.2 7 5.9 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family MeaB PF03308.16 CDW57314.1 - 0.027 13.4 0.1 0.31 10.0 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 CDW57314.1 - 0.038 14.4 0.0 5.3 7.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.20 CDW57314.1 - 0.046 13.6 0.1 3.8 7.4 0.1 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase Roc PF08477.13 CDW57314.1 - 0.08 13.2 0.1 19 5.5 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 CDW57314.1 - 0.087 12.7 0.0 14 5.6 0.0 2.6 2 0 0 2 2 2 0 NTPase T2SSE PF00437.20 CDW57314.1 - 0.092 11.8 0.0 9.2 5.2 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein PduV-EutP PF10662.9 CDW57314.1 - 0.12 12.1 0.1 17 5.1 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IIGP PF05049.13 CDW57314.1 - 0.12 11.4 0.7 11 4.9 0.1 2.4 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) ATP_bind_1 PF03029.17 CDW57314.1 - 0.14 12.0 0.0 1.8 8.3 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 CDW57314.1 - 0.17 11.9 0.0 30 4.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDW57314.1 - 0.18 11.1 0.0 13 5.0 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CDW57314.1 - 0.4 10.6 3.5 4.4 7.2 0.1 3.1 3 0 0 3 3 3 0 NACHT domain Tmemb_55A PF09788.9 CDW57314.1 - 0.72 8.9 1.6 0.71 8.9 0.0 1.7 2 0 0 2 2 1 0 Transmembrane protein 55A Peptidase_C69 PF03577.15 CDW57315.1 - 4.5e-183 608.7 0.1 5.3e-183 608.5 0.1 1.0 1 0 0 1 1 1 1 Peptidase family C69 Trp_syntA PF00290.20 CDW57316.1 - 4.9e-68 228.8 0.1 5.9e-68 228.5 0.1 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain BtpA PF03437.15 CDW57316.1 - 0.00023 20.7 0.1 0.00033 20.2 0.1 1.2 1 0 0 1 1 1 1 BtpA family His_biosynth PF00977.21 CDW57316.1 - 0.0026 17.3 0.0 0.0043 16.5 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein PALP PF00291.25 CDW57317.1 - 2.6e-47 161.7 0.5 3.1e-47 161.4 0.5 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DDE_Tnp_1_3 PF13612.6 CDW57317.1 - 0.097 12.7 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Transposase DDE domain IGPS PF00218.21 CDW57318.1 - 4.8e-78 261.8 1.9 6.9e-78 261.3 1.9 1.2 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 CDW57318.1 - 8.2e-41 139.9 0.0 1.8e-40 138.8 0.0 1.6 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase QRPTase_C PF01729.19 CDW57318.1 - 8.7e-05 22.4 0.2 0.0011 18.7 0.1 2.6 2 1 1 3 3 3 1 Quinolinate phosphoribosyl transferase, C-terminal domain RibD_C PF01872.17 CDW57318.1 - 0.00013 21.8 0.0 0.00025 20.9 0.0 1.4 1 0 0 1 1 1 1 RibD C-terminal domain Chorismate_bind PF00425.18 CDW57319.1 - 1.4e-93 313.2 0.1 2e-93 312.7 0.1 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Glycos_transf_3 PF00591.21 CDW57319.1 - 1.3e-85 287.0 0.2 2.3e-85 286.3 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain GATase PF00117.28 CDW57319.1 - 5e-25 88.4 0.5 1.3e-21 77.2 0.4 2.5 1 1 1 2 2 2 2 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 CDW57319.1 - 2.4e-16 60.2 0.6 5.9e-16 59.0 0.2 1.9 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Glycos_trans_3N PF02885.17 CDW57319.1 - 2.4e-11 43.3 0.2 7e-11 41.8 0.2 1.8 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Peptidase_C26 PF07722.13 CDW57319.1 - 0.0011 18.8 0.8 0.037 13.8 0.0 2.4 1 1 1 2 2 2 2 Peptidase C26 Fusion_gly PF00523.18 CDW57319.1 - 0.24 9.6 0.1 0.39 8.9 0.1 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 TM1586_NiRdase PF14512.6 CDW57321.1 - 6e-35 120.8 0.0 7e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Putative TM nitroreductase Nitroreductase PF00881.24 CDW57321.1 - 3.1e-05 24.1 0.0 0.047 13.7 0.0 2.4 2 0 0 2 2 2 2 Nitroreductase family OsmC PF02566.19 CDW57322.1 - 3.6e-19 69.1 0.0 5e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 OsmC-like protein Acetyltransf_1 PF00583.25 CDW57323.1 - 3.7e-08 33.6 0.1 6.9e-08 32.7 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW57323.1 - 0.00073 19.5 0.1 0.0011 18.9 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CRISPR_Cas9_WED PF18061.1 CDW57323.1 - 0.0021 18.2 0.0 0.0046 17.0 0.0 1.6 1 1 0 1 1 1 1 CRISPR-Cas9 WED domain Acetyltransf_7 PF13508.7 CDW57323.1 - 0.0045 17.4 0.1 0.0093 16.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDW57323.1 - 0.0054 16.9 0.1 0.011 15.9 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDW57323.1 - 0.0068 16.5 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pfk_N PF18468.1 CDW57323.1 - 0.088 13.2 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Phosphofructokinase N-terminal domain yeast Mpv17_PMP22 PF04117.12 CDW57324.1 - 0.00016 21.8 2.9 0.00022 21.4 2.0 1.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family ADH_zinc_N PF00107.26 CDW57325.1 - 1.6e-25 89.6 0.0 2.6e-25 88.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW57325.1 - 2.2e-21 75.8 0.4 3.9e-21 75.0 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CDW57325.1 - 3.6e-05 24.8 0.0 6.5e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CDW57325.1 - 0.0002 20.9 0.0 0.0003 20.3 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CDW57325.1 - 0.0018 17.6 0.1 0.0038 16.5 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CDW57325.1 - 0.014 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 CDW57325.1 - 0.027 14.7 0.0 0.058 13.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_12 PF08242.12 CDW57325.1 - 0.06 14.1 0.3 0.36 11.6 0.3 2.2 1 1 0 1 1 1 0 Methyltransferase domain Asp_decarbox PF02261.16 CDW57325.1 - 0.079 12.9 0.1 0.67 9.9 0.0 2.3 2 0 0 2 2 2 0 Aspartate decarboxylase Acetate_kinase PF00871.17 CDW57326.1 - 4e-40 137.7 0.6 8.5e-40 136.6 0.6 1.5 1 0 0 1 1 1 1 Acetokinase family PTA_PTB PF01515.19 CDW57326.1 - 2e-31 109.5 2.7 4.3e-31 108.4 0.9 2.1 1 1 1 2 2 2 1 Phosphate acetyl/butaryl transferase Aldedh PF00171.22 CDW57326.1 - 8.3e-16 57.5 0.2 1.6e-10 40.1 0.0 2.4 3 0 0 3 3 3 2 Aldehyde dehydrogenase family NLPC_P60 PF00877.19 CDW57327.1 - 7e-23 80.7 0.0 1.7e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 NlpC/P60 family Glucosaminidase PF01832.20 CDW57327.1 - 1.3e-22 80.1 0.7 2.9e-22 79.0 0.7 1.7 1 0 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Peptidase_C92 PF05708.12 CDW57327.1 - 0.00017 21.7 0.0 0.011 15.9 0.0 2.6 2 0 0 2 2 2 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Amidase_5 PF05382.13 CDW57327.1 - 0.00023 21.1 0.1 0.00072 19.5 0.1 1.8 1 0 0 1 1 1 1 Bacteriophage peptidoglycan hydrolase DUF1175 PF06672.11 CDW57327.1 - 0.066 12.9 0.0 1.1 8.8 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1175) FCH PF00611.23 CDW57327.1 - 0.12 12.7 0.4 0.33 11.3 0.4 1.7 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain Cation_efflux PF01545.21 CDW57328.1 - 1.3e-39 136.0 7.0 1.6e-39 135.7 7.0 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDW57328.1 - 8.5e-20 70.7 0.7 1.5e-16 60.3 0.1 2.3 2 0 0 2 2 2 2 Dimerisation domain of Zinc Transporter EI24 PF07264.11 CDW57328.1 - 0.037 14.3 3.5 0.055 13.7 3.5 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) FtsX PF02687.21 CDW57329.1 - 0.0014 19.1 18.9 0.0037 17.7 7.6 4.9 5 1 0 5 5 5 2 FtsX-like permease family Cadherin_C_2 PF16492.5 CDW57329.1 - 0.18 12.6 0.0 0.18 12.6 0.0 3.8 3 2 0 3 3 3 0 Cadherin cytoplasmic C-terminal PepSY_TM PF03929.16 CDW57329.1 - 0.88 9.2 0.0 0.88 9.2 0.0 2.7 3 0 0 3 3 3 0 PepSY-associated TM region OppC_N PF12911.7 CDW57329.1 - 4.8 7.2 0.0 4.8 7.2 0.0 5.6 6 0 0 6 6 6 0 N-terminal TM domain of oligopeptide transport permease C ABC_tran PF00005.27 CDW57330.1 - 1.2e-33 116.6 0.0 1.7e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW57330.1 - 8.7e-06 25.8 1.0 0.014 15.2 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW57330.1 - 3e-05 23.5 0.2 0.0024 17.3 0.2 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDW57330.1 - 0.00011 21.9 0.3 0.00023 20.8 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDW57330.1 - 0.00026 20.9 0.1 0.00047 20.1 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDW57330.1 - 0.00053 20.4 0.1 0.0014 19.0 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 CDW57330.1 - 0.0019 18.1 0.0 2 8.3 0.0 2.2 2 0 0 2 2 2 2 NTPase NACHT PF05729.12 CDW57330.1 - 0.0027 17.7 0.1 0.022 14.7 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 CDW57330.1 - 0.0042 16.8 0.0 0.2 11.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDW57330.1 - 0.0043 17.3 0.2 0.016 15.5 0.2 2.1 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDW57330.1 - 0.007 16.9 0.0 0.017 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDW57330.1 - 0.0079 16.3 0.1 0.02 15.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF87 PF01935.17 CDW57330.1 - 0.0099 16.0 0.6 0.012 15.7 0.6 1.6 1 1 0 1 1 1 1 Helicase HerA, central domain AAA_15 PF13175.6 CDW57330.1 - 0.011 15.5 0.2 0.099 12.3 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain ATPase PF06745.13 CDW57330.1 - 0.082 12.2 0.1 9.5 5.5 0.0 2.6 3 0 0 3 3 3 0 KaiC IstB_IS21 PF01695.17 CDW57330.1 - 0.085 12.6 0.1 1.7 8.3 0.0 2.3 2 1 0 2 2 2 0 IstB-like ATP binding protein FtsK_SpoIIIE PF01580.18 CDW57330.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 CDW57330.1 - 0.13 12.3 0.4 0.49 10.4 0.2 1.9 2 0 0 2 2 2 0 Dynamin family AAA_18 PF13238.6 CDW57330.1 - 0.16 12.5 0.0 0.51 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF1980 PF09323.10 CDW57331.1 - 4.2e-61 206.0 3.2 7.9e-61 205.1 3.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1980) HATPase_c PF02518.26 CDW57331.1 - 5.8e-17 62.2 0.0 1.4e-16 60.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDW57331.1 - 6.1e-07 29.6 0.4 2.7e-05 24.3 0.1 2.6 1 1 1 2 2 2 1 Response regulator receiver domain HATPase_c_3 PF13589.6 CDW57331.1 - 0.01 15.7 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CDW57331.1 - 0.022 14.7 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain DUF4839 PF16127.5 CDW57331.1 - 0.024 14.7 0.3 0.14 12.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4839) SH2_2 PF14633.6 CDW57332.1 - 3.5e-77 258.7 0.8 9.4e-77 257.3 0.2 2.1 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 CDW57332.1 - 3e-38 130.3 0.0 6.7e-38 129.2 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 CDW57332.1 - 1.3e-28 99.7 0.1 1e-27 96.8 0.1 2.2 1 1 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 CDW57332.1 - 7.9e-20 71.4 1.5 2.2e-19 70.0 0.3 2.3 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 S1 PF00575.23 CDW57332.1 - 1.1e-09 38.5 0.0 4.5e-09 36.5 0.0 2.1 2 0 0 2 2 2 1 S1 RNA binding domain Tex_N PF09371.10 CDW57332.1 - 7.2e-08 32.3 0.1 0.0028 17.3 0.0 2.8 2 0 0 2 2 2 2 Tex-like protein N-terminal domain HHH_3 PF12836.7 CDW57332.1 - 7.7e-08 32.5 0.0 3.9e-07 30.2 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif SH2 PF00017.24 CDW57332.1 - 1.8e-07 31.1 0.0 5.5e-05 23.2 0.0 2.9 2 0 0 2 2 2 1 SH2 domain Tex_YqgF PF16921.5 CDW57332.1 - 2e-07 31.5 0.3 7e-07 29.7 0.2 2.0 2 0 0 2 2 2 1 Tex protein YqgF-like domain HHH_9 PF17674.1 CDW57332.1 - 4.8e-05 24.2 0.1 0.00018 22.4 0.1 2.1 1 0 0 1 1 1 1 HHH domain MMR_HSR1 PF01926.23 CDW57333.1 - 1.2e-21 76.9 0.2 2e-21 76.2 0.0 1.5 2 0 0 2 2 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW57333.1 - 2.2e-15 56.5 0.1 2e-14 53.4 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CDW57333.1 - 2.6e-06 26.9 0.1 5e-06 26.0 0.1 1.5 1 1 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 CDW57333.1 - 6.5e-06 26.3 0.1 3e-05 24.1 0.1 1.8 1 1 0 1 1 1 1 Dynamin family Ras PF00071.22 CDW57333.1 - 7.2e-06 25.7 0.0 1.1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 CDW57333.1 - 1.7e-05 24.8 0.0 0.0037 17.2 0.0 2.6 2 2 0 2 2 2 1 RsgA GTPase MnmE_helical PF12631.7 CDW57333.1 - 0.00028 21.1 0.0 0.00039 20.6 0.0 1.1 1 0 0 1 1 1 1 MnmE helical domain Arf PF00025.21 CDW57333.1 - 0.0016 17.9 0.1 0.023 14.1 0.1 2.2 1 1 0 1 1 1 1 ADP-ribosylation factor family ABC_tran PF00005.27 CDW57333.1 - 0.0022 18.5 0.0 0.0032 18.0 0.0 1.5 1 1 0 1 1 1 1 ABC transporter Roc PF08477.13 CDW57333.1 - 0.003 17.8 0.0 0.019 15.2 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 CDW57333.1 - 0.0063 15.6 0.3 0.21 10.7 0.0 2.1 1 1 0 2 2 2 1 MCM P-loop domain AAA_18 PF13238.6 CDW57333.1 - 0.036 14.6 0.0 0.053 14.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW57333.1 - 0.093 12.4 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain 7TM_GPCR_Srw PF10324.9 CDW57334.1 - 2.3e-13 50.1 30.5 3.4e-13 49.6 30.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW57334.1 - 4.9e-10 39.2 23.9 1.3e-09 37.8 23.9 1.7 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DsbD PF02683.15 CDW57334.1 - 0.035 14.0 8.1 0.37 10.6 8.1 2.2 1 1 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region Phage_Coat_Gp8 PF05371.12 CDW57334.1 - 0.23 11.3 0.8 0.47 10.3 0.8 1.4 1 0 0 1 1 1 0 Phage major coat protein, Gp8 COX7C PF02935.16 CDW57334.1 - 0.75 10.1 0.1 0.75 10.1 0.1 3.4 3 1 1 4 4 4 0 Cytochrome c oxidase subunit VIIc PTB PF08416.13 CDW57336.1 - 2e-31 108.9 0.0 3.8e-31 108.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH2 PF00017.24 CDW57336.1 - 1.8e-11 44.0 0.0 5e-11 42.6 0.0 1.8 1 0 0 1 1 1 1 SH2 domain PID PF00640.23 CDW57336.1 - 0.053 13.6 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) MRP-S33 PF08293.11 CDW57337.1 - 5.1e-14 52.3 0.5 7.3e-14 51.8 0.5 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Hydrolase_6 PF13344.6 CDW57338.1 - 1.7e-16 60.2 0.1 1.6e-15 57.0 0.0 2.5 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW57338.1 - 2.5e-16 59.5 0.0 4.1e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CDW57338.1 - 2.1e-09 38.0 0.0 3.6e-09 37.2 0.0 1.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDW57338.1 - 1.4e-05 25.2 0.0 2.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 CDW57338.1 - 0.091 12.4 0.0 0.34 10.5 0.0 1.9 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase RNase_T PF00929.24 CDW57339.1 - 3.2e-23 83.1 0.1 4.1e-23 82.7 0.1 1.1 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 CDW57339.1 - 0.058 13.4 0.0 0.086 12.8 0.0 1.3 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like MM_CoA_mutase PF01642.22 CDW57340.1 - 6.7e-238 790.4 0.2 8.1e-238 790.1 0.2 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 CDW57340.1 - 4.2e-11 42.9 0.1 1.1e-10 41.6 0.1 1.7 1 0 0 1 1 1 1 B12 binding domain RNase_PH PF01138.21 CDW57341.1 - 1.1e-30 106.8 0.2 1.6e-30 106.3 0.2 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDW57341.1 - 4.9e-08 32.9 0.0 1.2e-07 31.7 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 RabGAP-TBC PF00566.18 CDW57343.1 - 2e-21 76.6 4.0 5.2e-19 68.8 0.7 2.6 1 1 1 2 2 2 2 Rab-GTPase-TBC domain Pkinase PF00069.25 CDW57343.1 - 1.9e-12 47.2 0.0 4e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Rhodanese PF00581.20 CDW57343.1 - 1.3e-05 25.7 0.0 2.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase_Tyr PF07714.17 CDW57343.1 - 0.00015 21.1 0.0 0.12 11.6 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase MoaE PF02391.17 CDW57344.1 - 2.3e-28 98.8 0.0 7.2e-28 97.1 0.0 1.8 1 1 0 1 1 1 1 MoaE protein PRK PF00485.18 CDW57344.1 - 0.00018 21.3 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CDW57344.1 - 0.0002 21.9 0.0 0.00049 20.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CDW57344.1 - 0.0013 18.6 0.1 0.0048 16.8 0.0 1.9 2 0 0 2 2 2 1 Adenylylsulphate kinase DnaB PF00772.21 CDW57344.1 - 0.16 12.1 0.1 0.66 10.1 0.1 2.0 2 0 0 2 2 2 0 DnaB-like helicase N terminal domain CPT PF07931.12 CDW57344.1 - 0.18 11.6 0.1 1 9.2 0.0 2.0 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Ssl1 PF04056.14 CDW57345.1 - 5.2e-47 160.2 0.3 9.8e-46 156.0 0.3 2.6 1 1 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 CDW57345.1 - 2.6e-13 50.0 23.0 2.7e-11 43.5 14.1 3.0 2 1 0 2 2 2 2 TFIIH C1-like domain VWA_2 PF13519.6 CDW57345.1 - 7.3e-06 26.6 0.0 6.1e-05 23.6 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain C1_2 PF03107.16 CDW57345.1 - 0.038 14.3 3.8 0.038 14.3 3.8 3.3 2 1 1 3 3 3 0 C1 domain IBR PF01485.21 CDW57345.1 - 0.24 11.6 16.1 45 4.4 1.6 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DZR PF12773.7 CDW57345.1 - 1.6 8.9 17.4 8.3e+02 0.1 17.4 2.7 1 1 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 CDW57345.1 - 5.5 7.2 15.4 36 4.6 5.7 2.5 1 1 1 2 2 2 0 FYVE zinc finger SH3_9 PF14604.6 CDW57346.1 - 2.4e-15 56.1 0.1 5.5e-15 54.9 0.1 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 CDW57346.1 - 6.5e-12 44.9 0.2 1.1e-11 44.2 0.2 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CDW57346.1 - 1.2e-07 31.3 0.0 2.1e-07 30.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain adh_short PF00106.25 CDW57347.1 - 7.3e-22 77.8 0.0 2.2e-19 69.7 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDW57347.1 - 4.2e-16 59.2 0.0 5.5e-15 55.6 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW57347.1 - 1.4e-05 25.1 0.0 2.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CDW57347.1 - 0.00015 21.3 0.0 0.00033 20.2 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDW57347.1 - 0.0038 16.7 0.0 0.0094 15.4 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CDW57347.1 - 0.027 14.4 0.0 0.077 12.9 0.0 1.8 1 1 0 1 1 1 0 NAD(P)H-binding CMAS PF02353.20 CDW57347.1 - 0.058 12.7 0.0 0.086 12.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase ig PF00047.25 CDW57348.1 - 0.013 15.7 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 CDW57348.1 - 0.14 12.2 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin I-set domain Methyltrn_RNA_3 PF02598.17 CDW57349.1 - 6.1e-95 318.0 0.0 7.1e-95 317.8 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase SpoU_methylase PF00588.19 CDW57349.1 - 0.041 14.1 0.0 2 8.6 0.0 2.3 2 0 0 2 2 2 0 SpoU rRNA Methylase family Tyrosinase PF00264.20 CDW57350.1 - 2.3e-07 31.4 0.2 1.2e-06 29.0 0.0 2.1 3 0 0 3 3 3 1 Common central domain of tyrosinase Laminin_EGF PF00053.24 CDW57350.1 - 0.0018 18.4 1.8 0.0018 18.4 1.8 2.3 2 0 0 2 2 2 1 Laminin EGF domain SNF2_N PF00176.23 CDW57351.1 - 8.9e-68 228.6 0.3 3e-67 226.8 0.3 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 CDW57351.1 - 2.8e-41 140.1 2.5 1.1e-40 138.2 2.5 2.2 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 CDW57351.1 - 1.4e-26 93.4 1.9 1.4e-26 93.4 1.9 2.9 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 CDW57351.1 - 4e-19 69.0 0.0 1.6e-18 67.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW57351.1 - 1.9e-11 44.2 0.0 7.9e-11 42.2 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDW57351.1 - 1e-05 25.4 0.0 3.8e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase DBINO PF13892.6 CDW57351.1 - 8.7e-05 22.9 0.1 8.7e-05 22.9 0.1 4.1 4 1 0 4 4 4 1 DNA-binding domain SWI2_SNF2 PF18766.1 CDW57351.1 - 0.00047 19.9 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_14 PF13173.6 CDW57351.1 - 0.089 12.8 0.1 0.36 10.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.31 CDW57351.1 - 0.13 12.4 0.0 0.13 12.4 0.0 3.1 3 0 0 3 3 3 0 Myb-like DNA-binding domain SIR2 PF02146.17 CDW57352.1 - 4.4e-54 183.1 0.0 6e-54 182.6 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CDW57352.1 - 0.0015 18.3 0.1 0.5 10.1 0.1 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Fer2 PF00111.27 CDW57352.1 - 0.19 11.7 1.5 0.3 11.1 0.6 1.7 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain GalKase_gal_bdg PF10509.9 CDW57353.1 - 9.9e-18 63.4 0.7 2.6e-16 58.9 0.7 2.4 1 1 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 CDW57353.1 - 4.6e-11 42.9 0.0 1.4e-10 41.3 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 CDW57353.1 - 3.1e-10 40.2 1.7 6.6e-10 39.1 1.7 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain Methyltr_RsmB-F PF01189.17 CDW57354.1 - 5.3e-34 117.6 0.0 7.2e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 CDW57354.1 - 0.00014 22.1 0.0 0.00021 21.4 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 CDW57354.1 - 0.0047 17.6 0.0 0.029 15.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CDW57354.1 - 0.0048 16.7 0.0 0.0085 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 CDW57354.1 - 0.023 14.0 0.0 0.039 13.3 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 CDW57354.1 - 0.059 13.2 0.0 0.16 11.8 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Fibrillarin PF01269.17 CDW57354.1 - 0.097 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Fibrillarin Pan3_PK PF18101.1 CDW57355.1 - 6e-22 78.1 0.1 3.4e-13 49.7 0.0 2.2 2 0 0 2 2 2 2 Pan3 Pseudokinase domain AP_endonuc_2 PF01261.24 CDW57356.1 - 2.3e-26 92.5 0.0 2.2e-25 89.3 0.0 2.3 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel CNV-Replicase_N PF16688.5 CDW57356.1 - 0.041 14.2 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 Replicase polyprotein N-term from Coronavirus nsp1 LSM PF01423.22 CDW57357.1 - 4e-09 36.0 0.0 5.5e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDW57357.1 - 0.091 12.9 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain EGF PF00008.27 CDW57359.1 - 6.9e-05 23.1 0.8 0.00012 22.3 0.8 1.4 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 CDW57359.1 - 0.00029 21.4 1.2 0.00059 20.4 1.2 1.6 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.13 CDW57359.1 - 0.0031 17.8 1.4 0.0046 17.3 1.4 1.3 1 0 0 1 1 1 1 EGF-like domain EGF_CA PF07645.15 CDW57359.1 - 0.014 15.6 0.6 0.022 15.0 0.6 1.3 1 0 0 1 1 1 0 Calcium-binding EGF domain Col_cuticle_N PF01484.17 CDW57359.1 - 0.088 12.9 1.8 0.13 12.4 1.8 1.3 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain EGF_3 PF12947.7 CDW57359.1 - 0.2 11.9 2.4 0.33 11.2 2.4 1.3 1 0 0 1 1 1 0 EGF domain ATG101 PF07855.12 CDW57360.1 - 1.9e-36 125.4 0.3 2.3e-36 125.1 0.3 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 zf-RING_5 PF14634.6 CDW57361.1 - 0.0011 18.9 2.0 0.0025 17.8 2.0 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-ribbon_3 PF13248.6 CDW57361.1 - 0.073 12.5 1.3 2.2 7.8 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Prok-RING_1 PF14446.6 CDW57361.1 - 0.15 12.0 0.4 3.4 7.7 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 OrfB_Zn_ribbon PF07282.11 CDW57361.1 - 0.16 11.9 0.7 4 7.5 0.0 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Zn_ribbon_17 PF17120.5 CDW57361.1 - 0.19 11.4 1.6 0.23 11.1 0.3 1.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DiS_P_DiS PF06750.13 CDW57361.1 - 0.27 11.4 2.1 3.5 7.8 0.4 2.5 1 1 1 2 2 2 0 Bacterial Peptidase A24 N-terminal domain zf-rbx1 PF12678.7 CDW57361.1 - 0.56 10.5 4.8 0.1 12.9 0.7 1.8 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CDW57361.1 - 0.97 9.2 4.8 2.1 8.1 4.8 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_2 PF13639.6 CDW57361.1 - 2.5 8.5 8.3 25 5.3 8.3 2.3 1 1 0 1 1 1 0 Ring finger domain zf-C3H2C3 PF17122.5 CDW57361.1 - 6.1 7.0 8.5 0.27 11.3 2.0 2.1 2 0 0 2 2 2 0 Zinc-finger WD40 PF00400.32 CDW57362.1 - 9.7e-66 216.1 21.6 1.2e-10 41.8 0.1 7.7 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57362.1 - 1.6e-20 73.2 0.6 4.7e-05 23.6 0.0 5.5 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW57362.1 - 7.2e-12 44.7 7.6 0.0018 17.0 0.0 6.5 2 2 5 7 7 7 4 Nucleoporin Nup120/160 LisH PF08513.11 CDW57362.1 - 1.1e-08 34.7 0.1 2e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 LisH Nucleoporin_N PF08801.11 CDW57362.1 - 1.6e-07 30.4 0.0 0.023 13.4 0.0 3.7 2 1 2 4 4 4 3 Nup133 N terminal like Ge1_WD40 PF16529.5 CDW57362.1 - 6e-05 22.2 8.4 0.42 9.5 0.1 4.8 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein LAGLIDADG_3 PF14528.6 CDW57363.1 - 0.11 12.8 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 LAGLIDADG-like domain DUF2069 PF09842.9 CDW57363.1 - 0.21 11.8 5.3 1.2 9.4 1.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2069) Pkinase PF00069.25 CDW57365.1 - 8e-26 91.0 0.0 9.2e-26 90.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57365.1 - 6.6e-12 45.3 0.0 7.8e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW57365.1 - 3.2e-05 23.4 0.0 4.9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW57365.1 - 0.00011 21.1 0.0 0.00015 20.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW57365.1 - 0.0014 18.6 0.0 0.014 15.4 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDW57365.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Hydrolase PF00702.26 CDW57367.1 - 1.7e-46 159.2 0.6 7.4e-46 157.1 0.2 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDW57367.1 - 1.2e-43 147.3 3.5 2.1e-12 47.3 0.0 5.0 4 0 0 4 4 4 4 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 CDW57367.1 - 7.3e-42 142.9 7.0 1.3e-41 142.1 4.1 2.8 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CDW57367.1 - 0.0044 16.8 3.1 0.013 15.2 1.1 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Fer2_BFD PF04324.15 CDW57367.1 - 5.2 7.5 6.8 93 3.5 0.1 4.6 4 0 0 4 4 4 0 BFD-like [2Fe-2S] binding domain zf-primase PF09329.11 CDW57367.1 - 9.4 6.1 9.6 7.6 6.4 0.2 3.4 4 0 0 4 4 4 0 Primase zinc finger Sulfotransfer_1 PF00685.27 CDW57368.1 - 1.2e-05 24.9 0.0 1.4e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDW57368.1 - 0.0066 16.8 0.0 0.018 15.4 0.0 1.7 2 0 0 2 2 2 1 Sulfotransferase family TUDOR PF00567.24 CDW57369.1 - 9.7e-13 48.2 0.0 1.5e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.29 CDW57369.1 - 9.4e-11 41.4 0.0 1.5e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 KH domain Mt_ATP-synt_D PF05873.12 CDW57370.1 - 6.8e-16 58.5 0.1 7.1e-16 58.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DUF4250 PF14056.6 CDW57370.1 - 0.04 13.9 0.0 0.058 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) RabGAP-TBC PF00566.18 CDW57371.1 - 1.8e-36 125.8 0.3 3.1e-36 125.1 0.3 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 CDW57371.1 - 0.00028 20.4 0.0 0.00071 19.1 0.0 1.7 1 0 0 1 1 1 1 Rab-binding domain (RBD) Pro_isomerase PF00160.21 CDW57372.1 - 6.2e-50 169.5 0.2 8.2e-50 169.2 0.2 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Exo_endo_phos PF03372.23 CDW57373.1 - 0.00061 19.4 0.0 0.0022 17.6 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Presenilin PF01080.17 CDW57374.1 - 5.4e-245 812.4 37.9 1.8e-127 425.4 7.5 3.1 2 1 1 3 3 3 3 Presenilin EMP24_GP25L PF01105.24 CDW57375.1 - 1.4e-51 175.0 0.2 1.6e-51 174.8 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MHC2-interact PF09307.10 CDW57375.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 CLIP, MHC2 interacting TSC22 PF01166.18 CDW57375.1 - 0.02 15.2 1.8 0.034 14.4 1.8 1.3 1 0 0 1 1 1 0 TSC-22/dip/bun family FtsX_ECD PF18075.1 CDW57375.1 - 0.071 13.7 0.3 0.18 12.4 0.1 1.8 2 0 0 2 2 2 0 FtsX extracellular domain DUF1741 PF08427.10 CDW57376.1 - 9.5e-58 195.6 0.1 2.2e-57 194.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) WD40 PF00400.32 CDW57377.1 - 4.9e-35 119.0 3.3 5.7e-06 27.0 0.0 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat CSTF1_dimer PF16699.5 CDW57377.1 - 9.6e-21 73.3 0.2 1.6e-20 72.6 0.2 1.3 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.7 CDW57377.1 - 1.4e-13 50.9 0.0 0.00068 19.9 0.0 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CDW57377.1 - 4.7e-05 22.5 2.1 0.094 11.7 0.2 3.2 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CDW57377.1 - 0.00028 19.6 0.0 0.00088 17.9 0.0 1.8 2 1 0 2 2 2 1 Cytochrome D1 heme domain Nup160 PF11715.8 CDW57377.1 - 0.034 12.8 0.1 0.21 10.2 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Polysacc_synt_4 PF04669.13 CDW57378.1 - 2.3e-07 30.5 0.0 4.9e-05 23.0 0.0 2.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis PDZ PF00595.24 CDW57380.1 - 8.5e-29 99.7 0.8 4.6e-13 49.3 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 CDW57380.1 - 5.5e-15 55.0 0.3 5.7e-08 32.5 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 CDW57380.1 - 4e-11 43.1 0.4 0.00019 21.7 0.1 2.4 2 0 0 2 2 2 2 PDZ domain MNSV_P7B PF06692.11 CDW57380.1 - 0.052 13.5 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein DnaJ PF00226.31 CDW57381.1 - 3.5e-27 94.3 1.3 9.5e-27 92.9 1.3 1.8 1 0 0 1 1 1 1 DnaJ domain HTH_Tnp_IS630 PF01710.16 CDW57381.1 - 0.0012 18.8 0.0 0.004 17.2 0.0 1.9 1 0 0 1 1 1 1 Transposase HTH_40 PF14493.6 CDW57381.1 - 0.051 14.0 0.1 0.59 10.6 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain DUF148 PF02520.17 CDW57381.1 - 0.12 12.5 2.0 15 5.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 HTH_48 PF17906.1 CDW57381.1 - 0.13 12.4 0.0 0.47 10.6 0.0 2.0 1 0 0 1 1 1 0 HTH domain in Mos1 transposase DUF2524 PF10732.9 CDW57381.1 - 0.69 10.3 4.7 0.89 9.9 2.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2524) CAS_C PF12026.8 CDW57382.1 - 2e-35 122.8 0.7 1.2e-34 120.3 0.1 2.1 2 0 0 2 2 2 1 Crk-Associated Substrate C-terminal domain pPIWI_RE_Y PF18156.1 CDW57382.1 - 0.05 14.0 0.1 0.095 13.1 0.1 1.4 1 0 0 1 1 1 0 pPIWI_RE three-gene island domain Y Mlh1_C PF16413.5 CDW57384.1 - 1.1e-70 238.2 0.2 1.1e-70 238.2 0.2 1.5 2 0 0 2 2 2 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 CDW57384.1 - 2.9e-26 91.5 0.0 4.6e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Actin PF00022.19 CDW57385.1 - 7.3e-105 350.9 0.0 1.4e-103 346.6 0.0 2.0 1 1 0 1 1 1 1 Actin Peptidase_M13_N PF05649.13 CDW57386.1 - 1.3e-48 166.6 0.5 1.6e-48 166.3 0.5 1.0 1 0 0 1 1 1 1 Peptidase family M13 Flexi_CP_N PF08358.10 CDW57386.1 - 0.026 14.5 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 Carlavirus coat NOG1_N PF17835.1 CDW57387.1 - 1.8e-50 171.1 1.7 1.8e-50 171.1 1.7 2.6 3 0 0 3 3 3 1 NOG1 N-terminal helical domain Ank_2 PF12796.7 CDW57387.1 - 2.1e-28 98.7 3.3 1.2e-14 54.6 0.1 3.3 3 0 0 3 3 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW57387.1 - 1.8e-19 69.9 4.2 3e-06 27.7 0.0 6.2 3 2 4 7 7 7 6 Ankyrin repeats (many copies) NOGCT PF08155.11 CDW57387.1 - 9.3e-19 67.2 2.1 2.2e-18 66.0 2.1 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 CDW57387.1 - 8e-18 64.6 0.0 2.7e-17 62.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ank_5 PF13857.6 CDW57387.1 - 2.5e-17 62.7 1.0 2.3e-07 30.9 0.0 4.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CDW57387.1 - 9e-15 54.4 0.0 0.0055 17.1 0.0 4.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 CDW57387.1 - 1.9e-14 52.4 0.0 0.00018 21.7 0.0 6.5 6 0 0 6 6 6 2 Ankyrin repeat NOG1 PF06858.14 CDW57387.1 - 5.3e-13 48.5 1.2 2.2e-11 43.3 1.2 2.6 1 1 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) FeoB_N PF02421.18 CDW57387.1 - 3.3e-11 43.0 0.0 7e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDW57387.1 - 0.00056 19.9 0.0 0.048 13.6 0.0 3.1 2 1 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 CDW57387.1 - 0.0068 15.9 0.0 0.016 14.6 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 CDW57387.1 - 0.0076 16.5 0.0 0.8 10.0 0.0 3.2 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 CDW57387.1 - 0.018 15.1 0.1 1.8 8.6 0.0 2.8 1 1 1 2 2 2 0 Dynamin family Dpy-30 PF05186.13 CDW57387.1 - 0.02 14.6 0.0 0.059 13.1 0.0 1.8 1 0 0 1 1 1 0 Dpy-30 motif GATase_7 PF13537.6 CDW57387.1 - 0.024 14.6 0.0 4 7.4 0.0 2.8 2 0 0 2 2 2 0 Glutamine amidotransferase domain AAA_16 PF13191.6 CDW57387.1 - 0.024 15.0 0.0 0.23 11.8 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain DUF1843 PF08898.10 CDW57387.1 - 0.038 14.5 3.2 0.69 10.5 0.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF1843) AIG1 PF04548.16 CDW57387.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 AIG1 family dsrm PF00035.26 CDW57388.1 - 2.5e-22 79.3 0.1 1.4e-08 35.3 0.0 3.4 3 0 0 3 3 3 3 Double-stranded RNA binding motif LPP20 PF02169.16 CDW57388.1 - 9.8e-06 25.8 3.3 0.048 14.0 0.0 2.4 2 0 0 2 2 2 2 LPP20 lipoprotein Dicer_dimer PF03368.14 CDW57388.1 - 0.0012 19.0 0.2 0.035 14.3 0.1 2.9 3 0 0 3 3 3 1 Dicer dimerisation domain DND1_DSRM PF14709.7 CDW57388.1 - 0.028 14.7 4.8 14 6.1 0.0 4.4 4 1 0 4 4 4 0 double strand RNA binding domain from DEAD END PROTEIN 1 SNF PF00209.18 CDW57389.1 - 6.8e-165 549.7 40.4 1.2e-163 545.6 40.4 2.1 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family Glyco_hydro_45 PF02015.16 CDW57389.1 - 0.093 12.6 1.6 0.18 11.7 1.6 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 45 Trypsin PF00089.26 CDW57390.1 - 2.9e-59 200.6 0.5 3.6e-59 200.3 0.5 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW57390.1 - 5e-08 34.0 0.3 9.7e-08 33.0 0.3 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW57390.1 - 2.6e-05 24.6 0.0 4.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) tRNA_SAD PF07973.14 CDW57390.1 - 0.0037 17.3 0.4 0.0077 16.3 0.4 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Mito_carr PF00153.27 CDW57392.1 - 1.5e-68 226.8 0.2 2.9e-23 81.6 0.0 3.3 2 1 1 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 CDW57392.1 - 4.9e-09 36.5 2.1 0.0042 17.5 0.1 4.5 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW57392.1 - 4.4e-07 29.0 2.1 0.017 14.7 0.0 4.5 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 CDW57392.1 - 4.6e-07 29.6 1.7 0.059 13.2 0.0 5.1 5 0 0 5 5 5 2 EF-hand domain pair EF-hand_6 PF13405.6 CDW57392.1 - 0.00052 19.7 4.6 0.92 9.6 0.0 4.9 6 0 0 6 6 6 2 EF-hand domain EF-hand_5 PF13202.6 CDW57392.1 - 0.001 18.5 0.1 0.16 11.5 0.1 2.8 2 0 0 2 2 2 1 EF hand Neur_chan_LBD PF02931.23 CDW57393.1 - 1e-44 152.6 0.2 1.7e-44 151.9 0.2 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW57393.1 - 9.8e-30 104.4 2.3 6.6e-29 101.6 2.3 2.0 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ank_2 PF12796.7 CDW57394.1 - 1.2e-127 416.7 37.2 1.9e-17 63.6 0.1 12.0 3 2 7 11 11 11 11 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW57394.1 - 9.4e-102 320.6 35.9 1.8e-05 24.7 0.0 26.0 25 1 1 26 26 26 20 Ankyrin repeat Ank_4 PF13637.6 CDW57394.1 - 3.7e-99 323.9 31.5 3.7e-12 46.5 0.2 16.0 6 3 10 18 18 18 17 Ankyrin repeats (many copies) Ank PF00023.30 CDW57394.1 - 3.4e-91 296.0 50.9 2.2e-07 31.0 0.1 22.9 23 0 0 23 23 23 18 Ankyrin repeat Ank_5 PF13857.6 CDW57394.1 - 9e-74 242.6 39.9 1.2e-08 35.0 0.1 19.1 11 6 11 22 22 22 16 Ankyrin repeats (many copies) Ion_trans PF00520.31 CDW57394.1 - 0.0017 17.6 26.2 0.0043 16.3 26.2 1.8 1 1 0 1 1 1 1 Ion transport protein PX PF00787.24 CDW57395.1 - 3.1e-28 98.0 0.1 3.8e-28 97.7 0.1 1.1 1 0 0 1 1 1 1 PX domain RdRP_1 PF00680.20 CDW57395.1 - 0.11 11.0 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 RNA dependent RNA polymerase DNase_II PF03265.15 CDW57396.1 - 5.9e-47 160.5 3.6 7.4e-47 160.2 3.6 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II DNase_II PF03265.15 CDW57397.1 - 1.7e-47 162.3 0.3 2.1e-47 162.0 0.3 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II Pkinase PF00069.25 CDW57398.1 - 2.6e-13 50.0 0.0 3.1e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57398.1 - 5.1e-08 32.5 0.0 7.5e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW57398.1 - 0.038 13.3 0.0 0.067 12.5 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 CDW57398.1 - 0.042 13.2 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MarR PF01047.22 CDW57399.1 - 0.15 12.0 0.0 0.44 10.5 0.0 1.9 1 0 0 1 1 1 0 MarR family EF-hand_8 PF13833.6 CDW57400.1 - 3.7e-14 52.3 2.9 1.2e-13 50.7 1.0 2.3 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 CDW57400.1 - 4e-12 46.4 2.0 5.7e-11 42.7 0.6 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CDW57400.1 - 4.7e-12 44.5 2.4 2.9e-08 32.7 0.7 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 CDW57400.1 - 1.5e-07 30.8 1.2 0.0015 18.3 0.1 4.0 3 2 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 CDW57400.1 - 1.7e-06 27.2 4.8 0.0002 20.7 0.2 3.9 3 1 1 4 4 4 1 EF hand SurA_N_3 PF13624.6 CDW57400.1 - 0.0025 17.6 0.1 0.0048 16.7 0.1 1.5 2 0 0 2 2 2 1 SurA N-terminal domain EF-hand_4 PF12763.7 CDW57400.1 - 0.0097 15.8 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CDW57400.1 - 0.011 15.9 0.0 0.04 14.1 0.0 1.8 2 0 0 2 2 2 0 Dockerin type I domain SurA_N_2 PF13623.6 CDW57400.1 - 0.019 14.8 0.2 0.036 13.9 0.1 1.5 2 0 0 2 2 2 0 SurA N-terminal domain SRI PF08236.11 CDW57400.1 - 0.022 14.9 0.3 0.077 13.2 0.0 2.0 2 1 1 3 3 2 0 SRI (Set2 Rpb1 interacting) domain DUF3008 PF11450.8 CDW57400.1 - 0.061 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknwon function (DUF3008) PMBR PF09373.10 CDW57400.1 - 0.061 13.5 1.1 46 4.4 0.0 3.5 3 1 1 4 4 4 0 Pseudomurein-binding repeat EF-hand_10 PF14788.6 CDW57400.1 - 0.26 11.2 4.1 1.8 8.5 2.0 2.3 2 0 0 2 2 2 0 EF hand CUB PF00431.20 CDW57401.1 - 1.1e-30 106.2 9.1 1.6e-12 47.8 0.5 5.7 6 0 0 6 6 6 3 CUB domain EGF PF00008.27 CDW57401.1 - 2.1e-16 59.9 104.9 0.00045 20.5 6.6 9.2 9 0 0 9 9 9 7 EGF-like domain hEGF PF12661.7 CDW57401.1 - 4.3e-05 24.0 16.8 0.00036 21.0 4.6 9.3 9 0 0 9 9 9 4 Human growth factor-like EGF CUB_2 PF02408.20 CDW57401.1 - 0.0054 16.5 12.6 0.0094 15.7 0.1 4.6 4 1 0 4 4 4 1 CUB-like domain Plasmod_Pvs28 PF06247.11 CDW57401.1 - 0.011 16.0 6.3 0.011 16.0 6.3 8.3 7 2 1 8 8 8 0 Pvs28 EGF domain EGF_CA PF07645.15 CDW57401.1 - 0.012 15.8 3.5 0.012 15.8 3.5 8.1 5 2 3 8 8 8 0 Calcium-binding EGF domain Pectate_lyase_3 PF12708.7 CDW57401.1 - 0.015 15.1 0.1 0.048 13.5 0.1 1.9 1 0 0 1 1 1 0 Pectate lyase superfamily protein Glutaredoxin PF00462.24 CDW57402.1 - 1.6e-15 57.1 0.1 2.1e-15 56.6 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_4 PF13462.6 CDW57402.1 - 0.0042 17.2 0.5 1.3 9.2 0.4 2.1 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_3 PF13192.6 CDW57402.1 - 0.0051 16.8 0.0 0.01 15.8 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.14 CDW57402.1 - 0.0064 16.9 0.0 0.0084 16.5 0.0 1.3 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 CDW57402.1 - 0.008 16.6 0.3 0.013 15.9 0.3 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 CDW57402.1 - 0.015 15.1 0.0 0.017 14.9 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin GST_N_3 PF13417.6 CDW57402.1 - 0.055 13.9 0.0 0.083 13.3 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain NIF PF03031.18 CDW57402.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase SEFIR PF08357.11 CDW57403.1 - 6.1e-08 33.1 0.2 1.4e-07 31.9 0.1 1.7 1 1 0 1 1 1 1 SEFIR domain TIR_2 PF13676.6 CDW57403.1 - 0.00012 22.7 0.0 0.00027 21.5 0.0 1.6 1 0 0 1 1 1 1 TIR domain zf-ribbon_3 PF13248.6 CDW57405.1 - 0.033 13.6 0.1 0.054 12.9 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Claudin_2 PF13903.6 CDW57406.1 - 4.9e-09 36.2 8.1 6.7e-09 35.8 8.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 CDW57406.1 - 1.6e-08 34.6 11.9 3.2e-06 27.1 11.9 2.1 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family Clc-like PF07062.12 CDW57406.1 - 6.9e-07 28.9 9.4 1.6e-06 27.7 9.4 1.6 1 1 0 1 1 1 1 Clc-like DUF4405 PF14358.6 CDW57406.1 - 0.039 14.5 0.3 0.039 14.5 0.3 2.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) Prominin PF05478.11 CDW57406.1 - 0.36 8.7 3.7 0.49 8.3 3.7 1.1 1 0 0 1 1 1 0 Prominin SUR7 PF06687.12 CDW57406.1 - 3.5 7.2 14.5 12 5.5 14.5 1.8 1 1 0 1 1 1 0 SUR7/PalI family tRNA-synt_1g PF09334.11 CDW57407.1 - 1.3e-149 498.2 0.4 2e-149 497.6 0.4 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA_bind PF01588.20 CDW57407.1 - 5.4e-29 100.1 0.1 1.1e-28 99.2 0.1 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain tRNA-synt_1 PF00133.22 CDW57407.1 - 4.6e-08 31.8 0.3 9.9e-05 20.8 0.0 3.1 2 1 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDW57407.1 - 0.0033 17.4 0.0 0.0086 16.0 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Lipase_3 PF01764.25 CDW57408.1 - 9.1e-15 54.8 0.0 1.6e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CDW57408.1 - 0.064 13.8 0.4 8.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Alpha/beta hydrolase family BCAS2 PF05700.11 CDW57409.1 - 1.1e-64 218.0 6.3 2e-64 217.1 6.3 1.4 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Ribosomal_S4 PF00163.19 CDW57409.1 - 1.3e-07 32.4 0.3 5.8e-07 30.3 0.3 2.1 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 CDW57409.1 - 1.3e-05 24.8 0.8 3.5e-05 23.4 0.8 1.8 1 0 0 1 1 1 1 S4 domain MscS_porin PF12795.7 CDW57409.1 - 8.3 5.9 13.6 0.3 10.6 7.3 1.9 2 1 0 2 2 2 0 Mechanosensitive ion channel porin domain Nup188 PF10487.9 CDW57410.1 - 8.4e-31 106.7 5.4 1.6e-30 105.9 5.4 1.4 1 0 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 Metallophos PF00149.28 CDW57413.1 - 7.8e-34 118.0 0.0 1e-33 117.6 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDW57413.1 - 0.16 12.1 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 CDW57413.1 - 0.16 12.4 0.1 1.4 9.4 0.0 2.4 3 0 0 3 3 3 0 Serine-threonine protein phosphatase N-terminal domain AAA_6 PF12774.7 CDW57414.1 - 3.8e-127 423.8 0.1 3.4e-125 417.4 0.0 3.3 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CDW57414.1 - 2.2e-113 379.4 8.0 2.2e-113 379.4 8.0 5.5 6 0 0 6 6 5 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 CDW57414.1 - 8.1e-110 368.1 2.7 8.1e-110 368.1 2.7 5.7 7 0 0 7 7 7 1 Dynein heavy chain, N-terminal region 1 AAA_8 PF12780.7 CDW57414.1 - 4.1e-71 239.4 0.0 1e-69 234.8 0.0 3.1 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 CDW57414.1 - 1.4e-68 230.3 0.0 1.4e-68 230.3 0.0 3.9 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 CDW57414.1 - 1.2e-41 142.3 0.0 2.1e-35 121.9 0.0 4.1 4 0 0 4 4 4 2 P-loop containing dynein motor region MT PF12777.7 CDW57414.1 - 5.4e-33 114.5 22.1 9.3e-24 84.1 1.0 2.7 2 1 1 3 3 3 2 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 CDW57414.1 - 1.2e-27 96.6 0.0 7.8e-12 45.4 0.0 5.8 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 CDW57414.1 - 1.5e-18 67.2 0.2 5.9e-18 65.2 0.2 2.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 CDW57414.1 - 2.1e-13 50.7 0.2 0.013 15.8 0.0 6.8 6 1 0 6 6 4 3 AAA domain AAA PF00004.29 CDW57414.1 - 6.7e-13 49.2 0.0 0.013 15.9 0.0 5.7 5 0 0 5 5 5 3 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CDW57414.1 - 2e-08 34.5 0.2 0.04 14.1 0.0 5.6 5 0 0 5 5 5 2 AAA domain AAA_16 PF13191.6 CDW57414.1 - 2.6e-08 34.4 0.0 4.8 7.5 0.0 7.0 6 0 0 6 6 5 1 AAA ATPase domain AAA_18 PF13238.6 CDW57414.1 - 2e-06 28.3 1.7 19 5.8 0.0 6.5 6 0 0 6 6 5 0 AAA domain Mg_chelatase PF01078.21 CDW57414.1 - 1.4e-05 24.5 0.2 0.37 10.1 0.0 4.3 5 0 0 5 5 5 2 Magnesium chelatase, subunit ChlI AAA_lid_1 PF17857.1 CDW57414.1 - 0.00029 21.0 0.0 0.0025 18.0 0.0 2.5 2 0 0 2 2 2 1 AAA+ lid domain AAA_30 PF13604.6 CDW57414.1 - 0.0003 20.6 0.1 19 4.9 0.0 4.6 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 CDW57414.1 - 0.001 19.4 0.2 0.62 10.4 0.0 4.4 4 0 0 4 4 4 1 AAA domain T2SSE PF00437.20 CDW57414.1 - 0.0011 18.1 0.0 0.22 10.6 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 CDW57414.1 - 0.013 15.3 0.9 0.63 9.8 0.0 3.9 5 0 0 5 5 4 0 IstB-like ATP binding protein RFX5_N PF18326.1 CDW57414.1 - 0.021 14.6 0.1 0.1 12.4 0.1 2.2 1 0 0 1 1 1 0 RFX5 N-terminal domain RNA_helicase PF00910.22 CDW57414.1 - 0.028 14.8 0.5 86 3.6 0.0 4.8 6 0 0 6 6 4 0 RNA helicase FtsK_SpoIIIE PF01580.18 CDW57414.1 - 0.032 13.6 0.0 3.2 7.1 0.0 3.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_29 PF13555.6 CDW57414.1 - 0.038 13.7 0.0 26 4.7 0.0 3.6 3 0 0 3 3 3 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CDW57414.1 - 0.043 13.5 0.0 14 5.3 0.0 3.7 3 0 0 3 3 3 0 AAA domain RST PF12174.8 CDW57414.1 - 0.044 13.7 0.2 16 5.5 0.1 3.4 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain NACHT PF05729.12 CDW57414.1 - 1.3 8.9 7.1 17 5.3 0.0 4.8 5 0 0 5 5 3 0 NACHT domain ABC_tran PF00005.27 CDW57414.1 - 3.5 8.1 9.3 9.6 6.7 0.0 5.2 5 0 0 5 5 3 0 ABC transporter HLH PF00010.26 CDW57415.1 - 6.7e-17 61.2 1.9 6.7e-17 61.2 1.9 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain MAJIN PF15077.6 CDW57415.1 - 0.15 11.8 2.2 0.21 11.4 2.2 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Astacin PF01400.24 CDW57416.1 - 4.8e-67 225.3 0.0 8.4e-67 224.5 0.0 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 CDW57416.1 - 1.2e-11 44.9 0.0 2.1e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 CUB domain Peptidase_M10 PF00413.24 CDW57416.1 - 5.4e-05 23.1 0.1 0.0015 18.4 0.0 2.1 2 0 0 2 2 2 1 Matrixin Peptidase_M66 PF10462.9 CDW57416.1 - 0.0061 15.6 0.5 0.0093 14.9 0.5 1.2 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_4 PF13583.6 CDW57416.1 - 0.0098 15.6 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 CDW57416.1 - 0.018 14.6 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_3 PF13582.6 CDW57416.1 - 0.11 13.1 0.1 0.2 12.2 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 CDW57416.1 - 0.22 10.1 0.1 0.34 9.5 0.1 1.1 1 0 0 1 1 1 0 Putative peptidase family HLH PF00010.26 CDW57417.1 - 2.8e-17 62.4 3.6 5.7e-17 61.4 3.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF2258 PF10015.9 CDW57417.1 - 0.052 13.7 0.2 0.1 12.7 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) RabGAP-TBC PF00566.18 CDW57418.1 - 9.5e-49 166.0 2.5 1.4e-48 165.5 2.5 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SUIM_assoc PF16619.5 CDW57418.1 - 0.035 14.2 3.4 0.037 14.1 0.7 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Brix PF04427.18 CDW57419.1 - 1.9e-29 103.2 0.3 2.7e-29 102.6 0.3 1.2 1 0 0 1 1 1 1 Brix domain HTH_Tnp_Tc5 PF03221.16 CDW57420.1 - 2.2e-13 50.0 0.1 5e-13 48.9 0.2 1.6 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 CDW57420.1 - 1.1e-05 25.0 2.9 1.1e-05 24.9 1.2 1.9 2 0 0 2 2 2 1 CENP-B N-terminal DNA-binding domain DUF2481 PF10654.9 CDW57420.1 - 0.0018 18.3 0.3 0.0031 17.5 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2481) HTH_50 PF18024.1 CDW57420.1 - 0.01 15.4 1.1 0.033 13.8 0.2 2.2 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 CDW57420.1 - 0.028 14.2 0.3 0.028 14.2 0.3 2.4 3 1 0 3 3 3 0 Homeodomain-like domain UPF0122 PF04297.14 CDW57420.1 - 0.051 13.8 0.3 0.15 12.3 0.2 1.8 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like CUT PF02376.15 CDW57421.1 - 1.3e-17 63.8 0.7 2.3e-17 62.9 0.7 1.4 1 0 0 1 1 1 1 CUT domain Homeodomain PF00046.29 CDW57421.1 - 1e-09 38.1 2.0 1.8e-09 37.3 2.0 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW57421.1 - 0.0087 15.9 0.2 0.02 14.8 0.2 1.6 1 0 0 1 1 1 1 Homeobox KN domain RRM_1 PF00076.22 CDW57422.1 - 2.5e-07 30.4 0.0 4.7e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW57422.1 - 0.0029 17.2 0.0 0.0043 16.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_1 PF00001.21 CDW57423.1 - 0.047 13.0 15.9 0.067 12.5 15.9 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) OAD_gamma PF04277.13 CDW57423.1 - 4.9 7.8 5.3 3.2 8.4 0.1 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Abi_HHR PF07815.14 CDW57424.1 - 7.2e-25 87.0 0.2 1.6e-24 85.8 0.2 1.6 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.6 CDW57424.1 - 8.1e-18 64.0 0.2 1.8e-17 62.9 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW57424.1 - 6e-16 57.8 0.1 1e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CDW57424.1 - 4.9e-13 48.6 0.0 9.7e-13 47.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain UPF0128 PF03673.13 CDW57424.1 - 0.087 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Ras PF00071.22 CDW57425.1 - 1.2e-52 177.8 0.0 1.4e-52 177.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW57425.1 - 6.6e-31 107.0 0.0 9e-31 106.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW57425.1 - 2.2e-15 56.5 0.0 2.9e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW57425.1 - 0.00029 20.9 0.0 0.00046 20.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW57425.1 - 0.0013 18.2 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDW57425.1 - 0.01 15.7 0.2 0.19 11.6 0.2 2.3 1 1 2 3 3 3 0 RsgA GTPase AAA_5 PF07728.14 CDW57425.1 - 0.022 14.8 0.2 0.056 13.5 0.2 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) GTP_EFTU PF00009.27 CDW57425.1 - 0.024 14.1 0.1 0.05 13.1 0.0 1.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDW57425.1 - 0.052 13.9 0.3 0.079 13.3 0.3 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CDW57425.1 - 0.078 12.5 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 CDW57425.1 - 0.12 12.8 1.4 0.6 10.5 0.7 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW57425.1 - 0.13 12.6 0.3 0.28 11.5 0.3 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 CDW57425.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 CDW57425.1 - 0.19 11.5 0.1 2.8 7.7 0.0 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 CDW57425.1 - 0.21 11.3 0.3 0.51 10.0 0.2 1.6 2 0 0 2 2 2 0 AAA domain SDA1 PF05285.12 CDW57426.1 - 0.0024 17.3 11.9 0.0027 17.2 11.9 1.1 1 0 0 1 1 1 1 SDA1 Tim54 PF11711.8 CDW57426.1 - 0.0085 14.9 4.1 0.011 14.6 4.1 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 CDW57426.1 - 0.019 15.1 3.5 0.026 14.7 3.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4471 PF14740.6 CDW57426.1 - 0.03 13.6 0.4 0.029 13.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Nop14 PF04147.12 CDW57426.1 - 0.038 12.2 15.8 0.043 12.0 15.8 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 CDW57426.1 - 0.044 13.1 11.3 0.053 12.9 11.3 1.1 1 0 0 1 1 1 0 BUD22 Zip PF02535.22 CDW57426.1 - 0.064 12.5 0.1 0.074 12.3 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 CDW57426.1 - 0.069 12.5 15.4 0.089 12.2 15.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 CDW57426.1 - 0.087 12.0 8.8 0.12 11.6 8.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Roughex PF06020.11 CDW57426.1 - 0.11 11.6 7.7 0.13 11.3 7.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Vfa1 PF08432.10 CDW57426.1 - 0.13 12.6 7.1 0.17 12.2 7.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RPN2_C PF18004.1 CDW57426.1 - 0.13 12.2 9.8 0.18 11.7 9.8 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF5308 PF17233.2 CDW57426.1 - 0.17 12.1 0.4 0.3 11.3 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5308) NPR3 PF03666.13 CDW57426.1 - 0.18 10.6 2.5 0.21 10.3 2.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.11 CDW57426.1 - 0.2 11.1 7.0 0.25 10.8 7.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DNA_pol_phi PF04931.13 CDW57426.1 - 0.23 9.5 23.2 0.3 9.1 23.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi PTPRCAP PF15713.5 CDW57426.1 - 0.28 11.5 17.1 0.37 11.1 17.1 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated ORC_WH_C PF18137.1 CDW57426.1 - 0.29 11.2 6.0 0.45 10.6 6.0 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal RR_TM4-6 PF06459.12 CDW57426.1 - 0.36 10.6 10.1 0.46 10.3 10.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPL5 PF18168.1 CDW57426.1 - 0.38 10.0 2.6 0.48 9.7 2.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF913 PF06025.12 CDW57426.1 - 0.46 9.4 2.2 0.62 9.0 2.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MDM1 PF15501.6 CDW57426.1 - 0.58 9.2 11.5 0.73 8.9 11.5 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 Afi1 PF07792.12 CDW57426.1 - 0.59 10.6 7.7 0.85 10.1 7.7 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Paf1 PF03985.13 CDW57426.1 - 0.89 8.5 19.7 1.2 8.1 19.7 1.1 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.14 CDW57426.1 - 0.94 7.7 13.7 1.6 7.0 13.7 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4637 PF15470.6 CDW57426.1 - 1.4 8.6 16.6 2.1 8.1 16.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DARPP-32 PF05395.12 CDW57426.1 - 1.4 9.1 14.6 1.9 8.7 14.6 1.1 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 RNA_pol_Rpc4 PF05132.14 CDW57426.1 - 1.8 8.9 6.1 2.5 8.5 6.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 YqfQ PF14181.6 CDW57426.1 - 4.2 7.5 9.2 6.3 7.0 9.2 1.2 1 0 0 1 1 1 0 YqfQ-like protein DUF4820 PF16091.5 CDW57426.1 - 4.3 6.7 6.1 6.2 6.1 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TFB6 PF17110.5 CDW57426.1 - 4.5 7.0 11.2 4.6 6.9 8.7 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH V_ATPase_I PF01496.19 CDW57426.1 - 5.9 4.7 7.1 8 4.2 7.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2457 PF10446.9 CDW57426.1 - 6.7 5.7 25.5 8.2 5.4 25.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TPR_2 PF07719.17 CDW57427.1 - 2.4e-15 55.3 1.6 0.24 11.6 0.0 5.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDW57427.1 - 3.2e-12 45.7 6.3 0.095 12.6 0.0 6.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 CDW57427.1 - 2.1e-11 44.3 0.2 1.9e-06 28.4 0.1 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDW57427.1 - 3.7e-10 39.2 0.2 0.0051 16.9 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW57427.1 - 1.1e-09 37.8 1.7 0.00031 20.4 0.0 5.6 5 1 1 6 6 6 1 TPR repeat TPR_12 PF13424.6 CDW57427.1 - 3.2e-09 37.0 0.4 0.062 13.6 0.0 4.7 3 2 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDW57427.1 - 7.2e-09 35.7 0.1 0.055 14.3 0.0 5.0 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDW57427.1 - 2.7e-07 30.6 0.1 0.07 13.3 0.0 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW57427.1 - 2e-05 24.9 0.1 0.35 11.6 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW57427.1 - 7.1e-05 22.9 0.1 0.54 10.8 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW57427.1 - 0.00075 19.7 3.1 3.2 8.0 0.4 3.9 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CDW57427.1 - 0.0011 18.9 0.2 11 6.3 0.0 4.5 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDW57427.1 - 0.035 14.0 0.0 3.1 7.8 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDW57427.1 - 0.15 12.6 0.2 93 3.6 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Peptidase_M13_N PF05649.13 CDW57428.1 - 1.3e-90 304.8 7.4 5e-79 266.7 3.1 2.1 1 1 1 2 2 2 2 Peptidase family M13 Peptidase_M13 PF01431.21 CDW57428.1 - 8.2e-66 221.5 0.6 9.7e-64 214.7 0.1 3.5 3 1 0 3 3 3 1 Peptidase family M13 RasGAP_C PF03836.15 CDW57428.1 - 0.096 12.8 0.6 0.4 10.8 0.1 2.0 2 0 0 2 2 2 0 RasGAP C-terminus adh_short PF00106.25 CDW57429.1 - 5e-10 39.2 0.0 8.4e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW57429.1 - 2e-06 27.5 0.3 5.9e-06 26.0 0.1 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW57429.1 - 0.0011 19.0 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 KR domain Ribosomal_L9_N PF01281.19 CDW57430.1 - 6.8e-09 35.2 0.0 1e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Pkinase_Tyr PF07714.17 CDW57431.1 - 2.7e-52 177.6 0.0 4.6e-52 176.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW57431.1 - 9.6e-51 172.7 0.0 3e-50 171.0 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain C1_1 PF00130.22 CDW57431.1 - 6.8e-11 41.9 5.9 6.8e-11 41.9 5.9 2.1 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 CDW57431.1 - 6e-07 29.1 0.0 9.2e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDW57431.1 - 2.6e-05 23.2 0.0 4.3e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase C1_2 PF03107.16 CDW57431.1 - 0.00037 20.7 4.8 0.00037 20.7 2.1 2.2 2 0 0 2 2 2 1 C1 domain zf-RING-like PF08746.11 CDW57431.1 - 0.0036 17.6 3.3 0.011 16.0 3.3 1.9 1 0 0 1 1 1 1 RING-like domain Kdo PF06293.14 CDW57431.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PHD_2 PF13831.6 CDW57431.1 - 0.12 11.9 2.3 0.47 10.0 0.5 2.4 2 0 0 2 2 2 0 PHD-finger APH PF01636.23 CDW57431.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Zf_RING PF16744.5 CDW57431.1 - 0.43 10.7 6.4 1.9 8.6 2.4 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger PHD PF00628.29 CDW57431.1 - 2.6 8.0 8.9 8.3 6.4 5.9 2.5 2 0 0 2 2 2 0 PHD-finger RPE65 PF03055.15 CDW57432.1 - 1.2e-47 163.2 0.1 1.7e-47 162.7 0.1 1.1 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein BORCS6 PF10157.9 CDW57432.1 - 4.7e-08 33.4 0.0 7.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 Sec20 PF03908.13 CDW57434.1 - 0.003 17.4 0.1 0.0042 17.0 0.1 1.4 1 1 0 1 1 1 1 Sec20 Use1 PF09753.9 CDW57434.1 - 0.021 14.6 0.0 0.025 14.3 0.0 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 Neur_chan_LBD PF02931.23 CDW57435.1 - 2e-44 151.6 4.1 2.8e-44 151.2 4.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW57435.1 - 6e-23 82.1 4.3 4.6e-20 72.7 0.2 2.6 3 0 0 3 3 3 2 Neurotransmitter-gated ion-channel transmembrane region CtaG_Cox11 PF04442.14 CDW57436.1 - 2.9e-41 141.0 0.0 3.3e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 PFK PF00365.20 CDW57437.1 - 1.4e-184 612.0 1.4 1.1e-91 307.1 0.0 3.4 4 0 0 4 4 4 3 Phosphofructokinase CBM_14 PF01607.24 CDW57439.1 - 2.3e-74 245.4 122.9 6.8e-11 42.2 6.7 13.2 12 1 1 13 13 13 13 Chitin binding Peritrophin-A domain UCH PF00443.29 CDW57440.1 - 1.6e-43 149.1 0.2 2e-43 148.8 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW57440.1 - 1.3e-05 25.0 4.8 0.00016 21.4 4.8 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CDW57440.1 - 0.014 15.2 0.1 0.047 13.5 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin family HTH_37 PF13744.6 CDW57440.1 - 0.11 12.5 0.2 0.21 11.6 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain ATP-grasp_4 PF13535.6 CDW57441.1 - 0.0023 17.5 0.0 0.017 14.8 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 CDW57441.1 - 0.0031 17.6 0.0 0.0056 16.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CDW57442.1 - 2.7e-07 30.3 0.0 4.4e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_4 PF13535.6 CDW57442.1 - 0.0002 21.0 0.0 0.00071 19.2 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain Kelch_1 PF01344.25 CDW57443.1 - 2.8e-86 282.9 17.3 1.6e-15 56.4 0.2 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 CDW57443.1 - 1.5e-48 161.5 4.9 4.2e-08 33.2 0.0 6.5 2 2 4 6 6 6 6 Kelch motif BACK PF07707.15 CDW57443.1 - 8.5e-36 122.2 2.0 9.3e-36 122.0 0.4 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 CDW57443.1 - 2.3e-31 108.3 1.5 4.2e-31 107.4 1.5 1.4 1 0 0 1 1 1 1 BTB/POZ domain Kelch_2 PF07646.15 CDW57443.1 - 2e-30 103.6 6.3 0.00021 21.2 0.0 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_4 PF13418.6 CDW57443.1 - 1.1e-29 102.2 4.3 0.00021 21.2 0.0 6.3 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 CDW57443.1 - 5.9e-20 71.1 12.6 0.00037 20.7 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 CDW57443.1 - 7.5e-08 32.2 5.5 1.1 9.4 0.0 4.6 4 0 0 4 4 4 3 Kelch motif PQQ_3 PF13570.6 CDW57443.1 - 0.015 15.8 15.7 1.7 9.3 0.2 5.1 5 0 0 5 5 5 0 PQQ-like domain Glu_cyclase_2 PF05096.12 CDW57443.1 - 0.022 14.2 0.0 25 4.2 0.0 3.1 2 1 0 3 3 3 0 Glutamine cyclotransferase Neur_chan_LBD PF02931.23 CDW57444.1 - 3e-71 239.3 0.2 4.6e-71 238.7 0.2 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 CDW57444.1 - 1.9e-52 178.7 6.1 2.6e-52 178.3 6.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CBM_14 PF01607.24 CDW57445.1 - 3.3e-96 315.3 143.6 8.1e-10 38.7 5.6 12.3 12 0 0 12 12 12 12 Chitin binding Peritrophin-A domain Patched PF02460.18 CDW57446.1 - 9.8e-14 50.4 33.9 9.3e-08 30.6 12.3 2.3 2 0 0 2 2 2 2 Patched family MMPL PF03176.15 CDW57446.1 - 1.3e-08 34.1 9.8 1.3e-08 34.1 9.8 2.3 2 0 0 2 2 2 2 MMPL family Sterol-sensing PF12349.8 CDW57446.1 - 1.5e-08 34.7 15.2 1.5e-08 34.7 15.2 3.6 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation ETF_QO PF05187.13 CDW57447.1 - 3.1e-47 159.0 0.1 5e-47 158.3 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 CDW57447.1 - 1.1e-08 34.6 0.2 1.1e-05 24.8 0.6 2.1 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CDW57447.1 - 8.7e-08 31.7 0.0 2.1e-07 30.4 0.1 1.5 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 CDW57447.1 - 1.9e-07 31.0 0.3 0.00019 21.1 0.3 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDW57447.1 - 4.4e-07 30.0 0.0 1.1e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CDW57447.1 - 3.1e-05 23.5 0.0 4.3e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CDW57447.1 - 3.2e-05 24.4 0.1 0.31 11.6 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CDW57447.1 - 8.4e-05 21.9 0.1 0.00019 20.8 0.1 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDW57447.1 - 0.00013 22.0 0.0 0.00033 20.7 0.1 1.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CDW57447.1 - 0.0011 18.3 0.3 0.0023 17.3 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 CDW57447.1 - 0.0011 18.1 0.1 0.0019 17.3 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 CDW57447.1 - 0.0013 17.5 0.2 0.002 16.9 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CDW57447.1 - 0.0039 16.5 0.1 0.0062 15.8 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CDW57447.1 - 0.011 14.6 0.6 0.24 10.2 0.1 3.0 4 0 0 4 4 4 0 Tryptophan halogenase K_oxygenase PF13434.6 CDW57447.1 - 0.019 14.1 0.0 0.028 13.6 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Fer4_7 PF12838.7 CDW57447.1 - 0.031 14.9 0.6 0.085 13.5 0.6 1.7 1 0 0 1 1 1 0 4Fe-4S dicluster domain GIDA PF01134.22 CDW57447.1 - 0.17 10.9 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A EGF_CA PF07645.15 CDW57448.1 - 1.1e-146 476.8 453.8 4e-08 33.3 5.3 39.0 39 0 0 39 39 38 33 Calcium-binding EGF domain EGF_3 PF12947.7 CDW57448.1 - 2.2e-105 344.5 438.7 2.1e-06 27.8 7.2 39.0 39 0 0 39 39 39 32 EGF domain EGF PF00008.27 CDW57448.1 - 7.8e-99 323.4 422.1 9.2e-06 25.9 2.9 39.6 39 0 0 39 39 38 33 EGF-like domain hEGF PF12661.7 CDW57448.1 - 2e-86 282.0 372.0 4.8e-05 23.8 1.8 40.6 39 0 0 39 39 39 31 Human growth factor-like EGF cEGF PF12662.7 CDW57448.1 - 4.5e-36 122.4 271.5 0.012 15.5 0.2 38.2 39 0 0 39 39 39 26 Complement Clr-like EGF-like VWA PF00092.28 CDW57448.1 - 1.2e-35 123.3 0.3 1.8e-35 122.7 0.3 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FXa_inhibition PF14670.6 CDW57448.1 - 3.9e-20 71.8 461.8 0.0084 16.4 3.3 39.0 39 0 0 39 39 38 25 Coagulation Factor Xa inhibitory site VWA_2 PF13519.6 CDW57448.1 - 1.1e-12 48.5 0.0 2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain EGF_MSP1_1 PF12946.7 CDW57448.1 - 4.3e-07 29.9 312.9 0.00023 21.1 0.6 33.0 32 0 0 32 32 32 18 MSP1 EGF domain 1 SEA PF01390.20 CDW57448.1 - 4e-05 23.7 0.1 0.00018 21.5 0.0 2.0 2 0 0 2 2 2 1 SEA domain Plasmod_Pvs28 PF06247.11 CDW57448.1 - 0.0032 17.7 3.9 0.0032 17.7 3.9 36.9 38 1 0 38 38 37 21 Pvs28 EGF domain Ldl_recept_a PF00057.18 CDW57449.1 - 1.8e-13 50.4 39.4 1.2e-05 25.4 3.5 8.2 7 2 3 10 10 10 4 Low-density lipoprotein receptor domain class A EGF_CA PF07645.15 CDW57449.1 - 1.7e-12 47.3 29.5 2.8e-06 27.4 2.8 8.3 8 1 0 8 8 8 4 Calcium-binding EGF domain hEGF PF12661.7 CDW57449.1 - 2.5e-09 37.4 18.4 0.00029 21.3 2.4 8.9 8 1 0 8 8 8 4 Human growth factor-like EGF EGF PF00008.27 CDW57449.1 - 1e-07 32.1 24.8 8.5e-05 22.8 4.0 8.8 9 0 0 9 9 9 4 EGF-like domain EGF_3 PF12947.7 CDW57449.1 - 1.1e-06 28.7 28.8 0.00029 21.0 2.9 7.8 7 1 0 7 7 7 4 EGF domain Plasmod_Pvs28 PF06247.11 CDW57449.1 - 0.019 15.2 2.3 0.019 15.2 2.3 7.0 6 1 0 6 6 6 0 Pvs28 EGF domain FXa_inhibition PF14670.6 CDW57449.1 - 0.023 15.0 5.5 0.023 15.0 5.5 8.8 7 3 1 8 8 8 0 Coagulation Factor Xa inhibitory site WD40 PF00400.32 CDW57450.1 - 4.6e-15 55.8 10.7 7.9e-07 29.7 0.9 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat DUF3449 PF11931.8 CDW57451.1 - 1.4e-72 243.4 0.4 5.1e-72 241.5 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) Telomere_Sde2_2 PF13297.6 CDW57451.1 - 4.6e-27 93.4 0.7 9.6e-27 92.4 0.7 1.6 1 0 0 1 1 1 1 Telomere stability C-terminal SF3A3 PF16837.5 CDW57451.1 - 2.6e-23 82.3 1.0 9.5e-23 80.5 1.0 2.0 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 CDW57451.1 - 1.5e-08 34.3 0.1 3.3e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain DUF1858 PF08984.11 CDW57451.1 - 0.014 15.6 0.2 5.2 7.3 0.0 3.7 4 1 0 4 4 4 0 Domain of unknown function (DUF1858) zf-C2H2_4 PF13894.6 CDW57451.1 - 0.09 13.7 1.2 0.34 11.9 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger SlyX PF04102.12 CDW57451.1 - 1.6 9.4 4.3 7.3 7.3 0.3 3.4 2 1 0 2 2 2 0 SlyX Lzipper-MIP1 PF14389.6 CDW57451.1 - 2.5 8.5 7.4 0.42 10.9 0.7 2.7 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 zf-met PF12874.7 CDW57452.1 - 1.8e-05 25.0 10.4 0.041 14.3 0.3 3.8 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CDW57452.1 - 0.00013 22.5 20.4 0.027 15.3 0.6 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW57452.1 - 0.00058 20.2 20.2 0.034 14.6 0.4 4.8 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW57452.1 - 0.0034 17.7 4.5 0.74 10.4 0.1 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_3rep PF18868.1 CDW57452.1 - 0.34 11.6 8.3 0.94 10.2 0.2 3.4 3 0 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-AN1 PF01428.16 CDW57452.1 - 3.9 7.7 8.7 3.3 7.9 0.2 3.5 3 0 0 3 3 3 0 AN1-like Zinc finger ATG16 PF08614.11 CDW57453.1 - 0.14 12.4 0.3 0.17 12.1 0.3 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Apt1 PF10351.9 CDW57453.1 - 0.16 10.8 3.1 0.16 10.8 3.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pheromone PF08015.11 CDW57453.1 - 0.23 12.5 12.5 0.38 11.8 12.5 1.4 1 0 0 1 1 1 0 Fungal mating-type pheromone CCDC24 PF15669.5 CDW57453.1 - 0.38 10.6 7.5 0.46 10.3 7.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Macoilin PF09726.9 CDW57453.1 - 0.38 9.2 6.3 0.36 9.3 6.3 1.0 1 0 0 1 1 1 0 Macoilin family SSP160 PF06933.11 CDW57453.1 - 0.53 8.4 18.3 0.59 8.3 18.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PAP1 PF08601.10 CDW57453.1 - 2.1 8.0 13.5 2.2 7.9 13.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 AF-4 PF05110.13 CDW57453.1 - 4.2 5.3 18.9 4.3 5.3 18.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Ly-6_related PF06579.12 CDW57454.1 - 2.6e-36 124.6 1.8 2.6e-36 124.6 1.8 1.4 2 0 0 2 2 2 1 Caenorhabditis elegans ly-6-related protein 7tm_2 PF00002.24 CDW57455.1 - 9.7e-59 198.6 24.5 1.4e-58 198.1 24.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 CDW57455.1 - 4.9e-24 84.9 1.2 7e-24 84.4 1.2 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain GPS PF01825.21 CDW57455.1 - 3.1e-16 59.6 4.9 3.1e-16 59.6 4.9 3.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Gal_Lectin PF02140.18 CDW57455.1 - 1.9e-15 57.1 1.3 1.9e-15 57.1 1.3 3.2 4 0 0 4 4 4 1 Galactose binding lectin domain HRM PF02793.22 CDW57455.1 - 0.00036 20.8 0.0 0.00036 20.8 0.0 3.5 3 0 0 3 3 3 1 Hormone receptor domain Dicty_CAR PF05462.11 CDW57455.1 - 0.023 13.9 20.5 0.0072 15.5 17.7 1.6 2 0 0 2 2 2 0 Slime mold cyclic AMP receptor YjeF_N PF03853.15 CDW57456.1 - 1.8e-28 99.5 0.1 2.6e-17 63.2 0.0 2.1 2 0 0 2 2 2 2 YjeF-related protein N-terminus LRR_9 PF14580.6 CDW57457.1 - 1.6e-11 44.0 0.0 2.2e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 CDW57457.1 - 9.7e-11 41.7 18.0 1.7e-06 28.2 5.6 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDW57457.1 - 8.8e-07 28.6 16.2 3.6e-06 26.6 3.3 2.4 1 1 2 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 CDW57457.1 - 0.0046 17.3 8.8 2.5 9.0 0.1 3.7 3 0 0 3 3 3 2 Leucine Rich Repeat LRR_6 PF13516.6 CDW57457.1 - 0.015 15.3 8.6 6.7 7.0 0.7 3.6 3 0 0 3 3 3 0 Leucine Rich repeat CDC45 PF02724.14 CDW57457.1 - 0.075 11.3 20.0 0.081 11.2 20.0 1.1 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 CDW57457.1 - 0.32 9.7 6.0 0.33 9.7 6.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SDA1 PF05285.12 CDW57457.1 - 7.2 5.9 34.7 9.4 5.6 34.7 1.1 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 CDW57457.1 - 9.2 5.8 26.1 16 5.0 26.1 1.4 1 0 0 1 1 1 0 PPP4R2 Hydrolase_4 PF12146.8 CDW57459.1 - 6.1e-13 48.6 0.1 5e-07 29.2 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDW57459.1 - 3.9e-07 30.0 0.5 0.0047 16.6 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDW57459.1 - 5.1e-07 29.4 0.0 1.9e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CDW57459.1 - 3.2e-06 27.9 1.4 9.9e-05 23.0 0.0 2.3 2 1 1 3 3 3 1 Alpha/beta hydrolase family FSH1 PF03959.13 CDW57459.1 - 0.00039 20.2 0.0 0.0006 19.5 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 CDW57459.1 - 0.00082 19.0 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Asp2 PF16929.5 CDW57459.1 - 0.007 15.4 0.0 0.01 14.9 0.0 1.1 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter Peptidase_S15 PF02129.18 CDW57459.1 - 0.01 15.5 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 CDW57459.1 - 0.02 14.7 0.0 0.14 11.9 0.0 2.2 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase DUF818 PF05677.12 CDW57459.1 - 0.074 12.0 0.1 0.1 11.5 0.1 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) UPF0227 PF05728.12 CDW57459.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.7 CDW57459.1 - 0.2 11.4 0.0 0.37 10.5 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Seipin PF06775.14 CDW57460.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative adipose-regulatory protein (Seipin) HLH PF00010.26 CDW57461.1 - 7.3e-15 54.7 4.5 7.3e-15 54.7 4.5 1.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Hairy_orange PF07527.13 CDW57461.1 - 0.0061 16.7 0.0 0.029 14.6 0.0 2.1 2 0 0 2 2 2 1 Hairy Orange MCLC PF05934.11 CDW57462.1 - 1.8e-18 66.6 1.1 2.6e-18 66.1 1.1 1.1 1 0 0 1 1 1 1 Mid-1-related chloride channel (MCLC) MMR_HSR1 PF01926.23 CDW57462.1 - 1.9e-10 40.8 0.0 4.2e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CDW57462.1 - 7.1e-09 35.9 0.6 3.7e-06 27.1 0.0 3.0 2 1 1 3 3 3 1 Dynamin family Gtr1_RagA PF04670.12 CDW57462.1 - 1.6e-06 27.6 0.0 2.7e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region EF-hand_4 PF12763.7 CDW57462.1 - 2.7e-06 27.3 0.0 7.3e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand FeoB_N PF02421.18 CDW57462.1 - 3.3e-06 26.7 0.0 6e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 CDW57462.1 - 6.2e-05 22.4 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 CDW57462.1 - 0.00012 22.2 0.0 0.00096 19.4 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase EF-hand_1 PF00036.32 CDW57462.1 - 0.00076 18.9 0.4 0.0023 17.3 0.4 1.9 1 0 0 1 1 1 1 EF hand GTP_EFTU PF00009.27 CDW57462.1 - 0.00082 19.0 0.0 0.0053 16.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.22 CDW57462.1 - 0.0019 17.9 0.4 0.0076 15.9 0.0 2.1 2 1 0 2 2 2 1 Ras family RsgA_GTPase PF03193.16 CDW57462.1 - 0.002 18.0 0.1 0.84 9.5 0.0 2.8 2 1 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 CDW57462.1 - 0.014 14.8 0.0 0.032 13.7 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 CDW57462.1 - 0.014 15.8 0.1 0.08 13.3 0.0 2.3 3 0 0 3 3 2 0 AAA ATPase domain EF-hand_7 PF13499.6 CDW57462.1 - 0.017 15.5 0.4 0.72 10.3 0.0 2.9 3 0 0 3 3 2 0 EF-hand domain pair cobW PF02492.19 CDW57462.1 - 0.044 13.4 0.0 8.1 6.0 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TMEM132D_C PF15706.5 CDW57462.1 - 0.044 13.5 0.0 0.2 11.5 0.0 2.1 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term AAA_28 PF13521.6 CDW57462.1 - 0.076 13.3 0.0 0.24 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CDW57462.1 - 0.11 12.9 0.0 0.34 11.4 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zona_pellucida PF00100.23 CDW57463.1 - 1.5e-08 34.8 6.4 2.8e-08 33.9 6.1 1.6 2 0 0 2 2 2 1 Zona pellucida-like domain HCMV_UL124 PF17609.2 CDW57463.1 - 0.031 14.5 0.2 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function Dcc1 PF09724.9 CDW57464.1 - 6.6e-18 65.1 0.0 7.4e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 7tm_1 PF00001.21 CDW57465.1 - 0.0033 16.8 15.8 0.0047 16.3 15.7 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Virul_fac_BrkB PF03631.15 CDW57465.1 - 2.7 7.6 9.8 0.16 11.5 3.4 1.8 2 0 0 2 2 2 0 Virulence factor BrkB Carm_PH PF17888.1 CDW57466.1 - 4.1e-09 36.7 0.1 5.1e-09 36.4 0.1 1.1 1 0 0 1 1 1 1 Carmil pleckstrin homology domain Myosin_TH1 PF06017.13 CDW57466.1 - 0.065 12.9 0.0 0.077 12.7 0.0 1.1 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding Na_K-ATPase PF00287.18 CDW57468.1 - 6.8e-21 74.7 0.0 9.3e-21 74.2 0.0 1.1 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain Dickkopf_N PF04706.12 CDW57469.1 - 3.2e-10 40.3 71.6 0.0038 17.7 11.6 6.6 6 1 0 6 6 6 6 Dickkopf N-terminal cysteine-rich region EB PF01683.18 CDW57469.1 - 8.3e-10 38.8 70.3 0.001 19.3 9.3 7.5 4 3 4 8 8 8 7 EB module Toxin_23 PF08093.11 CDW57469.1 - 0.011 15.9 1.0 0.011 15.9 1.0 8.4 6 2 2 8 8 8 0 Magi 5 toxic peptide family CarbpepA_inh PF02977.15 CDW57469.1 - 1.3 8.9 60.7 2.7 7.8 10.8 6.7 3 3 2 5 5 5 0 Carboxypeptidase A inhibitor Trypsin PF00089.26 CDW57470.1 - 4.5e-05 23.4 0.0 8e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Trypsin FYDLN_acid PF09538.10 CDW57470.1 - 4 8.2 8.1 2.7 8.7 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) EST1_DNA_bind PF10373.9 CDW57471.1 - 1.1e-14 54.6 5.9 3.7e-14 52.9 5.9 1.9 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain TPR_12 PF13424.6 CDW57471.1 - 0.003 17.8 0.1 0.0069 16.7 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW57471.1 - 0.083 13.0 0.5 0.27 11.4 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat EST1 PF10374.9 CDW57471.1 - 0.18 12.4 2.1 1.1 9.9 0.3 3.2 2 1 1 3 3 3 0 Telomerase activating protein Est1 Proteasome PF00227.26 CDW57472.1 - 5.4e-35 120.6 0.0 7.2e-35 120.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit GRAM PF02893.20 CDW57472.1 - 4.4e-07 29.8 0.0 7.8e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.8 CDW57472.1 - 0.007 16.5 0.0 0.011 15.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 bPH_3 PF14470.6 CDW57472.1 - 0.12 12.7 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial PH domain GTP_cyclohydroI PF01227.22 CDW57473.1 - 5.6e-74 247.4 0.4 6.6e-74 247.2 0.4 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CDW57473.1 - 3e-06 27.3 0.0 6.1e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 QueF-like protein Ribosomal_L2_C PF03947.18 CDW57474.1 - 1.8e-49 167.2 0.9 3.3e-49 166.3 0.9 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CDW57474.1 - 7.4e-22 77.1 0.1 3.1e-21 75.1 0.2 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Collagen PF01391.18 CDW57475.1 - 2.8e-14 52.6 44.3 9.5e-06 25.3 31.4 3.9 2 1 0 2 2 2 2 Collagen triple helix repeat (20 copies) CHAD PF05235.14 CDW57475.1 - 0.035 14.1 0.0 0.045 13.7 0.0 1.1 1 0 0 1 1 1 0 CHAD domain Med21 PF11221.8 CDW57476.1 - 2.2e-20 73.4 5.1 2.9e-10 40.6 0.3 2.1 1 1 1 2 2 2 2 Subunit 21 of Mediator complex BAG6 PF12057.8 CDW57476.1 - 0.013 15.1 0.1 0.026 14.2 0.1 1.4 1 0 0 1 1 1 0 BCL2-associated athanogene 6 DUF1707 PF08044.11 CDW57476.1 - 0.13 12.4 0.9 9.6 6.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1707) Clat_adaptor_s PF01217.20 CDW57477.1 - 2.8e-33 114.9 5.4 1.4e-30 106.0 1.9 2.0 1 1 1 2 2 2 2 Clathrin adaptor complex small chain ATP-grasp_2 PF08442.10 CDW57478.1 - 4.7e-59 199.4 0.0 7.9e-59 198.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 CDW57478.1 - 3.4e-23 82.2 1.4 5.5e-23 81.5 1.4 1.3 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CDW57478.1 - 1.5e-07 31.1 0.1 3.4e-07 29.9 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain OKR_DC_1_N PF03709.15 CDW57478.1 - 0.057 13.7 0.7 13 6.1 0.0 2.4 1 1 1 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain Kinesin PF00225.23 CDW57479.1 - 1.9e-79 267.0 8.6 1e-77 261.3 8.6 2.1 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDW57479.1 - 2.4e-12 47.0 3.4 4.8e-10 39.6 3.4 2.5 1 1 0 1 1 1 1 Microtubule binding FAST_1 PF06743.15 CDW57479.1 - 0.15 12.1 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 FAST kinase-like protein, subdomain 1 AMP-binding PF00501.28 CDW57480.1 - 1.2e-101 340.3 0.0 1.6e-101 340.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW57480.1 - 3.2e-05 24.8 0.1 0.00015 22.7 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain CPW_WPC PF09717.10 CDW57481.1 - 0.2 12.6 1.1 0.52 11.3 1.1 1.6 1 0 0 1 1 1 0 Plasmodium falciparum domain of unknown function (CPW_WPC) DUF2701 PF10857.8 CDW57481.1 - 0.74 9.9 1.8 1.7 8.7 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2701) Histone_H2A_C PF16211.5 CDW57482.1 - 3.9e-19 68.1 0.1 7.9e-19 67.1 0.1 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW57482.1 - 4.9e-16 59.3 0.0 6.1e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW57482.1 - 8e-05 22.8 0.0 0.00011 22.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HMG_box PF00505.19 CDW57483.1 - 1.3e-07 31.9 0.1 3.6e-07 30.5 0.1 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW57483.1 - 0.00091 19.8 0.2 0.0036 17.9 0.2 2.0 1 0 0 1 1 1 1 HMG-box domain NCA2 PF08637.10 CDW57484.1 - 0.11 11.7 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 ATP synthase regulation protein NCA2 QVR PF17064.5 CDW57485.1 - 0.017 15.4 10.0 0.065 13.5 10.0 1.9 1 1 0 1 1 1 0 Sleepless protein zf-UBP_var PF17807.1 CDW57485.1 - 0.13 12.0 0.3 0.13 12.0 0.3 1.9 2 0 0 2 2 2 0 Variant UBP zinc finger bZIP_2 PF07716.15 CDW57487.1 - 8.8e-16 57.7 14.4 2.7e-15 56.2 14.4 1.9 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CDW57487.1 - 1.1e-06 28.7 9.9 2.2e-06 27.7 9.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 CDW57487.1 - 0.015 15.8 6.2 0.061 13.9 6.2 2.1 1 0 0 1 1 1 0 bZIP Maf transcription factor Sas10_Utp3 PF04000.15 CDW57488.1 - 5.3e-09 36.6 0.3 5.3e-09 36.6 0.3 1.8 2 0 0 2 2 2 1 Sas10/Utp3/C1D family CPSase_L_D2 PF02786.17 CDW57489.1 - 9.6e-76 254.0 0.1 1.7e-75 253.2 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 CDW57489.1 - 6.4e-71 238.2 0.0 1.1e-70 237.5 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 CDW57489.1 - 5.6e-43 146.0 0.1 1.3e-42 144.8 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDW57489.1 - 3.2e-31 107.6 0.0 1.8e-30 105.2 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 CDW57489.1 - 1.4e-27 96.9 0.0 4.1e-27 95.4 0.0 1.8 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 CDW57489.1 - 6e-17 61.2 2.2 1.9e-16 59.6 2.2 2.0 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CDW57489.1 - 4.7e-08 32.8 0.0 9.8e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 CDW57489.1 - 1.3e-06 28.1 0.1 0.077 12.8 0.0 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 CDW57489.1 - 0.00079 20.1 0.2 3.2 8.5 0.0 3.0 2 0 0 2 2 2 2 HlyD family secretion protein DUF2118 PF09891.9 CDW57489.1 - 0.0014 18.6 0.2 0.005 16.8 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2118) ATP-grasp_3 PF02655.14 CDW57489.1 - 0.011 15.7 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_4 PF13535.6 CDW57489.1 - 0.092 12.3 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain HlyD_D23 PF16576.5 CDW57489.1 - 0.15 11.2 0.1 5.1 6.2 0.0 2.4 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Glyco_tran_WecB PF03808.13 CDW57489.1 - 0.15 12.0 0.0 18 5.3 0.0 3.2 3 0 0 3 3 3 0 Glycosyl transferase WecB/TagA/CpsF family Carb_kinase PF01256.17 CDW57489.1 - 0.24 10.9 1.5 0.41 10.1 0.7 1.7 2 0 0 2 2 2 0 Carbohydrate kinase CBFD_NFYB_HMF PF00808.23 CDW57490.1 - 8.6e-06 25.9 0.2 0.018 15.3 0.1 2.8 3 0 0 3 3 3 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone UAA PF08449.11 CDW57491.1 - 1.6e-67 227.9 18.9 2.1e-67 227.5 18.9 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDW57491.1 - 0.00073 19.7 36.1 0.0024 18.1 15.9 4.2 3 2 1 4 4 4 2 EamA-like transporter family TPT PF03151.16 CDW57491.1 - 0.021 14.2 12.9 0.03 13.7 5.7 2.2 2 0 0 2 2 2 0 Triose-phosphate Transporter family JTB PF05439.12 CDW57491.1 - 0.28 11.2 3.2 9.9 6.2 0.1 2.9 2 0 0 2 2 2 0 Jumping translocation breakpoint protein (JTB) DUF5090 PF17009.5 CDW57491.1 - 3.7 7.5 11.0 12 5.7 11.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) Collagen PF01391.18 CDW57492.1 - 3e-17 62.1 67.8 1.7e-08 34.0 26.2 7.2 6 1 1 7 7 7 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW57492.1 - 1.7e-15 56.8 0.7 2.5e-15 56.3 0.7 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Prenyltrans PF00432.21 CDW57493.1 - 2.7e-44 148.6 20.5 2e-10 40.2 2.1 6.6 7 0 0 7 7 7 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 CDW57493.1 - 1.1e-08 34.6 0.2 5.7e-05 22.4 0.0 3.2 2 1 1 3 3 3 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 CDW57493.1 - 2.5e-07 30.1 0.0 0.009 15.1 0.0 3.4 1 1 2 3 3 3 3 Squalene-hopene cyclase N-terminal domain TED_complement PF07678.14 CDW57493.1 - 0.00056 19.0 0.1 2.8 6.9 0.0 3.6 3 1 0 4 4 4 2 A-macroglobulin TED domain EGF PF00008.27 CDW57494.1 - 4.7e-40 135.5 153.1 3.3e-07 30.5 9.2 10.7 10 0 0 10 10 10 10 EGF-like domain EGF_CA PF07645.15 CDW57494.1 - 2.2e-26 91.7 170.7 8.9e-09 35.4 10.0 10.6 4 2 6 10 10 10 8 Calcium-binding EGF domain hEGF PF12661.7 CDW57494.1 - 3.3e-18 65.6 136.3 0.00075 20.0 6.2 12.0 11 1 0 11 11 11 9 Human growth factor-like EGF EGF_2 PF07974.13 CDW57494.1 - 3.2e-15 56.2 176.8 0.0025 18.1 12.8 10.7 10 0 0 10 10 10 9 EGF-like domain FXa_inhibition PF14670.6 CDW57494.1 - 5e-09 36.3 138.9 0.024 14.9 7.6 10.7 6 3 4 10 10 10 8 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW57494.1 - 0.00014 22.0 162.9 0.0011 19.1 5.8 11.2 10 1 0 10 10 10 7 EGF domain Glyco_hydro_19 PF00182.19 CDW57495.1 - 2.6e-24 86.4 0.5 3.7e-24 85.9 0.5 1.2 1 0 0 1 1 1 1 Chitinase class I RAMP4 PF06624.12 CDW57496.1 - 1.6e-26 92.1 0.0 1.8e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 LSM PF01423.22 CDW57497.1 - 2.3e-19 68.8 0.0 2.6e-19 68.7 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDW57497.1 - 5.8e-06 26.4 0.0 6.8e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CDW57497.1 - 0.047 13.8 0.1 0.051 13.7 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain GATA PF00320.27 CDW57498.1 - 7.3e-19 67.1 15.2 3.4e-16 58.5 4.0 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 CDW57498.1 - 0.0039 16.7 7.6 0.012 15.1 0.8 2.3 2 0 0 2 2 2 1 TFIIB zinc-binding Vps36-NZF-N PF16988.5 CDW57498.1 - 0.0084 15.5 4.8 0.29 10.6 0.0 3.1 2 1 1 3 3 3 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF2387 PF09526.10 CDW57498.1 - 0.014 15.5 4.4 1.8 8.8 0.8 2.4 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) Cytochrom_CIII PF02085.16 CDW57498.1 - 0.019 15.3 2.7 0.031 14.6 2.7 1.3 1 0 0 1 1 1 0 Class III cytochrome C family A2L_zn_ribbon PF08792.10 CDW57498.1 - 0.24 11.1 11.9 8.4 6.2 0.1 3.9 4 0 0 4 4 4 0 A2L zinc ribbon domain Ta0938 PF11494.8 CDW57498.1 - 0.3 11.4 2.1 0.32 11.3 1.1 1.4 1 1 0 1 1 1 0 Ta0938 Zn-ribbon_8 PF09723.10 CDW57498.1 - 0.4 10.8 0.1 0.4 10.8 0.1 2.5 2 1 0 2 2 2 0 Zinc ribbon domain zf-piccolo PF05715.13 CDW57498.1 - 0.81 9.9 11.0 34 4.7 0.0 3.2 2 1 1 3 3 3 0 Piccolo Zn-finger eIF-5_eIF-2B PF01873.17 CDW57498.1 - 3.2 7.6 8.4 1.8 8.5 0.7 2.2 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Prim_Zn_Ribbon PF08273.12 CDW57498.1 - 3.6 7.9 7.6 6.2 7.2 1.1 2.5 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase Elf1 PF05129.13 CDW57498.1 - 5.1 7.2 11.2 2.1 8.5 0.2 2.6 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like DZR PF12773.7 CDW57498.1 - 6.5 6.9 14.1 15 5.7 3.0 3.0 1 1 1 2 2 2 0 Double zinc ribbon ENT PF03735.14 CDW57499.1 - 1.5e-09 37.8 0.0 4.5e-09 36.2 0.0 1.8 1 0 0 1 1 1 1 ENT domain His_Phos_1 PF00300.22 CDW57500.1 - 1.4e-14 54.2 0.0 6.2e-13 48.9 0.0 2.6 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) KH_1 PF00013.29 CDW57501.1 - 7.1e-70 230.8 11.7 2e-17 62.7 0.1 4.2 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.10 CDW57501.1 - 5.3e-20 70.6 1.1 5.3e-20 70.6 1.1 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF1897) KH_2 PF07650.17 CDW57501.1 - 3.8e-18 65.1 8.4 0.00017 21.3 0.0 4.5 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 CDW57501.1 - 1e-09 38.1 10.1 0.043 13.7 0.2 4.6 4 0 0 4 4 4 4 KH domain KH_5 PF13184.6 CDW57501.1 - 4.6e-05 23.4 5.2 3.1 8.0 0.1 4.4 4 0 0 4 4 4 2 NusA-like KH domain Secretin_N PF03958.17 CDW57501.1 - 0.045 14.2 2.6 76 3.8 0.0 4.9 6 0 0 6 6 6 0 Bacterial type II/III secretion system short domain DUF2570 PF10828.8 CDW57501.1 - 8.9 6.2 9.0 40 4.1 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) SAM_2 PF07647.17 CDW57502.1 - 0.003 17.6 0.1 0.0092 16.1 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Gpr1_Fun34_YaaH PF01184.19 CDW57503.1 - 8.9e-26 90.8 15.5 1.2e-25 90.4 15.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Collagen PF01391.18 CDW57504.1 - 0.00076 19.2 21.1 0.00076 19.2 21.1 4.3 4 1 1 5 5 5 2 Collagen triple helix repeat (20 copies) Pkinase PF00069.25 CDW57505.1 - 4.6e-39 134.4 0.0 1.9e-37 129.1 0.0 2.7 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57505.1 - 4.3e-36 124.5 0.0 1.9e-32 112.6 0.0 2.3 1 1 0 2 2 2 2 Protein tyrosine kinase LRR_8 PF13855.6 CDW57505.1 - 1e-28 98.9 30.6 2.8e-10 39.8 0.5 6.3 5 1 1 6 6 6 5 Leucine rich repeat Ank_2 PF12796.7 CDW57505.1 - 4.2e-24 84.9 0.0 4e-09 37.0 0.0 4.3 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Roc PF08477.13 CDW57505.1 - 1.4e-21 76.9 0.1 3.2e-17 62.9 0.0 2.5 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 CDW57505.1 - 3.8e-20 72.5 0.0 1e-19 71.1 0.0 1.7 1 1 0 1 1 1 1 C-terminal of Roc, COR, domain Ank_3 PF13606.6 CDW57505.1 - 2.6e-17 61.1 4.5 0.00011 22.4 0.1 6.0 5 0 0 5 5 5 3 Ankyrin repeat LRR_4 PF12799.7 CDW57505.1 - 5.4e-17 61.6 39.2 0.0001 22.6 1.9 8.4 6 3 2 8 8 8 6 Leucine Rich repeats (2 copies) Ank_5 PF13857.6 CDW57505.1 - 9.7e-15 54.4 4.3 7.1e-05 23.0 0.1 5.5 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW57505.1 - 1.1e-14 54.6 6.9 1.6e-05 25.4 0.1 5.2 5 1 1 6 6 4 3 Ankyrin repeats (many copies) Ank PF00023.30 CDW57505.1 - 2.7e-14 52.8 10.1 3.1e-05 24.2 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat Ras PF00071.22 CDW57505.1 - 1e-09 38.2 0.0 2.5e-07 30.5 0.0 2.6 1 1 1 2 2 2 1 Ras family LRR_1 PF00560.33 CDW57505.1 - 0.021 15.3 27.7 26 5.9 0.0 10.7 11 0 0 11 11 11 0 Leucine Rich Repeat Arf PF00025.21 CDW57505.1 - 0.022 14.2 0.1 5.6 6.4 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_28 PF13521.6 CDW57505.1 - 0.056 13.7 0.2 0.23 11.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDW57505.1 - 0.099 13.0 0.0 0.33 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain YrbL-PhoP_reg PF10707.9 CDW57505.1 - 0.1 12.1 0.0 1.2 8.6 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Calreticulin PF00262.18 CDW57506.1 - 7.5e-55 186.3 0.3 1.8e-44 152.1 0.0 2.3 2 0 0 2 2 2 2 Calreticulin family Proteasome PF00227.26 CDW57507.1 - 3.1e-57 193.2 0.4 3.6e-57 192.9 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit HSP20 PF00011.21 CDW57508.1 - 6.7e-27 93.6 0.8 8.5e-27 93.3 0.8 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW57508.1 - 0.0037 16.8 0.0 0.0058 16.2 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA EMP24_GP25L PF01105.24 CDW57510.1 - 2.5e-39 135.1 0.1 2.9e-39 134.9 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2846 PF11008.8 CDW57510.1 - 0.035 14.1 0.0 0.084 12.9 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2846) DUF2207 PF09972.9 CDW57511.1 - 0.00017 20.5 0.3 0.24 10.1 0.0 2.2 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) DUF1676 PF07898.13 CDW57511.1 - 0.016 15.3 0.0 0.095 12.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) FtsX PF02687.21 CDW57511.1 - 0.19 12.2 17.3 2.1 8.8 6.0 2.3 2 0 0 2 2 2 0 FtsX-like permease family SET PF00856.28 CDW57512.1 - 1.1e-20 74.6 1.0 6.8e-20 72.1 1.0 2.1 1 1 0 1 1 1 1 SET domain AUDH_Cupin PF18637.1 CDW57512.1 - 0.087 12.8 0.3 0.16 12.0 0.0 1.5 2 0 0 2 2 2 0 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain Trypsin PF00089.26 CDW57513.1 - 3.4e-08 33.6 0.0 7.8e-08 32.4 0.0 1.6 1 1 0 1 1 1 1 Trypsin DDE_1 PF03184.19 CDW57513.1 - 7.4e-06 25.7 0.3 1.5e-05 24.7 0.3 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Trypsin PF00089.26 CDW57514.1 - 3.9e-21 75.9 0.0 7.4e-11 42.3 0.0 2.8 2 2 0 2 2 2 2 Trypsin Motile_Sperm PF00635.26 CDW57515.1 - 4.1e-16 58.8 0.0 4.7e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CLASP_N PF12348.8 CDW57516.1 - 5.4e-43 147.2 7.7 7.2e-36 123.9 0.4 4.3 5 0 0 5 5 5 2 CLASP N terminal HEAT PF02985.22 CDW57516.1 - 2.3e-11 42.9 16.1 0.034 14.4 0.2 9.6 11 0 0 11 11 11 4 HEAT repeat Cnd1 PF12717.7 CDW57516.1 - 3.5e-07 30.4 5.1 0.79 9.7 0.0 6.5 6 2 1 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDW57516.1 - 5e-07 30.2 1.5 1.8 9.2 0.0 6.0 5 2 1 6 6 6 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 CDW57516.1 - 2.1e-06 28.0 9.8 0.023 15.0 0.0 7.1 6 2 2 8 8 8 1 HEAT repeats TIP120 PF08623.10 CDW57516.1 - 0.0074 16.1 0.0 0.72 9.6 0.0 3.6 4 0 0 4 4 4 1 TATA-binding protein interacting (TIP20) UNC45-central PF11701.8 CDW57516.1 - 0.92 9.5 3.7 39 4.2 0.0 4.3 3 2 1 4 4 4 0 Myosin-binding striated muscle assembly central RasGEF_N_2 PF14663.6 CDW57516.1 - 2.3 8.6 6.9 6 7.3 0.0 4.6 5 1 0 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain E1-E2_ATPase PF00122.20 CDW57517.1 - 0.0059 16.1 0.0 0.02 14.4 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase PI-PLC-X PF00388.19 CDW57517.1 - 0.0084 15.7 0.0 0.065 12.8 0.0 2.2 3 0 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, X domain COQ7 PF03232.13 CDW57518.1 - 2.3e-56 190.2 0.1 2.9e-56 189.9 0.1 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Dpy19 PF10034.9 CDW57519.1 - 1.2e-182 608.6 18.9 1.3e-182 608.4 18.9 1.0 1 0 0 1 1 1 1 Q-cell neuroblast polarisation Med18 PF09637.10 CDW57520.1 - 1.8e-24 87.0 0.0 5.7e-18 65.7 0.0 2.0 1 1 1 2 2 2 2 Med18 protein Patatin PF01734.22 CDW57522.1 - 1.3e-13 51.6 6.6 1.6e-12 48.1 4.9 3.0 2 1 0 2 2 2 1 Patatin-like phospholipase RHH_6 PF16762.5 CDW57522.1 - 0.18 12.5 0.0 44 4.8 0.0 2.8 3 0 0 3 3 3 0 Ribbon-helix-helix domain FtsJ PF01728.19 CDW57523.1 - 1e-32 113.6 0.0 1.5e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 CDW57523.1 - 9.4e-14 51.0 4.1 1.7e-13 50.2 4.1 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CDW57523.1 - 0.0025 17.9 2.0 0.0058 16.7 2.0 1.6 1 0 0 1 1 1 1 G-patch domain DUF4837 PF16125.5 CDW57524.1 - 0.005 15.9 0.5 0.006 15.7 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4837) NTP_transf_2 PF01909.23 CDW57524.1 - 0.015 15.6 0.1 0.11 12.8 0.1 2.0 1 1 1 2 2 2 0 Nucleotidyltransferase domain KORA PF16509.5 CDW57524.1 - 0.055 13.7 0.1 0.098 12.9 0.1 1.4 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor UL21a PF17636.2 CDW57524.1 - 0.16 12.0 1.8 0.18 11.8 1.8 1.1 1 0 0 1 1 1 0 Viral Unique Long protein 21a Pkinase PF00069.25 CDW57525.1 - 3.3e-24 85.7 0.1 3.9e-24 85.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57525.1 - 2.6e-13 49.8 0.0 3.1e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW57525.1 - 0.026 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 CDW57525.1 - 0.04 13.5 0.1 12 5.4 0.0 2.6 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CDW57525.1 - 0.044 13.1 0.0 0.098 12.0 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW57525.1 - 0.065 12.0 0.0 0.087 11.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 CDW57525.1 - 0.08 12.2 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 0 Kinase-like RRM_1 PF00076.22 CDW57526.1 - 3.2e-10 39.7 0.0 0.00035 20.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 CDW57526.1 - 0.073 13.0 0.0 0.21 11.6 0.0 1.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif S-AdoMet_synt_C PF02773.16 CDW57527.1 - 5e-61 204.7 0.0 8.7e-61 203.9 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDW57527.1 - 3.6e-40 137.0 0.0 5.4e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CDW57527.1 - 1e-34 119.2 0.0 2.1e-34 118.1 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 CDW57527.1 - 0.13 11.1 0.0 0.25 10.1 0.0 1.4 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) RCC1 PF00415.18 CDW57529.1 - 7.3e-65 215.4 25.2 2.2e-12 47.4 0.2 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDW57529.1 - 2.9e-29 100.2 52.8 5.5e-06 26.0 0.8 7.6 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat MliC PF09864.9 CDW57529.1 - 0.069 13.1 0.1 2 8.4 0.0 2.8 3 0 0 3 3 3 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme LolA_2 PF16584.5 CDW57529.1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA DUF4213 PF13938.6 CDW57529.1 - 3.6 7.9 5.9 5.8 7.2 0.0 3.6 4 2 1 5 5 5 0 Putative heavy-metal chelation RFC1 PF08519.12 CDW57530.1 - 3.4e-48 163.8 0.2 1e-47 162.2 0.2 1.9 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 CDW57530.1 - 1e-12 48.6 0.0 5.5e-12 46.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 CDW57530.1 - 6.8e-12 45.6 0.0 1.9e-11 44.1 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 CDW57530.1 - 0.00019 21.4 0.6 0.0024 17.8 0.5 2.3 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 CDW57530.1 - 0.00033 21.0 3.1 0.013 15.8 0.1 3.7 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CDW57530.1 - 0.0011 19.4 0.0 0.004 17.6 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CDW57530.1 - 0.0032 17.2 0.0 0.011 15.5 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 CDW57530.1 - 0.0038 17.0 0.0 0.0098 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 CDW57530.1 - 0.008 16.5 0.1 0.022 15.1 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 CDW57530.1 - 0.016 15.2 0.0 0.087 12.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDW57530.1 - 0.017 15.1 0.0 0.054 13.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 CDW57530.1 - 0.033 14.6 1.0 1 9.8 0.0 3.1 3 1 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 CDW57530.1 - 0.059 13.5 0.0 0.16 12.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.13 CDW57530.1 - 0.084 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase III, delta subunit NACHT PF05729.12 CDW57530.1 - 0.11 12.4 0.0 0.98 9.3 0.0 2.3 1 1 0 1 1 1 0 NACHT domain DprA_WH PF17782.1 CDW57530.1 - 0.12 12.5 0.1 0.34 11.0 0.1 1.7 1 0 0 1 1 1 0 DprA winged helix domain LIM PF00412.22 CDW57531.1 - 5.1e-23 81.1 30.4 1.8e-11 44.1 15.5 2.8 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 CDW57531.1 - 1.2e-17 63.5 5.8 3.1e-17 62.2 5.8 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW57531.1 - 0.00052 19.9 0.1 0.00052 19.9 0.1 2.3 3 0 0 3 3 3 1 Homeobox KN domain Homez PF11569.8 CDW57531.1 - 0.02 14.3 0.1 0.043 13.3 0.1 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Suv3_N PF18114.1 CDW57531.1 - 0.13 12.4 0.1 0.28 11.3 0.1 1.5 1 0 0 1 1 1 0 Suv3 helical N-terminal domain SSF PF00474.17 CDW57532.1 - 1.2e-32 113.3 25.8 2.7e-32 112.2 25.8 1.6 1 1 0 1 1 1 1 Sodium:solute symporter family AcrZ PF10766.9 CDW57532.1 - 7.9 6.1 8.9 6.2 6.5 5.7 2.5 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ zf-MIZ PF02891.20 CDW57533.1 - 1.3e-18 66.4 7.1 1.3e-18 66.4 7.1 2.4 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CDW57533.1 - 0.0021 17.8 3.5 0.0021 17.8 3.5 2.3 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.29 CDW57533.1 - 0.1 12.5 5.2 0.072 13.0 2.5 2.1 2 0 0 2 2 2 0 PHD-finger Tetraspanin PF00335.20 CDW57534.1 - 6.7e-40 137.2 16.9 8.5e-40 136.9 16.9 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF4692 PF15763.5 CDW57534.1 - 0.00032 21.2 0.6 0.00056 20.4 0.0 1.6 2 0 0 2 2 2 1 Regulator of human erythroid cell expansion (RHEX) MgtE PF01769.16 CDW57534.1 - 6 7.3 9.1 1.9 8.9 4.3 2.2 2 1 0 2 2 2 0 Divalent cation transporter zf-C2H2 PF00096.26 CDW57535.1 - 9.9e-11 41.5 17.6 0.0039 17.5 2.3 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW57535.1 - 4.7e-10 39.4 19.4 0.0012 19.4 0.5 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW57535.1 - 0.00049 20.4 17.9 0.12 12.9 0.3 5.2 6 1 0 6 6 5 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CDW57535.1 - 0.00054 20.2 7.0 0.0049 17.1 0.0 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 CDW57535.1 - 0.0012 19.1 10.4 0.52 10.6 0.1 3.8 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 CDW57535.1 - 0.041 14.3 13.1 1.3 9.6 0.5 3.3 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger PyrI_C PF02748.15 CDW57535.1 - 0.056 13.4 0.2 0.26 11.2 0.0 2.2 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn-C2H2_12 PF18112.1 CDW57535.1 - 0.073 13.5 1.2 0.073 13.5 1.2 2.6 3 0 0 3 3 2 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 CDW57535.1 - 0.28 11.6 10.4 6.5 7.1 0.1 3.2 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 CDW57535.1 - 0.3 11.5 5.8 1.3 9.5 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-AN1 PF01428.16 CDW57535.1 - 1.1 9.5 6.4 7 6.9 0.4 3.5 3 0 0 3 3 3 0 AN1-like Zinc finger LIM PF00412.22 CDW57535.1 - 1.9 8.7 6.9 0.87 9.9 0.3 2.6 3 0 0 3 3 3 0 LIM domain zf-C2H2_8 PF15909.5 CDW57535.1 - 6.9 7.0 10.3 3 8.2 0.3 3.1 2 1 1 3 3 3 0 C2H2-type zinc ribbon pPIWI_RE_REase PF18154.1 CDW57536.1 - 0.02 14.9 0.3 0.045 13.7 0.3 1.6 1 0 0 1 1 1 0 REase associating with pPIWI_RE Autophagy_N PF03986.13 CDW57537.1 - 3.8e-38 130.5 0.1 7.8e-31 106.8 0.0 2.3 2 0 0 2 2 2 2 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 CDW57537.1 - 2.9e-20 72.6 0.4 8.4e-20 71.1 0.4 1.8 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 CDW57537.1 - 5.3e-15 54.6 1.0 1.1e-14 53.6 1.0 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal TTR-52 PF01060.23 CDW57538.1 - 2.6e-13 50.5 0.0 3.4e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family DEC1 PF15859.5 CDW57538.1 - 0.035 14.1 0.0 0.052 13.6 0.0 1.2 1 0 0 1 1 1 0 Deleted in esophageal cancer 1 family Sulfotransfer_2 PF03567.14 CDW57539.1 - 7.6e-28 98.1 0.3 9.8e-28 97.7 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase family Gal-3-0_sulfotr PF06990.11 CDW57539.1 - 0.00024 20.1 0.0 0.00038 19.5 0.0 1.3 1 0 0 1 1 1 1 Galactose-3-O-sulfotransferase Sulfotransfer_1 PF00685.27 CDW57539.1 - 0.0039 16.7 0.2 0.0066 16.0 0.2 1.4 1 1 0 1 1 1 1 Sulfotransferase domain zf-C2H2 PF00096.26 CDW57541.1 - 5.6e-07 29.7 18.6 7.4e-05 23.0 4.2 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW57541.1 - 2.6e-06 27.8 18.8 0.018 15.9 4.1 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW57541.1 - 3.2e-05 24.1 18.7 0.0015 18.9 0.4 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 CDW57541.1 - 0.00042 20.6 15.8 0.0015 18.8 0.5 3.5 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW57541.1 - 0.0043 17.3 0.9 0.0043 17.3 0.9 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding Flu_M1 PF00598.19 CDW57541.1 - 0.0087 15.6 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Influenza Matrix protein (M1) zf-CCHC_2 PF13696.6 CDW57541.1 - 0.024 14.5 8.6 1.3 8.9 0.9 3.3 3 0 0 3 3 3 0 Zinc knuckle zf-C2H2_6 PF13912.6 CDW57541.1 - 0.056 13.4 14.2 0.67 10.0 2.2 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger DUF2321 PF10083.9 CDW57541.1 - 0.065 12.9 4.6 0.17 11.5 0.9 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-C2H2_8 PF15909.5 CDW57541.1 - 0.13 12.6 7.5 0.098 13.0 1.5 2.2 1 1 1 2 2 2 0 C2H2-type zinc ribbon Actin_micro PF17003.5 CDW57541.1 - 0.59 9.2 4.6 2.4 7.2 4.6 2.0 1 1 0 1 1 1 0 Putative actin-like family zf-C2H2_3 PF13878.6 CDW57541.1 - 0.92 9.4 0.1 0.92 9.4 0.1 2.9 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO zf-trcl PF13451.6 CDW57541.1 - 0.98 9.4 0.1 0.98 9.4 0.1 3.4 3 1 1 4 4 4 0 Probable zinc-ribbon domain zf-C2H2_2 PF12756.7 CDW57541.1 - 2.9 8.3 8.9 0.94 9.8 0.5 2.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 CDW57541.1 - 6.1 6.7 14.8 0.87 9.4 0.6 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type p450 PF00067.22 CDW57542.1 - 8e-82 275.4 0.7 1.8e-58 198.4 0.1 2.1 1 1 1 2 2 2 2 Cytochrome P450 dNK PF01712.19 CDW57542.1 - 0.02 14.7 0.2 0.46 10.3 0.0 2.4 2 0 0 2 2 2 0 Deoxynucleoside kinase Trypsin PF00089.26 CDW57543.1 - 5.9e-46 157.1 0.1 7.1e-46 156.8 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW57543.1 - 5.2e-07 30.7 0.0 9.8e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW57543.1 - 0.067 13.6 0.0 0.11 12.9 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1986) Myb_DNA-binding PF00249.31 CDW57544.1 - 1.4e-10 41.2 0.1 2e-05 24.7 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CDW57544.1 - 0.0038 17.4 1.4 1.1 9.6 0.2 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain PRKCSH-like PF12999.7 CDW57545.1 - 6.6e-38 130.3 7.1 6.6e-38 130.3 7.1 1.7 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 CDW57545.1 - 1.4e-21 76.8 0.2 1.4e-20 73.6 0.0 2.1 1 1 1 2 2 2 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.18 CDW57545.1 - 2.6e-06 27.5 12.2 0.00067 19.8 2.1 3.0 2 1 0 2 2 2 2 Low-density lipoprotein receptor domain class A Astacin PF01400.24 CDW57546.1 - 2.2e-46 157.9 0.0 3.4e-46 157.3 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 CDW57546.1 - 0.00035 20.4 0.8 0.35 10.7 1.3 3.1 2 1 1 3 3 3 2 Matrixin PH PF00169.29 CDW57547.1 - 5.8e-07 30.0 0.5 1.4e-05 25.5 0.2 2.6 2 0 0 2 2 2 1 PH domain Hfx_Cass5 PF18287.1 CDW57547.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Integron Cassette Protein Hfx_Cass5 Metalloenzyme PF01676.18 CDW57548.1 - 6.6e-80 268.0 0.2 7.7e-80 267.8 0.2 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 CDW57548.1 - 3.9e-70 235.7 0.3 1.9e-69 233.4 0.3 1.9 1 1 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Sulfatase PF00884.23 CDW57548.1 - 0.00037 20.0 0.0 0.0021 17.5 0.0 2.1 1 1 0 1 1 1 1 Sulfatase PglZ PF08665.12 CDW57548.1 - 0.00077 19.6 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 PglZ domain Phosphodiest PF01663.22 CDW57548.1 - 0.0017 18.0 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase HSP20 PF00011.21 CDW57549.1 - 1.1e-17 64.1 0.3 2e-17 63.2 0.0 1.5 2 0 0 2 2 2 1 Hsp20/alpha crystallin family STI1 PF17830.1 CDW57550.1 - 5.6e-10 39.0 1.2 9.5e-10 38.3 1.2 1.4 1 0 0 1 1 1 1 STI1 domain ATP-synt_E PF05680.12 CDW57550.1 - 0.034 14.5 1.4 0.062 13.6 1.4 1.4 1 0 0 1 1 1 0 ATP synthase E chain NARP1 PF12569.8 CDW57550.1 - 0.058 12.3 4.4 0.077 11.9 4.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 tRNA_U5-meth_tr PF05958.11 CDW57551.1 - 1.8e-13 50.2 0.0 4.1e-13 49.0 0.0 1.6 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 CDW57551.1 - 1.1e-09 38.9 0.0 2.3e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW57551.1 - 1.8e-09 37.6 0.1 2.8e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW57551.1 - 1e-07 31.7 0.0 1.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 CDW57551.1 - 8.9e-06 26.3 0.0 1.9e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 CDW57551.1 - 1.5e-05 24.7 0.1 2.6e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 CDW57551.1 - 2.7e-05 24.2 0.1 5.1e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CDW57551.1 - 0.00013 21.5 0.1 0.0002 20.9 0.1 1.3 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.18 CDW57551.1 - 0.00055 19.3 0.1 0.0011 18.3 0.1 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 CDW57551.1 - 0.00084 18.8 0.1 0.0013 18.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 CDW57551.1 - 0.0028 18.4 0.0 0.0052 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDW57551.1 - 0.0052 16.5 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 TPMT PF05724.11 CDW57551.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_18 PF12847.7 CDW57551.1 - 0.013 15.4 0.1 0.026 14.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.18 CDW57551.1 - 0.014 15.2 0.0 0.035 13.8 0.0 1.7 1 0 0 1 1 1 0 DNA methylase Methyltransf_23 PF13489.6 CDW57551.1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 CDW57551.1 - 0.027 14.1 0.6 0.31 10.7 0.6 2.2 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 RRM_1 PF00076.22 CDW57551.1 - 0.066 13.0 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PCMT PF01135.19 CDW57551.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Histone PF00125.24 CDW57552.1 - 6.2e-17 62.2 0.7 7.5e-17 61.9 0.7 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW57552.1 - 4.1e-05 23.8 0.0 7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 CDW57552.1 - 0.018 15.3 0.1 0.025 14.8 0.1 1.1 1 0 0 1 1 1 0 CENP-W protein TAF PF02969.17 CDW57552.1 - 0.031 14.5 0.1 0.055 13.6 0.1 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) zf-H2C2_2 PF13465.6 CDW57553.1 - 9.3e-19 66.9 24.5 6.6e-09 35.8 2.0 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 CDW57553.1 - 2.8e-18 65.2 32.7 2.6e-06 27.6 2.9 5.5 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW57553.1 - 3.2e-13 49.3 27.1 0.0024 18.6 1.9 4.9 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW57553.1 - 4.7e-05 23.3 20.5 0.073 13.1 0.6 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-Di19 PF05605.12 CDW57553.1 - 0.00052 20.3 12.9 0.15 12.3 4.1 3.2 2 1 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 CDW57553.1 - 0.0018 18.0 0.1 0.0018 18.0 0.1 4.0 4 0 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 CDW57553.1 - 0.059 14.0 4.5 0.15 12.7 4.5 1.7 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zinc_ribbon_15 PF17032.5 CDW57553.1 - 0.12 13.1 5.6 5.8 7.7 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon family zf-C2H2_2 PF12756.7 CDW57553.1 - 0.13 12.6 17.1 1.5 9.2 1.3 3.9 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 CDW57553.1 - 0.16 11.8 2.5 11 5.9 0.2 2.8 2 0 0 2 2 2 0 GAGA factor DUF2225 PF09986.9 CDW57553.1 - 0.19 11.4 4.6 0.4 10.4 1.7 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) C1_4 PF07975.12 CDW57553.1 - 0.29 11.4 8.3 2.1 8.6 1.5 3.0 2 1 1 3 3 3 0 TFIIH C1-like domain Zf_RING PF16744.5 CDW57553.1 - 0.31 11.2 10.4 0.33 11.1 3.2 3.4 1 1 3 4 4 4 0 KIAA1045 RING finger zf_UBZ PF18439.1 CDW57553.1 - 1.6 8.4 5.3 15 5.3 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2_9 PF16293.5 CDW57553.1 - 5.3 7.0 9.3 1.4 8.8 0.1 3.5 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) FYVE PF01363.21 CDW57553.1 - 5.9 7.1 16.8 0.56 10.4 8.0 2.6 1 1 1 2 2 2 0 FYVE zinc finger zf-BED PF02892.15 CDW57553.1 - 6.6 6.9 19.4 1.7 8.7 0.4 3.9 3 1 0 3 3 3 0 BED zinc finger zf-RING_2 PF13639.6 CDW57553.1 - 7 7.1 10.1 97 3.4 8.3 2.9 2 1 0 2 2 2 0 Ring finger domain Zn-ribbon_8 PF09723.10 CDW57553.1 - 8.2 6.6 10.9 2.6 8.3 1.3 3.1 2 1 1 3 3 3 0 Zinc ribbon domain DUF2000 PF09391.10 CDW57555.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2000) Ribosomal_L11 PF00298.19 CDW57556.1 - 6.2e-21 74.7 0.0 1.3e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 CDW57556.1 - 5.6e-20 70.9 0.1 9.7e-20 70.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain RRS1 PF04939.12 CDW57558.1 - 2.4e-52 177.1 4.0 2.4e-52 177.1 4.0 2.4 3 1 0 3 3 3 1 Ribosome biogenesis regulatory protein (RRS1) Acyltransferase PF01553.21 CDW57559.1 - 2.7e-07 30.3 0.0 9.6e-06 25.2 0.0 2.4 1 1 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CDW57559.1 - 0.0042 17.2 0.4 0.039 14.0 0.1 2.5 3 0 0 3 3 3 1 Acyltransferase C-terminus SepF PF04472.12 CDW57559.1 - 0.018 15.3 0.0 0.049 13.9 0.0 1.7 2 0 0 2 2 2 0 Cell division protein SepF WD40 PF00400.32 CDW57560.1 - 7.5e-39 131.0 11.7 1.3e-07 32.2 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57560.1 - 2.9e-09 37.1 0.0 0.013 15.8 0.0 5.6 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 CDW57560.1 - 0.00084 18.2 0.0 0.69 8.6 0.0 3.4 2 1 1 4 4 4 2 Nup133 N terminal like Nup160 PF11715.8 CDW57560.1 - 0.0019 16.9 0.1 0.54 8.8 0.0 2.9 3 0 0 3 3 3 2 Nucleoporin Nup120/160 sCache_3_2 PF17203.4 CDW57560.1 - 0.2 11.8 0.0 0.46 10.6 0.0 1.5 1 0 0 1 1 1 0 Single cache domain 3 zf-ribbon_3 PF13248.6 CDW57561.1 - 0.015 14.6 2.3 0.58 9.7 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 CDW57561.1 - 0.075 13.1 3.3 0.15 12.1 3.3 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Dynamin_N PF00350.23 CDW57562.1 - 7.5e-13 48.9 0.0 1.3e-05 25.3 0.0 2.6 1 1 1 2 2 2 2 Dynamin family DUF5600 PF18150.1 CDW57562.1 - 1.1e-11 45.3 0.1 2.5e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) MMR_HSR1 PF01926.23 CDW57562.1 - 3e-08 33.7 0.0 8.1e-08 32.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_4 PF12763.7 CDW57562.1 - 1.9e-06 27.7 0.0 4.2e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand AIG1 PF04548.16 CDW57562.1 - 1.1e-05 24.8 0.0 0.021 14.1 0.0 2.3 2 0 0 2 2 2 2 AIG1 family EHD_N PF16880.5 CDW57562.1 - 5.6e-05 22.9 2.0 0.00012 21.9 1.6 1.8 2 0 0 2 2 2 1 N-terminal EH-domain containing protein RsgA_GTPase PF03193.16 CDW57562.1 - 0.0005 20.0 0.5 0.18 11.7 0.0 3.3 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 CDW57562.1 - 0.00057 19.5 0.0 0.082 12.4 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EF-hand_1 PF00036.32 CDW57562.1 - 0.0017 17.7 0.2 0.004 16.6 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 CDW57562.1 - 0.0021 18.4 0.0 0.0057 17.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair FeoB_N PF02421.18 CDW57562.1 - 0.018 14.6 0.4 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B Roc PF08477.13 CDW57562.1 - 0.02 15.1 0.1 0.77 10.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 CDW57562.1 - 0.033 13.9 0.1 20 4.9 0.0 3.1 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation EF-hand_8 PF13833.6 CDW57562.1 - 0.072 13.0 0.1 0.21 11.4 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 CDW57562.1 - 0.13 12.3 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain RhoGEF PF00621.20 CDW57563.1 - 1.5e-25 90.5 3.9 1.9e-25 90.2 2.8 1.7 1 1 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 CDW57563.1 - 1.5e-05 24.9 0.0 3.2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 CDW57563.1 - 4.4e-05 23.3 0.7 0.00019 21.3 0.0 2.4 2 1 0 2 2 2 1 PH domain IQ_SEC7_PH PF16453.5 CDW57563.1 - 0.024 14.6 0.0 0.078 13.0 0.0 1.8 1 0 0 1 1 1 0 PH domain DUF4904 PF16247.5 CDW57563.1 - 0.13 12.1 0.0 0.31 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4904) Hist_deacetyl PF00850.19 CDW57564.1 - 1.8e-46 159.1 0.0 2.3e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DUF1256 PF06866.11 CDW57564.1 - 0.051 13.0 0.0 0.095 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1256) Motile_Sperm PF00635.26 CDW57565.1 - 8e-15 54.6 0.0 1.2e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Pyr_redox_2 PF07992.14 CDW57566.1 - 2.5e-25 89.3 0.3 4.9e-24 85.1 0.3 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 CDW57566.1 - 3.2e-08 33.4 0.2 2e-05 24.4 0.0 2.8 2 0 0 2 2 2 2 Rubredoxin NAD+ reductase C-terminal domain K_oxygenase PF13434.6 CDW57566.1 - 7.2e-05 22.1 0.3 0.00078 18.7 0.1 2.1 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CDW57566.1 - 0.0037 16.6 0.7 1.4 8.1 0.0 3.7 3 2 1 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDW57566.1 - 0.053 14.1 2.0 1.9 9.1 0.1 3.1 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CDW57566.1 - 0.063 13.3 0.2 36 4.3 0.0 3.2 3 0 0 3 3 3 0 FAD-NAD(P)-binding OST3_OST6 PF04756.13 CDW57567.1 - 1.2e-77 261.1 0.0 1.7e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF1129 PF06570.11 CDW57567.1 - 0.015 14.8 2.3 0.015 14.8 2.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) TF_Zn_Ribbon PF08271.12 CDW57567.1 - 0.09 12.3 0.0 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding Calsequestrin PF01216.17 CDW57567.1 - 0.2 10.6 0.0 0.27 10.2 0.0 1.1 1 0 0 1 1 1 0 Calsequestrin E1-E2_ATPase PF00122.20 CDW57567.1 - 0.82 9.2 2.4 2 7.9 0.0 2.2 2 0 0 2 2 2 0 E1-E2 ATPase Galactosyl_T PF01762.21 CDW57568.1 - 6.3e-52 176.2 1.2 8.8e-52 175.8 1.2 1.2 1 0 0 1 1 1 1 Galactosyltransferase DUF3960 PF13142.6 CDW57568.1 - 0.089 12.9 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3960) Q_salvage PF10343.9 CDW57570.1 - 9.5e-19 68.0 5.2 1.1e-14 54.7 0.0 2.9 1 1 2 3 3 3 2 Potential Queuosine, Q, salvage protein family DUF4853 PF16145.5 CDW57570.1 - 0.15 12.1 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) PH PF00169.29 CDW57571.1 - 9.2e-11 42.2 0.2 1.8e-10 41.3 0.2 1.5 1 0 0 1 1 1 1 PH domain RA PF00788.23 CDW57571.1 - 1.3e-05 25.7 0.1 5.2e-05 23.8 0.1 2.1 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_11 PF15413.6 CDW57571.1 - 0.003 18.0 0.3 0.0076 16.7 0.3 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain KaiA PF07688.12 CDW57571.1 - 0.16 12.2 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 KaiA C-terminal domain Motile_Sperm PF00635.26 CDW57572.1 - 1.6e-09 37.6 0.0 1.9e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Edc3_linker PF16598.5 CDW57572.1 - 0.13 12.9 0.0 0.16 12.6 0.0 1.3 1 0 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 DUF3666 PF12408.8 CDW57572.1 - 0.21 10.8 0.7 1.1 8.5 0.2 2.2 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase DUF5478 PF17572.2 CDW57573.1 - 0.03 14.4 0.1 0.068 13.3 0.0 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5478) SAICAR_synt PF01259.18 CDW57574.1 - 1.1e-50 172.6 0.0 1.5e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase AIRC PF00731.20 CDW57574.1 - 4.7e-37 126.8 0.0 7.8e-37 126.1 0.0 1.3 1 0 0 1 1 1 1 AIR carboxylase DUF667 PF05018.13 CDW57576.1 - 1.2e-77 259.8 0.0 1.4e-77 259.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Ribosomal_L7Ae PF01248.26 CDW57577.1 - 2.1e-28 97.9 0.1 2.7e-28 97.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 CDW57577.1 - 0.00027 20.8 0.0 0.00041 20.2 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 CDW57577.1 - 0.0048 17.0 0.1 0.0056 16.7 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 baeRF_family10 PF18854.1 CDW57577.1 - 0.14 12.4 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 Transket_pyr PF02779.24 CDW57578.1 - 4.6e-40 137.2 0.0 8.5e-40 136.3 0.0 1.4 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CDW57578.1 - 9.7e-26 90.1 0.0 2e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain NTP_transf_7 PF07984.12 CDW57579.1 - 2.5e-128 427.8 0.3 2.9e-128 427.6 0.3 1.0 1 0 0 1 1 1 1 Nucleotidyltransferase AAA_lid_7 PF17867.1 CDW57579.1 - 0.041 14.1 0.1 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 Midasin AAA lid domain PHO4 PF01384.20 CDW57580.1 - 2.1e-59 201.3 6.6 2.5e-59 201.0 6.6 1.0 1 0 0 1 1 1 1 Phosphate transporter family MerT PF02411.15 CDW57580.1 - 0.032 14.3 0.6 0.053 13.5 0.6 1.5 1 0 0 1 1 1 0 MerT mercuric transport protein EF-hand_7 PF13499.6 CDW57581.1 - 2.7e-22 79.0 2.5 3.1e-08 34.0 0.1 4.1 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 CDW57581.1 - 1.1e-21 74.7 11.6 1.9e-05 23.8 0.1 5.8 5 1 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 CDW57581.1 - 2.3e-21 73.8 4.7 1.8e-05 24.3 0.1 5.3 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 CDW57581.1 - 1.7e-18 66.2 7.8 0.0017 18.2 0.5 5.8 5 1 1 6 6 6 6 EF-hand domain pair EF-hand_5 PF13202.6 CDW57581.1 - 1e-17 62.7 6.3 0.00019 20.8 0.1 4.6 4 1 0 4 4 4 3 EF hand Caleosin PF05042.13 CDW57581.1 - 0.06 13.3 2.2 8.7 6.2 0.0 3.7 3 1 1 4 4 4 0 Caleosin related protein EF-hand_10 PF14788.6 CDW57581.1 - 0.094 12.6 1.2 58 3.7 0.0 3.5 4 0 0 4 4 4 0 EF hand Dockerin_1 PF00404.18 CDW57581.1 - 0.17 12.1 0.6 5.4 7.3 0.0 2.7 2 1 1 3 3 3 0 Dockerin type I domain LIM PF00412.22 CDW57582.1 - 4.9e-16 58.7 46.8 3e-08 33.7 10.2 4.2 4 0 0 4 4 4 3 LIM domain DUF1974 PF09317.11 CDW57582.1 - 0.025 14.2 0.0 0.26 10.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) Gpr1_Fun34_YaaH PF01184.19 CDW57583.1 - 9.9e-06 25.3 10.8 1.4e-05 24.8 10.8 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF5058 PF16481.5 CDW57583.1 - 0.013 15.2 2.3 0.019 14.6 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5058) TssN PF17555.2 CDW57583.1 - 0.23 10.8 9.1 0.11 11.8 7.0 1.5 1 1 0 1 1 1 0 Type VI secretion system, TssN DUF2304 PF10066.9 CDW57583.1 - 1.5 9.1 4.9 4.4 7.6 1.9 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2304) TM_PBP2_N PF16296.5 CDW57583.1 - 2.7 8.2 4.7 6.6 6.9 3.6 2.3 2 0 0 2 2 2 0 N-terminal of TM subunit in PBP-dependent ABC transporters CALM_bind PF16025.5 CDW57583.1 - 5 7.7 6.2 11 6.6 6.2 1.5 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Thioredoxin PF00085.20 CDW57584.1 - 3.1e-38 129.9 0.5 3.4e-13 49.5 0.0 5.6 6 0 0 6 6 6 5 Thioredoxin DnaJ PF00226.31 CDW57584.1 - 6.2e-25 87.1 2.0 1.2e-24 86.2 2.0 1.5 1 0 0 1 1 1 1 DnaJ domain Thioredoxin_2 PF13098.6 CDW57584.1 - 3e-06 27.7 0.0 0.029 14.8 0.2 4.3 2 2 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDW57584.1 - 0.0011 19.3 3.5 0.15 12.4 0.0 4.5 4 2 1 5 5 5 1 Thioredoxin-like AhpC-TSA PF00578.21 CDW57584.1 - 0.0058 16.6 1.7 0.031 14.2 0.0 2.8 3 0 0 3 3 3 1 AhpC/TSA family Redoxin PF08534.10 CDW57584.1 - 0.097 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Redoxin Thioredoxin_5 PF13743.6 CDW57584.1 - 0.16 11.6 2.6 2.3 7.9 0.0 3.3 2 1 1 3 3 3 0 Thioredoxin Aminopep PF10023.9 CDW57584.1 - 0.18 11.2 0.0 0.35 10.2 0.0 1.5 1 0 0 1 1 1 0 Putative aminopeptidase Tmemb_185A PF10269.9 CDW57585.1 - 0.00039 20.2 6.9 0.00039 20.2 6.9 1.4 1 1 0 1 1 1 1 Transmembrane Fragile-X-F protein E3_UFM1_ligase PF09743.9 CDW57586.1 - 9.5e-77 258.3 0.3 4.3e-76 256.1 0.3 2.1 2 1 1 3 3 3 1 E3 UFM1-protein ligase 1 MarR_2 PF12802.7 CDW57586.1 - 0.0091 15.9 0.5 7.2 6.6 0.0 3.8 4 0 0 4 4 4 2 MarR family HTH_24 PF13412.6 CDW57586.1 - 0.019 14.5 0.3 2.3 7.9 0.0 3.4 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding FeoC PF09012.10 CDW57586.1 - 0.098 12.7 0.0 20 5.3 0.0 3.0 2 0 0 2 2 2 0 FeoC like transcriptional regulator MutS_V PF00488.21 CDW57587.1 - 4.2e-34 118.2 0.1 4.9e-23 82.1 0.1 2.3 1 1 1 2 2 2 2 MutS domain V MutS_III PF05192.18 CDW57587.1 - 6.4e-27 95.0 7.4 6.6e-27 95.0 0.7 3.0 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 CDW57587.1 - 2.7e-07 30.9 0.0 0.00035 20.9 0.0 2.8 2 0 0 2 2 2 2 MutS domain II MutS_IV PF05190.18 CDW57587.1 - 1.5e-05 25.3 1.7 8.5e-05 22.8 0.0 2.8 2 0 0 2 2 2 1 MutS family domain IV AAA_27 PF13514.6 CDW57587.1 - 0.068 12.8 0.1 0.42 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CDW57587.1 - 0.088 13.3 1.6 3.6 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Epimerase PF01370.21 CDW57588.1 - 1.4e-09 37.8 0.0 5.8e-07 29.2 0.0 2.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CDW57588.1 - 0.00018 21.5 0.0 0.51 10.2 0.0 2.9 2 1 0 2 2 2 2 NAD(P)H-binding RmlD_sub_bind PF04321.17 CDW57588.1 - 0.0044 16.1 0.0 0.017 14.3 0.0 1.9 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CDW57588.1 - 0.015 14.5 0.0 0.03 13.5 0.0 1.5 2 0 0 2 2 2 0 Male sterility protein NmrA PF05368.13 CDW57588.1 - 0.067 12.7 0.0 6.6 6.2 0.0 2.2 2 0 0 2 2 2 0 NmrA-like family GDP_Man_Dehyd PF16363.5 CDW57588.1 - 0.088 12.2 0.0 1.4 8.2 0.0 2.4 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CDW57588.1 - 0.18 12.1 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AAA PF00004.29 CDW57589.1 - 1.1e-15 58.2 0.1 3.6e-15 56.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) LRR_4 PF12799.7 CDW57589.1 - 2e-12 47.1 13.4 6.5e-05 23.2 3.5 4.6 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) PX PF00787.24 CDW57589.1 - 5e-12 45.8 0.0 1.1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 PX domain AAA_22 PF13401.6 CDW57589.1 - 1.9e-10 41.1 0.0 6e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain LRR_8 PF13855.6 CDW57589.1 - 3.7e-10 39.4 11.0 0.00011 21.9 0.5 3.8 2 1 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 CDW57589.1 - 1.9e-09 37.3 3.0 9.5e-06 25.2 0.0 2.3 1 1 2 3 3 3 2 Leucine-rich repeat AAA_16 PF13191.6 CDW57589.1 - 6.2e-08 33.2 0.2 6.8e-06 26.6 0.2 2.7 1 1 0 1 1 1 1 AAA ATPase domain LRR_6 PF13516.6 CDW57589.1 - 1.5e-06 27.8 5.3 3.2 8.0 0.1 5.7 5 0 0 5 5 5 1 Leucine Rich repeat AAA_19 PF13245.6 CDW57589.1 - 0.00045 20.6 0.6 0.0015 18.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CDW57589.1 - 0.00058 19.8 0.4 0.0047 16.9 0.4 2.1 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 CDW57589.1 - 0.00065 19.0 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) LRR_1 PF00560.33 CDW57589.1 - 0.0023 18.2 12.2 3.5 8.5 0.7 6.2 6 1 0 6 6 6 1 Leucine Rich Repeat Viral_helicase1 PF01443.18 CDW57589.1 - 0.073 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 CDW57589.1 - 0.11 12.3 0.2 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Aminotran_3 PF00202.21 CDW57590.1 - 2.6e-78 263.5 0.0 3.4e-78 263.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III CDC50 PF03381.15 CDW57591.1 - 6.1e-89 298.2 0.1 1.4e-88 297.1 0.0 1.5 2 0 0 2 2 2 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF2157 PF09925.9 CDW57591.1 - 0.2 11.5 1.5 17 5.2 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Lipocalin PF00061.23 CDW57592.1 - 4e-14 53.0 0.6 1.2e-13 51.5 0.1 1.7 1 1 0 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_7 PF14651.6 CDW57592.1 - 2.2e-09 37.3 0.1 2.8e-09 37.0 0.1 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Y_phosphatase PF00102.27 CDW57593.1 - 1.6e-40 139.2 0.0 1.8e-30 106.2 0.0 2.3 1 1 1 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 CDW57593.1 - 0.0015 18.3 0.1 0.0027 17.5 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Ribosomal_L34 PF00468.17 CDW57593.1 - 0.0075 16.2 0.8 0.019 14.9 0.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L34 SBP_bac_11 PF13531.6 CDW57593.1 - 0.23 11.2 0.0 0.43 10.3 0.0 1.4 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Y_phosphatase PF00102.27 CDW57595.1 - 9.3e-66 221.7 0.0 1.2e-65 221.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW57595.1 - 0.00015 21.8 0.0 0.00023 21.2 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CDW57595.1 - 0.00016 21.5 0.0 0.00033 20.5 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW57595.1 - 0.0066 16.6 0.0 0.02 15.0 0.0 1.8 1 1 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 CDW57595.1 - 0.12 12.0 0.1 0.55 9.9 0.0 2.0 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) TRM13 PF05206.14 CDW57596.1 - 8.6e-51 173.0 0.3 1.3e-50 172.4 0.3 1.3 1 0 0 1 1 1 1 Methyltransferase TRM13 EF-hand_7 PF13499.6 CDW57596.1 - 3.2e-26 91.6 4.8 3.7e-12 46.5 1.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW57596.1 - 1e-22 77.9 15.7 2e-07 30.1 0.0 5.2 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 CDW57596.1 - 3.9e-20 71.4 8.6 1.6e-09 37.4 1.3 4.9 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.6 CDW57596.1 - 2.1e-17 61.5 10.8 0.00012 21.7 0.2 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 CDW57596.1 - 2.1e-14 52.2 14.2 8.5e-06 25.0 0.0 4.9 5 0 0 5 5 5 4 EF hand zf-TRM13_CCCH PF11722.8 CDW57596.1 - 4.5e-11 42.3 3.6 4.5e-11 42.3 3.6 3.6 5 0 0 5 5 4 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 CDW57596.1 - 2.1e-06 27.5 1.7 4.7e-06 26.4 1.7 1.7 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Dockerin_1 PF00404.18 CDW57596.1 - 1.3e-05 25.3 3.4 0.00027 21.1 0.3 2.8 2 0 0 2 2 2 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 CDW57596.1 - 0.00074 19.8 0.3 0.33 11.3 0.0 2.6 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 CDW57596.1 - 0.019 15.3 0.2 4 7.8 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 CDW57596.1 - 0.077 13.0 1.1 3.2 7.8 0.1 2.7 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SurA_N_2 PF13623.6 CDW57596.1 - 0.093 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 SurA N-terminal domain VCBS PF13517.6 CDW57596.1 - 1.1 10.0 3.6 8.9 7.0 0.4 2.8 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Beach PF02138.18 CDW57597.1 - 7e-29 101.1 0.0 1.1e-28 100.5 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 CDW57597.1 - 1.4e-10 41.6 12.3 0.0011 19.8 0.2 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat WD40_like PF17005.5 CDW57597.1 - 2.2e-06 27.2 0.1 4.3e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 CDW57597.1 - 3.6e-06 27.2 0.2 0.0022 18.2 0.0 3.7 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CDW57597.1 - 0.0029 17.6 0.1 0.032 14.3 0.0 2.3 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Vps16_N PF04841.13 CDW57597.1 - 0.049 12.4 0.0 0.092 11.5 0.0 1.4 1 0 0 1 1 1 0 Vps16, N-terminal region RVT_1 PF00078.27 CDW57598.1 - 5.3e-06 26.1 0.1 1.1e-05 25.1 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EXS PF03124.14 CDW57599.1 - 0.016 14.6 0.1 0.017 14.5 0.1 1.0 1 0 0 1 1 1 0 EXS family Rad60-SLD_2 PF13881.6 CDW57600.1 - 5.5e-23 81.2 0.0 7.1e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDW57600.1 - 0.039 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family NUC202 PF08166.12 CDW57600.1 - 0.076 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 NUC202 domain DUF2407 PF10302.9 CDW57600.1 - 0.081 13.5 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TRAP_beta PF05753.14 CDW57601.1 - 4.3e-50 169.6 0.1 8.3e-50 168.6 0.1 1.4 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) ETF PF01012.21 CDW57601.1 - 1.6e-43 148.8 0.7 1.6e-43 148.8 0.7 1.5 2 0 0 2 2 2 1 Electron transfer flavoprotein domain LIM PF00412.22 CDW57602.1 - 3.7e-10 39.9 30.5 1.9e-05 24.8 7.8 3.6 3 1 1 4 4 4 2 LIM domain zf-RRN7 PF11781.8 CDW57602.1 - 0.0097 15.6 5.2 0.0097 15.6 5.2 2.9 2 0 0 2 2 2 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 MCR PF18509.1 CDW57602.1 - 0.25 11.0 3.4 13 5.5 0.0 3.2 3 0 0 3 3 3 0 Magnetochrome domain Brix PF04427.18 CDW57603.1 - 2.7e-38 132.0 0.5 2.7e-38 132.0 0.5 1.5 2 0 0 2 2 2 1 Brix domain CDK2AP PF09806.9 CDW57604.1 - 2.4e-22 80.1 0.5 3.3e-22 79.7 0.5 1.3 1 1 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein PolyA_pol PF01743.20 CDW57605.1 - 1.3e-32 112.9 1.1 2.2e-32 112.1 1.1 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CDW57605.1 - 1.1e-11 44.4 0.0 3.6e-11 42.7 0.0 1.9 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A HSP70 PF00012.20 CDW57606.1 - 1.3e-61 208.6 0.1 1.7e-61 208.2 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein LRR_8 PF13855.6 CDW57606.1 - 1e-29 102.0 27.2 1.7e-11 43.7 2.7 3.6 2 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 CDW57606.1 - 4.3e-19 68.3 12.5 3.2e-06 27.4 0.3 4.5 3 1 1 4 4 4 4 Leucine Rich repeats (2 copies) MreB_Mbl PF06723.13 CDW57606.1 - 7.5e-13 48.0 2.5 1.7e-11 43.5 0.9 2.1 2 0 0 2 2 2 2 MreB/Mbl protein LRR_1 PF00560.33 CDW57606.1 - 8.9e-08 31.7 14.6 16 6.5 0.1 7.9 8 0 0 8 8 8 3 Leucine Rich Repeat LRR_6 PF13516.6 CDW57606.1 - 6.3e-05 22.7 11.9 0.41 10.8 0.0 6.6 6 0 0 6 6 6 2 Leucine Rich repeat Hydantoinase_A PF01968.18 CDW57606.1 - 0.037 13.3 0.1 0.16 11.2 0.2 1.9 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase UCH PF00443.29 CDW57607.1 - 6e-45 153.7 0.0 1.3e-44 152.7 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW57607.1 - 3.9e-19 69.4 0.0 6.8e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 CDW57607.1 - 2.3e-15 56.7 0.0 6.8e-15 55.2 0.0 1.9 1 0 0 1 1 1 1 MATH domain USP7_ICP0_bdg PF12436.8 CDW57607.1 - 1.2e-11 44.4 0.0 2.1e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 Peptidase_C98 PF15499.6 CDW57607.1 - 0.031 13.8 0.0 5.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase ETF PF01012.21 CDW57609.1 - 2.6e-38 131.7 0.0 4.2e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CDW57609.1 - 9.4e-37 124.9 0.3 2.1e-36 123.8 0.3 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Ribosomal_L3 PF00297.22 CDW57609.1 - 2.5e-22 79.4 0.1 5.2e-22 78.3 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein L3 PAP2 PF01569.21 CDW57610.1 - 8.1e-25 87.2 5.2 2.1e-24 85.8 4.0 1.9 1 1 1 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 CDW57610.1 - 0.0031 18.0 4.1 0.0031 18.0 4.1 2.3 2 1 0 2 2 2 1 PAP2 superfamily C-terminal PAP2_3 PF14378.6 CDW57610.1 - 0.0083 15.8 2.6 0.06 13.0 2.6 2.2 1 1 0 1 1 1 1 PAP2 superfamily DUF202 PF02656.15 CDW57610.1 - 1.8 9.0 7.2 0.33 11.4 1.6 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF202) Sulfate_transp PF00916.20 CDW57611.1 - 3.6e-58 197.1 22.3 1.2e-57 195.4 22.3 1.8 1 1 0 1 1 1 1 Sulfate permease family CBP4 PF07960.11 CDW57612.1 - 0.071 13.0 2.0 0.15 11.9 2.0 1.7 1 1 0 1 1 1 0 CBP4 AHD PF17793.1 CDW57612.1 - 0.081 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 ANC1 homology domain (AHD) CoaE PF01121.20 CDW57613.1 - 2.4e-39 134.9 0.0 3.4e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 CDW57613.1 - 0.009 16.6 0.0 0.035 14.7 0.0 2.0 2 1 0 2 2 2 1 AAA domain CTP_transf_like PF01467.26 CDW57613.1 - 0.02 15.1 0.0 0.057 13.6 0.0 1.9 1 0 0 1 1 1 0 Cytidylyltransferase-like Zeta_toxin PF06414.12 CDW57613.1 - 0.032 13.5 0.1 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Snurportin1 PF11538.8 CDW57614.1 - 1.7e-09 37.7 1.8 5.5e-09 36.1 1.8 2.0 1 0 0 1 1 1 1 Snurportin1 GFO_IDH_MocA PF01408.22 CDW57615.1 - 2e-07 31.8 0.1 5.4e-07 30.5 0.1 1.7 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CDW57615.1 - 0.0017 18.3 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain DUF3446 PF11928.8 CDW57615.1 - 0.0018 18.5 7.9 0.065 13.5 2.4 2.6 2 0 0 2 2 2 2 Early growth response N-terminal domain FERM_N PF09379.10 CDW57616.1 - 3.1e-15 55.9 0.1 4.5e-15 55.3 0.1 1.3 1 0 0 1 1 1 1 FERM N-terminal domain Voldacs PF03517.13 CDW57617.1 - 1.1e-09 38.5 0.0 2.4e-09 37.5 0.0 1.5 1 1 0 1 1 1 1 Regulator of volume decrease after cellular swelling BBL5 PF07289.11 CDW57617.1 - 0.15 11.0 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein PH_TFIIH PF08567.11 CDW57617.1 - 0.17 12.3 0.0 0.43 10.9 0.0 1.8 1 1 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain DUF5008 PF16400.5 CDW57618.1 - 0.063 13.4 0.1 1.3 9.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5008) HMG_box PF00505.19 CDW57618.1 - 2.1 8.8 19.5 0.34 11.4 3.0 4.5 4 1 0 4 4 4 0 HMG (high mobility group) box DFRP_C PF16543.5 CDW57619.1 - 9.6e-22 77.3 8.9 9.6e-22 77.3 8.9 3.3 3 2 1 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 CDW57619.1 - 1.9e-08 34.0 7.2 1.5e-07 31.1 1.0 3.0 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CDW57619.1 - 2.8e-08 33.3 10.0 2.2e-07 30.5 1.9 3.1 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CDW57619.1 - 3.8e-07 29.9 18.5 1.3e-06 28.3 5.8 3.2 3 0 0 3 3 3 2 Zinc finger domain Torus PF16131.5 CDW57619.1 - 0.00021 21.9 14.3 0.00087 20.0 4.1 3.7 3 2 0 3 3 3 2 Torus domain MPM1 PF17234.2 CDW57619.1 - 0.011 16.0 3.4 0.011 16.0 3.4 2.5 2 1 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 zf-CCCH_2 PF14608.6 CDW57619.1 - 0.018 15.5 10.1 0.58 10.7 4.6 2.7 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 CDW57619.1 - 0.062 13.5 0.1 0.062 13.5 0.1 3.4 3 1 1 4 4 4 0 Zinc-finger containing family Ac76 PF05814.11 CDW57619.1 - 0.2 11.7 1.1 18 5.4 0.7 2.7 2 0 0 2 2 2 0 Orf76 (Ac76) zf-C3H1 PF10650.9 CDW57619.1 - 0.32 10.8 2.1 0.81 9.5 2.1 1.7 1 0 0 1 1 1 0 Putative zinc-finger domain SNARE_assoc PF09335.11 CDW57620.1 - 1.6e-22 80.2 5.6 1.6e-22 80.2 5.6 2.1 2 1 0 2 2 2 1 SNARE associated Golgi protein Sarcoglycan_2 PF05510.13 CDW57621.1 - 5.8e-27 94.4 0.0 8.7e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon WD40 PF00400.32 CDW57621.1 - 5.8e-19 68.1 1.6 3.2e-06 27.8 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57621.1 - 0.0039 17.5 0.0 1.7 9.0 0.0 3.9 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW57621.1 - 0.057 13.3 0.0 0.88 9.4 0.0 2.6 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A PAN_1 PF00024.26 CDW57622.1 - 1.6e-14 53.6 6.3 2.1e-08 34.0 1.4 2.7 1 1 1 2 2 2 2 PAN domain APOBEC_N PF08210.11 CDW57623.1 - 6e-19 68.6 2.0 6e-19 68.6 2.0 1.7 2 0 0 2 2 2 1 APOBEC-like N-terminal domain EF-hand_7 PF13499.6 CDW57624.1 - 1.2e-11 44.8 4.1 2.1e-05 24.9 0.1 4.8 3 3 1 4 4 4 4 EF-hand domain pair EF-hand_13 PF17958.1 CDW57624.1 - 8.7e-07 28.7 0.0 0.002 17.9 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_6 PF13405.6 CDW57624.1 - 0.0001 21.9 5.2 0.88 9.7 0.0 5.6 6 1 1 7 7 7 1 EF-hand domain EF-hand_1 PF00036.32 CDW57624.1 - 0.0014 18.0 2.5 0.48 10.1 0.0 4.9 6 0 0 6 6 6 1 EF hand EF-hand_8 PF13833.6 CDW57624.1 - 0.0032 17.3 3.1 1.6 8.6 0.0 4.0 4 0 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW57624.1 - 0.029 14.7 0.4 0.25 11.7 0.0 2.6 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 CDW57624.1 - 0.063 12.8 0.1 1.1 8.9 0.0 3.0 3 0 0 3 3 3 0 EF hand DASH_Dam1 PF08653.10 CDW57624.1 - 0.49 10.2 3.6 22 4.9 0.1 2.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 Rad60-SLD PF11976.8 CDW57625.1 - 1.5e-08 34.3 0.0 1.9e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CDW57625.1 - 0.0008 19.1 0.0 0.001 18.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family TUG-UBL1 PF11470.8 CDW57625.1 - 0.015 15.5 0.0 0.018 15.2 0.0 1.1 1 0 0 1 1 1 0 TUG ubiquitin-like domain SIKE PF05769.11 CDW57627.1 - 9.1e-16 58.3 6.5 1.3e-15 57.8 6.5 1.1 1 0 0 1 1 1 1 SIKE family HisG PF01634.18 CDW57627.1 - 0.015 15.3 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 ATP phosphoribosyltransferase YabA PF06156.13 CDW57627.1 - 0.15 12.7 4.4 3 8.5 0.1 2.4 2 1 0 2 2 2 0 Initiation control protein YabA SF3A3 PF16837.5 CDW57627.1 - 0.16 12.5 0.9 1.1 9.8 0.2 2.1 1 1 1 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 NYD-SP28_assoc PF14775.6 CDW57627.1 - 3.2 7.9 7.0 26 5.0 0.2 2.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain Mt_ATP-synt_B PF05405.14 CDW57628.1 - 6.5e-16 58.4 2.1 6.7e-15 55.1 0.5 2.0 2 0 0 2 2 2 2 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) AlkA_N PF06029.11 CDW57628.1 - 0.0032 17.7 0.2 0.0053 17.0 0.2 1.3 1 0 0 1 1 1 1 AlkA N-terminal domain AraC_binding_2 PF14525.6 CDW57629.1 - 0.02 14.6 0.6 0.27 10.9 0.1 2.0 1 1 1 2 2 2 0 AraC-binding-like domain Uds1 PF15456.6 CDW57629.1 - 0.041 14.1 0.1 12 6.1 0.1 2.3 2 0 0 2 2 2 0 Up-regulated During Septation Mid1 PF12929.7 CDW57629.1 - 0.28 10.4 1.4 4.8 6.3 0.5 2.2 1 1 1 2 2 2 0 Stretch-activated Ca2+-permeable channel component Periviscerokin PF08259.11 CDW57629.1 - 0.29 11.5 4.2 8.4 7.0 0.2 3.0 3 0 0 3 3 3 0 Periviscerokinin family Ion_trans_2 PF07885.16 CDW57631.1 - 1.9e-39 133.5 9.6 2.5e-19 69.0 0.4 2.5 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 CDW57631.1 - 2.6e-10 40.0 4.9 0.00018 20.8 0.1 2.2 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 CDW57631.1 - 0.00035 20.4 0.3 0.0051 16.6 0.1 2.4 2 0 0 2 2 2 1 Inward rectifier potassium channel transmembrane domain 7TM_GPCR_Srb PF02175.16 CDW57631.1 - 0.024 14.4 0.0 0.068 12.9 0.0 1.7 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srb Trypsin PF00089.26 CDW57632.1 - 3.9e-31 108.6 0.0 1.2e-30 107.0 0.0 1.7 1 1 0 1 1 1 1 Trypsin DUF1986 PF09342.11 CDW57632.1 - 0.0015 18.9 0.0 0.0025 18.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) AAA PF00004.29 CDW57633.1 - 1.4e-14 54.6 0.0 3.3e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CDW57633.1 - 6.2e-13 48.8 0.0 4.8e-11 42.7 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 CDW57633.1 - 2.9e-12 46.8 0.2 6.6e-12 45.7 0.2 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 CDW57633.1 - 2e-06 27.9 0.0 3.7e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CDW57633.1 - 4.5e-06 27.2 0.0 0.00047 20.6 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDW57633.1 - 8.1e-06 26.2 0.0 8.9e-05 22.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 CDW57633.1 - 2.1e-05 24.8 0.0 5.3e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 CDW57633.1 - 2.9e-05 23.9 0.0 6e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_24 PF13479.6 CDW57633.1 - 5.5e-05 23.0 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDW57633.1 - 8.6e-05 22.5 0.0 0.00024 21.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDW57633.1 - 0.0011 18.4 0.0 0.047 13.1 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TIP49_C PF17856.1 CDW57633.1 - 0.0014 18.8 0.1 0.0033 17.5 0.1 1.6 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA_30 PF13604.6 CDW57633.1 - 0.0093 15.7 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CDW57633.1 - 0.019 15.0 0.0 0.078 13.0 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 CDW57633.1 - 0.019 14.1 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RuvB_N PF05496.12 CDW57633.1 - 0.024 14.4 0.0 0.065 13.0 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain DUF2075 PF09848.9 CDW57633.1 - 0.031 13.5 0.0 0.12 11.6 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 CDW57633.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.7 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 CDW57633.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDW57633.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 CDW57633.1 - 0.15 11.8 0.0 2.7 7.7 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase Peptidase_M16_M PF16187.5 CDW57634.1 - 8.5e-93 310.7 13.4 1.8e-92 309.6 9.6 2.2 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 CDW57634.1 - 1.2e-40 138.9 4.2 9.7e-40 136.0 0.0 3.3 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CDW57634.1 - 1.5e-28 100.1 0.1 7.5e-16 58.7 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain Imm3 PF14425.6 CDW57634.1 - 0.23 11.5 1.2 0.87 9.6 0.3 2.4 2 0 0 2 2 2 0 Immunity protein Imm3 CybS PF05328.12 CDW57635.1 - 3.8e-23 81.6 1.1 4.3e-23 81.5 1.1 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit RTP1_C1 PF10363.9 CDW57636.1 - 1.4e-16 60.7 1.5 5.6e-15 55.5 0.2 3.0 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 CDW57636.1 - 0.025 14.7 0.1 0.12 12.4 0.0 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF2729 PF10870.8 CDW57636.1 - 0.052 13.4 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2729) PWWP PF00855.17 CDW57637.1 - 7.5e-09 35.9 0.0 1.8e-08 34.6 0.0 1.7 2 0 0 2 2 2 1 PWWP domain zf-HC5HC2H_2 PF13832.6 CDW57637.1 - 0.0042 17.2 4.0 0.04 14.1 1.4 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-4CXXC_R1 PF10497.9 CDW57637.1 - 0.043 14.0 3.1 0.12 12.6 3.1 1.7 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-HC5HC2H PF13771.6 CDW57637.1 - 1.8 8.8 12.0 0.099 12.9 5.6 2.2 2 1 0 2 2 2 0 PHD-like zinc-binding domain ADD_DNMT3 PF17980.1 CDW57637.1 - 6.8 6.8 9.4 0.66 10.0 1.0 2.7 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 CEBP_ZZ PF16366.5 CDW57637.1 - 9.6 6.5 10.5 4 7.8 4.9 2.8 2 1 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-CCHC PF00098.23 CDW57638.1 - 4.9e-41 137.0 54.6 1.2e-08 34.7 2.8 6.3 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_2 PF13696.6 CDW57638.1 - 9.2e-10 38.2 42.8 0.02 14.7 1.9 6.3 6 0 0 6 6 6 5 Zinc knuckle zf-CCHC_4 PF14392.6 CDW57638.1 - 7.2e-09 35.2 39.5 0.011 15.4 0.9 6.1 6 0 0 6 6 6 5 Zinc knuckle zf-CCHC_3 PF13917.6 CDW57638.1 - 8.5e-09 35.2 36.2 0.056 13.4 0.9 6.1 4 2 2 6 6 6 5 Zinc knuckle zf-CCHC_5 PF14787.6 CDW57638.1 - 3.7e-06 26.5 38.0 0.11 12.2 1.2 6.2 5 1 1 6 6 6 6 GAG-polyprotein viral zinc-finger zf-CCHC_6 PF15288.6 CDW57638.1 - 0.0029 17.4 1.6 0.0029 17.4 1.6 6.1 6 0 0 6 6 6 3 Zinc knuckle TRAF6_Z2 PF18048.1 CDW57638.1 - 0.28 11.3 8.2 88 3.3 0.1 5.5 6 0 0 6 6 6 0 TNF receptor-associated factor 6 zinc finger 2 RNase_T PF00929.24 CDW57639.1 - 1.4e-08 35.4 0.0 3.1e-08 34.4 0.0 1.6 1 1 0 1 1 1 1 Exonuclease tRNA-synt_1b PF00579.25 CDW57640.1 - 6.4e-56 189.8 0.0 7.8e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 CDW57640.1 - 0.00044 19.9 0.0 0.0014 18.2 0.0 1.8 1 0 0 1 1 1 1 S4 domain Pkinase PF00069.25 CDW57642.1 - 2.3e-49 168.2 0.0 1.9e-48 165.2 0.0 2.3 2 0 0 2 2 2 1 Protein kinase domain CNH PF00780.22 CDW57642.1 - 4.4e-49 167.6 0.1 7.5e-49 166.8 0.1 1.4 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.17 CDW57642.1 - 7.9e-26 90.9 0.0 1.7e-25 89.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase KELK PF15796.5 CDW57642.1 - 1.6e-14 54.1 14.9 1.6e-14 54.1 14.9 5.2 4 0 0 4 4 4 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase C1_1 PF00130.22 CDW57642.1 - 9.8e-11 41.4 8.8 2.7e-10 40.0 8.8 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DMPK_coil PF08826.10 CDW57642.1 - 6.5e-08 32.6 8.9 6.5e-08 32.6 8.9 5.1 4 0 0 4 4 4 1 DMPK coiled coil domain like Kinase-like PF14531.6 CDW57642.1 - 9.4e-07 28.4 0.0 2.1e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 CDW57642.1 - 3.9e-05 24.3 1.7 0.00015 22.4 1.7 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain PH PF00169.29 CDW57642.1 - 0.048 14.2 0.3 0.23 12.0 0.0 2.4 2 0 0 2 2 2 0 PH domain PBD PF00786.28 CDW57642.1 - 0.061 13.7 1.3 0.6 10.5 0.2 2.8 2 0 0 2 2 2 0 P21-Rho-binding domain Seadorna_VP7 PF07387.11 CDW57642.1 - 0.13 11.2 0.4 0.3 10.1 0.1 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 ZnuA PF01297.17 CDW57642.1 - 9.4 5.6 7.3 2.9 7.2 2.9 2.2 1 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic Peptidase_M20 PF01546.28 CDW57643.1 - 5.5e-33 114.4 0.0 7.1e-33 114.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDW57643.1 - 3.2e-10 39.9 0.0 0.00013 21.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CDW57643.1 - 6.4e-06 26.0 0.0 1.2e-05 25.1 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 CDW57643.1 - 0.00015 20.9 0.0 0.00055 19.0 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase WG_beta_rep PF14903.6 CDW57643.1 - 0.00092 19.4 0.5 0.0022 18.2 0.0 2.0 2 0 0 2 2 2 1 WG containing repeat TRAP-delta PF05404.12 CDW57644.1 - 3.1e-35 121.1 1.0 6.3e-34 116.8 1.0 2.0 1 1 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) Fer2 PF00111.27 CDW57645.1 - 5.1e-13 48.8 0.1 7.3e-13 48.3 0.1 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain zf-RING_5 PF14634.6 CDW57646.1 - 4.6e-08 32.9 6.2 1.2e-07 31.6 6.2 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDW57646.1 - 0.0084 16.0 4.1 0.02 14.7 4.1 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 CCDC144C PF14915.6 CDW57646.1 - 0.093 11.8 6.3 0.13 11.4 6.3 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region zf-C3HC4_2 PF13923.6 CDW57646.1 - 2.3 8.1 12.5 0.16 11.9 6.9 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-4CXXC_R1 PF10497.9 CDW57646.1 - 3.3 8.0 12.8 0.13 12.4 3.1 2.6 1 1 1 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Ribosomal_S15 PF00312.22 CDW57647.1 - 3e-06 27.4 1.4 1.2e-05 25.4 1.4 2.1 1 1 0 1 1 1 1 Ribosomal protein S15 WAP PF00095.21 CDW57648.1 - 1.5e-10 41.3 38.8 4.8e-08 33.3 7.7 3.4 2 1 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' Guanylate_kin PF00625.21 CDW57649.1 - 1e-43 149.1 0.0 1.7e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 CDW57649.1 - 3.8e-11 43.2 0.7 7.4e-11 42.3 0.7 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW57649.1 - 8.8e-09 35.1 0.2 2.1e-08 33.9 0.2 1.6 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.17 CDW57649.1 - 4.2e-06 26.3 0.0 9.7e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW57649.1 - 6e-06 25.8 0.4 2.6e-05 23.8 0.1 2.3 2 1 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CDW57649.1 - 3.5e-05 23.6 0.0 0.00011 22.0 0.0 1.8 1 1 0 1 1 1 1 Variant SH3 domain PDZ_2 PF13180.6 CDW57649.1 - 0.0037 17.5 0.1 0.0092 16.3 0.1 1.7 1 0 0 1 1 1 1 PDZ domain AAA_22 PF13401.6 CDW57649.1 - 0.094 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CDW57649.1 - 0.16 12.0 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Ank_4 PF13637.6 CDW57650.1 - 1.2e-15 57.6 4.0 4.1e-06 27.2 0.3 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW57650.1 - 6.7e-15 55.4 3.1 7e-09 36.2 0.5 2.5 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW57650.1 - 2.3e-10 40.5 5.8 1.2e-05 25.5 0.2 3.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW57650.1 - 2.9e-07 30.2 6.9 0.0092 16.4 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 CDW57650.1 - 0.0001 22.6 10.8 0.7 10.4 0.6 4.5 5 0 0 5 5 5 3 Ankyrin repeat GTP_EFTU PF00009.27 CDW57651.1 - 2.2e-44 151.3 0.0 5e-44 150.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 CDW57651.1 - 2.3e-29 102.5 10.3 4.3e-29 101.6 10.3 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus RNA_pol_L_2 PF13656.6 CDW57651.1 - 2.3e-25 88.1 0.1 5.8e-25 86.9 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain EFG_C PF00679.24 CDW57651.1 - 9.9e-23 80.0 0.0 2.1e-22 79.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 CDW57651.1 - 1.5e-22 79.7 0.0 3.2e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV RNA_pol_L PF01193.24 CDW57651.1 - 1.8e-07 30.5 0.0 8.5e-07 28.3 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain EFG_II PF14492.6 CDW57651.1 - 2.2e-06 27.7 0.0 5.7e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CDW57651.1 - 1.2e-05 25.6 0.0 2.7e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Roc PF08477.13 CDW57651.1 - 0.027 14.7 0.0 0.094 12.9 0.0 1.9 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDW57651.1 - 0.045 13.3 0.0 0.13 11.9 0.0 1.7 1 1 0 1 1 1 0 Ras family Phe_ZIP PF08916.11 CDW57652.1 - 5.1e-15 55.9 8.1 1.4e-14 54.6 8.1 1.8 1 0 0 1 1 1 1 Phenylalanine zipper SH2 PF00017.24 CDW57652.1 - 6.5e-14 51.8 0.1 1.5e-13 50.6 0.1 1.7 1 0 0 1 1 1 1 SH2 domain PH PF00169.29 CDW57652.1 - 2.9e-08 34.2 0.0 8.3e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 PH domain Iwr1 PF08574.10 CDW57652.1 - 1.1e-06 29.6 10.3 3e-06 28.2 10.3 1.8 1 0 0 1 1 1 1 Transcription factor Iwr1 DUF2045 PF09741.9 CDW57653.1 - 1.3e-88 296.4 0.0 1.6e-88 296.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) Sulfotransfer_3 PF13469.6 CDW57654.1 - 4.2e-52 177.7 0.0 6e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 CDW57654.1 - 4.1e-09 36.3 0.0 4.4e-05 23.1 0.0 2.1 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_4 PF17784.1 CDW57654.1 - 0.12 12.2 0.0 1.3 8.8 0.0 2.7 1 1 2 3 3 3 0 Sulfotransferase domain TAFII55_N PF04658.13 CDW57655.1 - 1.3e-39 135.5 1.0 1.6e-38 132.0 0.4 2.1 1 1 1 2 2 2 2 TAFII55 protein conserved region Innexin PF00876.18 CDW57656.1 - 2.6e-98 329.5 8.0 3e-98 329.3 8.0 1.0 1 0 0 1 1 1 1 Innexin JAB PF01398.21 CDW57657.1 - 9.9e-28 96.5 0.0 1.6e-27 95.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 CDW57657.1 - 8.3e-09 35.2 0.0 1.2e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 CDW57657.1 - 0.0014 18.7 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Serpin PF00079.20 CDW57658.1 - 0 1023.2 28.9 1.1e-105 354.0 3.3 3.0 2 1 1 3 3 3 3 Serpin (serine protease inhibitor) DUF2854 PF11016.8 CDW57658.1 - 0.0038 17.2 0.1 4.4 7.2 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF2854) PatG_D PF18047.1 CDW57658.1 - 0.037 14.4 0.2 10 6.6 0.1 3.6 3 0 0 3 3 3 0 PatG Domain MtN3_slv PF03083.16 CDW57658.1 - 0.15 12.1 1.1 33 4.6 0.0 3.4 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange DUF2624 PF11116.8 CDW57658.1 - 4.1 8.4 6.0 80 4.2 0.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2624) PCI PF01399.27 CDW57659.1 - 0.00011 22.7 1.1 0.0092 16.5 0.1 5.9 7 0 0 7 7 7 2 PCI domain CSN8_PSD8_EIF3K PF10075.9 CDW57659.1 - 0.00046 20.2 0.4 1.8 8.6 0.1 3.0 2 0 0 2 2 2 2 CSN8/PSMD8/EIF3K family PT-HINT PF07591.11 CDW57659.1 - 0.065 13.5 0.5 17 5.6 0.1 2.5 2 0 0 2 2 2 0 Pretoxin HINT domain WXG100 PF06013.12 CDW57659.1 - 0.084 13.1 8.1 0.047 13.9 1.2 3.9 4 0 0 4 4 4 0 Proteins of 100 residues with WXG PDZ_6 PF17820.1 CDW57660.1 - 5.4e-05 23.0 0.1 0.71 9.8 0.0 3.4 3 0 0 3 3 3 2 PDZ domain Ribosomal_L37ae PF01780.19 CDW57661.1 - 4.1e-40 135.7 12.1 4.7e-40 135.6 12.1 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 CDW57661.1 - 0.012 15.6 5.1 0.018 15.0 5.1 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Sgf11 PF08209.11 CDW57661.1 - 0.053 13.1 1.0 0.63 9.7 0.1 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) DUF1451 PF07295.11 CDW57661.1 - 0.13 12.3 1.9 0.18 11.9 1.9 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain DUF2175 PF09943.9 CDW57661.1 - 0.21 11.9 4.9 1.6 9.1 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) C1_2 PF03107.16 CDW57661.1 - 0.75 10.2 5.8 1.3 9.4 5.7 1.5 1 1 0 1 1 1 0 C1 domain zf-H2C2_2 PF13465.6 CDW57661.1 - 2.1 9.0 8.9 0.55 10.8 1.4 2.3 1 1 1 2 2 2 0 Zinc-finger double domain DUF2637 PF10935.8 CDW57662.1 - 0.055 13.4 0.0 5.6 6.8 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2637) Rpn3_C PF08375.11 CDW57663.1 - 1.2e-18 67.3 4.5 2.5e-18 66.3 4.5 1.5 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 CDW57663.1 - 8.7e-17 61.5 0.0 2.8e-16 59.9 0.0 1.9 1 0 0 1 1 1 1 PCI domain Helicase_RecD PF05127.14 CDW57663.1 - 0.059 13.2 0.4 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 Helicase Ribosomal_L32p PF01783.23 CDW57664.1 - 2.9e-06 27.5 3.3 4.6e-06 26.8 3.3 1.3 1 0 0 1 1 1 1 Ribosomal L32p protein family RecR PF02132.15 CDW57664.1 - 0.037 13.6 0.9 0.037 13.6 0.9 2.0 2 0 0 2 2 2 0 RecR protein Mu-like_Com PF10122.9 CDW57664.1 - 0.051 13.0 1.8 0.092 12.2 1.8 1.5 1 0 0 1 1 1 0 Mu-like prophage protein Com Prok-RING_1 PF14446.6 CDW57664.1 - 0.084 12.8 1.5 0.3 11.0 1.5 1.8 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 CtIP_N PF10482.9 CDW57665.1 - 0.0047 17.0 9.6 0.0047 17.0 9.6 3.7 2 1 1 3 3 3 1 Tumour-suppressor protein CtIP N-terminal domain DUF1366 PF07104.11 CDW57665.1 - 0.013 15.1 5.6 0.013 15.1 5.6 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF1366) LEM PF03020.15 CDW57665.1 - 0.081 12.5 0.1 0.32 10.6 0.1 2.1 1 1 0 1 1 1 0 LEM domain TPR_MLP1_2 PF07926.12 CDW57665.1 - 0.72 9.9 45.5 1.2 9.2 6.9 4.5 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 CDW57665.1 - 2.2 8.5 42.9 1.9 8.8 3.1 5.2 2 2 1 3 3 3 0 TATA element modulatory factor 1 TATA binding FUSC PF04632.12 CDW57665.1 - 3.1 6.2 17.9 0.9 8.0 2.6 2.1 1 1 1 2 2 2 0 Fusaric acid resistance protein family ZYG-11_interact PF05884.12 CDW57665.1 - 9.5 5.5 11.6 0.77 9.1 3.7 2.4 2 1 0 2 2 2 0 Interactor of ZYG-11 C2 PF00168.30 CDW57666.1 - 3.7e-13 49.6 0.0 6.3e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 C2 domain PI-PLC-Y PF00387.19 CDW57666.1 - 2.6e-06 27.8 1.3 3.9e-06 27.2 0.1 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain LIM PF00412.22 CDW57667.1 - 7.2e-22 77.4 19.1 8.8e-11 41.9 8.1 2.8 2 1 0 2 2 2 2 LIM domain zf-SNAP50_C PF12251.8 CDW57667.1 - 0.0076 15.9 8.5 0.12 12.0 2.3 2.2 1 1 1 2 2 2 2 snRNA-activating protein of 50kDa MW C terminal zf-FLZ PF04570.14 CDW57667.1 - 0.0096 15.4 11.5 0.51 9.8 1.4 3.4 3 0 0 3 3 3 2 zinc-finger of the FCS-type, C2-C2 Sgf11 PF08209.11 CDW57667.1 - 0.1 12.2 0.1 0.1 12.2 0.1 3.2 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) zf-LITAF-like PF10601.9 CDW57667.1 - 0.45 10.8 13.4 0.062 13.6 7.0 2.3 1 1 0 2 2 2 0 LITAF-like zinc ribbon domain zf_UBZ PF18439.1 CDW57667.1 - 1.4 8.6 0.1 1.4 8.6 0.1 4.3 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger Vps39_2 PF10367.9 CDW57667.1 - 9.7 6.7 8.1 28 5.2 0.8 2.9 1 1 2 3 3 3 0 Vacuolar sorting protein 39 domain 2 Peptidase_C1 PF00112.23 CDW57668.1 - 1.4e-47 162.6 9.6 2e-47 162.1 9.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 CDW57668.1 - 4.3e-05 22.5 0.0 0.00023 20.1 0.1 1.9 2 0 0 2 2 2 1 Peptidase C1-like family CTD_bind PF04818.13 CDW57670.1 - 0.039 14.8 0.3 0.19 12.6 0.2 2.2 2 0 0 2 2 2 0 RNA polymerase II-binding domain. Myotub-related PF06602.14 CDW57671.1 - 2.1e-12 46.7 0.0 7.2e-07 28.5 0.0 2.1 1 1 0 2 2 2 2 Myotubularin-like phosphatase domain SH2 PF00017.24 CDW57672.1 - 2.2e-21 75.7 0.0 3.9e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Pkinase_Tyr PF07714.17 CDW57672.1 - 9.8e-06 25.0 0.3 1.4e-05 24.6 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW57672.1 - 0.036 13.4 0.2 0.05 13.0 0.2 1.2 1 0 0 1 1 1 0 Protein kinase domain PA26 PF04636.13 CDW57673.1 - 4.6e-119 398.2 0.0 5.6e-119 397.9 0.0 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) CMD PF02627.20 CDW57673.1 - 0.004 17.2 0.0 0.014 15.5 0.0 2.0 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family DUF3638 PF12340.8 CDW57673.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) DUF2463 PF09591.10 CDW57674.1 - 0.0069 16.3 0.3 0.0094 15.9 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2463) SDF PF00375.18 CDW57675.1 - 3.2e-123 411.6 31.8 3.7e-123 411.4 31.8 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family DUF2231 PF09990.9 CDW57675.1 - 0.8 10.2 5.9 2.2 8.8 0.0 3.6 3 1 0 3 3 3 0 Predicted membrane protein (DUF2231) DUF5083 PF16890.5 CDW57675.1 - 1.3 8.7 3.7 11 5.7 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5083) Thiolase_N PF00108.23 CDW57677.1 - 7.8e-45 153.3 0.0 2e-44 151.9 0.0 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDW57677.1 - 4.7e-43 145.8 0.0 7.9e-43 145.0 0.0 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CDW57677.1 - 0.032 13.8 0.2 0.089 12.3 0.1 1.8 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain Kringle PF00051.18 CDW57678.1 - 6.9e-06 26.3 10.6 0.00017 21.9 4.0 3.4 3 1 0 3 3 3 2 Kringle domain Kringle PF00051.18 CDW57679.1 - 1.5e-18 66.9 32.9 3.3e-11 43.4 6.3 6.0 6 0 0 6 6 6 3 Kringle domain CGI-121 PF08617.10 CDW57680.1 - 2.9e-29 102.3 1.1 3.6e-29 102.0 1.1 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 7tm_3 PF00003.22 CDW57681.1 - 1.7e-35 122.9 22.4 3.3e-35 121.9 22.4 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 CDW57681.1 - 2e-23 83.1 5.6 3.3e-16 59.4 0.0 2.7 3 0 0 3 3 3 2 Receptor family ligand binding region SpaA PF17802.1 CDW57682.1 - 1.8e-08 34.6 0.4 1.9e-06 28.1 0.1 2.9 2 1 0 2 2 2 1 Prealbumin-like fold domain PPC PF04151.15 CDW57682.1 - 0.013 16.5 0.1 0.035 15.2 0.1 1.6 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain CarboxypepD_reg PF13620.6 CDW57682.1 - 0.055 13.8 0.2 0.26 11.6 0.1 2.2 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain Wzt_C PF14524.6 CDW57682.1 - 0.055 13.5 0.0 0.08 13.0 0.0 1.3 1 0 0 1 1 1 0 Wzt C-terminal domain GramPos_pilinD1 PF16555.5 CDW57683.1 - 4.1e-31 108.2 14.5 3.2e-21 76.1 1.5 3.3 3 0 0 3 3 3 3 Gram-positive pilin subunit D1, N-terminal domain SpaA PF17802.1 CDW57683.1 - 1.6e-23 82.8 5.5 1.7e-15 57.1 0.6 3.2 2 0 0 2 2 2 2 Prealbumin-like fold domain CarboxypepD_reg PF13620.6 CDW57683.1 - 8e-05 22.8 0.6 0.81 10.0 0.1 3.2 2 0 0 2 2 2 2 Carboxypeptidase regulatory-like domain Gram_pos_anchor PF00746.21 CDW57683.1 - 0.0013 18.6 0.3 0.0079 16.1 0.1 2.5 2 0 0 2 2 2 1 LPXTG cell wall anchor motif GramPos_pilinD3 PF16570.5 CDW57683.1 - 0.0022 18.7 1.7 0.081 13.7 0.1 3.4 3 0 0 3 3 3 1 Gram-positive pilin backbone subunit 3, Cna-B-like domain AAA_18 PF13238.6 CDW57684.1 - 1.5e-05 25.5 0.4 3.7e-05 24.3 0.4 1.7 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CDW57684.1 - 0.012 15.3 0.8 0.069 12.9 0.6 1.9 2 0 0 2 2 2 0 Cytidylate kinase PRC2_HTH_1 PF18118.1 CDW57684.1 - 0.043 14.6 1.3 0.056 14.2 0.4 1.6 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Aldedh PF00171.22 CDW57685.1 - 2e-170 567.3 1.9 2.2e-170 567.1 1.9 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CDW57685.1 - 0.015 14.7 0.0 0.031 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) HSP9_HSP12 PF04119.12 CDW57685.1 - 0.078 13.4 0.2 7.8 7.0 0.1 2.6 2 0 0 2 2 2 0 Heat shock protein 9/12 Mga PF05043.13 CDW57686.1 - 1.1e-16 61.2 2.1 1.1e-16 61.2 2.1 3.3 4 1 0 4 4 4 1 Mga helix-turn-helix domain HTH_11 PF08279.12 CDW57686.1 - 0.0012 18.7 0.1 0.0044 16.9 0.1 2.0 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 CDW57686.1 - 0.054 13.1 0.0 0.14 11.7 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_Mga PF08280.11 CDW57686.1 - 0.15 12.1 4.3 12 6.0 0.0 3.5 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain Hydrolase_3 PF08282.12 CDW57687.1 - 5.2e-55 186.9 1.6 5.8e-55 186.8 1.6 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 CDW57687.1 - 4.9e-16 59.0 0.1 1.6e-09 37.7 0.0 2.7 1 1 2 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDW57687.1 - 7.8e-06 26.3 0.8 0.002 18.5 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW57687.1 - 0.00024 21.6 0.0 0.0097 16.3 0.0 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDW57687.1 - 0.0048 17.0 0.2 2.2 8.3 0.0 2.6 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PTS_EIIA_1 PF00358.20 CDW57688.1 - 6.4e-46 155.2 0.6 1.4e-45 154.1 0.6 1.6 1 0 0 1 1 1 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 PRD PF00874.20 CDW57688.1 - 1.5e-26 92.5 7.3 1.1e-19 70.5 0.8 2.5 2 0 0 2 2 2 2 PRD domain PTS_EIIC PF02378.18 CDW57688.1 - 2.5e-14 53.1 29.0 3.7e-14 52.5 29.0 1.2 1 0 0 1 1 1 1 Phosphotransferase system, EIIC CAT_RBD PF03123.15 CDW57688.1 - 2.4e-12 46.6 0.5 7e-12 45.1 0.5 1.8 1 0 0 1 1 1 1 CAT RNA binding domain Lactamase_B PF00753.27 CDW57688.1 - 2.2e-07 31.1 0.2 1.7e-06 28.2 0.2 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily DUF4088 PF13317.6 CDW57688.1 - 0.032 13.8 0.2 0.055 13.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) Lactamase_B_2 PF12706.7 CDW57688.1 - 0.043 13.3 0.0 1.7 8.1 0.0 2.7 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Biotin_lipoyl_2 PF13533.6 CDW57688.1 - 0.046 13.5 0.1 0.36 10.7 0.0 2.4 2 0 0 2 2 2 0 Biotin-lipoyl like TatD_DNase PF01026.21 CDW57689.1 - 9.9e-83 277.4 0.0 1.1e-82 277.2 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 CDW57689.1 - 0.002 17.9 0.0 0.29 10.9 0.0 2.4 1 1 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 CDW57689.1 - 0.041 13.2 0.1 0.099 11.9 0.1 1.6 1 1 0 1 1 1 0 Amidohydrolase family RrnaAD PF00398.20 CDW57690.1 - 2.3e-67 226.8 0.1 3.2e-67 226.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase DUF4093 PF13331.6 CDW57690.1 - 5.5e-27 94.0 0.1 1.2e-26 92.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4093) NodS PF05401.11 CDW57690.1 - 0.00013 21.7 0.1 0.00024 20.8 0.1 1.4 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_25 PF13649.6 CDW57690.1 - 0.00039 21.1 0.0 0.0011 19.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW57690.1 - 0.00064 20.3 0.0 0.0014 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW57690.1 - 0.00089 19.1 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW57690.1 - 0.017 15.9 0.0 0.037 14.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MuF_C PF18819.1 CDW57690.1 - 0.017 15.1 0.1 3.4 7.7 0.0 2.5 2 0 0 2 2 2 0 Phage MuF-C-terminal domain Methyltransf_31 PF13847.6 CDW57690.1 - 0.054 13.3 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain HCNGP PF07818.13 CDW57690.1 - 0.12 13.1 0.1 0.37 11.5 0.1 1.8 1 0 0 1 1 1 0 HCNGP-like protein DUF3089 PF11288.8 CDW57691.1 - 3.6e-52 176.8 0.3 6.9e-52 175.9 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) AIF-MLS PF14962.6 CDW57691.1 - 0.0067 16.4 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Mitochondria Localisation Sequence UPF0154 PF03672.13 CDW57691.1 - 0.029 14.4 1.2 0.21 11.6 0.1 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0154) Palm_thioest PF02089.15 CDW57691.1 - 0.046 13.6 0.0 0.074 12.9 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase LepB_N PF18640.1 CDW57691.1 - 0.056 13.0 0.1 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 LepB N-terminal domain SIS PF01380.22 CDW57692.1 - 2.4e-24 85.6 0.2 3.5e-24 85.1 0.2 1.2 1 0 0 1 1 1 1 SIS domain HTH_6 PF01418.17 CDW57692.1 - 6.6e-11 42.0 0.0 1.6e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain, rpiR family SIS_2 PF13580.6 CDW57692.1 - 4.8e-05 23.4 0.2 0.012 15.6 0.0 2.4 1 1 1 2 2 2 2 SIS domain NanE PF04131.14 CDW57693.1 - 6.7e-81 270.1 2.1 7.7e-81 269.9 2.1 1.0 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase IMPDH PF00478.25 CDW57693.1 - 1.7e-06 27.3 1.0 1.7e-05 24.0 0.5 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain IGPS PF00218.21 CDW57693.1 - 0.00092 18.5 0.0 0.002 17.4 0.0 1.6 1 1 1 2 2 2 1 Indole-3-glycerol phosphate synthase DARPP-32 PF05395.12 CDW57693.1 - 0.0012 19.1 0.0 0.0018 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 Asp_Glu_race PF01177.22 CDW57693.1 - 0.0018 18.1 0.2 0.0044 16.9 0.1 1.7 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase FMN_dh PF01070.18 CDW57693.1 - 0.013 14.6 0.6 0.057 12.4 0.6 1.9 1 1 1 2 2 2 0 FMN-dependent dehydrogenase Dus PF01207.17 CDW57693.1 - 0.014 14.6 1.6 0.015 14.4 0.1 1.7 2 1 0 2 2 2 0 Dihydrouridine synthase (Dus) U5_2-snRNA_bdg PF10597.9 CDW57693.1 - 0.13 12.3 0.0 1.6 8.8 0.0 2.2 2 0 0 2 2 2 0 U5-snRNA binding site 2 of PrP8 Gln-synt_N_2 PF16952.5 CDW57693.1 - 0.14 12.0 0.4 0.64 9.9 0.1 2.0 2 0 0 2 2 2 0 Glutamine synthetase N-terminal domain PTS_EIIC PF02378.18 CDW57694.1 - 2.7e-67 227.1 25.9 2.7e-67 227.1 25.9 1.5 2 0 0 2 2 2 1 Phosphotransferase system, EIIC PTS_EIIB PF00367.20 CDW57694.1 - 1.7e-13 49.8 0.1 3.8e-13 48.7 0.1 1.6 1 0 0 1 1 1 1 phosphotransferase system, EIIB PTS_EIIA_1 PF00358.20 CDW57695.1 - 1.7e-35 121.5 1.1 2.4e-35 121.1 1.1 1.2 1 0 0 1 1 1 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 DUF2436 PF10365.9 CDW57695.1 - 0.036 13.8 0.1 0.044 13.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2436) Biotin_lipoyl PF00364.22 CDW57695.1 - 0.083 12.7 0.6 1.6 8.6 0.1 2.6 3 0 0 3 3 3 0 Biotin-requiring enzyme Peptidase_M23 PF01551.22 CDW57695.1 - 0.12 12.6 0.8 0.49 10.6 0.1 2.0 1 1 1 2 2 2 0 Peptidase family M23 ABC_tran PF00005.27 CDW57696.1 - 2.3e-28 99.4 0.1 6.2e-28 98.0 0.1 1.8 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW57696.1 - 3.5e-12 46.8 0.2 4.5e-06 26.7 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW57696.1 - 5.8e-06 25.9 0.5 0.027 13.9 0.1 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDW57696.1 - 5.1e-05 23.9 0.1 5.1e-05 23.9 0.1 2.5 3 0 0 3 3 2 1 AAA domain AAA_15 PF13175.6 CDW57696.1 - 0.00012 21.9 2.6 0.24 11.1 0.1 2.9 2 1 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CDW57696.1 - 0.0018 18.0 0.1 0.0061 16.3 0.1 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDW57696.1 - 0.018 15.4 0.2 0.059 13.6 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW57696.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 CDW57696.1 - 0.038 13.9 0.1 0.11 12.5 0.1 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.6 CDW57696.1 - 0.057 13.1 0.1 0.16 11.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CDW57696.1 - 0.073 13.0 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 CDW57696.1 - 0.096 12.6 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 CDW57696.1 - 0.13 12.7 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 CDW57696.1 - 0.19 11.3 0.8 0.63 9.6 0.1 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDW57696.1 - 0.2 11.8 1.0 1.6 8.9 0.2 2.7 2 1 0 2 2 2 0 AAA domain HATPase_c PF02518.26 CDW57697.1 - 7.3e-13 49.0 0.0 1.1e-12 48.4 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDW57697.1 - 4.5e-08 33.0 0.0 1.2e-07 31.6 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 CDW57697.1 - 6.6e-05 22.9 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CDW57697.1 - 0.00014 21.7 0.4 0.00099 19.0 0.1 2.2 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 CDW57697.1 - 0.00019 21.3 0.0 0.00039 20.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MapZ_EC1 PF18041.1 CDW57697.1 - 0.013 15.8 1.4 0.39 11.0 0.1 2.7 2 0 0 2 2 2 0 MapZ extracellular domain 1 HAMP PF00672.25 CDW57697.1 - 0.024 15.0 0.0 0.13 12.7 0.0 2.2 2 0 0 2 2 2 0 HAMP domain RsbU_N PF08673.10 CDW57697.1 - 0.058 13.5 3.5 0.3 11.2 0.6 2.8 2 1 1 3 3 3 0 Phosphoserine phosphatase RsbU, N-terminal domain Response_reg PF00072.24 CDW57698.1 - 7.8e-27 93.7 0.0 1.4e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDW57698.1 - 2.4e-22 78.8 0.1 5.2e-22 77.7 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal Aminotran_1_2 PF00155.21 CDW57699.1 - 6.6e-30 104.5 0.0 2.8e-29 102.4 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CDW57699.1 - 0.0088 14.9 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase DUF2922 PF11148.8 CDW57699.1 - 0.0099 15.6 0.0 0.027 14.2 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) Alliinase_C PF04864.13 CDW57699.1 - 0.05 12.5 0.0 0.11 11.3 0.0 1.5 1 0 0 1 1 1 0 Allinase Asp-Al_Ex PF06826.12 CDW57700.1 - 7.1e-34 117.0 18.9 9.9e-34 116.6 18.9 1.2 1 0 0 1 1 1 1 Predicted Permease Membrane Region TrkA_C PF02080.21 CDW57700.1 - 0.00019 21.2 0.0 0.079 12.8 0.0 2.5 2 0 0 2 2 2 2 TrkA-C domain Asp23 PF03780.13 CDW57701.1 - 6.2e-31 107.0 8.9 6.2e-31 107.0 8.9 1.6 2 0 0 2 2 2 1 Asp23 family, cell envelope-related function FA_desaturase_2 PF03405.14 CDW57701.1 - 0.011 14.6 1.0 0.012 14.5 1.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase Ral PF11058.8 CDW57701.1 - 0.059 12.9 0.3 0.17 11.4 0.3 1.8 1 1 0 1 1 1 0 Antirestriction protein Ral DUF4080 PF13311.6 CDW57701.1 - 0.12 12.6 0.9 0.16 12.2 0.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4080) Glyco_transf_8 PF01501.20 CDW57702.1 - 1e-76 257.9 13.5 3.4e-47 161.2 3.0 3.0 1 1 2 3 3 3 3 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 CDW57702.1 - 1e-09 38.2 7.5 2.4e-05 23.9 1.5 4.0 2 2 1 3 3 3 3 Glucosyltransferase 24 DUF1786 PF08735.10 CDW57702.1 - 0.0034 16.7 0.1 0.0083 15.4 0.0 1.7 2 0 0 2 2 2 1 Putative pyruvate format-lyase activating enzyme (DUF1786) UPF0176_N PF17773.1 CDW57703.1 - 2.4e-26 91.9 0.0 7.4e-26 90.3 0.0 1.9 2 0 0 2 2 2 1 UPF0176 acylphosphatase like domain Rhodanese PF00581.20 CDW57703.1 - 4.3e-10 40.1 0.0 8.8e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Trans_reg_C PF00486.28 CDW57703.1 - 9.9e-07 28.8 3.5 0.002 18.2 0.2 3.3 3 1 1 4 4 4 2 Transcriptional regulatory protein, C terminal Rhodanese_C PF12368.8 CDW57703.1 - 4.3e-06 27.0 0.0 7.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Rhodanase C-terminal Glyco_hydro_3 PF00933.21 CDW57704.1 - 9.1e-68 229.0 0.1 1e-67 228.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain MFS_1 PF07690.16 CDW57705.1 - 5.3e-28 98.0 46.5 5.5e-20 71.6 26.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 CDW57705.1 - 1.7e-07 30.0 11.2 2e-07 29.8 11.2 1.0 1 0 0 1 1 1 1 Transmembrane secretion effector DUF872 PF05915.12 CDW57705.1 - 0.06 13.5 0.2 0.17 12.1 0.2 1.8 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) MucBP PF06458.12 CDW57706.1 - 1.2e-25 90.2 23.8 5e-14 53.0 5.7 4.2 4 0 0 4 4 4 2 MucBP domain Big_3 PF07523.12 CDW57706.1 - 7.9e-18 64.5 2.0 7.9e-18 64.5 2.0 4.3 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 3) LRR_4 PF12799.7 CDW57706.1 - 3.7e-12 46.3 7.0 0.00017 21.9 0.3 4.7 2 2 2 5 5 5 4 Leucine Rich repeats (2 copies) Gram_pos_anchor PF00746.21 CDW57706.1 - 1.8e-05 24.6 0.5 4.1e-05 23.4 0.5 1.7 1 0 0 1 1 1 1 LPXTG cell wall anchor motif DUF5011 PF16403.5 CDW57706.1 - 2.1e-05 24.6 0.9 2.1e-05 24.6 0.9 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF5011) LRR_8 PF13855.6 CDW57706.1 - 0.00018 21.2 5.5 0.046 13.5 0.2 3.1 2 1 0 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 CDW57706.1 - 0.035 13.6 2.1 2 7.9 0.3 2.5 1 1 1 2 2 2 0 Leucine-rich repeat Kv2channel PF03521.14 CDW57708.1 - 0.0029 17.0 13.4 0.2 11.0 0.5 4.1 1 1 1 4 4 4 3 Kv2 voltage-gated K+ channel Fibin PF15819.5 CDW57708.1 - 0.28 10.9 3.2 36 4.1 0.0 4.0 4 0 0 4 4 4 0 Fin bud initiation factor homologue zf-C4 PF00105.18 CDW57709.1 - 1.3e-28 99.2 15.4 2.9e-28 98.1 15.4 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW57709.1 - 5e-20 72.0 0.4 8.2e-20 71.3 0.4 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PCMT PF01135.19 CDW57711.1 - 1.9e-15 57.2 0.0 8.1e-15 55.1 0.0 1.9 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 CDW57711.1 - 0.0046 16.5 0.0 0.0076 15.8 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.20 CDW57711.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MGAT2 PF05060.14 CDW57712.1 - 3.3e-97 325.7 4.9 4e-97 325.4 4.9 1.0 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) THB PF18362.1 CDW57712.1 - 0.079 12.6 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Tri-helix bundle domain zf-CCCH_3 PF15663.5 CDW57713.1 - 3.4e-41 139.9 7.3 5.1e-41 139.3 7.3 1.3 1 0 0 1 1 1 1 Zinc-finger containing family RabGAP-TBC PF00566.18 CDW57714.1 - 2.6e-50 171.0 0.4 5e-50 170.1 0.4 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RUN PF02759.19 CDW57714.1 - 2.9e-24 85.5 3.1 3.7e-24 85.2 0.1 2.5 2 1 0 2 2 2 1 RUN domain SH3_1 PF00018.28 CDW57714.1 - 8.5e-12 44.5 0.1 1.8e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CDW57714.1 - 9.3e-12 44.5 0.0 2e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CDW57714.1 - 5e-09 35.9 0.3 1e-08 34.9 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain Peptidase_C65 PF10275.9 CDW57714.1 - 0.064 12.7 7.1 0.058 12.8 4.8 2.0 1 1 1 2 2 2 0 Peptidase C65 Otubain DUF592 PF04574.13 CDW57714.1 - 0.15 11.8 0.7 0.35 10.6 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF592) ThiF PF00899.21 CDW57715.1 - 7.5e-55 185.9 0.0 1.1e-54 185.5 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 CDW57715.1 - 2.3e-06 28.1 0.0 4.7e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain DAO PF01266.24 CDW57715.1 - 0.018 14.7 1.4 0.028 14.0 1.4 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDW57715.1 - 0.062 12.5 0.0 0.096 11.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDW57715.1 - 0.063 13.7 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox_3 PF13738.6 CDW57715.1 - 0.12 11.6 1.1 0.21 10.8 1.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CDW57715.1 - 0.19 11.4 1.8 0.32 10.6 0.1 2.2 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 CDW57715.1 - 0.21 11.7 1.2 0.26 11.3 0.1 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 CDW57715.1 - 0.25 10.6 0.4 0.41 9.8 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CDW57715.1 - 0.35 11.5 0.2 0.35 11.5 0.2 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 CDW57716.1 - 1.7e-65 221.0 0.6 2e-65 220.8 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57716.1 - 2.7e-19 69.5 0.0 4.1e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW57716.1 - 5.8e-07 29.7 0.1 1.2e-05 25.4 0.2 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW57716.1 - 0.00029 20.3 0.0 0.00049 19.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDW57716.1 - 0.0019 17.8 0.3 0.037 13.6 0.0 2.4 2 0 0 2 2 2 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 CDW57716.1 - 0.0065 15.3 0.1 0.023 13.5 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CDW57716.1 - 0.017 14.5 0.1 0.045 13.1 0.0 1.8 2 1 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 CDW57716.1 - 0.024 13.7 0.0 0.047 12.7 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Maf PF02545.14 CDW57716.1 - 0.044 13.6 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 Maf-like protein Aconitase PF00330.20 CDW57717.1 - 4.1e-146 487.6 0.0 5.2e-146 487.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDW57717.1 - 1e-41 142.4 0.0 2.4e-41 141.1 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 CDW57717.1 - 0.11 11.2 0.0 0.25 10.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF521) MFS_1 PF07690.16 CDW57718.1 - 1.7e-29 102.9 29.4 3.2e-29 102.0 29.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sigma_M_inh PF17453.2 CDW57718.1 - 0.77 10.2 5.2 0.33 11.4 2.2 1.8 2 0 0 2 2 2 0 Sigma-M inhibitor DUF441 PF04284.13 CDW57718.1 - 8.5 6.4 13.0 0.94 9.5 3.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF441) DUF3197 PF11432.8 CDW57719.1 - 0.026 14.4 0.1 0.038 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3197) DUF5641 PF18701.1 CDW57722.1 - 1.1e-17 63.9 0.3 1.4e-17 63.7 0.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Peptidase_A17 PF05380.13 CDW57723.1 - 1.5e-55 187.6 0.4 3.2e-55 186.6 0.4 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1759 PF03564.15 CDW57723.1 - 4.5e-15 55.9 0.0 3e-14 53.2 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 CDW57723.1 - 1.3e-08 34.8 0.0 1.4e-07 31.5 0.0 2.4 2 1 0 2 2 2 1 Putative peptidase (DUF1758) Integrase_H2C2 PF17921.1 CDW57723.1 - 5e-08 32.9 3.1 5e-08 32.9 3.1 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CDW57723.1 - 6.9e-06 26.3 0.0 2.1e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-CCHC PF00098.23 CDW57725.1 - 5.9e-05 23.0 0.1 0.00011 22.2 0.1 1.4 1 0 0 1 1 1 1 Zinc knuckle PI3K_P85_iSH2 PF16454.5 CDW57725.1 - 0.019 14.6 0.1 0.036 13.7 0.1 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain zf-CCHC_4 PF14392.6 CDW57725.1 - 0.17 11.7 0.6 0.4 10.4 0.6 1.6 1 0 0 1 1 1 0 Zinc knuckle E3_UbLigase_R4 PF13764.6 CDW57727.1 - 1.1e-178 596.1 0.0 6.6e-178 593.5 0.0 1.8 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 tRNA-synt_2c PF01411.19 CDW57728.1 - 3.9e-112 375.6 0.0 1.2e-111 374.0 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetases class II (A) IBP39 PF11422.8 CDW57728.1 - 0.17 11.6 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Initiator binding protein 39 kDa EF-hand_7 PF13499.6 CDW57729.1 - 0.00011 22.6 0.0 0.00084 19.7 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CDW57729.1 - 0.0011 18.8 0.4 0.007 16.2 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 CDW57729.1 - 0.0015 18.0 0.0 0.0066 15.9 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 CDW57729.1 - 0.17 11.8 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair Guanylate_cyc PF00211.20 CDW57730.1 - 1.8e-26 92.9 0.0 2.7e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 CDW57730.1 - 8.2e-21 74.4 0.0 1.7e-20 73.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW57730.1 - 2.9e-12 46.5 0.0 7.3e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain RCR PF12273.8 CDW57730.1 - 0.11 13.1 0.6 0.24 12.0 0.6 1.5 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Mago-bind PF09282.10 CDW57731.1 - 5.2e-12 45.4 0.2 8.9e-12 44.7 0.2 1.4 1 0 0 1 1 1 1 Mago binding TLE_N PF03920.15 CDW57732.1 - 7e-70 233.2 6.2 1e-69 232.6 6.2 1.2 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain WD40 PF00400.32 CDW57732.1 - 1.9e-18 66.4 14.4 0.015 16.1 0.8 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57732.1 - 2.2e-08 34.2 0.1 0.051 13.9 0.0 4.4 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain HALZ PF02183.18 CDW57732.1 - 0.0061 16.7 0.3 0.013 15.7 0.3 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper WD40_like PF17005.5 CDW57732.1 - 0.047 13.0 0.3 3.9 6.7 0.0 2.8 2 1 0 3 3 3 0 WD40-like domain Homeodomain PF00046.29 CDW57733.1 - 9e-22 76.7 4.7 1.5e-21 76.0 4.7 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW57733.1 - 0.0031 17.4 0.1 0.0081 16.0 0.1 1.7 1 0 0 1 1 1 1 Homeobox KN domain Xylo_C PF12529.8 CDW57733.1 - 0.057 13.0 0.1 0.091 12.4 0.1 1.4 1 0 0 1 1 1 0 Xylosyltransferase C terminal Ribosomal_S8e PF01201.22 CDW57736.1 - 5.5e-49 165.9 2.6 8.3e-49 165.3 2.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e F_actin_cap_B PF01115.17 CDW57737.1 - 2e-102 341.9 0.0 3.7e-102 341.0 0.0 1.4 2 0 0 2 2 2 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 CDW57737.1 - 0.01 15.3 0.6 0.04 13.4 0.2 2.2 1 1 1 2 2 2 0 F-actin capping protein alpha subunit GTP_EFTU PF00009.27 CDW57738.1 - 1.7e-54 184.3 0.0 3.5e-54 183.3 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDW57738.1 - 1.2e-12 47.6 0.0 3.4e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDW57738.1 - 6.5e-12 45.7 0.0 1.6e-11 44.4 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CDW57738.1 - 1.9e-08 34.3 0.0 3.9e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 CDW57738.1 - 0.00039 20.2 0.0 0.0079 16.0 0.0 2.9 2 1 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 CDW57738.1 - 0.016 15.3 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase muHD PF10291.9 CDW57739.1 - 1e-23 84.2 0.0 1.2e-23 84.0 0.0 1.1 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Ribosomal_S9 PF00380.19 CDW57740.1 - 4.4e-33 114.4 0.1 5.6e-33 114.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 WD40 PF00400.32 CDW57742.1 - 6.6e-09 36.3 6.2 0.004 18.0 0.5 4.2 3 2 0 3 3 3 2 WD domain, G-beta repeat APC_r PF05923.12 CDW57742.1 - 0.047 13.4 3.2 0.85 9.4 1.8 2.7 2 0 0 2 2 2 0 APC repeat PA28_beta PF02252.18 CDW57743.1 - 1.8e-16 60.1 0.2 3e-16 59.4 0.0 1.5 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 CDW57743.1 - 0.0008 19.4 0.2 0.002 18.1 0.2 1.6 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit Syntaxin PF00804.25 CDW57744.1 - 6.8e-28 97.7 2.4 6.8e-28 97.7 2.4 1.4 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 CDW57744.1 - 1.4e-20 73.0 2.6 3.2e-20 71.9 2.6 1.7 1 1 0 1 1 1 1 SNARE domain Synaptobrevin PF00957.21 CDW57744.1 - 0.01 15.6 1.4 0.017 14.9 1.4 1.4 1 0 0 1 1 1 0 Synaptobrevin DUF3671 PF12420.8 CDW57744.1 - 0.032 14.3 0.3 0.065 13.3 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function MCPsignal PF00015.21 CDW57744.1 - 0.043 13.6 1.0 0.058 13.2 0.6 1.4 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Lge1 PF11488.8 CDW57744.1 - 0.059 13.6 0.3 0.16 12.2 0.3 1.7 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 T2SSF PF00482.23 CDW57744.1 - 0.072 13.0 0.8 0.14 12.1 0.8 1.5 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F Lzipper-MIP1 PF14389.6 CDW57744.1 - 0.074 13.4 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 FliS PF02561.14 CDW57744.1 - 0.081 13.2 0.9 0.18 12.1 0.4 1.7 1 1 1 2 2 2 0 Flagellar protein FliS DUF2207 PF09972.9 CDW57744.1 - 0.14 10.9 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) UPF0258 PF06789.12 CDW57744.1 - 0.16 12.1 1.6 0.27 11.4 1.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0258) Med2 PF11214.8 CDW57744.1 - 0.58 10.3 4.4 4.9 7.4 0.3 2.1 1 1 1 2 2 2 0 Mediator complex subunit 2 Vac_ImportDeg PF09783.9 CDW57745.1 - 1e-60 204.2 3.9 1.3e-60 203.9 3.9 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein VPS28 PF03997.12 CDW57746.1 - 5.2e-64 215.4 0.1 6e-64 215.2 0.1 1.0 1 0 0 1 1 1 1 VPS28 protein Dynactin_p22 PF07426.11 CDW57746.1 - 0.045 13.6 0.2 2.8 7.8 0.1 2.3 2 1 0 2 2 2 0 Dynactin subunit p22 GrpE PF01025.19 CDW57746.1 - 0.58 9.8 2.7 4.5 6.9 0.1 2.7 2 1 1 3 3 3 0 GrpE DUF2205 PF10224.9 CDW57747.1 - 5e-26 90.5 1.0 6.8e-26 90.1 1.0 1.2 1 0 0 1 1 1 1 Short coiled-coil protein FliT PF05400.13 CDW57747.1 - 0.018 15.9 0.9 0.024 15.4 0.9 1.3 1 0 0 1 1 1 0 Flagellar protein FliT MT PF12777.7 CDW57747.1 - 0.03 13.4 0.1 0.034 13.2 0.1 1.1 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor CENP-H PF05837.12 CDW57747.1 - 0.042 14.3 1.1 0.056 13.9 1.1 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Sas10_Utp3 PF04000.15 CDW57747.1 - 0.05 14.2 1.0 0.071 13.7 0.3 1.6 1 1 1 2 2 2 0 Sas10/Utp3/C1D family YabA PF06156.13 CDW57747.1 - 0.078 13.6 0.6 0.098 13.3 0.6 1.2 1 0 0 1 1 1 0 Initiation control protein YabA BCAS3 PF12490.8 CDW57748.1 - 1.7e-10 40.8 0.0 3.9e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 3 WD40 PF00400.32 CDW57748.1 - 0.00032 21.4 5.1 0.069 14.0 0.0 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57748.1 - 0.0034 17.6 0.0 19 5.7 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain T-box PF00907.22 CDW57749.1 - 7.2e-86 287.1 0.2 1e-85 286.7 0.2 1.2 1 0 0 1 1 1 1 T-box Nucleoside_tran PF01733.18 CDW57752.1 - 1.7e-70 237.8 22.1 1.7e-70 237.8 22.1 1.9 2 0 0 2 2 2 1 Nucleoside transporter DUF3784 PF12650.7 CDW57752.1 - 0.062 13.5 0.9 0.062 13.5 0.9 5.5 4 2 0 5 5 5 0 Domain of unknown function (DUF3784) WD40 PF00400.32 CDW57753.1 - 8.5e-25 86.6 19.5 1.3e-05 25.8 0.2 6.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57753.1 - 1.1e-17 64.1 3.4 2.2e-08 34.3 0.6 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW57753.1 - 2.7e-05 24.1 0.0 0.35 10.7 0.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDW57753.1 - 9e-05 21.6 0.0 0.025 13.5 0.0 2.5 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 CDW57753.1 - 0.00092 18.2 0.7 0.52 9.2 0.1 2.4 2 0 0 2 2 2 2 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 CDW57753.1 - 0.099 11.3 2.6 0.11 11.2 0.1 2.1 2 1 1 3 3 3 0 Nucleoporin Nup120/160 WD40_like PF17005.5 CDW57753.1 - 0.2 10.9 0.0 1.8 7.8 0.0 2.3 3 0 0 3 3 3 0 WD40-like domain Mito_carr PF00153.27 CDW57754.1 - 4.6e-45 151.5 0.2 3.8e-23 81.2 0.1 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Antimicrobial20 PF08256.11 CDW57754.1 - 0.78 10.4 3.2 6.3 7.6 1.1 3.0 2 0 0 2 2 2 0 Aurein-like antibiotic peptide Trypsin PF00089.26 CDW57755.1 - 3.9e-97 324.4 0.1 8.5e-51 172.9 0.1 2.1 2 0 0 2 2 2 2 Trypsin Trypsin_2 PF13365.6 CDW57755.1 - 7.4e-18 65.9 0.0 4.9e-09 37.3 0.0 2.3 2 0 0 2 2 2 2 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW57755.1 - 8e-05 23.0 0.1 0.25 11.7 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) DUF316 PF03761.15 CDW57755.1 - 0.00021 20.9 0.0 0.13 11.9 0.0 2.7 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 DUF5583 PF17821.1 CDW57755.1 - 0.073 13.0 0.0 2.1 8.3 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5583) NGP1NT PF08153.12 CDW57756.1 - 8.5e-49 165.0 0.6 1.4e-48 164.3 0.6 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CDW57756.1 - 6.7e-17 61.6 0.0 1.1e-14 54.4 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW57756.1 - 1.5e-07 31.0 0.0 1.6e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDW57756.1 - 5.4e-07 29.7 0.0 1.4e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase Arf PF00025.21 CDW57756.1 - 0.0017 17.8 0.0 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family Dynamin_N PF00350.23 CDW57756.1 - 0.029 14.4 0.2 2.4 8.2 0.1 3.2 2 1 1 3 3 3 0 Dynamin family GTP_EFTU PF00009.27 CDW57756.1 - 0.074 12.6 0.0 4.9 6.6 0.0 2.7 1 1 2 3 3 3 0 Elongation factor Tu GTP binding domain MeaB PF03308.16 CDW57756.1 - 0.13 11.2 0.1 0.8 8.6 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Phe_hydrox_dim PF07976.12 CDW57756.1 - 0.14 12.2 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Phenol hydroxylase, C-terminal dimerisation domain Nucleoporin2 PF04096.14 CDW57757.1 - 6.7e-42 143.1 0.0 1.1e-41 142.4 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 CDW57757.1 - 2.5e-16 60.3 98.0 1.2e-06 29.3 25.5 5.2 3 1 2 5 5 5 5 Nucleoporin FG repeat region Mito_carr PF00153.27 CDW57758.1 - 1.3e-47 159.7 4.3 1.1e-19 70.1 0.1 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CDW57758.1 - 0.004 16.4 0.2 1.9 7.6 0.2 2.4 2 0 0 2 2 2 2 Gammaproteobacterial serine protease dCMP_cyt_deam_1 PF00383.23 CDW57759.1 - 4.1e-15 55.5 0.2 9.8e-15 54.3 0.1 1.8 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region SpoU_methylase PF00588.19 CDW57759.1 - 4.7e-15 56.0 0.0 5.4e-11 42.8 0.0 2.5 1 1 1 2 2 2 2 SpoU rRNA Methylase family MafB19-deam PF14437.6 CDW57759.1 - 6.6e-10 38.9 1.4 2.6e-07 30.5 0.1 2.3 2 0 0 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 CDW57759.1 - 0.031 14.3 0.1 0.1 12.7 0.1 1.9 1 1 0 1 1 1 0 Bd3614-like deaminase Terminase_4 PF05119.12 CDW57759.1 - 0.081 13.4 0.0 0.28 11.6 0.0 1.8 2 0 0 2 2 2 0 Phage terminase, small subunit Steroid_dh PF02544.16 CDW57760.1 - 2.4e-29 102.2 6.2 2.4e-29 102.2 6.2 1.6 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF2407 PF10302.9 CDW57760.1 - 0.12 13.0 0.1 0.2 12.2 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain IMS PF00817.20 CDW57761.1 - 2e-41 141.5 0.0 9e-41 139.3 0.0 2.2 2 0 0 2 2 2 1 impB/mucB/samB family BRCT_2 PF16589.5 CDW57761.1 - 3.8e-13 49.7 0.0 1.4e-12 47.8 0.0 2.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain IMS_C PF11799.8 CDW57761.1 - 4.4e-11 43.5 0.0 1.4e-10 41.9 0.0 1.9 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT PF00533.26 CDW57761.1 - 1.9e-08 34.6 0.0 6.4e-08 32.9 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CDW57761.1 - 2.2e-06 27.5 0.0 3.8e-05 23.5 0.0 2.7 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 CDW57761.1 - 1.6e-05 25.1 0.1 5.7e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain IMS_HHH PF11798.8 CDW57761.1 - 0.0001 22.4 0.2 0.0005 20.2 0.0 2.3 2 0 0 2 2 2 1 IMS family HHH motif UBM PF14377.6 CDW57761.1 - 0.00026 20.3 1.2 0.42 10.1 0.0 3.2 3 0 0 3 3 3 2 Ubiquitin binding region ATP-grasp_4 PF13535.6 CDW57761.1 - 0.043 13.4 0.0 0.44 10.1 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp domain MgtE_N PF03448.17 CDW57761.1 - 1.4 9.5 6.9 3.8 8.2 0.3 3.6 4 0 0 4 4 4 0 MgtE intracellular N domain UPF0139 PF03669.13 CDW57762.1 - 2.3e-43 146.0 1.6 2.7e-43 145.8 1.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) RR_TM4-6 PF06459.12 CDW57763.1 - 0.0025 17.7 11.3 0.0036 17.2 11.3 1.3 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 CDW57763.1 - 0.02 14.0 14.3 0.022 13.9 14.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF1676 PF07898.13 CDW57763.1 - 0.025 14.6 3.2 0.037 14.1 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) GET2 PF08690.10 CDW57763.1 - 0.15 11.7 12.9 0.19 11.4 12.9 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4407 PF14362.6 CDW57763.1 - 0.57 9.5 9.9 0.73 9.1 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.7 CDW57763.1 - 1.3 7.1 21.6 1.4 6.9 21.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 CDW57763.1 - 1.4 7.8 16.2 1.7 7.6 16.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SOG2 PF10428.9 CDW57763.1 - 5 6.2 21.7 5.6 6.0 21.7 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein TipE PF16972.5 CDW57763.1 - 6 5.9 13.7 7.1 5.7 13.7 1.0 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE Ndc1_Nup PF09531.10 CDW57763.1 - 6.4 5.3 16.1 7.2 5.2 16.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PNISR PF15996.5 CDW57763.1 - 8.4 6.6 25.0 11 6.2 25.0 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR ALMT PF11744.8 CDW57763.1 - 9.2 5.0 12.4 13 4.4 12.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4769 PF15992.5 CDW57763.1 - 9.4 5.9 9.7 10 5.8 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) CC190 PF15768.5 CDW57763.1 - 9.7 6.2 19.9 11 6.0 19.9 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 190 TMEM169 PF15052.6 CDW57764.1 - 1.4 9.0 5.2 0.31 11.2 1.4 1.7 2 0 0 2 2 2 0 TMEM169 protein family Serinc PF03348.15 CDW57766.1 - 1.6e-138 462.3 33.6 1.6e-137 459.0 33.6 2.0 1 1 0 1 1 1 1 Serine incorporator (Serinc) Ost5 PF05251.12 CDW57766.1 - 2.4e-26 91.8 6.8 2.4e-26 91.8 6.8 5.4 4 1 0 5 5 5 1 Oligosaccharyltransferase subunit 5 CAAD PF14159.6 CDW57766.1 - 0.0053 16.6 3.6 0.096 12.5 0.5 3.4 2 0 0 2 2 2 1 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase CrgA PF06781.12 CDW57766.1 - 0.63 10.1 6.6 2.2 8.4 0.8 3.7 3 0 0 3 3 3 0 Cell division protein CrgA DUF2464 PF10240.9 CDW57767.1 - 6.2e-37 127.6 0.1 7.1e-37 127.4 0.1 1.1 1 0 0 1 1 1 1 Multivesicular body subunit 12 BCS1_N PF08740.11 CDW57768.1 - 1.9e-39 135.6 2.0 2.5e-39 135.2 2.0 1.1 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CDW57768.1 - 3.6e-19 69.5 0.0 6.4e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW57768.1 - 0.00041 20.8 0.1 0.0012 19.3 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 CDW57768.1 - 0.0013 19.1 0.0 0.0036 17.7 0.0 1.8 2 0 0 2 2 1 1 RNA helicase AAA_25 PF13481.6 CDW57768.1 - 0.0024 17.5 0.0 0.005 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CDW57768.1 - 0.0029 17.2 0.0 0.0058 16.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 CDW57768.1 - 0.0034 17.4 0.0 0.0078 16.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDW57768.1 - 0.0054 16.9 0.0 0.016 15.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 CDW57768.1 - 0.0068 15.6 0.0 0.01 15.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Rad17 PF03215.15 CDW57768.1 - 0.014 15.3 0.0 0.042 13.8 0.0 1.7 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 CDW57768.1 - 0.028 14.9 0.0 0.067 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDW57768.1 - 0.034 14.7 0.0 0.1 13.1 0.0 1.7 2 0 0 2 2 2 0 ABC transporter Esterase PF00756.20 CDW57768.1 - 0.056 13.1 0.3 0.11 12.1 0.3 1.5 1 0 0 1 1 1 0 Putative esterase AAA_11 PF13086.6 CDW57768.1 - 0.057 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDW57768.1 - 0.064 13.5 0.0 0.21 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CDW57768.1 - 0.066 13.0 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 CDW57768.1 - 0.086 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PPV_E1_C PF00519.17 CDW57768.1 - 0.1 11.4 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_22 PF13401.6 CDW57768.1 - 0.11 12.7 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CDW57768.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 KaiC ATPase_2 PF01637.18 CDW57768.1 - 0.17 11.8 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PGF-CTERM PF18204.1 CDW57768.1 - 0.52 10.4 6.5 1.2 9.1 6.5 1.7 1 0 0 1 1 1 0 PGF-CTERM motif Ank_2 PF12796.7 CDW57769.1 - 5.7e-64 212.7 16.5 1.5e-10 41.5 0.0 11.8 9 2 3 12 12 12 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW57769.1 - 1.2e-48 162.8 31.1 1.8e-05 25.2 0.0 16.9 11 5 7 18 18 18 11 Ankyrin repeats (many copies) PARP PF00644.20 CDW57769.1 - 9.4e-37 126.5 0.0 1.8e-36 125.6 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Ank_5 PF13857.6 CDW57769.1 - 2.2e-36 123.5 22.3 7.6e-05 22.9 0.0 15.1 12 3 4 16 16 16 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW57769.1 - 4.4e-27 91.1 29.6 0.0021 18.4 0.0 18.1 22 1 0 22 22 22 7 Ankyrin repeat Ank PF00023.30 CDW57769.1 - 6.7e-27 92.7 33.9 0.00022 21.5 0.0 16.4 17 0 0 17 17 17 6 Ankyrin repeat WGR PF05406.15 CDW57769.1 - 1.1e-16 60.7 0.1 2.3e-16 59.6 0.1 1.6 1 0 0 1 1 1 1 WGR domain Mei5 PF10376.9 CDW57770.1 - 5.6e-06 26.4 0.8 1.1e-05 25.4 0.8 1.7 1 1 0 1 1 1 1 Double-strand recombination repair protein IL34 PF15036.6 CDW57770.1 - 0.015 15.4 0.3 0.03 14.3 0.3 1.5 1 0 0 1 1 1 0 Interleukin 34 Mei5_like PF17021.5 CDW57770.1 - 0.036 14.1 0.1 0.061 13.4 0.1 1.4 1 1 0 1 1 1 0 Putative double-strand recombination repair-like WD-3 PF09765.9 CDW57771.1 - 1.3e-38 133.0 0.7 1.8e-38 132.5 0.7 1.1 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 CDW57771.1 - 7.1e-12 45.3 5.3 1.4e-11 44.4 5.3 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 CDW57771.1 - 1.9e-05 24.9 9.4 4.1e-05 23.8 9.4 1.6 1 0 0 1 1 1 1 Ring finger domain PHD PF00628.29 CDW57771.1 - 0.012 15.4 8.3 0.033 14.1 8.3 1.8 1 0 0 1 1 1 0 PHD-finger zf-rbx1 PF12678.7 CDW57771.1 - 0.053 13.8 7.3 0.16 12.3 7.3 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain OrfB_Zn_ribbon PF07282.11 CDW57771.1 - 0.088 12.8 2.7 0.26 11.3 2.7 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn_ribbon_17 PF17120.5 CDW57771.1 - 0.33 10.6 7.0 0.12 12.0 3.8 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDW57771.1 - 1.1 9.3 6.4 3.9 7.6 6.4 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 CDW57771.1 - 2.7 8.0 9.4 1.4 8.9 5.3 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.22 CDW57771.1 - 2.9 7.9 11.7 2 8.4 5.9 3.2 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Sas10 PF09368.10 CDW57773.1 - 5.7e-27 94.0 10.0 1.8e-26 92.4 10.0 1.9 1 0 0 1 1 1 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 CDW57773.1 - 4.8e-05 23.9 0.0 4.8e-05 23.9 0.0 3.5 4 0 0 4 4 4 1 Sas10/Utp3/C1D family Acyl-CoA_ox_N PF14749.6 CDW57773.1 - 0.024 15.2 0.7 0.024 15.2 0.7 2.6 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal DASH_Dad4 PF08650.10 CDW57773.1 - 0.066 13.2 3.3 0.12 12.3 0.2 2.7 2 0 0 2 2 2 0 DASH complex subunit Dad4 Nif11 PF07862.11 CDW57773.1 - 0.077 13.3 0.3 2.7 8.4 0.0 3.2 3 0 0 3 3 3 0 Nif11 domain TSC22 PF01166.18 CDW57773.1 - 5.4 7.4 7.2 1.3 9.3 3.1 2.2 2 0 0 2 2 2 0 TSC-22/dip/bun family PH_16 PF17838.1 CDW57774.1 - 4.4e-30 104.1 0.0 9.9e-30 103.0 0.0 1.5 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 CDW57774.1 - 6.6e-30 104.7 2.7 1.2e-29 103.8 2.7 1.5 1 0 0 1 1 1 1 RhoGEF domain Not3 PF04065.15 CDW57774.1 - 4.9 6.5 5.9 9.8 5.5 0.4 2.8 3 0 0 3 3 3 0 Not1 N-terminal domain, CCR4-Not complex component PA28_beta PF02252.18 CDW57775.1 - 3.8e-17 62.3 0.3 8.6e-17 61.2 0.3 1.5 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit NAPRTase_C PF17956.1 CDW57775.1 - 0.0021 18.4 0.1 0.72 10.3 0.0 2.8 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase C-terminal domain NHase_beta PF02211.15 CDW57778.1 - 0.0063 16.6 0.1 0.01 15.9 0.1 1.3 1 0 0 1 1 1 1 Nitrile hydratase beta subunit DUF4537 PF15057.6 CDW57778.1 - 0.034 14.2 0.0 0.069 13.2 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4537) HNF-1_N PF04814.13 CDW57779.1 - 3.4e-19 70.2 0.6 5.9e-19 69.4 0.2 1.6 2 1 0 2 2 2 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeodomain PF00046.29 CDW57779.1 - 7.9e-07 28.8 0.2 7.9e-07 28.8 0.2 2.5 2 0 0 2 2 2 1 Homeodomain HTH_37 PF13744.6 CDW57779.1 - 4e-05 23.5 1.4 8.7e-05 22.4 0.5 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 CDW57779.1 - 0.0077 16.3 0.3 0.025 14.6 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 CDW57779.1 - 0.047 14.0 0.3 0.62 10.4 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_19 PF12844.7 CDW57779.1 - 0.047 13.7 0.1 0.28 11.2 0.0 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain MerR-DNA-bind PF09278.11 CDW57779.1 - 0.094 13.3 0.0 0.094 13.3 0.0 2.6 3 0 0 3 3 3 0 MerR, DNA binding 7TM_GPCR_Srw PF10324.9 CDW57781.1 - 4.3e-15 55.8 23.0 5.4e-15 55.5 23.0 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW57781.1 - 5.4e-15 55.4 22.2 5.4e-15 55.4 22.2 1.8 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW57781.1 - 1.3e-06 28.2 13.7 1.3e-06 28.2 13.7 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF5056 PF16479.5 CDW57781.1 - 0.57 10.4 4.1 0.83 9.9 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5056) Ion_trans_2 PF07885.16 CDW57783.1 - 8e-21 73.8 20.9 6.2e-13 48.5 1.6 2.7 3 0 0 3 3 3 2 Ion channel NUDIX_2 PF13869.6 CDW57783.1 - 0.097 12.2 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Nucleotide hydrolase Pox_A9 PF04835.12 CDW57783.1 - 0.12 12.5 2.4 2.6 8.3 0.0 2.9 3 0 0 3 3 3 0 A9 protein conserved region Ufd2P_core PF10408.9 CDW57784.1 - 5.8e-144 481.1 10.2 7.7e-144 480.7 10.2 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 CDW57784.1 - 7.4e-27 93.3 0.4 4.1e-26 90.9 0.6 2.3 2 0 0 2 2 2 1 U-box domain G10 PF01125.17 CDW57786.1 - 7.2e-61 204.2 3.2 8.1e-61 204.1 3.2 1.0 1 0 0 1 1 1 1 G10 protein PP28 PF10252.9 CDW57787.1 - 1.2e-26 92.9 13.3 1.2e-26 92.9 13.3 2.0 2 1 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 Nop53 PF07767.11 CDW57787.1 - 0.15 11.4 23.0 0.2 11.0 23.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) XAP5 PF04921.14 CDW57787.1 - 0.18 11.6 10.2 0.36 10.6 10.2 1.6 1 1 0 1 1 1 0 XAP5, circadian clock regulator TMEM190 PF15431.6 CDW57788.1 - 0.15 12.2 1.1 12 6.0 0.3 2.4 2 0 0 2 2 2 0 Transmembrane protein 190 Abhydrolase_9_N PF15420.6 CDW57788.1 - 3.5 7.6 6.9 10 6.1 6.9 1.8 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus HAT_KAT11 PF08214.11 CDW57789.1 - 4.4e-65 220.3 0.5 4.4e-65 220.3 0.5 1.8 2 0 0 2 2 2 1 Histone acetylation protein KIX PF02172.16 CDW57789.1 - 1e-36 125.0 1.0 3.4e-36 123.4 1.0 2.0 1 0 0 1 1 1 1 KIX domain zf-TAZ PF02135.16 CDW57789.1 - 6.5e-25 87.4 65.5 1.4e-17 63.9 18.2 3.5 3 0 0 3 3 3 2 TAZ zinc finger DUF902 PF06001.13 CDW57789.1 - 1.7e-20 73.2 7.3 1.7e-20 73.2 7.3 2.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 CDW57789.1 - 6.5e-19 67.8 0.1 1.6e-18 66.6 0.1 1.7 1 0 0 1 1 1 1 Bromodomain KIX_2 PF16987.5 CDW57789.1 - 1.7e-06 27.9 0.4 1.7e-06 27.9 0.4 2.2 2 0 0 2 2 2 1 KIX domain DUF4043 PF13252.6 CDW57789.1 - 0.39 9.8 4.1 0.19 10.8 1.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4043) Kelch_1 PF01344.25 CDW57793.1 - 1.3e-18 66.3 6.5 0.0036 16.8 0.0 7.6 7 0 0 7 7 7 4 Kelch motif Kelch_3 PF13415.6 CDW57793.1 - 5.6e-17 61.6 9.7 3.5e-05 24.0 0.0 6.6 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CDW57793.1 - 8.8e-17 60.7 5.6 4.2e-05 23.4 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 CDW57793.1 - 3.7e-15 55.6 6.8 1.7e-06 28.1 0.0 5.8 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 CDW57793.1 - 8.3e-13 48.1 5.4 3.8e-05 23.6 0.0 5.9 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 CDW57793.1 - 3.1e-12 45.9 8.5 0.00011 22.0 0.0 6.0 6 0 0 6 6 6 3 Kelch motif PSI PF01437.25 CDW57793.1 - 4.8e-07 30.2 34.6 3.7e-06 27.4 2.8 7.8 8 1 0 8 8 8 3 Plexin repeat Laminin_EGF PF00053.24 CDW57793.1 - 7.1e-07 29.3 39.2 8.4e-05 22.6 18.6 9.2 9 2 1 10 10 10 2 Laminin EGF domain PSI_integrin PF17205.3 CDW57793.1 - 2.4e-06 27.2 0.7 2.4e-06 27.2 0.7 7.0 6 2 0 6 6 6 2 Integrin plexin domain PX PF00787.24 CDW57794.1 - 9e-14 51.4 0.1 9e-14 51.4 0.1 2.5 2 1 1 3 3 3 1 PX domain RUN PF02759.19 CDW57794.1 - 9.9e-11 41.7 0.0 2.2e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 RUN domain Synaphin PF05835.12 CDW57795.1 - 1.8e-31 109.3 9.3 2.1e-31 109.1 9.3 1.0 1 0 0 1 1 1 1 Synaphin protein NINJA_B PF16136.5 CDW57795.1 - 0.00096 19.5 2.7 0.0015 18.9 2.7 1.2 1 0 0 1 1 1 1 Putative nuclear localisation signal REC1 PF18501.1 CDW57795.1 - 0.0061 16.5 2.8 0.0064 16.4 2.8 1.1 1 0 0 1 1 1 1 Alpha helical recognition lobe domain Cucumo_2B PF03263.13 CDW57795.1 - 0.012 16.1 0.7 0.018 15.5 0.7 1.3 1 0 0 1 1 1 0 Cucumovirus protein 2B OmpH PF03938.14 CDW57795.1 - 0.041 14.2 6.6 0.056 13.8 6.6 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Ribosomal_S8e PF01201.22 CDW57795.1 - 0.069 13.3 2.0 0.09 12.9 2.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S8e Lipocalin PF00061.23 CDW57798.1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family Cpn60_TCP1 PF00118.24 CDW57799.1 - 3.4e-146 487.7 4.1 2.1e-144 481.8 4.1 2.5 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family FF PF01846.19 CDW57799.1 - 3.1e-52 174.5 52.0 1e-11 44.8 3.9 6.5 6 0 0 6 6 6 6 FF domain WW PF00397.26 CDW57799.1 - 1.3e-22 79.6 21.8 9.1e-08 32.1 3.2 3.7 3 0 0 3 3 3 3 WW domain RhoGAP-FF1 PF16512.5 CDW57799.1 - 0.0041 17.8 27.4 0.0079 16.9 2.3 5.7 3 2 2 5 5 5 3 p190-A and -B Rho GAPs FF domain Glyco_hyd_101C PF17451.2 CDW57799.1 - 0.097 13.0 3.9 12 6.3 0.0 4.0 4 0 0 4 4 4 0 Glycosyl hydrolase 101 beta sandwich domain Sda PF08970.10 CDW57799.1 - 0.11 12.3 0.0 0.11 12.3 0.0 3.7 5 0 0 5 5 5 0 Sporulation inhibitor A G_glu_transpept PF01019.21 CDW57800.1 - 1.3e-161 538.9 0.0 1.5e-161 538.7 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Transferrin PF00405.17 CDW57801.1 - 2.7e-47 161.5 1.1 3.9e-23 82.1 0.0 2.2 2 0 0 2 2 2 2 Transferrin YodL PF14191.6 CDW57801.1 - 0.044 14.6 0.0 0.12 13.3 0.0 1.6 1 0 0 1 1 1 0 YodL-like Cir_N PF10197.9 CDW57802.1 - 2.4e-13 50.0 4.5 2.4e-13 50.0 4.5 1.7 2 0 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR zf-CCHC_6 PF15288.6 CDW57802.1 - 0.0017 18.1 0.5 0.0053 16.6 0.5 1.8 1 0 0 1 1 1 1 Zinc knuckle DUF632 PF04782.12 CDW57802.1 - 0.0042 16.5 2.9 0.0064 15.9 2.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF632) DNTTIP1_dimer PF18192.1 CDW57803.1 - 1.2e-16 60.8 0.2 3.1e-16 59.4 0.1 1.7 2 0 0 2 2 2 1 DNTTIP1 dimerisation domain C2 PF00168.30 CDW57804.1 - 6e-06 26.5 0.0 2e-05 24.8 0.0 1.9 1 0 0 1 1 1 1 C2 domain Lactamase_B_6 PF16661.5 CDW57805.1 - 3.6e-58 196.2 0.0 7.3e-58 195.2 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 CDW57805.1 - 6.9e-26 91.4 1.1 1.9e-23 83.5 0.0 3.3 2 1 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 CDW57805.1 - 3.2e-22 78.9 0.1 2.9e-21 75.8 0.0 2.6 3 0 0 3 3 3 1 Beta-Casp domain RMMBL PF07521.12 CDW57805.1 - 2e-12 46.9 0.0 3.8e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 CDW57805.1 - 1.9e-05 24.3 0.0 3.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDW57805.1 - 0.00014 21.9 0.0 0.00086 19.4 0.0 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily PsbQ PF05757.11 CDW57805.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) Methyltransf_23 PF13489.6 CDW57806.1 - 1.1e-05 25.3 0.0 1.5e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW57806.1 - 0.00014 22.5 0.0 0.00022 21.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW57806.1 - 0.0029 18.2 0.0 0.005 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW57806.1 - 0.0036 17.1 0.1 0.0071 16.1 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW57806.1 - 0.0045 17.7 0.0 0.0073 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Pox_MCEL PF03291.16 CDW57807.1 - 9.7e-92 307.6 0.0 1.1e-91 307.4 0.0 1.0 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 CDW57807.1 - 3.3e-11 43.7 0.1 1.6e-10 41.6 0.1 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW57807.1 - 6.4e-08 33.1 0.1 9.8e-07 29.3 0.1 2.7 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW57807.1 - 0.00032 20.5 0.3 0.0086 15.9 0.5 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW57807.1 - 0.004 17.0 0.0 0.0067 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CDW57807.1 - 0.14 12.2 0.1 0.77 9.8 0.1 2.0 1 1 0 1 1 1 0 FtsJ-like methyltransferase ORC4_C PF14629.6 CDW57808.1 - 1.5e-09 37.6 0.5 5.8e-09 35.6 0.1 1.9 1 1 1 2 2 2 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA PF00004.29 CDW57808.1 - 0.013 15.9 0.2 0.11 13.0 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SsgA PF04686.12 CDW57808.1 - 0.12 12.3 0.1 0.79 9.8 0.1 2.3 2 0 0 2 2 2 0 Streptomyces sporulation and cell division protein, SsgA Ras PF00071.22 CDW57809.1 - 1.8e-43 148.0 0.0 2.2e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW57809.1 - 1.1e-16 61.1 0.0 1.5e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW57809.1 - 6.5e-08 32.2 0.0 8.7e-08 31.8 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CDW57809.1 - 0.00032 20.7 0.4 0.73 9.7 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CDW57809.1 - 0.0016 18.5 0.0 0.0025 17.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CDW57809.1 - 0.015 14.7 0.3 0.029 13.8 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 CDW57809.1 - 0.016 15.6 0.0 0.029 14.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 CDW57809.1 - 0.016 15.2 0.6 0.058 13.3 0.1 1.8 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea FeoB_N PF02421.18 CDW57809.1 - 0.016 14.7 0.1 0.2 11.2 0.1 2.3 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 CDW57809.1 - 0.048 13.7 0.1 0.094 12.7 0.1 1.7 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_24 PF13479.6 CDW57809.1 - 0.057 13.1 1.0 0.12 12.1 0.2 1.8 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CDW57809.1 - 0.093 12.2 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CDW57809.1 - 0.12 12.4 0.0 4.2 7.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CDW57809.1 - 0.14 11.3 0.0 1.4 8.0 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF815) RabGAP-TBC PF00566.18 CDW57810.1 - 3.2e-13 49.8 0.3 3.2e-13 49.8 0.3 2.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain ATG16 PF08614.11 CDW57810.1 - 0.0018 18.5 34.4 0.38 10.9 15.3 4.1 2 1 2 4 4 4 2 Autophagy protein 16 (ATG16) DUF724 PF05266.14 CDW57810.1 - 0.0056 16.5 26.6 0.076 12.8 2.6 4.0 2 2 2 4 4 4 3 Protein of unknown function (DUF724) Csm2_III-A PF03750.13 CDW57810.1 - 0.007 17.2 7.1 0.021 15.7 0.4 2.7 2 1 0 2 2 2 1 Csm2 Type III-A Cep57_CLD_2 PF14197.6 CDW57810.1 - 0.011 15.8 24.1 0.44 10.7 4.6 5.1 3 3 0 3 3 3 0 Centrosome localisation domain of PPC89 APG6_N PF17675.1 CDW57810.1 - 0.042 14.4 33.2 0.15 12.6 8.3 4.0 2 1 2 4 4 4 0 Apg6 coiled-coil region Pox_A_type_inc PF04508.12 CDW57810.1 - 0.063 13.1 0.1 0.063 13.1 0.1 5.0 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat DUF4201 PF13870.6 CDW57810.1 - 0.24 11.1 31.6 0.12 12.1 7.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4201) Tup_N PF08581.10 CDW57810.1 - 0.27 11.6 24.3 0.23 11.8 1.1 5.2 3 2 1 5 5 5 0 Tup N-terminal T3SSipB PF16535.5 CDW57810.1 - 0.59 10.6 7.2 0.62 10.5 0.6 3.2 1 1 3 4 4 4 0 Type III cell invasion protein SipB DUF713 PF05218.14 CDW57810.1 - 0.77 9.5 12.5 4.6 6.9 2.6 3.5 2 1 0 3 3 3 0 Protein of unknown function (DUF713) Myb_DNA-bind_4 PF13837.6 CDW57810.1 - 0.88 10.0 5.5 3.7 8.0 0.1 3.2 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain TSC22 PF01166.18 CDW57810.1 - 1.3 9.4 14.9 0.96 9.8 0.6 5.1 5 0 0 5 5 5 0 TSC-22/dip/bun family Fez1 PF06818.15 CDW57810.1 - 1.4 9.3 32.7 0.97 9.9 6.1 3.5 1 1 2 3 3 3 0 Fez1 NPV_P10 PF05531.12 CDW57810.1 - 1.7 9.2 6.8 2.3 8.7 0.1 3.7 2 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 CDW57810.1 - 2.8 8.0 9.5 0.59 10.2 0.9 3.2 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMF_DNA_bd PF12329.8 CDW57810.1 - 4.8 7.2 36.1 3.5 7.7 0.5 5.3 4 2 1 5 5 5 0 TATA element modulatory factor 1 DNA binding Erythro_esteras PF05139.14 CDW57810.1 - 8.2 6.1 11.7 0.058 13.2 1.6 2.1 1 1 1 2 2 2 0 Erythromycin esterase Exonuc_VII_L PF02601.15 CDW57810.1 - 9.4 5.7 21.6 2.7 7.5 5.0 2.2 1 1 0 2 2 2 0 Exonuclease VII, large subunit Bromodomain PF00439.25 CDW57811.1 - 5.4e-39 132.2 0.6 1.4e-18 66.7 0.0 2.7 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 CDW57811.1 - 1.1e-27 96.0 0.7 5.5e-27 93.7 0.1 2.3 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation ASC PF00858.24 CDW57811.1 - 0.034 13.1 0.8 0.073 12.0 0.4 1.7 1 1 0 1 1 1 0 Amiloride-sensitive sodium channel GYD PF08734.11 CDW57811.1 - 0.25 11.3 1.3 8.9 6.3 0.0 3.5 3 0 0 3 3 3 0 GYD domain Pol_alpha_B_N PF08418.10 CDW57811.1 - 9 6.2 27.5 0.17 11.8 5.5 3.6 3 0 0 3 3 3 0 DNA polymerase alpha subunit B N-terminal TLD PF07534.16 CDW57812.1 - 6.1e-28 97.8 0.2 1e-27 97.1 0.2 1.4 1 0 0 1 1 1 1 TLD RabGAP-TBC PF00566.18 CDW57812.1 - 8.2e-12 45.2 2.0 8.2e-12 45.2 2.0 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Clat_adaptor_s PF01217.20 CDW57813.1 - 5.7e-61 204.6 8.3 6.3e-61 204.5 8.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribosomal_S30 PF04758.14 CDW57814.1 - 7.3e-28 96.5 11.6 9e-28 96.2 11.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S30 ubiquitin PF00240.23 CDW57814.1 - 0.0022 17.7 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Peptidase_S9 PF00326.21 CDW57815.1 - 8.7e-38 129.9 0.0 1.3e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDW57815.1 - 5.1e-06 26.3 0.0 0.019 14.6 0.1 2.3 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 CDW57815.1 - 0.00068 20.3 2.3 0.0022 18.6 2.3 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDW57815.1 - 0.0027 17.0 0.0 0.87 8.8 0.0 2.5 3 0 0 3 3 3 2 Serine aminopeptidase, S33 DUF667 PF05018.13 CDW57816.1 - 1e-51 175.3 0.1 1.3e-51 174.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF667) NIL PF09383.10 CDW57816.1 - 0.0077 16.1 0.0 2 8.3 0.0 2.9 3 0 0 3 3 3 2 NIL domain BBE PF08031.12 CDW57816.1 - 0.034 14.2 0.1 0.064 13.4 0.1 1.4 1 0 0 1 1 1 0 Berberine and berberine like DPPIV_N PF00930.21 CDW57817.1 - 2.3e-56 191.1 4.8 1.5e-53 181.8 4.8 3.1 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CDW57817.1 - 6.2e-41 140.2 1.9 1.9e-40 138.6 1.9 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 CDW57817.1 - 0.0014 18.4 0.1 0.0037 17.1 0.0 1.6 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 CDW57817.1 - 0.0046 15.7 0.3 0.012 14.4 0.3 1.7 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 CDW57817.1 - 0.014 14.7 0.1 4.2 6.6 0.0 2.6 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDW57817.1 - 0.015 14.9 0.1 0.072 12.7 0.1 1.8 1 1 1 2 2 2 0 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CDW57817.1 - 0.19 11.3 2.2 13 5.3 0.5 2.9 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Cation_efflux PF01545.21 CDW57818.1 - 6.9e-51 172.8 3.0 6.9e-51 172.8 3.0 2.4 2 1 0 2 2 2 1 Cation efflux family DUF417 PF04224.12 CDW57818.1 - 4.6 6.7 10.5 1.4 8.4 0.2 3.1 3 0 0 3 3 3 0 Protein of unknown function, DUF417 Response_reg PF00072.24 CDW57819.1 - 4.8e-22 78.3 1.1 7e-22 77.7 1.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDW57819.1 - 8.4e-22 77.0 0.0 1.4e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal RQC PF09382.10 CDW57820.1 - 1e-31 109.0 0.3 3.3e-31 107.4 0.3 2.0 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 CDW57820.1 - 1.1e-23 83.0 0.0 2.8e-23 81.7 0.0 1.8 1 0 0 1 1 1 1 HRDC domain Helicase_C PF00271.31 CDW57820.1 - 5.9e-21 74.9 0.2 5.9e-18 65.2 0.0 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 CDW57820.1 - 1.1e-20 74.1 0.0 2.4e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 CDW57820.1 - 3.9e-16 59.5 3.0 1.1e-15 58.0 3.0 1.9 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 CDW57820.1 - 1.6e-06 28.2 0.0 5.3e-06 26.5 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-CXXC PF02008.20 CDW57820.1 - 0.029 14.4 1.8 0.068 13.2 1.8 1.6 1 0 0 1 1 1 0 CXXC zinc finger domain Helicase_Sgs1 PF11408.8 CDW57820.1 - 0.1 12.6 0.0 0.37 10.9 0.0 1.9 2 0 0 2 2 2 0 Sgs1 RecQ helicase DprA_WH PF17782.1 CDW57820.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 DprA winged helix domain DUF763 PF05559.11 CDW57820.1 - 0.13 11.4 0.9 0.43 9.7 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF763) GTP_EFTU PF00009.27 CDW57821.1 - 4.3e-53 179.7 0.4 8.4e-53 178.8 0.4 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CDW57821.1 - 1.2e-51 173.4 2.9 2.3e-51 172.4 2.9 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CDW57821.1 - 1.9e-23 82.3 0.0 4.7e-23 81.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDW57821.1 - 9.5e-09 35.5 1.6 3e-08 33.9 1.6 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDW57821.1 - 1.8e-05 24.5 0.0 4.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_II PF14492.6 CDW57821.1 - 2.3e-05 24.4 0.0 5e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CDW57821.1 - 0.00012 22.2 0.1 0.00047 20.2 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CDW57821.1 - 0.0089 15.8 0.1 0.031 14.0 0.1 1.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 CDW57821.1 - 0.015 14.7 0.0 0.06 12.8 0.0 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 CDW57821.1 - 0.097 12.7 0.2 0.32 11.0 0.0 1.9 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain AAA_22 PF13401.6 CDW57821.1 - 0.15 12.3 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Acetyltransf_9 PF13527.7 CDW57822.1 - 3.8e-39 133.7 0.1 7.7e-39 132.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_17 PF17668.1 CDW57822.1 - 2.4e-23 83.2 0.0 4.8e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Nuc_deoxyrib_tr PF05014.15 CDW57822.1 - 5e-16 58.9 0.0 1e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase SCP2_2 PF13530.6 CDW57822.1 - 1.9e-07 31.4 0.0 5.1e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Sterol carrier protein domain Nuc_deoxyri_tr2 PF15891.5 CDW57822.1 - 0.00096 19.4 0.0 0.0025 18.1 0.0 1.7 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like Acetyltransf_1 PF00583.25 CDW57822.1 - 0.035 14.3 0.4 0.23 11.7 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Pyridox_ox_2 PF12900.7 CDW57823.1 - 5.6e-22 78.3 0.0 6.3e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CDW57823.1 - 9.4e-07 28.9 0.0 1.5e-06 28.3 0.0 1.4 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 CDW57823.1 - 7.4e-06 25.8 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Putative FMN-binding domain HAD_2 PF13419.6 CDW57824.1 - 8.6e-23 81.3 0.3 1.2e-22 80.9 0.3 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW57824.1 - 3.4e-15 56.9 0.0 6.4e-15 56.0 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW57824.1 - 8.3e-07 29.0 0.0 1.5e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDW57824.1 - 3.8e-05 23.7 0.0 0.013 15.6 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW57824.1 - 0.0099 16.3 0.1 0.02 15.3 0.1 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PNK3P PF08645.11 CDW57824.1 - 0.018 14.7 1.0 0.41 10.3 1.0 2.8 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Peptidase_C39_2 PF13529.6 CDW57825.1 - 4.2e-30 105.2 0.1 5.4e-30 104.8 0.1 1.1 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C39 PF03412.15 CDW57825.1 - 2.8e-07 30.4 0.1 0.015 15.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase C39 family Peptidase_C70 PF12385.8 CDW57825.1 - 5.9e-07 29.6 0.0 0.0082 16.1 0.0 2.6 2 1 0 2 2 2 2 Papain-like cysteine protease AvrRpt2 VanY PF02557.17 CDW57826.1 - 1.1e-36 125.6 0.0 2.4e-36 124.5 0.0 1.6 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Glucosaminidase PF01832.20 CDW57826.1 - 5.3e-24 84.5 0.2 1.6e-23 83.0 0.2 1.8 1 0 0 1 1 1 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase NanE PF04131.14 CDW57826.1 - 0.014 14.6 0.5 0.043 13.0 0.2 2.0 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Thioredoxin_8 PF13905.6 CDW57826.1 - 0.025 14.9 0.0 0.4 11.0 0.0 2.6 2 1 1 3 3 3 0 Thioredoxin-like SLT_2 PF13406.6 CDW57826.1 - 0.029 13.6 0.0 0.064 12.5 0.0 1.5 1 0 0 1 1 1 0 Transglycosylase SLT domain Ribul_P_3_epim PF00834.19 CDW57826.1 - 0.032 13.6 1.5 0.35 10.2 0.3 2.9 2 1 0 2 2 2 0 Ribulose-phosphate 3 epimerase family TMP-TENI PF02581.17 CDW57826.1 - 0.083 12.2 0.3 1 8.6 0.2 2.6 3 1 0 3 3 3 0 Thiamine monophosphate synthase Peptidase_M15_4 PF13539.6 CDW57826.1 - 0.085 13.4 0.1 0.27 11.8 0.1 1.9 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase GFO_IDH_MocA PF01408.22 CDW57827.1 - 6.8e-26 91.4 0.1 2.2e-25 89.8 0.1 1.8 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 CDW57827.1 - 9.6e-06 26.1 0.0 2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CDW57827.1 - 0.00014 21.3 0.0 0.0006 19.2 0.0 1.8 1 1 1 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 CDW57827.1 - 0.00059 20.5 0.0 0.0011 19.6 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CDW57827.1 - 0.00088 19.3 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 CDW57827.1 - 0.015 15.7 0.0 0.028 14.9 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF1067 PF06362.11 CDW57827.1 - 0.042 14.6 0.0 0.099 13.4 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1067) PHP_C PF13263.6 CDW57827.1 - 0.047 13.5 0.0 0.16 11.7 0.0 2.0 1 0 0 1 1 1 0 PHP-associated FtsX PF02687.21 CDW57828.1 - 2.9e-13 50.1 17.2 2.9e-08 34.1 1.1 4.1 5 0 0 5 5 5 2 FtsX-like permease family MacB_PCD PF12704.7 CDW57828.1 - 1.7e-06 28.5 0.0 0.0076 16.6 0.0 2.7 2 0 0 2 2 2 2 MacB-like periplasmic core domain IPPT PF01715.17 CDW57828.1 - 0.083 12.7 1.3 0.17 11.7 1.3 1.4 1 0 0 1 1 1 0 IPP transferase DUF4407 PF14362.6 CDW57828.1 - 0.098 12.0 0.3 0.22 10.9 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_tran PF00005.27 CDW57829.1 - 4e-35 121.3 0.0 6.7e-35 120.6 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW57829.1 - 1.1e-07 32.0 0.3 0.015 15.2 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW57829.1 - 6.9e-07 28.9 1.1 0.00025 20.6 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDW57829.1 - 3.3e-05 23.8 0.1 7.1e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 CDW57829.1 - 0.00073 19.3 0.3 0.0042 16.8 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDW57829.1 - 0.0013 19.3 0.5 0.0026 18.3 0.5 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW57829.1 - 0.0015 18.3 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 CDW57829.1 - 0.0025 17.6 0.1 0.11 12.2 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_15 PF13175.6 CDW57829.1 - 0.0034 17.2 0.2 0.93 9.1 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 CDW57829.1 - 0.0053 15.6 0.1 5.1 5.8 0.0 2.9 2 1 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 CDW57829.1 - 0.0071 16.6 0.2 0.049 13.9 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDW57829.1 - 0.01 16.1 0.1 0.59 10.4 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDW57829.1 - 0.015 14.8 0.1 0.37 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 CDW57829.1 - 0.02 13.8 0.0 0.76 8.6 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain AAA_27 PF13514.6 CDW57829.1 - 0.026 14.1 0.1 0.056 13.0 0.1 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDW57829.1 - 0.038 13.9 0.0 0.094 12.6 0.0 1.6 2 0 0 2 2 2 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 CDW57829.1 - 0.04 14.0 0.4 0.077 13.1 0.4 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CDW57829.1 - 0.042 14.2 0.3 0.088 13.2 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CDW57829.1 - 0.044 14.3 0.0 0.28 11.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 CDW57829.1 - 0.056 13.2 0.0 0.22 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Peptidase_C26 PF07722.13 CDW57830.1 - 3.3e-62 210.1 0.0 4.1e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase C26 GATase PF00117.28 CDW57830.1 - 2.4e-13 50.3 0.0 8.4e-13 48.5 0.0 1.9 3 0 0 3 3 3 1 Glutamine amidotransferase class-I Aminoglyc_resit PF10706.9 CDW57830.1 - 2e-08 34.2 0.1 3.3e-08 33.5 0.1 1.3 1 0 0 1 1 1 1 Aminoglycoside-2''-adenylyltransferase NTP_transf_5 PF14907.6 CDW57830.1 - 0.013 15.2 0.1 0.018 14.7 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase DJ-1_PfpI PF01965.24 CDW57830.1 - 0.029 14.2 0.0 0.068 13.0 0.0 1.6 1 0 0 1 1 1 0 DJ-1/PfpI family PolyA_pol PF01743.20 CDW57830.1 - 0.16 12.4 0.0 0.3 11.5 0.0 1.4 1 0 0 1 1 1 0 Poly A polymerase head domain Amidohydro_1 PF01979.20 CDW57831.1 - 4.3e-20 72.3 1.2 7.3e-20 71.6 1.2 1.4 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDW57831.1 - 2.2e-08 34.0 0.3 0.002 17.7 0.0 2.5 3 0 0 3 3 3 2 Amidohydrolase family DUF4041 PF13250.6 CDW57831.1 - 0.21 11.5 0.0 0.44 10.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) HTH_3 PF01381.22 CDW57832.1 - 2.3e-13 50.0 0.0 4.9e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CDW57832.1 - 1.7e-09 37.5 0.0 5.3e-09 36.0 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CDW57832.1 - 1e-07 32.2 0.0 1.8e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDW57832.1 - 1.6e-05 25.3 0.0 4e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Alpha-amylase PF00128.24 CDW57833.1 - 6.6e-55 187.0 0.2 1.8e-28 100.1 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Phosphorylase PF00343.20 CDW57834.1 - 7.5e-296 983.1 2.1 1.3e-294 979.0 1.7 2.0 2 0 0 2 2 2 2 Carbohydrate phosphorylase DUF348 PF03990.14 CDW57834.1 - 0.054 13.3 0.6 0.13 12.0 0.6 1.6 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain DUF915 PF06028.11 CDW57835.1 - 4e-59 200.0 0.0 7.3e-59 199.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) DHH PF01368.20 CDW57835.1 - 2.1e-29 101.7 0.6 4.8e-29 100.6 0.1 1.9 2 0 0 2 2 2 1 DHH family DHHA2 PF02833.14 CDW57835.1 - 8.4e-12 45.5 0.0 1.8e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 DHHA2 domain PGAP1 PF07819.13 CDW57835.1 - 0.00069 19.4 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein DUF1803 PF08820.10 CDW57835.1 - 0.0044 17.0 0.0 0.019 15.0 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1803) LCAT PF02450.15 CDW57835.1 - 0.021 14.0 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 CDW57835.1 - 0.047 13.0 0.0 0.19 11.0 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Radical_SAM PF04055.21 CDW57836.1 - 1.2e-26 94.0 0.0 1.7e-26 93.6 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDW57836.1 - 6.3e-20 71.9 0.1 8.6e-20 71.4 0.1 1.2 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDW57836.1 - 3.6e-09 36.8 0.1 7.1e-09 35.8 0.0 1.5 2 0 0 2 2 2 1 4Fe-4S single cluster domain PFL-like PF02901.15 CDW57837.1 - 7.4e-201 669.2 0.3 9.4e-201 668.8 0.3 1.1 1 0 0 1 1 1 1 Pyruvate formate lyase-like Gly_radical PF01228.21 CDW57837.1 - 4.2e-39 133.3 0.0 1.7e-38 131.4 0.0 2.0 2 0 0 2 2 2 1 Glycine radical DUF3029 PF11230.8 CDW57837.1 - 0.026 12.9 0.1 0.84 7.9 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3029) DNA_topoisoIV PF00521.20 CDW57838.1 - 1.5e-148 495.2 5.4 3.3e-148 494.1 5.4 1.6 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseB PF00204.25 CDW57838.1 - 9.7e-57 191.2 0.3 2.2e-56 190.1 0.3 1.7 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseA_C PF03989.13 CDW57838.1 - 2.2e-31 107.1 0.0 5.2e-09 35.4 0.0 6.1 6 0 0 6 6 6 5 DNA gyrase C-terminal domain, beta-propeller DNA_gyraseB_C PF00986.21 CDW57838.1 - 9.5e-30 102.6 0.7 3.1e-29 100.9 0.7 2.0 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CDW57838.1 - 1.6e-22 80.1 0.1 5.9e-22 78.3 0.1 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDW57838.1 - 8.4e-18 64.5 0.4 3.7e-17 62.4 0.0 2.5 2 0 0 2 2 2 1 Toprim domain Poxvirus PF06227.12 CDW57838.1 - 0.065 13.0 0.4 0.18 11.6 0.4 1.7 1 0 0 1 1 1 0 dsDNA Poxvirus DUF5446 PF17522.2 CDW57838.1 - 0.13 12.4 7.6 4.2 7.6 2.3 3.9 2 1 1 3 3 3 0 Family of unknown function (DUF5446) CoA_binding_2 PF13380.6 CDW57839.1 - 3e-29 101.8 0.0 3.6e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 CDW57839.1 - 9.5e-09 35.8 0.0 1.4e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 CoA binding domain Nudix_N PF12535.8 CDW57840.1 - 1.9e-24 85.0 0.0 3.4e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Hydrolase of X-linked nucleoside diphosphate N terminal NUDIX PF00293.28 CDW57840.1 - 2e-07 31.1 0.0 3.5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain CPSase_L_D2 PF02786.17 CDW57841.1 - 2.9e-79 265.5 0.0 4.5e-79 264.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 CDW57841.1 - 5.3e-35 119.8 0.0 1.5e-34 118.3 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain DAO PF01266.24 CDW57841.1 - 1.3e-29 103.9 0.0 2.1e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Biotin_carb_N PF00289.22 CDW57841.1 - 6.8e-26 91.0 0.0 1.6e-25 89.8 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain PCC_BT PF18140.1 CDW57841.1 - 5.5e-18 65.5 0.0 2e-17 63.7 0.0 1.9 3 0 0 3 3 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_lipoyl PF00364.22 CDW57841.1 - 6.6e-12 45.1 1.6 1.4e-11 44.1 1.6 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CDW57841.1 - 8.4e-06 25.5 0.0 1.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CDW57841.1 - 3.9e-05 23.3 0.0 7.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain NAD_binding_8 PF13450.6 CDW57841.1 - 0.0027 17.9 0.0 0.012 15.9 0.0 2.1 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain RimK PF08443.11 CDW57841.1 - 0.0035 17.0 0.0 0.017 14.8 0.0 2.0 1 1 0 1 1 1 1 RimK-like ATP-grasp domain GCV_H PF01597.19 CDW57841.1 - 0.0036 17.2 0.2 0.0083 16.0 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein FAD_binding_2 PF00890.24 CDW57841.1 - 0.011 14.8 0.0 0.022 13.8 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NQRA PF05896.11 CDW57841.1 - 0.013 14.9 0.2 0.025 14.0 0.2 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) Pyr_redox_2 PF07992.14 CDW57841.1 - 0.017 14.4 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ATPgrasp_ST PF14397.6 CDW57841.1 - 0.031 13.5 0.0 0.096 11.9 0.0 1.7 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp RnfC_N PF13375.6 CDW57841.1 - 0.043 13.8 2.8 0.067 13.1 0.1 2.4 3 0 0 3 3 2 0 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.6 CDW57841.1 - 0.055 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Biotin-lipoyl like HlyD_D23 PF16576.5 CDW57841.1 - 0.09 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion Thi4 PF01946.17 CDW57841.1 - 0.11 11.8 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Thi4 family SNF PF00209.18 CDW57842.1 - 3.7e-130 435.1 30.2 2.2e-123 412.8 21.4 2.0 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family DUF3464 PF11947.8 CDW57842.1 - 0.0075 16.0 0.1 0.36 10.6 0.2 2.6 2 0 0 2 2 2 1 Photosynthesis affected mutant 68 DUF2207 PF09972.9 CDW57842.1 - 0.062 12.1 0.1 0.062 12.1 0.1 2.8 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) Globin PF00042.22 CDW57843.1 - 4.5e-08 33.6 0.8 6.2e-08 33.2 0.2 1.5 2 0 0 2 2 2 1 Globin DNTTIP1_dimer PF18192.1 CDW57843.1 - 0.0026 18.0 2.2 0.2 12.0 0.1 2.8 3 0 0 3 3 3 2 DNTTIP1 dimerisation domain DUF1759 PF03564.15 CDW57843.1 - 0.16 11.9 2.0 0.31 11.0 2.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1759) Fringe PF02434.16 CDW57844.1 - 3.2e-57 193.9 0.3 3.9e-57 193.6 0.3 1.0 1 0 0 1 1 1 1 Fringe-like Homeodomain PF00046.29 CDW57845.1 - 1.3e-21 76.2 5.7 2.4e-21 75.3 5.7 1.5 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 CDW57845.1 - 0.076 12.5 0.6 0.14 11.6 0.6 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeodomain PF00046.29 CDW57846.1 - 3.6e-22 78.0 7.0 5.6e-22 77.4 7.0 1.3 1 0 0 1 1 1 1 Homeodomain Chalcone_2 PF16035.5 CDW57846.1 - 0.0014 18.4 0.2 0.0019 18.0 0.2 1.1 1 0 0 1 1 1 1 Chalcone isomerase like EzrA PF06160.12 CDW57846.1 - 0.0038 15.5 0.9 0.0049 15.1 0.9 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Homez PF11569.8 CDW57846.1 - 0.014 14.9 2.5 0.025 14.0 2.5 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 CDW57846.1 - 0.062 13.2 0.2 0.14 12.1 0.2 1.6 1 0 0 1 1 1 0 Homeobox KN domain EB PF01683.18 CDW57847.1 - 7.6e-21 74.2 84.6 1.2e-06 28.7 1.8 7.2 6 1 1 7 7 7 7 EB module EGF_MSP1_1 PF12946.7 CDW57847.1 - 0.0086 16.1 5.9 0.0086 16.1 5.9 7.7 7 0 0 7 7 7 3 MSP1 EGF domain 1 hEGF PF12661.7 CDW57847.1 - 0.18 12.5 0.4 0.18 12.5 0.4 9.3 9 1 0 9 9 9 0 Human growth factor-like EGF cEGF PF12662.7 CDW57847.1 - 0.4 10.7 49.3 0.059 13.3 1.6 7.3 7 0 0 7 7 7 0 Complement Clr-like EGF-like PAN_1 PF00024.26 CDW57848.1 - 2.9e-10 39.9 7.4 3.8e-05 23.6 0.1 2.7 1 1 1 2 2 2 2 PAN domain 60KD_IMP PF02096.20 CDW57849.1 - 8.4e-08 32.3 0.0 1.4e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein FAM91_N PF14647.6 CDW57850.1 - 1.1e-117 392.7 4.0 1.2e-116 389.4 4.0 2.0 1 1 0 1 1 1 1 FAM91 N-terminus FAM91_C PF14648.6 CDW57850.1 - 2.4e-112 375.9 0.0 3.8e-112 375.3 0.0 1.2 1 0 0 1 1 1 1 FAM91 C-terminus HU-CCDC81_bac_1 PF18174.1 CDW57850.1 - 0.0026 17.6 0.0 0.0069 16.3 0.0 1.6 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 1 fn3 PF00041.21 CDW57851.1 - 7.7e-73 240.9 21.4 2e-14 53.7 1.1 8.4 6 2 0 6 6 6 6 Fibronectin type III domain I-set PF07679.16 CDW57851.1 - 2.9e-47 158.6 0.0 1.1e-16 60.7 0.0 5.5 5 0 0 5 5 5 4 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW57851.1 - 4.9e-42 142.4 0.1 7.6e-14 52.1 0.0 6.1 6 0 0 6 6 6 4 Immunoglobulin domain Ig_2 PF13895.6 CDW57851.1 - 6.8e-31 106.4 0.0 5.2e-10 39.5 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 CDW57851.1 - 7.1e-24 83.8 0.0 8.5e-08 32.3 0.0 4.7 4 0 0 4 4 4 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 CDW57851.1 - 4e-15 56.1 16.7 0.00086 19.8 1.2 7.5 6 1 0 6 6 6 4 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 CDW57851.1 - 3.1e-13 49.8 1.6 0.057 13.6 0.0 7.7 5 3 3 8 8 8 3 Immunoglobulin V-set domain DUF2369 PF10179.9 CDW57851.1 - 4.4e-10 39.8 0.0 0.022 15.1 0.0 4.9 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Interfer-bind PF09294.10 CDW57851.1 - 3.8e-09 36.8 0.0 0.5 10.7 0.1 6.0 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III C2-set_2 PF08205.12 CDW57851.1 - 2.1e-07 30.9 0.0 0.0057 16.7 0.0 4.6 6 0 0 6 6 4 1 CD80-like C2-set immunoglobulin domain Neogenin_C PF06583.12 CDW57851.1 - 2.4e-07 30.9 25.0 2.5e-06 27.6 11.9 3.1 2 1 0 3 3 3 2 Neogenin C-terminus C1-set PF07654.15 CDW57851.1 - 1.5e-05 25.3 0.0 0.81 10.1 0.0 4.6 4 0 0 4 4 4 1 Immunoglobulin C1-set domain Protocadherin PF08374.11 CDW57851.1 - 2.2e-05 24.5 0.0 4.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Protocadherin Tissue_fac PF01108.17 CDW57851.1 - 0.00016 21.5 2.7 1.5 8.7 0.0 5.9 6 1 0 6 6 6 1 Tissue factor Ig_4 PF16680.5 CDW57851.1 - 0.011 16.0 0.0 1.8 8.9 0.0 3.4 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 CDW57851.1 - 0.012 15.2 0.0 0.82 9.3 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin domain Reeler PF02014.16 CDW57851.1 - 0.025 15.3 0.3 18 6.1 0.0 3.6 3 0 0 3 3 3 0 Reeler domain Mst1_SARAH PF11629.8 CDW57851.1 - 0.66 10.1 1.7 0.62 10.2 0.2 1.7 2 0 0 2 2 1 0 C terminal SARAH domain of Mst1 SPX PF03105.19 CDW57851.1 - 0.99 9.3 4.4 1.7 8.5 4.4 1.3 1 0 0 1 1 1 0 SPX domain PC_rep PF01851.22 CDW57852.1 - 1.5e-10 41.0 7.9 3e-07 30.5 0.0 3.5 3 0 0 3 3 3 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CDW57852.1 - 0.00013 22.3 0.0 0.00031 21.1 0.0 1.6 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 CDW57852.1 - 0.02 15.1 0.1 2.4 8.7 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat Galactosyl_T PF01762.21 CDW57853.1 - 2.7e-52 177.4 0.3 4.2e-52 176.8 0.3 1.3 1 0 0 1 1 1 1 Galactosyltransferase Putative_PNPOx PF01243.20 CDW57853.1 - 0.13 12.5 0.0 0.4 10.9 0.0 1.8 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Galactosyl_T PF01762.21 CDW57854.1 - 7.2e-31 107.5 1.0 1.2e-15 57.9 0.8 2.0 1 1 1 2 2 2 2 Galactosyltransferase Sulfotransfer_4 PF17784.1 CDW57854.1 - 0.054 13.3 0.1 0.064 13.1 0.1 1.1 1 0 0 1 1 1 0 Sulfotransferase domain Glycos_transf_2 PF00535.26 CDW57855.1 - 5.7e-27 94.6 0.0 9.2e-27 93.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 CDW57855.1 - 1e-05 25.1 0.1 2.6e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Ricin_B_lectin PF00652.22 CDW57855.1 - 0.0068 16.7 0.1 0.012 15.9 0.1 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_2 PF10111.9 CDW57855.1 - 0.0073 15.8 0.0 3.7 6.9 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Pox_A11 PF05061.13 CDW57856.1 - 0.021 14.1 0.4 0.023 14.0 0.4 1.1 1 0 0 1 1 1 0 Poxvirus A11 Protein HlyD_2 PF12700.7 CDW57856.1 - 0.12 11.0 2.2 0.13 10.9 2.2 1.0 1 0 0 1 1 1 0 HlyD family secretion protein ETRAMP PF09716.10 CDW57856.1 - 0.17 11.9 0.6 0.25 11.4 0.6 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF515 PF04415.12 CDW57856.1 - 0.33 9.3 1.8 0.41 9.0 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF2116 PF09889.9 CDW57856.1 - 0.35 10.9 1.9 0.57 10.2 1.9 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Ribonuclease_3 PF00636.26 CDW57857.1 - 5.2e-41 139.5 0.0 2.8e-19 69.7 0.0 3.2 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CDW57857.1 - 2.4e-38 131.2 0.0 1.1e-19 70.9 0.0 3.4 3 0 0 3 3 3 2 Ribonuclease-III-like dsrm PF00035.26 CDW57857.1 - 7e-10 39.5 0.0 1.7e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif YHS PF04945.13 CDW57857.1 - 0.2 11.8 1.1 14 5.9 0.1 2.5 2 0 0 2 2 2 0 YHS domain SR-25 PF10500.9 CDW57857.1 - 0.88 9.1 7.1 1.9 8.0 7.1 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 CDW57858.1 - 4.5e-31 108.2 0.0 7.1e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57858.1 - 1.4e-30 106.4 0.0 2.7e-30 105.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 CDW57858.1 - 2.4e-05 25.4 15.3 8.6e-05 23.6 15.3 2.0 1 0 0 1 1 1 1 Activin types I and II receptor domain APH PF01636.23 CDW57858.1 - 0.00022 21.3 0.0 0.00045 20.2 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW57858.1 - 0.00026 19.9 0.0 0.00046 19.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Caprin-1_dimer PF18293.1 CDW57859.1 - 6.5e-26 91.1 2.0 8.2e-26 90.8 0.0 2.3 2 0 0 2 2 2 1 Caprin-1 dimerization domain V-SNARE_C PF12352.8 CDW57861.1 - 0.0016 18.7 1.6 0.0016 18.7 1.6 2.5 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus MMPL PF03176.15 CDW57861.1 - 0.081 11.8 1.0 0.13 11.1 1.0 1.3 1 0 0 1 1 1 0 MMPL family TRPM_tetra PF16519.5 CDW57861.1 - 0.11 12.6 0.5 0.11 12.6 0.5 2.3 3 0 0 3 3 3 0 Tetramerisation domain of TRPM DUF1664 PF07889.12 CDW57861.1 - 0.12 12.4 4.1 0.51 10.4 0.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 CDW57861.1 - 0.19 11.8 4.6 9.8 6.3 0.1 2.8 3 1 0 3 3 3 0 RasGAP C-terminus Snapin_Pallidin PF14712.6 CDW57861.1 - 0.21 12.0 0.2 0.21 12.0 0.2 2.7 3 0 0 3 3 3 0 Snapin/Pallidin Fib_alpha PF08702.10 CDW57861.1 - 0.61 10.3 5.1 3 8.0 0.9 3.1 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family PDEase_I PF00233.19 CDW57862.1 - 1.1e-64 218.5 3.3 2.1e-64 217.5 3.3 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 CDW57862.1 - 0.00048 20.3 0.1 0.0016 18.7 0.1 1.9 2 0 0 2 2 2 1 HD domain GAF_2 PF13185.6 CDW57862.1 - 0.0021 18.4 0.0 0.39 11.0 0.0 2.5 1 1 1 2 2 2 2 GAF domain WAP PF00095.21 CDW57864.1 - 7.3e-17 61.5 22.7 7.8e-10 39.0 6.8 2.3 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' zf-SAP30 PF13866.6 CDW57864.1 - 0.23 11.6 0.3 0.23 11.6 0.3 1.9 2 0 0 2 2 2 0 SAP30 zinc-finger Inhibitor_I67 PF11405.8 CDW57864.1 - 0.41 10.9 10.9 0.49 10.7 1.4 2.8 2 0 0 2 2 2 0 Bromelain inhibitor VI NADH_B2 PF14813.6 CDW57865.1 - 6.3e-12 45.1 0.3 9.3e-12 44.6 0.3 1.2 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 EST1_DNA_bind PF10373.9 CDW57866.1 - 7.2e-25 88.0 0.7 7.3e-23 81.4 0.5 2.2 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain PIN_4 PF13638.6 CDW57866.1 - 3.5e-07 30.6 0.3 9e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 PIN domain EST1 PF10374.9 CDW57866.1 - 5.5e-05 23.8 0.0 0.00023 21.8 0.0 2.1 1 0 0 1 1 1 1 Telomerase activating protein Est1 Ribosomal_S11 PF00411.19 CDW57867.1 - 5.3e-25 88.0 0.3 7.6e-25 87.5 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 Myb_Cef PF11831.8 CDW57868.1 - 2.6e-39 135.2 11.7 2.6e-39 135.2 11.7 4.3 4 1 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-bind_6 PF13921.6 CDW57868.1 - 2.4e-19 69.3 6.2 3.6e-12 46.3 3.2 2.9 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CDW57868.1 - 3.2e-19 68.8 6.3 2.6e-10 40.3 1.9 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 CDW57868.1 - 0.89 9.7 11.4 0.47 10.6 0.2 4.1 4 1 0 5 5 5 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain YL1 PF05764.13 CDW57868.1 - 3.1 7.8 29.4 0.75 9.9 0.3 3.3 3 0 0 3 3 3 0 YL1 nuclear protein Pou PF00157.17 CDW57869.1 - 8.6e-38 128.2 0.3 2e-37 127.0 0.3 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 CDW57869.1 - 4e-18 65.0 1.3 9.5e-18 63.8 1.3 1.7 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 CDW57869.1 - 0.014 15.7 0.1 0.11 12.8 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain Cadherin_3 PF16184.5 CDW57870.1 - 5.2e-134 438.6 26.1 1e-16 60.9 0.0 15.1 15 0 0 15 15 15 14 Cadherin-like Laminin_G_2 PF02210.24 CDW57870.1 - 2.7e-13 50.6 0.4 2e-05 25.1 0.0 4.1 3 0 0 3 3 3 2 Laminin G domain Laminin_G_1 PF00054.23 CDW57870.1 - 2.8e-08 34.0 0.0 0.00081 19.6 0.0 3.0 3 0 0 3 3 3 2 Laminin G domain Big_9 PF17963.1 CDW57870.1 - 5.5e-05 23.8 1.3 27 5.6 0.0 6.8 7 0 0 7 7 7 1 Bacterial Ig domain Cadherin_4 PF17803.1 CDW57870.1 - 0.051 14.2 0.2 97 3.7 0.0 4.7 3 0 0 3 3 3 0 Bacterial cadherin-like domain CR6_interact PF10147.9 CDW57871.1 - 3e-29 102.2 13.6 3.5e-29 102.0 13.6 1.0 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF885 PF05960.11 CDW57871.1 - 5.9e-05 22.9 1.8 7e-05 22.7 1.8 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) DUF1741 PF08427.10 CDW57871.1 - 0.031 13.9 1.0 0.051 13.2 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1741) AAA_9 PF12781.7 CDW57871.1 - 1.1 8.3 12.4 4.1 6.5 4.4 2.8 2 1 1 3 3 3 0 ATP-binding dynein motor region TMPIT PF07851.13 CDW57871.1 - 1.5 8.0 6.9 0.19 11.0 3.1 1.3 2 0 0 2 2 2 0 TMPIT-like protein V_ATPase_I PF01496.19 CDW57871.1 - 3.9 5.3 7.2 4.3 5.1 7.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3512 PF12024.8 CDW57872.1 - 2.1e-19 70.0 0.0 5e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) Bromodomain PF00439.25 CDW57872.1 - 3.1e-07 30.4 0.3 7.1e-07 29.2 0.3 1.6 1 0 0 1 1 1 1 Bromodomain PBP1_TM PF14812.6 CDW57872.1 - 0.41 11.1 4.6 0.24 11.8 0.4 2.3 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1713 PF08213.11 CDW57873.1 - 3.8 7.5 24.7 0.17 11.9 19.1 1.7 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1713) TSP_1 PF00090.19 CDW57874.1 - 3.5e-12 46.3 36.2 5.5e-05 23.3 1.9 5.3 5 1 0 5 5 5 3 Thrombospondin type 1 domain CBM_14 PF01607.24 CDW57874.1 - 4.9e-05 23.4 3.4 4.9e-05 23.4 3.4 3.3 3 0 0 3 3 3 1 Chitin binding Peritrophin-A domain SNF5 PF04855.12 CDW57875.1 - 5.9e-57 193.2 0.1 2.3e-29 102.9 0.0 2.2 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 Tubulin PF00091.25 CDW57876.1 - 1.2e-68 231.2 0.0 1.7e-68 230.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDW57876.1 - 2.2e-51 173.3 0.0 3.4e-51 172.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDW57876.1 - 0.0018 18.0 0.0 0.0033 17.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain TFIIB PF00382.19 CDW57877.1 - 1.5e-20 73.0 0.0 1.5e-09 37.8 0.0 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 CDW57877.1 - 3.4e-16 59.4 4.7 3.4e-16 59.4 4.7 2.0 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 CDW57877.1 - 0.0018 17.7 2.9 0.0041 16.6 2.9 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 CDW57877.1 - 0.021 14.5 0.2 1.3 8.8 0.1 2.5 2 0 0 2 2 2 0 Cyclin, N-terminal domain Caldesmon PF02029.15 CDW57877.1 - 0.16 10.7 17.8 0.21 10.3 17.8 1.1 1 0 0 1 1 1 0 Caldesmon YkuI_C PF10388.9 CDW57877.1 - 0.34 10.7 3.9 0.17 11.7 1.5 1.7 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain GTP_EFTU PF00009.27 CDW57878.1 - 3.1e-53 180.2 0.6 3.9e-53 179.9 0.6 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CDW57878.1 - 5.3e-13 49.2 1.4 1.1e-12 48.1 1.4 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 CDW57878.1 - 4.3e-07 30.2 0.0 1.1e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 CDW57878.1 - 6.5e-06 26.2 0.1 1.3e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase zf-C4 PF00105.18 CDW57879.1 - 2.5e-31 107.9 16.0 2.5e-31 107.9 16.0 2.4 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW57880.1 - 4.3e-23 82.0 0.0 9.1e-23 80.9 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor LSDAT_euk PF18139.1 CDW57881.1 - 6.9e-73 245.3 0.0 1.1e-72 244.7 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 CDW57881.1 - 2.9e-14 52.8 0.0 6.1e-14 51.7 0.0 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote RVT_1 PF00078.27 CDW57882.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) dCMP_cyt_deam_1 PF00383.23 CDW57883.1 - 2.4e-18 65.9 0.3 2.8e-18 65.6 0.3 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 CDW57883.1 - 1.2e-12 48.2 0.6 1.3e-10 41.6 0.1 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region Peptidase_C1 PF00112.23 CDW57885.1 - 2.6e-59 201.0 3.3 3.1e-59 200.7 3.3 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 CDW57885.1 - 0.024 14.5 0.0 0.051 13.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 CDW57885.1 - 0.069 11.9 0.9 0.12 11.1 0.0 1.7 2 0 0 2 2 2 0 Peptidase C1-like family Alg6_Alg8 PF03155.15 CDW57886.1 - 6.5e-128 427.7 34.2 8.2e-128 427.4 34.2 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Lig_chan-Glu_bd PF10613.9 CDW57888.1 - 0.0015 18.7 0.0 0.0027 17.9 0.0 1.3 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 CDW57888.1 - 0.0082 15.6 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 MIF4G PF02854.19 CDW57889.1 - 1.8e-11 44.1 0.2 2.8e-11 43.5 0.2 1.2 1 0 0 1 1 1 1 MIF4G domain LRR_8 PF13855.6 CDW57890.1 - 1.9e-14 53.2 8.6 2.9e-09 36.6 0.7 2.8 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CDW57890.1 - 8.9e-10 38.7 9.8 3.7e-05 24.0 1.5 3.4 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CDW57890.1 - 0.024 15.1 9.9 9.4 7.2 1.9 4.4 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.6 CDW57890.1 - 0.03 13.8 0.8 0.048 13.2 0.4 1.5 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 CDW57890.1 - 0.98 9.6 4.2 16 5.9 0.2 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Ldl_recept_a PF00057.18 CDW57891.1 - 4.3e-17 62.0 25.5 7.9e-08 32.4 2.9 3.7 3 0 0 3 3 3 3 Low-density lipoprotein receptor domain class A Fibrinogen_C PF00147.18 CDW57892.1 - 1.8e-35 122.8 4.3 3.3e-19 69.6 3.0 2.1 1 1 1 2 2 2 2 Fibrinogen beta and gamma chains, C-terminal globular domain Lig_chan-Glu_bd PF10613.9 CDW57892.1 - 0.15 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Ligated ion channel L-glutamate- and glycine-binding site DER1 PF04511.15 CDW57893.1 - 1.3e-64 217.7 17.3 2.2e-64 216.9 17.3 1.4 1 0 0 1 1 1 1 Der1-like family PrmA PF06325.13 CDW57893.1 - 1.2e-11 44.6 0.2 1.2e-11 44.6 0.2 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDW57893.1 - 2.2e-07 31.5 0.1 1.4e-06 28.9 0.1 2.6 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 CDW57893.1 - 4.6e-06 26.3 0.1 1.2e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase small domain PRMT5_C PF17286.2 CDW57893.1 - 6.3e-06 26.2 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_23 PF13489.6 CDW57893.1 - 1.8e-05 24.7 0.0 0.00014 21.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW57893.1 - 9.4e-05 22.4 0.1 0.00021 21.3 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW57893.1 - 0.00018 22.1 0.0 0.00056 20.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CDW57893.1 - 0.0019 18.0 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase TPR_2 PF07719.17 CDW57893.1 - 0.0031 17.5 0.1 7.3 7.0 0.0 3.4 3 0 0 3 3 2 1 Tetratricopeptide repeat Methyltransf_12 PF08242.12 CDW57893.1 - 0.0064 17.2 0.7 0.039 14.7 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Pilus_CpaD PF09476.10 CDW57893.1 - 0.032 13.9 0.3 0.065 13.0 0.3 1.5 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) DUF1751 PF08551.10 CDW57893.1 - 0.054 14.1 2.8 0.12 12.9 2.8 1.6 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) Methyltransf_32 PF13679.6 CDW57893.1 - 0.064 13.2 0.1 0.064 13.2 0.1 3.6 3 1 0 3 3 2 0 Methyltransferase domain DUF4407 PF14362.6 CDW57893.1 - 0.14 11.5 19.9 2 7.7 9.8 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TPR_11 PF13414.6 CDW57893.1 - 0.21 11.3 0.0 3.3 7.5 0.0 2.8 3 0 0 3 3 3 0 TPR repeat Methyltransf_31 PF13847.6 CDW57893.1 - 0.34 10.7 3.9 0.58 9.9 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain TolA_bind_tri PF16331.5 CDW57893.1 - 2.4 8.3 20.5 2.9 8.0 2.0 4.5 4 1 0 4 4 4 0 TolA binding protein trimerisation HALZ PF02183.18 CDW57893.1 - 5.5 7.3 12.4 0.42 10.9 2.3 3.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper YabA PF06156.13 CDW57893.1 - 6 7.6 18.8 1.3 9.7 1.4 3.6 2 1 1 4 4 3 0 Initiation control protein YabA WD40 PF00400.32 CDW57894.1 - 2.3e-39 132.7 26.2 1.3e-06 29.0 0.0 10.7 10 0 0 10 10 10 8 WD domain, G-beta repeat Utp13 PF08625.11 CDW57894.1 - 7.4e-35 119.9 0.2 1.4e-34 119.0 0.2 1.5 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 CDW57894.1 - 2.2e-10 40.7 7.8 0.16 12.2 0.0 7.8 4 2 4 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain HBB PF06777.11 CDW57894.1 - 0.07 12.8 0.2 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 Helical and beta-bridge domain LSM PF01423.22 CDW57895.1 - 3e-15 55.6 0.2 4.7e-15 55.0 0.2 1.3 1 0 0 1 1 1 1 LSM domain Vps54_N PF10475.9 CDW57896.1 - 3.5e-12 46.2 0.1 4.6e-12 45.8 0.1 1.2 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex S_4TM PF18159.1 CDW57896.1 - 0.0046 16.3 0.1 0.0052 16.1 0.1 1.0 1 0 0 1 1 1 1 SMODS-associating 4TM effector domain DUF2730 PF10805.8 CDW57896.1 - 0.035 14.2 0.0 2.5 8.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF2451 PF10474.9 CDW57897.1 - 7e-65 219.1 1.6 8.1e-65 218.9 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) GCP_C_terminal PF04130.13 CDW57897.1 - 0.0065 16.0 0.4 0.012 15.1 0.3 1.3 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Rx_N PF18052.1 CDW57897.1 - 0.073 13.4 0.1 13 6.1 0.1 2.6 3 0 0 3 3 3 0 Rx N-terminal domain SH2 PF00017.24 CDW57898.1 - 2.4e-16 59.6 0.5 6e-16 58.3 0.2 1.8 2 0 0 2 2 2 1 SH2 domain Spc7_N PF15402.6 CDW57898.1 - 0.23 9.7 0.0 0.27 9.4 0.0 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Chloroplast_duf PF14476.6 CDW57898.1 - 0.28 10.1 0.4 0.44 9.5 0.4 1.2 1 0 0 1 1 1 0 Petal formation-expressed GCV_H PF01597.19 CDW57900.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage H-protein NDK PF00334.19 CDW57901.1 - 2.1e-18 66.6 0.1 3.1e-18 66.1 0.1 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.13 CDW57901.1 - 3.4e-10 39.4 0.2 5.6e-10 38.7 0.2 1.4 1 0 0 1 1 1 1 Dpy-30 motif Mid1 PF12929.7 CDW57902.1 - 1.3e-05 24.6 0.3 2.1e-05 23.9 0.3 1.2 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Cullin PF00888.22 CDW57904.1 - 3.2e-177 590.9 3.5 4e-177 590.6 3.5 1.1 1 0 0 1 1 1 1 Cullin family LRR_8 PF13855.6 CDW57904.1 - 3.9e-18 65.0 21.9 6e-09 35.5 4.8 3.9 1 1 3 4 4 4 4 Leucine rich repeat Cullin_Nedd8 PF10557.9 CDW57904.1 - 2.8e-15 56.1 0.7 9.2e-15 54.4 0.7 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain LRR_4 PF12799.7 CDW57904.1 - 1.2e-14 54.1 22.6 3.7e-05 24.0 2.2 5.5 3 1 4 7 7 7 6 Leucine Rich repeats (2 copies) HbrB PF08539.11 CDW57904.1 - 8e-05 22.7 0.9 0.00022 21.3 0.9 1.8 1 0 0 1 1 1 1 HbrB-like HGD-D PF06050.13 CDW57904.1 - 0.062 13.1 0.1 0.29 10.8 0.0 2.1 3 0 0 3 3 3 0 2-hydroxyglutaryl-CoA dehydratase, D-component LRR_1 PF00560.33 CDW57904.1 - 1 10.1 20.8 16 6.5 0.5 7.3 7 0 0 7 7 7 0 Leucine Rich Repeat UQ_con PF00179.26 CDW57905.1 - 3e-16 59.4 0.0 3.4e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ABC_tran PF00005.27 CDW57906.1 - 4.1e-57 192.5 0.0 1.1e-31 110.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CDW57906.1 - 1.9e-12 47.4 6.7 1.1e-05 25.2 0.5 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CDW57906.1 - 2.4e-10 40.2 0.4 0.001 18.5 0.0 4.2 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDW57906.1 - 8.2e-07 29.6 0.1 0.054 13.9 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CDW57906.1 - 4.3e-06 26.4 0.1 0.055 13.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CDW57906.1 - 8.7e-06 26.1 0.1 0.046 14.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CDW57906.1 - 1.2e-05 25.3 0.1 0.039 13.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 CDW57906.1 - 3.7e-05 23.7 0.0 0.73 9.6 0.1 3.9 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CDW57906.1 - 0.00026 21.1 0.5 0.072 13.2 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_7 PF12775.7 CDW57906.1 - 0.00034 20.2 0.1 0.9 9.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_30 PF13604.6 CDW57906.1 - 0.00034 20.4 0.1 0.4 10.4 0.0 2.9 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.17 CDW57906.1 - 0.00072 19.7 0.2 0.49 10.4 0.1 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain cobW PF02492.19 CDW57906.1 - 0.00083 19.0 1.2 0.012 15.3 0.1 2.6 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 CDW57906.1 - 0.0016 19.0 0.1 3.1 8.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATP-synt_ab PF00006.25 CDW57906.1 - 0.0024 17.6 0.0 0.63 9.7 0.0 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 CDW57906.1 - 0.004 16.3 0.0 0.063 12.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rad17 PF03215.15 CDW57906.1 - 0.0043 17.0 0.2 0.043 13.7 0.0 2.5 3 0 0 3 3 2 1 Rad17 P-loop domain FtsK_SpoIIIE PF01580.18 CDW57906.1 - 0.0046 16.3 0.1 0.27 10.6 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 CDW57906.1 - 0.0047 17.0 0.0 4 7.5 0.0 2.4 2 0 0 2 2 2 2 Dynamin family AAA_15 PF13175.6 CDW57906.1 - 0.0084 15.9 0.0 3.6 7.2 0.0 2.6 3 1 0 3 3 2 1 AAA ATPase domain TrwB_AAD_bind PF10412.9 CDW57906.1 - 0.011 14.7 0.2 1.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 CDW57906.1 - 0.011 16.1 0.0 2.2 8.7 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_PrkA PF08298.11 CDW57906.1 - 0.014 14.3 0.0 2.4 7.0 0.0 2.3 2 0 0 2 2 2 0 PrkA AAA domain TsaE PF02367.17 CDW57906.1 - 0.016 15.2 0.1 0.69 9.9 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 CDW57906.1 - 0.022 14.8 0.3 7.6 6.5 0.0 3.6 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) Guanylate_kin PF00625.21 CDW57906.1 - 0.026 14.2 0.1 0.28 10.9 0.1 2.3 2 0 0 2 2 2 0 Guanylate kinase Zeta_toxin PF06414.12 CDW57906.1 - 0.037 13.3 0.1 5.9 6.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_10 PF12846.7 CDW57906.1 - 0.039 12.9 0.1 0.97 8.3 0.1 2.2 2 0 0 2 2 2 0 AAA-like domain T2SSE PF00437.20 CDW57906.1 - 0.058 12.4 0.2 0.44 9.6 0.0 2.3 2 1 0 2 2 2 0 Type II/IV secretion system protein NB-ARC PF00931.22 CDW57906.1 - 0.065 12.4 1.3 5.8 6.0 0.1 3.0 3 0 0 3 3 3 0 NB-ARC domain Roc PF08477.13 CDW57906.1 - 0.072 13.3 0.1 23 5.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 CDW57906.1 - 0.076 13.6 0.0 8.2 7.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CDW57906.1 - 0.26 11.6 1.1 11 6.3 0.0 3.0 3 1 0 3 3 2 0 AAA domain Myb_DNA-bind_7 PF15963.5 CDW57908.1 - 5.3e-20 71.1 0.3 1.1e-19 70.1 0.3 1.5 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 CDW57908.1 - 1e-05 25.6 0.0 1.9e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF2576 PF10845.8 CDW57908.1 - 0.0061 16.1 0.4 0.033 13.8 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2576) APC_u14 PF16635.5 CDW57908.1 - 0.063 13.8 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr DEAD PF00270.29 CDW57909.1 - 9.7e-42 142.7 0.0 1.2e-40 139.1 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW57909.1 - 1.7e-29 102.4 0.0 3.1e-29 101.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 CDW57909.1 - 0.0061 15.8 0.0 0.0096 15.2 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 CDW57909.1 - 0.0061 15.9 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Glyco_transf_10 PF00852.19 CDW57910.1 - 1.1e-52 178.4 2.5 1.5e-52 177.9 2.5 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW57910.1 - 1.2e-23 83.6 1.4 2.7e-23 82.6 0.1 2.2 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal IL11 PF07400.11 CDW57910.1 - 0.062 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Interleukin 11 HCBP_related PF06594.11 CDW57910.1 - 0.073 13.0 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain Glycos_transf_2 PF00535.26 CDW57911.1 - 1.6e-22 80.1 0.0 3.5e-22 79.0 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CDW57911.1 - 2.7e-06 27.5 0.0 3.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 SelP_N PF04592.14 CDW57912.1 - 8.4e-24 84.3 0.0 1.5e-23 83.4 0.0 1.4 1 0 0 1 1 1 1 Selenoprotein P, N terminal region DUF3767 PF12597.8 CDW57913.1 - 5.6e-05 22.9 0.1 6.9e-05 22.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) DUF2129 PF09902.9 CDW57913.1 - 0.031 14.4 0.3 0.046 13.8 0.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2129) Pkinase PF00069.25 CDW57914.1 - 2e-64 217.5 0.0 4.4e-64 216.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW57914.1 - 2.9e-36 125.1 0.0 4.9e-36 124.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 CDW57914.1 - 5.8e-16 58.4 14.5 6.2e-07 29.4 0.5 4.2 3 1 0 3 3 3 3 Hr1 repeat Pkinase_C PF00433.24 CDW57914.1 - 8e-10 39.3 3.7 1.9e-09 38.1 3.7 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 CDW57914.1 - 1.7e-05 24.3 0.0 3.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Thg1 PF04446.12 CDW57914.1 - 0.081 13.0 1.1 31 4.6 0.0 3.6 3 1 1 4 4 4 0 tRNAHis guanylyltransferase DUF4061 PF13270.6 CDW57914.1 - 0.79 10.1 5.7 0.89 9.9 0.0 3.6 3 1 2 5 5 5 0 Domain of unknown function (DUF4061) DUF724 PF05266.14 CDW57914.1 - 7.5 6.3 7.7 1.6 8.6 3.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) LBP_BPI_CETP_C PF02886.17 CDW57915.1 - 5.9e-25 88.1 0.2 9.5e-25 87.4 0.2 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain Mtp PF03821.16 CDW57917.1 - 9.9e-19 67.9 11.7 1.3e-10 41.3 1.0 2.2 1 1 1 2 2 2 2 Golgi 4-transmembrane spanning transporter DUF4728 PF15860.5 CDW57917.1 - 0.00018 22.1 12.1 0.082 13.6 12.1 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4728) Peptidase_M28 PF04389.17 CDW57918.1 - 7.6e-14 51.9 0.0 1.1e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 CDW57918.1 - 1.5e-06 27.9 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Nicastrin Ac110_PIF PF07280.11 CDW57918.1 - 0.099 12.4 0.1 0.099 12.4 0.1 2.0 2 0 0 2 2 2 0 Per os infectivity factor AC110 ANF_receptor PF01094.28 CDW57919.1 - 5.3e-73 246.1 0.0 8.3e-73 245.5 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 CDW57919.1 - 1.3e-49 169.1 28.8 1.3e-49 169.1 28.8 2.2 3 0 0 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 CDW57919.1 - 8.2e-11 41.7 11.6 2.2e-10 40.3 11.6 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 CDW57919.1 - 3.2e-09 36.9 0.0 7.7e-09 35.7 0.0 1.5 2 0 0 2 2 2 1 Periplasmic binding protein Na_Ala_symp PF01235.17 CDW57919.1 - 0.0015 17.9 8.4 0.0032 16.8 8.4 1.5 1 0 0 1 1 1 1 Sodium:alanine symporter family Spo12 PF05032.12 CDW57920.1 - 2.6e-06 27.2 0.1 5.6e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 Spo12 family MIF4G_like_2 PF09090.11 CDW57922.1 - 8.3e-36 123.8 0.0 1.3e-35 123.2 0.0 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.11 CDW57922.1 - 4.8e-28 98.2 0.1 9.4e-28 97.3 0.1 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 CDW57922.1 - 3.5e-05 23.6 1.4 8.8e-05 22.2 1.4 1.8 1 0 0 1 1 1 1 MIF4G domain DUF5337 PF17272.2 CDW57923.1 - 0.021 14.6 0.0 0.031 14.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5337) DUF4307 PF14155.6 CDW57923.1 - 0.078 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) DUF3377 PF11857.8 CDW57923.1 - 0.25 11.3 1.8 0.4 10.6 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Sigma_reg_N PF13800.6 CDW57923.1 - 1.2 9.4 5.5 13 6.1 4.3 2.1 1 1 1 2 2 2 0 Sigma factor regulator N-terminal DUF2970 PF11174.8 CDW57923.1 - 1.6 8.6 9.3 5.2 7.0 9.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2970) Ribosomal_S13 PF00416.22 CDW57924.1 - 3.6e-54 182.6 1.2 4.2e-54 182.4 1.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Hep_59 PF07052.11 CDW57925.1 - 6.5e-24 84.7 5.0 7.6e-24 84.5 0.2 2.4 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 BAR PF03114.18 CDW57926.1 - 6.1e-68 229.0 7.4 7.4e-68 228.7 7.4 1.0 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 CDW57926.1 - 2.5e-07 30.1 2.4 2.5e-07 30.1 2.4 1.3 1 1 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 CDW57926.1 - 3.3e-06 27.0 4.0 1e-05 25.4 4.0 1.8 1 1 0 1 1 1 1 BAR domain of APPL family Not3 PF04065.15 CDW57926.1 - 0.028 13.9 1.5 0.65 9.4 0.1 2.4 2 1 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Takusan PF04822.13 CDW57926.1 - 0.039 13.8 6.1 0.72 9.8 0.2 3.0 3 2 0 3 3 3 0 Takusan Nckap1 PF09735.9 CDW57926.1 - 0.04 11.9 1.4 0.062 11.3 1.4 1.2 1 0 0 1 1 1 0 Membrane-associated apoptosis protein ADK PF00406.22 CDW57927.1 - 3.6e-52 176.5 0.1 4.5e-52 176.2 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDW57927.1 - 6.7e-34 117.2 0.1 1e-33 116.6 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDW57927.1 - 1.5e-07 31.7 0.0 5.2e-07 29.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CDW57927.1 - 9.3e-05 22.2 0.7 0.33 10.6 0.1 2.1 2 0 0 2 2 2 2 Thymidylate kinase AAA_18 PF13238.6 CDW57927.1 - 0.00019 22.0 0.0 0.00028 21.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Ploopntkinase3 PF18751.1 CDW57927.1 - 0.004 17.1 0.1 0.0085 16.0 0.0 1.6 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 AAA_19 PF13245.6 CDW57927.1 - 0.0056 17.0 1.6 0.036 14.4 1.6 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CDW57927.1 - 0.017 15.5 0.4 0.14 12.6 0.4 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 CDW57927.1 - 0.046 13.3 0.2 0.072 12.7 0.0 1.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CDW57927.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain Cob_adeno_trans PF01923.18 CDW57927.1 - 0.11 12.6 0.2 4.1 7.5 0.1 2.1 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Zeta_toxin PF06414.12 CDW57927.1 - 0.17 11.1 1.6 0.8 8.9 0.1 2.2 2 1 0 2 2 2 0 Zeta toxin ADK PF00406.22 CDW57928.1 - 1e-08 35.4 0.1 0.0001 22.4 0.1 2.3 1 1 1 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 CDW57928.1 - 0.00045 20.7 0.0 0.0017 18.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain DSHCT PF08148.12 CDW57929.1 - 7.4e-15 55.0 1.3 2.6e-14 53.2 0.5 2.3 2 1 1 3 3 3 1 DSHCT (NUC185) domain DEAD PF00270.29 CDW57929.1 - 2e-09 37.4 0.0 2.4e-08 34.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW57929.1 - 2e-06 28.1 0.0 9.5e-06 25.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Ski2_N PF17911.1 CDW57932.1 - 9.9e-10 38.3 0.0 1.4e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Ski2 N-terminal region tRNA-synt_2b PF00587.25 CDW57933.1 - 0.0016 18.4 0.0 0.0028 17.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Sigma70_r4_2 PF08281.12 CDW57933.1 - 0.067 12.9 0.5 0.2 11.3 0.1 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 Seryl_tRNA_N PF02403.22 CDW57933.1 - 0.1 12.8 2.4 0.37 11.0 2.4 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TANGO2 PF05742.12 CDW57933.1 - 0.15 12.1 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Transport and Golgi organisation 2 tRNA-synt_His PF13393.6 CDW57933.1 - 0.18 11.1 0.1 15 4.7 0.0 2.3 2 0 0 2 2 2 0 Histidyl-tRNA synthetase RasGEF PF00617.19 CDW57934.1 - 2.6e-50 171.1 0.9 5.4e-50 170.0 0.7 1.6 1 1 0 1 1 1 1 RasGEF domain SRP19 PF01922.17 CDW57935.1 - 5.8e-25 88.1 0.0 7.3e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 SRP19 protein UQ_con PF00179.26 CDW57936.1 - 1.9e-44 150.7 0.0 2.2e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDW57936.1 - 0.062 13.6 0.1 0.11 12.8 0.1 1.6 1 1 0 1 1 1 0 RWD domain Calreticulin PF00262.18 CDW57937.1 - 2.1e-83 280.2 16.4 2.4e-61 207.6 4.8 3.1 2 1 1 3 3 3 2 Calreticulin family MDM10 PF12519.8 CDW57937.1 - 0.018 14.0 0.8 0.39 9.5 2.2 2.0 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 NARP1 PF12569.8 CDW57937.1 - 8.5 5.2 13.7 16 4.3 13.7 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 ABC_tran PF00005.27 CDW57938.1 - 3.8e-22 79.3 0.0 5.8e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 CDW57938.1 - 2.2e-17 63.2 25.0 6.5e-16 58.4 21.3 2.9 2 1 0 2 2 2 1 ABC-2 type transporter RsgA_GTPase PF03193.16 CDW57938.1 - 0.00066 19.6 0.1 0.0012 18.8 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase NTPase_1 PF03266.15 CDW57938.1 - 0.0011 18.9 0.0 0.024 14.5 0.1 2.2 2 0 0 2 2 2 1 NTPase AAA_21 PF13304.6 CDW57938.1 - 0.002 18.0 0.1 1.3 8.7 0.6 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 CDW57938.1 - 0.0023 18.3 0.0 0.004 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 CDW57938.1 - 0.005 16.9 0.3 0.013 15.5 0.3 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 CDW57938.1 - 0.0086 16.3 0.0 0.038 14.2 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_25 PF13481.6 CDW57938.1 - 0.011 15.3 0.1 0.046 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CDW57938.1 - 0.029 14.9 0.1 0.049 14.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CDW57938.1 - 0.038 13.7 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_28 PF13521.6 CDW57938.1 - 0.068 13.4 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain S4 PF01479.25 CDW57938.1 - 0.07 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 S4 domain AAA_29 PF13555.6 CDW57938.1 - 0.076 12.8 1.4 0.087 12.6 0.0 1.8 2 0 0 2 2 1 0 P-loop containing region of AAA domain cobW PF02492.19 CDW57938.1 - 0.14 11.7 0.2 0.23 11.0 0.2 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 CDW57938.1 - 0.14 11.8 0.0 0.51 10.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 CDW57938.1 - 0.16 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 CDW57938.1 - 0.17 12.4 0.1 0.33 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 CDW57938.1 - 0.21 11.1 0.1 0.38 10.3 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B RB_A PF01858.17 CDW57939.1 - 8.4e-05 22.5 0.2 0.00012 22.0 0.2 1.2 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain SMC_Nse1 PF07574.13 CDW57939.1 - 9e-05 22.5 1.5 0.036 14.0 0.3 2.1 1 1 1 2 2 2 2 Nse1 non-SMC component of SMC5-6 complex C1_1 PF00130.22 CDW57939.1 - 0.00036 20.3 6.5 0.001 18.9 6.5 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 CDW57939.1 - 0.0005 20.1 3.6 0.0015 18.6 3.6 1.8 1 0 0 1 1 1 1 KIAA1045 RING finger Zn_ribbon_17 PF17120.5 CDW57939.1 - 0.0083 15.7 6.7 0.0083 15.7 6.7 1.7 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 CDW57939.1 - 0.077 13.3 10.0 0.16 12.3 10.0 1.6 1 0 0 1 1 1 0 Ring finger domain DUF2666 PF10869.8 CDW57939.1 - 0.13 12.5 0.6 0.23 11.7 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) zf-RING-like PF08746.11 CDW57939.1 - 1 9.7 10.3 1.8 9.0 9.3 2.0 2 0 0 2 2 2 0 RING-like domain zf-RING_9 PF13901.6 CDW57939.1 - 3.5 7.5 12.5 0.96 9.4 7.4 2.1 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon Mito_carr PF00153.27 CDW57940.1 - 3.2e-44 148.8 1.3 8.7e-17 60.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3493 PF11998.8 CDW57940.1 - 0.49 10.6 2.7 14 6.0 0.2 3.3 2 1 1 3 3 3 0 Low psii accumulation1 / Rep27 DBR1 PF05011.13 CDW57941.1 - 5.8e-27 94.8 0.1 1e-26 94.0 0.1 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos_2 PF12850.7 CDW57941.1 - 0.052 13.7 0.0 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain MethyTransf_Reg PF10119.9 CDW57941.1 - 0.13 13.0 0.0 0.26 12.0 0.0 1.6 1 0 0 1 1 1 0 Predicted methyltransferase regulatory domain WD40 PF00400.32 CDW57942.1 - 2.1e-25 88.5 22.8 0.00013 22.6 0.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW57942.1 - 5.7e-06 26.6 0.8 0.015 15.6 0.1 3.9 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 CDW57943.1 - 6.2e-06 26.7 0.8 8.6e-06 26.2 0.1 1.6 2 0 0 2 2 2 1 NLE (NUC135) domain RRM_1 PF00076.22 CDW57944.1 - 6.6e-14 51.5 0.5 1e-13 50.9 0.1 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW57944.1 - 0.00049 19.7 0.1 0.001 18.7 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDW57944.1 - 0.047 13.7 0.2 0.12 12.4 0.1 1.7 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 CDW57944.1 - 0.075 13.3 0.3 0.31 11.2 0.0 2.0 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Keratin_B2 PF01500.17 CDW57945.1 - 0.47 10.4 11.9 0.033 14.2 5.8 2.2 2 1 1 3 3 3 0 Keratin, high sulfur B2 protein PID_2 PF14719.6 CDW57947.1 - 0.0026 17.6 0.0 2.4 8.0 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) DEC-1_C PF04626.13 CDW57947.1 - 0.082 13.3 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Dec-1 protein, C terminal region L51_S25_CI-B8 PF05047.16 CDW57948.1 - 1.5e-07 31.2 0.1 3.2e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF4457 PF14652.6 CDW57951.1 - 0.07 12.4 0.0 0.074 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) Peptidase_M14 PF00246.24 CDW57952.1 - 2.5e-74 250.7 0.0 3e-74 250.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 CDW57952.1 - 0.00011 22.5 0.1 0.00027 21.2 0.1 1.6 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Thioredoxin_8 PF13905.6 CDW57953.1 - 1.1e-21 76.9 0.0 5.6e-17 61.9 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 CDW57953.1 - 3.3e-05 23.6 0.0 6.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CDW57953.1 - 0.00045 20.1 0.0 0.0014 18.5 0.0 1.8 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_6 PF13848.6 CDW57953.1 - 0.011 15.7 0.1 0.022 14.7 0.1 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDW57953.1 - 0.016 15.6 0.0 0.18 12.3 0.0 2.4 2 1 0 2 2 2 0 Thioredoxin-like domain Thioredoxin PF00085.20 CDW57953.1 - 0.039 14.0 0.2 0.29 11.1 0.0 2.5 4 0 0 4 4 4 0 Thioredoxin Homeodomain PF00046.29 CDW57954.1 - 5.1e-21 74.3 3.0 8.5e-21 73.6 3.0 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW57954.1 - 0.014 15.3 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain KAR9 PF08580.10 CDW57954.1 - 9.3 4.7 9.5 11 4.4 9.5 1.2 1 0 0 1 1 1 0 Yeast cortical protein KAR9 Clc-like PF07062.12 CDW57955.1 - 1.8e-30 106.0 16.3 4.9e-29 101.3 16.3 2.0 1 1 0 1 1 1 1 Clc-like Claudin_3 PF06653.11 CDW57955.1 - 4.8e-07 29.9 8.6 0.00057 19.9 5.0 2.3 2 0 0 2 2 2 2 Tight junction protein, Claudin-like Sensor PF13796.6 CDW57955.1 - 0.00062 19.8 7.1 0.0068 16.5 0.8 2.5 2 1 0 2 2 2 2 Putative sensor DuoxA PF10204.9 CDW57955.1 - 0.16 11.0 10.7 0.019 14.0 5.8 1.8 2 0 0 2 2 2 0 Dual oxidase maturation factor DUF443 PF04276.12 CDW57955.1 - 1.5 8.6 5.3 0.24 11.2 1.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF443) Clc-like PF07062.12 CDW57956.1 - 0.0031 17.0 8.3 0.18 11.3 0.2 2.2 2 0 0 2 2 2 2 Clc-like CRAL_TRIO PF00650.20 CDW57957.1 - 6.3e-18 65.0 0.1 9.9e-18 64.4 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDW57957.1 - 0.014 15.5 0.1 0.033 14.3 0.1 1.7 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain SMI1_KNR4 PF09346.10 CDW57957.1 - 0.18 12.2 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) SMN PF06003.12 CDW57958.1 - 6.6e-14 51.8 14.0 3.6e-08 33.0 2.6 3.2 1 1 2 3 3 3 3 Survival motor neuron protein (SMN) tRNA-synt_1 PF00133.22 CDW57959.1 - 1.1e-141 473.1 0.0 1.5e-141 472.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDW57959.1 - 2.3e-22 79.3 1.3 1.4e-14 53.7 0.0 4.1 4 1 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CDW57959.1 - 2.4e-19 69.8 0.0 4.1e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CDW57959.1 - 0.074 12.4 0.0 8.5 5.6 0.1 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain CaMBD PF02888.16 CDW57960.1 - 3.3e-23 81.7 2.4 9.1e-23 80.2 2.4 1.8 1 0 0 1 1 1 1 Calmodulin binding domain Ion_trans_2 PF07885.16 CDW57960.1 - 2.1e-13 50.0 4.6 2.1e-13 50.0 4.6 2.2 2 0 0 2 2 2 1 Ion channel SK_channel PF03530.14 CDW57960.1 - 6.8e-10 38.9 5.3 0.00012 22.0 0.2 3.2 2 1 1 3 3 3 2 Calcium-activated SK potassium channel TraS PF10624.9 CDW57960.1 - 0.003 17.5 0.4 0.0077 16.2 0.4 1.6 1 0 0 1 1 1 1 Plasmid conjugative transfer entry exclusion protein TraS Lig_chan PF00060.26 CDW57960.1 - 0.15 11.9 3.8 0.29 11.0 2.8 1.9 1 1 0 1 1 1 0 Ligand-gated ion channel DUF1282 PF06930.12 CDW57960.1 - 0.36 10.6 5.8 0.43 10.3 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1282) IRK PF01007.20 CDW57960.1 - 1.7 8.5 8.0 1.2 8.9 4.7 2.4 3 1 0 3 3 3 0 Inward rectifier potassium channel transmembrane domain DUF3378 PF11858.8 CDW57961.1 - 0.1 12.8 0.1 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3378) AA_permease PF00324.21 CDW57962.1 - 7.2e-60 202.9 29.5 1.2e-37 129.6 5.9 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 CDW57962.1 - 1.4e-41 142.9 3.4 8.8e-26 90.9 0.7 2.9 1 1 1 2 2 2 2 Solute carrier family 12 CHCH PF06747.13 CDW57963.1 - 7.6e-06 25.9 5.0 1e-05 25.5 5.0 1.2 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.9 CDW57963.1 - 2.7e-05 24.3 1.5 3.2e-05 24.1 1.5 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) RskA PF10099.9 CDW57963.1 - 0.0021 18.4 4.0 0.0023 18.2 4.0 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA Cmc1 PF08583.10 CDW57963.1 - 0.055 13.5 1.5 0.08 13.0 1.5 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Proteasome PF00227.26 CDW57964.1 - 2.4e-43 147.9 0.0 3.2e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CDW57964.1 - 6.4e-14 51.3 0.1 1.1e-13 50.6 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SGTA_dimer PF16546.5 CDW57964.1 - 0.075 12.8 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Homodimerisation domain of SGTA HD_4 PF13328.6 CDW57964.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 HD domain DEAD PF00270.29 CDW57965.1 - 2.7e-19 69.6 0.3 1.4e-18 67.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDW57965.1 - 0.00047 20.2 1.0 0.0027 17.7 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 CDW57965.1 - 0.053 13.0 2.1 0.5 9.8 0.0 2.1 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain MFS_1 PF07690.16 CDW57966.1 - 2.3e-12 46.5 17.1 2.3e-12 46.5 17.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW57966.1 - 0.00045 19.2 1.7 0.00045 19.2 1.7 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter Helicase_C PF00271.31 CDW57967.1 - 6.4e-31 107.0 0.1 3.5e-30 104.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW57967.1 - 1.7e-19 70.3 0.9 4.5e-19 68.9 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase UTP25 PF06862.12 CDW57967.1 - 0.0018 17.1 2.6 0.01 14.6 0.0 2.6 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 CDW57967.1 - 0.05 13.9 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain RsbU_N PF08673.10 CDW57967.1 - 3.5 7.8 5.7 3.6 7.7 1.8 2.7 3 0 0 3 3 3 0 Phosphoserine phosphatase RsbU, N-terminal domain DnaJ PF00226.31 CDW57968.1 - 7e-08 32.5 0.2 1.6e-07 31.3 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain JAKMIP_CC3 PF16034.5 CDW57969.1 - 0.00043 20.3 13.9 0.00043 20.3 13.9 4.9 1 1 2 4 4 4 3 JAKMIP CC3 domain FUSC PF04632.12 CDW57969.1 - 2.6 6.5 8.0 1.1 7.7 0.9 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family Acetyltransf_11 PF13720.6 CDW57969.1 - 4.7 7.7 7.0 4.2 7.9 2.2 3.4 2 1 1 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 HalX PF08663.10 CDW57969.1 - 6.4 7.2 9.4 0.44 10.9 1.5 3.0 2 0 0 2 2 2 0 HalX domain Histone PF00125.24 CDW57970.1 - 7.9e-54 181.5 1.5 8.7e-54 181.4 1.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW57970.1 - 0.00015 22.3 2.4 0.00019 22.0 2.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW57970.1 - 0.0002 21.4 0.2 0.00042 20.4 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW57970.1 - 0.00028 21.2 0.0 0.00042 20.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW57970.1 - 0.0043 17.3 0.0 0.0083 16.4 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDW57970.1 - 0.06 13.4 0.1 0.11 12.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit RasGAP PF00616.19 CDW57971.1 - 2e-25 89.7 1.8 2e-19 70.1 0.1 3.1 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 CDW57971.1 - 1.6e-22 80.1 4.0 5.4e-22 78.4 0.1 3.7 4 1 0 4 4 4 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 CDW57971.1 - 0.0097 15.6 3.5 0.028 14.1 0.2 3.5 4 0 0 4 4 4 1 CRAL/TRIO domain bZIP_1 PF00170.21 CDW57972.1 - 1.9e-10 40.7 10.9 2.5e-10 40.3 10.9 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CDW57972.1 - 4.9e-05 23.3 8.3 7.1e-05 22.8 8.3 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CDW57972.1 - 0.0036 17.8 5.2 0.0043 17.5 5.2 1.1 1 0 0 1 1 1 1 bZIP Maf transcription factor Tetraspanin PF00335.20 CDW57972.1 - 0.0053 16.5 0.0 0.0062 16.3 0.0 1.0 1 0 0 1 1 1 1 Tetraspanin family Transket_pyr PF02779.24 CDW57973.1 - 2e-67 226.3 0.0 3.1e-67 225.7 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 CDW57973.1 - 5.5e-54 182.0 0.0 1e-53 181.1 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal E1_dh PF00676.20 CDW57973.1 - 5.9e-50 169.9 0.0 1.1e-49 169.0 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component 2-oxogl_dehyd_N PF16078.5 CDW57973.1 - 2.8e-16 58.8 1.0 1.8e-15 56.2 0.3 2.4 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus PFOR_II PF17147.4 CDW57973.1 - 0.009 16.3 0.6 0.028 14.7 0.0 2.1 3 0 0 3 3 3 1 Pyruvate:ferredoxin oxidoreductase core domain II Fer2_3 PF13085.6 CDW57974.1 - 4.3e-27 94.3 0.0 6.4e-27 93.7 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 CDW57974.1 - 3.2e-10 40.4 1.1 5.8e-10 39.6 1.1 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDW57974.1 - 2.1e-08 34.5 3.8 2.7e-07 30.9 3.7 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDW57974.1 - 3.1e-07 30.4 1.4 5.9e-07 29.5 1.4 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDW57974.1 - 0.0016 19.0 7.8 0.011 16.3 8.3 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDW57974.1 - 0.0035 17.5 4.0 0.0035 17.5 4.0 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.6 CDW57974.1 - 0.0045 17.2 2.6 0.65 10.2 0.0 2.5 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDW57974.1 - 0.007 17.3 2.7 2.6 9.0 0.8 2.4 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_4 PF12800.7 CDW57974.1 - 0.19 12.3 8.5 5.8 7.7 2.3 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4 PF00037.27 CDW57974.1 - 0.36 10.7 13.7 0.49 10.3 0.5 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 CDW57974.1 - 3.2 8.0 11.3 0.53 10.5 0.5 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain FAD_binding_2 PF00890.24 CDW57975.1 - 2.3e-118 395.9 5.9 2.8e-118 395.6 5.9 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CDW57975.1 - 1.8e-35 121.7 0.1 2.9e-35 121.0 0.1 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 CDW57975.1 - 0.00012 21.4 2.3 0.0027 17.0 0.8 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDW57975.1 - 0.0002 20.5 3.0 0.0019 17.3 0.9 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 CDW57975.1 - 0.0046 15.7 3.3 0.0046 15.7 0.1 2.4 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 CDW57975.1 - 0.016 14.8 5.9 0.33 10.5 5.7 2.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 CDW57975.1 - 0.038 13.2 0.2 0.85 8.8 0.1 2.2 2 0 0 2 2 2 0 Thi4 family Citrate_synt PF00285.21 CDW57976.1 - 1.1e-131 439.3 0.0 1.2e-131 439.1 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Fimbrial PF00419.20 CDW57977.1 - 2.8e-23 82.9 1.1 3.4e-23 82.6 1.1 1.1 1 0 0 1 1 1 1 Fimbrial protein Usher PF00577.20 CDW57978.1 - 2.9e-189 630.5 19.2 3.7e-189 630.1 19.2 1.1 1 0 0 1 1 1 1 Outer membrane usher protein PapC_N PF13954.6 CDW57978.1 - 1.5e-33 115.8 0.1 3.3e-33 114.8 0.1 1.6 1 0 0 1 1 1 1 PapC N-terminal domain PapC_C PF13953.6 CDW57978.1 - 1.5e-12 47.2 0.2 5.9e-12 45.2 0.0 2.1 2 0 0 2 2 2 1 PapC C-terminal domain Big_6 PF17936.1 CDW57978.1 - 0.062 13.6 0.1 0.25 11.6 0.1 2.0 1 0 0 1 1 1 0 Bacterial Ig domain PapD_N PF00345.20 CDW57979.1 - 1.7e-34 118.4 0.9 2.9e-34 117.6 0.2 1.7 2 0 0 2 2 2 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain PapD_C PF02753.17 CDW57979.1 - 3e-12 46.7 0.4 1.1e-11 44.9 0.4 2.0 1 0 0 1 1 1 1 Pili assembly chaperone PapD, C-terminal domain Fimbrial PF00419.20 CDW57979.1 - 6.5e-06 26.5 0.0 2.8e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 Fimbrial protein ETF_QO PF05187.13 CDW57979.1 - 0.014 15.5 0.1 0.036 14.2 0.1 1.6 1 0 0 1 1 1 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S AbrB PF05145.12 CDW57980.1 - 6.4e-95 317.7 42.9 7.1e-95 317.6 42.9 1.0 1 0 0 1 1 1 1 Transition state regulatory protein AbrB Fapy_DNA_glyco PF01149.24 CDW57981.1 - 5.8e-11 43.0 0.0 8.1e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain CT_A_B PF02626.15 CDW57982.1 - 1.3e-95 320.0 0.0 2.3e-95 319.2 0.0 1.4 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B LamB_YcsF PF03746.16 CDW57982.1 - 8.3e-93 310.5 0.7 1.3e-92 309.8 0.7 1.3 1 0 0 1 1 1 1 LamB/YcsF family CT_C_D PF02682.16 CDW57982.1 - 5.1e-69 232.1 0.0 8.2e-69 231.4 0.0 1.3 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D NIF3 PF01784.18 CDW57982.1 - 5.7e-56 189.9 0.0 9e-56 189.2 0.0 1.3 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) PTR2 PF00854.21 CDW57983.1 - 1.5e-96 323.7 15.4 1.7e-96 323.5 15.4 1.0 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 CDW57983.1 - 3.3e-17 62.4 38.2 5.8e-16 58.4 38.2 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3094 PF11293.8 CDW57983.1 - 0.25 11.1 0.9 1.2 8.9 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF3290 PF11694.8 CDW57983.1 - 1.2 9.1 3.7 0.61 10.1 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) FAD_binding_7 PF03441.14 CDW57984.1 - 3.1e-78 261.9 4.4 5.8e-78 261.0 4.4 1.4 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CDW57984.1 - 7.8e-47 159.3 0.3 2e-46 158.0 0.2 1.7 2 0 0 2 2 2 1 DNA photolyase RHS_repeat PF05593.14 CDW57985.1 - 1.2e-66 220.5 105.4 5.1e-09 36.5 1.2 18.6 18 2 2 20 20 20 13 RHS Repeat DUF4329 PF14220.6 CDW57985.1 - 1.1e-22 80.2 0.2 4.2e-22 78.3 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4329) DDE_Tnp_1 PF01609.21 CDW57985.1 - 1.6e-16 60.6 0.2 4.7e-16 59.1 0.2 1.8 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_assoc PF13808.6 CDW57985.1 - 3.3e-15 55.9 0.0 8.5e-15 54.6 0.0 1.7 1 0 0 1 1 1 1 DDE_Tnp_1-associated RHS PF03527.14 CDW57985.1 - 6.6e-15 54.6 2.7 2.3e-13 49.6 0.2 3.6 3 0 0 3 3 3 1 RHS protein Imm-NTF2-2 PF15631.6 CDW57985.1 - 2e-11 44.0 0.1 5.4e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 NTF2 fold immunity protein UPF0257 PF06788.13 CDW57985.1 - 0.59 9.9 5.7 18 5.1 0.3 4.0 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0257) GST_N_3 PF13417.6 CDW57986.1 - 3.9e-13 49.6 0.0 6.4e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CDW57986.1 - 4.3e-11 42.9 0.0 5.8e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CDW57986.1 - 1.2e-09 38.3 0.0 2.2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CDW57986.1 - 5.9e-08 33.0 0.0 1.6e-07 31.6 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain SelA PF03841.13 CDW57987.1 - 2e-181 602.9 0.0 2.4e-181 602.6 0.0 1.0 1 0 0 1 1 1 1 L-seryl-tRNA selenium transferase Se-cys_synth_N PF12390.8 CDW57987.1 - 3.3e-09 36.8 0.6 3.3e-09 36.8 0.6 2.7 3 0 0 3 3 3 1 Selenocysteine synthase N terminal Aminotran_5 PF00266.19 CDW57987.1 - 0.0031 16.5 0.2 0.0075 15.3 0.2 1.5 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CDW57987.1 - 0.023 13.3 0.0 0.035 12.6 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CDW57987.1 - 0.034 13.5 0.8 0.23 10.7 0.8 2.1 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family GTP_EFTU PF00009.27 CDW57988.1 - 1.6e-21 76.7 0.0 2.6e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SelB-wing_3 PF09107.11 CDW57988.1 - 1.1e-19 69.8 0.4 2.3e-19 68.8 0.4 1.6 1 0 0 1 1 1 1 Elongation factor SelB, winged helix SelB-wing_2 PF09106.11 CDW57988.1 - 5e-15 55.4 1.3 5e-15 55.4 1.3 2.4 3 0 0 3 3 3 1 Elongation factor SelB, winged helix GTP_EFTU_D2 PF03144.25 CDW57988.1 - 1.3e-09 38.3 0.0 3.9e-09 36.8 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CDW57988.1 - 0.0012 18.8 0.0 0.0028 17.6 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase GTP_EFTU_D4 PF14578.6 CDW57988.1 - 0.0028 17.5 0.0 0.0067 16.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 HrcA PF01628.21 CDW57988.1 - 0.027 14.4 0.1 0.06 13.2 0.1 1.5 2 0 0 2 2 2 0 HrcA protein C terminal domain Fe-ADH PF00465.19 CDW57989.1 - 2.5e-121 404.9 8.8 2.8e-121 404.8 8.8 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CDW57989.1 - 1.7e-17 64.0 5.3 7.9e-10 38.9 0.0 2.2 1 1 1 2 2 2 2 Iron-containing alcohol dehydrogenase Lamprin PF06403.11 CDW57989.1 - 0.0021 18.0 1.0 0.0045 17.0 1.0 1.5 1 0 0 1 1 1 1 Lamprin Inositol_P PF00459.25 CDW57989.1 - 0.054 13.0 0.1 0.11 12.0 0.1 1.5 1 1 0 1 1 1 0 Inositol monophosphatase family Aldedh PF00171.22 CDW57990.1 - 6.8e-164 545.8 0.0 7.6e-164 545.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LysR_substrate PF03466.20 CDW57991.1 - 1.5e-17 63.7 0.0 2.7e-17 62.8 0.0 1.5 1 1 0 1 1 1 1 LysR substrate binding domain Arg_decarbox_C PF17944.1 CDW57991.1 - 0.022 15.3 0.8 0.05 14.2 0.8 1.5 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension MipA PF06629.12 CDW57992.1 - 9.5e-50 169.8 5.7 1.1e-49 169.6 5.7 1.0 1 0 0 1 1 1 1 MltA-interacting protein MipA Cu_bind_CorA PF18252.1 CDW57992.1 - 0.081 12.5 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Copper(I)-binding protein CorA FGGY_N PF00370.21 CDW57993.1 - 7.1e-76 255.0 0.0 1.2e-75 254.2 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Aldolase_II PF00596.21 CDW57993.1 - 2.3e-45 154.8 1.0 5.1e-45 153.7 1.0 1.7 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain AP_endonuc_2 PF01261.24 CDW57993.1 - 4.3e-36 124.3 0.1 3.2e-35 121.5 0.0 2.2 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel OMPdecase PF00215.24 CDW57993.1 - 1.2e-24 87.2 0.2 2e-24 86.5 0.2 1.4 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family FGGY_C PF02782.16 CDW57993.1 - 3.4e-20 72.6 0.2 1.8e-19 70.2 0.1 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain UxuA PF03786.13 CDW57993.1 - 0.038 12.8 0.0 0.19 10.5 0.0 2.1 3 0 0 3 3 3 0 D-mannonate dehydratase (UxuA) Glyco_hydro_114 PF03537.13 CDW57993.1 - 0.13 11.6 0.2 0.32 10.3 0.2 1.6 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 DctP PF03480.13 CDW57994.1 - 2.1e-87 293.1 0.0 2.3e-87 293.0 0.0 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein, family 7 Gal_Lectin PF02140.18 CDW57995.1 - 2.4e-07 31.1 7.1 3.9e-05 24.0 5.5 3.1 2 1 0 2 2 2 2 Galactose binding lectin domain NICE-3 PF07406.11 CDW57996.1 - 1.2e-23 84.1 0.5 1.9e-23 83.4 0.5 1.3 1 1 0 1 1 1 1 NICE-3 protein DUF4129 PF13559.6 CDW57996.1 - 0.0031 17.7 0.0 0.0057 16.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) SNase PF00565.17 CDW57997.1 - 3.2e-61 204.5 0.0 6.1e-16 58.8 0.0 5.3 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 CDW57997.1 - 2.4e-26 92.1 0.0 4.7e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 Tudor domain DUF3895 PF13034.6 CDW57997.1 - 0.003 17.5 0.0 0.98 9.5 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF3895) SMN PF06003.12 CDW57997.1 - 0.08 12.2 0.0 0.23 10.7 0.0 1.8 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) MTHFR PF02219.17 CDW57998.1 - 8.6e-92 307.5 0.0 1.4e-91 306.8 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase SCO1-SenC PF02630.14 CDW57999.1 - 5.5e-47 159.0 0.0 6.9e-47 158.7 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 CDW57999.1 - 7.1e-06 26.0 0.0 1.3e-05 25.1 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family YqgF PF14639.6 CDW57999.1 - 0.062 13.1 0.0 9.1 6.0 0.0 2.3 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 COesterase PF00135.28 CDW58000.1 - 2.6e-144 481.9 0.0 3e-144 481.7 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CDW58000.1 - 5e-09 36.3 0.0 1.3e-08 35.0 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CDW58000.1 - 0.036 13.5 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family zf-RanBP PF00641.18 CDW58001.1 - 0.36 10.2 7.9 0.13 11.6 4.6 1.9 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others MBT PF02820.18 CDW58003.1 - 1.3e-58 195.3 0.1 1.4e-17 63.8 0.0 4.5 4 0 0 4 4 4 4 mbt repeat Fip1 PF05182.13 CDW58004.1 - 3.5e-23 80.8 0.6 6.7e-23 79.9 0.6 1.5 1 0 0 1 1 1 1 Fip1 motif His_Phos_1 PF00300.22 CDW58005.1 - 3.6e-20 72.5 0.0 9.6e-19 67.8 0.0 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) p450 PF00067.22 CDW58006.1 - 3.2e-85 286.6 0.0 4.2e-85 286.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 AF-4 PF05110.13 CDW58007.1 - 1.4e-09 36.7 0.0 0.00012 20.4 0.0 2.1 1 1 1 2 2 2 2 AF-4 proto-oncoprotein AF-4 PF05110.13 CDW58008.1 - 5.6e-26 91.0 21.9 2.5e-16 59.0 6.5 2.8 1 1 2 3 3 3 3 AF-4 proto-oncoprotein PID PF00640.23 CDW58009.1 - 3.3e-37 127.6 0.0 5.5e-26 91.3 0.0 2.5 2 1 0 2 2 2 2 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 CDW58009.1 - 0.03 14.5 0.0 0.099 12.8 0.0 1.9 2 0 0 2 2 2 0 Phosphotyrosine-binding domain MIF4G PF02854.19 CDW58010.1 - 0.13 11.8 1.9 0.2 11.3 0.1 2.3 3 0 0 3 3 3 0 MIF4G domain TIM PF00121.18 CDW58011.1 - 6.5e-90 300.8 0.0 7.5e-90 300.5 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase ECH_1 PF00378.20 CDW58011.1 - 0.052 12.9 0.0 0.079 12.3 0.0 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase Phospholip_B PF04916.13 CDW58012.1 - 1.7e-155 518.6 4.1 2.1e-155 518.3 4.1 1.0 1 0 0 1 1 1 1 Phospholipase B Pkinase PF00069.25 CDW58013.1 - 1.6e-62 211.3 0.1 1.9e-62 211.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58013.1 - 6.3e-18 65.0 0.0 9e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW58013.1 - 5.4e-05 23.2 0.0 0.0097 15.8 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 CDW58013.1 - 0.0001 21.8 0.0 0.0043 16.4 0.0 2.1 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 CDW58013.1 - 0.0083 15.7 1.7 0.046 13.3 1.7 2.1 1 1 0 1 1 1 1 RIO1 family ABC1 PF03109.16 CDW58013.1 - 0.014 15.6 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 ABC1 family Kdo PF06293.14 CDW58013.1 - 0.027 13.8 0.4 0.05 13.0 0.4 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF5082 PF16888.5 CDW58014.1 - 0.034 14.4 1.8 1.8 8.9 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) CdvA PF18822.1 CDW58014.1 - 0.087 12.7 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 CdvA-like coiled-coil domain ATP-synt_D PF01813.17 CDW58014.1 - 0.19 11.6 0.3 0.31 10.9 0.3 1.3 1 0 0 1 1 1 0 ATP synthase subunit D Pkinase PF00069.25 CDW58015.1 - 1.2e-45 156.0 0.0 2.5e-45 154.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58015.1 - 1.3e-23 83.7 0.0 2e-22 79.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW58015.1 - 2.6e-07 29.8 0.0 3.8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CDW58015.1 - 2.4e-05 23.8 0.0 4e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDW58015.1 - 0.054 13.4 0.0 0.076 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-C2H2_2 PF12756.7 CDW58017.1 - 9.1e-29 99.8 11.9 1.1e-24 86.7 1.9 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) LRR_6 PF13516.6 CDW58017.1 - 0.008 16.2 0.3 0.14 12.3 0.1 2.6 2 0 0 2 2 2 1 Leucine Rich repeat LRR_4 PF12799.7 CDW58017.1 - 0.0097 16.3 0.0 3.1 8.4 0.0 2.8 2 1 0 2 2 2 1 Leucine Rich repeats (2 copies) zf-C2H2_jaz PF12171.8 CDW58017.1 - 0.011 16.0 4.3 0.011 16.0 4.3 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW58017.1 - 0.06 13.8 9.1 0.055 13.9 4.7 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CDW58017.1 - 0.32 11.0 7.0 0.41 10.7 4.5 2.5 3 0 0 3 3 3 0 C2H2-type zinc finger Complex1_49kDa PF00346.19 CDW58018.1 - 1.1e-120 401.8 0.0 1.1e-120 401.8 0.0 3.5 4 1 1 5 5 5 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit SMC_N PF02463.19 CDW58018.1 - 5.5e-56 189.4 41.7 4.8e-54 183.1 41.7 3.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDW58018.1 - 1.6e-22 80.0 0.0 6.6e-22 78.0 0.0 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CDW58018.1 - 9.1e-11 42.1 14.8 1.1e-06 28.7 1.0 4.5 3 2 2 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CDW58018.1 - 2.8e-08 34.5 24.5 2.8e-08 34.5 24.5 7.0 2 2 3 5 5 5 1 AAA domain DUF724 PF05266.14 CDW58018.1 - 0.0022 17.9 9.9 0.0022 17.9 9.9 7.6 2 2 6 8 8 8 2 Protein of unknown function (DUF724) AAA_29 PF13555.6 CDW58018.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Methyltransf_25 PF13649.6 CDW58018.1 - 0.11 13.2 0.3 50 4.7 0.0 3.5 3 0 0 3 3 3 0 Methyltransferase domain RraB PF06877.11 CDW58018.1 - 3.9 8.2 7.1 2 9.2 1.0 3.8 2 1 1 3 3 3 0 Regulator of ribonuclease activity B zf-RRN7 PF11781.8 CDW58019.1 - 0.0012 18.5 5.7 0.0026 17.4 5.7 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-RRPl_C4 PF17026.5 CDW58019.1 - 0.058 13.5 1.4 0.16 12.1 1.4 1.7 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type ANAPC16 PF17256.2 CDW58019.1 - 0.092 13.1 0.2 0.21 12.0 0.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 C1_2 PF03107.16 CDW58019.1 - 8.5 6.8 10.7 0.76 10.1 4.5 2.3 2 0 0 2 2 2 0 C1 domain AMP-binding PF00501.28 CDW58020.1 - 6.9e-58 196.2 0.0 1.1e-57 195.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW58020.1 - 1.9e-05 25.6 0.1 4.9e-05 24.2 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MAM33 PF02330.16 CDW58021.1 - 3.8e-31 108.7 0.4 4.8e-31 108.4 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein Jnk-SapK_ap_N PF09744.9 CDW58022.1 - 3.6e-52 176.7 20.8 3.6e-52 176.7 20.8 3.1 3 1 0 3 3 3 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.5 CDW58022.1 - 3.3e-28 97.7 9.9 3.3e-28 97.7 9.9 4.7 4 1 0 4 4 4 1 JNK-interacting protein leucine zipper II DUF1759 PF03564.15 CDW58022.1 - 0.3 11.0 6.6 0.025 14.5 1.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1759) ARL2_Bind_BART PF11527.8 CDW58022.1 - 1.6 8.9 6.7 1.7 8.8 0.2 3.1 3 1 1 4 4 4 0 The ARF-like 2 binding protein BART Herpes_UL6 PF01763.16 CDW58022.1 - 1.7 7.1 12.8 0.022 13.3 2.7 2.1 2 0 0 2 2 2 0 Herpesvirus UL6 like CSN8_PSD8_EIF3K PF10075.9 CDW58023.1 - 1.8e-20 73.4 0.0 6.4e-20 71.6 0.0 1.8 1 1 1 2 2 2 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 CDW58023.1 - 3.4e-09 36.5 0.2 5.2e-09 35.9 0.2 1.2 1 0 0 1 1 1 1 SAC3/GANP family DUF19 PF01579.18 CDW58024.1 - 0.00059 19.7 1.5 0.0079 16.0 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF19) RGM_N PF06535.12 CDW58024.1 - 0.032 14.4 2.5 2.7 8.1 0.1 2.3 2 0 0 2 2 2 0 Repulsive guidance molecule (RGM) N-terminus CPG4 PF15481.6 CDW58024.1 - 0.066 13.8 1.0 1.5 9.5 0.0 2.4 2 0 0 2 2 2 0 Chondroitin proteoglycan 4 Guanylate_cyc PF00211.20 CDW58025.1 - 3.8e-65 218.9 0.3 3.4e-64 215.9 0.1 2.5 2 1 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 CDW58025.1 - 1.2e-39 136.2 0.0 1.9e-39 135.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase ANF_receptor PF01094.28 CDW58025.1 - 5.2e-37 127.8 0.3 2.6e-22 79.4 0.1 2.4 2 0 0 2 2 2 2 Receptor family ligand binding region Pkinase PF00069.25 CDW58025.1 - 6.6e-34 117.5 0.0 1.9e-33 116.0 0.0 1.7 1 1 1 2 2 2 1 Protein kinase domain HNOBA PF07701.14 CDW58025.1 - 0.00052 19.5 0.7 0.001 18.5 0.7 1.5 1 0 0 1 1 1 1 Heme NO binding associated Forkhead PF00250.18 CDW58027.1 - 1.3e-35 121.5 0.1 2e-35 120.9 0.1 1.3 1 0 0 1 1 1 1 Forkhead domain NDUF_B7 PF05676.13 CDW58028.1 - 1.7e-22 78.9 10.7 2.2e-22 78.5 10.7 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 CDW58028.1 - 0.0067 16.4 6.8 0.012 15.7 6.7 1.5 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 CDW58028.1 - 0.16 12.0 1.4 0.25 11.4 1.4 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, RIO1 PF01163.22 CDW58029.1 - 6.3e-64 215.0 1.1 1.1e-63 214.3 0.0 1.9 2 0 0 2 2 2 1 RIO1 family Pkinase_fungal PF17667.1 CDW58029.1 - 0.014 14.2 4.0 0.018 13.8 0.0 2.5 2 1 0 2 2 2 0 Fungal protein kinase NUDIX PF00293.28 CDW58030.1 - 4e-10 39.9 0.0 5.5e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain MRP-L47 PF06984.13 CDW58031.1 - 1e-31 108.9 1.1 1.7e-31 108.2 1.1 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) AhpC-TSA PF00578.21 CDW58032.1 - 1.9e-37 128.0 0.0 2.6e-37 127.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDW58032.1 - 1e-15 57.7 0.0 1.3e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDW58032.1 - 1.5e-12 47.1 0.1 2.9e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Ank_5 PF13857.6 CDW58033.1 - 7.1e-23 80.4 6.6 1.1e-10 41.5 0.1 3.4 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW58033.1 - 9.8e-23 80.2 0.4 4e-10 40.0 0.1 3.5 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CDW58033.1 - 4.4e-22 77.5 3.9 1.1e-07 31.9 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 CDW58033.1 - 1e-21 77.3 0.1 3.9e-10 40.2 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW58033.1 - 9.6e-19 65.5 0.6 0.00014 22.0 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat dsrm PF00035.26 CDW58034.1 - 1.2e-27 96.3 0.2 3.3e-11 43.7 0.0 3.5 3 0 0 3 3 3 3 Double-stranded RNA binding motif DND1_DSRM PF14709.7 CDW58034.1 - 3.4e-15 56.1 2.6 5.1e-07 29.8 0.1 3.9 3 2 0 3 3 3 2 double strand RNA binding domain from DEAD END PROTEIN 1 Staufen_C PF16482.5 CDW58034.1 - 0.00017 21.7 0.0 0.014 15.6 0.0 3.3 4 1 1 5 5 5 1 Staufen C-terminal domain LPP20 PF02169.16 CDW58034.1 - 0.026 14.9 0.2 6.6 7.2 0.0 2.6 2 0 0 2 2 2 0 LPP20 lipoprotein LBP_BPI_CETP_C PF02886.17 CDW58035.1 - 2.9e-28 98.9 0.7 1.2e-27 96.9 0.1 2.2 3 0 0 3 3 3 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 CDW58035.1 - 4e-07 29.8 0.3 1.1e-06 28.3 0.0 1.8 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain RRM_1 PF00076.22 CDW58036.1 - 5.7e-32 109.4 0.2 2.2e-15 56.2 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW58036.1 - 8e-05 22.4 0.0 2.3 8.1 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 CDW58036.1 - 0.00011 22.2 0.0 0.035 14.2 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif Transformer PF06495.11 CDW58036.1 - 0.022 14.8 13.5 0.035 14.2 13.5 1.3 1 0 0 1 1 1 0 Fruit fly transformer protein TcpA PF05946.12 CDW58036.1 - 0.13 12.4 0.0 0.3 11.2 0.0 1.6 2 0 0 2 2 2 0 Toxin-coregulated pilus subunit TcpA RSRP PF17069.5 CDW58036.1 - 2.1 7.8 23.6 0.99 8.9 21.1 1.6 2 0 0 2 2 2 0 Arginine/Serine-Rich protein 1 CDK5_activator PF03261.15 CDW58037.1 - 3e-74 250.7 2.2 3.3e-74 250.6 1.3 1.4 1 1 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein Kunitz_BPTI PF00014.23 CDW58038.1 - 6e-71 234.5 64.7 1.4e-16 60.4 7.2 7.0 6 0 0 6 6 6 5 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 CDW58038.1 - 1.4e-43 147.0 199.6 7.4e-08 32.7 10.7 14.1 14 0 0 14 14 14 9 Lustrin, cysteine-rich repeated domain EB PF01683.18 CDW58038.1 - 4e-06 27.0 17.4 0.00014 22.0 3.0 12.4 8 5 1 9 9 9 2 EB module SP_C-Propep PF08999.10 CDW58038.1 - 0.21 11.4 0.1 0.76 9.6 0.1 1.9 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide MTS_N PF08468.11 CDW58039.1 - 1.2e-56 191.1 0.0 1.6e-56 190.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain N-terminal MTS PF05175.14 CDW58039.1 - 1.3e-33 115.9 0.0 2.1e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CDW58039.1 - 2e-09 38.0 0.4 9e-09 35.9 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW58039.1 - 1.4e-08 34.7 0.0 2.3e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDW58039.1 - 1.7e-08 34.2 0.0 2.3e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 CDW58039.1 - 6.1e-07 30.1 0.0 1.7e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain NodS PF05401.11 CDW58039.1 - 3.4e-05 23.5 0.0 0.00064 19.4 0.0 2.1 2 0 0 2 2 2 1 Nodulation protein S (NodS) Methyltransf_23 PF13489.6 CDW58039.1 - 3.8e-05 23.6 0.0 0.00017 21.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW58039.1 - 0.00074 20.1 0.0 0.0015 19.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW58039.1 - 0.001 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CDW58039.1 - 0.014 15.1 0.0 0.044 13.5 0.0 1.7 2 0 0 2 2 2 0 Lysine methyltransferase Methyltransf_2 PF00891.18 CDW58039.1 - 0.019 14.3 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain GidB PF02527.15 CDW58039.1 - 0.026 13.9 0.1 0.045 13.1 0.1 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G tRNA_U5-meth_tr PF05958.11 CDW58039.1 - 0.11 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_32 PF13679.6 CDW58039.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CDW58039.1 - 0.16 11.3 0.0 0.35 10.2 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family DNA_III_psi PF03603.13 CDW58040.1 - 2.6e-33 114.9 0.1 3.5e-33 114.5 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase III psi subunit Acetyltransf_1 PF00583.25 CDW58040.1 - 1.2e-17 64.2 0.0 1.6e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW58040.1 - 3.6e-14 52.8 0.0 8.4e-14 51.6 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW58040.1 - 2.4e-13 50.3 0.0 3.8e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW58040.1 - 2.9e-12 46.4 0.1 5e-12 45.6 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein GNAT_acetyltran PF12746.7 CDW58040.1 - 1.3e-08 34.7 0.0 1.8e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_4 PF13420.7 CDW58040.1 - 1e-06 29.0 0.0 1.4e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDW58040.1 - 2.1e-05 24.6 0.0 3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CSTF_C PF14304.6 CDW58040.1 - 9.5e-05 21.9 0.1 0.00025 20.6 0.1 1.7 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal Acetyltransf_6 PF13480.7 CDW58040.1 - 9.8e-05 22.5 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CDW58040.1 - 0.00056 19.6 0.0 0.00091 18.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDW58040.1 - 0.00059 20.5 0.0 0.00067 20.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CDW58040.1 - 0.0032 17.0 0.0 0.0067 15.9 0.0 1.5 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_CG PF14542.6 CDW58040.1 - 0.0062 16.6 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltr_2 PF13718.6 CDW58040.1 - 0.055 12.9 0.0 0.077 12.4 0.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FlgO PF17680.1 CDW58040.1 - 0.068 12.9 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 FlgO protein Nudix_hydro PF18290.1 CDW58040.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Nudix hydrolase domain HAD_2 PF13419.6 CDW58041.1 - 8.8e-21 74.8 0.0 1.1e-20 74.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW58041.1 - 6.5e-16 59.2 0.0 8e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW58041.1 - 3.3e-12 46.3 0.0 6.1e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like RF3_C PF16658.5 CDW58042.1 - 3.8e-47 159.4 0.1 6.9e-47 158.5 0.1 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU PF00009.27 CDW58042.1 - 1.7e-46 158.2 0.0 2.6e-46 157.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CDW58042.1 - 1.2e-11 44.8 0.1 4.1e-11 43.1 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW58042.1 - 0.00012 22.1 0.0 0.00025 21.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CDW58042.1 - 0.00015 21.8 0.0 0.00028 20.9 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 CDW58042.1 - 0.045 13.3 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Ras family Roc PF08477.13 CDW58042.1 - 0.15 12.3 0.0 0.48 10.6 0.0 1.9 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase BON PF04972.17 CDW58043.1 - 2.7e-34 117.3 15.3 2.9e-19 69.1 6.1 2.3 2 0 0 2 2 2 2 BON domain Patatin PF01734.22 CDW58043.1 - 3.3e-21 76.4 0.2 3.6e-20 73.0 0.2 2.2 1 1 0 1 1 1 1 Patatin-like phospholipase DUF1328 PF07043.13 CDW58043.1 - 1.7e-11 44.1 24.4 3.8e-11 43.0 22.6 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1328) DUF872 PF05915.12 CDW58043.1 - 0.17 12.0 0.3 0.47 10.6 0.3 1.8 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) HMA PF00403.26 CDW58043.1 - 1.3 9.5 4.6 1.2 9.6 1.9 2.4 1 1 1 2 2 2 0 Heavy-metal-associated domain DUF1676 PF07898.13 CDW58043.1 - 5.9 6.9 5.6 3.7 7.6 1.8 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF1676) DUF3029 PF11230.8 CDW58044.1 - 4.8e-221 734.3 0.0 6e-221 734.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3029) Radical_SAM PF04055.21 CDW58044.1 - 4.9e-24 85.6 0.4 9.1e-24 84.7 0.4 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDW58044.1 - 2.7e-09 37.4 3.9 1.2e-08 35.3 3.9 2.0 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4 PF00037.27 CDW58044.1 - 3.9e-07 29.6 9.3 8.4e-05 22.2 0.9 2.7 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDW58044.1 - 4.2e-05 23.6 13.9 4.2e-05 23.6 13.9 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDW58044.1 - 8e-05 23.5 9.5 0.028 15.3 1.6 2.7 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 CDW58044.1 - 0.00061 20.3 13.5 0.00061 20.3 13.5 2.0 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDW58044.1 - 0.00071 19.5 1.4 0.00071 19.5 1.4 2.9 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CDW58044.1 - 0.014 15.8 2.1 0.014 15.8 2.1 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_21 PF14697.6 CDW58044.1 - 0.023 14.8 11.4 0.068 13.3 11.4 1.8 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDW58044.1 - 0.065 13.8 17.5 1.1 9.9 1.2 2.7 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDW58044.1 - 0.18 11.9 22.2 0.027 14.6 15.3 2.7 1 1 2 3 3 3 0 4Fe-4S dicluster domain PRIMA1 PF16101.5 CDW58044.1 - 0.22 11.5 3.3 0.68 10.0 3.3 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NRDD PF13597.6 CDW58044.1 - 1.7 7.3 0.0 1.7 7.3 0.0 2.6 4 0 0 4 4 3 0 Anaerobic ribonucleoside-triphosphate reductase Glycos_transf_3 PF00591.21 CDW58045.1 - 1.8e-53 181.7 1.1 3e-53 181.0 1.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain PYNP_C PF07831.13 CDW58045.1 - 4.3e-26 90.4 0.2 8.5e-26 89.4 0.2 1.5 1 0 0 1 1 1 1 Pyrimidine nucleoside phosphorylase C-terminal domain Glycos_trans_3N PF02885.17 CDW58045.1 - 2.4e-19 68.9 0.1 9.6e-19 67.0 0.1 2.1 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Metalloenzyme PF01676.18 CDW58046.1 - 5e-39 134.2 0.0 7.5e-39 133.6 0.0 1.3 1 1 0 1 1 1 1 Metalloenzyme superfamily Bac_DNA_binding PF00216.21 CDW58046.1 - 0.11 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial DNA-binding protein Phosphodiest PF01663.22 CDW58046.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase PNP_UDP_1 PF01048.20 CDW58047.1 - 7.1e-40 136.7 1.4 8.4e-40 136.5 1.4 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Transketolase_C PF02780.20 CDW58047.1 - 0.047 13.6 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Transketolase, C-terminal domain BPL_LplA_LipB PF03099.19 CDW58048.1 - 6.9e-10 38.9 0.0 3.3e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family HTH_19 PF12844.7 CDW58048.1 - 0.032 14.2 0.1 0.53 10.4 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain Sigma70_r4 PF04545.16 CDW58048.1 - 0.066 12.7 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_3 PF01381.22 CDW58048.1 - 0.13 12.4 0.5 0.51 10.4 0.1 2.3 3 0 0 3 3 3 0 Helix-turn-helix DUF5609 PF18429.1 CDW58049.1 - 5.4e-25 86.9 0.1 1.1e-24 85.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5609) HAD PF12710.7 CDW58049.1 - 3e-18 66.9 0.1 8e-18 65.5 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ATPase PF06745.13 CDW58049.1 - 2.4e-17 63.0 0.1 7.9e-11 41.7 0.1 2.3 1 1 1 2 2 2 2 KaiC AAA_25 PF13481.6 CDW58049.1 - 5.7e-15 55.4 0.0 1.5e-14 54.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain Hydrolase PF00702.26 CDW58049.1 - 6.2e-14 52.8 0.7 1.5e-13 51.6 0.7 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDW58049.1 - 2.4e-12 47.2 0.0 3.2e-11 43.5 0.0 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase ChlI PF13541.6 CDW58049.1 - 6.6e-10 38.9 0.1 3.3e-09 36.6 0.0 2.2 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase DnaB_C PF03796.15 CDW58049.1 - 1.2e-07 31.4 0.3 0.00017 21.1 0.0 2.3 1 1 1 2 2 2 2 DnaB-like helicase C terminal domain Lon_C PF05362.13 CDW58049.1 - 1.9e-07 30.8 0.1 4.9e-07 29.5 0.1 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain Rad51 PF08423.11 CDW58049.1 - 8.4e-07 28.5 0.8 0.00019 20.8 0.5 2.7 2 1 0 2 2 2 1 Rad51 RecA PF00154.21 CDW58049.1 - 7.9e-06 25.5 0.6 6.1e-05 22.6 0.1 2.2 2 0 0 2 2 2 1 recA bacterial DNA recombination protein Rubredoxin_2 PF18073.1 CDW58049.1 - 0.00054 19.6 0.3 0.00097 18.8 0.3 1.4 1 0 0 1 1 1 1 Rubredoxin metal binding domain AAA_14 PF13173.6 CDW58049.1 - 0.0011 19.1 0.0 0.0082 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain Put_Phosphatase PF06888.12 CDW58049.1 - 0.0015 18.0 0.0 0.01 15.2 0.0 2.0 2 0 0 2 2 2 1 Putative Phosphatase GvpD PF07088.11 CDW58049.1 - 0.0022 16.7 0.1 0.062 11.9 0.0 2.2 1 1 1 2 2 2 1 GvpD gas vesicle protein DUF2075 PF09848.9 CDW58049.1 - 0.0028 16.9 0.0 0.0045 16.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 CDW58049.1 - 0.0031 17.9 0.0 0.009 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 CDW58049.1 - 0.004 17.7 0.0 0.0082 16.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_24 PF13479.6 CDW58049.1 - 0.005 16.6 0.0 0.0087 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW58049.1 - 0.0064 16.8 0.1 0.016 15.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CDW58049.1 - 0.013 15.9 0.3 0.055 13.9 0.1 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) S6PP PF05116.13 CDW58049.1 - 0.013 15.0 0.0 0.04 13.5 0.0 1.8 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase Zeta_toxin PF06414.12 CDW58049.1 - 0.014 14.7 0.1 0.029 13.6 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin T2SSE PF00437.20 CDW58049.1 - 0.017 14.2 0.1 0.047 12.7 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein cobW PF02492.19 CDW58049.1 - 0.019 14.5 0.0 0.048 13.2 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 CDW58049.1 - 0.053 13.4 1.6 0.21 11.5 0.1 2.6 2 1 1 3 3 3 0 NTPase AAA_29 PF13555.6 CDW58049.1 - 0.12 12.1 0.4 0.27 11.0 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 CDW58049.1 - 0.15 12.1 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Herpes_Helicase PF02689.14 CDW58049.1 - 0.23 9.3 0.0 0.34 8.8 0.0 1.1 1 0 0 1 1 1 0 Helicase ABC_tran PF00005.27 CDW58050.1 - 2.1e-60 203.2 0.2 1.4e-32 113.1 0.0 2.9 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 CDW58050.1 - 8e-17 62.0 1.8 0.00015 21.7 0.0 4.3 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 CDW58050.1 - 4.9e-13 48.9 8.1 1.3e-11 44.3 3.2 2.4 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 CDW58050.1 - 2.9e-07 30.1 1.1 0.25 10.8 0.1 4.1 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CDW58050.1 - 6.7e-06 26.2 0.1 0.053 13.6 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 CDW58050.1 - 9.9e-06 26.2 6.8 0.002 18.7 0.1 3.3 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 CDW58050.1 - 1.3e-05 24.8 0.8 0.021 14.5 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CDW58050.1 - 0.00012 22.4 0.1 0.082 13.2 0.0 3.0 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDW58050.1 - 0.00021 21.2 0.2 0.056 13.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CDW58050.1 - 0.00035 21.0 7.4 1.4 9.3 4.3 3.6 2 1 1 3 3 3 2 AAA ATPase domain SbcCD_C PF13558.6 CDW58050.1 - 0.0014 18.8 1.1 1.8 8.9 0.0 4.0 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 CDW58050.1 - 0.0022 18.6 1.7 2.9 8.4 0.1 3.4 3 1 0 3 3 2 2 AAA domain AAA_27 PF13514.6 CDW58050.1 - 0.0024 17.5 0.0 0.48 10.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CDW58050.1 - 0.0027 17.9 0.0 2.1 8.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 CDW58050.1 - 0.0048 15.9 0.2 1.7 7.6 0.1 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP-synt_ab PF00006.25 CDW58050.1 - 0.011 15.5 0.1 0.082 12.6 0.0 2.0 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Roc PF08477.13 CDW58050.1 - 0.014 15.6 0.7 1.2 9.3 0.0 2.8 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CDW58050.1 - 0.02 14.6 0.1 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 CDW58050.1 - 0.02 13.6 4.8 1 7.9 0.0 2.8 3 1 0 3 3 2 0 AAA domain AAA_28 PF13521.6 CDW58050.1 - 0.022 15.0 3.0 0.71 10.1 0.0 3.2 3 1 0 3 3 2 0 AAA domain Arf PF00025.21 CDW58050.1 - 0.024 14.1 0.1 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_15 PF13175.6 CDW58050.1 - 0.028 14.1 0.5 2.6 7.7 0.1 3.3 3 1 0 4 4 4 0 AAA ATPase domain cobW PF02492.19 CDW58050.1 - 0.037 13.6 0.4 3.1 7.4 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain HAUS4 PF14735.6 CDW58050.1 - 0.041 13.6 0.1 0.085 12.6 0.1 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 NB-ARC PF00931.22 CDW58050.1 - 0.049 12.8 2.0 0.81 8.8 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain AAA_30 PF13604.6 CDW58050.1 - 0.051 13.3 0.3 5.6 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain DLIC PF05783.11 CDW58050.1 - 0.075 11.8 0.1 4.5 6.0 0.0 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) AAA_14 PF13173.6 CDW58050.1 - 0.079 13.0 0.0 5.8 7.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 CDW58050.1 - 0.12 11.9 2.0 9.5 5.7 0.0 3.9 5 0 0 5 5 5 0 AAA domain Dynamin_N PF00350.23 CDW58050.1 - 0.13 12.4 3.9 0.56 10.2 0.0 2.8 3 1 0 3 3 2 0 Dynamin family ABC_ATPase PF09818.9 CDW58050.1 - 0.29 9.9 0.8 3.3 6.4 0.1 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class MRP-L46 PF11788.8 CDW58050.1 - 1.2 9.9 5.0 0.28 11.9 1.2 1.8 2 0 0 2 2 1 0 39S mitochondrial ribosomal protein L46 Jnk-SapK_ap_N PF09744.9 CDW58050.1 - 1.9 8.7 11.8 4.1 7.6 0.1 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 SLT PF01464.20 CDW58051.1 - 2.4e-34 117.5 0.0 4.6e-34 116.6 0.0 1.5 1 0 0 1 1 1 1 Transglycosylase SLT domain SLT_L PF14718.6 CDW58051.1 - 5.1e-23 81.0 5.5 5.1e-23 81.0 5.5 3.6 2 1 0 2 2 2 1 Soluble lytic murein transglycosylase L domain Cucumo_coat PF00760.18 CDW58051.1 - 0.00016 21.4 0.0 0.00064 19.4 0.0 2.0 1 1 1 2 2 2 1 Cucumovirus coat protein TPR_19 PF14559.6 CDW58051.1 - 0.025 15.1 0.3 0.025 15.1 0.3 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat NTPase_I-T PF01931.18 CDW58052.1 - 4.3e-37 127.4 0.0 5.3e-37 127.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 His_Phos_1 PF00300.22 CDW58053.1 - 5.1e-44 150.3 0.7 6e-44 150.1 0.7 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) PTH2 PF01981.16 CDW58053.1 - 0.039 14.2 0.2 0.12 12.7 0.1 1.7 1 1 1 2 2 2 0 Peptidyl-tRNA hydrolase PTH2 HOK_GEF PF01848.16 CDW58053.1 - 0.049 13.1 0.5 0.093 12.2 0.5 1.4 1 0 0 1 1 1 0 Hok/gef family GyrI-like PF06445.15 CDW58054.1 - 6.8e-22 78.4 0.0 8.8e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 GyrI-like small molecule binding domain HTH_18 PF12833.7 CDW58054.1 - 1.4e-19 70.1 2.4 2.2e-19 69.5 2.4 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CDW58054.1 - 1.1e-13 50.9 0.1 4.3e-07 29.9 0.2 2.5 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Cass2 PF14526.6 CDW58054.1 - 3.2e-07 30.6 0.0 5.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Integron-associated effector binding protein CreA PF05981.12 CDW58055.1 - 1.1e-48 164.5 0.1 1.9e-48 163.7 0.1 1.3 1 0 0 1 1 1 1 CreA protein Response_reg PF00072.24 CDW58055.1 - 3.4e-25 88.4 0.0 9.6e-25 86.9 0.0 1.9 1 0 0 1 1 1 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDW58055.1 - 4.2e-23 81.2 0.1 1.7e-22 79.2 0.0 2.1 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal HATPase_c PF02518.26 CDW58055.1 - 2e-17 63.7 0.0 4.8e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDW58055.1 - 2e-12 47.0 0.2 4.8e-12 45.7 0.2 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDW58055.1 - 2.2e-09 37.6 0.8 2.4e-06 27.8 0.0 3.0 3 0 0 3 3 3 2 HAMP domain sCache_3_2 PF17203.4 CDW58055.1 - 7.3e-06 26.2 0.0 2.2e-05 24.6 0.0 1.8 1 0 0 1 1 1 1 Single cache domain 3 HATPase_c_5 PF14501.6 CDW58055.1 - 0.00092 19.1 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 GHKL domain dCache_1 PF02743.18 CDW58055.1 - 0.0092 15.8 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 Cache domain HATPase_c_3 PF13589.6 CDW58055.1 - 0.013 15.3 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CDW58055.1 - 0.045 13.7 0.0 0.2 11.7 0.0 2.1 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain GAF PF01590.26 CDW58055.1 - 0.046 14.4 0.0 0.16 12.6 0.0 1.9 2 0 0 2 2 1 0 GAF domain GAF_2 PF13185.6 CDW58055.1 - 0.11 12.9 0.0 0.33 11.3 0.0 1.9 1 0 0 1 1 1 0 GAF domain CreD PF06123.12 CDW58056.1 - 2e-143 478.3 0.0 2.2e-143 478.1 0.0 1.0 1 0 0 1 1 1 1 Inner membrane protein CreD 7TMR-DISM_7TM PF07695.11 CDW58056.1 - 0.014 15.3 16.8 0.029 14.3 16.8 1.5 1 1 0 1 1 1 0 7TM diverse intracellular signalling Deltameth_res PF16020.5 CDW58056.1 - 0.036 13.9 0.1 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 Deltamethrin resistance INSIG PF07281.12 CDW58056.1 - 0.51 10.0 6.6 0.99 9.0 6.6 1.6 1 1 0 1 1 1 0 Insulin-induced protein (INSIG) Response_reg PF00072.24 CDW58057.1 - 2.7e-27 95.2 0.3 9.1e-27 93.5 0.1 1.8 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDW58057.1 - 1.4e-18 66.8 0.0 2.7e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal SpoU_methylase PF00588.19 CDW58058.1 - 2.3e-33 115.3 0.0 3.3e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 SpoU rRNA Methylase family OAM_dimer PF16554.5 CDW58058.1 - 0.054 13.9 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain of d-ornithine 4,5-aminomutase Homoserine_dh PF00742.19 CDW58059.1 - 6e-49 166.3 0.0 2.9e-48 164.1 0.0 2.1 2 0 0 2 2 2 1 Homoserine dehydrogenase AA_kinase PF00696.28 CDW58059.1 - 1.9e-46 158.6 0.3 5.8e-46 157.0 0.1 1.9 2 0 0 2 2 2 1 Amino acid kinase family NAD_binding_3 PF03447.16 CDW58059.1 - 8e-33 113.6 0.0 2.3e-32 112.1 0.0 1.9 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ACT_7 PF13840.6 CDW58059.1 - 3.5e-19 68.3 1.3 5.8e-09 35.6 0.3 2.7 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CDW58059.1 - 1.7e-17 62.9 0.3 7.8e-08 32.0 0.0 2.8 2 0 0 2 2 2 2 ACT domain GHMP_kinases_N PF00288.26 CDW58060.1 - 3.5e-14 52.8 0.3 7.6e-14 51.7 0.3 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CDW58060.1 - 6.5e-11 42.4 0.6 2.9e-10 40.4 0.0 2.3 3 0 0 3 3 3 1 GHMP kinases C terminal PALP PF00291.25 CDW58061.1 - 2.7e-24 86.1 0.0 3.8e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_synth_N PF14821.6 CDW58061.1 - 0.1 12.8 0.1 0.52 10.6 0.0 2.3 2 1 1 3 3 3 0 Threonine synthase N terminus H2O2_YaaD PF03883.14 CDW58062.1 - 4.5e-88 294.7 0.0 5.5e-88 294.4 0.0 1.0 1 0 0 1 1 1 1 Peroxide stress protein YaaA Na_Ala_symp PF01235.17 CDW58063.1 - 1.8e-142 475.3 25.6 2.1e-142 475.1 25.6 1.0 1 0 0 1 1 1 1 Sodium:alanine symporter family EMP70 PF02990.16 CDW58063.1 - 0.0015 17.3 2.5 0.0015 17.3 2.5 2.2 2 1 1 3 3 3 1 Endomembrane protein 70 TAL_FSA PF00923.19 CDW58064.1 - 4.5e-103 344.6 0.3 5e-103 344.4 0.3 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase MoCF_biosynth PF00994.24 CDW58065.1 - 5.2e-28 97.5 0.0 6.4e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Probable molybdopterin binding domain Gpr1_Fun34_YaaH PF01184.19 CDW58066.1 - 3.2e-41 141.2 21.8 3.6e-41 141.1 21.8 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Ubiq_cyt_C_chap PF03981.12 CDW58067.1 - 2.6e-23 82.7 0.2 4e-23 82.1 0.2 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone DUF3944 PF13099.6 CDW58067.1 - 1.3e-15 57.0 0.7 4e-15 55.4 0.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3944) Sdh5 PF03937.16 CDW58067.1 - 0.017 15.1 1.3 3.4 7.7 0.4 2.5 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase FERM_M PF00373.18 CDW58067.1 - 0.16 12.3 2.5 0.94 9.9 2.5 2.3 1 1 0 1 1 1 0 FERM central domain DUF1289 PF06945.13 CDW58067.1 - 0.19 11.5 0.4 0.45 10.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) DUF2541 PF10807.8 CDW58068.1 - 6.8e-62 207.3 0.4 7.4e-62 207.2 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2541) Thioredoxin PF00085.20 CDW58069.1 - 4.4e-18 65.2 0.1 6e-18 64.7 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 CDW58069.1 - 0.00077 19.6 0.0 0.0014 18.7 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CDW58069.1 - 0.0021 17.9 0.0 0.0022 17.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 CDW58069.1 - 0.0084 16.4 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CDW58069.1 - 0.015 15.1 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Redoxin Thioredoxin_2 PF13098.6 CDW58069.1 - 0.029 14.8 0.0 0.039 14.4 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Alpha_kinase PF02816.18 CDW58070.1 - 8.4e-62 208.6 0.4 1.7e-61 207.5 0.4 1.6 1 0 0 1 1 1 1 Alpha-kinase family Sel1 PF08238.12 CDW58070.1 - 4.6e-08 33.5 7.5 0.18 12.6 0.1 4.5 4 0 0 4 4 4 3 Sel1 repeat TPR_2 PF07719.17 CDW58070.1 - 0.13 12.4 1.7 8 6.8 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat fn3 PF00041.21 CDW58071.1 - 0.093 13.1 0.1 2.4 8.6 0.0 3.0 2 0 0 2 2 2 0 Fibronectin type III domain RRM_1 PF00076.22 CDW58072.1 - 6.8e-32 109.1 0.1 5.4e-18 64.6 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW58072.1 - 3.8e-12 46.1 0.5 6e-05 23.1 0.1 2.6 1 1 1 2 2 2 2 RNA recognition motif RL PF17797.1 CDW58072.1 - 0.00089 19.2 0.0 2.1 8.3 0.0 2.7 3 0 0 3 3 3 2 RL domain DUF1866 PF08952.11 CDW58072.1 - 0.0012 18.7 0.0 0.098 12.5 0.0 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF1866) RRM_occluded PF16842.5 CDW58072.1 - 0.0014 18.5 0.0 6.1 6.8 0.0 3.5 3 1 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CDW58072.1 - 0.0018 18.3 0.0 0.2 11.7 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 CDW58072.1 - 0.0053 16.6 0.0 1.7 8.4 0.0 2.3 2 0 0 2 2 2 2 Rrp7 RRM-like N-terminal domain PHM7_cyt PF14703.6 CDW58072.1 - 0.092 13.0 0.0 8.5 6.6 0.0 2.3 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter AMOP PF03782.17 CDW58073.1 - 6.8e-43 146.2 10.6 1.3e-42 145.3 10.6 1.5 1 0 0 1 1 1 1 AMOP domain VWD PF00094.25 CDW58073.1 - 1.7e-05 25.2 0.1 0.00038 20.7 0.2 2.9 1 1 1 2 2 2 1 von Willebrand factor type D domain NIDO PF06119.14 CDW58073.1 - 0.00012 22.9 0.0 0.00034 21.5 0.0 1.9 1 0 0 1 1 1 1 Nidogen-like Sushi PF00084.20 CDW58073.1 - 0.018 15.7 0.8 0.11 13.1 0.8 2.5 1 0 0 1 1 1 0 Sushi repeat (SCR repeat) KH_1 PF00013.29 CDW58074.1 - 1.2e-35 121.1 4.8 1.6e-12 47.1 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CDW58074.1 - 9.8e-12 44.5 1.4 3.1e-05 23.7 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CDW58074.1 - 9.5e-08 31.8 3.2 0.019 14.8 0.0 3.9 4 0 0 4 4 4 3 KH domain KH_5 PF13184.6 CDW58074.1 - 0.0043 17.1 2.6 2.3 8.4 0.2 3.6 3 0 0 3 3 3 1 NusA-like KH domain MOEP19 PF16005.5 CDW58074.1 - 0.0065 16.4 0.1 1.1 9.3 0.1 2.9 3 0 0 3 3 3 1 KH-like RNA-binding domain Cyclin PF08613.11 CDW58075.1 - 2.2e-08 34.7 0.0 3.4e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CDW58075.1 - 0.0073 16.0 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain eIF-5_eIF-2B PF01873.17 CDW58076.1 - 1.2e-41 141.2 0.3 2.6e-41 140.2 0.3 1.5 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 CDW58076.1 - 1.3e-22 79.7 1.1 2.8e-22 78.6 1.1 1.6 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon ERG2_Sigma1R PF04622.12 CDW58078.1 - 3.3e-22 78.9 0.0 4.3e-22 78.5 0.0 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein PDZ PF00595.24 CDW58079.1 - 1.2e-36 124.9 2.1 6.9e-13 48.8 0.3 3.4 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 CDW58079.1 - 3.3e-22 78.1 2.1 2.3e-07 30.5 0.0 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 CDW58079.1 - 1.8e-11 44.1 0.1 2.9e-11 43.4 0.1 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ_2 PF13180.6 CDW58079.1 - 7.8e-11 42.2 2.9 0.00041 20.6 0.2 3.5 3 0 0 3 3 3 3 PDZ domain ZU5 PF00791.20 CDW58079.1 - 1.1e-09 38.6 0.0 7.2e-09 35.9 0.0 2.3 1 1 0 1 1 1 1 ZU5 domain SH3_2 PF07653.17 CDW58079.1 - 1.1e-05 25.0 0.0 2.9e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW58079.1 - 0.0086 15.7 0.2 0.027 14.1 0.0 1.9 2 0 0 2 2 2 1 SH3 domain Telomere_reg-2 PF10193.9 CDW58080.1 - 0.055 13.9 0.0 65 4.0 0.0 3.1 1 1 2 3 3 3 0 Telomere length regulation protein DUF1213 PF06740.12 CDW58080.1 - 0.076 13.6 0.2 1.1e+02 3.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1213) Phage_Treg PF04761.12 CDW58080.1 - 0.1 12.7 0.1 38 4.5 0.0 3.6 4 0 0 4 4 4 0 Lactococcus bacteriophage putative transcription regulator RESP18 PF14948.6 CDW58080.1 - 0.13 12.6 0.1 19 5.6 0.0 3.1 1 1 3 4 4 4 0 RESP18 domain Rad4 PF03835.15 CDW58080.1 - 0.43 10.3 5.9 6.1 6.5 1.4 2.7 1 1 2 3 3 3 0 Rad4 transglutaminase-like domain DinB_2 PF12867.7 CDW58080.1 - 0.71 10.4 5.5 1.2e+02 3.1 5.5 3.5 1 1 0 1 1 1 0 DinB superfamily AAA PF00004.29 CDW58081.1 - 1.3e-41 142.1 0.0 2.4e-41 141.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDW58081.1 - 2.7e-25 88.1 0.1 8.9e-25 86.5 0.1 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 CDW58081.1 - 3.6e-24 84.6 6.4 9.9e-24 83.2 6.4 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 CDW58081.1 - 4.3e-08 32.8 0.0 2e-07 30.7 0.0 2.1 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 CDW58081.1 - 5.1e-06 26.3 0.0 1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CDW58081.1 - 1.9e-05 25.1 0.1 0.0089 16.4 0.0 3.1 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CDW58081.1 - 2.2e-05 24.5 0.0 5.9e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CDW58081.1 - 3.3e-05 23.7 0.0 6.4e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDW58081.1 - 8.8e-05 22.8 0.2 0.015 15.5 0.0 2.6 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 CDW58081.1 - 0.00033 20.0 0.0 0.00055 19.3 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 CDW58081.1 - 0.00042 20.9 0.1 0.0018 18.8 0.0 2.0 2 1 0 2 2 1 1 AAA domain AAA_14 PF13173.6 CDW58081.1 - 0.00052 20.0 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CDW58081.1 - 0.00072 19.7 0.1 0.002 18.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDW58081.1 - 0.0037 17.4 0.0 0.0078 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDW58081.1 - 0.0048 16.1 0.0 0.0098 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 CDW58081.1 - 0.009 15.6 0.3 0.32 10.6 0.2 2.3 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 CDW58081.1 - 0.015 14.9 0.0 0.034 13.7 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 CDW58081.1 - 0.016 15.0 0.0 0.041 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDW58081.1 - 0.019 15.3 0.0 0.055 13.9 0.0 1.9 1 0 0 1 1 1 0 RNA helicase PhoH PF02562.16 CDW58081.1 - 0.029 13.8 0.1 0.092 12.2 0.0 1.9 2 1 0 2 2 2 0 PhoH-like protein TniB PF05621.11 CDW58081.1 - 0.03 13.7 0.0 4.7 6.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein ATPase PF06745.13 CDW58081.1 - 0.038 13.3 0.3 3.5 6.9 0.1 2.5 1 1 1 2 2 2 0 KaiC NACHT PF05729.12 CDW58081.1 - 0.041 13.8 0.0 0.48 10.3 0.0 2.2 1 1 0 1 1 1 0 NACHT domain Parvo_NS1 PF01057.17 CDW58081.1 - 0.041 13.0 0.0 0.066 12.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Mg_chelatase PF01078.21 CDW58081.1 - 0.042 13.2 0.0 0.096 12.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDW58081.1 - 0.047 13.4 0.0 0.17 11.6 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain Tae4 PF14113.6 CDW58081.1 - 0.13 12.5 0.1 0.28 11.4 0.1 1.5 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 AAA_29 PF13555.6 CDW58081.1 - 0.13 12.0 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AFG1_ATPase PF03969.16 CDW58081.1 - 0.14 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 AFG1-like ATPase AAA_30 PF13604.6 CDW58081.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TPR_1 PF00515.28 CDW58081.1 - 0.17 11.7 0.3 0.67 9.9 0.3 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 CDW58081.1 - 0.56 10.4 5.4 0.25 11.5 1.2 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat 7tm_1 PF00001.21 CDW58082.1 - 2.5e-06 27.0 14.4 4.2e-06 26.3 14.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Mak10 PF04112.13 CDW58083.1 - 1.2e-06 28.1 0.0 1.4e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase AAA_2 PF07724.14 CDW58084.1 - 6.2e-33 114.3 0.0 9.3e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CDW58084.1 - 2.3e-12 47.5 0.0 4.6e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CDW58084.1 - 3.3e-09 36.7 0.1 1e-08 35.1 0.1 1.8 1 1 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Sigma54_activat PF00158.26 CDW58084.1 - 2.4e-05 24.1 0.1 0.0018 18.0 0.1 2.6 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 CDW58084.1 - 0.00021 20.7 0.2 0.022 14.1 0.1 2.8 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 CDW58084.1 - 0.00025 20.8 0.0 0.00069 19.4 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDW58084.1 - 0.00069 19.6 0.2 0.0031 17.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF4436 PF14494.6 CDW58084.1 - 0.0016 17.8 0.0 0.0026 17.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4436) AAA_22 PF13401.6 CDW58084.1 - 0.0025 18.1 0.1 0.0075 16.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CDW58084.1 - 0.0042 16.8 0.0 0.0076 16.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein T2SSE PF00437.20 CDW58084.1 - 0.0066 15.5 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein TsaE PF02367.17 CDW58084.1 - 0.024 14.7 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CDW58084.1 - 0.024 14.5 0.1 0.069 13.1 0.0 1.8 2 0 0 2 2 1 0 NACHT domain AAA_16 PF13191.6 CDW58084.1 - 0.027 14.9 0.0 0.059 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activ_2 PF14532.6 CDW58084.1 - 0.03 14.5 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DEAD PF00270.29 CDW58084.1 - 0.03 14.1 0.0 0.083 12.7 0.0 1.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_7 PF12775.7 CDW58084.1 - 0.04 13.4 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 CDW58084.1 - 0.096 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain PhoH PF02562.16 CDW58084.1 - 0.1 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.15 CDW58084.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 CDW58084.1 - 0.12 12.2 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CDW58084.1 - 0.12 12.6 0.0 0.87 9.7 0.0 2.3 3 0 0 3 3 2 0 AAA domain zinc_ribbon_4 PF13717.6 CDW58084.1 - 0.16 11.9 2.1 8 6.5 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain AAA_14 PF13173.6 CDW58084.1 - 0.16 12.0 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Collagen PF01391.18 CDW58085.1 - 5.4e-25 86.9 81.0 1.1e-08 34.7 20.9 4.2 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Trypsin PF00089.26 CDW58086.1 - 6.4e-62 209.3 0.1 7.7e-62 209.0 0.1 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW58086.1 - 1.6e-08 35.6 0.0 2.9e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW58086.1 - 0.073 13.5 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) Integrase_H2C2 PF17921.1 CDW58087.1 - 6.5e-11 42.2 0.3 1.7e-10 40.8 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain DUF5641 PF18701.1 CDW58087.1 - 0.0018 18.4 1.1 0.0018 18.4 1.1 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5641) Mito_carr PF00153.27 CDW58088.1 - 3.1e-62 206.5 5.1 6.3e-23 80.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CDW58088.1 - 0.015 14.4 2.4 0.077 12.1 0.0 3.0 2 2 2 4 4 4 0 Gammaproteobacterial serine protease LRR_8 PF13855.6 CDW58089.1 - 1.8e-151 492.0 202.2 6.8e-16 57.8 3.1 20.8 7 6 18 25 25 25 24 Leucine rich repeat LRR_4 PF12799.7 CDW58089.1 - 3.3e-73 240.3 138.5 6.7e-07 29.5 2.0 22.9 15 5 9 25 25 25 22 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 CDW58089.1 - 1.5e-42 144.6 16.1 5e-07 29.7 0.3 9.1 2 2 7 9 9 9 7 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 CDW58089.1 - 2.2e-22 79.4 65.8 0.0052 16.3 0.8 12.4 2 1 8 13 13 13 9 Leucine-rich repeat LRR_1 PF00560.33 CDW58089.1 - 1.1e-18 64.9 116.3 0.51 11.1 0.4 31.8 36 1 0 36 36 36 7 Leucine Rich Repeat LRR_6 PF13516.6 CDW58089.1 - 0.00047 20.0 121.7 0.064 13.3 0.1 28.8 33 0 0 33 33 33 5 Leucine Rich repeat Nbas_N PF15492.6 CDW58090.1 - 1.7e-09 37.5 0.1 7.1e-09 35.4 0.1 1.9 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal ASC PF00858.24 CDW58091.1 - 2.9e-57 194.6 6.1 3.4e-57 194.4 6.1 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Yip1 PF04893.17 CDW58092.1 - 2.4e-09 37.1 20.5 3.9e-09 36.4 18.9 1.8 1 1 0 1 1 1 1 Yip1 domain Herpes_IE1 PF07340.11 CDW58092.1 - 0.25 10.2 0.4 0.34 9.8 0.4 1.1 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein Arteri_Gl PF00951.18 CDW58093.1 - 0.047 13.5 1.0 0.047 13.5 1.0 2.1 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein Acetate_kinase PF00871.17 CDW58093.1 - 0.079 11.6 0.1 0.098 11.3 0.1 1.1 1 0 0 1 1 1 0 Acetokinase family DENN PF02141.21 CDW58094.1 - 1.7e-28 99.9 4.2 9.4e-28 97.4 4.2 2.2 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 CDW58094.1 - 3e-14 53.5 0.4 5.9e-14 52.6 0.4 1.5 1 0 0 1 1 1 1 uDENN domain SBF2 PF12335.8 CDW58094.1 - 0.006 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Myotubularin protein Pkinase PF00069.25 CDW58095.1 - 3.3e-73 246.3 0.0 4.4e-73 245.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58095.1 - 7.4e-40 136.9 0.0 1.1e-39 136.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW58095.1 - 8.2e-05 21.7 0.1 0.00014 21.0 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CDW58095.1 - 0.00013 21.4 0.0 0.00023 20.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDW58095.1 - 0.0021 18.0 0.1 0.01 15.8 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW58095.1 - 0.0058 16.0 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CDW58095.1 - 0.0078 15.8 0.1 0.014 15.0 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase PGM_PMM_I PF02878.16 CDW58097.1 - 4.4e-14 52.4 0.0 5.3e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I FHA PF00498.26 CDW58100.1 - 2.2e-15 56.7 0.0 6.3e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CDW58100.1 - 9.3e-05 22.7 0.0 0.00021 21.5 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MRP-S22 PF10245.9 CDW58101.1 - 5.5e-67 226.0 0.0 6.3e-67 225.9 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S22 MOLO1 PF17175.4 CDW58102.1 - 4.2e-05 23.6 1.3 0.00049 20.2 1.3 2.2 1 1 0 1 1 1 1 Modulator of levamisole receptor-1 BOP1NT PF08145.12 CDW58104.1 - 4.9e-95 318.4 9.6 8.5e-95 317.6 9.6 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 CDW58104.1 - 3.5e-26 90.9 0.3 2.3e-08 34.5 0.0 7.0 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW58104.1 - 1.5e-06 28.4 0.3 0.0079 16.5 0.0 4.2 2 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 CDW58104.1 - 0.0075 15.4 0.1 0.12 11.4 0.1 2.3 1 1 1 3 3 3 1 Coatomer WD associated region Nup160 PF11715.8 CDW58104.1 - 0.065 11.9 0.0 0.098 11.3 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PFOR_II PF17147.4 CDW58104.1 - 0.15 12.4 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II IKI3 PF04762.12 CDW58104.1 - 0.19 9.7 0.0 0.28 9.1 0.0 1.2 1 0 0 1 1 1 0 IKI3 family EGF PF00008.27 CDW58106.1 - 5.1e-05 23.5 41.7 0.0027 18.0 6.1 4.4 4 0 0 4 4 4 3 EGF-like domain EGF_3 PF12947.7 CDW58106.1 - 0.0048 17.1 2.2 0.0048 17.1 2.2 4.6 4 1 0 4 4 4 2 EGF domain hEGF PF12661.7 CDW58106.1 - 0.0093 16.6 34.3 0.05 14.3 7.6 4.8 4 0 0 4 4 4 2 Human growth factor-like EGF EGF_CA PF07645.15 CDW58106.1 - 0.033 14.4 5.5 0.033 14.4 5.5 4.5 1 1 3 4 4 4 0 Calcium-binding EGF domain PsbP PF01789.16 CDW58106.1 - 0.13 12.4 1.5 0.22 11.6 1.5 1.4 1 0 0 1 1 1 0 PsbP RNA_pol_Rpb2_3 PF04565.16 CDW58106.1 - 0.24 11.6 1.2 0.54 10.5 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 3 EGF_2 PF07974.13 CDW58106.1 - 4.3 7.8 50.9 1.2 9.5 8.4 4.5 4 0 0 4 4 4 0 EGF-like domain Rap_GAP PF02145.15 CDW58107.1 - 4.3e-37 127.5 0.0 1.6e-36 125.6 0.0 1.9 2 0 0 2 2 2 1 Rap/ran-GAP Ank_2 PF12796.7 CDW58108.1 - 1.2e-15 57.8 0.1 1.9e-06 28.4 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW58108.1 - 5.7e-15 55.2 0.4 1.4e-07 31.6 0.2 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Death PF00531.22 CDW58108.1 - 2.1e-14 53.4 0.0 6.2e-14 51.9 0.0 1.9 1 0 0 1 1 1 1 Death domain Ank_4 PF13637.6 CDW58108.1 - 2.3e-12 47.1 0.6 0.00018 22.0 0.0 4.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW58108.1 - 1.2e-11 43.7 0.7 0.00032 20.9 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CDW58108.1 - 3.8e-09 36.6 3.8 0.0039 17.6 0.2 4.5 5 0 0 5 5 5 2 Ankyrin repeat Roc PF08477.13 CDW58108.1 - 0.0099 16.1 0.0 8.2 6.7 0.0 2.7 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase COR PF16095.5 CDW58108.1 - 0.016 15.1 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain AAA_16 PF13191.6 CDW58108.1 - 0.04 14.3 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Urb2 PF10441.9 CDW58108.1 - 0.044 13.7 1.0 5.3 6.9 0.5 2.5 2 0 0 2 2 2 0 Urb2/Npa2 family Imm19 PF15563.6 CDW58108.1 - 0.12 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 19 AAA_29 PF13555.6 CDW58108.1 - 0.17 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ank_2 PF12796.7 CDW58109.1 - 5.1e-20 71.9 7.0 4.2e-14 52.9 2.6 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW58109.1 - 2.5e-18 66.2 2.9 1.3e-08 35.2 0.2 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW58109.1 - 5.8e-17 60.0 5.2 0.0009 19.5 0.2 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 CDW58109.1 - 8.5e-14 51.4 8.7 5.6e-06 26.5 1.2 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 CDW58109.1 - 1.9e-11 43.9 9.8 0.00078 19.8 0.2 4.3 4 0 0 4 4 4 3 Ankyrin repeat TRAUB PF08164.12 CDW58110.1 - 6.5e-26 90.7 0.0 6.5e-26 90.7 0.0 2.3 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal NifU PF01106.17 CDW58110.1 - 2.1e-21 75.9 0.3 1.8e-13 50.5 0.0 2.5 2 0 0 2 2 2 2 NifU-like domain Nfu_N PF08712.11 CDW58110.1 - 2.1e-15 56.5 0.0 1.5e-13 50.6 0.0 2.9 1 1 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal AATF-Che1 PF13339.6 CDW58110.1 - 0.0025 18.5 6.7 0.0025 18.5 6.7 3.0 1 1 1 2 2 2 1 Apoptosis antagonizing transcription factor GSH_synth_ATP PF03917.17 CDW58110.1 - 0.024 13.4 0.0 0.038 12.8 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain Anoct_dimer PF16178.5 CDW58110.1 - 0.66 9.7 7.3 0.3 10.8 4.4 1.8 2 0 0 2 2 2 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Kelch_1 PF01344.25 CDW58111.1 - 3.5e-67 221.8 13.0 9.6e-15 53.9 0.2 6.3 6 0 0 6 6 6 6 Kelch motif BACK PF07707.15 CDW58111.1 - 2.8e-30 104.5 2.3 6.1e-30 103.4 0.5 2.3 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_6 PF13964.6 CDW58111.1 - 7.2e-29 99.1 6.4 1.5e-07 31.4 0.0 6.4 1 1 5 6 6 6 6 Kelch motif BTB PF00651.31 CDW58111.1 - 6.6e-21 74.6 2.6 4.1e-20 72.1 0.8 2.9 2 2 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 CDW58111.1 - 2.2e-18 65.4 9.5 1.2e-06 28.2 0.1 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 CDW58111.1 - 1.4e-14 53.8 9.3 0.011 15.8 0.0 6.4 4 2 2 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 CDW58111.1 - 1.3e-13 50.9 6.0 0.0088 16.3 0.0 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CDW58111.1 - 0.00014 21.8 4.5 4.8 7.3 0.0 5.4 5 0 0 5 5 5 1 Kelch motif Ig_3 PF13927.6 CDW58112.1 - 1.7e-16 60.5 0.0 9.9e-10 38.9 0.0 2.8 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 CDW58112.1 - 1e-15 57.8 0.0 8.8e-10 38.8 0.0 2.7 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 CDW58112.1 - 1.5e-13 50.6 0.0 2e-09 37.4 0.0 3.7 3 1 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 CDW58112.1 - 2.2e-11 43.8 0.0 6.2e-09 35.9 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin domain Kazal_2 PF07648.15 CDW58112.1 - 8.4e-11 41.8 7.3 8.4e-11 41.8 7.3 2.5 3 0 0 3 3 2 1 Kazal-type serine protease inhibitor domain EF-hand_5 PF13202.6 CDW58112.1 - 2.4e-09 36.3 1.0 0.0019 17.6 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 CDW58112.1 - 2.7e-09 35.9 0.6 0.0017 17.7 0.0 2.5 2 0 0 2 2 2 2 EF hand Kazal_1 PF00050.21 CDW58112.1 - 5.6e-09 35.9 7.8 1.7e-08 34.3 7.8 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain EF-hand_6 PF13405.6 CDW58112.1 - 6e-08 32.0 0.2 0.003 17.4 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain V-set PF07686.17 CDW58112.1 - 4.5e-06 26.8 4.4 0.017 15.3 0.0 4.7 4 2 1 5 5 4 2 Immunoglobulin V-set domain EF-hand_7 PF13499.6 CDW58112.1 - 8.9e-06 26.1 0.3 2.5e-05 24.6 0.3 1.9 1 1 0 1 1 1 1 EF-hand domain pair Izumo-Ig PF16706.5 CDW58112.1 - 3.8e-05 23.6 0.0 0.00014 21.9 0.0 1.9 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain EF-hand_8 PF13833.6 CDW58112.1 - 0.00015 21.5 0.4 0.0029 17.4 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair Ig_4 PF16680.5 CDW58112.1 - 0.0032 17.7 0.0 0.012 15.8 0.0 2.1 1 0 0 1 1 1 1 T-cell surface glycoprotein CD3 delta chain Dockerin_1 PF00404.18 CDW58112.1 - 0.038 14.2 0.1 6.4 7.1 0.0 2.5 2 0 0 2 2 2 0 Dockerin type I domain EF-hand_4 PF12763.7 CDW58112.1 - 0.1 12.5 0.4 7.6 6.5 0.0 3.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Plasmod_Pvs28 PF06247.11 CDW58112.1 - 3.2 8.1 10.7 6.4 7.2 8.8 2.6 2 0 0 2 2 2 0 Pvs28 EGF domain PAN_1 PF00024.26 CDW58113.1 - 1.1e-19 70.2 19.4 1.5e-11 44.1 1.9 3.6 3 0 0 3 3 3 3 PAN domain PAN_4 PF14295.6 CDW58113.1 - 0.00099 19.0 14.0 0.22 11.4 0.3 3.8 3 1 0 3 3 3 3 PAN domain G10 PF01125.17 CDW58114.1 - 0.029 14.1 0.0 0.82 9.4 0.0 2.3 2 0 0 2 2 2 0 G10 protein Metallophos PF00149.28 CDW58115.1 - 3.1e-30 106.2 0.0 4.1e-30 105.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EGF PF00008.27 CDW58116.1 - 2.9e-39 133.0 156.4 2.7e-06 27.6 6.6 10.7 10 0 0 10 10 10 10 EGF-like domain EGF_CA PF07645.15 CDW58116.1 - 4e-27 94.1 169.5 1.1e-07 31.9 12.6 10.6 4 2 6 10 10 10 9 Calcium-binding EGF domain hEGF PF12661.7 CDW58116.1 - 1.8e-17 63.2 135.3 0.0015 19.1 5.2 11.7 11 0 0 11 11 11 9 Human growth factor-like EGF EGF_2 PF07974.13 CDW58116.1 - 4.6e-14 52.5 179.9 0.0037 17.6 12.8 10.5 10 0 0 10 10 10 8 EGF-like domain FXa_inhibition PF14670.6 CDW58116.1 - 1.2e-06 28.6 140.5 0.063 13.6 10.3 10.7 5 3 5 10 10 10 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW58116.1 - 5.1e-06 26.6 165.5 0.0024 18.1 14.7 11.4 9 1 1 10 10 10 8 EGF domain tRNA-synt_2c PF01411.19 CDW58118.1 - 1.1e-204 681.0 0.0 1.7e-204 680.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CDW58118.1 - 7.2e-14 51.6 0.3 1.6e-13 50.5 0.3 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CDW58118.1 - 3.3e-08 34.1 0.1 8e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 DHHA1 domain VGPC1_C PF16799.5 CDW58118.1 - 0.095 12.7 0.6 0.23 11.5 0.6 1.6 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 RdRP_3 PF00998.23 CDW58118.1 - 0.25 10.0 1.4 0.35 9.5 0.3 1.7 2 0 0 2 2 2 0 Viral RNA dependent RNA polymerase Trypsin PF00089.26 CDW58119.1 - 3.5e-20 72.8 0.0 7.5e-10 39.0 0.0 2.5 2 0 0 2 2 2 2 Trypsin CiPC PF15800.5 CDW58119.1 - 0.043 13.5 14.3 0.065 13.0 14.3 1.2 1 0 0 1 1 1 0 Clock interacting protein circadian Apt1 PF10351.9 CDW58119.1 - 1.1 8.0 11.5 1.6 7.5 11.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CDW58119.1 - 8.8 4.7 11.2 12 4.3 11.2 1.1 1 0 0 1 1 1 0 Macoilin family LIM PF00412.22 CDW58120.1 - 6.9e-14 51.8 29.9 1.7e-10 41.0 8.1 2.4 2 1 0 2 2 2 2 LIM domain zf_UBZ PF18439.1 CDW58120.1 - 0.096 12.3 0.6 0.096 12.3 0.6 3.9 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger WD40 PF00400.32 CDW58121.1 - 0.026 15.4 0.4 14 6.7 0.6 2.6 2 1 0 2 2 2 0 WD domain, G-beta repeat efThoc1 PF11957.8 CDW58122.1 - 1.3e-11 43.8 0.1 2.2e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Death PF00531.22 CDW58122.1 - 3.3e-06 27.2 0.0 1e-05 25.6 0.0 1.9 1 0 0 1 1 1 1 Death domain FAT PF02259.23 CDW58123.1 - 5.7e-94 315.2 6.3 5.7e-94 315.2 6.3 1.8 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 CDW58123.1 - 6.5e-69 232.5 0.1 1.4e-68 231.4 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 CDW58123.1 - 6.4e-46 156.2 3.6 3.6e-45 153.8 0.0 4.2 4 1 1 5 5 5 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 CDW58123.1 - 6.3e-41 138.8 0.7 6.3e-41 138.8 0.7 4.3 5 0 0 5 5 5 1 FKBP12-rapamycin binding domain FATC PF02260.20 CDW58123.1 - 1e-15 57.2 1.3 2.8e-15 55.8 1.3 1.8 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 CDW58123.1 - 7.3e-09 35.9 4.7 3.4 8.1 0.0 8.8 8 2 2 10 10 9 2 HEAT repeats Vac14_Fab1_bd PF12755.7 CDW58123.1 - 1.2e-06 29.0 2.4 0.58 10.8 0.0 5.3 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 CDW58123.1 - 9.3e-05 22.4 12.4 0.79 10.1 0.0 7.7 9 0 0 9 9 8 2 HEAT repeat TPR_19 PF14559.6 CDW58123.1 - 0.0025 18.3 0.1 7.1 7.2 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat HEAT_EZ PF13513.6 CDW58123.1 - 0.012 16.2 11.5 21 5.7 0.0 8.7 10 0 0 10 10 10 0 HEAT-like repeat TPR_1 PF00515.28 CDW58123.1 - 2 8.4 5.9 4 7.4 0.6 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Hist_deacetyl PF00850.19 CDW58124.1 - 8.4e-21 74.7 0.0 9.3e-21 74.6 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Histone PF00125.24 CDW58125.1 - 2.5e-33 115.2 4.8 3e-33 115.0 4.8 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW58125.1 - 9.1e-05 22.5 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 CDW58125.1 - 0.0062 16.8 0.5 0.018 15.3 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone BRCT_assoc PF12820.7 CDW58125.1 - 0.027 14.3 1.5 0.038 13.8 1.5 1.2 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT CENP-S PF15630.6 CDW58125.1 - 0.077 13.4 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 CENP-S protein SepSecS PF05889.13 CDW58126.1 - 7.9e-06 24.8 0.0 9.7e-06 24.5 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS FERM_M PF00373.18 CDW58127.1 - 1.1e-38 132.2 0.0 2.7e-38 131.0 0.0 1.7 1 1 0 1 1 1 1 FERM central domain Kindlin_2_N PF18124.1 CDW58127.1 - 9.8e-38 128.3 1.2 3.1e-37 126.6 0.7 2.2 2 0 0 2 2 2 1 Kindlin-2 N-terminal domain PH PF00169.29 CDW58127.1 - 6.9e-10 39.4 0.1 1.9e-09 38.0 0.1 1.8 1 0 0 1 1 1 1 PH domain FERM_N PF09379.10 CDW58127.1 - 0.024 14.6 0.0 2.3 8.2 0.0 2.7 2 0 0 2 2 2 0 FERM N-terminal domain MIF4G PF02854.19 CDW58128.1 - 1.3e-05 25.0 0.1 1.6e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 MIF4G domain Vitellogenin_N PF01347.22 CDW58129.1 - 4.8e-102 342.4 12.4 4.8e-102 342.4 12.4 1.7 2 0 0 2 2 2 1 Lipoprotein amino terminal region VWD PF00094.25 CDW58129.1 - 1.9e-20 73.7 0.1 1.9e-20 73.7 0.1 3.7 4 0 0 4 4 4 1 von Willebrand factor type D domain DUF1943 PF09172.11 CDW58129.1 - 6e-20 71.7 0.8 6e-20 71.7 0.8 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1943) HEAT_2 PF13646.6 CDW58129.1 - 0.013 15.8 5.3 0.023 15.1 4.1 2.1 2 0 0 2 2 2 0 HEAT repeats EMC3_TMCO1 PF01956.16 CDW58129.1 - 8.3 6.1 6.1 5.8 6.6 3.2 2.4 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like CN_hydrolase PF00795.22 CDW58130.1 - 3.8e-65 219.8 0.0 5.5e-65 219.3 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HIT PF01230.23 CDW58130.1 - 1.8e-21 76.7 0.0 3.4e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 HIT domain DUF1279 PF06916.13 CDW58130.1 - 2e-13 50.7 0.1 4.2e-13 49.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) DcpS_C PF11969.8 CDW58130.1 - 0.00099 19.6 0.0 0.0019 18.6 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 CDW58130.1 - 0.015 15.2 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 NCE101 PF11654.8 CDW58131.1 - 0.05 13.3 0.4 0.19 11.4 0.1 2.2 2 0 0 2 2 2 0 Non-classical export protein 1 ECSIT PF06239.11 CDW58132.1 - 1.8e-64 217.0 5.3 1.7e-63 213.8 5.3 2.0 1 1 0 1 1 1 1 Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C PF14784.6 CDW58132.1 - 8.6e-36 123.2 0.0 1.4e-35 122.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of the ECSIT protein DUF1731 PF08338.11 CDW58133.1 - 1.1e-18 66.8 0.0 1.8e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 CDW58133.1 - 2.4e-09 37.0 0.0 1.9e-07 30.8 0.0 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CDW58133.1 - 0.042 13.0 0.5 0.081 12.0 0.1 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein TENA_THI-4 PF03070.16 CDW58133.1 - 0.056 13.3 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 TENA/THI-4/PQQC family NAD_binding_4 PF07993.12 CDW58133.1 - 0.16 11.1 0.3 1.4 8.0 0.0 2.2 2 1 0 2 2 2 0 Male sterility protein UAA PF08449.11 CDW58134.1 - 2.2e-66 224.1 25.6 3.5e-42 144.7 10.0 2.1 1 1 1 2 2 2 2 UAA transporter family TPT PF03151.16 CDW58134.1 - 3e-06 26.8 15.5 7.7e-05 22.2 6.3 2.5 1 1 1 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 CDW58134.1 - 2.1e-05 24.7 21.5 0.00047 20.3 8.5 3.2 2 2 0 2 2 2 2 EamA-like transporter family TMEM234 PF10639.9 CDW58134.1 - 0.87 9.6 11.1 0.76 9.8 2.2 2.7 3 1 0 3 3 3 0 Putative transmembrane family 234 DUF202 PF02656.15 CDW58134.1 - 1.4 9.4 7.7 1.8 9.1 0.6 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DNA_methylase PF00145.17 CDW58135.1 - 2.7e-07 30.3 0.0 0.0015 18.0 0.0 2.4 1 1 0 2 2 2 2 C-5 cytosine-specific DNA methylase DUF2259 PF10016.9 CDW58136.1 - 0.013 15.4 0.1 0.017 15.1 0.1 1.1 1 0 0 1 1 1 0 Predicted secreted protein (DUF2259) Ank_2 PF12796.7 CDW58137.1 - 1.5e-27 96.0 3.9 2.2e-10 40.9 0.1 4.3 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 CDW58137.1 - 3.1e-22 78.0 12.6 0.007 16.8 0.1 8.4 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 CDW58137.1 - 3.4e-20 72.1 9.0 4.6e-06 27.1 0.2 6.6 1 1 7 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW58137.1 - 4.1e-20 69.7 12.6 0.007 16.8 0.1 9.0 10 0 0 10 10 10 6 Ankyrin repeat Ank_5 PF13857.6 CDW58137.1 - 1.7e-17 63.2 10.6 5.4e-08 32.9 0.3 5.8 3 1 4 7 7 7 4 Ankyrin repeats (many copies) tRNA_synthFbeta PF17759.1 CDW58138.1 - 1.7e-44 151.8 0.0 2.6e-44 151.2 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 CDW58138.1 - 7.9e-22 77.8 0.0 1.4e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain PhetRS_B1 PF18262.1 CDW58138.1 - 3e-21 75.4 1.3 4e-18 65.4 0.3 3.1 2 1 0 2 2 2 2 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 CDW58138.1 - 3.2e-21 75.4 0.3 2e-18 66.5 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain DUF1759 PF03564.15 CDW58139.1 - 6e-21 74.9 0.5 3e-20 72.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Peptidase_A17 PF05380.13 CDW58139.1 - 2.6e-19 69.8 0.1 5.9e-19 68.6 0.1 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase DUF1758 PF05585.12 CDW58139.1 - 3e-18 66.1 0.0 5.7e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Putative peptidase (DUF1758) RVT_1 PF00078.27 CDW58139.1 - 3e-05 23.6 0.0 6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 CDW58139.1 - 0.00091 19.8 0.1 0.0037 17.9 0.0 2.1 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW58139.1 - 0.017 15.7 0.0 0.098 13.2 0.0 2.4 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease DUF5457 PF17540.2 CDW58139.1 - 0.16 12.1 2.4 0.4 10.8 1.7 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5457) DUF5641 PF18701.1 CDW58140.1 - 2e-32 111.2 6.1 2.3e-32 111.0 3.4 2.5 3 0 0 3 3 3 1 Family of unknown function (DUF5641) Integrase_H2C2 PF17921.1 CDW58140.1 - 9.5e-11 41.6 1.9 3e-10 40.0 1.9 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDW58140.1 - 2.3e-07 31.0 0.0 7.1e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDW58140.1 - 0.008 16.4 2.0 0.025 14.8 2.0 1.9 1 0 0 1 1 1 1 H2C2 zinc finger DDE_3 PF13358.6 CDW58140.1 - 0.078 12.7 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease zf-C2H2 PF00096.26 CDW58141.1 - 7.8e-20 70.2 29.3 2.1e-06 27.9 0.4 5.4 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW58141.1 - 8.8e-18 63.9 24.5 1.9e-07 31.2 1.3 5.3 5 0 0 5 5 5 3 Zinc-finger double domain FOXP-CC PF16159.5 CDW58141.1 - 7.6e-10 39.3 14.9 0.03 15.0 0.1 5.0 1 1 4 5 5 5 3 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CDW58141.1 - 3.1e-08 33.8 27.8 0.0013 19.4 0.3 5.6 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 CDW58141.1 - 0.0054 16.9 13.6 1.8 8.6 1.9 4.0 1 1 3 4 4 4 2 Aberrant zinc-finger zf-Di19 PF05605.12 CDW58141.1 - 0.0097 16.2 12.7 0.065 13.5 1.6 3.3 1 1 3 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 CDW58141.1 - 0.027 14.8 9.0 1.5 9.2 0.1 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 CDW58141.1 - 0.031 14.0 9.9 0.29 11.0 0.2 4.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-met PF12874.7 CDW58141.1 - 0.23 11.9 11.4 0.9 10.0 0.0 4.3 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CDW58141.1 - 1.1 9.3 15.8 0.13 12.3 1.9 4.0 5 0 0 5 5 5 0 C2H2-type zinc finger LIM PF00412.22 CDW58142.1 - 6e-60 199.3 49.9 2.7e-16 59.5 5.3 4.1 4 0 0 4 4 4 4 LIM domain zinc-ribbons_6 PF07191.12 CDW58142.1 - 0.13 12.3 35.5 15 5.6 8.4 5.7 1 1 2 3 3 3 0 zinc-ribbons zf-LYAR PF08790.11 CDW58142.1 - 6 6.9 12.5 10 6.1 1.0 4.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger CTD_bind PF04818.13 CDW58143.1 - 3.5e-09 37.4 0.3 3.5e-09 37.4 0.3 2.6 3 0 0 3 3 3 1 RNA polymerase II-binding domain. zf_UBZ PF18439.1 CDW58143.1 - 0.0071 15.9 0.2 0.0071 15.9 0.2 2.2 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger UvrB_inter PF17757.1 CDW58143.1 - 0.086 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 UvrB interaction domain Tfb4 PF03850.14 CDW58144.1 - 1.8e-17 63.7 13.6 1.5e-16 60.8 13.6 1.9 1 1 0 1 1 1 1 Transcription factor Tfb4 RNase_Zc3h12a PF11977.8 CDW58145.1 - 0.0028 17.5 0.0 0.0041 16.9 0.0 1.2 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Glyco_hydro_18 PF00704.28 CDW58146.1 - 2.3e-168 559.7 10.7 1.8e-87 294.0 3.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 18 CBM_14 PF01607.24 CDW58146.1 - 2.7e-20 72.3 14.2 8.2e-12 45.1 5.0 2.9 2 0 0 2 2 2 2 Chitin binding Peritrophin-A domain DUF382 PF04037.13 CDW58147.1 - 9.4e-60 200.3 1.9 9.4e-60 200.3 1.9 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 CDW58147.1 - 6.1e-20 70.8 5.9 1.8e-19 69.3 5.9 1.9 1 0 0 1 1 1 1 PSP BTB_2 PF02214.22 CDW58148.1 - 3.2e-17 62.7 0.0 6.3e-17 61.7 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 CDW58148.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain zf-B_box PF00643.24 CDW58148.1 - 1 9.6 8.5 0.36 11.0 0.6 2.7 2 0 0 2 2 2 0 B-box zinc finger Pkinase_Tyr PF07714.17 CDW58149.1 - 1.5e-52 178.5 0.0 2.2e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW58149.1 - 3.3e-38 131.6 0.0 5.4e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SAM_KSR1 PF13543.6 CDW58149.1 - 3.4e-15 56.3 1.3 5.5e-15 55.7 1.3 1.3 1 0 0 1 1 1 1 SAM like domain present in kinase suppressor RAS 1 DnaJ PF00226.31 CDW58149.1 - 5.1e-14 52.1 0.0 1e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain C1_1 PF00130.22 CDW58149.1 - 2.5e-06 27.2 4.3 2.5e-06 27.2 4.3 2.3 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 CDW58149.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 Kinase-like NB-ARC PF00931.22 CDW58150.1 - 1.5e-30 106.3 0.0 1.9e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 NB-ARC domain CARD PF00619.21 CDW58150.1 - 2.6e-08 33.8 0.8 6.5e-08 32.5 0.8 1.7 1 0 0 1 1 1 1 Caspase recruitment domain AAA_16 PF13191.6 CDW58150.1 - 3.1e-07 31.0 0.0 8.9e-07 29.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CDW58150.1 - 0.0026 17.7 0.2 0.023 14.6 0.0 2.4 2 1 0 2 2 2 1 NACHT domain CARD_2 PF16739.5 CDW58150.1 - 0.0036 17.3 0.3 0.0084 16.1 0.3 1.6 1 0 0 1 1 1 1 Caspase recruitment domain AAA_22 PF13401.6 CDW58150.1 - 0.0092 16.3 0.0 0.13 12.5 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CDW58150.1 - 0.039 14.1 0.1 0.1 12.7 0.1 1.9 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CDW58150.1 - 0.083 12.1 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 CDW58150.1 - 0.18 12.2 0.0 0.4 11.1 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDW58150.1 - 0.21 12.0 0.0 0.45 10.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase MH2 PF03166.14 CDW58151.1 - 9.2e-75 250.9 0.9 1.2e-74 250.5 0.9 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 CDW58151.1 - 1.1e-42 144.5 4.3 5.3e-42 142.2 0.7 2.5 2 0 0 2 2 2 1 MH1 domain IRF-3 PF10401.9 CDW58151.1 - 0.00025 20.9 0.0 0.00039 20.3 0.0 1.2 1 0 0 1 1 1 1 Interferon-regulatory factor 3 DUF4223 PF13978.6 CDW58151.1 - 0.093 12.7 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4223) Deltameth_res PF16020.5 CDW58152.1 - 6e-10 38.8 0.0 7.4e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Deltamethrin resistance DUF4150 PF13665.6 CDW58152.1 - 0.08 13.1 0.1 0.09 12.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4150) Cyclin_N PF00134.23 CDW58153.1 - 0.00011 22.0 0.2 0.00031 20.5 0.1 1.6 1 1 0 2 2 2 1 Cyclin, N-terminal domain PI3_PI4_kinase PF00454.27 CDW58155.1 - 6.4e-47 160.5 0.1 2.7e-45 155.1 0.1 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CDW58155.1 - 8.3e-13 48.1 4.2 3.1e-07 30.0 0.1 2.5 2 1 1 3 3 3 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) C2 PF00168.30 CDW58155.1 - 4.7e-09 36.5 0.0 8.1e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain PX PF00787.24 CDW58155.1 - 1.3e-05 25.1 4.7 3.7e-05 23.7 4.7 1.7 1 0 0 1 1 1 1 PX domain Pkinase PF00069.25 CDW58156.1 - 4.9e-55 186.7 0.0 6.2e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58156.1 - 1.4e-37 129.4 0.0 1.8e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW58156.1 - 1.3e-07 31.3 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 CDW58156.1 - 0.016 14.3 0.0 0.025 13.6 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 CDW58156.1 - 0.038 12.8 0.1 0.044 12.6 0.1 1.3 1 1 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 CDW58156.1 - 0.052 12.5 0.0 0.086 11.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 CDW58156.1 - 0.075 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family gag-asp_proteas PF13975.6 CDW58158.1 - 2.4e-08 34.4 0.1 1e-07 32.4 0.0 1.9 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW58158.1 - 4e-07 30.6 0.0 8.1e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 CDW58158.1 - 0.002 17.9 0.2 0.0053 16.5 0.2 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease DUF1758 PF05585.12 CDW58158.1 - 0.11 12.2 1.1 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 Putative peptidase (DUF1758) MtN3_slv PF03083.16 CDW58159.1 - 0.0046 17.0 7.7 0.16 12.0 3.6 3.0 2 1 1 3 3 3 2 Sugar efflux transporter for intercellular exchange Syndecan PF01034.20 CDW58159.1 - 0.028 14.3 0.5 0.058 13.3 0.5 1.4 1 0 0 1 1 1 0 Syndecan domain DUF2754 PF10953.8 CDW58159.1 - 0.03 14.6 1.8 0.54 10.5 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2754) Homeodomain PF00046.29 CDW58160.1 - 4.6e-23 80.8 7.2 9e-23 79.9 7.2 1.5 1 0 0 1 1 1 1 Homeodomain QLQ PF08880.11 CDW58160.1 - 0.049 13.4 0.2 0.049 13.4 0.2 1.9 2 0 0 2 2 2 0 QLQ SSP160 PF06933.11 CDW58160.1 - 0.081 11.1 6.8 0.091 11.0 6.8 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Homeobox_KN PF05920.11 CDW58160.1 - 0.092 12.7 0.1 0.092 12.7 0.1 1.8 2 0 0 2 2 2 0 Homeobox KN domain PhoLip_ATPase_C PF16212.5 CDW58161.1 - 2.4e-48 165.1 27.6 2.4e-48 165.1 27.6 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CDW58161.1 - 5.2e-14 51.7 0.4 1.5e-13 50.2 0.4 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CDW58161.1 - 3.7e-13 49.4 0.0 5.7e-12 45.6 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CDW58161.1 - 1e-11 44.7 0.0 3.2e-11 43.1 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CDW58161.1 - 1.3e-11 45.2 2.9 0.0001 22.7 0.0 2.9 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDW58161.1 - 0.0022 17.8 0.0 0.0053 16.5 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AAA_25 PF13481.6 CDW58162.1 - 1.2e-18 67.4 0.0 2e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW58162.1 - 2.9e-07 30.8 0.1 9.3e-07 29.2 0.1 1.8 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 CDW58162.1 - 9.7e-07 28.4 0.0 1.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 CDW58162.1 - 4.1e-05 23.0 0.0 7e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 KaiC ABC_tran PF00005.27 CDW58162.1 - 0.0052 17.3 0.0 0.0093 16.5 0.0 1.5 1 1 0 1 1 1 1 ABC transporter T2SSE PF00437.20 CDW58162.1 - 0.0059 15.7 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_23 PF13476.6 CDW58162.1 - 0.0099 16.4 0.2 0.02 15.4 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 CDW58162.1 - 0.017 14.9 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDW58162.1 - 0.022 15.1 0.0 0.043 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CDW58162.1 - 0.027 14.2 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.29 CDW58162.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_7 PF12775.7 CDW58162.1 - 0.086 12.4 0.0 0.2 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NDUF_B12 PF08122.12 CDW58163.1 - 2.4e-09 37.1 0.4 3.7e-09 36.5 0.4 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Vinculin PF01044.19 CDW58164.1 - 3e-71 240.9 7.5 1e-35 123.3 2.7 3.0 2 1 1 3 3 3 3 Vinculin family Drf_FH3 PF06367.16 CDW58164.1 - 0.046 13.3 0.1 0.13 11.9 0.1 1.7 1 0 0 1 1 1 0 Diaphanous FH3 Domain Vps35 PF03635.17 CDW58167.1 - 3e-253 842.7 19.9 3.6e-253 842.4 19.9 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 RelB_N PF18506.1 CDW58167.1 - 0.11 12.3 0.4 16 5.4 0.0 2.8 2 0 0 2 2 2 0 RelB Antitoxin alpha helical domain UPF0086 PF01868.16 CDW58169.1 - 1e-15 57.4 0.0 1.2e-15 57.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Peptidase_U32_C PF16325.5 CDW58169.1 - 0.15 12.3 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase family U32 C-terminal domain NHL PF01436.21 CDW58170.1 - 8.6e-05 22.4 0.1 0.0026 17.7 0.1 2.6 2 0 0 2 2 2 1 NHL repeat IPPT PF01715.17 CDW58171.1 - 3.9e-51 174.1 0.0 5.4e-51 173.6 0.0 1.2 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 CDW58171.1 - 8.9e-05 22.0 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Isopentenyl transferase AAA_33 PF13671.6 CDW58171.1 - 0.0005 20.2 0.0 0.0015 18.7 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CDW58171.1 - 0.012 16.1 0.0 0.021 15.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDW58171.1 - 0.013 15.8 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 CDW58171.1 - 0.032 14.6 0.0 0.067 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 CDW58171.1 - 0.038 14.1 0.1 0.08 13.0 0.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain Zeta_toxin PF06414.12 CDW58171.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ABC_tran PF00005.27 CDW58171.1 - 0.16 12.5 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Metallophos_2 PF12850.7 CDW58172.1 - 3.4e-17 63.1 0.1 4.4e-17 62.8 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CDW58172.1 - 0.069 13.6 0.3 0.14 12.6 0.3 1.7 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase Adaptin_N PF01602.20 CDW58173.1 - 8.8e-163 542.6 13.4 1.2e-162 542.2 13.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CDW58173.1 - 1e-67 227.2 7.7 3.3e-65 219.1 1.4 3.4 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 CDW58173.1 - 1.2e-23 83.3 0.1 3.1e-23 82.0 0.1 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 CDW58173.1 - 9.1e-20 70.8 5.2 1.4e-05 25.4 0.0 5.9 3 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 CDW58173.1 - 1e-12 47.2 7.3 0.0045 17.1 0.0 6.8 6 0 0 6 6 6 3 HEAT repeat Alpha_adaptinC2 PF02883.20 CDW58173.1 - 1.3e-08 35.1 0.1 2.9e-08 34.0 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Arm PF00514.23 CDW58173.1 - 2.4e-06 27.4 4.5 0.37 10.9 0.0 5.7 6 0 0 6 6 5 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 CDW58173.1 - 2.4e-06 27.3 1.4 0.071 12.7 0.1 4.0 2 2 1 3 3 3 2 CLASP N terminal Cnd3 PF12719.7 CDW58173.1 - 3.4e-06 26.5 3.0 2.7e-05 23.5 0.2 2.8 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 CDW58173.1 - 5e-05 23.4 3.6 1.1 9.4 0.0 5.2 2 2 2 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 CDW58173.1 - 0.00094 19.6 0.6 27 5.4 0.0 5.2 4 0 0 4 4 4 0 HEAT-like repeat TIP120 PF08623.10 CDW58173.1 - 0.0011 18.7 9.6 3.3 7.4 0.0 5.1 3 1 3 6 6 6 1 TATA-binding protein interacting (TIP20) Sec7_N PF12783.7 CDW58173.1 - 0.0017 18.3 2.5 0.0047 16.8 0.3 2.9 3 1 1 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal UNC45-central PF11701.8 CDW58173.1 - 0.038 14.0 2.3 0.3 11.1 0.0 3.4 4 1 0 4 4 4 0 Myosin-binding striated muscle assembly central API5 PF05918.11 CDW58173.1 - 0.073 11.9 4.7 0.037 12.8 0.2 2.6 2 1 1 3 3 3 0 Apoptosis inhibitory protein 5 (API5) DUF5578 PF17741.1 CDW58173.1 - 0.091 12.2 3.2 1.7 8.0 0.2 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5578) DUF1390 PF07150.11 CDW58174.1 - 0.082 12.6 2.4 0.13 12.0 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1390) Cys_rich_CPCC PF14206.6 CDW58174.1 - 1.1 9.1 6.8 5 7.0 6.8 2.0 1 1 0 1 1 1 0 Cysteine-rich CPCC EF-hand_7 PF13499.6 CDW58175.1 - 5.2e-29 100.5 4.1 4.2e-17 62.4 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW58175.1 - 2.3e-28 95.6 12.5 5.2e-09 35.0 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 CDW58175.1 - 4.6e-22 76.0 7.6 7.6e-07 28.6 0.1 4.5 3 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CDW58175.1 - 6.9e-22 75.9 11.6 5.3e-08 32.0 0.0 4.7 6 0 0 6 6 6 3 EF hand EF-hand_8 PF13833.6 CDW58175.1 - 1.9e-21 75.7 9.3 4.7e-14 52.0 0.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW58175.1 - 4.5e-12 46.3 0.1 3.2e-09 37.1 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CDW58175.1 - 1.3e-06 28.3 0.7 0.0077 16.2 0.0 2.6 2 2 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CDW58175.1 - 4.9e-06 26.7 2.5 0.0001 22.4 0.0 3.5 2 1 1 3 3 3 1 Dockerin type I domain Caleosin PF05042.13 CDW58175.1 - 0.0016 18.4 0.8 1.3 8.9 0.0 3.4 1 1 3 4 4 4 1 Caleosin related protein VCBS PF13517.6 CDW58175.1 - 0.013 16.1 2.2 20 5.8 0.1 3.6 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TerB PF05099.13 CDW58175.1 - 0.016 15.2 0.0 1 9.3 0.0 2.3 2 1 0 2 2 2 0 Tellurite resistance protein TerB EF-hand_9 PF14658.6 CDW58175.1 - 0.019 15.2 0.1 1.9 8.9 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain UPF0154 PF03672.13 CDW58175.1 - 0.15 12.1 0.0 1.3 9.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) TMEM237 PF15383.6 CDW58176.1 - 2.4e-24 85.8 0.2 3.2e-24 85.4 0.2 1.1 1 0 0 1 1 1 1 Transmembrane protein 237 gag-asp_proteas PF13975.6 CDW58177.1 - 0.0011 19.5 0.0 0.0025 18.3 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.17 CDW58177.1 - 0.0015 18.8 0.0 0.0052 17.0 0.0 1.9 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC_2 PF13696.6 CDW58177.1 - 0.017 14.9 23.3 0.17 11.8 3.4 3.4 3 0 0 3 3 3 0 Zinc knuckle PNMA PF14893.6 CDW58177.1 - 0.021 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 PNMA Asp_protease_2 PF13650.6 CDW58177.1 - 0.03 15.0 0.0 0.076 13.7 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease DUF4810 PF16068.5 CDW58177.1 - 0.089 13.3 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) zf-CCHC PF00098.23 CDW58177.1 - 0.18 11.9 24.9 0.063 13.4 1.7 3.6 3 0 0 3 3 3 0 Zinc knuckle zinc_ribbon_9 PF14369.6 CDW58177.1 - 0.29 11.4 6.2 9.5 6.6 0.1 3.2 3 0 0 3 3 3 0 zinc-ribbon HscB_4_cys PF18256.1 CDW58177.1 - 0.5 10.2 15.9 1 9.2 9.2 2.7 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif Rdx PF10262.9 CDW58177.1 - 1.2 9.3 4.8 34 4.7 4.8 3.2 1 1 0 1 1 1 0 Rdx family Cyanate_lyase PF02560.14 CDW58178.1 - 1.1e-27 95.7 0.0 1.5e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HCO3_cotransp PF00955.21 CDW58179.1 - 2.1e-88 297.4 10.8 8.9e-70 235.9 1.8 2.0 1 1 1 2 2 2 2 HCO3- transporter family YMF19 PF02326.15 CDW58179.1 - 0.52 11.1 4.8 1.6 9.5 4.8 1.8 1 0 0 1 1 1 0 Plant ATP synthase F0 Integrase_H2C2 PF17921.1 CDW58181.1 - 0.00035 20.6 0.9 0.0013 18.8 0.9 1.9 1 1 0 1 1 1 1 Integrase zinc binding domain Asp_protease_2 PF13650.6 CDW58181.1 - 0.042 14.5 0.0 0.089 13.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease Alg14 PF08660.11 CDW58182.1 - 2.6e-55 187.0 0.0 3.3e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Pkinase PF00069.25 CDW58183.1 - 1.2e-58 198.6 0.0 2.2e-58 197.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58183.1 - 8e-33 113.8 0.0 1.2e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW58183.1 - 0.0058 16.0 0.0 0.018 14.4 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family SMN PF06003.12 CDW58184.1 - 2.4e-10 40.1 0.6 3.5e-10 39.6 0.6 1.2 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Aminotran_4 PF01063.19 CDW58185.1 - 1.1e-23 84.3 0.0 1.4e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV HP0268 PF18618.1 CDW58185.1 - 0.092 13.2 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 HP0268 zf-C4 PF00105.18 CDW58186.1 - 6.4e-30 103.4 11.4 6.4e-30 103.4 11.4 2.1 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW58186.1 - 1e-24 87.2 0.2 1.6e-24 86.7 0.2 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor CDP-OH_P_transf PF01066.21 CDW58188.1 - 8.6e-15 55.3 1.3 8.6e-15 55.3 1.3 2.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Methyltransf_12 PF08242.12 CDW58189.1 - 6.4e-10 39.7 0.0 3.7e-09 37.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW58189.1 - 3e-09 36.9 0.0 4.2e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW58189.1 - 8e-09 36.1 0.0 1.4e-08 35.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW58189.1 - 6.1e-08 33.2 0.0 1e-07 32.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW58189.1 - 3.2e-06 26.8 0.0 5.3e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDW58189.1 - 7e-06 25.9 0.0 1.3e-05 25.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDW58189.1 - 0.0043 16.8 0.0 0.0085 15.9 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Rsm22 PF09243.10 CDW58189.1 - 0.051 12.8 0.0 0.073 12.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 ADAM_CR_2 PF17771.1 CDW58190.1 - 0.095 13.2 5.2 0.36 11.4 5.2 2.1 1 1 0 1 1 1 0 ADAM cysteine-rich domain Aminotran_1_2 PF00155.21 CDW58192.1 - 3.8e-32 111.9 0.0 1.1e-31 110.4 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CDW58192.1 - 0.062 12.6 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase MFS_1 PF07690.16 CDW58195.1 - 2.1e-46 158.5 27.4 3.2e-44 151.3 22.8 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily PalH PF08733.10 CDW58195.1 - 0.00074 18.6 3.1 0.00074 18.6 3.1 2.1 2 0 0 2 2 2 1 PalH/RIM21 MFS_1 PF07690.16 CDW58196.1 - 1.7e-51 175.2 44.1 2.3e-51 174.8 33.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW58196.1 - 1.2e-12 47.5 12.1 1.2e-12 47.5 12.1 2.2 2 1 0 2 2 2 1 Sugar (and other) transporter Adipogenin PF15202.6 CDW58197.1 - 0.15 12.1 0.9 0.62 10.1 0.0 2.1 2 0 0 2 2 2 0 Adipogenin Toxin_TOLIP PF00087.21 CDW58197.1 - 0.16 12.2 18.4 0.045 14.0 15.3 1.7 1 1 0 1 1 1 0 Snake toxin and toxin-like protein CUB PF00431.20 CDW58198.1 - 6.7e-32 110.1 0.0 9.7e-20 71.0 0.0 2.8 3 0 0 3 3 3 2 CUB domain Ldl_recept_a PF00057.18 CDW58198.1 - 1.5e-08 34.7 5.9 3.3e-08 33.6 5.9 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A TPR_19 PF14559.6 CDW58199.1 - 4.5e-34 116.8 9.3 3.7e-05 24.2 0.0 10.8 8 2 3 11 11 11 9 Tetratricopeptide repeat TPR_1 PF00515.28 CDW58199.1 - 1.2e-28 97.7 31.5 3.1e-06 26.8 0.0 12.9 15 0 0 15 15 14 7 Tetratricopeptide repeat TPR_17 PF13431.6 CDW58199.1 - 2e-28 96.7 21.9 0.004 17.4 0.0 14.9 15 1 1 16 16 15 8 Tetratricopeptide repeat TPR_2 PF07719.17 CDW58199.1 - 5e-25 85.6 33.8 0.00039 20.3 0.0 15.0 16 0 0 16 16 15 6 Tetratricopeptide repeat TPR_14 PF13428.6 CDW58199.1 - 1.2e-21 75.5 13.2 0.017 15.9 0.0 12.2 10 3 3 13 13 12 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDW58199.1 - 1.1e-20 72.0 29.9 0.0061 16.7 0.0 14.7 16 0 0 16 16 15 6 Tetratricopeptide repeat TPR_11 PF13414.6 CDW58199.1 - 4.4e-20 71.1 16.7 0.0034 17.0 0.0 11.0 7 3 3 10 10 10 6 TPR repeat TPR_16 PF13432.6 CDW58199.1 - 4.9e-20 71.9 6.3 0.02 15.5 0.7 9.8 6 3 5 11 11 11 6 Tetratricopeptide repeat TPR_6 PF13174.6 CDW58199.1 - 1.7e-12 47.1 28.1 0.00085 19.8 0.0 11.4 12 0 0 12 12 11 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDW58199.1 - 9e-12 45.1 30.2 0.0068 16.7 0.3 11.2 9 5 4 14 14 13 4 Tetratricopeptide repeat TPR_9 PF13371.6 CDW58199.1 - 4.7e-07 29.9 0.6 1.8 8.8 0.0 6.8 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 CDW58199.1 - 6.9e-07 28.9 24.6 3 7.8 0.0 10.1 11 0 0 11 11 11 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW58199.1 - 1.5e-06 28.3 12.6 0.96 9.7 0.0 6.8 5 1 1 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 CDW58199.1 - 0.00015 22.0 0.7 0.36 11.6 0.6 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat Rapsyn_N PF10579.9 CDW58199.1 - 0.00062 19.8 0.3 4 7.6 0.0 5.2 5 1 1 6 6 5 1 Rapsyn N-terminal myristoylation and linker region TPR_7 PF13176.6 CDW58199.1 - 0.0014 18.5 30.0 1.8 8.7 0.0 10.5 12 0 0 12 12 9 2 Tetratricopeptide repeat TPPII_N PF12583.8 CDW58199.1 - 0.023 15.3 2.0 0.17 12.5 0.0 2.8 3 0 0 3 3 2 0 Tripeptidyl peptidase II N terminal DUF4919 PF16266.5 CDW58199.1 - 0.086 12.8 1.9 0.45 10.4 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) HEPN_Toprim_N PF18871.1 CDW58199.1 - 0.28 11.1 5.0 5.8 6.8 4.3 2.6 2 0 0 2 2 2 0 HEPN/Toprim N-terminal domain 1 TPR_3 PF07720.12 CDW58199.1 - 0.94 9.5 6.8 1.4 9.0 0.9 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1465 PF07323.12 CDW58200.1 - 0.04 13.7 0.0 0.16 11.8 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1465) ODC_AZ PF02100.17 CDW58201.1 - 1e-10 41.6 0.0 1.2e-10 41.3 0.0 1.0 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Motile_Sperm PF00635.26 CDW58202.1 - 6.2e-24 83.9 0.8 1.3e-23 82.9 0.6 1.6 1 1 1 2 2 2 1 MSP (Major sperm protein) domain APG6_N PF17675.1 CDW58202.1 - 0.0015 19.0 1.5 0.0021 18.6 1.5 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region bZIP_1 PF00170.21 CDW58202.1 - 0.0066 16.5 3.9 0.062 13.4 1.9 2.2 1 1 1 2 2 2 2 bZIP transcription factor Rootletin PF15035.6 CDW58202.1 - 0.011 15.7 0.2 0.013 15.5 0.2 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion ZapB PF06005.12 CDW58202.1 - 0.014 15.8 1.5 0.024 15.1 1.5 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF3450 PF11932.8 CDW58202.1 - 0.03 13.6 0.4 0.047 13.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) LRRFIP PF09738.9 CDW58202.1 - 0.031 13.8 0.7 0.043 13.3 0.7 1.2 1 0 0 1 1 1 0 LRRFIP family Csm1_N PF18504.1 CDW58202.1 - 0.033 14.5 0.5 0.033 14.5 0.5 1.7 2 0 0 2 2 2 0 Csm1 N-terminal domain SKA2 PF16740.5 CDW58202.1 - 0.05 13.4 0.1 0.09 12.6 0.1 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 HAP1_N PF04849.13 CDW58202.1 - 0.07 12.3 3.2 0.14 11.4 3.2 1.5 1 1 0 1 1 1 0 HAP1 N-terminal conserved region ASH PF15780.5 CDW58202.1 - 0.073 13.3 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin GIT_CC PF16559.5 CDW58202.1 - 0.1 12.5 2.0 11 6.0 0.2 3.1 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_2 PF07716.15 CDW58202.1 - 0.16 12.1 3.5 0.43 10.7 2.5 2.0 1 1 1 2 2 2 0 Basic region leucine zipper Cep57_CLD_2 PF14197.6 CDW58202.1 - 0.16 12.1 4.9 0.32 11.1 4.9 1.5 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 7tm_1 PF00001.21 CDW58203.1 - 0.036 13.4 20.3 0.05 12.9 20.3 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) 7tm_1 PF00001.21 CDW58204.1 - 0.0074 15.6 16.5 0.01 15.2 16.5 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF2733 PF10813.8 CDW58204.1 - 0.15 11.8 0.7 2.3 8.1 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2733) Globin PF00042.22 CDW58205.1 - 2e-09 38.0 0.1 2.8e-09 37.5 0.1 1.2 1 0 0 1 1 1 1 Globin SUa-2TM PF18179.1 CDW58205.1 - 0.064 12.5 0.2 0.076 12.3 0.2 1.1 1 0 0 1 1 1 0 SMODS- and Ubiquitin system-associated 2TM effector domain AMP-binding PF00501.28 CDW58206.1 - 2.7e-46 158.0 0.0 3.5e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme HhH-GPD PF00730.25 CDW58208.1 - 7.9e-20 71.3 0.0 1.1e-19 70.8 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDW58208.1 - 3.2e-09 36.2 0.0 1.3e-08 34.3 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_8 PF14716.6 CDW58208.1 - 0.17 12.2 0.0 0.68 10.4 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain Histone PF00125.24 CDW58209.1 - 9.9e-11 42.1 0.9 2.9e-10 40.6 0.1 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 DUF743 PF05332.11 CDW58209.1 - 0.043 13.9 0.2 0.08 13.0 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF743) Histone PF00125.24 CDW58210.1 - 4e-29 101.6 0.4 7.1e-29 100.8 0.4 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW58210.1 - 0.0066 16.6 0.7 0.25 11.5 0.0 2.2 1 1 1 2 2 2 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 CDW58210.1 - 0.025 14.7 0.2 0.037 14.1 0.2 1.4 1 1 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit RGS_DHEX PF18148.1 CDW58210.1 - 0.071 13.2 0.2 0.12 12.5 0.2 1.3 1 0 0 1 1 1 0 Regulator of G-protein signalling DHEX domain ANAPC5 PF12862.7 CDW58210.1 - 0.092 12.8 0.0 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 DUF1758 PF05585.12 CDW58211.1 - 0.0048 16.7 0.1 0.01 15.6 0.1 1.5 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 CDW58211.1 - 0.011 16.4 0.0 0.029 15.0 0.0 1.7 2 0 0 2 2 2 0 Aspartyl protease Peptidase_A2B PF12384.8 CDW58211.1 - 0.014 14.9 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 Ty3 transposon peptidase AnfO_nitrog PF09582.10 CDW58211.1 - 0.054 12.8 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) gag-asp_proteas PF13975.6 CDW58211.1 - 0.12 12.9 0.1 0.35 11.4 0.0 1.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease DUF4699 PF15770.5 CDW58213.1 - 0.088 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4699) WD40 PF00400.32 CDW58214.1 - 1.8e-43 145.7 12.2 1.1e-07 32.4 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW58214.1 - 4.6e-19 68.5 2.5 0.0094 16.2 0.0 6.2 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW58214.1 - 0.00063 19.2 0.0 0.047 13.0 0.0 2.6 2 1 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 CDW58214.1 - 0.0028 16.7 0.1 0.96 8.3 0.0 2.3 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SBD PF17882.1 CDW58214.1 - 0.01 15.6 0.6 1.8 8.4 0.0 2.8 2 1 0 3 3 3 0 OAA-family lectin sugar binding domain Rpn3_C PF08375.11 CDW58214.1 - 0.023 15.1 0.3 32 5.0 0.0 3.5 4 0 0 4 4 4 0 Proteasome regulatory subunit C-terminal rve PF00665.26 CDW58215.1 - 4.8e-05 23.5 0.0 6.3e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain VirB7 PF17413.2 CDW58215.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Outer membrane lipoprotein virB7 RT_RNaseH_2 PF17919.1 CDW58216.1 - 1e-10 41.5 0.1 1.7e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDW58216.1 - 0.0038 17.5 0.0 0.0071 16.6 0.0 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DHR-2 PF06920.13 CDW58217.1 - 9.3e-70 235.7 0.5 5.6e-57 193.6 0.0 2.3 1 1 1 2 2 2 2 Dock homology region 2 DOCK-C2 PF14429.6 CDW58217.1 - 6e-47 160.0 0.8 3.4e-46 157.5 0.8 2.2 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 CDW58217.1 - 6.6e-11 41.7 0.0 2.6e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 DOCK N-terminus Metallophos PF00149.28 CDW58218.1 - 9e-36 124.3 0.1 1.3e-35 123.7 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW58218.1 - 0.00031 21.1 0.2 0.00088 19.7 0.2 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain DOCK_N PF16172.5 CDW58219.1 - 6.9e-20 71.3 0.4 8.6e-20 71.0 0.4 1.0 1 0 0 1 1 1 1 DOCK N-terminus Rpn9_C PF18261.1 CDW58219.1 - 0.12 12.0 0.3 3.5 7.3 0.0 2.5 2 0 0 2 2 2 0 Rpn9 C-terminal helix S10_plectin PF03501.15 CDW58220.1 - 5.9e-47 157.7 0.3 7e-47 157.5 0.3 1.0 1 0 0 1 1 1 1 Plectin/S10 domain TFIIE_alpha PF02002.17 CDW58220.1 - 0.11 12.3 0.5 0.15 11.9 0.5 1.2 1 0 0 1 1 1 0 TFIIE alpha subunit DUF1325 PF07039.11 CDW58221.1 - 2.8e-29 101.9 0.0 5.5e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 SGF29 tudor-like domain OST3_OST6 PF04756.13 CDW58221.1 - 6.1e-08 32.4 2.2 9e-08 31.8 2.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TUDOR PF00567.24 CDW58221.1 - 0.0052 16.8 0.6 0.89 9.6 0.6 2.7 1 1 0 2 2 2 1 Tudor domain DUF4537 PF15057.6 CDW58221.1 - 0.007 16.4 0.0 2.3 8.3 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4537) Tudor_3 PF18115.1 CDW58221.1 - 0.11 12.4 0.5 0.23 11.3 0.0 1.8 2 0 0 2 2 2 0 DNA repair protein Crb2 Tudor domain FliE PF02049.18 CDW58221.1 - 0.25 11.5 1.9 0.51 10.5 0.8 2.1 2 1 1 3 3 3 0 Flagellar hook-basal body complex protein FliE Auto_anti-p27 PF06677.12 CDW58222.1 - 2.1e-11 43.8 7.0 3.5e-11 43.1 7.0 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF4769 PF15992.5 CDW58222.1 - 0.069 12.9 0.0 0.085 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) RGS-like PF09128.11 CDW58222.1 - 0.096 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain FAR1 PF03101.15 CDW58225.1 - 0.049 14.3 0.6 0.18 12.5 0.1 2.1 2 0 0 2 2 2 0 FAR1 DNA-binding domain Cation_ATPase_C PF00689.21 CDW58226.1 - 4.5e-44 150.3 6.3 9.8e-44 149.2 6.3 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CDW58226.1 - 3.5e-43 147.2 0.4 3.5e-43 147.2 0.4 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 CDW58226.1 - 3.8e-21 75.0 0.3 7e-21 74.1 0.3 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDW58226.1 - 5.6e-21 75.8 0.2 7.2e-20 72.2 0.2 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDW58226.1 - 1.2e-07 31.8 0.9 1.3e-06 28.3 0.4 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW58226.1 - 2.1e-05 25.0 0.0 9.9e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF3810 PF12725.7 CDW58226.1 - 0.0074 15.7 3.4 0.015 14.6 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3810) DUF3721 PF12518.8 CDW58226.1 - 0.12 12.2 0.9 0.57 10.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function RRM_1 PF00076.22 CDW58227.1 - 8.7e-37 124.8 0.0 3.4e-13 49.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CDW58227.1 - 0.0073 16.4 0.0 0.51 10.4 0.0 3.1 3 1 0 3 3 3 1 Limkain b1 RRM_3 PF08777.11 CDW58227.1 - 0.036 14.1 0.0 5.3 7.2 0.0 2.8 3 0 0 3 3 3 0 RNA binding motif RRM_5 PF13893.6 CDW58227.1 - 0.079 12.5 0.0 0.3 10.7 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dynamin_N PF00350.23 CDW58228.1 - 1.3e-12 48.1 2.1 6e-11 42.7 0.0 3.1 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CDW58228.1 - 1e-08 35.2 0.0 2.7e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDW58228.1 - 3.8e-08 33.1 0.0 4.4e-07 29.6 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 CDW58228.1 - 3.8e-06 26.4 0.1 1.6e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 AIG1 family EF-hand_4 PF12763.7 CDW58228.1 - 9.7e-06 25.5 0.0 2.7e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand PduV-EutP PF10662.9 CDW58228.1 - 0.01 15.6 0.0 0.51 10.1 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 CDW58228.1 - 0.017 14.7 0.1 7.2 6.1 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B Gtr1_RagA PF04670.12 CDW58228.1 - 0.017 14.5 0.0 0.044 13.1 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region EF-hand_1 PF00036.32 CDW58228.1 - 0.019 14.5 0.1 0.051 13.1 0.1 1.7 1 0 0 1 1 1 0 EF hand AAA_16 PF13191.6 CDW58228.1 - 0.034 14.5 0.0 0.11 12.9 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CDW58228.1 - 0.04 13.8 0.6 6.5 6.6 0.0 3.1 2 1 0 3 3 3 0 RsgA GTPase AAA_28 PF13521.6 CDW58228.1 - 0.059 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CDW58228.1 - 0.1 12.2 0.0 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CDW58228.1 - 0.41 10.9 0.0 0.41 10.9 0.0 2.7 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase EOS1 PF12326.8 CDW58228.1 - 0.76 9.7 4.0 1.2 9.0 4.0 1.3 1 0 0 1 1 1 0 N-glycosylation protein Coilin_N PF15862.5 CDW58228.1 - 7 6.5 18.0 0.26 11.1 11.7 1.9 2 0 0 2 2 2 0 Coilin N-terminus His_Phos_1 PF00300.22 CDW58229.1 - 2.4e-07 30.6 0.0 4e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SLT PF01464.20 CDW58230.1 - 1e-17 63.8 4.0 2.1e-17 62.8 2.6 2.2 2 0 0 2 2 2 1 Transglycosylase SLT domain HHH_9 PF17674.1 CDW58230.1 - 0.0039 18.1 1.2 0.68 10.9 0.0 4.6 3 0 0 3 3 3 1 HHH domain BppL_N PF18338.1 CDW58230.1 - 0.27 11.1 4.3 0.25 11.2 1.5 2.5 3 0 0 3 3 3 0 Lower baseplate protein N-terminal domain Glucosaminidase PF01832.20 CDW58230.1 - 0.54 10.8 3.2 12 6.5 3.2 3.2 1 1 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Pyr_redox_2 PF07992.14 CDW58231.1 - 1.8e-05 24.1 0.0 0.013 14.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Cons_hypoth95 PF03602.15 CDW58231.1 - 0.072 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 NfI_DNAbd_pre-N PF10524.9 CDW58232.1 - 6.5e-17 61.1 1.1 1.1e-16 60.4 1.1 1.3 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.16 CDW58232.1 - 2.9e-13 49.9 0.1 4.9e-13 49.2 0.1 1.4 1 0 0 1 1 1 1 MH1 domain BPL_C PF02237.17 CDW58235.1 - 7.2e-09 35.4 0.0 1.5e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain BPL_LplA_LipB PF03099.19 CDW58235.1 - 6e-07 29.4 0.0 1.3e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Band_7 PF01145.25 CDW58236.1 - 1.1e-24 87.4 2.6 1.1e-24 87.4 2.6 1.6 1 1 1 2 2 2 1 SPFH domain / Band 7 family Med2 PF11214.8 CDW58236.1 - 0.042 14.0 0.4 0.07 13.3 0.4 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 Band_7_1 PF13421.6 CDW58236.1 - 0.089 12.5 1.0 0.21 11.3 0.3 1.8 1 1 1 2 2 2 0 SPFH domain-Band 7 family MPC PF03650.13 CDW58239.1 - 2.5e-35 120.9 0.4 2.8e-35 120.8 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers GluR_Homer-bdg PF10606.9 CDW58240.1 - 0.042 14.1 0.3 0.16 12.2 0.3 2.0 1 0 0 1 1 1 0 Homer-binding domain of metabotropic glutamate receptor Neuropep_like PF15161.6 CDW58240.1 - 0.11 12.2 0.4 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 Neuropeptide-like G-patch PF01585.23 CDW58242.1 - 1.1e-13 50.8 1.1 2.8e-13 49.5 1.1 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CDW58242.1 - 4.9e-06 26.5 1.4 2.1e-05 24.5 1.4 2.1 1 1 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 CDW58242.1 - 1.1e-05 24.6 1.9 2.4e-05 23.6 1.9 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 CDW58242.1 - 0.00055 19.7 0.0 0.0015 18.3 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OCRE PF17780.1 CDW58242.1 - 0.0065 16.5 1.2 0.019 15.0 1.2 1.8 1 0 0 1 1 1 1 OCRE domain RED_N PF07808.13 CDW58242.1 - 0.0069 16.0 0.1 0.0069 16.0 0.1 2.6 3 0 0 3 3 3 1 RED-like protein N-terminal region zf-C2H2_2 PF12756.7 CDW58242.1 - 0.033 14.5 0.2 0.15 12.4 0.2 2.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CDW58242.1 - 0.052 13.8 1.9 0.086 13.1 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW58242.1 - 0.13 12.7 1.5 1 9.9 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Spectrin PF00435.21 CDW58244.1 - 6.4e-21 74.8 72.4 3.7e-08 33.8 3.0 10.8 8 2 4 12 12 12 6 Spectrin repeat DivIVA PF05103.13 CDW58244.1 - 0.0046 17.0 0.9 0.0046 17.0 0.9 7.7 7 2 3 10 10 10 1 DivIVA protein DUF4419 PF14388.6 CDW58244.1 - 0.0076 15.7 0.0 0.045 13.2 0.0 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) P22_AR_C PF10548.9 CDW58244.1 - 0.019 15.2 0.9 3.4 7.9 0.1 4.0 4 0 0 4 4 4 0 P22AR C-terminal domain Cob_adeno_trans PF01923.18 CDW58244.1 - 0.18 11.9 0.1 0.18 11.9 0.1 6.7 3 1 1 6 6 6 0 Cobalamin adenosyltransferase Syntaxin_2 PF14523.6 CDW58244.1 - 2.6 8.5 0.0 2.6 8.5 0.0 9.4 6 2 5 12 12 12 0 Syntaxin-like protein NPV_P10 PF05531.12 CDW58244.1 - 3 8.4 31.2 6.6 7.3 1.4 10.1 7 5 4 11 11 11 0 Nucleopolyhedrovirus P10 protein Med29 PF11568.8 CDW58244.1 - 4.3 7.6 11.6 2.4 8.4 0.8 4.2 3 1 0 3 3 3 0 Mediator complex subunit 29 DUF3683 PF12447.8 CDW58244.1 - 5.7 7.1 8.8 0.93 9.6 0.7 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3683) FAA_hydro_N_2 PF18288.1 CDW58244.1 - 7.2 7.1 12.7 7 7.1 0.0 6.4 5 2 2 7 7 7 0 Fumarylacetoacetase N-terminal domain 2 Peptidase_M14 PF00246.24 CDW58245.1 - 5.4e-32 111.8 0.0 6e-32 111.6 0.0 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase His_Phos_1 PF00300.22 CDW58246.1 - 4.8e-13 49.2 0.0 1.3e-12 47.8 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RRM_1 PF00076.22 CDW58247.1 - 1.9e-17 62.8 0.0 3.2e-17 62.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW58247.1 - 0.0037 17.1 0.1 0.014 15.3 0.0 1.9 2 1 0 2 2 2 1 Occluded RNA-recognition motif Actin PF00022.19 CDW58248.1 - 3.1e-117 391.6 0.0 3.6e-117 391.4 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CDW58248.1 - 6.8e-05 21.8 0.0 0.011 14.6 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Sec7 PF01369.20 CDW58249.1 - 2.4e-69 232.7 0.0 6.1e-69 231.4 0.0 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CDW58249.1 - 1.5e-34 119.2 29.5 5e-34 117.5 7.4 5.6 5 2 1 6 6 6 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 CDW58249.1 - 4.6e-34 116.1 9.4 5.9e-34 115.8 0.3 5.3 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) DCB PF16213.5 CDW58249.1 - 1.1e-29 103.4 3.5 1.1e-29 103.4 3.5 3.6 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 GDH_N PF12466.8 CDW58249.1 - 0.059 13.6 0.4 2.6 8.3 0.1 3.0 3 0 0 3 3 3 0 Glutamate dehydrogenase N terminal FKBP_N_2 PF18023.1 CDW58249.1 - 0.097 12.8 0.1 0.36 10.9 0.1 2.0 1 0 0 1 1 1 0 BDBT FKBP like N-terminal DUF4116 PF13475.6 CDW58249.1 - 0.61 9.9 2.9 21 4.9 0.2 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4116) Ank_2 PF12796.7 CDW58250.1 - 2e-40 137.2 0.2 1.9e-16 60.4 0.0 3.1 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW58250.1 - 9.8e-32 108.9 5.3 6.5e-10 39.3 0.0 4.7 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW58250.1 - 2.9e-29 97.8 0.3 1.8e-06 27.8 0.1 6.1 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 CDW58250.1 - 4.6e-26 90.1 0.4 8.3e-08 32.3 0.1 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 CDW58250.1 - 2e-20 72.6 1.8 6.2e-05 23.2 0.1 4.3 3 1 1 4 4 4 4 Ankyrin repeats (many copies) TMEM210 PF15195.6 CDW58251.1 - 0.048 14.1 0.2 0.081 13.3 0.0 1.5 2 0 0 2 2 2 0 TMEM210 family His_Phos_1 PF00300.22 CDW58252.1 - 4.7e-13 49.3 0.0 1.3e-12 47.8 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) COPIIcoated_ERV PF07970.12 CDW58253.1 - 5.7e-44 150.6 0.0 8.4e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CDW58253.1 - 4.2e-18 65.5 0.1 9.6e-18 64.3 0.1 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Hint PF01079.20 CDW58254.1 - 4.4e-38 130.9 0.0 6.2e-38 130.4 0.0 1.1 1 0 0 1 1 1 1 Hint module Intein_splicing PF14890.6 CDW58254.1 - 0.00031 20.7 0.0 0.00044 20.2 0.0 1.2 1 0 0 1 1 1 1 Intein splicing domain OATP PF03137.20 CDW58255.1 - 0.0074 14.6 2.1 0.0088 14.4 2.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family EGF PF00008.27 CDW58255.1 - 0.75 10.2 7.9 0.18 12.2 3.2 2.2 1 1 1 2 2 2 0 EGF-like domain DUF1505 PF07403.11 CDW58255.1 - 2.2 8.5 6.3 0.68 10.1 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1505) DUF4603 PF15376.6 CDW58256.1 - 0.0056 14.2 0.6 0.012 13.1 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4603) S-methyl_trans PF02574.16 CDW58257.1 - 4.9e-56 190.5 1.6 6.1e-56 190.2 1.6 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Trypsin PF00089.26 CDW58258.1 - 1.9e-49 168.5 0.0 2.9e-49 167.9 0.0 1.3 1 0 0 1 1 1 1 Trypsin RRM_1 PF00076.22 CDW58258.1 - 2.2e-38 129.9 0.3 1.6e-19 69.5 0.7 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW58258.1 - 1.6e-05 24.5 0.1 0.0051 16.4 0.3 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW58258.1 - 0.00038 20.5 0.2 0.13 12.4 0.1 2.9 2 2 0 2 2 2 1 RNA recognition motif Nup35_RRM PF05172.13 CDW58258.1 - 0.0026 17.7 0.1 0.14 12.1 0.1 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 CDW58258.1 - 0.017 14.9 0.0 0.15 11.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4523) Ribosomal_L13 PF00572.18 CDW58258.1 - 0.11 12.8 0.0 0.44 10.8 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L13 Limkain-b1 PF11608.8 CDW58258.1 - 0.12 12.5 0.1 25 5.0 0.0 2.4 2 0 0 2 2 2 0 Limkain b1 Nup35_RRM_2 PF14605.6 CDW58258.1 - 0.21 11.6 0.4 2.7 8.1 0.1 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif HSP70 PF00012.20 CDW58259.1 - 1.2e-87 294.5 1.6 1.2e-87 294.5 1.6 2.2 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CDW58259.1 - 0.0014 17.5 0.4 0.0033 16.3 0.1 1.7 2 0 0 2 2 2 1 MreB/Mbl protein AbiEi_3_N PF17194.4 CDW58259.1 - 0.015 15.3 0.1 0.075 13.1 0.0 2.2 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain PAP_RNA-bind PF04926.15 CDW58259.1 - 2.2 7.9 8.2 4.3 6.9 2.3 2.7 2 0 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain HLH PF00010.26 CDW58260.1 - 1.4e-17 63.3 0.2 2.3e-17 62.7 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain BAR PF03114.18 CDW58261.1 - 3.6e-67 226.5 5.9 4.4e-67 226.2 5.9 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 CDW58261.1 - 1.5e-13 50.5 9.0 2e-11 43.6 2.4 2.1 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking SH3_1 PF00018.28 CDW58261.1 - 1.7e-13 50.0 0.0 3.2e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CDW58261.1 - 2.3e-13 49.8 0.0 4.4e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CDW58261.1 - 1.9e-11 43.5 0.0 3.2e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 CDW58261.1 - 0.00053 19.8 5.5 0.0017 18.1 5.1 2.0 1 1 0 1 1 1 1 BAR domain of APPL family NPV_P10 PF05531.12 CDW58261.1 - 0.34 11.4 4.2 2.3 8.7 1.1 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein UDG PF03167.19 CDW58262.1 - 1.9e-18 66.9 0.0 3.4e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily zf-C3HC4_2 PF13923.6 CDW58264.1 - 3.1e-09 36.5 9.5 5.6e-09 35.7 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW58264.1 - 4.8e-08 32.7 9.7 4.8e-08 32.7 9.7 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) RAWUL PF16207.5 CDW58264.1 - 1.2e-06 29.1 0.0 3e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_2 PF13639.6 CDW58264.1 - 3e-05 24.2 8.4 6.7e-05 23.1 8.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CDW58264.1 - 6.4e-05 22.9 5.5 0.00016 21.6 5.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW58264.1 - 0.00012 21.9 8.5 0.00012 21.9 8.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW58264.1 - 0.00088 19.2 10.0 0.0057 16.6 10.7 2.1 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_10 PF16685.5 CDW58264.1 - 0.0015 18.7 6.3 0.0015 18.7 6.3 1.7 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 CDW58264.1 - 0.0024 18.1 5.9 0.006 16.8 5.2 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain CpXC PF14353.6 CDW58264.1 - 0.01 15.9 0.3 0.021 14.9 0.3 1.5 1 0 0 1 1 1 0 CpXC protein zf-C3HC4_4 PF15227.6 CDW58264.1 - 0.013 15.7 8.7 0.036 14.2 8.7 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Imm42 PF15593.6 CDW58264.1 - 0.024 15.1 0.3 0.031 14.8 0.3 1.3 1 0 0 1 1 1 0 Immunity protein 42 Prok-RING_4 PF14447.6 CDW58264.1 - 0.07 13.0 8.7 0.16 11.9 8.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DZR PF12773.7 CDW58264.1 - 0.35 10.9 4.5 0.85 9.7 4.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon IBR PF01485.21 CDW58264.1 - 1.1 9.5 8.2 16 5.8 5.9 2.8 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain EF-hand_7 PF13499.6 CDW58266.1 - 6.4e-15 55.4 2.7 2.3e-10 40.8 2.6 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW58266.1 - 4.2e-11 41.6 4.0 0.00077 18.8 0.3 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 CDW58266.1 - 1.1e-09 37.5 4.4 5.1e-05 22.9 0.6 3.7 2 1 1 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 CDW58266.1 - 0.00016 21.0 0.7 0.65 9.6 0.2 2.9 2 0 0 2 2 2 2 EF hand Glycos_trans_3N PF02885.17 CDW58266.1 - 0.033 14.1 0.1 0.091 12.6 0.1 1.8 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain AAA_2 PF07724.14 CDW58266.1 - 0.075 13.1 0.0 1.5 8.9 0.2 2.2 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) EF-hand_8 PF13833.6 CDW58266.1 - 0.18 11.7 12.1 1.8 8.5 3.9 3.7 1 1 2 3 3 3 0 EF-hand domain pair Band_7 PF01145.25 CDW58267.1 - 6.5e-29 101.2 0.7 6.5e-29 101.2 0.7 2.0 1 1 1 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 CDW58267.1 - 4.9e-15 55.3 2.9 4.9e-15 55.3 2.9 2.7 4 0 0 4 4 4 1 C-terminal region of band_7 Band_7_1 PF13421.6 CDW58267.1 - 0.034 13.9 0.1 0.064 13.0 0.1 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family Cas_Cas4 PF01930.17 CDW58267.1 - 0.14 12.3 4.2 0.17 12.0 3.1 1.7 1 1 0 1 1 1 0 Domain of unknown function DUF83 Collagen PF01391.18 CDW58268.1 - 5e-24 83.8 91.3 8.5e-09 35.0 30.7 4.1 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW58268.1 - 9e-11 41.7 0.1 1.3e-10 41.2 0.1 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Pkinase PF00069.25 CDW58270.1 - 1.3e-52 178.8 0.0 2e-52 178.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58270.1 - 8.6e-23 80.9 0.0 1.3e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW58270.1 - 9.9e-05 21.8 0.0 0.00015 21.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW58270.1 - 0.00047 20.2 0.0 0.00078 19.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW58270.1 - 0.001 17.9 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 CDW58270.1 - 0.0054 16.4 0.0 0.0094 15.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 CDW58270.1 - 0.061 12.9 0.8 8.1 6.0 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 LIM_bind PF01803.16 CDW58271.1 - 1.9e-43 148.8 2.1 7e-33 114.1 0.0 2.7 2 1 1 3 3 3 2 LIM-domain binding protein LID PF17916.1 CDW58271.1 - 9.8e-20 69.9 4.3 1.9e-19 68.9 4.3 1.5 1 0 0 1 1 1 1 LIM interaction domain (LID) HSF_DNA-bind PF00447.17 CDW58271.1 - 0.11 13.2 0.3 0.69 10.6 0.2 2.2 2 0 0 2 2 2 0 HSF-type DNA-binding WAP PF00095.21 CDW58272.1 - 1.1e-10 41.7 17.2 6.6e-08 32.8 4.4 2.5 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' FAM91_C PF14648.6 CDW58272.1 - 0.072 11.9 0.7 0.096 11.5 0.7 1.1 1 0 0 1 1 1 0 FAM91 C-terminus Nodulin_late PF07127.11 CDW58272.1 - 0.11 12.9 13.9 0.52 10.7 2.9 2.4 2 0 0 2 2 2 0 Late nodulin protein Squash PF00299.18 CDW58272.1 - 1.3 9.1 14.6 0.26 11.3 5.1 2.7 2 0 0 2 2 2 0 Squash family serine protease inhibitor DUF4482 PF14818.6 CDW58272.1 - 2.1 9.2 6.5 2.5 9.0 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) FLYWCH PF04500.16 CDW58273.1 - 1.6e-11 44.1 2.9 8.8e-11 41.8 3.1 2.2 2 0 0 2 2 2 1 FLYWCH zinc finger domain MULE PF10551.9 CDW58273.1 - 7e-09 36.0 0.0 3e-07 30.7 0.0 2.4 2 0 0 2 2 2 1 MULE transposase domain Ribosomal_S25 PF03297.15 CDW58274.1 - 4.3e-41 139.2 1.9 5.3e-41 138.9 1.9 1.1 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.19 CDW58274.1 - 0.025 14.5 0.3 0.043 13.7 0.1 1.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.19 CDW58274.1 - 0.11 12.8 0.1 0.18 12.0 0.1 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain BioT2 PF15368.6 CDW58274.1 - 0.13 12.2 0.1 0.19 11.7 0.1 1.5 1 1 0 1 1 1 0 Spermatogenesis family BioT2 COPIIcoated_ERV PF07970.12 CDW58275.1 - 2.6e-29 102.7 0.1 4.3e-29 101.9 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CDW58275.1 - 5e-28 97.3 0.6 9e-28 96.5 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) MCM PF00493.23 CDW58276.1 - 4.5e-68 228.7 0.2 3.9e-67 225.6 0.2 2.1 1 1 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CDW58276.1 - 3.5e-18 65.8 0.0 6.9e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_OB PF17207.3 CDW58276.1 - 9.8e-16 57.8 3.1 2.6e-15 56.4 3.1 1.7 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 CDW58276.1 - 3.8e-07 29.7 0.1 1.5e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDW58276.1 - 0.012 15.7 0.0 0.058 13.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDW58276.1 - 0.015 15.2 0.1 0.063 13.1 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIMELESS PF04821.14 CDW58277.1 - 2.3e-43 148.5 6.8 4.6e-43 147.5 6.8 1.6 1 0 0 1 1 1 1 Timeless protein TIMELESS_C PF05029.13 CDW58277.1 - 7.9e-42 144.2 0.0 7.9e-42 144.2 0.0 2.5 3 0 0 3 3 3 1 Timeless protein C terminal region Myb_DNA-binding PF00249.31 CDW58277.1 - 0.0019 18.4 0.2 0.0094 16.1 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF573 PF04504.14 CDW58277.1 - 2 9.1 5.9 0.93 10.2 0.3 3.5 4 0 0 4 4 4 0 Protein of unknown function, DUF573 DNA_pol3_a_NII PF11490.8 CDW58277.1 - 7.5 6.5 7.3 1.2 9.1 0.9 3.1 3 0 0 3 3 3 0 DNA polymerase III polC-type N-terminus II PA28_beta PF02252.18 CDW58278.1 - 2.3e-11 43.6 0.1 4.1e-11 42.7 0.1 1.4 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit Med13_C PF06333.12 CDW58279.1 - 1.4e-28 100.1 0.1 1.6e-28 100.0 0.1 1.0 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain Glyco_hydro_47 PF01532.20 CDW58280.1 - 2.5e-135 451.9 3.2 4.2e-135 451.2 3.2 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 DAP PF15228.6 CDW58281.1 - 1.2e-22 80.9 4.0 1.4e-22 80.7 4.0 1.1 1 0 0 1 1 1 1 Death-associated protein WD40 PF00400.32 CDW58282.1 - 4.2e-30 103.3 13.4 2e-09 37.9 0.4 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat Katanin_con80 PF13925.6 CDW58282.1 - 1.4e-27 96.7 0.2 2.7e-27 95.8 0.2 1.4 1 0 0 1 1 1 1 con80 domain of Katanin ANAPC4_WD40 PF12894.7 CDW58282.1 - 1.9e-10 40.9 0.0 0.016 15.5 0.0 4.0 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CDW58282.1 - 0.032 12.9 0.6 0.18 10.4 0.0 2.3 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Dymeclin PF09742.9 CDW58283.1 - 2.2e-98 330.3 19.5 3.3e-75 253.8 16.6 2.2 1 1 1 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 CDW58283.1 - 0.071 11.2 15.4 0.031 12.4 12.2 1.9 1 1 1 2 2 2 0 High-temperature-induced dauer-formation protein SMC_N PF02463.19 CDW58284.1 - 1.8e-30 106.0 2.4 2.7e-30 105.5 2.4 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CDW58284.1 - 6e-20 71.7 0.1 8.8e-19 67.9 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_13 PF13166.6 CDW58284.1 - 8.8e-06 24.7 22.0 8.8e-06 24.7 22.0 2.8 2 1 1 3 3 3 1 AAA domain GAS PF13851.6 CDW58284.1 - 0.00023 20.6 47.0 0.0033 16.8 7.8 3.3 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding Sec34 PF04136.15 CDW58284.1 - 0.00027 20.8 36.0 0.011 15.6 11.4 5.3 2 1 3 5 5 5 2 Sec34-like family HAUS-augmin3 PF14932.6 CDW58284.1 - 0.00032 20.4 34.9 0.0049 16.5 10.2 2.4 1 1 1 2 2 2 2 HAUS augmin-like complex subunit 3 HMMR_N PF15905.5 CDW58284.1 - 0.00051 19.6 17.1 0.00051 19.6 17.1 2.8 2 1 1 3 3 3 1 Hyaluronan mediated motility receptor N-terminal DUF812 PF05667.11 CDW58284.1 - 0.0023 16.9 36.9 0.023 13.6 36.1 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF812) EcsC PF12787.7 CDW58284.1 - 0.004 16.9 0.0 0.27 10.9 0.0 3.1 1 1 1 2 2 2 1 EcsC protein family Fez1 PF06818.15 CDW58284.1 - 0.004 17.6 39.1 0.21 12.0 0.6 3.6 1 1 2 3 3 3 2 Fez1 CALCOCO1 PF07888.11 CDW58284.1 - 0.0048 15.8 15.3 0.0048 15.8 15.3 2.9 2 1 1 3 3 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like Laminin_I PF06008.14 CDW58284.1 - 0.0056 16.4 8.2 0.0056 16.4 8.2 3.6 2 1 1 3 3 3 1 Laminin Domain I ADIP PF11559.8 CDW58284.1 - 0.011 15.8 3.7 0.011 15.8 3.7 5.1 2 1 4 6 6 6 0 Afadin- and alpha -actinin-Binding ERM PF00769.19 CDW58284.1 - 0.014 15.2 41.7 0.059 13.2 12.1 2.6 2 1 0 2 2 2 0 Ezrin/radixin/moesin family DHR10 PF18595.1 CDW58284.1 - 0.079 13.0 52.8 0.073 13.1 12.9 5.5 2 1 3 5 5 5 0 Designed helical repeat protein 10 domain NAS PF03059.16 CDW58284.1 - 0.079 12.3 4.4 1.3 8.3 0.0 3.5 3 1 0 3 3 3 0 Nicotianamine synthase protein APG6_N PF17675.1 CDW58284.1 - 0.12 13.0 54.5 0.75 10.3 17.4 4.8 2 2 1 3 3 3 0 Apg6 coiled-coil region Tropomyosin PF00261.20 CDW58284.1 - 0.17 11.2 49.5 0.13 11.6 19.6 4.3 2 1 2 4 4 4 0 Tropomyosin DUF3584 PF12128.8 CDW58284.1 - 0.2 9.1 42.7 0.81 7.1 42.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Spectrin PF00435.21 CDW58284.1 - 0.36 11.3 32.0 0.25 11.9 9.4 4.3 1 1 1 3 3 3 0 Spectrin repeat Exonuc_VII_L PF02601.15 CDW58284.1 - 0.46 10.0 38.0 0.025 14.2 14.8 3.1 1 1 1 3 3 3 0 Exonuclease VII, large subunit CENP-F_leu_zip PF10473.9 CDW58284.1 - 0.52 10.3 50.4 0.22 11.6 14.8 3.8 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fib_alpha PF08702.10 CDW58284.1 - 0.58 10.3 37.0 0.072 13.3 7.1 4.5 2 1 2 4 4 3 0 Fibrinogen alpha/beta chain family Filament PF00038.21 CDW58284.1 - 0.6 9.6 44.5 0.69 9.4 31.9 3.5 2 1 1 3 3 3 0 Intermediate filament protein CLZ PF16526.5 CDW58284.1 - 0.62 10.5 29.2 0.59 10.5 2.0 5.2 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ATG16 PF08614.11 CDW58284.1 - 0.64 10.2 50.7 0.025 14.8 12.9 4.3 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) FPP PF05911.11 CDW58284.1 - 0.72 8.0 40.9 0.55 8.4 38.3 2.1 1 1 0 2 2 2 0 Filament-like plant protein, long coiled-coil CorA PF01544.18 CDW58284.1 - 0.96 8.7 29.3 0.1 11.9 5.2 4.0 2 1 2 4 4 4 0 CorA-like Mg2+ transporter protein EzrA PF06160.12 CDW58284.1 - 1.3 7.1 44.9 0.36 9.0 1.9 3.5 2 1 2 4 4 4 0 Septation ring formation regulator, EzrA Laminin_II PF06009.12 CDW58284.1 - 1.4 8.9 38.0 0.41 10.6 1.4 5.1 2 1 2 5 5 5 0 Laminin Domain II ATP-synt_DE PF00401.20 CDW58284.1 - 1.9 8.8 7.5 16 5.8 0.5 3.8 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Golgin_A5 PF09787.9 CDW58284.1 - 2.1 7.7 48.8 0.15 11.5 27.5 2.6 1 1 1 2 2 2 0 Golgin subfamily A member 5 Syntaxin-6_N PF09177.11 CDW58284.1 - 2.1 8.9 33.5 0.27 11.8 5.0 5.1 2 1 2 4 4 3 0 Syntaxin 6, N-terminal Tektin PF03148.14 CDW58284.1 - 2.3 6.9 39.6 1.1 8.0 24.7 3.3 1 1 2 3 3 3 0 Tektin family Spc7 PF08317.11 CDW58284.1 - 2.5 6.9 50.3 0.0056 15.6 13.4 3.8 2 1 1 3 3 3 0 Spc7 kinetochore protein She9_MDM33 PF05546.11 CDW58284.1 - 3 7.6 25.5 5.3 6.8 4.3 2.7 1 1 0 2 2 2 0 She9 / Mdm33 family DUF948 PF06103.11 CDW58284.1 - 3.1 8.1 23.6 1.2 9.4 0.4 5.5 2 1 3 5 5 4 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 CDW58284.1 - 3.5 6.9 32.9 3.4 7.0 8.5 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) MCPsignal PF00015.21 CDW58284.1 - 3.9 7.3 15.3 0.17 11.7 0.6 3.5 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain HOOK PF05622.12 CDW58284.1 - 4.2 5.4 47.4 0.89 7.6 42.1 2.4 2 1 0 2 2 2 0 HOOK protein DUF5446 PF17522.2 CDW58284.1 - 4.6 7.5 29.2 2.4 8.4 1.8 5.5 2 1 4 6 6 5 0 Family of unknown function (DUF5446) Med21 PF11221.8 CDW58284.1 - 6.1 7.1 33.9 1.3 9.2 10.1 4.0 2 1 1 3 3 3 0 Subunit 21 of Mediator complex Seryl_tRNA_N PF02403.22 CDW58284.1 - 7.4 6.9 39.0 0.3 11.3 5.2 5.2 2 1 3 5 5 5 0 Seryl-tRNA synthetase N-terminal domain T3SSipB PF16535.5 CDW58284.1 - 9 6.8 27.1 0.2 12.1 3.2 4.1 1 1 2 3 3 2 0 Type III cell invasion protein SipB NDUF_B12 PF08122.12 CDW58285.1 - 0.096 12.7 0.1 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF4728 PF15860.5 CDW58285.1 - 1.5 9.5 14.3 0.089 13.5 7.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4728) zf-Tim10_DDP PF02953.15 CDW58286.1 - 4.1e-22 77.6 0.3 4.1e-22 77.6 0.3 1.7 2 0 0 2 2 2 1 Tim10/DDP family zinc finger DUF505 PF04458.12 CDW58286.1 - 0.033 12.6 0.1 0.033 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) NCD3G PF07562.14 CDW58286.1 - 0.054 13.5 0.7 0.086 12.8 0.7 1.4 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR Peptidase_C26 PF07722.13 CDW58287.1 - 7.9e-11 42.1 0.0 1.2e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 GATase PF00117.28 CDW58287.1 - 3.2e-06 27.1 0.0 4.7e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Squash PF00299.18 CDW58287.1 - 0.025 14.6 0.4 0.025 14.6 0.4 2.5 2 0 0 2 2 2 0 Squash family serine protease inhibitor CENP-X PF09415.10 CDW58287.1 - 0.091 13.1 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X SNO PF01174.19 CDW58287.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Msap1 PF17077.5 CDW58288.1 - 0.14 11.3 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 MEIOC PF15189.6 CDW58289.1 - 4.2e-31 107.8 0.1 7.1e-31 107.1 0.1 1.2 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC MEIOC PF15189.6 CDW58290.1 - 3.5e-16 59.3 0.2 4.3e-16 59.0 0.2 1.1 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC REV1_C PF16727.5 CDW58290.1 - 0.033 14.6 0.0 0.044 14.2 0.0 1.2 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain APG6_N PF17675.1 CDW58291.1 - 0.017 15.7 8.6 0.017 15.7 8.6 5.7 2 1 4 6 6 6 0 Apg6 coiled-coil region NPV_P10 PF05531.12 CDW58291.1 - 2.6 8.5 11.3 2.3 8.7 0.4 5.2 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein I-set PF07679.16 CDW58292.1 - 1.2e-66 220.8 0.0 1.4e-19 69.9 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW58292.1 - 4.6e-60 200.2 1.1 1.1e-15 57.9 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain ig PF00047.25 CDW58292.1 - 5e-40 135.6 0.3 7.9e-11 42.0 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 CDW58292.1 - 6.7e-40 135.3 0.1 1.9e-11 44.2 0.0 5.6 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 CDW58292.1 - 2.5e-26 92.0 8.1 6.4e-07 29.5 0.0 8.2 5 3 1 7 7 7 5 Immunoglobulin V-set domain fn3 PF00041.21 CDW58292.1 - 9.8e-17 61.1 0.7 3.6e-10 40.1 0.0 3.2 3 0 0 3 3 3 2 Fibronectin type III domain Ig_6 PF18452.1 CDW58292.1 - 1.3e-10 40.7 6.5 0.036 13.6 0.0 6.3 8 0 0 8 8 7 3 Immunoglobulin domain C2-set_2 PF08205.12 CDW58292.1 - 1.9e-08 34.2 0.2 0.38 10.8 0.1 4.7 5 0 0 5 5 4 2 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 CDW58292.1 - 2.3e-08 34.0 1.5 1.2 9.2 0.0 6.0 6 1 0 6 6 6 2 Izumo-like Immunoglobulin domain Ig_5 PF16681.5 CDW58292.1 - 1.9e-07 31.4 2.7 1.1 9.7 0.0 6.2 5 2 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 CDW58292.1 - 3.3e-07 30.5 1.0 3.3 8.1 0.0 6.1 5 2 1 6 6 6 1 T-cell surface glycoprotein CD3 delta chain Pur_ac_phosph_N PF16656.5 CDW58292.1 - 2.3e-06 28.1 0.5 0.1 13.2 0.1 3.3 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain Ig_C17orf99 PF17736.1 CDW58292.1 - 2.8e-06 27.3 0.1 0.76 9.9 0.0 5.0 6 0 0 6 6 5 2 C17orf99 Ig domain DUF4731 PF15875.5 CDW58292.1 - 0.0024 18.0 0.7 0.0057 16.8 0.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4731) Big_10 PF17964.1 CDW58292.1 - 0.019 14.9 0.1 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Bacterial Ig domain DUF4690 PF15756.5 CDW58292.1 - 0.052 14.2 0.0 0.18 12.4 0.0 1.9 1 0 0 1 1 1 0 Small Novel Rich in Cartilage PhoD_N PF16655.5 CDW58292.1 - 0.14 12.7 0.0 3.2 8.3 0.0 2.9 3 0 0 3 3 3 0 PhoD-like phosphatase, N-terminal domain FANCI_S4 PF14678.6 CDW58293.1 - 6.5e-53 179.4 0.2 1e-52 178.8 0.2 1.3 1 0 0 1 1 1 1 FANCI solenoid 4 FANCI_S3 PF14677.6 CDW58293.1 - 1.3e-06 28.3 1.2 3.4e-06 26.9 0.1 2.0 2 0 0 2 2 2 1 FANCI solenoid 3 DUF416 PF04222.12 CDW58295.1 - 0.076 12.4 1.6 0.12 11.8 0.6 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF416) Ribosomal_S17e PF00833.18 CDW58295.1 - 0.091 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal S17 Bromodomain PF00439.25 CDW58296.1 - 9.2e-101 330.1 15.3 1.2e-18 66.9 0.4 6.8 6 0 0 6 6 6 6 Bromodomain BAH PF01426.18 CDW58296.1 - 2e-20 72.9 0.0 7.8e-10 38.7 0.0 2.5 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.19 CDW58296.1 - 1.5e-15 57.4 3.2 2.1e-15 56.9 0.4 2.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW58296.1 - 4.3e-09 36.8 0.2 1.5e-08 35.1 0.2 1.9 1 0 0 1 1 1 1 HMG-box domain zf-C2H2_aberr PF17017.5 CDW58296.1 - 0.092 12.9 1.6 0.24 11.5 1.6 1.7 1 0 0 1 1 1 0 Aberrant zinc-finger FOXP-CC PF16159.5 CDW58296.1 - 0.3 11.8 5.7 0.31 11.7 1.0 2.8 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 CDW58296.1 - 1.6 9.4 6.5 5.3 7.7 1.6 3.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW58296.1 - 7.3 7.7 6.0 1e+02 4.1 1.6 3.3 2 0 0 2 2 2 0 C2H2-type zinc finger BAF PF02961.14 CDW58297.1 - 6.9e-32 109.7 0.0 8.5e-32 109.5 0.0 1.0 1 0 0 1 1 1 1 Barrier to autointegration factor IMS_HHH PF11798.8 CDW58297.1 - 0.045 14.1 0.0 0.96 9.9 0.0 2.2 2 0 0 2 2 2 0 IMS family HHH motif HHH_5 PF14520.6 CDW58297.1 - 0.15 12.7 0.0 0.23 12.1 0.0 1.5 1 1 0 1 1 1 0 Helix-hairpin-helix domain DUF4365 PF14280.6 CDW58298.1 - 0.021 14.8 0.1 0.052 13.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4365) VWD PF00094.25 CDW58299.1 - 0.023 15.0 0.3 7.2 6.9 0.0 3.0 3 1 0 4 4 4 0 von Willebrand factor type D domain XRCC1_N PF01834.16 CDW58301.1 - 9.5e-35 119.8 0.4 2.8e-34 118.3 0.0 1.9 2 0 0 2 2 2 1 XRCC1 N terminal domain BRCT PF00533.26 CDW58301.1 - 1.4e-09 38.2 0.0 3.2e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CDW58301.1 - 2.9e-09 36.7 0.0 5.7e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 CDW58301.1 - 5e-05 23.6 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF4810 PF16068.5 CDW58301.1 - 0.091 13.3 0.0 0.32 11.6 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4810) Ras PF00071.22 CDW58302.1 - 3.4e-34 117.8 0.2 4.4e-34 117.4 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW58302.1 - 2.7e-14 53.4 0.0 4.5e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 CDW58302.1 - 4.4e-08 32.9 0.1 5.4e-07 29.3 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CDW58302.1 - 7.3e-08 32.1 0.0 9.7e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW58302.1 - 1e-06 28.8 0.0 1.5e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW58302.1 - 0.0032 17.4 0.1 0.058 13.3 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CDW58302.1 - 0.014 15.6 0.3 2.3 8.5 0.0 2.9 2 1 0 2 2 2 0 AAA domain G-alpha PF00503.20 CDW58302.1 - 0.026 13.7 0.1 5.5 6.0 0.0 2.3 2 1 0 2 2 2 0 G-protein alpha subunit DUF249 PF03158.13 CDW58302.1 - 0.028 14.1 0.3 0.082 12.6 0.1 1.7 1 1 1 2 2 2 0 Multigene family 530 protein SRPRB PF09439.10 CDW58302.1 - 0.087 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit EF-hand_1 PF00036.32 CDW58303.1 - 2.3e-40 133.1 16.2 1.3e-10 40.0 0.9 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CDW58303.1 - 2.1e-33 114.6 11.9 3.3e-14 53.1 4.2 2.9 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 CDW58303.1 - 3.2e-29 98.3 7.1 5.2e-09 35.3 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 CDW58303.1 - 1.3e-27 95.4 16.3 7.6e-13 48.1 3.3 4.3 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 CDW58303.1 - 1.1e-22 78.5 7.9 1.1e-05 24.6 0.5 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CDW58303.1 - 8.3e-13 48.5 0.6 6.8e-06 26.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CDW58303.1 - 1.6e-09 37.7 3.7 0.00036 20.4 0.1 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CDW58303.1 - 8.7e-07 29.3 0.9 0.018 15.4 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 CDW58303.1 - 5.5e-06 27.2 0.2 0.011 16.6 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain EFhand_Ca_insen PF08726.10 CDW58303.1 - 0.00076 19.5 4.3 0.0093 16.0 2.5 2.4 2 0 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 CDW58303.1 - 0.0012 18.9 1.4 0.16 12.2 0.6 3.2 1 1 2 3 3 3 1 Dockerin type I domain Caleosin PF05042.13 CDW58303.1 - 0.0014 18.6 0.8 1.6 8.6 0.0 3.2 1 1 1 3 3 3 1 Caleosin related protein UPF0154 PF03672.13 CDW58303.1 - 0.0027 17.7 7.7 0.15 12.1 0.1 3.2 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) TerB PF05099.13 CDW58303.1 - 0.0032 17.4 1.3 0.54 10.2 0.2 2.5 1 1 1 2 2 2 1 Tellurite resistance protein TerB DUF3349 PF11829.8 CDW58303.1 - 0.0048 17.6 0.3 1.3 9.8 0.0 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF3349) Toprim_2 PF13155.6 CDW58303.1 - 0.0049 17.3 0.1 0.39 11.2 0.0 2.3 1 1 1 2 2 2 1 Toprim-like DUF3016 PF11454.8 CDW58303.1 - 0.048 13.4 0.2 0.062 13.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3016) Phage_TAC_12 PF12363.8 CDW58303.1 - 0.065 13.7 0.5 0.62 10.5 0.1 2.3 1 1 1 2 2 2 0 Phage tail assembly chaperone protein, TAC FGAR-AT_linker PF18072.1 CDW58303.1 - 0.2 12.2 0.5 2.1 9.0 0.0 2.5 3 0 0 3 3 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain Imm1 PF14430.6 CDW58303.1 - 0.36 11.5 1.4 31 5.2 0.0 2.8 1 1 1 2 2 2 0 Immunity protein Imm1 SurA_N_2 PF13623.6 CDW58303.1 - 0.49 10.3 5.3 1.1 9.1 0.8 2.6 1 1 1 2 2 2 0 SurA N-terminal domain TM231 PF10149.9 CDW58304.1 - 1.2e-50 172.6 7.7 1.4e-50 172.4 7.7 1.0 1 0 0 1 1 1 1 Transmembrane protein 231 Ribosomal_L37 PF08561.10 CDW58305.1 - 6.2e-06 26.7 0.8 1.2e-05 25.8 0.8 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L37 UPF0182 PF03699.13 CDW58305.1 - 0.33 9.0 2.4 0.43 8.7 2.4 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) MIG-14_Wnt-bd PF06664.12 CDW58306.1 - 0.021 14.1 0.1 0.025 13.8 0.1 1.0 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Ninjurin PF04923.12 CDW58306.1 - 0.06 13.3 0.4 0.067 13.1 0.4 1.1 1 0 0 1 1 1 0 Ninjurin HEAT PF02985.22 CDW58307.1 - 6e-09 35.4 9.4 0.097 13.0 0.1 6.5 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 CDW58307.1 - 1.6e-07 31.6 2.1 0.074 13.4 0.4 4.9 3 1 2 5 5 5 2 HEAT repeats CLASP_N PF12348.8 CDW58307.1 - 2e-06 27.6 0.4 0.017 14.7 0.1 2.2 2 0 0 2 2 2 2 CLASP N terminal HEAT_EZ PF13513.6 CDW58307.1 - 1.7e-05 25.2 1.3 0.033 14.7 0.5 3.3 3 0 0 3 3 3 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CDW58307.1 - 0.053 14.1 2.1 8.9 7.0 0.0 3.8 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region TAN PF11640.8 CDW58307.1 - 0.097 12.8 0.0 0.6 10.2 0.0 2.3 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair RNA_pol PF00940.19 CDW58308.1 - 8.4e-157 522.3 0.0 1.3e-156 521.6 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CDW58308.1 - 8.7e-26 91.1 0.0 1.7e-25 90.2 0.0 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal ATP_sub_h PF10775.9 CDW58308.1 - 0.3 11.1 0.9 0.73 9.9 0.9 1.6 1 0 0 1 1 1 0 ATP synthase complex subunit h Linker_histone PF00538.19 CDW58310.1 - 1.1e-26 92.9 0.3 1.1e-26 92.9 0.3 1.8 2 0 0 2 2 2 1 linker histone H1 and H5 family NARG2_C PF10505.9 CDW58311.1 - 2.1e-24 86.2 0.0 3.2e-24 85.6 0.0 1.2 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus DEAD PF00270.29 CDW58312.1 - 4.4e-45 153.6 0.0 7e-45 152.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW58312.1 - 2e-27 95.8 0.1 9.4e-27 93.6 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW58312.1 - 2.7e-05 24.2 0.0 6.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ResIII PF04851.15 CDW58313.1 - 7.9e-14 52.0 0.0 1.7e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDW58313.1 - 9.4e-14 51.7 0.1 3e-12 46.9 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Dicer_dimer PF03368.14 CDW58313.1 - 2.3e-13 50.1 0.0 4.9e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Dicer dimerisation domain DEAD PF00270.29 CDW58313.1 - 3.1e-11 43.3 0.0 6.1e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CDW58313.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_26 PF13500.6 CDW58313.1 - 0.072 12.9 0.5 0.51 10.1 0.1 2.3 1 1 0 2 2 2 0 AAA domain dsrm PF00035.26 CDW58313.1 - 0.11 13.3 0.0 0.31 11.8 0.0 1.9 1 0 0 1 1 1 0 Double-stranded RNA binding motif ubiquitin PF00240.23 CDW58314.1 - 3.3e-10 39.6 0.0 6.1e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family BAG PF02179.16 CDW58314.1 - 6e-06 26.6 1.0 1.2e-05 25.6 1.0 1.6 1 0 0 1 1 1 1 BAG domain Ubiquitin_5 PF18037.1 CDW58314.1 - 0.0026 18.1 0.0 0.007 16.7 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 CDW58314.1 - 0.082 13.5 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain HTH_25 PF13413.6 CDW58314.1 - 0.17 11.8 3.6 0.27 11.1 1.8 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain NOC3p PF07540.11 CDW58315.1 - 9.4e-27 93.3 0.3 5.9e-26 90.8 0.1 2.5 2 0 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 CDW58315.1 - 1.1e-07 32.1 0.3 3.3e-07 30.5 0.3 2.0 1 1 0 1 1 1 1 CBF/Mak21 family HEAT_EZ PF13513.6 CDW58315.1 - 0.0062 17.0 0.0 3.4 8.3 0.0 2.9 2 0 0 2 2 2 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CDW58315.1 - 0.055 14.1 0.0 0.3 11.7 0.0 2.3 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region PWWP PF00855.17 CDW58316.1 - 2e-10 40.9 0.3 1.1e-09 38.6 0.3 2.1 1 1 0 1 1 1 1 PWWP domain Zona_pellucida PF00100.23 CDW58317.1 - 1.2e-06 28.6 0.5 1.5e-06 28.3 0.5 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain DUF4508 PF14969.6 CDW58317.1 - 0.11 12.8 0.1 0.16 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) UDPGT PF00201.18 CDW58318.1 - 2.9e-40 138.5 1.6 1.9e-39 135.8 1.6 1.9 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CDW58318.1 - 3.4e-09 36.9 0.0 6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain APOBEC_N PF08210.11 CDW58319.1 - 0.16 11.8 0.6 0.29 11.0 0.6 1.4 1 1 0 1 1 1 0 APOBEC-like N-terminal domain AT_hook PF02178.19 CDW58320.1 - 0.3 11.1 45.4 0.079 12.9 5.9 5.2 5 0 0 5 5 5 0 AT hook motif Ras PF00071.22 CDW58321.1 - 8.3e-16 58.0 0.0 1.1e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW58321.1 - 2.3e-15 56.9 0.0 3.5e-15 56.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW58321.1 - 7.9e-10 38.5 0.0 1.2e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 CDW58321.1 - 0.0012 18.6 0.0 0.004 16.9 0.0 1.7 1 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDW58321.1 - 0.0028 17.7 0.0 0.004 17.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CDW58321.1 - 0.0076 15.7 0.0 0.013 14.9 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CDW58321.1 - 0.011 14.9 0.3 0.7 9.0 0.0 2.2 1 1 1 2 2 2 0 G-protein alpha subunit IIGP PF05049.13 CDW58321.1 - 0.023 13.8 0.0 0.031 13.4 0.0 1.4 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.27 CDW58321.1 - 0.039 13.5 0.0 0.17 11.4 0.0 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Septin PF00735.18 CDW58321.1 - 0.054 12.8 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 Septin Dynamin_N PF00350.23 CDW58321.1 - 0.097 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Dynamin family NIF PF03031.18 CDW58322.1 - 3e-50 170.0 0.0 3.9e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Fucose_iso_C PF02952.17 CDW58322.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain Carn_acyltransf PF00755.20 CDW58323.1 - 1.2e-187 625.2 0.0 1.5e-187 624.9 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.5 CDW58323.1 - 2.3e-21 75.5 0.0 6.5e-21 74.1 0.0 1.8 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus Voltage_CLC PF00654.20 CDW58324.1 - 2.2e-66 224.6 33.7 8.2e-42 143.7 7.9 2.6 1 1 2 3 3 3 2 Voltage gated chloride channel CBS PF00571.28 CDW58324.1 - 5.1e-06 26.8 0.2 0.048 14.1 0.2 2.7 2 0 0 2 2 2 2 CBS domain Stevor PF17410.2 CDW58325.1 - 0.00018 21.1 0.1 45 3.4 0.0 4.8 5 0 0 5 5 5 0 Subtelomeric Variable Open Reading frame DUF3926 PF13080.6 CDW58325.1 - 0.03 14.3 0.0 1.7e+02 2.2 0.0 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF3926) ETF_alpha PF00766.19 CDW58325.1 - 0.7 9.9 5.6 74 3.5 0.0 3.8 5 0 0 5 5 5 0 Electron transfer flavoprotein FAD-binding domain DX PF01666.17 CDW58325.1 - 2.6 8.6 9.2 56 4.3 0.3 3.4 3 0 0 3 3 3 0 DX module Ets PF00178.22 CDW58326.1 - 3.6e-36 123.5 0.2 5.6e-36 122.9 0.2 1.3 1 0 0 1 1 1 1 Ets-domain CAF1C_H4-bd PF12265.8 CDW58328.1 - 7.3e-24 83.8 2.5 7.3e-23 80.6 0.8 2.6 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CDW58328.1 - 4e-22 78.1 16.3 0.00014 22.6 0.4 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW58328.1 - 0.0062 16.8 0.2 26 5.2 0.0 3.5 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 CDW58329.1 - 0.0021 18.0 0.8 1.7 8.9 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDW58329.1 - 0.054 13.7 1.0 12 6.4 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4886 PF16227.5 CDW58329.1 - 0.071 12.3 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) TPR_1 PF00515.28 CDW58329.1 - 0.077 12.8 0.8 6 6.9 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat SARAF PF06682.12 CDW58330.1 - 0.0019 17.9 0.1 0.0025 17.5 0.1 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 CDW58330.1 - 0.023 15.5 0.6 0.045 14.6 0.6 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ECM1 PF05782.11 CDW58330.1 - 0.051 12.5 0.2 0.059 12.3 0.2 1.0 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) DUF4834 PF16118.5 CDW58330.1 - 0.28 12.2 3.2 1.6 9.7 3.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) CRA PF06589.11 CDW58330.1 - 0.28 11.3 3.1 0.63 10.2 3.1 1.6 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) FAM176 PF14851.6 CDW58330.1 - 0.63 9.7 7.3 13 5.4 7.3 2.0 1 1 0 1 1 1 0 FAM176 family MAP17 PF15807.5 CDW58330.1 - 3 8.1 4.8 16 5.7 4.8 1.9 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 NPR3 PF03666.13 CDW58330.1 - 3.5 6.3 9.6 4.1 6.1 9.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TMIE PF16038.5 CDW58330.1 - 4.1 7.3 5.9 5.5 6.9 5.9 1.4 1 1 0 1 1 1 0 TMIE protein Ldl_recept_a PF00057.18 CDW58331.1 - 1.4e-09 38.0 6.5 1.4e-09 38.0 6.5 2.0 2 1 0 2 2 2 1 Low-density lipoprotein receptor domain class A NPC1_N PF16414.5 CDW58332.1 - 1.4e-45 155.8 10.5 1.7e-45 155.5 10.5 1.0 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Folate_rec PF03024.14 CDW58332.1 - 0.025 14.4 10.3 0.042 13.7 10.3 1.5 1 1 0 1 1 1 0 Folate receptor family Trypsin PF00089.26 CDW58333.1 - 4.9e-58 196.5 0.1 7.7e-58 195.9 0.1 1.3 1 0 0 1 1 1 1 Trypsin PAN_1 PF00024.26 CDW58333.1 - 1.1e-05 25.3 1.3 2.8e-05 24.0 1.3 1.8 1 0 0 1 1 1 1 PAN domain WBP-1 PF11669.8 CDW58333.1 - 0.00011 22.8 0.2 0.00011 22.8 0.2 2.0 2 0 0 2 2 2 1 WW domain-binding protein 1 Trypsin_2 PF13365.6 CDW58333.1 - 0.00061 20.7 0.0 0.0066 17.4 0.0 2.2 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW58333.1 - 0.029 14.7 0.0 0.061 13.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) TMEM154 PF15102.6 CDW58333.1 - 0.059 13.3 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family GAPT PF11770.8 CDW58333.1 - 0.16 11.9 0.1 0.38 10.6 0.1 1.6 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) TMEM52 PF14979.6 CDW58333.1 - 0.36 10.7 6.0 0.63 9.9 4.7 2.0 2 0 0 2 2 2 0 Transmembrane 52 LIM PF00412.22 CDW58334.1 - 2.3e-27 95.0 23.2 1.7e-15 56.9 6.9 2.3 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 CDW58334.1 - 2.2e-19 69.0 1.5 4.3e-19 68.1 1.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW58334.1 - 0.002 18.0 0.0 0.0056 16.5 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain HypA PF01155.19 CDW58334.1 - 0.013 15.5 0.8 0.013 15.5 0.8 2.8 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Arc_trans_TRASH PF08394.10 CDW58334.1 - 0.019 15.3 1.4 0.019 15.3 1.4 2.3 2 0 0 2 2 2 0 Archaeal TRASH domain NinD PF17466.2 CDW58334.1 - 0.13 12.3 0.2 0.13 12.3 0.2 2.5 2 0 0 2 2 2 0 Family of unknown function RabGAP-TBC PF00566.18 CDW58335.1 - 5.6e-29 101.3 1.7 5.8e-26 91.5 0.5 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Q_salvage PF10343.9 CDW58336.1 - 6.2e-94 314.7 0.0 7.1e-94 314.5 0.0 1.0 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 CDW58336.1 - 0.16 10.7 0.0 0.41 9.3 0.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1688) TUDOR PF00567.24 CDW58337.1 - 4.9e-19 68.5 0.0 8.6e-10 38.7 0.0 2.2 2 0 0 2 2 2 2 Tudor domain SMN PF06003.12 CDW58337.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) CarbpepA_inh PF02977.15 CDW58338.1 - 0.00049 19.8 22.1 0.0098 15.7 5.1 2.5 2 1 0 2 2 2 2 Carboxypeptidase A inhibitor Dickkopf_N PF04706.12 CDW58338.1 - 0.0068 16.9 30.8 0.78 10.3 10.8 3.7 3 1 1 4 4 4 4 Dickkopf N-terminal cysteine-rich region EB PF01683.18 CDW58338.1 - 0.031 14.6 32.2 0.069 13.5 5.8 4.1 1 1 3 4 4 4 0 EB module ARL6IP6 PF15062.6 CDW58338.1 - 0.054 13.6 0.0 0.093 12.9 0.0 1.3 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix E1_DerP2_DerF2 PF02221.15 CDW58339.1 - 7.4e-08 32.9 0.3 1.1e-07 32.3 0.3 1.3 1 1 0 1 1 1 1 ML domain E1_DerP2_DerF2 PF02221.15 CDW58340.1 - 8.2e-14 52.2 0.3 9.8e-14 51.9 0.3 1.1 1 0 0 1 1 1 1 ML domain Chordopox_A13L PF05961.11 CDW58341.1 - 0.0046 17.2 0.3 0.0055 16.9 0.3 1.1 1 0 0 1 1 1 1 Chordopoxvirus A13L protein TNFR_16_TM PF18422.1 CDW58341.1 - 0.011 15.6 2.8 0.011 15.6 2.8 1.5 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain Syndecan PF01034.20 CDW58341.1 - 0.068 13.1 3.8 0.12 12.4 3.8 1.4 1 1 0 1 1 1 0 Syndecan domain Vpu PF00558.19 CDW58341.1 - 0.17 11.6 0.1 0.2 11.4 0.1 1.1 1 0 0 1 1 1 0 Vpu protein PARM PF17061.5 CDW58341.1 - 0.32 11.1 1.7 0.39 10.8 1.7 1.0 1 0 0 1 1 1 0 PARM Methyltransf_11 PF08241.12 CDW58342.1 - 6.4e-18 65.2 0.1 1.1e-17 64.5 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW58342.1 - 1.9e-13 50.9 0.1 4.2e-13 49.8 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW58342.1 - 2.6e-13 50.2 0.0 6.5e-13 48.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW58342.1 - 9.9e-13 48.7 0.1 1.5e-12 48.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW58342.1 - 1.2e-12 47.9 0.0 1.7e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 CDW58342.1 - 1.5e-08 34.5 0.0 1.9e-08 34.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 CDW58342.1 - 8.1e-08 32.0 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 CDW58342.1 - 1.1e-06 28.2 0.1 1.5e-06 27.7 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 CDW58342.1 - 0.0008 19.0 0.1 0.0016 18.0 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 CDW58342.1 - 0.0013 18.7 0.0 0.002 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CDW58342.1 - 0.019 14.6 0.0 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DUF1175 PF06672.11 CDW58342.1 - 0.053 13.2 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1175) AdoMet_MTase PF07757.13 CDW58342.1 - 0.056 13.8 0.1 0.13 12.6 0.1 1.6 1 1 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase ADH_zinc_N PF00107.26 CDW58342.1 - 0.077 13.0 0.2 0.18 11.8 0.2 1.6 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Complex1_LYR PF05347.15 CDW58343.1 - 0.0015 18.5 0.4 0.0036 17.3 0.4 1.7 1 1 0 1 1 1 1 Complex 1 protein (LYR family) CCDC53 PF10152.9 CDW58344.1 - 0.0065 16.9 0.7 0.0075 16.7 0.7 1.2 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex MtrG PF04210.13 CDW58344.1 - 0.038 13.8 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G HSBP1 PF06825.12 CDW58344.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Ribosomal_L1 PF00687.21 CDW58345.1 - 3.8e-37 128.0 3.4 4.2e-37 127.9 1.8 1.8 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family ThiF PF00899.21 CDW58345.1 - 3.8e-21 75.6 0.0 1.1e-17 64.2 0.0 2.3 2 0 0 2 2 2 2 ThiF family zf-C4 PF00105.18 CDW58347.1 - 8.1e-31 106.3 18.9 1.7e-30 105.3 18.9 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 CDW58347.1 - 8.9e-09 35.2 0.1 0.0003 20.4 0.0 2.2 1 1 1 2 2 2 2 Ligand-binding domain of nuclear hormone receptor Herpes_UL33 PF03581.13 CDW58347.1 - 0.053 13.9 0.2 0.15 12.5 0.2 1.8 1 0 0 1 1 1 0 Herpesvirus UL33-like protein DUF3453 PF11935.8 CDW58347.1 - 0.094 12.3 0.7 0.19 11.3 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3453) S_locus_glycop PF00954.20 CDW58347.1 - 0.98 10.0 8.1 1.9 9.1 3.8 2.4 2 0 0 2 2 2 0 S-locus glycoprotein domain AAA PF00004.29 CDW58348.1 - 9e-40 136.2 0.5 4.5e-26 91.8 0.0 2.9 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW58348.1 - 8.8e-11 41.4 0.1 1.9e-10 40.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDW58348.1 - 2.2e-08 33.9 1.2 5.3e-08 32.7 1.2 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CDW58348.1 - 3e-07 30.5 0.0 1.9e-06 28.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW58348.1 - 9.3e-06 26.1 0.1 0.00013 22.4 0.1 2.5 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.12 CDW58348.1 - 8.1e-05 22.4 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CDW58348.1 - 0.00023 21.3 0.0 0.001 19.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 CDW58348.1 - 0.00028 21.4 1.3 0.013 16.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain TIP49 PF06068.13 CDW58348.1 - 0.0012 18.1 0.6 0.0029 16.9 0.0 1.9 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 CDW58348.1 - 0.0031 17.8 1.3 0.03 14.6 0.1 2.9 3 1 0 4 4 3 1 AAA domain AAA_33 PF13671.6 CDW58348.1 - 0.0034 17.5 0.0 0.0072 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CDW58348.1 - 0.0043 16.8 0.0 0.0094 15.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDW58348.1 - 0.0057 16.1 0.1 0.016 14.6 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DivIC PF04977.15 CDW58348.1 - 0.0058 16.4 0.8 0.014 15.2 0.8 1.6 1 0 0 1 1 1 1 Septum formation initiator ATPase PF06745.13 CDW58348.1 - 0.0072 15.7 0.1 0.033 13.5 0.0 2.1 2 0 0 2 2 2 1 KaiC AAA_3 PF07726.11 CDW58348.1 - 0.022 14.6 0.0 0.06 13.2 0.0 1.8 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CDW58348.1 - 0.024 15.0 0.0 0.047 14.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 CDW58348.1 - 0.025 14.3 0.2 0.11 12.1 0.0 2.1 2 1 1 3 3 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 CDW58348.1 - 0.026 14.2 0.0 0.072 12.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDW58348.1 - 0.032 13.7 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Spc7 PF08317.11 CDW58348.1 - 0.034 13.0 0.4 0.062 12.2 0.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_28 PF13521.6 CDW58348.1 - 0.034 14.4 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDW58348.1 - 0.043 13.0 0.0 0.11 11.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.16 CDW58348.1 - 0.046 13.2 0.0 0.45 9.9 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein APG6_N PF17675.1 CDW58348.1 - 0.049 14.2 1.0 0.11 13.0 1.0 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF2072 PF09845.9 CDW58348.1 - 0.077 13.2 1.0 0.18 12.0 1.0 1.6 1 0 0 1 1 1 0 Zn-ribbon containing protein FlaC_arch PF05377.11 CDW58348.1 - 0.089 13.2 4.1 0.2 12.1 1.7 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) AAA_11 PF13086.6 CDW58348.1 - 0.1 12.4 0.1 0.56 9.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDW58348.1 - 0.11 12.5 0.0 0.46 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDW58348.1 - 0.11 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 CDW58348.1 - 0.15 12.4 0.2 0.46 10.8 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_17 PF13207.6 CDW58348.1 - 0.16 12.4 1.8 1.2 9.5 0.0 2.7 3 0 0 3 3 3 0 AAA domain PLAT PF01477.23 CDW58349.1 - 8.5e-28 97.3 0.2 6.1e-14 52.6 0.0 4.2 4 0 0 4 4 4 3 PLAT/LH2 domain DCX PF03607.17 CDW58349.1 - 7.3e-25 86.8 0.0 4.2e-19 68.4 0.0 2.6 2 0 0 2 2 2 2 Doublecortin AHH PF14412.6 CDW58349.1 - 0.075 13.1 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH PHBC_N PF12551.8 CDW58350.1 - 0.0089 15.8 3.6 0.22 11.3 0.2 2.7 2 1 0 2 2 2 2 Poly-beta-hydroxybutyrate polymerase N terminal CTD_bind PF04818.13 CDW58351.1 - 0.00011 23.0 0.3 0.00029 21.6 0.3 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. AAA_9 PF12781.7 CDW58351.1 - 0.047 12.8 3.4 0.2 10.8 3.2 1.9 1 1 0 1 1 1 0 ATP-binding dynein motor region CSN5_C PF18323.1 CDW58351.1 - 0.067 14.1 0.2 0.71 10.8 0.1 2.4 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain Maf1 PF09174.10 CDW58351.1 - 0.2 11.8 2.6 2.5 8.2 1.0 2.2 2 0 0 2 2 2 0 Maf1 regulator MobL PF18555.1 CDW58351.1 - 1.4 8.1 8.0 1.3 8.2 3.9 2.0 2 0 0 2 2 2 0 MobL relaxases MIP-T3_C PF17749.1 CDW58351.1 - 1.6 8.7 5.2 5.5 6.9 0.3 2.4 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region Surp PF01805.20 CDW58352.1 - 1.6e-17 63.2 0.1 2.5e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 Surp module B12-binding PF02310.19 CDW58352.1 - 0.046 13.8 0.0 0.061 13.4 0.0 1.2 1 0 0 1 1 1 0 B12 binding domain ESCRT-II PF05871.12 CDW58353.1 - 6e-25 88.1 1.8 3.1e-12 46.9 0.1 2.5 1 1 1 2 2 2 2 ESCRT-II complex subunit DUF2789 PF10982.8 CDW58353.1 - 0.045 13.9 0.7 0.065 13.4 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2789) BAR PF03114.18 CDW58355.1 - 4.9e-10 39.5 5.9 5.9e-10 39.2 5.9 1.0 1 0 0 1 1 1 1 BAR domain PXA PF02194.15 CDW58355.1 - 0.17 11.9 1.9 0.3 11.0 1.9 1.6 1 1 0 1 1 1 0 PXA domain Pkinase PF00069.25 CDW58356.1 - 1.7e-26 93.2 0.0 2.1e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58356.1 - 9.9e-11 41.4 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW58356.1 - 0.0039 16.0 0.0 0.0053 15.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW58356.1 - 0.0047 16.9 0.0 0.0081 16.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Glycogen_syn PF05693.13 CDW58358.1 - 0 1072.8 0.0 0 1072.6 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 CDW58358.1 - 7e-06 25.7 0.0 0.00019 21.0 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDW58358.1 - 7.7e-06 26.0 0.3 1.8e-05 24.8 0.3 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CDW58358.1 - 4.6e-05 23.9 1.0 7.4e-05 23.2 0.1 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 CDW58358.1 - 5e-05 23.1 0.0 9.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 CDW58358.1 - 0.00043 20.7 0.0 0.01 16.3 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 SRA1 PF07304.11 CDW58359.1 - 0.064 13.1 0.2 0.13 12.0 0.2 1.5 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) Prefoldin PF02996.17 CDW58360.1 - 5.3e-10 39.3 0.0 1.3e-09 38.0 0.0 1.5 1 1 0 1 1 1 1 Prefoldin subunit DUF1011 PF06237.12 CDW58361.1 - 2e-26 92.2 8.3 2e-26 92.2 8.3 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1011) CrgA PF06781.12 CDW58361.1 - 2.9 8.0 9.0 14 5.8 0.0 4.2 3 1 1 4 4 4 0 Cell division protein CrgA Flavoprotein PF02441.19 CDW58362.1 - 8.3e-45 152.4 0.0 1.1e-44 152.0 0.0 1.1 1 0 0 1 1 1 1 Flavoprotein I-set PF07679.16 CDW58363.1 - 1.5e-37 127.5 0.0 3.1e-11 43.2 0.0 3.1 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 CDW58363.1 - 2.1e-22 79.5 0.0 2.7e-08 34.3 0.0 3.2 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 CDW58363.1 - 7.7e-16 58.0 0.0 0.0001 22.4 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 CDW58363.1 - 1.7e-11 44.3 0.0 0.011 16.1 0.0 4.2 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 CDW58363.1 - 2.2e-10 40.7 0.1 0.0063 16.7 0.0 3.8 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_6 PF18452.1 CDW58363.1 - 2.4e-06 27.0 0.0 0.18 11.4 0.0 3.6 3 0 0 3 3 3 2 Immunoglobulin domain Ig_5 PF16681.5 CDW58363.1 - 2.3e-05 24.7 1.0 1.6 9.2 0.1 4.1 3 2 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 CDW58363.1 - 0.0006 20.0 0.5 1.2 9.5 0.1 3.7 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Receptor_2B4 PF11465.8 CDW58363.1 - 0.00087 19.5 0.0 2.1 8.6 0.0 3.3 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 CDW58363.1 - 0.0028 17.7 0.1 3.4 7.8 0.0 3.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Mga PF05043.13 CDW58364.1 - 6.2e-12 45.9 2.4 6.2e-12 45.9 2.4 3.4 2 2 1 3 3 3 1 Mga helix-turn-helix domain HTH_Mga PF08280.11 CDW58364.1 - 0.0013 18.8 2.0 0.0049 16.9 0.6 2.5 2 0 0 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_24 PF13412.6 CDW58364.1 - 0.028 14.0 0.0 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 CDW58364.1 - 0.031 14.2 0.1 8.1 6.5 0.0 2.5 2 0 0 2 2 2 0 HTH domain VWA PF00092.28 CDW58365.1 - 2.8e-10 40.7 0.5 3.5e-09 37.2 0.1 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 CDW58365.1 - 1.5e-08 35.2 0.1 3.4e-08 34.1 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain TipAS PF07739.13 CDW58366.1 - 1.4e-25 90.1 9.9 1.4e-25 90.1 9.9 2.2 2 1 1 3 3 3 1 TipAS antibiotic-recognition domain MerR-DNA-bind PF09278.11 CDW58366.1 - 0.0076 16.8 1.5 0.0076 16.8 1.5 2.1 2 0 0 2 2 2 1 MerR, DNA binding Exonuc_VII_L PF02601.15 CDW58366.1 - 0.84 9.1 4.9 0.99 8.9 4.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GFO_IDH_MocA PF01408.22 CDW58367.1 - 1e-20 74.7 0.0 1.8e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 CDW58367.1 - 0.096 13.3 0.0 0.2 12.3 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Abhydrolase_3 PF07859.13 CDW58368.1 - 2.8e-32 112.3 0.0 3.3e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CDW58368.1 - 1.2e-11 44.2 0.0 3.5e-11 42.6 0.0 1.7 1 1 0 1 1 1 1 Steryl acetyl hydrolase Thioesterase PF00975.20 CDW58368.1 - 0.00047 20.3 0.0 0.00066 19.9 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Hydrolase_4 PF12146.8 CDW58368.1 - 0.0011 18.3 0.0 0.072 12.4 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Fe-ADH PF00465.19 CDW58369.1 - 9.8e-103 343.8 0.0 1.2e-102 343.5 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CDW58369.1 - 2e-17 63.7 0.5 6.1e-11 42.5 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peptidase_M4 PF01447.18 CDW58369.1 - 0.095 13.2 0.2 5.5 7.5 0.1 2.5 2 1 0 2 2 2 0 Thermolysin metallopeptidase, catalytic domain Peptidase_S9 PF00326.21 CDW58370.1 - 4.8e-09 36.0 0.0 8.8e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CDW58370.1 - 1.5e-08 34.2 0.0 5.2e-05 22.6 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDW58370.1 - 5.9e-07 29.4 0.0 0.0013 18.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW58370.1 - 4.3e-06 27.5 0.0 6.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CDW58370.1 - 8.1e-05 22.3 0.0 0.0017 17.9 0.0 2.4 1 1 1 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 CDW58370.1 - 0.0088 16.0 0.0 0.015 15.2 0.0 1.5 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 CDW58370.1 - 0.01 15.5 0.2 0.025 14.2 0.1 1.6 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF2048 PF09752.9 CDW58370.1 - 0.014 14.5 0.6 0.017 14.2 0.6 1.5 1 1 0 1 1 1 0 Abhydrolase domain containing 18 PNP_UDP_1 PF01048.20 CDW58371.1 - 8.3e-41 139.8 0.1 1e-40 139.5 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PNP_UDP_1 PF01048.20 CDW58372.1 - 8.7e-54 182.2 0.5 9.9e-54 182.1 0.5 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Glu_synthase PF01645.17 CDW58372.1 - 0.072 12.2 0.1 0.1 11.7 0.1 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase ABC_tran PF00005.27 CDW58373.1 - 8.1e-50 168.9 0.2 8.9e-31 107.2 0.1 2.4 2 0 0 2 2 2 2 ABC transporter BPD_transp_2 PF02653.16 CDW58373.1 - 1.7e-43 148.7 61.3 6.6e-33 114.0 35.5 3.1 3 0 0 3 3 3 2 Branched-chain amino acid transport system / permease component Metalloenzyme PF01676.18 CDW58373.1 - 8.3e-31 107.2 0.0 2e-30 106.0 0.0 1.6 1 1 0 1 1 1 1 Metalloenzyme superfamily AAA_21 PF13304.6 CDW58373.1 - 2.3e-06 27.7 0.1 0.025 14.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW58373.1 - 4.7e-05 23.0 0.4 0.00039 20.1 0.0 2.6 3 0 0 3 3 3 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDW58373.1 - 0.00055 19.9 3.5 0.0048 16.8 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 CDW58373.1 - 0.0013 18.5 0.6 0.09 12.5 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CDW58373.1 - 0.0025 18.3 0.0 0.0045 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_27 PF13514.6 CDW58373.1 - 0.0046 16.6 0.1 0.01 15.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 CDW58373.1 - 0.012 15.7 0.6 0.32 11.1 0.0 3.1 3 0 0 3 3 3 0 50S ribosome-binding GTPase SeleniumBinding PF11524.8 CDW58373.1 - 0.025 15.0 0.8 9.8 6.7 0.0 3.4 3 0 0 3 3 3 0 Selenium binding protein SMC_N PF02463.19 CDW58373.1 - 0.039 13.4 0.0 0.16 11.4 0.0 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Bmp PF02608.14 CDW58374.1 - 7.7e-70 235.2 12.3 9.8e-70 234.9 12.3 1.0 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like dCMP_cyt_deam_1 PF00383.23 CDW58375.1 - 1.4e-17 63.4 0.2 1.7e-17 63.1 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 CDW58375.1 - 2.4e-10 40.7 0.2 7.4e-10 39.1 0.0 1.7 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 CDW58375.1 - 0.00063 19.4 1.8 0.15 11.6 0.3 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases Glycos_transf_3 PF00591.21 CDW58376.1 - 9e-45 153.2 5.2 1.3e-44 152.7 5.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain PYNP_C PF07831.13 CDW58376.1 - 7.2e-27 92.9 0.8 1.7e-26 91.7 0.8 1.7 1 0 0 1 1 1 1 Pyrimidine nucleoside phosphorylase C-terminal domain Peripla_BP_3 PF13377.6 CDW58376.1 - 2.9e-22 79.8 0.0 6.5e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 Periplasmic binding protein-like domain Glycos_trans_3N PF02885.17 CDW58376.1 - 8.9e-22 76.7 2.1 1e-21 76.5 0.0 2.2 2 1 0 2 2 2 1 Glycosyl transferase family, helical bundle domain Peripla_BP_1 PF00532.21 CDW58376.1 - 1.1e-20 74.2 0.0 2.7e-20 73.0 0.0 1.6 2 0 0 2 2 2 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_4 PF13407.6 CDW58376.1 - 1.8e-15 57.2 0.0 9.2e-14 51.6 0.0 2.8 2 1 0 2 2 2 1 Periplasmic binding protein domain Biotin_lipoyl PF00364.22 CDW58376.1 - 0.00021 21.0 0.4 0.19 11.6 0.1 2.6 2 0 0 2 2 2 2 Biotin-requiring enzyme DUF2254 PF10011.9 CDW58376.1 - 0.083 11.7 0.0 0.16 10.8 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) FliG_N PF14842.6 CDW58376.1 - 0.12 12.9 1.0 22 5.7 0.0 3.6 4 0 0 4 4 4 0 FliG N-terminal domain DUF3349 PF11829.8 CDW58376.1 - 0.15 12.8 0.0 0.55 11.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) Abhydrolase_3 PF07859.13 CDW58377.1 - 4.3e-22 79.0 0.0 6.2e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CDW58377.1 - 2e-05 23.7 0.0 9.2e-05 21.5 0.0 1.9 3 0 0 3 3 3 1 Carboxylesterase family Peptidase_S9 PF00326.21 CDW58377.1 - 2e-05 24.2 0.0 0.0042 16.6 0.0 2.6 2 1 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CDW58377.1 - 3.1e-05 23.7 0.0 0.001 18.7 0.0 2.6 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 CDW58377.1 - 0.0023 17.6 0.2 0.0048 16.6 0.1 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW58377.1 - 0.0044 17.6 0.0 0.0053 17.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CDW58377.1 - 0.0079 15.8 0.0 4.2 6.9 0.0 3.0 3 0 0 3 3 3 1 Dienelactone hydrolase family Say1_Mug180 PF10340.9 CDW58377.1 - 0.0086 15.0 0.0 0.016 14.1 0.0 1.5 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 CDW58377.1 - 0.03 13.6 0.0 0.29 10.4 0.0 2.2 1 1 0 1 1 1 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 CDW58377.1 - 0.061 12.2 0.0 0.18 10.7 0.0 1.6 1 1 0 1 1 1 0 Chlorophyllase enzyme Bmp PF02608.14 CDW58377.1 - 0.074 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like MTS PF05175.14 CDW58378.1 - 3.6e-43 147.0 0.0 6.6e-43 146.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Lipase_GDSL_2 PF13472.6 CDW58378.1 - 6.2e-21 75.6 0.0 1.2e-20 74.6 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CDW58378.1 - 5.9e-14 52.5 0.2 1.5e-13 51.2 0.1 1.8 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase HTH_11 PF08279.12 CDW58378.1 - 8.2e-14 51.3 0.0 3.2e-13 49.4 0.0 2.1 1 0 0 1 1 1 1 HTH domain WYL PF13280.6 CDW58378.1 - 1.8e-13 50.9 0.3 4.4e-13 49.6 0.3 1.6 1 0 0 1 1 1 1 WYL domain Methyltransf_31 PF13847.6 CDW58378.1 - 5.7e-10 39.2 0.0 1.8e-09 37.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDW58378.1 - 6.7e-10 38.8 0.1 1.7e-09 37.5 0.0 1.6 2 0 0 2 2 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CDW58378.1 - 1.1e-09 38.9 0.2 9.8e-09 35.8 0.0 2.7 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW58378.1 - 2.2e-05 25.0 0.1 0.00015 22.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW58378.1 - 2.9e-05 24.0 0.0 0.00011 22.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain HTH_DeoR PF08220.12 CDW58378.1 - 0.00014 21.5 0.4 0.00046 19.9 0.1 2.1 2 0 0 2 2 1 1 DeoR-like helix-turn-helix domain UPF0020 PF01170.18 CDW58378.1 - 0.00082 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Rrf2 PF02082.20 CDW58378.1 - 0.0018 18.6 0.0 0.0048 17.2 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator Methyltransf_12 PF08242.12 CDW58378.1 - 0.0023 18.6 0.1 0.013 16.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 CDW58378.1 - 0.0024 17.2 0.0 0.008 15.5 0.0 1.8 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase GyrI-like PF06445.15 CDW58378.1 - 0.0032 17.8 1.1 0.0065 16.8 1.1 1.5 1 0 0 1 1 1 1 GyrI-like small molecule binding domain HTH_28 PF13518.6 CDW58378.1 - 0.0066 16.5 0.0 0.021 14.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain Methyltransf_32 PF13679.6 CDW58378.1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Lipase_GDSL_3 PF14606.6 CDW58378.1 - 0.0094 16.1 0.0 0.023 14.8 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Methyltransf_18 PF12847.7 CDW58378.1 - 0.012 15.5 0.1 0.026 14.5 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain TrmB PF01978.19 CDW58378.1 - 0.018 14.9 0.0 0.062 13.2 0.0 1.9 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Cons_hypoth95 PF03602.15 CDW58378.1 - 0.019 14.6 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical protein 95 HTH_23 PF13384.6 CDW58378.1 - 0.02 14.7 0.3 0.058 13.2 0.3 1.7 1 0 0 1 1 1 0 Homeodomain-like domain TehB PF03848.14 CDW58378.1 - 0.023 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB HTH_7 PF02796.15 CDW58378.1 - 0.025 14.7 0.2 0.083 13.0 0.2 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase TetR_N PF00440.23 CDW58378.1 - 0.031 14.1 0.2 1.5 8.7 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_20 PF12840.7 CDW58378.1 - 0.033 14.2 0.0 0.078 13.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Met_10 PF02475.16 CDW58378.1 - 0.038 13.7 0.0 0.1 12.3 0.0 1.7 2 0 0 2 2 1 0 Met-10+ like-protein RrnaAD PF00398.20 CDW58378.1 - 0.046 12.8 0.0 0.17 10.9 0.0 1.9 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase N6_N4_Mtase PF01555.18 CDW58378.1 - 0.061 13.0 0.0 0.31 10.7 0.0 2.2 3 0 0 3 3 2 0 DNA methylase Ubie_methyltran PF01209.18 CDW58378.1 - 0.092 12.1 0.0 0.2 11.0 0.0 1.6 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 CDW58378.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase HTH_29 PF13551.6 CDW58378.1 - 0.14 12.2 0.0 0.4 10.7 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix GrpB PF04229.14 CDW58379.1 - 2.5e-40 138.3 0.9 2.9e-40 138.1 0.9 1.0 1 0 0 1 1 1 1 GrpB protein Virulence_fact PF13769.6 CDW58379.1 - 0.067 13.4 0.4 10 6.4 0.2 2.3 2 0 0 2 2 2 0 Virulence factor PRK PF00485.18 CDW58380.1 - 1.5e-15 57.5 0.0 1.9e-14 53.9 0.0 2.1 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CDW58380.1 - 0.00012 22.6 0.1 0.0011 19.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain CoaE PF01121.20 CDW58380.1 - 0.083 12.6 0.1 0.17 11.5 0.1 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase GPI PF06560.11 CDW58380.1 - 0.11 11.8 0.2 0.3 10.4 0.1 1.8 2 0 0 2 2 2 0 Glucose-6-phosphate isomerase (GPI) GATase PF00117.28 CDW58381.1 - 6.4e-44 150.0 0.0 9.2e-44 149.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 CDW58381.1 - 9.9e-44 147.3 0.1 1.8e-43 146.5 0.1 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 CDW58381.1 - 9.5e-13 47.8 0.1 2.4e-08 33.4 0.1 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CDW58381.1 - 4.4e-11 42.9 0.0 1.5e-10 41.2 0.0 2.0 1 1 0 1 1 1 1 Peptidase C26 QueC PF06508.13 CDW58381.1 - 0.00014 21.5 0.0 0.00028 20.5 0.0 1.5 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 CDW58381.1 - 0.0011 17.8 0.1 0.0043 15.9 0.1 1.9 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.21 CDW58381.1 - 0.0038 17.0 0.1 0.0085 15.8 0.1 1.5 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.20 CDW58381.1 - 0.0067 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 PP-loop family Arginosuc_synth PF00764.19 CDW58381.1 - 0.052 12.8 0.1 0.078 12.3 0.1 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase PAPS_reduct PF01507.19 CDW58381.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Type_ISP_C PF18135.1 CDW58382.1 - 0.026 13.5 0.0 0.03 13.3 0.0 1.1 1 0 0 1 1 1 0 Type ISP C-terminal specificity domain HSP20 PF00011.21 CDW58384.1 - 8.1e-23 80.5 0.1 1.2e-22 79.9 0.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW58384.1 - 0.00076 19.0 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA DUF4214 PF13946.6 CDW58384.1 - 0.017 15.1 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) G6PD_bact PF10786.9 CDW58384.1 - 0.064 12.8 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) Exo_endo_phos PF03372.23 CDW58385.1 - 5.5e-16 58.8 0.0 1.4e-15 57.5 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Lactamase_B_4 PF13691.6 CDW58385.1 - 0.098 12.3 0.0 1 9.1 0.0 2.3 2 0 0 2 2 2 0 tRNase Z endonuclease Troponin PF00992.20 CDW58386.1 - 2.6e-44 150.8 20.3 2.6e-44 150.8 20.3 2.6 3 0 0 3 3 3 1 Troponin Prominin PF05478.11 CDW58386.1 - 0.2 9.6 9.6 0.25 9.2 9.6 1.1 1 0 0 1 1 1 0 Prominin RTC4 PF14474.6 CDW58386.1 - 0.59 10.3 7.0 0.12 12.5 1.2 2.3 2 0 0 2 2 2 0 RTC4-like domain IDO PF01231.18 CDW58387.1 - 1.2e-80 271.5 0.0 1.6e-79 267.8 0.0 1.9 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 CDW58387.1 - 0.0045 15.8 0.1 0.081 11.7 0.1 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1864) Acetyltransf_1 PF00583.25 CDW58388.1 - 1.9e-12 47.5 0.0 2.6e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW58388.1 - 1.7e-05 24.8 0.0 2.6e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW58388.1 - 1.8e-05 25.1 0.0 2.6e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDW58388.1 - 0.024 14.8 0.0 0.034 14.3 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDW58388.1 - 0.2 11.7 0.0 0.74 9.9 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain BRO1 PF03097.18 CDW58389.1 - 8.8e-90 301.3 4.4 1.1e-89 301.0 4.4 1.0 1 0 0 1 1 1 1 BRO1-like domain Cupin_2 PF07883.11 CDW58390.1 - 0.0011 18.6 0.0 0.0027 17.4 0.0 1.7 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CDW58390.1 - 0.002 17.8 0.0 0.0061 16.2 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Pirin_C PF05726.13 CDW58390.1 - 0.098 13.0 0.3 1.5 9.2 0.0 2.8 3 0 0 3 3 3 0 Pirin C-terminal cupin domain T-box PF00907.22 CDW58391.1 - 9.1e-75 251.0 0.0 1.1e-74 250.7 0.0 1.0 1 0 0 1 1 1 1 T-box DUF5331 PF17265.2 CDW58391.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5331) Utp11 PF03998.13 CDW58392.1 - 1.5e-08 34.9 4.1 1.8e-08 34.6 4.1 1.1 1 0 0 1 1 1 1 Utp11 protein PRTP PF01366.18 CDW58392.1 - 0.17 9.9 1.0 0.22 9.5 0.9 1.3 1 1 0 1 1 1 0 Herpesvirus processing and transport protein MecA PF05389.12 CDW58392.1 - 0.53 9.9 5.2 0.27 10.9 2.1 1.8 1 1 1 2 2 2 0 Negative regulator of genetic competence (MecA) UNC80 PF15778.5 CDW58393.1 - 1.6e-74 249.6 0.2 2.1e-74 249.2 0.2 1.2 1 0 0 1 1 1 1 Cation channel complex component UNC80 DSPc PF00782.20 CDW58394.1 - 3.7e-43 146.5 0.1 2.4e-42 143.9 0.1 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 CDW58394.1 - 1.2e-10 41.8 0.0 1.3e-09 38.6 0.0 2.4 3 0 0 3 3 3 1 Rhodanese-like domain Y_phosphatase PF00102.27 CDW58394.1 - 0.0002 21.0 0.0 0.00035 20.2 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CDW58394.1 - 0.0068 16.5 0.0 0.014 15.5 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 CDW58394.1 - 0.04 14.2 0.0 0.17 12.2 0.0 2.0 2 1 0 2 2 2 0 Rit1 DUSP-like domain MIF4G PF02854.19 CDW58395.1 - 1.6e-34 119.5 4.0 1.6e-34 119.5 4.0 1.8 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 CDW58395.1 - 0.00048 20.1 0.0 0.012 15.6 0.0 3.2 4 0 0 4 4 4 1 MA3 domain DUF2115 PF09888.9 CDW58395.1 - 0.91 10.0 4.3 5.3 7.5 2.3 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2115) PH PF00169.29 CDW58396.1 - 6.6e-13 49.1 0.0 8.2e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CDW58396.1 - 2e-06 28.2 0.0 3e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 CDW58396.1 - 0.031 14.6 0.0 0.043 14.1 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain PH_15 PF17339.2 CDW58396.1 - 0.094 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 PH domain PH_2 PF08458.10 CDW58396.1 - 0.14 12.5 0.0 0.24 11.8 0.0 1.4 1 1 0 1 1 1 0 Plant pleckstrin homology-like region Zip PF02535.22 CDW58397.1 - 1e-21 77.5 16.6 3.2e-21 75.9 16.6 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter ribosomal_L24 PF17136.4 CDW58397.1 - 3.9e-09 36.8 0.0 9e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 CDW58397.1 - 0.00076 19.3 0.2 0.002 18.0 0.2 1.7 1 0 0 1 1 1 1 KOW motif LAT PF15234.6 CDW58398.1 - 0.22 11.2 0.1 0.22 11.2 0.1 1.1 1 0 0 1 1 1 0 Linker for activation of T-cells Metallophos PF00149.28 CDW58399.1 - 3.3e-33 115.9 0.0 4.2e-33 115.6 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDW58399.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 CDW58399.1 - 0.19 12.2 0.1 1.6 9.2 0.0 2.4 3 0 0 3 3 3 0 Serine-threonine protein phosphatase N-terminal domain CPSF_A PF03178.15 CDW58400.1 - 3.2e-40 138.4 0.0 8e-39 133.8 0.0 2.2 2 0 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 CDW58400.1 - 2.2e-38 132.2 0.0 4e-38 131.3 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term bZIP_2 PF07716.15 CDW58400.1 - 5.4e-11 42.4 4.1 2.1e-10 40.5 4.1 2.1 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CDW58400.1 - 7.4e-09 35.6 3.5 7.4e-09 35.6 3.5 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 CDW58400.1 - 0.00029 21.3 7.6 0.00063 20.2 7.6 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 CDW58400.1 - 0.021 15.3 0.1 0.043 14.3 0.1 1.5 1 0 0 1 1 1 0 Cell division protein ZapB MENTAL PF10457.9 CDW58401.1 - 1.8e-29 102.8 3.7 3.1e-29 102.1 3.7 1.4 1 0 0 1 1 1 1 Cholesterol-capturing domain START PF01852.19 CDW58401.1 - 6.4e-19 68.2 0.0 9.1e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 START domain RhoGEF PF00621.20 CDW58402.1 - 2.8e-45 154.8 1.9 5.5e-45 153.8 1.9 1.5 1 0 0 1 1 1 1 RhoGEF domain IQ_SEC7_PH PF16453.5 CDW58402.1 - 0.00076 19.5 0.1 0.0021 18.0 0.1 1.7 1 0 0 1 1 1 1 PH domain TraB PF01963.17 CDW58403.1 - 1.2e-58 199.1 0.0 2.6e-58 198.0 0.0 1.5 1 1 0 1 1 1 1 TraB family RAB3GAP2_N PF14655.6 CDW58404.1 - 7.3e-07 28.8 0.0 8.2e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus RAB3GAP2_N PF14655.6 CDW58405.1 - 4.3e-29 102.0 0.1 7.1e-29 101.3 0.1 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus RAB3GAP2_C PF14656.6 CDW58405.1 - 6.9e-18 64.2 8.5 1.1e-08 33.8 1.7 3.2 2 1 1 3 3 3 3 Rab3 GTPase-activating protein regulatory subunit C-terminus Med13_C PF06333.12 CDW58406.1 - 1.4e-63 215.2 0.0 3.7e-63 213.8 0.0 1.7 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 CDW58406.1 - 6.2e-51 173.6 0.1 4.1e-50 170.9 0.0 2.5 2 0 0 2 2 2 1 MID domain of medPIWI zf-C2H2_jaz PF12171.8 CDW58407.1 - 3.6e-07 30.3 1.7 6e-07 29.6 1.7 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW58407.1 - 2.3e-06 27.8 1.3 3.6e-06 27.2 1.3 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 CDW58407.1 - 0.00021 21.0 1.5 0.0004 20.1 1.5 1.4 1 0 0 1 1 1 1 U1 zinc finger SNRNP27 PF08648.12 CDW58407.1 - 0.013 15.5 1.3 0.045 13.8 0.2 2.2 2 0 0 2 2 2 0 U4/U6.U5 small nuclear ribonucleoproteins ATP-synt_F6 PF05511.11 CDW58407.1 - 0.015 15.7 0.5 0.028 14.8 0.5 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase coupling factor 6 Sperm_Ag_HE2 PF05324.13 CDW58407.1 - 0.79 10.2 2.2 7.9 7.0 0.3 2.2 2 0 0 2 2 2 0 Sperm antigen HE2 Pkinase PF00069.25 CDW58408.1 - 1.1e-27 97.1 0.0 1.7e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58408.1 - 1.6e-27 96.5 0.0 4.2e-27 95.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW58408.1 - 0.0077 15.1 0.0 0.058 12.2 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase zf-C3HC4 PF00097.25 CDW58409.1 - 6.2e-07 29.2 11.7 1.8e-06 27.7 11.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW58409.1 - 1.9e-06 27.8 5.3 1.9e-06 27.8 5.3 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW58409.1 - 2.2e-06 27.4 13.8 5.1e-06 26.2 13.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW58409.1 - 6.6e-06 26.4 11.3 1.9e-05 24.9 11.3 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CDW58409.1 - 3.9e-05 23.5 10.7 0.00012 22.0 10.7 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDW58409.1 - 0.00015 21.5 12.4 0.00041 20.1 12.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW58409.1 - 0.0039 17.0 12.8 0.0088 15.9 11.6 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDW58409.1 - 0.011 15.9 11.3 0.029 14.5 11.3 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 CDW58409.1 - 0.087 12.7 6.7 0.19 11.6 6.7 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 CDW58409.1 - 0.48 10.2 10.1 1.4 8.7 10.1 1.8 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger PHD PF00628.29 CDW58410.1 - 1.6e-08 34.3 15.7 2.7e-08 33.6 14.4 2.1 1 1 1 2 2 2 2 PHD-finger Bromo_TP PF07524.13 CDW58410.1 - 2.8e-06 27.2 0.0 4.7e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated PHD_2 PF13831.6 CDW58410.1 - 0.00026 20.5 9.1 0.00026 20.5 9.1 2.4 2 0 0 2 2 2 1 PHD-finger SWIB PF02201.18 CDW58411.1 - 1.2e-19 70.0 0.4 3.2e-19 68.6 0.1 1.9 2 0 0 2 2 2 1 SWIB/MDM2 domain PH_16 PF17838.1 CDW58412.1 - 1.2e-35 122.1 0.2 2.5e-35 121.0 0.1 1.7 2 0 0 2 2 2 1 PH domain PH PF00169.29 CDW58412.1 - 0.015 15.8 0.0 0.028 14.9 0.0 1.5 1 0 0 1 1 1 0 PH domain YedD PF13987.6 CDW58412.1 - 0.02 14.7 0.0 0.054 13.3 0.0 1.7 1 0 0 1 1 1 0 YedD-like protein GM_CSF PF01109.17 CDW58412.1 - 0.078 13.1 0.7 3.5 7.8 0.4 2.4 2 0 0 2 2 2 0 Granulocyte-macrophage colony-stimulating factor Dala_Dala_lig_C PF07478.13 CDW58412.1 - 0.13 11.7 0.2 0.21 11.1 0.2 1.2 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus Iso_dh PF00180.20 CDW58413.1 - 5e-66 223.2 0.0 6.1e-66 222.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Glutaminase PF04960.15 CDW58414.1 - 6.3e-105 350.5 0.0 2.4e-103 345.3 0.0 2.1 1 1 0 1 1 1 1 Glutaminase EF-hand_14 PF17959.1 CDW58414.1 - 2.9e-25 88.4 0.7 6.4e-25 87.3 0.7 1.6 1 0 0 1 1 1 1 EF-hand domain Ank_2 PF12796.7 CDW58414.1 - 3.6e-09 37.1 0.0 9.4e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CDW58414.1 - 9.8e-08 32.4 0.1 3.1e-07 30.8 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 CDW58414.1 - 3.6e-06 27.2 0.2 4e-05 23.9 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 CDW58414.1 - 9.5e-05 22.6 0.0 0.00046 20.4 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW58414.1 - 0.00016 21.8 0.0 0.0014 18.9 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat LRR_8 PF13855.6 CDW58415.1 - 5.5e-23 80.5 33.5 1e-11 44.4 9.0 5.7 4 2 2 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 CDW58415.1 - 1.6e-15 56.9 31.9 0.001 19.4 0.2 7.7 4 3 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CDW58415.1 - 3.3e-07 29.8 23.5 15 5.9 0.1 10.4 11 0 0 11 11 11 1 Leucine Rich repeat LRR_1 PF00560.33 CDW58415.1 - 1.2e-05 25.1 25.5 13 6.8 0.0 10.2 8 3 0 8 8 8 1 Leucine Rich Repeat LRR_5 PF13306.6 CDW58415.1 - 5.2e-05 23.2 0.0 0.005 16.8 0.0 2.7 1 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 CDW58415.1 - 0.00055 19.5 10.7 0.032 13.8 0.6 4.0 3 1 1 4 4 4 2 Leucine-rich repeat FNIP PF05725.12 CDW58415.1 - 0.055 13.6 2.2 0.16 12.2 0.6 2.6 2 0 0 2 2 2 0 FNIP Repeat FAM184 PF15665.5 CDW58415.1 - 0.54 10.0 4.6 2.5 7.8 4.6 1.8 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B Exonuc_VII_L PF02601.15 CDW58415.1 - 0.59 9.6 5.0 0.93 9.0 5.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4709 PF15821.5 CDW58415.1 - 5 7.4 8.7 0.55 10.5 2.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4709) DUF1647 PF07801.11 CDW58416.1 - 1.7e-26 92.7 0.1 2.3e-26 92.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) DUF928 PF06051.12 CDW58416.1 - 0.083 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) UPF0154 PF03672.13 CDW58416.1 - 0.1 12.6 0.0 0.92 9.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) CSF-1 PF05337.11 CDW58416.1 - 0.16 12.1 0.1 1.3 9.2 0.1 2.0 1 1 0 1 1 1 0 Macrophage colony stimulating factor-1 (CSF-1) DUF1647 PF07801.11 CDW58419.1 - 4.4e-25 88.1 0.2 5.9e-25 87.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) DUF928 PF06051.12 CDW58419.1 - 0.22 11.4 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Acyl_transf_1 PF00698.21 CDW58420.1 - 8.2e-19 68.3 0.3 1.4e-18 67.4 0.3 1.4 1 1 0 1 1 1 1 Acyl transferase domain DUF1647 PF07801.11 CDW58421.1 - 4.2e-26 91.4 0.0 6.5e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1647) Chromadorea_ALT PF05535.12 CDW58421.1 - 0.17 12.1 0.4 0.36 11.1 0.4 1.5 1 0 0 1 1 1 0 Chromadorea ALT protein MLVIN_C PF18697.1 CDW58423.1 - 0.028 14.5 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain rRNA_proc-arch PF13234.6 CDW58424.1 - 2.5e-72 244.1 0.2 2.5e-72 244.1 0.2 1.6 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 CDW58424.1 - 1.2e-49 168.2 0.7 3.2e-49 166.8 0.7 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 CDW58424.1 - 4.2e-17 62.5 0.0 9.8e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDW58424.1 - 0.00011 22.2 0.0 0.00028 20.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDW58424.1 - 0.00094 19.5 0.0 0.0046 17.3 0.0 2.3 1 1 0 1 1 1 1 Helicase conserved C-terminal domain T2SSE PF00437.20 CDW58424.1 - 0.03 13.4 0.0 0.33 9.9 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein SET PF00856.28 CDW58425.1 - 2.8e-22 79.9 1.2 2.8e-22 79.9 1.2 2.3 2 2 0 2 2 2 1 SET domain Cob_adeno_trans PF01923.18 CDW58426.1 - 2.7e-49 167.5 0.0 3.5e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Cobalamin adenosyltransferase DUF2045 PF09741.9 CDW58426.1 - 0.034 13.5 0.0 0.048 13.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2045) INTS2 PF14750.6 CDW58427.1 - 2.5e-195 651.1 12.5 3.3e-195 650.8 12.5 1.0 1 0 0 1 1 1 1 Integrator complex subunit 2 Calponin PF00402.18 CDW58428.1 - 6.6e-73 239.9 53.3 8.7e-11 41.3 1.1 7.2 7 0 0 7 7 7 7 Calponin family repeat CP_ATPgrasp_1 PF04174.13 CDW58428.1 - 0.0013 17.8 0.0 0.15 11.0 0.0 2.2 2 0 0 2 2 2 2 A circularly permuted ATPgrasp DUF190 PF02641.15 CDW58428.1 - 0.67 10.3 5.7 19 5.6 0.0 4.8 6 1 1 7 7 7 0 Uncharacterized ACR, COG1993 Pkinase PF00069.25 CDW58429.1 - 2.2e-70 237.1 0.0 2.9e-70 236.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58429.1 - 1.3e-33 116.4 0.0 2e-33 115.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 CDW58429.1 - 1.6e-26 91.9 15.5 6.6e-14 51.5 5.6 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CDW58429.1 - 7.1e-06 26.3 12.7 0.0012 19.1 2.4 2.6 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.6 CDW58429.1 - 0.00015 21.1 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDW58429.1 - 0.0006 19.2 0.0 0.00095 18.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PH PF00169.29 CDW58429.1 - 0.045 14.3 0.1 0.15 12.6 0.0 1.9 2 0 0 2 2 2 0 PH domain PHD PF00628.29 CDW58429.1 - 0.12 12.3 17.8 0.69 9.9 3.6 2.7 2 0 0 2 2 2 0 PHD-finger APH PF01636.23 CDW58429.1 - 0.13 12.2 0.0 1.3 8.9 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family PHD_2 PF13831.6 CDW58429.1 - 0.2 11.2 17.5 0.11 12.0 1.3 3.1 3 0 0 3 3 2 0 PHD-finger zf-RING_9 PF13901.6 CDW58429.1 - 0.23 11.4 14.2 0.83 9.6 2.5 2.5 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon FYVE_2 PF02318.16 CDW58429.1 - 0.37 11.0 15.6 0.49 10.6 4.4 2.8 3 0 0 3 3 3 0 FYVE-type zinc finger zf-RING-like PF08746.11 CDW58429.1 - 1.2 9.5 25.2 0.84 10.0 6.9 3.4 3 0 0 3 3 3 0 RING-like domain PHD_4 PF16866.5 CDW58429.1 - 4.5 7.4 7.5 16 5.7 0.4 2.9 3 0 0 3 3 2 0 PHD-finger Methyltransf_25 PF13649.6 CDW58431.1 - 0.025 15.3 0.0 0.042 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Cytochrom_B561 PF03188.16 CDW58432.1 - 2.5e-08 34.2 0.5 5.4e-08 33.1 0.5 1.5 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF2975 PF11188.8 CDW58432.1 - 0.064 13.1 2.6 0.21 11.5 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) Saf_2TM PF18303.1 CDW58432.1 - 0.07 12.7 0.5 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF998 PF06197.13 CDW58432.1 - 0.084 12.5 3.0 0.35 10.4 3.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF998) Ni_hydr_CYTB PF01292.20 CDW58432.1 - 0.14 11.7 1.1 0.3 10.7 1.1 1.7 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 DOMON PF03351.17 CDW58432.1 - 0.17 12.1 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 DOMON domain HCO3_cotransp PF00955.21 CDW58433.1 - 7.6e-147 490.2 5.0 2.2e-146 488.7 5.0 1.7 1 1 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 CDW58433.1 - 3.5e-57 194.3 0.0 4.4e-56 190.6 0.0 2.2 1 1 0 1 1 1 1 Band 3 cytoplasmic domain Headcase PF16002.5 CDW58434.1 - 3.5e-70 235.5 8.4 4e-70 235.3 8.4 1.0 1 0 0 1 1 1 1 Headcase protein Zn_Tnp_IS1595 PF12760.7 CDW58434.1 - 0.067 13.2 0.1 0.067 13.2 0.1 3.8 3 1 0 3 3 3 0 Transposase zinc-ribbon domain adh_short PF00106.25 CDW58435.1 - 1.3e-23 83.5 0.0 1.7e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW58435.1 - 2.4e-14 53.5 0.0 2.9e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW58435.1 - 7.2e-07 29.3 0.3 2.3e-06 27.6 0.3 1.7 1 1 0 1 1 1 1 KR domain Methyltransf_8 PF05148.15 CDW58436.1 - 6.6e-66 222.3 0.3 9.9e-66 221.7 0.0 1.4 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CDW58436.1 - 0.0022 18.6 0.1 0.063 13.9 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW58436.1 - 0.054 13.3 0.0 0.13 12.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CDW58436.1 - 0.079 13.7 0.1 4.5 8.0 0.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 CDW58436.1 - 0.24 11.2 1.1 2.9 7.7 0.1 2.4 1 1 1 2 2 2 0 Methyltransferase domain ORC_WH_C PF18137.1 CDW58437.1 - 1.1e-05 25.5 0.1 0.15 12.1 0.0 2.9 2 1 1 3 3 3 2 Origin recognition complex winged helix C-terminal RNB PF00773.19 CDW58437.1 - 0.087 12.1 0.2 0.25 10.6 0.2 2.0 1 1 0 1 1 1 0 RNB domain PDCD2_C PF04194.13 CDW58438.1 - 1.4e-44 152.2 7.8 1e-42 146.2 4.4 2.4 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 CDW58438.1 - 6e-09 35.9 9.7 6e-09 35.9 9.7 3.4 3 1 0 3 3 3 1 MYND finger CBF PF03914.17 CDW58438.1 - 0.004 17.2 0.1 0.0066 16.5 0.1 1.3 1 0 0 1 1 1 1 CBF/Mak21 family AdoHcyase PF05221.17 CDW58439.1 - 8e-133 442.2 0.0 2.6e-72 243.5 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CDW58439.1 - 1.3e-81 272.5 0.3 2.4e-81 271.6 0.3 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDW58439.1 - 8.9e-06 25.2 0.0 1.7e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CDW58439.1 - 0.0084 16.4 0.0 0.021 15.1 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain IlvN PF07991.12 CDW58439.1 - 0.031 13.9 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Pyr_redox PF00070.27 CDW58439.1 - 0.2 12.3 0.3 15 6.2 0.1 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase LIM PF00412.22 CDW58440.1 - 2.6e-29 101.2 21.8 1.8e-15 56.9 3.5 2.5 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 CDW58440.1 - 1.6e-15 56.7 0.5 4.5e-15 55.2 0.2 2.0 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CDW58440.1 - 2.2e-05 24.2 0.0 8.1e-05 22.4 0.0 2.0 1 0 0 1 1 1 1 Homeobox KN domain NAD_binding_1 PF00175.21 CDW58440.1 - 0.044 14.4 0.4 0.22 12.2 0.1 2.0 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Phage_rep_O PF04492.13 CDW58440.1 - 0.11 13.1 0.2 0.23 12.1 0.2 1.5 1 0 0 1 1 1 0 Bacteriophage replication protein O SpoU_sub_bind PF08032.12 CDW58440.1 - 0.17 12.2 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding NinD PF17466.2 CDW58440.1 - 3.5 7.8 7.3 1.2 9.3 0.3 2.5 2 0 0 2 2 2 0 Family of unknown function Vps39_2 PF10367.9 CDW58440.1 - 6.7 7.2 11.8 7.7 7.0 1.7 3.1 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 Peptidase_M14 PF00246.24 CDW58441.1 - 1.4e-76 258.1 0.0 1.8e-76 257.8 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase ShK PF01549.24 CDW58441.1 - 0.019 15.5 3.6 0.048 14.2 3.6 1.7 1 0 0 1 1 1 0 ShK domain-like Propep_M14 PF02244.16 CDW58441.1 - 0.032 14.6 0.1 0.083 13.3 0.1 1.7 1 0 0 1 1 1 0 Carboxypeptidase activation peptide Noggin PF05806.12 CDW58442.1 - 0.00032 20.7 2.2 0.0096 15.9 1.3 2.2 2 0 0 2 2 2 2 Noggin Y_phosphatase PF00102.27 CDW58443.1 - 2.2e-132 439.8 0.2 5.4e-69 232.3 0.1 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CDW58443.1 - 5.3e-08 33.1 0.0 0.00084 19.4 0.0 2.6 2 1 0 2 2 2 2 Tyrosine phosphatase family DSPc PF00782.20 CDW58443.1 - 1e-06 28.6 0.0 0.003 17.4 0.0 2.5 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW58443.1 - 0.00086 19.4 0.0 0.12 12.5 0.0 2.5 2 0 0 2 2 2 1 Inositol hexakisphosphate Myotub-related PF06602.14 CDW58443.1 - 0.0047 15.9 0.2 2.5 6.9 0.0 2.9 3 0 0 3 3 3 2 Myotubularin-like phosphatase domain Comm PF15957.5 CDW58443.1 - 0.044 14.1 0.2 0.24 11.7 0.0 2.3 2 0 0 2 2 2 0 Commissureless Chromo PF00385.24 CDW58444.1 - 3.5e-15 55.6 1.4 5.3e-15 55.1 1.4 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 CDW58444.1 - 9.2e-05 22.3 1.5 0.00015 21.6 1.5 1.3 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 CDW58444.1 - 0.006 16.7 0.2 0.011 15.9 0.2 1.3 1 0 0 1 1 1 1 Polycomb-like MTF2 factor 2 SKICH PF17751.1 CDW58445.1 - 7.2e-12 45.8 0.0 1.5e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 SKICH domain Exo_endo_phos PF03372.23 CDW58445.1 - 6.1e-05 22.7 0.0 0.00012 21.7 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC PF00098.23 CDW58446.1 - 0.00018 21.4 0.6 0.00028 20.8 0.6 1.3 1 0 0 1 1 1 1 Zinc knuckle Retrotran_gag_2 PF14223.6 CDW58446.1 - 0.011 15.4 0.0 0.034 13.8 0.0 1.7 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type PNMA PF14893.6 CDW58446.1 - 0.08 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 PNMA zf-CCHC_2 PF13696.6 CDW58446.1 - 0.22 11.4 0.2 0.39 10.6 0.2 1.4 1 0 0 1 1 1 0 Zinc knuckle DDT PF02791.17 CDW58447.1 - 9.2e-14 51.5 3.6 2.5e-13 50.1 3.6 1.8 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 CDW58447.1 - 0.018 14.5 0.0 0.04 13.5 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 PHD PF00628.29 CDW58448.1 - 0.00018 21.4 7.0 0.00045 20.1 7.0 1.7 1 0 0 1 1 1 1 PHD-finger WSD PF15613.6 CDW58448.1 - 0.0028 18.1 0.2 0.018 15.5 0.2 2.3 1 1 0 1 1 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif ACI44 PF15270.6 CDW58448.1 - 0.046 13.9 1.5 0.046 13.9 1.5 1.9 2 0 0 2 2 2 0 Metallo-carboxypeptidase inhibitor PHD_4 PF16866.5 CDW58448.1 - 0.048 13.7 4.9 0.15 12.2 4.9 1.8 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 CDW58448.1 - 3.4 7.7 15.0 0.21 11.5 1.6 3.5 5 0 0 5 5 5 0 Prokaryotic RING finger family 1 Gln-synt_C-ter PF18318.1 CDW58449.1 - 0.0018 18.1 0.4 0.0044 16.9 0.1 1.7 2 0 0 2 2 2 1 Glutamine synthetase C-terminal domain PHD PF00628.29 CDW58450.1 - 3e-12 46.2 32.9 1.3e-07 31.4 4.9 3.1 4 0 0 4 4 4 2 PHD-finger Bromodomain PF00439.25 CDW58450.1 - 0.00014 21.8 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 Bromodomain 7tm_1 PF00001.21 CDW58451.1 - 6.6e-35 120.7 18.0 5.2e-28 98.1 8.8 2.3 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 CDW58451.1 - 2.2e-07 30.5 17.5 4.2e-05 23.0 0.8 2.3 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_4 PF13853.6 CDW58451.1 - 0.00096 19.0 4.9 0.0019 18.0 4.9 1.4 1 0 0 1 1 1 1 Olfactory receptor Serpentine_r_xa PF03383.15 CDW58451.1 - 7.8 6.5 13.3 0.11 12.5 1.1 3.0 2 1 1 3 3 3 0 Caenorhabditis serpentine receptor-like protein, class xa Trypsin PF00089.26 CDW58452.1 - 1.5e-17 64.2 0.0 2.3e-06 27.6 0.0 3.4 3 0 0 3 3 3 3 Trypsin CRAL_TRIO PF00650.20 CDW58454.1 - 2e-35 121.8 0.0 3.9e-35 120.9 0.0 1.5 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 CDW58454.1 - 5.9e-08 33.0 0.0 1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Tropomyosin PF00261.20 CDW58455.1 - 2.6e-168 557.3 161.7 5.5e-85 284.5 60.1 4.5 3 2 1 4 4 4 4 Tropomyosin Tropomyosin_1 PF12718.7 CDW58455.1 - 1.1e-45 155.2 148.1 1.6e-28 99.6 44.6 6.0 3 2 2 5 5 5 5 Tropomyosin like Laminin_II PF06009.12 CDW58455.1 - 6.1e-06 26.3 70.4 0.12 12.4 14.4 6.8 3 2 2 6 6 6 6 Laminin Domain II CLZ PF16526.5 CDW58455.1 - 0.0033 17.7 13.1 0.0033 17.7 13.1 10.0 5 4 5 10 10 10 3 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fez1 PF06818.15 CDW58455.1 - 0.014 15.9 18.3 0.014 15.9 18.3 4.4 3 1 1 4 4 4 0 Fez1 LuxT_C PF18285.1 CDW58455.1 - 0.018 15.5 2.6 3.3 8.3 0.3 3.5 2 0 0 2 2 2 0 Tetracycline repressor LuxT C-terminal domain Nterm_IS4 PF13006.7 CDW58455.1 - 0.85 9.9 6.6 15 5.9 0.0 4.5 4 0 0 4 4 4 0 Insertion element 4 transposase N-terminal DUF745 PF05335.13 CDW58455.1 - 2.1 8.1 102.2 0.41 10.4 24.4 6.3 3 2 3 6 6 6 0 Protein of unknown function (DUF745) DUF1794 PF08768.11 CDW58455.1 - 2.8 7.9 11.3 40 4.1 0.1 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1794) SAT PF16073.5 CDW58455.1 - 3.4 7.3 7.3 4.9 6.8 1.0 2.9 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis DUF1664 PF07889.12 CDW58455.1 - 9.4 6.3 64.2 0.87 9.6 1.9 6.8 3 2 2 6 6 6 0 Protein of unknown function (DUF1664) HAD_2 PF13419.6 CDW58457.1 - 3.2e-19 69.7 0.0 3.9e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW58457.1 - 1.7e-10 41.5 0.0 4e-10 40.3 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW58457.1 - 6.6e-05 23.4 0.0 8.2e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW58457.1 - 0.0031 17.5 0.0 0.0062 16.6 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 CDW58457.1 - 0.039 14.0 0.0 13 5.9 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF668 PF05003.12 CDW58457.1 - 0.049 14.1 0.1 0.11 12.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF668) DAGAT PF03982.13 CDW58459.1 - 4.7e-117 390.1 0.1 5.8e-117 389.8 0.1 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Choline_transpo PF04515.12 CDW58459.1 - 0.017 14.3 0.2 0.025 13.8 0.2 1.3 1 0 0 1 1 1 0 Plasma-membrane choline transporter AIP3 PF03915.13 CDW58461.1 - 6.5e-14 51.8 7.3 6.5e-14 51.8 7.3 1.7 2 0 0 2 2 2 1 Actin interacting protein 3 zf-B_box PF00643.24 CDW58461.1 - 6.4e-08 32.6 14.9 7.5e-08 32.4 7.5 2.8 2 0 0 2 2 2 1 B-box zinc finger DUF1465 PF07323.12 CDW58461.1 - 0.02 14.8 0.2 0.064 13.1 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) RasGEF PF00617.19 CDW58461.1 - 0.026 14.8 0.6 0.066 13.4 0.2 2.0 2 0 0 2 2 2 0 RasGEF domain Cytochrom_B562 PF07361.11 CDW58461.1 - 0.21 12.2 1.5 19 5.9 0.1 3.2 2 1 2 4 4 4 0 Cytochrome b562 STAT_alpha PF01017.20 CDW58461.1 - 2.4 8.0 16.2 2 8.3 0.9 2.8 2 1 1 3 3 3 0 STAT protein, all-alpha domain DHHC PF01529.20 CDW58464.1 - 1.3e-36 125.6 16.1 1.8e-36 125.2 16.1 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase NMT_C PF02799.15 CDW58466.1 - 6.8e-77 257.7 0.2 1e-76 257.1 0.2 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 CDW58466.1 - 2.8e-76 254.8 0.0 5e-76 254.0 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 CDW58466.1 - 0.003 17.6 0.1 0.052 13.6 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDW58466.1 - 0.055 13.7 0.0 0.17 12.2 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Ubie_methyltran PF01209.18 CDW58467.1 - 5.5e-76 255.0 0.0 6.1e-76 254.8 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CDW58467.1 - 3.9e-18 65.9 0.0 9.2e-18 64.7 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW58467.1 - 1.4e-16 60.9 0.0 2.3e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW58467.1 - 9.5e-14 51.5 0.0 1.1e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW58467.1 - 9.4e-10 39.1 0.0 1.3e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW58467.1 - 1.4e-08 34.7 0.0 2.1e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CDW58467.1 - 0.013 15.1 0.1 0.035 13.7 0.1 1.9 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 CDW58467.1 - 0.014 15.2 0.0 0.065 13.1 0.0 2.2 2 1 0 2 2 2 0 Hypothetical methyltransferase MTS PF05175.14 CDW58467.1 - 0.046 13.3 0.0 0.094 12.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain IF4E PF01652.18 CDW58468.1 - 7.3e-32 110.4 0.4 1.2e-31 109.7 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E RNA_pol_3_Rpc31 PF11705.8 CDW58468.1 - 1.5e-07 31.9 13.4 1.5e-07 31.9 13.4 2.9 2 1 1 3 3 3 1 DNA-directed RNA polymerase III subunit Rpc31 RRM_1 PF00076.22 CDW58469.1 - 7.6e-15 54.5 0.0 9.1e-15 54.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 CDW58469.1 - 0.15 11.8 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain CYTH PF01928.21 CDW58470.1 - 0.026 14.5 0.0 0.042 13.8 0.0 1.3 1 0 0 1 1 1 0 CYTH domain SWIRM-assoc_2 PF16496.5 CDW58470.1 - 0.38 9.6 10.9 0.57 9.0 10.9 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal MAP65_ASE1 PF03999.12 CDW58470.1 - 1.9 7.1 13.2 2.3 6.8 13.2 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Occludin_ELL PF07303.13 CDW58471.1 - 0.016 15.9 6.5 0.087 13.6 0.2 2.9 2 1 0 2 2 2 0 Occludin homology domain BLOC1_2 PF10046.9 CDW58471.1 - 0.38 11.1 0.1 0.38 11.1 0.1 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mid2 PF04478.12 CDW58472.1 - 0.085 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor CcmD PF04995.14 CDW58472.1 - 0.09 12.9 1.5 0.14 12.2 1.5 1.3 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) FLYWCH PF04500.16 CDW58473.1 - 3e-10 40.1 5.9 5.3e-10 39.3 5.9 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain DUF1936 PF09151.10 CDW58473.1 - 1.4 8.9 3.6 0.69 9.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) DUF5522 PF17653.1 CDW58474.1 - 9.3e-20 70.3 3.1 1.7e-19 69.5 3.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5522) FtsQ PF03799.15 CDW58474.1 - 0.16 12.8 0.1 0.23 12.3 0.1 1.3 1 0 0 1 1 1 0 Cell division protein FtsQ Glyco_transf_10 PF00852.19 CDW58476.1 - 8.4e-165 543.5 6.0 1.8e-54 184.1 0.2 3.6 3 0 0 3 3 3 3 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW58476.1 - 4.3e-101 333.0 7.1 1.6e-24 86.5 0.0 4.6 4 0 0 4 4 4 4 Fucosyltransferase, N-terminal Exostosin PF03016.15 CDW58476.1 - 1.7e-08 34.0 0.9 0.04 13.1 0.0 3.2 3 0 0 3 3 3 3 Exostosin family IL11 PF07400.11 CDW58476.1 - 5.4e-07 29.4 0.3 1.2 8.8 0.0 3.5 3 0 0 3 3 3 3 Interleukin 11 DnaB_bind PF10410.9 CDW58476.1 - 8.9e-05 22.6 0.0 2.4 8.4 0.0 3.9 3 0 0 3 3 3 1 DnaB-helicase binding domain of primase BACK PF07707.15 CDW58476.1 - 0.00066 19.8 0.1 7.4 6.7 0.0 3.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch Arm_3 PF16186.5 CDW58476.1 - 0.00099 18.6 0.5 2.8 7.6 0.1 3.4 3 0 0 3 3 3 1 Atypical Arm repeat Mst1_SARAH PF11629.8 CDW58476.1 - 0.0011 19.1 2.4 14 5.9 0.1 3.7 3 0 0 3 3 3 1 C terminal SARAH domain of Mst1 CarD_CdnL_TRCF PF02559.16 CDW58476.1 - 0.0018 19.0 0.5 18 6.1 0.0 4.3 4 0 0 4 4 4 0 CarD-like/TRCF domain Ribonuc_red_lgN PF00317.21 CDW58476.1 - 0.016 15.2 0.2 20 5.3 0.0 3.5 3 0 0 3 3 3 0 Ribonucleotide reductase, all-alpha domain Hormone_3 PF00159.18 CDW58476.1 - 0.032 14.3 1.9 58 3.9 0.0 4.2 4 0 0 4 4 4 0 Pancreatic hormone peptide IncD PF17628.2 CDW58476.1 - 0.061 13.1 0.1 63 3.3 0.0 3.4 3 0 0 3 3 3 0 Inclusion membrane protein D Peptidase_S24 PF00717.23 CDW58476.1 - 0.061 13.3 0.0 49 4.0 0.0 3.6 3 0 0 3 3 3 0 Peptidase S24-like PDZ PF00595.24 CDW58477.1 - 1.5e-06 28.5 0.0 2.8e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW58477.1 - 2.3e-05 24.1 0.0 4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW58477.1 - 0.005 17.1 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain SapA PF02199.15 CDW58478.1 - 0.006 16.8 1.1 3.6 8.0 0.1 2.6 2 0 0 2 2 2 2 Saposin A-type domain DUF3568 PF12092.8 CDW58478.1 - 0.017 15.2 1.0 6 7.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3568) Astacin PF01400.24 CDW58483.1 - 1.3e-21 77.1 0.0 1.9e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Fimbrial_K88 PF02432.15 CDW58486.1 - 0.14 12.1 0.1 0.27 11.2 0.1 1.3 1 0 0 1 1 1 0 Fimbrial, major and minor subunit DUF2207 PF09972.9 CDW58487.1 - 7.7 5.1 7.7 5.3 5.7 6.1 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Reticulon PF02453.17 CDW58488.1 - 2.7e-07 30.7 7.2 3.8e-07 30.2 4.4 2.2 2 0 0 2 2 2 1 Reticulon PDZ PF00595.24 CDW58489.1 - 7.7e-20 71.0 0.1 2e-19 69.7 0.0 1.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 CDW58489.1 - 7.5e-07 28.9 0.0 1.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW58489.1 - 0.00053 20.3 0.0 0.00086 19.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DP PF08781.10 CDW58490.1 - 4.2e-31 107.7 0.1 8.6e-31 106.7 0.0 1.6 2 0 0 2 2 2 1 Transcription factor DP E2F_TDP PF02319.20 CDW58490.1 - 8.8e-26 89.8 0.5 2.3e-25 88.5 0.0 2.0 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain GcnA_N PF18229.1 CDW58490.1 - 0.00016 21.6 0.0 0.00059 19.8 0.0 1.9 2 0 0 2 2 2 1 N-acetyl-beta-D-glucosaminidase N-terminal domain Motile_Sperm PF00635.26 CDW58491.1 - 3.5e-09 36.5 0.0 5.8e-09 35.8 0.0 1.4 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Not3 PF04065.15 CDW58492.1 - 1.2e-60 204.8 22.1 8e-60 202.1 22.1 1.9 1 1 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 CDW58492.1 - 1.5e-36 125.4 8.3 1.5e-36 125.4 8.3 1.7 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family RNA_pol_Rpb1_6 PF04992.14 CDW58492.1 - 0.022 14.6 2.7 0.046 13.6 2.7 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 6 Poty_PP PF08440.10 CDW58492.1 - 0.06 12.4 1.9 0.098 11.7 1.9 1.3 1 0 0 1 1 1 0 Potyviridae polyprotein DUF2203 PF09969.9 CDW58492.1 - 0.86 10.3 6.2 0.39 11.5 1.5 2.4 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF5065 PF16723.5 CDW58492.1 - 1.2 9.2 6.1 7.9 6.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5065) Cbl_N3 PF02762.14 CDW58493.1 - 8.3e-46 153.8 0.0 1.3e-45 153.1 0.0 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N PF02262.16 CDW58493.1 - 2.7e-45 153.4 0.5 4.2e-45 152.8 0.5 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N2 PF02761.14 CDW58493.1 - 1.1e-38 131.8 1.3 2.8e-38 130.5 1.3 1.8 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.6 CDW58493.1 - 3.1e-12 46.2 9.1 9.7e-12 44.6 9.1 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CDW58493.1 - 1.5e-10 40.8 7.3 3.7e-10 39.5 7.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW58493.1 - 1.5e-09 37.6 7.4 3.6e-09 36.3 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW58493.1 - 3.9e-07 30.3 7.6 1.7e-06 28.3 7.6 2.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW58493.1 - 9.9e-05 22.1 9.6 0.00011 21.9 7.5 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW58493.1 - 0.00071 19.5 9.9 0.0017 18.4 8.7 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDW58493.1 - 0.0044 17.0 9.5 0.014 15.3 9.5 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDW58493.1 - 0.035 14.3 8.4 0.11 12.7 8.4 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CDW58493.1 - 0.075 12.8 8.9 0.21 11.4 8.6 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CDW58493.1 - 0.72 10.2 11.0 0.092 13.0 6.3 2.0 2 0 0 2 2 1 0 RING-H2 zinc finger domain Thioredoxin_6 PF13848.6 CDW58494.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Motile_Sperm PF00635.26 CDW58495.1 - 5.3e-16 58.4 0.0 7.6e-16 57.9 0.0 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain EloA-BP1 PF15870.5 CDW58496.1 - 1.3e-20 74.3 0.6 2.4e-20 73.5 0.0 1.7 2 0 0 2 2 2 1 ElonginA binding-protein 1 Radical_SAM PF04055.21 CDW58497.1 - 3.5e-13 50.3 0.0 5e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDW58497.1 - 5.9e-06 26.6 0.0 1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDW58497.1 - 0.0086 16.2 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain AA_permease PF00324.21 CDW58498.1 - 2.2e-103 346.4 54.5 2.8e-103 346.1 54.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CDW58498.1 - 1e-40 139.9 58.5 1.4e-40 139.5 58.5 1.0 1 0 0 1 1 1 1 Amino acid permease GDP_Man_Dehyd PF16363.5 CDW58499.1 - 4.7e-99 331.9 0.0 7.2e-99 331.3 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDW58499.1 - 4.8e-75 252.1 0.0 6.8e-75 251.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NTP_transferase PF00483.23 CDW58499.1 - 2.5e-30 105.8 0.1 3.9e-30 105.2 0.1 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Polysacc_synt_2 PF02719.15 CDW58499.1 - 4.3e-16 58.9 0.0 6.5e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CDW58499.1 - 1.7e-14 53.5 0.0 2.8e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CDW58499.1 - 2.7e-14 53.0 0.0 3.8e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CDW58499.1 - 6.4e-12 45.2 0.0 7.4e-08 31.9 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 CDW58499.1 - 0.00037 20.0 0.1 0.11 12.0 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 CDW58499.1 - 0.003 17.8 0.0 0.0055 17.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 CDW58499.1 - 0.011 15.6 0.0 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 KR domain Glyco_hydro_63N PF16923.5 CDW58499.1 - 0.075 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 N-terminal domain Wzz PF02706.15 CDW58500.1 - 6.6e-15 55.2 0.9 1.2e-14 54.3 0.0 1.9 2 0 0 2 2 2 1 Chain length determinant protein GNVR PF13807.6 CDW58500.1 - 0.011 15.6 0.3 0.13 12.2 0.0 2.5 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase Alpha-L-AF_C PF06964.12 CDW58500.1 - 0.14 12.3 1.1 3.2 7.9 1.1 2.2 1 1 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminal domain Glycos_transf_4 PF00953.21 CDW58501.1 - 9.2e-20 71.2 15.3 9.2e-20 71.2 15.3 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 4 FixP_N PF14715.6 CDW58501.1 - 2.1 8.2 7.0 0.15 11.8 0.7 2.4 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP DUF983 PF06170.12 CDW58501.1 - 8.9 6.8 15.9 2.9 8.4 1.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF983) Thioredoxin PF00085.20 CDW58502.1 - 1.6e-32 111.5 0.0 3.1e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Rho_RNA_bind PF07497.12 CDW58502.1 - 2.5e-32 110.6 0.0 5.1e-32 109.6 0.0 1.6 1 0 0 1 1 1 1 Rho termination factor, RNA-binding domain ATP-synt_ab PF00006.25 CDW58502.1 - 1.3e-22 80.5 0.0 2e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Rho_N PF07498.12 CDW58502.1 - 8.2e-18 64.1 0.9 6.3e-17 61.2 0.3 2.5 2 0 0 2 2 2 1 Rho termination factor, N-terminal domain Thioredoxin_2 PF13098.6 CDW58502.1 - 2.2e-06 28.1 0.0 1.5e-05 25.4 0.0 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDW58502.1 - 5.4e-05 23.5 0.0 0.0014 18.9 0.0 2.7 1 1 1 2 2 2 1 Thioredoxin-like NACHT PF05729.12 CDW58502.1 - 8.4e-05 22.5 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain TraF PF13728.6 CDW58502.1 - 0.0011 18.8 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 CDW58502.1 - 0.0018 18.1 0.0 0.0046 16.7 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin OB_RNB PF08206.11 CDW58502.1 - 0.003 17.2 0.0 0.0063 16.2 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease B OB domain AAA_25 PF13481.6 CDW58502.1 - 0.004 16.8 0.0 0.015 14.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 CDW58502.1 - 0.0054 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW58502.1 - 0.012 15.9 0.0 0.034 14.4 0.0 1.7 2 0 0 2 2 1 0 AAA domain AhpC-TSA PF00578.21 CDW58502.1 - 0.036 14.0 0.0 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 AhpC/TSA family Thioredoxin_3 PF13192.6 CDW58502.1 - 0.048 13.7 0.0 0.099 12.7 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin domain Redoxin PF08534.10 CDW58502.1 - 0.065 12.9 0.0 0.41 10.3 0.0 2.2 2 0 0 2 2 2 0 Redoxin OST3_OST6 PF04756.13 CDW58502.1 - 0.071 12.5 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CDW58502.1 - 0.082 13.1 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like Terminase_GpA PF05876.12 CDW58502.1 - 0.16 10.5 0.0 9.5 4.6 0.0 2.1 2 0 0 2 2 2 0 Phage terminase large subunit (GpA) DEAD PF00270.29 CDW58503.1 - 1.1e-45 155.5 0.0 2.2e-44 151.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW58503.1 - 5.4e-30 104.0 0.0 1.4e-28 99.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW58503.1 - 7.6e-06 26.0 0.0 1.3e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDW58503.1 - 0.0038 16.5 0.0 0.0054 16.0 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 CDW58503.1 - 0.024 14.9 0.1 0.087 13.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain Ppx-GppA PF02541.16 CDW58504.1 - 1e-103 346.7 0.7 1.6e-103 346.1 0.7 1.3 1 0 0 1 1 1 1 Ppx/GppA phosphatase family DDR PF08841.10 CDW58504.1 - 0.075 12.0 0.2 0.13 11.3 0.2 1.4 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain DUF150 PF02576.17 CDW58504.1 - 0.099 13.1 0.1 0.7 10.3 0.0 2.1 2 0 0 2 2 2 0 RimP N-terminal domain DUF4049 PF13258.6 CDW58504.1 - 0.21 10.6 0.0 0.34 9.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4049) UvrD-helicase PF00580.21 CDW58505.1 - 1.9e-73 247.7 0.3 2.9e-72 243.9 0.3 2.2 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CDW58505.1 - 2.3e-71 241.0 0.1 8.3e-71 239.2 0.1 1.8 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CDW58505.1 - 3.9e-36 124.6 0.0 7.5e-36 123.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CDW58505.1 - 2e-10 40.3 0.0 7.7e-10 38.4 0.0 2.0 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CDW58505.1 - 6.6e-10 39.0 0.2 2.5e-05 24.1 0.2 2.6 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CDW58505.1 - 6.2e-06 26.1 0.2 0.12 12.1 0.0 3.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Exonuc_V_gamma PF04257.14 CDW58505.1 - 0.0018 16.6 0.1 0.0049 15.2 0.1 1.7 1 0 0 1 1 1 1 Exodeoxyribonuclease V, gamma subunit Rotamase_3 PF13616.6 CDW58506.1 - 1.4e-20 74.0 0.0 1.6e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 CDW58506.1 - 4.8e-20 72.3 0.0 6.8e-20 71.8 0.0 1.2 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 CDW58506.1 - 0.00015 22.6 0.0 0.00016 22.5 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain IlvN PF07991.12 CDW58507.1 - 9.4e-59 197.7 0.2 1.5e-58 197.0 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CDW58507.1 - 1e-52 178.3 0.2 1.3e-28 100.1 0.0 2.3 2 0 0 2 2 2 2 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 CDW58507.1 - 0.00067 19.1 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CDW58507.1 - 0.005 17.3 0.0 0.015 15.7 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding ApbA PF02558.16 CDW58507.1 - 0.0093 15.6 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AdoHcyase_NAD PF00670.21 CDW58507.1 - 0.03 14.4 0.0 0.063 13.3 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain LysR_substrate PF03466.20 CDW58508.1 - 2.3e-37 128.4 0.1 3e-37 128.0 0.1 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDW58508.1 - 3.3e-13 49.4 0.1 6e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family SBP_bac_11 PF13531.6 CDW58508.1 - 0.093 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein HTH_24 PF13412.6 CDW58508.1 - 0.12 12.0 0.3 0.34 10.5 0.0 2.0 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding PALP PF00291.25 CDW58509.1 - 1.1e-74 251.6 2.2 1.5e-74 251.1 2.2 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 CDW58509.1 - 1e-58 195.1 0.0 2.7e-29 100.8 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase ILVD_EDD PF00920.21 CDW58510.1 - 3.4e-220 732.0 1.9 3.9e-220 731.9 1.9 1.0 1 0 0 1 1 1 1 Dehydratase family Ribosomal_S27 PF01599.19 CDW58510.1 - 0.82 9.9 4.0 28 5.0 0.8 3.1 3 0 0 3 3 3 0 Ribosomal protein S27a Aminotran_4 PF01063.19 CDW58511.1 - 5.6e-51 173.5 0.0 6.6e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV G-gamma PF00631.22 CDW58511.1 - 0.19 11.8 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 GGL domain TPP_enzyme_N PF02776.18 CDW58512.1 - 1.5e-57 193.9 2.2 3.1e-56 189.7 0.1 3.4 4 1 0 4 4 4 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CDW58512.1 - 1.1e-51 174.6 0.4 3.2e-50 169.9 0.0 2.8 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CDW58512.1 - 1.5e-44 151.1 0.1 3e-44 150.1 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 CDW58512.1 - 0.0036 17.1 0.3 0.0067 16.2 0.3 1.4 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg XFP_N PF09364.10 CDW58512.1 - 0.083 11.7 0.1 0.21 10.3 0.1 1.6 1 1 0 1 1 1 0 XFP N-terminal domain Mg_chelatase PF01078.21 CDW58513.1 - 6.6e-90 300.0 0.0 1.1e-89 299.3 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ChlI PF13541.6 CDW58513.1 - 1.7e-44 150.5 0.1 2.5e-44 150.0 0.1 1.2 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 CDW58513.1 - 6.3e-13 48.9 0.0 1.1e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 CDW58513.1 - 1.2e-12 47.4 0.0 1.8e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 MCM P-loop domain Sigma54_activat PF00158.26 CDW58513.1 - 4.2e-06 26.6 0.0 3.1e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 CDW58513.1 - 9.4e-05 22.9 0.2 0.00037 20.9 0.1 2.1 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW58513.1 - 0.0025 18.2 0.0 0.02 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CDW58513.1 - 0.0028 17.4 0.1 0.073 12.8 0.0 2.6 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CDW58513.1 - 0.0036 17.6 0.0 0.0087 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CDW58513.1 - 0.0042 16.6 0.0 0.031 13.8 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 CDW58513.1 - 0.025 14.3 0.1 0.047 13.4 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 CDW58513.1 - 0.029 14.5 0.0 2.9 8.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.15 CDW58513.1 - 0.037 14.0 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CDW58513.1 - 0.041 14.2 0.0 0.086 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW58513.1 - 0.044 13.5 0.0 0.07 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDW58513.1 - 0.045 14.3 0.0 0.095 13.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_3 PF07726.11 CDW58513.1 - 0.076 12.9 0.0 8.2 6.3 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_32 PF13654.6 CDW58513.1 - 0.093 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDW58513.1 - 0.094 12.9 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDW58513.1 - 0.095 12.4 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CDW58513.1 - 0.12 12.3 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 CDW58513.1 - 0.13 11.4 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CDW58513.1 - 0.16 11.6 0.1 0.31 10.6 0.1 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 CDW58513.1 - 0.22 10.9 0.0 0.39 10.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DUF413 PF04219.12 CDW58514.1 - 6e-39 132.0 0.1 7.1e-39 131.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF LysR_substrate PF03466.20 CDW58515.1 - 1.1e-14 54.3 0.0 3.8e-14 52.5 0.0 1.7 1 1 0 1 1 1 1 LysR substrate binding domain WD40 PF00400.32 CDW58516.1 - 2.4e-09 37.7 9.3 0.098 13.6 0.0 7.5 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW58516.1 - 5.5e-09 36.2 0.3 0.065 13.5 0.0 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW58516.1 - 0.0066 16.3 0.0 0.5 10.2 0.0 3.2 2 2 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 CDW58516.1 - 0.0072 15.4 2.5 0.56 9.2 0.9 3.3 2 1 1 3 3 3 2 Coatomer WD associated region VID27 PF08553.10 CDW58516.1 - 0.015 14.4 0.0 3.3 6.7 0.1 2.5 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain YpsA PF06908.11 CDW58516.1 - 0.019 15.0 0.0 0.073 13.1 0.0 1.9 2 0 0 2 2 2 0 YspA SLOG family Virulence_fact PF13769.6 CDW58516.1 - 0.021 15.1 0.0 2.6 8.3 0.0 2.6 2 0 0 2 2 2 0 Virulence factor IKI3 PF04762.12 CDW58516.1 - 0.069 11.1 0.0 2.3 6.1 0.0 2.4 2 0 0 2 2 2 0 IKI3 family PD40 PF07676.12 CDW58516.1 - 0.14 12.2 0.2 11 6.1 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat P21-Arc PF04062.14 CDW58517.1 - 1.3e-56 191.3 0.2 7.2e-33 114.1 0.0 2.0 1 1 1 2 2 2 2 ARP2/3 complex ARPC3 (21 kDa) subunit PaaX_C PF08223.11 CDW58518.1 - 0.08 13.2 0.2 11 6.4 0.0 2.6 2 0 0 2 2 2 0 PaaX-like protein C-terminal domain B9-C2 PF07162.11 CDW58519.1 - 2.6e-27 96.1 0.0 4e-27 95.5 0.0 1.2 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein ERM PF00769.19 CDW58520.1 - 1.2e-63 215.2 52.8 1.2e-63 215.2 52.8 2.1 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.10 CDW58520.1 - 1.8e-27 95.5 0.0 3.9e-27 94.5 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 CDW58520.1 - 1.2e-18 67.7 0.2 1.2e-18 67.7 0.2 3.7 3 1 0 4 4 4 1 FERM central domain PET10 PF17316.2 CDW58520.1 - 0.015 14.9 2.5 0.039 13.5 2.5 1.7 1 0 0 1 1 1 0 Petite colonies protein 10 XhlA PF10779.9 CDW58520.1 - 0.021 15.0 3.8 0.021 15.0 3.8 4.0 2 1 1 3 3 3 0 Haemolysin XhlA NPV_P10 PF05531.12 CDW58520.1 - 0.25 11.8 7.6 17 6.0 0.1 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 CDW58520.1 - 8.1 6.9 21.1 2.4 8.6 4.0 4.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Peptidase_C14 PF00656.22 CDW58521.1 - 1.4e-09 38.3 0.0 6.1e-08 32.9 0.0 2.8 1 1 0 1 1 1 1 Caspase domain Ig_3 PF13927.6 CDW58521.1 - 4.7e-07 30.3 0.1 1.2e-06 29.0 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 CDW58521.1 - 0.00038 20.7 0.1 0.00087 19.6 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain MALT1_Ig PF18703.1 CDW58521.1 - 0.041 13.9 0.0 0.095 12.7 0.0 1.7 1 0 0 1 1 1 0 MALT1 Ig-like domain Ion_trans PF00520.31 CDW58522.1 - 1.5e-46 158.6 14.0 2.2e-46 158.1 14.0 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 CDW58522.1 - 6.7e-27 93.7 0.0 1.9e-26 92.3 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 CDW58522.1 - 9.3e-10 38.3 4.2 9.3e-10 38.3 4.2 2.4 2 0 0 2 2 2 1 Ion channel PKD_channel PF08016.12 CDW58522.1 - 0.026 13.2 8.1 0.015 14.0 1.9 2.2 1 1 1 2 2 2 0 Polycystin cation channel RNA_pol_Rpb2_6 PF00562.28 CDW58523.1 - 1.6e-121 406.0 0.0 2.2e-121 405.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CDW58523.1 - 3.1e-46 157.4 0.0 5.7e-46 156.6 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_4 PF04566.13 CDW58523.1 - 2e-21 76.0 0.8 4.2e-21 75.0 0.8 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 CDW58523.1 - 2.2e-19 69.4 0.0 4.6e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 CDW58523.1 - 6.4e-16 58.5 0.1 1.5e-15 57.3 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CDW58523.1 - 2.7e-15 56.5 0.1 6.2e-15 55.4 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_5 PF04567.17 CDW58523.1 - 9.1e-10 39.0 1.3 2.9e-09 37.4 1.3 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Homeodomain PF00046.29 CDW58524.1 - 2.3e-13 49.8 0.4 4e-13 49.0 0.4 1.4 1 0 0 1 1 1 1 Homeodomain Las1 PF04031.13 CDW58524.1 - 0.012 15.7 0.1 0.025 14.7 0.1 1.5 1 1 0 1 1 1 0 Las1-like Homeodomain PF00046.29 CDW58525.1 - 0.0028 17.4 5.6 0.006 16.4 5.6 1.5 1 0 0 1 1 1 1 Homeodomain eIF3_subunit PF08597.10 CDW58526.1 - 2.6e-26 93.0 21.6 6.1e-26 91.8 21.6 1.5 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit HTH_19 PF12844.7 CDW58526.1 - 0.066 13.2 2.6 1.3 9.1 0.2 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain DNA_repr_REX1B PF14966.6 CDW58526.1 - 0.097 13.3 1.7 0.23 12.2 0.2 2.3 1 1 2 3 3 3 0 DNA repair REX1-B DUF3347 PF11827.8 CDW58526.1 - 0.11 12.7 5.5 0.054 13.7 2.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) UNC-93 PF05978.16 CDW58527.1 - 6.7e-40 136.4 12.7 6.7e-40 136.4 12.7 4.1 4 1 1 5 5 5 2 Ion channel regulatory protein UNC-93 Tom22 PF04281.13 CDW58527.1 - 5.9e-07 29.4 0.0 1.3e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 DC_STAMP PF07782.13 CDW58528.1 - 6.9e-22 78.2 2.4 2.6e-18 66.5 0.1 2.6 1 1 1 2 2 2 2 DC-STAMP-like protein Xpo1 PF08389.12 CDW58529.1 - 1.1e-07 32.1 1.5 4.2e-06 26.9 0.1 2.9 2 0 0 2 2 2 1 Exportin 1-like protein DUF3549 PF12069.8 CDW58529.1 - 0.029 13.4 0.6 0.12 11.4 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3549) Importin_rep PF18773.1 CDW58529.1 - 0.095 12.4 0.1 0.24 11.1 0.1 1.7 1 0 0 1 1 1 0 Importin 13 repeat Motile_Sperm PF00635.26 CDW58530.1 - 1.8e-05 24.6 0.0 3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Peptidase_M16_C PF05193.21 CDW58531.1 - 1.7e-10 41.2 0.0 2e-08 34.5 0.0 2.4 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDW58531.1 - 3e-09 37.0 0.0 4.5e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) RRM_1 PF00076.22 CDW58532.1 - 5.6e-16 58.1 0.1 8.3e-16 57.6 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW58532.1 - 0.0053 16.4 0.0 0.0087 15.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_4 PF14392.6 CDW58532.1 - 0.013 15.2 0.7 0.025 14.3 0.7 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC PF00098.23 CDW58532.1 - 0.024 14.7 2.2 0.024 14.7 2.2 1.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 CDW58532.1 - 0.069 13.1 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle RRM_3 PF08777.11 CDW58532.1 - 0.18 11.9 0.1 0.25 11.4 0.1 1.2 1 0 0 1 1 1 0 RNA binding motif FH2 PF02181.23 CDW58533.1 - 2.5e-85 286.8 12.3 2.5e-85 286.8 12.3 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 CDW58533.1 - 2.6e-39 134.9 1.0 2.6e-39 134.9 1.0 3.1 4 0 0 4 4 4 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 CDW58533.1 - 3.1e-38 131.2 0.4 3.1e-38 131.2 0.4 2.6 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_DAD PF06345.11 CDW58533.1 - 1.5e-06 27.8 3.2 2e-06 27.4 1.1 2.4 2 0 0 2 2 2 1 DRF Autoregulatory Domain Act-Frag_cataly PF09192.10 CDW58533.1 - 0.027 13.8 5.1 0.07 12.5 0.8 2.4 2 0 0 2 2 2 0 Actin-fragmin kinase, catalytic DUF4994 PF16385.5 CDW58533.1 - 0.057 13.3 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function YabA PF06156.13 CDW58533.1 - 0.12 13.0 14.0 4.4 8.0 0.0 4.4 4 0 0 4 4 4 0 Initiation control protein YabA DZF PF07528.14 CDW58534.1 - 5.7e-51 173.5 0.0 9.2e-51 172.8 0.0 1.3 1 0 0 1 1 1 1 DZF domain TBP PF00352.21 CDW58535.1 - 1.3e-65 217.3 0.1 3.6e-32 110.2 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CDW58535.1 - 5.9e-05 23.1 0.0 0.11 12.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) RAI16-like PF10257.9 CDW58536.1 - 3.2e-47 161.1 5.2 5e-47 160.5 5.2 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Rep_fac-A_3 PF08661.11 CDW58536.1 - 4.8e-06 26.9 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Replication factor A protein 3 UbiA PF01040.18 CDW58537.1 - 7.4e-54 182.7 13.1 9.6e-54 182.3 13.1 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Amastin PF07344.11 CDW58537.1 - 0.018 14.9 3.1 0.074 12.9 1.2 2.3 1 1 1 2 2 2 0 Amastin surface glycoprotein AAT PF03417.16 CDW58538.1 - 0.2 11.3 0.0 0.28 10.8 0.0 1.3 1 1 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase CAP PF00188.26 CDW58539.1 - 4.1e-07 30.9 1.6 9.1e-07 29.8 1.6 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family AAA_15 PF13175.6 CDW58539.1 - 0.00018 21.4 20.7 0.00022 21.0 20.7 1.2 1 0 0 1 1 1 1 AAA ATPase domain SDA1 PF05285.12 CDW58539.1 - 0.01 15.3 46.3 0.015 14.8 46.3 1.3 1 0 0 1 1 1 0 SDA1 SLC12 PF03522.15 CDW58539.1 - 0.034 13.2 19.1 0.049 12.6 19.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 BUD22 PF09073.10 CDW58539.1 - 0.24 10.7 45.6 0.35 10.2 45.6 1.3 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 CDW58539.1 - 0.39 9.4 18.3 0.54 9.0 18.3 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 CDW58539.1 - 0.66 8.1 47.0 0.91 7.7 47.0 1.1 1 0 0 1 1 1 0 Nop14-like family AAA_11 PF13086.6 CDW58539.1 - 3.1 7.5 13.6 5.4 6.7 13.6 1.3 1 0 0 1 1 1 0 AAA domain CoA_binding PF02629.19 CDW58541.1 - 1.4e-31 109.0 0.2 4.3e-31 107.5 0.2 1.9 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 CDW58541.1 - 8.6e-24 84.1 0.7 1.7e-23 83.1 0.1 1.7 2 0 0 2 2 2 1 CoA-ligase Succ_CoA_lig PF13607.6 CDW58541.1 - 7.6e-09 35.5 0.0 1.5e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CDW58541.1 - 0.00014 22.3 0.0 0.0017 18.8 0.0 2.6 3 0 0 3 3 3 1 CoA binding domain 2-Hacid_dh PF00389.30 CDW58541.1 - 0.045 13.4 0.5 3.6 7.3 0.0 2.5 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Glyco_trans_1_4 PF13692.6 CDW58541.1 - 0.094 13.1 0.1 0.28 11.6 0.1 1.8 2 0 0 2 2 2 0 Glycosyl transferases group 1 IF4E PF01652.18 CDW58542.1 - 5.5e-46 156.3 0.6 6.7e-46 156.0 0.6 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E EGF PF00008.27 CDW58543.1 - 1.4e-16 60.4 85.1 2.9e-08 33.9 6.2 7.3 8 0 0 8 8 8 6 EGF-like domain hEGF PF12661.7 CDW58543.1 - 3.7e-09 36.9 78.3 5.2e-05 23.7 7.4 8.2 8 0 0 8 8 8 5 Human growth factor-like EGF EGF_2 PF07974.13 CDW58543.1 - 8.1e-07 29.3 93.4 0.0035 17.7 10.5 7.0 7 0 0 7 7 7 5 EGF-like domain EGF_CA PF07645.15 CDW58543.1 - 1.8e-06 28.0 9.2 1.8e-06 28.0 9.2 6.9 1 1 5 6 6 6 1 Calcium-binding EGF domain EGF_3 PF12947.7 CDW58543.1 - 0.052 13.8 70.7 0.037 14.2 1.4 7.3 4 2 2 6 6 6 0 EGF domain SpoIIIAH PF12685.7 CDW58543.1 - 0.063 13.1 0.1 0.063 13.1 0.1 2.0 1 1 0 2 2 2 0 SpoIIIAH-like protein Laminin_EGF PF00053.24 CDW58543.1 - 2 8.7 69.3 6.6 7.0 7.5 6.8 2 2 4 6 6 6 0 Laminin EGF domain Amidohydro_1 PF01979.20 CDW58544.1 - 2.6e-16 59.9 0.0 1.7e-15 57.2 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CDW58544.1 - 0.0002 21.0 0.0 0.00041 19.9 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family FliG_N PF14842.6 CDW58545.1 - 8.8e-06 26.2 0.0 1.3 9.6 0.0 4.3 4 0 0 4 4 4 2 FliG N-terminal domain Bac_rhamnosid_C PF17390.2 CDW58545.1 - 2e-05 24.3 1.1 2.8 7.8 0.0 3.7 3 0 0 3 3 3 3 Bacterial alpha-L-rhamnosidase C-terminal domain RACo_linker PF17650.1 CDW58545.1 - 0.0006 19.6 0.1 4.8 7.1 0.0 3.5 3 0 0 3 3 3 2 RACo linker region Y_phosphatase2 PF03162.13 CDW58545.1 - 0.0045 16.6 0.0 27 4.3 0.0 3.5 3 0 0 3 3 3 0 Tyrosine phosphatase family RestrictionMunI PF11407.8 CDW58545.1 - 0.0099 15.6 0.0 36 4.0 0.0 3.3 3 0 0 3 3 3 0 Type II restriction enzyme MunI DDE_Tnp_IS66_C PF13817.6 CDW58545.1 - 0.025 14.8 0.5 35 4.7 0.0 3.5 3 0 0 3 3 3 0 IS66 C-terminal element Spore_YpjB PF09577.10 CDW58545.1 - 0.032 14.0 6.8 14 5.4 0.3 4.2 4 0 0 4 4 4 0 Sporulation protein YpjB (SpoYpjB) ETC_C1_NDUFA5 PF04716.14 CDW58545.1 - 0.053 13.3 0.3 24 4.8 0.0 3.2 3 0 0 3 3 3 0 ETC complex I subunit conserved region FtsK_SpoIIIE_N PF12538.8 CDW58545.1 - 0.058 13.6 1.4 8.9 6.5 0.1 3.2 3 0 0 3 3 3 0 DNA transporter JmjC PF02373.22 CDW58545.1 - 0.12 12.8 0.4 51 4.3 0.0 3.4 3 0 0 3 3 3 0 JmjC domain, hydroxylase YmgD PF16456.5 CDW58545.1 - 0.14 12.3 0.0 35 4.5 0.0 2.9 2 0 0 2 2 2 0 YmgD protein WHAMM-JMY_N PF15920.5 CDW58545.1 - 0.17 11.7 0.7 1.1e+02 2.8 0.0 3.4 3 0 0 3 3 3 0 N-terminal of Junction-mediating and WASP homolog-associated TMF_TATA_bd PF12325.8 CDW58545.1 - 0.37 11.0 9.6 25 5.1 0.5 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Casein PF00363.18 CDW58545.1 - 0.37 11.2 1.7 56 4.2 0.1 3.3 2 0 0 2 2 2 0 Casein SAP PF02037.27 CDW58545.1 - 0.49 10.2 1.8 82 3.1 0.1 3.6 3 0 0 3 3 3 0 SAP domain Oscp1 PF10188.9 CDW58545.1 - 0.96 9.5 4.6 32 4.6 0.1 3.6 4 0 0 4 4 4 0 Organic solute transport protein 1 Adaptin_N PF01602.20 CDW58546.1 - 2.1e-143 478.7 5.6 2.5e-143 478.4 5.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 CDW58546.1 - 2.4e-19 69.6 2.8 1.5e-15 57.3 0.1 2.9 2 1 1 3 3 3 2 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 CDW58546.1 - 5.2e-15 55.7 0.1 1.2e-14 54.5 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.6 CDW58546.1 - 5e-06 26.8 1.0 0.033 14.6 0.0 4.1 4 0 0 4 4 4 1 HEAT repeats Cnd1 PF12717.7 CDW58546.1 - 3.1e-05 24.1 0.5 0.0069 16.4 0.0 3.5 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 CDW58546.1 - 0.0048 16.0 0.8 0.013 14.6 0.8 1.7 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) DUF4003 PF13170.6 CDW58546.1 - 0.0076 15.7 2.0 0.023 14.1 0.4 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF4003) Claudin_2 PF13903.6 CDW58547.1 - 2.2e-25 89.6 0.7 3.6e-25 88.9 0.7 1.3 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 CDW58547.1 - 0.02 14.8 10.7 9.7 6.0 10.2 3.2 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF2542 PF10808.8 CDW58547.1 - 0.12 12.8 1.9 0.14 12.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2542) DUF1772 PF08592.11 CDW58547.1 - 0.15 12.3 0.9 0.62 10.4 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) Herpes_UL73 PF03554.13 CDW58547.1 - 4 7.5 8.5 0.22 11.6 2.0 2.2 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein 5_nucleotid PF05761.14 CDW58548.1 - 7.6e-163 542.6 0.0 1.4e-162 541.8 0.0 1.4 1 1 0 1 1 1 1 5' nucleotidase family C1_1 PF00130.22 CDW58553.1 - 1.6e-36 124.0 22.3 2.8e-18 65.5 9.9 2.8 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.30 CDW58553.1 - 4.3e-26 91.2 0.0 8.1e-26 90.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain C1_2 PF03107.16 CDW58553.1 - 0.0017 18.6 12.9 0.12 12.8 2.6 2.7 2 0 0 2 2 2 2 C1 domain Zf_RING PF16744.5 CDW58553.1 - 0.011 15.9 11.6 0.016 15.3 2.0 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger PHD PF00628.29 CDW58553.1 - 0.067 13.1 18.2 0.85 9.6 5.7 2.7 2 0 0 2 2 2 0 PHD-finger zf-RING_9 PF13901.6 CDW58553.1 - 0.079 12.9 15.4 0.69 9.9 2.5 2.4 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon RNA_POL_M_15KD PF02150.16 CDW58553.1 - 0.21 11.5 11.0 1.4 8.8 0.7 2.9 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit PHD_4 PF16866.5 CDW58553.1 - 0.97 9.6 11.9 1.3 9.1 0.6 3.1 2 1 0 2 2 2 0 PHD-finger zf-RING-like PF08746.11 CDW58553.1 - 4.5 7.6 21.3 1.1 9.6 6.2 2.8 2 0 0 2 2 2 0 RING-like domain Zn_ribbon_17 PF17120.5 CDW58553.1 - 6.1 6.6 14.1 7.5 6.3 1.4 2.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type PHD_2 PF13831.6 CDW58553.1 - 8.8 6.0 21.7 0.1 12.2 1.3 3.5 4 0 0 4 4 4 0 PHD-finger DUF1801 PF08818.11 CDW58556.1 - 0.089 13.3 0.1 1.5 9.4 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DU1801) CUB PF00431.20 CDW58557.1 - 4.4e-33 113.9 0.7 1.9e-17 63.6 0.0 2.8 2 1 0 2 2 2 2 CUB domain Ldl_recept_a PF00057.18 CDW58557.1 - 0.00032 20.9 3.0 0.00032 20.9 3.0 3.2 2 1 1 3 3 3 2 Low-density lipoprotein receptor domain class A YEATS PF03366.16 CDW58558.1 - 1.3e-22 79.6 0.2 1.8e-22 79.1 0.2 1.2 1 0 0 1 1 1 1 YEATS family AHD PF17793.1 CDW58559.1 - 5.1e-12 45.4 0.1 8.7e-12 44.7 0.1 1.3 1 0 0 1 1 1 1 ANC1 homology domain (AHD) MLTR_LBD PF17765.1 CDW58559.1 - 0.041 14.0 0.0 0.067 13.3 0.0 1.2 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain Macoilin PF09726.9 CDW58559.1 - 0.046 12.3 11.8 0.055 12.0 11.8 1.1 1 0 0 1 1 1 0 Macoilin family Evr1_Alr PF04777.13 CDW58560.1 - 0.14 12.6 0.1 0.64 10.5 0.0 2.1 2 0 0 2 2 2 0 Erv1 / Alr family RNA_pol_Rpb1_2 PF00623.20 CDW58561.1 - 7.9e-61 205.1 0.0 1.4e-60 204.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_1 PF04997.12 CDW58561.1 - 1.1e-17 64.3 3.4 1.2e-15 57.7 3.4 3.2 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 1 zf-C2HE PF16278.5 CDW58561.1 - 0.37 11.3 2.2 0.88 10.1 0.0 2.6 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger RNA_pol_Rpb1_5 PF04998.17 CDW58562.1 - 5.7e-08 32.5 0.0 7.1e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 ORC6 PF05460.13 CDW58562.1 - 0.22 10.8 0.1 0.3 10.3 0.1 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Kringle PF00051.18 CDW58563.1 - 1.8e-21 76.2 32.7 1.2e-11 44.7 7.9 5.4 5 0 0 5 5 5 3 Kringle domain DUF4500 PF14937.6 CDW58563.1 - 0.14 12.2 0.0 0.46 10.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) zf-CCCH PF00642.24 CDW58564.1 - 1.4e-06 28.0 20.8 0.00025 20.9 1.6 3.3 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CDW58564.1 - 1.3e-05 25.9 12.9 0.11 13.1 0.2 3.3 1 1 2 3 3 3 3 Torus domain zf-CCCH_4 PF18044.1 CDW58564.1 - 0.00026 20.7 3.2 0.00026 20.7 3.2 3.2 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CDW58564.1 - 0.00046 20.6 22.0 0.019 15.5 3.6 3.3 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger YabA PF06156.13 CDW58564.1 - 0.0018 18.9 0.2 0.0039 17.8 0.2 1.6 1 0 0 1 1 1 1 Initiation control protein YabA TSC22 PF01166.18 CDW58564.1 - 0.0095 16.2 0.1 0.019 15.3 0.1 1.5 1 0 0 1 1 1 1 TSC-22/dip/bun family DUF4686 PF15742.5 CDW58564.1 - 0.025 13.7 0.2 0.038 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) zf_CCCH_4 PF18345.1 CDW58564.1 - 0.025 14.6 3.9 0.025 14.6 3.9 3.9 3 1 0 3 3 3 0 Zinc finger domain ZapB PF06005.12 CDW58564.1 - 0.081 13.4 0.4 0.17 12.4 0.4 1.4 1 0 0 1 1 1 0 Cell division protein ZapB STELLO PF03385.17 CDW58564.1 - 0.14 10.9 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 STELLO glycosyltransferases HALZ PF02183.18 CDW58564.1 - 0.2 11.9 0.4 0.47 10.7 0.4 1.6 1 1 0 1 1 1 0 Homeobox associated leucine zipper zf-CCCH_3 PF15663.5 CDW58564.1 - 1.3 9.3 9.9 22 5.3 0.0 2.5 2 1 0 2 2 2 0 Zinc-finger containing family Guanylate_cyc PF00211.20 CDW58565.1 - 8.6e-45 152.6 0.0 1.3e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.14 CDW58565.1 - 0.0049 17.4 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) SET PF00856.28 CDW58566.1 - 6.6e-10 39.6 0.0 2e-09 38.0 0.0 1.8 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 CDW58566.1 - 0.011 16.5 0.3 0.019 15.7 0.3 1.4 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding TUDOR PF00567.24 CDW58567.1 - 5.1e-09 36.2 0.0 1.2e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Tudor domain OST-HTH PF12872.7 CDW58567.1 - 2.9e-05 23.8 0.0 8.1e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Connexin40_C PF16791.5 CDW58567.1 - 0.82 11.0 4.9 2.3 9.5 0.3 3.1 2 1 1 3 3 3 0 Connexin 40 C-terminal domain Ribosomal_L3 PF00297.22 CDW58568.1 - 9.6e-183 607.2 11.7 1.1e-182 607.0 11.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 TIL PF01826.17 CDW58569.1 - 9.4e-15 54.6 14.6 9.4e-15 54.6 14.6 2.3 1 1 1 2 2 2 1 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 CDW58569.1 - 0.049 13.6 1.0 0.049 13.6 1.0 3.4 3 1 0 3 3 3 0 Complement Clr-like EGF-like TIL PF01826.17 CDW58571.1 - 6.4e-16 58.4 18.2 8e-16 58.0 18.2 1.1 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain cEGF PF12662.7 CDW58571.1 - 0.0075 16.2 2.6 0.0075 16.2 2.6 2.7 2 2 0 2 2 2 1 Complement Clr-like EGF-like CTP_synth_N PF06418.14 CDW58572.1 - 1.1e-121 405.2 0.0 1.5e-121 404.7 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CDW58572.1 - 6e-53 179.4 0.0 9.4e-53 178.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDW58572.1 - 2.4e-07 30.7 0.0 2.8e-06 27.2 0.0 2.3 2 0 0 2 2 2 1 Peptidase C26 CbiA PF01656.23 CDW58572.1 - 0.0061 16.6 0.0 0.011 15.7 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Brix PF04427.18 CDW58573.1 - 9.3e-19 68.3 0.1 1.3e-18 67.9 0.1 1.2 1 0 0 1 1 1 1 Brix domain DUF4560 PF15118.6 CDW58574.1 - 0.037 13.9 0.3 0.051 13.5 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4560) DUF5441 PF17513.2 CDW58575.1 - 0.051 13.3 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5441) POP1 PF06978.11 CDW58579.1 - 1.2e-26 93.9 28.0 8.6e-18 65.1 6.8 2.9 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 CDW58579.1 - 2.6e-22 79.0 2.7 2.6e-22 78.9 0.1 2.3 2 0 0 2 2 2 1 POPLD (NUC188) domain zf-C3Hc3H PF13891.6 CDW58580.1 - 3e-16 59.5 29.4 5.5e-13 49.1 5.2 3.4 4 0 0 4 4 4 2 Potential DNA-binding domain WRC PF08879.10 CDW58580.1 - 0.47 10.2 11.2 1.3 8.7 0.2 3.2 3 0 0 3 3 3 0 WRC FCH PF00611.23 CDW58581.1 - 1.6e-16 60.3 0.5 1.6e-16 60.3 0.5 2.6 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 CDW58581.1 - 2.1e-15 56.0 0.5 2.1e-15 56.0 0.5 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CDW58581.1 - 6.2e-14 51.6 0.3 1.3e-13 50.6 0.3 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CDW58581.1 - 1.4e-07 31.1 0.0 2.9e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Ferritin_2 PF13668.6 CDW58581.1 - 0.12 12.6 0.1 0.34 11.1 0.1 1.7 1 0 0 1 1 1 0 Ferritin-like domain RmuC PF02646.16 CDW58581.1 - 0.21 10.7 8.4 0.41 9.7 1.2 2.4 1 1 1 2 2 2 0 RmuC family Ig_3 PF13927.6 CDW58582.1 - 2.2e-21 76.2 0.1 1.5e-11 44.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 CDW58582.1 - 8.9e-19 67.6 0.1 9.8e-11 41.8 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain I-set PF07679.16 CDW58582.1 - 1.6e-17 63.4 0.0 2.8e-11 43.3 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin I-set domain ig PF00047.25 CDW58582.1 - 2.8e-17 62.7 0.0 3.3e-09 36.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 CDW58582.1 - 2.5e-08 34.1 0.8 0.63 10.2 0.0 4.5 3 1 0 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 CDW58582.1 - 0.00028 20.9 0.2 0.0019 18.2 0.0 2.3 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 CDW58582.1 - 0.005 17.1 0.0 4.8 7.5 0.0 3.4 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 CDW58582.1 - 0.015 14.8 0.0 3.6 7.2 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin domain CcmD PF04995.14 CDW58582.1 - 0.15 12.1 2.2 0.36 10.9 2.2 1.7 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) VWA_2 PF13519.6 CDW58583.1 - 2e-16 60.6 0.0 4.6e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain INT_SG_DDX_CT_C PF15300.6 CDW58583.1 - 2.5e-10 40.0 0.1 5.9e-10 38.8 0.1 1.6 1 0 0 1 1 1 1 INTS6/SAGE1/DDX26B/CT45 C-terminus VWA PF00092.28 CDW58583.1 - 0.00061 20.1 0.0 0.0012 19.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain RhoGEF PF00621.20 CDW58584.1 - 5.8e-28 98.4 0.1 1.2e-27 97.4 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 CDW58584.1 - 1.6e-07 31.8 0.0 1.1e-06 29.1 0.0 2.3 3 0 0 3 3 3 1 PH domain PH_10 PF15411.6 CDW58584.1 - 0.0021 18.3 0.9 0.02 15.1 0.9 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain zf-RING_9 PF13901.6 CDW58585.1 - 1.1e-50 172.5 11.7 9.4e-50 169.5 11.7 2.3 1 1 0 1 1 1 1 Putative zinc-RING and/or ribbon RUN PF02759.19 CDW58585.1 - 0.00039 20.4 1.1 0.0023 17.9 1.1 2.0 1 1 0 1 1 1 1 RUN domain RabGAP-TBC PF00566.18 CDW58586.1 - 3e-22 79.3 1.5 4e-22 78.9 1.5 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF5641 PF18701.1 CDW58587.1 - 7.9e-08 32.4 0.0 1.3e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) PP2C PF00481.21 CDW58588.1 - 6.4e-65 219.3 0.2 9.5e-52 176.2 0.2 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CDW58588.1 - 8e-06 25.6 0.1 0.016 14.9 0.0 3.0 2 1 0 2 2 2 2 Protein phosphatase 2C APG6 PF04111.12 CDW58589.1 - 3e-62 209.7 0.0 9.4e-62 208.1 0.0 1.8 2 0 0 2 2 2 1 Apg6 BARA domain APG6_N PF17675.1 CDW58589.1 - 2.8e-18 66.8 18.7 4.3e-18 66.1 18.7 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region DIT1_PvcA PF05141.12 CDW58589.1 - 0.0051 16.3 3.0 0.0076 15.7 3.0 1.2 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein NADH_dh_m_C1 PF15088.6 CDW58589.1 - 0.12 12.0 0.6 0.71 9.5 0.1 2.2 2 0 0 2 2 2 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial FapA PF03961.13 CDW58589.1 - 0.36 9.4 4.6 0.52 8.8 4.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 CDW58589.1 - 1.3 8.2 3.9 2 7.6 3.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein Spatacsin_C PF14649.6 CDW58590.1 - 0.041 13.0 0.4 0.052 12.7 0.4 1.1 1 0 0 1 1 1 0 Spatacsin C-terminus PEHE PF15275.6 CDW58591.1 - 1.4e-06 29.0 1.5 1.4e-06 29.0 1.5 2.9 2 1 0 2 2 2 1 PEHE domain Patatin PF01734.22 CDW58591.1 - 0.035 14.3 0.2 0.048 13.8 0.2 1.3 1 0 0 1 1 1 0 Patatin-like phospholipase UMPH-1 PF05822.12 CDW58591.1 - 0.042 13.4 0.5 0.41 10.1 0.1 2.0 2 0 0 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) Q_salvage PF10343.9 CDW58593.1 - 2.2e-39 135.7 0.1 3.3e-39 135.2 0.1 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family adh_short_C2 PF13561.6 CDW58594.1 - 3.3e-56 190.5 0.1 1.6e-42 145.7 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDW58594.1 - 2.3e-49 167.5 0.1 3.1e-49 167.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CDW58594.1 - 6e-12 45.8 0.0 8.5e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CDW58594.1 - 0.0047 16.4 0.1 0.01 15.3 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family SAM_Ste50p PF09235.10 CDW58594.1 - 0.033 14.4 0.9 1.2 9.5 0.1 2.3 1 1 1 2 2 2 0 Ste50p, sterile alpha motif tRNA-synt_1d PF00750.19 CDW58595.1 - 7.3e-139 462.5 0.0 1.3e-138 461.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CDW58595.1 - 5.3e-31 107.3 1.0 1.2e-30 106.1 0.2 2.2 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 CDW58595.1 - 7.2e-19 68.2 0.2 5.6e-18 65.3 0.2 2.4 1 1 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 CDW58595.1 - 0.00027 20.4 0.0 0.00051 19.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CDW58595.1 - 0.024 13.4 0.0 0.044 12.5 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CDW58595.1 - 0.046 12.0 0.0 0.14 10.3 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (I, L, M and V) Cyt-b5 PF00173.28 CDW58596.1 - 1.7e-11 44.1 0.2 3.1e-11 43.2 0.2 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Fructosamin_kin PF03881.14 CDW58597.1 - 2.2e-67 227.3 0.0 4.1e-67 226.4 0.0 1.5 1 1 0 1 1 1 1 Fructosamine kinase PXA PF02194.15 CDW58597.1 - 1.7e-38 132.4 0.2 4e-38 131.2 0.2 1.7 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 CDW58597.1 - 1.2e-26 93.4 0.1 9.4e-26 90.6 0.0 2.4 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 CDW58597.1 - 4.3e-15 55.7 0.1 1.1e-14 54.3 0.1 1.7 1 0 0 1 1 1 1 PX domain RGS PF00615.19 CDW58597.1 - 6.3e-11 42.6 0.5 1.6e-10 41.3 0.5 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain APH PF01636.23 CDW58597.1 - 6.9e-10 39.3 0.0 1.6e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family MOR2-PAG1_N PF14222.6 CDW58598.1 - 7.2e-157 523.7 0.3 9.7e-157 523.2 0.3 1.2 1 0 0 1 1 1 1 Cell morphogenesis N-terminal Arm PF00514.23 CDW58598.1 - 2.1 8.5 5.1 0.78 9.9 0.3 2.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Tetraspanin PF00335.20 CDW58599.1 - 3.6e-13 49.8 4.4 4.9e-13 49.3 4.4 1.1 1 0 0 1 1 1 1 Tetraspanin family COX6C PF02937.15 CDW58599.1 - 1.2 9.3 7.3 0.16 12.1 1.4 2.5 2 1 0 2 2 2 0 Cytochrome c oxidase subunit VIc DUF1754 PF08555.10 CDW58600.1 - 1.6 9.6 17.5 12 6.7 17.5 2.6 1 1 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Cyclin_N PF00134.23 CDW58601.1 - 5.5e-08 32.6 0.3 1.8e-07 31.0 0.1 2.0 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CDW58601.1 - 0.0031 17.6 2.2 0.0089 16.1 0.9 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain Pkinase PF00069.25 CDW58602.1 - 1.5e-22 80.2 0.0 1.7e-22 80.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58602.1 - 5.1e-12 45.6 0.0 6.1e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW58602.1 - 7.6e-05 21.7 0.0 8.9e-05 21.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDW58602.1 - 0.0046 16.3 0.0 0.0068 15.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDW58602.1 - 0.2 11.0 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like PQQ PF01011.21 CDW58603.1 - 2.6e-08 33.4 0.0 0.00068 19.5 0.0 3.1 3 0 0 3 3 3 2 PQQ enzyme repeat PQQ_2 PF13360.6 CDW58603.1 - 6.3e-05 22.7 0.1 0.0012 18.5 0.0 2.8 1 1 1 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 CDW58603.1 - 0.011 16.2 1.2 2.2 8.9 0.0 4.4 5 1 0 5 5 5 0 PQQ-like domain SpoIIE PF07228.12 CDW58604.1 - 5.3e-15 55.8 0.0 7.6e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CDW58604.1 - 2.3e-10 40.5 0.0 3.2e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 CDW58604.1 - 2.6e-08 33.8 0.0 4.2e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C DUF4500 PF14937.6 CDW58605.1 - 0.0017 18.4 1.5 0.0047 16.9 0.2 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF4500) TetR_C_12 PF16914.5 CDW58605.1 - 0.061 13.5 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Bacterial transcriptional repressor C-terminal Viral_Beta_CD PF04530.12 CDW58605.1 - 0.17 12.2 1.3 3.3 8.0 0.1 2.7 3 0 0 3 3 3 0 Viral Beta C/D like family Ndc1_Nup PF09531.10 CDW58605.1 - 0.42 9.2 5.4 0.57 8.8 5.4 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2304 PF10066.9 CDW58605.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2304) Kunitz_BPTI PF00014.23 CDW58606.1 - 3.8e-57 190.4 49.9 1.5e-19 70.0 10.9 3.1 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain zf-C2H2 PF00096.26 CDW58607.1 - 3.1e-12 46.2 30.6 3.9e-06 27.0 1.0 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW58607.1 - 6.2e-12 45.4 5.8 6.9e-07 29.4 0.4 4.9 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW58607.1 - 1.6e-06 28.5 29.8 0.0015 19.2 0.9 4.3 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW58607.1 - 0.056 13.5 12.6 0.38 10.8 0.5 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CDW58607.1 - 0.062 13.6 9.1 0.036 14.3 5.0 2.2 1 1 1 2 2 2 0 C2H2-type zinc ribbon PLA2_B PF01735.18 CDW58607.1 - 0.065 11.6 0.3 0.087 11.2 0.3 1.1 1 0 0 1 1 1 0 Lysophospholipase catalytic domain zf-H2C2_5 PF13909.6 CDW58607.1 - 0.17 11.7 0.3 0.17 11.7 0.3 3.4 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-BED PF02892.15 CDW58607.1 - 0.2 11.7 13.0 8.5 6.5 0.9 3.5 1 1 2 3 3 3 0 BED zinc finger zf-C2H2_aberr PF17017.5 CDW58607.1 - 0.29 11.3 1.3 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 Aberrant zinc-finger zf_C2H2_ZHX PF18387.1 CDW58607.1 - 1.4 8.6 8.1 0.72 9.5 0.2 2.9 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-LYAR PF08790.11 CDW58607.1 - 1.6 8.7 6.3 3 7.8 0.1 2.9 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-RING_2 PF13639.6 CDW58608.1 - 3.1e-09 37.0 4.6 3.1e-09 37.0 4.6 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CDW58608.1 - 3e-06 26.9 3.8 3e-06 26.9 3.8 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CDW58608.1 - 7.6e-05 22.5 4.9 7.6e-05 22.5 4.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDW58608.1 - 0.0014 18.9 4.6 0.0014 18.9 4.6 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CDW58608.1 - 0.002 18.1 4.7 0.002 18.1 4.7 2.3 2 0 0 2 2 2 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CDW58608.1 - 0.0052 16.4 2.6 0.0052 16.4 2.6 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 CDW58608.1 - 0.028 14.3 5.0 0.028 14.3 5.0 2.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PRP21_like_P PF12230.8 CDW58608.1 - 0.036 13.9 0.0 0.042 13.7 0.0 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein zf_UBZ PF18439.1 CDW58608.1 - 0.063 12.9 1.1 0.12 12.0 1.1 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger zf-WRNIP1_ubi PF18279.1 CDW58608.1 - 0.19 12.5 0.2 0.19 12.5 0.2 1.9 2 0 0 2 2 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain RNF220 PF15926.5 CDW58608.1 - 0.24 11.0 1.9 0.36 10.4 1.9 1.3 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_3 PF13920.6 CDW58608.1 - 0.61 10.0 15.3 0.051 13.4 3.3 2.7 2 1 1 3 3 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW58608.1 - 1.4 9.0 11.2 2.2 8.3 3.4 2.3 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING-like PF08746.11 CDW58608.1 - 1.9 8.9 11.3 0.21 11.9 3.4 2.3 2 0 0 2 2 2 0 RING-like domain Prok-RING_1 PF14446.6 CDW58608.1 - 5.2 7.1 13.6 3.4 7.7 4.5 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 FANCL_C PF11793.8 CDW58608.1 - 6.7 7.0 10.7 0.93 9.7 3.9 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 CDW58608.1 - 8.5 6.6 12.0 0.15 12.2 4.5 2.0 2 0 0 2 2 2 0 RING-variant domain TB2_DP1_HVA22 PF03134.19 CDW58609.1 - 1.6e-28 98.5 7.3 1.6e-28 98.5 7.3 1.5 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Ras PF00071.22 CDW58610.1 - 3.6e-62 208.7 0.1 4.5e-62 208.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW58610.1 - 6e-35 120.1 0.1 8.4e-35 119.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW58610.1 - 3.4e-12 46.2 0.0 4.2e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW58610.1 - 1.8e-07 31.2 0.1 2.5e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW58610.1 - 5.9e-05 23.0 0.1 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CDW58610.1 - 0.00013 22.3 0.0 0.005 17.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 CDW58610.1 - 0.00056 19.5 0.1 0.0025 17.4 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CDW58610.1 - 0.0036 16.7 0.0 0.0051 16.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 CDW58610.1 - 0.0064 16.9 0.0 0.0089 16.4 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 CDW58610.1 - 0.017 14.6 0.0 0.031 13.7 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 CDW58610.1 - 0.02 14.9 0.0 0.043 13.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain FAD-SLDH PF12318.8 CDW58610.1 - 0.03 14.4 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase PduV-EutP PF10662.9 CDW58610.1 - 0.03 14.1 0.0 0.11 12.3 0.0 1.8 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 CDW58610.1 - 0.032 14.7 0.1 0.057 13.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 CDW58610.1 - 0.049 13.0 0.0 0.14 11.5 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 CDW58610.1 - 0.085 12.6 0.1 0.16 11.6 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 CDW58610.1 - 0.087 12.6 0.1 0.2 11.4 0.1 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MCM PF00493.23 CDW58610.1 - 0.087 11.9 0.0 0.16 11.1 0.0 1.5 1 1 0 1 1 1 0 MCM P-loop domain FeoB_N PF02421.18 CDW58610.1 - 0.1 12.1 0.1 0.19 11.2 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_5 PF07728.14 CDW58610.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CDW58610.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Glyco_hydro_15 PF00723.21 CDW58611.1 - 1.1e-105 354.1 0.0 1.4e-105 353.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 NEMP PF10225.9 CDW58612.1 - 3.4e-48 164.5 9.5 4.8e-48 164.0 9.5 1.1 1 0 0 1 1 1 1 NEMP family BIV_Env PF05858.12 CDW58612.1 - 1.6 6.9 5.4 0.96 7.5 2.2 2.0 1 1 1 2 2 2 0 Bovine immunodeficiency virus surface protein (SU) Kelch_5 PF13854.6 CDW58613.1 - 1.6e-08 34.3 0.0 0.0017 18.3 0.0 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 CDW58613.1 - 3.8e-07 29.8 0.4 8.9e-05 22.3 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 CDW58613.1 - 5.5e-06 25.9 0.8 0.00059 19.4 0.2 2.4 2 1 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 CDW58613.1 - 9.8e-05 22.5 0.8 0.012 15.9 0.1 2.4 2 1 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 CDW58613.1 - 0.0095 15.9 0.1 4 7.5 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Cupin_7 PF12973.7 CDW58613.1 - 0.07 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 ChrR Cupin-like domain Kelch_3 PF13415.6 CDW58613.1 - 0.088 13.1 1.4 13 6.2 0.1 3.1 3 1 0 3 3 3 0 Galactose oxidase, central domain Dimer_Tnp_hAT PF05699.14 CDW58614.1 - 3.1e-05 23.7 0.1 4.4e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region DUF4286 PF14114.6 CDW58615.1 - 0.12 12.9 0.1 5.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4286) SAM_2 PF07647.17 CDW58616.1 - 1.9e-22 79.1 0.0 1.9e-12 47.1 0.0 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CDW58616.1 - 1.3e-18 67.2 0.3 1.7e-12 47.6 0.1 3.0 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) TIR_2 PF13676.6 CDW58616.1 - 6.7e-11 42.8 0.0 1.9e-10 41.4 0.0 1.8 1 0 0 1 1 1 1 TIR domain UNC45-central PF11701.8 CDW58616.1 - 4.6e-05 23.4 3.5 4.6e-05 23.4 3.5 2.1 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central RIX1 PF08167.12 CDW58616.1 - 0.094 12.4 0.4 1.9 8.2 0.1 3.0 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis EF-hand_7 PF13499.6 CDW58617.1 - 8e-10 39.0 0.6 1.6e-09 38.1 0.3 1.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CDW58617.1 - 7.2e-09 34.6 0.2 0.00042 19.7 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 CDW58617.1 - 5e-08 32.3 0.5 0.0081 16.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 CDW58617.1 - 2.1e-05 23.8 0.4 0.0084 15.6 0.1 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 CDW58617.1 - 0.0046 17.3 0.2 0.99 9.8 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 CDW58617.1 - 0.0083 15.9 0.5 0.083 12.8 0.4 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.7 CDW58617.1 - 0.017 15.1 0.3 0.085 12.8 0.1 1.9 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 CDW58617.1 - 0.053 13.7 3.3 3.5 7.9 0.1 2.3 1 1 1 2 2 2 0 Dockerin type I domain CENP-P PF13096.6 CDW58617.1 - 0.17 11.6 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P PNK3P PF08645.11 CDW58618.1 - 6.2e-52 175.6 0.0 9.5e-52 175.0 0.0 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 CDW58618.1 - 3.3e-17 63.0 0.7 2.4e-08 34.3 0.2 2.4 1 1 1 2 2 2 2 AAA domain FHA_2 PF17913.1 CDW58618.1 - 2.8e-15 56.3 0.0 1e-14 54.5 0.0 1.9 2 0 0 2 2 2 1 FHA domain FHA PF00498.26 CDW58618.1 - 3.1e-05 24.2 0.1 8.9e-05 22.8 0.1 1.9 2 0 0 2 2 2 1 FHA domain 6PF2K PF01591.18 CDW58618.1 - 0.048 13.0 2.2 0.79 9.0 0.0 2.7 2 1 0 3 3 3 0 6-phosphofructo-2-kinase AAA_17 PF13207.6 CDW58618.1 - 0.055 13.9 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Hydrolase_6 PF13344.6 CDW58618.1 - 0.073 13.2 0.1 0.51 10.5 0.0 2.3 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase AAA_18 PF13238.6 CDW58618.1 - 0.084 13.4 0.0 0.16 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDW58618.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 CDW58618.1 - 0.15 11.5 3.4 0.67 9.3 0.4 2.1 1 1 1 2 2 2 0 Chromatin associated protein KTI12 AAA_22 PF13401.6 CDW58618.1 - 0.16 12.2 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Lustrin_cystein PF14625.6 CDW58619.1 - 8.4e-66 218.1 262.4 7.8e-09 35.8 11.4 18.2 16 2 0 16 16 16 13 Lustrin, cysteine-rich repeated domain Kunitz_BPTI PF00014.23 CDW58619.1 - 5.8e-43 144.9 53.3 1e-16 60.9 6.0 5.9 5 0 0 5 5 5 3 Kunitz/Bovine pancreatic trypsin inhibitor domain EB PF01683.18 CDW58619.1 - 5.5e-08 33.0 8.0 5.5e-08 33.0 8.0 13.9 10 6 1 11 11 11 3 EB module Jagunal PF07086.12 CDW58620.1 - 0.0025 17.9 0.1 0.0043 17.2 0.1 1.3 1 1 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis AWS PF17907.1 CDW58620.1 - 0.005 16.9 1.2 3.2 7.9 0.1 2.8 2 0 0 2 2 2 2 AWS domain RICTOR_M PF14666.6 CDW58620.1 - 0.11 12.2 1.0 0.99 9.2 0.1 2.6 2 1 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain UPF0203 PF05254.12 CDW58620.1 - 0.47 10.7 9.8 0.33 11.2 2.2 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0203) NPL4 PF05021.15 CDW58621.1 - 1.5e-71 241.3 0.0 2.2e-71 240.8 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 CDW58621.1 - 1.5e-48 164.6 0.4 2.6e-48 163.9 0.4 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region zf-RanBP PF00641.18 CDW58621.1 - 0.00057 19.2 3.7 0.00057 19.2 3.7 3.1 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others Fez1 PF06818.15 CDW58623.1 - 0.00058 20.4 18.4 0.0014 19.1 18.4 1.6 1 1 0 1 1 1 1 Fez1 Bacillus_HBL PF05791.11 CDW58623.1 - 0.00071 19.4 1.0 0.00098 19.0 1.0 1.2 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) ADIP PF11559.8 CDW58623.1 - 0.0015 18.7 20.1 0.0016 18.5 18.9 1.8 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 CDW58623.1 - 0.0053 15.7 19.1 0.025 13.5 18.1 1.9 1 1 0 1 1 1 1 Spc7 kinetochore protein Cep57_CLD_2 PF14197.6 CDW58623.1 - 0.008 16.2 7.4 0.008 16.2 7.4 2.5 1 1 1 2 2 2 1 Centrosome localisation domain of PPC89 Lectin_N PF03954.14 CDW58623.1 - 0.0098 15.6 4.4 0.023 14.4 4.3 1.7 1 1 0 1 1 1 1 Hepatic lectin, N-terminal domain DUF4407 PF14362.6 CDW58623.1 - 0.029 13.7 9.6 0.033 13.5 9.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Gal-3-0_sulfotr PF06990.11 CDW58623.1 - 0.076 11.9 3.7 0.03 13.2 0.9 1.6 1 1 1 2 2 2 0 Galactose-3-O-sulfotransferase TPR_MLP1_2 PF07926.12 CDW58623.1 - 0.091 12.8 18.7 0.93 9.6 12.5 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spore_GerAC PF05504.11 CDW58623.1 - 0.17 12.1 6.7 0.11 12.7 3.2 2.0 1 1 1 2 2 2 0 Spore germination B3/ GerAC like, C-terminal Atg14 PF10186.9 CDW58623.1 - 0.2 10.7 14.8 0.25 10.4 14.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 CDW58623.1 - 0.27 11.3 8.6 0.36 10.9 1.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-H PF05837.12 CDW58623.1 - 0.38 11.2 16.9 1.6 9.2 1.6 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF4200 PF13863.6 CDW58623.1 - 0.56 10.6 18.1 0.98 9.8 15.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF5082 PF16888.5 CDW58623.1 - 0.6 10.4 10.9 2.8 8.2 1.5 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) Hemagglutinin PF00509.18 CDW58623.1 - 0.87 7.9 6.0 4.3 5.6 0.3 2.0 1 1 1 2 2 2 0 Haemagglutinin LMBR1 PF04791.16 CDW58623.1 - 0.88 8.4 10.8 0.9 8.4 10.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM76 PF16046.5 CDW58623.1 - 1.1 8.6 13.6 0.077 12.3 5.7 2.0 1 1 1 2 2 2 0 FAM76 protein Jnk-SapK_ap_N PF09744.9 CDW58623.1 - 1.5 9.0 21.9 2.3 8.4 14.6 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 CDW58623.1 - 1.6 9.0 24.8 1 9.5 3.7 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Goodbye PF17109.5 CDW58623.1 - 1.6 9.2 5.8 1.4 9.4 0.3 2.1 1 1 2 3 3 3 0 fungal STAND N-terminal Goodbye domain Exonuc_VII_L PF02601.15 CDW58623.1 - 1.7 8.1 13.0 2.2 7.8 13.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc24 PF08286.11 CDW58623.1 - 2.1 8.7 14.7 1.6 9.0 1.1 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 HAUS-augmin3 PF14932.6 CDW58623.1 - 2.7 7.5 18.4 3.8 7.0 0.3 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 FUSC PF04632.12 CDW58623.1 - 3.2 6.2 9.8 5.4 5.4 9.8 1.3 1 1 0 1 1 1 0 Fusaric acid resistance protein family TRAF_BIRC3_bd PF16673.5 CDW58623.1 - 4.4 7.2 15.4 0.41 10.5 2.4 3.5 1 1 2 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain APG6_N PF17675.1 CDW58623.1 - 4.4 7.8 22.7 2.1 8.9 4.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region AAA_13 PF13166.6 CDW58623.1 - 4.4 5.8 14.2 28 3.2 14.6 1.7 1 1 0 1 1 1 0 AAA domain DUF5401 PF17380.2 CDW58623.1 - 5.3 5.0 20.4 6.2 4.8 20.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) TMF_DNA_bd PF12329.8 CDW58623.1 - 7.6 6.6 18.2 5.8 7.0 4.5 2.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF2203 PF09969.9 CDW58623.1 - 8.9 7.1 10.5 14 6.4 6.6 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) HTH_41 PF14502.6 CDW58624.1 - 0.019 14.7 0.1 0.053 13.2 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain MCM PF00493.23 CDW58625.1 - 1.4e-94 315.4 0.1 1.9e-94 314.9 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDW58625.1 - 1.8e-32 111.9 0.0 3.3e-32 111.0 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDW58625.1 - 5.6e-23 81.2 1.9 1.2e-22 80.1 1.9 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDW58625.1 - 1.2e-09 38.7 0.3 9.1e-09 35.9 0.0 2.6 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 CDW58625.1 - 9.6e-07 28.4 0.1 2.3e-05 23.9 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDW58625.1 - 0.014 15.4 0.0 0.037 14.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDW58625.1 - 0.017 15.0 0.0 0.045 13.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HMG-CoA_red PF00368.18 CDW58626.1 - 3.7e-127 424.3 0.0 4.3e-127 424.1 0.0 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase EB PF01683.18 CDW58627.1 - 1.8e-18 66.6 43.1 2.2e-09 37.5 12.8 7.4 5 3 2 7 7 7 3 EB module Lustrin_cystein PF14625.6 CDW58627.1 - 3.6e-08 33.6 16.7 2.4e-07 31.0 6.0 9.0 7 3 2 9 9 9 3 Lustrin, cysteine-rich repeated domain PP1_inhibitor PF05361.12 CDW58630.1 - 0.019 15.0 0.6 0.021 14.8 0.6 1.1 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor DUF89 PF01937.19 CDW58631.1 - 1.4e-95 320.3 0.2 1.9e-95 319.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF89 GST_C_4 PF14834.6 CDW58631.1 - 0.1 13.0 0.0 0.21 12.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Striatin PF08232.12 CDW58632.1 - 1e-43 149.6 3.6 5.6e-43 147.2 3.6 2.1 1 1 0 1 1 1 1 Striatin family DUF4482 PF14818.6 CDW58632.1 - 0.077 13.9 2.1 0.18 12.7 2.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) CENP-H PF05837.12 CDW58632.1 - 0.08 13.4 0.6 0.19 12.1 0.6 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Trypsin PF00089.26 CDW58633.1 - 3.9e-23 82.4 0.0 7e-12 45.6 0.0 2.7 2 2 0 2 2 2 2 Trypsin DUF316 PF03761.15 CDW58633.1 - 0.14 11.7 0.0 0.92 9.0 0.0 2.0 2 0 0 2 2 2 0 Chymotrypsin family Peptidase-S1 Motile_Sperm PF00635.26 CDW58634.1 - 3.3e-11 43.0 0.1 4.6e-11 42.5 0.1 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DEC-1_N PF04625.13 CDW58634.1 - 0.14 11.1 1.2 0.18 10.8 1.2 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Ribosomal_60s PF00428.19 CDW58634.1 - 0.25 12.0 8.5 0.37 11.4 8.5 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein CLP1_P PF16575.5 CDW58635.1 - 5.6e-67 225.2 0.0 7.9e-67 224.7 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 CDW58635.1 - 1.9e-31 108.9 0.0 3.2e-31 108.2 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 CDW58635.1 - 1.3e-27 95.8 0.0 2.2e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor MMR_HSR1 PF01926.23 CDW58635.1 - 0.0061 16.6 0.0 0.015 15.3 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase ZF-HD_dimer PF04770.12 CDW58635.1 - 0.24 11.8 0.7 0.62 10.4 0.2 1.9 2 0 0 2 2 2 0 ZF-HD protein dimerisation region CAP PF00188.26 CDW58636.1 - 1.6e-12 48.3 0.1 2e-12 48.1 0.1 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF2888 PF11135.8 CDW58636.1 - 0.0066 16.4 0.0 0.0091 16.0 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2888) Asparaginase_2 PF01112.18 CDW58637.1 - 8.1e-50 169.6 0.4 1e-49 169.2 0.4 1.1 1 0 0 1 1 1 1 Asparaginase Glyco_transf_10 PF00852.19 CDW58638.1 - 1.2e-63 214.0 5.9 1.7e-63 213.5 5.9 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW58638.1 - 7.5e-16 58.6 0.3 6e-15 55.7 0.0 2.3 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal CH PF00307.31 CDW58639.1 - 4.3e-14 52.6 0.7 6.7e-14 52.0 0.7 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain EB1 PF03271.17 CDW58639.1 - 5.5e-14 52.1 3.2 6.3e-14 51.9 2.1 1.7 2 0 0 2 2 2 1 EB1-like C-terminal motif CAMSAP_CH PF11971.8 CDW58639.1 - 0.0066 16.2 0.1 0.012 15.4 0.1 1.4 1 0 0 1 1 1 1 CAMSAP CH domain CH_2 PF06294.11 CDW58639.1 - 0.065 13.4 0.4 0.12 12.5 0.4 1.6 1 0 0 1 1 1 0 CH-like domain in sperm protein AA_permease_2 PF13520.6 CDW58641.1 - 3.7e-49 167.7 46.3 5.8e-48 163.8 46.3 2.0 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CDW58641.1 - 5.6e-23 81.3 33.9 1.1e-22 80.3 33.9 1.5 1 1 0 1 1 1 1 Amino acid permease EMP24_GP25L PF01105.24 CDW58642.1 - 3.5e-49 167.2 0.3 4e-49 167.0 0.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF5070 PF16802.5 CDW58642.1 - 0.015 15.2 0.9 0.074 13.0 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5070) JIP_LZII PF16471.5 CDW58642.1 - 0.051 13.7 0.7 0.094 12.9 0.7 1.4 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II TSC22 PF01166.18 CDW58642.1 - 0.14 12.5 3.0 0.25 11.7 3.0 1.3 1 0 0 1 1 1 0 TSC-22/dip/bun family DUF2721 PF11026.8 CDW58642.1 - 4.7 7.1 7.5 1.4 8.8 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) MBOAT PF03062.19 CDW58643.1 - 3.2e-11 43.2 0.1 4.6e-11 42.7 0.1 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DNApol_Exo PF18136.1 CDW58644.1 - 1e-82 277.5 0.5 1.2e-80 270.6 0.5 2.3 1 1 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 CDW58644.1 - 2.1e-39 135.7 0.0 3.4e-39 135.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 CDW58644.1 - 0.0092 15.7 0.0 0.38 10.4 0.0 2.3 2 0 0 2 2 2 1 3'-5' exonuclease DUF3653 PF12375.8 CDW58644.1 - 0.17 12.0 0.0 12 6.1 0.0 2.7 2 0 0 2 2 2 0 Phage protein Fer2_3 PF13085.6 CDW58645.1 - 5.5e-34 116.5 0.3 9.1e-34 115.7 0.3 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 CDW58645.1 - 2.3e-08 34.4 3.5 2.3e-08 34.4 3.5 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDW58645.1 - 2.2e-07 30.9 2.7 2.2e-07 30.9 2.7 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDW58645.1 - 9.9e-06 25.9 6.0 9.9e-06 25.9 6.0 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer2 PF00111.27 CDW58645.1 - 0.0057 16.6 2.4 0.0057 16.6 2.4 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 CDW58645.1 - 0.021 15.4 4.9 0.021 15.4 4.9 2.5 2 2 0 2 2 2 0 4Fe-4S dicluster domain CTV_P23 PF04808.12 CDW58645.1 - 0.11 12.0 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 Citrus tristeza virus (CTV) P23 protein Fer4_9 PF13187.6 CDW58645.1 - 2.8 8.2 15.5 0.18 12.0 7.3 2.7 2 1 0 2 2 2 0 4Fe-4S dicluster domain Hexapep PF00132.24 CDW58646.1 - 1.6e-09 37.1 8.4 0.00016 21.3 2.0 4.3 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 CDW58646.1 - 0.00019 20.5 0.3 0.00019 20.5 0.3 1.2 1 0 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 CDW58646.1 - 0.0088 15.8 7.4 0.012 15.4 1.5 3.2 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Exostosin PF03016.15 CDW58647.1 - 1.3e-17 64.0 0.0 1.8e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Exostosin family fn3 PF00041.21 CDW58649.1 - 1.9e-52 175.5 0.0 1.7e-14 53.9 0.0 4.3 4 0 0 4 4 4 4 Fibronectin type III domain Arm PF00514.23 CDW58649.1 - 4.3e-37 125.0 4.5 2.6e-08 33.6 0.1 6.6 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat Pur_ac_phosph_N PF16656.5 CDW58649.1 - 3.5e-10 40.3 0.3 0.35 11.5 0.0 5.7 4 2 0 4 4 4 3 Purple acid Phosphatase, N-terminal domain HEAT_EZ PF13513.6 CDW58649.1 - 6.5e-08 32.9 1.5 0.0064 17.0 0.1 5.3 4 1 2 6 6 6 1 HEAT-like repeat HEAT PF02985.22 CDW58649.1 - 3.4e-07 30.0 4.3 1.2 9.5 0.1 5.6 3 1 2 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 CDW58649.1 - 1.1e-06 29.0 0.4 0.033 14.6 0.2 3.5 2 1 1 3 3 3 2 HEAT repeats Atx10homo_assoc PF09759.9 CDW58649.1 - 1.1e-06 28.6 0.7 0.00024 21.1 0.1 2.7 2 1 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain SusE PF14292.6 CDW58649.1 - 0.00043 20.5 0.0 0.29 11.4 0.0 3.8 4 0 0 4 4 4 1 SusE outer membrane protein fn3_4 PF16794.5 CDW58649.1 - 0.0015 18.4 0.0 0.056 13.4 0.0 3.5 5 1 0 5 5 5 1 Fibronectin-III type domain Tissue_fac PF01108.17 CDW58649.1 - 0.0093 15.8 0.1 0.59 10.0 0.3 3.6 3 1 0 3 3 3 1 Tissue factor Adaptin_N PF01602.20 CDW58649.1 - 0.014 14.0 0.0 2.8 6.4 0.0 2.3 2 0 0 2 2 2 0 Adaptin N terminal region He_PIG PF05345.12 CDW58649.1 - 0.02 15.1 0.1 84 3.5 0.0 4.2 4 0 0 4 4 4 0 Putative Ig domain Pkinase PF00069.25 CDW58652.1 - 2.8e-49 167.9 0.0 3.6e-49 167.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58652.1 - 9.8e-32 110.2 0.0 1.4e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW58652.1 - 6.4e-09 35.5 0.0 8.4e-08 31.9 0.0 2.3 1 1 0 1 1 1 1 Kinase-like Nucleopor_Nup85 PF07575.13 CDW58652.1 - 0.076 11.6 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 Nup85 Nucleoporin Kdo PF06293.14 CDW58652.1 - 0.076 12.4 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW58652.1 - 0.08 11.7 0.1 0.14 10.9 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase IPK PF03770.16 CDW58653.1 - 1.9e-48 165.0 0.0 2.5e-48 164.6 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase TM2 PF05154.16 CDW58654.1 - 3.7e-11 43.2 8.0 5.7e-11 42.6 8.0 1.3 1 0 0 1 1 1 1 TM2 domain adh_short PF00106.25 CDW58656.1 - 8.8e-28 97.1 0.0 1e-20 74.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CDW58656.1 - 1e-18 67.7 0.0 4.3e-15 55.9 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CDW58656.1 - 7.9e-05 22.2 0.0 0.00014 21.4 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CDW58656.1 - 9.2e-05 22.4 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CDW58656.1 - 0.002 17.6 0.0 0.0088 15.5 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Paf1 PF03985.13 CDW58657.1 - 1.6e-47 162.5 14.5 3e-24 85.8 4.2 3.0 2 1 1 3 3 3 3 Paf1 PSI_integrin PF17205.3 CDW58657.1 - 0.052 13.3 0.6 0.052 13.3 0.6 2.1 2 0 0 2 2 2 0 Integrin plexin domain HAD_2 PF13419.6 CDW58658.1 - 7.1e-22 78.3 0.0 8.3e-22 78.1 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW58658.1 - 2.7e-13 50.7 0.0 4.8e-11 43.4 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW58658.1 - 5.8e-06 26.3 0.0 1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 CDW58658.1 - 4.8e-05 23.8 0.0 6.1e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW58658.1 - 0.019 15.0 0.0 0.33 11.1 0.0 2.4 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase tRNA_m1G_MT PF01746.21 CDW58659.1 - 3.8e-23 82.2 0.0 6.8e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase SPA PF08616.10 CDW58659.1 - 5.7e-11 42.4 0.0 1.3e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 CDW58659.1 - 0.0028 16.4 0.0 0.0051 15.6 0.0 1.4 1 0 0 1 1 1 1 Transport protein Avl9 DENN PF02141.21 CDW58659.1 - 0.011 15.7 1.2 0.34 10.9 1.2 2.5 1 1 0 1 1 1 0 DENN (AEX-3) domain tRNA_m1G_MT PF01746.21 CDW58660.1 - 3e-26 92.3 0.0 5.2e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Lactamase_B_2 PF12706.7 CDW58660.1 - 3.6e-17 62.6 0.2 2.8e-16 59.6 0.0 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 CDW58660.1 - 3e-14 52.4 0.1 1.8e-13 49.9 0.0 2.3 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B PF00753.27 CDW58660.1 - 1.9e-06 28.0 0.0 0.00062 19.8 0.0 2.5 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Cytochrom_B_N_2 PF13631.6 CDW58660.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB Bromodomain PF00439.25 CDW58661.1 - 2.4e-19 69.2 0.6 5.1e-19 68.1 0.6 1.5 1 0 0 1 1 1 1 Bromodomain WSD PF15613.6 CDW58661.1 - 0.0092 16.4 0.0 0.0092 16.4 0.0 3.0 3 1 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif GTP_EFTU PF00009.27 CDW58662.1 - 5.2e-16 58.8 0.0 9.5e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CDW58662.1 - 2.8e-05 24.4 0.2 9.6e-05 22.7 0.2 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CDW58662.1 - 0.012 15.5 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase FtsJ PF01728.19 CDW58663.1 - 2.3e-65 220.0 0.0 3e-65 219.7 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase NAD_binding_1 PF00175.21 CDW58665.1 - 3.8e-18 66.1 0.0 7.8e-18 65.1 0.0 1.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain bacHORMA_1 PF18138.1 CDW58665.1 - 0.044 13.7 1.2 2.1 8.2 0.1 2.1 2 0 0 2 2 2 0 Bacterial HORMA domain family 1 Kunitz_BPTI PF00014.23 CDW58666.1 - 3e-26 91.4 23.5 4e-14 52.6 3.0 2.7 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 CDW58666.1 - 1.3e-20 73.5 45.8 2.7e-08 34.1 5.2 5.6 5 0 0 5 5 5 4 Lustrin, cysteine-rich repeated domain Lustrin_cystein PF14625.6 CDW58667.1 - 1.8e-17 63.4 34.9 1.8e-06 28.2 6.8 3.1 3 0 0 3 3 3 3 Lustrin, cysteine-rich repeated domain HEV_ORF1 PF02444.16 CDW58667.1 - 0.069 13.7 0.6 0.069 13.7 0.6 3.0 3 0 0 3 3 3 0 Hepatitis E virus ORF-2 (Putative capsid protein) CBM_19 PF03427.13 CDW58667.1 - 0.52 10.3 11.0 0.55 10.3 0.1 4.0 3 1 0 3 3 3 0 Carbohydrate binding domain (family 19) Inhibitor_I36 PF03995.13 CDW58667.1 - 0.86 9.6 6.0 4.7 7.2 0.2 2.7 2 0 0 2 2 2 0 Peptidase inhibitor family I36 Lustrin_cystein PF14625.6 CDW58668.1 - 2.7e-20 72.4 53.5 1.4e-06 28.6 6.5 4.8 4 1 1 5 5 5 4 Lustrin, cysteine-rich repeated domain Dickkopf_N PF04706.12 CDW58668.1 - 0.0049 17.3 6.1 0.0049 17.3 6.1 4.3 4 0 0 4 4 4 1 Dickkopf N-terminal cysteine-rich region Integrase_H2C2 PF17921.1 CDW58669.1 - 4.4e-06 26.7 0.0 1.9e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CDW58669.1 - 0.0013 19.0 0.0 0.0026 18.0 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Flu_PB1 PF00602.17 CDW58669.1 - 0.27 9.3 0.4 0.37 8.9 0.4 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 UL45 PF05473.12 CDW58670.1 - 0.072 12.7 0.1 0.13 11.9 0.0 1.4 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like DUF846 PF05832.12 CDW58671.1 - 1.2e-41 142.0 15.8 1.4e-41 141.8 15.8 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Corona_NS3b PF03053.14 CDW58671.1 - 1.3 8.7 9.8 2.4 7.8 2.1 2.1 2 0 0 2 2 2 0 ORF3b coronavirus protein NRDE-2 PF08424.10 CDW58672.1 - 3.7e-50 170.9 8.7 3.7e-50 170.9 8.7 2.6 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference Atrophin-1 PF03154.15 CDW58672.1 - 0.79 7.9 7.6 1.1 7.4 7.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family VAD1-2 PF15310.6 CDW58672.1 - 0.93 9.3 5.5 1.7 8.5 5.5 1.4 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling NARP1 PF12569.8 CDW58672.1 - 1.8 7.4 11.3 17 4.2 0.0 2.3 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 SR-25 PF10500.9 CDW58672.1 - 8.9 5.8 18.4 0.44 10.1 12.8 1.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Med1 PF10744.9 CDW58673.1 - 4.8e-07 29.2 1.1 0.0043 16.2 0.1 2.4 2 0 0 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 CHGN PF05679.16 CDW58674.1 - 2e-90 304.1 0.1 2e-90 304.1 0.1 1.6 2 0 0 2 2 2 1 Chondroitin N-acetylgalactosaminyltransferase Peptidase_M16 PF00675.20 CDW58674.1 - 0.17 11.9 1.8 0.5 10.3 0.0 2.5 3 0 0 3 3 3 0 Insulinase (Peptidase family M16) Pepsin-I3 PF06394.13 CDW58674.1 - 1.2 9.4 6.1 9.6 6.5 0.6 2.9 3 0 0 3 3 3 0 Pepsin inhibitor-3-like repeated domain ACCA PF03255.14 CDW58675.1 - 0.0013 18.6 1.5 0.0017 18.2 1.5 1.1 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit APG6_N PF17675.1 CDW58675.1 - 0.0021 18.6 3.7 0.0025 18.3 3.7 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region ADIP PF11559.8 CDW58675.1 - 0.0051 16.9 3.5 0.0061 16.7 3.5 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF3847 PF12958.7 CDW58675.1 - 0.0072 16.4 7.1 0.0072 16.4 7.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3847) Fib_alpha PF08702.10 CDW58675.1 - 0.025 14.8 2.5 0.03 14.5 2.5 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 CDW58675.1 - 0.03 13.6 3.0 0.039 13.3 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PI3K_P85_iSH2 PF16454.5 CDW58675.1 - 0.036 13.7 5.0 0.049 13.2 5.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TMF_TATA_bd PF12325.8 CDW58675.1 - 0.049 13.9 2.1 0.049 13.9 2.1 1.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 CDW58675.1 - 0.068 12.9 8.3 0.18 11.6 8.3 1.7 1 1 0 1 1 1 0 Septum formation initiator DUF724 PF05266.14 CDW58675.1 - 0.11 12.3 7.0 0.061 13.1 5.1 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF724) GIT_CC PF16559.5 CDW58675.1 - 0.16 11.9 4.5 0.38 10.6 0.8 2.1 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1843 PF08898.10 CDW58675.1 - 0.18 12.4 7.2 6.8 7.3 2.8 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1843) DUF5595 PF18077.1 CDW58675.1 - 0.19 11.8 4.8 0.41 10.8 4.6 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5595) YabA PF06156.13 CDW58675.1 - 0.59 10.8 4.3 0.8 10.4 4.3 1.2 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 CDW58675.1 - 1.2 9.6 10.9 5.1 7.6 10.9 1.9 1 1 0 1 1 1 0 Cell division protein ZapB DUF1192 PF06698.11 CDW58675.1 - 2.6 8.2 8.8 10 6.3 1.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) Rab_bind PF16704.5 CDW58675.1 - 2.6 8.1 10.2 1.8 8.6 4.0 2.2 1 1 1 2 2 2 0 Rab binding domain WH2 PF02205.20 CDW58676.1 - 1.7e-05 24.5 0.7 4.2e-05 23.2 0.7 1.7 1 0 0 1 1 1 1 WH2 motif Zip PF02535.22 CDW58678.1 - 3.1 6.9 5.6 0.49 9.6 1.0 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Rho_GDI PF02115.17 CDW58680.1 - 4.1e-62 209.4 0.3 5e-62 209.1 0.3 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor SET PF00856.28 CDW58681.1 - 2e-09 38.0 0.0 4.5e-09 36.9 0.0 1.5 1 1 0 1 1 1 1 SET domain VHS PF00790.19 CDW58682.1 - 1.7e-35 121.9 0.0 4.6e-35 120.5 0.0 1.7 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 CDW58682.1 - 2.1e-18 66.4 5.8 2.4e-18 66.2 3.2 2.3 2 0 0 2 2 2 1 GAT domain Allexi_40kDa PF05549.11 CDW58682.1 - 0.0076 15.8 0.4 0.013 15.0 0.4 1.3 1 0 0 1 1 1 1 Allexivirus 40kDa protein ENTH PF01417.20 CDW58682.1 - 0.011 15.8 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 ENTH domain DUF4709 PF15821.5 CDW58682.1 - 0.055 13.7 0.5 0.19 12.0 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4709) Ldh_1_N PF00056.23 CDW58684.1 - 7.1e-45 152.6 0.0 1.4e-44 151.6 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDW58684.1 - 2e-24 86.4 0.0 3.4e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 CDW58684.1 - 0.0011 18.5 0.1 0.011 15.3 0.0 2.3 2 0 0 2 2 2 1 Family 4 glycosyl hydrolase UDPG_MGDP_dh_N PF03721.14 CDW58684.1 - 0.093 12.3 0.2 0.15 11.6 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain N6_N4_Mtase PF01555.18 CDW58684.1 - 0.17 11.6 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 DNA methylase RVT_1 PF00078.27 CDW58685.1 - 2e-15 57.0 0.0 5.8e-15 55.4 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 CDW58685.1 - 1.4e-08 35.1 0.0 3.5e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW58685.1 - 3e-07 31.0 0.0 8e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease FlgN PF05130.12 CDW58685.1 - 0.016 15.7 3.3 0.041 14.4 3.3 1.6 1 0 0 1 1 1 0 FlgN protein Sec34 PF04136.15 CDW58685.1 - 0.055 13.3 2.2 0.086 12.7 2.2 1.3 1 0 0 1 1 1 0 Sec34-like family RVP PF00077.20 CDW58685.1 - 0.073 13.4 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease SecY PF00344.20 CDW58686.1 - 1.2e-72 244.7 9.0 1.7e-72 244.3 9.0 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 CDW58686.1 - 4.3e-18 64.9 1.8 5.8e-18 64.4 0.1 2.2 2 0 0 2 2 2 1 Plug domain of Sec61p DUF2975 PF11188.8 CDW58686.1 - 0.0043 16.9 8.6 0.0059 16.5 4.1 3.5 2 1 1 3 3 3 1 Protein of unknown function (DUF2975) PL48 PF15903.5 CDW58687.1 - 2.8e-25 89.0 0.0 4.9e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Filopodia upregulated, FAM65 HEAT_2 PF13646.6 CDW58687.1 - 3.2e-06 27.4 0.6 1.4e-05 25.3 0.2 2.4 2 0 0 2 2 2 1 HEAT repeats XRN_N PF03159.18 CDW58688.1 - 4.8e-72 242.3 0.1 1.5e-40 139.2 0.0 2.2 2 0 0 2 2 2 2 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 CDW58688.1 - 2e-59 201.7 5.4 6.4e-41 140.7 1.3 2.3 2 0 0 2 2 2 2 Xrn1 helical domain DnaJ PF00226.31 CDW58690.1 - 1.8e-18 66.4 0.4 1.8e-18 66.4 0.4 1.9 2 0 0 2 2 2 1 DnaJ domain Thioredoxin PF00085.20 CDW58690.1 - 1.1e-07 31.8 0.0 2.3e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TPT PF03151.16 CDW58691.1 - 3.8e-73 246.4 23.7 4.3e-73 246.2 23.7 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CDW58691.1 - 6.4e-14 52.3 28.9 2.2e-08 34.4 10.2 2.0 2 0 0 2 2 2 2 EamA-like transporter family EMC3_TMCO1 PF01956.16 CDW58691.1 - 2.2 8.0 9.0 6.1 6.5 1.0 3.2 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like HEPN_SAV2148 PF18725.1 CDW58692.1 - 5.1e-05 22.8 5.7 6.5 6.1 0.1 4.2 4 0 0 4 4 4 4 SAV2148-like HEPN Stevor PF17410.2 CDW58692.1 - 0.009 15.6 0.0 83 2.6 0.0 4.5 5 0 0 5 5 5 0 Subtelomeric Variable Open Reading frame CAMSAP_CKK PF08683.11 CDW58692.1 - 0.28 11.3 5.6 14 5.8 0.0 4.2 5 0 0 5 5 5 0 Microtubule-binding calmodulin-regulated spectrin-associated FAD-oxidase_C PF02913.19 CDW58693.1 - 3.6e-48 164.4 0.0 5.9e-48 163.7 0.0 1.3 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CDW58693.1 - 4.4e-26 91.3 0.0 7.3e-26 90.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Calreticulin PF00262.18 CDW58694.1 - 7.6e-85 285.0 14.1 1.9e-60 204.7 3.6 2.3 1 1 1 2 2 2 2 Calreticulin family CDC45 PF02724.14 CDW58694.1 - 3.6 5.8 9.1 4.8 5.3 9.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RINGv PF12906.7 CDW58695.1 - 1.6e-14 53.7 8.1 3e-14 52.9 8.1 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CDW58695.1 - 0.0051 17.1 8.6 0.011 16.0 8.6 1.6 1 0 0 1 1 1 1 Ring finger domain PDCD7 PF16021.5 CDW58696.1 - 0.032 13.4 1.1 0.032 13.4 1.1 2.6 1 1 1 2 2 2 0 Programmed cell death protein 7 PAP2 PF01569.21 CDW58697.1 - 1.5e-13 50.7 7.6 1.5e-13 50.7 7.6 2.1 2 0 0 2 2 2 1 PAP2 superfamily Wzy_C PF04932.15 CDW58697.1 - 0.35 10.5 2.8 0.95 9.1 0.0 2.4 3 0 0 3 3 3 0 O-Antigen ligase RICTOR_V PF14668.6 CDW58698.1 - 3.2e-13 49.7 0.1 1.1e-12 48.0 0.0 1.9 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 CDW58698.1 - 0.0023 18.3 0.1 0.0061 17.0 0.0 1.8 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEPN_RnaseLS PF18869.1 CDW58698.1 - 0.048 13.8 0.0 0.082 13.0 0.0 1.3 1 0 0 1 1 1 0 RnaseLS-like HEPN DB PF01682.19 CDW58699.1 - 4.4e-15 55.8 8.3 4.4e-15 55.8 8.3 2.3 2 0 0 2 2 2 1 DB module RICTOR_N PF14664.6 CDW58700.1 - 3.5e-33 115.1 2.0 9.5e-33 113.7 2.0 1.7 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 CDW58700.1 - 0.0028 17.4 0.1 0.038 13.8 0.0 2.6 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, middle domain DUF3974 PF13120.6 CDW58700.1 - 0.063 13.4 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3974) DUF4371 PF14291.6 CDW58701.1 - 0.036 13.7 0.1 0.055 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4371) PK PF00224.21 CDW58702.1 - 2.9e-158 526.3 3.7 3.8e-158 525.9 3.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDW58702.1 - 7.6e-30 103.5 0.0 3.4e-29 101.4 0.0 2.2 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CDW58702.1 - 0.00027 20.1 3.8 0.00035 19.8 1.2 2.2 1 1 2 3 3 3 1 HpcH/HpaI aldolase/citrate lyase family TRIF-NTD PF17798.1 CDW58703.1 - 0.082 13.0 0.2 0.2 11.8 0.2 1.6 1 0 0 1 1 1 0 TRIF N-terminal domain AJAP1_PANP_C PF15298.6 CDW58703.1 - 0.21 11.8 5.7 0.39 10.9 5.7 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus SSP160 PF06933.11 CDW58703.1 - 1.8 6.7 10.1 3 5.9 10.1 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 CDW58703.1 - 4.1 5.3 4.4 6.2 4.7 4.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 CDW58703.1 - 5.6 7.0 7.5 11 6.0 7.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) NTP_transf_2 PF01909.23 CDW58704.1 - 0.035 14.4 0.0 0.071 13.4 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain zf-RING_UBOX PF13445.6 CDW58705.1 - 2.9e-08 33.6 10.0 2.9e-08 33.6 10.0 1.8 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW58705.1 - 9.6e-08 31.8 9.2 2e-07 30.8 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 CDW58705.1 - 3.9e-07 29.8 1.8 3.9e-07 29.8 1.8 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_2 PF13923.6 CDW58705.1 - 7.4e-07 28.9 12.4 1.6e-06 27.8 12.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW58705.1 - 3.3e-06 27.0 12.5 6.5e-06 26.0 12.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDW58705.1 - 3.3e-06 26.9 13.5 6.9e-06 25.8 13.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW58705.1 - 1e-05 25.8 11.2 1e-05 25.8 11.2 1.7 2 0 0 2 2 1 1 Ring finger domain zf_CCCH_4 PF18345.1 CDW58705.1 - 6.4e-05 22.9 2.5 6.4e-05 22.9 2.5 2.1 2 0 0 2 2 2 1 Zinc finger domain zf-Nse PF11789.8 CDW58705.1 - 7.5e-05 22.5 9.2 0.00016 21.5 9.2 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 CDW58705.1 - 0.00074 19.6 11.4 0.00074 19.6 11.4 1.9 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-CCCH_4 PF18044.1 CDW58705.1 - 0.0036 17.1 1.7 0.0036 17.1 1.7 2.7 3 0 0 3 3 2 1 CCCH-type zinc finger zf-RING_10 PF16685.5 CDW58705.1 - 0.018 15.1 5.1 0.018 15.1 5.1 1.8 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-CCCH_2 PF14608.6 CDW58705.1 - 0.039 14.4 2.9 0.086 13.3 1.7 2.2 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zinc-ribbons_6 PF07191.12 CDW58705.1 - 0.1 12.6 6.4 0.23 11.5 6.4 1.5 1 0 0 1 1 1 0 zinc-ribbons Prok-RING_4 PF14447.6 CDW58705.1 - 0.14 12.0 11.7 0.81 9.6 11.9 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Triabin PF03973.13 CDW58705.1 - 0.16 11.9 1.8 1.9 8.3 1.5 2.2 2 0 0 2 2 2 0 Triabin zf-RING_11 PF17123.5 CDW58705.1 - 0.32 10.8 5.2 0.73 9.6 5.2 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 CDW58705.1 - 1.2 9.5 8.4 2.7 8.4 8.4 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-P11 PF03854.14 CDW58705.1 - 5.6 6.7 9.0 16 5.2 9.0 1.8 1 1 0 1 1 1 0 P-11 zinc finger PseudoU_synth_2 PF00849.22 CDW58706.1 - 6.8e-28 97.8 0.0 1e-27 97.2 0.0 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF4807 PF16065.5 CDW58707.1 - 2.3e-30 104.8 0.1 2.6e-30 104.7 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4807) zf-H2C2_2 PF13465.6 CDW58708.1 - 3.2e-14 52.6 27.7 2.3e-09 37.3 1.1 5.2 4 1 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 CDW58708.1 - 2.9e-12 46.3 29.1 0.00032 21.0 3.4 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW58708.1 - 8.2e-10 38.7 27.1 0.0015 19.2 0.8 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 CDW58708.1 - 1.8e-06 28.7 9.0 0.013 16.2 0.4 3.4 3 1 1 4 4 3 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 CDW58708.1 - 3.8e-06 26.8 18.7 0.0025 17.8 1.2 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 CDW58708.1 - 0.00021 21.5 16.1 0.0044 17.4 2.1 4.5 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW58708.1 - 0.0065 16.7 11.1 1.4 9.3 0.2 3.9 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 CDW58708.1 - 0.12 12.0 11.2 6.5 6.4 0.2 4.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 CDW58708.1 - 0.34 11.1 15.2 17 5.6 0.1 4.4 3 1 1 4 4 4 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 CDW58708.1 - 0.4 10.4 0.1 0.4 10.4 0.1 2.8 4 0 0 4 4 4 0 Rubredoxin metal binding domain ADK_lid PF05191.14 CDW58708.1 - 0.55 10.3 6.8 0.59 10.2 3.2 2.6 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf_C2H2_ZHX PF18387.1 CDW58708.1 - 0.95 9.2 0.0 0.95 9.2 0.0 3.3 2 1 2 4 4 3 0 Zinc-fingers and homeoboxes C2H2 finger domain FYVE PF01363.21 CDW58708.1 - 1.7 8.8 17.2 2.1 8.6 8.7 2.5 1 1 1 2 2 2 0 FYVE zinc finger FpoO PF10621.9 CDW58708.1 - 1.9 8.9 5.2 2.9 8.3 1.4 2.5 1 1 1 2 2 2 0 F420H2 dehydrogenase subunit FpoO zf-MYST PF17772.1 CDW58708.1 - 5.7 6.6 11.2 11 5.7 0.1 3.9 3 1 1 4 4 4 0 MYST family zinc finger domain Zf_RING PF16744.5 CDW58708.1 - 8.1 6.6 13.5 12 6.1 3.5 2.7 1 1 2 3 3 3 0 KIAA1045 RING finger zf-Di19 PF05605.12 CDW58708.1 - 8.3 6.8 16.3 0.44 10.9 4.5 3.1 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding C1_1 PF00130.22 CDW58708.1 - 9.5 6.2 12.0 1.2 9.1 0.5 3.0 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-H2C2_2 PF13465.6 CDW58709.1 - 4.4e-10 39.5 11.2 2.5e-06 27.6 1.5 4.5 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 CDW58709.1 - 0.00087 19.6 31.4 0.069 13.6 3.9 4.8 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 CDW58709.1 - 0.01 16.1 12.6 0.073 13.4 6.7 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 CDW58709.1 - 0.013 15.4 1.5 0.013 15.4 1.5 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 CDW58709.1 - 0.026 15.3 31.3 0.15 13.0 3.6 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger GGACT PF06094.12 CDW58709.1 - 0.053 14.1 0.0 0.13 12.9 0.0 1.7 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like zf-TRAF PF02176.18 CDW58709.1 - 0.15 12.8 0.4 0.15 12.8 0.4 2.6 2 1 1 3 3 3 0 TRAF-type zinc finger zf-C2H2_jaz PF12171.8 CDW58709.1 - 1.5 9.2 0.0 1.5 9.2 0.0 3.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 CDW58709.1 - 5.6 7.0 9.0 13 5.8 0.0 3.1 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger EGF PF00008.27 CDW58710.1 - 8.9e-44 147.4 151.6 2.4e-07 30.9 9.9 10.8 10 0 0 10 10 10 10 EGF-like domain EGF_CA PF07645.15 CDW58710.1 - 8.7e-30 102.7 169.0 1.3e-09 38.1 11.1 10.5 4 2 6 10 10 10 9 Calcium-binding EGF domain hEGF PF12661.7 CDW58710.1 - 5.1e-21 74.5 133.8 0.00041 20.9 6.8 11.7 10 0 0 10 10 10 9 Human growth factor-like EGF EGF_2 PF07974.13 CDW58710.1 - 1.5e-18 66.9 175.6 0.0025 18.1 11.5 10.6 10 0 0 10 10 10 9 EGF-like domain FXa_inhibition PF14670.6 CDW58710.1 - 1.9e-09 37.6 135.9 0.028 14.7 6.7 10.9 4 3 6 10 10 10 7 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW58710.1 - 6.5e-08 32.6 158.9 0.00017 21.7 12.0 11.5 9 2 1 10 10 10 8 EGF domain Axin_b-cat_bind PF08833.10 CDW58711.1 - 0.068 13.3 0.1 0.12 12.6 0.1 1.3 1 0 0 1 1 1 0 Axin beta-catenin binding domain DUF4817 PF16087.5 CDW58711.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) Sec23_trunk PF04811.15 CDW58712.1 - 4e-72 242.7 0.1 5.5e-72 242.3 0.1 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CDW58712.1 - 2.3e-30 105.2 0.0 4.7e-30 104.2 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CDW58712.1 - 3.1e-25 88.0 0.0 6e-25 87.0 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CDW58712.1 - 2.8e-16 59.3 3.3 7.2e-16 58.0 3.3 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CDW58712.1 - 1.6e-11 44.0 0.0 4.4e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 CDW58712.1 - 0.004 16.5 0.1 0.0085 15.5 0.1 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-MIZ PF02891.20 CDW58712.1 - 0.18 11.5 1.1 0.43 10.4 1.1 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Collagen PF01391.18 CDW58713.1 - 1.7e-20 72.5 104.2 8.5e-10 38.3 35.6 5.5 3 2 1 4 4 4 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW58713.1 - 3e-18 65.6 0.4 3.8e-18 65.3 0.4 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain CBM_14 PF01607.24 CDW58714.1 - 4.7e-108 353.3 232.2 1.5e-12 47.4 1.5 20.7 21 0 0 21 21 21 20 Chitin binding Peritrophin-A domain TIL PF01826.17 CDW58714.1 - 4.6e-08 33.2 16.0 4.6e-08 33.2 16.0 12.4 12 5 4 16 16 16 3 Trypsin Inhibitor like cysteine rich domain RRM_1 PF00076.22 CDW58715.1 - 7.3e-16 57.8 0.0 1.4e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW58715.1 - 1.6e-05 24.5 0.0 1.9e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_6 PF13174.6 CDW58715.1 - 0.0089 16.6 0.4 0.019 15.6 0.4 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat RRM_8 PF11835.8 CDW58715.1 - 0.087 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain DUF2207 PF09972.9 CDW58716.1 - 0.054 12.3 0.1 0.067 11.9 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EGF PF00008.27 CDW58717.1 - 9.9e-42 140.9 163.1 7.5e-08 32.5 9.6 11.0 11 0 0 11 11 11 10 EGF-like domain EGF_CA PF07645.15 CDW58717.1 - 2.4e-28 98.1 167.6 6.9e-10 39.0 9.9 10.5 5 3 5 10 10 10 8 Calcium-binding EGF domain hEGF PF12661.7 CDW58717.1 - 1.6e-20 73.0 135.4 0.00017 22.1 4.7 11.8 11 0 0 11 11 11 9 Human growth factor-like EGF EGF_2 PF07974.13 CDW58717.1 - 2.9e-16 59.5 178.1 0.0017 18.7 11.0 10.6 10 0 0 10 10 10 8 EGF-like domain FXa_inhibition PF14670.6 CDW58717.1 - 3.6e-06 27.1 148.0 0.03 14.6 8.2 10.8 7 2 3 10 10 10 6 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW58717.1 - 6.1e-06 26.3 165.8 0.00011 22.3 11.6 11.1 9 1 1 10 10 10 7 EGF domain cEGF PF12662.7 CDW58717.1 - 0.017 15.1 4.0 0.017 15.1 4.0 12.6 11 3 0 11 11 11 0 Complement Clr-like EGF-like PfkB PF00294.24 CDW58718.1 - 9.2e-27 94.1 0.0 1e-26 94.0 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase NAD_binding_2 PF03446.15 CDW58719.1 - 1.4e-39 135.8 0.5 1.9e-39 135.3 0.5 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CDW58719.1 - 7.1e-25 87.6 0.1 1.2e-24 86.8 0.1 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DeoC PF01791.9 CDW58720.1 - 7.2e-58 196.0 0.1 8.3e-58 195.8 0.1 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase Fibroin_P25 PF07294.11 CDW58720.1 - 0.17 11.9 0.0 0.27 11.3 0.0 1.2 1 0 0 1 1 1 0 Fibroin P25 GlcNAc_2-epim PF07221.11 CDW58721.1 - 1.8e-127 425.4 13.2 2e-127 425.2 13.2 1.0 1 0 0 1 1 1 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_47 PF01532.20 CDW58721.1 - 0.1 11.4 4.3 0.7 8.7 0.1 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 47 Aldose_epim PF01263.20 CDW58722.1 - 3.5e-51 174.3 0.0 4.7e-51 173.9 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Gal_mutarotas_2 PF13802.6 CDW58722.1 - 2.4e-05 24.6 0.3 5.8e-05 23.3 0.0 1.8 2 0 0 2 2 2 1 Galactose mutarotase-like DUF1102 PF06510.11 CDW58722.1 - 0.13 12.4 0.4 2.4 8.3 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1102) Glyco_hydro_31 PF01055.26 CDW58723.1 - 7.4e-74 249.5 2.4 8.8e-74 249.3 2.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 MFS_2 PF13347.6 CDW58724.1 - 5.3e-81 272.4 27.7 6e-81 272.2 27.7 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 CDW58724.1 - 7.7e-11 41.5 43.7 9.4e-10 37.9 27.7 2.8 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 CDW58725.1 - 5.7e-82 275.6 36.5 6.4e-82 275.4 36.5 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 CDW58725.1 - 1.4e-13 50.5 38.9 7.1e-07 28.5 16.7 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_1 PF07690.16 CDW58726.1 - 2.6e-12 46.3 26.2 2.6e-12 46.3 26.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 CDW58726.1 - 2.7 8.3 12.2 0.24 11.7 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) AP_endonuc_2 PF01261.24 CDW58727.1 - 5e-11 42.5 0.1 7.9e-11 41.8 0.1 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel UTRA PF07702.13 CDW58728.1 - 6.4e-21 74.7 0.0 1.2e-20 73.8 0.0 1.5 2 0 0 2 2 2 1 UTRA domain GntR PF00392.21 CDW58728.1 - 8.3e-20 70.2 0.0 1.2e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family GTP_EFTU PF00009.27 CDW58729.1 - 4.7e-58 195.9 0.1 8e-58 195.2 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CDW58729.1 - 1.9e-22 79.1 0.0 5e-22 77.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDW58729.1 - 4.6e-10 39.7 4.1 9.3e-10 38.8 3.3 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW58729.1 - 3.3e-07 30.4 0.4 2.2e-06 27.7 0.1 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase EFG_II PF14492.6 CDW58729.1 - 4.7e-05 23.4 0.2 0.00013 22.0 0.1 1.8 2 0 0 2 2 2 1 Elongation Factor G, domain II Septin PF00735.18 CDW58729.1 - 0.00086 18.7 0.1 0.0014 18.0 0.1 1.2 1 0 0 1 1 1 1 Septin FeoB_N PF02421.18 CDW58729.1 - 0.006 16.1 0.0 0.24 10.9 0.0 3.2 3 1 0 3 3 3 1 Ferrous iron transport protein B SRPRB PF09439.10 CDW58729.1 - 0.076 12.4 0.1 0.21 11.0 0.1 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 CDW58729.1 - 0.12 12.5 0.1 1.7 8.7 0.0 2.4 2 1 0 2 2 2 0 Dynamin family DUF4190 PF13828.6 CDW58729.1 - 0.38 10.5 2.6 0.28 11.0 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) Gln-synt_C PF00120.24 CDW58730.1 - 2.2e-140 467.6 0.0 2.6e-140 467.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CDW58730.1 - 3.6e-32 110.0 0.1 7.4e-32 108.9 0.1 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain HATPase_c PF02518.26 CDW58731.1 - 7.4e-18 65.1 0.0 1.5e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDW58731.1 - 5.5e-14 51.9 0.7 2.5e-13 49.9 0.1 2.5 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS PF00989.25 CDW58731.1 - 9.3e-08 32.1 0.0 3.1e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDW58731.1 - 7.5e-05 22.9 0.0 0.00016 21.9 0.0 1.5 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CDW58731.1 - 8.8e-05 22.7 0.0 0.00019 21.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 CDW58731.1 - 0.00019 21.4 0.1 0.0011 18.9 0.0 2.2 2 0 0 2 2 2 1 PAS domain DUF1688 PF07958.11 CDW58731.1 - 0.037 12.8 0.1 0.047 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) HATPase_c_3 PF13589.6 CDW58731.1 - 0.1 12.4 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sigma54_activat PF00158.26 CDW58732.1 - 7.6e-71 237.2 0.0 1.2e-70 236.6 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDW58732.1 - 3.2e-24 85.6 0.0 2.2e-23 82.9 0.0 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CDW58732.1 - 3.1e-16 59.5 0.0 6.4e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HTH_8 PF02954.19 CDW58732.1 - 8.9e-16 57.4 3.8 2e-15 56.3 1.5 2.4 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family AAA_5 PF07728.14 CDW58732.1 - 6e-08 32.8 0.0 1.3e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDW58732.1 - 2.5e-05 24.5 0.0 4.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CDW58732.1 - 0.00066 20.1 0.0 0.0021 18.5 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 CDW58732.1 - 0.0066 15.8 0.1 0.91 8.9 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDW58732.1 - 0.022 14.3 0.0 0.1 12.1 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region MCM PF00493.23 CDW58732.1 - 0.043 12.9 0.0 0.1 11.7 0.0 1.5 1 1 0 1 1 1 0 MCM P-loop domain AAA_3 PF07726.11 CDW58732.1 - 0.063 13.1 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW58732.1 - 0.084 13.3 0.9 0.28 11.5 0.9 2.2 1 1 0 1 1 1 0 AAA ATPase domain ATP-sulfurylase PF01747.17 CDW58732.1 - 0.093 12.2 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 ATP-sulfurylase Radical_SAM PF04055.21 CDW58733.1 - 5.2e-18 66.0 0.0 8.2e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 CDW58733.1 - 1.9e-08 34.3 0.0 9.6e-08 32.0 0.0 2.4 2 0 0 2 2 2 1 HemN C-terminal domain YihI PF04220.12 CDW58734.1 - 4e-54 182.6 13.1 4e-54 182.6 13.1 1.5 2 0 0 2 2 2 1 Der GTPase activator (YihI) Eapp_C PF10238.9 CDW58734.1 - 0.86 9.7 8.0 0.034 14.2 1.1 2.1 2 1 0 2 2 2 0 E2F-associated phosphoprotein MMR_HSR1 PF01926.23 CDW58735.1 - 2.3e-20 72.8 0.0 2.9e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW58735.1 - 9.9e-07 28.8 0.1 0.00055 19.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CDW58735.1 - 5.7e-05 23.2 0.1 0.099 12.7 0.1 2.3 1 1 1 2 2 2 2 Dynamin family FeoB_N PF02421.18 CDW58735.1 - 0.00016 21.3 0.0 0.00021 20.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B FtsK_SpoIIIE PF01580.18 CDW58735.1 - 0.0067 15.8 0.0 0.0078 15.6 0.0 1.1 1 0 0 1 1 1 1 FtsK/SpoIIIE family SRPRB PF09439.10 CDW58735.1 - 0.018 14.5 0.0 0.036 13.5 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDW58735.1 - 0.022 14.3 0.6 0.41 10.2 0.2 2.2 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 CDW58735.1 - 0.046 14.0 0.0 0.067 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 CDW58735.1 - 0.1 11.9 0.4 3.1 7.0 0.1 2.1 2 1 0 2 2 2 0 Septin PGM_PMM_I PF02878.16 CDW58735.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I DNA_pol_A PF00476.20 CDW58736.1 - 5.6e-161 535.8 0.0 7.4e-161 535.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 CDW58736.1 - 1.9e-55 187.1 0.0 3.6e-55 186.2 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain DNA_pol_A_exo1 PF01612.20 CDW58736.1 - 1.1e-46 158.8 0.1 2.3e-46 157.7 0.1 1.6 1 0 0 1 1 1 1 3'-5' exonuclease 5_3_exonuc PF01367.20 CDW58736.1 - 7.4e-31 106.6 0.0 2.2e-30 105.1 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH PF00633.23 CDW58736.1 - 0.011 15.6 0.1 0.038 13.9 0.1 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif Prok-E2_E PF14462.6 CDW58736.1 - 0.027 14.3 0.0 0.059 13.2 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family E HHH_5 PF14520.6 CDW58736.1 - 0.069 13.8 0.0 0.28 11.8 0.0 2.1 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_2 PF12826.7 CDW58736.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif Acyltransferase PF01553.21 CDW58737.1 - 3.3e-14 52.6 0.0 4.2e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 CDW58737.1 - 0.0044 17.1 1.3 0.01 15.9 0.2 2.2 2 1 0 2 2 2 1 Acyltransferase C-terminus DUF945 PF06097.11 CDW58738.1 - 4.3e-94 316.2 11.3 4.9e-94 316.0 11.3 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF945) DUF5627 PF18620.1 CDW58738.1 - 0.28 11.0 2.0 2.3 8.1 0.0 3.2 4 2 0 4 4 4 0 Family of unknown function (DUF5627) DUF1040 PF06288.13 CDW58739.1 - 5.5e-44 148.4 0.5 1.6e-43 147.0 0.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1040) APH PF01636.23 CDW58739.1 - 2.8e-43 148.6 2.1 5.4e-43 147.6 2.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DSBA PF01323.20 CDW58739.1 - 9.2e-31 107.1 3.7 5.1e-30 104.7 2.5 2.6 2 1 0 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CDW58739.1 - 3.3e-08 33.9 0.0 6.8e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin EcKinase PF02958.20 CDW58739.1 - 0.00037 19.9 0.0 0.0007 19.0 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase Lpp-LpqN PF10738.9 CDW58739.1 - 0.0065 16.0 0.0 0.017 14.6 0.1 1.7 2 0 0 2 2 2 1 Probable lipoprotein LpqN Thioredoxin PF00085.20 CDW58739.1 - 0.023 14.7 0.1 0.98 9.4 0.0 2.7 2 0 0 2 2 2 0 Thioredoxin DUF3088 PF11287.8 CDW58739.1 - 0.29 10.9 1.1 1.3 8.8 0.0 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3088) NTP_transf_3 PF12804.7 CDW58740.1 - 3.9e-35 121.6 0.4 5e-35 121.2 0.4 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 CDW58740.1 - 0.0016 18.2 0.3 0.016 14.9 0.1 2.0 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Abhydrolase_4 PF08386.10 CDW58740.1 - 0.016 15.3 0.0 0.05 13.7 0.0 1.7 2 0 0 2 2 2 0 TAP-like protein MobB PF03205.14 CDW58741.1 - 1.9e-29 102.2 0.1 2.3e-29 102.0 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B UQ_con PF00179.26 CDW58742.1 - 1.1e-19 70.5 0.0 1.7e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDW58742.1 - 0.13 12.5 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 RWD domain zf-met PF12874.7 CDW58742.1 - 0.27 11.7 2.9 0.6 10.6 0.4 2.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Nop14 PF04147.12 CDW58743.1 - 1.4e-107 361.1 25.1 2.2e-68 231.4 4.9 2.0 1 1 1 2 2 2 2 Nop14-like family Acetyltransf_1 PF00583.25 CDW58744.1 - 6.2e-15 55.5 0.0 8.4e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDW58744.1 - 6.3e-09 36.1 0.0 9.7e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDW58744.1 - 4.4e-06 26.9 0.2 1.1e-05 25.6 0.1 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDW58744.1 - 5.3e-06 26.4 0.0 6.7e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW58744.1 - 0.0013 18.7 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 CDW58744.1 - 0.023 14.4 0.0 0.66 9.7 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDW58744.1 - 0.098 12.7 0.0 0.16 12.1 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain RRM_1 PF00076.22 CDW58745.1 - 1.7e-15 56.6 0.0 2.8e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW58745.1 - 0.0044 16.6 0.6 0.013 15.1 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MecA PF05389.12 CDW58745.1 - 0.0095 15.6 1.1 0.011 15.3 1.1 1.1 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) TERB2 PF15101.6 CDW58745.1 - 0.029 14.4 4.5 0.042 13.9 4.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CDC13_N PF16853.5 CDW58745.1 - 0.065 12.8 1.7 0.088 12.3 1.0 1.5 2 0 0 2 2 2 0 Cell division control protein 13 N-terminus Presenilin PF01080.17 CDW58745.1 - 0.37 9.5 2.0 0.43 9.3 2.0 1.1 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 CDW58745.1 - 0.63 9.1 5.8 0.96 8.5 5.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF4834 PF16118.5 CDW58745.1 - 2.7 9.0 5.1 5.1 8.1 5.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Tristanin_u2 PF16638.5 CDW58745.1 - 2.8 8.8 5.8 4.7 8.1 5.8 1.3 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers Spt20 PF12090.8 CDW58745.1 - 3.5 7.2 19.4 5.2 6.6 19.4 1.2 1 0 0 1 1 1 0 Spt20 family GCD14 PF08704.10 CDW58746.1 - 3.3e-73 246.4 0.0 4.2e-73 246.1 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 CDW58746.1 - 0.0052 16.6 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltr_RsmB-F PF01189.17 CDW58746.1 - 0.009 15.7 0.0 0.021 14.5 0.0 1.6 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Vault_4 PF17796.1 CDW58746.1 - 0.069 13.2 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Major Vault Protein repeat domain Methyltransf_31 PF13847.6 CDW58746.1 - 0.12 12.1 0.0 0.26 11.1 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CDW58746.1 - 0.13 12.9 0.1 0.45 11.2 0.0 2.0 1 1 1 2 2 2 0 Methyltransferase domain ELP6 PF09807.9 CDW58747.1 - 3.1e-21 76.0 0.8 6.1e-20 71.7 0.8 2.0 1 1 0 1 1 1 1 Elongation complex protein 6 ATPase PF06745.13 CDW58747.1 - 0.00026 20.4 0.0 0.00031 20.2 0.0 1.1 1 0 0 1 1 1 1 KaiC Elong_Iki1 PF10483.9 CDW58747.1 - 0.0045 16.5 0.0 0.0061 16.1 0.0 1.2 1 0 0 1 1 1 1 Elongator subunit Iki1 MEDS PF14417.6 CDW58747.1 - 0.0095 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain BAT2_N PF07001.11 CDW58748.1 - 2.3e-28 100.0 5.7 2.3e-28 100.0 5.7 1.9 2 0 0 2 2 2 1 BAT2 N-terminus LAX PF15681.5 CDW58748.1 - 0.017 14.0 0.9 0.017 14.0 0.9 1.9 2 0 0 2 2 2 0 Lymphocyte activation family X TTSSLRR PF12468.8 CDW58748.1 - 0.031 14.5 1.2 0.084 13.1 1.2 1.9 1 1 0 1 1 1 0 Type III secretion system leucine rich repeat protein EGF PF00008.27 CDW58749.1 - 1.7e-08 34.6 13.9 9.4e-06 25.8 4.8 2.8 3 1 0 3 3 3 2 EGF-like domain EGF_3 PF12947.7 CDW58749.1 - 7.1e-05 22.9 9.2 0.066 13.4 0.3 2.3 2 0 0 2 2 2 2 EGF domain hEGF PF12661.7 CDW58749.1 - 0.00015 22.3 10.2 0.038 14.6 2.3 3.0 3 1 0 3 3 2 2 Human growth factor-like EGF EGF_CA PF07645.15 CDW58749.1 - 0.00022 21.4 16.5 0.037 14.2 4.4 2.3 1 1 1 2 2 2 2 Calcium-binding EGF domain EGF_2 PF07974.13 CDW58749.1 - 0.0029 17.9 16.5 0.091 13.2 2.4 2.5 2 1 0 2 2 2 2 EGF-like domain FXa_inhibition PF14670.6 CDW58749.1 - 0.0093 16.2 13.6 0.69 10.2 7.4 2.6 1 1 1 2 2 2 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW58749.1 - 0.01 15.7 14.5 0.22 11.5 3.0 2.7 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 CDW58749.1 - 0.022 14.8 8.0 0.25 11.4 2.3 2.4 2 0 0 2 2 2 0 MSP1 EGF domain 1 Laminin_EGF PF00053.24 CDW58749.1 - 0.093 12.9 13.3 1.1 9.5 2.4 2.4 1 1 1 2 2 2 0 Laminin EGF domain Plasmod_Pvs28 PF06247.11 CDW58749.1 - 0.26 11.6 7.9 2.3 8.6 0.6 2.3 1 1 1 2 2 2 0 Pvs28 EGF domain EB PF01683.18 CDW58749.1 - 0.93 9.8 11.9 36 4.7 12.0 2.4 1 1 1 2 2 2 0 EB module EGF PF00008.27 CDW58750.1 - 1.2e-72 239.7 343.7 7.8e-07 29.3 8.4 24.6 24 0 0 24 24 24 23 EGF-like domain hEGF PF12661.7 CDW58750.1 - 2.3e-27 94.6 282.0 7.5e-05 23.2 6.3 26.0 24 0 0 24 24 24 19 Human growth factor-like EGF EGF_2 PF07974.13 CDW58750.1 - 0.0082 16.5 10.3 0.0082 16.5 10.3 24.1 24 0 0 24 24 24 16 EGF-like domain EGF_3 PF12947.7 CDW58750.1 - 0.015 15.5 2.9 0.015 15.5 2.9 24.5 22 2 2 24 24 24 0 EGF domain DUF1725 PF08333.11 CDW58750.1 - 2.2 8.0 4.6 62 3.4 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1725) DUF5641 PF18701.1 CDW58752.1 - 9.3e-13 48.2 0.6 1e-12 48.1 0.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5641) TagF_N PF09867.9 CDW58752.1 - 0.042 13.9 0.2 0.043 13.8 0.2 1.1 1 0 0 1 1 1 0 TagF N-terminal domain, Type VI secretion system-associated EGF PF00008.27 CDW58753.1 - 2.1e-06 27.9 14.8 5.2e-06 26.7 6.2 2.4 2 0 0 2 2 2 2 EGF-like domain EGF_2 PF07974.13 CDW58753.1 - 3.4e-06 27.3 20.7 0.00066 20.0 9.0 2.3 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 CDW58753.1 - 4.1e-05 24.0 8.4 4.1e-05 24.0 8.4 2.9 3 1 0 3 3 3 1 Human growth factor-like EGF DSL PF01414.19 CDW58753.1 - 0.04 14.2 12.1 0.065 13.5 12.1 1.3 1 0 0 1 1 1 0 Delta serrate ligand Laminin_EGF PF00053.24 CDW58753.1 - 0.069 13.3 14.5 0.74 10.0 1.4 2.3 1 1 1 2 2 2 0 Laminin EGF domain FXa_inhibition PF14670.6 CDW58753.1 - 1.3 9.4 13.8 23 5.4 7.0 2.5 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW58753.1 - 3.6 7.9 16.0 1.4 9.2 6.5 2.4 2 1 0 2 2 2 0 EGF domain ALIX_LYPXL_bnd PF13949.6 CDW58755.1 - 1.2e-81 274.2 10.8 1.7e-81 273.8 10.8 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF4140 PF13600.6 CDW58755.1 - 0.15 12.5 9.5 0.64 10.5 0.4 3.3 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) ApoLp-III PF07464.11 CDW58755.1 - 0.16 12.0 13.0 0.29 11.2 3.4 3.2 1 1 2 3 3 3 0 Apolipophorin-III precursor (apoLp-III) LUC7 PF03194.15 CDW58755.1 - 0.46 10.1 5.3 0.75 9.4 5.3 1.5 1 0 0 1 1 1 0 LUC7 N_terminus Seryl_tRNA_N PF02403.22 CDW58755.1 - 9.8 6.5 10.9 17 5.7 1.3 3.0 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain His_Phos_2 PF00328.22 CDW58756.1 - 2.7e-22 79.6 1.7 1.7e-14 54.0 0.1 3.0 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Shisa PF13908.6 CDW58756.1 - 0.059 13.6 0.9 0.084 13.1 0.9 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF1180 PF06679.12 CDW58756.1 - 0.17 12.3 0.2 0.26 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF1681 PF07933.14 CDW58757.1 - 5.4e-46 156.0 0.0 7.9e-46 155.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) UQ_con PF00179.26 CDW58757.1 - 9.1e-19 67.5 0.0 1.4e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LIM PF00412.22 CDW58759.1 - 6.4e-31 106.4 19.0 3.1e-16 59.4 5.1 2.2 2 0 0 2 2 2 2 LIM domain Homeodomain PF00046.29 CDW58759.1 - 4.1e-20 71.4 2.0 6.7e-20 70.7 2.0 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW58759.1 - 1.3e-05 25.0 0.1 2.9e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain zf-C2H2_4 PF13894.6 CDW58759.1 - 0.12 13.2 9.9 1.7 9.7 0.1 4.0 3 0 0 3 3 3 0 C2H2-type zinc finger C1_1 PF00130.22 CDW58759.1 - 0.5 10.3 16.7 0.066 13.1 2.2 3.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Band_7 PF01145.25 CDW58760.1 - 1.7e-21 77.0 1.5 1.7e-21 77.0 1.5 1.8 2 1 0 2 2 2 1 SPFH domain / Band 7 family Med2 PF11214.8 CDW58760.1 - 0.0054 16.9 0.9 0.011 15.9 0.9 1.5 1 0 0 1 1 1 1 Mediator complex subunit 2 PIP5K PF01504.18 CDW58761.1 - 1.6e-86 289.9 0.0 2.6e-86 289.3 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PatG_C PF18065.1 CDW58761.1 - 0.054 13.5 0.5 0.11 12.5 0.1 1.6 2 0 0 2 2 2 0 PatG C-terminal Glycos_transf_2 PF00535.26 CDW58764.1 - 6.3e-27 94.5 0.0 9.9e-27 93.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 CDW58764.1 - 4.5e-24 85.1 0.8 9.4e-24 84.1 0.8 1.6 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 CDW58764.1 - 3.7e-05 23.7 0.0 9.5e-05 22.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 CDW58764.1 - 6.9e-05 22.4 0.0 0.0002 21.0 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDW58764.1 - 0.0062 16.0 0.0 0.048 13.1 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7N PF13733.6 CDW58764.1 - 0.053 13.2 0.0 0.098 12.3 0.0 1.4 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 CDtoxinA PF03498.14 CDW58764.1 - 0.097 12.3 0.2 18 4.9 0.0 2.7 2 0 0 2 2 2 0 Cytolethal distending toxin A/C domain Fcf1 PF04900.12 CDW58765.1 - 5.9e-36 122.8 1.9 7.3e-36 122.5 1.9 1.1 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 CDW58765.1 - 1.1e-11 45.1 0.0 1.3e-11 44.8 0.0 1.1 1 0 0 1 1 1 1 PIN like domain DUF116 PF01976.17 CDW58765.1 - 0.04 13.4 2.1 0.068 12.7 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF116 Pkinase PF00069.25 CDW58766.1 - 5.8e-64 216.0 0.0 7.4e-64 215.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58766.1 - 2.7e-31 108.8 0.0 5.6e-31 107.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW58766.1 - 0.0018 17.3 0.6 0.0032 16.5 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 CDW58766.1 - 0.0043 16.4 0.0 0.0088 15.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 CDW58766.1 - 0.0062 15.9 0.1 0.014 14.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW58766.1 - 0.017 15.0 0.5 0.036 14.0 0.5 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Laminin_I PF06008.14 CDW58767.1 - 0.00056 19.7 0.6 0.95 9.1 0.4 2.4 1 1 1 2 2 2 2 Laminin Domain I DUF4686 PF15742.5 CDW58767.1 - 0.02 14.0 0.9 0.04 13.1 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) GCN5L1 PF06320.13 CDW58767.1 - 0.044 13.9 0.7 0.25 11.5 0.1 2.4 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) AP3D1 PF06375.11 CDW58768.1 - 3.2e-12 47.0 4.8 1.6e-11 44.7 4.8 1.8 1 1 0 1 1 1 1 AP-3 complex subunit delta-1 Adaptin_N PF01602.20 CDW58768.1 - 1.2e-09 37.3 0.0 1.5e-09 37.0 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Misat_Tub_SegII PF10644.9 CDW58769.1 - 3.1e-16 59.7 0.0 6.5e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 CDW58769.1 - 4.4e-08 33.0 0.0 9.5e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Aa_trans PF01490.18 CDW58770.1 - 1.1e-41 143.0 25.4 1.3e-41 142.7 25.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein zf-C2H2 PF00096.26 CDW58772.1 - 8.8e-16 57.4 28.6 1.2e-06 28.7 1.6 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW58772.1 - 1.8e-15 56.6 22.3 3.4e-07 30.4 3.1 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW58772.1 - 5.6e-13 48.5 19.8 9.6e-05 22.9 0.9 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger NOA36 PF06524.12 CDW58772.1 - 3e-08 33.4 20.6 5.6e-08 32.5 20.6 1.3 1 0 0 1 1 1 1 NOA36 protein zf-C2H2_11 PF16622.5 CDW58772.1 - 1.6e-07 31.0 14.8 0.00047 19.8 1.2 3.4 3 0 0 3 3 3 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 CDW58772.1 - 1.1e-05 25.3 13.8 0.0011 18.9 0.3 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW58772.1 - 1.3e-05 25.4 8.4 0.095 13.0 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 CDW58772.1 - 4e-05 23.3 27.5 0.026 14.3 0.2 4.6 4 1 0 4 4 3 3 C2H2-type zinc-finger domain zf-Di19 PF05605.12 CDW58772.1 - 0.00032 20.9 9.1 0.006 16.8 5.3 2.4 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding DUF4428 PF14471.6 CDW58772.1 - 0.00039 20.3 0.2 0.0038 17.1 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4428) zf-BED PF02892.15 CDW58772.1 - 0.0007 19.6 15.7 0.025 14.6 0.3 3.5 1 1 2 3 3 3 2 BED zinc finger RNA_pol_3_Rpc31 PF11705.8 CDW58772.1 - 0.0011 19.2 8.2 0.0017 18.7 8.2 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 GAGA PF09237.11 CDW58772.1 - 0.0023 17.7 13.4 0.011 15.5 1.2 3.2 1 1 2 3 3 3 2 GAGA factor zf-C2H2_2 PF12756.7 CDW58772.1 - 0.003 17.9 8.3 0.65 10.4 0.0 3.2 1 1 2 3 3 3 1 C2H2 type zinc-finger (2 copies) Myc_N PF01056.18 CDW58772.1 - 0.099 12.5 9.3 0.15 11.9 9.3 1.3 1 0 0 1 1 1 0 Myc amino-terminal region zf-met PF12874.7 CDW58772.1 - 0.13 12.7 11.0 0.62 10.5 0.1 3.1 3 0 0 3 3 2 0 Zinc-finger of C2H2 type SDA1 PF05285.12 CDW58772.1 - 0.17 11.3 21.5 0.28 10.6 21.5 1.2 1 0 0 1 1 1 0 SDA1 DUF5529 PF17669.1 CDW58772.1 - 0.3 11.1 2.0 0.47 10.5 2.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5529) PPP4R2 PF09184.11 CDW58772.1 - 0.31 10.6 19.5 0.55 9.8 19.5 1.4 1 0 0 1 1 1 0 PPP4R2 PyrI_C PF02748.15 CDW58772.1 - 0.37 10.7 12.2 0.76 9.7 2.7 3.5 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Cwf_Cwc_15 PF04889.12 CDW58772.1 - 0.41 10.3 16.6 0.7 9.6 16.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 CDW58772.1 - 0.79 7.7 21.4 1 7.4 21.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Fer4_10 PF13237.6 CDW58772.1 - 1.9 8.7 6.4 2.5 8.3 4.2 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain Nop14 PF04147.12 CDW58772.1 - 1.9 6.6 22.9 2.6 6.1 22.9 1.1 1 0 0 1 1 1 0 Nop14-like family zf-MYST PF17772.1 CDW58772.1 - 3.6 7.3 7.6 3.6 7.3 0.0 3.1 2 1 1 3 3 3 0 MYST family zinc finger domain PA26 PF04636.13 CDW58772.1 - 3.9 6.3 6.1 5.4 5.8 6.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4820 PF16091.5 CDW58772.1 - 3.9 6.8 7.1 7.1 5.9 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) zf-C2H2_3rep PF18868.1 CDW58772.1 - 4.8 7.9 13.5 2.8 8.6 0.3 3.5 1 1 3 4 4 4 0 Zinc finger C2H2-type, 3 repeats CDC45 PF02724.14 CDW58772.1 - 5.3 5.2 18.4 7.4 4.7 18.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 CDW58772.1 - 6.8 5.7 23.2 11 5.0 23.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF913 PF06025.12 CDW58772.1 - 7.3 5.5 6.1 10 5.0 6.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Sigma70_ner PF04546.13 CDW58772.1 - 9.4 6.0 19.0 17 5.2 19.0 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region PP28 PF10252.9 CDW58773.1 - 0.019 15.4 0.7 0.021 15.3 0.7 1.2 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 Hist_deacetyl PF00850.19 CDW58774.1 - 3.1e-64 217.4 0.0 4.1e-64 217.0 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Peptidase_C3G PF12381.8 CDW58774.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Tungro spherical virus-type peptidase zf-Tim10_DDP PF02953.15 CDW58775.1 - 2.3e-20 72.0 1.0 3.2e-20 71.5 1.0 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PAZ_siRNAbind PF12212.8 CDW58775.1 - 0.057 13.3 0.0 0.066 13.0 0.0 1.0 1 0 0 1 1 1 0 PAZ domain MMACHC PF16690.5 CDW58776.1 - 7.7e-74 248.0 0.0 9.4e-74 247.7 0.0 1.0 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type C family Histone PF00125.24 CDW58777.1 - 1.6e-46 157.9 2.4 1.8e-46 157.7 2.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW58777.1 - 0.00034 21.2 3.5 0.00045 20.8 3.5 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW58777.1 - 0.0011 19.1 1.3 0.0012 18.9 0.1 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW58777.1 - 0.02 15.3 0.1 0.03 14.7 0.1 1.3 1 0 0 1 1 1 0 CENP-S protein TFIID-31kDa PF02291.15 CDW58777.1 - 0.023 14.8 0.3 0.046 13.8 0.1 1.7 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Sirohm_synth_M PF14824.6 CDW58777.1 - 3.4 7.2 5.2 4.7 6.8 0.4 2.5 2 0 0 2 2 2 0 Sirohaem biosynthesis protein central Pkinase PF00069.25 CDW58779.1 - 9.3e-58 195.7 0.5 3.9e-57 193.6 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58779.1 - 4.8e-42 144.0 0.8 9e-42 143.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase PKK PF12474.8 CDW58779.1 - 6e-40 136.6 72.4 4.2e-24 85.3 27.3 4.8 2 2 3 5 5 5 2 Polo kinase kinase Helitron_like_N PF14214.6 CDW58780.1 - 9.4e-29 101.0 0.0 2.2e-27 96.5 0.0 2.6 1 1 0 1 1 1 1 Helitron helicase-like domain at N-terminus VioE PF18234.1 CDW58780.1 - 0.028 14.6 0.3 3.5 7.7 0.0 2.6 3 0 0 3 3 3 0 Violacein biosynthetic enzyme VioE DUF2156 PF09924.9 CDW58781.1 - 2.6e-82 276.2 0.0 3.3e-82 275.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) LPG_synthase_TM PF03706.13 CDW58781.1 - 9.6e-10 38.5 14.3 4.1e-09 36.4 9.6 2.4 2 0 0 2 2 2 2 Lysylphosphatidylglycerol synthase TM region FSH1 PF03959.13 CDW58781.1 - 0.018 14.7 0.0 6.4 6.4 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 CDW58781.1 - 0.036 13.7 0.0 0.08 12.6 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Lysozyme_like PF13702.6 CDW58782.1 - 9.3e-53 178.2 11.4 2.1e-52 177.0 11.4 1.6 1 0 0 1 1 1 1 Lysozyme-like Toprim_N PF08275.11 CDW58782.1 - 2.8e-40 137.3 0.1 7.8e-40 135.9 0.1 1.8 1 0 0 1 1 1 1 DNA primase catalytic core, N-terminal domain zf-CHC2 PF01807.20 CDW58782.1 - 2.2e-39 133.2 0.1 4.9e-39 132.1 0.1 1.6 1 0 0 1 1 1 1 CHC2 zinc finger Toprim_2 PF13155.6 CDW58782.1 - 3.1e-16 59.6 0.0 1.2e-15 57.6 0.0 2.1 2 0 0 2 2 2 1 Toprim-like Toprim_4 PF13662.6 CDW58782.1 - 1.3e-13 51.2 0.1 3.5e-13 49.8 0.1 1.8 1 0 0 1 1 1 1 Toprim domain DnaB_bind PF10410.9 CDW58782.1 - 8.5e-10 38.7 0.2 6.2e-09 35.9 0.0 2.4 2 0 0 2 2 2 1 DnaB-helicase binding domain of primase Toprim_3 PF13362.6 CDW58782.1 - 2.2e-06 27.9 0.1 7e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 Toprim domain Toprim PF01751.22 CDW58782.1 - 0.011 16.0 0.1 0.079 13.2 0.0 2.4 2 0 0 2 2 2 0 Toprim domain Sigma70_r3 PF04539.16 CDW58783.1 - 1.1e-31 108.8 1.8 1.1e-31 108.8 1.8 3.0 3 0 0 3 3 3 1 Sigma-70 region 3 Sigma70_r4 PF04545.16 CDW58783.1 - 7.4e-24 83.0 5.6 9.9e-20 69.8 2.2 2.9 2 0 0 2 2 2 2 Sigma-70, region 4 Sigma70_r2 PF04542.14 CDW58783.1 - 8.2e-23 80.0 0.3 1.6e-22 79.0 0.3 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r1_2 PF00140.20 CDW58783.1 - 4.7e-17 61.7 1.2 4.7e-17 61.7 1.2 2.2 2 0 0 2 2 2 1 Sigma-70 factor, region 1.2 Sigma70_r1_1 PF03979.14 CDW58783.1 - 3.8e-12 46.1 5.4 1.3e-11 44.4 1.9 2.5 2 0 0 2 2 2 1 Sigma-70 factor, region 1.1 Exonuc_VII_L PF02601.15 CDW58783.1 - 0.034 13.7 1.4 0.065 12.8 0.0 1.9 2 1 0 2 2 2 0 Exonuclease VII, large subunit Glyco_trans_4_5 PF16994.5 CDW58783.1 - 0.075 12.6 0.7 7.5 6.1 0.1 2.2 1 1 1 2 2 2 0 Glycosyl-transferase family 4 PolyA_pol_arg_C PF12626.7 CDW58783.1 - 0.28 11.2 2.9 0.27 11.3 0.7 2.1 2 0 0 2 2 2 0 Polymerase A arginine-rich C-terminus B12-binding_2 PF02607.17 CDW58783.1 - 1.8 9.1 4.8 22 5.6 0.2 3.3 4 0 0 4 4 4 0 B12 binding domain MapZ_C2 PF18708.1 CDW58784.1 - 1.6e-41 140.5 0.2 4.9e-41 138.9 0.2 1.9 1 0 0 1 1 1 1 MapZ extracellular C-terminal domain 2 MapZ_EC1 PF18041.1 CDW58784.1 - 6e-30 104.1 10.2 6e-30 104.1 10.2 3.6 2 1 1 3 3 3 1 MapZ extracellular domain 1 UPF0547 PF10571.9 CDW58784.1 - 0.011 15.8 3.8 0.22 11.6 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-ribbon_3 PF13248.6 CDW58784.1 - 0.015 14.6 6.4 0.03 13.7 6.4 1.5 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 CDW58784.1 - 0.018 14.8 10.0 0.04 13.7 10.0 1.7 1 0 0 1 1 1 0 zinc-ribbon domain SelB-wing_1 PF09105.10 CDW58784.1 - 0.052 13.5 0.0 0.28 11.2 0.0 2.2 2 0 0 2 2 2 0 Elongation factor SelB, winged helix Ribosomal_L32p PF01783.23 CDW58784.1 - 0.075 13.3 1.0 0.19 12.0 1.0 1.6 1 0 0 1 1 1 0 Ribosomal L32p protein family DZR PF12773.7 CDW58784.1 - 0.078 13.0 5.2 0.16 12.0 5.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon HC2 PF07382.11 CDW58784.1 - 0.19 11.8 12.7 0.34 11.0 12.7 1.3 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 OrfB_Zn_ribbon PF07282.11 CDW58784.1 - 0.31 11.0 1.7 0.98 9.4 1.7 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 CDW58784.1 - 0.72 9.4 5.1 2.6 7.6 5.1 2.0 1 0 0 1 1 1 0 TFIIB zinc-binding CvfB_WH PF17783.1 CDW58785.1 - 7.3e-24 83.3 0.0 1.3e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 CvfB-like winged helix domain S1_2 PF13509.6 CDW58785.1 - 4.9e-06 26.5 0.6 1.7e-05 24.7 0.6 2.0 1 0 0 1 1 1 1 S1 domain S1 PF00575.23 CDW58785.1 - 0.00036 20.8 1.9 0.083 13.2 0.0 3.1 3 1 0 3 3 3 2 S1 RNA binding domain MarR_2 PF12802.7 CDW58785.1 - 0.02 14.8 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 MarR family DUF4423 PF14394.6 CDW58785.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Phage_integrase PF00589.22 CDW58786.1 - 1.7e-52 177.7 0.1 2.4e-52 177.2 0.1 1.2 1 0 0 1 1 1 1 Phage integrase family Phage_int_SAM_1 PF02899.17 CDW58786.1 - 2.6e-22 78.9 4.1 3.5e-22 78.5 2.2 2.1 2 1 0 2 2 2 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_4 PF13495.6 CDW58786.1 - 8.3e-05 23.0 3.1 8.6e-05 22.9 0.7 2.3 3 1 0 3 3 3 1 Phage integrase, N-terminal SAM-like domain Phage_int_SAM_5 PF13102.6 CDW58786.1 - 0.0075 16.6 0.5 1.3 9.4 0.0 2.9 2 1 1 3 3 3 1 Phage integrase SAM-like domain SMC_ScpA PF02616.14 CDW58787.1 - 2.2e-43 148.9 7.6 3.1e-43 148.4 7.6 1.2 1 0 0 1 1 1 1 Segregation and condensation protein ScpA PseudoU_synth_2 PF00849.22 CDW58788.1 - 6.2e-24 84.9 0.1 1.2e-23 84.0 0.1 1.5 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDW58788.1 - 1e-14 53.9 0.8 2.4e-14 52.8 0.8 1.7 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CDW58788.1 - 7.9e-05 22.4 0.8 0.00017 21.4 0.8 1.6 1 0 0 1 1 1 1 S4 domain Cytidylate_kin PF02224.18 CDW58789.1 - 4.1e-49 167.2 1.8 9.1e-49 166.0 1.8 1.5 1 0 0 1 1 1 1 Cytidylate kinase Helicase_C PF00271.31 CDW58789.1 - 4e-21 75.4 0.8 6.2e-21 74.8 0.0 1.8 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW58789.1 - 0.00034 20.4 0.0 0.0052 16.6 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase LysM PF01476.20 CDW58789.1 - 0.0006 19.8 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 LysM domain Utp14 PF04615.13 CDW58789.1 - 0.0021 16.8 11.0 0.0037 15.9 10.8 1.5 2 0 0 2 2 2 1 Utp14 protein Presenilin PF01080.17 CDW58789.1 - 0.0057 15.5 7.9 0.0057 15.5 7.9 1.6 2 0 0 2 2 2 1 Presenilin Orf78 PF06024.12 CDW58789.1 - 0.0063 16.8 3.7 0.16 12.3 0.0 2.9 1 1 1 2 2 1 1 Orf78 (ac78) SpoIIIAH PF12685.7 CDW58789.1 - 0.0067 16.3 16.3 0.0067 16.3 16.3 1.8 2 0 0 2 2 1 1 SpoIIIAH-like protein G6B PF15096.6 CDW58789.1 - 0.0069 16.2 1.3 0.013 15.3 0.5 1.9 2 0 0 2 2 1 1 G6B family Cytidylate_kin2 PF13189.6 CDW58789.1 - 0.014 15.5 0.2 0.014 15.5 0.2 2.4 2 0 0 2 2 1 0 Cytidylate kinase-like family SDA1 PF05285.12 CDW58789.1 - 0.03 13.8 12.0 0.064 12.7 12.0 1.5 1 0 0 1 1 1 0 SDA1 SOG2 PF10428.9 CDW58789.1 - 0.046 12.9 11.6 0.067 12.4 11.6 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SAPS PF04499.15 CDW58789.1 - 0.078 11.8 7.8 0.12 11.1 7.8 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Peptidase_S64 PF08192.11 CDW58789.1 - 0.086 11.3 9.1 0.12 10.8 9.1 1.2 1 0 0 1 1 1 0 Peptidase family S64 Zip PF02535.22 CDW58789.1 - 0.095 11.9 1.4 0.14 11.3 1.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter LRRC37AB_C PF14914.6 CDW58789.1 - 0.19 11.7 0.0 0.19 11.7 0.0 2.6 2 0 0 2 2 1 0 LRRC37A/B like protein 1 C-terminal domain Hid1 PF12722.7 CDW58789.1 - 0.31 9.1 11.9 0.42 8.7 11.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CLN3 PF02487.17 CDW58789.1 - 0.54 9.3 3.6 0.96 8.4 3.6 1.4 1 0 0 1 1 1 0 CLN3 protein CSG2 PF16965.5 CDW58789.1 - 0.58 9.0 1.9 0.88 8.4 1.9 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator MCM_bind PF09739.9 CDW58789.1 - 0.68 8.3 9.3 1.5 7.2 9.3 1.5 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor V_ATPase_I PF01496.19 CDW58789.1 - 1.2 6.9 6.9 0.15 9.9 1.5 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Suf PF05843.14 CDW58789.1 - 1.3 9.0 8.8 2.7 7.9 8.8 1.6 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SOBP PF15279.6 CDW58789.1 - 1.3 9.5 10.0 2.5 8.6 10.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Coilin_N PF15862.5 CDW58789.1 - 1.5 8.7 14.4 2 8.2 12.9 2.0 1 1 0 1 1 1 0 Coilin N-terminus GREB1 PF15782.5 CDW58789.1 - 1.6 5.7 11.1 2.1 5.4 11.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pannexin_like PF12534.8 CDW58789.1 - 3.1 6.8 6.9 6.5 5.7 6.9 1.6 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 CPSF100_C PF13299.6 CDW58789.1 - 3.8 7.7 8.6 10 6.2 8.6 1.8 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal tRNA_anti-like PF12869.7 CDW58789.1 - 5.2 6.7 9.4 84 2.7 9.4 2.5 1 1 0 1 1 1 0 tRNA_anti-like Macoilin PF09726.9 CDW58789.1 - 5.4 5.4 14.7 12 4.3 14.7 1.5 1 0 0 1 1 1 0 Macoilin family S1 PF00575.23 CDW58790.1 - 1.8e-71 236.5 23.6 4.6e-24 84.6 0.8 4.2 4 0 0 4 4 4 4 S1 RNA binding domain S1_2 PF13509.6 CDW58790.1 - 2e-06 27.8 9.0 0.091 12.8 0.1 5.9 5 3 0 5 5 5 2 S1 domain RNase_II_C_S1 PF18614.1 CDW58790.1 - 4.6e-05 23.3 1.6 0.097 12.6 0.0 3.1 3 0 0 3 3 3 2 RNase II-type exonuclease C-terminal S1 domain DUF2110 PF09883.9 CDW58790.1 - 0.0028 17.3 4.0 2.4 7.7 0.2 3.8 1 1 2 4 4 4 2 Uncharacterized protein conserved in archaea (DUF2110) CsrA PF02599.16 CDW58790.1 - 0.024 14.6 9.6 0.97 9.4 0.0 3.8 4 0 0 4 4 4 0 Global regulator protein family TOBE_2 PF08402.10 CDW58790.1 - 0.041 14.0 0.7 0.51 10.5 0.0 2.6 1 1 1 2 2 2 0 TOBE domain Ribosomal_L19 PF01245.20 CDW58790.1 - 0.042 13.8 4.3 2 8.4 0.0 3.7 4 0 0 4 4 4 0 Ribosomal protein L19 RuvA_N PF01330.21 CDW58790.1 - 0.1 12.7 7.6 1.7 8.8 0.4 3.6 4 0 0 4 4 4 0 RuvA N terminal domain DUF3006 PF11213.8 CDW58790.1 - 0.41 10.9 7.6 2.4 8.4 0.5 4.6 5 1 0 5 5 5 0 Protein of unknown function (DUF3006) NusA_N PF08529.11 CDW58790.1 - 4.2 7.8 8.5 25 5.2 0.3 3.9 2 2 1 3 3 3 0 NusA N-terminal domain MMR_HSR1 PF01926.23 CDW58791.1 - 6.6e-54 180.9 1.0 8.5e-26 90.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Bac_DNA_binding PF00216.21 CDW58791.1 - 4.2e-32 110.2 0.3 1.1e-31 108.9 0.3 1.7 1 0 0 1 1 1 1 Bacterial DNA-binding protein FeoB_N PF02421.18 CDW58791.1 - 2.1e-23 82.6 0.3 1.1e-10 41.2 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 CDW58791.1 - 1.2e-20 73.8 1.7 1.8e-08 34.2 0.5 4.7 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain AIG1 PF04548.16 CDW58791.1 - 6.3e-15 55.1 0.1 3.1e-06 26.7 0.1 2.6 2 0 0 2 2 2 2 AIG1 family Dynamin_N PF00350.23 CDW58791.1 - 1.5e-12 47.9 8.3 0.0041 17.2 0.0 5.4 4 2 2 6 6 6 4 Dynamin family RsgA_GTPase PF03193.16 CDW58791.1 - 3.6e-09 36.7 8.0 0.012 15.5 0.2 4.7 5 1 0 5 5 5 3 RsgA GTPase HU-HIG PF18291.1 CDW58791.1 - 2.5e-08 34.1 0.1 1.1e-07 31.9 0.0 2.1 2 0 0 2 2 1 1 HU domain fused to wHTH, Ig, or Glycine-rich motif KH_dom-like PF14714.6 CDW58791.1 - 7.9e-08 32.5 0.0 5.7e-07 29.7 0.0 2.3 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal PduV-EutP PF10662.9 CDW58791.1 - 3.9e-07 29.9 0.3 0.0007 19.4 0.0 3.2 2 2 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 CDW58791.1 - 2.1e-06 28.0 6.7 0.0028 17.9 0.0 3.5 4 1 0 4 4 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CDW58791.1 - 4.6e-05 23.1 0.7 0.22 11.1 0.3 3.0 2 1 0 2 2 2 2 Ras family SRPRB PF09439.10 CDW58791.1 - 7.9e-05 22.2 0.3 0.21 11.0 0.0 2.7 3 0 0 3 3 3 2 Signal recognition particle receptor beta subunit AAA_24 PF13479.6 CDW58791.1 - 0.00013 21.8 0.0 0.16 11.6 0.0 2.9 2 0 0 2 2 2 2 AAA domain HU-CCDC81_euk_2 PF18289.1 CDW58791.1 - 0.00015 21.8 0.1 0.00031 20.8 0.1 1.4 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 2 ABC_tran PF00005.27 CDW58791.1 - 0.00016 22.2 8.9 0.12 12.9 0.3 3.7 3 1 0 3 3 3 2 ABC transporter HU-CCDC81_bac_2 PF18175.1 CDW58791.1 - 0.0014 18.4 0.0 0.0046 16.8 0.0 1.9 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 RNA_helicase PF00910.22 CDW58791.1 - 0.0016 18.8 0.0 4.2 7.8 0.0 3.0 2 1 0 2 2 2 2 RNA helicase DUF2267 PF10025.9 CDW58791.1 - 0.0017 18.6 0.3 0.0073 16.6 0.1 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2267) AAA PF00004.29 CDW58791.1 - 0.0019 18.6 1.0 1.7 9.1 0.0 3.6 3 2 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CDW58791.1 - 0.0063 16.2 0.0 3.8 7.3 0.0 2.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain Nuc_deoxyrib_tr PF05014.15 CDW58791.1 - 0.0084 16.1 3.8 0.24 11.4 0.1 2.8 3 0 0 3 3 2 1 Nucleoside 2-deoxyribosyltransferase EF-hand_5 PF13202.6 CDW58791.1 - 0.017 14.6 0.0 0.047 13.2 0.0 1.8 1 0 0 1 1 1 0 EF hand Arf PF00025.21 CDW58791.1 - 0.022 14.2 0.6 0.85 9.1 0.0 2.9 2 2 0 2 2 2 0 ADP-ribosylation factor family AAA_22 PF13401.6 CDW58791.1 - 0.028 14.7 0.0 15 5.8 0.0 3.9 4 0 0 4 4 4 0 AAA domain NTPase_1 PF03266.15 CDW58791.1 - 0.035 14.0 1.4 2.1 8.2 0.0 3.6 4 0 0 4 4 4 0 NTPase NB-ARC PF00931.22 CDW58791.1 - 0.036 13.3 0.0 4.9 6.3 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain EF-hand_1 PF00036.32 CDW58791.1 - 0.068 12.7 0.0 0.2 11.3 0.0 1.9 1 0 0 1 1 1 0 EF hand AAA_18 PF13238.6 CDW58791.1 - 0.094 13.3 0.0 3 8.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF4258 PF14076.6 CDW58791.1 - 0.099 13.0 1.8 1.7 9.1 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4258) cobW PF02492.19 CDW58791.1 - 0.15 11.6 7.1 0.3 10.6 0.1 3.8 3 2 1 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 CDW58791.1 - 0.89 9.4 5.5 4.4 7.2 0.1 3.4 2 2 0 3 3 3 0 ATPase domain predominantly from Archaea TPR_19 PF14559.6 CDW58792.1 - 1.7e-22 79.7 37.4 4.8e-05 23.8 0.7 7.8 3 2 7 10 10 10 8 Tetratricopeptide repeat TPR_14 PF13428.6 CDW58792.1 - 6.7e-21 73.2 28.2 0.00047 20.8 0.3 10.3 4 2 7 11 11 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 CDW58792.1 - 1.1e-20 72.0 37.1 1.3e-05 24.9 0.2 11.2 11 1 1 12 12 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDW58792.1 - 1.3e-17 64.1 21.5 8.2e-05 23.2 0.5 7.7 5 2 3 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDW58792.1 - 6.5e-15 55.2 33.9 1.8e-06 28.1 0.1 8.9 3 3 6 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 CDW58792.1 - 2.1e-14 52.4 37.3 0.0061 16.7 0.1 10.3 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDW58792.1 - 2e-10 40.1 32.3 0.00032 20.4 0.3 8.0 8 1 1 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW58792.1 - 2.5e-09 37.2 14.8 0.0049 17.1 1.1 5.9 2 2 4 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CDW58792.1 - 2.2e-08 34.2 25.5 0.031 14.9 0.2 9.3 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDW58792.1 - 1.5e-07 30.9 21.7 0.045 13.8 0.5 7.6 9 1 0 9 9 7 2 Tetratricopeptide repeat TPR_21 PF09976.9 CDW58792.1 - 2.9e-05 23.9 11.2 0.37 10.5 0.0 3.4 2 2 1 3 3 3 2 Tetratricopeptide repeat-like domain DUF3808 PF10300.9 CDW58792.1 - 4.1e-05 22.5 2.0 0.11 11.3 0.0 2.7 2 1 1 3 3 3 2 Protein of unknown function (DUF3808) TPR_4 PF07721.14 CDW58792.1 - 8.3e-05 22.9 1.1 8.8 7.3 0.4 5.3 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 CDW58792.1 - 0.00011 22.3 14.9 12 6.5 0.3 8.8 10 1 0 10 10 9 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDW58792.1 - 0.00014 21.9 6.1 4.4 7.5 0.0 5.7 4 2 2 6 6 6 1 Tetratricopeptide repeat SLT_L PF14718.6 CDW58792.1 - 0.0011 19.1 5.1 0.065 13.4 0.4 3.2 3 1 1 4 4 3 1 Soluble lytic murein transglycosylase L domain NARP1 PF12569.8 CDW58792.1 - 0.0034 16.4 8.5 0.97 8.3 0.2 4.0 1 1 2 4 4 4 2 NMDA receptor-regulated protein 1 PPR PF01535.20 CDW58792.1 - 0.013 15.7 7.9 0.16 12.3 0.0 5.3 6 0 0 6 6 6 0 PPR repeat TPR_11 PF13414.6 CDW58792.1 - 0.02 14.6 18.8 0.057 13.1 4.2 5.7 4 2 2 6 6 6 0 TPR repeat RPN7 PF10602.9 CDW58792.1 - 0.03 14.1 5.0 0.27 10.9 0.2 4.1 3 1 0 3 3 3 0 26S proteasome subunit RPN7 DUF3283 PF11686.8 CDW58792.1 - 0.047 13.5 0.1 0.18 11.7 0.0 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF3283) Fis1_TPR_C PF14853.6 CDW58792.1 - 0.048 13.7 0.2 0.048 13.7 0.2 5.3 6 1 1 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat PPR_2 PF13041.6 CDW58792.1 - 0.079 13.2 0.1 2 8.7 0.0 3.1 3 0 0 3 3 3 0 PPR repeat family TPR_10 PF13374.6 CDW58792.1 - 0.16 11.9 32.4 3 7.8 0.0 8.3 11 0 0 11 11 10 0 Tetratricopeptide repeat DUF1955 PF09205.10 CDW58792.1 - 0.21 11.3 2.0 17 5.2 0.1 3.8 3 1 0 4 4 4 0 Domain of unknown function (DUF1955) DUF2989 PF11207.8 CDW58792.1 - 0.27 10.9 9.3 2.3 7.9 2.1 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF2989) TPR_20 PF14561.6 CDW58792.1 - 0.42 11.0 9.4 3.1 8.2 0.0 4.7 4 1 2 6 6 6 0 Tetratricopeptide repeat EntA_Immun PF08951.10 CDW58792.1 - 5.2 7.5 10.9 0.56 10.6 1.1 3.9 3 1 1 5 5 4 0 Enterocin A Immunity TPR_3 PF07720.12 CDW58792.1 - 5.7 7.0 9.8 0.19 11.8 0.5 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat YitT_membrane PF02588.15 CDW58793.1 - 2.8e-63 213.0 21.2 3.7e-63 212.6 21.2 1.1 1 0 0 1 1 1 1 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF2179 PF10035.9 CDW58793.1 - 1.4e-20 72.8 0.5 1.4e-20 72.8 0.5 2.4 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2179) DUF2892 PF11127.8 CDW58793.1 - 0.9 9.6 6.4 0.19 11.8 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) MazG PF03819.17 CDW58794.1 - 6.4e-18 64.7 0.1 1.1e-17 64.0 0.0 1.4 2 0 0 2 2 2 1 MazG nucleotide pyrophosphohydrolase domain MazG-like PF12643.7 CDW58794.1 - 9.5e-06 25.8 0.0 1.4e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 MazG-like family MobL PF18555.1 CDW58794.1 - 0.0028 17.0 0.6 0.0028 17.0 0.6 1.1 1 0 0 1 1 1 1 MobL relaxases PRA-PH PF01503.17 CDW58794.1 - 0.013 16.0 0.0 0.017 15.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase DivIVA PF05103.13 CDW58794.1 - 0.062 13.4 0.1 0.15 12.2 0.1 1.8 1 1 0 1 1 1 0 DivIVA protein tRNA_NucTran2_2 PF13735.6 CDW58795.1 - 7.8e-41 139.5 0.1 1.2e-40 138.9 0.1 1.3 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative PolyA_pol PF01743.20 CDW58795.1 - 1.1e-37 129.3 0.5 1.9e-37 128.5 0.5 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CDW58795.1 - 4.7e-13 48.7 0.0 1.1e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A VHL_C PF17211.3 CDW58795.1 - 0.053 13.5 0.1 20 5.3 0.0 2.7 2 0 0 2 2 2 0 VHL box domain MarR PF01047.22 CDW58797.1 - 2.7e-12 46.4 0.1 5.8e-12 45.4 0.2 1.5 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 CDW58797.1 - 1.3e-10 41.0 0.2 2.9e-10 39.9 0.1 1.6 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 CDW58797.1 - 3.2e-10 40.3 0.1 6.2e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_34 PF13601.6 CDW58797.1 - 8.1e-05 22.7 0.1 0.00016 21.8 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HxlR PF01638.17 CDW58797.1 - 0.00084 19.1 0.2 0.0052 16.6 0.2 2.0 1 1 0 1 1 1 1 HxlR-like helix-turn-helix HTH_Crp_2 PF13545.6 CDW58797.1 - 0.00093 19.1 0.2 0.0015 18.5 0.2 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain PadR PF03551.14 CDW58797.1 - 0.0012 18.8 0.1 0.0025 17.7 0.1 1.6 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_24 PF13412.6 CDW58797.1 - 0.0016 17.9 0.1 0.003 17.1 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TFIIE_alpha PF02002.17 CDW58797.1 - 0.0071 16.2 0.6 0.01 15.7 0.1 1.5 2 0 0 2 2 2 1 TFIIE alpha subunit SMC_ScpB PF04079.16 CDW58797.1 - 0.014 15.1 0.2 0.028 14.0 0.1 1.5 1 1 1 2 2 2 0 Segregation and condensation complex subunit ScpB TrmB PF01978.19 CDW58797.1 - 0.019 14.8 0.1 0.042 13.7 0.1 1.6 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Fe_dep_repr_C PF02742.15 CDW58797.1 - 0.048 13.7 0.6 0.11 12.5 0.5 1.7 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain PALB2_WD40 PF16756.5 CDW58797.1 - 0.1 11.5 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain Fe_dep_repress PF01325.19 CDW58797.1 - 0.14 12.4 0.3 0.34 11.1 0.1 1.8 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain B-block_TFIIIC PF04182.12 CDW58797.1 - 0.15 12.2 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC DUF1654 PF07867.11 CDW58797.1 - 0.18 11.6 2.6 1.9 8.3 0.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1654) HEAT_2 PF13646.6 CDW58800.1 - 8.4e-24 83.8 0.7 1.9e-10 40.9 0.1 4.0 2 2 2 4 4 4 3 HEAT repeats HEAT_PBS PF03130.16 CDW58800.1 - 2.3e-21 74.2 0.0 0.003 18.1 0.0 6.3 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 CDW58800.1 - 1.9e-05 24.5 1.5 0.72 10.3 0.0 5.0 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 CDW58800.1 - 0.00025 21.5 0.6 3 8.4 0.0 3.9 5 0 0 5 5 5 2 HEAT-like repeat ERAP1_C PF11838.8 CDW58800.1 - 0.0019 17.8 0.5 0.07 12.7 0.0 2.5 2 1 1 3 3 3 1 ERAP1-like C-terminal domain DEAD PF00270.29 CDW58801.1 - 3.8e-51 173.3 0.0 2.7e-50 170.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW58801.1 - 8.6e-28 96.9 0.0 6.1e-27 94.2 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW58801.1 - 6.6e-08 32.7 0.0 6e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CDW58801.1 - 0.00062 19.0 0.0 0.0014 17.9 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase IHABP4_N PF16174.5 CDW58801.1 - 0.19 12.4 8.0 0.48 11.0 8.0 1.6 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal 7tm_2 PF00002.24 CDW58802.1 - 1.3e-51 175.2 12.1 1.8e-51 174.8 12.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF2637 PF10935.8 CDW58802.1 - 0.069 13.1 0.4 0.13 12.2 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2637) HRM PF02793.22 CDW58802.1 - 0.25 11.7 1.1 0.54 10.6 1.1 1.5 1 0 0 1 1 1 0 Hormone receptor domain GSu_C4xC__C2xCH PF09698.10 CDW58802.1 - 2 9.3 4.3 1.6 9.6 2.4 1.8 2 0 0 2 2 2 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) Kringle PF00051.18 CDW58803.1 - 3.7e-15 56.0 18.7 1.3e-07 31.8 2.5 3.9 3 1 1 4 4 4 2 Kringle domain DUF1244 PF06844.11 CDW58803.1 - 0.98 9.6 3.1 1.6 8.9 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1244) CBFD_NFYB_HMF PF00808.23 CDW58804.1 - 6.5e-11 42.4 0.9 1e-10 41.7 0.9 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDW58804.1 - 0.0014 19.0 0.1 0.0021 18.4 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 CDW58804.1 - 0.0087 16.4 0.2 0.019 15.2 0.2 1.6 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CENP-T_C PF15511.6 CDW58804.1 - 0.05 13.7 0.1 0.074 13.2 0.1 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Ribosomal_L36e PF01158.18 CDW58804.1 - 0.1 12.8 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L36e Med3 PF11593.8 CDW58806.1 - 0.018 14.3 1.7 0.024 13.8 1.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SPX PF03105.19 CDW58807.1 - 0.0033 17.4 7.1 0.0033 17.4 7.1 1.9 2 0 0 2 2 2 1 SPX domain TPR_MLP1_2 PF07926.12 CDW58807.1 - 0.57 10.3 9.1 0.18 11.9 5.8 1.8 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4451 PF14616.6 CDW58808.1 - 0.0061 16.8 0.5 0.0061 16.8 0.5 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF4451) MiaE_2 PF13794.6 CDW58808.1 - 0.043 13.5 0.0 0.13 11.9 0.0 1.8 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like zf-BED PF02892.15 CDW58808.1 - 0.18 11.9 8.3 0.1 12.6 4.0 2.6 2 0 0 2 2 2 0 BED zinc finger Tetraspanin PF00335.20 CDW58809.1 - 9.1e-25 87.7 4.4 1.1e-24 87.5 4.4 1.0 1 0 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 CDW58809.1 - 0.052 13.2 6.0 0.072 12.7 4.0 2.0 2 0 0 2 2 2 0 SUR7/PalI family DUF2650 PF10853.8 CDW58809.1 - 2.2 8.0 7.5 0.29 10.9 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2650) Methyltransf_25 PF13649.6 CDW58810.1 - 1.7e-07 31.9 0.1 4.9e-06 27.2 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW58810.1 - 3.8e-07 30.7 0.1 1.2e-05 25.9 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain PrmA PF06325.13 CDW58810.1 - 6.3e-07 29.1 0.1 1e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CDW58810.1 - 6.8e-05 22.7 0.2 0.00049 19.9 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW58810.1 - 7.4e-05 22.6 0.0 0.0002 21.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW58810.1 - 0.0014 19.3 0.0 0.0046 17.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDW58810.1 - 0.0043 16.8 0.0 0.0079 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CDW58810.1 - 0.0091 15.6 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 CDW58810.1 - 0.011 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 CDW58810.1 - 0.018 14.0 0.0 0.032 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) GDE_N_bis PF14742.6 CDW58810.1 - 0.035 13.7 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of (some) glycogen debranching enzymes DOT1 PF08123.13 CDW58810.1 - 0.039 13.5 0.0 0.087 12.3 0.0 1.5 1 0 0 1 1 1 0 Histone methylation protein DOT1 Cons_hypoth95 PF03602.15 CDW58810.1 - 0.04 13.6 0.0 0.1 12.2 0.0 1.7 1 1 0 1 1 1 0 Conserved hypothetical protein 95 MRP-S26 PF14943.6 CDW58811.1 - 3e-44 150.9 11.3 3e-44 150.9 11.3 2.8 3 0 0 3 3 3 1 Mitochondrial ribosome subunit S26 TPR_1 PF00515.28 CDW58811.1 - 2.8e-13 49.0 7.2 1e-07 31.4 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW58811.1 - 4.3e-09 35.8 1.3 0.001 19.0 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW58811.1 - 3.5e-06 27.1 0.0 9.6e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW58811.1 - 0.00011 22.1 3.4 1 9.8 0.1 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW58811.1 - 0.00011 21.8 0.0 0.11 12.1 0.0 3.0 3 0 0 3 3 3 2 TPR repeat TPR_14 PF13428.6 CDW58811.1 - 0.0046 17.7 0.0 27 5.9 0.0 4.0 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDW58811.1 - 0.0061 16.8 1.6 2.5 8.4 0.1 3.1 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW58811.1 - 0.05 14.0 0.0 20 5.9 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L5 PF00281.19 CDW58811.1 - 0.064 13.6 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L5 TPR_16 PF13432.6 CDW58811.1 - 0.11 13.2 0.6 0.28 11.9 0.0 2.1 2 1 0 2 2 1 0 Tetratricopeptide repeat CoA_transf_3 PF02515.17 CDW58811.1 - 0.29 10.2 1.9 0.5 9.4 1.9 1.3 1 0 0 1 1 1 0 CoA-transferase family III AAA_22 PF13401.6 CDW58811.1 - 0.36 11.1 1.6 7.3 6.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain PPDK_N PF01326.19 CDW58811.1 - 0.97 8.6 12.1 0.93 8.7 4.1 2.9 2 1 1 3 3 3 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain MAS20 PF02064.15 CDW58811.1 - 4.5 7.4 15.6 11 6.2 0.1 3.2 3 0 0 3 3 3 0 MAS20 protein import receptor NYD-SP28_assoc PF14775.6 CDW58811.1 - 6.3 7.0 8.7 0.25 11.5 0.4 2.9 3 0 0 3 3 3 0 Sperm tail C-terminal domain FAM76 PF16046.5 CDW58812.1 - 0.085 12.2 1.6 0.12 11.7 1.6 1.2 1 0 0 1 1 1 0 FAM76 protein DUF3665 PF12427.8 CDW58812.1 - 0.19 11.5 2.3 0.5 10.1 2.3 1.7 1 0 0 1 1 1 0 Branched-chain amino acid aminotransferase LLGL PF08366.13 CDW58813.1 - 8e-22 77.6 0.0 2.7e-21 75.8 0.0 1.9 2 0 0 2 2 2 1 LLGL2 Lgl_C PF08596.10 CDW58813.1 - 0.00017 20.4 0.0 0.28 9.8 0.0 3.1 2 1 0 2 2 2 2 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 CDW58813.1 - 0.004 17.9 8.1 0.12 13.3 1.8 4.8 4 1 0 4 4 4 1 WD domain, G-beta repeat Synaptobrevin PF00957.21 CDW58813.1 - 0.021 14.6 0.7 0.039 13.7 0.7 1.4 1 0 0 1 1 1 0 Synaptobrevin 7TM_GPCR_Srw PF10324.9 CDW58815.1 - 8.9e-37 127.1 27.9 1e-36 126.8 27.9 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 CDW58815.1 - 0.011 15.1 18.4 0.017 14.5 18.4 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) PWI PF01480.17 CDW58816.1 - 4.8e-26 90.9 0.2 7.6e-26 90.2 0.2 1.3 1 0 0 1 1 1 1 PWI domain DUF2704 PF10866.8 CDW58816.1 - 0.015 15.2 0.4 0.022 14.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2704) Atrophin-1 PF03154.15 CDW58817.1 - 0.61 8.3 7.4 0.78 8.0 7.4 1.0 1 0 0 1 1 1 0 Atrophin-1 family EB PF01683.18 CDW58818.1 - 0.0098 16.2 14.4 0.0098 16.2 14.4 5.0 3 1 0 3 3 3 2 EB module EGF_MSP1_1 PF12946.7 CDW58818.1 - 0.014 15.4 3.8 0.014 15.4 3.8 5.0 5 1 0 5 5 5 0 MSP1 EGF domain 1 Pkinase PF00069.25 CDW58819.1 - 1.8e-14 53.8 0.0 2.3e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58819.1 - 1.4e-06 27.8 0.0 1.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW58819.1 - 0.0062 16.5 0.1 0.46 10.4 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family DUF1604 PF07713.13 CDW58820.1 - 9.6e-18 63.8 2.0 1.6e-17 63.0 0.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 CDW58820.1 - 0.00043 20.1 0.7 0.0013 18.6 0.1 2.2 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 CDW58820.1 - 0.0088 16.1 0.1 0.0088 16.1 0.1 2.8 3 0 0 3 3 3 1 G-patch domain SNF PF00209.18 CDW58821.1 - 6.8e-66 223.0 35.5 8.2e-66 222.8 35.5 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family VraX PF17412.2 CDW58821.1 - 0.12 12.1 0.8 1.3 8.7 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function Amidinotransf PF02274.17 CDW58822.1 - 1.8e-24 86.5 0.0 8.2e-24 84.3 0.0 1.8 1 1 0 1 1 1 1 Amidinotransferase Fez1 PF06818.15 CDW58823.1 - 0.11 12.9 2.4 0.2 12.1 2.4 1.4 1 1 0 1 1 1 0 Fez1 NUDIX PF00293.28 CDW58824.1 - 1.7e-19 70.1 0.0 2e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Acyl_transf_3 PF01757.22 CDW58825.1 - 9.6e-16 57.8 40.7 9.6e-16 57.8 40.7 2.2 2 0 0 2 2 2 2 Acyltransferase family NIPSNAP PF07978.13 CDW58826.1 - 4.2e-21 75.1 1.2 1.3e-19 70.3 0.7 2.2 2 0 0 2 2 2 2 NIPSNAP ERM PF00769.19 CDW58827.1 - 1.3e-68 231.5 18.6 1.3e-68 231.5 18.6 1.6 2 0 0 2 2 2 1 Ezrin/radixin/moesin family FERM_C PF09380.10 CDW58827.1 - 6.2e-27 93.8 0.6 6.2e-27 93.8 0.6 2.0 3 0 0 3 3 3 1 FERM C-terminal PH-like domain FERM_M PF00373.18 CDW58827.1 - 1.5e-23 83.4 0.2 1.5e-23 83.4 0.2 2.5 3 0 0 3 3 3 1 FERM central domain FERM_N PF09379.10 CDW58827.1 - 1.4e-12 47.3 1.7 7e-12 45.1 0.1 2.9 3 0 0 3 3 3 1 FERM N-terminal domain FlxA PF14282.6 CDW58827.1 - 0.0082 16.1 0.6 0.0082 16.1 0.6 2.9 2 1 0 2 2 2 1 FlxA-like protein ACBP PF00887.19 CDW58827.1 - 0.053 13.7 0.0 0.21 11.8 0.0 2.1 1 0 0 1 1 1 0 Acyl CoA binding protein RhoGEF PF00621.20 CDW58828.1 - 8.5e-35 120.6 0.9 8.5e-35 120.6 0.9 1.8 2 0 0 2 2 2 1 RhoGEF domain PTCB-BRCT PF12738.7 CDW58828.1 - 2.1e-14 53.2 0.8 3.1e-11 43.1 0.2 2.8 2 0 0 2 2 2 2 twin BRCT domain BRCT PF00533.26 CDW58828.1 - 4.3e-13 49.4 0.1 3.1e-06 27.5 0.0 3.0 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CDW58828.1 - 2.1e-06 28.0 0.1 0.08 13.4 0.0 4.0 5 0 0 5 5 5 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CDW58828.1 - 8.9e-06 25.9 1.1 0.1 12.9 0.1 2.5 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain Reprolysin_2 PF13574.6 CDW58829.1 - 7.2e-34 117.4 0.0 1.4e-33 116.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CDW58829.1 - 3e-32 112.4 0.0 6.3e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Disintegrin PF00200.23 CDW58829.1 - 1.7e-14 54.4 12.7 1.7e-14 54.4 12.7 3.6 2 1 0 2 2 2 1 Disintegrin ADAM17_MPD PF16698.5 CDW58829.1 - 1.8e-13 50.6 11.9 1.8e-13 50.6 11.9 3.9 2 1 1 3 3 3 1 Membrane-proximal domain, switch, for ADAM17 Reprolysin_3 PF13582.6 CDW58829.1 - 1.5e-12 48.1 0.0 2.7e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 CDW58829.1 - 5.2e-06 26.7 0.1 9.7e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_4 PF13583.6 CDW58829.1 - 1.8e-05 24.5 0.0 7.8e-05 22.4 0.0 2.1 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 CDW58829.1 - 3.7e-05 23.7 0.2 0.004 17.1 0.0 3.2 3 0 0 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease KH_8 PF17903.1 CDW58830.1 - 9.5e-31 105.7 0.1 2.3e-30 104.5 0.0 1.7 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 CDW58830.1 - 0.00084 19.1 0.0 0.0026 17.5 0.0 1.9 2 1 0 2 2 2 1 KH domain DUF746 PF05344.11 CDW58830.1 - 0.027 14.3 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) KH_4 PF13083.6 CDW58830.1 - 0.092 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 KH domain RNA_pol_Rpb2_1 PF04563.15 CDW58831.1 - 3e-45 154.2 0.3 4e-45 153.8 0.3 1.1 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CDW58831.1 - 1.2e-20 74.0 0.1 2.1e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 CDW58831.1 - 7.9e-14 51.7 0.0 1.7e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 CDW58831.1 - 9e-09 35.8 0.2 3.3e-08 34.0 0.2 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF5384 PF17358.2 CDW58831.1 - 0.032 14.3 0.1 0.066 13.3 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5384) TRP_2 PF08344.11 CDW58832.1 - 2.2e-12 47.0 3.3 4.5e-12 46.0 3.3 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II Ank PF00023.30 CDW58832.1 - 1.9e-07 31.2 0.3 0.00018 21.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CDW58832.1 - 2.5e-07 30.4 2.1 0.00026 21.2 0.0 4.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 CDW58832.1 - 2.2e-05 25.0 0.1 0.0011 19.5 0.0 3.4 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW58832.1 - 0.0027 18.0 0.5 0.015 15.6 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) DUF4711 PF15829.5 CDW58832.1 - 0.011 15.6 0.1 0.021 14.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) Ank_4 PF13637.6 CDW58832.1 - 0.041 14.5 0.1 0.37 11.4 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Peptidase_M24 PF00557.24 CDW58833.1 - 7.8e-39 133.5 0.0 8.9e-39 133.3 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3793 PF12672.7 CDW58833.1 - 0.012 15.7 0.0 0.092 12.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3793) Guanylate_cyc PF00211.20 CDW58834.1 - 7.5e-36 123.5 0.0 1e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Glyco_hydro_18 PF00704.28 CDW58835.1 - 1e-78 265.3 9.4 1.2e-78 265.0 9.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 C2 PF00168.30 CDW58841.1 - 1.7e-21 76.4 0.0 4.8e-21 75.0 0.0 1.9 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 CDW58841.1 - 5.2e-07 30.2 0.2 0.45 11.2 0.0 3.6 3 0 0 3 3 3 3 Putative heavy-metal-binding Motile_Sperm PF00635.26 CDW58841.1 - 0.00074 19.3 0.2 0.0015 18.3 0.2 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Josephin PF02099.17 CDW58842.1 - 1.1e-23 84.2 1.5 1e-21 77.7 1.5 2.6 1 1 0 1 1 1 1 Josephin TEP1_N PF05386.11 CDW58842.1 - 0.056 13.0 0.2 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 TEP1 N-terminal domain DUF1619 PF07773.11 CDW58843.1 - 6.5e-22 78.9 2.8 1.6e-17 64.5 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1619) CUT PF02376.15 CDW58844.1 - 8.2e-05 22.7 0.0 0.00024 21.2 0.0 1.7 2 0 0 2 2 2 1 CUT domain Kelch_4 PF13418.6 CDW58845.1 - 3.7e-22 78.1 6.1 4.2e-09 36.3 0.1 5.4 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CDW58845.1 - 1.8e-17 63.1 4.4 5e-05 23.5 0.2 4.8 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 CDW58845.1 - 1.2e-15 57.1 8.6 4.9e-07 29.8 0.1 5.4 4 1 1 5 5 5 4 Kelch motif Kelch_5 PF13854.6 CDW58845.1 - 4.6e-13 48.8 1.9 3.2e-06 27.0 0.1 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 CDW58845.1 - 2.4e-12 46.3 7.7 0.00048 20.0 0.1 5.1 5 0 0 5 5 5 3 Kelch motif RVT_1 PF00078.27 CDW58845.1 - 7.3e-12 45.3 0.0 1.6e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Kelch_1 PF01344.25 CDW58845.1 - 9.9e-12 44.3 3.6 0.0008 18.9 0.0 5.1 5 0 0 5 5 5 3 Kelch motif F-box-like PF12937.7 CDW58845.1 - 7.3e-08 32.2 0.4 2.3e-07 30.6 0.4 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CDW58845.1 - 1.3e-06 28.2 0.3 3.2e-06 26.9 0.3 1.6 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 CDW58845.1 - 0.0023 17.5 0.3 0.0058 16.2 0.3 1.7 1 0 0 1 1 1 1 F-box Integrase_H2C2 PF17921.1 CDW58845.1 - 0.01 15.9 0.0 0.033 14.3 0.0 1.9 1 0 0 1 1 1 0 Integrase zinc binding domain DEAD PF00270.29 CDW58847.1 - 1.6e-45 155.0 0.0 2.6e-45 154.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW58847.1 - 3.5e-25 88.5 0.0 3.7e-24 85.2 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW58847.1 - 3.7e-07 30.3 0.0 9.8e-07 28.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CDW58847.1 - 0.04 13.6 0.0 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase SecA_DEAD PF07517.14 CDW58847.1 - 0.055 12.7 0.0 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 SecA DEAD-like domain Peptidase_C1 PF00112.23 CDW58848.1 - 1.9e-58 198.1 4.2 4e-58 197.1 4.2 1.5 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 CDW58848.1 - 0.022 13.6 1.3 0.05 12.4 0.2 1.9 2 0 0 2 2 2 0 Peptidase C1-like family Propeptide_C1 PF08127.13 CDW58848.1 - 0.029 14.3 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 Peptidase family C1 propeptide p450 PF00067.22 CDW58849.1 - 3.4e-28 98.6 0.0 4e-28 98.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CDW58850.1 - 2.5e-19 69.4 0.1 3.2e-19 69.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tubulin_C PF03953.17 CDW58851.1 - 1.2e-35 122.4 0.0 2.5e-35 121.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 CDW58851.1 - 4.5e-24 85.7 0.1 6.8e-24 85.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain CooT PF10133.9 CDW58851.1 - 0.043 14.1 0.0 0.094 13.0 0.0 1.6 1 0 0 1 1 1 0 CO dehydrogenase accessory protein CooT Glyoxalase_4 PF13669.6 CDW58853.1 - 4.3e-21 75.2 0.0 5.1e-21 75.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 CDW58853.1 - 4.3e-13 49.6 0.0 4.6e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CDW58853.1 - 4.9e-09 36.5 0.0 6e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CDW58853.1 - 1.8e-05 25.5 0.0 2.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain APG5 PF04106.12 CDW58855.1 - 3.5e-42 144.5 0.4 6.1e-42 143.8 0.4 1.4 1 1 0 1 1 1 1 Autophagy protein Apg5 Trypsin PF00089.26 CDW58856.1 - 3.3e-30 105.6 0.2 2.8e-10 40.4 0.0 4.0 4 0 0 4 4 4 3 Trypsin Macoilin PF09726.9 CDW58856.1 - 1.7 7.1 7.1 2.4 6.6 7.1 1.1 1 0 0 1 1 1 0 Macoilin family Spem1 PF15670.5 CDW58856.1 - 4.2 6.9 7.1 8.2 5.9 7.1 1.4 1 0 0 1 1 1 0 Spermatid maturation protein 1 CAF1C_H4-bd PF12265.8 CDW58858.1 - 4.2e-07 30.1 0.0 4.2e-06 26.9 0.0 2.7 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CDW58858.1 - 0.00025 21.8 16.5 0.69 10.9 0.6 5.2 4 1 0 4 4 4 4 WD domain, G-beta repeat Motile_Sperm PF00635.26 CDW58859.1 - 2.6e-07 30.5 0.5 7.3e-07 29.0 0.5 1.8 1 0 0 1 1 1 1 MSP (Major sperm protein) domain zf-UBP PF02148.19 CDW58860.1 - 2e-21 76.1 3.1 2e-21 76.1 3.1 2.6 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein BRAP2 PF07576.12 CDW58860.1 - 1.9e-15 56.9 0.5 8.8e-15 54.7 0.4 2.2 2 1 0 2 2 2 1 BRCA1-associated protein 2 zf-rbx1 PF12678.7 CDW58860.1 - 1.6e-06 28.3 5.8 4.5e-06 26.8 2.6 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CDW58860.1 - 1.7e-06 28.3 2.8 1.7e-06 28.3 2.8 2.9 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDW58860.1 - 5.1e-06 26.3 10.7 0.0036 17.1 1.6 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDW58860.1 - 9.4e-05 22.2 2.8 9.4e-05 22.2 2.8 3.1 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW58860.1 - 0.00053 19.9 13.7 0.0011 18.9 2.4 3.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CDW58860.1 - 0.00069 19.4 2.5 0.00069 19.4 2.5 2.9 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW58860.1 - 0.0089 15.9 5.2 0.0089 15.9 5.2 3.1 1 1 2 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 CDW58860.1 - 0.014 15.1 0.2 0.014 15.1 0.2 2.9 3 0 0 3 3 2 0 RING-like zinc finger zf-RING_UBOX PF13445.6 CDW58860.1 - 0.15 12.1 0.3 0.15 12.1 0.3 3.2 2 1 0 2 2 2 0 RING-type zinc-finger zf-UBP_var PF17807.1 CDW58860.1 - 0.38 10.5 3.8 0.33 10.7 0.5 2.3 2 0 0 2 2 2 0 Variant UBP zinc finger RecR PF02132.15 CDW58860.1 - 1.4 8.6 6.2 0.83 9.3 1.8 2.3 1 1 1 2 2 2 0 RecR protein zf-C3H2C3 PF17122.5 CDW58860.1 - 2 8.5 12.9 0.25 11.4 5.2 3.1 2 1 1 3 3 2 0 Zinc-finger OrfB_Zn_ribbon PF07282.11 CDW58860.1 - 2.9 7.9 6.7 1.2 9.1 1.5 2.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain DNA_ligase_ZBD PF03119.16 CDW58860.1 - 3.2 7.9 6.1 10 6.3 0.8 2.7 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Zn_ribbon_17 PF17120.5 CDW58860.1 - 3.4 7.4 15.9 4.6 6.9 7.7 3.0 2 1 1 3 3 3 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 CDW58860.1 - 5.5 7.1 11.2 0.091 12.8 3.1 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn-ribbon_8 PF09723.10 CDW58860.1 - 9.2 6.5 11.1 2.8 8.1 1.2 3.0 2 1 1 3 3 3 0 Zinc ribbon domain RRM_1 PF00076.22 CDW58861.1 - 1.6e-07 31.1 0.0 5.2e-07 29.4 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP PF00641.18 CDW58861.1 - 1.5e-05 24.2 4.8 2.1e-05 23.7 4.8 1.2 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-H2C2_2 PF13465.6 CDW58862.1 - 1.4e-10 41.1 26.3 2.2e-06 27.8 1.5 4.6 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 CDW58862.1 - 0.0013 19.1 32.5 0.06 13.8 3.9 4.7 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-Di19 PF05605.12 CDW58862.1 - 0.0018 18.5 12.3 0.051 13.9 6.5 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 CDW58862.1 - 0.012 15.6 1.5 0.012 15.6 1.5 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 CDW58862.1 - 0.33 11.9 32.4 0.13 13.2 3.6 4.9 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW58862.1 - 1.3 9.4 0.0 1.3 9.4 0.0 3.7 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 CDW58862.1 - 2.8 7.9 9.2 18 5.4 0.1 3.6 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DZR PF12773.7 CDW58862.1 - 5.5 7.1 11.1 54 3.9 7.8 3.1 2 1 0 2 2 2 0 Double zinc ribbon zf-C2H2_8 PF15909.5 CDW58862.1 - 7.6 6.9 10.7 9.4 6.6 6.7 2.4 2 0 0 2 2 2 0 C2H2-type zinc ribbon HLH PF00010.26 CDW58863.1 - 1.3e-10 41.0 0.4 2.3e-10 40.2 0.4 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hydrolase_4 PF12146.8 CDW58864.1 - 3.8e-17 62.4 0.0 1.8e-13 50.3 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CDW58864.1 - 5e-11 42.7 0.1 1.1e-10 41.5 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW58864.1 - 1.5e-09 38.8 0.2 3.2e-09 37.7 0.2 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 CDW58864.1 - 4.6e-05 23.4 0.0 8.4e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold LIP PF03583.14 CDW58864.1 - 0.011 15.0 0.0 2.9 7.1 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase DUF829 PF05705.14 CDW58864.1 - 0.015 15.2 0.0 0.34 10.8 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF829) Abhydrolase_2 PF02230.16 CDW58864.1 - 0.017 14.9 0.0 2.3 8.0 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.18 CDW58864.1 - 0.031 13.8 0.1 0.09 12.3 0.1 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family LIDHydrolase PF10230.9 CDW58864.1 - 0.039 13.5 0.0 1.1 8.8 0.0 2.3 1 1 1 2 2 2 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 CDW58864.1 - 0.061 13.2 0.0 0.091 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF3089 PF11288.8 CDW58864.1 - 0.1 12.2 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Polysacc_deac_1 PF01522.21 CDW58864.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide deacetylase Cyt-b5 PF00173.28 CDW58865.1 - 1.2e-24 86.3 0.0 1.4e-24 86.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain MoaC PF01967.21 CDW58866.1 - 2.1e-50 170.3 4.0 3.5e-50 169.6 4.0 1.4 1 0 0 1 1 1 1 MoaC family Mob_synth_C PF06463.13 CDW58866.1 - 2.3e-37 127.8 0.1 4.4e-37 126.9 0.1 1.5 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 CDW58866.1 - 5e-20 72.5 0.0 3.3e-19 69.9 0.0 2.1 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 CDW58866.1 - 0.11 12.8 0.0 0.67 10.2 0.0 2.3 1 1 0 1 1 1 0 4Fe-4S single cluster domain DNA_pol3_beta PF00712.19 CDW58866.1 - 0.13 12.4 0.1 0.29 11.3 0.1 1.5 1 0 0 1 1 1 0 DNA polymerase III beta subunit, N-terminal domain Gly_acyl_tr_N PF06021.11 CDW58867.1 - 3.9e-05 23.8 0.0 0.019 15.1 0.1 2.2 2 0 0 2 2 2 2 Aralkyl acyl-CoA:amino acid N-acyltransferase FAD_binding_1 PF00667.20 CDW58868.1 - 1.4e-66 224.2 0.0 1.9e-66 223.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CDW58868.1 - 5.1e-34 117.5 0.1 7.7e-34 116.9 0.1 1.3 1 0 0 1 1 1 1 Flavodoxin Ammonium_transp PF00909.21 CDW58869.1 - 8.7e-120 400.1 31.3 9.8e-120 399.9 31.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Med25_VWA PF11265.8 CDW58869.1 - 0.2 11.5 0.5 1.5 8.6 0.0 2.1 2 0 0 2 2 2 0 Mediator complex subunit 25 von Willebrand factor type A DNA_pol3_delta2 PF13177.6 CDW58870.1 - 2.2e-59 199.9 0.4 2.2e-59 199.9 0.4 2.2 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Thymidylate_kin PF02223.17 CDW58870.1 - 5.7e-51 172.8 0.0 5.7e-51 172.8 0.0 3.9 4 0 0 4 4 4 1 Thymidylate kinase YbaB_DNA_bd PF02575.16 CDW58870.1 - 1.1e-30 105.7 4.2 1.1e-30 105.7 4.2 3.0 2 0 0 2 2 1 1 YbaB/EbfC DNA-binding family PSP1 PF04468.12 CDW58870.1 - 3.1e-29 101.1 3.2 1.1e-28 99.3 3.2 2.1 1 0 0 1 1 1 1 PSP1 C-terminal conserved region TP_methylase PF00590.20 CDW58870.1 - 5.5e-26 91.8 0.0 1.4e-24 87.3 0.0 2.6 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Toprim_4 PF13662.6 CDW58870.1 - 1.8e-24 86.0 0.3 1e-23 83.6 0.1 2.5 2 0 0 2 2 2 1 Toprim domain RecR PF02132.15 CDW58870.1 - 8.1e-16 57.3 2.2 8.1e-16 57.3 2.2 2.7 2 0 0 2 2 2 1 RecR protein YabA PF06156.13 CDW58870.1 - 6.1e-14 52.5 1.4 6.1e-14 52.5 1.4 4.1 5 0 0 5 5 3 1 Initiation control protein YabA Toprim PF01751.22 CDW58870.1 - 9.5e-09 35.4 0.0 4.7e-08 33.2 0.0 2.3 1 0 0 1 1 1 1 Toprim domain AAA PF00004.29 CDW58870.1 - 2.3e-06 28.0 0.2 0.00029 21.3 0.0 3.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW58870.1 - 0.0033 17.7 1.1 0.83 9.9 0.0 4.3 4 0 0 4 4 4 1 AAA domain AAA_28 PF13521.6 CDW58870.1 - 0.0049 17.1 0.0 0.018 15.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 CDW58870.1 - 0.0064 16.4 0.8 4.2 7.2 0.0 3.5 3 0 0 3 3 3 1 Deoxynucleoside kinase AAA_18 PF13238.6 CDW58870.1 - 0.0092 16.5 0.2 0.44 11.1 0.0 3.7 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CDW58870.1 - 0.019 15.4 0.0 0.51 10.7 0.0 3.3 3 0 0 3 3 3 0 AAA ATPase domain TSC22 PF01166.18 CDW58870.1 - 0.046 14.0 5.6 0.29 11.5 2.4 3.4 2 1 1 3 3 3 0 TSC-22/dip/bun family HAD PF12710.7 CDW58870.1 - 0.13 12.7 0.0 0.46 10.8 0.0 2.0 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RsgA_GTPase PF03193.16 CDW58870.1 - 0.66 9.9 0.0 0.66 9.9 0.0 3.3 4 0 0 4 4 4 0 RsgA GTPase AAA_17 PF13207.6 CDW58870.1 - 5.4 7.4 6.3 10 6.6 0.1 4.2 3 1 0 3 3 3 0 AAA domain DNA_pol3_delta2 PF13177.6 CDW58871.1 - 2.8e-45 154.0 0.1 7.8e-45 152.6 0.1 1.8 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 CDW58871.1 - 2.9e-14 53.6 0.0 2.6e-13 50.5 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_gamma3 PF12169.8 CDW58871.1 - 1.7e-09 37.7 3.2 1.8e-09 37.7 0.4 2.4 3 0 0 3 3 2 1 DNA polymerase III subunits gamma and tau domain III RuvB_N PF05496.12 CDW58871.1 - 4.2e-07 29.9 0.0 2.5e-05 24.1 0.0 2.6 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 CDW58871.1 - 7.1e-06 25.9 0.1 0.00012 21.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW58871.1 - 8.9e-06 26.2 1.1 9.3e-05 22.9 0.0 3.1 3 2 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CDW58871.1 - 3.3e-05 24.2 0.2 0.00061 20.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 CDW58871.1 - 3.5e-05 23.2 0.0 0.26 10.5 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_5 PF07728.14 CDW58871.1 - 6.5e-05 23.0 0.0 0.00045 20.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 CDW58871.1 - 0.00019 21.8 3.8 0.0083 16.5 0.1 4.0 2 2 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 CDW58871.1 - 0.0011 19.3 3.0 0.011 16.1 0.1 3.3 2 1 1 3 3 3 1 AAA C-terminal domain AAA_24 PF13479.6 CDW58871.1 - 0.0011 18.7 0.1 0.015 15.0 0.0 2.7 2 1 1 3 3 3 1 AAA domain T2SSE PF00437.20 CDW58871.1 - 0.0015 17.7 0.4 0.0056 15.8 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_14 PF13173.6 CDW58871.1 - 0.0015 18.5 0.0 0.0064 16.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CDW58871.1 - 0.0033 17.2 0.0 0.4 10.4 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 CDW58871.1 - 0.0034 16.9 0.0 0.35 10.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region TniB PF05621.11 CDW58871.1 - 0.0058 16.1 0.0 1.9 7.8 0.0 2.5 2 0 0 2 2 2 1 Bacterial TniB protein PIF1 PF05970.14 CDW58871.1 - 0.0071 15.5 0.1 0.031 13.5 0.1 2.0 1 1 0 1 1 1 1 PIF1-like helicase Carbpep_Y_N PF05388.11 CDW58871.1 - 0.011 16.2 3.3 0.017 15.6 1.7 2.2 2 0 0 2 2 1 0 Carboxypeptidase Y pro-peptide CSTF1_dimer PF16699.5 CDW58871.1 - 0.014 15.2 0.1 0.9 9.4 0.0 2.6 2 0 0 2 2 2 0 Cleavage stimulation factor subunit 1, dimerisation domain DUF815 PF05673.13 CDW58871.1 - 0.015 14.4 0.2 0.034 13.3 0.0 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 CDW58871.1 - 0.017 14.5 0.0 0.038 13.4 0.0 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI FlxA PF14282.6 CDW58871.1 - 0.019 15.0 6.5 0.065 13.2 6.5 1.9 1 0 0 1 1 1 0 FlxA-like protein AAA_18 PF13238.6 CDW58871.1 - 0.026 15.1 0.0 0.093 13.3 0.0 2.0 2 0 0 2 2 1 0 AAA domain Glyco_tranf_2_5 PF13712.6 CDW58871.1 - 0.031 13.9 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family DUF3573 PF12097.8 CDW58871.1 - 0.036 12.9 0.4 0.052 12.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Phage_int_SAM_6 PF18644.1 CDW58871.1 - 0.047 13.7 0.1 0.095 12.7 0.1 1.5 1 0 0 1 1 1 0 Phage integrase SAM-like domain HALZ PF02183.18 CDW58871.1 - 0.069 13.4 0.6 0.15 12.3 0.6 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper ResIII PF04851.15 CDW58871.1 - 0.071 13.1 7.8 1.1 9.3 0.3 3.1 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.6 CDW58871.1 - 0.077 13.1 0.1 0.79 9.8 0.1 2.6 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF2826 PF11442.8 CDW58871.1 - 0.11 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) betaPIX_CC PF16523.5 CDW58871.1 - 0.14 12.0 2.7 0.26 11.1 0.1 2.7 3 0 0 3 3 2 0 betaPIX coiled coil DNApol3-delta_C PF09115.10 CDW58871.1 - 0.16 12.5 2.2 18 5.9 0.5 2.6 2 0 0 2 2 2 0 DNA polymerase III, delta subunit, C terminal YqgC PF17430.2 CDW58871.1 - 0.17 11.9 1.1 0.27 11.4 0.0 1.9 2 0 0 2 2 1 0 Uncharacterized YqgC-like AAA_28 PF13521.6 CDW58871.1 - 0.18 12.1 1.1 0.45 10.8 0.0 2.3 3 0 0 3 3 1 0 AAA domain DivIC PF04977.15 CDW58871.1 - 0.7 9.7 4.3 1.2 8.9 2.9 2.1 2 0 0 2 2 1 0 Septum formation initiator AAA_23 PF13476.6 CDW58871.1 - 4.5 7.7 9.0 4.2e+02 1.3 8.7 2.7 1 1 0 1 1 1 0 AAA domain TPM_phosphatase PF04536.14 CDW58872.1 - 5.6e-23 81.5 1.2 5.6e-23 81.5 1.2 2.5 3 0 0 3 3 2 1 TPM domain Band_7_1 PF13421.6 CDW58872.1 - 1.4e-18 67.4 0.1 3.5e-18 66.1 0.1 1.6 1 0 0 1 1 1 1 SPFH domain-Band 7 family DZR PF12773.7 CDW58872.1 - 1.8e-05 24.7 18.8 0.00049 20.1 10.6 2.7 1 1 1 2 2 2 2 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 CDW58872.1 - 0.042 13.8 13.0 0.13 12.2 1.5 3.7 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Tox-REase-2 PF15646.6 CDW58872.1 - 0.045 13.9 0.1 9 6.5 0.0 2.7 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 2 zinc_ribbon_15 PF17032.5 CDW58872.1 - 0.1 13.3 17.0 5.4 7.8 0.5 3.5 3 0 0 3 3 3 0 zinc-ribbon family PolC_DP2 PF03833.13 CDW58872.1 - 0.15 9.9 4.3 0.25 9.1 4.3 1.3 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zinc-ribbons_6 PF07191.12 CDW58872.1 - 0.16 12.0 16.9 2.5 8.1 4.2 3.3 2 1 1 3 3 3 0 zinc-ribbons zinc_ribbon_10 PF10058.9 CDW58872.1 - 0.2 11.4 5.6 3.7 7.3 0.2 3.8 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein C1_1 PF00130.22 CDW58872.1 - 0.45 10.4 12.5 0.091 12.7 1.4 3.4 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zinc_ribbon_2 PF13240.6 CDW58872.1 - 0.59 9.9 32.9 1.2 9.0 10.1 4.9 3 3 0 3 3 3 0 zinc-ribbon domain HypA PF01155.19 CDW58872.1 - 0.6 10.2 15.8 0.35 10.9 1.2 3.7 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 CDW58872.1 - 1.2 8.7 28.2 1.8 8.1 0.9 4.6 3 2 2 5 5 5 0 zinc-ribbon domain zf-RanBP PF00641.18 CDW58872.1 - 2.6 7.4 12.3 0.68 9.3 6.9 2.8 2 1 0 2 2 2 0 Zn-finger in Ran binding protein and others DNA_ligase_ZBD PF03119.16 CDW58872.1 - 2.8 8.0 10.4 0.48 10.5 0.4 3.3 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain MqsA_antitoxin PF15731.5 CDW58872.1 - 3.7 7.7 6.9 32 4.6 0.0 4.1 3 1 0 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA Rubredoxin PF00301.20 CDW58872.1 - 6.5 6.9 8.6 2.9 8.0 0.1 3.4 3 1 1 4 4 4 0 Rubredoxin Zn_Tnp_IS1595 PF12760.7 CDW58872.1 - 8.3 6.5 17.2 41 4.3 0.4 4.2 3 1 0 3 3 3 0 Transposase zinc-ribbon domain Peptidase_S11 PF00768.20 CDW58873.1 - 2.1e-73 246.7 0.1 3.2e-73 246.1 0.1 1.2 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 CDW58873.1 - 1.2e-12 47.8 0.1 2.5e-12 46.8 0.1 1.6 1 1 0 1 1 1 1 Beta-lactamase enzyme family PBP5_C PF07943.13 CDW58873.1 - 1.4e-12 47.6 3.4 2.7e-12 46.7 3.4 1.5 1 0 0 1 1 1 1 Penicillin-binding protein 5, C-terminal domain Beta-lactamase PF00144.24 CDW58873.1 - 0.00038 19.8 0.0 0.00063 19.1 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase SCAPER_N PF16501.5 CDW58873.1 - 0.059 13.4 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 S phase cyclin A-associated protein in the endoplasmic reticulum Cass2 PF14526.6 CDW58874.1 - 4.4e-08 33.4 0.0 4.7e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 CDW58874.1 - 1.2e-07 32.1 0.1 1.5e-07 31.8 0.1 1.1 1 0 0 1 1 1 1 GyrI-like small molecule binding domain NdhM PF10664.9 CDW58874.1 - 0.0093 16.2 0.1 0.02 15.1 0.1 1.5 2 0 0 2 2 2 1 Cyanobacterial and plastid NDH-1 subunit M DUF2192 PF09958.9 CDW58874.1 - 0.21 11.1 0.0 0.3 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2192) DUF218 PF02698.17 CDW58875.1 - 2.8e-32 111.5 0.0 3.8e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 DUF218 domain PHO4 PF01384.20 CDW58875.1 - 0.036 13.1 0.7 0.045 12.8 0.7 1.4 1 1 0 1 1 1 0 Phosphate transporter family ABC_tran PF00005.27 CDW58876.1 - 7.4e-32 110.7 0.1 2.2e-31 109.2 0.0 1.9 2 0 0 2 2 2 1 ABC transporter FtsX PF02687.21 CDW58876.1 - 1.9e-09 37.9 0.1 1.9e-09 37.9 0.1 2.8 3 0 0 3 3 3 1 FtsX-like permease family SMC_N PF02463.19 CDW58876.1 - 7.9e-07 28.7 0.6 5.3e-06 26.0 0.6 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDW58876.1 - 3.3e-05 23.8 0.3 0.056 13.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW58876.1 - 0.00056 19.6 0.2 0.0088 15.8 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDW58876.1 - 0.013 15.4 0.5 0.047 13.6 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase MacB_PCD PF12704.7 CDW58876.1 - 0.033 14.6 0.1 0.033 14.6 0.1 2.3 2 0 0 2 2 2 0 MacB-like periplasmic core domain NTPase_1 PF03266.15 CDW58876.1 - 0.037 14.0 0.1 4.7 7.1 0.0 2.5 2 0 0 2 2 2 0 NTPase FtsK_SpoIIIE PF01580.18 CDW58876.1 - 0.062 12.7 0.2 0.31 10.3 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family IgG_binding_B PF01378.17 CDW58876.1 - 0.086 12.9 0.1 11 6.1 0.0 2.9 2 0 0 2 2 2 0 B domain AAA_23 PF13476.6 CDW58876.1 - 0.15 12.6 12.0 0.19 12.2 0.0 3.4 3 0 0 3 3 3 0 AAA domain DHHC PF01529.20 CDW58876.1 - 1.8 8.7 4.2 0.64 10.1 1.1 1.9 2 0 0 2 2 2 0 DHHC palmitoyltransferase Trans_reg_C PF00486.28 CDW58877.1 - 8.5e-23 80.2 0.3 1.8e-22 79.2 0.1 1.7 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal Response_reg PF00072.24 CDW58877.1 - 6.2e-21 74.7 0.2 1.2e-20 73.7 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 CDW58878.1 - 5.5e-28 97.7 0.1 1.2e-27 96.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDW58878.1 - 4.7e-17 61.8 0.3 9.6e-17 60.8 0.3 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDW58878.1 - 6.7e-07 29.6 0.0 1.8e-06 28.2 0.0 1.8 1 1 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 CDW58878.1 - 9.2e-06 25.5 0.1 1.8e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 CDW58878.1 - 1.7e-05 24.6 0.7 3.4e-05 23.7 0.3 1.7 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 CDW58878.1 - 0.03 14.3 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF4229 PF14012.6 CDW58878.1 - 0.12 12.5 6.1 0.23 11.6 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) LpxK PF02606.14 CDW58878.1 - 0.15 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase DUF4097 PF13349.6 CDW58879.1 - 8.8e-27 94.0 18.4 1.1e-26 93.8 18.4 1.1 1 0 0 1 1 1 1 Putative adhesin Toast_rack_N PF17115.5 CDW58879.1 - 0.0024 18.1 4.1 0.14 12.5 1.3 2.9 2 1 1 3 3 3 2 N-terminal domain of toast_rack, DUF2154 Chorein_N PF12624.7 CDW58879.1 - 0.035 14.2 3.3 0.16 12.1 0.3 2.8 1 1 1 2 2 2 0 N-terminal region of Chorein or VPS13 ArAE_1_C PF11728.8 CDW58880.1 - 1.1e-40 139.3 14.0 1.3e-40 139.1 14.0 1.0 1 0 0 1 1 1 1 Putative aromatic acid exporter C-terminal domain FUSC PF04632.12 CDW58880.1 - 0.00018 20.2 0.2 0.00023 19.9 0.2 1.1 1 0 0 1 1 1 1 Fusaric acid resistance protein family ArAE_1 PF06081.11 CDW58880.1 - 0.014 15.5 0.6 0.02 15.0 0.6 1.2 1 0 0 1 1 1 0 Aromatic acid exporter family member 1 ABC1 PF03109.16 CDW58881.1 - 3.2e-32 111.2 0.9 2.1e-31 108.6 0.3 2.5 2 0 0 2 2 2 1 ABC1 family DUF441 PF04284.13 CDW58881.1 - 1e-25 90.4 5.4 1.2e-25 90.1 3.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF441) Pkinase PF00069.25 CDW58881.1 - 0.0043 16.5 1.1 0.0094 15.3 1.1 1.5 1 0 0 1 1 1 1 Protein kinase domain RhaT PF06379.12 CDW58881.1 - 0.022 14.0 0.0 0.36 10.0 0.2 2.1 2 0 0 2 2 2 0 L-rhamnose-proton symport protein (RhaT) COX16 PF14138.6 CDW58881.1 - 1.3 9.6 3.8 11 6.6 0.3 3.0 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 DUF4231 PF14015.6 CDW58881.1 - 6.3 7.3 6.0 39 4.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) DUF5598 PF18127.1 CDW58882.1 - 6e-39 132.4 0.1 8.4e-39 132.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5598) Mito_carr PF00153.27 CDW58883.1 - 3.4e-27 94.2 1.0 8.9e-15 54.4 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Peptidase_C26 PF07722.13 CDW58884.1 - 4.7e-11 42.9 0.0 5.6e-10 39.3 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 CDW58884.1 - 1.7e-07 31.2 0.0 2.9e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 CDW58884.1 - 0.022 14.6 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Amidase PF01425.21 CDW58885.1 - 1e-29 103.9 0.0 1.3e-29 103.5 0.0 1.0 1 0 0 1 1 1 1 Amidase GATase_2 PF00310.21 CDW58886.1 - 6.9e-144 479.6 0.0 2.2e-143 478.0 0.0 1.7 1 1 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CDW58886.1 - 1.7e-115 386.1 0.9 2e-113 379.3 0.4 2.2 2 0 0 2 2 2 2 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CDW58886.1 - 2.8e-110 368.2 0.0 2.6e-109 365.0 0.0 2.0 2 0 0 2 2 2 1 Glutamate synthase central domain GATase_6 PF13522.6 CDW58886.1 - 0.0061 16.8 0.0 0.018 15.2 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain RRM_1 PF00076.22 CDW58887.1 - 2.3e-55 184.3 0.2 3.4e-22 78.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CDW58887.1 - 2.4e-08 33.6 0.0 0.17 11.5 0.0 3.1 1 1 2 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CDW58887.1 - 1.3e-07 31.6 0.1 0.0002 21.4 0.0 2.5 3 0 0 3 3 3 2 RNA binding motif RRM_occluded PF16842.5 CDW58887.1 - 1.6e-07 31.1 0.0 8.4e-06 25.6 0.0 2.6 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_7 PF16367.5 CDW58887.1 - 2.3e-07 30.9 0.3 0.018 15.2 0.0 4.0 3 1 0 3 3 3 2 RNA recognition motif Nup35_RRM_2 PF14605.6 CDW58887.1 - 3.8e-05 23.6 0.3 0.026 14.5 0.1 3.1 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 CDW58887.1 - 6.6e-05 23.2 0.9 0.67 10.2 0.1 3.5 2 2 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Calcipressin PF04847.12 CDW58887.1 - 0.0012 18.6 0.0 0.019 14.7 0.0 2.5 2 1 1 3 3 3 1 Calcipressin RL PF17797.1 CDW58887.1 - 0.0014 18.6 0.3 0.075 13.0 0.0 2.5 2 0 0 2 2 2 1 RL domain Limkain-b1 PF11608.8 CDW58887.1 - 0.004 17.2 0.1 0.67 10.1 0.0 2.6 3 0 0 3 3 3 1 Limkain b1 Nup35_RRM PF05172.13 CDW58887.1 - 0.0052 16.7 0.1 0.11 12.5 0.0 2.8 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 CDW58887.1 - 0.0098 15.7 0.1 0.096 12.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4523) SET_assoc PF11767.8 CDW58887.1 - 0.041 13.5 0.0 14 5.4 0.0 2.6 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated zf-NADH-PPase PF09297.11 CDW58888.1 - 3.3 7.5 8.3 8 6.2 8.3 1.6 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain Vac14_Fig4_bd PF11916.8 CDW58889.1 - 6.5e-46 156.2 7.0 6.5e-46 156.2 7.0 3.0 2 1 1 3 3 3 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 CDW58889.1 - 4.2e-37 126.6 0.5 1.3e-31 109.1 0.0 4.4 4 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CDW58889.1 - 2.9e-06 27.4 1.8 1.1 9.3 0.0 3.8 2 2 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 CDW58889.1 - 0.00078 19.2 1.5 2.5 7.8 0.0 3.6 3 1 0 4 4 4 2 rRNA processing/ribosome biogenesis HEAT_EZ PF13513.6 CDW58889.1 - 0.0035 17.8 2.9 7.2 7.2 0.1 5.0 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.22 CDW58889.1 - 0.0054 16.9 3.3 8 7.0 0.0 5.2 6 0 0 6 6 6 1 HEAT repeat DUF682 PF05081.12 CDW58889.1 - 0.018 14.8 0.4 6.1 6.6 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF682) DUF2053 PF09767.9 CDW58889.1 - 0.09 12.9 0.2 0.35 11.0 0.2 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2053) OSCP PF00213.18 CDW58890.1 - 3e-32 112.1 0.1 3.3e-32 112.0 0.1 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit NIF PF03031.18 CDW58891.1 - 2.9e-49 166.8 0.2 3.7e-49 166.5 0.2 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RSN1_7TM PF02714.15 CDW58892.1 - 2e-25 89.7 20.2 2e-25 89.7 20.2 2.3 2 1 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CDW58892.1 - 0.0063 16.8 0.9 0.45 10.7 0.3 2.2 1 1 1 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter HCV_NS4a PF01006.20 CDW58893.1 - 0.081 12.7 0.2 0.81 9.5 0.0 2.1 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a DIPSY PF11763.8 CDW58894.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Cell-wall adhesin ligand-binding C-terminal Trypsin PF00089.26 CDW58895.1 - 1.8e-12 47.6 0.0 4.8e-09 36.3 0.0 3.1 2 1 1 3 3 3 2 Trypsin MCM_bind PF09739.9 CDW58895.1 - 0.016 13.7 0.8 0.024 13.1 0.8 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF4171 PF13775.6 CDW58895.1 - 0.057 13.9 15.7 0.035 14.6 8.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) ANAPC4_WD40 PF12894.7 CDW58896.1 - 0.00056 20.2 0.1 3.8 7.9 0.0 3.5 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDW58896.1 - 0.18 12.7 3.9 2.1e+02 3.0 0.0 5.6 6 1 0 6 6 6 0 WD domain, G-beta repeat PND PF17949.1 CDW58897.1 - 1.3e-09 38.3 0.4 2.1e-09 37.7 0.4 1.3 1 0 0 1 1 1 1 FANCM pseudonuclease domain HHH_5 PF14520.6 CDW58897.1 - 5.8e-08 33.2 0.0 1e-07 32.4 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 CDW58897.1 - 6.4e-08 32.6 0.0 1.2e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 CDW58897.1 - 0.0094 16.5 0.0 0.059 14.0 0.0 2.1 2 1 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH PF00633.23 CDW58897.1 - 0.025 14.5 0.3 1.1 9.3 0.0 2.7 2 1 0 2 2 2 0 Helix-hairpin-helix motif DHDPS PF00701.22 CDW58897.1 - 0.06 12.0 0.0 0.11 11.1 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Cpn60_TCP1 PF00118.24 CDW58898.1 - 5.7e-145 483.7 4.8 6.5e-145 483.5 4.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family LRR_6 PF13516.6 CDW58899.1 - 3e-17 61.1 19.6 0.00078 19.3 0.4 9.1 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 CDW58899.1 - 6.5e-10 39.1 12.4 0.0067 16.8 1.0 6.2 5 2 2 7 7 7 3 Leucine Rich repeats (2 copies) F-box PF00646.33 CDW58899.1 - 2.3e-08 33.7 3.0 3e-07 30.2 0.2 3.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CDW58899.1 - 5.4e-08 32.6 6.3 5.4e-08 32.6 6.3 3.8 3 1 0 3 3 3 1 F-box-like LRR_1 PF00560.33 CDW58899.1 - 5.3e-06 26.3 28.2 12 6.9 0.1 10.4 10 2 0 10 10 10 2 Leucine Rich Repeat Pkinase PF00069.25 CDW58900.1 - 3.5e-66 223.3 0.0 4.4e-66 223.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58900.1 - 2.8e-32 112.0 0.0 3.8e-32 111.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CDW58900.1 - 1.1e-09 38.8 0.9 2.9e-09 37.5 0.9 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 CDW58900.1 - 1.6e-05 24.4 0.0 3.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 CDW58900.1 - 0.00034 20.3 0.0 0.83 9.2 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CDW58900.1 - 0.0028 16.5 0.0 0.005 15.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDW58900.1 - 0.01 15.2 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW58900.1 - 0.2 11.5 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-CXXC PF02008.20 CDW58901.1 - 1.8e-15 56.7 43.1 3.8e-11 42.8 19.1 2.9 3 0 0 3 3 3 2 CXXC zinc finger domain TetR_C_13 PF16925.5 CDW58902.1 - 0.026 14.4 1.2 0.56 10.2 0.1 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain eIF2_C PF09173.11 CDW58903.1 - 5.1e-37 126.0 0.3 1.2e-36 124.8 0.3 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 CDW58903.1 - 1e-23 83.9 0.1 9e-23 80.8 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CDW58903.1 - 9.3e-11 42.0 1.5 1.5e-10 41.3 0.3 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CDW58903.1 - 0.00032 20.7 0.2 0.013 15.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 CDW58903.1 - 0.0026 17.8 0.0 0.005 16.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 CDW58903.1 - 0.061 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 CDW58903.1 - 0.092 12.8 0.0 0.37 10.8 0.0 2.0 2 0 0 2 2 2 0 Dynamin family Tax PF02959.16 CDW58903.1 - 0.18 11.2 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 HTLV Tax DUF5641 PF18701.1 CDW58904.1 - 9.9e-14 51.3 0.0 2e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) gag-asp_proteas PF13975.6 CDW58905.1 - 0.0043 17.6 0.0 0.0092 16.5 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease BBS1 PF14779.6 CDW58907.1 - 8.7e-40 136.8 0.1 2.2e-39 135.5 0.0 1.7 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 1 PHTB1_N PF14727.6 CDW58907.1 - 2.1e-06 27.3 0.0 2.7e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 PTHB1 N-terminus PQQ_3 PF13570.6 CDW58907.1 - 0.1 13.2 0.0 42 4.8 0.0 4.0 5 0 0 5 5 5 0 PQQ-like domain Cpn60_TCP1 PF00118.24 CDW58908.1 - 1e-18 67.3 0.5 3.1e-15 55.8 0.0 3.0 1 1 2 3 3 3 3 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 CDW58909.1 - 0.00017 20.3 0.3 0.00056 18.7 0.3 1.7 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family EB PF01683.18 CDW58910.1 - 7.1e-06 26.2 5.5 7.1e-06 26.2 5.5 4.6 3 2 0 3 3 3 2 EB module Lustrin_cystein PF14625.6 CDW58910.1 - 0.0047 17.3 7.4 0.0047 17.3 7.4 6.4 4 3 1 5 5 5 2 Lustrin, cysteine-rich repeated domain IMD PF08397.11 CDW58911.1 - 2.7e-38 131.6 1.7 3.7e-38 131.1 1.7 1.2 1 0 0 1 1 1 1 IRSp53/MIM homology domain CHCH PF06747.13 CDW58912.1 - 1.7e-07 31.1 2.4 2.5e-07 30.6 2.4 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 CDW58912.1 - 0.024 14.6 1.7 0.043 13.8 1.7 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.13 CDW58912.1 - 0.026 14.3 0.3 0.035 13.8 0.3 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Synaptobrevin PF00957.21 CDW58913.1 - 6.7e-16 57.9 0.3 1.5e-15 56.7 0.3 1.6 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CDW58913.1 - 3.4e-11 43.0 0.0 7.5e-11 41.9 0.0 1.6 1 1 1 2 2 2 1 Regulated-SNARE-like domain AcylCoA_dehyd_C PF12186.8 CDW58913.1 - 0.058 13.5 0.2 2.5 8.3 0.2 2.2 1 1 1 2 2 2 0 Acyl-CoA dehydrogenase C terminal Cgr1 PF03879.14 CDW58913.1 - 0.061 13.7 0.1 0.091 13.1 0.1 1.2 1 0 0 1 1 1 0 Cgr1 family SAM_1 PF00536.30 CDW58914.1 - 5.3e-33 113.3 0.6 1e-15 57.9 0.3 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW58914.1 - 4.5e-26 90.7 0.1 5.4e-13 48.8 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) DNA_pol_lambd_f PF10391.9 CDW58914.1 - 0.033 14.0 0.0 0.084 12.7 0.0 1.7 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda YAF2_RYBP PF17219.3 CDW58914.1 - 0.17 11.5 0.0 0.46 10.1 0.0 1.7 1 0 0 1 1 1 0 Yaf2/RYBP C-terminal binding motif Cluap1 PF10234.9 CDW58915.1 - 2.4e-80 269.8 11.5 3.1e-80 269.4 11.5 1.1 1 0 0 1 1 1 1 Clusterin-associated protein-1 NPV_P10 PF05531.12 CDW58915.1 - 0.047 14.1 1.0 2.7 8.5 0.2 2.9 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PSD3 PF07626.11 CDW58915.1 - 0.093 13.2 0.2 0.93 10.0 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1587) DUF641 PF04859.12 CDW58915.1 - 0.64 10.4 12.1 1.5 9.2 7.0 2.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF1664 PF07889.12 CDW58915.1 - 4.4 7.4 9.0 3.9 7.5 6.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 CDW58915.1 - 8.2 5.7 11.8 17 4.6 11.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CH PF00307.31 CDW58917.1 - 4.5e-06 26.8 0.0 3e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 Calponin homology (CH) domain Pyr_redox_2 PF07992.14 CDW58917.1 - 7.7e-06 25.3 0.0 1.4e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CDW58917.1 - 8.5e-06 25.2 0.0 1.6e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CDW58917.1 - 3.5e-05 23.2 0.0 6.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CDW58917.1 - 8.5e-05 21.8 0.1 0.00013 21.2 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CDW58917.1 - 0.00018 22.0 0.0 0.00047 20.7 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDW58917.1 - 0.00022 20.1 0.1 0.00037 19.3 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 CDW58917.1 - 0.0021 17.2 0.0 0.0032 16.6 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein CAMSAP_CH PF11971.8 CDW58917.1 - 0.013 15.3 0.0 0.067 13.0 0.0 2.2 1 0 0 1 1 1 0 CAMSAP CH domain NAD_binding_8 PF13450.6 CDW58917.1 - 0.019 15.2 0.0 0.049 13.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 CDW58917.1 - 0.042 14.3 0.0 0.099 13.1 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding DAO PF01266.24 CDW58917.1 - 0.065 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 CDW58917.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 CDW58917.1 - 0.1 11.6 0.5 0.28 10.2 0.0 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 CDW58917.1 - 0.14 11.5 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CDW58917.1 - 0.16 11.8 0.0 0.42 10.5 0.0 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LIM PF00412.22 CDW58917.1 - 8.2 6.7 18.8 0.26 11.5 12.1 2.1 2 0 0 2 2 1 0 LIM domain Arf PF00025.21 CDW58918.1 - 1.4e-40 138.6 0.0 2.3e-40 137.9 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW58918.1 - 1.9e-13 50.7 0.1 3e-13 50.0 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CDW58918.1 - 1.1e-11 44.5 0.0 1.4e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CDW58918.1 - 1.2e-11 44.4 0.5 5.5e-09 35.6 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CDW58918.1 - 7.1e-11 42.0 0.1 8.4e-11 41.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CDW58918.1 - 4.8e-09 35.9 0.0 5.5e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW58918.1 - 4.7e-08 33.1 0.0 6.4e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CDW58918.1 - 0.00075 19.9 0.1 0.87 9.9 0.1 2.2 1 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CDW58918.1 - 0.013 15.8 0.1 0.11 12.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CDW58918.1 - 0.076 12.9 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TUDOR PF00567.24 CDW58919.1 - 6.9e-14 51.9 0.0 1.3e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 Tudor domain Pkinase PF00069.25 CDW58920.1 - 1.3e-15 57.5 0.0 1.6e-15 57.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58920.1 - 8.2e-06 25.3 0.0 1.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW58920.1 - 0.0025 17.8 0.0 0.22 11.4 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family PLDc PF00614.22 CDW58921.1 - 7.7e-18 63.9 5.0 1.1e-08 34.9 0.1 2.9 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 CDW58921.1 - 1e-17 64.3 0.1 3.9e-11 43.0 0.0 2.7 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 CDW58921.1 - 3.5e-09 36.6 1.7 4.5e-08 33.1 1.7 2.5 1 1 0 1 1 1 1 PX domain PH PF00169.29 CDW58921.1 - 0.0013 19.2 0.1 0.013 16.0 0.0 2.5 2 0 0 2 2 2 1 PH domain PhoPQ_related PF10142.9 CDW58923.1 - 0.086 11.5 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein zf-Tim10_DDP PF02953.15 CDW58925.1 - 9.3e-15 54.0 1.3 1.2e-14 53.7 1.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger HOOK PF05622.12 CDW58926.1 - 2.8e-107 359.6 50.2 8.3e-87 292.0 34.0 2.0 1 1 1 2 2 2 2 HOOK protein DprA_WH PF17782.1 CDW58926.1 - 0.051 13.7 1.4 0.43 10.7 0.2 2.8 3 0 0 3 3 3 0 DprA winged helix domain Leu_zip PF15294.6 CDW58926.1 - 0.89 9.0 64.3 1.7 8.1 12.5 3.6 2 2 1 3 3 3 0 Leucine zipper Cir_N PF10197.9 CDW58927.1 - 2.7e-06 27.5 5.7 2.7e-06 27.5 5.7 4.1 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR MMR_HSR1_Xtn PF16897.5 CDW58928.1 - 8.2e-42 141.5 1.3 1.5e-41 140.7 1.3 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 CDW58928.1 - 5.2e-21 74.5 0.0 1.4e-20 73.1 0.0 1.7 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 CDW58928.1 - 3.6e-20 72.2 0.1 1.1e-19 70.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW58928.1 - 3.8e-11 42.7 0.2 3.7e-10 39.5 0.0 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CDW58928.1 - 0.0018 18.4 0.2 0.9 9.6 0.0 2.4 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 CDW58928.1 - 0.002 17.7 0.2 14 5.1 0.1 3.9 2 2 2 4 4 4 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 CDW58928.1 - 0.0079 15.2 0.7 0.082 11.9 0.1 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB PWI PF01480.17 CDW58929.1 - 3.9e-07 30.3 0.2 7e-07 29.5 0.2 1.4 1 0 0 1 1 1 1 PWI domain BBL5 PF07289.11 CDW58929.1 - 0.0014 17.8 0.1 0.0022 17.1 0.1 1.2 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein zf_CCCH_4 PF18345.1 CDW58929.1 - 0.0017 18.4 0.2 0.0042 17.1 0.2 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 CDW58929.1 - 0.0029 17.5 0.3 0.0089 15.9 0.3 1.9 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) CarboxypepD_reg PF13620.6 CDW58930.1 - 3.9e-20 71.9 0.1 1.6e-05 25.1 0.0 5.6 5 0 0 5 5 5 4 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 CDW58930.1 - 2.2e-07 31.1 0.1 6.2 7.1 0.0 5.4 5 0 0 5 5 5 2 SdrD B-like domain CarbopepD_reg_2 PF13715.6 CDW58930.1 - 2.9e-06 27.2 0.1 0.82 9.7 0.0 5.0 5 0 0 5 5 5 2 CarboxypepD_reg-like domain DUF2012 PF09430.10 CDW58930.1 - 0.00091 19.3 0.3 3.3 7.9 0.0 4.5 4 1 0 4 4 4 1 Protein of unknown function (DUF2012) MG4 PF17789.1 CDW58930.1 - 0.011 15.8 0.0 0.5 10.6 0.0 2.8 2 0 0 2 2 2 0 Macroglobulin domain MG4 SpaA PF17802.1 CDW58930.1 - 0.03 14.6 0.0 42 4.6 0.0 3.7 3 0 0 3 3 3 0 Prealbumin-like fold domain DUF3823 PF12866.7 CDW58930.1 - 0.035 14.4 0.0 2.6 8.4 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3823) N-terminal domain Big_1 PF02369.16 CDW58930.1 - 0.092 12.8 8.8 2 8.5 0.0 4.6 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 1) DUF5643 PF18705.1 CDW58930.1 - 0.11 12.5 0.1 9.9 6.2 0.0 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5643) bMG3 PF11974.8 CDW58930.1 - 0.16 12.0 0.0 94 3.1 0.0 3.6 4 0 0 4 4 4 0 Bacterial alpha-2-macroglobulin MG3 domain Integrase_H2C2 PF17921.1 CDW58931.1 - 4.8e-05 23.4 1.4 0.00018 21.5 1.4 1.9 1 1 0 1 1 1 1 Integrase zinc binding domain TUDOR PF00567.24 CDW58935.1 - 5.4e-17 61.9 0.0 2.1e-16 60.1 0.0 2.1 1 0 0 1 1 1 1 Tudor domain BP28CT PF08146.12 CDW58935.1 - 1e-13 51.4 0.8 4e-13 49.5 0.1 2.5 2 0 0 2 2 2 1 BP28CT (NUC211) domain HEAT PF02985.22 CDW58935.1 - 0.00058 19.9 7.6 0.077 13.3 0.0 6.3 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 CDW58935.1 - 0.02 15.3 0.6 1 9.8 0.1 3.7 3 0 0 3 3 3 0 HEAT repeats RTP1_C1 PF10363.9 CDW58935.1 - 0.14 12.3 1.4 8.9 6.5 0.0 3.7 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 PGM_PMM_I PF02878.16 CDW58936.1 - 1e-17 64.2 0.0 1.6e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CDW58936.1 - 0.00094 19.8 0.0 0.002 18.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II C2 PF00168.30 CDW58937.1 - 2.7e-20 72.6 0.0 7.6e-10 39.0 0.0 2.3 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 CDW58937.1 - 0.0013 18.4 0.3 0.95 9.0 0.0 2.5 2 0 0 2 2 2 2 CEP76 C2 domain RF-1 PF00472.20 CDW58938.1 - 1.6e-18 66.7 3.3 2.1e-18 66.4 3.3 1.1 1 0 0 1 1 1 1 RF-1 domain Pkinase_Tyr PF07714.17 CDW58939.1 - 1.8e-07 30.8 0.0 0.0055 16.0 0.0 2.8 2 1 1 3 3 3 2 Protein tyrosine kinase Mus7 PF09462.10 CDW58939.1 - 0.007 15.3 0.1 0.01 14.8 0.1 1.1 1 0 0 1 1 1 1 Mus7/MMS22 family pKID PF02173.17 CDW58939.1 - 0.081 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 pKID domain CDC24_OB3 PF17244.2 CDW58940.1 - 0.01 15.5 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 tRNA_anti-codon PF01336.25 CDW58940.1 - 0.012 15.6 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Dynamin_N PF00350.23 CDW58942.1 - 2.6e-12 47.1 0.0 1.7e-10 41.2 0.0 2.2 1 1 0 1 1 1 1 Dynamin family DUF5600 PF18150.1 CDW58942.1 - 2.9e-11 43.9 0.0 7e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 CDW58942.1 - 1.7e-08 34.3 0.0 4.6e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand MMR_HSR1 PF01926.23 CDW58942.1 - 2.2e-08 34.1 0.0 5.4e-08 32.9 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase EHD_N PF16880.5 CDW58942.1 - 6.6e-07 29.1 0.3 6.6e-07 29.1 0.3 1.9 2 0 0 2 2 2 1 N-terminal EH-domain containing protein Ras PF00071.22 CDW58942.1 - 9.4e-06 25.3 0.1 0.058 13.0 0.0 2.2 2 0 0 2 2 2 2 Ras family RsgA_GTPase PF03193.16 CDW58942.1 - 0.0005 20.0 0.7 0.25 11.2 0.1 2.9 2 1 1 3 3 3 1 RsgA GTPase Roc PF08477.13 CDW58942.1 - 0.0013 18.9 0.1 0.14 12.4 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 CDW58942.1 - 0.0018 17.6 0.0 0.29 10.4 0.0 2.6 3 0 0 3 3 3 1 AIG1 family FeoB_N PF02421.18 CDW58942.1 - 0.0026 17.3 0.0 0.88 9.1 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B EF-hand_1 PF00036.32 CDW58942.1 - 0.0031 17.0 0.4 0.013 15.0 0.6 2.0 2 0 0 2 2 1 1 EF hand Arf PF00025.21 CDW58942.1 - 0.0046 16.4 0.0 0.071 12.6 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family EF-hand_7 PF13499.6 CDW58942.1 - 0.019 15.4 0.0 0.061 13.8 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair GTP_EFTU PF00009.27 CDW58942.1 - 0.025 14.1 0.1 0.4 10.2 0.1 2.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Septin PF00735.18 CDW58942.1 - 0.032 13.5 0.4 0.12 11.6 0.0 2.0 3 0 0 3 3 3 0 Septin TniB PF05621.11 CDW58942.1 - 0.044 13.2 0.0 0.091 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 CDW58942.1 - 0.071 13.5 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 CDW58942.1 - 0.18 11.2 0.1 5.1 6.5 0.0 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit cobW PF02492.19 CDW58942.1 - 0.23 11.0 0.0 20 4.7 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PA28_beta PF02252.18 CDW58943.1 - 5.5e-12 45.6 0.4 1.2e-11 44.4 0.4 1.6 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit Gaa1 PF04114.14 CDW58944.1 - 1e-86 292.0 17.2 1.3e-86 291.6 17.2 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component Mis12 PF05859.12 CDW58944.1 - 1.1e-08 35.2 0.7 2e-08 34.4 0.7 1.4 1 0 0 1 1 1 1 Mis12 protein Rho_GDI PF02115.17 CDW58944.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 RHO protein GDP dissociation inhibitor Mito_carr PF00153.27 CDW58945.1 - 5.2e-64 212.2 2.8 6.5e-22 77.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein THUMP PF02926.17 CDW58946.1 - 1.6e-11 44.5 0.9 2.9e-10 40.4 0.1 2.1 1 1 1 2 2 2 2 THUMP domain Adeno_E3_15_3 PF03307.14 CDW58946.1 - 0.037 14.0 0.4 0.11 12.5 0.1 1.9 2 0 0 2 2 2 0 Adenovirus 15.3kD protein in E3 region Hexokinase_2 PF03727.16 CDW58947.1 - 2e-72 243.5 0.0 2.9e-72 243.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CDW58947.1 - 2.4e-66 223.5 0.0 3.2e-66 223.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Sas6_CC PF18594.1 CDW58947.1 - 0.031 14.0 0.1 0.095 12.5 0.0 1.8 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain Nt_Gln_amidase PF09764.9 CDW58948.1 - 8.6e-47 159.1 0.1 8.5e-39 133.1 0.0 2.0 1 1 1 2 2 2 2 N-terminal glutamine amidase RRP14 PF15459.6 CDW58948.1 - 0.2 12.3 0.0 0.32 11.6 0.0 1.2 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 Mitoc_L55 PF09776.9 CDW58949.1 - 4.2e-31 107.1 0.5 4.6e-31 107.0 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 Tom37_C PF11801.8 CDW58949.1 - 0.0073 16.3 0.0 0.0095 15.9 0.0 1.1 1 0 0 1 1 1 1 Tom37 C-terminal domain T2SSK PF03934.13 CDW58949.1 - 0.035 13.5 0.0 0.04 13.3 0.0 1.0 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein K Oxysterol_BP PF01237.18 CDW58950.1 - 4e-73 246.4 0.2 2e-71 240.8 0.2 2.3 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 CDW58950.1 - 1.2e-12 48.3 0.1 3.1e-12 46.9 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CDW58950.1 - 1.4e-06 28.5 0.1 2.7e-06 27.6 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 CDW58950.1 - 6.4e-06 26.5 1.2 0.00019 21.8 1.2 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 CDW58950.1 - 0.0057 16.9 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Sec3-PIP2_bind PF15277.6 CDW58950.1 - 0.039 14.1 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH PH_13 PF16652.5 CDW58950.1 - 0.064 13.1 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Sun2_CC2 PF18580.1 CDW58950.1 - 0.11 12.8 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 SUN2 coiled coil domain 2 RT_RNaseH_2 PF17919.1 CDW58951.1 - 4.6e-35 119.7 0.0 1.3e-34 118.2 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDW58951.1 - 1.1e-33 115.7 0.1 2.8e-33 114.4 0.1 1.8 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDW58951.1 - 7.9e-20 70.7 0.0 2.1e-19 69.3 0.0 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDW58951.1 - 1.4e-09 38.2 0.1 1.8e-08 34.6 0.0 2.8 3 0 0 3 3 3 1 Integrase core domain gag-asp_proteas PF13975.6 CDW58951.1 - 1.9e-09 38.0 0.8 1.5e-07 31.9 0.0 3.0 3 0 0 3 3 3 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW58951.1 - 1.8e-06 28.5 0.5 1.9e-05 25.2 0.1 2.5 2 0 0 2 2 2 1 Aspartyl protease RVT_1 PF00078.27 CDW58951.1 - 0.00027 20.5 0.1 0.0005 19.7 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease PF09668.10 CDW58951.1 - 0.00037 20.3 0.0 0.00077 19.3 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease zf-CCHC PF00098.23 CDW58951.1 - 0.00049 20.1 2.3 0.00049 20.1 2.3 3.2 3 0 0 3 3 3 1 Zinc knuckle RVP PF00077.20 CDW58951.1 - 0.00072 19.8 0.0 0.0024 18.1 0.0 1.9 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-H2C2 PF09337.10 CDW58951.1 - 0.0025 18.0 0.0 0.0056 16.9 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger TerB_N PF13208.6 CDW58952.1 - 0.059 13.1 0.1 0.09 12.5 0.1 1.2 1 0 0 1 1 1 0 TerB N-terminal domain Glyco_hydro_15 PF00723.21 CDW58953.1 - 2.9e-17 62.6 0.0 2.9e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Flu_NS2 PF00601.19 CDW58953.1 - 0.13 12.6 0.1 0.43 10.9 0.1 1.9 1 0 0 1 1 1 0 Influenza non-structural protein (NS2) HAD_SAK_2 PF18143.1 CDW58954.1 - 0.16 12.2 0.6 0.78 10.1 0.4 2.2 2 1 0 2 2 2 0 HAD domain in Swiss Army Knife RNA repair proteins Peptidase_C28 PF05408.11 CDW58955.1 - 0.047 13.4 1.7 18 5.0 0.0 3.2 3 0 0 3 3 3 0 Foot-and-mouth virus L-proteinase JmjC PF02373.22 CDW58958.1 - 3.6e-20 72.5 0.2 1.1e-19 71.0 0.2 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_11 PF13414.6 CDW58958.1 - 5.2e-09 35.6 2.1 0.023 14.4 0.0 4.7 5 0 0 5 5 5 3 TPR repeat TPR_17 PF13431.6 CDW58958.1 - 1e-08 35.0 0.2 0.061 13.7 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDW58958.1 - 1.1e-08 34.5 6.7 0.0016 18.2 0.1 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW58958.1 - 1.5e-07 31.0 9.3 0.14 12.4 0.1 6.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW58958.1 - 8.3e-06 26.4 0.3 1 10.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDW58958.1 - 2.3e-05 24.6 10.5 0.014 15.7 0.9 4.5 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDW58958.1 - 0.00025 21.6 0.0 3.5 8.7 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDW58958.1 - 0.0095 16.1 2.5 0.066 13.4 0.7 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW58958.1 - 0.011 15.8 2.2 18 5.9 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDW58958.1 - 0.02 15.5 3.5 42 5.1 0.0 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 CDW58958.1 - 0.036 14.6 1.9 4.3 7.9 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat RNA_POL_M_15KD PF02150.16 CDW58959.1 - 1.7e-11 43.7 3.8 1.7e-11 43.7 3.8 1.9 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 CDW58959.1 - 4.8e-05 23.1 11.9 0.0027 17.5 0.8 3.2 2 1 0 2 2 2 2 Transcription factor S-II (TFIIS) DZR PF12773.7 CDW58959.1 - 0.00064 19.7 3.7 0.01 15.8 1.7 2.4 2 0 0 2 2 2 1 Double zinc ribbon Zn_ribbon_recom PF13408.6 CDW58959.1 - 0.0034 17.9 0.5 0.005 17.3 0.5 1.3 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain zinc-ribbons_6 PF07191.12 CDW58959.1 - 0.19 11.7 5.8 0.42 10.6 2.3 2.3 2 0 0 2 2 2 0 zinc-ribbons zf-ACC PF17848.1 CDW58959.1 - 0.24 11.5 0.2 0.24 11.5 0.2 2.8 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-ribbon_3 PF13248.6 CDW58959.1 - 2.4 7.7 10.4 3.2 7.3 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Ribosomal_S27e PF01667.17 CDW58959.1 - 2.7 7.8 8.2 12 5.7 0.5 3.2 3 0 0 3 3 3 0 Ribosomal protein S27 Trehalase PF01204.18 CDW58960.1 - 2.4e-153 511.6 1.0 2.8e-153 511.4 1.0 1.0 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.16 CDW58960.1 - 0.00015 20.6 1.0 0.00033 19.5 0.1 2.0 3 0 0 3 3 3 1 Glycosyl hydrolase family 63 C-terminal domain GDE_C PF06202.14 CDW58960.1 - 0.00042 19.4 1.3 0.0012 17.9 0.1 1.9 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase Bac_rhamnosid6H PF17389.2 CDW58960.1 - 0.0049 16.2 0.2 0.032 13.5 0.0 2.2 2 1 1 3 3 3 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bul1_C PF04426.12 CDW58960.1 - 0.087 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Bul1 C terminus CBF PF03914.17 CDW58961.1 - 5.9e-39 133.8 0.5 5.9e-39 133.8 0.5 3.6 4 0 0 4 4 4 1 CBF/Mak21 family BNIP3 PF06553.12 CDW58962.1 - 7.3e-13 48.6 0.6 1.7e-12 47.4 0.6 1.6 1 1 0 1 1 1 1 BNIP3 CPSF73-100_C PF11718.8 CDW58962.1 - 0.16 11.5 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term EB PF01683.18 CDW58963.1 - 1.9e-05 24.9 30.8 5.4e-05 23.4 12.4 14.4 11 4 4 15 15 15 7 EB module DUF5401 PF17380.2 CDW58963.1 - 0.1 10.7 0.0 0.1 10.7 0.0 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5401) DEAD PF00270.29 CDW58964.1 - 2e-07 30.9 0.1 3.7e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW58964.1 - 3.5e-05 24.1 0.6 0.00017 21.9 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_34 PF13872.6 CDW58965.1 - 1.5e-136 454.2 0.0 2.3e-136 453.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 CDW58965.1 - 3.6e-105 351.5 0.2 8.6e-101 337.2 0.0 2.5 1 1 1 2 2 2 2 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 CDW58965.1 - 6.5e-06 26.2 0.0 1.9e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDW58965.1 - 0.026 14.8 0.0 0.12 12.7 0.0 2.2 1 0 0 1 1 1 0 Helicase conserved C-terminal domain HEAT PF02985.22 CDW58966.1 - 2.3e-36 120.7 25.8 0.0059 16.8 0.0 13.0 13 0 0 13 13 13 9 HEAT repeat HEAT_2 PF13646.6 CDW58966.1 - 3.3e-33 113.9 6.9 7.6e-05 23.0 0.0 8.6 2 2 6 9 9 9 8 HEAT repeats Vac14_Fab1_bd PF12755.7 CDW58966.1 - 1.2e-13 51.4 8.6 0.049 14.2 0.2 7.2 5 2 3 8 8 8 4 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 CDW58966.1 - 3.1e-10 40.3 7.6 0.0043 17.5 0.2 7.6 5 2 2 7 7 7 3 HEAT-like repeat Cnd1 PF12717.7 CDW58966.1 - 1e-06 28.9 10.2 0.053 13.6 0.3 5.1 3 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 CDW58966.1 - 4.5e-06 26.4 3.7 0.39 10.2 0.0 4.3 3 2 1 4 4 4 2 CLASP N terminal TAF6_C PF07571.13 CDW58966.1 - 3.4e-05 24.1 0.2 2 8.8 0.0 4.3 3 1 0 3 3 3 2 TAF6 C-terminal HEAT repeat domain Adaptin_N PF01602.20 CDW58966.1 - 0.00077 18.1 11.9 0.0077 14.8 1.8 3.9 3 2 0 3 3 3 2 Adaptin N terminal region RTP1_C1 PF10363.9 CDW58966.1 - 0.0087 16.2 1.2 18 5.5 0.1 4.0 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 CDW58966.1 - 0.061 14.0 0.1 44 5.2 0.0 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Glyco_transf_92 PF01697.27 CDW58967.1 - 1.6e-30 106.6 0.1 2.1e-30 106.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 CDW58967.1 - 0.016 15.7 0.1 0.034 14.6 0.1 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 FragX_IP PF05994.11 CDW58968.1 - 0 1142.7 8.4 0 1142.7 8.4 1.7 2 0 0 2 2 2 1 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 CDW58968.1 - 2.5e-08 33.5 4.7 5.1e-08 32.5 4.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Tnp_22_trimer PF17489.2 CDW58968.1 - 0.017 15.1 0.1 0.095 12.7 0.0 2.4 2 0 0 2 2 2 0 L1 transposable element trimerization domain Hemocyanin_N PF03722.14 CDW58968.1 - 0.036 14.6 0.5 14 6.2 0.0 2.9 2 0 0 2 2 2 0 Hemocyanin, all-alpha domain TRAM_LAG1_CLN8 PF03798.16 CDW58969.1 - 8.2e-11 42.0 20.5 2.2e-10 40.6 20.5 1.6 1 1 0 1 1 1 1 TLC domain Mito_carr PF00153.27 CDW58971.1 - 5.7e-60 199.3 3.9 2.7e-19 68.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3792 PF12670.7 CDW58971.1 - 0.055 13.6 0.6 0.16 12.1 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) Serine_protease PF18405.1 CDW58971.1 - 0.059 12.5 0.1 7.4 5.6 0.0 2.4 2 1 0 2 2 2 0 Gammaproteobacterial serine protease Pkinase PF00069.25 CDW58972.1 - 4.4e-64 216.4 0.0 9.4e-64 215.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW58972.1 - 5.1e-27 94.8 0.0 8e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 CDW58972.1 - 1.5e-11 44.6 1.4 6.5e-11 42.5 1.4 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.29 CDW58972.1 - 3.5e-06 27.5 0.0 9.4e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 PH domain PTS_IIA PF02255.16 CDW58972.1 - 0.0072 16.4 0.7 0.034 14.2 0.1 2.3 2 0 0 2 2 2 1 PTS system, Lactose/Cellobiose specific IIA subunit Kinase-like PF14531.6 CDW58972.1 - 0.016 14.6 0.0 0.032 13.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like HSP70 PF00012.20 CDW58973.1 - 4.8e-114 381.7 0.0 1.3e-96 324.2 0.0 2.2 1 1 1 2 2 2 2 Hsp70 protein IU_nuc_hydro PF01156.19 CDW58973.1 - 2.6e-91 306.4 0.4 3.3e-90 302.8 0.1 2.4 2 0 0 2 2 2 1 Inosine-uridine preferring nucleoside hydrolase ABC_tran PF00005.27 CDW58973.1 - 9.8e-34 116.8 0.2 1.3e-32 113.2 0.0 2.7 3 0 0 3 3 3 1 ABC transporter MreB_Mbl PF06723.13 CDW58973.1 - 1.5e-12 47.0 0.0 1.8e-11 43.5 0.0 2.5 2 1 0 2 2 2 1 MreB/Mbl protein BPD_transp_1 PF00528.22 CDW58973.1 - 4.1e-11 43.0 4.0 7.5e-11 42.1 4.0 1.4 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component AAA_21 PF13304.6 CDW58973.1 - 3.7e-07 30.3 0.0 0.01 15.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW58973.1 - 4.3e-06 26.3 0.0 1.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain FGGY_C PF02782.16 CDW58973.1 - 0.00018 21.3 0.0 0.0007 19.4 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain RsgA_GTPase PF03193.16 CDW58973.1 - 0.00027 20.9 0.1 0.00086 19.2 0.1 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 CDW58973.1 - 0.0012 19.2 0.0 0.0038 17.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW58973.1 - 0.0017 18.0 0.1 0.004 16.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CDW58973.1 - 0.0019 18.4 0.2 0.011 15.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDW58973.1 - 0.0033 17.8 0.0 0.0093 16.4 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 CDW58973.1 - 0.0062 16.5 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain NTPase_1 PF03266.15 CDW58973.1 - 0.035 14.0 0.4 0.086 12.8 0.4 1.7 1 0 0 1 1 1 0 NTPase DLIC PF05783.11 CDW58973.1 - 0.061 12.2 0.1 0.094 11.5 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) cobW PF02492.19 CDW58973.1 - 0.11 12.1 0.1 0.24 11.0 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CDW58973.1 - 0.12 13.0 0.0 0.3 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDW58973.1 - 0.14 11.8 0.1 0.42 10.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain DUF3269 PF11673.8 CDW58973.1 - 0.17 12.3 0.0 0.68 10.3 0.0 2.0 2 0 0 2 2 1 0 Protein of unknown function (DUF3269) ATPase_2 PF01637.18 CDW58973.1 - 0.18 11.7 0.1 0.41 10.5 0.1 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 CDW58973.1 - 0.19 12.2 0.0 0.39 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF1266 PF06889.11 CDW58974.1 - 6.7e-26 91.4 2.1 9.3e-26 90.9 0.5 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1266) DUF2610 PF11020.8 CDW58974.1 - 0.077 12.9 0.0 0.35 10.8 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2610) DUF2740 PF10872.8 CDW58974.1 - 0.1 12.5 0.1 12 5.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) DUF1266 PF06889.11 CDW58975.1 - 4.5e-41 140.8 7.2 5.3e-41 140.6 7.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1266) NfrA_C PF13283.6 CDW58975.1 - 0.016 14.7 1.1 0.023 14.2 1.1 1.4 1 0 0 1 1 1 0 Bacteriophage N adsorption protein A C-term Sel1 PF08238.12 CDW58976.1 - 2.4e-55 183.7 48.5 3.4e-09 37.1 3.2 8.3 8 1 0 8 8 8 8 Sel1 repeat HTH_16 PF12645.7 CDW58976.1 - 0.11 12.6 0.3 2.5 8.2 0.0 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain TPR_17 PF13431.6 CDW58976.1 - 6.4 7.4 12.9 6.2 7.4 0.1 5.5 4 1 0 5 5 5 0 Tetratricopeptide repeat DUF1451 PF07295.11 CDW58977.1 - 2.8e-53 179.9 0.3 3.2e-53 179.7 0.3 1.0 1 0 0 1 1 1 1 Zinc-ribbon containing domain Apolipoprotein PF01442.18 CDW58977.1 - 0.012 15.5 6.6 0.019 14.8 6.6 1.3 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF4709 PF15821.5 CDW58977.1 - 0.019 15.3 0.9 0.031 14.5 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4709) TniQ PF06527.11 CDW58977.1 - 0.024 15.3 0.3 0.053 14.3 0.3 1.5 1 1 0 1 1 1 0 TniQ VbhA PF18495.1 CDW58977.1 - 0.032 14.1 3.5 0.12 12.2 0.6 2.4 2 0 0 2 2 2 0 Antitoxin VbhA PhnA_Zn_Ribbon PF08274.12 CDW58977.1 - 0.072 13.1 1.7 11 6.1 0.1 2.3 2 0 0 2 2 2 0 PhnA Zinc-Ribbon DUF883 PF05957.13 CDW58977.1 - 0.077 13.6 2.6 0.1 13.2 2.3 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) zinc_ribbon_2 PF13240.6 CDW58977.1 - 0.081 12.7 1.3 1 9.1 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Herpes_UL92 PF03048.14 CDW58977.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 UL92 family Zn-ribbon_8 PF09723.10 CDW58977.1 - 0.17 12.0 2.0 0.47 10.6 2.0 1.8 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_10 PF10058.9 CDW58977.1 - 0.17 11.6 1.9 0.42 10.4 1.9 1.7 1 1 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein TF_Zn_Ribbon PF08271.12 CDW58977.1 - 0.4 10.2 2.4 13 5.4 0.1 2.8 2 0 0 2 2 2 0 TFIIB zinc-binding tRNA-synt_1_2 PF13603.6 CDW58978.1 - 3e-79 264.9 0.0 4.8e-79 264.2 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1 PF00133.22 CDW58978.1 - 5e-70 236.4 11.0 1.6e-25 89.5 0.3 6.1 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDW58978.1 - 1.3e-32 113.1 0.1 4.3e-23 81.7 0.0 4.0 3 1 1 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CDW58978.1 - 3.4e-17 62.8 0.0 6.1e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 CDW58978.1 - 0.00022 20.7 0.0 0.57 9.5 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CDW58978.1 - 0.00022 20.3 0.0 0.24 10.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (K) His_Phos_1 PF00300.22 CDW58979.1 - 1.5e-53 181.4 0.4 3.3e-53 180.3 0.4 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DNA_pol3_delta PF06144.13 CDW58979.1 - 3.5e-47 160.4 0.1 6.5e-47 159.5 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit CTP_transf_like PF01467.26 CDW58979.1 - 3.5e-36 124.5 0.0 7.8e-36 123.4 0.0 1.7 1 0 0 1 1 1 1 Cytidylyltransferase-like DNA_pol3_delt_C PF14840.6 CDW58979.1 - 1e-35 122.8 1.6 3.2e-35 121.2 1.6 1.9 1 0 0 1 1 1 1 Processivity clamp loader gamma complex DNA pol III C-term RsfS PF02410.15 CDW58979.1 - 1.2e-27 96.2 0.1 3.1e-27 94.9 0.1 1.7 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation LptE PF04390.12 CDW58979.1 - 7.3e-13 49.2 0.1 1.7e-12 48.0 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide-assembly HTH_18 PF12833.7 CDW58979.1 - 0.073 13.3 0.1 2.4 8.5 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain SPOUT_MTase PF02590.17 CDW58980.1 - 2.6e-42 144.4 0.0 2.9e-42 144.3 0.0 1.0 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase Transpeptidase PF00905.22 CDW58981.1 - 1.5e-90 303.5 0.0 2.1e-90 303.0 0.0 1.2 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain PBP_dimer PF03717.15 CDW58981.1 - 2.3e-45 155.1 0.7 3.6e-45 154.5 0.7 1.3 1 0 0 1 1 1 1 Penicillin-binding Protein dimerisation domain FTSW_RODA_SPOVE PF01098.19 CDW58982.1 - 7.4e-125 416.7 30.5 8.4e-125 416.5 30.5 1.0 1 0 0 1 1 1 1 Cell cycle protein DPBB_1 PF03330.18 CDW58983.1 - 1.9e-20 73.0 0.0 4.5e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Lytic transglycolase SPOR PF05036.13 CDW58983.1 - 6.3e-17 61.7 2.2 1.6e-16 60.5 2.2 1.7 1 0 0 1 1 1 1 Sporulation related domain Peptidase_S11 PF00768.20 CDW58984.1 - 2e-101 338.5 0.1 2.6e-101 338.1 0.1 1.1 1 0 0 1 1 1 1 D-alanyl-D-alanine carboxypeptidase PBP5_C PF07943.13 CDW58984.1 - 1.1e-24 86.5 0.0 1.9e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Penicillin-binding protein 5, C-terminal domain Beta-lactamase2 PF13354.6 CDW58984.1 - 7.9e-06 25.6 0.0 1.2e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase enzyme family Dr_adhesin PF12393.8 CDW58984.1 - 0.69 10.3 2.9 1.9 8.9 2.9 1.8 1 0 0 1 1 1 0 Dr family adhesin LysR_substrate PF03466.20 CDW58985.1 - 6.2e-17 61.7 0.0 9.3e-17 61.1 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDW58985.1 - 5.5e-11 42.2 0.0 1.1e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family BPL_LplA_LipB PF03099.19 CDW58985.1 - 1.4e-06 28.2 0.0 3.3e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Cro PF09048.10 CDW58985.1 - 0.013 15.5 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 Cro HTH_Mga PF08280.11 CDW58985.1 - 0.016 15.2 0.0 0.063 13.3 0.0 1.9 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain Radical_SAM PF04055.21 CDW58986.1 - 8.3e-15 55.6 0.0 1.2e-14 55.0 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily LIAS_N PF16881.5 CDW58986.1 - 1.2e-07 32.1 0.1 1e-06 29.1 0.1 2.1 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family CN_hydrolase PF00795.22 CDW58987.1 - 1.3e-36 126.2 0.4 1.8e-36 125.9 0.4 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase MttA_Hcf106 PF02416.16 CDW58987.1 - 7.2e-11 41.3 0.4 1.3e-10 40.4 0.4 1.4 1 0 0 1 1 1 1 mttA/Hcf106 family CSD PF00313.22 CDW58988.1 - 2.2e-32 110.7 0.5 2.2e-32 110.7 0.5 1.6 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDW58988.1 - 0.00012 21.7 0.3 0.00023 20.8 0.3 1.5 1 1 0 1 1 1 1 Ribonuclease B OB domain DUF792 PF05632.11 CDW58988.1 - 0.14 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) HMGL-like PF00682.19 CDW58989.1 - 4.6e-96 321.4 0.2 7.2e-96 320.8 0.2 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CDW58989.1 - 2.1e-26 92.4 2.5 2.1e-26 92.4 2.5 2.4 3 0 0 3 3 3 1 LeuA allosteric (dimerisation) domain InvH PF04741.12 CDW58989.1 - 0.14 12.0 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 InvH outer membrane lipoprotein Iso_dh PF00180.20 CDW58990.1 - 4.9e-129 430.4 0.0 5.9e-129 430.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase YlmH_RBD PF17774.1 CDW58990.1 - 0.12 12.6 0.0 4.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Putative RNA-binding domain in YlmH Complex1_LYR PF05347.15 CDW58990.1 - 0.13 12.3 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Complex 1 protein (LYR family) Aconitase PF00330.20 CDW58991.1 - 2.6e-148 494.9 0.0 3.1e-148 494.6 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CDW58992.1 - 3.6e-35 121.2 0.0 5.9e-35 120.5 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain GAF_2 PF13185.6 CDW58992.1 - 2.6e-08 34.3 0.0 4.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CDW58992.1 - 2.7e-06 28.0 0.0 4.3e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 CDW58992.1 - 0.03 14.6 0.0 0.047 14.0 0.0 1.3 1 0 0 1 1 1 0 GAF domain DNA_pol3_delta2 PF13177.6 CDW58993.1 - 2.6e-29 102.1 0.5 1.5e-28 99.7 0.2 2.2 2 0 0 2 2 2 1 DNA polymerase III, delta subunit DNA_pol3_gamma3 PF12169.8 CDW58993.1 - 4.8e-09 36.3 1.6 6.5e-09 35.8 0.5 1.8 2 0 0 2 2 2 1 DNA polymerase III subunits gamma and tau domain III AAA PF00004.29 CDW58993.1 - 7.5e-07 29.6 0.1 2.7e-06 27.8 0.1 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 CDW58993.1 - 0.0001 22.6 0.2 0.00056 20.2 0.1 2.3 1 1 1 2 2 2 1 AAA C-terminal domain DUF4476 PF14771.6 CDW58993.1 - 0.0016 18.7 1.1 0.11 12.8 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4476) DUF3829 PF12889.7 CDW58993.1 - 0.017 14.6 0.4 0.05 13.1 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) AAA_22 PF13401.6 CDW58993.1 - 0.02 15.2 1.0 0.095 13.0 0.0 2.7 3 1 0 3 3 3 0 AAA domain AAA_30 PF13604.6 CDW58993.1 - 0.025 14.3 0.0 0.082 12.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain Glyco_tranf_2_5 PF13712.6 CDW58993.1 - 0.1 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase like family S-AdoMet_synt_C PF02773.16 CDW58994.1 - 1.3e-68 229.2 0.4 2.8e-68 228.2 0.4 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDW58994.1 - 1.4e-51 173.8 0.1 7.4e-51 171.4 0.0 2.2 3 0 0 3 3 3 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CDW58994.1 - 8.5e-39 132.2 0.3 8.5e-39 132.2 0.3 2.3 3 0 0 3 3 3 1 S-adenosylmethionine synthetase, N-terminal domain EPSP_synthase PF00275.20 CDW58995.1 - 3.3e-72 243.5 4.3 6.3e-70 236.0 1.9 2.0 1 1 1 2 2 2 2 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) ADH_zinc_N PF00107.26 CDW58995.1 - 0.0015 18.5 1.2 0.06 13.3 0.1 2.8 2 1 1 3 3 3 1 Zinc-binding dehydrogenase DRTGG PF07085.12 CDW58996.1 - 7.8e-32 109.2 0.1 1.6e-31 108.2 0.1 1.6 1 0 0 1 1 1 1 DRTGG domain CBS PF00571.28 CDW58996.1 - 2.1e-12 47.3 0.2 1.3e-05 25.5 0.0 3.2 3 0 0 3 3 3 2 CBS domain HTH_24 PF13412.6 CDW58996.1 - 2.2e-05 23.9 0.1 0.00041 19.8 0.0 3.0 3 0 0 3 3 2 1 Winged helix-turn-helix DNA-binding GntR PF00392.21 CDW58996.1 - 3.3e-05 23.5 0.1 0.00011 21.8 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family PucR PF07905.11 CDW58996.1 - 0.0003 21.0 0.0 0.0022 18.2 0.0 2.2 1 1 0 1 1 1 1 Purine catabolism regulatory protein-like family HTH_28 PF13518.6 CDW58996.1 - 0.00039 20.5 0.1 0.0012 19.0 0.0 1.8 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_DeoR PF08220.12 CDW58996.1 - 0.00077 19.2 0.1 0.0037 17.0 0.0 2.3 2 0 0 2 2 2 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CDW58996.1 - 0.0011 18.9 0.1 0.0029 17.5 0.1 1.8 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.7 CDW58996.1 - 0.0025 17.7 1.0 0.0074 16.2 0.0 2.3 3 0 0 3 3 2 1 MarR family TrmB PF01978.19 CDW58996.1 - 0.0027 17.5 0.2 0.0079 16.1 0.2 1.9 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Hpr_kinase_N PF02603.16 CDW58996.1 - 0.0034 17.4 0.0 0.01 15.9 0.0 1.8 2 0 0 2 2 2 1 HPr Serine kinase N terminus HTH_Crp_2 PF13545.6 CDW58996.1 - 0.012 15.6 0.3 0.33 11.0 0.0 2.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_36 PF13730.6 CDW58996.1 - 0.013 15.5 0.0 0.052 13.5 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 CDW58996.1 - 0.032 14.0 0.1 0.62 9.9 0.0 2.9 3 0 0 3 3 3 0 Homeodomain-like domain 4HBT PF03061.22 CDW58996.1 - 0.045 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 Thioesterase superfamily HTH_29 PF13551.6 CDW58996.1 - 0.071 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn helix Peptidase_M24 PF00557.24 CDW58997.1 - 6.8e-39 133.7 0.2 1.9e-28 99.6 0.3 2.0 2 0 0 2 2 2 2 Metallopeptidase family M24 DNA_ligase_aden PF01653.18 CDW58998.1 - 4.7e-117 390.6 0.3 9.5e-117 389.6 0.3 1.5 1 0 0 1 1 1 1 NAD-dependent DNA ligase adenylation domain DNA_ligase_OB PF03120.16 CDW58998.1 - 2.9e-34 116.8 1.5 6.6e-34 115.7 1.5 1.6 1 0 0 1 1 1 1 NAD-dependent DNA ligase OB-fold domain HHH_2 PF12826.7 CDW58998.1 - 3.8e-20 71.8 1.1 4.1e-18 65.2 0.3 3.1 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CDW58998.1 - 1.6e-16 60.6 1.0 4.9e-08 33.5 0.0 2.9 3 0 0 3 3 2 2 Helix-hairpin-helix domain BRCT PF00533.26 CDW58998.1 - 1.4e-14 54.3 0.0 3.1e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DNA_ligase_ZBD PF03119.16 CDW58998.1 - 6.5e-09 35.7 2.8 1.3e-08 34.7 2.8 1.5 1 0 0 1 1 1 1 NAD-dependent DNA ligase C4 zinc finger domain PTCB-BRCT PF12738.7 CDW58998.1 - 0.00086 19.2 0.1 0.0026 17.7 0.1 1.9 1 0 0 1 1 1 1 twin BRCT domain RNA_pol_A_CTD PF03118.15 CDW58998.1 - 0.058 13.2 0.0 1.5 8.6 0.0 2.9 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain SpmSyn_N PF17950.1 CDW58998.1 - 0.058 13.6 0.1 0.21 11.8 0.0 2.0 2 0 0 2 2 1 0 S-adenosylmethionine decarboxylase N -terminal RTT107_BRCT_5 PF16770.5 CDW58998.1 - 0.07 13.0 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain SSPI PF14098.6 CDW58998.1 - 0.084 13.0 0.0 0.42 10.8 0.0 2.2 1 0 0 1 1 1 0 Small, acid-soluble spore protein I 5_3_exonuc PF01367.20 CDW58998.1 - 0.1 13.2 0.8 0.54 10.9 0.1 2.8 2 1 1 3 3 2 0 5'-3' exonuclease, C-terminal SAM fold DAGK_cat PF00781.24 CDW58999.1 - 7.7e-29 99.9 0.1 1.3e-28 99.1 0.1 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 CDW58999.1 - 3.4e-05 23.2 0.0 5e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase Fe-ADH_2 PF13685.6 CDW58999.1 - 0.0079 15.9 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase ATP-synt_ab PF00006.25 CDW59000.1 - 4.3e-139 461.2 0.1 3.6e-70 235.9 0.1 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CDW59000.1 - 9.9e-48 161.6 0.3 3.6e-47 159.8 0.0 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CDW59000.1 - 2e-37 127.5 6.1 1.5e-18 67.1 0.8 2.9 2 0 0 2 2 2 2 ATP synthase alpha/beta family, beta-barrel domain OSCP PF00213.18 CDW59000.1 - 1.4e-17 64.4 0.9 3.7e-17 63.0 0.9 1.7 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit ATP-synt PF00231.19 CDW59000.1 - 8.9e-12 45.3 3.8 2.4e-11 43.9 3.8 1.7 1 0 0 1 1 1 1 ATP synthase ATPase PF06745.13 CDW59000.1 - 1.3e-06 27.9 4.0 0.0065 15.8 0.1 2.8 2 0 0 2 2 2 2 KaiC RsgA_GTPase PF03193.16 CDW59000.1 - 9.1e-05 22.4 0.1 0.00035 20.5 0.1 2.0 1 0 0 1 1 1 1 RsgA GTPase ATPase_2 PF01637.18 CDW59000.1 - 0.00029 20.8 0.0 0.21 11.5 0.0 2.8 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 CDW59000.1 - 0.00055 20.4 0.6 0.37 11.2 0.2 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CDW59000.1 - 0.0015 18.2 0.1 0.18 11.4 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 CDW59000.1 - 0.0044 16.6 0.1 0.77 9.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 CDW59000.1 - 0.0052 17.2 0.4 0.17 12.3 0.0 3.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) T3SS_ATPase_C PF18269.1 CDW59000.1 - 0.0063 16.4 0.2 0.086 12.7 0.1 2.8 2 1 0 2 2 2 1 T3SS EscN ATPase C-terminal domain ABC_tran PF00005.27 CDW59000.1 - 0.0094 16.5 0.1 0.038 14.5 0.0 2.0 2 0 0 2 2 1 1 ABC transporter AAA_14 PF13173.6 CDW59000.1 - 0.018 15.1 0.2 14 5.7 0.0 3.5 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 CDW59000.1 - 0.04 14.1 2.2 2.3 8.5 0.1 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 CDW59000.1 - 0.042 14.2 0.1 0.45 10.9 0.0 2.7 3 0 0 3 3 2 0 RNA helicase NACHT PF05729.12 CDW59000.1 - 0.043 13.7 0.1 0.087 12.7 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 CDW59000.1 - 0.088 13.1 0.2 0.27 11.5 0.2 1.8 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 CDW59000.1 - 0.092 12.2 0.0 4.1 6.8 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein NB-ARC PF00931.22 CDW59000.1 - 0.16 11.1 0.4 0.4 9.8 0.4 1.6 1 0 0 1 1 1 0 NB-ARC domain RhoGAP PF00620.27 CDW59001.1 - 1.2e-23 83.6 0.0 2.4e-23 82.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 CDW59001.1 - 1.7e-08 34.2 0.2 2.8e-08 33.6 0.2 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CUB PF00431.20 CDW59002.1 - 1.6e-34 118.5 1.6 3.4e-16 59.6 0.0 2.2 2 0 0 2 2 2 2 CUB domain DUF4618 PF15397.6 CDW59003.1 - 0.00097 18.6 8.6 0.013 14.9 0.6 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4618) Cnn_1N PF07989.11 CDW59003.1 - 0.0074 16.4 8.5 0.0074 16.4 8.5 2.6 1 1 2 3 3 3 1 Centrosomin N-terminal motif 1 DUF3848 PF12959.7 CDW59003.1 - 0.009 16.1 0.8 0.023 14.8 0.8 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3848) zf-C2H2_4 PF13894.6 CDW59003.1 - 0.1 13.5 1.9 0.24 12.3 0.2 2.6 2 1 1 3 3 3 0 C2H2-type zinc finger Malate_synthase PF01274.22 CDW59003.1 - 0.11 10.7 2.4 0.15 10.3 2.4 1.1 1 0 0 1 1 1 0 Malate synthase Herpes_UL6 PF01763.16 CDW59003.1 - 0.54 8.7 7.3 0.7 8.3 7.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Baculo_IE-1 PF05290.11 CDW59003.1 - 0.7 9.8 3.8 0.63 10.0 1.0 2.0 1 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) DivIC PF04977.15 CDW59003.1 - 1.4 8.8 19.8 5.2 6.9 1.4 3.3 1 1 2 3 3 3 0 Septum formation initiator DivIVA PF05103.13 CDW59003.1 - 1.9 8.6 16.0 0.98 9.5 0.4 2.9 1 1 1 2 2 2 0 DivIVA protein Swi5 PF07061.11 CDW59003.1 - 1.9 8.6 9.1 0.24 11.5 0.8 2.5 2 1 0 2 2 2 0 Swi5 CENP-F_leu_zip PF10473.9 CDW59003.1 - 2.3 8.3 25.1 0.8 9.7 22.0 1.8 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YabA PF06156.13 CDW59003.1 - 3 8.6 19.8 0.38 11.4 1.0 3.2 1 1 1 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 CDW59003.1 - 7.9 5.7 13.6 0.12 11.7 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 CDW59003.1 - 9.7 6.0 15.8 19 5.0 10.3 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TMEM132 PF16070.5 CDW59004.1 - 3.8e-23 82.4 0.1 1.8e-14 53.9 0.0 2.2 2 0 0 2 2 2 2 Transmembrane protein family 132 Voltage_CLC PF00654.20 CDW59005.1 - 1.6e-86 290.8 14.3 1.6e-86 290.8 14.3 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CDW59005.1 - 4.3e-15 55.9 0.9 2.2e-06 28.0 0.1 2.6 2 0 0 2 2 2 2 CBS domain EB PF01683.18 CDW59006.1 - 1.4e-08 34.9 32.9 1.7e-06 28.2 3.9 4.6 4 1 1 5 5 5 3 EB module PAP_central PF04928.17 CDW59007.1 - 6.1e-106 352.9 0.0 7.7e-106 352.6 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 CDW59007.1 - 2.1e-17 63.3 0.1 1.4e-12 47.6 0.0 2.3 1 1 1 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 CDW59007.1 - 2.1e-10 40.7 0.0 5.4e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Rrp44_S1 PF17215.3 CDW59007.1 - 0.14 12.2 0.1 0.37 10.8 0.0 1.7 2 0 0 2 2 2 0 S1 domain EF-hand_7 PF13499.6 CDW59008.1 - 6.5e-17 61.7 1.0 1.3e-12 47.9 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW59008.1 - 9.2e-16 56.1 0.7 3.8e-06 26.1 0.2 3.8 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 CDW59008.1 - 1.4e-14 52.7 1.3 1.8e-07 30.5 0.2 3.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 CDW59008.1 - 1.1e-11 43.6 0.2 0.00019 20.8 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 CDW59008.1 - 8.9e-07 28.7 2.8 8e-06 25.6 1.3 2.9 2 1 1 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CDW59008.1 - 8.5e-06 26.1 0.0 5.5e-05 23.5 0.0 2.1 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 CDW59008.1 - 0.0001 22.4 2.3 0.0012 19.0 0.5 2.1 1 1 1 2 2 2 2 Dockerin type I domain EF-hand_4 PF12763.7 CDW59008.1 - 0.0015 18.5 0.1 0.0089 16.0 0.0 2.0 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand UPF0231 PF06062.11 CDW59008.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0231) Nup35_RRM PF05172.13 CDW59010.1 - 1.4e-05 24.9 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Glyco_transf_43 PF03360.16 CDW59011.1 - 3.3e-70 236.1 0.0 3.9e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 43 Tho2 PF11262.8 CDW59012.1 - 1.3e-48 165.7 7.4 2.5e-48 164.8 7.1 1.6 1 1 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 CDW59012.1 - 1.3e-27 95.7 0.4 5.7e-27 93.6 0.4 2.3 1 0 0 1 1 1 1 Transcription- and export-related complex subunit THOC2_N PF16134.5 CDW59012.1 - 2.4e-14 52.9 5.7 3.5e-10 39.2 1.1 3.1 2 1 0 2 2 2 2 THO complex subunit 2 N-terminus STAC2_u1 PF16664.5 CDW59012.1 - 0.25 11.8 0.9 0.43 11.0 0.0 1.8 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 RRM_1 PF00076.22 CDW59013.1 - 1e-20 73.3 0.1 1.3e-20 72.9 0.1 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW59013.1 - 0.00016 21.7 0.0 0.00023 21.2 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif FYVE PF01363.21 CDW59014.1 - 4.7e-20 71.5 7.6 9e-20 70.6 7.6 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 CDW59014.1 - 1.2e-07 32.2 0.1 5.8e-07 30.0 0.0 1.9 2 0 0 2 2 2 1 PH domain Ribosomal_60s PF00428.19 CDW59014.1 - 0.047 14.3 1.0 0.092 13.3 1.0 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF1835 PF08874.10 CDW59014.1 - 0.059 13.6 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1835) Adeno_PIX PF03955.14 CDW59014.1 - 0.11 12.7 0.1 0.18 12.0 0.1 1.3 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) FYVE_2 PF02318.16 CDW59014.1 - 0.14 12.4 6.8 0.32 11.2 6.8 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger zf-C2H2_12 PF18658.1 CDW59014.1 - 1.4 8.6 5.3 10 5.8 0.1 2.6 1 1 0 2 2 2 0 Zinc-finger C2H2-type zf-UBP PF02148.19 CDW59014.1 - 2.8 8.3 8.6 31 5.0 9.0 2.1 1 1 1 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein zf-piccolo PF05715.13 CDW59014.1 - 6.2 7.1 11.1 3.9 7.7 8.7 2.0 2 0 0 2 2 2 0 Piccolo Zn-finger zf-B_box PF00643.24 CDW59014.1 - 9.8 6.4 10.9 2.9 8.1 6.6 2.3 1 1 1 2 2 2 0 B-box zinc finger BORA_N PF15280.6 CDW59015.1 - 1.2e-27 97.1 6.5 1.3e-26 93.7 6.5 2.3 1 1 0 1 1 1 1 Protein aurora borealis N-terminus HMw1_D2 PF18254.1 CDW59015.1 - 0.06 13.7 0.2 0.17 12.2 0.0 1.8 2 0 0 2 2 2 0 HMW1 domain 2 CTP_synth_N PF06418.14 CDW59016.1 - 6.7e-83 278.0 0.1 1.1e-82 277.3 0.1 1.3 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CDW59016.1 - 1.1e-18 67.7 0.0 1.7e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CbiA PF01656.23 CDW59016.1 - 0.0009 19.3 0.0 0.0024 17.9 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CDW59016.1 - 0.026 13.7 0.3 0.05 12.8 0.3 1.4 1 0 0 1 1 1 0 Anion-transporting ATPase ParA PF10609.9 CDW59016.1 - 0.063 12.7 0.5 0.14 11.5 0.5 1.6 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase MeaB PF03308.16 CDW59016.1 - 0.084 11.8 0.2 0.2 10.6 0.2 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 CDW59016.1 - 0.098 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain BppL_N PF18338.1 CDW59016.1 - 0.2 11.5 0.2 0.41 10.5 0.2 1.5 1 0 0 1 1 1 0 Lower baseplate protein N-terminal domain Nse4_C PF08743.10 CDW59017.1 - 1.5e-16 60.4 0.1 4.9e-16 58.8 0.1 1.9 1 0 0 1 1 1 1 Nse4 C-terminal VHL_C PF17211.3 CDW59017.1 - 0.075 13.1 0.9 0.32 11.1 0.5 2.1 2 0 0 2 2 2 0 VHL box domain Pou PF00157.17 CDW59018.1 - 8.3e-30 102.6 0.1 1.5e-29 101.8 0.1 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 CDW59018.1 - 7.4e-17 60.9 0.8 1.9e-16 59.6 0.8 1.7 1 0 0 1 1 1 1 Homeodomain Septin PF00735.18 CDW59019.1 - 3.7e-92 308.6 0.0 3.7e-92 308.6 0.0 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CDW59019.1 - 2.1e-05 24.6 0.0 8e-05 22.7 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CDW59019.1 - 0.00025 20.7 0.4 0.59 9.6 0.0 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CDW59019.1 - 0.0012 19.2 0.3 0.0034 17.8 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CDW59019.1 - 0.0017 18.3 0.9 0.11 12.4 0.0 2.8 3 0 0 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 CDW59019.1 - 0.0021 18.3 0.4 0.013 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain Ras PF00071.22 CDW59019.1 - 0.0023 17.6 0.0 0.0071 16.0 0.0 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 CDW59019.1 - 0.0037 17.5 0.0 0.0085 16.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 CDW59019.1 - 0.018 14.6 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Microtub_bd PF16796.5 CDW59019.1 - 0.028 14.4 0.0 0.43 10.5 0.0 2.4 2 0 0 2 2 2 0 Microtubule binding Dynamin_N PF00350.23 CDW59019.1 - 0.081 13.0 1.2 0.27 11.3 0.0 2.1 2 0 0 2 2 2 0 Dynamin family ABC_tran PF00005.27 CDW59019.1 - 0.089 13.3 3.8 0.21 12.1 0.0 2.5 2 1 0 2 2 2 0 ABC transporter DUF87 PF01935.17 CDW59019.1 - 0.096 12.8 5.1 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 CDW59019.1 - 0.16 12.4 0.0 0.45 10.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.6 CDW59019.1 - 0.27 11.7 10.6 2.9 8.4 0.4 2.6 2 1 0 2 2 2 0 AAA domain DUF2461 PF09365.10 CDW59019.1 - 0.37 10.7 4.0 0.53 10.2 0.8 2.3 2 1 0 2 2 2 0 Conserved hypothetical protein (DUF2461) Exonuc_VII_L PF02601.15 CDW59019.1 - 2.7 7.5 10.5 4.1 6.9 10.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 CDW59019.1 - 3.1 7.1 5.9 5.2 6.3 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Motile_Sperm PF00635.26 CDW59020.1 - 1.9e-10 40.6 0.0 2.2e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Sec6 PF06046.13 CDW59021.1 - 3e-85 286.7 1.9 3e-85 286.7 1.9 2.5 2 1 0 2 2 2 1 Exocyst complex component Sec6 THOC7 PF05615.13 CDW59021.1 - 0.17 12.2 8.9 0.74 10.1 4.5 2.8 2 0 0 2 2 2 0 Tho complex subunit 7 P-mevalo_kinase PF04275.14 CDW59022.1 - 2.5e-38 130.5 0.1 3.8e-38 130.0 0.1 1.3 1 0 0 1 1 1 1 Phosphomevalonate kinase DUF5086 PF16985.5 CDW59022.1 - 0.11 12.4 1.3 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5086) Ala_racemase_N PF01168.20 CDW59023.1 - 3.1e-22 79.3 0.0 4e-22 78.9 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Tyrosinase PF00264.20 CDW59024.1 - 1.4e-22 81.1 0.6 1.3e-20 74.6 0.6 2.8 1 1 0 1 1 1 1 Common central domain of tyrosinase DUF220 PF02713.14 CDW59024.1 - 0.23 11.6 2.9 0.35 11.0 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF220 Nop52 PF05997.12 CDW59025.1 - 2.5e-55 187.6 3.8 3.5e-55 187.1 3.8 1.2 1 0 0 1 1 1 1 Nucleolar protein,Nop52 2CSK_N PF08521.10 CDW59025.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Two-component sensor kinase N-terminal Ldl_recept_a PF00057.18 CDW59026.1 - 8.3e-269 867.5 512.1 5.3e-12 45.7 10.6 34.7 32 2 2 34 34 34 31 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 CDW59026.1 - 1.4e-128 419.2 93.9 3.9e-07 30.4 0.1 33.1 35 0 0 35 35 35 23 Low-density lipoprotein receptor repeat class B FXa_inhibition PF14670.6 CDW59026.1 - 1.2e-33 115.0 148.9 1.5e-08 34.8 5.6 29.7 24 3 6 30 30 30 11 Coagulation Factor Xa inhibitory site SGL PF08450.12 CDW59026.1 - 3.3e-17 62.9 21.5 0.011 15.3 0.2 12.6 10 4 1 11 11 11 7 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 CDW59026.1 - 9.5e-14 51.0 13.7 2.5e-10 40.1 2.1 22.6 21 1 0 21 21 21 9 Complement Clr-like EGF-like EGF_CA PF07645.15 CDW59026.1 - 5e-08 33.0 22.9 1.3e-06 28.5 6.4 37.3 31 9 12 43 43 43 3 Calcium-binding EGF domain EGF PF00008.27 CDW59026.1 - 6.8e-05 23.1 18.7 0.00043 20.5 5.8 38.1 41 2 1 42 42 42 17 EGF-like domain hEGF PF12661.7 CDW59026.1 - 0.0033 18.0 4.0 0.0033 18.0 4.0 34.9 37 1 0 37 37 37 8 Human growth factor-like EGF polyprenyl_synt PF00348.17 CDW59027.1 - 4.3e-18 65.3 0.0 2e-10 40.2 0.0 3.1 1 1 2 3 3 3 2 Polyprenyl synthetase ABC_tran PF00005.27 CDW59027.1 - 2.6e-07 31.2 0.0 5.4e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW59027.1 - 0.0072 16.2 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system NB-ARC PF00931.22 CDW59027.1 - 0.052 12.7 0.0 0.084 12.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 CDW59027.1 - 0.067 13.1 0.2 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_23 PF13476.6 CDW59027.1 - 0.15 12.5 0.4 0.4 11.2 0.1 1.8 2 0 0 2 2 2 0 AAA domain BAR PF03114.18 CDW59028.1 - 7.8e-13 48.6 7.1 9.3e-13 48.4 7.1 1.0 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 CDW59028.1 - 1.6e-05 24.7 5.4 2.3e-05 24.2 5.4 1.3 1 0 0 1 1 1 1 BAR domain of APPL family BAR_2 PF10455.9 CDW59028.1 - 0.00069 18.8 4.6 0.00081 18.6 4.6 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking ABC_tran PF00005.27 CDW59029.1 - 1.2e-33 116.5 0.0 6.3e-21 75.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CDW59029.1 - 1.6e-23 82.6 1.1 2.7e-23 81.8 1.1 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW59029.1 - 3.5e-12 46.8 2.6 0.00011 22.2 0.1 3.5 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW59029.1 - 6.9e-10 38.7 0.1 1.8e-05 24.3 0.0 3.2 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDW59029.1 - 0.00072 19.4 2.7 0.0016 18.2 0.0 2.4 2 1 0 3 3 3 1 AAA ATPase domain AAA_23 PF13476.6 CDW59029.1 - 0.00093 19.8 0.3 0.016 15.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDW59029.1 - 0.0042 17.0 0.0 0.013 15.4 0.0 1.9 1 0 0 1 1 1 1 NACHT domain SbcCD_C PF13558.6 CDW59029.1 - 0.014 15.6 1.1 2.3 8.5 0.2 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DLIC PF05783.11 CDW59029.1 - 0.016 14.0 0.3 0.4 9.5 0.0 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) TsaE PF02367.17 CDW59029.1 - 0.019 15.0 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 CDW59029.1 - 0.025 14.3 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CDW59029.1 - 0.027 14.2 0.0 0.063 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 CDW59029.1 - 0.03 13.8 0.0 0.06 12.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.20 CDW59029.1 - 0.064 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_22 PF13401.6 CDW59029.1 - 0.066 13.5 0.5 0.25 11.6 0.0 2.3 3 1 0 3 3 3 0 AAA domain AAA_18 PF13238.6 CDW59029.1 - 0.081 13.5 0.3 0.68 10.5 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 CDW59029.1 - 0.15 12.1 0.1 0.76 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Dynamin_N PF00350.23 CDW59030.1 - 3e-35 121.8 0.0 1.1e-34 120.0 0.0 2.0 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CDW59030.1 - 0.00015 21.1 5.6 0.00017 20.9 0.1 3.1 3 1 0 4 4 4 1 Dynamin central region MMR_HSR1 PF01926.23 CDW59030.1 - 0.001 19.2 0.0 0.0054 16.8 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF1593 PF07632.11 CDW59030.1 - 0.018 14.5 0.0 0.064 12.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) AAA_16 PF13191.6 CDW59030.1 - 0.034 14.5 0.0 0.29 11.5 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 CDW59030.1 - 0.13 11.8 0.1 17 5.0 0.0 2.9 3 0 0 3 3 3 0 Ras family Glyco_hydro_46 PF01374.18 CDW59030.1 - 0.13 11.8 0.0 0.35 10.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 AAA_15 PF13175.6 CDW59030.1 - 0.36 10.5 4.1 1.1 8.9 0.0 2.8 2 1 1 3 3 3 0 AAA ATPase domain 23S_rRNA_IVP PF05635.11 CDW59030.1 - 0.46 10.8 3.3 1.1 9.6 0.2 2.8 3 0 0 3 3 3 0 23S rRNA-intervening sequence protein NYD-SP28_assoc PF14775.6 CDW59030.1 - 0.93 9.6 5.9 0.62 10.2 2.2 2.8 2 0 0 2 2 2 0 Sperm tail C-terminal domain Hus1 PF04005.12 CDW59031.1 - 2.7e-45 154.8 0.9 3e-45 154.6 0.9 1.0 1 0 0 1 1 1 1 Hus1-like protein Pterin_bind PF00809.22 CDW59031.1 - 0.0035 17.1 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 Pterin binding enzyme PTRF_SDPR PF15237.6 CDW59032.1 - 3.6e-06 26.8 9.9 3.6e-06 26.8 9.9 1.5 2 0 0 2 2 2 1 PTRF/SDPR family CorA PF01544.18 CDW59032.1 - 0.0032 16.9 5.3 0.0055 16.0 5.3 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF1192 PF06698.11 CDW59032.1 - 0.011 15.8 1.7 0.027 14.5 1.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Borrelia_REV PF03978.13 CDW59032.1 - 0.014 15.4 7.9 4.9 7.1 0.1 3.3 1 1 2 3 3 3 0 Borrelia burgdorferi REV protein DUF3834 PF12916.7 CDW59032.1 - 0.019 14.3 1.0 0.029 13.6 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) zf-C4H2 PF10146.9 CDW59032.1 - 0.03 14.7 10.2 0.047 14.0 10.2 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein DUF1729 PF08354.10 CDW59032.1 - 0.072 12.0 2.5 0.097 11.5 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) FUSC PF04632.12 CDW59032.1 - 0.1 11.1 0.3 0.13 10.7 0.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF948 PF06103.11 CDW59032.1 - 0.14 12.5 7.8 0.12 12.6 1.1 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Zincin_2 PF10103.9 CDW59032.1 - 0.22 10.8 2.5 0.5 9.6 0.0 2.0 1 1 1 2 2 2 0 Zincin-like metallopeptidase DHHA1 PF02272.19 CDW59032.1 - 0.23 11.9 1.9 0.41 11.1 1.4 1.7 1 1 0 1 1 1 0 DHHA1 domain Tho2 PF11262.8 CDW59032.1 - 0.42 9.8 5.1 0.18 11.0 1.3 2.1 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Vps39_1 PF10366.9 CDW59032.1 - 1.3 9.3 4.6 3.4 8.0 0.6 2.3 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 1 ING PF12998.7 CDW59032.1 - 1.4 9.5 10.4 5.9 7.5 7.4 2.5 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding TraH PF06122.11 CDW59032.1 - 1.6 7.9 7.3 4.9 6.3 0.6 2.1 1 1 1 2 2 2 0 Conjugative relaxosome accessory transposon protein RasGAP_C PF03836.15 CDW59032.1 - 1.9 8.6 8.9 15 5.7 8.9 2.2 1 1 0 1 1 1 0 RasGAP C-terminus YkyA PF10368.9 CDW59032.1 - 3.2 7.4 16.4 4 7.1 5.5 3.0 2 1 1 3 3 3 0 Putative cell-wall binding lipoprotein YabA PF06156.13 CDW59032.1 - 5.8 7.6 11.3 25 5.6 9.0 2.3 1 1 1 2 2 2 0 Initiation control protein YabA V_ATPase_I PF01496.19 CDW59032.1 - 6.2 4.6 8.5 8.2 4.2 8.5 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family F_actin_bind PF08919.10 CDW59032.1 - 7.2 6.8 10.5 8 6.6 5.1 3.1 2 1 1 3 3 2 0 F-actin binding MRPL52 PF18699.1 CDW59032.1 - 9.5 6.5 11.8 0.3 11.3 3.8 2.4 2 1 0 3 3 3 0 Mitoribosomal protein mL52 Spec3 PF15795.5 CDW59033.1 - 2.9e-26 91.8 10.6 4.3e-26 91.3 10.6 1.3 1 0 0 1 1 1 1 Ectodermal ciliogenesis protein SPRY PF00622.28 CDW59034.1 - 2.1e-20 73.0 0.0 4.2e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.21 CDW59034.1 - 3.7e-06 27.2 0.0 8.2e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain zf-C3HC4_4 PF15227.6 CDW59034.1 - 3.7e-06 27.0 4.5 3.7e-06 27.0 4.5 4.5 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CDW59034.1 - 8.6e-06 25.7 3.9 8.6e-06 25.7 3.9 3.5 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW59034.1 - 8.4e-05 22.3 1.9 8.4e-05 22.3 1.9 4.5 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW59034.1 - 0.00042 20.1 2.5 0.00042 20.1 2.5 4.3 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) DUF5405 PF17399.2 CDW59034.1 - 0.0054 17.0 1.3 1.7 8.9 0.2 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5405) zf-B_box PF00643.24 CDW59034.1 - 0.0062 16.7 6.8 0.0062 16.7 6.8 4.4 4 1 0 4 4 4 2 B-box zinc finger DUF2353 PF09789.9 CDW59034.1 - 0.054 12.8 2.0 0.078 12.3 2.0 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Baculo_PEP_C PF04513.12 CDW59034.1 - 0.1 12.6 3.3 0.18 11.8 3.3 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus zinc_ribbon_4 PF13717.6 CDW59034.1 - 4.9 7.2 10.1 4.5 7.3 0.2 4.0 4 0 0 4 4 3 0 zinc-ribbon domain Aa_trans PF01490.18 CDW59035.1 - 2.1e-65 221.0 24.2 2.5e-65 220.8 24.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF11 PF01345.18 CDW59035.1 - 0.058 13.7 0.1 0.19 12.1 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF11 AtpR PF12966.7 CDW59035.1 - 0.068 13.6 0.4 0.068 13.6 0.4 2.5 3 0 0 3 3 3 0 N-ATPase, AtpR subunit CRPA PF05745.11 CDW59035.1 - 4.4 7.3 6.3 0.66 10.0 1.1 2.4 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Trypsin PF00089.26 CDW59036.1 - 5.1e-09 36.3 0.0 2.6e-08 34.0 0.0 2.1 1 1 0 1 1 1 1 Trypsin DUF2845 PF11006.8 CDW59036.1 - 0.076 13.1 0.3 6.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2845) Motile_Sperm PF00635.26 CDW59038.1 - 3.6e-15 55.8 0.0 4.2e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Acatn PF13000.7 CDW59039.1 - 1.7e-87 294.2 9.3 5.3e-73 246.4 5.0 2.0 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 7tm_3 PF00003.22 CDW59041.1 - 1.6e-55 188.4 24.8 1.6e-55 188.4 24.8 2.2 2 1 1 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 CDW59041.1 - 1.2e-37 129.9 0.3 1.6e-37 129.4 0.3 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region SAD_SRA PF02182.17 CDW59041.1 - 0.075 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 SAD/SRA domain DUF2976 PF11190.8 CDW59041.1 - 9.6 6.1 9.0 0.84 9.5 0.6 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF2976) ATP-synt_ab PF00006.25 CDW59042.1 - 3.3e-53 180.5 0.0 5e-53 179.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CDW59042.1 - 1.5e-49 167.5 3.0 2.1e-49 167.0 3.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain DUF4142 PF13628.6 CDW59042.1 - 2e-05 24.8 1.6 3.2e-05 24.2 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4142) DUF3762 PF12591.8 CDW59042.1 - 0.025 14.8 0.0 0.069 13.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3762) Bromodomain PF00439.25 CDW59043.1 - 1.3e-81 268.7 19.6 7.4e-21 74.0 1.1 6.4 5 1 1 6 6 6 6 Bromodomain BAH PF01426.18 CDW59043.1 - 1.3e-26 92.8 0.8 6.6e-15 55.0 0.1 2.6 2 0 0 2 2 2 2 BAH domain HMG_box PF00505.19 CDW59043.1 - 3.2e-12 46.7 0.3 8.6e-12 45.3 0.3 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW59043.1 - 6.7e-07 29.8 0.5 1.8e-06 28.4 0.5 1.7 1 0 0 1 1 1 1 HMG-box domain HTH_24 PF13412.6 CDW59043.1 - 0.023 14.3 0.0 2.2 7.9 0.1 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding FOXP-CC PF16159.5 CDW59043.1 - 0.036 14.7 3.2 0.24 12.1 0.4 2.7 2 0 0 2 2 2 0 FOXP coiled-coil domain DUF3761 PF12587.8 CDW59043.1 - 0.11 12.9 0.2 0.29 11.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) zf-C2H2 PF00096.26 CDW59043.1 - 0.68 10.5 10.0 0.58 10.7 0.6 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type RNA_pol_N PF01194.17 CDW59043.1 - 3.6 8.0 11.6 0.3 11.4 0.2 4.0 3 1 0 3 3 3 0 RNA polymerases N / 8 kDa subunit DUF386 PF04074.12 CDW59044.1 - 4.1e-17 62.5 0.1 4.3e-17 62.4 0.1 1.0 1 0 0 1 1 1 1 YhcH/YjgK/YiaL Cupin_2 PF07883.11 CDW59044.1 - 0.0012 18.5 0.0 0.0016 18.1 0.0 1.3 1 0 0 1 1 1 1 Cupin domain GATase_2 PF00310.21 CDW59045.1 - 1e-176 587.8 0.0 1.3e-176 587.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CDW59045.1 - 6.6e-158 525.6 0.0 1.1e-157 524.9 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CDW59045.1 - 3.2e-105 351.6 0.1 6e-105 350.7 0.0 1.5 2 0 0 2 2 1 1 Glutamate synthase central domain GXGXG PF01493.19 CDW59045.1 - 1e-74 250.3 7.8 1.8e-74 249.5 6.8 1.9 2 0 0 2 2 2 1 GXGXG motif Fer4_20 PF14691.6 CDW59045.1 - 2.7e-37 127.0 0.4 4.8e-37 126.2 0.4 1.4 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 CDW59045.1 - 7.5e-30 104.2 3.4 4.1e-25 88.6 1.4 1.8 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDW59045.1 - 1.2e-11 45.0 3.2 1.6e-05 25.3 0.3 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW59045.1 - 9.5e-11 41.5 0.3 6.8e-05 22.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW59045.1 - 3.5e-09 36.8 0.3 8.6e-08 32.3 0.1 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CDW59045.1 - 5.8e-06 25.8 0.1 1.1e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CDW59045.1 - 1.3e-05 24.5 0.1 3.5e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 CDW59045.1 - 5e-05 22.8 0.0 9.9e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CDW59045.1 - 8.4e-05 23.0 0.7 0.12 12.8 0.1 3.2 2 1 0 2 2 2 1 Putative NAD(P)-binding FMN_dh PF01070.18 CDW59045.1 - 8.9e-05 21.7 0.4 8.9e-05 21.7 0.4 2.3 3 0 0 3 3 3 1 FMN-dependent dehydrogenase HI0933_like PF03486.14 CDW59045.1 - 9.8e-05 21.2 0.1 0.00017 20.5 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 CDW59045.1 - 0.00035 20.3 1.3 0.013 15.1 0.2 2.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FMO-like PF00743.19 CDW59045.1 - 0.00044 18.8 0.1 0.0059 15.1 0.0 2.2 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Shikimate_DH PF01488.20 CDW59045.1 - 0.0009 19.3 0.1 1.7 8.7 0.0 2.7 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CDW59045.1 - 0.00091 18.6 0.1 0.0047 16.3 0.0 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 CDW59045.1 - 0.0013 17.8 1.5 0.013 14.6 0.3 2.3 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 CDW59045.1 - 0.011 15.1 1.6 0.37 10.0 0.2 2.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CDW59045.1 - 0.029 14.4 0.4 0.33 10.9 0.2 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding F420_oxidored PF03807.17 CDW59045.1 - 0.03 14.9 0.1 15 6.3 0.1 3.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 CDW59045.1 - 0.047 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K_oxygenase PF13434.6 CDW59045.1 - 0.16 11.1 0.0 14 4.7 0.0 2.4 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Fer4_6 PF12837.7 CDW59045.1 - 0.54 10.4 1.6 1.7 8.9 1.6 1.8 1 0 0 1 1 1 0 4Fe-4S binding domain Radical_SAM_C PF16199.5 CDW59046.1 - 2.2e-17 62.9 0.0 4.2e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CDW59046.1 - 1.8e-15 57.7 0.0 3e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily HATPase_c PF02518.26 CDW59047.1 - 1.6e-31 109.1 0.1 4.3e-31 107.7 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HKR_ArcB_TM PF18415.1 CDW59047.1 - 3.3e-30 104.7 6.4 3.3e-30 104.7 6.4 1.9 1 1 1 2 2 2 1 Histidine kinase receptor ArcB trans-membrane domain Response_reg PF00072.24 CDW59047.1 - 2.9e-22 78.9 0.2 6.4e-22 77.9 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain PAS PF00989.25 CDW59047.1 - 3.6e-18 65.6 0.0 1.2e-17 63.9 0.0 2.0 2 0 0 2 2 1 1 PAS fold HisKA PF00512.25 CDW59047.1 - 5.4e-16 58.4 2.9 3.4e-15 55.8 0.1 2.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 CDW59047.1 - 3.2e-15 56.3 0.0 1.7e-14 54.0 0.0 2.2 2 0 0 2 2 2 1 PAS fold Hpt PF01627.23 CDW59047.1 - 1.6e-11 44.3 1.6 1.7e-10 41.0 0.0 2.8 2 1 0 2 2 2 1 Hpt domain HATPase_c_3 PF13589.6 CDW59047.1 - 9.8e-07 28.7 0.0 2.2e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 CDW59047.1 - 2.7e-05 24.4 0.0 9e-05 22.7 0.0 2.0 1 0 0 1 1 1 1 PAS domain CCB1 PF12046.8 CDW59047.1 - 0.0011 18.3 1.3 0.0021 17.4 1.3 1.4 1 0 0 1 1 1 1 Cofactor assembly of complex C subunit B PAS_8 PF13188.7 CDW59047.1 - 0.005 16.8 0.0 0.026 14.6 0.0 2.3 2 0 0 2 2 2 1 PAS domain SLATT_4 PF18186.1 CDW59047.1 - 0.046 13.4 1.7 0.16 11.6 1.4 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 HATPase_c_5 PF14501.6 CDW59047.1 - 0.063 13.2 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 GHKL domain DUF1359 PF07097.11 CDW59047.1 - 1.4 9.2 5.6 2.1 8.6 1.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1359) Spc7 PF08317.11 CDW59047.1 - 1.5 7.6 12.3 0.33 9.8 8.5 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 CDW59047.1 - 2.1 8.4 5.5 5.3 7.1 5.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.15 CDW59047.1 - 6.4 6.6 9.9 10 5.9 4.4 2.9 1 1 1 2 2 2 0 Septum formation initiator DJ-1_PfpI PF01965.24 CDW59048.1 - 0.00013 21.8 0.0 0.00045 20.0 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family Catalase_C PF18011.1 CDW59048.1 - 0.011 15.4 0.0 0.026 14.1 0.0 1.6 2 0 0 2 2 2 0 C-terminal domain found in long catalases Transgly PF00912.22 CDW59049.1 - 1.3e-42 145.3 0.0 1.7e-42 144.9 0.0 1.0 1 0 0 1 1 1 1 Transglycosylase YrbL-PhoP_reg PF10707.9 CDW59050.1 - 4.5e-63 212.4 0.0 6.6e-63 211.9 0.0 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase PF00069.25 CDW59050.1 - 0.0013 18.1 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain ATP_bind_2 PF03668.15 CDW59051.1 - 9.4e-108 359.8 0.1 1.2e-107 359.5 0.1 1.1 1 0 0 1 1 1 1 P-loop ATPase protein family PTS-HPr PF00381.19 CDW59051.1 - 5.1e-12 45.9 0.1 9.5e-12 45.0 0.1 1.4 1 0 0 1 1 1 1 PTS HPr component phosphorylation site AAA_28 PF13521.6 CDW59051.1 - 0.026 14.8 0.0 0.058 13.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW59051.1 - 0.042 14.4 0.0 0.41 11.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 CDW59051.1 - 0.047 13.5 0.0 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 CDW59051.1 - 0.063 13.7 0.2 0.16 12.3 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 CDW59051.1 - 0.078 12.3 1.3 0.13 11.6 0.2 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 CDW59051.1 - 0.13 11.5 0.0 0.25 10.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_33 PF13671.6 CDW59051.1 - 0.14 12.4 0.0 0.45 10.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDW59051.1 - 0.15 12.3 0.1 0.33 11.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain Ribosomal_S30AE PF02482.19 CDW59052.1 - 4.5e-27 94.6 0.9 5.1e-27 94.5 0.9 1.0 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein ABC_tran PF00005.27 CDW59053.1 - 5e-34 117.8 0.0 7.8e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter BCA_ABC_TP_C PF12399.8 CDW59053.1 - 1.1e-07 31.6 0.0 2.1e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Branched-chain amino acid ATP-binding cassette transporter AAA_21 PF13304.6 CDW59053.1 - 0.00038 20.4 2.0 0.13 12.0 0.1 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 CDW59053.1 - 0.0096 15.0 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein SMC_N PF02463.19 CDW59053.1 - 0.011 15.2 0.1 3.5 7.0 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CDW59053.1 - 0.032 14.4 0.3 0.66 10.3 0.3 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CDW59053.1 - 0.057 13.9 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Na_Ca_ex PF01699.24 CDW59054.1 - 6e-50 169.1 29.6 2.8e-27 95.5 13.1 2.6 3 0 0 3 3 3 2 Sodium/calcium exchanger protein SIS PF01380.22 CDW59054.1 - 1.7e-35 121.8 0.1 5e-35 120.2 0.0 1.9 2 0 0 2 2 2 1 SIS domain CBS PF00571.28 CDW59054.1 - 2.3e-11 44.0 5.6 6.2e-05 23.4 0.2 3.3 3 1 0 3 3 3 2 CBS domain Hydrolase_3 PF08282.12 CDW59054.1 - 5.5e-11 42.7 0.0 4.3e-10 39.7 0.0 2.1 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDW59054.1 - 0.024 14.7 0.0 0.13 12.3 0.0 2.2 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW59054.1 - 0.028 14.7 0.1 0.29 11.4 0.0 2.6 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase SIS_2 PF13580.6 CDW59054.1 - 0.07 13.1 0.3 0.28 11.2 0.0 2.1 1 1 1 2 2 2 0 SIS domain DUF2529 PF10740.9 CDW59054.1 - 0.081 12.6 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) S6PP PF05116.13 CDW59054.1 - 0.12 11.9 0.0 0.97 8.9 0.0 2.4 3 0 0 3 3 3 0 Sucrose-6F-phosphate phosphohydrolase ABC_tran PF00005.27 CDW59055.1 - 8.7e-29 100.8 0.0 1.1e-28 100.4 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW59055.1 - 2.6e-08 34.0 0.0 0.003 17.4 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CDW59055.1 - 0.00056 19.9 0.0 0.00084 19.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 CDW59055.1 - 0.0013 18.4 0.1 0.005 16.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW59055.1 - 0.0013 19.1 0.0 0.0018 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 CDW59055.1 - 0.003 16.4 2.5 0.49 9.1 0.3 2.5 2 1 1 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 CDW59055.1 - 0.0035 17.6 0.0 0.0063 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW59055.1 - 0.0057 16.4 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 CDW59055.1 - 0.022 15.3 0.6 0.03 14.8 0.6 1.1 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CDW59055.1 - 0.025 14.8 0.2 2.1 8.6 0.2 2.5 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 CDW59055.1 - 0.026 14.3 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CDW59055.1 - 0.032 14.1 0.0 0.071 13.0 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CDW59055.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDW59055.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 CDW59055.1 - 0.13 12.7 0.0 0.37 11.2 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MlaE PF02405.16 CDW59056.1 - 1.3e-68 230.8 15.6 2.4e-68 230.0 15.6 1.4 1 0 0 1 1 1 1 Permease MlaE MlaC PF05494.12 CDW59056.1 - 5.1e-48 163.0 0.1 8.2e-48 162.3 0.1 1.3 1 0 0 1 1 1 1 MlaC protein MlaD PF02470.20 CDW59056.1 - 6.9e-21 74.3 0.0 1.5e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 MlaD protein STAS_2 PF13466.6 CDW59056.1 - 1.4e-12 47.8 0.6 4.3e-12 46.2 0.6 1.9 1 0 0 1 1 1 1 STAS domain BolA PF01722.18 CDW59056.1 - 3.4e-12 46.4 0.0 7.3e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 BolA-like protein STAS PF01740.21 CDW59056.1 - 0.028 14.1 0.0 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 STAS domain EPSP_synthase PF00275.20 CDW59057.1 - 5.1e-131 437.2 0.7 5.9e-131 437.0 0.7 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Phage_gp49_66 PF13876.6 CDW59057.1 - 0.018 15.4 0.1 0.038 14.3 0.1 1.5 1 0 0 1 1 1 0 Phage protein (N4 Gp49/phage Sf6 gene 66) family Hexapep PF00132.24 CDW59057.1 - 0.072 12.8 1.3 13 5.7 0.0 3.6 3 0 0 3 3 3 0 Bacterial transferase hexapeptide (six repeats) polyprenyl_synt PF00348.17 CDW59058.1 - 4.1e-77 258.7 0.0 4.9e-77 258.5 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase UbiA PF01040.18 CDW59058.1 - 0.12 11.7 0.1 0.48 9.7 0.1 1.9 2 0 0 2 2 2 0 UbiA prenyltransferase family NAC PF01849.18 CDW59059.1 - 0.035 14.1 0.0 0.048 13.6 0.0 1.2 1 0 0 1 1 1 0 NAC domain HLH PF00010.26 CDW59062.1 - 2.2e-16 59.5 1.7 3.4e-16 58.9 1.7 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Neuro_bHLH PF12533.8 CDW59062.1 - 1.6e-13 52.0 2.0 3.6e-13 50.8 1.1 2.1 1 1 1 2 2 2 1 Neuronal helix-loop-helix transcription factor MBOAT PF03062.19 CDW59063.1 - 0.00014 21.3 24.4 0.0014 18.1 8.2 2.6 1 1 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family Clathrin PF00637.20 CDW59064.1 - 0.0023 17.8 16.5 10 6.0 0.2 7.7 5 2 2 8 8 8 2 Region in Clathrin and VPS Nic96 PF04097.14 CDW59064.1 - 0.011 14.3 5.0 0.34 9.3 0.0 3.8 2 1 2 4 4 4 0 Nup93/Nic96 VHS PF00790.19 CDW59064.1 - 0.028 14.3 0.8 0.17 11.7 0.1 2.8 3 0 0 3 3 3 0 VHS domain TPR_7 PF13176.6 CDW59064.1 - 0.041 13.9 19.8 0.21 11.7 0.0 8.4 9 1 0 9 9 9 0 Tetratricopeptide repeat PPR PF01535.20 CDW59064.1 - 0.12 12.7 7.7 17 6.0 0.1 6.4 8 1 1 9 9 9 0 PPR repeat TPR_17 PF13431.6 CDW59064.1 - 0.76 10.3 10.2 13 6.4 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW59064.1 - 1.4 9.4 13.0 32 5.1 0.1 6.9 8 0 0 8 8 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW59064.1 - 1.8 8.8 16.8 17 5.7 0.0 6.9 5 2 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CDW59064.1 - 5.4 6.8 12.0 5 6.9 0.2 6.2 8 0 0 8 8 8 0 TPR repeat TPR_2 PF07719.17 CDW59064.1 - 9.4 6.6 26.7 0.26 11.5 0.4 8.4 9 2 2 11 11 11 0 Tetratricopeptide repeat MBF1 PF08523.10 CDW59065.1 - 2.1e-17 63.3 2.9 2.1e-17 63.3 2.9 2.1 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 CDW59065.1 - 5e-10 39.3 0.6 8.7e-10 38.5 0.6 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CDW59065.1 - 3.4e-05 24.1 0.1 6.9e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 CDW59065.1 - 0.0049 16.9 0.5 0.0085 16.1 0.5 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 CDW59065.1 - 0.011 15.7 0.6 0.025 14.6 0.3 1.7 1 1 1 2 2 2 0 Helix-turn-helix domain TetR_C_27 PF17935.1 CDW59065.1 - 0.062 13.4 0.2 0.087 12.9 0.2 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Transmemb_17 PF09799.9 CDW59066.1 - 3.1e-18 66.3 10.7 4.2e-18 65.9 10.7 1.3 1 0 0 1 1 1 1 Predicted membrane protein Lactamase_B_2 PF12706.7 CDW59067.1 - 4.2e-39 134.2 0.0 5.8e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDW59067.1 - 1.4e-09 38.0 0.0 2.1e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDW59067.1 - 0.17 11.8 2.9 0.24 11.4 0.7 2.1 3 0 0 3 3 3 0 Metallo-beta-lactamase superfamily PP2C PF00481.21 CDW59068.1 - 1.8e-55 188.4 0.0 3.5e-55 187.4 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CDW59068.1 - 0.007 16.0 0.0 0.018 14.7 0.0 1.6 1 0 0 1 1 1 1 Protein phosphatase 2C DprA_WH PF17782.1 CDW59068.1 - 0.19 11.9 0.0 0.52 10.5 0.0 1.8 2 0 0 2 2 2 0 DprA winged helix domain zf-CCHC_3 PF13917.6 CDW59069.1 - 1.4e-06 28.2 0.0 2.9e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Zinc knuckle FAM101 PF15068.6 CDW59069.1 - 0.0099 15.9 0.5 0.012 15.5 0.5 1.2 1 0 0 1 1 1 1 FAM101 family DUF4718 PF15842.5 CDW59069.1 - 0.047 13.5 5.4 0.061 13.1 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) SR-25 PF10500.9 CDW59069.1 - 0.068 12.8 25.1 0.081 12.5 25.1 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CDW59069.1 - 0.37 10.5 10.4 0.55 9.9 10.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 RNase_P_Rpp14 PF01900.19 CDW59070.1 - 1.9e-13 50.5 0.2 2.4e-13 50.2 0.2 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family RNA_pol_Rpc34 PF05158.12 CDW59071.1 - 7.7e-43 147.2 4.3 6.1e-41 140.9 4.3 2.6 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit SMC_Nse1 PF07574.13 CDW59071.1 - 0.0024 17.8 0.1 0.41 10.5 0.0 2.3 2 1 0 2 2 2 2 Nse1 non-SMC component of SMC5-6 complex TrmB PF01978.19 CDW59071.1 - 0.066 13.1 0.5 0.57 10.1 0.1 2.6 2 1 1 3 3 3 0 Sugar-specific transcriptional regulator TrmB Pyridoxal_deC PF00282.19 CDW59073.1 - 1.4e-114 382.8 0.0 1.6e-114 382.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CDW59073.1 - 0.005 15.9 0.0 0.011 14.7 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V CCP_MauG PF03150.14 CDW59074.1 - 1.4e-51 175.1 0.0 3.1e-47 161.0 0.0 3.1 3 0 0 3 3 3 2 Di-haem cytochrome c peroxidase Haem_bd PF14376.6 CDW59074.1 - 5.9e-34 116.9 4.0 4.2e-33 114.1 0.0 2.9 3 0 0 3 3 3 1 Haem-binding domain Cytochrom_C PF00034.21 CDW59074.1 - 7.6e-14 52.6 0.1 2.5e-07 31.8 0.0 3.9 3 1 0 3 3 3 2 Cytochrome c Cytochrome_CBB3 PF13442.6 CDW59074.1 - 1e-05 25.8 13.1 0.033 14.5 0.0 5.4 4 2 0 4 4 4 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrome_C7 PF14522.6 CDW59074.1 - 0.00057 19.8 0.1 4.6 7.3 0.0 3.2 3 0 0 3 3 3 1 Cytochrome c7 and related cytochrome c DUF1924 PF09086.11 CDW59074.1 - 0.014 15.7 0.2 5.2 7.5 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1924) Paired_CXXCH_1 PF09699.10 CDW59074.1 - 0.015 15.0 2.0 15 5.4 0.0 3.4 3 0 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) CHASE PF03924.13 CDW59074.1 - 0.058 13.3 0.2 0.12 12.3 0.2 1.4 1 0 0 1 1 1 0 CHASE domain Cytochrom_c3_2 PF14537.6 CDW59074.1 - 0.11 13.0 2.3 41 4.7 0.1 3.2 3 0 0 3 3 3 0 Cytochrome c3 COX8 PF02285.15 CDW59074.1 - 0.13 12.2 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIII PSCyt3 PF07627.11 CDW59074.1 - 0.17 12.2 0.3 13 6.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1588) VRP3 PF03536.15 CDW59074.1 - 0.19 11.2 0.0 0.31 10.5 0.0 1.2 1 0 0 1 1 1 0 Salmonella virulence-associated 28kDa protein Trehalase PF01204.18 CDW59075.1 - 1.1e-166 555.7 0.1 1.3e-166 555.4 0.1 1.0 1 0 0 1 1 1 1 Trehalase Bac_rhamnosid6H PF17389.2 CDW59075.1 - 0.00039 19.8 0.0 0.00067 19.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF346 PF03984.13 CDW59075.1 - 0.043 13.6 0.1 0.043 13.6 0.1 1.9 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) Glyco_hydro_63 PF03200.16 CDW59075.1 - 0.045 12.5 0.1 0.097 11.4 0.0 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 63 C-terminal domain GerE PF00196.19 CDW59076.1 - 4.1e-21 74.3 1.0 6.4e-21 73.7 1.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 CDW59076.1 - 8.4e-09 35.0 0.2 1.7e-08 34.0 0.2 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4 PF04545.16 CDW59076.1 - 1.9e-06 27.3 0.4 4.1e-06 26.2 0.4 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_38 PF13936.6 CDW59076.1 - 1.5e-05 24.7 0.2 4.7e-05 23.1 0.2 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDW59076.1 - 0.00012 21.8 0.1 0.00049 19.8 0.0 1.9 1 1 1 2 2 2 1 Homeodomain-like domain HTH_24 PF13412.6 CDW59076.1 - 0.00019 20.9 0.2 0.00036 20.0 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 CDW59076.1 - 0.0015 18.3 0.2 0.017 14.9 0.2 2.2 1 1 0 1 1 1 1 LexA DNA binding domain HTH_11 PF08279.12 CDW59076.1 - 0.0016 18.3 0.8 0.017 15.1 0.2 2.3 2 0 0 2 2 2 1 HTH domain DUF2089 PF09862.9 CDW59076.1 - 0.0041 17.1 0.0 0.0072 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) HTH_28 PF13518.6 CDW59076.1 - 0.011 15.8 0.0 0.03 14.4 0.0 1.8 1 1 1 2 2 2 0 Helix-turn-helix domain HTH_7 PF02796.15 CDW59076.1 - 0.013 15.6 0.0 0.032 14.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_5 PF01022.20 CDW59076.1 - 0.018 14.9 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Sigma70_ECF PF07638.11 CDW59076.1 - 0.03 14.2 0.1 0.055 13.4 0.1 1.5 1 1 0 1 1 1 0 ECF sigma factor HTH_20 PF12840.7 CDW59076.1 - 0.039 14.0 0.2 0.069 13.2 0.2 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_AsnC-type PF13404.6 CDW59076.1 - 0.074 12.9 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain NUMOD1 PF07453.13 CDW59076.1 - 0.17 12.2 0.1 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 NUMOD1 domain LysR_substrate PF03466.20 CDW59077.1 - 2.9e-43 147.7 0.2 3.9e-43 147.2 0.2 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDW59077.1 - 3.2e-18 65.4 0.4 5.5e-18 64.7 0.4 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family Sugar_tr PF00083.24 CDW59078.1 - 3.5e-32 111.9 30.5 1.8e-24 86.5 7.5 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CDW59078.1 - 3.1e-29 102.0 60.2 1.5e-16 60.3 27.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AsmA PF05170.14 CDW59079.1 - 3.8e-187 623.8 0.0 4.3e-187 623.6 0.0 1.0 1 0 0 1 1 1 1 AsmA family AsmA_2 PF13502.6 CDW59079.1 - 4.4e-16 59.1 3.8 7.3e-15 55.1 1.8 3.0 2 1 1 3 3 3 1 AsmA-like C-terminal region DUF748 PF05359.11 CDW59079.1 - 0.0035 17.5 0.1 0.68 10.1 0.0 3.7 4 1 0 4 4 4 1 Domain of Unknown Function (DUF748) EAL PF00563.20 CDW59080.1 - 5.3e-30 104.7 0.0 7.1e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 EAL domain PfkB PF00294.24 CDW59081.1 - 1.4e-74 251.1 0.0 1.6e-74 250.9 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase RAMP PF04901.13 CDW59081.1 - 0.2 11.7 0.0 0.44 10.6 0.0 1.5 2 0 0 2 2 2 0 Receptor activity modifying family Peptidase_M16_C PF05193.21 CDW59082.1 - 8.2e-19 68.3 0.0 2.1e-18 67.0 0.0 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CDW59082.1 - 3e-06 27.3 0.0 8.4e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) SDF PF00375.18 CDW59083.1 - 7.2e-112 374.2 40.9 8.1e-112 374.1 40.9 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family EAL PF00563.20 CDW59084.1 - 4.1e-60 203.3 0.6 8.6e-60 202.2 0.1 1.8 2 0 0 2 2 2 1 EAL domain GAPES3 PF17154.4 CDW59084.1 - 2.3e-49 166.3 0.7 5.8e-49 165.1 0.7 1.7 1 0 0 1 1 1 1 Gammaproteobacterial periplasmic sensor domain GGDEF PF00990.21 CDW59084.1 - 7.5e-12 45.3 0.0 2.8e-11 43.4 0.0 2.0 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain HAMP PF00672.25 CDW59084.1 - 8.4e-06 26.1 1.6 1.2e-05 25.6 0.1 2.1 2 0 0 2 2 2 1 HAMP domain CHASE8 PF17152.4 CDW59084.1 - 0.0027 17.9 2.2 0.016 15.4 0.0 3.3 5 0 0 5 5 5 1 Periplasmic sensor domain DUF588 PF04535.12 CDW59084.1 - 0.043 13.6 0.0 0.043 13.6 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF588) BCSC_C PF05420.11 CDW59085.1 - 2.8e-47 161.5 5.5 3.3e-36 125.1 0.9 2.7 2 1 1 3 3 3 2 Cellulose synthase operon protein C C-terminus (BCSC_C) TPR_19 PF14559.6 CDW59085.1 - 1.9e-33 114.8 55.8 6e-07 29.9 7.9 11.4 8 2 4 12 12 12 8 Tetratricopeptide repeat TPR_2 PF07719.17 CDW59085.1 - 1.8e-18 65.1 32.1 7.7e-05 22.5 0.2 12.0 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_16 PF13432.6 CDW59085.1 - 8.3e-18 64.8 74.3 8.7e-07 29.5 4.4 11.2 11 1 1 12 12 12 5 Tetratricopeptide repeat TPR_14 PF13428.6 CDW59085.1 - 5e-17 61.2 52.4 0.014 16.1 0.5 14.3 10 4 4 14 14 14 6 Tetratricopeptide repeat TPR_8 PF13181.6 CDW59085.1 - 1.7e-13 49.6 12.2 9.6e-06 25.4 0.1 10.0 11 0 0 11 11 11 1 Tetratricopeptide repeat TPR_12 PF13424.6 CDW59085.1 - 8.8e-11 41.9 40.2 0.0053 17.0 0.3 10.3 8 2 0 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.6 CDW59085.1 - 1.1e-10 40.7 21.6 0.00016 21.5 0.1 8.9 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 CDW59085.1 - 4.3e-09 35.8 21.7 9.3e-05 22.1 0.1 8.1 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_20 PF14561.6 CDW59085.1 - 1.4e-07 31.8 32.8 0.00022 21.5 0.9 8.3 6 3 3 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDW59085.1 - 3.9e-05 23.2 27.2 0.0088 15.7 0.2 8.6 9 1 1 10 10 10 3 TPR repeat RPN7 PF10602.9 CDW59085.1 - 0.00014 21.6 1.2 0.12 12.1 0.0 4.1 4 1 1 5 5 5 1 26S proteasome subunit RPN7 TPR_15 PF13429.6 CDW59085.1 - 0.00016 21.0 49.5 0.13 11.5 16.4 7.0 2 1 6 8 8 8 3 Tetratricopeptide repeat BTAD PF03704.17 CDW59085.1 - 0.00088 19.7 0.5 0.00088 19.7 0.5 7.1 6 1 2 8 8 8 1 Bacterial transcriptional activator domain TPR_17 PF13431.6 CDW59085.1 - 0.0015 18.7 22.2 0.026 14.9 0.1 8.3 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW59085.1 - 0.0047 17.5 52.9 1.3 9.8 0.4 12.2 12 1 0 12 12 12 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW59085.1 - 0.0065 16.6 38.4 0.18 12.0 0.0 9.7 6 4 3 10 10 9 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDW59085.1 - 0.021 14.7 43.8 0.059 13.3 1.1 10.2 10 0 0 10 10 10 0 Tetratricopeptide repeat TOM20_plant PF06552.12 CDW59085.1 - 0.038 13.7 0.3 2.9 7.6 0.0 3.1 1 1 2 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 PDGF_N PF04692.13 CDW59085.1 - 0.19 12.6 0.8 0.77 10.6 0.2 2.3 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region Glyco_hydro_8 PF01270.17 CDW59086.1 - 3.6e-146 486.3 2.9 4.2e-146 486.1 2.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 8 BcsB PF03170.13 CDW59087.1 - 1.5e-221 737.0 1.0 1.7e-221 736.8 1.0 1.0 1 0 0 1 1 1 1 Bacterial cellulose synthase subunit Glyco_trans_2_3 PF13632.6 CDW59088.1 - 7.9e-16 58.6 0.6 7.9e-16 58.6 0.6 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.14 CDW59088.1 - 1.3e-13 50.4 2.7 2.6e-13 49.4 2.4 1.6 1 1 1 2 2 2 1 Cellulose synthase PilZ PF07238.14 CDW59088.1 - 9.6e-13 48.3 0.1 1.8e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 PilZ domain Glyco_tranf_2_3 PF13641.6 CDW59088.1 - 4.5e-08 33.3 0.0 6.7e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CDW59088.1 - 8e-08 32.3 0.0 1.4e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CDW59088.1 - 3.2e-07 30.0 0.0 5.4e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Insulin_TMD PF17870.1 CDW59088.1 - 0.82 9.8 2.8 4.6 7.4 0.2 2.7 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Innexin PF00876.18 CDW59089.1 - 3.2e-45 155.0 3.7 4e-45 154.6 3.7 1.1 1 0 0 1 1 1 1 Innexin Ribosomal_L18 PF17135.4 CDW59090.1 - 3.3e-72 241.8 1.7 3.7e-72 241.6 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 CDW59090.1 - 0.042 14.5 0.1 0.11 13.2 0.1 1.8 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RRM_1 PF00076.22 CDW59091.1 - 3.3e-10 39.7 0.0 4.6e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW59091.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Spermine_synt_N PF17284.2 CDW59091.1 - 0.18 11.7 0.0 0.39 10.6 0.0 1.6 1 1 0 1 1 1 0 Spermidine synthase tetramerisation domain ATP-synt_ab PF00006.25 CDW59092.1 - 0.2 11.3 0.0 4.6 6.8 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain TrbI PF03743.14 CDW59094.1 - 0.0035 17.2 0.4 0.012 15.5 0.4 1.9 1 1 0 1 1 1 1 Bacterial conjugation TrbI-like protein LAMTOR PF15454.6 CDW59094.1 - 0.16 12.6 2.5 0.48 11.1 2.5 1.8 1 0 0 1 1 1 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF1664 PF07889.12 CDW59094.1 - 0.83 9.7 2.3 1.9 8.6 2.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) T4BSS_DotH_IcmK PF12293.8 CDW59095.1 - 1.4e-58 198.0 0.4 1.9e-58 197.5 0.4 1.2 1 0 0 1 1 1 1 Putative outer membrane core complex of type IVb secretion T4BSS_DotI_IcmL PF11393.8 CDW59095.1 - 6.1e-24 84.5 0.0 1.1e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Type-IV b secretion system, inner-membrane complex component LPD7 PF18821.1 CDW59096.1 - 4.6e-12 45.9 0.0 1.7e-11 44.1 0.0 2.0 1 0 0 1 1 1 1 Large polyvalent protein-associated domain 7 T2SSE PF00437.20 CDW59097.1 - 7.8e-33 113.7 0.0 1e-32 113.3 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 CDW59097.1 - 0.00024 21.4 0.0 0.00054 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 CDW59097.1 - 0.002 18.7 0.1 0.0044 17.5 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CDW59097.1 - 0.0024 18.3 0.1 0.0057 17.0 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 CDW59097.1 - 0.0029 18.1 0.0 0.0055 17.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 CDW59097.1 - 0.0055 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 CDW59097.1 - 0.0075 16.7 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 CDW59097.1 - 0.017 14.7 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 CDW59097.1 - 0.072 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain Sigma54_activat PF00158.26 CDW59097.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Ploopntkinase3 PF18751.1 CDW59097.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 NACHT PF05729.12 CDW59097.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain T4SS_TraI PF16932.5 CDW59098.1 - 4.4e-73 244.9 3.2 5.3e-73 244.7 3.2 1.1 1 0 0 1 1 1 1 Type IV secretory system, conjugal DNA-protein transfer DotD PF16816.5 CDW59099.1 - 1.7e-17 63.5 0.0 2e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 DotD protein TraF_2 PF13729.6 CDW59100.1 - 8.5e-66 222.2 5.4 1e-65 221.9 5.4 1.1 1 0 0 1 1 1 1 F plasmid transfer operon, TraF, protein OMP_b-brl PF13505.6 CDW59100.1 - 0.053 13.7 7.0 0.59 10.2 2.4 2.4 2 1 0 2 2 2 0 Outer membrane protein beta-barrel domain Shufflon_N PF04917.12 CDW59102.1 - 2.1e-99 333.0 17.5 1.6e-57 195.4 0.9 2.2 1 1 1 2 2 2 2 Bacterial shufflon protein, N-terminal constant region Collar PF07484.12 CDW59102.1 - 1.3e-12 47.5 0.2 5e-12 45.7 0.2 2.1 1 0 0 1 1 1 1 Phage Tail Collar Domain N_methyl PF07963.12 CDW59102.1 - 0.015 14.8 0.0 0.036 13.6 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic N-terminal methylation motif S_tail_recep_bd PF14928.6 CDW59102.1 - 0.055 14.1 0.1 0.23 12.1 0.0 2.1 2 0 0 2 2 2 0 Short tail fibre protein receptor-binding domain PilS PF08805.11 CDW59104.1 - 3.9e-15 55.9 5.3 6e-15 55.3 5.3 1.3 1 0 0 1 1 1 1 PilS N terminal T2SSF PF00482.23 CDW59104.1 - 9.8e-08 32.0 1.0 3.7e-05 23.7 0.0 2.9 3 0 0 3 3 3 2 Type II secretion system (T2SS), protein F N_methyl PF07963.12 CDW59104.1 - 4.5e-05 22.8 0.2 4.5e-05 22.8 0.2 2.2 2 0 0 2 2 2 1 Prokaryotic N-terminal methylation motif DUF1345 PF07077.11 CDW59104.1 - 0.0042 16.8 2.9 0.0075 16.0 0.3 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1345) PsaN PF05479.11 CDW59104.1 - 0.046 13.9 0.0 0.085 13.1 0.0 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) LapA_dom PF06305.11 CDW59104.1 - 0.061 13.2 1.9 0.085 12.7 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Phage_holin_3_6 PF07332.11 CDW59104.1 - 0.46 10.5 4.6 0.44 10.6 3.4 1.5 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III PAP_PilO PF06864.12 CDW59105.1 - 2.6e-51 174.8 0.0 3.3e-51 174.4 0.0 1.1 1 0 0 1 1 1 1 Pilin accessory protein (PilO) T2SSE PF00437.20 CDW59105.1 - 1.6e-36 125.8 0.0 2.6e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 CDW59105.1 - 7.9e-07 29.0 0.0 1.8e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW59105.1 - 0.00056 20.3 0.1 0.0017 18.7 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDW59105.1 - 0.0025 18.1 0.0 0.0059 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW59105.1 - 0.0092 15.7 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_19 PF13245.6 CDW59105.1 - 0.047 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TadE PF07811.12 CDW59105.1 - 0.061 13.6 0.2 0.14 12.4 0.2 1.6 1 0 0 1 1 1 0 TadE-like protein ABC_tran PF00005.27 CDW59105.1 - 0.081 13.4 0.0 0.32 11.5 0.0 2.0 2 0 0 2 2 2 0 ABC transporter AAA_11 PF13086.6 CDW59105.1 - 0.088 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDW59105.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 CDW59105.1 - 0.12 12.8 0.1 0.23 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF2614 PF11023.8 CDW59105.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain T2SSB PF16537.5 CDW59105.1 - 0.16 11.6 0.0 0.39 10.4 0.0 1.6 1 0 0 1 1 1 0 Type II secretion system protein B Secretin PF00263.21 CDW59106.1 - 2.6e-11 43.5 5.8 5.6e-11 42.4 5.8 1.6 1 1 0 1 1 1 1 Bacterial type II and III secretion system protein SSF PF00474.17 CDW59107.1 - 2e-23 83.0 22.2 2.4e-23 82.7 22.2 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family ALG11_N PF15924.5 CDW59107.1 - 1.3 9.1 6.1 6 6.9 3.3 2.2 2 0 0 2 2 2 0 ALG11 mannosyltransferase N-terminus Collagen PF01391.18 CDW59108.1 - 3.7e-25 87.4 81.0 5.8e-09 35.6 24.5 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW59108.1 - 0.00064 19.7 0.5 0.00087 19.3 0.5 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Myb_DNA-bind_7 PF15963.5 CDW59109.1 - 4e-05 23.4 0.1 8.8e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 Myb DNA-binding like MFS_1 PF07690.16 CDW59110.1 - 1.2e-29 103.4 35.9 1.9e-29 102.7 35.9 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4212 PF13937.6 CDW59110.1 - 0.018 15.4 0.2 0.09 13.2 0.2 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) Peptidase_S24 PF00717.23 CDW59112.1 - 4.7e-09 36.1 0.2 1.2e-08 34.8 0.2 1.7 1 0 0 1 1 1 1 Peptidase S24-like KH_6 PF15985.5 CDW59112.1 - 7.1e-09 35.9 0.0 1.4e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 KH domain Git3 PF11710.8 CDW59112.1 - 0.2 11.4 2.9 0.4 10.4 0.2 2.1 1 1 1 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 CDW59113.1 - 0.24 10.7 8.9 0.17 11.2 7.4 1.5 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF4293 PF14126.6 CDW59113.1 - 9.8 6.4 10.4 3.7 7.8 5.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4293) Trypsin PF00089.26 CDW59115.1 - 1.5e-22 80.5 0.0 9.4e-06 25.6 0.0 4.5 3 1 1 4 4 4 4 Trypsin Trypsin PF00089.26 CDW59116.1 - 2.6e-15 56.8 0.3 8.6e-05 22.4 0.0 4.2 3 1 1 4 4 4 4 Trypsin DUF2148 PF09918.9 CDW59117.1 - 0.00018 21.5 0.0 0.72 9.9 0.0 3.5 1 1 2 4 4 4 2 Uncharacterized protein containing a ferredoxin domain (DUF2148) SepRS_C PF18006.1 CDW59117.1 - 0.013 15.6 0.3 4.9 7.3 0.0 3.3 3 0 0 3 3 3 0 O-phosphoseryl-tRNA synthetase C-terminal domain Thioredoxin_8 PF13905.6 CDW59117.1 - 0.046 14.0 0.0 1.4 9.3 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin-like EAF PF09816.9 CDW59118.1 - 3.1e-18 66.0 0.1 5.9e-18 65.1 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Polyketide_cyc PF03364.20 CDW59119.1 - 3.2e-15 56.5 0.1 4.4e-15 56.0 0.1 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SF3b1 PF08920.10 CDW59120.1 - 4.3e-36 124.0 1.7 4.3e-36 124.0 1.7 4.4 1 1 2 3 3 3 2 Splicing factor 3B subunit 1 HEAT PF02985.22 CDW59120.1 - 5e-09 35.7 4.2 0.76 10.2 0.0 7.2 8 0 0 8 8 7 3 HEAT repeat HEAT_EZ PF13513.6 CDW59120.1 - 1.1e-06 29.0 9.1 0.65 10.6 0.0 7.3 8 1 0 8 8 7 2 HEAT-like repeat HEAT_2 PF13646.6 CDW59120.1 - 2.4e-06 27.8 2.9 0.11 12.9 0.0 5.9 4 2 2 6 6 6 1 HEAT repeats Cnd1 PF12717.7 CDW59120.1 - 4.3e-05 23.6 0.7 1.8 8.6 0.0 4.7 3 3 3 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CDW59120.1 - 0.00015 22.3 0.3 1.8 9.2 0.0 4.7 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 CDW59120.1 - 0.00027 20.9 1.3 0.9 9.4 0.1 3.8 3 0 0 3 3 3 2 Domain of unknown function (DUF3385) NUC173 PF08161.12 CDW59120.1 - 0.0011 18.7 0.2 1.9 8.1 0.0 4.4 5 1 1 6 6 6 1 NUC173 domain UME PF08064.13 CDW59120.1 - 0.0015 18.4 0.3 9.3 6.2 0.0 4.7 3 1 1 4 4 4 1 UME (NUC010) domain CLASP_N PF12348.8 CDW59120.1 - 0.0045 16.6 0.6 1.3 8.6 0.1 3.8 3 2 1 4 4 4 1 CLASP N terminal TAF6_C PF07571.13 CDW59120.1 - 0.0092 16.3 0.0 5 7.5 0.0 3.1 2 0 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain TIP120 PF08623.10 CDW59120.1 - 0.032 14.0 0.3 11 5.8 0.0 2.8 2 1 0 2 2 2 0 TATA-binding protein interacting (TIP20) DUF1428 PF07237.11 CDW59120.1 - 0.069 13.4 0.1 0.68 10.2 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1428) Ribosomal_S6e PF01092.19 CDW59121.1 - 7.3e-60 200.4 0.7 2.5e-59 198.7 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e Skp1 PF01466.19 CDW59121.1 - 0.14 12.3 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Skp1 family, dimerisation domain SH3_9 PF14604.6 CDW59123.1 - 5.9e-28 96.5 0.1 6.1e-15 54.8 0.1 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CDW59123.1 - 1.7e-18 66.0 0.3 2.2e-13 49.6 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 CDW59123.1 - 2.7e-18 65.4 0.0 2.8e-12 46.1 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain FOP_dimer PF09398.10 CDW59124.1 - 1.2e-06 28.7 0.0 3.4e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 FOP N terminal dimerisation domain Ribonuc_P_40 PF08584.11 CDW59124.1 - 0.045 13.0 0.0 0.084 12.1 0.0 1.4 1 1 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit 7TM_GPCR_Srab PF10292.9 CDW59125.1 - 1.7e-07 30.5 21.5 1.7e-07 30.5 21.5 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR receptor class ab chemoreceptor 7tm_1 PF00001.21 CDW59125.1 - 0.035 13.4 17.6 0.041 13.2 17.1 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) PH_10 PF15411.6 CDW59125.1 - 0.058 13.7 0.0 0.71 10.1 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain GWT1 PF06423.12 CDW59126.1 - 1.5e-13 51.2 0.8 1.5e-13 51.2 0.8 1.8 2 1 0 2 2 2 1 GWT1 CDC13_N PF16853.5 CDW59126.1 - 0.019 14.5 0.2 0.034 13.7 0.2 1.3 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus Tim17 PF02466.19 CDW59127.1 - 0.00057 20.2 0.6 0.001 19.4 0.6 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Collagen PF01391.18 CDW59128.1 - 5.8e-28 96.4 96.8 3.5e-10 39.5 31.3 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW59128.1 - 3.1e-11 43.2 0.3 3.8e-11 42.9 0.3 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Ig_3 PF13927.6 CDW59129.1 - 6.1e-32 110.0 1.4 9.6e-10 38.9 0.0 5.7 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 CDW59129.1 - 3.6e-28 97.5 0.0 2.6e-11 43.4 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW59129.1 - 5.4e-22 77.9 1.1 7.1e-05 23.1 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin domain fn3 PF00041.21 CDW59129.1 - 1.8e-20 73.1 3.0 1.4e-11 44.5 0.1 3.3 4 0 0 4 4 4 2 Fibronectin type III domain ig PF00047.25 CDW59129.1 - 6.2e-17 61.6 5.3 2.8e-05 24.2 0.0 5.0 5 0 0 5 5 5 3 Immunoglobulin domain V-set PF07686.17 CDW59129.1 - 5.5e-15 55.5 4.7 0.0012 19.0 0.7 6.1 4 2 1 5 5 5 4 Immunoglobulin V-set domain Ig_4 PF16680.5 CDW59129.1 - 2.4e-07 30.9 0.1 0.016 15.5 0.0 4.0 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 CDW59129.1 - 4.3e-06 26.7 0.5 0.014 15.5 0.0 4.3 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 CDW59129.1 - 2e-05 24.9 0.1 0.0085 16.5 0.0 4.0 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 CDW59129.1 - 5e-05 22.8 0.2 0.94 9.1 0.0 3.9 4 0 0 4 4 4 2 Immunoglobulin domain BiPBP_C PF06832.12 CDW59129.1 - 0.002 18.1 0.0 2.6 8.2 0.0 3.4 3 0 0 3 3 3 1 Penicillin-Binding Protein C-terminus Family Adeno_E3_CR1 PF02440.15 CDW59129.1 - 0.0064 16.2 0.0 0.11 12.3 0.0 2.8 3 0 0 3 3 3 1 Adenovirus E3 region protein CR1 Shisa PF13908.6 CDW59129.1 - 0.1 12.8 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 CDW59129.1 - 0.14 13.1 0.0 0.34 11.8 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PCI PF01399.27 CDW59130.1 - 2.7e-14 53.5 0.1 1.4e-13 51.3 0.0 2.4 3 0 0 3 3 3 1 PCI domain PPR PF01535.20 CDW59130.1 - 0.86 10.0 4.7 36 4.9 0.3 4.9 5 0 0 5 5 5 0 PPR repeat Trypsin PF00089.26 CDW59132.1 - 6.2e-55 186.4 0.1 8.4e-55 186.0 0.1 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW59132.1 - 0.00011 23.1 0.0 0.00018 22.4 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW59132.1 - 0.0099 16.3 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1986) TACC_C PF05010.14 CDW59133.1 - 2.8e-36 125.2 26.2 4.3e-36 124.6 26.2 1.2 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Filament PF00038.21 CDW59133.1 - 0.00018 21.2 10.9 0.00018 21.2 10.9 3.0 1 1 2 3 3 3 2 Intermediate filament protein UPF0242 PF06785.11 CDW59133.1 - 0.002 18.2 24.7 0.0051 16.9 7.4 2.3 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus Hemerythrin PF01814.23 CDW59133.1 - 0.015 15.9 0.9 0.044 14.4 0.4 2.0 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain Tup_N PF08581.10 CDW59133.1 - 0.02 15.2 16.8 0.9 9.9 2.2 4.9 2 1 3 5 5 5 0 Tup N-terminal TPR_MLP1_2 PF07926.12 CDW59133.1 - 0.025 14.6 31.1 0.056 13.5 4.3 4.2 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 CDW59133.1 - 0.025 13.9 29.8 0.82 9.0 12.1 2.6 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding bZIP_2 PF07716.15 CDW59133.1 - 0.032 14.3 1.4 0.032 14.3 1.4 4.2 4 1 1 5 5 5 0 Basic region leucine zipper FUSC PF04632.12 CDW59133.1 - 0.033 12.8 4.5 0.047 12.2 4.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Sec34 PF04136.15 CDW59133.1 - 0.066 13.1 20.6 1.3 8.9 6.2 3.4 1 1 1 3 3 3 0 Sec34-like family Mce4_CUP1 PF11887.8 CDW59133.1 - 0.068 12.6 1.4 1.8 8.0 0.3 2.2 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF16 PF01519.16 CDW59133.1 - 0.12 12.8 18.3 1.1 9.8 1.6 3.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Noelin-1 PF12308.8 CDW59133.1 - 0.13 12.3 12.9 0.26 11.3 0.6 3.5 1 1 2 3 3 3 0 Neurogenesis glycoprotein YabA PF06156.13 CDW59133.1 - 0.16 12.6 18.9 5.3 7.7 6.7 3.6 1 1 1 2 2 2 0 Initiation control protein YabA APG6_N PF17675.1 CDW59133.1 - 0.29 11.7 28.4 1.5 9.3 0.9 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region Spc7 PF08317.11 CDW59133.1 - 0.38 9.6 28.3 1.6 7.5 12.4 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein KASH_CCD PF14662.6 CDW59133.1 - 0.41 10.4 28.1 2.5 7.9 12.0 3.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH SHE3 PF17078.5 CDW59133.1 - 0.56 9.9 24.6 0.43 10.3 5.8 3.6 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 DUF4407 PF14362.6 CDW59133.1 - 0.84 8.9 19.0 0.054 12.9 4.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 CDW59133.1 - 1.1 9.3 25.2 0.047 13.8 5.5 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF2203 PF09969.9 CDW59133.1 - 1.2 9.9 13.6 3.4 8.4 4.0 3.0 1 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) CENP-F_leu_zip PF10473.9 CDW59133.1 - 1.2 9.1 31.1 10 6.2 4.5 3.6 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 CDW59133.1 - 1.6 8.0 22.0 1.5 8.1 5.5 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF3450) kleA_kleC PF17383.2 CDW59133.1 - 1.6 9.1 8.3 2.2 8.7 0.8 3.1 3 1 0 3 3 2 0 Uncharacterized KorC regulated protein A TolA_bind_tri PF16331.5 CDW59133.1 - 2 8.5 10.7 0.82 9.8 0.9 3.5 2 1 1 3 3 3 0 TolA binding protein trimerisation MCC-bdg_PDZ PF10506.9 CDW59133.1 - 2.7 8.1 9.8 1.9 8.6 1.1 3.5 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome BLOC1_2 PF10046.9 CDW59133.1 - 2.9 8.3 21.9 6.2 7.2 3.7 4.1 1 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Cep57_CLD_2 PF14197.6 CDW59133.1 - 5.2 7.2 23.0 3.1 8.0 0.4 4.6 2 1 2 4 4 4 0 Centrosome localisation domain of PPC89 LXG PF04740.12 CDW59133.1 - 5.3 6.7 18.2 0.88 9.2 8.4 2.8 1 1 1 2 2 2 0 LXG domain of WXG superfamily Fez1 PF06818.15 CDW59133.1 - 5.7 7.3 25.1 3 8.3 9.7 2.4 1 1 1 2 2 2 0 Fez1 Glutaminase PF04960.15 CDW59134.1 - 0.062 12.5 0.2 0.83 8.8 0.0 2.3 1 1 0 2 2 2 0 Glutaminase DUF1600 PF07667.11 CDW59134.1 - 0.14 12.3 1.7 0.58 10.4 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1600) EGF PF00008.27 CDW59135.1 - 1.5e-10 41.1 20.5 1.7e-05 25.0 7.4 2.7 2 0 0 2 2 2 2 EGF-like domain EGF_2 PF07974.13 CDW59135.1 - 5.7e-07 29.8 26.6 0.00011 22.4 8.3 2.4 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 CDW59135.1 - 7.2e-06 26.4 17.4 0.0023 18.5 4.5 3.3 3 0 0 3 3 3 2 Human growth factor-like EGF Cadherin_C_2 PF16492.5 CDW59135.1 - 0.068 13.9 0.1 0.13 13.0 0.1 1.6 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Sigma_reg_N PF13800.6 CDW59135.1 - 0.15 12.4 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Laminin_EGF PF00053.24 CDW59135.1 - 0.48 10.6 19.5 18 5.5 5.6 2.4 1 1 1 2 2 2 0 Laminin EGF domain DSL PF01414.19 CDW59135.1 - 0.49 10.7 14.6 1.3 9.4 14.7 1.7 1 1 0 1 1 1 0 Delta serrate ligand EGF_3 PF12947.7 CDW59135.1 - 0.93 9.7 22.1 1.5 9.1 5.6 2.6 2 0 0 2 2 2 0 EGF domain FXa_inhibition PF14670.6 CDW59135.1 - 1.5 9.1 17.2 16 5.9 5.8 2.7 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW59135.1 - 5.3 7.1 16.2 0.34 10.9 2.0 3.0 2 1 0 2 2 2 0 Complement Clr-like EGF-like DSPc PF00782.20 CDW59136.1 - 3.4e-09 36.6 0.0 4.4e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 CDW59136.1 - 0.0039 17.3 0.0 0.0054 16.9 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPn PF14671.6 CDW59136.1 - 0.013 16.0 0.0 0.021 15.3 0.0 1.3 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Y_phosphatase PF00102.27 CDW59136.1 - 0.083 12.4 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase WD40 PF00400.32 CDW59137.1 - 2.8e-37 126.1 24.1 2.3e-08 34.5 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW59137.1 - 3.9e-13 49.5 0.4 0.078 13.3 0.0 5.4 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW59137.1 - 9.3e-08 31.7 0.1 0.026 13.9 0.0 3.9 3 1 2 5 5 5 3 WD40-like domain Ge1_WD40 PF16529.5 CDW59137.1 - 1.2e-05 24.4 0.2 1.1 8.1 0.1 3.2 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CDW59137.1 - 0.076 11.5 0.0 0.48 8.9 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain Med17 PF10156.9 CDW59137.1 - 0.2 10.3 0.2 0.26 9.9 0.2 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex Peptidase_C1 PF00112.23 CDW59138.1 - 2.6e-54 184.6 8.4 2.3e-26 93.3 5.5 2.1 2 0 0 2 2 2 2 Papain family cysteine protease Propeptide_C1 PF08127.13 CDW59138.1 - 0.024 14.5 0.1 0.044 13.7 0.1 1.4 1 0 0 1 1 1 0 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 CDW59138.1 - 0.23 10.2 0.6 3.1 6.5 0.1 2.1 2 0 0 2 2 2 0 Peptidase C1-like family KH_5 PF13184.6 CDW59139.1 - 5.6e-30 103.2 0.4 9.7e-28 96.1 0.2 2.4 2 0 0 2 2 2 1 NusA-like KH domain HHH_5 PF14520.6 CDW59139.1 - 9.4e-15 55.0 4.0 1.1e-09 38.7 0.4 3.2 4 0 0 4 4 4 2 Helix-hairpin-helix domain KH_2 PF07650.17 CDW59139.1 - 0.0011 18.7 0.1 0.016 15.0 0.0 2.5 2 1 0 2 2 2 1 KH domain DUF4332 PF14229.6 CDW59139.1 - 0.0031 17.8 0.1 1.2 9.3 0.1 2.6 1 1 0 2 2 2 2 Domain of unknown function (DUF4332) DNA_pol_lambd_f PF10391.9 CDW59139.1 - 0.013 15.3 0.0 1.9 8.4 0.0 3.3 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda KH_4 PF13083.6 CDW59139.1 - 0.047 13.6 0.1 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 KH domain RNA_pol_A_CTD PF03118.15 CDW59139.1 - 0.16 11.8 0.1 6 6.7 0.0 2.7 2 1 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain IF-2 PF11987.8 CDW59140.1 - 1.1e-36 125.2 2.0 4.1e-36 123.3 2.0 2.1 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU PF00009.27 CDW59140.1 - 4e-35 121.1 1.5 4e-35 121.1 1.5 3.2 2 2 0 2 2 1 1 Elongation factor Tu GTP binding domain IF2_N PF04760.15 CDW59140.1 - 7e-24 83.4 6.1 7.7e-15 54.5 1.2 2.8 2 0 0 2 2 2 2 Translation initiation factor IF-2, N-terminal region IF2_assoc PF08364.11 CDW59140.1 - 1.7e-16 60.1 4.6 7.5e-16 58.1 4.6 2.2 1 0 0 1 1 1 1 Bacterial translation initiation factor IF-2 associated region GTP_EFTU_D2 PF03144.25 CDW59140.1 - 3.9e-10 40.0 6.8 6.2e-07 29.7 0.7 4.0 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW59140.1 - 7.8e-10 38.8 0.1 2.7e-09 37.1 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CDW59140.1 - 1.2e-05 24.8 0.0 4.8e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.22 CDW59140.1 - 1.8e-05 24.4 0.0 1.8e-05 24.4 0.0 2.3 2 0 0 2 2 1 1 Ras family FeoB_N PF02421.18 CDW59140.1 - 7.9e-05 22.2 0.0 0.00021 20.8 0.0 1.8 1 0 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.9 CDW59140.1 - 0.00077 19.2 0.1 0.0034 17.1 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 CDW59140.1 - 0.001 18.1 0.4 0.001 18.1 0.4 3.8 3 1 1 4 4 4 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1_Xtn PF16897.5 CDW59140.1 - 0.0022 18.0 0.1 0.016 15.2 0.0 2.4 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain Roc PF08477.13 CDW59140.1 - 0.0028 17.8 0.0 0.0086 16.3 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CDW59140.1 - 0.0036 16.8 1.6 0.005 16.3 0.0 2.1 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit TruB_N PF01509.18 CDW59141.1 - 8.9e-58 194.9 0.0 1.2e-57 194.5 0.0 1.1 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CDW59141.1 - 4.4e-22 78.0 0.1 8.2e-22 77.1 0.1 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB-C_2 PF09157.11 CDW59141.1 - 9.5e-20 70.4 0.1 2.4e-19 69.1 0.1 1.7 1 0 0 1 1 1 1 Pseudouridine synthase II TruB, C-terminal Ribosomal_S15 PF00312.22 CDW59142.1 - 2.6e-38 130.1 1.5 2.9e-38 129.9 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S15 FliJ PF02050.16 CDW59142.1 - 0.027 14.7 0.3 0.031 14.5 0.3 1.0 1 0 0 1 1 1 0 Flagellar FliJ protein Stirrup PF09061.6 CDW59142.1 - 0.1 12.8 0.3 0.13 12.4 0.3 1.2 1 1 0 1 1 1 0 Stirrup RNase_PH PF01138.21 CDW59143.1 - 1.8e-42 144.9 0.0 9.7e-21 74.7 0.0 2.7 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 PNPase PF03726.14 CDW59143.1 - 4.7e-26 91.1 1.9 4.7e-26 91.1 1.9 2.3 2 0 0 2 2 2 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain S1 PF00575.23 CDW59143.1 - 2.6e-23 82.2 3.4 2.6e-23 82.2 3.4 2.6 2 0 0 2 2 2 1 S1 RNA binding domain RNase_PH_C PF03725.15 CDW59143.1 - 2.9e-21 75.3 5.4 5.9e-15 55.1 0.1 3.2 3 0 0 3 3 3 2 3' exoribonuclease family, domain 2 KH_1 PF00013.29 CDW59143.1 - 5.2e-09 35.8 3.4 5.2e-09 35.8 3.4 2.2 2 0 0 2 2 2 1 KH domain S1_2 PF13509.6 CDW59143.1 - 0.00051 20.0 0.6 0.0034 17.4 0.0 2.7 2 1 1 3 3 3 1 S1 domain KH_2 PF07650.17 CDW59143.1 - 0.0021 17.9 0.4 0.0021 17.9 0.4 2.9 3 0 0 3 3 3 1 KH domain DUF2110 PF09883.9 CDW59143.1 - 0.024 14.2 0.6 0.058 13.0 0.6 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) SLS PF14611.6 CDW59143.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator DEAD PF00270.29 CDW59144.1 - 2.2e-52 177.4 0.0 9.2e-52 175.3 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW59144.1 - 1.4e-31 109.1 0.0 2.3e-29 102.0 0.1 2.9 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW59144.1 - 2.1e-05 24.6 0.0 3.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CDW59144.1 - 0.0029 17.0 0.0 0.0051 16.2 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.6 CDW59144.1 - 0.0069 16.1 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain FAD_binding_9 PF08021.11 CDW59144.1 - 0.1 12.8 0.0 15 5.8 0.0 2.4 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain AAA_22 PF13401.6 CDW59144.1 - 0.11 12.8 0.4 0.88 9.8 0.1 2.6 2 1 0 2 2 2 0 AAA domain DRTGG PF07085.12 CDW59144.1 - 0.11 12.3 0.0 0.42 10.4 0.0 1.9 2 0 0 2 2 2 0 DRTGG domain UTP25 PF06862.12 CDW59144.1 - 0.18 10.5 0.0 0.42 9.3 0.0 1.5 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Bac_luciferase PF00296.20 CDW59145.1 - 1.3e-35 123.4 0.2 1.4e-34 119.9 0.2 1.9 1 1 0 1 1 1 1 Luciferase-like monooxygenase Peptidase_U32 PF01136.19 CDW59146.1 - 1.5e-77 259.9 0.1 1.4e-64 217.4 0.0 2.1 2 0 0 2 2 2 2 Peptidase family U32 Acetyltransf_7 PF13508.7 CDW59147.1 - 5.8e-11 42.7 0.0 8.5e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDW59147.1 - 3.2e-09 37.0 0.0 4.4e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CDW59147.1 - 5.7e-08 32.9 0.0 8.3e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDW59147.1 - 0.0002 21.3 0.0 0.00036 20.5 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDW59147.1 - 0.00028 20.9 0.0 0.00052 20.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CDW59147.1 - 0.021 14.8 0.1 0.071 13.1 0.0 1.9 2 1 0 2 2 2 0 FR47-like protein Acetyltransf_15 PF17013.5 CDW59147.1 - 0.022 14.2 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_3 PF13302.7 CDW59147.1 - 0.092 13.4 0.0 0.22 12.2 0.0 1.6 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain DJ-1_PfpI PF01965.24 CDW59148.1 - 7.5e-56 188.5 0.0 8.3e-56 188.3 0.0 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 CDW59148.1 - 0.0002 21.2 0.0 0.00022 21.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CDW59148.1 - 0.0025 17.6 0.0 0.0066 16.2 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 CDW59148.1 - 0.012 15.2 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 CDW59148.1 - 0.02 14.8 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family GATase_5 PF13507.6 CDW59148.1 - 0.18 10.8 0.0 0.35 9.9 0.0 1.6 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain NAD_binding_10 PF13460.6 CDW59149.1 - 1.6e-09 37.9 0.0 2.5e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 CDW59149.1 - 2.2e-06 28.1 0.0 7.5e-06 26.4 0.0 1.9 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain HIM1 PF08732.10 CDW59149.1 - 2.4e-06 27.2 0.0 3.3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 HIM1 Epimerase PF01370.21 CDW59149.1 - 1e-05 25.1 0.0 2.9e-05 23.6 0.0 1.9 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CDW59149.1 - 0.00033 19.9 0.0 0.13 11.5 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein DapB_N PF01113.20 CDW59149.1 - 0.042 14.0 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 CDW59149.1 - 0.051 12.7 0.0 1.9 7.5 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain F420H2_quin_red PF04075.14 CDW59149.1 - 0.098 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 F420H(2)-dependent quinone reductase ArsP_1 PF03773.13 CDW59150.1 - 3.4e-29 101.9 16.9 3e-18 66.0 7.7 1.9 1 1 1 2 2 2 2 Predicted permease PEMT PF04191.13 CDW59150.1 - 2.2 8.7 5.9 0.56 10.6 0.4 2.5 2 1 1 3 3 3 0 Phospholipid methyltransferase LppC PF04348.13 CDW59151.1 - 7.4e-123 411.2 23.2 2e-73 248.1 0.1 2.2 1 1 1 2 2 2 2 LppC putative lipoprotein SIS_2 PF13580.6 CDW59151.1 - 3.2e-28 98.5 1.1 1.2e-27 96.6 0.4 2.2 2 0 0 2 2 2 1 SIS domain BON PF04972.17 CDW59151.1 - 1.3e-26 92.7 5.7 4.7e-13 49.3 1.1 2.8 2 0 0 2 2 2 2 BON domain UPF0102 PF02021.17 CDW59151.1 - 1.1e-07 32.0 0.1 7.5e-07 29.3 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family UPF0102 SIS PF01380.22 CDW59151.1 - 3.4e-05 23.7 0.4 0.00048 20.0 0.0 2.8 3 0 0 3 3 3 1 SIS domain TPR_19 PF14559.6 CDW59151.1 - 0.032 14.7 1.0 0.032 14.7 1.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF3107 PF11305.8 CDW59151.1 - 0.17 12.1 0.2 0.79 10.0 0.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3107) TP_methylase PF00590.20 CDW59152.1 - 1e-29 104.0 0.2 1.7e-29 103.3 0.2 1.3 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Usher PF00577.20 CDW59153.1 - 1.3e-54 186.0 0.5 1.3e-54 186.0 0.5 1.5 2 0 0 2 2 2 1 Outer membrane usher protein Fimbrial PF00419.20 CDW59153.1 - 8.1e-23 81.4 0.1 8.1e-23 81.4 0.1 2.4 3 1 0 3 3 3 1 Fimbrial protein PapC_C PF13953.6 CDW59153.1 - 1.1e-10 41.2 0.0 2.9e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 PapC C-terminal domain ShlB PF03865.13 CDW59153.1 - 0.19 11.2 5.4 0.05 13.1 1.5 2.0 2 0 0 2 2 2 0 Haemolysin secretion/activation protein ShlB/FhaC/HecB HCO3_cotransp PF00955.21 CDW59154.1 - 5.6e-48 164.0 0.9 8.6e-48 163.4 0.9 1.2 1 0 0 1 1 1 1 HCO3- transporter family Vps36-NZF-N PF16988.5 CDW59154.1 - 0.16 11.4 0.2 0.3 10.5 0.2 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain ThrE PF06738.12 CDW59154.1 - 0.18 11.1 3.1 0.25 10.7 0.7 2.0 2 0 0 2 2 2 0 Putative threonine/serine exporter Na_Ca_ex PF01699.24 CDW59154.1 - 0.25 11.3 4.8 0.13 12.3 1.8 1.9 1 1 1 2 2 2 0 Sodium/calcium exchanger protein DUF1232 PF06803.12 CDW59159.1 - 8.3e-10 38.3 8.5 8.3e-10 38.3 8.5 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1232) zf-C3HC4_3 PF13920.6 CDW59159.1 - 6.8e-07 29.0 7.6 1.1e-06 28.4 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW59159.1 - 4.6e-06 26.4 10.0 8e-06 25.6 10.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW59159.1 - 5.5e-05 23.1 6.8 5.5e-05 23.1 6.8 1.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CDW59159.1 - 6.7e-05 22.6 11.6 0.00013 21.8 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CDW59159.1 - 7.9e-05 22.7 10.3 0.00014 22.0 10.3 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CDW59159.1 - 0.00013 22.2 11.6 0.00022 21.5 11.6 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 CDW59159.1 - 0.00028 20.7 10.1 0.00051 19.8 10.1 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CDW59159.1 - 0.00039 20.3 9.8 0.00083 19.3 9.8 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 CDW59159.1 - 0.076 13.3 7.8 0.17 12.2 7.8 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDW59159.1 - 0.26 11.3 5.1 0.9 9.6 5.2 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 CDW59159.1 - 7.3 6.8 10.3 18 5.6 10.3 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 Pkinase PF00069.25 CDW59160.1 - 1.1e-59 202.0 0.0 1.6e-59 201.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59160.1 - 6.7e-35 120.6 0.0 9.7e-35 120.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 CDW59160.1 - 1.3e-15 57.0 7.5 2.7e-15 56.0 7.5 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 CDW59160.1 - 7.4e-11 42.6 4.7 1.7e-10 41.4 4.7 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CDW59160.1 - 0.011 14.7 0.6 0.032 13.2 0.0 1.8 2 0 0 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 CDW59160.1 - 0.02 14.2 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 CDW59160.1 - 0.063 13.2 0.3 0.28 11.1 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW59160.1 - 0.18 10.5 0.0 0.76 8.5 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase ST7 PF04184.12 CDW59161.1 - 1.6e-178 594.5 22.4 5.6e-175 582.9 10.2 2.8 1 1 1 2 2 2 2 ST7 protein TPR_14 PF13428.6 CDW59161.1 - 1e-06 29.0 3.8 0.28 12.1 0.0 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW59161.1 - 1.2e-06 28.2 0.8 0.045 13.9 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW59161.1 - 1.4e-05 25.4 2.5 0.0001 22.7 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW59161.1 - 3.7e-05 24.1 5.1 0.037 14.5 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDW59161.1 - 0.00085 19.0 4.3 4.7 7.2 0.1 5.4 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDW59161.1 - 0.0041 17.7 0.4 0.43 11.3 0.0 3.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW59161.1 - 0.018 15.2 0.0 17 6.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDW59161.1 - 0.039 14.3 5.2 0.63 10.4 0.3 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.20 CDW59161.1 - 0.044 13.7 1.0 0.094 12.6 0.1 2.0 2 0 0 2 2 2 0 Region in Clathrin and VPS zf-met PF12874.7 CDW59162.1 - 1.2e-14 54.2 22.4 3.3e-05 24.1 1.0 4.4 4 0 0 4 4 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW59162.1 - 1.2e-12 47.8 19.4 1.7e-05 24.9 1.1 4.2 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CDW59162.1 - 0.0014 18.9 18.7 0.037 14.3 0.0 3.9 5 0 0 5 5 5 2 C2H2 type zinc-finger (2 copies) Triabin PF03973.13 CDW59162.1 - 0.024 14.5 0.1 0.05 13.5 0.1 1.6 1 0 0 1 1 1 0 Triabin zf-C2H2_4 PF13894.6 CDW59162.1 - 1.6 9.8 21.2 0.73 10.8 1.0 5.0 4 0 0 4 4 4 0 C2H2-type zinc finger S4 PF01479.25 CDW59163.1 - 0.0031 17.2 0.3 14 5.4 0.0 4.7 4 0 0 4 4 4 1 S4 domain Spp-24 PF07448.11 CDW59163.1 - 0.021 15.0 52.7 1.7 8.9 0.1 16.0 17 0 0 17 17 17 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain DUF3271 PF11675.8 CDW59163.1 - 1.8 7.8 11.0 3.6 6.8 0.2 4.9 7 0 0 7 7 7 0 Protein of unknown function (DUF3271) DUF2810 PF10928.8 CDW59163.1 - 3 7.9 5.2 9.9 6.3 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2810) LLGL PF08366.13 CDW59164.1 - 3.3e-19 69.2 0.0 7.8e-19 67.9 0.0 1.7 1 0 0 1 1 1 1 LLGL2 WD40 PF00400.32 CDW59164.1 - 3.3e-05 24.5 0.3 0.18 12.7 0.0 3.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Hira PF07569.11 CDW59164.1 - 0.04 13.6 0.6 5.4 6.7 0.1 2.3 2 0 0 2 2 2 0 TUP1-like enhancer of split Thioredoxin PF00085.20 CDW59165.1 - 8.7e-08 32.1 0.0 1.8e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 CDW59165.1 - 0.00013 21.1 0.1 0.00016 20.7 0.1 1.1 1 0 0 1 1 1 1 Phosducin C1_1 PF00130.22 CDW59165.1 - 0.053 13.4 0.5 0.098 12.6 0.5 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) BssS PF13991.6 CDW59165.1 - 0.14 12.2 0.1 0.27 11.3 0.1 1.5 1 0 0 1 1 1 0 BssS protein family ANAPC4_WD40 PF12894.7 CDW59166.1 - 7.4e-10 39.0 0.0 0.08 13.3 0.0 4.2 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDW59166.1 - 5.2e-08 33.4 0.8 0.16 12.9 0.1 4.1 3 1 0 3 3 3 3 WD domain, G-beta repeat Hira PF07569.11 CDW59166.1 - 0.063 13.0 0.0 0.53 10.0 0.0 2.1 2 0 0 2 2 2 0 TUP1-like enhancer of split MFS_1 PF07690.16 CDW59167.1 - 3.6e-45 154.4 43.6 1.8e-44 152.1 35.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Shisa PF13908.6 CDW59168.1 - 0.0045 17.3 0.8 0.01 16.1 0.8 1.6 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator SIT PF15330.6 CDW59168.1 - 0.016 15.6 0.4 0.016 15.6 0.4 2.3 3 1 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT Neur_chan_memb PF02932.16 CDW59168.1 - 0.086 12.9 3.7 0.14 12.2 3.7 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EphA2_TM PF14575.6 CDW59168.1 - 0.16 12.9 1.0 0.55 11.2 1.0 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain R_equi_Vir PF05526.11 CDW59168.1 - 0.38 10.6 3.8 0.12 12.2 0.3 1.9 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein TMEM154 PF15102.6 CDW59168.1 - 0.38 10.6 0.0 0.38 10.6 0.0 3.6 2 1 1 3 3 3 0 TMEM154 protein family MAP17 PF15807.5 CDW59168.1 - 1 9.6 6.7 0.71 10.1 0.3 2.6 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF2012 PF09430.10 CDW59169.1 - 2.7e-25 88.9 0.0 4e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) SH2 PF00017.24 CDW59170.1 - 1.3e-05 25.2 0.1 0.41 10.8 0.0 4.3 4 0 0 4 4 4 3 SH2 domain Glyco_hydro_20 PF00728.22 CDW59171.1 - 5.3e-15 55.7 0.0 7.4e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain DUF4838 PF16126.5 CDW59171.1 - 9.5e-07 28.4 0.1 1.6e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4838) F-box-like PF12937.7 CDW59172.1 - 2.5e-16 59.3 0.2 2.5e-16 59.3 0.2 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 CDW59172.1 - 1.1e-11 44.3 4.0 1.3e-10 40.9 0.1 3.3 3 0 0 3 3 3 1 F-box domain F-box_4 PF15966.5 CDW59172.1 - 0.0045 16.8 0.1 3.9 7.4 0.0 2.6 2 0 0 2 2 2 2 F-box Methyltransf_12 PF08242.12 CDW59172.1 - 0.069 13.9 0.0 45 4.9 0.0 3.4 3 0 0 3 3 3 0 Methyltransferase domain LRR_4 PF12799.7 CDW59172.1 - 0.11 13.0 15.8 0.8 10.2 0.1 6.6 5 2 4 9 9 9 0 Leucine Rich repeats (2 copies) Metallophos PF00149.28 CDW59173.1 - 5e-31 108.8 0.1 6.4e-31 108.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ABC_membrane PF00664.23 CDW59174.1 - 3.8e-35 121.9 11.2 5.6e-35 121.3 11.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CDW59174.1 - 6.2e-10 39.7 0.0 1.2e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CDW59174.1 - 0.0033 16.9 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Bromodomain PF00439.25 CDW59176.1 - 2.4e-12 46.7 0.0 1.4e-11 44.3 0.0 2.1 2 0 0 2 2 2 1 Bromodomain zf-C2H2_4 PF13894.6 CDW59177.1 - 6.6e-05 23.4 10.6 0.085 13.7 5.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW59177.1 - 0.00018 21.8 12.9 0.22 12.1 8.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CDW59177.1 - 0.0011 19.2 12.4 0.25 11.7 10.6 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW59177.1 - 0.0023 18.2 10.2 0.18 12.2 10.6 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDW59177.1 - 0.013 15.8 11.5 0.019 15.3 7.3 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_aberr PF17017.5 CDW59177.1 - 0.065 13.4 6.3 0.19 11.9 0.5 2.2 2 0 0 2 2 2 0 Aberrant zinc-finger UBX PF00789.20 CDW59178.1 - 3.3e-14 52.8 0.0 8.3e-14 51.5 0.0 1.7 1 0 0 1 1 1 1 UBX domain Pkinase PF00069.25 CDW59179.1 - 1.9e-48 165.1 0.0 4.9e-32 111.3 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59179.1 - 7e-17 61.6 0.3 6.1e-08 32.3 0.0 2.9 3 1 0 3 3 3 2 Protein tyrosine kinase zf-SNAP50_C PF12251.8 CDW59180.1 - 1e-61 208.1 0.4 1.4e-61 207.7 0.4 1.2 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal zf-RING_7 PF02591.15 CDW59180.1 - 0.14 12.3 1.5 11 6.3 0.0 3.7 4 0 0 4 4 4 0 C4-type zinc ribbon domain BAF PF02961.14 CDW59182.1 - 1.5e-33 115.1 0.1 1.6e-33 115.0 0.1 1.0 1 0 0 1 1 1 1 Barrier to autointegration factor ANAPC3 PF12895.7 CDW59182.1 - 0.022 15.0 0.1 0.026 14.8 0.1 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 HHH_5 PF14520.6 CDW59182.1 - 0.03 14.9 0.0 0.048 14.3 0.0 1.5 1 1 0 1 1 1 0 Helix-hairpin-helix domain HHH_8 PF14716.6 CDW59182.1 - 0.072 13.5 0.0 0.23 11.9 0.0 1.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain Nuc_sug_transp PF04142.15 CDW59183.1 - 3.4e-110 368.1 23.8 4.1e-110 367.8 23.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 CDW59183.1 - 0.00037 20.7 8.2 0.00037 20.7 8.2 2.5 2 1 0 2 2 2 1 EamA-like transporter family EmrE PF13536.6 CDW59183.1 - 0.02 14.5 16.3 0.025 14.2 15.1 2.0 1 1 0 1 1 1 0 Putative multidrug resistance efflux transporter CLPTM1 PF05602.12 CDW59184.1 - 1.3e-99 334.2 0.1 1.5e-99 334.0 0.1 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PKcGMP_CC PF16808.5 CDW59186.1 - 0.00051 19.8 4.1 0.00054 19.7 1.3 2.6 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase protein_MS5 PF04776.12 CDW59186.1 - 0.015 15.4 0.5 0.042 13.9 0.5 1.8 1 0 0 1 1 1 0 Protein MS5 DUF2381 PF09544.10 CDW59186.1 - 0.028 14.0 4.7 1.7 8.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) DUF3138 PF11336.8 CDW59186.1 - 0.082 11.5 0.9 0.1 11.2 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) CENP-F_leu_zip PF10473.9 CDW59186.1 - 0.26 11.3 25.1 2 8.4 4.8 3.1 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 CDW59186.1 - 0.62 10.5 22.6 0.26 11.7 10.7 2.2 1 1 1 2 2 2 0 Fez1 SlyX PF04102.12 CDW59186.1 - 0.7 10.5 10.9 0.81 10.4 7.9 2.6 1 1 0 2 2 2 0 SlyX FlgN PF05130.12 CDW59186.1 - 1.9 9.0 16.6 0.12 12.8 10.3 2.0 2 0 0 2 2 2 0 FlgN protein YabA PF06156.13 CDW59186.1 - 2.8 8.6 22.5 0.57 10.9 2.5 3.6 2 2 1 3 3 3 0 Initiation control protein YabA HAUS-augmin3 PF14932.6 CDW59186.1 - 3.7 7.1 19.7 0.34 10.4 13.0 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF2203 PF09969.9 CDW59186.1 - 5.1 7.8 13.8 10 6.9 6.6 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF3450 PF11932.8 CDW59186.1 - 5.5 6.2 17.5 3.7 6.8 11.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF641 PF04859.12 CDW59186.1 - 8.7 6.7 23.5 0.1 12.9 5.3 3.7 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) COX5A PF02284.16 CDW59187.1 - 1.2e-42 144.1 0.0 1.5e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Reprolysin PF01421.19 CDW59188.1 - 5e-34 118.0 0.0 8e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 CDW59188.1 - 2e-22 79.8 3.6 2e-22 79.8 3.6 3.0 3 1 0 3 3 3 1 ADAM cysteine-rich Pep_M12B_propep PF01562.19 CDW59188.1 - 6.7e-20 71.7 0.1 1.3e-19 70.8 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Disintegrin PF00200.23 CDW59188.1 - 3.8e-19 69.3 27.1 3.8e-19 69.3 27.1 2.7 3 0 0 3 3 3 1 Disintegrin Reprolysin_5 PF13688.6 CDW59188.1 - 7.2e-05 23.0 0.0 0.00014 22.1 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CDW59188.1 - 0.00071 19.3 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CDW59188.1 - 0.0038 17.1 0.0 0.0062 16.5 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CDW59188.1 - 0.004 17.7 0.0 0.0075 16.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 CDW59188.1 - 0.089 12.6 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Matrixin UPF0449 PF15136.6 CDW59189.1 - 0.0001 22.7 0.2 0.00018 21.9 0.2 1.5 1 1 0 1 1 1 1 Uncharacterised protein family UPF0449 RNA_pol_N PF01194.17 CDW59190.1 - 4e-34 116.7 0.2 4.5e-34 116.5 0.2 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 CDW59190.1 - 0.031 14.5 0.2 0.046 14.0 0.2 1.3 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Ribosomal_L7Ae PF01248.26 CDW59191.1 - 7.1e-26 89.8 0.8 9.3e-26 89.4 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SID-1_RNA_chan PF13965.6 CDW59192.1 - 5.8e-187 622.8 31.7 9.5e-186 618.8 31.7 1.9 1 1 0 1 1 1 1 dsRNA-gated channel SID-1 Ceramidase PF05875.12 CDW59192.1 - 0.17 11.3 22.1 0.067 12.6 15.8 2.5 2 1 0 2 2 2 0 Ceramidase UPF0542 PF15086.6 CDW59192.1 - 0.34 10.9 3.1 7 6.7 0.2 3.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 DUF669 PF05037.13 CDW59194.1 - 0.019 15.1 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF669) RPN1_RPN2_N PF17781.1 CDW59194.1 - 0.03 13.7 0.0 0.06 12.7 0.0 1.3 1 1 0 1 1 1 0 RPN1/RPN2 N-terminal domain PKD_channel PF08016.12 CDW59196.1 - 8.3e-11 41.2 16.5 1.7e-10 40.2 16.5 1.5 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 CDW59196.1 - 8.8e-08 31.7 19.5 1.6e-07 30.8 19.5 1.4 1 0 0 1 1 1 1 Ion transport protein CactinC_cactus PF09732.9 CDW59196.1 - 0.087 12.8 0.2 0.2 11.6 0.2 1.6 1 0 0 1 1 1 0 Cactus-binding C-terminus of cactin protein SRTM1 PF15872.5 CDW59196.1 - 0.36 11.0 2.7 5.5 7.2 1.3 2.6 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 FH2 PF02181.23 CDW59197.1 - 2.9e-27 95.7 3.5 2.9e-27 95.7 3.5 1.4 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_DAD PF06345.11 CDW59197.1 - 2.1e-07 30.5 1.1 4.2e-07 29.5 1.1 1.5 1 0 0 1 1 1 1 DRF Autoregulatory Domain Act-Frag_cataly PF09192.10 CDW59197.1 - 0.064 12.6 3.3 0.051 13.0 1.3 1.7 1 1 1 2 2 2 0 Actin-fragmin kinase, catalytic PfkB PF00294.24 CDW59198.1 - 5.1e-58 196.7 0.3 6.2e-58 196.5 0.3 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CDW59198.1 - 9.1e-10 38.3 0.1 1.3e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase MMS19_N PF14500.6 CDW59199.1 - 5.3e-43 147.5 5.5 2.1e-41 142.2 1.1 2.5 2 0 0 2 2 2 2 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 CDW59199.1 - 3.4e-05 23.1 3.0 4.1e-05 22.9 0.1 2.6 2 1 0 2 2 2 1 RNAPII transcription regulator C-terminal HEAT_2 PF13646.6 CDW59199.1 - 0.007 16.7 0.2 1.7 9.1 0.0 3.9 4 0 0 4 4 4 1 HEAT repeats DUF3916 PF13079.6 CDW59199.1 - 0.036 14.0 0.1 0.081 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3916) HEAT PF02985.22 CDW59199.1 - 0.13 12.6 0.8 24 5.5 0.1 4.2 4 0 0 4 4 4 0 HEAT repeat Sec7_N PF12783.7 CDW59199.1 - 3 7.7 9.4 1.7 8.5 0.7 3.6 2 1 1 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal ATP-synt_F PF01990.17 CDW59200.1 - 8.8e-30 102.9 0.1 1e-29 102.7 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF5588 PF17826.1 CDW59200.1 - 0.038 12.9 0.0 0.046 12.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5588) PGM_PMM_I PF02878.16 CDW59202.1 - 2.8e-23 82.2 0.1 3.5e-23 81.8 0.1 1.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I UCR_hinge PF02320.16 CDW59204.1 - 3.2e-19 68.9 5.7 3.7e-19 68.7 5.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein MTCP1 PF08991.10 CDW59204.1 - 0.047 13.9 4.0 0.7 10.2 0.2 2.1 1 1 1 2 2 2 0 Mature-T-Cell Proliferation I type DUF2753 PF10952.8 CDW59204.1 - 0.061 13.5 0.9 0.076 13.1 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2753) Cmc1 PF08583.10 CDW59204.1 - 0.24 11.4 5.9 2.1 8.4 5.9 2.0 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 CDW59204.1 - 0.26 11.5 3.1 4.2 7.6 0.1 2.8 2 1 1 3 3 3 0 CHCH domain Vma12 PF11712.8 CDW59205.1 - 1.2e-25 90.2 0.1 1.6e-25 89.8 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase TIP49 PF06068.13 CDW59206.1 - 1.9e-129 431.9 2.8 2.5e-129 431.5 2.8 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDW59206.1 - 8.1e-17 61.1 0.8 3e-16 59.3 0.3 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 CDW59206.1 - 9.5e-11 42.2 1.0 1.5e-06 28.6 0.2 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDW59206.1 - 4.8e-07 29.6 0.4 0.00057 19.7 0.1 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDW59206.1 - 1.4e-05 25.5 0.0 5.8e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 CDW59206.1 - 1.9e-05 24.7 0.0 0.0087 16.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDW59206.1 - 2e-05 24.1 0.7 0.0011 18.4 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDW59206.1 - 3.9e-05 23.4 0.2 0.056 13.2 0.3 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_19 PF13245.6 CDW59206.1 - 4.5e-05 23.8 0.8 0.0013 19.1 0.8 2.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW59206.1 - 0.00014 22.1 0.1 0.51 10.6 0.0 2.7 2 1 0 3 3 2 2 AAA domain AAA_7 PF12775.7 CDW59206.1 - 0.00079 19.0 0.0 0.017 14.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region DnaB_C PF03796.15 CDW59206.1 - 0.00091 18.6 0.1 0.0024 17.2 0.0 1.8 1 1 1 2 2 2 1 DnaB-like helicase C terminal domain AAA_25 PF13481.6 CDW59206.1 - 0.0011 18.6 0.3 0.003 17.2 0.2 1.7 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 CDW59206.1 - 0.0025 17.2 1.4 0.0062 15.9 0.6 2.0 2 1 0 2 2 2 1 KaiC AAA_33 PF13671.6 CDW59206.1 - 0.0039 17.3 0.0 0.011 15.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain Sigma54_activ_2 PF14532.6 CDW59206.1 - 0.0093 16.1 0.0 1.7 8.8 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain TsaE PF02367.17 CDW59206.1 - 0.02 14.9 0.1 0.058 13.4 0.1 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 CDW59206.1 - 0.027 13.7 0.1 0.062 12.6 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 CDW59206.1 - 0.03 14.0 0.4 1.7 8.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 CDW59206.1 - 0.035 13.9 0.1 0.072 12.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CDW59206.1 - 0.037 14.4 0.0 0.091 13.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 CDW59206.1 - 0.039 13.9 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DEAD PF00270.29 CDW59206.1 - 0.04 13.7 2.3 0.2 11.4 2.3 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase SRPRB PF09439.10 CDW59206.1 - 0.045 13.2 0.1 0.14 11.6 0.0 1.8 2 0 0 2 2 1 0 Signal recognition particle receptor beta subunit ResIII PF04851.15 CDW59206.1 - 0.062 13.3 0.1 5.4 7.0 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 CDW59206.1 - 0.083 13.4 0.2 0.81 10.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CDW59206.1 - 0.13 11.9 0.1 0.4 10.4 0.1 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 CDW59206.1 - 0.15 11.5 3.2 1 8.8 0.2 2.8 2 1 0 3 3 3 0 PhoH-like protein AAA_29 PF13555.6 CDW59206.1 - 0.17 11.7 0.3 2.1 8.2 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA PF00004.29 CDW59207.1 - 1.2e-39 135.8 0.0 2.3e-39 134.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW59207.1 - 1.6e-06 28.1 0.0 5e-06 26.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 CDW59207.1 - 2.5e-06 27.2 0.0 5.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 CDW59207.1 - 6e-05 23.0 0.0 0.00013 21.9 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 CDW59207.1 - 8.6e-05 22.3 0.0 0.00022 21.0 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 CDW59207.1 - 0.0013 18.4 0.1 0.0062 16.1 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW59207.1 - 0.003 17.9 0.4 0.23 11.9 0.1 2.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CDW59207.1 - 0.0033 17.7 1.1 0.55 10.5 0.2 2.5 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 CDW59207.1 - 0.0085 15.3 0.1 0.022 14.0 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain ATPase PF06745.13 CDW59207.1 - 0.023 14.1 0.8 3.2 7.0 0.2 2.4 1 1 1 2 2 2 0 KaiC Sigma54_activat PF00158.26 CDW59207.1 - 0.05 13.3 0.0 5 6.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 CDW59207.1 - 0.095 12.1 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CDW59207.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 CDW59207.1 - 0.14 12.3 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 CDW59207.1 - 0.15 11.5 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 CDW59207.1 - 0.19 12.0 0.0 0.42 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain OB_NTP_bind PF07717.16 CDW59208.1 - 3.7e-25 88.1 0.0 8.1e-25 87.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CDW59208.1 - 3.3e-24 85.2 5.7 4.3e-24 84.9 0.0 2.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDW59208.1 - 3.3e-14 53.2 0.0 4e-13 49.7 0.0 2.6 3 0 0 3 3 2 1 Helicase conserved C-terminal domain S1 PF00575.23 CDW59208.1 - 6.7e-10 39.2 0.2 1.4e-09 38.1 0.2 1.6 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 CDW59208.1 - 0.00044 20.5 0.0 0.0014 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CDW59208.1 - 0.0035 16.5 0.1 0.0094 15.0 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein DEAD PF00270.29 CDW59208.1 - 0.0048 16.7 0.3 0.027 14.3 0.3 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_16 PF13191.6 CDW59208.1 - 0.044 14.2 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain CDC45 PF02724.14 CDW59208.1 - 0.047 12.0 10.0 0.007 14.7 4.5 2.1 2 0 0 2 2 2 0 CDC45-like protein AAA_19 PF13245.6 CDW59208.1 - 0.069 13.5 0.0 0.19 12.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain PhoH PF02562.16 CDW59208.1 - 0.094 12.2 0.0 0.23 10.9 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 CDW59208.1 - 0.11 13.0 0.2 0.57 10.7 0.2 2.2 1 1 0 1 1 1 0 ABC transporter AAA_11 PF13086.6 CDW59208.1 - 4.6 7.0 9.0 10 5.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain Presenilin PF01080.17 CDW59208.1 - 6.3 5.5 5.4 12 4.5 5.4 1.4 1 0 0 1 1 1 0 Presenilin Peptidase_C65 PF10275.9 CDW59209.1 - 3.9e-19 69.1 0.0 4.9e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain Peptidase_C101 PF16218.5 CDW59209.1 - 0.012 14.9 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C101 RGS PF00615.19 CDW59211.1 - 1.6e-21 76.7 2.3 3e-21 75.9 2.3 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDZ PF00595.24 CDW59211.1 - 2e-09 37.6 0.0 4.7e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW59211.1 - 1.2e-08 34.6 0.6 3.4e-08 33.2 0.6 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW59211.1 - 0.0002 21.6 0.0 0.00048 20.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain REPA_OB_2 PF16900.5 CDW59212.1 - 5.1e-14 52.0 0.3 1.1e-13 50.9 0.2 1.6 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 CDW59212.1 - 3.5e-06 26.9 0.2 2.2e-05 24.4 0.1 2.3 2 1 0 2 2 2 1 OB-fold nucleic acid binding domain RabGAP-TBC PF00566.18 CDW59213.1 - 1.3e-26 93.6 8.0 1.6e-26 93.3 2.9 2.3 2 0 0 2 2 2 1 Rab-GTPase-TBC domain RUN PF02759.19 CDW59213.1 - 4.9e-24 84.8 0.0 2.3e-23 82.7 0.0 2.1 2 0 0 2 2 2 1 RUN domain PH_RBD PF12068.8 CDW59213.1 - 2.4e-12 46.7 0.0 4.9e-11 42.4 0.0 2.3 1 1 0 1 1 1 1 Rab-binding domain (RBD) FATC PF02260.20 CDW59213.1 - 0.065 13.1 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 FATC domain Coatomer_g_Cpla PF16381.5 CDW59214.1 - 0.18 11.9 0.8 0.79 9.9 0.1 2.3 2 0 0 2 2 2 0 Coatomer subunit gamma-1 C-terminal appendage platform Peptidase_M10 PF00413.24 CDW59215.1 - 5.1e-39 133.7 1.4 4.6e-38 130.6 0.1 3.0 3 1 0 3 3 3 1 Matrixin Hemopexin PF00045.19 CDW59215.1 - 3.3e-30 103.8 13.0 1.6e-12 47.2 2.0 3.7 4 0 0 4 4 4 3 Hemopexin PG_binding_1 PF01471.18 CDW59215.1 - 2e-06 27.9 0.0 4e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain YHS PF04945.13 CDW59215.1 - 0.16 12.1 0.3 0.56 10.4 0.1 1.9 2 0 0 2 2 2 0 YHS domain SH3_9 PF14604.6 CDW59216.1 - 1.5e-06 27.9 0.0 2.6e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW59216.1 - 0.0093 15.6 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain HLH PF00010.26 CDW59217.1 - 2.2e-13 49.9 2.8 3.9e-13 49.1 2.8 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PRKG1_interact PF15898.5 CDW59217.1 - 0.015 16.2 4.5 0.03 15.2 4.5 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 CDW59217.1 - 0.02 15.5 0.2 0.038 14.6 0.2 1.5 1 0 0 1 1 1 0 Initiation control protein YabA Fzo_mitofusin PF04799.13 CDW59217.1 - 0.21 11.1 1.3 0.33 10.5 1.3 1.3 1 0 0 1 1 1 0 fzo-like conserved region PHD PF00628.29 CDW59218.1 - 2e-24 85.2 50.2 9.2e-10 38.3 10.4 6.0 4 1 1 5 5 5 4 PHD-finger SET PF00856.28 CDW59218.1 - 2.3e-19 70.4 0.2 2.3e-19 70.4 0.2 3.0 2 1 0 2 2 2 1 SET domain FYRN PF05964.14 CDW59218.1 - 5.2e-19 67.8 0.7 1.2e-18 66.7 0.7 1.7 1 0 0 1 1 1 1 F/Y-rich N-terminus zf-HC5HC2H_2 PF13832.6 CDW59218.1 - 4.8e-13 49.2 5.5 4.8e-13 49.2 5.5 5.1 2 1 2 4 4 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CDW59218.1 - 2.8e-11 43.5 2.6 2.8e-11 43.5 2.6 5.6 2 1 3 5 5 4 1 PHD-like zinc-binding domain HMG_box_2 PF09011.10 CDW59218.1 - 0.0011 19.5 0.5 0.0035 17.9 0.5 1.8 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 CDW59218.1 - 0.0032 17.8 0.2 0.0095 16.3 0.2 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box FYRC PF05965.14 CDW59218.1 - 0.0061 16.7 0.2 0.066 13.4 0.0 2.9 3 0 0 3 3 2 1 F/Y rich C-terminus MIP-T3_C PF17749.1 CDW59218.1 - 0.0084 16.1 10.0 0.021 14.8 9.9 1.7 1 1 0 1 1 1 1 Microtubule-binding protein MIP-T3 C-terminal region FliJ PF02050.16 CDW59218.1 - 0.024 14.9 12.7 0.082 13.1 12.7 1.9 1 0 0 1 1 1 0 Flagellar FliJ protein Spc7 PF08317.11 CDW59218.1 - 0.03 13.2 10.1 0.051 12.5 10.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Phage_GPO PF05929.11 CDW59218.1 - 1.2 8.7 9.8 2.3 7.8 9.8 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Seryl_tRNA_N PF02403.22 CDW59218.1 - 2.8 8.2 8.6 7.9 6.8 8.6 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 CDW59218.1 - 3.2 7.0 9.6 5.2 6.3 9.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 CDW59218.1 - 3.7 6.1 7.4 22 3.5 8.5 1.6 1 1 1 2 2 2 0 Flagellar Assembly Protein A S4 PF01479.25 CDW59219.1 - 2.1e-06 27.3 0.7 2.5 7.9 0.0 6.9 7 0 0 7 7 7 2 S4 domain Cystatin PF00031.21 CDW59219.1 - 3.4e-06 27.2 39.0 0.037 14.3 0.1 12.2 14 0 0 14 14 14 4 Cystatin domain KIX PF02172.16 CDW59219.1 - 0.17 12.2 2.5 1.2e+02 3.0 0.0 4.5 4 0 0 4 4 4 0 KIX domain DUF3271 PF11675.8 CDW59219.1 - 0.5 9.6 12.3 5.6 6.1 0.3 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF3271) Spp-24 PF07448.11 CDW59219.1 - 0.93 9.7 48.1 3.1 8.0 0.2 14.2 16 0 0 16 16 16 0 Secreted phosphoprotein 24 (Spp-24) cystatin-like domain DSPc PF00782.20 CDW59220.1 - 2.2e-05 24.3 0.0 3.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.11 CDW59221.1 - 3.9e-15 55.5 5.1 6.9e-15 54.7 5.1 1.4 1 0 0 1 1 1 1 DEK C terminal domain DSPc PF00782.20 CDW59221.1 - 2.7e-05 24.0 0.2 0.0001 22.2 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Acatn PF13000.7 CDW59222.1 - 1.1e-100 337.8 22.4 3.3e-67 227.3 5.7 4.0 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 DUF809 PF05663.11 CDW59222.1 - 0.079 13.1 0.1 0.41 10.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF809) BTB PF00651.31 CDW59223.1 - 2.3e-09 37.4 1.0 5.5e-09 36.2 0.4 1.8 1 1 1 2 2 2 1 BTB/POZ domain TerB_C PF15615.6 CDW59224.1 - 0.0064 16.8 0.9 0.0064 16.8 0.9 2.5 2 1 1 3 3 3 1 TerB-C domain CCDC53 PF10152.9 CDW59224.1 - 0.014 15.9 4.4 0.79 10.1 3.9 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex OEP PF02321.18 CDW59224.1 - 0.019 14.8 6.8 0.041 13.7 6.8 1.6 1 0 0 1 1 1 0 Outer membrane efflux protein Spc7 PF08317.11 CDW59224.1 - 0.19 10.5 15.0 0.36 9.7 15.0 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Histone PF00125.24 CDW59225.1 - 2e-20 73.5 0.1 2.4e-20 73.2 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59225.1 - 1.2e-05 25.5 0.2 2.5e-05 24.5 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW59225.1 - 0.0058 16.7 0.2 0.0065 16.5 0.2 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 CDW59225.1 - 0.012 16.0 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 CDW59226.1 - 3.2e-72 241.0 5.0 2.1e-49 167.2 3.4 3.1 2 1 1 3 3 3 3 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59226.1 - 1.6e-14 54.0 0.1 0.00071 19.8 0.0 3.4 3 0 0 3 3 3 3 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 CDW59226.1 - 2.5e-12 46.9 1.0 1.3e-05 25.3 0.1 2.6 2 0 0 2 2 2 2 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 CDW59226.1 - 5.5e-10 39.4 0.2 0.00047 20.2 0.0 3.1 3 0 0 3 3 3 2 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 CDW59226.1 - 6.7e-10 39.2 0.3 0.0002 21.7 0.0 2.5 2 0 0 2 2 2 2 CENP-S protein Histone_H2A_C PF16211.5 CDW59226.1 - 4.8e-05 23.0 0.0 0.00013 21.6 0.0 1.7 1 0 0 1 1 1 1 C-terminus of histone H2A Bromo_TP PF07524.13 CDW59226.1 - 0.00018 21.5 0.8 0.25 11.4 0.1 2.5 2 0 0 2 2 2 2 Bromodomain associated PAF PF15715.5 CDW59226.1 - 0.00043 20.9 1.3 0.0007 20.2 1.3 1.3 1 0 0 1 1 1 1 PCNA-associated factor histone like domain TAF PF02969.17 CDW59226.1 - 0.0036 17.5 2.8 0.0097 16.1 0.1 2.8 3 1 0 3 3 3 1 TATA box binding protein associated factor (TAF) Ribosomal_S10 PF00338.22 CDW59228.1 - 3e-20 72.3 0.0 4.7e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e BRCT PF00533.26 CDW59229.1 - 9.9e-35 118.8 0.5 4.1e-13 49.5 0.0 4.9 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CDW59229.1 - 8.9e-18 64.0 0.1 3.5e-10 39.7 0.0 4.6 4 0 0 4 4 4 2 twin BRCT domain BRCT_2 PF16589.5 CDW59229.1 - 1.6e-12 47.6 0.0 0.0022 18.3 0.0 4.5 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 CDW59229.1 - 1.5e-09 37.7 0.0 2.5e-07 30.5 0.0 3.4 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 CDW59229.1 - 4.8e-06 26.6 0.0 1.1 9.4 0.0 4.3 4 0 0 4 4 4 2 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CDW59229.1 - 2.2e-05 24.6 0.1 12 6.3 0.0 4.3 4 0 0 4 4 4 3 DNA ligase 3 BRCT domain MEF2_binding PF09047.10 CDW59229.1 - 2.7 7.9 5.9 13 5.8 0.2 3.0 2 0 0 2 2 2 0 MEF2 binding IMS PF00817.20 CDW59231.1 - 3.6e-43 147.2 0.1 2e-42 144.7 0.0 2.2 2 1 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 CDW59231.1 - 6.1e-15 56.0 0.3 1.4e-14 54.8 0.3 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CDW59231.1 - 1.6e-05 25.0 0.0 3.8e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif zf-Nse PF11789.8 CDW59231.1 - 3.5 7.5 5.2 3.4 7.5 0.1 3.4 4 1 0 4 4 4 0 Zinc-finger of the MIZ type in Nse subunit DUF1899 PF08953.11 CDW59232.1 - 9.4e-29 99.1 0.1 1.6e-28 98.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 CDW59232.1 - 4.7e-06 27.2 0.1 0.0083 17.0 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Ribosomal_S19 PF00203.21 CDW59234.1 - 5.8e-35 119.0 0.1 1e-34 118.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S19 UPF0228 PF05727.11 CDW59235.1 - 0.0084 15.9 0.2 0.027 14.3 0.3 1.8 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0228) Ribosomal_S19 PF00203.21 CDW59237.1 - 6e-35 119.0 0.1 1e-34 118.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S19 DUF3915 PF13054.6 CDW59238.1 - 1.7 8.6 6.8 4.4 7.3 6.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Mito_carr PF00153.27 CDW59239.1 - 3.9e-06 26.7 0.1 4.8e-06 26.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein Ribosomal_S6 PF01250.17 CDW59241.1 - 4.2e-26 91.0 0.3 4.7e-26 90.9 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S6 AbiJ_NTD3 PF18860.1 CDW59241.1 - 0.015 14.8 0.2 0.28 10.7 0.0 2.0 1 1 1 2 2 2 0 AbiJ N-terminal domain 3 HAD_SAK_2 PF18143.1 CDW59241.1 - 0.021 15.1 0.1 0.022 15.1 0.1 1.1 1 0 0 1 1 1 0 HAD domain in Swiss Army Knife RNA repair proteins DNA_topoisoIV PF00521.20 CDW59242.1 - 3.1e-161 537.0 1.0 5.4e-161 536.2 1.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A DNA_gyraseA_C PF03989.13 CDW59242.1 - 1.3e-70 232.7 22.5 2.8e-12 45.9 0.2 6.7 6 0 0 6 6 6 6 DNA gyrase C-terminal domain, beta-propeller DNA_gyraseB PF00204.25 CDW59242.1 - 3.6e-65 218.7 0.9 1.1e-64 217.2 0.9 1.9 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 CDW59242.1 - 1.2e-24 86.3 0.2 3.3e-24 84.8 0.2 1.8 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CDW59242.1 - 8.5e-21 74.6 1.1 2.2e-20 73.2 0.3 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDW59242.1 - 5.6e-18 65.1 0.1 2.4e-17 63.0 0.0 2.2 2 0 0 2 2 2 1 Toprim domain HATPase_c_3 PF13589.6 CDW59242.1 - 0.0003 20.6 2.6 0.00063 19.6 0.0 2.6 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MRG PF05712.13 CDW59242.1 - 0.11 11.8 0.0 0.28 10.5 0.0 1.6 1 0 0 1 1 1 0 MRG S4_2 PF13275.6 CDW59243.1 - 5.3e-24 83.8 0.1 1.5e-23 82.3 0.0 1.8 2 0 0 2 2 2 1 S4 domain Bac_DnaA PF00308.18 CDW59243.1 - 9e-16 58.4 4.5 6.3e-15 55.6 0.1 3.7 4 0 0 4 4 4 1 Bacterial dnaA protein SMC_N PF02463.19 CDW59243.1 - 4.7e-14 52.4 1.4 1.9e-13 50.4 1.4 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDW59243.1 - 1e-09 38.6 14.2 6e-08 32.8 14.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain DNA_pol3_beta_3 PF02768.15 CDW59243.1 - 2.2e-09 37.2 0.0 5.2e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase III beta subunit, C-terminal domain DNA_pol3_beta PF00712.19 CDW59243.1 - 2.2e-09 37.5 0.0 4.1e-07 30.1 0.0 3.0 2 1 1 3 3 3 1 DNA polymerase III beta subunit, N-terminal domain DNA_pol3_beta_2 PF02767.16 CDW59243.1 - 1.4e-07 31.7 0.0 6.1e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase III beta subunit, central domain AAA_23 PF13476.6 CDW59243.1 - 1.2e-06 29.1 13.4 6.6e-06 26.8 13.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 CDW59243.1 - 4.7e-05 23.3 1.4 0.0023 17.8 1.4 2.6 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_27 PF13514.6 CDW59243.1 - 0.029 14.0 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CDW59243.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GIDA PF01134.22 CDW59244.1 - 6e-146 486.5 0.4 6e-146 486.5 0.4 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CDW59244.1 - 1.1e-78 264.3 3.8 1.1e-78 264.3 3.8 2.1 2 0 0 2 2 2 1 GidA associated domain MnmE_helical PF12631.7 CDW59244.1 - 9.7e-45 153.3 0.7 1.4e-42 146.2 4.5 2.3 2 1 0 2 2 2 1 MnmE helical domain TrmE_N PF10396.9 CDW59244.1 - 1.1e-42 145.0 0.0 3.4e-42 143.4 0.0 1.9 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 CDW59244.1 - 1.7e-24 86.1 0.3 6.6e-24 84.2 0.1 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase Jag_N PF14804.6 CDW59244.1 - 3.6e-15 56.0 0.1 1.6e-14 54.0 0.1 2.3 1 0 0 1 1 1 1 Jag N-terminus RsgA_GTPase PF03193.16 CDW59244.1 - 2.7e-07 30.6 1.0 0.004 17.1 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase FeoB_N PF02421.18 CDW59244.1 - 3.4e-07 29.9 0.2 3.4e-07 29.9 0.2 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 CDW59244.1 - 3.6e-06 26.5 1.2 4e-05 23.1 0.0 2.8 3 0 0 3 3 3 1 AIG1 family Dynamin_N PF00350.23 CDW59244.1 - 1.3e-05 25.4 0.0 0.057 13.5 0.0 3.0 1 1 1 2 2 2 2 Dynamin family MMR_HSR1_Xtn PF16897.5 CDW59244.1 - 0.039 14.0 0.1 0.18 11.9 0.0 2.2 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain ABC_tran PF00005.27 CDW59244.1 - 0.052 14.1 0.0 0.22 12.1 0.0 2.1 1 0 0 1 1 1 0 ABC transporter Ras PF00071.22 CDW59244.1 - 0.057 13.0 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 Ras family AAA_16 PF13191.6 CDW59244.1 - 0.067 13.6 1.1 0.2 12.0 0.2 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_31 PF13614.6 CDW59245.1 - 4.3e-70 235.2 0.2 1.3e-69 233.7 0.2 1.9 1 0 0 1 1 1 1 AAA domain ParBc PF02195.18 CDW59245.1 - 1.7e-28 98.7 0.0 4.7e-28 97.3 0.0 1.8 1 0 0 1 1 1 1 ParB-like nuclease domain CbiA PF01656.23 CDW59245.1 - 3e-28 98.4 0.1 7.8e-28 97.1 0.1 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain HTH_ParB PF17762.1 CDW59245.1 - 1.1e-15 57.1 3.4 1.1e-15 57.1 3.4 2.4 2 0 0 2 2 2 1 HTH domain found in ParB protein CBP_BcsQ PF06564.12 CDW59245.1 - 8.6e-14 51.6 0.0 1.6e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ParA PF10609.9 CDW59245.1 - 2.1e-13 50.3 0.3 7.9e-13 48.4 0.3 2.0 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 CDW59245.1 - 4.9e-12 45.7 0.7 3.8e-10 39.5 0.7 2.5 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.18 CDW59245.1 - 2e-10 40.6 3.8 2.3e-10 40.4 1.2 2.3 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family KorB PF08535.10 CDW59245.1 - 6.2e-06 26.2 0.2 6.2e-05 22.9 0.0 2.4 1 1 1 2 2 2 1 KorB domain ArsA_ATPase PF02374.15 CDW59245.1 - 1.7e-05 24.2 0.9 1.7e-05 24.2 0.9 3.0 3 2 0 3 3 3 1 Anion-transporting ATPase UPF0175 PF03683.13 CDW59245.1 - 3e-05 23.6 0.9 9.3e-05 22.1 0.1 2.3 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0175) SRP54 PF00448.22 CDW59245.1 - 5.8e-05 22.8 0.4 0.05 13.2 0.4 2.7 2 1 0 2 2 2 2 SRP54-type protein, GTPase domain HTH_3 PF01381.22 CDW59245.1 - 6.5e-05 22.9 0.1 0.00095 19.2 0.0 2.7 2 0 0 2 2 2 1 Helix-turn-helix VirC1 PF07015.11 CDW59245.1 - 0.00047 19.5 0.2 0.00047 19.5 0.2 2.3 3 0 0 3 3 3 1 VirC1 protein TrmB PF01978.19 CDW59245.1 - 0.0017 18.2 1.1 0.0076 16.1 0.2 2.4 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_19 PF12844.7 CDW59245.1 - 0.0019 18.2 0.0 0.011 15.7 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 CDW59245.1 - 0.0029 17.5 0.3 0.032 14.1 0.0 2.7 2 1 1 3 3 3 1 MarR family HTH_24 PF13412.6 CDW59245.1 - 0.02 14.5 0.0 0.083 12.5 0.0 2.0 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_31 PF13560.6 CDW59245.1 - 0.084 13.2 0.0 0.63 10.4 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain YchF-GTPase_C PF06071.13 CDW59246.1 - 4.5e-41 138.9 0.1 9.9e-41 137.8 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CDW59246.1 - 1.5e-25 89.5 0.1 2.8e-24 85.4 0.0 2.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW59246.1 - 6.5e-09 35.5 0.2 2.2e-08 33.8 0.0 2.2 2 1 0 2 2 2 1 Ferrous iron transport protein B DUF2540 PF10802.8 CDW59246.1 - 0.32 11.1 3.1 1.9 8.6 0.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2540) MFS_1 PF07690.16 CDW59247.1 - 1.4e-24 86.7 34.6 8.5e-23 80.8 30.2 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CDW59247.1 - 0.41 9.1 33.0 0.0073 14.9 18.7 3.5 2 2 1 3 3 3 0 MFS/sugar transport protein DnaB_C PF03796.15 CDW59248.1 - 7.7e-43 146.7 0.5 1.2e-42 146.1 0.5 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ERF PF04404.12 CDW59248.1 - 5.5e-14 52.3 0.0 1.4e-13 51.0 0.0 1.7 1 0 0 1 1 1 1 ERF superfamily ATPase PF06745.13 CDW59248.1 - 1.2e-08 34.6 2.1 1.6e-08 34.2 0.3 2.0 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 CDW59248.1 - 1.3e-08 34.6 0.0 2.5e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain DnaB PF00772.21 CDW59248.1 - 1.7e-07 31.2 0.6 1.2e-06 28.6 0.0 2.6 2 1 1 3 3 2 1 DnaB-like helicase N terminal domain KdpD PF02702.17 CDW59248.1 - 2.8e-05 23.7 1.1 0.00098 18.6 0.1 2.9 2 1 0 2 2 2 1 Osmosensitive K+ channel His kinase sensor domain IstB_IS21 PF01695.17 CDW59248.1 - 0.00015 21.6 1.9 0.00099 18.9 0.2 2.7 3 1 0 3 3 3 1 IstB-like ATP binding protein SRP54 PF00448.22 CDW59248.1 - 0.00082 19.1 0.1 0.0021 17.7 0.1 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Sipho_Gp157 PF05565.11 CDW59248.1 - 0.0032 17.5 4.9 0.0032 17.5 4.9 2.4 3 0 0 3 3 3 1 Siphovirus Gp157 ResIII PF04851.15 CDW59248.1 - 0.0078 16.2 0.6 0.02 14.9 0.3 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 CDW59248.1 - 0.0096 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_31 PF13614.6 CDW59248.1 - 0.011 15.7 2.8 0.016 15.2 0.5 2.5 2 1 0 2 2 2 0 AAA domain CbiA PF01656.23 CDW59248.1 - 0.014 15.5 0.4 0.059 13.4 0.3 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 CDW59248.1 - 0.017 14.9 0.7 0.71 9.6 0.3 2.4 1 1 1 2 2 2 0 AAA domain AAA_30 PF13604.6 CDW59248.1 - 0.018 14.8 0.2 0.059 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain ArsA_ATPase PF02374.15 CDW59248.1 - 0.018 14.2 0.3 0.07 12.3 0.1 2.1 1 1 1 2 2 2 0 Anion-transporting ATPase PhoH PF02562.16 CDW59248.1 - 0.03 13.8 0.1 0.061 12.8 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein Flp_Fap PF04964.14 CDW59248.1 - 0.11 12.3 1.7 0.26 11.1 1.7 1.5 1 0 0 1 1 1 0 Flp/Fap pilin component DUF2612 PF11041.8 CDW59249.1 - 6.1e-12 45.8 0.1 1.7e-09 37.9 0.0 4.0 3 1 2 5 5 5 1 Protein of unknown function (DUF2612) DUF2184 PF09950.9 CDW59249.1 - 9.1e-08 31.8 3.3 1.4e-07 31.2 0.4 2.5 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2184) DUF2190 PF09956.9 CDW59249.1 - 0.22 12.1 15.6 0.02 15.4 8.2 3.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2190) CTU2 PF10288.9 CDW59250.1 - 0.45 10.8 3.6 0.26 11.6 1.4 1.7 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Sec62 PF03839.16 CDW59250.1 - 0.49 9.9 3.4 0.9 9.0 3.4 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 SID-1_RNA_chan PF13965.6 CDW59250.1 - 1.5 7.2 3.9 1.8 6.9 3.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Orf78 PF06024.12 CDW59250.1 - 2 8.8 4.4 5.4 7.4 4.4 1.8 1 1 0 1 1 1 0 Orf78 (ac78) DUF134 PF02001.16 CDW59251.1 - 0.17 12.5 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF134 Sel1 PF08238.12 CDW59252.1 - 7.2e-18 64.6 3.3 0.0015 19.1 0.0 5.2 5 0 0 5 5 5 4 Sel1 repeat DUF1955 PF09205.10 CDW59252.1 - 0.054 13.2 4.3 2.7 7.7 0.0 3.2 1 1 3 4 4 4 0 Domain of unknown function (DUF1955) DIOX_N PF14226.6 CDW59252.1 - 0.075 13.8 0.1 1.6 9.5 0.0 2.6 2 1 1 3 3 3 0 non-haem dioxygenase in morphine synthesis N-terminal TPR_2 PF07719.17 CDW59252.1 - 0.52 10.6 3.8 11 6.4 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Maf1 PF09174.10 CDW59253.1 - 1.2e-33 116.7 0.0 1e-15 58.3 0.0 2.1 1 1 1 2 2 2 2 Maf1 regulator WH2 PF02205.20 CDW59254.1 - 2.7e-05 23.8 0.1 5.5e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 WH2 motif SlyX PF04102.12 CDW59254.1 - 1.1 9.9 5.7 3.5 8.3 0.1 3.2 2 1 0 2 2 2 0 SlyX NRDD PF13597.6 CDW59255.1 - 1.2e-134 450.2 0.0 1.5e-134 449.8 0.0 1.0 1 0 0 1 1 1 1 Anaerobic ribonucleoside-triphosphate reductase Fer4_12 PF13353.6 CDW59255.1 - 4e-33 114.6 0.0 1e-32 113.3 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S single cluster domain Gly_radical PF01228.21 CDW59255.1 - 2.6e-27 95.4 0.0 5.4e-27 94.4 0.0 1.6 1 0 0 1 1 1 1 Glycine radical Fer4_14 PF13394.6 CDW59255.1 - 3.6e-22 78.7 0.0 7.5e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain OrfB_Zn_ribbon PF07282.11 CDW59255.1 - 0.11 12.5 1.4 0.3 11.0 1.4 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Anti-TRAP PF15777.5 CDW59255.1 - 0.32 11.0 2.4 0.75 9.8 2.4 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein NOB1_Zn_bind PF08772.11 CDW59255.1 - 0.4 10.9 3.6 0.84 9.8 3.6 1.5 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like HypA PF01155.19 CDW59255.1 - 0.66 10.0 1.9 1.4 8.9 1.9 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 CDW59255.1 - 1 9.4 5.2 0.9 9.6 2.4 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain PmbA_TldD PF01523.16 CDW59256.1 - 3.1e-60 204.4 0.3 1.3e-59 202.4 0.0 2.0 2 0 0 2 2 2 1 Putative modulator of DNA gyrase Cytochrom_B562 PF07361.11 CDW59256.1 - 8.3e-31 106.7 4.7 2.2e-30 105.3 4.7 1.8 1 0 0 1 1 1 1 Cytochrome b562 Mur_ligase_M PF08245.12 CDW59256.1 - 1.3e-17 64.5 0.0 2.2e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 Mur ligase middle domain Mur_ligase PF01225.25 CDW59256.1 - 1.4e-14 54.1 0.0 7e-14 51.9 0.0 2.3 2 0 0 2 2 2 1 Mur ligase family, catalytic domain Mur_ligase_C PF02875.21 CDW59256.1 - 5.8e-10 39.3 0.0 2.2e-09 37.4 0.0 2.1 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain FBPase PF00316.20 CDW59257.1 - 3.1e-85 284.4 0.2 4e-85 284.1 0.2 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CDW59257.1 - 0.14 11.7 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family BPD_transp_2 PF02653.16 CDW59258.1 - 1.1e-87 293.7 90.3 1.4e-45 155.5 39.7 2.2 2 0 0 2 2 2 2 Branched-chain amino acid transport system / permease component DUF4229 PF14012.6 CDW59258.1 - 0.2 11.8 0.1 0.2 11.8 0.1 6.2 6 3 2 8 8 8 0 Protein of unknown function (DUF4229) DUF5423 PF17461.2 CDW59258.1 - 9.9 4.9 6.0 36 3.1 6.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5423) ABC_tran PF00005.27 CDW59259.1 - 1.1e-51 174.9 0.0 1.7e-30 106.3 0.0 2.4 2 0 0 2 2 2 2 ABC transporter Peripla_BP_4 PF13407.6 CDW59259.1 - 1.2e-44 152.8 4.3 7.9e-44 150.2 5.7 1.6 2 0 0 2 2 2 1 Periplasmic binding protein domain Peripla_BP_1 PF00532.21 CDW59259.1 - 1.1e-15 57.8 0.2 2.4e-15 56.7 0.2 1.5 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family AAA_21 PF13304.6 CDW59259.1 - 1.6e-14 54.4 2.9 0.00014 21.8 0.1 3.2 2 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW59259.1 - 3.4e-05 23.5 0.1 9.2e-05 22.1 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 CDW59259.1 - 8.6e-05 22.1 0.5 0.57 9.6 0.0 3.6 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Peripla_BP_6 PF13458.6 CDW59259.1 - 0.00016 21.5 0.3 0.00047 19.9 0.3 1.7 1 1 0 1 1 1 1 Periplasmic binding protein ABC_sub_bind PF04392.12 CDW59259.1 - 0.00025 20.4 0.9 0.021 14.1 0.2 2.2 2 0 0 2 2 2 1 ABC transporter substrate binding protein RsgA_GTPase PF03193.16 CDW59259.1 - 0.00026 21.0 0.0 0.00063 19.7 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Peripla_BP_3 PF13377.6 CDW59259.1 - 0.00046 20.5 0.0 0.0049 17.2 0.0 2.3 2 0 0 2 2 2 1 Periplasmic binding protein-like domain AAA_23 PF13476.6 CDW59259.1 - 0.00076 20.0 0.0 0.0024 18.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW59259.1 - 0.0009 19.7 0.6 0.018 15.4 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 CDW59259.1 - 0.0012 18.6 0.1 0.0091 15.7 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDW59259.1 - 0.0017 18.6 1.8 0.02 15.2 0.4 3.0 2 1 0 2 2 2 1 AAA domain ABC_ATPase PF09818.9 CDW59259.1 - 0.0037 16.1 2.9 1.2 7.9 0.1 3.6 3 1 0 3 3 3 1 Predicted ATPase of the ABC class MMR_HSR1 PF01926.23 CDW59259.1 - 0.009 16.1 0.0 0.042 13.9 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2813 PF11398.8 CDW59259.1 - 0.016 14.5 0.0 0.048 12.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) SbcCD_C PF13558.6 CDW59259.1 - 0.031 14.5 0.1 16 5.8 0.0 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.17 CDW59259.1 - 0.045 13.5 0.5 1.3 8.7 0.0 2.5 3 0 0 3 3 2 0 IstB-like ATP binding protein AAA_15 PF13175.6 CDW59259.1 - 0.064 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 CDW59259.1 - 0.093 13.0 0.0 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 CDW59259.1 - 0.097 11.3 0.0 6.2 5.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDW59259.1 - 0.098 12.7 0.4 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 CDW59259.1 - 0.13 11.4 0.0 0.26 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DLIC PF05783.11 CDW59259.1 - 0.18 10.6 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Pyrophosphatase PF00719.19 CDW59260.1 - 3.1e-56 189.6 0.0 3.5e-56 189.5 0.0 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase InPase PF18823.1 CDW59260.1 - 0.027 14.2 0.1 0.08 12.6 0.0 1.7 2 0 0 2 2 2 0 Inorganic Pyrophosphatase PemK_toxin PF02452.17 CDW59261.1 - 4.4e-19 68.9 0.0 6.8e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 PemK-like, MazF-like toxin of type II toxin-antitoxin system MazE_antitoxin PF04014.18 CDW59261.1 - 1e-08 34.9 0.0 1.8e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin TamB PF04357.13 CDW59262.1 - 2.5e-66 224.5 0.7 2.5e-66 224.5 0.7 5.1 5 1 0 5 5 5 2 TamB, inner membrane protein subunit of TAM complex Bac_surface_Ag PF01103.23 CDW59262.1 - 8.4e-29 101.1 4.9 3e-28 99.3 5.0 1.8 1 1 0 1 1 1 1 Surface antigen GGACT PF06094.12 CDW59262.1 - 7.4e-23 81.5 0.1 2e-22 80.1 0.1 1.8 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like POTRA_TamA_1 PF17243.2 CDW59262.1 - 1.2e-20 73.3 0.0 3.1e-20 72.0 0.0 1.8 1 0 0 1 1 1 1 POTRA domain TamA domain 1 POTRA PF07244.15 CDW59262.1 - 2.3e-13 50.5 0.5 6.9e-08 33.0 0.0 4.6 4 0 0 4 4 4 2 Surface antigen variable number repeat T2SSN PF01203.19 CDW59262.1 - 1.2e-05 25.6 24.0 0.0081 16.4 1.2 6.1 3 2 2 6 6 6 3 Type II secretion system (T2SS), protein N Bactofilin PF04519.13 CDW59262.1 - 0.042 14.2 2.6 5.1 7.5 0.0 4.9 5 0 0 5 5 5 0 Polymer-forming cytoskeletal PMSR PF01625.21 CDW59263.1 - 7.8e-68 227.5 0.2 9.3e-68 227.2 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase YtfJ_HI0045 PF09695.10 CDW59264.1 - 2.4e-43 147.5 0.0 2.8e-43 147.3 0.0 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (YtfJ_HI0045) Pyridox_ox_2 PF12900.7 CDW59264.1 - 0.035 14.1 0.0 0.08 12.9 0.0 1.6 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Inositol_P PF00459.25 CDW59265.1 - 5.3e-49 167.2 0.0 6.5e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Metallophos PF00149.28 CDW59266.1 - 1.4e-08 35.5 0.0 1.8e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mcm10 PF09332.11 CDW59267.1 - 1.7e-47 162.6 11.9 1.7e-47 162.6 11.9 1.3 1 1 0 1 1 1 1 Mcm10 replication factor zf-primase PF09329.11 CDW59267.1 - 1.5e-05 24.7 0.4 1.5e-05 24.7 0.4 2.3 2 0 0 2 2 2 1 Primase zinc finger DUF1451 PF07295.11 CDW59267.1 - 0.017 15.2 10.2 0.058 13.4 8.6 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain Neuropep_like PF15161.6 CDW59267.1 - 0.049 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Neuropeptide-like TolB_like PF15869.5 CDW59267.1 - 0.055 12.7 0.3 0.069 12.4 0.3 1.1 1 0 0 1 1 1 0 TolB-like 6-blade propeller-like DZR PF12773.7 CDW59267.1 - 0.44 10.6 16.3 0.74 9.9 3.5 2.8 2 1 0 3 3 3 0 Double zinc ribbon C1_2 PF03107.16 CDW59267.1 - 0.55 10.6 6.3 9.4 6.6 0.5 2.7 2 0 0 2 2 2 0 C1 domain Zn-ribbon_8 PF09723.10 CDW59267.1 - 2.8 8.1 9.1 0.42 10.8 3.0 2.5 2 0 0 2 2 2 0 Zinc ribbon domain p450 PF00067.22 CDW59268.1 - 1e-69 235.5 0.1 5.8e-65 219.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 MFS_1_like PF12832.7 CDW59270.1 - 2.8e-97 326.0 10.7 3.6e-97 325.6 10.7 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 CDW59270.1 - 3.1e-24 85.6 36.7 1.4e-13 50.5 20.5 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Nuc_H_symport PF03825.16 CDW59270.1 - 2e-07 30.4 14.7 5.2e-06 25.7 2.5 3.1 3 0 0 3 3 3 3 Nucleoside H+ symporter MFS_2 PF13347.6 CDW59270.1 - 2.2e-07 29.8 8.3 2.4e-05 23.1 0.0 3.3 3 0 0 3 3 3 3 MFS/sugar transport protein LacY_symp PF01306.19 CDW59270.1 - 0.00037 19.4 18.0 0.016 14.0 3.0 3.5 3 1 0 3 3 3 2 LacY proton/sugar symporter CPP1-like PF11833.8 CDW59270.1 - 0.0044 16.7 1.6 0.041 13.5 0.0 2.7 3 0 0 3 3 3 1 Protein CHAPERONE-LIKE PROTEIN OF POR1-like TatD_DNase PF01026.21 CDW59271.1 - 6.6e-64 215.7 0.0 7.6e-64 215.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase 7tm_1 PF00001.21 CDW59273.1 - 7.2e-06 25.5 4.7 1.3e-05 24.7 4.7 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 CDW59273.1 - 1.6e-05 24.7 8.8 2.6e-05 24.0 8.8 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF5336 PF17270.2 CDW59273.1 - 0.019 14.6 0.4 0.075 12.7 0.0 1.9 1 1 0 2 2 2 0 Family of unknown function (DUF5336) RRM_1 PF00076.22 CDW59274.1 - 4.2e-20 71.3 0.0 6e-20 70.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CDW59274.1 - 9.9e-05 22.3 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CDW59274.1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CDW59274.1 - 0.045 13.8 0.1 0.073 13.1 0.1 1.3 1 0 0 1 1 1 0 Limkain b1 RRM_5 PF13893.6 CDW59274.1 - 0.15 11.6 0.0 0.16 11.6 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EB PF01683.18 CDW59275.1 - 4.6e-06 26.8 10.0 5.7e-06 26.5 10.0 1.2 1 0 0 1 1 1 1 EB module EB PF01683.18 CDW59276.1 - 0.15 12.3 12.9 0.075 13.3 3.3 2.3 2 0 0 2 2 2 0 EB module CC PF04942.14 CDW59276.1 - 1.2 9.4 23.7 1.2 9.4 7.6 4.1 4 0 0 4 4 4 0 CC domain Baculo_VP91_N PF08475.10 CDW59277.1 - 0.0054 16.4 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 Viral capsid protein 91 N-terminal CC PF04942.14 CDW59277.1 - 0.0067 16.6 7.5 0.0067 16.6 7.5 12.9 12 2 2 14 14 14 8 CC domain rve PF00665.26 CDW59278.1 - 0.0041 17.3 0.0 0.0089 16.2 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDW59278.1 - 0.45 10.8 1.8 0.77 10.0 0.9 1.9 2 0 0 2 2 2 0 H2C2 zinc finger Astacin PF01400.24 CDW59279.1 - 1.7e-36 125.6 0.2 2.8e-36 124.9 0.2 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 CDW59279.1 - 2.7e-16 59.8 40.1 7.8e-08 32.7 7.6 3.3 3 0 0 3 3 3 3 ShK domain-like PA PF02225.22 CDW59281.1 - 1.3e-05 25.1 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 PA domain ABC_tran PF00005.27 CDW59283.1 - 1.6e-36 125.9 0.0 2.1e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW59283.1 - 1.3e-12 48.1 0.0 1.8e-06 28.0 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW59283.1 - 4.4e-08 32.8 1.8 9e-05 22.0 0.2 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDW59283.1 - 8.3e-05 22.3 0.0 0.00017 21.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 CDW59283.1 - 0.00013 20.8 0.0 0.031 13.0 0.0 2.0 1 1 1 2 2 2 2 AAA domain ABC_ATPase PF09818.9 CDW59283.1 - 0.00016 20.6 1.0 0.67 8.7 0.1 3.0 2 1 0 2 2 2 2 Predicted ATPase of the ABC class AAA_15 PF13175.6 CDW59283.1 - 0.00017 21.4 0.0 0.0012 18.6 0.0 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 CDW59283.1 - 0.0037 17.8 0.1 0.0059 17.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain G-alpha PF00503.20 CDW59283.1 - 0.0042 16.3 0.0 0.0043 16.3 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit RsgA_GTPase PF03193.16 CDW59283.1 - 0.0064 16.4 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 CDW59283.1 - 0.011 15.1 0.0 0.023 14.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family SbcCD_C PF13558.6 CDW59283.1 - 0.013 15.8 0.1 0.18 12.0 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 CDW59283.1 - 0.015 15.7 0.1 0.022 15.2 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CDW59283.1 - 0.021 15.1 0.2 0.063 13.5 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDW59283.1 - 0.026 14.1 0.1 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDW59283.1 - 0.039 13.7 0.1 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDW59283.1 - 0.05 13.8 0.2 0.081 13.1 0.2 1.7 1 1 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 CDW59283.1 - 0.065 12.7 0.1 0.14 11.6 0.0 1.5 2 0 0 2 2 2 0 Poxvirus A32 protein NACHT PF05729.12 CDW59283.1 - 0.091 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 CDW59283.1 - 0.21 11.8 0.2 2.3 8.4 0.2 2.2 2 0 0 2 2 2 0 AAA domain SBP_bac_3 PF00497.20 CDW59284.1 - 7.5e-40 136.7 1.9 1.2e-39 136.0 1.9 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 BPD_transp_1 PF00528.22 CDW59284.1 - 2.6e-19 69.7 9.0 2.6e-19 69.7 9.0 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Lig_chan-Glu_bd PF10613.9 CDW59284.1 - 2.4e-09 37.4 0.0 1e-08 35.4 0.0 2.0 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_11 PF13531.6 CDW59284.1 - 0.072 12.8 0.0 0.32 10.7 0.0 1.9 1 1 1 2 2 2 0 Bacterial extracellular solute-binding protein FUSC_2 PF13515.6 CDW59284.1 - 3.5 7.7 11.2 0.85 9.7 4.9 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein-like SIR2 PF02146.17 CDW59285.1 - 5.2e-42 143.8 0.0 1e-41 142.8 0.0 1.5 1 0 0 1 1 1 1 Sir2 family 3H PF02829.14 CDW59285.1 - 1.5e-30 105.4 1.4 4.4e-30 103.8 1.4 1.9 1 0 0 1 1 1 1 3H domain CM_2 PF01817.21 CDW59285.1 - 2.7e-15 56.5 3.0 8.2e-15 54.9 2.2 2.3 1 1 1 2 2 2 1 Chorismate mutase type II Hexapep_2 PF14602.6 CDW59285.1 - 1.3e-12 47.3 13.1 1.5e-09 37.5 5.0 2.9 3 0 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase HTH_11 PF08279.12 CDW59285.1 - 3.8e-12 45.9 0.1 1.2e-11 44.4 0.1 1.9 1 0 0 1 1 1 1 HTH domain Hexapep PF00132.24 CDW59285.1 - 7.6e-11 41.3 14.7 3.3e-09 36.1 6.8 2.8 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 CDW59285.1 - 1.2e-06 28.7 0.1 4.5e-06 26.8 0.1 2.1 1 0 0 1 1 1 1 Maltose acetyltransferase TPP_enzyme_M PF00205.22 CDW59285.1 - 0.0011 18.7 0.2 0.3 10.8 0.0 2.9 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain PheRS_DBD1 PF18552.1 CDW59285.1 - 0.0019 17.9 0.4 0.0069 16.1 0.0 2.1 2 0 0 2 2 2 1 PheRS DNA binding domain 1 HTH_AsnC-type PF13404.6 CDW59285.1 - 0.13 12.1 0.4 3.5 7.5 0.0 2.5 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain HTH_28 PF13518.6 CDW59285.1 - 0.13 12.4 0.1 0.37 11.0 0.1 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Pep_deformylase PF01327.21 CDW59286.1 - 6.1e-44 149.4 0.0 6.9e-44 149.3 0.0 1.0 1 0 0 1 1 1 1 Polypeptide deformylase RNase_PH PF01138.21 CDW59287.1 - 1.9e-43 148.1 0.0 6.8e-21 75.1 0.0 2.5 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CDW59287.1 - 5.7e-23 80.7 6.3 7.6e-13 48.3 0.1 3.1 3 0 0 3 3 3 2 3' exoribonuclease family, domain 2 S1 PF00575.23 CDW59287.1 - 9.3e-19 67.6 5.9 3.2e-18 65.8 5.9 2.0 1 0 0 1 1 1 1 S1 RNA binding domain PNPase PF03726.14 CDW59287.1 - 3.8e-12 46.5 6.1 3.8e-12 46.5 6.1 2.8 2 0 0 2 2 2 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.29 CDW59287.1 - 2e-09 37.2 9.7 2.5e-09 36.8 6.6 2.5 2 0 0 2 2 2 1 KH domain SPATA25 PF15218.6 CDW59287.1 - 0.052 13.3 0.2 0.1 12.3 0.2 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated protein 25 S1_2 PF13509.6 CDW59287.1 - 0.087 12.9 0.2 0.28 11.3 0.2 2.0 1 0 0 1 1 1 0 S1 domain DUF3347 PF11827.8 CDW59287.1 - 0.19 11.9 1.7 0.46 10.6 1.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) MT0933_antitox PF14013.6 CDW59287.1 - 1.7 9.0 6.1 12 6.2 0.6 3.0 2 0 0 2 2 2 0 MT0933-like antitoxin protein Bacillus_HBL PF05791.11 CDW59287.1 - 2.1 8.1 6.0 3.9 7.3 1.1 2.4 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) K_trans PF02705.16 CDW59288.1 - 9.5e-170 565.6 25.3 1.1e-169 565.4 25.3 1.0 1 0 0 1 1 1 1 K+ potassium transporter Ribosomal_TL5_C PF14693.6 CDW59289.1 - 3.5e-23 81.8 1.5 1.1e-22 80.2 0.9 2.0 2 0 0 2 2 2 1 Ribosomal protein TL5, C-terminal domain Ribosomal_L25p PF01386.19 CDW59289.1 - 8.4e-19 67.9 0.1 1.4e-18 67.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal L25p family DUF960 PF06124.11 CDW59289.1 - 1.9e-18 66.9 0.0 7.2e-14 52.2 0.0 2.5 1 1 1 2 2 2 2 Staphylococcal protein of unknown function (DUF960) PRK PF00485.18 CDW59290.1 - 1.3e-48 165.4 0.9 1.5e-48 165.1 0.9 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CDW59290.1 - 2.8e-09 37.6 0.1 4.6e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 CDW59290.1 - 3.9e-05 23.4 1.4 0.0019 17.9 1.4 2.3 1 1 0 1 1 1 1 Dephospho-CoA kinase Zeta_toxin PF06414.12 CDW59290.1 - 0.00089 18.6 0.0 0.0019 17.5 0.0 1.5 2 0 0 2 2 2 1 Zeta toxin CPT PF07931.12 CDW59290.1 - 0.0096 15.8 0.0 0.02 14.7 0.0 1.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Cytidylate_kin PF02224.18 CDW59290.1 - 0.0099 15.6 0.0 3 7.5 0.0 2.2 2 0 0 2 2 2 2 Cytidylate kinase AAA_17 PF13207.6 CDW59290.1 - 0.011 16.1 0.4 1.8 9.0 0.3 2.3 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 CDW59290.1 - 0.012 14.7 0.2 0.044 12.8 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Thymidylate_kin PF02223.17 CDW59290.1 - 0.012 15.3 0.1 0.9 9.2 0.0 2.4 2 1 0 2 2 2 0 Thymidylate kinase Gtr1_RagA PF04670.12 CDW59290.1 - 0.025 13.9 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 CDW59290.1 - 0.032 14.7 0.0 0.038 14.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 CDW59290.1 - 0.041 14.3 0.0 0.062 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 CDW59290.1 - 0.058 13.6 0.0 0.13 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDW59290.1 - 0.1 12.9 0.0 0.17 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDW59290.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDW59290.1 - 0.13 11.4 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain His_Phos_1 PF00300.22 CDW59291.1 - 4.8e-35 121.0 0.0 7.7e-26 91.0 0.1 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Rib_5-P_isom_A PF06026.14 CDW59292.1 - 1.1e-61 207.4 0.0 1.4e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CDW59292.1 - 1.4e-05 25.1 0.1 3.9e-05 23.6 0.0 1.8 2 1 0 2 2 2 1 DeoR C terminal sensor domain CoA_trans PF01144.23 CDW59292.1 - 0.018 14.4 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase DUF2478 PF10649.9 CDW59292.1 - 0.022 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2478) Ribosomal_S7 PF00177.21 CDW59293.1 - 1e-63 213.4 1.1 1.4e-63 213.0 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ribosom_S12_S23 PF00164.25 CDW59293.1 - 1.7e-26 92.1 0.0 3.2e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S12/S23 GTP_EFTU PF00009.27 CDW59294.1 - 4.1e-69 232.0 0.4 6.6e-69 231.3 0.4 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CDW59294.1 - 1.2e-47 160.7 0.3 3.1e-47 159.3 0.1 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 CDW59294.1 - 1e-33 115.2 0.1 2.7e-33 113.9 0.1 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDW59294.1 - 1.7e-32 111.3 0.4 2.4e-31 107.6 0.1 2.6 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDW59294.1 - 8.8e-16 58.1 0.1 3.8e-15 56.0 0.1 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CDW59294.1 - 1.3e-06 28.2 0.0 3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CDW59294.1 - 5e-05 23.3 0.0 0.00013 22.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CDW59294.1 - 0.0022 17.4 0.0 0.0049 16.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 CDW59294.1 - 0.095 12.1 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDW59295.1 - 3e-62 209.6 0.1 3.5e-62 209.4 0.1 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CDW59295.1 - 8.7e-06 25.8 0.0 1.6e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 CDW59295.1 - 6.4e-05 23.3 1.1 0.00014 22.2 1.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 CDW59295.1 - 0.019 14.9 0.0 0.052 13.4 0.0 1.7 1 1 1 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 CDW59295.1 - 0.031 14.0 0.2 2 8.2 0.1 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 CDW59295.1 - 0.032 13.8 0.4 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Cas9_b_hairpin PF17893.1 CDW59295.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated endonuclease Cas9 beta-hairpin domain FeoB_N PF02421.18 CDW59295.1 - 0.69 9.4 2.6 14 5.1 0.2 2.9 2 1 0 2 2 2 0 Ferrous iron transport protein B Serpin PF00079.20 CDW59296.1 - 2.8e-153 510.6 10.4 3.3e-110 368.9 1.2 2.8 1 1 1 2 2 2 2 Serpin (serine protease inhibitor) GerE PF00196.19 CDW59296.1 - 0.049 13.2 0.3 13 5.4 0.0 2.8 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Ribosomal_L30 PF00327.20 CDW59296.1 - 0.064 13.2 0.0 7.4 6.6 0.0 2.6 2 0 0 2 2 2 0 Ribosomal protein L30p/L7e LBP_C PF17386.2 CDW59296.1 - 0.91 9.5 2.3 36 4.3 0.2 2.4 2 0 0 2 2 2 0 Lacto-N-biose phosphorylase C-terminal domain Bromodomain PF00439.25 CDW59297.1 - 1.5e-11 44.2 0.0 7.1e-11 42.0 0.0 2.2 2 0 0 2 2 2 1 Bromodomain zf-MYND PF01753.18 CDW59297.1 - 0.00043 20.3 19.1 0.00043 20.3 19.1 4.1 3 2 1 4 4 4 2 MYND finger SWI-SNF_Ssr4 PF08549.10 CDW59297.1 - 0.21 10.2 4.8 0.034 12.8 1.1 1.4 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) Exonuc_VII_L PF02601.15 CDW59297.1 - 0.51 9.8 2.9 0.54 9.8 2.0 1.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit PHD PF00628.29 CDW59297.1 - 0.72 9.8 28.0 0.075 12.9 3.9 4.0 3 2 1 4 4 4 0 PHD-finger Mitofilin PF09731.9 CDW59297.1 - 1.8 7.3 17.2 0.063 12.1 10.9 1.6 2 0 0 2 2 2 0 Mitochondrial inner membrane protein F-box PF00646.33 CDW59298.1 - 0.0094 15.8 0.8 0.034 14.0 0.8 2.0 1 0 0 1 1 1 1 F-box domain NAPRTase_C PF17956.1 CDW59298.1 - 0.042 14.3 0.0 0.078 13.4 0.0 1.4 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain Regnase_1_C PF18561.1 CDW59298.1 - 0.098 12.4 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain RNase_T PF00929.24 CDW59300.1 - 1.8e-07 31.8 0.0 2.6e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 CDW59300.1 - 2.7e-05 23.9 0.0 0.00011 22.0 0.0 1.8 2 0 0 2 2 2 1 3'-5' exonuclease DUF5101 PF17031.5 CDW59300.1 - 0.069 13.3 0.2 3.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) Radical_SAM PF04055.21 CDW59302.1 - 4.1e-33 115.1 0.1 8.7e-33 114.0 0.1 1.6 2 0 0 2 2 2 1 Radical SAM superfamily UPF0004 PF00919.20 CDW59302.1 - 1.8e-05 24.7 0.3 5.6e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 CDW59302.1 - 0.00072 19.5 0.0 0.0018 18.2 0.0 1.6 1 0 0 1 1 1 1 TRAM domain Fer4_12 PF13353.6 CDW59302.1 - 0.082 13.2 0.4 0.21 11.9 0.4 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain dsrm PF00035.26 CDW59303.1 - 0.05 14.3 0.0 0.05 14.3 0.0 2.8 3 0 0 3 3 3 0 Double-stranded RNA binding motif MRI PF15325.6 CDW59303.1 - 1.8 9.7 5.4 4.2 8.5 5.4 1.6 1 0 0 1 1 1 0 Modulator of retrovirus infection Glycos_transf_2 PF00535.26 CDW59304.1 - 2.9e-15 56.5 0.0 2.7e-14 53.3 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 CDW59304.1 - 1.6e-05 24.4 0.0 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 CDW59304.1 - 0.015 14.7 0.0 0.031 13.8 0.0 1.5 1 1 0 1 1 1 0 Glycosyltransferase like family 2 RRM_1 PF00076.22 CDW59305.1 - 4e-30 103.4 0.0 1.6e-14 53.5 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW59305.1 - 0.09 12.9 0.0 0.65 10.2 0.0 2.3 2 1 0 2 2 2 0 RNA recognition motif dsrm PF00035.26 CDW59307.1 - 9.1e-10 39.1 7.0 1.9e-05 25.3 2.5 3.7 2 1 0 2 2 2 2 Double-stranded RNA binding motif Med15 PF09606.10 CDW59308.1 - 2.8e-34 119.0 87.7 2.7e-26 92.6 82.5 3.0 1 1 1 2 2 2 2 ARC105 or Med15 subunit of Mediator complex non-fungal SUIM_assoc PF16619.5 CDW59308.1 - 0.0076 16.3 1.8 0.0076 16.3 1.8 3.0 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 KIX PF02172.16 CDW59308.1 - 0.01 16.1 0.1 0.03 14.6 0.1 1.7 1 0 0 1 1 1 0 KIX domain Pam16 PF03656.13 CDW59309.1 - 2.8e-36 124.3 9.4 1.5e-35 122.0 9.4 1.8 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 CDW59309.1 - 0.043 13.9 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 DnaJ domain Copine PF07002.16 CDW59310.1 - 3.1e-75 252.4 0.0 4.2e-75 251.9 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 CDW59310.1 - 5.8e-14 52.2 0.0 7.6e-09 35.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 CDW59310.1 - 0.0003 21.0 0.0 0.00058 20.0 0.0 1.5 1 0 0 1 1 1 1 vWA found in TerF C terminus zf-BED PF02892.15 CDW59311.1 - 0.002 18.1 0.0 0.0041 17.1 0.0 1.5 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_12 PF18658.1 CDW59311.1 - 0.053 13.1 0.0 0.094 12.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger C2H2-type TIM21 PF08294.11 CDW59312.1 - 1.8e-29 102.5 0.4 2.7e-29 101.9 0.4 1.2 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 CDW59312.1 - 3.6e-06 26.7 0.1 1e-05 25.2 0.1 1.7 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Chordopox_A13L PF05961.11 CDW59312.1 - 0.088 13.0 0.2 0.2 11.9 0.2 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein CECR6_TMEM121 PF14997.6 CDW59313.1 - 1.3e-49 168.7 8.3 1.3e-49 168.7 8.3 1.7 2 0 0 2 2 2 1 CECR6/TMEM121 family UPF0370 PF13980.6 CDW59313.1 - 3.3 7.8 5.7 8.1 6.6 5.7 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) PIG-P PF08510.12 CDW59313.1 - 3.9 7.4 8.4 1.2 9.1 4.2 2.2 1 1 1 2 2 2 0 PIG-P DUF2085 PF09858.9 CDW59313.1 - 4 8.0 9.8 0.84 10.2 4.8 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2085) Peptidase_M13_N PF05649.13 CDW59314.1 - 2e-82 277.9 0.5 2.7e-82 277.5 0.5 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CDW59314.1 - 8.4e-72 241.1 0.3 1.3e-71 240.5 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M13 Ecm29 PF13001.7 CDW59314.1 - 0.15 10.7 0.0 0.25 9.9 0.0 1.3 1 0 0 1 1 1 0 Proteasome stabiliser ParA PF10609.9 CDW59315.1 - 2.4e-93 312.1 0.0 2.8e-93 311.9 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CDW59315.1 - 4e-09 36.6 0.0 7.8e-09 35.7 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CDW59315.1 - 3.7e-07 30.2 0.0 3.2e-06 27.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 CDW59315.1 - 7.2e-05 22.1 0.5 0.0016 17.7 0.0 2.5 2 1 0 2 2 2 1 Anion-transporting ATPase Rad17 PF03215.15 CDW59315.1 - 0.00095 19.1 0.0 0.0022 17.9 0.0 1.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 CDW59315.1 - 0.0011 19.4 0.0 0.0015 18.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain CLP1_P PF16575.5 CDW59315.1 - 0.0013 18.5 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_25 PF13481.6 CDW59315.1 - 0.0025 17.4 0.0 0.0035 16.9 0.0 1.4 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 CDW59315.1 - 0.0038 16.5 0.0 0.013 14.8 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 CDW59315.1 - 0.004 17.0 0.0 1.9 8.3 0.1 2.1 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CDW59315.1 - 0.0065 17.0 0.0 0.014 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDW59315.1 - 0.0066 16.4 0.5 0.02 14.8 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA PF00004.29 CDW59315.1 - 0.021 15.3 0.0 0.043 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 CDW59315.1 - 0.023 14.3 0.0 0.074 12.7 0.0 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 CDW59315.1 - 0.026 14.6 0.2 8.6 6.5 0.1 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CDW59315.1 - 0.043 13.1 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 CDW59315.1 - 0.051 14.0 0.0 0.089 13.2 0.0 1.4 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 CDW59315.1 - 0.054 12.7 0.1 0.086 12.0 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 CDW59315.1 - 0.085 13.1 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain PcrB PF01884.17 CDW59315.1 - 0.13 11.7 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 PcrB family AAA_29 PF13555.6 CDW59315.1 - 0.13 12.0 0.2 1 9.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain UQ_con PF00179.26 CDW59316.1 - 4.8e-38 130.0 0.3 5.2e-38 129.9 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CDW59316.1 - 2.7e-05 24.4 0.2 3.7e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 CDW59316.1 - 0.014 15.1 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 CDW59316.1 - 0.015 15.2 0.5 0.031 14.1 0.5 1.5 1 1 0 1 1 1 0 UEV domain Gal-bind_lectin PF00337.22 CDW59317.1 - 8.5e-67 222.8 0.1 1.6e-34 118.4 0.0 2.0 2 0 0 2 2 2 2 Galactoside-binding lectin GCP_C_terminal PF04130.13 CDW59318.1 - 1.2e-23 84.1 5.2 1.2e-18 67.7 4.5 2.2 1 1 1 2 2 2 2 Gamma tubulin complex component C-terminal HLH PF00010.26 CDW59319.1 - 1.8e-11 43.8 0.2 2.9e-11 43.2 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4271 PF14093.6 CDW59320.1 - 0.03 14.2 0.0 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4271) EGF_CA PF07645.15 CDW59321.1 - 5.1e-27 93.8 91.6 2.2e-08 34.2 9.4 6.2 7 0 0 7 7 7 5 Calcium-binding EGF domain EGF PF00008.27 CDW59321.1 - 1e-24 86.4 87.9 2.7e-06 27.6 7.8 6.8 7 0 0 7 7 7 5 EGF-like domain EGF_2 PF07974.13 CDW59321.1 - 2e-14 53.7 99.1 0.00093 19.5 11.2 7.3 7 0 0 7 7 7 6 EGF-like domain hEGF PF12661.7 CDW59321.1 - 1.9e-11 44.2 86.0 8.9e-06 26.2 6.6 8.7 8 0 0 8 8 8 5 Human growth factor-like EGF EGF_3 PF12947.7 CDW59321.1 - 9.5e-09 35.3 77.4 0.0051 17.0 5.7 6.9 4 2 2 6 6 6 5 EGF domain Laminin_EGF PF00053.24 CDW59321.1 - 0.00066 19.8 80.3 0.35 11.0 2.6 6.6 2 1 4 6 6 6 4 Laminin EGF domain cEGF PF12662.7 CDW59321.1 - 0.0055 16.6 66.2 0.16 12.0 1.3 8.4 6 2 0 6 6 6 4 Complement Clr-like EGF-like Peptidase_C42 PF05533.12 CDW59321.1 - 0.1 12.6 2.3 0.28 11.2 0.1 2.7 2 1 1 3 3 3 0 Beet yellows virus-type papain-like endopeptidase C42 FXa_inhibition PF14670.6 CDW59321.1 - 2.3 8.6 80.7 5 7.5 10.9 6.9 2 1 5 7 7 7 0 Coagulation Factor Xa inhibitory site DUF4704 PF15787.5 CDW59324.1 - 8.1e-77 258.2 5.0 8.1e-77 258.2 5.0 3.6 4 1 1 5 5 5 1 Domain of unknown function (DUF4704) Beach PF02138.18 CDW59324.1 - 8.4e-64 215.6 0.3 1e-62 212.1 0.3 2.1 1 1 0 1 1 1 1 Beige/BEACH domain DUF1088 PF06469.11 CDW59324.1 - 9.1e-52 175.1 0.2 2.2e-51 173.9 0.2 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1088) PH_BEACH PF14844.6 CDW59324.1 - 5.7e-23 80.9 0.0 2.2e-22 79.0 0.0 2.0 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 CDW59324.1 - 1.9e-08 34.6 0.1 3.3e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Stonin2_N PF12016.8 CDW59324.1 - 0.059 12.8 0.2 0.096 12.1 0.2 1.2 1 0 0 1 1 1 0 Stonin 2 Crisp PF08562.10 CDW59324.1 - 0.077 13.6 0.9 0.25 12.0 0.9 1.8 1 0 0 1 1 1 0 Crisp Mab-21 PF03281.14 CDW59325.1 - 4.9e-92 308.4 0.0 6.1e-92 308.1 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein Halogen_Hydrol PF10112.9 CDW59325.1 - 0.11 12.5 0.2 0.24 11.4 0.2 1.4 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein PH PF00169.29 CDW59327.1 - 0.11 13.0 0.2 8.8 6.9 0.1 2.4 2 0 0 2 2 2 0 PH domain His_Phos_2 PF00328.22 CDW59328.1 - 3.2e-05 23.4 3.8 0.00022 20.7 0.2 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Peptidase_C48 PF02902.19 CDW59329.1 - 7.6e-26 91.3 0.2 1.1e-25 90.7 0.2 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Pkinase PF00069.25 CDW59330.1 - 2.4e-28 99.2 0.0 3.1e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59330.1 - 2.4e-18 66.4 0.0 4.2e-18 65.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Filament PF00038.21 CDW59331.1 - 1.3e-56 192.4 67.9 2.4e-54 185.0 67.9 2.1 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 CDW59331.1 - 1.6e-16 60.6 0.0 3.9e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Lamin Tail Domain TPR_MLP1_2 PF07926.12 CDW59331.1 - 0.015 15.4 7.2 0.015 15.4 7.2 4.7 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein Leu_zip PF15294.6 CDW59331.1 - 0.19 11.2 59.0 0.29 10.6 13.2 3.2 1 1 2 3 3 3 0 Leucine zipper Fez1 PF06818.15 CDW59331.1 - 5.3 7.4 61.8 2.4 8.6 28.8 3.6 1 1 2 3 3 3 0 Fez1 Golgin_A5 PF09787.9 CDW59331.1 - 6.1 6.2 62.9 0.38 10.2 13.6 3.6 1 1 2 3 3 3 0 Golgin subfamily A member 5 PITH PF06201.13 CDW59332.1 - 1.5e-35 122.7 0.0 2e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 PITH domain OST-HTH PF12872.7 CDW59333.1 - 3.6e-05 23.5 0.0 6.4e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Tetraspanin PF00335.20 CDW59334.1 - 1.8e-43 148.9 11.0 2.2e-43 148.6 11.0 1.1 1 0 0 1 1 1 1 Tetraspanin family CD20 PF04103.15 CDW59334.1 - 0.068 13.3 8.9 0.035 14.2 5.4 2.0 2 0 0 2 2 2 0 CD20-like family Wzy_C PF04932.15 CDW59334.1 - 0.07 12.8 0.0 0.07 12.8 0.0 1.9 3 0 0 3 3 3 0 O-Antigen ligase SUR7 PF06687.12 CDW59334.1 - 2.8 7.5 13.7 35 3.9 13.1 2.6 2 1 0 2 2 2 0 SUR7/PalI family BTB_2 PF02214.22 CDW59335.1 - 2.8e-20 72.5 0.0 3.7e-20 72.1 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 CDW59335.1 - 8.3e-05 22.8 0.0 0.00012 22.3 0.0 1.2 1 0 0 1 1 1 1 BTB/POZ domain Cation_efflux PF01545.21 CDW59336.1 - 6.1e-25 88.1 4.1 3.6e-24 85.6 4.1 1.9 1 1 0 1 1 1 1 Cation efflux family ThrE PF06738.12 CDW59336.1 - 0.082 12.3 2.6 0.23 10.8 2.6 1.7 1 0 0 1 1 1 0 Putative threonine/serine exporter ZT_dimer PF16916.5 CDW59336.1 - 0.12 12.5 0.4 3.3 7.9 0.1 2.5 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter Deltameth_res PF16020.5 CDW59336.1 - 1 9.3 0.0 1 9.3 0.0 2.5 3 0 0 3 3 3 0 Deltamethrin resistance Spc7 PF08317.11 CDW59337.1 - 0.0027 16.7 2.6 0.0046 15.9 2.6 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein CENP-K PF11802.8 CDW59337.1 - 0.03 13.9 0.1 0.059 12.9 0.1 1.5 1 0 0 1 1 1 0 Centromere-associated protein K Retrotrans_gag PF03732.17 CDW59337.1 - 0.042 14.1 0.1 0.11 12.7 0.1 1.7 1 1 1 2 2 2 0 Retrotransposon gag protein Ntox28 PF15605.6 CDW59339.1 - 0.014 15.6 0.0 0.023 14.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 28 TPP_enzyme_N PF02776.18 CDW59341.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain HSP20 PF00011.21 CDW59342.1 - 3.6e-21 75.2 0.2 4.5e-21 74.9 0.2 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW59342.1 - 0.0041 16.7 0.0 0.0061 16.1 0.0 1.2 1 0 0 1 1 1 1 HSP20-like domain found in ArsA dsrm PF00035.26 CDW59344.1 - 0.00016 22.3 0.0 0.00029 21.5 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif HSP20 PF00011.21 CDW59345.1 - 4e-22 78.3 0.2 5.3e-22 77.9 0.2 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CDW59345.1 - 0.0042 16.6 0.0 0.0063 16.0 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA zf-CCHC PF00098.23 CDW59346.1 - 1.4e-06 28.1 9.7 3.9e-05 23.5 1.5 2.7 3 0 0 3 3 3 2 Zinc knuckle gag-asp_proteas PF13975.6 CDW59346.1 - 0.0046 17.5 0.0 0.012 16.2 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Retrotrans_gag PF03732.17 CDW59346.1 - 0.0052 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC_4 PF14392.6 CDW59346.1 - 0.0093 15.7 6.1 0.19 11.5 1.0 2.5 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.6 CDW59346.1 - 0.055 14.1 0.0 0.17 12.5 0.0 1.8 2 0 0 2 2 2 0 Aspartyl protease zf-CCHC_6 PF15288.6 CDW59346.1 - 1.3 8.9 12.5 0.62 9.9 3.0 2.6 1 1 1 2 2 2 0 Zinc knuckle ABC_membrane PF00664.23 CDW59347.1 - 2.2e-76 257.1 26.8 2.3e-44 152.1 6.8 2.7 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDW59347.1 - 1.8e-54 184.0 0.0 2.3e-27 96.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDW59347.1 - 1.2e-07 31.4 5.5 0.064 12.7 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDW59347.1 - 9.5e-07 29.4 0.0 0.016 15.6 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CDW59347.1 - 1.1e-06 28.7 0.6 0.024 14.7 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW59347.1 - 1.7e-05 24.8 1.7 0.013 15.4 0.5 2.6 2 1 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 CDW59347.1 - 9.2e-05 22.4 0.4 0.39 10.5 0.2 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW59347.1 - 0.00011 21.8 1.5 0.34 10.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CDW59347.1 - 0.00017 20.9 0.4 0.076 12.3 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_23 PF13476.6 CDW59347.1 - 0.00021 21.9 2.7 0.16 12.5 0.0 2.7 3 0 0 3 3 2 2 AAA domain DUF87 PF01935.17 CDW59347.1 - 0.0011 19.1 3.3 0.17 11.9 0.2 3.1 3 0 0 3 3 3 1 Helicase HerA, central domain T2SSE PF00437.20 CDW59347.1 - 0.0027 16.8 1.0 0.21 10.6 0.0 3.0 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_30 PF13604.6 CDW59347.1 - 0.0043 16.8 0.7 3.9 7.2 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 CDW59347.1 - 0.0053 17.0 0.9 5.1 7.4 0.1 3.3 3 0 0 3 3 3 1 AAA domain TsaE PF02367.17 CDW59347.1 - 0.0095 15.9 0.1 2.2 8.3 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CDW59347.1 - 0.014 15.6 0.4 7.7 6.8 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CDW59347.1 - 0.017 15.2 4.8 0.35 10.9 1.0 2.7 2 0 0 2 2 2 0 Dynamin family NB-ARC PF00931.22 CDW59347.1 - 0.019 14.2 1.6 0.71 9.0 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_15 PF13175.6 CDW59347.1 - 0.02 14.6 0.1 2.6 7.7 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain PduV-EutP PF10662.9 CDW59347.1 - 0.025 14.3 1.0 5.3 6.8 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 CDW59347.1 - 0.034 13.7 1.2 0.2 11.3 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 CDW59347.1 - 0.039 13.4 0.3 3.6 7.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 CDW59347.1 - 0.042 13.8 0.6 0.91 9.4 0.1 2.6 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.13 CDW59347.1 - 0.046 12.9 0.4 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 CDW59347.1 - 0.051 13.3 0.4 2.7 7.7 0.1 2.6 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CDW59347.1 - 0.053 12.9 0.1 1.3 8.3 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.25 CDW59347.1 - 0.056 13.1 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain TrwB_AAD_bind PF10412.9 CDW59347.1 - 0.11 11.4 2.1 8.8 5.1 0.1 2.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain MobB PF03205.14 CDW59347.1 - 0.11 12.3 1.4 1.6 8.6 0.2 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.27 CDW59347.1 - 0.17 11.4 0.0 8.6 5.8 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_25 PF13481.6 CDW59347.1 - 0.18 11.4 0.6 4.4 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 CDW59347.1 - 0.31 10.8 2.2 22 4.8 1.4 3.0 2 1 0 2 2 2 0 DEAD/DEAH box helicase ATP_bind_1 PF03029.17 CDW59347.1 - 1.9 8.2 5.1 33 4.1 0.0 3.2 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Oleosin PF01277.17 CDW59347.1 - 3.3 7.5 10.4 3.4 7.5 0.3 3.2 2 0 0 2 2 2 0 Oleosin AAA PF00004.29 CDW59348.1 - 3.1e-41 140.9 0.0 4.3e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CDW59348.1 - 3.5e-06 27.3 0.1 0.0026 18.1 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 CDW59348.1 - 2.8e-05 24.2 0.1 0.00077 19.5 0.1 2.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDW59348.1 - 6.1e-05 23.2 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CDW59348.1 - 0.00016 22.1 0.0 0.011 16.1 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 CDW59348.1 - 0.0017 17.5 0.0 0.0025 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 CDW59348.1 - 0.0037 17.0 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CDW59348.1 - 0.0088 16.2 0.0 0.014 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDW59348.1 - 0.0093 15.4 0.1 0.023 14.1 0.1 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CDW59348.1 - 0.012 15.4 0.0 0.033 13.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CDW59348.1 - 0.014 15.7 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CDW59348.1 - 0.024 14.5 0.0 0.042 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CDW59348.1 - 0.025 15.2 0.0 0.041 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDW59348.1 - 0.043 13.3 0.0 0.096 12.2 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CDW59348.1 - 0.05 13.5 0.0 1.6 8.6 0.0 2.2 1 1 1 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 CDW59348.1 - 0.051 13.3 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 CDW59348.1 - 0.057 13.8 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Sigma54_activ_2 PF14532.6 CDW59348.1 - 0.061 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.13 CDW59348.1 - 0.07 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_30 PF13604.6 CDW59348.1 - 0.075 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDW59348.1 - 0.089 12.4 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CDW59348.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CDW59348.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 CDW59348.1 - 0.16 11.0 0.1 0.3 10.1 0.1 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Histone PF00125.24 CDW59349.1 - 7.3e-11 42.5 0.8 8.6e-11 42.3 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59349.1 - 0.0013 19.0 0.0 0.0024 18.1 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CDW59349.1 - 0.0061 17.0 0.1 0.012 16.1 0.1 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-T_C PF15511.6 CDW59349.1 - 0.049 13.7 0.1 0.18 11.9 0.1 1.8 1 1 1 2 2 2 0 Centromere kinetochore component CENP-T histone fold RVT_1 PF00078.27 CDW59351.1 - 2.5e-07 30.4 0.0 4.3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CH PF00307.31 CDW59352.1 - 1.3e-15 57.5 0.1 9.5e-08 32.2 0.0 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain ASH PF15780.5 CDW59352.1 - 9.2e-07 29.0 0.0 3.3e-06 27.2 0.0 2.0 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin CAMSAP_CH PF11971.8 CDW59352.1 - 3.5e-05 23.6 0.1 0.002 17.9 0.1 2.6 2 0 0 2 2 2 1 CAMSAP CH domain IQ PF00612.27 CDW59352.1 - 0.0046 16.6 31.6 0.012 15.3 3.1 5.4 5 0 0 5 5 5 3 IQ calmodulin-binding motif Motile_Sperm PF00635.26 CDW59352.1 - 0.049 13.5 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Med11 PF10280.9 CDW59353.1 - 2.9e-11 44.0 0.8 3.2e-11 43.9 0.8 1.1 1 0 0 1 1 1 1 Mediator complex protein HSBP1 PF06825.12 CDW59353.1 - 0.12 12.3 0.1 3.6 7.5 0.0 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Ribosomal_L30 PF00327.20 CDW59354.1 - 2.8e-11 43.1 0.3 5.4e-11 42.2 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Glutaredoxin PF00462.24 CDW59355.1 - 9.6e-21 73.8 0.0 2e-20 72.8 0.0 1.5 2 0 0 2 2 2 1 Glutaredoxin Pkinase PF00069.25 CDW59356.1 - 6.5e-27 94.5 0.3 1.3e-12 47.6 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59356.1 - 3.4e-18 65.9 0.2 1.1e-11 44.6 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 CDW59357.1 - 9.7e-35 120.2 0.0 1.7e-34 119.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59357.1 - 3.5e-18 65.8 0.0 1e-17 64.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CDW59357.1 - 0.0056 16.6 0.1 0.0095 15.9 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CDW59357.1 - 0.053 12.8 0.0 0.13 11.5 0.0 1.7 1 1 0 1 1 1 0 Kinase-like Nnf1 PF03980.14 CDW59358.1 - 0.00053 20.4 0.5 0.00077 19.8 0.5 1.3 1 0 0 1 1 1 1 Nnf1 ADIP PF11559.8 CDW59358.1 - 0.0047 17.0 1.4 0.0065 16.6 1.4 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding V-SNARE PF05008.15 CDW59358.1 - 0.0096 16.3 0.2 0.019 15.3 0.2 1.5 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus bZIP_1 PF00170.21 CDW59358.1 - 0.015 15.4 0.4 0.035 14.2 0.4 1.7 1 0 0 1 1 1 0 bZIP transcription factor LSM PF01423.22 CDW59359.1 - 5.2e-06 26.0 0.0 1e-05 25.1 0.0 1.5 1 1 0 1 1 1 1 LSM domain FAS_I_H PF18314.1 CDW59359.1 - 0.043 13.4 0.0 0.085 12.5 0.0 1.6 1 0 0 1 1 1 0 Fatty acid synthase type I helical domain COX4 PF02936.14 CDW59361.1 - 2e-47 160.7 0.0 2.4e-47 160.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV PH_16 PF17838.1 CDW59362.1 - 2.4e-30 104.9 0.0 8e-30 103.2 0.0 2.0 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 CDW59362.1 - 1.8e-21 77.2 5.5 1.8e-21 77.2 5.5 2.3 2 0 0 2 2 2 1 RhoGEF domain C1_2 PF03107.16 CDW59362.1 - 0.00033 20.9 5.8 0.00079 19.7 5.8 1.6 1 0 0 1 1 1 1 C1 domain Golgin_A5 PF09787.9 CDW59362.1 - 0.036 13.5 10.0 0.039 13.4 6.8 2.3 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF4407 PF14362.6 CDW59362.1 - 0.042 13.2 3.3 0.11 11.8 3.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PHD PF00628.29 CDW59362.1 - 0.044 13.7 5.7 0.11 12.5 5.7 1.7 1 0 0 1 1 1 0 PHD-finger TolA_bind_tri PF16331.5 CDW59362.1 - 0.13 12.3 3.4 0.96 9.6 0.5 3.6 2 1 1 3 3 3 0 TolA binding protein trimerisation C1_1 PF00130.22 CDW59362.1 - 0.26 11.2 8.2 0.85 9.6 8.2 1.9 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4078 PF13300.6 CDW59362.1 - 1.1 9.6 4.8 1.3 9.4 3.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4078) DNA_pol_E_B PF04042.16 CDW59363.1 - 1e-24 87.1 0.3 1.5e-24 86.6 0.3 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 CDW59363.1 - 0.032 14.2 0.3 0.066 13.2 0.0 1.6 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Tnp_zf-ribbon_2 PF13842.6 CDW59363.1 - 0.58 11.0 3.0 1.4 9.8 3.0 1.6 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon Golgin_A5 PF09787.9 CDW59364.1 - 0.0021 17.6 24.4 0.0021 17.6 24.4 2.5 1 1 1 2 2 2 1 Golgin subfamily A member 5 Prominin PF05478.11 CDW59364.1 - 1.7 6.5 30.4 0.35 8.8 1.8 2.7 1 1 1 3 3 3 0 Prominin RPW8 PF05659.11 CDW59364.1 - 2 8.1 24.8 0.32 10.7 2.9 4.2 2 2 2 4 4 4 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF2779 PF11074.8 CDW59364.1 - 3.3 8.2 14.9 2 8.9 4.2 2.8 1 1 0 2 2 2 0 Domain of unknown function(DUF2779) TetR_C_6 PF13977.6 CDW59364.1 - 6.5 7.0 6.5 1.2 9.4 0.6 2.5 3 0 0 3 3 3 0 BetI-type transcriptional repressor, C-terminal Calponin PF00402.18 CDW59365.1 - 0.0015 18.1 1.9 0.0015 18.1 1.9 4.1 4 0 0 4 4 4 2 Calponin family repeat WD40 PF00400.32 CDW59366.1 - 2.1e-09 37.8 6.8 0.059 14.3 0.0 6.5 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW59366.1 - 9e-09 35.5 0.3 0.0087 16.3 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 CDW59366.1 - 0.0082 15.2 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain Phospholip_A2_1 PF00068.19 CDW59368.1 - 1.5e-24 86.6 13.4 2e-24 86.2 13.4 1.3 1 0 0 1 1 1 1 Phospholipase A2 Parvo_coat_N PF08398.10 CDW59368.1 - 0.0081 16.3 0.0 0.013 15.7 0.0 1.2 1 0 0 1 1 1 1 Parvovirus coat protein VP1 Phospholip_A2_2 PF05826.12 CDW59368.1 - 0.12 12.6 15.6 4.3 7.6 15.6 2.4 1 1 0 1 1 1 0 Phospholipase A2 SNase PF00565.17 CDW59371.1 - 1.7e-25 89.6 0.0 3.1e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Staphylococcal nuclease homologue HTH_Tnp_1 PF01527.20 CDW59371.1 - 6.8e-06 26.3 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Transposase YolD PF08863.10 CDW59371.1 - 0.17 11.9 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 YolD-like protein FinO_N PF12602.8 CDW59372.1 - 3.8e-35 120.0 11.4 7.6e-35 119.0 11.4 1.5 1 0 0 1 1 1 1 Fertility inhibition protein N terminal ProQ PF04352.13 CDW59372.1 - 2.7e-25 88.4 0.4 2.4e-24 85.4 0.0 2.0 1 1 1 2 2 2 1 ProQ/FINO family Thump_like PF18096.1 CDW59372.1 - 0.024 14.6 0.1 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 THUMP domain-like TraX PF05857.11 CDW59373.1 - 5.9e-50 170.3 7.1 6.6e-50 170.2 7.1 1.0 1 0 0 1 1 1 1 TraX protein TrwC PF08751.11 CDW59374.1 - 1.1e-75 254.9 0.7 3.1e-75 253.5 0.7 1.8 1 0 0 1 1 1 1 TrwC relaxase TraI PF07057.11 CDW59374.1 - 3.8e-60 201.4 0.0 1.6e-59 199.4 0.0 2.2 2 0 0 2 2 2 1 DNA helicase TraI AAA_30 PF13604.6 CDW59374.1 - 4e-37 127.8 13.2 2.4e-34 118.7 2.4 2.9 2 0 0 2 2 2 2 AAA domain TraI_2B PF18340.1 CDW59374.1 - 2.7e-30 104.3 1.8 4.8e-30 103.5 0.5 2.2 2 0 0 2 2 2 1 DNA relaxase TraI 2B/2B-like domain ssDNA_TraI_N PF18272.1 CDW59374.1 - 7.3e-29 99.5 7.0 1.7e-28 98.4 0.6 4.0 3 0 0 3 3 3 1 single-stranded DNA binding TraI N-terminal subdomain AAA_19 PF13245.6 CDW59374.1 - 1.5e-09 38.4 0.5 1e-08 35.6 0.1 2.5 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 CDW59374.1 - 0.15 11.9 0.1 0.55 10.1 0.1 2.1 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 CDW59374.1 - 0.15 11.8 5.6 0.16 11.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain Viral_helicase1 PF01443.18 CDW59374.1 - 0.17 11.6 0.0 5.8 6.6 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MazE_antitoxin PF04014.18 CDW59375.1 - 2e-06 27.6 0.3 3.1e-06 27.0 0.3 1.3 1 1 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin PIN PF01850.21 CDW59376.1 - 3.4e-11 43.7 0.0 3.7e-11 43.6 0.0 1.0 1 0 0 1 1 1 1 PIN domain DUF5615 PF18480.1 CDW59376.1 - 0.069 12.9 0.0 0.081 12.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) TrwB_AAD_bind PF10412.9 CDW59377.1 - 2.4e-121 405.3 0.0 3e-121 405.0 0.0 1.1 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain TraD_N PF12615.8 CDW59377.1 - 8.6e-32 109.8 10.3 2.5e-29 101.9 11.1 2.3 2 0 0 2 2 2 1 F sex factor protein N terminal TraG-D_C PF12696.7 CDW59377.1 - 1.4e-19 70.3 0.0 2.5e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 TraM recognition site of TraD and TraG T4SS-DNA_transf PF02534.14 CDW59377.1 - 1.1e-07 31.0 0.0 3.4e-07 29.4 0.0 1.8 1 1 0 1 1 1 1 Type IV secretory system Conjugative DNA transfer AAA_16 PF13191.6 CDW59377.1 - 0.0012 19.3 0.0 0.0093 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 CDW59377.1 - 0.043 13.1 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_10 PF12846.7 CDW59377.1 - 0.066 12.1 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.6 CDW59377.1 - 0.082 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2207 PF09972.9 CDW59377.1 - 0.3 9.8 1.7 0.59 8.8 1.7 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TraG_N PF07916.11 CDW59378.1 - 3.2e-100 336.2 10.3 3.2e-100 336.2 10.3 3.1 3 0 0 3 3 3 2 TraG-like protein, N-terminal region TraH PF06122.11 CDW59379.1 - 3e-113 378.8 2.4 4.4e-113 378.2 2.4 1.2 1 0 0 1 1 1 1 Conjugative relaxosome accessory transposon protein TraF PF13728.6 CDW59379.1 - 1.5e-11 44.6 0.1 3.6e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 F plasmid transfer operon protein DSBA PF01323.20 CDW59379.1 - 0.0014 18.4 0.1 0.0044 16.8 0.0 1.9 2 0 0 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 CDW59379.1 - 0.0021 18.5 0.0 0.0057 17.1 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain PepSY_TM PF03929.16 CDW59379.1 - 0.026 14.2 0.0 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 PepSY-associated TM region Thioredoxin PF00085.20 CDW59379.1 - 0.058 13.4 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin DUF3480 PF11979.8 CDW59379.1 - 0.084 11.8 1.4 0.14 11.1 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3480) TFIID-31kDa PF02291.15 CDW59379.1 - 0.14 12.2 1.0 7.8 6.6 0.0 2.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Thioredoxin_4 PF13462.6 CDW59379.1 - 0.19 11.9 1.1 0.5 10.5 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin TraN PF06986.11 CDW59380.1 - 1.7e-80 270.2 20.4 1.7e-80 270.2 20.4 1.5 2 0 0 2 2 2 1 Type-1V conjugative transfer system mating pair stabilisation TraF PF13728.6 CDW59380.1 - 7.8e-66 222.1 0.4 1.2e-65 221.5 0.4 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Tir_receptor_M PF03549.14 CDW59380.1 - 0.12 12.7 0.0 0.35 11.2 0.0 1.8 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) intimin-binding domain TrbC_Ftype PF09673.10 CDW59381.1 - 2.6e-20 72.5 0.0 7.8e-20 71.0 0.0 1.7 1 1 0 1 1 1 1 Type-F conjugative transfer system pilin assembly protein RRM_1 PF00076.22 CDW59382.1 - 1.9e-17 62.8 0.0 2.3e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CDW59382.1 - 0.056 13.3 0.0 0.073 12.9 0.0 1.1 1 0 0 1 1 1 0 Occluded RNA-recognition motif SET_assoc PF11767.8 CDW59382.1 - 0.13 11.9 0.1 0.18 11.5 0.1 1.2 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_5 PF13893.6 CDW59382.1 - 0.14 11.8 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GTP_EFTU PF00009.27 CDW59383.1 - 2.6e-20 72.8 0.0 6.3e-20 71.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CDW59383.1 - 6.5e-08 32.9 0.1 2.8e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 CDW59383.1 - 4.8e-06 26.8 0.1 1.4e-05 25.4 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 CDW59383.1 - 0.00044 20.3 0.1 0.0014 18.7 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 CDW59383.1 - 0.014 15.2 0.0 3.4 7.4 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 CDW59383.1 - 0.083 12.4 0.0 0.34 10.4 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.23 CDW59383.1 - 0.13 12.4 0.1 0.25 11.4 0.1 1.6 1 1 0 1 1 1 0 Dynamin family Adaptin_N PF01602.20 CDW59385.1 - 3.8e-64 217.1 0.0 4.4e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CDW59385.1 - 2.4e-11 44.0 0.0 2.5e-09 37.4 0.0 2.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDW59385.1 - 5.5e-06 26.7 0.0 0.0071 16.7 0.0 2.7 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 CDW59385.1 - 0.00053 20.0 0.0 2 8.9 0.0 3.9 4 0 0 4 4 4 1 HEAT repeat RTP1_C1 PF10363.9 CDW59385.1 - 0.0016 18.6 0.0 0.031 14.5 0.0 2.3 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 DGCR6 PF07324.11 CDW59386.1 - 6.3e-14 52.1 8.6 8.9e-14 51.6 8.6 1.2 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein HSBP1 PF06825.12 CDW59386.1 - 6e-06 26.0 7.4 0.0064 16.3 0.1 2.7 2 0 0 2 2 2 2 Heat shock factor binding protein 1 Ly49 PF08391.10 CDW59386.1 - 3.8 7.9 6.0 1.1 9.7 2.9 1.8 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region Oxidored_q2 PF00420.24 CDW59387.1 - 0.12 12.1 3.9 0.18 11.4 2.8 1.9 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Cpn60_TCP1 PF00118.24 CDW59388.1 - 1.2e-87 294.6 17.9 2.1e-87 293.8 17.9 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3388 PF11868.8 CDW59388.1 - 0.09 12.1 0.1 0.24 10.7 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3388) Umbravirus_LDM PF04817.12 CDW59388.1 - 0.12 11.7 1.2 0.68 9.3 0.1 2.2 2 0 0 2 2 2 0 Umbravirus long distance movement (LDM) family ENTH PF01417.20 CDW59389.1 - 5.2e-44 149.3 0.8 1.2e-43 148.1 0.2 1.8 2 0 0 2 2 2 1 ENTH domain ANTH PF07651.16 CDW59389.1 - 1.9e-07 30.4 0.2 5.7e-07 28.8 0.0 1.9 2 1 0 2 2 2 1 ANTH domain VHS PF00790.19 CDW59389.1 - 0.00096 19.0 0.1 0.0016 18.3 0.1 1.4 1 1 0 1 1 1 1 VHS domain RTBV_P46 PF06216.11 CDW59389.1 - 0.26 10.2 3.2 0.13 11.1 0.9 1.6 2 0 0 2 2 2 0 Rice tungro bacilliform virus P46 protein 3Beta_HSD PF01073.19 CDW59390.1 - 3.5e-40 137.8 0.0 4.9e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDW59390.1 - 9.1e-12 45.0 0.0 1.2e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CDW59390.1 - 5.1e-06 25.8 0.0 7.5e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CDW59390.1 - 0.0023 17.1 0.0 0.067 12.3 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 CDW59390.1 - 0.062 12.4 0.0 0.48 9.5 0.0 2.0 1 1 0 1 1 1 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CDW59390.1 - 0.069 12.5 0.0 2.7 7.3 0.0 2.2 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Mob1_phocein PF03637.17 CDW59391.1 - 1.1e-34 119.9 0.8 1.6e-34 119.4 0.8 1.2 1 0 0 1 1 1 1 Mob1/phocein family Cys_rich_VLP PF14194.6 CDW59391.1 - 0.21 11.8 2.5 0.37 10.9 1.6 2.0 1 1 0 1 1 1 0 Cysteine-rich VLP preSET_CXC PF18264.1 CDW59391.1 - 0.45 11.0 3.7 1.1 9.8 0.7 2.7 3 0 0 3 3 3 0 CXC domain Arf PF00025.21 CDW59393.1 - 1.5e-76 255.7 0.0 2.2e-76 255.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW59393.1 - 1.4e-12 47.8 0.0 2.8e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CDW59393.1 - 1.5e-11 44.1 0.0 2.2e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Thioredoxin PF00085.20 CDW59393.1 - 2.7e-11 43.3 0.0 8.1e-05 22.5 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin Ras PF00071.22 CDW59393.1 - 5.9e-11 42.2 0.0 1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CDW59393.1 - 8.1e-10 38.4 0.9 2e-06 27.2 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 CDW59393.1 - 1.2e-08 34.6 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Thioredoxin_6 PF13848.6 CDW59393.1 - 0.00022 21.2 0.0 1.2 9.0 0.0 4.1 4 0 0 4 4 4 1 Thioredoxin-like domain MMR_HSR1 PF01926.23 CDW59393.1 - 0.00074 19.6 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CDW59393.1 - 0.08 12.2 0.1 0.17 11.1 0.1 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Atthog PF18800.1 CDW59393.1 - 0.11 12.5 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Attenuator of Hedgehog LRR_4 PF12799.7 CDW59394.1 - 0.00021 21.6 11.6 0.055 13.9 0.3 4.5 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDW59394.1 - 0.078 12.8 9.3 0.47 10.3 2.8 4.0 3 1 0 3 3 3 0 Leucine rich repeat Arm PF00514.23 CDW59395.1 - 1.2 9.3 6.0 34 4.7 0.1 4.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HSP70 PF00012.20 CDW59396.1 - 2.3e-168 561.1 0.0 3.1e-168 560.7 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDW59396.1 - 7e-06 25.1 0.0 1.6e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 MreB/Mbl protein RVP_2 PF08284.11 CDW59396.1 - 0.021 14.6 0.0 0.063 13.0 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease CHAD PF05235.14 CDW59396.1 - 0.054 13.5 2.6 0.13 12.2 2.6 1.6 1 0 0 1 1 1 0 CHAD domain 7TMR-HDED PF07697.11 CDW59396.1 - 1.1 9.3 4.8 1.1 9.3 3.0 1.9 3 0 0 3 3 3 0 7TM-HD extracellular PALP PF00291.25 CDW59397.1 - 1.2e-67 228.4 0.0 1.4e-67 228.2 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CPSase_L_D2 PF02786.17 CDW59398.1 - 1.4e-97 325.3 0.1 2.2e-67 226.6 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 CDW59398.1 - 1.9e-46 157.1 0.0 3.9e-46 156.0 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 CDW59398.1 - 1.3e-44 152.2 0.0 2.4e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 CDW59398.1 - 5.7e-40 136.7 0.3 4e-39 134.0 0.0 2.3 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 CDW59398.1 - 1.6e-34 118.9 0.0 3.9e-34 117.6 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 CDW59398.1 - 3.5e-31 108.4 0.3 1.4e-30 106.5 0.1 2.1 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 CDW59398.1 - 2.2e-16 59.8 0.0 6.4e-16 58.3 0.0 1.9 1 0 0 1 1 1 1 MGS-like domain ATPgrasp_Ter PF15632.6 CDW59398.1 - 4.5e-12 45.9 0.0 4.7e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 CDW59398.1 - 8.9e-12 45.0 0.2 6.4e-07 29.1 0.1 2.6 2 1 0 2 2 2 2 D-ala D-ala ligase C-terminus Amidohydro_1 PF01979.20 CDW59398.1 - 1.5e-11 44.2 0.0 3.2e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family ATP-grasp PF02222.22 CDW59398.1 - 8.3e-11 41.8 0.1 2e-08 34.0 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain Peptidase_C26 PF07722.13 CDW59398.1 - 9.4e-07 28.8 0.1 0.00015 21.6 0.1 3.0 2 1 0 2 2 2 1 Peptidase C26 ATP-grasp_3 PF02655.14 CDW59398.1 - 6.4e-05 23.0 0.2 0.0095 16.0 0.0 2.6 2 0 0 2 2 2 1 ATP-grasp domain DJ-1_PfpI PF01965.24 CDW59398.1 - 0.0061 16.4 0.0 1.5 8.6 0.0 3.2 3 0 0 3 3 3 1 DJ-1/PfpI family Bud13 PF09736.9 CDW59399.1 - 1e-32 113.5 3.4 1e-32 113.5 3.4 2.0 1 1 1 2 2 2 1 Pre-mRNA-splicing factor of RES complex DUF4659 PF15558.6 CDW59399.1 - 0.012 14.5 11.6 0.022 13.7 11.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4659) DUF4047 PF13256.6 CDW59399.1 - 0.094 12.9 1.2 0.17 12.0 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) PI31_Prot_C PF08577.11 CDW59399.1 - 0.23 12.6 0.1 0.23 12.6 0.1 2.7 2 1 0 2 2 2 0 PI31 proteasome regulator PA26 PF04636.13 CDW59399.1 - 0.47 9.3 4.1 0.7 8.7 4.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CytochromB561_N PF09786.9 CDW59399.1 - 4.8 6.1 15.2 1.6 7.6 12.7 1.3 1 1 0 1 1 1 0 Cytochrome B561, N terminal GST_C PF00043.25 CDW59400.1 - 3.1e-06 27.3 0.0 7e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CDW59400.1 - 2.2e-05 24.6 0.2 0.0001 22.4 0.0 2.0 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CDW59400.1 - 0.00024 21.1 0.0 0.00046 20.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DUF1244 PF06844.11 CDW59400.1 - 0.0018 18.4 0.1 0.0049 17.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1244) Glutaredoxin2_C PF04399.13 CDW59400.1 - 0.0031 17.3 0.0 0.0063 16.4 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin 2, C terminal domain GST_C_6 PF17171.4 CDW59400.1 - 0.047 13.5 0.0 0.094 12.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RIIa PF02197.17 CDW59402.1 - 0.00092 18.8 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Dpy-30 PF05186.13 CDW59402.1 - 0.0055 16.4 0.0 0.0085 15.8 0.0 1.3 1 0 0 1 1 1 1 Dpy-30 motif DUF5582 PF17819.1 CDW59402.1 - 0.026 15.0 0.0 0.04 14.4 0.0 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5582) DUF5586 PF17824.1 CDW59402.1 - 0.1 11.7 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5586) STb_secrete PF09075.10 CDW59403.1 - 0.76 9.9 14.3 1.2 9.3 0.0 3.9 3 1 1 4 4 4 0 Heat-stable enterotoxin B, secretory DUF4668 PF15701.5 CDW59403.1 - 0.89 9.4 2.8 1.5 8.6 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) Keratin_2_head PF16208.5 CDW59403.1 - 2.6 8.2 12.6 4.6 7.4 12.6 1.4 1 0 0 1 1 1 0 Keratin type II head Cytochrom_B_C PF00032.17 CDW59404.1 - 4.4 7.6 10.6 13 6.1 4.0 3.3 3 1 1 4 4 4 0 Cytochrome b(C-terminal)/b6/petD Peptidase_C92 PF05708.12 CDW59405.1 - 3.7e-08 33.6 0.0 5.2e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Bromodomain PF00439.25 CDW59406.1 - 3.3e-07 30.3 0.0 5.9e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Bromodomain zf-HC5HC2H PF13771.6 CDW59406.1 - 0.029 14.6 3.0 0.069 13.4 3.0 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD PF00628.29 CDW59406.1 - 1.5 8.8 10.7 0.32 10.9 6.5 2.2 2 1 0 2 2 2 0 PHD-finger AAA PF00004.29 CDW59408.1 - 4.1e-44 150.2 0.0 8.6e-44 149.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW59408.1 - 8.3e-12 44.7 0.2 8.3e-12 44.7 0.2 1.9 2 0 0 2 2 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CDW59408.1 - 3.3e-08 33.4 0.5 6.8e-08 32.4 0.0 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 CDW59408.1 - 2.1e-07 31.5 0.1 7.2e-05 23.2 0.0 2.7 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 CDW59408.1 - 6.1e-07 29.5 0.1 4.3e-05 23.5 0.0 3.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDW59408.1 - 6e-06 26.6 0.1 0.0024 18.2 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 CDW59408.1 - 1.3e-05 25.4 0.0 5.3e-05 23.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CDW59408.1 - 1.5e-05 24.8 0.0 3.3e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CDW59408.1 - 0.00021 21.8 0.2 0.0019 18.8 0.0 2.4 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 CDW59408.1 - 0.00026 20.8 0.1 0.014 15.1 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CDW59408.1 - 0.00039 20.6 0.3 0.0022 18.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 CDW59408.1 - 0.00072 19.3 0.1 0.66 9.6 0.0 2.4 2 0 0 2 2 2 2 Thymidylate kinase AAA_7 PF12775.7 CDW59408.1 - 0.0013 18.3 0.0 0.0031 17.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_11 PF13086.6 CDW59408.1 - 0.0024 17.7 0.4 0.17 11.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 CDW59408.1 - 0.0037 17.2 0.0 0.0085 16.1 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 CDW59408.1 - 0.0049 16.7 0.0 0.015 15.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 CDW59408.1 - 0.0049 16.1 2.0 0.0088 15.3 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 CDW59408.1 - 0.0051 17.2 0.0 0.014 15.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase DUF815 PF05673.13 CDW59408.1 - 0.0053 16.0 0.0 0.013 14.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CDW59408.1 - 0.0065 16.2 0.3 0.015 15.1 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 CDW59408.1 - 0.007 16.4 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDW59408.1 - 0.013 14.8 0.0 0.031 13.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 CDW59408.1 - 0.017 15.0 0.9 0.5 10.2 0.0 3.1 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea DUF5105 PF17118.5 CDW59408.1 - 0.036 13.9 3.0 0.068 13.0 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5105) AAA_28 PF13521.6 CDW59408.1 - 0.057 13.7 0.0 0.21 11.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 CDW59408.1 - 0.068 13.3 0.5 0.51 10.4 0.0 2.5 2 1 1 3 3 3 0 Shikimate kinase Prot_ATP_OB_N PF17758.1 CDW59408.1 - 0.078 12.6 0.3 0.26 11.0 0.1 1.9 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain CALM_bind PF16025.5 CDW59408.1 - 0.096 13.2 2.0 0.22 12.0 2.0 1.5 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding NACHT PF05729.12 CDW59408.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.7 1 1 0 1 1 1 0 NACHT domain DUF1822 PF08852.11 CDW59408.1 - 0.13 11.3 0.2 0.19 10.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1822) Parvo_NS1 PF01057.17 CDW59408.1 - 0.15 11.1 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TMIE PF16038.5 CDW59409.1 - 5.2e-20 71.1 3.0 7.5e-20 70.6 3.0 1.2 1 0 0 1 1 1 1 TMIE protein TMEM154 PF15102.6 CDW59409.1 - 0.048 13.6 0.2 0.051 13.5 0.2 1.2 1 0 0 1 1 1 0 TMEM154 protein family Shisa PF13908.6 CDW59409.1 - 0.048 13.9 0.0 0.049 13.9 0.0 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Comm PF15957.5 CDW59409.1 - 0.062 13.6 0.2 0.082 13.3 0.2 1.2 1 0 0 1 1 1 0 Commissureless LptF_LptG PF03739.14 CDW59409.1 - 0.081 11.8 0.0 0.09 11.6 0.0 1.0 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Orthoreo_P10 PF07204.11 CDW59409.1 - 0.12 12.3 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 UPF0047 PF01894.17 CDW59410.1 - 1.1e-35 122.3 0.0 1.3e-35 122.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 UTP25 PF06862.12 CDW59411.1 - 1.1e-160 535.6 1.2 1.3e-160 535.3 1.2 1.0 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 CDW59411.1 - 0.13 12.0 0.0 0.5 10.1 0.0 2.0 3 0 0 3 3 3 0 DEAD/DEAH box helicase WBS_methylT PF12589.8 CDW59412.1 - 2.3e-17 63.5 1.6 4.7e-17 62.5 1.6 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CDW59412.1 - 2.5e-10 40.8 0.0 4.5e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW59412.1 - 3.3e-09 37.3 0.0 6.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW59412.1 - 0.00082 19.2 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW59412.1 - 0.0018 19.0 0.1 0.007 17.1 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW59412.1 - 0.0034 17.2 0.1 0.0073 16.1 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 CDW59412.1 - 0.0092 16.3 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 CDW59412.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain N6_N4_Mtase PF01555.18 CDW59412.1 - 0.025 14.3 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 DNA methylase PCMT PF01135.19 CDW59412.1 - 0.077 12.7 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Amino_oxidase PF01593.24 CDW59412.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase zf-rbx1 PF12678.7 CDW59413.1 - 1.7e-08 34.6 3.6 5e-08 33.1 3.6 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CDW59413.1 - 1.7e-08 34.6 4.6 5.1e-08 33.1 4.6 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW59413.1 - 1.3e-06 28.1 4.2 3.7e-06 26.7 4.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW59413.1 - 3.5e-05 23.6 3.2 3.5e-05 23.6 3.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Tektin PF03148.14 CDW59413.1 - 4.7e-05 22.3 1.8 4.7e-05 22.3 1.8 2.2 1 1 1 2 2 2 1 Tektin family zf-RING_11 PF17123.5 CDW59413.1 - 0.0012 18.6 0.5 0.0012 18.6 0.5 2.3 2 0 0 2 2 2 1 RING-like zinc finger LPP PF04728.13 CDW59413.1 - 0.0044 17.4 1.9 0.66 10.4 0.6 2.9 2 0 0 2 2 2 1 Lipoprotein leucine-zipper zf-RING_5 PF14634.6 CDW59413.1 - 0.011 15.7 5.5 0.033 14.1 5.5 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDW59413.1 - 0.021 14.9 6.3 0.054 13.5 6.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 CDW59413.1 - 0.024 14.7 4.4 0.049 13.7 4.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger THOC7 PF05615.13 CDW59413.1 - 0.038 14.3 2.2 0.038 14.3 2.2 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 TSC22 PF01166.18 CDW59413.1 - 0.04 14.2 7.7 2.2 8.7 0.1 3.9 3 1 1 4 4 4 0 TSC-22/dip/bun family Zn_ribbon_17 PF17120.5 CDW59413.1 - 0.043 13.4 8.1 0.11 12.1 8.1 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type GAS PF13851.6 CDW59413.1 - 0.074 12.4 16.4 0.88 8.9 0.9 2.5 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding zf-C3HC4_3 PF13920.6 CDW59413.1 - 0.093 12.6 9.2 0.25 11.3 9.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Phage_GP20 PF06810.11 CDW59413.1 - 0.096 12.5 9.8 0.15 11.9 9.2 1.6 1 1 0 1 1 1 0 Phage minor structural protein GP20 FlaC_arch PF05377.11 CDW59413.1 - 0.12 12.8 0.3 0.12 12.8 0.3 3.4 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) Syntaxin-6_N PF09177.11 CDW59413.1 - 0.14 12.7 7.0 0.089 13.4 3.9 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DivIC PF04977.15 CDW59413.1 - 0.31 10.8 10.1 0.49 10.2 1.0 3.4 3 0 0 3 3 3 0 Septum formation initiator ADIP PF11559.8 CDW59413.1 - 0.36 10.9 10.7 0.42 10.7 5.9 2.4 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 CDW59413.1 - 0.46 11.0 21.5 0.56 10.7 3.8 3.1 1 1 2 3 3 3 0 Apg6 coiled-coil region KIAA1430 PF13879.6 CDW59413.1 - 0.47 11.2 11.5 1.7 9.4 0.1 2.5 3 0 0 3 3 2 0 KIAA1430 homologue DUF1515 PF07439.11 CDW59413.1 - 0.53 10.3 2.9 2.3 8.3 2.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) Ax_dynein_light PF10211.9 CDW59413.1 - 0.76 9.7 11.3 0.13 12.1 5.3 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain ZapB PF06005.12 CDW59413.1 - 0.77 10.2 14.5 3.7 8.1 0.3 3.4 1 1 1 2 2 2 0 Cell division protein ZapB Snapin_Pallidin PF14712.6 CDW59413.1 - 1.7 9.1 7.8 0.61 10.5 4.4 1.9 2 0 0 2 2 2 0 Snapin/Pallidin CENP-H PF05837.12 CDW59413.1 - 2.2 8.7 13.4 4.5 7.7 5.1 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Med4 PF10018.9 CDW59413.1 - 2.3 7.9 14.8 0.31 10.7 8.0 2.5 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 ABC_tran_CTD PF16326.5 CDW59413.1 - 2.6 8.4 9.9 0.14 12.4 3.0 2.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain FapA PF03961.13 CDW59413.1 - 3.5 6.1 9.4 1.9 7.0 7.3 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A zinc_ribbon_16 PF17034.5 CDW59413.1 - 3.8 7.7 11.8 0.72 10.1 7.1 2.2 2 1 1 3 3 2 0 Zinc-ribbon like family Jnk-SapK_ap_N PF09744.9 CDW59413.1 - 5.4 7.2 18.5 1.2 9.3 8.7 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 GrpE PF01025.19 CDW59413.1 - 8 6.1 12.5 7.7 6.2 8.7 2.6 2 1 1 3 3 3 0 GrpE Cauli_DNA-bind PF03310.13 CDW59413.1 - 9.9 6.3 10.7 3.1 7.9 5.1 2.4 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein CHMI PF02962.15 CDW59414.1 - 0.083 13.2 0.0 0.087 13.2 0.0 1.1 1 0 0 1 1 1 0 5-carboxymethyl-2-hydroxymuconate isomerase YycH PF07435.11 CDW59417.1 - 1.5e-24 86.8 4.9 3e-24 85.8 0.6 2.3 1 1 1 2 2 2 1 YycH protein Lactamase_B_2 PF12706.7 CDW59417.1 - 1e-22 80.7 0.4 1.9e-22 79.8 0.4 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDW59417.1 - 9.1e-21 74.8 1.9 1.3e-20 74.3 1.9 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily YycI PF09648.10 CDW59417.1 - 5.7e-15 55.5 4.6 5.7e-15 55.5 4.6 2.5 2 1 0 2 2 2 1 YycH protein Lactamase_B_3 PF13483.6 CDW59417.1 - 1.8e-07 31.2 0.1 1.6e-06 28.1 0.0 2.4 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CDW59417.1 - 0.00041 19.8 0.0 0.00095 18.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain DUF3787 PF12655.7 CDW59417.1 - 0.056 13.4 0.2 0.13 12.2 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3787) HATPase_c PF02518.26 CDW59418.1 - 4.3e-31 107.7 0.1 1.2e-30 106.3 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDW59418.1 - 4.3e-18 65.1 3.7 6.3e-18 64.6 0.1 3.0 3 1 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDW59418.1 - 7.8e-16 58.2 0.0 2.9e-15 56.4 0.0 2.1 2 0 0 2 2 1 1 HAMP domain PAS PF00989.25 CDW59418.1 - 3.3e-09 36.8 0.6 1.3e-07 31.6 0.1 3.1 2 1 0 2 2 2 1 PAS fold PAS_9 PF13426.7 CDW59418.1 - 8.9e-08 32.3 0.5 3.4e-07 30.5 0.1 2.3 2 1 0 2 2 2 1 PAS domain PAS_4 PF08448.10 CDW59418.1 - 6.8e-06 26.3 0.0 5.8e-05 23.3 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 CDW59418.1 - 2.4e-05 24.2 0.0 8.7e-05 22.4 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS_7 PF12860.7 CDW59418.1 - 8.2e-05 22.7 2.9 0.00058 20.0 0.2 3.2 3 0 0 3 3 3 1 PAS fold HATPase_c_2 PF13581.6 CDW59418.1 - 0.00014 21.8 0.1 0.00042 20.3 0.0 1.8 2 0 0 2 2 1 1 Histidine kinase-like ATPase domain HATPase_c_5 PF14501.6 CDW59418.1 - 0.00045 20.1 0.1 0.0016 18.3 0.1 2.0 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 CDW59418.1 - 0.001 18.9 0.1 0.0027 17.5 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 CDW59418.1 - 0.0022 17.8 0.5 0.0022 17.8 0.5 2.9 3 1 0 3 3 3 1 Cache domain DUF4407 PF14362.6 CDW59418.1 - 0.013 14.9 1.7 0.023 14.0 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WXG100 PF06013.12 CDW59418.1 - 0.031 14.5 1.3 2.7 8.3 0.2 3.0 3 0 0 3 3 2 0 Proteins of 100 residues with WXG Fumerase PF05681.14 CDW59418.1 - 0.049 13.1 0.0 0.087 12.2 0.0 1.3 1 0 0 1 1 1 0 Fumarate hydratase (Fumerase) DUF3347 PF11827.8 CDW59418.1 - 0.14 12.3 1.0 10 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) PHO4 PF01384.20 CDW59418.1 - 0.15 11.1 0.1 0.23 10.5 0.1 1.2 1 0 0 1 1 1 0 Phosphate transporter family Fzo_mitofusin PF04799.13 CDW59418.1 - 0.28 10.7 1.4 0.92 9.0 0.2 2.3 2 0 0 2 2 2 0 fzo-like conserved region Response_reg PF00072.24 CDW59419.1 - 3.3e-29 101.3 0.5 1.6e-28 99.1 0.3 2.2 3 0 0 3 3 3 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDW59419.1 - 3e-27 94.5 0.2 7.1e-27 93.3 0.2 1.6 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal DegV PF02645.16 CDW59419.1 - 1.2e-17 64.1 0.0 2.1e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein, DegV family COG1307 DUF1836 PF08876.11 CDW59419.1 - 5e-05 23.3 0.0 9.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1836) MTD PF01993.18 CDW59419.1 - 0.018 14.4 0.1 0.064 12.6 0.0 1.8 2 0 0 2 2 2 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase SBP_bac_5 PF00496.22 CDW59420.1 - 1.8e-77 260.8 11.9 3e-77 260.2 11.9 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle BPD_transp_1 PF00528.22 CDW59420.1 - 1.6e-69 233.4 44.0 1.1e-39 136.0 12.0 3.9 5 0 0 5 5 5 2 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CDW59420.1 - 2.9e-31 108.8 0.1 2.3e-24 86.5 0.0 3.0 2 1 1 3 3 3 2 ABC transporter oligo_HPY PF08352.12 CDW59420.1 - 9.8e-20 70.9 0.0 5.4e-13 49.3 0.0 2.7 2 0 0 2 2 2 2 Oligopeptide/dipeptide transporter, C-terminal region OppC_N PF12911.7 CDW59420.1 - 2.3e-15 56.3 3.2 1.3e-14 53.9 0.7 3.5 2 0 0 2 2 2 1 N-terminal TM domain of oligopeptide transport permease C AAA_21 PF13304.6 CDW59420.1 - 0.001 18.9 4.1 0.37 10.6 0.3 3.6 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CDW59420.1 - 0.011 16.0 0.5 0.77 10.0 0.1 3.4 3 1 0 3 3 3 0 AAA domain Iso_dh PF00180.20 CDW59421.1 - 6.3e-128 426.8 0.0 1.1e-127 425.9 0.0 1.3 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase HMGL-like PF00682.19 CDW59421.1 - 8.9e-97 323.8 0.5 1.5e-96 323.0 0.5 1.4 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 CDW59421.1 - 8.4e-35 119.6 1.5 2e-34 118.3 1.5 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain UPF0052 PF01933.18 CDW59421.1 - 0.038 13.2 0.2 0.34 10.1 0.1 2.4 3 0 0 3 3 3 0 Uncharacterised protein family UPF0052 Aconitase PF00330.20 CDW59422.1 - 1.1e-127 426.8 0.0 1.3e-127 426.7 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF521 PF04412.13 CDW59422.1 - 0.089 11.5 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Aconitase_C PF00694.19 CDW59423.1 - 2.6e-34 118.4 0.0 3.6e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 CDW59423.1 - 0.14 11.8 0.0 1.4 8.5 0.0 2.0 1 1 0 1 1 1 0 Aconitate hydratase 2 N-terminus ABC_tran PF00005.27 CDW59424.1 - 2.9e-32 112.1 0.0 4.9e-32 111.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 CDW59424.1 - 6.1e-21 75.3 3.6 8.5e-21 74.8 3.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CDW59424.1 - 2e-06 27.4 0.1 2.2e-05 24.0 0.1 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CDW59424.1 - 0.0077 16.0 0.0 0.044 13.5 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 CDW59424.1 - 0.012 15.8 0.8 0.2 11.9 0.8 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 CDW59424.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 CDW59424.1 - 0.06 13.6 0.3 1.1 9.5 0.3 2.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CDW59424.1 - 0.081 13.4 0.9 1 9.8 0.1 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW59424.1 - 0.09 13.1 0.4 0.27 11.6 0.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 CDW59424.1 - 0.11 11.7 0.0 0.9 8.8 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin DUF600 PF04634.12 CDW59425.1 - 0.025 14.6 1.3 0.042 13.9 1.3 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF600 Oscp1 PF10188.9 CDW59425.1 - 0.03 14.4 1.8 1 9.5 0.1 2.1 2 0 0 2 2 2 0 Organic solute transport protein 1 DUF2884 PF11101.8 CDW59425.1 - 0.073 12.6 3.5 0.097 12.2 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) TIR PF01582.20 CDW59425.1 - 0.085 12.7 3.6 0.035 13.9 1.2 1.6 2 0 0 2 2 2 0 TIR domain T4_Rnl2_C PF18043.1 CDW59425.1 - 0.1 12.8 4.5 0.66 10.2 3.2 2.6 1 1 0 1 1 1 0 T4 RNA ligase 2 C-terminal FliG_N PF14842.6 CDW59425.1 - 0.11 13.0 0.9 5.6 7.6 0.1 2.3 1 1 1 2 2 2 0 FliG N-terminal domain JmjN PF02375.17 CDW59425.1 - 0.2 11.7 0.2 0.86 9.6 0.2 2.1 1 0 0 1 1 1 0 jmjN domain NDUF_B6 PF09782.9 CDW59425.1 - 0.41 10.8 3.7 0.63 10.1 3.7 1.3 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit DUF3106 PF11304.8 CDW59425.1 - 0.69 10.4 15.1 1.1 9.7 14.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3106) DUF1104 PF06518.11 CDW59425.1 - 1.9 8.9 10.4 0.59 10.5 3.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1104) CDI PF02234.19 CDW59425.1 - 3.8 7.8 16.6 0.13 12.5 3.1 3.5 2 1 1 3 3 3 0 Cyclin-dependent kinase inhibitor PBECR5 PF18814.1 CDW59425.1 - 6.4 6.6 8.4 11 5.9 8.4 1.3 1 1 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 Exonuc_VII_L PF02601.15 CDW59425.1 - 8.5 5.8 7.4 11 5.5 7.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mur_ligase_M PF08245.12 CDW59426.1 - 3.3e-15 56.6 0.0 5.9e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Mur ligase middle domain HAD_2 PF13419.6 CDW59426.1 - 8.2e-11 42.3 0.2 3.1e-10 40.4 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Mur_ligase_C PF02875.21 CDW59426.1 - 8.8e-05 22.7 0.0 0.00019 21.6 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain tRNA-synt_1 PF00133.22 CDW59427.1 - 4e-226 751.9 5.5 6.3e-224 744.7 5.5 3.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDW59427.1 - 1.4e-45 154.9 0.1 2.5e-45 154.1 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDW59427.1 - 4.8e-29 101.3 1.8 1.6e-16 60.1 2.0 2.9 2 2 0 2 2 2 2 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.9 CDW59427.1 - 2.2e-23 82.3 9.1 6.2e-23 80.9 9.1 1.8 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1_2 PF13603.6 CDW59427.1 - 8.8e-12 44.9 0.2 3.9e-09 36.3 0.0 2.8 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 CDW59427.1 - 1.1e-06 28.2 0.0 3.7e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 CDW59427.1 - 0.0002 20.4 0.0 0.0028 16.6 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (K) CoA_binding PF02629.19 CDW59428.1 - 4.1e-21 75.5 0.0 7.1e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 CoA binding domain Put_DNA-bind_N PF06971.13 CDW59428.1 - 1e-16 60.7 0.2 2.8e-16 59.3 0.1 1.7 2 0 0 2 2 2 1 Putative DNA-binding protein N-terminus GFO_IDH_MocA PF01408.22 CDW59428.1 - 7.1e-07 30.1 0.1 1.1e-06 29.5 0.1 1.2 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 CDW59428.1 - 9.7e-06 26.1 0.1 1.6e-05 25.4 0.1 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PglD_N PF17836.1 CDW59428.1 - 0.0067 17.0 0.0 0.032 14.9 0.0 2.0 2 0 0 2 2 2 1 PglD N-terminal domain Sacchrp_dh_NADP PF03435.18 CDW59428.1 - 0.0075 16.5 0.1 0.023 15.0 0.1 1.9 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 CDW59428.1 - 0.013 15.7 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 CDW59428.1 - 0.052 13.1 0.3 0.26 10.9 0.2 1.9 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HTH_DeoR PF08220.12 CDW59428.1 - 0.052 13.3 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain Toprim_2 PF13155.6 CDW59428.1 - 0.11 13.0 0.0 0.21 12.1 0.0 1.6 1 1 0 1 1 1 0 Toprim-like IlvN PF07991.12 CDW59428.1 - 0.11 12.0 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ThiI PF02568.14 CDW59429.1 - 5.3e-61 205.7 0.0 8e-61 205.1 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) THUMP PF02926.17 CDW59429.1 - 3e-17 63.1 0.0 6.7e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 THUMP domain QueC PF06508.13 CDW59429.1 - 8.4e-07 28.7 0.0 0.00095 18.7 0.0 2.2 2 0 0 2 2 2 2 Queuosine biosynthesis protein QueC NAD_synthase PF02540.17 CDW59429.1 - 0.0013 17.9 0.0 0.0037 16.4 0.0 1.7 2 0 0 2 2 2 1 NAD synthase Put_Phosphatase PF06888.12 CDW59429.1 - 0.011 15.2 0.1 0.84 9.0 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase PAPS_reduct PF01507.19 CDW59429.1 - 0.02 14.9 0.0 0.047 13.7 0.0 1.6 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family tRNA_Me_trans PF03054.16 CDW59429.1 - 0.022 13.5 0.0 0.069 11.9 0.0 1.7 2 0 0 2 2 2 0 tRNA methyl transferase U3_assoc_6 PF08640.11 CDW59429.1 - 0.036 14.1 0.8 0.9 9.7 0.2 2.5 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 ATP_bind_3 PF01171.20 CDW59429.1 - 0.056 13.2 0.0 0.7 9.6 0.0 2.3 2 0 0 2 2 2 0 PP-loop family Cytokin_check_N PF10407.9 CDW59429.1 - 0.12 12.4 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Aminotran_5 PF00266.19 CDW59430.1 - 1.1e-67 228.6 0.4 1.3e-67 228.4 0.4 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CDW59430.1 - 0.013 14.0 0.0 0.016 13.7 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme AvrRpt-cleavage PF05627.11 CDW59430.1 - 0.15 11.5 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Cleavage site for pathogenic type III effector avirulence factor Avr EzrA PF06160.12 CDW59431.1 - 2.7e-174 580.4 46.0 3e-174 580.3 46.0 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4404 PF14357.6 CDW59431.1 - 0.0019 18.8 0.7 0.0019 18.8 0.7 4.7 3 1 0 3 3 3 1 Domain of unknown function (DUF4404) CP12 PF02672.15 CDW59431.1 - 0.0056 17.4 0.3 4 8.2 0.1 3.8 3 0 0 3 3 3 1 CP12 domain Laminin_II PF06009.12 CDW59431.1 - 0.041 13.9 22.7 0.37 10.8 0.8 5.7 4 2 1 5 5 5 0 Laminin Domain II GCK PF07802.11 CDW59431.1 - 0.1 13.0 1.9 0.63 10.5 0.3 3.3 2 1 1 3 3 3 0 GCK domain ANAPC4 PF12896.7 CDW59431.1 - 0.11 12.0 2.4 3.6 7.0 0.1 3.4 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 4 DASH_Dam1 PF08653.10 CDW59431.1 - 0.4 10.5 1.7 13 5.7 0.1 4.3 4 0 0 4 4 4 0 DASH complex subunit Dam1 AAT PF03417.16 CDW59431.1 - 0.5 10.0 3.1 0.44 10.2 0.2 2.2 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase NPV_P10 PF05531.12 CDW59431.1 - 2.5 8.6 12.8 28 5.3 0.4 5.6 3 1 3 6 6 6 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 CDW59431.1 - 3.4 7.9 29.1 1.9 8.7 1.5 5.8 3 2 2 6 6 6 0 Fibrinogen alpha/beta chain family AA_kinase PF00696.28 CDW59432.1 - 4.7e-32 111.5 0.0 1.7e-31 109.7 0.0 1.7 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 CDW59432.1 - 9.3e-08 31.7 0.1 5.1e-05 23.0 0.0 2.5 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 CDW59432.1 - 0.00011 21.9 0.0 0.00049 19.8 0.0 2.0 2 0 0 2 2 2 1 ACT domain EIF_2_alpha PF07541.12 CDW59432.1 - 0.019 15.1 0.1 0.19 11.8 0.0 2.4 3 0 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit DUF2073 PF09846.9 CDW59432.1 - 0.088 12.7 0.7 11 6.0 0.3 2.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2073) PRA-PH PF01503.17 CDW59433.1 - 8.8e-24 83.8 0.4 7.6e-23 80.8 0.4 2.1 1 1 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase DUF4878 PF12870.7 CDW59433.1 - 0.038 14.3 0.3 0.064 13.6 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4878) Apolipoprotein PF01442.18 CDW59433.1 - 0.057 13.3 1.1 0.073 12.9 1.1 1.3 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Hydrolase_3 PF08282.12 CDW59434.1 - 7.8e-57 192.9 0.0 1.4e-56 192.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF72 PF01904.18 CDW59434.1 - 9.9e-54 182.7 0.9 1.8e-53 181.9 0.1 1.8 2 1 0 2 2 2 1 Protein of unknown function DUF72 S6PP PF05116.13 CDW59434.1 - 2.3e-16 60.1 0.0 8.7e-10 38.5 0.0 2.3 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 CDW59434.1 - 4.9e-10 40.0 0.0 0.00041 20.7 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW59434.1 - 7.1e-06 26.6 0.2 0.08 13.3 0.2 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDW59434.1 - 1.2e-05 25.5 1.4 0.0047 17.0 0.0 3.1 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW59434.1 - 0.0065 16.6 0.0 0.053 13.6 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase DUF1906 PF08924.11 CDW59434.1 - 0.022 14.9 0.0 0.06 13.5 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1906) Asparaginase PF00710.20 CDW59435.1 - 3.6e-47 160.4 0.0 4.7e-47 160.0 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CDW59435.1 - 4e-20 72.1 0.0 4.4e-19 68.8 0.0 2.4 3 0 0 3 3 3 1 Glutaminase/Asparaginase C-terminal domain HAD PF12710.7 CDW59435.1 - 0.024 15.0 0.0 3.8 7.9 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase S_100 PF01023.19 CDW59435.1 - 0.19 11.5 0.7 0.55 10.0 0.7 1.8 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Fructosamin_kin PF03881.14 CDW59436.1 - 3.2e-38 131.6 0.1 3.7e-38 131.4 0.1 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CDW59436.1 - 2.6e-06 27.5 0.0 3.1e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CDW59436.1 - 0.21 10.9 0.1 0.4 10.0 0.1 1.5 1 1 0 1 1 1 0 Ecdysteroid kinase Peptidase_C1_2 PF03051.15 CDW59437.1 - 2.2e-202 672.7 7.1 2.4e-202 672.5 7.1 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 CDW59437.1 - 9.3e-09 35.7 0.3 0.00014 22.0 0.1 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Beta-lactamase PF00144.24 CDW59438.1 - 3.7e-30 105.3 0.0 5.2e-30 104.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Crystall_3 PF08964.10 CDW59438.1 - 0.072 13.3 0.6 4.2 7.6 0.0 2.8 3 0 0 3 3 3 0 Beta/Gamma crystallin zf-Nse PF11789.8 CDW59439.1 - 4.7e-10 39.1 0.0 1.2e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 CDW59439.1 - 0.0017 18.3 0.0 0.005 16.8 0.0 1.9 1 0 0 1 1 1 1 RING-type zinc-finger ING PF12998.7 CDW59439.1 - 0.034 14.7 0.6 0.091 13.4 0.3 1.9 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Ribosomal_L30 PF00327.20 CDW59440.1 - 2.5e-22 78.5 3.9 3.4e-21 74.9 2.8 2.3 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 CDW59440.1 - 1.9e-21 76.1 12.0 1.9e-21 76.1 12.0 1.8 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain zf-RanBP PF00641.18 CDW59441.1 - 7.5e-05 22.0 10.2 7.5e-05 22.0 10.2 2.2 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others Cwf_Cwc_15 PF04889.12 CDW59441.1 - 0.004 16.9 8.1 0.0045 16.8 8.1 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein NPR3 PF03666.13 CDW59441.1 - 0.42 9.3 1.0 0.5 9.1 1.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RXT2_N PF08595.11 CDW59441.1 - 0.95 9.5 6.5 1.4 8.9 6.5 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal C5HCH PF17982.1 CDW59441.1 - 1.7 8.9 10.8 0.42 10.8 1.5 2.4 2 0 0 2 2 2 0 NSD Cys-His rich domain ALG11_N PF15924.5 CDW59442.1 - 3.3e-77 259.2 0.0 4.6e-77 258.8 0.0 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 CDW59442.1 - 9.6e-25 87.1 0.0 1.9e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CDW59442.1 - 2.6e-13 50.6 0.0 5.3e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CDW59442.1 - 1.2e-05 25.3 0.0 2.8e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CDW59442.1 - 0.0043 17.4 0.0 0.0087 16.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 BBS1 PF14779.6 CDW59443.1 - 4.9e-59 199.8 0.2 9.9e-59 198.8 0.1 1.6 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 1 PHTB1_N PF14727.6 CDW59443.1 - 3.1e-06 26.8 0.1 7.8e-05 22.2 0.0 2.2 2 0 0 2 2 2 1 PTHB1 N-terminus PQQ_3 PF13570.6 CDW59443.1 - 0.0027 18.1 0.0 21 5.8 0.0 4.0 4 0 0 4 4 4 1 PQQ-like domain Cpn60_TCP1 PF00118.24 CDW59444.1 - 1.8e-10 40.0 0.0 2.1e-07 30.0 0.0 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 CDW59445.1 - 3e-11 42.6 0.0 3.2e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 CDW59446.1 - 2.6e-06 26.4 0.6 2.1e-05 23.4 0.6 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PBP_GOBP PF01395.22 CDW59446.1 - 0.07 13.3 0.1 0.096 12.8 0.1 1.2 1 0 0 1 1 1 0 PBP/GOBP family zf-C3HC4_2 PF13923.6 CDW59447.1 - 9.3e-15 54.2 9.1 2.1e-14 53.1 9.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW59447.1 - 4e-10 39.4 9.8 1.1e-09 38.0 9.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW59447.1 - 1.6e-08 34.7 8.9 1.6e-08 34.7 8.9 2.2 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDW59447.1 - 8.3e-08 32.0 7.4 2.2e-07 30.6 7.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW59447.1 - 5.3e-07 29.6 8.5 8.8e-07 28.9 6.7 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-Nse PF11789.8 CDW59447.1 - 2.4e-06 27.3 5.3 5.1e-06 26.2 5.3 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 CDW59447.1 - 5.8e-05 23.0 8.3 0.00019 21.3 8.4 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDW59447.1 - 0.00029 20.9 6.9 0.00029 20.9 6.9 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CDW59447.1 - 0.00049 19.8 6.3 0.00049 19.8 6.3 2.0 2 0 0 2 2 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CDW59447.1 - 0.01 16.1 7.8 0.01 16.1 7.8 2.6 3 1 0 3 3 2 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 CDW59447.1 - 0.013 15.4 3.3 0.013 15.4 3.3 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 CDW59447.1 - 0.017 15.0 7.2 0.017 15.0 7.2 2.6 3 1 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 CDW59447.1 - 0.022 14.5 5.8 0.053 13.3 5.8 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger RAWUL PF16207.5 CDW59447.1 - 0.022 15.4 0.2 0.042 14.5 0.2 1.6 1 1 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_10 PF16685.5 CDW59447.1 - 0.048 13.8 9.2 0.04 14.1 6.9 2.1 2 0 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 CDW59447.1 - 0.08 12.8 8.4 2.7 7.9 9.1 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 CDW59447.1 - 0.19 11.5 4.0 0.53 10.1 4.0 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-UDP PF14569.6 CDW59447.1 - 0.45 10.7 4.5 1.9 8.6 4.5 2.1 1 1 0 1 1 1 0 Zinc-binding RING-finger DZR PF12773.7 CDW59447.1 - 5.7 7.0 9.4 11 6.2 6.5 2.7 1 1 1 2 2 2 0 Double zinc ribbon AMP-binding PF00501.28 CDW59448.1 - 5.1e-89 298.8 0.0 6.9e-89 298.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW59448.1 - 2.3e-05 25.3 0.0 8e-05 23.5 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 CDW59449.1 - 1.1e-07 31.6 0.0 1.8e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDW59449.1 - 2.1e-07 30.3 0.0 1.3e-06 27.8 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CDW59449.1 - 2.4e-07 30.8 0.0 3.5e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CDW59449.1 - 0.00031 20.4 0.0 0.00048 19.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 CDW59449.1 - 0.0018 17.4 0.0 0.025 13.6 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CDW59449.1 - 0.0031 16.7 0.0 2 7.5 0.0 2.9 4 0 0 4 4 4 2 Male sterility protein Putative_PNPOx PF01243.20 CDW59450.1 - 2.4e-14 53.3 0.0 3.9e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 CDW59450.1 - 1.1e-08 35.6 0.0 3.6e-08 33.9 0.0 1.8 3 0 0 3 3 3 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 CDW59450.1 - 4.6e-07 29.8 0.0 8.5e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region GCP_N_terminal PF17681.1 CDW59451.1 - 1.6e-22 80.6 0.7 2.5e-22 79.9 0.7 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CDW59451.1 - 1.2e-06 28.2 11.9 3.3e-06 26.8 9.4 2.9 2 1 0 2 2 2 1 Gamma tubulin complex component C-terminal T6PP_N PF18572.1 CDW59451.1 - 0.099 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain 7tm_2 PF00002.24 CDW59452.1 - 3.4e-34 118.2 18.4 4.8e-34 117.7 18.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 CDW59452.1 - 8.9e-14 51.5 3.7 1.1e-13 51.2 2.0 2.0 2 0 0 2 2 2 1 Hormone receptor domain Tubulin PF00091.25 CDW59454.1 - 5.4e-68 229.1 0.0 7.3e-68 228.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDW59454.1 - 1.8e-51 173.6 0.0 2.8e-51 172.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CDW59454.1 - 0.0022 17.7 0.0 0.0042 16.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Methyltr_RsmB-F PF01189.17 CDW59455.1 - 1.2e-25 90.4 0.1 3.6e-16 59.4 0.0 2.3 1 1 1 2 2 2 2 16S rRNA methyltransferase RsmB/F PUA PF01472.20 CDW59455.1 - 0.00027 20.8 0.0 0.00058 19.8 0.0 1.6 1 0 0 1 1 1 1 PUA domain FtsJ PF01728.19 CDW59455.1 - 0.0026 17.9 0.0 0.0044 17.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CDW59455.1 - 0.0059 16.4 0.0 0.016 15.0 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CDW59455.1 - 0.011 15.5 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 CDW59455.1 - 0.033 13.7 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Fibrillarin PF01269.17 CDW59455.1 - 0.16 11.0 0.0 0.51 9.4 0.0 1.8 2 0 0 2 2 2 0 Fibrillarin M_domain PF12938.7 CDW59456.1 - 4e-07 30.1 9.6 4e-07 30.1 9.6 4.4 3 1 1 4 4 4 1 M domain of GW182 Kunitz_BPTI PF00014.23 CDW59458.1 - 7.2e-194 628.1 177.2 2.7e-20 72.3 6.7 12.0 12 0 0 12 12 12 12 Kunitz/Bovine pancreatic trypsin inhibitor domain SAD_SRA PF02182.17 CDW59458.1 - 0.031 14.0 9.6 72 3.0 0.0 7.3 7 3 2 9 9 9 0 SAD/SRA domain DHHC PF01529.20 CDW59459.1 - 1.5e-29 102.8 10.5 1.5e-29 102.8 10.5 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase UPF0113_N PF17833.1 CDW59460.1 - 2.6e-24 85.6 0.8 7.8e-24 84.0 0.8 1.9 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 CDW59460.1 - 3e-23 81.9 0.0 8.3e-23 80.5 0.0 1.8 1 0 0 1 1 1 1 UPF0113 PUA domain DEAD PF00270.29 CDW59460.1 - 3.1e-14 53.1 0.0 2.2e-13 50.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CDW59460.1 - 5.1e-11 42.9 0.0 9.3e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DNA_pol_lambd_f PF10391.9 CDW59460.1 - 0.00015 21.6 0.0 0.00033 20.4 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_5 PF14520.6 CDW59460.1 - 0.0012 19.4 0.1 0.0037 17.8 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain CRISPR_Cas2 PF09827.9 CDW59460.1 - 0.011 15.8 0.0 0.062 13.5 0.0 2.3 2 0 0 2 2 2 0 CRISPR associated protein Cas2 DUF4332 PF14229.6 CDW59460.1 - 0.014 15.6 0.3 0.034 14.4 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) IstB_IS21 PF01695.17 CDW59460.1 - 0.037 13.8 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein Serpin PF00079.20 CDW59461.1 - 8e-113 377.5 5.0 1e-112 377.2 5.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) OST3_OST6 PF04756.13 CDW59461.1 - 0.0096 15.3 0.2 0.02 14.3 0.2 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF5075 PF16825.5 CDW59461.1 - 0.14 11.9 0.3 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 IGP family C-type lectin domain MCM PF00493.23 CDW59462.1 - 4.1e-93 310.6 0.0 5.9e-93 310.1 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CDW59462.1 - 1.4e-35 121.9 0.0 2.6e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CDW59462.1 - 1.5e-25 89.4 0.7 3.5e-25 88.2 0.7 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CDW59462.1 - 1.9e-16 60.5 3.2 4.2e-16 59.4 1.3 2.6 3 0 0 3 3 3 1 MCM N-terminal domain AAA_5 PF07728.14 CDW59462.1 - 1.1e-10 41.6 0.0 3.7e-10 39.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CDW59462.1 - 7.9e-09 35.2 0.1 1.7e-05 24.3 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDW59462.1 - 0.00032 20.5 0.0 0.0007 19.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RcpC PF16976.5 CDW59462.1 - 0.0011 19.0 0.0 0.0027 17.8 0.0 1.6 1 0 0 1 1 1 1 Flp pilus assembly protein RcpC/CpaB Sigma54_activat PF00158.26 CDW59462.1 - 0.0085 15.8 0.0 4.8 6.9 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 CDW59462.1 - 0.042 14.2 1.4 0.64 10.4 0.1 3.3 3 1 1 4 4 4 0 AAA ATPase domain AAA_7 PF12775.7 CDW59462.1 - 0.09 12.3 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region NTPase_1 PF03266.15 CDW59462.1 - 0.12 12.3 0.0 15 5.4 0.0 2.5 1 1 0 2 2 2 0 NTPase Zn-ribbon_8 PF09723.10 CDW59462.1 - 0.22 11.7 0.6 0.51 10.5 0.6 1.6 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_4 PF13894.6 CDW59463.1 - 8.6e-11 41.7 20.1 0.032 15.1 0.5 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW59463.1 - 3.5e-09 36.6 23.1 0.013 15.9 1.1 4.5 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW59463.1 - 3.5e-07 30.3 11.9 0.0056 17.1 0.4 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf-Di19 PF05605.12 CDW59463.1 - 0.084 13.2 11.6 0.17 12.2 1.9 3.5 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 CDW59463.1 - 0.085 13.2 0.1 0.085 13.2 0.1 4.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CDW59463.1 - 0.29 11.6 15.4 0.45 11.0 0.2 3.7 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 CDW59463.1 - 0.31 11.8 3.8 3 8.7 1.5 2.4 1 1 1 2 2 2 0 zinc-ribbon family zf-C2H2_2 PF12756.7 CDW59463.1 - 0.56 10.6 10.2 5.9 7.3 1.1 3.9 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 CDW59463.1 - 0.57 10.3 19.5 0.69 10.0 0.4 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW59464.1 - 1.4e-20 72.5 61.1 6.4e-06 26.3 0.8 8.1 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW59464.1 - 7.3e-18 63.7 57.5 0.0001 22.8 0.5 8.3 8 0 0 8 8 8 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW59464.1 - 2.3e-13 49.9 65.5 2.4e-06 27.7 0.2 8.7 9 0 0 9 9 8 5 Zinc-finger double domain zf-C2H2_6 PF13912.6 CDW59464.1 - 3.3e-08 33.3 36.3 0.00097 19.1 0.1 6.7 6 0 0 6 6 6 5 C2H2-type zinc finger zf-met PF12874.7 CDW59464.1 - 6e-08 32.8 34.2 0.25 11.8 0.1 7.3 7 0 0 7 7 7 5 Zinc-finger of C2H2 type zf_UBZ PF18439.1 CDW59464.1 - 5.1e-06 26.0 12.7 0.51 10.0 0.1 5.6 5 0 0 5 5 5 3 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 CDW59464.1 - 7.9e-05 22.5 0.2 7.9e-05 22.5 0.2 5.0 7 0 0 7 7 6 1 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 CDW59464.1 - 0.011 15.5 0.9 0.011 15.5 0.9 5.5 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 CDW59464.1 - 0.012 15.9 46.9 0.19 12.0 0.0 7.1 8 1 0 8 8 6 0 Zinc-finger double-stranded RNA-binding RYDR_ITPR PF01365.21 CDW59464.1 - 0.016 14.6 0.8 0.031 13.7 0.8 1.4 1 0 0 1 1 1 0 RIH domain C1_4 PF07975.12 CDW59464.1 - 0.05 13.8 0.7 0.05 13.8 0.7 5.6 2 2 2 6 6 6 0 TFIIH C1-like domain zf-C2H2_9 PF16293.5 CDW59464.1 - 0.17 11.7 25.6 4.8 7.1 0.8 7.1 5 2 3 8 8 8 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_15 PF17032.5 CDW59464.1 - 0.27 12.0 24.6 1.6 9.5 1.0 3.7 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_2 PF12756.7 CDW59464.1 - 1.1 9.6 43.5 1.6 9.1 3.9 6.8 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 CDW59464.1 - 1.3 9.2 27.3 2.8 8.1 3.7 6.0 2 1 4 6 6 6 0 Zinc ribbon domain Propeptide_C25 PF08126.11 CDW59465.1 - 0.087 11.9 0.1 0.15 11.1 0.1 1.4 1 0 0 1 1 1 0 Propeptide_C25 Whirly PF08536.11 CDW59465.1 - 0.097 12.5 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Whirly transcription factor PAP_assoc PF03828.19 CDW59466.1 - 2.5e-17 62.8 0.0 9.4e-17 61.0 0.0 2.0 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDW59466.1 - 9.2e-12 45.1 0.0 3.1e-11 43.4 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 CDW59466.1 - 0.047 13.8 0.0 0.098 12.8 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Cys_Met_Meta_PP PF01053.20 CDW59467.1 - 1.1e-124 415.9 0.0 4.1e-110 367.9 0.0 2.0 2 0 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CDW59467.1 - 5.9e-06 25.7 0.1 1e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Paramyxo_C PF01692.18 CDW59467.1 - 0.14 11.5 0.1 0.31 10.4 0.1 1.5 2 0 0 2 2 2 0 Paramyxovirus non-structural protein C Trypsin PF00089.26 CDW59468.1 - 1.5e-86 289.8 0.0 7.3e-56 189.4 0.0 2.9 2 1 0 2 2 2 2 Trypsin DUF1986 PF09342.11 CDW59468.1 - 8.8e-07 29.3 0.0 0.01 16.2 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 CDW59468.1 - 0.0016 19.4 0.0 0.0051 17.7 0.0 1.8 2 0 0 2 2 2 1 Trypsin-like peptidase domain L_HMGIC_fpl PF10242.9 CDW59469.1 - 4.5e-33 115.0 12.0 5.5e-33 114.7 3.5 2.0 1 1 1 2 2 2 2 Lipoma HMGIC fusion partner-like protein Nup54 PF13874.6 CDW59472.1 - 3.9e-12 46.5 0.0 8.3e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 DDE_1 PF03184.19 CDW59472.1 - 8.3e-06 25.6 0.0 1.8e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3683 PF12447.8 CDW59473.1 - 0.0089 16.2 0.3 0.011 15.9 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3683) HTH_11 PF08279.12 CDW59473.1 - 0.054 13.4 0.8 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 HTH domain FapA PF03961.13 CDW59473.1 - 0.07 11.7 4.4 0.074 11.7 4.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Herpes_UL92 PF03048.14 CDW59473.1 - 0.07 12.9 0.1 0.072 12.9 0.1 1.1 1 0 0 1 1 1 0 UL92 family CorA PF01544.18 CDW59473.1 - 0.12 11.7 1.3 0.12 11.7 1.3 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein MazG PF03819.17 CDW59473.1 - 0.19 11.9 4.7 2.2 8.5 2.6 2.1 1 1 1 2 2 2 0 MazG nucleotide pyrophosphohydrolase domain Pox_A_type_inc PF04508.12 CDW59473.1 - 0.86 9.6 6.7 3.5 7.7 0.0 3.3 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat bZIP_2 PF07716.15 CDW59473.1 - 5.8 7.1 9.6 4.6 7.4 3.4 2.3 2 0 0 2 2 2 0 Basic region leucine zipper LBP_BPI_CETP_C PF02886.17 CDW59475.1 - 4.7e-16 59.0 2.1 8.6e-16 58.1 2.1 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain SR-25 PF10500.9 CDW59475.1 - 0.089 12.4 20.4 0.14 11.7 20.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 CDW59475.1 - 0.21 11.8 21.2 0.38 11.0 21.2 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Eapp_C PF10238.9 CDW59475.1 - 0.27 11.3 11.5 0.69 10.0 11.5 1.6 1 1 0 1 1 1 0 E2F-associated phosphoprotein Connexin PF00029.19 CDW59475.1 - 0.71 9.6 4.9 0.98 9.1 3.1 1.9 2 0 0 2 2 2 0 Connexin Med19 PF10278.9 CDW59475.1 - 2 8.3 18.3 3.7 7.5 18.3 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 TFIIE-A_C PF11521.8 CDW59475.1 - 2.8 8.3 7.6 6.4 7.1 7.6 1.5 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha PBP_sp32 PF07222.12 CDW59475.1 - 4.6 6.6 10.4 9.2 5.6 10.4 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Pox_Ag35 PF03286.14 CDW59475.1 - 6.7 6.4 15.3 13 5.6 15.3 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein OAF PF14941.6 CDW59476.1 - 0.16 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator, Out at first DUF5496 PF17600.2 CDW59477.1 - 0.13 12.3 0.0 13 5.9 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5496) Phage_TAC_10 PF10963.8 CDW59478.1 - 0.17 12.1 0.0 0.28 11.4 0.0 1.3 1 0 0 1 1 1 0 Phage tail assembly chaperone Thioredoxin PF00085.20 CDW59480.1 - 1.1e-62 208.5 0.1 2.2e-31 107.9 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 CDW59480.1 - 6.9e-32 110.8 6.6 8.5e-27 94.3 4.7 3.6 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDW59480.1 - 1e-08 35.6 3.5 0.00011 22.6 0.1 3.8 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CDW59480.1 - 9e-08 32.4 0.2 0.1 12.9 0.0 4.5 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 CDW59480.1 - 3.2e-06 27.0 1.4 0.26 11.2 0.0 3.3 2 1 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.6 CDW59480.1 - 7.4e-06 26.1 0.0 0.034 14.3 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 CDW59480.1 - 0.00027 20.7 0.1 5.5 6.7 0.0 3.4 3 0 0 3 3 3 2 Redoxin Thioredoxin_4 PF13462.6 CDW59480.1 - 0.041 14.0 0.2 6.3 6.9 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin OST3_OST6 PF04756.13 CDW59480.1 - 0.042 13.2 0.0 0.69 9.2 0.0 2.4 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 CDW59480.1 - 0.064 13.5 0.4 3.6 7.9 0.0 2.9 3 0 0 3 3 3 0 Glutaredoxin DUF3000 PF11452.8 CDW59480.1 - 0.1 12.1 0.0 0.22 11.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3000) Pkinase PF00069.25 CDW59481.1 - 6.3e-65 219.1 0.0 8e-65 218.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59481.1 - 7.1e-35 120.5 0.0 9.1e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW59481.1 - 5.5e-08 32.5 0.0 7.7e-08 32.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CDW59481.1 - 0.017 14.1 0.1 0.036 13.0 0.1 1.6 1 1 0 1 1 1 0 Haspin like kinase domain RRM_1 PF00076.22 CDW59482.1 - 4.1e-17 61.8 0.1 6.3e-17 61.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW59482.1 - 0.012 15.7 0.1 0.038 14.1 0.1 1.8 1 1 0 1 1 1 0 RNA recognition motif RRM_3 PF08777.11 CDW59482.1 - 0.21 11.7 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif TAF PF02969.17 CDW59483.1 - 3.7e-05 23.8 0.0 5.6e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Imm65 PF15582.6 CDW59483.1 - 0.072 11.9 0.0 0.077 11.8 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 65 DUF4303 PF14136.6 CDW59483.1 - 0.09 12.5 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) Uds1 PF15456.6 CDW59484.1 - 0.00013 22.1 8.8 28 4.9 4.1 7.2 3 3 3 7 7 7 2 Up-regulated During Septation PQQ PF01011.21 CDW59484.1 - 0.001 18.9 11.5 43 4.3 0.0 7.2 8 0 0 8 8 8 1 PQQ enzyme repeat Cmc1 PF08583.10 CDW59484.1 - 0.039 14.0 1.3 0.039 14.0 1.3 3.6 2 1 2 4 4 4 0 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_UQCRX_QCR9 PF05365.12 CDW59484.1 - 0.068 13.1 6.0 58 3.7 0.1 5.6 5 2 1 6 6 6 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like AraC_binding_2 PF14525.6 CDW59485.1 - 0.045 13.4 0.9 2.3 7.9 0.2 3.1 1 1 0 2 2 2 0 AraC-binding-like domain Uds1 PF15456.6 CDW59485.1 - 0.069 13.3 0.0 26 5.0 0.0 3.4 2 1 0 2 2 2 0 Up-regulated During Septation Ant_C PF05586.11 CDW59485.1 - 0.17 12.5 1.2 28 5.4 0.1 2.9 1 1 1 2 2 2 0 Anthrax receptor C-terminus region DUF1966 PF09260.11 CDW59485.1 - 0.22 11.8 1.5 4 7.8 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1966) Periviscerokin PF08259.11 CDW59485.1 - 8.2 7.1 12.7 17 6.1 0.2 4.3 5 0 0 5 5 5 0 Periviscerokinin family DUF1744 PF08490.12 CDW59486.1 - 3.6e-83 279.4 0.0 5.8e-83 278.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 CDW59486.1 - 9.5e-68 228.8 0.7 7.1e-67 225.9 0.2 2.4 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 CDW59486.1 - 9.5e-12 44.4 0.0 3.5e-10 39.2 0.0 3.0 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 CDW59486.1 - 4.8e-07 29.7 0.1 1.4e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 CDW59486.1 - 2.9e-05 24.1 0.0 0.00011 22.3 0.0 2.0 1 0 0 1 1 1 1 RNase_H superfamily Protamine_P2 PF00841.19 CDW59486.1 - 6.6 7.3 8.4 15 6.2 8.4 1.5 1 0 0 1 1 1 0 Sperm histone P2 AA_kinase PF00696.28 CDW59487.1 - 1.1e-25 90.7 0.4 2.3e-25 89.6 0.4 1.5 1 1 0 1 1 1 1 Amino acid kinase family Amidohydro_3 PF07969.11 CDW59488.1 - 2.2e-15 57.1 0.5 1.6e-10 41.0 0.0 2.1 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 CDW59488.1 - 9.6e-08 31.7 0.0 1.4e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family HTH_ParB PF17762.1 CDW59488.1 - 0.041 13.7 0.1 0.09 12.6 0.1 1.6 1 0 0 1 1 1 0 HTH domain found in ParB protein ADH_N PF08240.12 CDW59489.1 - 2.5e-27 94.9 5.6 4.5e-27 94.1 5.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CDW59489.1 - 3.2e-26 91.9 0.1 5.3e-26 91.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDW59489.1 - 4.8e-07 30.9 0.0 1.1e-06 29.8 0.0 1.6 2 0 0 2 2 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CDW59489.1 - 6.9e-07 28.8 0.2 1.2e-06 28.0 0.2 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 CDW59489.1 - 1.2e-05 24.8 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CDW59489.1 - 0.00056 20.1 0.1 0.001 19.3 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Oxidored_nitro PF00148.19 CDW59489.1 - 0.0016 17.2 0.0 0.0023 16.7 0.0 1.2 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase Glu_dehyd_C PF16912.5 CDW59489.1 - 0.013 15.0 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Shikimate_DH PF01488.20 CDW59489.1 - 0.015 15.3 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CDW59489.1 - 0.058 13.7 0.2 0.18 12.1 0.1 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Methyltransf_11 PF08241.12 CDW59489.1 - 0.062 14.0 0.1 0.12 13.0 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_N PF02737.18 CDW59489.1 - 0.16 11.8 0.3 0.25 11.2 0.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sigma54_activat PF00158.26 CDW59490.1 - 1.3e-64 217.0 0.1 2e-64 216.3 0.1 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain PrpR_N PF06506.11 CDW59490.1 - 5.7e-50 169.1 0.2 9e-50 168.5 0.2 1.3 1 0 0 1 1 1 1 Propionate catabolism activator LysE PF01810.18 CDW59490.1 - 7.4e-29 100.6 10.0 1.4e-26 93.1 1.3 2.6 2 1 1 3 3 3 2 LysE type translocator Sigma54_activ_2 PF14532.6 CDW59490.1 - 9.9e-19 67.8 0.0 4.1e-18 65.8 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 CDW59490.1 - 7.4e-05 22.2 0.3 0.00021 20.8 0.3 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDW59490.1 - 0.0037 17.3 0.0 0.039 13.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDW59490.1 - 0.0055 17.1 0.0 0.014 15.8 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 CDW59490.1 - 0.038 14.1 0.0 0.099 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) TerC PF03741.16 CDW59490.1 - 0.041 13.6 0.5 0.095 12.4 0.2 1.7 1 1 0 1 1 1 0 Integral membrane protein TerC family Citrate_synt PF00285.21 CDW59491.1 - 1.5e-114 382.8 0.0 2.4e-114 382.2 0.0 1.3 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain PEP_mutase PF13714.6 CDW59491.1 - 9.8e-49 166.0 4.2 1.9e-48 165.0 4.2 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CDW59491.1 - 1e-13 50.7 0.7 1.9e-13 49.7 0.7 1.4 1 0 0 1 1 1 1 Isocitrate lyase family MmgE_PrpD PF03972.14 CDW59492.1 - 2.4e-157 524.0 0.8 2.5e-157 523.9 0.0 1.4 2 0 0 2 2 2 1 MmgE/PrpD family AMP-binding PF00501.28 CDW59492.1 - 3e-74 250.1 0.0 4.4e-74 249.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW59492.1 - 4e-23 82.2 0.2 1.1e-22 80.7 0.2 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF3147 PF11345.8 CDW59492.1 - 0.069 13.5 0.3 0.22 11.9 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) Pro_CA PF00484.19 CDW59493.1 - 2.5e-49 167.5 0.0 2.9e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 Carbonic anhydrase H_kinase_N PF12282.8 CDW59493.1 - 0.043 13.8 0.2 0.18 11.7 0.2 1.9 1 1 0 1 1 1 0 Signal transduction histidine kinase Cyanate_lyase PF02560.14 CDW59494.1 - 3.1e-32 110.2 0.0 4.3e-32 109.8 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain MFS_1 PF07690.16 CDW59495.1 - 1.3e-23 83.5 46.3 1.3e-23 83.5 46.3 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CDW59495.1 - 2e-08 34.0 37.3 3e-08 33.4 37.3 1.4 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB Sugar_tr PF00083.24 CDW59495.1 - 5.7e-06 25.4 31.2 3.8e-05 22.8 13.1 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter DUF3392 PF11872.8 CDW59495.1 - 0.17 12.2 8.8 2.7 8.3 1.7 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3392) Trypsin PF00089.26 CDW59497.1 - 1.5e-68 230.9 0.0 7.5e-35 120.7 0.0 2.7 2 2 0 2 2 2 2 Trypsin Trypsin_2 PF13365.6 CDW59497.1 - 3.2e-14 54.1 0.0 1.1e-07 32.9 0.0 2.5 2 1 0 2 2 2 2 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW59497.1 - 0.097 13.1 0.0 1.4 9.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1986) DUF4974 PF16344.5 CDW59498.1 - 0.00024 21.0 0.1 2.4 8.2 0.0 3.5 4 0 0 4 4 4 2 Domain of unknown function (DUF4974) DUF3253 PF11625.8 CDW59498.1 - 0.00036 20.7 0.0 1 9.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3253) DUF2555 PF10742.9 CDW59498.1 - 0.0077 16.0 0.0 5.6 6.9 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF2555) nlz1 PF12402.8 CDW59498.1 - 0.008 16.6 0.0 5.3 7.5 0.0 2.3 2 0 0 2 2 2 2 NocA-like zinc-finger protein 1 LrgA PF03788.14 CDW59498.1 - 0.15 12.0 0.0 23 5.0 0.0 2.2 2 0 0 2 2 2 0 LrgA family tRNA-synt_His PF13393.6 CDW59499.1 - 5.1e-30 104.8 0.0 8.8e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 CDW59499.1 - 4e-13 49.3 0.0 9.2e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 CDW59499.1 - 4.9e-06 26.3 0.1 7.4e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs SNF2_N PF00176.23 CDW59500.1 - 3.5e-48 164.1 3.6 4.1e-48 163.9 0.1 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW59500.1 - 3.4e-14 53.1 0.0 1.2e-13 51.3 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW59500.1 - 4.4e-05 23.5 0.0 0.00012 22.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CDW59500.1 - 0.002 17.9 0.0 0.025 14.2 0.0 2.3 1 1 0 1 1 1 1 SWI2/SNF2 ATPase SR-25 PF10500.9 CDW59500.1 - 0.054 13.1 14.3 0.1 12.2 14.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 CDW59500.1 - 0.36 11.2 12.3 0.76 10.1 12.3 1.4 1 0 0 1 1 1 0 Early growth response N-terminal domain MCM PF00493.23 CDW59502.1 - 2.2e-55 187.2 0.0 3.2e-55 186.7 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 CDW59502.1 - 1e-12 48.3 1.7 7.5e-11 42.3 1.7 2.4 1 1 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 CDW59502.1 - 9.2e-12 44.8 0.5 6e-06 25.8 0.1 3.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CDW59502.1 - 3.9e-06 26.9 0.0 0.00011 22.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CDW59502.1 - 0.0049 16.7 0.0 0.014 15.2 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CDW59502.1 - 0.0066 16.2 0.0 3 7.5 0.0 2.5 3 0 0 3 3 3 2 Sigma-54 interaction domain RuvB_N PF05496.12 CDW59502.1 - 0.02 14.7 0.0 0.068 12.9 0.0 1.8 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 CDW59502.1 - 0.036 14.5 0.0 0.14 12.6 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CDW59502.1 - 0.046 13.2 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 CDW59502.1 - 0.15 12.4 1.3 0.65 10.4 0.1 2.5 2 2 1 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 CDW59502.1 - 0.17 12.2 0.8 4.3 7.6 0.1 2.8 2 2 1 3 3 3 0 AAA domain Pkinase PF00069.25 CDW59503.1 - 6.4e-27 94.6 0.0 9.1e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59503.1 - 8.4e-06 25.3 0.0 1.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW59503.1 - 0.0022 17.4 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Retrotran_gag_2 PF14223.6 CDW59504.1 - 0.068 12.8 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type FYVE PF01363.21 CDW59506.1 - 3.8e-21 75.0 13.3 9e-21 73.8 12.2 2.1 2 0 0 2 2 2 1 FYVE zinc finger Vac14_Fig4_bd PF11916.8 CDW59506.1 - 0.031 13.9 1.4 0.065 12.9 0.1 1.9 2 0 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding HisKA PF00512.25 CDW59506.1 - 0.065 13.3 1.5 0.094 12.8 0.1 1.9 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain ELM2 PF01448.24 CDW59507.1 - 0.0012 19.5 0.0 0.0015 19.2 0.0 1.5 1 1 0 1 1 1 1 ELM2 domain TIL PF01826.17 CDW59508.1 - 6.9e-14 51.8 19.8 8.3e-14 51.6 19.8 1.1 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain I-EGF_1 PF18372.1 CDW59509.1 - 0.16 12.1 2.4 0.22 11.6 2.4 1.2 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 CarboxypepD_reg PF13620.6 CDW59510.1 - 0.00014 22.1 0.0 0.00018 21.7 0.0 1.1 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 CDW59510.1 - 0.00058 20.1 0.0 0.0008 19.6 0.0 1.1 1 0 0 1 1 1 1 SdrD B-like domain CTK3 PF12243.8 CDW59511.1 - 0.067 13.2 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 Peptidase_C1 PF00112.23 CDW59512.1 - 9.5e-68 228.5 0.5 1.2e-67 228.3 0.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 CDW59512.1 - 0.0085 14.9 2.2 0.24 10.2 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 CDW59512.1 - 0.096 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C1 propeptide Fibrinogen_C PF00147.18 CDW59513.1 - 2.9e-56 190.7 3.3 4.7e-56 190.1 3.3 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Pro-rich_19 PF15455.6 CDW59513.1 - 0.0044 16.2 0.0 0.007 15.6 0.0 1.2 1 0 0 1 1 1 1 Proline-rich 19 LXG PF04740.12 CDW59513.1 - 0.078 12.7 6.1 0.29 10.8 0.1 2.5 2 0 0 2 2 2 0 LXG domain of WXG superfamily Baculo_PEP_C PF04513.12 CDW59513.1 - 0.41 10.7 0.0 0.41 10.7 0.0 3.9 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus XPA_C PF05181.12 CDW59514.1 - 1.5e-23 82.5 0.6 2.8e-23 81.6 0.6 1.5 1 0 0 1 1 1 1 XPA protein C-terminus Integrase_H2C2 PF17921.1 CDW59514.1 - 2.7e-20 72.2 0.6 7e-20 70.9 0.6 1.8 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDW59514.1 - 6.3e-20 71.5 0.0 1.2e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain XPA_N PF01286.18 CDW59514.1 - 1.4e-06 28.2 6.8 1.4e-06 28.2 6.8 1.9 2 0 0 2 2 2 1 XPA protein N-terminal zf-H2C2 PF09337.10 CDW59514.1 - 6.4e-05 23.1 0.2 0.00022 21.4 0.0 2.1 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 CDW59514.1 - 0.00098 18.9 0.0 0.0029 17.3 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain KH_1 PF00013.29 CDW59515.1 - 0.045 13.6 0.0 0.096 12.5 0.0 1.5 1 0 0 1 1 1 0 KH domain GcpE PF04551.14 CDW59517.1 - 0.032 13.3 0.1 0.037 13.1 0.1 1.2 1 0 0 1 1 1 0 GcpE protein KH_1 PF00013.29 CDW59518.1 - 1.7e-06 27.7 0.1 0.01 15.6 0.0 2.7 2 0 0 2 2 2 2 KH domain Hid1 PF12722.7 CDW59518.1 - 1 7.4 7.3 2 6.4 7.3 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Collagen PF01391.18 CDW59519.1 - 2.8 7.7 19.4 21 5.0 0.3 3.9 3 1 0 3 3 3 0 Collagen triple helix repeat (20 copies) gag-asp_proteas PF13975.6 CDW59520.1 - 0.018 15.6 0.0 0.057 14.0 0.0 1.9 1 1 1 2 2 2 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW59520.1 - 0.069 13.8 0.0 0.17 12.5 0.0 1.8 1 1 0 1 1 1 0 Aspartyl protease DUF5641 PF18701.1 CDW59521.1 - 6.9e-33 112.7 0.5 1.2e-32 112.0 0.5 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5641) rve_3 PF13683.6 CDW59521.1 - 0.031 14.0 0.0 0.079 12.7 0.0 1.7 2 0 0 2 2 2 0 Integrase core domain SCFA_trans PF02667.14 CDW59521.1 - 0.062 12.3 0.0 0.082 11.9 0.0 1.1 1 0 0 1 1 1 0 Short chain fatty acid transporter rve PF00665.26 CDW59521.1 - 0.13 12.5 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain DUF2717 PF10911.8 CDW59522.1 - 0.18 11.5 0.0 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2717) WD40 PF00400.32 CDW59524.1 - 6.7e-07 29.9 3.0 0.014 16.2 0.0 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat NumbF PF06311.12 CDW59524.1 - 0.14 12.7 0.1 0.25 11.9 0.1 1.3 1 0 0 1 1 1 0 NUMB domain zf-RING_2 PF13639.6 CDW59530.1 - 0.0025 18.1 9.7 0.0045 17.3 9.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CDW59530.1 - 0.0044 16.9 10.0 0.0074 16.2 10.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain DUF3391 PF11871.8 CDW59530.1 - 0.0089 16.6 3.6 0.012 16.1 3.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3391) Sec20 PF03908.13 CDW59530.1 - 0.022 14.7 3.6 0.033 14.1 3.6 1.4 1 0 0 1 1 1 0 Sec20 zf-C3HC4 PF00097.25 CDW59530.1 - 0.03 14.2 6.7 0.081 12.8 6.7 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDW59530.1 - 0.031 14.1 8.2 0.063 13.1 8.2 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDW59530.1 - 0.056 13.2 5.2 0.056 13.2 5.2 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-C3H2C3 PF17122.5 CDW59530.1 - 0.19 11.8 3.7 0.16 12.1 2.4 1.6 1 1 0 1 1 1 0 Zinc-finger OEP PF02321.18 CDW59530.1 - 0.35 10.6 8.2 0.45 10.3 8.2 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein FYDLN_acid PF09538.10 CDW59530.1 - 0.87 10.3 5.9 2.1 9.0 5.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) PHD PF00628.29 CDW59530.1 - 0.94 9.4 8.5 14 5.7 4.3 2.5 1 1 1 2 2 2 0 PHD-finger zf-RING_UBOX PF13445.6 CDW59530.1 - 4.5 7.4 9.3 19 5.4 9.3 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 CDW59530.1 - 6.4 7.1 9.7 30 5.0 9.7 2.1 1 1 0 1 1 1 0 RING-H2 zinc finger domain ResIII PF04851.15 CDW59533.1 - 2.5e-23 82.9 0.0 1.4e-22 80.5 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CDW59533.1 - 2.3e-17 63.3 0.0 1.1e-16 61.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW59533.1 - 4.1e-15 56.0 0.0 8e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF2161 PF09929.9 CDW59533.1 - 0.012 15.7 0.2 0.057 13.5 0.0 2.1 2 1 0 2 2 2 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) DUF2075 PF09848.9 CDW59533.1 - 0.016 14.4 0.0 0.024 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF3903 PF13043.6 CDW59533.1 - 0.078 12.7 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3903) Laminin_G_2 PF02210.24 CDW59534.1 - 1.8e-27 96.4 0.5 1.9e-10 41.4 0.0 5.4 5 0 0 5 5 5 4 Laminin G domain Laminin_G_1 PF00054.23 CDW59534.1 - 5.3e-13 49.3 0.0 0.0017 18.6 0.0 6.0 5 2 0 5 5 5 4 Laminin G domain Fibrinogen_C PF00147.18 CDW59534.1 - 0.0018 18.1 0.0 0.0057 16.5 0.0 1.8 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 CDW59534.1 - 0.038 13.3 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain TMEM154 PF15102.6 CDW59534.1 - 0.088 12.7 0.9 0.19 11.7 0.9 1.5 1 0 0 1 1 1 0 TMEM154 protein family EST1_DNA_bind PF10373.9 CDW59535.1 - 0.014 14.9 0.1 0.024 14.1 0.1 1.3 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain HNH_repeat PF18780.1 CDW59535.1 - 0.29 11.0 1.1 0.77 9.6 1.1 1.8 1 0 0 1 1 1 0 Homing endonuclease repeat Kinesin PF00225.23 CDW59536.1 - 1.8e-81 273.7 0.0 3.2e-81 272.8 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CDW59536.1 - 5.3e-16 58.9 0.2 1.1e-15 57.8 0.2 1.6 1 0 0 1 1 1 1 Microtubule binding Swi3 PF07962.12 CDW59537.1 - 4.4e-19 68.2 0.0 7.3e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 DUF1682 PF07946.14 CDW59537.1 - 0.21 10.8 5.3 0.3 10.2 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Presenilin PF01080.17 CDW59537.1 - 6.7 5.4 5.2 8.1 5.1 5.2 1.1 1 0 0 1 1 1 0 Presenilin Haspin_kinase PF12330.8 CDW59538.1 - 1.6e-49 168.8 0.2 2e-49 168.5 0.2 1.0 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CDW59538.1 - 0.0014 18.6 0.0 0.0056 16.6 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 CDW59538.1 - 0.015 14.7 0.1 0.023 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein kinase domain Asp_protease_2 PF13650.6 CDW59540.1 - 0.0035 18.0 0.0 0.02 15.5 0.0 2.1 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW59540.1 - 0.014 16.0 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease LBP_BPI_CETP_C PF02886.17 CDW59541.1 - 5.6e-17 62.0 0.1 8.9e-17 61.3 0.1 1.3 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 CDW59541.1 - 0.0003 20.4 0.0 0.00087 18.9 0.0 1.8 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Tryp_FSAP PF08248.11 CDW59541.1 - 2.9 8.6 7.1 6.4 7.6 7.1 1.6 1 0 0 1 1 1 0 Tryptophyllin-3 skin active peptide KH_1 PF00013.29 CDW59544.1 - 1.9e-45 152.5 7.1 5.9e-18 64.5 1.4 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CDW59544.1 - 4.1e-17 61.8 1.9 6e-05 22.8 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CDW59544.1 - 1.7e-08 34.2 0.7 0.29 11.0 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 CDW59544.1 - 1e-06 28.7 0.4 0.27 11.3 0.1 3.5 3 0 0 3 3 3 3 NusA-like KH domain NAD_binding_6 PF08030.12 CDW59545.1 - 2.3e-28 99.3 0.0 5.9e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CDW59545.1 - 8.4e-17 61.2 0.0 6.5e-15 55.2 0.0 2.5 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 CDW59545.1 - 1.2e-16 60.9 8.9 3.5e-16 59.4 8.9 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component EF-hand_7 PF13499.6 CDW59545.1 - 0.00083 19.8 1.6 0.049 14.1 0.0 3.9 3 1 2 5 5 5 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW59545.1 - 0.075 12.6 0.4 0.8 9.4 0.0 2.9 3 0 0 3 3 3 0 EF hand DUF5436 PF17504.2 CDW59545.1 - 0.27 11.6 4.5 0.9 9.9 4.5 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5436) Phage_holin_3_6 PF07332.11 CDW59545.1 - 2 8.5 3.7 2.2 8.4 0.5 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III KH_1 PF00013.29 CDW59546.1 - 8.6e-15 54.3 2.6 5.1e-09 35.8 0.7 2.7 2 0 0 2 2 2 2 KH domain KH_4 PF13083.6 CDW59546.1 - 0.015 15.2 0.1 4.9 7.1 0.0 2.8 2 0 0 2 2 2 0 KH domain DUF2514 PF10721.9 CDW59546.1 - 0.029 14.4 4.5 0.036 14.1 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) MOEP19 PF16005.5 CDW59546.1 - 0.078 13.0 0.1 0.6 10.1 0.0 2.4 3 0 0 3 3 3 0 KH-like RNA-binding domain Ribosomal_L7Ae PF01248.26 CDW59547.1 - 7.1e-23 80.2 0.1 1.5e-22 79.1 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hist_deacetyl PF00850.19 CDW59548.1 - 4.7e-54 183.9 0.1 8.5e-54 183.1 0.1 1.3 1 0 0 1 1 1 1 Histone deacetylase domain tRNA_U5-meth_tr PF05958.11 CDW59548.1 - 3.7e-18 65.6 7.2 3.7e-11 42.6 1.7 2.7 2 1 0 2 2 2 2 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 CDW59548.1 - 5.4e-17 62.3 0.3 5.1e-10 39.9 0.1 2.7 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 CDW59548.1 - 4.5e-13 49.1 0.4 1.1e-07 31.6 0.1 2.3 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_11 PF08241.12 CDW59548.1 - 2.7e-12 47.2 0.2 4.4e-07 30.4 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 CDW59548.1 - 5.8e-12 45.6 1.3 3.8e-09 36.5 0.2 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_32 PF13679.6 CDW59548.1 - 5e-09 36.3 0.9 3.2e-05 24.0 0.1 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_15 PF09445.10 CDW59548.1 - 1.9e-08 34.1 1.6 9.2e-06 25.3 0.2 2.5 2 0 0 2 2 2 2 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 CDW59548.1 - 3.4e-07 30.1 0.2 0.00079 19.1 0.0 2.3 2 0 0 2 2 2 2 Conserved hypothetical protein 95 PrmA PF06325.13 CDW59548.1 - 7.4e-07 28.8 0.5 2.8e-05 23.7 0.2 2.2 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 CDW59548.1 - 1.7e-05 24.7 0.1 0.00021 21.1 0.0 2.4 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_23 PF13489.6 CDW59548.1 - 3.1e-05 23.9 0.1 0.0047 16.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW59548.1 - 4.1e-05 23.6 0.5 0.018 15.0 0.1 2.5 2 0 0 2 2 2 1 Methyltransferase domain MethyltransfD12 PF02086.15 CDW59548.1 - 8.4e-05 22.4 0.9 0.00022 21.0 0.1 1.9 2 0 0 2 2 2 1 D12 class N6 adenine-specific DNA methyltransferase Ubie_methyltran PF01209.18 CDW59548.1 - 0.00028 20.3 0.4 0.011 15.1 0.1 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family N6_N4_Mtase PF01555.18 CDW59548.1 - 0.00038 20.2 0.0 0.00083 19.1 0.0 1.5 1 0 0 1 1 1 1 DNA methylase Methyltransf_4 PF02390.17 CDW59548.1 - 0.00065 19.2 1.8 0.1 12.1 0.2 2.3 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_12 PF08242.12 CDW59548.1 - 0.00072 20.3 0.2 0.003 18.3 0.1 2.1 2 0 0 2 2 1 1 Methyltransferase domain RIC1 PF07064.13 CDW59548.1 - 0.0018 17.7 0.0 0.25 10.7 0.0 2.2 2 0 0 2 2 2 1 RIC1 NodS PF05401.11 CDW59548.1 - 0.0047 16.6 0.4 0.54 9.8 0.0 2.3 2 0 0 2 2 2 1 Nodulation protein S (NodS) TPMT PF05724.11 CDW59548.1 - 0.0076 15.9 0.2 0.5 10.0 0.0 2.3 2 0 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) PCMT PF01135.19 CDW59548.1 - 0.027 14.2 0.1 0.32 10.7 0.0 2.3 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 CDW59548.1 - 0.045 13.4 1.0 1.3 8.7 1.0 2.3 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 CMAS PF02353.20 CDW59548.1 - 0.047 13.0 0.0 0.48 9.7 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase AviRa PF11599.8 CDW59548.1 - 0.14 11.6 3.5 0.2 11.1 0.3 2.1 2 0 0 2 2 2 0 RRNA methyltransferase AviRa TehB PF03848.14 CDW59548.1 - 0.15 11.5 1.4 0.41 10.0 0.1 2.1 2 0 0 2 2 2 0 Tellurite resistance protein TehB Rhodanese PF00581.20 CDW59549.1 - 1.7e-12 47.8 0.0 3.4e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain SLC12 PF03522.15 CDW59551.1 - 4.8e-130 434.4 0.5 4.8e-130 434.4 0.5 2.1 2 0 0 2 2 2 1 Solute carrier family 12 AA_permease PF00324.21 CDW59551.1 - 5.9e-88 295.6 33.1 7.6e-88 295.2 33.1 1.1 1 0 0 1 1 1 1 Amino acid permease ACR_tran PF00873.19 CDW59552.1 - 4.8e-287 954.8 15.2 5.4e-287 954.6 15.2 1.0 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 CDW59552.1 - 1.5e-06 27.4 12.0 1.5e-06 27.4 12.0 2.1 2 0 0 2 2 2 1 MMPL family SecD_SecF PF02355.16 CDW59552.1 - 0.00012 21.6 14.1 0.00025 20.5 14.1 1.5 1 0 0 1 1 1 1 Protein export membrane protein Patched PF02460.18 CDW59552.1 - 1.2 7.1 12.0 1.9 6.5 12.0 1.2 1 0 0 1 1 1 0 Patched family HlyD_D23 PF16576.5 CDW59553.1 - 6.6e-18 64.7 1.6 2.9e-17 62.6 1.7 2.0 1 1 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD PF00529.20 CDW59553.1 - 7.9e-10 38.5 0.0 1.2e-09 37.9 0.0 1.4 1 1 0 1 1 1 1 HlyD membrane-fusion protein of T1SS Biotin_lipoyl_2 PF13533.6 CDW59553.1 - 5.1e-09 35.8 1.0 2e-08 34.0 0.1 2.4 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CDW59553.1 - 8e-08 32.9 3.9 4.3e-05 24.2 0.8 3.2 2 1 0 2 2 2 2 HlyD family secretion protein IL17_R_N PF15037.6 CDW59553.1 - 0.17 10.8 0.1 0.24 10.3 0.1 1.2 1 0 0 1 1 1 0 Interleukin-17 receptor extracellular region OEP PF02321.18 CDW59553.1 - 0.68 9.7 10.0 1.4 8.7 10.0 1.5 1 0 0 1 1 1 0 Outer membrane efflux protein FlgT_C PF16538.5 CDW59553.1 - 8.9 6.9 7.2 2 9.0 0.6 3.0 3 1 0 3 3 3 0 Flagellar assembly protein T, C-terminal domain DUF308 PF03729.13 CDW59554.1 - 2.5e-18 66.1 38.0 5.9e-12 45.7 14.0 3.1 1 1 2 3 3 3 2 Short repeat of unknown function (DUF308) SirB PF04247.12 CDW59554.1 - 0.00074 19.6 3.8 0.00074 19.6 3.8 2.6 2 1 1 3 3 3 1 Invasion gene expression up-regulator, SirB DUF1345 PF07077.11 CDW59554.1 - 0.46 10.2 9.1 0.097 12.4 1.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) Oxidored_q2 PF00420.24 CDW59554.1 - 1.2 8.8 20.5 1.1 8.9 1.1 2.6 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Peptidase_U4 PF03419.13 CDW59554.1 - 1.9 7.7 16.3 2.5 7.3 16.0 1.4 1 1 0 1 1 1 0 Sporulation factor SpoIIGA ATP1G1_PLM_MAT8 PF02038.16 CDW59554.1 - 2.3 7.7 15.8 5.4 6.5 0.1 3.8 4 0 0 4 4 4 0 ATP1G1/PLM/MAT8 family DUF2157 PF09925.9 CDW59554.1 - 2.5 7.9 21.4 1e+02 2.6 21.4 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF2964 PF11177.8 CDW59554.1 - 8 6.7 12.2 0.12 12.6 1.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2964) HdeA PF06411.11 CDW59555.1 - 5.4e-26 90.6 0.3 6.5e-26 90.4 0.3 1.1 1 0 0 1 1 1 1 HdeA/HdeB family MgtC PF02308.16 CDW59556.1 - 3.7e-37 127.4 11.3 5.4e-37 126.8 11.3 1.2 1 0 0 1 1 1 1 MgtC family ArsB PF02040.15 CDW59557.1 - 2.3e-159 531.3 35.0 2.7e-159 531.0 35.0 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein CitMHS PF03600.16 CDW59557.1 - 5.9e-24 84.8 44.4 5.9e-24 84.8 44.4 2.0 1 1 1 2 2 2 1 Citrate transporter HTH_5 PF01022.20 CDW59557.1 - 1.5e-16 60.0 1.8 4e-16 58.6 1.8 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 CDW59557.1 - 4.6e-09 36.2 0.3 9.3e-09 35.2 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 CDW59557.1 - 0.019 15.0 0.0 0.11 12.5 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix Na_sulph_symp PF00939.19 CDW59557.1 - 0.019 14.0 41.8 0.077 12.0 22.1 2.3 1 1 1 2 2 2 0 Sodium:sulfate symporter transmembrane region Pyr_redox_2 PF07992.14 CDW59558.1 - 3.6e-69 233.2 1.7 3.6e-69 233.2 1.7 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CDW59558.1 - 8.5e-37 125.8 1.1 1.1e-35 122.2 0.4 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CDW59558.1 - 2.7e-18 66.3 1.5 4.5e-18 65.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW59558.1 - 9.2e-16 58.0 2.9 5.8e-15 55.3 2.9 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CDW59558.1 - 0.00041 19.6 1.2 0.0081 15.3 0.1 2.4 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 CDW59558.1 - 0.0097 14.7 0.6 8.8 4.9 0.6 3.0 3 0 0 3 3 3 2 HI0933-like protein AlaDh_PNT_C PF01262.21 CDW59558.1 - 0.014 14.7 0.9 0.16 11.3 0.0 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CDW59558.1 - 0.022 13.8 4.7 0.84 8.6 0.1 2.6 3 0 0 3 3 3 0 FAD binding domain FAD_oxidored PF12831.7 CDW59558.1 - 0.031 13.6 0.1 0.13 11.5 0.1 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase PsaF PF17550.2 CDW59558.1 - 0.051 13.1 0.0 3 7.3 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function K_oxygenase PF13434.6 CDW59558.1 - 0.16 11.1 0.0 0.32 10.1 0.0 1.5 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) RsmJ PF04378.13 CDW59559.1 - 4e-119 396.3 0.0 4.7e-119 396.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA large subunit methyltransferase D, RlmJ Cons_hypoth95 PF03602.15 CDW59559.1 - 0.0019 17.9 0.0 0.12 12.0 0.0 2.5 3 0 0 3 3 3 2 Conserved hypothetical protein 95 Peptidase_M3 PF01432.20 CDW59560.1 - 4.3e-171 570.2 0.0 5.8e-171 569.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 PTR2 PF00854.21 CDW59561.1 - 5.3e-99 331.7 19.6 7.7e-99 331.2 19.6 1.2 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 CDW59561.1 - 4.4e-14 52.2 58.1 1.1e-10 41.0 30.9 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily Ldr_toxin PF13940.6 CDW59561.1 - 0.14 12.2 0.2 0.14 12.2 0.2 2.4 3 0 0 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system Pkinase PF00069.25 CDW59562.1 - 7.6e-35 120.5 0.0 1.1e-34 120.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59562.1 - 6.2e-20 71.6 0.0 8.5e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW59562.1 - 4.5e-07 29.5 0.0 1.6e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW59562.1 - 3.8e-05 22.8 0.0 6.6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CDW59562.1 - 0.0092 15.4 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW59562.1 - 0.02 14.8 0.1 0.079 12.9 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Bap31 PF05529.12 CDW59563.1 - 8.3e-23 80.7 5.3 4.3e-16 59.0 0.1 2.0 1 1 1 2 2 2 2 Bap31/Bap29 transmembrane region UQ_con PF00179.26 CDW59564.1 - 6.5e-47 158.7 0.0 8e-47 158.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CDW59564.1 - 0.0033 17.1 0.0 0.0042 16.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CDW59564.1 - 0.0097 15.8 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 CDW59564.1 - 0.068 13.4 0.1 0.12 12.7 0.1 1.5 1 1 0 1 1 1 0 RWD domain ERCC4 PF02732.15 CDW59565.1 - 1.4e-15 57.8 0.0 2.8e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain Pyridoxal_deC PF00282.19 CDW59566.1 - 5.1e-19 68.2 0.0 8e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CDW59566.1 - 1.5e-05 24.2 0.0 0.0012 17.9 0.0 2.9 1 1 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CDW59566.1 - 0.0056 16.0 0.0 0.0093 15.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase FemAB_like PF04339.12 CDW59567.1 - 0.25 10.4 0.0 0.29 10.2 0.0 1.0 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition zf-C3HC4_2 PF13923.6 CDW59568.1 - 1.2e-15 57.0 10.8 2e-15 56.3 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW59568.1 - 9.6e-10 38.2 11.1 1.6e-09 37.5 11.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW59568.1 - 1.8e-09 37.8 9.4 2.9e-09 37.1 9.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDW59568.1 - 2.5e-08 33.7 8.2 3.7e-08 33.1 8.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RAWUL PF16207.5 CDW59568.1 - 6.9e-08 33.0 0.0 1.7e-07 31.8 0.0 1.7 1 1 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-RING_UBOX PF13445.6 CDW59568.1 - 4.6e-06 26.6 8.6 9e-06 25.6 8.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDW59568.1 - 6.3e-06 26.1 9.3 1.1e-05 25.3 9.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CDW59568.1 - 1.4e-05 25.2 7.9 2.5e-05 24.3 7.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 CDW59568.1 - 3.8e-05 23.4 4.9 7.6e-05 22.5 4.9 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 CDW59568.1 - 0.00021 21.1 3.7 0.00037 20.3 3.7 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 CDW59568.1 - 0.00059 19.6 6.7 0.0015 18.3 6.7 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CDW59568.1 - 0.00098 19.4 7.9 0.0029 17.8 7.9 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-UDP PF14569.6 CDW59568.1 - 0.004 17.2 2.1 0.0095 16.0 2.1 1.6 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-C3HC4_5 PF17121.5 CDW59568.1 - 0.022 14.7 7.9 0.072 13.0 7.9 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW59568.1 - 0.062 13.2 9.0 0.72 9.8 9.4 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C4_Topoisom PF01396.19 CDW59568.1 - 0.18 11.6 2.5 0.14 12.0 0.5 1.8 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-RING_10 PF16685.5 CDW59568.1 - 0.39 10.9 7.1 0.75 10.0 7.1 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 CDW59568.1 - 1 9.2 4.6 2.5 7.9 4.6 1.7 1 0 0 1 1 1 0 RING-like zinc finger DZR PF12773.7 CDW59568.1 - 1.5 9.0 7.8 3.9 7.6 5.0 2.3 1 1 1 2 2 2 0 Double zinc ribbon AAA PF00004.29 CDW59569.1 - 1e-18 68.0 0.3 5.6e-18 65.7 0.3 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CDW59569.1 - 8.8e-07 28.8 0.0 1.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 CDW59569.1 - 0.00037 20.2 0.0 0.0047 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 CDW59569.1 - 0.011 15.7 0.1 0.14 12.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW59569.1 - 0.018 15.4 0.0 0.05 14.0 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 CDW59569.1 - 0.04 13.8 0.0 0.084 12.8 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 CDW59569.1 - 0.047 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 CDW59569.1 - 0.053 12.9 0.0 0.29 10.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 CDW59569.1 - 0.076 12.4 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATP-synt_G PF04718.15 CDW59570.1 - 5.7e-10 39.9 2.5 1.7e-09 38.4 2.5 1.8 1 1 0 1 1 1 1 Mitochondrial ATP synthase g subunit Strabismus PF06638.11 CDW59572.1 - 5e-168 559.9 0.4 5.6e-168 559.7 0.4 1.0 1 0 0 1 1 1 1 Strabismus protein Per1 PF04080.13 CDW59572.1 - 0.14 11.9 4.8 0.22 11.2 4.8 1.3 1 0 0 1 1 1 0 Per1-like family PalH PF08733.10 CDW59572.1 - 5 6.0 9.5 8.4 5.3 9.5 1.2 1 0 0 1 1 1 0 PalH/RIM21 Pkinase_Tyr PF07714.17 CDW59574.1 - 7.5e-67 225.3 0.0 9.9e-67 224.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW59574.1 - 1.9e-33 115.9 0.0 2.6e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW59574.1 - 3e-07 30.5 0.0 1.1e-06 28.7 0.0 1.9 2 0 0 2 2 2 1 SH2 domain Kinase-like PF14531.6 CDW59574.1 - 0.067 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like POR_N PF01855.19 CDW59575.1 - 6e-48 163.6 1.3 2.4e-27 96.2 0.5 2.3 1 1 1 2 2 2 2 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Fer4_20 PF14691.6 CDW59575.1 - 2.4e-40 136.8 1.6 3.1e-40 136.5 0.3 1.9 2 0 0 2 2 2 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 CDW59575.1 - 1.7e-33 116.1 1.1 8e-33 113.9 1.4 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase POR PF01558.18 CDW59575.1 - 1.1e-28 100.5 0.0 2.1e-28 99.6 0.0 1.5 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 CDW59575.1 - 1.2e-18 67.3 0.0 3.8e-18 65.7 0.0 2.0 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II EKR PF10371.9 CDW59575.1 - 3.8e-16 58.6 0.1 9.2e-15 54.2 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function Pyr_redox PF00070.27 CDW59575.1 - 3.2e-12 46.8 2.7 2e-05 25.0 0.0 4.1 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW59575.1 - 5.2e-12 45.6 0.6 7.2e-08 32.0 0.0 3.3 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW59575.1 - 1.6e-07 31.4 0.7 7.1e-07 29.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CDW59575.1 - 2.9e-07 30.0 0.2 0.00088 18.6 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CDW59575.1 - 1.6e-05 24.3 3.1 0.00093 18.5 0.1 3.0 3 0 0 3 3 3 1 Thi4 family FAD_oxidored PF12831.7 CDW59575.1 - 0.00034 20.1 2.7 0.088 12.1 0.1 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 CDW59575.1 - 0.00039 20.8 3.5 0.06 13.8 0.2 3.0 2 1 1 3 3 3 1 Putative NAD(P)-binding HI0933_like PF03486.14 CDW59575.1 - 0.0018 17.0 1.8 0.009 14.8 0.1 2.3 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CDW59575.1 - 0.0051 16.4 0.9 0.0051 16.4 0.9 3.2 3 1 0 4 4 4 1 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 CDW59575.1 - 0.0059 16.0 0.0 2.3 7.5 0.0 2.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 CDW59575.1 - 0.0085 15.2 3.7 0.048 12.7 0.3 2.3 2 0 0 2 2 2 1 FAD binding domain Transketolase_C PF02780.20 CDW59575.1 - 0.01 15.7 0.0 0.68 9.8 0.0 2.8 2 0 0 2 2 2 0 Transketolase, C-terminal domain FAD_binding_3 PF01494.19 CDW59575.1 - 0.011 15.0 0.8 0.018 14.3 0.1 1.6 2 0 0 2 2 2 0 FAD binding domain K_oxygenase PF13434.6 CDW59575.1 - 0.013 14.7 0.0 1.6 7.7 0.0 2.4 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) F420_oxidored PF03807.17 CDW59575.1 - 0.02 15.5 0.2 1.1 9.9 0.0 2.9 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent Amino_oxidase PF01593.24 CDW59575.1 - 0.024 14.0 0.4 0.064 12.5 0.1 1.9 2 1 1 3 3 3 0 Flavin containing amine oxidoreductase GIDA PF01134.22 CDW59575.1 - 0.024 13.7 1.4 1.3 8.0 0.0 2.7 3 0 0 3 3 3 0 Glucose inhibited division protein A XFP PF03894.15 CDW59575.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Shikimate_DH PF01488.20 CDW59575.1 - 0.27 11.3 1.3 2.7 8.1 0.0 3.4 4 0 0 4 4 3 0 Shikimate / quinate 5-dehydrogenase dCMP_cyt_deam_1 PF00383.23 CDW59576.1 - 2.7e-23 81.8 1.5 4.5e-23 81.0 1.5 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDW59576.1 - 1.8e-13 50.4 0.6 3.2e-13 49.6 0.6 1.4 1 0 0 1 1 1 1 MafB19-like deaminase Lactamase_B PF00753.27 CDW59576.1 - 5.5e-13 49.4 0.0 7e-12 45.8 0.0 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDW59576.1 - 9.6e-05 22.0 0.0 0.00019 21.0 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain APOBEC3 PF18771.1 CDW59576.1 - 0.028 14.5 0.2 0.35 11.0 0.1 2.4 2 0 0 2 2 2 0 APOBEC3 HHH_3 PF12836.7 CDW59577.1 - 8e-24 83.7 0.2 2e-23 82.4 0.2 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif SLBB PF10531.9 CDW59577.1 - 5.4e-14 51.8 0.0 1.3e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 SLBB domain CTP_transf_like PF01467.26 CDW59577.1 - 1.7e-12 47.8 0.6 1e-11 45.2 0.2 2.3 2 0 0 2 2 2 1 Cytidylyltransferase-like HHH PF00633.23 CDW59577.1 - 2e-12 46.3 0.1 2.7e-05 23.8 0.0 2.8 2 0 0 2 2 2 2 Helix-hairpin-helix motif PDZ_2 PF13180.6 CDW59577.1 - 4.1e-12 46.3 0.4 2.4e-11 43.8 0.1 2.4 2 0 0 2 2 2 1 PDZ domain HHH_5 PF14520.6 CDW59577.1 - 4.5e-07 30.4 1.2 0.075 13.6 0.0 3.9 4 0 0 4 4 4 2 Helix-hairpin-helix domain HHH_6 PF14579.6 CDW59577.1 - 1.7e-05 25.0 0.1 0.00014 22.1 0.1 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif Lon_C PF05362.13 CDW59577.1 - 2e-05 24.2 0.8 4.3e-05 23.2 0.8 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain Citrate_ly_lig PF08218.11 CDW59577.1 - 0.0011 18.7 0.1 0.0021 17.8 0.1 1.5 1 0 0 1 1 1 1 Citrate lyase ligase C-terminal domain HHH_2 PF12826.7 CDW59577.1 - 0.0026 17.8 1.3 0.34 11.1 0.0 3.2 2 1 1 3 3 3 1 Helix-hairpin-helix motif T2SSK PF03934.13 CDW59577.1 - 0.0048 16.3 0.0 0.009 15.4 0.0 1.4 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein K PsbU PF06514.11 CDW59577.1 - 0.013 15.5 0.0 0.045 13.7 0.0 1.9 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) DUF1344 PF07076.11 CDW59577.1 - 0.015 15.2 0.5 0.051 13.5 0.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) PDZ_1 PF12812.7 CDW59577.1 - 0.088 12.8 0.2 0.36 10.9 0.1 2.1 2 0 0 2 2 2 0 PDZ-like domain Cons_hypoth95 PF03602.15 CDW59578.1 - 5.6e-44 149.9 0.0 6.3e-44 149.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 CDW59578.1 - 3.8e-07 29.8 0.0 4.8e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 CDW59578.1 - 0.0002 22.4 0.0 0.00026 22.0 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 CDW59578.1 - 0.0034 17.0 0.0 0.0043 16.6 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase N6-adenineMlase PF10237.9 CDW59578.1 - 0.0052 16.6 0.0 0.006 16.4 0.0 1.2 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Methyltransf_31 PF13847.6 CDW59578.1 - 0.0058 16.4 0.0 0.0073 16.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CDW59578.1 - 0.0067 16.2 0.0 0.0087 15.8 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase RsmJ PF04378.13 CDW59578.1 - 0.0075 15.5 0.0 0.009 15.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA large subunit methyltransferase D, RlmJ TRM PF02005.16 CDW59578.1 - 0.011 14.9 0.0 0.013 14.7 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase N6_N4_Mtase PF01555.18 CDW59578.1 - 0.018 14.8 0.0 0.3 10.8 0.0 2.0 2 0 0 2 2 2 0 DNA methylase MethyltransfD12 PF02086.15 CDW59578.1 - 0.018 14.7 0.1 3.6 7.2 0.1 2.2 1 1 1 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase PrmA PF06325.13 CDW59578.1 - 0.022 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 CDW59578.1 - 0.04 13.6 0.1 0.18 11.5 0.1 1.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 AAA_31 PF13614.6 CDW59578.1 - 0.074 13.0 0.3 0.13 12.2 0.2 1.2 1 1 0 1 1 1 0 AAA domain DUF2129 PF09902.9 CDW59579.1 - 1.8e-14 53.5 1.2 2.7e-14 53.0 1.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2129) Peptidase_S8_N PF16361.5 CDW59579.1 - 0.18 12.3 1.4 3.3 8.2 0.2 1.9 1 1 1 2 2 2 0 N-terminal of Subtilase family CPSase_L_D2 PF02786.17 CDW59580.1 - 3.5e-79 265.2 0.3 7.5e-79 264.1 0.3 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 CDW59580.1 - 3.5e-74 248.8 0.3 5.9e-74 248.1 0.3 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 CDW59580.1 - 5.7e-41 139.5 0.0 1.2e-40 138.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDW59580.1 - 9.3e-34 115.8 0.0 2e-33 114.7 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 CDW59580.1 - 6e-27 94.9 0.0 1.7e-26 93.4 0.0 1.8 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 CDW59580.1 - 4e-18 65.0 0.8 1e-17 63.7 0.8 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 CDW59580.1 - 6.8e-10 38.8 0.4 1.6e-09 37.6 0.4 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 CDW59580.1 - 2e-09 37.1 0.1 0.0014 18.4 0.1 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 CDW59580.1 - 3.1e-08 33.4 0.1 7.3e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CDW59580.1 - 3.5e-07 30.4 0.1 7.5e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 CDW59580.1 - 0.00024 20.4 0.1 0.38 9.9 0.1 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_Ter PF15632.6 CDW59580.1 - 0.00095 18.9 0.3 0.0032 17.2 0.1 2.0 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon RnfC_N PF13375.6 CDW59580.1 - 0.0013 18.7 0.3 0.004 17.1 0.1 2.0 2 0 0 2 2 1 1 RnfC Barrel sandwich hybrid domain PTS_EIIA_1 PF00358.20 CDW59580.1 - 0.0051 16.6 0.1 0.62 9.8 0.1 2.8 1 1 1 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 HlyD_3 PF13437.6 CDW59580.1 - 0.042 14.5 0.0 3.6 8.3 0.0 2.8 2 0 0 2 2 2 0 HlyD family secretion protein ATPgrasp_ST PF14397.6 CDW59580.1 - 0.054 12.7 0.0 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp NQRA PF05896.11 CDW59580.1 - 0.087 12.2 0.2 0.2 11.1 0.2 1.6 1 1 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ADH_zinc_N PF00107.26 CDW59580.1 - 0.1 12.6 0.0 0.47 10.4 0.0 2.1 2 0 0 2 2 2 0 Zinc-binding dehydrogenase DUF1507 PF07408.11 CDW59581.1 - 1.3e-35 121.1 0.5 1.5e-35 120.9 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1507) Pro_isomerase PF00160.21 CDW59582.1 - 3.2e-48 164.0 0.1 3.7e-48 163.8 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Filament PF00038.21 CDW59583.1 - 8.7e-36 124.1 46.2 1.8e-33 116.4 46.1 2.8 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 CDW59583.1 - 2.2e-11 44.1 0.0 4.3e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Lamin Tail Domain GBR2_CC PF18455.1 CDW59583.1 - 0.57 10.3 5.5 1.3 9.2 0.3 3.6 3 0 0 3 3 3 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain RMI2 PF16100.5 CDW59584.1 - 2.5e-07 30.6 0.0 3e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 Peptidase_A17 PF05380.13 CDW59585.1 - 0.0017 18.4 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase Histone PF00125.24 CDW59586.1 - 4.5e-33 114.4 1.1 4.5e-33 114.4 1.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59586.1 - 0.00027 21.1 0.6 0.00056 20.1 0.0 1.9 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 CDW59586.1 - 0.00042 20.4 0.0 0.00065 19.8 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW59586.1 - 0.0055 17.1 0.0 0.012 16.0 0.0 1.6 2 0 0 2 2 2 1 CENP-S protein TFIID-31kDa PF02291.15 CDW59586.1 - 0.043 13.9 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CDW59586.1 - 0.071 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated CEBP_ZZ PF16366.5 CDW59587.1 - 3.4e-13 49.6 3.7 7.2e-13 48.6 3.7 1.6 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_7 PF16367.5 CDW59587.1 - 4.5e-09 36.3 0.5 1.8e-05 24.8 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif RRM_1 PF00076.22 CDW59587.1 - 0.00061 19.6 0.0 0.024 14.4 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spo7_2_N PF15407.6 CDW59587.1 - 0.16 11.6 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 0 Sporulation protein family 7 Sigma70_r2 PF04542.14 CDW59588.1 - 8.3e-09 35.1 0.0 1.5e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 Sigma-70 region 2 Sigma70_r4_2 PF08281.12 CDW59588.1 - 3.6e-06 26.5 0.2 0.00039 20.0 0.0 2.4 1 1 1 2 2 2 2 Sigma-70, region 4 MFS_1 PF07690.16 CDW59589.1 - 7.5e-26 90.9 63.4 2e-22 79.6 40.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CDW59589.1 - 0.00015 20.2 8.4 0.00015 20.2 8.4 2.0 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 CDW59589.1 - 0.16 10.5 36.3 0.0047 15.5 27.4 2.0 1 1 1 2 2 2 0 MFS/sugar transport protein Peptidase_M20 PF01546.28 CDW59590.1 - 3.4e-26 92.2 0.1 4.7e-26 91.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CDW59590.1 - 5.5e-14 52.0 0.0 1.1e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Dak2 PF02734.17 CDW59591.1 - 3e-42 144.5 6.2 7.1e-42 143.3 2.0 2.3 2 0 0 2 2 2 1 DAK2 domain EIIA-man PF03610.16 CDW59591.1 - 1.1e-17 64.3 1.2 1.1e-17 64.3 1.2 2.0 2 0 0 2 2 2 1 PTS system fructose IIA component DUF413 PF04219.12 CDW59591.1 - 0.037 14.1 0.1 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF Dak1 PF02733.17 CDW59592.1 - 2.5e-119 397.8 1.8 2.9e-119 397.6 1.8 1.1 1 0 0 1 1 1 1 Dak1 domain MIP PF00230.20 CDW59593.1 - 1.2e-45 156.0 14.2 1.3e-45 155.8 14.2 1.0 1 0 0 1 1 1 1 Major intrinsic protein Na_Pi_cotrans PF02690.15 CDW59593.1 - 0.041 14.0 9.0 0.025 14.7 5.6 2.2 1 1 1 2 2 2 0 Na+/Pi-cotransporter FGGY_N PF00370.21 CDW59594.1 - 6.8e-87 291.1 0.6 9e-87 290.7 0.6 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 CDW59594.1 - 1.5e-63 214.1 0.1 2.7e-63 213.3 0.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDE_Tnp_ISAZ013 PF07592.11 CDW59594.1 - 0.037 13.0 0.0 0.08 11.9 0.0 1.5 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain DAO PF01266.24 CDW59595.1 - 1.1e-58 199.5 0.0 1.5e-58 199.1 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 CDW59595.1 - 3e-16 59.4 0.1 5.6e-16 58.6 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 CDW59595.1 - 5.1e-07 29.1 2.5 0.0026 16.9 1.2 2.3 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.19 CDW59595.1 - 4.8e-05 22.8 0.9 0.00029 20.2 0.9 1.9 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CDW59595.1 - 0.00011 21.7 0.1 0.0002 20.9 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CDW59595.1 - 0.00016 20.9 2.9 0.011 14.9 1.1 2.4 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 CDW59595.1 - 0.0018 17.6 0.5 0.0057 15.9 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW59595.1 - 0.0036 17.5 0.5 0.012 15.8 0.5 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CDW59595.1 - 0.02 15.4 2.5 0.53 10.9 0.3 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CDW59595.1 - 0.025 14.5 0.3 0.075 12.9 0.3 1.9 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CDW59595.1 - 0.049 12.7 1.0 0.36 9.8 0.4 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 CDW59595.1 - 0.051 12.8 1.6 6.1 6.0 0.1 2.3 2 0 0 2 2 2 0 Thi4 family Trp_halogenase PF04820.14 CDW59595.1 - 0.062 12.1 1.2 0.54 9.0 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 CDW59595.1 - 0.11 11.1 1.0 0.27 9.9 1.0 1.6 1 0 0 1 1 1 0 HI0933-like protein Cecropin PF00272.19 CDW59595.1 - 0.14 11.9 1.1 0.34 10.6 1.1 1.7 1 0 0 1 1 1 0 Cecropin family Response_reg PF00072.24 CDW59596.1 - 1.2e-31 109.1 0.2 2.9e-31 107.9 0.3 1.5 2 0 0 2 2 2 1 Response regulator receiver domain Trans_reg_C PF00486.28 CDW59596.1 - 5.8e-16 58.3 0.0 1.8e-15 56.7 0.0 1.8 1 0 0 1 1 1 1 Transcriptional regulatory protein, C terminal MgsA_C PF12002.8 CDW59597.1 - 4.2e-64 215.5 0.1 7.6e-64 214.7 0.1 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 CDW59597.1 - 3.3e-27 94.6 0.4 8.5e-27 93.3 0.4 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 CDW59597.1 - 1e-17 64.8 0.0 2.3e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDW59597.1 - 6.3e-15 55.3 0.0 1.1e-14 54.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDW59597.1 - 2.7e-07 30.7 0.3 1.3e-05 25.2 0.0 3.0 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CDW59597.1 - 2.5e-06 27.5 0.0 6.6e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CDW59597.1 - 2.2e-05 24.2 0.0 0.087 12.5 0.0 2.3 1 1 1 2 2 2 2 Sigma-54 interaction domain AAA_2 PF07724.14 CDW59597.1 - 4.6e-05 23.6 0.0 9e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CDW59597.1 - 6.8e-05 23.2 0.1 0.0096 16.2 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 CDW59597.1 - 0.00012 22.5 0.0 0.012 16.0 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CDW59597.1 - 0.00019 20.9 0.0 0.026 13.9 0.0 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 CDW59597.1 - 0.00031 20.3 0.1 0.00076 19.0 0.0 1.6 2 0 0 2 2 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 CDW59597.1 - 0.00037 20.8 0.0 0.0008 19.8 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 CDW59597.1 - 0.00057 19.1 0.0 0.0079 15.4 0.0 2.4 1 1 1 2 2 2 1 NB-ARC domain DNA_pol3_delta2 PF13177.6 CDW59597.1 - 0.00058 19.7 0.0 0.98 9.2 0.0 2.4 1 1 1 2 2 2 2 DNA polymerase III, delta subunit SKI PF01202.22 CDW59597.1 - 0.0014 18.8 0.0 0.047 13.8 0.0 2.4 1 1 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 CDW59597.1 - 0.0017 18.9 0.0 0.004 17.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 CDW59597.1 - 0.0024 17.7 0.7 0.0055 16.5 0.7 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_33 PF13671.6 CDW59597.1 - 0.0028 17.8 0.0 0.012 15.8 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 CDW59597.1 - 0.0036 17.1 0.0 0.2 11.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 CDW59597.1 - 0.0036 17.3 1.0 0.85 9.6 0.2 2.7 2 1 1 3 3 2 1 Type III restriction enzyme, res subunit AAA_3 PF07726.11 CDW59597.1 - 0.0066 16.3 0.0 0.022 14.6 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.25 CDW59597.1 - 0.0072 16.0 0.1 0.033 13.8 0.1 2.1 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF815 PF05673.13 CDW59597.1 - 0.0075 15.4 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 CDW59597.1 - 0.0086 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 CDW59597.1 - 0.0091 15.9 0.3 0.086 12.7 0.2 2.7 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea TIP49 PF06068.13 CDW59597.1 - 0.011 15.0 0.0 0.025 13.8 0.0 1.6 2 0 0 2 2 1 0 TIP49 P-loop domain MMR_HSR1 PF01926.23 CDW59597.1 - 0.011 15.8 0.0 0.026 14.6 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Viral_helicase1 PF01443.18 CDW59597.1 - 0.014 15.1 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CPT PF07931.12 CDW59597.1 - 0.017 14.9 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 CDW59597.1 - 0.019 15.3 0.0 4.9 7.5 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_17 PF13207.6 CDW59597.1 - 0.021 15.2 0.0 0.09 13.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW59597.1 - 0.028 14.1 0.0 0.059 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDW59597.1 - 0.03 14.2 0.0 0.084 12.8 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase Sigma54_activ_2 PF14532.6 CDW59597.1 - 0.033 14.3 0.0 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 CDW59597.1 - 0.038 14.5 0.1 0.071 13.6 0.1 1.6 1 1 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 CDW59597.1 - 0.076 12.9 0.1 0.24 11.3 0.0 1.9 1 1 0 1 1 1 0 NTPase NACHT PF05729.12 CDW59597.1 - 0.1 12.5 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 CDW59597.1 - 0.1 12.0 0.2 0.97 8.8 0.0 2.6 2 1 1 3 3 2 0 Bacterial TniB protein Cytidylate_kin PF02224.18 CDW59597.1 - 0.12 12.1 0.1 0.73 9.5 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase AAA_28 PF13521.6 CDW59597.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CDW59597.1 - 0.15 11.6 0.1 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CDW59597.1 - 0.35 10.0 3.0 1 8.5 1.1 2.5 2 1 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) Abhydrolase_3 PF07859.13 CDW59598.1 - 4.8e-64 216.1 0.1 6.1e-64 215.7 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CDW59598.1 - 1.8e-05 23.8 0.0 0.0038 16.2 0.0 2.2 2 0 0 2 2 2 2 Carboxylesterase family Peptidase_S9 PF00326.21 CDW59598.1 - 0.0002 20.9 0.9 0.00065 19.2 0.9 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 CDW59598.1 - 0.00079 18.4 0.0 0.0016 17.4 0.0 1.5 1 1 0 1 1 1 1 Steryl acetyl hydrolase Esterase PF00756.20 CDW59598.1 - 0.0013 18.5 0.1 0.0027 17.4 0.1 1.5 1 1 0 1 1 1 1 Putative esterase AXE1 PF05448.12 CDW59598.1 - 0.0039 15.9 0.0 1.4 7.6 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Lipase_3 PF01764.25 CDW59598.1 - 0.036 13.9 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 CDW59598.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PAF-AH_p_II PF03403.13 CDW59598.1 - 0.14 10.6 0.0 5.8 5.3 0.0 2.1 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF4931 PF16285.5 CDW59599.1 - 6.8e-60 202.4 3.3 1.3e-59 201.5 3.2 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4931) PRD PF00874.20 CDW59599.1 - 1.3e-14 54.2 13.4 2.1e-14 53.6 4.2 3.0 3 1 0 3 3 3 2 PRD domain GalP_UDP_transf PF01087.22 CDW59599.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.6 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.23 CDW59599.1 - 0.055 14.2 0.3 0.42 11.4 0.0 2.5 2 1 0 2 2 2 0 HIT domain Cullin_Nedd8 PF10557.9 CDW59599.1 - 0.47 10.5 5.2 4.3 7.4 1.4 2.5 1 1 1 2 2 2 0 Cullin protein neddylation domain FSH1 PF03959.13 CDW59600.1 - 9.9e-32 110.3 0.0 1.8e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Nas2_N PF18265.1 CDW59600.1 - 1.6e-24 85.6 1.3 3.4e-24 84.6 1.3 1.6 1 0 0 1 1 1 1 Nas2 N_terminal domain Abhydrolase_2 PF02230.16 CDW59600.1 - 3.4e-05 23.8 0.0 0.0001 22.2 0.0 1.8 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase PDZ_6 PF17820.1 CDW59600.1 - 0.00071 19.4 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain EGF_2 PF07974.13 CDW59600.1 - 1.5 9.2 6.8 3.4 8.1 6.8 1.6 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 CDW59600.1 - 1.6 9.1 6.5 4 7.8 6.5 1.8 1 0 0 1 1 1 0 EGF-like domain RNase_J_C PF17770.1 CDW59601.1 - 1.3e-21 77.4 0.0 2.6e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease J C-terminal domain Lactamase_B PF00753.27 CDW59601.1 - 3.4e-16 59.8 0.8 7e-16 58.8 0.8 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 CDW59601.1 - 1.9e-11 43.7 0.1 5.8e-10 39.0 0.0 2.5 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 CDW59601.1 - 1.7e-10 40.8 0.7 3.5e-10 39.7 0.1 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain SIS_2 PF13580.6 CDW59601.1 - 0.073 13.1 0.7 0.48 10.4 0.7 2.2 1 1 0 1 1 1 0 SIS domain DUF4453 PF14627.6 CDW59601.1 - 0.081 13.0 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) Lactamase_B_6 PF16661.5 CDW59601.1 - 0.11 11.9 0.0 0.31 10.4 0.0 1.7 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily domain ABC_membrane PF00664.23 CDW59602.1 - 1.1e-68 231.8 26.0 5.1e-46 157.5 11.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CDW59602.1 - 7e-66 220.9 0.1 1.5e-33 116.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CDW59602.1 - 3.1e-10 39.9 6.4 8.1e-06 25.4 0.0 4.1 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CDW59602.1 - 4.1e-10 39.8 0.0 0.00045 20.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CDW59602.1 - 7.6e-09 36.0 0.1 9.7e-05 22.7 0.0 3.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CDW59602.1 - 2.3e-08 34.6 0.1 0.0099 16.3 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CDW59602.1 - 2.5e-07 30.3 1.0 0.018 14.8 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CDW59602.1 - 1.7e-06 28.1 0.0 0.013 15.6 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 CDW59602.1 - 1.9e-06 27.9 0.9 0.34 10.7 0.0 3.3 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CDW59602.1 - 3.6e-06 26.8 0.7 0.017 14.8 0.1 3.3 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CDW59602.1 - 5.4e-06 27.0 3.2 0.0063 17.0 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_10 PF12846.7 CDW59602.1 - 2.5e-05 23.4 0.1 0.13 11.1 0.0 2.5 2 0 0 2 2 2 2 AAA-like domain NTPase_1 PF03266.15 CDW59602.1 - 3e-05 24.0 0.2 0.0036 17.2 0.0 3.0 3 0 0 3 3 2 1 NTPase T2SSE PF00437.20 CDW59602.1 - 5.8e-05 22.3 0.0 0.018 14.1 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 CDW59602.1 - 6.9e-05 22.4 0.1 0.16 11.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region DUF87 PF01935.17 CDW59602.1 - 8.5e-05 22.8 0.9 0.48 10.5 0.0 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain Zeta_toxin PF06414.12 CDW59602.1 - 9.3e-05 21.8 0.2 0.45 9.8 0.0 3.2 3 0 0 3 3 3 2 Zeta toxin AAA PF00004.29 CDW59602.1 - 0.00016 22.1 0.0 0.059 13.8 0.0 3.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDW59602.1 - 0.00017 21.2 0.0 0.088 12.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 CDW59602.1 - 0.00023 21.1 0.1 0.24 11.4 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_15 PF13175.6 CDW59602.1 - 0.00029 20.7 1.7 0.29 10.8 0.0 3.3 4 0 0 4 4 3 2 AAA ATPase domain AAA_18 PF13238.6 CDW59602.1 - 0.00039 21.0 0.0 0.21 12.2 0.0 2.9 3 0 0 3 3 2 1 AAA domain cobW PF02492.19 CDW59602.1 - 0.00058 19.5 0.1 0.16 11.5 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CDW59602.1 - 0.00065 19.9 0.0 2.1 8.5 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CDW59602.1 - 0.00085 19.3 0.3 2.6 8.1 0.1 3.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CDW59602.1 - 0.00099 19.4 0.1 0.66 10.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDW59602.1 - 0.0012 18.8 0.1 1.7 8.6 0.0 3.0 3 0 0 3 3 2 1 NACHT domain DUF3584 PF12128.8 CDW59602.1 - 0.0014 16.3 0.1 0.66 7.4 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3584) AAA_14 PF13173.6 CDW59602.1 - 0.0021 18.1 0.1 1.4 8.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 CDW59602.1 - 0.0024 17.7 0.7 2.5 7.8 0.6 3.1 2 2 0 2 2 2 1 DEAD/DEAH box helicase ATP_bind_1 PF03029.17 CDW59602.1 - 0.0029 17.4 0.2 1.9 8.2 0.0 2.9 3 0 0 3 3 3 1 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 CDW59602.1 - 0.0034 17.1 0.0 1 9.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CDW59602.1 - 0.0038 17.0 0.1 1.2 8.9 0.0 2.9 3 0 0 3 3 2 1 IstB-like ATP binding protein NB-ARC PF00931.22 CDW59602.1 - 0.0047 16.2 0.1 1.8 7.7 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain SRP54 PF00448.22 CDW59602.1 - 0.007 16.0 0.1 0.97 9.0 0.0 2.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Dynamin_N PF00350.23 CDW59602.1 - 0.01 15.9 0.1 3.2 7.8 0.0 2.7 2 0 0 2 2 2 0 Dynamin family Roc PF08477.13 CDW59602.1 - 0.014 15.6 0.1 2.8 8.2 0.0 2.9 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 CDW59602.1 - 0.015 14.7 0.2 5.6 6.2 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family PduV-EutP PF10662.9 CDW59602.1 - 0.02 14.6 0.1 8.1 6.2 0.0 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 CDW59602.1 - 0.022 15.1 0.0 5.2 7.5 0.0 2.9 2 0 0 2 2 2 0 RNA helicase ATP-synt_ab PF00006.25 CDW59602.1 - 0.023 14.3 0.4 2.6 7.7 0.0 2.4 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Septin PF00735.18 CDW59602.1 - 0.031 13.6 0.0 0.56 9.4 0.0 2.3 2 0 0 2 2 2 0 Septin AAA_19 PF13245.6 CDW59602.1 - 0.045 14.1 0.6 7.4 6.9 0.0 3.0 3 0 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 CDW59602.1 - 0.05 12.5 0.2 2.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Mg_chelatase PF01078.21 CDW59602.1 - 0.059 12.7 0.0 5.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ResIII PF04851.15 CDW59602.1 - 0.1 12.6 0.0 5.6 6.9 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF5602 PF18197.1 CDW59602.1 - 0.11 13.0 0.1 0.31 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5602) MobB PF03205.14 CDW59602.1 - 0.12 12.3 0.2 5.6 6.9 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.6 CDW59602.1 - 0.12 12.8 0.0 12 6.4 0.0 3.0 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 CDW59602.1 - 0.12 12.2 0.0 2.8 7.7 0.0 2.5 3 0 0 3 3 2 0 Deoxynucleoside kinase APS_kinase PF01583.20 CDW59602.1 - 0.15 11.9 0.1 9.1 6.1 0.0 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase SbcCD_C PF13558.6 CDW59602.1 - 0.31 11.3 3.2 49 4.2 0.1 3.8 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Hexapep PF00132.24 CDW59603.1 - 2.8e-16 58.5 7.8 2.9e-09 36.3 0.4 3.9 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDW59603.1 - 0.00011 21.9 10.6 0.044 13.5 0.1 3.4 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Ciart PF15673.5 CDW59603.1 - 0.051 13.0 0.0 0.057 12.8 0.0 1.1 1 0 0 1 1 1 0 Circadian-associated transcriptional repressor TPR_17 PF13431.6 CDW59603.1 - 0.087 13.2 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Fucokinase PF07959.12 CDW59603.1 - 0.13 11.2 0.1 0.21 10.5 0.1 1.4 1 1 0 1 1 1 0 L-fucokinase ATP-synt_B PF00430.18 CDW59604.1 - 6e-39 133.1 13.3 6e-39 133.1 13.3 1.7 2 0 0 2 2 2 1 ATP synthase B/B' CF(0) ATP-synt_C PF00137.21 CDW59604.1 - 9.8e-12 45.0 8.6 9.8e-12 45.0 8.6 1.6 2 0 0 2 2 2 1 ATP synthase subunit C Mt_ATP-synt_B PF05405.14 CDW59604.1 - 0.00067 19.3 7.1 0.0027 17.3 7.1 1.8 1 1 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF3552 PF12072.8 CDW59604.1 - 0.0014 18.1 10.4 0.0014 18.1 10.4 2.8 1 1 2 3 3 3 1 Domain of unknown function (DUF3552) Abhydrolase_9_N PF15420.6 CDW59604.1 - 0.0016 18.5 1.4 0.0094 16.0 1.6 1.8 1 1 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus DLP_helical PF18709.1 CDW59604.1 - 0.029 13.6 9.7 0.044 13.0 9.7 1.2 1 0 0 1 1 1 0 Dynamin-like helical domain ABC2_membrane_3 PF12698.7 CDW59604.1 - 0.09 11.9 0.3 0.13 11.3 0.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein FAM25 PF15825.5 CDW59604.1 - 0.83 10.0 4.1 0.49 10.8 0.5 2.4 2 1 0 2 2 2 0 FAM25 family ATP-synt_ab PF00006.25 CDW59605.1 - 1.3e-70 237.4 0.0 1.8e-70 236.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CDW59605.1 - 1.1e-48 164.7 0.2 2e-48 163.9 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CDW59605.1 - 1.1e-20 73.9 0.6 2.8e-20 72.6 0.6 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CDW59605.1 - 0.00025 20.5 0.3 0.00071 19.0 0.3 1.8 1 0 0 1 1 1 1 KaiC Arginosuc_synth PF00764.19 CDW59605.1 - 0.11 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase ATP-synt PF00231.19 CDW59606.1 - 1.6e-70 238.0 0.1 1.8e-70 237.9 0.1 1.0 1 0 0 1 1 1 1 ATP synthase ATP-synt_ab PF00006.25 CDW59607.1 - 3e-67 226.4 0.0 4.5e-67 225.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CDW59607.1 - 3.7e-23 81.8 2.1 8.4e-23 80.7 2.1 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RsgA_GTPase PF03193.16 CDW59607.1 - 3.7e-05 23.7 0.1 8.2e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 CDW59607.1 - 0.0075 16.8 0.1 0.024 15.2 0.0 1.9 2 0 0 2 2 2 1 ABC transporter NACHT PF05729.12 CDW59607.1 - 0.0088 16.0 0.3 0.029 14.3 0.0 1.9 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 CDW59607.1 - 0.0089 16.0 0.0 0.028 14.3 0.0 1.8 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 CDW59607.1 - 0.011 16.1 0.2 0.1 13.1 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T3SS_ATPase_C PF18269.1 CDW59607.1 - 0.013 15.3 0.9 0.035 14.0 0.9 1.7 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_16 PF13191.6 CDW59607.1 - 0.014 15.8 1.4 0.16 12.4 1.4 2.6 1 1 0 1 1 1 0 AAA ATPase domain ATPase PF06745.13 CDW59607.1 - 0.016 14.5 0.9 0.016 14.5 0.9 2.4 3 0 0 3 3 3 0 KaiC AAA_25 PF13481.6 CDW59607.1 - 0.025 14.2 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDW59607.1 - 0.067 13.5 1.2 0.075 13.4 0.4 1.7 2 1 0 2 2 1 0 AAA domain AAA_7 PF12775.7 CDW59607.1 - 0.075 12.5 0.2 0.29 10.6 0.1 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CDW59607.1 - 0.094 13.1 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase NB-ARC PF00931.22 CDW59607.1 - 0.096 11.9 0.9 0.15 11.2 0.4 1.5 2 0 0 2 2 2 0 NB-ARC domain MobB PF03205.14 CDW59607.1 - 0.16 11.9 0.2 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TrwB_AAD_bind PF10412.9 CDW59607.1 - 0.23 10.3 0.2 0.46 9.3 0.2 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF2922 PF11148.8 CDW59608.1 - 0.01 15.6 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2922) EGF PF00008.27 CDW59609.1 - 2.7e-13 50.0 42.7 5.9e-05 23.3 8.7 5.0 4 2 0 4 4 4 4 EGF-like domain EGF_2 PF07974.13 CDW59609.1 - 2.6e-10 40.5 54.3 0.0003 21.1 12.6 4.5 4 0 0 4 4 4 4 EGF-like domain hEGF PF12661.7 CDW59609.1 - 1.1e-07 32.2 43.3 0.0013 19.3 6.1 5.7 5 2 0 5 5 5 3 Human growth factor-like EGF EGF_CA PF07645.15 CDW59609.1 - 3.4e-06 27.2 11.9 3.4e-06 27.2 11.9 4.7 2 1 2 4 4 4 2 Calcium-binding EGF domain EGF_3 PF12947.7 CDW59609.1 - 0.00016 21.8 9.6 0.00016 21.8 9.6 5.3 3 1 1 4 4 4 1 EGF domain FXa_inhibition PF14670.6 CDW59609.1 - 0.0054 17.0 42.5 0.25 11.7 7.1 4.6 1 1 3 4 4 4 3 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW59609.1 - 0.0068 16.3 37.0 0.15 12.0 7.5 4.8 4 1 0 4 4 4 3 Complement Clr-like EGF-like Laminin_EGF PF00053.24 CDW59609.1 - 0.046 13.9 44.0 0.65 10.2 4.5 4.5 1 1 3 4 4 4 0 Laminin EGF domain Laminin_EGF PF00053.24 CDW59610.1 - 0.0033 17.5 0.9 0.0061 16.7 0.9 1.4 1 0 0 1 1 1 1 Laminin EGF domain EGF_2 PF07974.13 CDW59610.1 - 0.022 15.1 1.8 0.048 14.0 1.8 1.5 1 0 0 1 1 1 0 EGF-like domain ABC1 PF03109.16 CDW59611.1 - 1.2e-32 112.6 0.0 2.1e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 CDW59611.1 - 0.057 12.8 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain G-patch PF01585.23 CDW59612.1 - 2.3e-05 24.2 0.1 4.8e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 G-patch domain Rer1 PF03248.13 CDW59613.1 - 2.3e-74 248.8 8.4 7.6e-74 247.1 8.4 1.7 1 1 0 1 1 1 1 Rer1 family Bestrophin PF01062.21 CDW59613.1 - 0.1 12.0 4.1 0.18 11.2 4.1 1.3 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel IclR PF01614.18 CDW59614.1 - 7.7e-42 142.2 0.0 1.5e-41 141.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial transcriptional regulator HTH_IclR PF09339.10 CDW59614.1 - 4.5e-19 68.0 0.5 1.2e-18 66.6 0.3 1.9 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR_2 PF12802.7 CDW59614.1 - 0.00013 21.8 0.0 0.00028 20.7 0.0 1.5 1 0 0 1 1 1 1 MarR family MarR PF01047.22 CDW59614.1 - 0.001 18.9 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 CDW59614.1 - 0.0011 18.5 0.0 0.0022 17.5 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 CDW59614.1 - 0.0017 18.6 0.0 0.0064 16.8 0.0 1.9 1 0 0 1 1 1 1 Transcriptional regulator HTH_20 PF12840.7 CDW59614.1 - 0.0097 16.0 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 CDW59614.1 - 0.032 14.2 0.1 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain TrmB PF01978.19 CDW59614.1 - 0.09 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Met_synt_B12 PF02965.17 CDW59615.1 - 1.4e-129 431.4 0.0 2.3e-129 430.7 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 CDW59615.1 - 5e-80 269.2 0.1 9.2e-80 268.3 0.1 1.5 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 CDW59615.1 - 2e-63 214.3 0.5 2.3e-62 210.8 0.3 2.7 3 0 0 3 3 3 1 Pterin binding enzyme B12-binding_2 PF02607.17 CDW59615.1 - 1.5e-25 89.4 0.7 4.1e-25 88.0 0.1 2.2 2 0 0 2 2 2 1 B12 binding domain B12-binding PF02310.19 CDW59615.1 - 8.3e-19 67.8 0.2 3.9e-18 65.6 0.2 2.2 1 0 0 1 1 1 1 B12 binding domain Na_Pi_cotrans PF02690.15 CDW59616.1 - 1.8e-24 86.4 23.2 2.9e-17 63.1 4.1 2.4 1 1 1 2 2 2 2 Na+/Pi-cotransporter PhoU PF01895.19 CDW59616.1 - 0.001 19.5 4.8 0.11 13.0 2.2 3.2 2 1 1 3 3 3 2 PhoU domain Peptidase_S51 PF03575.17 CDW59617.1 - 3e-59 200.2 0.0 3.3e-59 200.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S51 BPL_N PF09825.9 CDW59617.1 - 0.013 14.6 0.0 0.018 14.1 0.0 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal PseudoU_synth_2 PF00849.22 CDW59618.1 - 8.4e-16 58.5 0.0 3.7e-15 56.4 0.0 1.9 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDW59618.1 - 3.6e-14 52.2 2.8 5.5e-14 51.6 0.0 2.8 3 1 1 4 4 4 1 S4 domain S4_2 PF13275.6 CDW59618.1 - 0.00061 19.6 0.0 0.0016 18.2 0.0 1.7 1 0 0 1 1 1 1 S4 domain AA_kinase PF00696.28 CDW59619.1 - 2.2e-47 161.7 0.2 3.3e-47 161.1 0.2 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 CDW59619.1 - 1.9e-08 33.9 0.0 2.4e-06 27.2 0.0 2.7 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 CDW59619.1 - 1.1e-06 28.4 0.1 0.042 13.7 0.0 3.1 3 0 0 3 3 3 2 ACT domain PGI PF00342.19 CDW59620.1 - 8.5e-259 859.0 0.1 9.7e-259 858.8 0.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase YjbH PF06082.11 CDW59621.1 - 2.1e-270 899.2 12.7 2.4e-270 899.0 12.7 1.0 1 0 0 1 1 1 1 Exopolysaccharide biosynthesis protein YbjH YL1_C PF08265.11 CDW59621.1 - 0.11 12.3 0.1 23 4.8 0.1 3.1 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain PID PF00640.23 CDW59622.1 - 2.3e-22 79.5 0.2 3.8e-22 78.8 0.2 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 CDW59622.1 - 2.5e-09 37.4 0.0 4e-08 33.5 0.0 2.4 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 CDW59622.1 - 0.019 14.8 0.0 0.052 13.4 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Ham1p_like PF01725.16 CDW59623.1 - 9.4e-48 162.6 0.0 1.1e-47 162.4 0.0 1.0 1 0 0 1 1 1 1 Ham1 family G-gamma PF00631.22 CDW59624.1 - 4.3e-13 49.1 0.0 4.9e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 GGL domain Syntaxin_2 PF14523.6 CDW59624.1 - 0.011 16.1 0.2 0.013 15.8 0.2 1.0 1 0 0 1 1 1 0 Syntaxin-like protein ADIP PF11559.8 CDW59624.1 - 0.033 14.3 0.4 0.038 14.1 0.4 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CP12 PF02672.15 CDW59624.1 - 0.033 14.9 0.1 0.045 14.5 0.1 1.2 1 0 0 1 1 1 0 CP12 domain COPI_C PF06957.11 CDW59624.1 - 0.046 12.5 0.1 0.051 12.3 0.1 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus EGF PF00008.27 CDW59625.1 - 3.4e-34 116.7 124.7 2.3e-05 24.6 9.4 9.8 9 0 0 9 9 9 9 EGF-like domain EGF_CA PF07645.15 CDW59625.1 - 2.6e-29 101.1 138.7 8.5e-09 35.5 9.7 9.3 5 2 4 9 9 9 6 Calcium-binding EGF domain EGF_2 PF07974.13 CDW59625.1 - 4e-20 71.9 151.8 0.0013 19.0 11.4 9.6 9 0 0 9 9 9 9 EGF-like domain hEGF PF12661.7 CDW59625.1 - 9.7e-17 60.9 119.7 0.0022 18.5 7.7 10.6 10 0 0 10 10 10 7 Human growth factor-like EGF EGF_3 PF12947.7 CDW59625.1 - 1e-06 28.8 122.5 0.0033 17.6 8.8 9.8 8 1 1 9 9 9 5 EGF domain FXa_inhibition PF14670.6 CDW59625.1 - 0.00016 21.9 105.7 0.026 14.8 9.1 9.8 4 4 5 9 9 9 5 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW59625.1 - 0.0062 16.4 1.6 0.0062 16.4 1.6 9.2 10 0 0 10 10 10 5 Complement Clr-like EGF-like Laminin_EGF PF00053.24 CDW59625.1 - 0.48 10.6 118.9 0.59 10.3 8.3 9.4 2 2 7 9 9 9 0 Laminin EGF domain EGF PF00008.27 CDW59626.1 - 7.2e-22 77.3 77.5 1.2e-06 28.7 6.3 7.3 7 2 0 7 7 7 6 EGF-like domain hEGF PF12661.7 CDW59626.1 - 2.6e-10 40.5 65.7 2.8e-05 24.6 4.1 8.4 7 2 1 8 8 8 4 Human growth factor-like EGF EGF_CA PF07645.15 CDW59626.1 - 1.5e-08 34.7 8.7 1.5e-08 34.7 8.7 7.0 3 1 3 6 6 6 2 Calcium-binding EGF domain EGF_2 PF07974.13 CDW59626.1 - 1.3e-05 25.5 84.2 0.014 15.8 10.3 6.7 6 0 0 6 6 6 5 EGF-like domain EGF_3 PF12947.7 CDW59626.1 - 0.00015 21.9 58.1 0.005 17.0 5.5 7.0 5 2 1 6 6 6 4 EGF domain FXa_inhibition PF14670.6 CDW59626.1 - 0.048 13.9 4.7 0.048 13.9 4.7 6.7 4 2 2 6 6 6 0 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 CDW59626.1 - 0.22 11.7 60.1 2 8.6 2.1 6.7 4 1 2 6 6 6 0 Laminin EGF domain LIM PF00412.22 CDW59627.1 - 9.8e-11 41.7 37.8 1.4e-08 34.8 14.6 2.7 2 1 0 2 2 2 2 LIM domain Homeodomain PF00046.29 CDW59627.1 - 5.8e-09 35.7 0.0 1.3e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Homeodomain DUF2981 PF11200.8 CDW59627.1 - 0.25 11.1 0.9 0.34 10.6 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) WD40 PF00400.32 CDW59629.1 - 8.7e-22 77.0 9.3 1.9e-06 28.5 0.5 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat UTP15_C PF09384.10 CDW59629.1 - 6.7e-17 61.5 0.0 3.4e-14 52.8 0.0 2.3 2 0 0 2 2 2 2 UTP15 C terminal ANAPC4_WD40 PF12894.7 CDW59629.1 - 4.7e-08 33.2 0.0 1.1 9.6 0.0 5.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CDW59629.1 - 0.0002 20.8 0.0 0.0007 19.0 0.0 1.8 1 1 0 1 1 1 1 WD40-like domain Coatomer_WDAD PF04053.14 CDW59629.1 - 0.022 13.8 0.0 0.043 12.9 0.0 1.4 1 0 0 1 1 1 0 Coatomer WD associated region Tetraspanin PF00335.20 CDW59630.1 - 1.1e-41 143.0 2.6 1.4e-41 142.7 2.6 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2207 PF09972.9 CDW59630.1 - 4.1 6.1 7.9 0.15 10.8 1.5 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Histone PF00125.24 CDW59631.1 - 5.6e-17 62.3 0.7 5.6e-17 62.3 0.7 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 DUF743 PF05332.11 CDW59631.1 - 0.0046 17.0 0.1 0.0051 16.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF743) CENP-T_C PF15511.6 CDW59631.1 - 0.0069 16.5 0.1 0.011 15.8 0.1 1.4 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 CDW59631.1 - 0.029 14.5 0.7 0.12 12.5 0.2 1.8 1 1 1 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 CDW59632.1 - 5.4e-17 62.4 0.8 5.4e-17 62.4 0.8 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 DUF743 PF05332.11 CDW59632.1 - 0.00089 19.3 0.1 0.00097 19.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF743) CENP-T_C PF15511.6 CDW59632.1 - 0.0074 16.4 0.1 0.012 15.8 0.1 1.5 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 CDW59632.1 - 0.03 14.4 0.9 0.12 12.5 0.2 1.8 1 1 1 2 2 2 0 Transcription initiation factor IID, 31kD subunit APG9 PF04109.16 CDW59633.1 - 3.7e-115 385.7 17.5 4.6e-115 385.4 17.5 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 Nrap_D5 PF17406.2 CDW59634.1 - 2.5e-37 128.2 0.1 5.3e-35 120.6 0.0 2.5 2 0 0 2 2 2 2 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 CDW59634.1 - 3e-23 82.6 0.0 5.8e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D2 PF17403.2 CDW59634.1 - 9.2e-23 80.7 0.1 2.8e-21 75.9 0.0 3.1 3 0 0 3 3 3 1 Nrap protein PAP/OAS-like domain Nrap PF03813.14 CDW59634.1 - 5.8e-19 68.6 1.0 1.4e-18 67.4 0.1 2.1 2 0 0 2 2 2 1 Nrap protein domain 1 Nrap_D6 PF17407.2 CDW59634.1 - 4.2e-12 46.4 0.0 1.3e-11 44.8 0.0 1.9 1 0 0 1 1 1 1 Nrap protein domain 6 Nrap_D4 PF17405.2 CDW59634.1 - 6.1e-11 42.1 0.0 1.2e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 DUF2177 PF09945.9 CDW59635.1 - 0.17 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2177) DUF465 PF04325.13 CDW59635.1 - 3.2 7.9 6.6 7 6.8 3.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF465) His_Phos_1 PF00300.22 CDW59636.1 - 1.6e-12 47.6 0.0 3.1e-12 46.6 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Sulfotransfer_1 PF00685.27 CDW59637.1 - 0.012 15.1 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CDW59637.1 - 0.013 15.9 0.0 0.017 15.5 0.0 1.2 1 0 0 1 1 1 0 Sulfotransferase family CPSase_sm_chain PF00988.22 CDW59637.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain UBN_AB PF14075.6 CDW59638.1 - 0.032 14.0 0.0 0.034 13.9 0.0 1.0 1 0 0 1 1 1 0 Ubinuclein conserved middle domain UCH PF00443.29 CDW59639.1 - 3.3e-42 144.7 0.5 4.6e-42 144.3 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CDW59639.1 - 0.021 14.4 9.9 0.15 11.6 5.0 2.6 1 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase PGK PF00162.19 CDW59639.1 - 0.092 11.7 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Phosphoglycerate kinase Peptidase_C13 PF01650.18 CDW59640.1 - 0.00033 20.3 0.1 0.0005 19.7 0.1 1.2 1 0 0 1 1 1 1 Peptidase C13 family zf-BED PF02892.15 CDW59640.1 - 0.0021 18.0 0.0 0.0046 16.9 0.0 1.6 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_12 PF18658.1 CDW59640.1 - 0.0088 15.6 0.2 0.042 13.4 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger C2H2-type ACBP PF00887.19 CDW59642.1 - 2.8e-12 46.7 0.1 3.1e-12 46.5 0.1 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 CDW59642.1 - 0.052 14.0 0.1 0.065 13.6 0.1 1.3 1 1 0 1 1 1 0 FERM central domain EXS PF03124.14 CDW59643.1 - 5e-95 318.6 22.6 8.9e-95 317.8 22.6 1.4 1 0 0 1 1 1 1 EXS family SPX PF03105.19 CDW59643.1 - 4.3e-34 119.1 13.6 1e-15 58.6 0.3 3.2 1 1 2 3 3 3 3 SPX domain DUF4665 PF15679.5 CDW59643.1 - 0.16 12.6 0.0 0.34 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4665) Med19 PF10278.9 CDW59644.1 - 2.4e-33 115.6 23.1 1.3e-31 109.9 23.1 2.0 1 1 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 Eapp_C PF10238.9 CDW59644.1 - 0.029 14.5 0.8 0.043 13.9 0.8 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF4604 PF15377.6 CDW59644.1 - 0.43 11.0 12.7 0.63 10.4 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MCRS_N PF13325.6 CDW59645.1 - 2.1e-27 96.5 0.0 2.9e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein DUF3809 PF12723.7 CDW59645.1 - 0.075 13.3 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3809) NAC PF01849.18 CDW59646.1 - 1.3e-20 73.1 0.3 2.4e-19 69.0 0.2 2.3 2 0 0 2 2 2 1 NAC domain UBA_4 PF14555.6 CDW59646.1 - 0.078 12.8 0.0 0.3 10.9 0.0 2.1 1 0 0 1 1 1 0 UBA-like domain DUF4637 PF15470.6 CDW59646.1 - 3.6 7.3 12.1 0.55 10.0 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Peptidase_S64 PF08192.11 CDW59646.1 - 9.8 4.5 12.9 12 4.2 12.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 Spt4 PF06093.13 CDW59647.1 - 4.1e-31 106.9 0.1 5.1e-31 106.6 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger SBP PF03110.14 CDW59647.1 - 0.019 15.3 0.1 0.026 14.8 0.1 1.2 1 0 0 1 1 1 0 SBP domain Phospho_p8 PF10195.9 CDW59648.1 - 2.6e-15 56.7 1.7 4.3e-15 56.0 1.7 1.4 1 0 0 1 1 1 1 DNA-binding nuclear phosphoprotein p8 Zn_ribbon_17 PF17120.5 CDW59649.1 - 9.6e-06 25.1 19.8 9.6e-06 25.1 19.8 3.7 2 1 1 3 3 3 2 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 CDW59649.1 - 0.0099 16.1 5.8 0.0099 16.1 5.8 3.2 2 1 1 3 3 3 1 Zinc-ribbon like family zf-C2H2_4 PF13894.6 CDW59650.1 - 3.9e-05 24.1 11.4 0.01 16.6 2.2 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW59650.1 - 0.00016 22.0 12.7 0.058 13.9 1.8 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.7 CDW59650.1 - 0.0022 18.3 4.5 0.019 15.4 1.3 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type DUF5570 PF17731.1 CDW59650.1 - 0.011 15.9 1.0 0.4 10.8 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5570) zf-C2H2_jaz PF12171.8 CDW59650.1 - 0.032 14.5 1.6 0.032 14.5 1.6 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 CDW59650.1 - 0.12 12.6 2.6 0.34 11.2 2.6 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 CDW59650.1 - 0.2 12.1 0.2 0.2 12.1 0.2 4.0 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 CDW59650.1 - 0.24 11.5 8.4 2.4 8.3 2.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-UBP PF02148.19 CDW59650.1 - 1.3 9.4 5.9 5.4 7.4 3.9 2.7 2 1 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF4596 PF15363.6 CDW59650.1 - 1.8 8.9 5.4 0.59 10.4 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) zf-met PF12874.7 CDW59651.1 - 0.0087 16.4 3.6 0.022 15.1 3.6 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CDW59651.1 - 0.013 16.3 3.5 0.042 14.7 3.5 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_9 PF16293.5 CDW59651.1 - 0.035 13.9 0.1 0.12 12.2 0.1 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2 PF00096.26 CDW59651.1 - 0.13 12.7 3.5 0.32 11.5 3.5 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW59651.1 - 1.9 9.1 4.2 1.8 9.1 1.0 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.6 CDW59651.1 - 6.8 6.8 10.5 1.4 9.0 4.9 2.5 3 0 0 3 3 3 0 C2H2-type zinc finger NAD_kinase PF01513.21 CDW59652.1 - 2.6e-06 26.9 0.0 3.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 CDW59652.1 - 0.063 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain HLH PF00010.26 CDW59653.1 - 7.2e-17 61.1 3.1 1e-16 60.6 3.1 1.2 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain LIM PF00412.22 CDW59654.1 - 2.4e-10 40.5 8.3 2.4e-10 40.5 8.3 1.8 2 0 0 2 2 2 1 LIM domain DUF3348 PF11828.8 CDW59654.1 - 0.026 14.2 1.5 0.048 13.3 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) Val_tRNA-synt_C PF10458.9 CDW59654.1 - 8.5 6.8 10.0 2.6 8.4 1.0 2.9 2 1 1 3 3 3 0 Valyl tRNA synthetase tRNA binding arm DUF2095 PF09868.9 CDW59655.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) Cnd1 PF12717.7 CDW59655.1 - 0.028 14.5 0.8 0.069 13.2 0.1 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CDW59655.1 - 0.043 14.1 0.6 11 6.6 0.2 3.1 2 0 0 2 2 2 0 HEAT repeat Adaptin_N PF01602.20 CDW59655.1 - 0.056 12.0 0.0 0.096 11.2 0.0 1.3 1 0 0 1 1 1 0 Adaptin N terminal region CTNNBL PF08216.11 CDW59655.1 - 0.16 12.2 0.0 0.44 10.7 0.0 1.8 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear Zona_pellucida PF00100.23 CDW59656.1 - 1.3e-19 71.0 0.2 1.8e-19 70.6 0.2 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Afaf PF15339.6 CDW59656.1 - 0.008 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Acrosome formation-associated factor Zona_pellucida PF00100.23 CDW59658.1 - 5.4e-05 23.1 0.4 6.4e-05 22.9 0.4 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Histone PF00125.24 CDW59659.1 - 1.7e-20 73.7 0.1 2.1e-20 73.4 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59659.1 - 1.1e-05 25.6 0.0 2.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW59659.1 - 0.007 16.4 0.2 0.0079 16.2 0.2 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 CDW59659.1 - 0.012 16.1 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone_H2A_C PF16211.5 CDW59660.1 - 3.2e-19 68.4 0.2 6.5e-19 67.4 0.2 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW59660.1 - 4.7e-16 59.3 0.0 6e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59660.1 - 8e-05 22.9 0.0 0.00011 22.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GTP_EFTU_D3 PF03143.17 CDW59661.1 - 3.3e-31 107.9 0.0 6.4e-31 107.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDW59661.1 - 1.6e-18 66.9 6.7 2.5e-18 66.2 6.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Ribosomal_L11_N PF03946.14 CDW59662.1 - 4.2e-27 93.8 0.1 1e-26 92.6 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CDW59662.1 - 4.6e-25 87.9 2.3 9.2e-25 86.9 2.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain NusG PF02357.19 CDW59662.1 - 1.1e-21 77.2 0.0 2.1e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 Transcription termination factor nusG SecE PF00584.20 CDW59662.1 - 1.3e-17 63.4 0.5 1.3e-17 63.4 0.5 2.6 3 0 0 3 3 3 1 SecE/Sec61-gamma subunits of protein translocation complex KOW PF00467.29 CDW59662.1 - 1.4e-08 34.4 0.3 1.9e-07 30.8 0.1 2.7 3 0 0 3 3 3 1 KOW motif DUF555 PF04475.12 CDW59662.1 - 0.12 12.7 0.1 5.4 7.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF555) Ribosomal_L1 PF00687.21 CDW59663.1 - 1.6e-52 178.3 0.2 2e-52 177.9 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Ribosomal_L10 PF00466.20 CDW59664.1 - 3.9e-26 91.1 0.0 5.6e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF349 PF03993.12 CDW59664.1 - 0.3 11.4 2.7 0.44 10.9 0.0 2.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) RNA_pol_Rpb2_6 PF00562.28 CDW59665.1 - 1.1e-160 535.0 0.1 1e-159 531.8 0.3 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb1_1 PF04997.12 CDW59665.1 - 1.3e-89 300.6 0.0 2.3e-89 299.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CDW59665.1 - 1.1e-77 261.1 0.0 2.3e-77 260.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb2_1 PF04563.15 CDW59665.1 - 4.5e-58 196.1 0.1 9.8e-58 195.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb1_2 PF00623.20 CDW59665.1 - 7e-37 127.2 0.0 9.5e-27 94.2 0.0 2.8 1 1 1 2 2 2 2 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb2_3 PF04565.16 CDW59665.1 - 7.7e-31 106.1 0.0 2.2e-30 104.7 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 Ribosomal_L12 PF00542.19 CDW59665.1 - 1.4e-28 99.0 6.6 1.4e-28 99.0 6.6 3.5 4 0 0 4 4 4 1 Ribosomal protein L7/L12 C-terminal domain RNA_pol_Rpb2_45 PF10385.9 CDW59665.1 - 1.6e-27 95.5 0.3 1.6e-27 95.5 0.3 3.5 4 0 0 4 4 4 1 RNA polymerase beta subunit external 1 domain RNA_pol_Rpb2_7 PF04560.20 CDW59665.1 - 1.7e-27 95.7 0.0 5.4e-27 94.0 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb1_3 PF04983.18 CDW59665.1 - 3e-27 95.5 0.0 1.2e-26 93.5 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb2_2 PF04561.14 CDW59665.1 - 6.9e-23 81.3 6.9 1.4e-14 54.1 0.1 3.5 4 0 0 4 4 4 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb1_4 PF05000.17 CDW59665.1 - 1.2e-18 67.1 0.3 3.3e-18 65.6 0.3 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Ribosomal_L12_N PF16320.5 CDW59665.1 - 1.3e-10 40.8 8.9 5.6e-10 38.8 8.9 2.2 1 0 0 1 1 1 1 Ribosomal protein L7/L12 dimerisation domain Peptidase_M23 PF01551.22 CDW59665.1 - 0.025 14.8 0.0 3.8 7.8 0.0 4.3 4 0 0 4 4 4 0 Peptidase family M23 SPG4 PF17325.2 CDW59665.1 - 0.12 13.5 0.0 0.39 11.8 0.0 1.8 1 0 0 1 1 1 0 Stationary phase protein 4 ThiC_Rad_SAM PF01964.18 CDW59666.1 - 2.7e-159 530.5 0.1 1.3e-158 528.2 0.0 2.1 3 0 0 3 3 3 1 Radical SAM ThiC family ThiG PF05690.14 CDW59666.1 - 4.3e-101 337.4 1.6 8.1e-101 336.5 1.6 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG ThiF PF00899.21 CDW59666.1 - 1e-64 218.3 0.0 1.7e-64 217.5 0.0 1.3 1 0 0 1 1 1 1 ThiF family TMP-TENI PF02581.17 CDW59666.1 - 7.4e-50 168.8 1.5 2.1e-47 160.8 0.0 3.4 3 0 0 3 3 3 1 Thiamine monophosphate synthase BATS PF06968.13 CDW59666.1 - 2e-20 72.7 0.0 5.3e-20 71.3 0.0 1.8 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CDW59666.1 - 2.2e-09 37.9 0.0 4.3e-08 33.7 0.0 2.9 3 0 0 3 3 3 1 Radical SAM superfamily His_biosynth PF00977.21 CDW59666.1 - 1.4e-05 24.7 0.1 5.8e-05 22.7 0.1 2.0 2 0 0 2 2 2 1 Histidine biosynthesis protein ThiS PF02597.20 CDW59666.1 - 9.3e-05 23.0 0.0 0.00032 21.3 0.0 1.9 1 0 0 1 1 1 1 ThiS family Sacchrp_dh_NADP PF03435.18 CDW59666.1 - 0.0011 19.3 0.0 0.0047 17.2 0.0 2.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CDW59666.1 - 0.0034 17.8 0.0 0.0088 16.5 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding FMN_dh PF01070.18 CDW59666.1 - 0.048 12.7 0.5 0.11 11.5 0.5 1.5 1 0 0 1 1 1 0 FMN-dependent dehydrogenase IMPDH PF00478.25 CDW59666.1 - 0.049 12.6 2.0 0.049 12.6 0.6 1.6 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain NanE PF04131.14 CDW59666.1 - 0.066 12.4 0.2 0.15 11.2 0.2 1.5 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Syja_N PF02383.18 CDW59667.1 - 4.4e-69 233.2 0.1 2e-68 231.1 0.0 1.9 2 0 0 2 2 2 1 SacI homology domain UL41A PF17591.2 CDW59667.1 - 0.12 12.5 0.1 0.31 11.1 0.1 1.7 1 0 0 1 1 1 0 Herpesvirus UL41A Ras PF00071.22 CDW59669.1 - 5.8e-52 175.6 0.0 6.8e-52 175.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW59669.1 - 1.2e-28 99.7 0.0 1.7e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW59669.1 - 2.4e-08 33.6 0.0 3.5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW59669.1 - 0.0023 17.5 0.0 0.0046 16.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CDW59669.1 - 0.0031 17.0 0.0 0.63 9.6 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B MMR_HSR1 PF01926.23 CDW59669.1 - 0.0055 16.8 0.0 0.009 16.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW59669.1 - 0.035 14.0 0.2 7 6.5 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 CDW59669.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 CDW59669.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain MATH PF00917.26 CDW59670.1 - 3.4e-10 40.1 0.1 5.8e-10 39.3 0.1 1.4 1 0 0 1 1 1 1 MATH domain zf-RING_2 PF13639.6 CDW59672.1 - 0.0043 17.4 6.7 0.011 16.0 6.7 1.8 1 0 0 1 1 1 1 Ring finger domain V-SNARE_C PF12352.8 CDW59672.1 - 0.009 16.3 0.4 0.02 15.2 0.0 1.7 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus zf-RING_5 PF14634.6 CDW59672.1 - 0.028 14.4 5.2 0.028 14.4 5.2 1.8 2 0 0 2 2 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CDW59672.1 - 0.033 14.0 6.8 0.075 12.9 6.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CDW59672.1 - 0.057 13.2 1.8 0.16 11.7 1.8 1.8 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4 PF00097.25 CDW59672.1 - 0.073 13.0 5.7 0.24 11.3 5.7 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CASP_C PF08172.12 CDW59672.1 - 0.076 12.4 3.0 0.11 11.8 0.7 2.0 2 0 0 2 2 2 0 CASP C terminal Med9 PF07544.13 CDW59672.1 - 0.21 11.7 4.6 0.41 10.8 4.6 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4682 PF15733.5 CDW59672.1 - 0.32 11.6 7.8 2.3 8.8 0.7 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4682) Prok-RING_4 PF14447.6 CDW59672.1 - 0.94 9.4 8.0 2.7 7.9 7.9 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CDW59672.1 - 1.4 9.0 7.1 3.2 7.8 7.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DUF2540 PF10802.8 CDW59672.1 - 1.6 8.9 5.3 0.39 10.8 0.7 2.3 1 1 1 3 3 3 0 Protein of unknown function (DUF2540) DivIC PF04977.15 CDW59672.1 - 1.8 8.4 6.7 0.46 10.3 0.3 2.6 2 1 1 3 3 3 0 Septum formation initiator APG6_N PF17675.1 CDW59672.1 - 3.3 8.3 10.5 1.1 9.9 7.3 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region zf-C3H2C3 PF17122.5 CDW59672.1 - 3.3 7.8 6.6 7 6.8 6.6 1.6 1 0 0 1 1 1 0 Zinc-finger HIP1_clath_bdg PF16515.5 CDW59672.1 - 5.5 7.7 10.7 3.1 8.5 5.2 2.7 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Peptidase_M18 PF02127.15 CDW59674.1 - 5.8e-75 252.7 0.0 9.6e-75 252.0 0.0 1.3 2 0 0 2 2 2 1 Aminopeptidase I zinc metalloprotease (M18) LTV PF04180.14 CDW59675.1 - 1.3e-42 146.9 11.5 1.4e-33 117.2 0.5 3.1 2 1 1 3 3 3 3 Low temperature viability protein Kunitz_BPTI PF00014.23 CDW59677.1 - 1e-27 96.1 13.6 2.9e-15 56.2 0.9 2.1 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain SAD_SRA PF02182.17 CDW59677.1 - 0.0017 18.1 0.3 0.93 9.2 0.0 2.1 1 1 1 2 2 2 2 SAD/SRA domain Glyco_hydro_20 PF00728.22 CDW59677.1 - 0.11 11.9 0.1 0.17 11.2 0.0 1.4 1 1 1 2 2 2 0 Glycosyl hydrolase family 20, catalytic domain PAN_2 PF08276.11 CDW59677.1 - 0.65 10.2 5.0 5.1 7.3 1.0 2.5 2 0 0 2 2 2 0 PAN-like domain Pkinase PF00069.25 CDW59678.1 - 4.7e-61 206.5 0.0 5.4e-61 206.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59678.1 - 2.2e-27 96.0 0.0 3.3e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW59678.1 - 0.0007 19.0 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDW59678.1 - 0.0039 17.1 0.1 0.032 14.1 0.1 1.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family Sedlin_N PF04628.13 CDW59679.1 - 1.8e-37 128.4 0.1 2e-37 128.2 0.1 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 CDW59679.1 - 1e-07 32.0 0.0 2.9e-07 30.5 0.0 1.7 1 1 0 1 1 1 1 Sybindin-like family Proton_antipo_M PF00361.20 CDW59680.1 - 2.2e-05 23.8 2.3 3.1e-05 23.3 2.3 1.4 1 1 0 1 1 1 1 Proton-conducting membrane transporter Oxidored_q4 PF00507.19 CDW59681.1 - 2.5e-12 46.8 0.7 2.5e-12 46.8 0.7 2.0 2 0 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 COX3 PF00510.18 CDW59681.1 - 2.4e-07 30.9 0.9 2.4e-07 30.9 0.9 1.8 2 1 0 2 2 2 1 Cytochrome c oxidase subunit III DUF5074 PF16819.5 CDW59682.1 - 0.08 13.0 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5074) Peptidase_M41 PF01434.18 CDW59683.1 - 1.3e-49 168.7 1.0 6.3e-42 143.6 0.0 2.3 1 1 1 2 2 2 2 Peptidase family M41 AAA PF00004.29 CDW59683.1 - 9.3e-42 142.6 0.0 2e-41 141.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW59683.1 - 2.9e-08 33.4 0.1 6.5e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 CDW59683.1 - 4e-07 29.9 0.0 1.6e-06 28.0 0.0 2.0 1 1 1 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDW59683.1 - 7.1e-06 26.5 1.0 0.0011 19.4 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CDW59683.1 - 1.5e-05 25.0 0.2 0.00012 22.1 0.2 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CDW59683.1 - 0.00011 22.5 0.2 0.094 13.0 0.0 2.8 2 1 1 3 3 3 1 AAA domain IstB_IS21 PF01695.17 CDW59683.1 - 0.00025 20.8 0.0 0.00062 19.6 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 CDW59683.1 - 0.00078 18.7 0.1 0.003 16.8 0.0 1.8 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 CDW59683.1 - 0.002 18.3 0.0 0.0094 16.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CDW59683.1 - 0.015 14.7 0.3 0.058 12.8 0.1 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CDW59683.1 - 0.034 13.9 0.0 0.2 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDW59683.1 - 0.042 13.9 0.0 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDW59683.1 - 0.043 13.8 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CDW59683.1 - 0.062 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDW59683.1 - 0.062 13.2 0.2 0.15 11.9 0.1 1.7 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.13 CDW59683.1 - 0.075 12.2 0.0 0.24 10.5 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AdoHcyase_NAD PF00670.21 CDW59683.1 - 0.098 12.7 0.1 0.56 10.3 0.0 2.1 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AAA_2 PF07724.14 CDW59683.1 - 0.098 12.8 0.0 0.33 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 CDW59683.1 - 0.1 12.8 0.5 0.33 11.2 0.1 2.1 2 1 1 3 3 3 0 AAA domain AAA_7 PF12775.7 CDW59683.1 - 0.15 11.6 0.0 0.59 9.6 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 CDW59683.1 - 0.16 12.5 0.1 0.44 11.1 0.1 1.7 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 CDW59683.1 - 0.16 11.7 0.0 1.4 8.6 0.0 2.2 1 1 1 2 2 2 0 Sigma-54 interaction domain PGI PF00342.19 CDW59684.1 - 1.7e-254 844.8 0.0 2e-254 844.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase Urease_beta PF00699.20 CDW59684.1 - 0.087 12.9 0.1 0.25 11.4 0.1 1.7 2 0 0 2 2 2 0 Urease beta subunit 3Beta_HSD PF01073.19 CDW59685.1 - 1.8e-40 138.7 0.0 2.4e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDW59685.1 - 2.8e-11 43.4 0.0 3.7e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CDW59685.1 - 1.7e-06 27.4 0.0 2.5e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CDW59685.1 - 0.0024 17.1 0.0 0.065 12.4 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 CDW59685.1 - 0.064 12.3 0.0 0.56 9.3 0.0 2.0 1 1 0 1 1 1 0 RmlD substrate binding domain Semialdhyde_dh PF01118.24 CDW59685.1 - 0.19 12.2 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain eIF3g PF12353.8 CDW59686.1 - 0.014 15.8 1.3 0.014 15.8 1.3 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G CUB PF00431.20 CDW59687.1 - 6.7e-11 42.5 0.5 2e-10 40.9 0.1 2.0 2 0 0 2 2 2 1 CUB domain Globin PF00042.22 CDW59688.1 - 0.0019 18.8 0.0 0.0035 17.9 0.0 1.4 1 0 0 1 1 1 1 Globin DUF1759 PF03564.15 CDW59688.1 - 0.25 11.3 2.4 1 9.3 1.0 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1759) PGM_PMM_I PF02878.16 CDW59689.1 - 1.6e-11 44.1 0.0 3.7e-11 42.9 0.0 1.6 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDW59689.1 - 4.1e-11 43.1 0.0 9.2e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DNA_pol_E_B PF04042.16 CDW59690.1 - 2.2e-42 144.8 0.0 2.8e-42 144.5 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 CDW59690.1 - 0.048 13.8 0.0 0.083 13.0 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain Ras PF00071.22 CDW59691.1 - 1.1e-26 93.3 0.0 3.9e-25 88.3 0.0 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CDW59691.1 - 1.1e-19 70.8 0.0 1.6e-17 63.8 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW59691.1 - 4.1e-06 26.4 0.0 9.1e-05 22.0 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CDW59691.1 - 0.00014 21.9 0.0 0.0002 21.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW59691.1 - 0.0024 17.3 0.0 0.0039 16.6 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CDW59691.1 - 0.0031 17.4 0.0 0.48 10.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CDW59691.1 - 0.0078 16.5 0.0 0.23 11.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CDW59691.1 - 0.18 11.2 0.0 0.31 10.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PseudoU_synth_1 PF01416.20 CDW59692.1 - 6.8e-22 78.0 0.0 6.2e-16 58.8 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase CAP PF00188.26 CDW59693.1 - 1e-08 36.1 1.5 1e-08 36.1 1.5 1.6 2 0 0 2 2 2 1 Cysteine-rich secretory protein family PPP4R2 PF09184.11 CDW59693.1 - 0.0013 18.4 15.3 0.0016 18.1 15.3 1.3 1 0 0 1 1 1 1 PPP4R2 SAPS PF04499.15 CDW59693.1 - 0.0094 14.8 4.7 0.0074 15.1 4.7 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein SLC12 PF03522.15 CDW59693.1 - 0.58 9.1 11.3 0.74 8.8 11.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 U1snRNP70_N PF12220.8 CDW59694.1 - 7.9e-19 68.1 2.2 7.9e-19 68.1 2.2 2.2 3 0 0 3 3 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 CDW59694.1 - 1e-16 60.5 0.0 1.7e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 CDW59694.1 - 0.074 13.3 0.2 6.6 6.9 0.0 2.7 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 CDW59694.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif Pkinase_Tyr PF07714.17 CDW59695.1 - 1.1e-50 172.4 0.0 1.7e-50 171.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW59695.1 - 2.6e-45 154.8 0.0 4.8e-45 154.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FTA2 PF13095.6 CDW59695.1 - 0.064 12.9 0.0 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RhoGAP PF00620.27 CDW59696.1 - 6e-11 42.4 0.1 1.1e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 RhoGAP domain FERM_C PF09380.10 CDW59697.1 - 2.7e-24 85.4 0.5 5.5e-24 84.4 0.1 1.7 2 0 0 2 2 2 1 FERM C-terminal PH-like domain FA PF08736.11 CDW59697.1 - 7.4e-12 45.1 5.5 1.7e-11 44.0 5.5 1.7 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_N PF09379.10 CDW59697.1 - 1.2e-10 41.1 0.2 3.1e-10 39.8 0.2 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 CDW59697.1 - 1.9e-06 28.3 0.0 3.5e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 FERM central domain DUF1115 PF06544.12 CDW59697.1 - 0.012 15.7 0.1 0.046 13.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1115) DUF525 PF04379.14 CDW59698.1 - 3.7e-27 94.4 0.0 6.3e-27 93.7 0.0 1.4 1 0 0 1 1 1 1 ApaG domain YccV-like PF08755.11 CDW59698.1 - 2.2e-10 40.9 0.1 8.2e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like MAGP PF05507.11 CDW59698.1 - 0.16 12.4 0.1 17 5.9 0.0 2.2 2 0 0 2 2 2 0 Microfibril-associated glycoprotein (MAGP) Peptidase_M18 PF02127.15 CDW59699.1 - 2.3e-72 244.2 0.1 2.7e-72 243.9 0.1 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CDW59699.1 - 1.1e-06 27.8 0.1 3e-06 26.5 0.0 1.6 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Phage_connector PF05352.12 CDW59700.1 - 1.5e-36 126.3 1.1 3.2e-36 125.2 1.1 1.5 1 0 0 1 1 1 1 Phage Connector (GP10) Phage_lysozyme2 PF18013.1 CDW59700.1 - 3.4e-22 79.0 0.0 7.4e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 Phage tail lysozyme Caud_tail_N PF16838.5 CDW59700.1 - 2.3e-19 69.9 6.6 2.3e-19 69.9 6.6 3.1 3 0 0 3 3 3 1 Caudoviral major tail protein N-terminus DUF3364 PF11844.8 CDW59701.1 - 0.049 13.9 0.1 0.093 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3364) Hema_esterase PF03996.15 CDW59703.1 - 0.0023 17.7 0.5 0.61 9.8 0.1 2.6 2 0 0 2 2 2 2 Hemagglutinin esterase Glycoprotein_G PF00802.19 CDW59703.1 - 0.0053 16.1 0.5 2.4 7.4 0.1 2.6 2 0 0 2 2 2 2 Pneumovirus attachment glycoprotein G OrsD PF12013.8 CDW59703.1 - 0.041 14.3 0.1 0.098 13.1 0.1 1.5 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-CCHC PF00098.23 CDW59704.1 - 5.9e-06 26.1 1.3 1e-05 25.3 1.3 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 CDW59704.1 - 0.002 17.8 0.9 0.0052 16.5 0.9 1.7 1 0 0 1 1 1 1 Zinc knuckle RVP_2 PF08284.11 CDW59704.1 - 0.053 13.3 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease gag-asp_proteas PF13975.6 CDW59704.1 - 0.12 12.9 0.1 0.24 12.0 0.1 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease HMG_box PF00505.19 CDW59705.1 - 3.5e-07 30.5 1.3 8.3e-07 29.3 1.3 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW59705.1 - 2.6e-05 24.7 0.7 5.3e-05 23.7 0.7 1.5 1 0 0 1 1 1 1 HMG-box domain Ribosom_S12_S23 PF00164.25 CDW59706.1 - 3.5e-52 174.8 0.7 4.5e-52 174.5 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Methyltransf_15 PF09445.10 CDW59706.1 - 0.014 15.0 0.0 0.016 14.8 0.0 1.1 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RCC1 PF00415.18 CDW59707.1 - 6.9e-25 87.4 2.5 5.4e-13 49.3 0.1 3.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CDW59707.1 - 1.5e-15 56.6 6.4 1.6e-08 34.1 0.2 3.4 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat TFIID-31kDa PF02291.15 CDW59708.1 - 3.1e-21 75.7 0.0 3.6e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 CDW59708.1 - 0.012 16.1 0.7 0.016 15.7 0.2 1.5 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A TFIID-18kDa PF02269.16 CDW59708.1 - 0.078 13.0 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit DDE_1 PF03184.19 CDW59709.1 - 0.0046 16.6 0.0 0.0066 16.1 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Peptidase_S9 PF00326.21 CDW59710.1 - 1.8e-40 138.7 0.0 2.4e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 CDW59710.1 - 1.4e-09 37.8 0.0 5e-09 36.0 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CDW59710.1 - 8.2e-07 28.5 0.0 0.017 14.4 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 BAAT_C PF08840.11 CDW59710.1 - 5.9e-05 23.1 0.0 0.0028 17.6 0.0 2.2 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 CDW59710.1 - 0.00012 22.8 0.2 0.0053 17.4 0.1 2.1 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CDW59710.1 - 0.0012 18.6 0.0 0.14 11.8 0.0 2.2 1 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CDW59710.1 - 0.012 15.2 0.0 1 8.9 0.0 2.3 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 CDW59710.1 - 0.017 15.0 0.3 0.13 12.1 0.1 2.4 2 1 0 2 2 2 0 alpha/beta hydrolase fold AXE1 PF05448.12 CDW59710.1 - 0.018 13.7 0.1 0.84 8.2 0.1 2.6 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF829 PF05705.14 CDW59710.1 - 0.059 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Abhydrolase_2 PF02230.16 CDW59710.1 - 0.077 12.8 0.0 0.27 11.0 0.0 1.8 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 CDW59710.1 - 0.11 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein RtcR PF06956.11 CDW59712.1 - 0.13 11.7 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 Regulator of RNA terminal phosphate cyclase WD40 PF00400.32 CDW59713.1 - 3.1e-43 144.9 18.4 1.1e-07 32.4 1.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW59713.1 - 1.6e-07 31.5 1.7 1.5 9.1 0.1 5.2 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CDW59713.1 - 5.3e-05 23.2 0.1 6 6.9 0.0 4.1 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 CDW59713.1 - 0.00031 19.6 0.2 0.7 8.6 0.1 3.8 1 1 2 3 3 3 2 Nup133 N terminal like WD40_like PF17005.5 CDW59713.1 - 0.0011 18.4 0.0 0.013 14.8 0.0 2.4 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 CDW59713.1 - 0.0011 17.7 3.5 0.32 9.6 1.1 3.4 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Read-through PF16814.5 CDW59713.1 - 0.014 15.2 0.1 0.36 10.6 0.0 2.8 2 1 1 3 3 3 0 Read-through domain TPR_2 PF07719.17 CDW59714.1 - 1.3e-21 74.8 16.4 0.00011 22.1 0.0 10.7 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_1 PF00515.28 CDW59714.1 - 3.1e-20 71.1 2.4 5.5e-05 22.8 0.0 8.7 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 CDW59714.1 - 1.5e-14 54.3 5.1 0.00041 20.8 0.0 7.1 5 1 3 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDW59714.1 - 1.6e-13 49.7 4.6 0.0096 16.1 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 CDW59714.1 - 2.2e-12 47.1 11.5 0.0002 21.6 0.1 7.9 6 1 2 8 8 8 3 Tetratricopeptide repeat Histone PF00125.24 CDW59714.1 - 4.1e-12 46.6 0.2 7.5e-12 45.7 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TPR_17 PF13431.6 CDW59714.1 - 1.2e-08 34.8 6.8 0.95 10.0 0.0 8.2 8 1 1 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW59714.1 - 1.2e-08 35.1 9.9 0.0009 19.4 0.1 5.5 4 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CDW59714.1 - 9.6e-08 31.6 0.1 0.036 13.7 0.0 5.2 4 1 1 5 5 5 2 TPR repeat TPR_14 PF13428.6 CDW59714.1 - 1.1e-07 32.1 17.1 1.1 10.3 0.0 8.7 5 2 5 10 10 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW59714.1 - 1.2e-06 29.1 7.8 0.69 10.6 0.0 6.6 5 3 2 7 7 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 CDW59714.1 - 5.2e-05 22.6 6.2 0.012 14.8 0.7 3.6 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CDW59714.1 - 0.00022 21.0 5.4 1 9.3 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW59714.1 - 0.00039 20.9 3.6 30 5.5 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDW59714.1 - 0.0014 18.5 5.3 6.9 6.9 0.0 5.4 5 1 0 5 5 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW59714.1 - 0.024 14.7 1.8 0.69 10.0 0.0 3.8 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat ABC_tran PF00005.27 CDW59715.1 - 5e-64 214.9 0.0 3.2e-32 111.9 0.0 2.9 2 0 0 2 2 2 2 ABC transporter PCRF PF03462.18 CDW59715.1 - 1.9e-48 164.9 1.4 7.4e-48 163.0 0.0 2.6 3 0 0 3 3 2 1 PCRF domain RF-1 PF00472.20 CDW59715.1 - 9.3e-42 141.6 0.3 2.6e-41 140.2 0.3 1.8 1 0 0 1 1 1 1 RF-1 domain PLDc_2 PF13091.6 CDW59715.1 - 7.2e-40 136.0 0.0 3.6e-21 75.4 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PBP_like_2 PF12849.7 CDW59715.1 - 5.6e-36 124.7 1.0 1.3e-35 123.4 1.0 1.6 1 0 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 CDW59715.1 - 1.4e-30 105.9 0.0 3e-30 104.8 0.0 1.6 1 0 0 1 1 1 1 PBP superfamily domain BPD_transp_1 PF00528.22 CDW59715.1 - 5.6e-24 84.9 16.5 5.6e-24 84.9 16.5 3.4 2 2 1 3 3 2 1 Binding-protein-dependent transport system inner membrane component FtsX_ECD PF18075.1 CDW59715.1 - 4.7e-19 68.8 0.8 1.6e-18 67.1 0.8 2.0 1 0 0 1 1 1 1 FtsX extracellular domain SMC_N PF02463.19 CDW59715.1 - 1.4e-13 50.8 0.3 4.9e-06 26.1 0.2 2.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDW59715.1 - 3.8e-12 46.7 0.1 0.056 13.2 0.0 4.3 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system PLDc PF00614.22 CDW59715.1 - 1.2e-11 44.2 6.2 4.7e-06 26.6 0.2 3.4 3 0 0 3 3 3 2 Phospholipase D Active site motif AAA_22 PF13401.6 CDW59715.1 - 1.4e-09 38.3 0.0 0.0013 19.0 0.0 3.5 3 1 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 CDW59715.1 - 1.8e-08 34.5 0.4 0.039 13.9 0.0 3.9 3 0 0 3 3 3 2 RsgA GTPase SBP_bac_11 PF13531.6 CDW59715.1 - 2.6e-08 33.9 0.0 1.7e-07 31.3 0.0 2.1 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein AAA_29 PF13555.6 CDW59715.1 - 6.8e-08 32.1 0.0 0.015 15.0 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 CDW59715.1 - 9.4e-08 32.2 0.2 0.00016 21.5 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_16 PF13191.6 CDW59715.1 - 3.4e-07 30.8 0.0 0.011 16.1 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain Rad17 PF03215.15 CDW59715.1 - 8.6e-07 29.1 0.0 0.00056 19.9 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_33 PF13671.6 CDW59715.1 - 3.8e-06 27.1 0.1 0.029 14.5 0.1 2.7 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CDW59715.1 - 1e-05 26.1 0.0 0.32 11.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CDW59715.1 - 8e-05 22.4 0.3 1.9 8.2 0.0 4.4 4 0 0 4 4 3 1 IstB-like ATP binding protein AAA_30 PF13604.6 CDW59715.1 - 0.00013 21.8 0.0 0.41 10.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CDW59715.1 - 0.00014 21.9 0.1 0.19 11.8 0.0 3.5 3 0 0 3 3 2 1 50S ribosome-binding GTPase Acetyltransf_10 PF13673.7 CDW59715.1 - 0.00014 21.8 0.0 0.00043 20.2 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ATPase_2 PF01637.18 CDW59715.1 - 0.00021 21.3 0.2 0.25 11.2 0.1 2.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CDW59715.1 - 0.00026 21.3 0.0 0.98 9.8 0.0 3.2 2 0 0 2 2 2 1 RNA helicase AAA PF00004.29 CDW59715.1 - 0.00038 20.9 0.0 2.6 8.5 0.0 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SBP_bac_1 PF01547.25 CDW59715.1 - 0.00056 20.0 0.3 0.0014 18.6 0.3 1.7 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein FtsX PF02687.21 CDW59715.1 - 0.0015 19.0 1.7 0.0015 19.0 1.7 5.3 4 1 0 5 5 4 1 FtsX-like permease family AAA_14 PF13173.6 CDW59715.1 - 0.0024 17.9 0.1 3.2 7.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Acetyltransf_1 PF00583.25 CDW59715.1 - 0.0028 17.9 0.0 0.013 15.7 0.1 2.1 2 0 0 2 2 1 1 Acetyltransferase (GNAT) family AAA_7 PF12775.7 CDW59715.1 - 0.0034 16.9 0.1 2.9 7.4 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 CDW59715.1 - 0.0039 16.9 0.0 2.4 7.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 CDW59715.1 - 0.0043 16.9 0.3 0.78 9.5 0.1 2.7 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 CDW59715.1 - 0.0045 16.2 0.1 2 7.5 0.0 2.7 3 0 0 3 3 3 1 G-protein alpha subunit AAA_23 PF13476.6 CDW59715.1 - 0.0097 16.4 0.0 0.0097 16.4 0.0 4.1 5 0 0 5 5 4 1 AAA domain AAA_28 PF13521.6 CDW59715.1 - 0.016 15.4 0.8 1.9 8.7 0.0 3.4 4 0 0 4 4 2 0 AAA domain Septin PF00735.18 CDW59715.1 - 0.017 14.5 0.0 0.83 8.9 0.0 2.4 2 0 0 2 2 2 0 Septin Acetyltransf_7 PF13508.7 CDW59715.1 - 0.018 15.5 0.0 0.065 13.7 0.0 2.0 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_25 PF13481.6 CDW59715.1 - 0.027 14.0 0.0 5.1 6.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain SBP_bac_8 PF13416.6 CDW59715.1 - 0.029 14.2 0.0 0.092 12.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein NACHT PF05729.12 CDW59715.1 - 0.038 13.9 0.0 7 6.5 0.0 2.4 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 CDW59715.1 - 0.049 13.6 0.7 6.9 6.7 0.0 3.4 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 CDW59715.1 - 0.057 13.1 0.0 6.9 6.3 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 CDW59715.1 - 0.071 12.3 0.0 0.88 8.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PRK PF00485.18 CDW59715.1 - 0.085 12.6 0.0 6.3 6.5 0.0 2.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family cobW PF02492.19 CDW59715.1 - 0.1 12.2 0.0 19 4.8 0.0 2.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 CDW59715.1 - 0.13 11.5 1.9 6.1 6.0 0.0 2.8 3 0 0 3 3 2 0 NB-ARC domain AAA_17 PF13207.6 CDW59715.1 - 0.19 12.2 5.0 47 4.4 0.1 4.5 5 0 0 5 5 3 0 AAA domain Ribosomal_S30AE PF02482.19 CDW59716.1 - 4.1e-30 104.4 1.7 5.5e-29 100.8 0.6 2.7 2 0 0 2 2 2 1 Sigma 54 modulation protein / S30EA ribosomal protein Ribosom_S30AE_C PF16321.5 CDW59716.1 - 2e-26 91.4 0.0 5.4e-26 90.1 0.0 1.8 1 0 0 1 1 1 1 Sigma 54 modulation/S30EA ribosomal protein C terminus Y2_Tnp PF04986.13 CDW59716.1 - 3.2e-11 43.6 3.1 3.2e-11 43.6 0.1 2.4 2 1 1 3 3 3 1 Putative transposase Helicase_C PF00271.31 CDW59716.1 - 0.007 16.7 0.1 0.04 14.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PRANC PF09372.10 CDW59716.1 - 0.0084 16.4 2.5 0.0084 16.4 2.5 2.7 3 0 0 3 3 3 1 PRANC domain Ribosomal_S20p PF01649.18 CDW59716.1 - 8.3 7.1 9.1 2.3 8.9 0.8 3.1 3 1 0 3 3 3 0 Ribosomal protein S20 Adaptin_N PF01602.20 CDW59717.1 - 1.4e-131 439.7 9.2 1.7e-131 439.4 9.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Glyco_hydr_116N PF12215.8 CDW59717.1 - 1.1e-46 159.7 0.0 1.9e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Alpha_adaptinC2 PF02883.20 CDW59717.1 - 6.8e-18 65.0 1.4 1.7e-17 63.7 1.4 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 CDW59717.1 - 1.1e-08 35.3 3.9 9.6e-07 29.0 0.4 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CDW59717.1 - 0.0049 17.2 0.3 0.91 10.0 0.0 3.9 3 1 1 4 4 4 1 HEAT repeats RIX1 PF08167.12 CDW59717.1 - 0.012 15.4 1.2 2.1 8.1 0.2 3.4 2 1 0 2 2 2 0 rRNA processing/ribosome biogenesis Pox_VLTF3 PF04947.14 CDW59717.1 - 0.013 15.2 0.6 1.4 8.6 0.3 2.7 2 0 0 2 2 2 0 Poxvirus Late Transcription Factor VLTF3 like LBP_BPI_CETP_C PF02886.17 CDW59718.1 - 8.6e-31 107.2 0.3 1.8e-30 106.1 0.3 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 CDW59718.1 - 3.9e-07 29.8 0.0 8.5e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Sarcolipin PF05366.11 CDW59718.1 - 2.1 8.1 4.3 70 3.2 0.0 3.6 4 0 0 4 4 4 0 Sarcolipin FAM167 PF11652.8 CDW59719.1 - 0.08 13.4 0.3 0.22 12.0 0.3 1.9 1 0 0 1 1 1 0 FAM167 DUF2510 PF10708.9 CDW59720.1 - 0.52 10.1 3.0 0.89 9.4 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2510) rve PF00665.26 CDW59721.1 - 1.9e-05 24.8 0.0 4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Beta-Casp PF10996.8 CDW59722.1 - 1.9e-26 92.5 0.0 7.8e-26 90.5 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 CDW59722.1 - 2.6e-16 59.3 0.0 6.1e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 CDW59722.1 - 2.2e-09 37.6 0.1 4e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CDW59722.1 - 6.1e-07 29.1 0.0 1.6e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CDW59722.1 - 0.00015 21.4 0.0 0.0012 18.4 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CDW59722.1 - 0.027 14.3 0.0 0.072 13.0 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Thiolase_N PF00108.23 CDW59723.1 - 2.1e-85 286.2 0.0 3.8e-85 285.4 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CDW59723.1 - 6.8e-47 158.2 3.3 1.5e-46 157.0 0.6 2.5 3 0 0 3 3 3 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 CDW59723.1 - 0.0049 17.0 0.2 2.6 8.3 0.0 3.2 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 CDW59723.1 - 0.017 14.7 0.0 0.28 10.7 0.0 2.4 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain Arc PF03869.14 CDW59723.1 - 0.085 12.7 0.0 18 5.3 0.0 2.4 2 0 0 2 2 2 0 Arc-like DNA binding domain PIN_5 PF08745.11 CDW59724.1 - 0.15 11.4 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 PINc domain ribonuclease BSD PF03909.17 CDW59725.1 - 2.4e-12 46.7 0.2 2.4e-12 46.7 0.2 1.6 2 0 0 2 2 2 1 BSD domain TruD PF01142.18 CDW59725.1 - 0.086 11.6 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 tRNA pseudouridine synthase D (TruD) SRP68 PF16969.5 CDW59726.1 - 1.1e-72 245.9 10.5 7.9e-62 210.0 6.8 2.6 2 1 0 2 2 2 2 RNA-binding signal recognition particle 68 tRNA-synt_2c PF01411.19 CDW59728.1 - 7.3e-242 803.8 0.0 1.2e-241 803.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 CDW59728.1 - 6e-32 110.9 3.1 1.5e-31 109.6 3.1 1.8 1 0 0 1 1 1 1 DHHA1 domain tRNA_SAD PF07973.14 CDW59728.1 - 3.7e-18 65.3 1.2 9.9e-18 64.0 0.2 2.4 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF1319 PF07028.11 CDW59728.1 - 0.0059 16.8 2.3 0.012 15.8 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1319) Leu_zip PF15294.6 CDW59728.1 - 0.0062 16.1 0.5 0.013 15.0 0.5 1.5 1 0 0 1 1 1 1 Leucine zipper Peptidase_M23 PF01551.22 CDW59728.1 - 0.096 12.9 2.7 5.7 7.2 0.2 2.7 2 0 0 2 2 2 0 Peptidase family M23 Spc7 PF08317.11 CDW59728.1 - 0.45 9.3 5.1 0.22 10.3 1.6 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein ADIP PF11559.8 CDW59728.1 - 0.57 10.3 6.4 0.64 10.1 2.1 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding LPP PF04728.13 CDW59728.1 - 1.1 9.7 4.0 18 5.8 0.0 3.0 2 0 0 2 2 2 0 Lipoprotein leucine-zipper RecX PF02631.16 CDW59729.1 - 4.8e-31 107.8 0.3 1.3e-30 106.3 0.1 1.7 2 0 0 2 2 2 1 RecX family HTH_21 PF13276.6 CDW59729.1 - 0.081 13.1 0.1 0.35 11.0 0.0 2.1 2 0 0 2 2 2 0 HTH-like domain RecA PF00154.21 CDW59730.1 - 1.2e-141 470.7 2.5 2e-141 470.0 2.5 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein CinA PF02464.17 CDW59730.1 - 1.3e-56 190.5 3.3 3.2e-56 189.2 3.3 1.7 1 0 0 1 1 1 1 Competence-damaged protein Rad51 PF08423.11 CDW59730.1 - 6.7e-12 45.2 0.6 1.9e-11 43.7 0.6 1.7 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 CDW59730.1 - 2.4e-09 36.9 0.3 7.1e-08 32.1 0.3 2.7 1 1 0 1 1 1 1 KaiC AAA_24 PF13479.6 CDW59730.1 - 1.5e-05 24.8 0.0 2.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CDW59730.1 - 8.7e-05 22.5 0.0 0.00019 21.5 0.0 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 CDW59730.1 - 0.00083 19.8 0.0 0.0015 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CDW59730.1 - 0.0015 18.2 0.6 0.068 12.7 0.6 2.6 1 1 0 1 1 1 1 AAA domain AAA_35 PF14516.6 CDW59730.1 - 0.02 13.8 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain CbiA PF01656.23 CDW59730.1 - 0.026 14.6 0.0 0.061 13.4 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain PAXNEB PF05625.11 CDW59730.1 - 0.027 13.6 0.6 0.042 13.0 0.6 1.2 1 0 0 1 1 1 0 PAXNEB protein CobU PF02283.16 CDW59730.1 - 0.059 12.9 0.0 0.2 11.2 0.0 1.9 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase MobB PF03205.14 CDW59730.1 - 0.065 13.1 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 CDW59730.1 - 0.07 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDW59730.1 - 0.077 13.4 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ribosomal_S24e PF01282.19 CDW59730.1 - 0.08 12.9 0.0 0.9 9.5 0.0 2.6 2 0 0 2 2 2 0 Ribosomal protein S24e AAA_14 PF13173.6 CDW59730.1 - 0.086 12.9 0.1 0.3 11.1 0.0 2.1 3 0 0 3 3 2 0 AAA domain TK PF00265.18 CDW59730.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Thymidine kinase SLT_2 PF13406.6 CDW59731.1 - 2.8e-92 309.0 0.1 3.3e-92 308.8 0.1 1.0 1 0 0 1 1 1 1 Transglycosylase SLT domain Glucosaminidase PF01832.20 CDW59731.1 - 0.023 15.2 0.0 0.04 14.4 0.0 1.6 1 0 0 1 1 1 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EII-GUT PF03608.13 CDW59732.1 - 1.6e-73 246.1 0.7 1.6e-73 246.1 0.7 2.0 2 0 0 2 2 2 1 PTS system enzyme II sorbitol-specific factor DeoRC PF00455.22 CDW59732.1 - 3.3e-51 173.4 0.6 6.7e-51 172.4 0.6 1.5 1 0 0 1 1 1 1 DeoR C terminal sensor domain adh_short PF00106.25 CDW59732.1 - 8.1e-48 162.5 0.1 3e-47 160.6 0.1 2.0 2 0 0 2 2 2 1 short chain dehydrogenase EIIBC-GUT_N PF03612.14 CDW59732.1 - 8.8e-46 156.0 1.1 2.1e-45 154.7 0.4 1.9 2 0 0 2 2 2 1 Sorbitol phosphotransferase enzyme II N-terminus adh_short_C2 PF13561.6 CDW59732.1 - 1.1e-39 136.4 0.0 2.9e-39 135.0 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PTSIIA_gutA PF03829.13 CDW59732.1 - 4.9e-35 119.8 0.0 1.1e-34 118.6 0.0 1.5 1 0 0 1 1 1 1 PTS system glucitol/sorbitol-specific IIA component EIIBC-GUT_C PF07663.11 CDW59732.1 - 1.5e-34 118.0 3.7 6.1e-34 116.1 3.7 2.0 1 0 0 1 1 1 1 Sorbitol phosphotransferase enzyme II C-terminus HTH_DeoR PF08220.12 CDW59732.1 - 9e-21 73.4 0.1 1.6e-20 72.6 0.1 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CDW59732.1 - 2.2e-07 30.7 0.0 6.6e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 HTH domain 3HCDH_N PF02737.18 CDW59732.1 - 0.0097 15.8 0.3 0.019 14.9 0.3 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain KR PF08659.10 CDW59732.1 - 0.01 15.8 0.5 0.024 14.6 0.5 1.6 1 0 0 1 1 1 0 KR domain FeoC PF09012.10 CDW59732.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator Gate PF07670.14 CDW59732.1 - 0.014 15.6 2.5 0.014 15.6 2.5 2.8 3 0 0 3 3 2 0 Nucleoside recognition HTH_5 PF01022.20 CDW59732.1 - 0.038 13.8 0.0 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family Put_DNA-bind_N PF06971.13 CDW59732.1 - 0.048 13.7 0.0 0.16 12.0 0.0 1.9 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus E3_UFM1_ligase PF09743.9 CDW59732.1 - 0.069 12.8 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 E3 UFM1-protein ligase 1 Epimerase PF01370.21 CDW59732.1 - 0.14 11.6 0.0 2 7.8 0.1 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family HTH_20 PF12840.7 CDW59732.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Type2_restr_D3 PF16902.5 CDW59732.1 - 0.15 12.0 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 Type-2 restriction enzyme D3 domain HTH_AsnC-type PF13404.6 CDW59732.1 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain GntR PF00392.21 CDW59732.1 - 0.17 11.6 0.0 0.56 9.9 0.0 1.9 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family CitMHS PF03600.16 CDW59732.1 - 9 5.4 17.0 16 4.6 15.9 1.8 1 1 1 2 2 2 0 Citrate transporter SIS PF01380.22 CDW59733.1 - 2.2e-29 102.0 0.1 4.4e-29 101.0 0.1 1.5 2 0 0 2 2 2 1 SIS domain CBS PF00571.28 CDW59733.1 - 4e-10 40.0 0.1 0.00051 20.4 0.0 2.9 3 0 0 3 3 3 2 CBS domain Thiolase_C PF02803.18 CDW59733.1 - 0.047 13.4 0.4 0.27 10.9 0.1 2.2 1 1 1 2 2 2 0 Thiolase, C-terminal domain Sigma54_activat PF00158.26 CDW59734.1 - 4.5e-67 224.9 0.0 1e-66 223.8 0.0 1.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDW59734.1 - 3.9e-23 82.1 0.0 8.6e-23 81.0 0.0 1.6 1 1 0 1 1 1 1 Sigma-54 interaction domain GAF PF01590.26 CDW59734.1 - 6.2e-10 39.8 0.1 1.6e-09 38.5 0.0 1.7 2 0 0 2 2 2 1 GAF domain Mg_chelatase PF01078.21 CDW59734.1 - 9.4e-08 31.7 0.2 0.0033 16.8 0.1 2.5 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI GAF_2 PF13185.6 CDW59734.1 - 2.1e-07 31.3 1.0 9.4e-07 29.2 0.3 2.1 2 0 0 2 2 2 1 GAF domain MCM PF00493.23 CDW59734.1 - 5.7e-06 25.6 0.0 9.9e-06 24.8 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain AAA PF00004.29 CDW59734.1 - 6.8e-06 26.5 0.0 1.3e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW59734.1 - 9.1e-06 25.7 0.0 2.1e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) GAF_3 PF13492.6 CDW59734.1 - 0.00099 19.5 0.0 0.0027 18.1 0.0 1.7 1 0 0 1 1 1 1 GAF domain IstB_IS21 PF01695.17 CDW59734.1 - 0.036 13.8 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 CDW59734.1 - 0.037 13.8 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDW59734.1 - 0.044 14.2 0.9 0.17 12.2 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain AAA_2 PF07724.14 CDW59734.1 - 0.073 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DBD_HTH PF18430.1 CDW59734.1 - 0.085 12.6 0.1 0.25 11.2 0.1 1.7 1 0 0 1 1 1 0 Putative DNA-binding domain T2SSE PF00437.20 CDW59734.1 - 0.13 11.3 0.0 0.36 9.8 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 CDW59734.1 - 0.16 12.3 0.3 6.7 7.0 0.0 2.4 1 1 0 2 2 2 0 AAA domain Rubredoxin PF00301.20 CDW59735.1 - 4.9e-21 74.5 2.5 8.7e-21 73.7 2.5 1.4 1 0 0 1 1 1 1 Rubredoxin Flavodoxin_1 PF00258.25 CDW59735.1 - 9.7e-13 48.5 0.0 1.6e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin Lactamase_B PF00753.27 CDW59735.1 - 2.4e-11 44.0 0.2 3.2e-11 43.6 0.2 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CDW59735.1 - 1.2e-06 28.2 0.3 2.4e-06 27.2 0.3 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CDW59735.1 - 0.01 15.2 0.0 0.019 14.4 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain YliH PF10799.8 CDW59735.1 - 0.021 14.7 0.1 0.065 13.2 0.0 1.8 2 0 0 2 2 2 0 Biofilm formation protein (YliH/bssR) DnaT PF17948.1 CDW59735.1 - 0.041 13.6 0.1 0.11 12.2 0.1 1.7 1 0 0 1 1 1 0 DnaT DNA-binding domain Lactamase_B_3 PF13483.6 CDW59735.1 - 0.065 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Pyr_redox_2 PF07992.14 CDW59736.1 - 1.2e-45 156.1 0.0 1.6e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rbx_binding PF18113.1 CDW59736.1 - 1.7e-21 75.8 0.1 3.9e-21 74.6 0.0 1.7 2 0 0 2 2 1 1 Rubredoxin binding C-terminal domain Pyr_redox PF00070.27 CDW59736.1 - 3.2e-17 62.8 0.0 6.7e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW59736.1 - 2.5e-14 53.2 0.0 3e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CDW59736.1 - 5.1e-10 39.5 1.4 0.017 14.7 0.4 3.1 2 1 1 3 3 3 3 FAD dependent oxidoreductase K_oxygenase PF13434.6 CDW59736.1 - 5.1e-08 32.4 0.0 3.9e-06 26.2 0.0 2.2 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CDW59736.1 - 5.6e-06 25.3 1.7 0.15 10.7 0.0 3.1 2 1 1 3 3 3 3 HI0933-like protein NAD_binding_9 PF13454.6 CDW59736.1 - 0.00016 21.7 2.0 0.47 10.4 0.0 3.0 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 CDW59736.1 - 0.00047 20.6 0.0 0.00088 19.7 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 CDW59736.1 - 0.0014 18.5 0.0 0.0023 17.8 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 CDW59736.1 - 0.0028 17.0 0.1 0.0047 16.3 0.1 1.3 1 0 0 1 1 1 1 ThiF family GIDA PF01134.22 CDW59736.1 - 0.0041 16.2 0.2 0.1 11.6 0.3 2.3 2 1 0 2 2 2 1 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CDW59736.1 - 0.0077 15.3 1.3 1.8 7.5 0.0 2.2 1 1 0 2 2 2 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 CDW59736.1 - 0.0079 15.5 1.6 0.024 13.9 0.3 2.2 2 1 1 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 CDW59736.1 - 0.031 14.5 0.0 0.073 13.3 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CDW59736.1 - 0.037 13.4 0.4 1.9 7.7 0.4 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase TrkA_N PF02254.18 CDW59736.1 - 0.065 13.5 0.1 0.18 12.1 0.1 1.8 1 1 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 CDW59736.1 - 0.1 12.2 1.1 0.2 11.3 0.3 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA HypF_C PF17788.1 CDW59737.1 - 1.2e-32 112.7 0.2 1.8e-32 112.0 0.2 1.3 1 0 0 1 1 1 1 HypF Kae1-like domain His_Phos_2 PF00328.22 CDW59739.1 - 6.4e-11 42.2 0.1 6.8e-09 35.6 0.0 2.1 1 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) ABC_tran PF00005.27 CDW59740.1 - 1.7e-40 138.7 0.0 2.5e-26 92.8 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CDW59740.1 - 6.3e-18 65.6 0.2 2.6e-07 30.8 0.0 3.1 2 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW59740.1 - 5.6e-12 45.2 0.9 1.7e-05 24.4 0.1 2.3 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 CDW59740.1 - 2.1e-11 44.2 0.5 5.2e-05 23.1 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain SMC_N PF02463.19 CDW59740.1 - 1.1e-10 41.4 0.1 0.0036 16.8 0.0 3.1 2 1 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDW59740.1 - 2.2e-10 40.9 0.0 1e-05 25.8 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CDW59740.1 - 7.9e-10 39.6 0.1 0.001 19.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CDW59740.1 - 1.2e-08 35.1 0.2 0.0027 17.6 0.0 2.3 1 1 1 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 CDW59740.1 - 1.6e-08 35.2 0.1 0.0023 18.3 0.0 2.3 1 1 1 2 2 2 2 AAA ATPase domain NACHT PF05729.12 CDW59740.1 - 4.7e-07 29.9 0.0 0.0063 16.4 0.0 2.3 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 CDW59740.1 - 2.6e-06 27.1 0.0 0.055 13.0 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 CDW59740.1 - 8e-06 26.1 0.2 0.17 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CDW59740.1 - 1e-05 25.6 0.4 0.25 11.4 0.0 2.8 3 0 0 3 3 2 2 50S ribosome-binding GTPase NB-ARC PF00931.22 CDW59740.1 - 1.5e-05 24.3 0.0 0.019 14.2 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain AAA_18 PF13238.6 CDW59740.1 - 1.7e-05 25.4 0.0 0.29 11.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CDW59740.1 - 2e-05 24.4 0.0 0.11 12.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CDW59740.1 - 2.1e-05 24.4 0.6 0.0087 15.8 0.0 3.0 2 1 1 3 3 3 1 IstB-like ATP binding protein AAA_7 PF12775.7 CDW59740.1 - 4.6e-05 23.0 0.1 0.067 12.7 0.0 2.3 1 1 1 2 2 2 2 P-loop containing dynein motor region TniB PF05621.11 CDW59740.1 - 6.7e-05 22.4 0.1 2.7 7.4 0.0 3.1 2 1 1 3 3 3 1 Bacterial TniB protein ABC_ATPase PF09818.9 CDW59740.1 - 7.4e-05 21.7 1.1 0.19 10.5 0.0 3.2 3 1 0 3 3 3 1 Predicted ATPase of the ABC class G-alpha PF00503.20 CDW59740.1 - 0.00013 21.3 0.0 0.22 10.6 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Mg_chelatase PF01078.21 CDW59740.1 - 0.00014 21.3 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI DUF87 PF01935.17 CDW59740.1 - 0.00021 21.5 0.2 0.62 10.1 0.0 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_5 PF07728.14 CDW59740.1 - 0.00022 21.3 0.2 0.092 12.7 0.0 2.7 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 CDW59740.1 - 0.00023 20.9 0.0 0.8 9.4 0.0 2.6 3 0 0 3 3 2 2 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 CDW59740.1 - 0.00029 20.5 0.5 0.33 10.5 0.0 2.9 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain ATPase PF06745.13 CDW59740.1 - 0.00035 20.0 0.2 2.4 7.5 0.0 3.3 3 0 0 3 3 3 1 KaiC FtsK_SpoIIIE PF01580.18 CDW59740.1 - 0.00041 19.8 0.0 0.26 10.6 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 CDW59740.1 - 0.00055 20.0 0.3 0.8 9.7 0.1 2.4 2 0 0 2 2 2 2 Dynamin family RNA_helicase PF00910.22 CDW59740.1 - 0.0007 20.0 0.0 1.5 9.2 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 CDW59740.1 - 0.0012 18.6 0.5 0.88 9.3 0.0 2.6 3 0 0 3 3 3 1 AAA domain cobW PF02492.19 CDW59740.1 - 0.0022 17.6 0.3 0.18 11.4 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 CDW59740.1 - 0.0025 17.7 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.12 CDW59740.1 - 0.0031 16.8 0.1 1.8 7.8 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_28 PF13521.6 CDW59740.1 - 0.0038 17.5 0.1 3.7 7.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CDW59740.1 - 0.0065 16.5 0.0 4.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 CDW59740.1 - 0.007 15.5 0.0 0.46 9.5 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein Ploopntkinase3 PF18751.1 CDW59740.1 - 0.011 15.7 0.1 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MeaB PF03308.16 CDW59740.1 - 0.012 14.6 0.0 1.6 7.6 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_27 PF13514.6 CDW59740.1 - 0.013 15.1 0.1 0.48 10.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CDW59740.1 - 0.014 15.1 0.0 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_14 PF13173.6 CDW59740.1 - 0.017 15.1 0.0 4.3 7.4 0.0 2.7 1 1 1 2 2 2 0 AAA domain ATPase_2 PF01637.18 CDW59740.1 - 0.022 14.7 0.1 9.9 6.0 0.0 3.0 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Roc PF08477.13 CDW59740.1 - 0.022 14.9 0.0 7.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 CDW59740.1 - 0.023 14.4 0.9 2.2 7.9 0.1 2.6 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 CDW59740.1 - 0.026 14.4 0.0 7.7 6.4 0.0 2.5 2 0 0 2 2 2 0 NTPase ATP-synt_ab PF00006.25 CDW59740.1 - 0.03 14.0 0.0 3.1 7.4 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_10 PF12846.7 CDW59740.1 - 0.031 13.2 0.0 6.2 5.6 0.0 2.8 3 0 0 3 3 3 0 AAA-like domain MobB PF03205.14 CDW59740.1 - 0.034 14.1 0.1 6.1 6.8 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.20 CDW59740.1 - 0.04 13.8 0.1 5 7.0 0.0 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF4934 PF16288.5 CDW59740.1 - 0.042 13.8 0.0 2.1 8.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4934) DUF815 PF05673.13 CDW59740.1 - 0.042 13.0 0.0 2.3 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_13 PF13166.6 CDW59740.1 - 0.046 12.4 0.0 0.24 10.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 CDW59740.1 - 0.057 12.9 0.0 3.5 7.0 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA PF00004.29 CDW59740.1 - 0.093 13.2 0.7 4.9 7.6 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 CDW59740.1 - 0.12 11.9 0.0 14 5.2 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B PIF1 PF05970.14 CDW59740.1 - 0.15 11.2 0.0 6.9 5.7 0.0 2.4 3 0 0 3 3 2 0 PIF1-like helicase AAA_17 PF13207.6 CDW59740.1 - 0.18 12.2 0.1 32 4.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain Ribosomal_L17 PF01196.19 CDW59741.1 - 8.2e-40 135.6 0.8 9.2e-40 135.5 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L17 RNA_pol_A_CTD PF03118.15 CDW59742.1 - 2.4e-28 97.7 3.8 4.8e-28 96.7 3.8 1.5 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain RNA_pol_L PF01193.24 CDW59742.1 - 1.4e-25 88.5 0.1 4e-25 87.0 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 CDW59742.1 - 1.7e-23 83.1 1.9 6.3e-23 81.3 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain DUF4843 PF16132.5 CDW59742.1 - 0.025 14.1 0.2 0.11 12.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4843) Ribosomal_S11 PF00411.19 CDW59743.1 - 1.1e-50 170.6 1.4 1.3e-50 170.4 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_L18p PF00861.22 CDW59743.1 - 0.061 13.7 0.3 0.092 13.1 0.3 1.2 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast LPD7 PF18821.1 CDW59743.1 - 0.07 13.3 0.2 0.13 12.4 0.2 1.7 1 1 0 1 1 1 0 Large polyvalent protein-associated domain 7 Ribosomal_S13 PF00416.22 CDW59744.1 - 1.6e-32 112.6 7.0 1e-30 106.8 7.0 2.1 1 1 0 1 1 1 1 Ribosomal protein S13/S18 eIF-1a PF01176.19 CDW59744.1 - 3.1e-09 36.5 0.1 6e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 FbpA PF05833.11 CDW59744.1 - 0.0032 16.3 0.0 0.0034 16.2 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DNA_pol_lambd_f PF10391.9 CDW59744.1 - 0.025 14.4 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda HHH_6 PF14579.6 CDW59744.1 - 0.026 14.8 0.1 0.066 13.5 0.1 1.7 1 1 1 2 2 2 0 Helix-hairpin-helix motif H2TH PF06831.14 CDW59744.1 - 0.034 14.1 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain ADK PF00406.22 CDW59745.1 - 9.2e-59 197.9 0.0 1.1e-58 197.7 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDW59745.1 - 1e-30 107.0 0.1 1.7e-30 106.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 CDW59745.1 - 9.8e-15 54.3 1.3 1.7e-14 53.5 1.3 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 CDW59745.1 - 8.2e-06 26.2 0.1 0.058 13.7 0.0 3.0 2 1 1 3 3 3 2 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 CDW59745.1 - 9.9e-06 25.8 0.0 1.5e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDW59745.1 - 0.00053 20.5 0.1 0.003 18.1 0.0 2.2 2 1 0 2 2 2 1 AAA domain HypA PF01155.19 CDW59745.1 - 0.0019 18.2 0.1 0.003 17.6 0.1 1.3 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 CDW59745.1 - 0.0068 15.9 3.0 0.013 15.0 3.0 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding DUF1451 PF07295.11 CDW59745.1 - 0.086 12.9 4.0 0.095 12.7 2.9 1.5 1 1 0 1 1 1 0 Zinc-ribbon containing domain Rubredoxin_2 PF18073.1 CDW59745.1 - 0.099 12.4 3.6 0.67 9.7 3.6 2.0 1 1 0 1 1 1 0 Rubredoxin metal binding domain Lar_restr_allev PF14354.6 CDW59745.1 - 0.16 12.4 1.3 19 5.7 0.1 2.4 1 1 1 2 2 2 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 CDW59745.1 - 0.21 11.7 1.9 0.4 10.8 1.9 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_13 PF09855.9 CDW59745.1 - 0.42 10.8 1.8 8.5 6.6 1.9 2.2 1 1 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) SecY PF00344.20 CDW59746.1 - 1.4e-106 356.2 22.2 1.6e-106 356.0 22.2 1.0 1 0 0 1 1 1 1 SecY translocase DUF3487 PF11990.8 CDW59746.1 - 0.5 10.3 6.5 2.8 7.9 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3487) Pox_A14 PF05767.12 CDW59746.1 - 0.6 10.3 13.7 0.61 10.3 0.0 3.7 4 1 0 4 4 4 0 Poxvirus virion envelope protein A14 DUF4307 PF14155.6 CDW59746.1 - 9.2 6.1 5.9 4.4 7.2 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4307) Ribosomal_L27A PF00828.19 CDW59747.1 - 6.6e-40 136.7 4.1 8.2e-40 136.4 4.1 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_S8 PF00410.19 CDW59748.1 - 1.7e-45 154.1 0.5 1.2e-44 151.3 0.3 2.2 2 0 0 2 2 2 1 Ribosomal protein S8 Ribosomal_L6 PF00347.23 CDW59748.1 - 2.3e-38 130.7 10.1 1.3e-20 73.8 1.4 3.0 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S5 PF00333.20 CDW59748.1 - 6.8e-33 112.5 2.0 1.9e-32 111.0 2.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CDW59748.1 - 2.6e-28 97.2 0.3 7.5e-28 95.8 0.3 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain TubC_N PF18563.1 CDW59748.1 - 0.02 14.9 0.1 0.067 13.2 0.0 2.0 2 0 0 2 2 2 0 TubC N-terminal docking domain RRM_3 PF08777.11 CDW59748.1 - 0.076 13.1 0.2 6.2 6.9 0.1 2.6 2 0 0 2 2 2 0 RNA binding motif Ribosomal_L14 PF00238.19 CDW59749.1 - 1.7e-48 163.7 1.5 1.7e-48 163.7 1.5 2.8 3 1 1 4 4 4 1 Ribosomal protein L14p/L23e Ribosomal_S17 PF00366.20 CDW59749.1 - 5.6e-32 109.7 3.4 5.6e-32 109.7 3.4 3.1 3 1 1 4 4 4 1 Ribosomal protein S17 ribosomal_L24 PF17136.4 CDW59749.1 - 8.7e-25 86.9 0.5 8.7e-25 86.9 0.5 2.5 2 1 1 3 3 3 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 DUF3320 PF11784.8 CDW59749.1 - 0.071 13.1 0.4 0.21 11.6 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3320) Ribosomal_L16 PF00252.18 CDW59750.1 - 1.2e-45 154.7 1.3 1.3e-45 154.6 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e HIRAN PF08797.11 CDW59750.1 - 0.032 14.2 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 HIRAN domain Ribosomal_L2_C PF03947.18 CDW59751.1 - 4.8e-58 194.8 4.8 6.3e-58 194.5 3.5 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CDW59751.1 - 3.7e-35 119.7 2.1 1.5e-34 117.8 1.2 2.2 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L23 PF00276.20 CDW59752.1 - 1.2e-22 80.1 7.6 1.2e-22 80.0 7.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L23 Herpes_US9 PF06072.11 CDW59752.1 - 0.14 12.0 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 Ribosomal_L4 PF00573.22 CDW59753.1 - 1.5e-67 227.0 1.0 1.7e-67 226.9 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_S10 PF00338.22 CDW59754.1 - 8.8e-27 93.2 0.0 2e-26 92.1 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Ribosomal_L3 PF00297.22 CDW59754.1 - 1.8e-19 70.0 8.1 4.8e-17 62.0 2.0 2.9 2 1 1 3 3 3 2 Ribosomal protein L3 DNase_II PF03265.15 CDW59755.1 - 1.3e-33 116.6 0.0 2.8e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 Deoxyribonuclease II DNase_II PF03265.15 CDW59756.1 - 2e-25 89.8 0.1 2.6e-25 89.4 0.1 1.2 1 0 0 1 1 1 1 Deoxyribonuclease II C1_1 PF00130.22 CDW59757.1 - 2.8e-16 59.1 8.5 8.7e-16 57.6 8.5 1.9 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CDW59757.1 - 0.18 12.1 6.7 0.39 11.1 6.7 1.6 1 0 0 1 1 1 0 C1 domain CENP-T_C PF15511.6 CDW59758.1 - 3.9e-08 33.4 0.1 4.9e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW59758.1 - 2.7e-05 24.5 0.1 3.5e-05 24.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW59758.1 - 5.1e-05 23.5 0.1 8.9e-05 22.7 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW59758.1 - 6.3e-05 23.1 0.1 8.9e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 CDW59758.1 - 0.00011 22.5 0.2 0.00012 22.4 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 CDW59758.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 CDW59758.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 CDW59758.1 - 0.15 12.6 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone_H2A_C PF16211.5 CDW59759.1 - 3.8e-19 68.1 0.4 7.6e-19 67.1 0.4 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW59759.1 - 4.7e-16 59.3 0.0 6e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59759.1 - 7.8e-05 22.9 0.0 0.00011 22.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDW59760.1 - 2.4e-20 73.2 0.2 2.9e-20 73.0 0.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59760.1 - 1.1e-05 25.6 0.0 2.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW59760.1 - 0.0068 16.5 0.1 0.0075 16.3 0.1 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 CDW59760.1 - 0.012 16.0 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 CDW59761.1 - 1.7e-50 170.7 3.7 1.9e-50 170.6 3.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW59761.1 - 6.7e-05 23.5 0.8 7.8e-05 23.3 0.8 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW59761.1 - 7e-05 22.9 0.8 0.00011 22.3 0.2 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW59761.1 - 0.0024 18.2 0.1 0.0038 17.6 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW59761.1 - 0.015 15.4 0.2 0.031 14.4 0.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW59761.1 - 0.05 13.9 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 CDW59762.1 - 3.9e-08 33.4 0.1 4.9e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW59762.1 - 2.7e-05 24.5 0.1 3.5e-05 24.1 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW59762.1 - 5.1e-05 23.5 0.1 8.9e-05 22.7 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW59762.1 - 6.3e-05 23.1 0.1 8.9e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 CDW59762.1 - 0.00011 22.5 0.2 0.00012 22.4 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 CDW59762.1 - 0.0012 18.8 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 CDW59762.1 - 0.01 15.9 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 CDW59762.1 - 0.15 12.6 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A PALP PF00291.25 CDW59763.1 - 2.5e-12 46.8 0.0 2.9e-12 46.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Gelsolin PF00626.22 CDW59766.1 - 2e-46 155.7 0.1 8.4e-17 60.8 0.0 4.4 4 0 0 4 4 4 4 Gelsolin repeat VHP PF02209.19 CDW59766.1 - 3.9e-09 36.4 0.1 1e-08 35.1 0.1 1.8 1 0 0 1 1 1 1 Villin headpiece domain CutA1 PF03091.15 CDW59766.1 - 0.16 11.8 0.1 6.5 6.7 0.0 2.8 3 0 0 3 3 3 0 CutA1 divalent ion tolerance protein Mito_carr PF00153.27 CDW59767.1 - 3.5e-13 49.3 0.1 4e-13 49.1 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial carrier protein GATase PF00117.28 CDW59768.1 - 4.8e-42 143.9 0.0 7e-42 143.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 CDW59768.1 - 1.4e-14 53.9 0.0 3.3e-14 52.7 0.0 1.7 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 CDW59768.1 - 3.5e-09 36.2 0.1 1.1e-06 27.9 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CDW59768.1 - 4.3e-09 36.4 0.0 9.3e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 CDW59768.1 - 1.5e-05 24.0 0.1 9.6e-05 21.3 0.0 2.0 2 0 0 2 2 2 1 tRNA methyl transferase Asn_synthase PF00733.21 CDW59768.1 - 0.0031 17.3 0.0 0.02 14.5 0.0 2.0 2 0 0 2 2 2 1 Asparagine synthase QueC PF06508.13 CDW59768.1 - 0.006 16.1 0.0 2.4 7.6 0.0 2.6 3 0 0 3 3 3 2 Queuosine biosynthesis protein QueC ThiI PF02568.14 CDW59768.1 - 0.019 14.5 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) SNO PF01174.19 CDW59768.1 - 0.022 14.6 0.0 0.16 11.8 0.0 2.2 1 1 0 1 1 1 0 SNO glutamine amidotransferase family PAPS_reduct PF01507.19 CDW59768.1 - 0.023 14.7 0.0 0.05 13.7 0.0 1.5 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.20 CDW59768.1 - 0.097 12.4 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 PP-loop family IMPDH PF00478.25 CDW59769.1 - 3.9e-162 539.1 9.0 4.4e-162 538.9 9.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CDW59769.1 - 3.6e-17 62.5 3.2 5.8e-09 36.3 0.1 3.6 2 1 1 3 3 3 2 CBS domain NMO PF03060.15 CDW59769.1 - 3.3e-11 43.2 15.2 9.7e-06 25.2 11.1 2.4 1 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 CDW59769.1 - 8.1e-10 38.3 8.2 1.1e-08 34.6 5.8 2.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CDW59769.1 - 0.00024 20.6 4.8 0.0051 16.3 4.8 2.5 1 1 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.17 CDW59769.1 - 0.0023 17.3 6.7 0.0036 16.7 3.2 2.4 2 0 0 2 2 2 1 Thiamine monophosphate synthase Glu_synthase PF01645.17 CDW59769.1 - 0.0023 17.1 6.3 0.0023 17.1 6.3 1.7 2 0 0 2 2 2 1 Conserved region in glutamate synthase ThiG PF05690.14 CDW59769.1 - 0.003 16.9 7.2 0.003 16.9 7.2 2.6 4 0 0 4 4 4 1 Thiazole biosynthesis protein ThiG Radical_SAM PF04055.21 CDW59769.1 - 0.0033 17.8 0.3 0.6 10.5 0.1 2.5 2 1 0 2 2 2 1 Radical SAM superfamily DHO_dh PF01180.21 CDW59769.1 - 0.0044 16.3 2.8 0.0044 16.3 2.8 2.3 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase NanE PF04131.14 CDW59769.1 - 0.0046 16.2 4.0 0.023 13.9 4.0 2.3 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase Aldolase PF01081.19 CDW59769.1 - 0.35 10.3 6.0 0.12 11.7 0.9 2.5 2 1 1 3 3 3 0 KDPG and KHG aldolase G3P_antiterm PF04309.12 CDW59769.1 - 0.49 9.8 3.2 0.4 10.1 0.4 2.2 3 0 0 3 3 3 0 Glycerol-3-phosphate responsive antiterminator Exonuc_VII_L PF02601.15 CDW59770.1 - 4.9e-105 351.4 4.3 6.2e-105 351.1 4.3 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit tRNA_anti_2 PF13742.6 CDW59770.1 - 4.6e-34 116.5 0.2 8.4e-33 112.5 0.0 2.4 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA_anti-codon PF01336.25 CDW59770.1 - 8.4e-10 38.5 0.0 1.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 CDW59770.1 - 0.036 13.8 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 bMG10 PF17973.1 CDW59770.1 - 0.063 13.5 0.1 0.28 11.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial Alpha-2-macroglobulin MG10 domain Pallilysin PF18663.1 CDW59770.1 - 0.083 12.9 0.1 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 Pallilysin beta barrel domain AAA_23 PF13476.6 CDW59770.1 - 2.8 8.4 7.7 2.5 8.5 6.3 1.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CDW59771.1 - 2e-56 189.0 0.1 1e-28 99.7 0.0 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW59771.1 - 5e-31 107.3 0.0 6.5e-16 58.2 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B KH_dom-like PF14714.6 CDW59771.1 - 9.2e-27 93.2 0.0 3.5e-26 91.3 0.0 1.9 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal GTP_EFTU PF00009.27 CDW59771.1 - 4.6e-21 75.3 0.2 3.3e-10 39.8 0.1 4.8 2 2 1 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDW59771.1 - 7.3e-11 42.4 0.1 0.059 13.4 0.0 4.4 2 2 2 4 4 4 2 Dynamin family AIG1 PF04548.16 CDW59771.1 - 1.1e-09 38.0 0.0 1.7e-05 24.2 0.1 2.3 2 0 0 2 2 2 2 AIG1 family RsgA_GTPase PF03193.16 CDW59771.1 - 1e-08 35.2 0.0 0.018 15.0 0.0 4.1 4 0 0 4 4 4 2 RsgA GTPase Ras PF00071.22 CDW59771.1 - 2e-06 27.5 0.0 0.009 15.6 0.0 3.1 2 2 0 2 2 2 2 Ras family Roc PF08477.13 CDW59771.1 - 2.9e-06 27.5 0.0 0.27 11.5 0.0 4.0 3 2 0 3 3 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CDW59771.1 - 9e-05 22.3 0.0 0.26 11.0 0.0 3.0 2 2 1 3 3 3 2 AAA domain ABC_tran PF00005.27 CDW59771.1 - 0.00011 22.7 0.0 0.53 10.8 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_22 PF13401.6 CDW59771.1 - 0.00021 21.6 0.2 1.2 9.4 0.0 3.5 2 2 0 3 3 3 2 AAA domain TniB PF05621.11 CDW59771.1 - 0.00022 20.7 0.0 0.16 11.3 0.0 2.3 2 0 0 2 2 2 2 Bacterial TniB protein cobW PF02492.19 CDW59771.1 - 0.00023 20.8 3.3 0.66 9.5 0.2 3.8 2 2 2 4 4 4 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 CDW59771.1 - 0.0015 18.3 0.0 24 4.7 0.0 3.8 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 CDW59771.1 - 0.002 17.4 0.0 1.2 8.2 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain NTPase_1 PF03266.15 CDW59771.1 - 0.0021 18.0 0.2 2.4 8.0 0.1 3.0 2 1 0 2 2 2 2 NTPase RNA_helicase PF00910.22 CDW59771.1 - 0.0024 18.2 0.0 4.3 7.8 0.0 2.8 3 0 0 3 3 2 2 RNA helicase MeaB PF03308.16 CDW59771.1 - 0.0027 16.7 0.6 6.6 5.6 0.0 3.6 4 0 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SRPRB PF09439.10 CDW59771.1 - 0.0034 16.8 0.0 0.36 10.2 0.0 2.4 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 CDW59771.1 - 0.0044 16.8 0.0 0.6 9.9 0.0 3.5 3 1 1 4 4 4 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 CDW59771.1 - 0.012 16.2 0.0 6.9 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDW59771.1 - 0.017 15.3 0.0 4.7 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 CDW59771.1 - 0.029 14.0 0.1 1.3 8.6 0.0 2.7 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 CDW59771.1 - 0.039 13.7 0.0 11 5.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Nuc_deoxyri_tr2 PF15891.5 CDW59771.1 - 0.039 14.3 2.1 1.5 9.2 0.0 2.6 3 0 0 3 3 2 0 Nucleoside 2-deoxyribosyltransferase like AAA_25 PF13481.6 CDW59771.1 - 0.042 13.4 1.0 21 4.6 0.1 3.8 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 CDW59771.1 - 0.049 14.0 0.4 17 5.8 0.0 3.2 2 2 0 2 2 2 0 AAA ATPase domain Ploopntkinase3 PF18751.1 CDW59771.1 - 0.11 12.4 0.0 2 8.3 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MMR_HSR1_Xtn PF16897.5 CDW59771.1 - 0.14 12.2 0.0 4.1 7.5 0.0 2.3 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain PQQ_2 PF13360.6 CDW59772.1 - 1.7e-64 217.7 17.1 7.1e-53 179.6 9.1 2.6 1 1 2 3 3 3 3 PQQ-like domain PQQ PF01011.21 CDW59772.1 - 8.7e-40 132.8 8.9 8.7e-07 28.6 0.0 7.1 8 0 0 8 8 8 5 PQQ enzyme repeat PQQ_3 PF13570.6 CDW59772.1 - 3.5e-39 132.3 18.2 5.4e-07 29.9 0.0 8.5 8 0 0 8 8 8 8 PQQ-like domain ANAPC4_WD40 PF12894.7 CDW59772.1 - 0.097 13.0 0.2 19 5.6 0.0 4.0 4 2 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Biotin_lipoyl_2 PF13533.6 CDW59772.1 - 0.12 12.2 1.3 22 5.0 0.1 3.7 4 0 0 4 4 4 0 Biotin-lipoyl like Flavodoxin_4 PF12682.7 CDW59772.1 - 0.13 11.9 0.0 0.47 10.2 0.0 1.8 2 0 0 2 2 2 0 Flavodoxin TPR_21 PF09976.9 CDW59773.1 - 2.8e-54 183.8 10.2 2.8e-54 183.8 10.2 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain tRNA-synt_His PF13393.6 CDW59773.1 - 5.2e-47 160.6 2.6 1.5e-46 159.1 0.0 2.4 2 1 1 3 3 3 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 CDW59773.1 - 1.4e-42 145.7 0.0 4.7e-42 144.0 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDW59773.1 - 1.7e-10 40.9 0.5 9.7e-10 38.5 0.0 2.3 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2 PF00152.20 CDW59773.1 - 0.0013 17.9 0.1 0.29 10.2 0.0 3.1 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) TPR_19 PF14559.6 CDW59773.1 - 0.0031 18.0 4.4 0.0031 18.0 4.4 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat T6SS_VasJ PF16989.5 CDW59773.1 - 0.016 14.7 2.4 0.038 13.4 2.4 1.6 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ tRNA-synt_2d PF01409.20 CDW59773.1 - 0.018 14.5 0.0 0.13 11.7 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Amidohydro_2 PF04909.14 CDW59773.1 - 0.044 13.6 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase DUF883 PF05957.13 CDW59773.1 - 1.8 9.2 6.1 4.3 8.0 0.6 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) TPR_6 PF13174.6 CDW59773.1 - 5.6 7.8 6.0 27 5.7 0.1 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat GcpE PF04551.14 CDW59774.1 - 4e-130 434.0 0.2 5.1e-130 433.6 0.2 1.1 1 0 0 1 1 1 1 GcpE protein DUF4115 PF13464.6 CDW59774.1 - 2e-23 82.4 0.0 4.9e-23 81.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4115) HTH_25 PF13413.6 CDW59774.1 - 7.1e-15 54.6 0.6 2e-14 53.2 0.6 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CDW59774.1 - 1.2e-08 35.2 0.8 5.2e-08 33.1 0.8 2.1 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 CDW59774.1 - 2e-07 31.0 0.0 4.8e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CDW59774.1 - 3.7e-07 30.1 0.0 9.6e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4614 PF15391.6 CDW59774.1 - 8.3 6.4 12.3 51 3.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Radical_SAM PF04055.21 CDW59775.1 - 1.3e-18 68.0 0.1 3.1e-18 66.7 0.1 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 CDW59775.1 - 0.0014 18.8 0.0 0.0032 17.6 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain NDK PF00334.19 CDW59776.1 - 5.2e-54 181.9 0.0 5.7e-54 181.8 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Transgly PF00912.22 CDW59777.1 - 9.6e-51 171.8 0.0 1.4e-50 171.2 0.0 1.3 1 0 0 1 1 1 1 Transglycosylase bMG10 PF17973.1 CDW59777.1 - 2.1e-20 73.3 0.0 4.1e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain BiPBP_C PF06832.12 CDW59777.1 - 5.3e-18 64.8 0.1 1e-16 60.7 0.0 2.9 2 0 0 2 2 2 1 Penicillin-Binding Protein C-terminus Family Transpeptidase PF00905.22 CDW59777.1 - 1.1e-10 41.2 0.0 3e-10 39.8 0.0 1.6 1 1 0 1 1 1 1 Penicillin binding protein transpeptidase domain TED_complement PF07678.14 CDW59777.1 - 0.04 12.9 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 A-macroglobulin TED domain DUF11 PF01345.18 CDW59777.1 - 0.14 12.5 0.1 0.72 10.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF11 Glyco_transf_49 PF13896.6 CDW59779.1 - 1.6e-51 175.6 0.4 1.6e-51 175.6 0.4 2.2 2 1 0 2 2 2 1 Glycosyl-transferase for dystroglycan Glyco_transf_8 PF01501.20 CDW59779.1 - 4.7e-19 68.9 0.9 4.7e-19 68.9 0.9 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 CDW59779.1 - 0.0011 18.4 0.1 0.0027 17.2 0.1 1.6 1 0 0 1 1 1 1 Glucosyltransferase 24 SRR PF07709.11 CDW59779.1 - 0.081 13.3 0.2 75 4.4 0.0 3.7 3 0 0 3 3 3 0 Seven Residue Repeat Tetraspanin PF00335.20 CDW59780.1 - 1.8e-18 67.1 15.9 3e-18 66.4 15.9 1.3 1 1 0 1 1 1 1 Tetraspanin family RAM PF15320.6 CDW59780.1 - 8.7e-09 35.9 0.0 1.5e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 mRNA cap methylation, RNMT-activating mini protein FA_desaturase PF00487.24 CDW59780.1 - 0.0063 16.4 0.4 0.011 15.6 0.4 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Pantoate_transf PF02548.15 CDW59780.1 - 0.013 14.9 0.1 0.019 14.3 0.1 1.1 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase DUF4131 PF13567.6 CDW59780.1 - 0.89 9.2 4.0 0.56 9.8 2.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2070 PF09843.9 CDW59780.1 - 2.2 6.5 5.9 2.9 6.1 5.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ac76 PF05814.11 CDW59780.1 - 8.6 6.5 10.0 1.2 9.1 6.2 1.5 2 0 0 2 2 2 0 Orf76 (Ac76) Herpes_LMP1 PF05297.11 CDW59780.1 - 9.4 5.3 7.3 13 4.9 7.3 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) FGF PF00167.18 CDW59781.1 - 1e-06 28.8 0.1 1.6e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 Fibroblast growth factor MARVEL PF01284.23 CDW59782.1 - 5e-08 33.1 16.7 1.1e-06 28.7 16.7 2.1 1 1 0 1 1 1 1 Membrane-associating domain Peptidase_M13_N PF05649.13 CDW59783.1 - 3.3e-86 290.4 1.8 5.2e-86 289.7 1.8 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CDW59783.1 - 1.5e-68 230.4 1.0 1.5e-68 230.4 1.0 2.0 3 0 0 3 3 3 1 Peptidase family M13 Flexi_CP_N PF08358.10 CDW59783.1 - 0.13 12.3 0.0 0.34 10.9 0.0 1.7 1 0 0 1 1 1 0 Carlavirus coat HSL_N PF06350.12 CDW59784.1 - 2.7e-45 154.7 0.3 3.8e-45 154.2 0.3 1.1 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Abhydrolase_3 PF07859.13 CDW59784.1 - 1.4e-36 126.4 0.0 2e-24 86.6 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CDW59784.1 - 3.5e-06 26.1 0.0 5.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Sec63 PF02889.16 CDW59786.1 - 1.2e-19 70.5 0.9 1.1e-11 44.4 0.2 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.31 CDW59786.1 - 5.7e-17 61.6 0.1 1.4e-16 60.3 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain Pkinase PF00069.25 CDW59787.1 - 2.6e-52 177.8 0.0 3.3e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59787.1 - 1.7e-30 106.2 0.0 2.5e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW59787.1 - 2.5e-06 27.0 0.0 3.6e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CDW59787.1 - 0.014 14.2 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Fer4_22 PF17179.4 CDW59787.1 - 0.088 13.7 1.6 0.19 12.6 1.6 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain SH2 PF00017.24 CDW59788.1 - 4.9e-17 61.8 0.1 0.0015 18.6 0.0 4.7 4 0 0 4 4 4 4 SH2 domain Auto_anti-p27 PF06677.12 CDW59789.1 - 3.3e-11 43.2 7.1 5.4e-11 42.5 7.1 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF4769 PF15992.5 CDW59789.1 - 0.02 14.7 0.1 0.024 14.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) RGS-like PF09128.11 CDW59789.1 - 0.093 12.4 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain zf-RRN7 PF11781.8 CDW59789.1 - 0.37 10.5 8.2 0.64 9.8 8.2 1.2 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Pkinase PF00069.25 CDW59790.1 - 2.6e-15 56.5 0.0 3e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59790.1 - 2.2e-06 27.1 0.0 2.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW59790.1 - 0.00041 19.2 0.0 0.00062 18.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDW59790.1 - 0.0075 15.6 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW59790.1 - 0.0083 16.1 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Vps16_N PF04841.13 CDW59791.1 - 2.6e-25 89.0 0.0 4e-23 81.9 0.0 2.0 1 1 0 2 2 2 2 Vps16, N-terminal region Vps16_C PF04840.12 CDW59792.1 - 6.6e-35 120.7 6.3 1.1e-34 120.0 6.3 1.3 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 CDW59792.1 - 1.3e-34 119.6 0.1 5.5e-34 117.6 0.1 1.9 1 1 0 1 1 1 1 Vps16, N-terminal region Filament PF00038.21 CDW59793.1 - 2.4e-55 188.3 40.2 4.4e-55 187.5 40.2 1.4 1 0 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 CDW59793.1 - 1.1e-10 41.8 0.0 2.6e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Lamin Tail Domain APG6_N PF17675.1 CDW59793.1 - 0.0016 18.9 41.2 0.42 11.2 5.6 4.4 2 2 2 4 4 4 3 Apg6 coiled-coil region DUF2353 PF09789.9 CDW59793.1 - 0.0027 17.1 18.6 0.0027 17.1 18.6 3.7 1 1 3 4 4 4 1 Uncharacterized coiled-coil protein (DUF2353) Prefoldin_2 PF01920.20 CDW59793.1 - 0.0069 16.3 20.4 0.13 12.2 4.1 5.0 2 2 1 4 4 4 1 Prefoldin subunit Spc7 PF08317.11 CDW59793.1 - 0.007 15.3 36.5 0.031 13.1 7.2 3.4 1 1 3 4 4 4 3 Spc7 kinetochore protein Myosin_tail_1 PF01576.19 CDW59793.1 - 0.013 13.4 44.3 0.029 12.2 43.4 1.7 1 1 1 2 2 2 0 Myosin tail GhoS PF11080.8 CDW59793.1 - 0.033 14.1 0.3 0.3 11.1 0.0 2.7 3 1 0 3 3 2 0 Endoribonuclease GhoS Prominin PF05478.11 CDW59793.1 - 0.055 11.4 21.8 0.2 9.6 11.3 2.7 1 1 2 3 3 3 0 Prominin DHR10 PF18595.1 CDW59793.1 - 0.072 13.2 41.4 0.078 13.0 3.5 4.8 2 2 0 4 4 4 0 Designed helical repeat protein 10 domain CENP-F_leu_zip PF10473.9 CDW59793.1 - 0.076 13.0 35.0 0.45 10.5 1.4 4.7 2 2 3 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.12 CDW59793.1 - 0.092 12.8 18.3 0.51 10.3 1.0 4.1 3 1 1 4 4 4 0 Laminin Domain II UPF0242 PF06785.11 CDW59793.1 - 0.15 12.1 35.1 0.082 13.0 6.0 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 CDW59793.1 - 0.18 11.9 40.2 0.51 10.4 0.5 5.3 2 1 4 6 6 6 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 CDW59793.1 - 0.25 10.7 39.4 0.028 13.8 4.8 4.1 2 2 1 3 3 3 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 CDW59793.1 - 0.28 11.9 28.7 7.5 7.3 3.1 5.1 1 1 3 5 5 5 0 Initiation control protein YabA DUF4156 PF13698.6 CDW59793.1 - 0.47 10.8 2.1 1.2 9.5 0.4 2.6 2 1 1 3 3 1 0 Domain of unknown function (DUF4156) Golgin_A5 PF09787.9 CDW59793.1 - 0.89 9.0 42.5 0.067 12.7 15.3 3.6 1 1 1 3 3 3 0 Golgin subfamily A member 5 ATPase_2 PF01637.18 CDW59793.1 - 0.92 9.4 7.8 0.83 9.5 0.5 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATG16 PF08614.11 CDW59793.1 - 0.97 9.6 38.1 0.18 12.0 8.9 3.5 2 2 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 CDW59793.1 - 1 9.4 21.8 0.08 13.0 0.9 4.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 CDW59793.1 - 1 9.4 6.6 17 5.5 0.6 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus bZIP_1 PF00170.21 CDW59793.1 - 1.9 8.7 19.6 0.88 9.7 2.1 5.0 4 1 0 4 4 4 0 bZIP transcription factor DUF745 PF05335.13 CDW59793.1 - 1.9 8.2 19.5 0.11 12.2 0.8 3.6 2 2 2 4 4 4 0 Protein of unknown function (DUF745) FlaC_arch PF05377.11 CDW59793.1 - 2 8.9 13.9 9 6.8 0.6 5.3 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) Bacillus_HBL PF05791.11 CDW59793.1 - 2 8.2 16.6 0.45 10.3 0.8 3.4 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Lebercilin PF15619.6 CDW59793.1 - 2.3 7.8 42.2 0.78 9.4 16.7 3.6 1 1 3 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF2730 PF10805.8 CDW59793.1 - 2.7 8.1 13.5 2.1 8.5 0.9 4.4 2 2 3 5 5 4 0 Protein of unknown function (DUF2730) TSC22 PF01166.18 CDW59793.1 - 2.7 8.4 19.3 1.4 9.2 1.5 5.4 5 0 0 5 5 5 0 TSC-22/dip/bun family DUF4140 PF13600.6 CDW59793.1 - 3 8.3 21.9 34 4.9 0.9 5.5 3 2 2 5 5 5 0 N-terminal domain of unknown function (DUF4140) BLOC1_2 PF10046.9 CDW59793.1 - 3.1 8.2 25.7 3.2 8.1 5.3 5.2 3 2 2 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lectin_N PF03954.14 CDW59793.1 - 4.3 7.1 10.8 3.2 7.5 0.1 3.8 3 1 0 3 3 3 0 Hepatic lectin, N-terminal domain TMF_DNA_bd PF12329.8 CDW59793.1 - 5 7.2 29.7 1.8 8.6 2.1 5.9 3 2 3 6 6 5 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 CDW59793.1 - 6.4 7.5 36.3 5.5 7.7 0.2 6.8 3 2 3 6 6 6 0 SlyX GrpE PF01025.19 CDW59793.1 - 6.7 6.4 29.1 1.4 8.5 0.3 4.7 1 1 2 4 4 4 0 GrpE DUF948 PF06103.11 CDW59793.1 - 7 7.0 7.2 1e+02 3.3 0.2 4.4 2 2 3 5 5 5 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 CDW59793.1 - 8.2 6.6 31.1 0.089 13.0 4.2 4.4 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family Nas2_N PF18265.1 CDW59793.1 - 9.9 6.2 11.1 20 5.2 1.4 4.4 2 2 2 4 4 4 0 Nas2 N_terminal domain DNA_pol3_finger PF17657.1 CDW59794.1 - 5.5e-63 211.2 0.1 8.9e-63 210.6 0.1 1.4 1 0 0 1 1 1 1 Bacterial DNA polymerase III alpha subunit finger domain ACCA PF03255.14 CDW59794.1 - 5.8e-60 201.3 0.1 1.4e-59 200.1 0.1 1.7 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit HHH_6 PF14579.6 CDW59794.1 - 6.2e-26 90.5 0.0 1.7e-25 89.1 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif Carboxyl_trans PF01039.22 CDW59794.1 - 4.7e-17 61.8 0.1 8.3e-17 61.0 0.1 1.3 1 0 0 1 1 1 1 Carboxyl transferase domain tRNA_anti-codon PF01336.25 CDW59794.1 - 7.2e-09 35.5 0.1 1.3e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain OKR_DC_1 PF01276.20 CDW59795.1 - 1.1e-195 650.3 0.0 1.3e-195 650.0 0.0 1.1 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain OKR_DC_1_C PF03711.15 CDW59795.1 - 1.7e-46 157.8 0.0 4.3e-46 156.5 0.0 1.7 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, C-terminal domain OKR_DC_1_N PF03709.15 CDW59795.1 - 2.4e-27 95.4 0.0 6.2e-27 94.1 0.0 1.7 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, N-terminal domain DUF1281_C PF18406.1 CDW59795.1 - 0.1 12.3 0.3 7.8 6.3 0.1 2.4 2 0 0 2 2 2 0 Ferredoxin-like domain in Api92-like protein ATP_bind_3 PF01171.20 CDW59796.1 - 6.4e-57 192.3 0.0 1e-56 191.6 0.0 1.3 1 0 0 1 1 1 1 PP-loop family TilS_C PF11734.8 CDW59796.1 - 1.6e-26 91.5 0.0 4.9e-26 90.0 0.0 1.9 2 0 0 2 2 2 1 TilS substrate C-terminal domain Glyoxalase PF00903.25 CDW59796.1 - 2.3e-21 76.3 0.0 3.6e-21 75.7 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TilS PF09179.11 CDW59796.1 - 7.6e-20 71.2 5.3 3.5e-19 69.1 5.3 2.3 1 0 0 1 1 1 1 TilS substrate binding domain Glyoxalase_4 PF13669.6 CDW59796.1 - 2.5e-11 43.8 0.0 1.4e-10 41.4 0.0 2.2 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CDW59796.1 - 3.8e-06 27.1 0.1 9.2e-06 25.9 0.1 1.7 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CDW59796.1 - 0.0008 20.2 0.0 0.0036 18.1 0.0 2.2 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CDW59796.1 - 0.0046 16.9 0.0 0.0089 15.9 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain ROF PF07073.12 CDW59797.1 - 2e-28 98.3 0.1 2.3e-28 98.2 0.1 1.0 1 0 0 1 1 1 1 Modulator of Rho-dependent transcription termination (ROF) YaeQ PF07152.12 CDW59798.1 - 1.4e-71 239.6 1.2 1.6e-71 239.4 1.2 1.0 1 0 0 1 1 1 1 YaeQ protein NlpE_C PF17185.4 CDW59799.1 - 9.9e-32 109.1 0.1 4.4e-31 107.0 0.0 2.0 2 1 0 2 2 2 1 NlpE C-terminal OB domain NlpE PF04170.12 CDW59799.1 - 4e-27 95.0 0.0 1.5e-26 93.1 0.0 1.9 2 1 0 2 2 2 1 NlpE N-terminal domain Peptidase_C92 PF05708.12 CDW59800.1 - 2.6e-12 47.2 0.0 4.2e-09 36.7 0.0 2.2 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family NLPC_P60 PF00877.19 CDW59800.1 - 5.2e-06 26.4 0.0 0.0007 19.6 0.0 2.6 2 1 0 2 2 2 2 NlpC/P60 family tRNA-synt_2b PF00587.25 CDW59801.1 - 5.1e-49 166.7 0.0 7.2e-49 166.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 CDW59801.1 - 8.1e-27 93.7 0.1 1.6e-26 92.8 0.1 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.20 CDW59801.1 - 1.9e-21 76.0 0.1 4.1e-21 74.9 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain TIR_2 PF13676.6 CDW59801.1 - 0.12 13.0 0.0 0.35 11.5 0.0 1.8 1 0 0 1 1 1 0 TIR domain Lipoprotein_9 PF03180.14 CDW59802.1 - 1.3e-99 332.1 3.1 1.8e-99 331.6 3.1 1.2 1 0 0 1 1 1 1 NLPA lipoprotein TrmO PF01980.16 CDW59802.1 - 3.8e-45 153.0 0.0 8.5e-45 151.8 0.0 1.6 1 0 0 1 1 1 1 tRNA-methyltransferase O RcsF PF16358.5 CDW59802.1 - 1.3e-42 144.3 0.1 2.8e-42 143.2 0.1 1.5 1 0 0 1 1 1 1 RcsF lipoprotein TrmO_C PF18389.1 CDW59802.1 - 3.6e-23 81.5 0.1 7.2e-23 80.5 0.1 1.5 1 0 0 1 1 1 1 TrmO C-terminal domain OpuAC PF04069.12 CDW59802.1 - 0.00044 19.9 0.6 0.00066 19.3 0.6 1.4 1 1 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system Phosphonate-bd PF12974.7 CDW59802.1 - 0.022 14.3 0.1 0.058 13.0 0.0 1.6 2 0 0 2 2 2 0 ABC transporter, phosphonate, periplasmic substrate-binding protein BPD_transp_1 PF00528.22 CDW59803.1 - 2.4e-21 76.3 17.7 2.9e-21 76.0 17.7 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component ABC_tran PF00005.27 CDW59804.1 - 3.8e-37 127.9 0.0 6.1e-37 127.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter NIL PF09383.10 CDW59804.1 - 1.6e-20 72.7 0.0 3.1e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 NIL domain AAA_21 PF13304.6 CDW59804.1 - 1.6e-09 38.0 0.5 9.9e-05 22.3 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW59804.1 - 2.9e-06 26.9 0.1 1.6e-05 24.4 0.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDW59804.1 - 1.4e-05 25.4 0.4 9.4e-05 22.7 0.4 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW59804.1 - 0.00057 20.3 0.3 0.002 18.6 0.3 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDW59804.1 - 0.0055 16.4 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CDW59804.1 - 0.0077 15.8 0.1 2.9 7.4 0.0 2.8 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 CDW59804.1 - 0.012 15.6 0.1 0.021 14.7 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 CDW59804.1 - 0.021 15.0 0.2 0.2 11.9 0.2 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit TniB PF05621.11 CDW59804.1 - 0.034 13.5 0.0 0.66 9.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein ABC_ATPase PF09818.9 CDW59804.1 - 0.075 11.8 0.0 4 6.1 0.0 2.3 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_33 PF13671.6 CDW59804.1 - 0.096 12.8 0.1 0.26 11.5 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CDW59804.1 - 0.14 12.6 0.1 0.27 11.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CDW59804.1 - 0.15 12.2 0.0 0.45 10.6 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase Hydrolase_like PF13242.6 CDW59805.1 - 3e-13 49.6 0.1 5.3e-13 48.8 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 CDW59805.1 - 8.9e-08 32.4 0.1 3.3e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW59805.1 - 6.9e-06 26.5 0.0 1.6e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PNK3P PF08645.11 CDW59805.1 - 1.5e-05 24.7 0.0 3.7e-05 23.5 0.0 1.5 1 1 1 2 2 2 1 Polynucleotide kinase 3 phosphatase Patched PF02460.18 CDW59806.1 - 6.6e-33 113.8 4.3 7.4e-32 110.4 4.3 1.9 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CDW59806.1 - 2.9e-12 46.7 2.6 2.9e-12 46.7 2.6 1.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation DUF4231 PF14015.6 CDW59806.1 - 0.19 12.2 2.0 0.41 11.1 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) CysG_dimeriser PF10414.9 CDW59808.1 - 0.22 11.3 1.1 3.7 7.3 0.2 2.4 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region Tcp10_C PF07202.13 CDW59809.1 - 7.3e-46 156.3 0.1 7.3e-46 156.3 0.1 1.6 2 0 0 2 2 2 1 T-complex protein 10 C-terminus Fez1 PF06818.15 CDW59809.1 - 0.00012 22.6 7.9 0.00012 22.6 7.9 2.6 1 1 1 2 2 2 1 Fez1 Pox_A_type_inc PF04508.12 CDW59809.1 - 0.0002 21.1 1.6 0.002 17.9 0.5 2.6 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat DUF4407 PF14362.6 CDW59809.1 - 0.012 15.0 6.7 0.021 14.2 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 CDW59809.1 - 0.03 13.2 24.9 0.008 15.1 21.6 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein YabA PF06156.13 CDW59809.1 - 0.033 14.8 0.1 0.033 14.8 0.1 2.9 2 1 0 2 2 2 0 Initiation control protein YabA TSC22 PF01166.18 CDW59809.1 - 0.041 14.2 10.4 0.28 11.5 0.0 3.5 2 1 1 3 3 3 0 TSC-22/dip/bun family ATG16 PF08614.11 CDW59809.1 - 0.048 13.9 22.9 0.14 12.3 22.9 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CASP_C PF08172.12 CDW59809.1 - 0.068 12.5 10.9 0.15 11.3 10.9 1.6 1 0 0 1 1 1 0 CASP C terminal RHS_repeat PF05593.14 CDW59809.1 - 0.16 12.6 1.4 2.7 8.6 0.4 2.9 3 0 0 3 3 3 0 RHS Repeat TMF_TATA_bd PF12325.8 CDW59809.1 - 0.19 11.9 22.7 0.088 13.0 0.9 2.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ADIP PF11559.8 CDW59809.1 - 0.33 11.0 24.4 0.11 12.6 7.7 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ERM PF00769.19 CDW59809.1 - 0.49 10.2 27.7 1.4 8.7 0.9 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF724 PF05266.14 CDW59809.1 - 0.56 10.0 17.6 0.53 10.1 16.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Prominin PF05478.11 CDW59809.1 - 0.79 7.6 8.0 1.4 6.8 8.0 1.3 1 0 0 1 1 1 0 Prominin NPV_P10 PF05531.12 CDW59809.1 - 0.87 10.1 6.0 8.5 6.9 1.0 3.2 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein IL6 PF00489.17 CDW59809.1 - 0.88 9.1 7.6 0.4 10.2 1.5 2.3 1 1 1 2 2 2 0 Interleukin-6/G-CSF/MGF family Golgin_A5 PF09787.9 CDW59809.1 - 1.2 8.5 17.5 2.7 7.4 17.5 1.5 1 0 0 1 1 1 0 Golgin subfamily A member 5 Herpes_UL6 PF01763.16 CDW59809.1 - 1.7 7.1 10.0 2.5 6.5 8.5 1.8 1 1 1 2 2 2 0 Herpesvirus UL6 like Fib_alpha PF08702.10 CDW59809.1 - 2.5 8.3 10.8 5.2 7.2 8.2 2.3 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 CDW59809.1 - 9.9 5.6 15.1 24 4.3 15.1 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 CDW59809.1 - 10 6.7 27.9 4.2 7.9 7.9 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region Glyco_trans_2_3 PF13632.6 CDW59810.1 - 1.3e-09 38.2 1.2 1.6e-09 37.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family group 2 DUF4381 PF14316.6 CDW59810.1 - 0.098 12.9 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Histone PF00125.24 CDW59812.1 - 5.8e-34 117.3 3.7 5.8e-34 117.3 3.7 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 BRCT_assoc PF12820.7 CDW59812.1 - 2.5e-05 24.2 8.3 0.024 14.5 0.5 2.2 1 1 1 2 2 2 2 Serine-rich domain associated with BRCT CENP-T_C PF15511.6 CDW59812.1 - 4.4e-05 23.6 0.1 0.0001 22.4 0.1 1.7 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW59812.1 - 0.016 15.6 0.1 0.031 14.6 0.1 1.6 1 0 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW59812.1 - 0.056 13.7 0.9 0.15 12.3 0.0 2.2 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Ctr PF04145.15 CDW59812.1 - 1.4 9.5 6.9 0.49 11.0 0.7 2.1 1 1 1 2 2 2 0 Ctr copper transporter family SOBP PF15279.6 CDW59812.1 - 1.9 9.0 5.2 2.3 8.8 5.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein BBP1_C PF15272.6 CDW59812.1 - 4 7.2 7.4 12 5.7 0.2 2.2 2 0 0 2 2 2 0 Spindle pole body component BBP1, C-terminal Histone PF00125.24 CDW59813.1 - 2.3e-34 118.6 3.5 2.3e-34 118.6 3.5 1.7 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW59813.1 - 9.9e-05 22.4 0.1 0.00017 21.6 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold BRCT_assoc PF12820.7 CDW59813.1 - 0.0096 15.8 1.5 0.014 15.2 1.5 1.2 1 0 0 1 1 1 1 Serine-rich domain associated with BRCT CENP-S PF15630.6 CDW59813.1 - 0.03 14.7 0.0 0.054 13.9 0.0 1.5 1 0 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW59813.1 - 0.046 14.0 0.1 0.088 13.1 0.1 1.5 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW59813.1 - 0.12 12.6 0.2 0.22 11.7 0.2 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) PI3Ka PF00613.20 CDW59814.1 - 8.5e-50 168.7 1.1 2.6e-49 167.2 0.1 2.0 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 CDW59814.1 - 1.5e-45 156.0 0.0 2.4e-31 109.5 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 CDW59814.1 - 3.1e-31 108.2 0.0 5.5e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 CDW59814.1 - 0.023 14.1 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) EGF PF00008.27 CDW59815.1 - 4.2e-21 74.9 54.2 4.2e-07 30.1 8.9 4.6 4 1 0 4 4 4 4 EGF-like domain hEGF PF12661.7 CDW59815.1 - 8.4e-14 51.6 53.4 0.00015 22.3 8.1 5.3 5 0 0 5 5 5 4 Human growth factor-like EGF EGF_2 PF07974.13 CDW59815.1 - 4.3e-11 43.0 56.4 0.0039 17.5 9.8 4.3 4 0 0 4 4 4 4 EGF-like domain EGF_CA PF07645.15 CDW59815.1 - 1.5e-09 37.9 50.9 7.2e-06 26.1 9.0 4.3 4 0 0 4 4 4 4 Calcium-binding EGF domain EGF_3 PF12947.7 CDW59815.1 - 0.0029 17.8 6.7 0.0029 17.8 6.7 4.8 3 2 0 4 4 4 3 EGF domain FXa_inhibition PF14670.6 CDW59815.1 - 0.015 15.6 48.8 0.062 13.6 8.4 4.6 4 0 0 4 4 4 0 Coagulation Factor Xa inhibitory site Laminin_EGF PF00053.24 CDW59815.1 - 0.017 15.3 43.4 0.51 10.5 6.2 4.4 1 1 3 4 4 4 0 Laminin EGF domain MtN3_slv PF03083.16 CDW59816.1 - 9.7e-25 86.4 13.3 1.1e-10 41.4 1.3 3.6 2 1 1 3 3 3 3 Sugar efflux transporter for intercellular exchange CAP PF00188.26 CDW59817.1 - 4.5e-18 66.3 3.0 1.4e-17 64.7 3.0 1.7 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Retrotran_gag_2 PF14223.6 CDW59818.1 - 3.7e-17 62.3 0.1 8.9e-09 35.1 0.1 2.2 1 1 1 2 2 2 2 gag-polypeptide of LTR copia-type DUF3498 PF12004.8 CDW59818.1 - 0.09 12.0 0.4 0.096 11.9 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) His_Phos_1 PF00300.22 CDW59819.1 - 2e-12 47.2 0.0 4.5e-12 46.1 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lyase_catalyt PF09093.11 CDW59819.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Lyase, catalytic Arf PF00025.21 CDW59820.1 - 3.4e-79 264.3 0.2 4e-79 264.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CDW59820.1 - 8.9e-15 55.0 0.0 1.3e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CDW59820.1 - 2.8e-14 52.9 0.0 3.5e-14 52.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CDW59820.1 - 1.3e-13 50.8 1.1 1.3e-09 37.7 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CDW59820.1 - 5.8e-13 48.8 0.0 6.6e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CDW59820.1 - 1.9e-11 43.8 0.0 2.3e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW59820.1 - 1.4e-06 28.4 0.1 3.6e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CDW59820.1 - 0.0022 17.4 0.3 0.015 14.6 0.1 1.9 2 0 0 2 2 2 1 6-phosphofructo-2-kinase CRISPR_Cas2 PF09827.9 CDW59820.1 - 0.021 15.0 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 CRISPR associated protein Cas2 Methyltrn_RNA_3 PF02598.17 CDW59820.1 - 0.073 12.6 0.0 0.091 12.2 0.0 1.1 1 0 0 1 1 1 0 Putative RNA methyltransferase ABC_tran PF00005.27 CDW59820.1 - 0.2 12.2 1.3 2 9.0 1.3 2.0 1 1 0 1 1 1 0 ABC transporter CBFD_NFYB_HMF PF00808.23 CDW59821.1 - 1.7e-23 82.6 0.1 2.9e-23 81.9 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDW59821.1 - 8.6e-05 22.9 0.0 0.00011 22.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PDE8 PF08629.10 CDW59821.1 - 0.0031 17.5 0.7 0.0059 16.6 0.7 1.4 1 0 0 1 1 1 1 PDE8 phosphodiesterase CENP-X PF09415.10 CDW59821.1 - 0.024 15.0 0.2 0.046 14.0 0.2 1.7 1 1 0 1 1 1 0 CENP-S associating Centromere protein X IF-2B PF01008.17 CDW59822.1 - 1.5e-59 201.5 0.1 2.3e-59 200.9 0.1 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF3822 PF12864.7 CDW59822.1 - 0.11 11.7 0.0 2 7.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3822) Tubulin PF00091.25 CDW59823.1 - 1.1e-32 113.9 0.0 1.4e-32 113.5 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 CDW59823.1 - 2.9e-05 24.3 0.0 0.036 14.4 0.0 2.3 2 0 0 2 2 2 2 Misato Segment II tubulin-like domain MFS_1 PF07690.16 CDW59824.1 - 1.5e-22 80.0 42.8 1.1e-13 50.9 19.1 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_4 PF06779.14 CDW59824.1 - 4.2e-07 29.6 15.0 4.2e-07 29.6 15.0 2.5 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB XendoU PF09412.10 CDW59826.1 - 2.4e-75 253.2 0.1 3e-75 252.9 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease XendoU U3_assoc_6 PF08640.11 CDW59826.1 - 0.029 14.4 0.3 0.065 13.3 0.3 1.6 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 6 EndoU_bacteria PF14436.6 CDW59826.1 - 0.084 13.2 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial EndoU nuclease EF-hand_7 PF13499.6 CDW59826.1 - 0.42 11.1 2.4 2.2 8.8 0.0 2.9 2 2 0 2 2 2 0 EF-hand domain pair cwf21 PF08312.12 CDW59826.1 - 0.43 10.8 0.1 0.43 10.8 0.1 1.9 2 0 0 2 2 2 0 cwf21 domain zf-C2H2 PF00096.26 CDW59827.1 - 2.8e-31 106.2 91.5 6.8e-05 23.1 0.3 14.2 14 0 0 14 14 14 10 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW59827.1 - 9.1e-30 100.8 91.5 0.0074 17.0 1.2 14.3 14 0 0 14 14 14 12 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW59827.1 - 2.5e-25 87.7 87.9 1.3e-05 25.4 0.4 14.4 14 1 0 14 14 14 8 Zinc-finger double domain zf-met PF12874.7 CDW59827.1 - 5.7e-09 36.1 64.5 0.004 17.5 0.6 13.1 13 1 0 13 13 13 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW59827.1 - 5.6e-08 32.9 64.6 0.34 11.2 0.0 12.8 14 0 0 14 14 14 7 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CDW59827.1 - 3.7e-06 26.8 56.4 0.00077 19.4 0.5 11.2 12 0 0 12 12 12 3 C2H2-type zinc finger ADK_lid PF05191.14 CDW59827.1 - 3.1e-05 23.9 17.2 0.38 10.8 0.1 6.9 5 3 1 6 6 6 2 Adenylate kinase, active site lid zf_UBZ PF18439.1 CDW59827.1 - 0.026 14.1 31.2 11 5.7 0.0 10.0 10 0 0 10 10 10 0 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 CDW59827.1 - 0.037 14.1 0.3 0.037 14.1 0.3 10.2 7 3 3 10 10 10 0 Zinc ribbon domain zf-MYST PF17772.1 CDW59827.1 - 0.4 10.3 0.0 0.4 10.3 0.0 6.4 9 1 1 10 10 9 0 MYST family zinc finger domain zf-C2H2_12 PF18658.1 CDW59827.1 - 0.44 10.1 6.4 0.84 9.3 0.0 4.5 6 1 1 7 7 7 0 Zinc-finger C2H2-type zf-Di19 PF05605.12 CDW59827.1 - 0.81 10.0 54.9 0.9 9.9 3.1 8.8 5 1 2 8 8 8 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_15 PF17032.5 CDW59827.1 - 3.8 8.3 32.5 9.3 7.1 0.8 7.5 2 1 7 9 9 9 0 zinc-ribbon family THAP PF05485.12 CDW59829.1 - 2.5e-09 37.9 0.0 6.9e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 THAP domain Slx4 PF09494.10 CDW59831.1 - 2.6e-11 43.3 0.0 6.3e-11 42.1 0.0 1.7 1 0 0 1 1 1 1 Slx4 endonuclease Glutaminase PF04960.15 CDW59832.1 - 1.3e-40 139.4 0.0 1.5e-40 139.2 0.0 1.0 1 0 0 1 1 1 1 Glutaminase E1-E2_ATPase PF00122.20 CDW59833.1 - 5.1e-51 172.7 0.7 5.1e-51 172.7 0.7 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CDW59833.1 - 4.3e-50 170.9 9.2 6.1e-50 170.4 6.4 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CDW59833.1 - 5.7e-29 100.4 0.3 1.5e-14 54.2 0.0 2.7 2 0 0 2 2 2 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CDW59833.1 - 1.1e-08 35.1 0.9 1.1e-05 25.3 0.7 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CDW59833.1 - 4.1e-05 24.1 0.5 0.0004 20.9 0.1 2.8 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDW59833.1 - 0.017 15.2 0.1 0.095 12.8 0.0 2.1 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase T2SSF PF00482.23 CDW59833.1 - 0.048 13.6 5.8 3.7 7.5 0.3 3.8 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F CstA_5TM PF13722.6 CDW59833.1 - 0.056 13.8 0.4 0.056 13.8 0.4 3.5 3 1 0 3 3 3 0 5TM C-terminal transporter carbon starvation CstA DNA_photolyase PF00875.18 CDW59833.1 - 0.085 12.9 1.4 0.67 9.9 0.0 2.4 2 0 0 2 2 2 0 DNA photolyase DUF2207 PF09972.9 CDW59833.1 - 0.088 11.6 0.0 7 5.3 0.0 2.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) tRNA_edit PF04073.15 CDW59834.1 - 4e-23 81.8 0.2 5e-23 81.5 0.2 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain 5_nucleotid_C PF02872.18 CDW59835.1 - 6e-33 114.3 0.3 1.4e-32 113.1 0.3 1.6 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CDW59835.1 - 9.9e-18 65.4 0.1 1.5e-17 64.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MFS_1 PF07690.16 CDW59836.1 - 3.7e-38 131.3 56.9 1e-24 87.1 23.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CDW59836.1 - 0.00026 19.5 15.8 0.012 14.0 4.6 2.5 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Tad PF13400.6 CDW59836.1 - 0.26 11.6 0.2 0.26 11.6 0.2 5.8 7 1 0 7 7 7 0 Putative Flp pilus-assembly TadE/G-like Na_H_Exchanger PF00999.21 CDW59837.1 - 5.5e-77 259.1 54.2 7.6e-77 258.7 54.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TrkA_N PF02254.18 CDW59837.1 - 2.3e-25 89.1 0.3 3.9e-25 88.4 0.3 1.4 1 0 0 1 1 1 1 TrkA-N domain ApbA PF02558.16 CDW59837.1 - 0.016 14.9 0.0 0.034 13.8 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA B12-binding_2 PF02607.17 CDW59837.1 - 0.035 14.6 0.0 0.12 12.8 0.0 1.9 1 0 0 1 1 1 0 B12 binding domain PfkB PF00294.24 CDW59838.1 - 7.1e-13 48.5 0.0 4.6e-09 36.0 0.0 2.4 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Abhydrolase_3 PF07859.13 CDW59839.1 - 3.9e-53 180.5 0.0 5.4e-53 180.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CDW59839.1 - 1.8e-07 30.4 0.0 2.5e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase DLH PF01738.18 CDW59839.1 - 0.0003 20.4 0.1 0.00067 19.3 0.0 1.6 2 0 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CDW59839.1 - 0.004 16.6 0.0 0.0077 15.7 0.0 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 CDW59839.1 - 0.015 15.2 0.0 0.19 11.5 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Ferrochelatase PF00762.19 CDW59840.1 - 5.1e-99 331.3 0.0 6.2e-99 331.1 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 CDW59840.1 - 3.4e-05 24.1 0.0 0.0018 18.5 0.0 2.5 2 0 0 2 2 2 1 CbiX HTH_AsnC-type PF13404.6 CDW59840.1 - 0.052 13.4 0.0 0.7 9.8 0.0 2.7 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain Lipase_GDSL_3 PF14606.6 CDW59840.1 - 0.22 11.7 0.0 0.34 11.0 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family ADK PF00406.22 CDW59841.1 - 6.2e-61 204.9 0.0 7.5e-61 204.7 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CDW59841.1 - 6.7e-28 97.8 0.3 1.4e-27 96.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 CDW59841.1 - 8.4e-17 60.9 0.0 1.4e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 CDW59841.1 - 1e-05 25.9 0.5 0.072 13.4 0.0 2.4 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 CDW59841.1 - 0.00092 19.4 0.0 0.0048 17.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDW59841.1 - 0.0039 17.7 0.0 0.0081 16.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDW59841.1 - 0.03 14.6 0.0 0.049 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 CDW59841.1 - 0.14 11.8 0.3 0.72 9.5 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase HSP90 PF00183.18 CDW59842.1 - 2.9e-128 429.0 7.4 4.7e-126 421.7 6.9 2.0 1 1 1 2 2 2 2 Hsp90 protein Apolipoprotein PF01442.18 CDW59842.1 - 0.0017 18.3 1.5 0.0078 16.1 0.1 2.2 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain HP0268 PF18618.1 CDW59842.1 - 0.031 14.7 0.0 0.14 12.6 0.0 2.2 1 0 0 1 1 1 0 HP0268 PE PF00934.20 CDW59842.1 - 0.21 11.9 2.1 0.37 11.2 0.2 2.3 2 1 0 2 2 2 0 PE family TruB_N PF01509.18 CDW59844.1 - 0.061 13.7 0.0 0.085 13.2 0.0 1.2 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Rod_C PF10493.9 CDW59844.1 - 0.068 11.5 0.0 0.078 11.4 0.0 1.0 1 0 0 1 1 1 0 Rough deal protein C-terminal region zf-H2C2_2 PF13465.6 CDW59845.1 - 0.058 13.9 0.6 0.058 13.9 0.6 7.0 9 0 0 9 9 9 0 Zinc-finger double domain zf-C2H2_12 PF18658.1 CDW59845.1 - 1.1 8.9 9.3 1.7 8.3 1.3 3.7 4 0 0 4 4 4 0 Zinc-finger C2H2-type Actin_micro PF17003.5 CDW59845.1 - 6.8 5.8 8.7 1.4 8.0 1.6 2.5 2 1 0 2 2 2 0 Putative actin-like family Arm-DNA-bind_3 PF13356.6 CDW59846.1 - 0.045 14.1 0.0 0.071 13.5 0.0 1.3 1 0 0 1 1 1 0 Arm DNA-binding domain Histone_H2A_C PF16211.5 CDW59847.1 - 3.8e-19 68.1 0.4 7.6e-19 67.1 0.4 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW59847.1 - 4.7e-16 59.3 0.0 6e-16 59.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59847.1 - 7.8e-05 22.9 0.0 0.00011 22.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDW59848.1 - 1.4e-20 74.0 0.1 1.7e-20 73.7 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW59848.1 - 1.1e-05 25.6 0.0 2.5e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW59848.1 - 0.0062 16.6 0.1 0.0068 16.4 0.1 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 CDW59848.1 - 0.012 16.1 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 CDW59849.1 - 2.2e-51 173.7 3.9 2.4e-51 173.5 3.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW59849.1 - 0.00016 22.3 2.2 0.00021 21.9 2.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW59849.1 - 0.00016 21.7 1.0 0.00025 21.1 0.1 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW59849.1 - 0.0017 18.7 0.1 0.0028 18.0 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW59849.1 - 0.02 14.9 0.1 0.049 13.7 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW59849.1 - 0.035 14.4 0.1 0.072 13.4 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone KMP11 PF03037.16 CDW59850.1 - 0.25 12.2 1.8 8 7.3 0.1 2.3 1 1 1 2 2 2 0 Kinetoplastid membrane protein 11 TehB PF03848.14 CDW59851.1 - 3.1e-98 326.9 0.1 4.3e-98 326.4 0.1 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB SLAC1 PF03595.17 CDW59851.1 - 1.2e-36 126.6 27.0 1.5e-36 126.3 27.0 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel Methyltransf_25 PF13649.6 CDW59851.1 - 5.4e-13 49.5 0.0 1.1e-12 48.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW59851.1 - 5.2e-12 46.2 0.0 2.5e-11 44.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW59851.1 - 5.9e-11 42.5 0.0 9.2e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW59851.1 - 2.2e-10 41.2 0.0 3.6e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW59851.1 - 6.3e-07 29.1 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDW59851.1 - 8.6e-07 28.9 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 CDW59851.1 - 0.0011 18.6 0.0 0.0028 17.3 0.0 1.5 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 CDW59851.1 - 0.01 15.2 0.0 0.015 14.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 CDW59851.1 - 0.043 13.4 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) B_solenoid_ydck PF18836.1 CDW59852.1 - 4.2e-11 42.2 27.7 3.3e-07 29.9 0.7 7.1 9 0 0 9 9 9 4 Beta solenoid repeat from YDCK Bactofilin PF04519.13 CDW59852.1 - 7e-05 23.0 9.7 0.0023 18.2 2.4 3.4 2 1 2 4 4 4 2 Polymer-forming cytoskeletal Hexapep PF00132.24 CDW59852.1 - 0.0011 18.6 15.3 0.22 11.3 0.8 5.7 6 1 1 7 7 7 3 Bacterial transferase hexapeptide (six repeats) MdoG PF04349.12 CDW59853.1 - 4.5e-181 602.9 0.0 5.2e-181 602.7 0.0 1.0 1 0 0 1 1 1 1 Periplasmic glucan biosynthesis protein, MdoG TAT_signal PF10518.9 CDW59853.1 - 0.0036 17.1 0.6 0.0077 16.0 0.6 1.6 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence EpoR_lig-bind PF09067.10 CDW59853.1 - 0.0076 16.4 0.1 0.068 13.4 0.0 2.2 2 0 0 2 2 2 1 Erythropoietin receptor, ligand binding DUF1338 PF07063.13 CDW59854.1 - 7.3e-121 403.3 0.2 8.5e-121 403.1 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) LysR_substrate PF03466.20 CDW59855.1 - 1.5e-32 112.7 0.0 2e-32 112.3 0.0 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDW59855.1 - 2e-19 69.3 2.7 4.3e-19 68.2 2.7 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_20 PF12840.7 CDW59855.1 - 0.073 13.2 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_30 PF13556.6 CDW59855.1 - 0.073 12.9 0.4 0.14 12.0 0.4 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain MCPsignal PF00015.21 CDW59856.1 - 7.7e-59 198.4 35.4 1.2e-57 194.5 21.3 3.2 3 0 0 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain TarH PF02203.15 CDW59856.1 - 3e-29 102.2 3.8 3e-29 102.2 3.8 3.4 5 0 0 5 5 4 1 Tar ligand binding domain homologue HAMP PF00672.25 CDW59856.1 - 1.9e-10 41.0 0.5 1.9e-10 41.0 0.5 3.6 3 1 1 4 4 4 1 HAMP domain Ni_hydr_CYTB PF01292.20 CDW59856.1 - 5.3e-09 35.9 2.2 1.5e-08 34.4 0.7 2.1 2 0 0 2 2 2 1 Prokaryotic cytochrome b561 4HB_MCP_1 PF12729.7 CDW59856.1 - 0.0009 18.8 4.0 0.0009 18.8 4.0 3.7 4 0 0 4 4 4 1 Four helix bundle sensory module for signal transduction Atg14 PF10186.9 CDW59856.1 - 0.0075 15.4 1.0 0.0075 15.4 1.0 3.2 3 0 0 3 3 3 2 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2062 PF09835.9 CDW59856.1 - 0.034 14.0 1.3 0.11 12.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) DUF4200 PF13863.6 CDW59856.1 - 0.1 13.0 4.7 4.7 7.6 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Fib_alpha PF08702.10 CDW59856.1 - 0.45 10.7 16.3 1 9.5 1.3 3.6 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Tup_N PF08581.10 CDW59856.1 - 0.55 10.6 6.7 19 5.6 0.2 3.7 3 0 0 3 3 3 0 Tup N-terminal DUF1664 PF07889.12 CDW59856.1 - 2.3 8.3 13.9 0.71 9.9 2.2 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) COG2 PF06148.11 CDW59856.1 - 3 7.9 12.0 2.7 8.1 0.4 3.9 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0242 PF06785.11 CDW59856.1 - 5.8 7.0 7.7 6.9 6.7 0.2 3.2 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Aldedh PF00171.22 CDW59857.1 - 3.2e-141 471.0 0.9 3.9e-141 470.7 0.9 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CDW59857.1 - 0.011 14.8 0.1 0.024 13.7 0.1 1.4 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 CDW59857.1 - 0.06 12.8 0.0 0.12 11.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) DUF218 PF02698.17 CDW59858.1 - 7e-16 58.4 0.0 9e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 DUF218 domain DUF3418 PF11898.8 CDW59859.1 - 8.7e-43 146.9 0.1 9.3e-43 146.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3418) ParE_toxin PF05016.15 CDW59859.1 - 0.036 14.7 0.3 0.066 13.8 0.2 1.7 1 1 0 1 1 1 0 ParE toxin of type II toxin-antitoxin system, parDE DUF3734 PF12536.8 CDW59859.1 - 0.063 13.6 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Patatin phospholipase ProRS-C_1 PF09180.11 CDW59860.1 - 7.8e-23 80.5 0.6 1.8e-22 79.3 0.6 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 CDW59860.1 - 5e-20 72.2 0.0 9.7e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CDW59860.1 - 7.5e-16 58.1 0.0 1.9e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain WHEP-TRS PF00458.20 CDW59860.1 - 0.066 13.4 0.5 0.23 11.6 0.0 2.3 3 0 0 3 3 3 0 WHEP-TRS domain Piwi PF02171.17 CDW59861.1 - 9.7e-79 264.7 0.1 1.6e-76 257.5 0.1 2.6 1 1 0 1 1 1 1 Piwi domain PAZ PF02170.22 CDW59861.1 - 1.8e-16 60.2 0.0 3.2e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 CDW59861.1 - 1.6e-11 44.9 0.1 3.3e-11 44.0 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 CDW59861.1 - 2e-11 44.0 0.0 5.7e-11 42.6 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 CDW59861.1 - 3.4e-10 39.4 0.0 9.8e-10 38.0 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoMid PF16487.5 CDW59861.1 - 3.4e-07 30.4 0.0 8.1e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Mid domain of argonaute Tmemb_18A PF09771.9 CDW59861.1 - 0.019 15.3 0.1 0.042 14.2 0.1 1.5 1 0 0 1 1 1 0 Transmembrane protein 188 Metallophos PF00149.28 CDW59863.1 - 8.3e-36 124.4 0.0 3.7e-35 122.3 0.0 1.8 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW59863.1 - 6.1e-08 33.0 0.2 1.1e-07 32.1 0.2 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Amdo_NSP PF12475.8 CDW59863.1 - 0.14 12.3 0.4 23 5.2 0.0 2.5 2 0 0 2 2 2 0 Amdovirus non-structural protein GRIM-19 PF06212.12 CDW59864.1 - 4.1e-30 104.4 0.2 5.5e-30 104.0 0.2 1.2 1 0 0 1 1 1 1 GRIM-19 protein Lon_C PF05362.13 CDW59865.1 - 1.3e-70 237.2 0.0 3.2e-70 235.8 0.0 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CDW59865.1 - 1.1e-35 123.4 0.6 2.3e-35 122.3 0.6 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CDW59865.1 - 5.1e-24 85.2 0.0 1.2e-23 84.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW59865.1 - 5.8e-08 32.8 0.0 1.2e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDW59865.1 - 1.3e-06 28.6 0.0 4.6e-06 26.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) ChlI PF13541.6 CDW59865.1 - 7.8e-06 25.7 0.0 1.7e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.11 CDW59865.1 - 9.1e-06 24.8 0.0 1.7e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 CDW59865.1 - 1.2e-05 25.1 0.0 0.00018 21.3 0.0 2.4 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDW59865.1 - 8.1e-05 23.1 1.6 0.00075 19.9 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CDW59865.1 - 0.0012 19.1 0.6 0.045 14.0 0.0 2.9 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CDW59865.1 - 0.0018 18.2 0.0 0.0053 16.7 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase IstB_IS21 PF01695.17 CDW59865.1 - 0.0027 17.5 0.0 0.0062 16.3 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 CDW59865.1 - 0.0048 16.9 0.0 0.033 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CDW59865.1 - 0.0052 16.7 1.8 0.72 9.7 0.0 2.9 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CDW59865.1 - 0.0054 17.1 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 CDW59865.1 - 0.0058 15.8 0.5 0.014 14.6 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.6 CDW59865.1 - 0.015 15.9 1.4 0.045 14.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_23 PF13476.6 CDW59865.1 - 0.02 15.4 5.0 0.63 10.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CDW59865.1 - 0.03 14.1 0.0 0.076 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 CDW59865.1 - 0.038 13.2 0.0 0.091 11.9 0.0 1.6 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 CDW59865.1 - 0.094 12.6 0.0 0.39 10.6 0.0 2.1 1 1 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 CDW59865.1 - 0.099 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 CDW59865.1 - 0.24 11.9 1.7 1.2 9.7 0.1 2.5 2 1 0 2 2 2 0 ABC transporter rRNA_proc-arch PF13234.6 CDW59865.1 - 1.2 9.0 7.3 3.3 7.6 7.3 1.8 1 1 0 1 1 1 0 rRNA-processing arch domain AAA_17 PF13207.6 CDW59865.1 - 3.3 8.1 7.2 2.3 8.6 0.1 3.6 4 0 0 4 4 4 0 AAA domain PspC PF04024.12 CDW59866.1 - 1.8 8.4 5.4 23 4.9 1.8 3.6 2 0 0 2 2 2 0 PspC domain His_Phos_1 PF00300.22 CDW59869.1 - 2e-12 47.2 0.0 4.5e-12 46.1 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lyase_catalyt PF09093.11 CDW59869.1 - 0.12 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Lyase, catalytic DEAD PF00270.29 CDW59871.1 - 8.7e-30 103.8 0.3 3.1e-27 95.5 0.0 2.8 3 1 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW59871.1 - 1.2e-18 67.5 0.0 3.5e-18 66.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW59871.1 - 5.8e-05 23.2 0.2 0.0085 16.1 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Ribosomal_L23 PF00276.20 CDW59872.1 - 4.1e-16 59.1 1.3 4.1e-16 59.1 1.3 3.1 2 2 1 3 3 3 1 Ribosomal protein L23 Ribosomal_L23eN PF03939.13 CDW59872.1 - 9.5e-15 54.5 13.5 9.5e-15 54.5 13.5 2.2 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain RT_RNaseH_2 PF17919.1 CDW59872.1 - 0.093 12.8 0.5 0.23 11.5 0.5 1.7 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Dynein_light PF01221.18 CDW59873.1 - 4.9e-33 113.3 0.1 5.3e-33 113.2 0.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Imm48 PF15574.6 CDW59873.1 - 0.03 14.1 0.0 0.036 13.9 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 48 Ndr PF03096.14 CDW59875.1 - 2e-54 184.2 0.0 2.7e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Ndr family HlyE PF06109.13 CDW59877.1 - 0.11 11.8 0.8 0.16 11.2 0.1 1.5 2 0 0 2 2 2 0 Haemolysin E (HlyE) DUF4371 PF14291.6 CDW59878.1 - 0.001 18.7 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) VWA_2 PF13519.6 CDW59880.1 - 6.2e-13 49.3 0.2 4.3e-11 43.4 0.1 2.9 2 1 0 2 2 2 1 von Willebrand factor type A domain DUF2405 PF10293.9 CDW59880.1 - 0.0067 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) UIM PF02809.20 CDW59880.1 - 0.012 15.5 0.4 0.012 15.5 0.4 2.9 3 0 0 3 3 3 0 Ubiquitin interaction motif Ssl1 PF04056.14 CDW59880.1 - 0.047 13.5 0.2 0.36 10.6 0.1 2.0 1 1 1 2 2 2 0 Ssl1-like Glyco_hydro_53 PF07745.13 CDW59880.1 - 0.052 12.5 0.0 0.075 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 T2SSE_N PF05157.15 CDW59880.1 - 0.053 13.8 0.1 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein E, N-terminal domain CAMSAP_CC1 PF17095.5 CDW59880.1 - 0.19 11.6 2.7 9.2 6.2 0.4 2.6 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin RAP80_UIM PF18282.1 CDW59880.1 - 0.2 11.5 2.7 0.79 9.5 0.2 2.4 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif DUF4860 PF16152.5 CDW59881.1 - 0.015 15.2 0.1 0.031 14.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4860) zf-NADH-PPase PF09297.11 CDW59882.1 - 0.051 13.2 6.5 0.095 12.4 6.5 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain DUF5641 PF18701.1 CDW59883.1 - 3.6e-13 49.5 0.1 7.2e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Integrase_H2C2 PF17921.1 CDW59883.1 - 3.7e-10 39.8 1.3 3.7e-10 39.8 1.3 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain Usher_TcfC PF17271.2 CDW59884.1 - 2.1e-113 379.3 29.2 3e-113 378.8 29.2 1.2 1 0 0 1 1 1 1 TcfC Usher-like barrel domain CblD PF07434.11 CDW59884.1 - 1.4e-45 156.0 0.0 1.2e-43 149.5 0.0 2.7 1 1 0 1 1 1 1 CblD like pilus biogenesis initiator TcfC PF16967.5 CDW59884.1 - 4.4e-25 86.9 0.0 9.7e-25 85.8 0.0 1.6 1 0 0 1 1 1 1 E-set like domain CooC_C PF15976.5 CDW59884.1 - 2.4e-13 49.9 0.0 8.1e-13 48.2 0.0 1.9 2 0 0 2 2 2 1 CS1-pili formation C-terminal MFS_1 PF07690.16 CDW59885.1 - 1.4e-55 188.7 44.3 2.6e-47 161.5 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1970 PF09301.10 CDW59885.1 - 0.4 11.0 3.5 6.7 7.0 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1970) Halogen_Hydrol PF10112.9 CDW59885.1 - 0.41 10.6 2.8 2.2 8.2 0.1 2.6 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein UxaC PF02614.14 CDW59886.1 - 2.5e-221 735.4 0.1 3.5e-221 735.0 0.1 1.1 1 0 0 1 1 1 1 Glucuronate isomerase GD_AH_C PF04295.13 CDW59886.1 - 1.7e-154 514.4 0.0 2.2e-154 514.0 0.0 1.2 1 0 0 1 1 1 1 D-galactarate dehydratase / Altronate hydrolase, C terminus SAF PF08666.12 CDW59886.1 - 5.9e-15 55.7 0.5 1.2e-14 54.7 0.5 1.5 1 0 0 1 1 1 1 SAF domain SDF PF00375.18 CDW59887.1 - 3.9e-63 213.8 34.0 4.8e-63 213.5 34.0 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family TerC PF03741.16 CDW59888.1 - 4.3e-57 192.7 13.7 4.3e-57 192.7 13.7 2.8 3 0 0 3 3 3 1 Integral membrane protein TerC family GFO_IDH_MocA PF01408.22 CDW59889.1 - 2.2e-27 96.3 0.1 3.4e-27 95.7 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 CDW59889.1 - 0.029 15.0 0.0 0.1 13.2 0.0 1.9 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_3 PF03447.16 CDW59889.1 - 0.086 13.5 0.1 0.19 12.4 0.1 1.6 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain DUF218 PF02698.17 CDW59890.1 - 2.4e-20 72.9 0.0 2.8e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain DUF45 PF01863.17 CDW59891.1 - 3.3e-10 40.3 2.4 3.6e-10 40.3 2.4 1.2 1 1 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.10 CDW59891.1 - 2.2e-05 24.6 0.2 3.5e-05 23.9 0.2 1.4 1 0 0 1 1 1 1 WLM domain T4_Rnl2_C PF18043.1 CDW59891.1 - 0.097 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal LPD14 PF18827.1 CDW59891.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.6 1 1 1 2 2 2 0 Large polyvalent protein-associated domain 14 MTS PF05175.14 CDW59892.1 - 2.9e-06 26.9 0.0 0.00012 21.7 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase small domain RhoGAP PF00620.27 CDW59893.1 - 9.1e-35 119.7 3.8 6.7e-31 107.2 1.9 3.2 3 1 1 4 4 4 2 RhoGAP domain PH PF00169.29 CDW59893.1 - 2.8e-09 37.4 0.1 7.1e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 PH domain WW PF00397.26 CDW59893.1 - 1.6e-06 28.1 0.1 2.9e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 WW domain PH_9 PF15410.6 CDW59893.1 - 4.5e-06 27.0 0.0 9.7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_9 PF14604.6 CDW59893.1 - 0.0003 20.6 0.0 0.0006 19.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CDW59893.1 - 0.00065 19.3 0.1 0.0013 18.3 0.1 1.5 1 0 0 1 1 1 1 SH3 domain PH_11 PF15413.6 CDW59893.1 - 0.016 15.6 0.1 0.048 14.1 0.1 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain DUF2158 PF09926.9 CDW59893.1 - 0.093 12.5 0.5 26 4.6 0.0 3.2 2 1 1 3 3 3 0 Uncharacterized small protein (DUF2158) MTS PF05175.14 CDW59894.1 - 2.2e-12 46.9 0.0 3.3e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDW59894.1 - 3.2e-11 43.2 0.0 4.4e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 CDW59894.1 - 2.6e-10 40.3 0.1 3.3e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW59894.1 - 1.2e-09 38.7 0.1 2.6e-09 37.6 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CDW59894.1 - 1.7e-09 37.5 0.1 2.6e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 CDW59894.1 - 7.8e-06 26.6 0.0 1.8e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW59894.1 - 9.3e-06 26.2 0.1 2.2e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 CDW59894.1 - 9.6e-06 25.4 0.2 5.3e-05 23.0 0.2 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_9 PF08003.11 CDW59894.1 - 1.1e-05 24.5 0.1 1.8e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_15 PF09445.10 CDW59894.1 - 5.8e-05 22.7 0.0 8.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.6 CDW59894.1 - 0.00014 21.7 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain N6-adenineMlase PF10237.9 CDW59894.1 - 0.00044 20.1 0.0 0.00047 20.0 0.0 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase N6_Mtase PF02384.16 CDW59894.1 - 0.00075 18.8 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase CMAS PF02353.20 CDW59894.1 - 0.0019 17.5 0.0 0.0038 16.6 0.0 1.4 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 CDW59894.1 - 0.0093 16.0 0.0 0.016 15.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW59894.1 - 0.016 15.2 0.1 0.032 14.2 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain Pox_MCEL PF03291.16 CDW59894.1 - 0.024 13.8 0.0 0.036 13.2 0.0 1.3 1 0 0 1 1 1 0 mRNA capping enzyme B2 PF11473.8 CDW59894.1 - 0.025 14.4 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA binding protein B2 FtsJ PF01728.19 CDW59894.1 - 0.1 12.7 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase DNA_methylase PF00145.17 CDW59894.1 - 0.18 11.1 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase Folliculin PF11704.8 CDW59895.1 - 0.00066 19.6 0.1 0.0011 18.9 0.1 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport MORN PF02493.20 CDW59896.1 - 0.054 13.4 1.4 0.72 9.9 1.2 2.5 2 0 0 2 2 2 0 MORN repeat DUF1356 PF07092.12 CDW59897.1 - 1.3e-40 139.1 0.0 1.7e-40 138.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 CDW59897.1 - 0.015 15.3 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Pkinase PF00069.25 CDW59898.1 - 1.7e-26 93.1 0.0 2.1e-26 92.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW59898.1 - 1.1e-10 41.2 0.0 1.5e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW59898.1 - 0.0048 15.7 0.0 0.0065 15.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW59898.1 - 0.0096 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YqzE PF14038.6 CDW59899.1 - 0.041 13.9 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 YqzE-like protein Pcc1 PF09341.10 CDW59899.1 - 0.062 13.4 0.1 5.7 7.1 0.0 2.4 2 1 0 2 2 2 0 Transcription factor Pcc1 FTHFS PF01268.19 CDW59900.1 - 6.7e-169 562.6 0.0 1.1e-166 555.3 0.0 2.3 1 1 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 CDW59900.1 - 1.3e-68 229.3 4.7 1.6e-67 225.8 0.5 2.6 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CDW59900.1 - 4.9e-08 33.2 0.1 1.3e-07 31.9 0.1 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain WAP PF00095.21 CDW59902.1 - 7.7e-18 64.6 32.4 2e-08 34.5 2.7 3.5 3 1 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' CC PF04942.14 CDW59902.1 - 1.9 8.8 0.1 1.9 8.8 0.1 5.6 5 1 0 6 6 6 0 CC domain Somatomedin_B PF01033.17 CDW59902.1 - 6.1 7.3 26.9 1.3 9.4 2.0 3.6 3 1 0 3 3 3 0 Somatomedin B domain SpoU_methylase PF00588.19 CDW59903.1 - 1.5e-38 132.2 0.0 2.5e-38 131.5 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family NYN_YacP PF05991.11 CDW59903.1 - 4.7e-33 114.5 0.0 4.7e-33 114.5 0.0 1.6 2 0 0 2 2 2 1 YacP-like NYN domain SpoU_sub_bind PF08032.12 CDW59903.1 - 4.4e-19 68.5 0.0 2.9e-18 65.9 0.0 2.4 3 0 0 3 3 3 1 RNA 2'-O ribose methyltransferase substrate binding DEDD_Tnp_IS110 PF01548.17 CDW59903.1 - 0.019 14.9 0.0 0.019 14.9 0.0 2.1 2 0 0 2 2 2 0 Transposase Ribosomal_L7Ae PF01248.26 CDW59903.1 - 0.17 11.7 0.0 0.38 10.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family tRNA-synt_1e PF01406.19 CDW59904.1 - 4.1e-128 427.0 0.7 5.8e-128 426.5 0.1 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CDW59904.1 - 2.8e-16 59.3 0.9 3.4e-08 32.6 0.2 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) DALR_2 PF09190.11 CDW59904.1 - 6.4e-15 55.4 2.3 7.8e-15 55.1 0.2 2.3 2 1 0 2 2 2 1 DALR domain tRNA-synt_1f PF01921.18 CDW59904.1 - 4.8e-10 38.9 0.0 1.1e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1 PF00133.22 CDW59904.1 - 1.3e-07 30.3 0.0 6.4e-05 21.4 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1d PF00750.19 CDW59904.1 - 0.00067 18.7 0.7 0.025 13.5 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class I (R) Hexapep PF00132.24 CDW59905.1 - 5.8e-13 48.0 4.2 2.6e-07 30.1 0.1 3.3 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CDW59905.1 - 1.1e-05 25.1 2.7 0.014 15.1 0.3 3.4 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase tRNA-synt_1c PF00749.21 CDW59906.1 - 1.7e-123 411.5 0.0 2.1e-123 411.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain AAA_25 PF13481.6 CDW59907.1 - 6.7e-18 65.0 0.0 2e-17 63.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 CDW59907.1 - 1.1e-16 60.9 1.3 3.4e-09 36.4 0.1 2.1 1 1 1 2 2 2 2 KaiC ChlI PF13541.6 CDW59907.1 - 1.7e-10 40.8 0.1 6.4e-10 38.9 0.0 1.9 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase DnaB_C PF03796.15 CDW59907.1 - 2.2e-09 37.0 0.1 3.4e-08 33.1 0.1 2.3 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 CDW59907.1 - 3.7e-06 27.4 0.0 6.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Lon_C PF05362.13 CDW59907.1 - 1.5e-05 24.6 0.3 4.9e-05 23.0 0.0 2.0 3 0 0 3 3 3 1 Lon protease (S16) C-terminal proteolytic domain Rad51 PF08423.11 CDW59907.1 - 2.1e-05 23.9 0.7 0.001 18.4 0.3 2.4 2 1 0 2 2 2 1 Rad51 AAA_24 PF13479.6 CDW59907.1 - 0.00011 22.0 0.0 0.00062 19.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CDW59907.1 - 0.0002 21.9 0.1 0.00039 21.0 0.1 1.5 1 0 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 CDW59907.1 - 0.00023 20.9 0.0 0.00082 19.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CDW59907.1 - 0.00032 20.7 0.0 0.00062 19.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CDW59907.1 - 0.001 19.5 0.0 0.0018 18.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RecA PF00154.21 CDW59907.1 - 0.0024 17.4 0.2 0.0043 16.6 0.2 1.4 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_22 PF13401.6 CDW59907.1 - 0.0028 18.0 0.1 0.0073 16.6 0.1 1.7 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CDW59907.1 - 0.0044 16.3 0.0 0.0078 15.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin DUF2075 PF09848.9 CDW59907.1 - 0.0066 15.7 0.0 0.0089 15.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 CDW59907.1 - 0.0072 16.3 0.1 0.027 14.4 0.1 2.0 1 1 1 2 2 2 1 NTPase AAA_5 PF07728.14 CDW59907.1 - 0.0073 16.3 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CDW59907.1 - 0.008 15.9 0.1 0.015 15.0 0.1 1.5 1 1 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 CDW59907.1 - 0.012 15.5 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 NACHT domain KdpD PF02702.17 CDW59907.1 - 0.016 14.7 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain KTI12 PF08433.10 CDW59907.1 - 0.031 13.7 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 MCM PF00493.23 CDW59907.1 - 0.055 12.6 0.0 0.11 11.6 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_10 PF12846.7 CDW59907.1 - 0.062 12.2 0.0 0.093 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_19 PF13245.6 CDW59907.1 - 0.12 12.7 0.1 0.29 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.9 CDW59907.1 - 0.12 11.5 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 GDPD PF03009.17 CDW59908.1 - 1.2e-24 87.5 3.9 2.9e-14 53.4 0.2 2.2 1 1 1 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family GPDPase_memb PF10110.9 CDW59908.1 - 5.1e-14 51.8 14.5 5.1e-14 51.8 14.5 1.4 2 0 0 2 2 2 1 Membrane domain of glycerophosphoryl diester phosphodiesterase GDPD_2 PF13653.6 CDW59908.1 - 0.0025 18.2 1.8 0.0046 17.4 1.8 1.5 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Mtr2 PF10429.9 CDW59908.1 - 0.0028 17.6 0.7 0.005 16.8 0.7 1.3 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 AhpC-TSA PF00578.21 CDW59908.1 - 0.079 12.9 0.3 1.3 8.9 0.0 2.4 1 1 1 2 2 2 0 AhpC/TSA family Fib_alpha PF08702.10 CDW59908.1 - 0.47 10.6 2.6 2.7 8.2 0.7 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Cation_efflux PF01545.21 CDW59909.1 - 1e-30 107.0 12.4 1.4e-30 106.5 12.4 1.2 1 0 0 1 1 1 1 Cation efflux family DUF4130 PF13566.6 CDW59909.1 - 1.5e-20 73.7 0.0 3.5e-20 72.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4130 HHH_3 PF12836.7 CDW59909.1 - 5.5e-08 33.0 0.0 1.5e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.23 CDW59909.1 - 4.7e-06 26.2 0.0 1.2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CDW59909.1 - 0.00014 22.4 0.0 0.00048 20.7 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 CDW59909.1 - 0.011 15.8 0.0 0.039 14.0 0.0 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix motif Spore_YabQ PF09578.10 CDW59909.1 - 0.076 13.2 4.1 0.61 10.3 1.2 3.0 3 0 0 3 3 3 0 Spore cortex protein YabQ (Spore_YabQ) MOZ_SAS PF01853.18 CDW59910.1 - 3.8e-51 173.3 3.9 1.3e-25 90.1 0.3 2.2 1 1 1 2 2 2 2 MOZ/SAS family zf-MYST PF17772.1 CDW59910.1 - 1.2e-24 85.7 1.7 2.4e-24 84.7 0.5 2.0 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 CDW59910.1 - 0.00035 20.4 0.2 0.00071 19.4 0.2 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-U1 PF06220.12 CDW59910.1 - 0.11 12.3 0.3 0.24 11.2 0.3 1.5 1 0 0 1 1 1 0 U1 zinc finger zf-met PF12874.7 CDW59910.1 - 0.18 12.2 2.7 0.19 12.2 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 CDW59910.1 - 0.24 12.4 1.6 0.88 10.6 1.6 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger MAPEG PF01124.18 CDW59911.1 - 2.8e-22 79.0 5.0 5.7e-22 78.0 5.0 1.5 1 0 0 1 1 1 1 MAPEG family Phage_integrase PF00589.22 CDW59911.1 - 3e-19 69.4 0.2 7.8e-19 68.1 0.2 1.6 1 1 0 1 1 1 1 Phage integrase family DUF72 PF01904.18 CDW59911.1 - 1.3e-18 67.9 0.1 3.7e-18 66.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function DUF72 Molybdopterin PF00384.22 CDW59912.1 - 5.6e-103 345.2 0.2 7e-103 344.9 0.2 1.1 1 0 0 1 1 1 1 Molybdopterin oxidoreductase Molydop_binding PF01568.21 CDW59912.1 - 1.3e-24 86.4 0.1 5.7e-24 84.3 0.0 2.2 2 0 0 2 2 2 1 Molydopterin dinucleotide binding domain Molybdopterin_N PF18364.1 CDW59912.1 - 1.6e-11 44.0 0.0 5e-11 42.4 0.0 2.0 1 0 0 1 1 1 1 Molybdopterin oxidoreductase N-terminal domain TAT_signal PF10518.9 CDW59912.1 - 0.049 13.5 0.6 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence Cytochrom_NNT PF03264.14 CDW59913.1 - 9.2e-54 181.7 6.4 9.6e-52 175.2 6.6 2.1 2 0 0 2 2 2 1 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 CDW59913.1 - 9.2e-07 28.8 14.2 0.00053 19.9 7.7 3.3 2 1 1 3 3 3 1 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 CDW59913.1 - 1.8e-05 24.4 12.7 0.043 13.6 5.3 4.2 3 1 1 4 4 4 3 Doubled CXXCH motif (Paired_CXXCH_1) DHC PF09626.10 CDW59913.1 - 0.00095 20.0 14.7 0.066 14.1 0.4 4.2 2 1 2 4 4 4 2 Dihaem cytochrome c Cytochrome_P460 PF16694.5 CDW59913.1 - 0.0012 19.2 14.5 0.33 11.3 0.1 4.3 3 1 1 4 4 4 1 Cytochrome P460 Cytochrom_CIII PF02085.16 CDW59913.1 - 0.0021 18.4 14.8 1.8 9.0 12.8 3.2 2 1 0 2 2 2 1 Class III cytochrome C family Cytochrom_c3_2 PF14537.6 CDW59913.1 - 0.0022 18.4 15.6 0.016 15.7 7.4 3.2 2 1 1 3 3 3 1 Cytochrome c3 Cytochrome_CBB3 PF13442.6 CDW59913.1 - 0.0032 17.7 13.8 8.5 6.8 0.9 4.7 3 2 1 4 4 4 1 Cytochrome C oxidase, cbb3-type, subunit III zf-C2HCIx2C PF10782.9 CDW59913.1 - 0.016 15.1 0.4 0.23 11.4 0.0 2.9 3 0 0 3 3 3 0 Zinc-finger Cytochrome_C554 PF13435.6 CDW59913.1 - 0.021 15.7 12.7 16 6.5 0.1 4.1 2 1 1 4 4 4 0 Cytochrome c554 and c-prime zf-C4pol PF14260.6 CDW59913.1 - 0.14 12.6 3.2 0.22 12.0 0.7 2.4 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta PSCyt3 PF07627.11 CDW59913.1 - 0.3 11.4 10.8 13 6.1 0.9 4.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1588) CCP_MauG PF03150.14 CDW59913.1 - 0.62 10.7 10.9 28 5.3 0.1 4.0 2 1 0 3 3 3 0 Di-haem cytochrome c peroxidase Fer4_9 PF13187.6 CDW59913.1 - 1.5 9.0 5.1 1.7 8.9 1.0 2.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain Cytochrom_C_2 PF01322.20 CDW59913.1 - 4.4 8.2 12.7 0.49 11.3 4.9 3.0 3 0 0 3 3 3 0 Cytochrome C' FhuF_C PF11575.8 CDW59913.1 - 4.5 7.3 0.0 4.5 7.3 0.0 3.5 4 0 0 4 4 4 0 FhuF 2Fe-2S C-terminal domain zf-CHY PF05495.12 CDW59913.1 - 7.7 7.1 11.8 2.6 8.6 5.0 2.9 2 1 1 3 3 3 0 CHY zinc finger Defensin_5 PF18251.1 CDW59913.1 - 8 6.6 13.7 26 5.0 0.0 4.1 4 0 0 4 4 4 0 Fungal defensin Copsin CutC PF03932.14 CDW59914.1 - 1.3e-85 285.9 0.1 1.6e-85 285.7 0.1 1.0 1 0 0 1 1 1 1 CutC family YecM PF06185.12 CDW59915.1 - 1.1e-71 240.3 0.0 1.2e-71 240.1 0.0 1.0 1 0 0 1 1 1 1 YecM protein tRNA-synt_1d PF00750.19 CDW59916.1 - 8.9e-180 597.1 0.3 1.1e-179 596.7 0.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 CDW59916.1 - 5e-36 123.5 0.3 2.7e-35 121.1 0.3 2.2 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 CDW59916.1 - 1e-20 74.1 0.1 4.4e-20 72.1 0.1 2.1 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 CDW59916.1 - 0.0022 17.4 0.1 0.0035 16.7 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CDW59916.1 - 0.032 13.0 0.2 0.082 11.6 0.1 1.7 1 1 0 1 1 1 0 tRNA synthetases class I (M) Thiol_cytolys_C PF17440.2 CDW59916.1 - 0.064 13.4 0.5 0.13 12.4 0.5 1.5 1 0 0 1 1 1 0 Thiol-activated cytolysin beta sandwich domain tRNA-synt_1 PF00133.22 CDW59916.1 - 0.077 11.2 0.0 0.11 10.7 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Ribosomal_L20 PF00453.18 CDW59916.1 - 0.091 12.9 0.1 0.23 11.6 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L20 FHIPEP PF00771.20 CDW59917.1 - 2.1e-268 892.3 3.8 2.3e-268 892.1 3.8 1.0 1 0 0 1 1 1 1 FHIPEP family DUF4896 PF16237.5 CDW59917.1 - 8.8 6.3 11.9 0.069 13.0 3.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4896) Bac_export_2 PF01312.19 CDW59918.1 - 9.3e-124 412.9 0.0 1.1e-123 412.7 0.0 1.0 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family zf-BED PF02892.15 CDW59919.1 - 3.9e-06 26.8 0.0 7.6e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_12 PF18658.1 CDW59919.1 - 0.0054 16.3 0.1 0.011 15.3 0.0 1.6 2 0 0 2 2 2 1 Zinc-finger C2H2-type Dimer_Tnp_hAT PF05699.14 CDW59919.1 - 0.011 15.6 0.2 0.069 12.9 0.0 2.0 1 1 1 2 2 2 0 hAT family C-terminal dimerisation region zf-C2H2_4 PF13894.6 CDW59919.1 - 0.11 13.4 0.3 0.39 11.7 0.3 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-RING_2 PF13639.6 CDW59920.1 - 1.3e-06 28.7 4.9 1.3e-06 28.7 4.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CDW59920.1 - 7.6e-05 22.4 0.5 0.00029 20.5 0.5 2.1 1 1 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 CDW59920.1 - 8.8e-05 22.7 6.3 8.8e-05 22.7 6.3 1.9 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDW59920.1 - 0.00027 20.9 2.0 0.00027 20.9 2.0 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 CDW59920.1 - 0.001 18.9 5.9 0.001 18.9 5.9 2.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CDW59920.1 - 0.0037 17.1 5.5 0.013 15.4 5.5 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW59920.1 - 0.005 16.8 6.1 0.0093 15.9 6.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDW59920.1 - 0.034 14.0 3.5 0.081 12.8 3.5 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Di19 PF05605.12 CDW59920.1 - 0.04 14.2 2.3 2.2 8.6 0.1 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3331 PF11811.8 CDW59920.1 - 0.15 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3331) DZR PF12773.7 CDW59920.1 - 0.4 10.7 2.7 1.1 9.3 2.7 1.8 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_UBOX PF13445.6 CDW59920.1 - 1.2 9.3 6.0 1.9 8.6 3.4 2.5 2 1 1 3 3 3 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW59920.1 - 3.2 7.7 7.5 8.2 6.4 6.6 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CDW59920.1 - 6.2 7.1 12.9 12 6.1 6.4 3.1 2 1 0 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 CDW59920.1 - 8.6 6.1 11.1 2.3 7.9 7.2 2.1 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type dsrm PF00035.26 CDW59921.1 - 0.012 16.3 0.1 0.019 15.6 0.1 1.3 1 0 0 1 1 1 0 Double-stranded RNA binding motif SBP_bac_8 PF13416.6 CDW59921.1 - 0.14 11.9 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein zf-C3Hc3H PF13891.6 CDW59922.1 - 3.4e-10 40.1 18.2 1.7e-07 31.5 7.4 3.0 2 0 0 2 2 2 2 Potential DNA-binding domain FARP PF01581.16 CDW59923.1 - 1.6e-05 24.6 6.0 0.96 10.2 0.2 3.5 3 0 0 3 3 3 3 FMRFamide related peptide family UCH_C PF18031.1 CDW59923.1 - 0.28 11.1 6.1 8.2 6.4 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolases TACC_C PF05010.14 CDW59924.1 - 3.1e-16 59.8 35.4 4.9e-16 59.1 35.4 1.3 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF1729 PF08354.10 CDW59924.1 - 0.18 10.7 5.7 0.057 12.3 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1729) HWE_HK PF07536.14 CDW59924.1 - 0.19 12.4 4.8 5.4 7.8 0.7 2.8 2 0 0 2 2 2 0 HWE histidine kinase Spc7 PF08317.11 CDW59924.1 - 0.66 8.8 38.5 0.75 8.6 13.8 2.5 1 1 0 2 2 2 0 Spc7 kinetochore protein HBM PF16591.5 CDW59924.1 - 0.92 8.9 21.5 1.8 7.9 21.5 1.6 1 1 0 1 1 1 0 Helical bimodular sensor domain Seryl_tRNA_N PF02403.22 CDW59924.1 - 1.8 8.8 35.3 0.58 10.4 13.5 3.8 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.11 CDW59924.1 - 4.6 7.6 9.9 1.7 8.9 0.6 3.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Ribosomal_L4 PF00573.22 CDW59925.1 - 2.1e-41 141.8 0.0 3e-39 134.7 0.0 2.1 1 1 0 1 1 1 1 Ribosomal protein L4/L1 family Motile_Sperm PF00635.26 CDW59926.1 - 3.2e-09 36.6 0.0 4.5e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain LMF1 PF06762.14 CDW59927.1 - 7.8e-129 430.6 25.0 2.1e-68 231.4 3.2 2.1 1 1 1 2 2 2 2 Lipase maturation factor TspO_MBR PF03073.15 CDW59928.1 - 4.6e-07 30.0 5.3 6.9e-07 29.4 5.3 1.2 1 0 0 1 1 1 1 TspO/MBR family PBP_N PF17093.5 CDW59928.1 - 0.018 15.3 1.1 0.042 14.1 0.1 2.1 2 1 1 3 3 3 0 Penicillin-binding protein N-terminus EGF_2 PF07974.13 CDW59929.1 - 2.8e-08 34.0 58.9 0.0049 17.2 9.8 5.1 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 CDW59929.1 - 0.00013 22.2 10.7 0.00013 22.2 10.7 6.2 6 2 0 6 6 6 3 EGF-like domain hEGF PF12661.7 CDW59929.1 - 0.23 12.1 42.2 0.41 11.4 5.0 6.2 4 1 0 4 4 4 0 Human growth factor-like EGF Aminotran_3 PF00202.21 CDW59931.1 - 1.9e-47 161.9 0.1 2.1e-47 161.7 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_3 PF00202.21 CDW59932.1 - 1.9e-51 175.0 0.0 3.2e-51 174.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-III AA_kinase PF00696.28 CDW59932.1 - 3.3e-41 141.5 0.1 1.7e-40 139.1 0.1 1.9 2 0 0 2 2 2 1 Amino acid kinase family Beta_elim_lyase PF01212.21 CDW59932.1 - 0.017 14.4 0.0 0.033 13.5 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.19 CDW59932.1 - 0.075 12.0 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V ArgJ PF01960.18 CDW59933.1 - 6.6e-148 492.4 12.6 7.5e-148 492.3 12.6 1.0 1 0 0 1 1 1 1 ArgJ family Ribosomal_L5 PF00281.19 CDW59933.1 - 0.023 15.0 0.3 0.095 13.0 0.3 2.2 1 0 0 1 1 1 0 Ribosomal protein L5 FTHFS PF01268.19 CDW59934.1 - 1.6e-264 878.3 0.7 1.8e-264 878.1 0.7 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase CbiA PF01656.23 CDW59934.1 - 0.017 15.2 0.0 0.26 11.4 0.1 2.4 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Pox_A6 PF04924.12 CDW59934.1 - 0.16 10.9 0.8 0.7 8.8 0.8 1.7 1 1 1 2 2 2 0 Poxvirus A6 protein CSD PF00313.22 CDW59935.1 - 6.9e-26 89.9 1.5 7.5e-26 89.8 1.5 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDW59935.1 - 0.1 12.3 1.5 0.32 10.7 1.5 1.9 1 1 0 1 1 1 0 Ribonuclease B OB domain PLDc_2 PF13091.6 CDW59936.1 - 6e-39 133.0 0.0 1.3e-23 83.4 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CDW59936.1 - 3.2e-09 36.6 1.7 0.0023 18.0 0.4 2.4 2 0 0 2 2 2 2 Phospholipase D Active site motif tRNA-synt_2c PF01411.19 CDW59937.1 - 1.9e-190 634.0 0.0 1.9e-190 634.0 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (A) DHHA1 PF02272.19 CDW59937.1 - 2.2e-26 92.9 4.1 6.4e-26 91.4 4.1 1.9 1 0 0 1 1 1 1 DHHA1 domain tRNA_SAD PF07973.14 CDW59937.1 - 1.4e-21 76.3 1.2 3.8e-21 74.9 0.8 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF3659 PF12396.8 CDW59937.1 - 0.041 13.8 0.1 0.38 10.7 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) Takusan PF04822.13 CDW59937.1 - 0.047 13.6 0.8 0.11 12.5 0.8 1.6 1 0 0 1 1 1 0 Takusan DUF2362 PF10154.9 CDW59937.1 - 0.084 11.8 3.3 0.15 11.0 3.3 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) SIKE PF05769.11 CDW59937.1 - 0.1 12.5 7.9 0.12 12.3 5.5 2.2 2 0 0 2 2 2 0 SIKE family Nnf1 PF03980.14 CDW59937.1 - 0.11 12.9 6.3 0.091 13.2 3.5 2.2 2 0 0 2 2 2 0 Nnf1 ZapB PF06005.12 CDW59937.1 - 0.11 13.0 8.7 0.12 12.9 6.0 2.4 2 0 0 2 2 2 0 Cell division protein ZapB DUF4559 PF15112.6 CDW59937.1 - 0.28 10.8 7.1 1.2 8.7 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) bZIP_2 PF07716.15 CDW59937.1 - 3.8 7.7 7.2 10 6.3 7.2 1.7 1 0 0 1 1 1 0 Basic region leucine zipper BST2 PF16716.5 CDW59937.1 - 5.7 7.6 10.2 3 8.5 7.4 2.0 2 0 0 2 2 1 0 Bone marrow stromal antigen 2 GIT_CC PF16559.5 CDW59937.1 - 6.2 6.8 9.5 26 4.8 5.6 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Alfin PF12165.8 CDW59938.1 - 0.016 14.8 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 Alfin FGE-sulfatase PF03781.16 CDW59938.1 - 0.088 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Sulfatase-modifying factor enzyme 1 Acetyltransf_10 PF13673.7 CDW59939.1 - 2.8e-20 72.6 0.0 3.2e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW59939.1 - 2e-13 50.6 0.0 2.7e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CDW59939.1 - 3.9e-12 46.4 0.0 4.8e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CDW59939.1 - 1.9e-05 24.5 0.0 3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_5 PF13444.6 CDW59939.1 - 2e-05 25.2 0.1 0.05 14.3 0.1 2.3 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDW59939.1 - 2.3e-05 24.4 0.0 5e-05 23.4 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CDW59939.1 - 0.0021 18.2 0.0 0.0035 17.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 CDW59939.1 - 0.04 14.0 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CDW59939.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.7 1 1 0 1 1 1 0 Putative acetyl-transferase HlyC PF02794.16 CDW59939.1 - 0.16 11.8 0.1 0.47 10.3 0.1 1.7 1 1 0 1 1 1 0 RTX toxin acyltransferase family Retrotran_gag_2 PF14223.6 CDW59941.1 - 0.0016 18.1 0.0 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type Retrotran_gag_3 PF14244.6 CDW59942.1 - 1.9e-05 24.4 0.0 2.5e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 CDW59942.1 - 0.029 14.0 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) dsrm PF00035.26 CDW59943.1 - 3e-06 27.8 0.0 4.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif Gp_dh_C PF02800.20 CDW59946.1 - 9.9e-68 226.7 0.0 1.4e-67 226.2 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CDW59946.1 - 3.3e-36 123.7 0.1 1.1e-35 122.0 0.0 1.9 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 CDW59946.1 - 0.064 13.4 2.1 0.14 12.3 0.7 2.4 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus LRR_9 PF14580.6 CDW59947.1 - 1.8e-54 183.9 0.1 2.3e-54 183.5 0.1 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 CDW59947.1 - 6.5e-11 42.3 13.8 1.4e-05 25.3 1.0 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CDW59947.1 - 3.4e-09 36.3 2.0 8.9e-09 35.0 0.5 2.2 1 1 1 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 CDW59947.1 - 0.019 15.5 2.6 35 5.5 0.1 4.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 CDW59947.1 - 0.4 10.8 1.5 36 4.7 0.0 3.1 4 0 0 4 4 4 0 Leucine Rich repeat DUF778 PF05608.12 CDW59948.1 - 4.6e-32 111.9 3.9 3.1e-18 66.8 0.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF778) TPR_2 PF07719.17 CDW59949.1 - 3.6e-07 29.8 0.3 0.49 10.6 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW59949.1 - 1.9e-05 25.1 0.0 0.018 15.8 0.0 3.3 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CDW59949.1 - 3.4e-05 24.3 0.0 0.072 13.6 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CDW59949.1 - 9.7e-05 22.3 0.1 0.15 12.4 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW59949.1 - 0.0025 17.5 0.3 6.9 6.5 0.0 3.3 3 0 0 3 3 3 1 TPR repeat ANAPC3 PF12895.7 CDW59949.1 - 0.003 17.7 0.2 2.9 8.2 0.2 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 CDW59949.1 - 0.0074 16.9 0.0 22 5.8 0.0 3.6 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 CDW59949.1 - 0.0096 15.7 0.5 26 4.8 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDW59949.1 - 0.028 14.6 0.2 7.8 6.7 0.0 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat TipAS PF07739.13 CDW59949.1 - 0.088 13.4 0.1 0.37 11.3 0.0 2.0 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain ZnuA PF01297.17 CDW59949.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Motile_Sperm PF00635.26 CDW59950.1 - 6.7e-08 32.4 0.0 1.2e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain PK PF00224.21 CDW59951.1 - 7.5e-157 521.6 3.1 9.9e-157 521.3 3.1 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CDW59951.1 - 1.1e-25 90.1 0.1 4.3e-25 88.2 0.1 2.0 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CDW59951.1 - 4.8e-06 25.9 0.8 1.5e-05 24.2 0.9 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family BAR PF03114.18 CDW59952.1 - 2e-16 60.4 10.6 2.2e-16 60.2 10.6 1.0 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 CDW59952.1 - 0.0036 17.1 7.0 0.006 16.3 6.9 1.3 1 1 0 1 1 1 1 BAR domain of APPL family GP3_package PF16677.5 CDW59952.1 - 0.12 12.5 0.3 0.12 12.5 0.3 2.7 3 1 0 3 3 3 0 DNA-packaging protein gp3 Prefoldin_2 PF01920.20 CDW59952.1 - 0.2 11.6 4.0 1.2 9.1 0.2 2.9 2 1 1 3 3 3 0 Prefoldin subunit Gp-FAR-1 PF05823.12 CDW59952.1 - 0.37 11.1 9.1 0.18 12.2 0.7 2.8 1 1 1 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) PBECR1 PF18809.1 CDW59952.1 - 1.4 9.6 4.8 1.2 9.9 0.6 2.4 2 1 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 SWIRM-assoc_3 PF16498.5 CDW59952.1 - 1.9 8.8 5.0 8.4 6.7 1.1 3.2 3 1 0 3 3 3 0 SWIRM-associated domain at the C-terminal DUF16 PF01519.16 CDW59952.1 - 2 8.9 6.7 32 5.1 6.7 2.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 TFIIIC_sub6 PF10419.9 CDW59953.1 - 8.9e-05 22.3 0.0 0.00013 21.8 0.0 1.6 1 1 0 1 1 1 1 TFIIIC subunit triple barrel domain TIP49 PF06068.13 CDW59954.1 - 4.4e-156 519.5 1.0 5.5e-156 519.2 1.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CDW59954.1 - 1.6e-21 76.2 0.1 4.8e-21 74.7 0.1 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain RuvB_N PF05496.12 CDW59954.1 - 2.1e-09 37.3 0.3 1.5e-06 28.1 0.0 2.6 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 CDW59954.1 - 4.7e-09 36.8 0.1 2.2e-05 24.9 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CDW59954.1 - 0.00033 21.1 0.1 0.0029 18.0 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CDW59954.1 - 0.0013 18.4 0.0 0.0023 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW59954.1 - 0.0013 19.0 0.0 0.32 11.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CDW59954.1 - 0.0087 16.1 0.1 1.1 9.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CDW59954.1 - 0.012 16.2 0.0 0.085 13.4 0.0 2.3 2 1 1 3 3 3 0 AAA domain Sigma54_activat PF00158.26 CDW59954.1 - 0.024 14.4 0.0 8.4 6.1 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain DnaB_C PF03796.15 CDW59954.1 - 0.038 13.3 0.0 0.07 12.4 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 CDW59954.1 - 0.041 13.2 0.1 0.91 8.9 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CDW59954.1 - 0.064 13.6 0.5 0.78 10.1 0.5 2.4 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CDW59954.1 - 0.066 12.5 0.1 0.16 11.2 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 CDW59954.1 - 0.17 10.9 0.0 0.26 10.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Ist1 PF03398.14 CDW59955.1 - 9.6e-58 194.7 6.2 1.3e-57 194.3 6.2 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Herpes_UL52 PF03121.15 CDW59956.1 - 2.4e-10 40.2 0.2 9.5e-10 38.3 0.2 2.1 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase DUF3677 PF12432.8 CDW59957.1 - 1.7e-12 47.5 0.0 3.3e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3677) FAM76 PF16046.5 CDW59958.1 - 0.069 12.5 10.8 1.1 8.6 3.8 2.1 2 0 0 2 2 2 0 FAM76 protein TMF_DNA_bd PF12329.8 CDW59958.1 - 3.1 7.9 8.5 7.9 6.6 0.2 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SIL1 PF16782.5 CDW59958.1 - 5.9 6.0 7.7 1.3 8.1 0.1 2.7 2 1 1 3 3 3 0 Nucleotide exchange factor SIL1 PTPA PF03095.15 CDW59959.1 - 2.3e-59 201.3 0.2 2e-31 109.6 0.2 2.1 1 1 1 2 2 2 2 Phosphotyrosyl phosphate activator (PTPA) protein DUF4440 PF14534.6 CDW59960.1 - 0.0042 17.5 0.0 0.006 17.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 CDW59960.1 - 0.013 15.8 0.0 0.018 15.3 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain GTP_EFTU PF00009.27 CDW59961.1 - 9e-43 146.1 0.0 1.2e-42 145.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CDW59961.1 - 7.4e-30 103.5 1.3 1.2e-29 102.9 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CDW59961.1 - 1.5e-08 34.9 0.2 3.8e-08 33.6 0.2 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW59961.1 - 0.00014 21.9 0.1 0.001 19.1 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase PAM2 PF07145.15 CDW59961.1 - 0.0024 17.5 2.8 0.0025 17.4 0.5 2.2 2 0 0 2 2 2 1 Ataxin-2 C-terminal region UPF0552 PF10574.9 CDW59961.1 - 0.0062 15.9 0.2 0.03 13.7 0.1 2.0 2 0 0 2 2 2 1 Arp2/3-interacting proteins Arpin LPD34 PF18852.1 CDW59961.1 - 0.12 11.9 0.1 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 BTB PF00651.31 CDW59962.1 - 0.0021 18.3 0.4 0.035 14.3 0.1 2.8 1 1 0 2 2 2 1 BTB/POZ domain DUF4218 PF13960.6 CDW59962.1 - 0.056 13.1 0.0 0.19 11.3 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) EGF PF00008.27 CDW59963.1 - 8.6e-33 112.3 160.9 4.7e-06 26.8 6.4 12.0 11 0 0 11 11 11 9 EGF-like domain hEGF PF12661.7 CDW59963.1 - 3.4e-14 52.8 133.3 0.00035 21.1 6.7 12.4 11 0 0 11 11 11 8 Human growth factor-like EGF EGF_CA PF07645.15 CDW59963.1 - 5.2e-05 23.4 7.6 5.2e-05 23.4 7.6 11.9 4 4 7 11 11 11 5 Calcium-binding EGF domain EGF_2 PF07974.13 CDW59963.1 - 0.0041 17.5 14.5 0.0041 17.5 14.5 11.1 11 0 0 11 11 11 6 EGF-like domain cEGF PF12662.7 CDW59963.1 - 0.0091 15.9 4.4 0.0091 15.9 4.4 10.9 13 0 0 13 13 13 2 Complement Clr-like EGF-like ASFV_J13L PF05568.11 CDW59964.1 - 0.0087 15.8 4.7 0.011 15.5 4.7 1.0 1 0 0 1 1 1 1 African swine fever virus J13L protein MCLC PF05934.11 CDW59964.1 - 1 8.0 3.4 1.1 7.9 3.4 1.0 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) Acetyltransf_1 PF00583.25 CDW59965.1 - 1.2e-10 41.6 0.0 2.1e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CDW59965.1 - 6e-06 26.2 0.0 1.2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CDW59965.1 - 0.00046 20.5 0.0 0.0008 19.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CDW59965.1 - 0.0049 16.9 0.0 0.0084 16.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW59965.1 - 0.041 13.9 0.0 0.11 12.5 0.0 1.7 1 1 0 1 1 1 0 FR47-like protein DUF1168 PF06658.12 CDW59966.1 - 7.7e-26 90.5 0.8 7.7e-26 90.5 0.8 1.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1168) ThiF PF00899.21 CDW59968.1 - 6.6e-59 199.2 0.0 9e-59 198.8 0.0 1.0 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 CDW59968.1 - 1.6e-08 35.0 0.0 3.3e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 CDW59968.1 - 4.1e-06 26.9 0.8 0.0024 17.9 0.1 2.5 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 CDW59968.1 - 0.00047 20.6 0.0 0.0017 18.7 0.0 1.9 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CDW59968.1 - 0.0018 18.4 0.1 0.017 15.2 0.0 2.2 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CDW59968.1 - 0.0095 16.2 0.2 0.06 13.6 0.2 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NCD2 PF04905.13 CDW59968.1 - 0.06 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) TrkA_N PF02254.18 CDW59968.1 - 0.15 12.3 0.0 0.45 10.8 0.0 1.8 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_2 PF07992.14 CDW59968.1 - 0.18 11.0 0.0 0.34 10.1 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NusG PF02357.19 CDW59970.1 - 5.1e-29 100.6 0.1 7.5e-29 100.1 0.1 1.2 1 0 0 1 1 1 1 Transcription termination factor nusG KOW PF00467.29 CDW59970.1 - 3e-07 30.1 0.2 6.5e-07 29.1 0.2 1.6 1 0 0 1 1 1 1 KOW motif FMN_dh PF01070.18 CDW59971.1 - 1.5e-108 362.9 0.1 2.7e-108 362.1 0.1 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase ZnuA PF01297.17 CDW59971.1 - 8.8e-70 235.0 0.3 1.4e-69 234.3 0.3 1.4 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic IMPDH PF00478.25 CDW59971.1 - 7.2e-05 21.9 0.7 0.00068 18.7 0.3 2.7 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CDW59971.1 - 0.00092 18.6 0.2 0.72 9.1 0.0 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CDW59971.1 - 0.0013 18.3 0.2 0.45 9.9 0.0 2.8 2 1 1 3 3 3 2 Histidine biosynthesis protein NMO PF03060.15 CDW59971.1 - 0.0075 15.7 0.4 0.02 14.3 0.4 1.7 1 0 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.21 CDW59971.1 - 0.07 12.3 0.1 0.4 9.8 0.0 2.3 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase G3P_antiterm PF04309.12 CDW59971.1 - 0.079 12.4 0.2 1.6 8.1 0.0 2.9 3 0 0 3 3 3 0 Glycerol-3-phosphate responsive antiterminator Glu_synthase PF01645.17 CDW59971.1 - 0.13 11.4 0.1 0.35 10.0 0.1 1.7 1 1 0 1 1 1 0 Conserved region in glutamate synthase SDH_alpha PF03313.15 CDW59972.1 - 1.9e-72 244.1 13.0 2.7e-72 243.6 13.0 1.2 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 CDW59972.1 - 2.3e-15 57.3 0.1 2.5e-12 47.5 0.1 2.5 1 1 0 1 1 1 1 Serine dehydratase beta chain ACT PF01842.25 CDW59972.1 - 4.2e-07 29.6 0.2 1.9e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.6 CDW59972.1 - 0.13 12.9 0.2 0.47 11.1 0.1 1.9 2 0 0 2 2 2 0 ACT domain Ribosomal_L1 PF00687.21 CDW59973.1 - 1.6e-56 191.2 0.3 2.1e-56 190.9 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Ribosomal_L10 PF00466.20 CDW59974.1 - 5.3e-30 103.5 0.6 9.9e-30 102.6 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Ribosomal_L12 PF00542.19 CDW59975.1 - 7.9e-29 99.8 7.2 7.9e-29 99.8 7.2 2.0 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CDW59975.1 - 9.4e-19 66.9 6.8 9.4e-19 66.9 6.8 2.2 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain Surface_antigen PF11054.8 CDW59975.1 - 0.042 13.5 0.3 0.047 13.3 0.3 1.1 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen Ribosomal_60s PF00428.19 CDW59975.1 - 8 7.1 18.4 0.21 12.2 4.4 2.2 1 1 1 2 2 2 0 60s Acidic ribosomal protein HTH_3 PF01381.22 CDW59977.1 - 7.8e-06 25.9 0.0 1.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CDW59977.1 - 0.0023 17.9 0.0 0.0059 16.6 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CDW59977.1 - 0.018 15.4 0.0 0.031 14.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Phosducin PF02114.16 CDW59977.1 - 0.031 13.2 0.5 0.13 11.2 0.0 2.0 2 0 0 2 2 2 0 Phosducin MarR PF01047.22 CDW59977.1 - 0.11 12.4 0.0 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 MarR family HTH_26 PF13443.6 CDW59977.1 - 0.14 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain TTR-52 PF01060.23 CDW59978.1 - 0.00028 21.5 0.0 0.00037 21.1 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family TarS_C1 PF18674.1 CDW59978.1 - 0.17 11.8 0.0 0.22 11.5 0.0 1.1 1 0 0 1 1 1 0 TarS beta-glycosyltransferase C-terminal domain 1 PHP_C PF13263.6 CDW59979.1 - 0.2 11.5 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 PHP-associated VWA_2 PF13519.6 CDW59980.1 - 3.4e-06 27.7 0.0 7.9e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CDW59980.1 - 0.19 12.0 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain MRPL52 PF18699.1 CDW59982.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Mitoribosomal protein mL52 Anillin PF08174.11 CDW59983.1 - 1.4e-17 64.5 0.0 3.4e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 CDW59983.1 - 1.1e-09 38.8 0.1 1.1e-09 38.8 0.1 2.7 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 CDW59983.1 - 0.11 12.9 0.8 0.67 10.4 0.1 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain COX1 PF00115.20 CDW59984.1 - 1.1e-24 87.1 21.4 1.8e-21 76.5 13.1 3.1 1 1 1 2 2 2 2 Cytochrome C and Quinol oxidase polypeptide I DUF1449 PF07290.11 CDW59984.1 - 1 9.0 7.4 1.5 8.4 7.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) DUF2583 PF10762.9 CDW59984.1 - 8.1 6.9 8.6 4.5 7.7 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2583) NADHdh PF00146.21 CDW59985.1 - 1.1e-29 103.8 13.1 2.8e-29 102.4 13.1 1.6 1 1 0 1 1 1 1 NADH dehydrogenase Proton_antipo_M PF00361.20 CDW59986.1 - 2.7e-17 62.9 17.8 3.7e-17 62.5 16.9 1.6 1 1 0 1 1 1 1 Proton-conducting membrane transporter Cytochrome_B PF00033.19 CDW59987.1 - 7.5e-30 104.2 21.4 7.5e-30 104.2 21.4 2.6 2 1 0 2 2 2 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 CDW59987.1 - 3.5e-11 43.4 15.0 1.2e-08 35.1 15.0 2.2 1 1 0 1 1 1 1 Cytochrome b(N-terminal)/b6/petB PNTB_4TM PF12769.7 CDW59987.1 - 0.0054 17.2 1.4 0.015 15.8 1.4 1.9 1 0 0 1 1 1 1 4TM region of pyridine nucleotide transhydrogenase, mitoch Oxidored_q4 PF00507.19 CDW59988.1 - 5.3e-13 49.0 4.7 6.2e-13 48.8 4.4 1.3 1 1 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 CarS-like PF01864.17 CDW59988.1 - 0.0058 16.6 3.2 0.0091 16.0 2.9 1.6 1 1 1 2 2 2 1 CDP-archaeol synthase Steroid_dh PF02544.16 CDW59989.1 - 1.7e-22 80.0 4.9 1.7e-22 80.0 4.9 2.0 1 1 1 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 CDW59989.1 - 0.0057 17.0 3.8 0.013 15.9 1.5 2.2 2 0 0 2 2 2 1 Phospholipid methyltransferase V-SNARE_C PF12352.8 CDW59990.1 - 3.3e-11 43.3 1.4 6.9e-11 42.3 0.2 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus PI_PP_I PF18363.1 CDW59990.1 - 0.1 12.8 0.3 1.4 9.2 0.1 2.5 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain WD40 PF00400.32 CDW59991.1 - 5.3e-51 169.5 27.3 1.1e-07 32.4 0.4 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW59991.1 - 4.1e-14 52.6 2.5 0.0013 19.0 0.0 5.9 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 CDW59991.1 - 2.8e-13 49.5 2.0 5.4e-13 48.6 2.0 1.5 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 CDW59991.1 - 2.6e-08 33.0 10.1 0.0048 15.6 0.0 5.6 1 1 5 6 6 6 3 Nucleoporin Nup120/160 F-box PF00646.33 CDW59991.1 - 1.8e-07 30.8 1.0 3.6e-07 29.9 1.0 1.5 1 0 0 1 1 1 1 F-box domain Ge1_WD40 PF16529.5 CDW59991.1 - 0.0016 17.5 7.2 0.92 8.4 0.2 4.8 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CDW59991.1 - 0.024 14.0 0.0 0.98 8.7 0.0 2.9 2 1 2 4 4 4 0 WD40-like domain PQQ_2 PF13360.6 CDW59991.1 - 0.025 14.2 2.3 2.2 7.8 2.4 2.4 1 1 0 1 1 1 0 PQQ-like domain CDtoxinA PF03498.14 CDW59991.1 - 0.035 13.7 0.0 8.4 6.0 0.0 3.6 1 1 3 4 4 4 0 Cytolethal distending toxin A/C domain Hira PF07569.11 CDW59991.1 - 0.07 12.8 0.8 21 4.7 0.1 3.4 3 0 0 3 3 3 0 TUP1-like enhancer of split PRANC PF09372.10 CDW59991.1 - 0.087 13.2 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 PRANC domain PSI PF01437.25 CDW59991.1 - 1.7 9.2 5.7 55 4.4 0.2 4.6 4 1 0 4 4 4 0 Plexin repeat AAA_2 PF07724.14 CDW59992.1 - 1.7e-44 151.9 0.2 3.5e-44 150.9 0.2 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Ank_2 PF12796.7 CDW59992.1 - 1.3e-17 64.1 0.2 4.7e-10 39.9 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW59992.1 - 1.9e-14 52.3 1.7 2.7e-05 24.2 0.2 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 CDW59992.1 - 2.2e-14 53.3 5.9 1.7e-07 31.4 0.2 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CDW59992.1 - 6.7e-13 48.5 5.6 0.00013 22.3 0.3 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 CDW59992.1 - 1.2e-11 44.8 2.6 0.00036 21.0 0.1 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) AAA_5 PF07728.14 CDW59992.1 - 1.9e-09 37.6 0.0 7.3e-09 35.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 CDW59992.1 - 4.2e-08 33.1 0.8 1.9e-07 31.0 0.0 2.6 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CDW59992.1 - 1.7e-07 31.7 0.0 3.7e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CDW59992.1 - 5.6e-06 26.2 0.2 1.3e-05 25.0 0.1 1.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 CDW59992.1 - 0.00025 20.4 0.0 0.00068 19.0 0.0 1.8 1 1 1 2 2 2 1 Zeta toxin AAA_16 PF13191.6 CDW59992.1 - 0.0014 19.1 0.0 0.04 14.3 0.0 2.9 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CDW59992.1 - 0.0043 17.3 0.0 0.016 15.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CDW59992.1 - 0.0069 16.4 0.0 0.02 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CDW59992.1 - 0.0075 16.1 0.0 0.069 13.0 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 CDW59992.1 - 0.018 15.1 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 Torsin ATPase_2 PF01637.18 CDW59992.1 - 0.038 13.9 0.1 0.091 12.7 0.1 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea SRP54 PF00448.22 CDW59992.1 - 0.044 13.4 0.0 0.088 12.4 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 CDW59992.1 - 0.063 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 CDW59992.1 - 0.086 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDW59992.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AMOP PF03782.17 CDW59993.1 - 2.8e-34 118.3 0.7 4e-34 117.8 0.7 1.2 1 0 0 1 1 1 1 AMOP domain VWD PF00094.25 CDW59993.1 - 4.8e-07 30.2 0.2 8.1e-07 29.4 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain Pterin_bind PF00809.22 CDW59995.1 - 1.4e-69 234.4 0.0 2.3e-69 233.8 0.0 1.3 1 0 0 1 1 1 1 Pterin binding enzyme Tn7_Tnp_TnsA_N PF08722.11 CDW59995.1 - 1e-26 92.9 0.0 2.5e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 TnsA endonuclease N terminal PGM_PMM_I PF02878.16 CDW59995.1 - 1.2e-22 80.2 0.1 2.7e-21 75.7 0.0 2.3 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Thioredoxin_2 PF13098.6 CDW59995.1 - 1.7e-07 31.7 0.0 2e-05 25.0 0.0 2.8 2 0 0 2 2 2 1 Thioredoxin-like domain TraG-D_C PF12696.7 CDW59995.1 - 3.3e-05 23.9 0.2 9.7e-05 22.4 0.2 1.8 1 0 0 1 1 1 1 TraM recognition site of TraD and TraG TrwB_AAD_bind PF10412.9 CDW59995.1 - 0.0029 16.6 0.4 0.25 10.2 0.3 2.2 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain Tn7_Tnp_TnsA_C PF08721.11 CDW59995.1 - 0.059 14.0 0.1 0.13 12.9 0.1 1.7 1 0 0 1 1 1 0 TnsA endonuclease C terminal Toxin_GhoT_OrtT PF10753.9 CDW59995.1 - 0.073 13.3 2.8 0.16 12.2 2.8 1.6 1 0 0 1 1 1 0 Toxin GhoT_OrtT Thioredoxin PF00085.20 CDW59995.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin MFS_1 PF07690.16 CDW59996.1 - 1.4e-48 165.6 67.8 8e-45 153.3 41.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CDW59996.1 - 1.6e-08 33.9 29.3 5.2e-05 22.3 9.2 2.3 1 1 1 2 2 2 2 MFS_1 like family Nuc_H_symport PF03825.16 CDW59996.1 - 3.9e-05 22.8 22.9 0.0068 15.4 5.3 2.1 1 1 1 2 2 2 2 Nucleoside H+ symporter WAP PF00095.21 CDW59998.1 - 8.1e-122 397.4 232.7 7.7e-09 35.8 8.4 15.2 15 0 0 15 15 15 15 WAP-type (Whey Acidic Protein) 'four-disulfide core' PNP_UDP_1 PF01048.20 CDW59999.1 - 4.8e-43 147.1 0.1 5.6e-43 146.9 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily eIF-3c_N PF05470.12 CDW60000.1 - 1.1e-191 638.2 17.0 3.1e-191 636.7 17.0 1.6 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 CDW60000.1 - 1.5e-12 47.9 0.1 1e-11 45.3 0.0 2.4 2 0 0 2 2 2 1 PCI domain GyrB_insert PF18053.1 CDW60000.1 - 0.0061 16.5 0.0 0.02 14.8 0.0 1.9 1 0 0 1 1 1 1 DNA gyrase B subunit insert domain Macoilin PF09726.9 CDW60001.1 - 4e-05 22.4 2.0 5.5e-05 21.9 2.0 1.1 1 0 0 1 1 1 1 Macoilin family Med21 PF11221.8 CDW60001.1 - 0.0021 18.3 1.4 0.0023 18.2 1.4 1.3 1 1 0 1 1 1 1 Subunit 21 of Mediator complex ADIP PF11559.8 CDW60001.1 - 0.0049 17.0 1.9 0.0087 16.1 1.9 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 CDW60001.1 - 0.0067 16.7 0.8 0.0067 16.7 0.8 1.8 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Seryl_tRNA_N PF02403.22 CDW60001.1 - 0.0094 16.2 0.4 0.018 15.3 0.4 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 CDW60001.1 - 0.013 15.9 3.5 0.024 15.1 3.5 1.4 1 0 0 1 1 1 0 Cell division protein ZapB Tropomyosin PF00261.20 CDW60001.1 - 0.021 14.2 3.1 0.03 13.7 3.1 1.1 1 0 0 1 1 1 0 Tropomyosin Spc7 PF08317.11 CDW60001.1 - 0.03 13.2 1.9 0.045 12.6 1.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 CDW60001.1 - 0.035 14.6 3.7 0.061 13.8 3.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Ssl1 PF04056.14 CDW60001.1 - 0.059 13.2 0.2 0.098 12.5 0.2 1.2 1 0 0 1 1 1 0 Ssl1-like Golgin_A5 PF09787.9 CDW60001.1 - 0.078 12.4 4.6 0.022 14.2 1.8 1.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 Cnn_1N PF07989.11 CDW60001.1 - 0.11 12.6 4.4 0.22 11.7 4.4 1.4 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF1689 PF07954.11 CDW60001.1 - 0.13 12.7 0.0 1.8 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1689) Jnk-SapK_ap_N PF09744.9 CDW60001.1 - 0.14 12.4 5.9 0.039 14.2 3.0 1.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 bZIP_1 PF00170.21 CDW60001.1 - 0.16 12.1 5.7 0.11 12.6 2.5 2.0 2 0 0 2 2 2 0 bZIP transcription factor AKNA PF12443.8 CDW60001.1 - 0.25 12.0 2.7 2.3 8.9 0.2 2.5 2 0 0 2 2 2 0 AT-hook-containing transcription factor Uso1_p115_C PF04871.13 CDW60001.1 - 0.78 10.1 7.8 0.059 13.7 2.4 1.7 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region bZIP_2 PF07716.15 CDW60001.1 - 2.4 8.3 7.6 3.6 7.8 3.3 2.3 2 0 0 2 2 2 0 Basic region leucine zipper WAP PF00095.21 CDW60002.1 - 2.4e-14 53.5 16.1 2.4e-08 34.2 4.3 4.9 3 1 1 4 4 4 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' TIL PF01826.17 CDW60002.1 - 4.2e-09 36.5 14.1 4.2e-09 36.5 14.1 3.7 2 1 1 3 3 3 1 Trypsin Inhibitor like cysteine rich domain JAB PF01398.21 CDW60003.1 - 9.3e-08 32.1 0.0 1e-07 31.9 0.0 1.0 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PHD_2 PF13831.6 CDW60003.1 - 1.6 8.3 8.1 0.12 12.0 3.4 1.6 2 0 0 2 2 2 0 PHD-finger Haspin_kinase PF12330.8 CDW60004.1 - 3.2e-08 32.9 0.0 1.5e-07 30.7 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain DUF3400 PF11880.8 CDW60006.1 - 0.083 12.4 0.0 0.98 9.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3400) Histone PF00125.24 CDW60007.1 - 7.9e-54 181.5 1.5 8.7e-54 181.4 1.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW60007.1 - 0.00015 22.3 2.4 0.00019 22.0 2.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW60007.1 - 0.0002 21.4 0.2 0.00042 20.4 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW60007.1 - 0.00028 21.2 0.0 0.00042 20.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW60007.1 - 0.0043 17.3 0.0 0.0083 16.4 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CDW60007.1 - 0.06 13.4 0.1 0.11 12.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Rep_fac-A_C PF08646.10 CDW60009.1 - 3.3e-46 156.6 2.6 4.3e-46 156.3 2.6 1.1 1 0 0 1 1 1 1 Replication factor-A C terminal domain IBR PF01485.21 CDW60009.1 - 0.11 12.8 2.7 0.28 11.4 2.7 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-AN1 PF01428.16 CDW60009.1 - 0.23 11.7 3.1 0.55 10.4 3.1 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger SOAR PF16533.5 CDW60010.1 - 1.1e-32 112.0 3.5 1.1e-32 112.0 3.5 2.5 2 0 0 2 2 2 1 STIM1 Orai1-activating region SAM_2 PF07647.17 CDW60010.1 - 1.7e-06 28.0 0.0 4.8e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Hrs_helical PF12210.8 CDW60010.1 - 0.0051 17.3 1.5 0.0051 17.3 1.5 2.6 2 0 0 2 2 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate SAM_1 PF00536.30 CDW60010.1 - 0.0093 16.4 0.0 0.024 15.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF2203 PF09969.9 CDW60010.1 - 9.4 7.0 12.0 3.5 8.4 3.7 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Mt_ATP-synt_B PF05405.14 CDW60011.1 - 3.7e-20 72.2 0.5 4.5e-20 71.9 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) AlkA_N PF06029.11 CDW60011.1 - 0.0082 16.4 0.4 0.013 15.8 0.3 1.4 1 1 0 1 1 1 1 AlkA N-terminal domain CelTOS PF18659.1 CDW60011.1 - 0.076 13.5 0.3 6.6 7.2 0.1 2.2 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites Laminin_I PF06008.14 CDW60012.1 - 0.0036 17.1 5.7 0.0062 16.3 5.7 1.3 1 0 0 1 1 1 1 Laminin Domain I HR1 PF02185.16 CDW60012.1 - 0.11 12.6 5.8 0.36 11.0 5.8 1.9 1 0 0 1 1 1 0 Hr1 repeat Cnn_1N PF07989.11 CDW60012.1 - 0.11 12.7 4.6 0.32 11.2 4.6 1.8 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 ATG16 PF08614.11 CDW60012.1 - 0.11 12.7 11.0 0.26 11.5 11.0 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ERM PF00769.19 CDW60012.1 - 0.12 12.2 8.0 0.21 11.4 8.0 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family MPS2 PF17060.5 CDW60012.1 - 0.14 11.4 3.5 0.28 10.4 3.5 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 FUSC PF04632.12 CDW60012.1 - 1.4 7.3 2.9 2 6.9 2.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family BAR PF03114.18 CDW60013.1 - 2e-08 34.2 6.1 2.7e-08 33.7 6.1 1.1 1 0 0 1 1 1 1 BAR domain DUF4431 PF14485.6 CDW60014.1 - 0.051 13.4 0.1 0.51 10.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4431) Ndr PF03096.14 CDW60015.1 - 2.9e-41 141.0 0.3 4.9e-41 140.3 0.3 1.3 1 0 0 1 1 1 1 Ndr family DEAD PF00270.29 CDW60016.1 - 2.2e-31 109.0 1.1 4.9e-31 107.9 0.0 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW60016.1 - 1.9e-22 79.7 0.1 4.9e-22 78.4 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW60016.1 - 6e-07 29.6 0.0 1.5e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CDW60016.1 - 0.00024 20.5 0.1 0.00076 18.9 0.1 1.8 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 CDW60016.1 - 0.00042 19.6 0.2 0.0012 18.1 0.2 1.7 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase UvrD-helicase PF00580.21 CDW60016.1 - 0.011 15.2 0.0 0.011 15.2 0.0 2.2 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CDW60016.1 - 0.022 15.1 0.2 0.059 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CDW60016.1 - 0.049 13.4 0.0 0.15 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain Trypsin PF00089.26 CDW60017.1 - 1.4e-68 231.1 0.8 2.4e-58 197.5 0.3 2.1 2 0 0 2 2 2 2 Trypsin Trypsin_2 PF13365.6 CDW60017.1 - 1.9e-08 35.3 0.0 2.3e-06 28.6 0.0 2.3 2 0 0 2 2 2 2 Trypsin-like peptidase domain DASH_Ask1 PF08655.10 CDW60018.1 - 0.12 12.3 0.2 0.34 10.8 0.0 1.9 2 0 0 2 2 2 0 DASH complex subunit Ask1 Ycf54 PF10674.9 CDW60019.1 - 0.0093 16.2 0.1 0.018 15.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2488) Histone PF00125.24 CDW60021.1 - 1.5e-18 67.4 0.0 2e-18 67.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CDW60021.1 - 4.4e-16 58.3 0.7 7.5e-16 57.6 0.7 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CDW60021.1 - 0.00031 21.0 0.0 0.00042 20.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone eIF-1a PF01176.19 CDW60022.1 - 7.6e-17 60.9 0.0 1.3e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Astro_capsid_p PF12226.8 CDW60022.1 - 0.0022 17.2 1.4 0.0022 17.2 1.4 1.1 1 0 0 1 1 1 1 Turkey astrovirus capsid protein TLP-20 PF06088.11 CDW60022.1 - 0.051 13.5 0.8 0.059 13.3 0.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF3408 PF11888.8 CDW60022.1 - 0.2 11.8 11.0 6 7.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Nop14 PF04147.12 CDW60022.1 - 0.25 9.5 12.8 0.28 9.4 12.8 1.1 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 CDW60022.1 - 0.41 9.6 4.1 0.45 9.4 4.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 CDW60022.1 - 0.7 9.0 3.3 0.76 8.9 3.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 CDW60022.1 - 1.9 6.7 12.1 2.1 6.5 12.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 CDW60022.1 - 6.2 7.2 10.2 8.6 6.8 10.2 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ribosomal_S6 PF01250.17 CDW60023.1 - 9.2e-08 32.3 0.0 1.4e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S6 WD40 PF00400.32 CDW60024.1 - 4.3e-28 97.0 8.1 1.8e-07 31.7 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 CDW60024.1 - 1.8e-24 85.8 0.5 3.2e-23 81.8 0.1 2.9 4 0 0 4 4 4 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 CDW60024.1 - 5.3e-05 23.4 0.2 0.039 14.2 0.0 3.7 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW60024.1 - 0.00022 21.2 0.6 0.0093 15.9 0.0 2.6 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A AAA PF00004.29 CDW60026.1 - 4.1e-36 124.3 0.0 8.3e-36 123.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PGM_PMM_I PF02878.16 CDW60026.1 - 5.4e-14 52.1 0.0 7.2e-09 35.5 0.0 2.5 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 CDW60026.1 - 4.6e-11 42.7 0.2 1.3e-10 41.3 0.2 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 CDW60026.1 - 4.4e-08 33.3 0.0 9e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III AAA_lid_3 PF17862.1 CDW60026.1 - 3.7e-06 26.6 0.1 3.7e-06 26.6 0.1 2.5 3 0 0 3 3 2 1 AAA+ lid domain RuvB_N PF05496.12 CDW60026.1 - 1.2e-05 25.1 0.1 3.7e-05 23.5 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDW60026.1 - 7.3e-05 23.2 0.8 0.0012 19.3 0.0 2.6 2 1 0 3 3 2 1 AAA ATPase domain TniB PF05621.11 CDW60026.1 - 9.5e-05 21.9 0.0 0.17 11.3 0.0 3.2 2 1 0 3 3 3 1 Bacterial TniB protein AAA_14 PF13173.6 CDW60026.1 - 0.0002 21.4 0.0 0.00057 19.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW60026.1 - 0.00024 21.4 0.2 0.076 13.3 0.0 2.9 2 1 1 3 3 2 1 AAA domain AAA_5 PF07728.14 CDW60026.1 - 0.0003 20.8 0.0 0.0022 18.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CDW60026.1 - 0.00044 20.4 0.0 0.029 14.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 CDW60026.1 - 0.0013 18.4 0.1 1.2 8.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CDW60026.1 - 0.0052 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 CDW60026.1 - 0.012 15.8 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 CDW60026.1 - 0.024 15.0 0.0 0.065 13.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 CDW60026.1 - 0.039 13.7 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CDW60026.1 - 0.042 13.2 0.0 0.084 12.2 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CDW60026.1 - 0.045 12.9 0.2 0.095 11.9 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 CDW60026.1 - 0.062 13.9 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDW60026.1 - 0.076 12.2 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Rad17 PF03215.15 CDW60026.1 - 0.09 12.7 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain Sigma54_activ_2 PF14532.6 CDW60026.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_17 PF13207.6 CDW60026.1 - 0.15 12.5 0.0 0.41 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDW60026.1 - 0.18 11.3 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 CDW60026.1 - 0.18 11.8 0.0 0.49 10.4 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE WD40 PF00400.32 CDW60027.1 - 1.3e-44 149.3 30.4 1.7e-07 31.8 0.6 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW60027.1 - 8.9e-09 35.5 1.2 0.036 14.4 0.0 4.8 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 CDW60027.1 - 0.0013 17.6 1.2 3.2 6.4 0.0 3.6 2 1 2 4 4 4 3 Nup133 N terminal like DUF1416 PF07210.12 CDW60027.1 - 0.0054 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1416) Ge1_WD40 PF16529.5 CDW60027.1 - 0.016 14.2 0.1 2.4 7.0 0.0 3.3 3 1 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CDW60027.1 - 0.031 14.2 0.0 0.33 10.9 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 CDW60027.1 - 0.047 12.3 7.7 6.1 5.4 0.2 4.3 3 2 1 4 4 4 0 Nucleoporin Nup120/160 Sina PF03145.16 CDW60028.1 - 1.3e-80 270.1 0.5 1.8e-80 269.6 0.5 1.2 1 0 0 1 1 1 1 Seven in absentia protein family Trehalase PF01204.18 CDW60029.1 - 7.1e-08 31.7 1.5 7.1e-08 31.7 1.5 1.0 1 0 0 1 1 1 1 Trehalase Cu PF17563.2 CDW60029.1 - 0.092 13.0 3.0 0.14 12.4 3.0 1.2 1 0 0 1 1 1 0 Cupiennin Trehalase PF01204.18 CDW60030.1 - 6.9e-34 117.5 0.0 1.6e-28 99.9 0.0 2.0 1 1 1 2 2 2 2 Trehalase Integrase_H2C2 PF17921.1 CDW60032.1 - 8.6e-12 45.0 0.0 3.2e-11 43.2 0.0 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain RNase_P_pop3 PF08228.11 CDW60032.1 - 0.13 12.3 0.1 10 6.1 0.0 2.5 2 0 0 2 2 2 0 RNase P subunit Pop3 DUF871 PF05913.11 CDW60033.1 - 2.9e-115 385.3 1.3 6.1e-115 384.2 0.1 1.8 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF871) SIS_2 PF13580.6 CDW60033.1 - 2.8e-08 33.9 0.2 8e-08 32.4 0.2 1.7 1 0 0 1 1 1 1 SIS domain SIS PF01380.22 CDW60033.1 - 1.1e-07 31.8 0.1 2e-06 27.7 0.0 2.7 2 0 0 2 2 2 1 SIS domain Methyltransf_33 PF10017.9 CDW60033.1 - 0.09 11.9 0.1 0.56 9.3 0.0 2.1 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent DUF4398 PF14346.6 CDW60033.1 - 4.1 8.1 6.9 0.7 10.6 2.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) ApbA PF02558.16 CDW60034.1 - 1.5e-33 115.6 0.0 2.1e-33 115.1 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CDW60034.1 - 2.2e-30 105.4 0.0 3.8e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal NAD_Gly3P_dh_N PF01210.23 CDW60034.1 - 0.0027 17.7 0.0 0.0059 16.6 0.0 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 CDW60034.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase HTH_26 PF13443.6 CDW60034.1 - 0.15 12.5 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain AA_permease PF00324.21 CDW60035.1 - 1.1e-39 136.4 20.9 3.8e-39 134.6 20.9 1.7 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CDW60035.1 - 6.5e-17 61.5 18.1 1.1e-16 60.8 18.1 1.3 1 1 0 1 1 1 1 Amino acid permease DUF2456 PF10445.9 CDW60035.1 - 0.78 9.8 8.2 6.2 7.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2456) MIP PF00230.20 CDW60036.1 - 1.5e-48 165.5 20.6 1.8e-48 165.2 20.6 1.1 1 0 0 1 1 1 1 Major intrinsic protein Proton_antipo_M PF00361.20 CDW60038.1 - 7.7e-11 41.7 11.6 7.7e-11 41.7 11.6 1.7 1 1 1 2 2 2 1 Proton-conducting membrane transporter Apis_Csd PF11671.8 CDW60039.1 - 0.42 10.6 4.6 1.6 8.8 0.9 2.0 1 1 1 2 2 2 0 Complementary sex determiner protein DDE_1 PF03184.19 CDW60040.1 - 8.7e-15 54.8 0.0 2e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease BrkDBD PF09607.10 CDW60040.1 - 6.3e-13 48.3 0.6 3.2e-12 46.0 0.4 2.1 2 0 0 2 2 2 1 Brinker DNA-binding domain HTH_Tnp_Tc5 PF03221.16 CDW60040.1 - 1.1e-07 31.8 1.4 1.8e-07 31.1 0.3 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_Tnp_1 PF01527.20 CDW60040.1 - 0.0034 17.7 2.7 0.0034 17.7 2.7 2.0 2 1 0 2 2 2 1 Transposase DUF2344 PF10105.9 CDW60040.1 - 0.012 15.4 0.3 0.027 14.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2344) HTH_28 PF13518.6 CDW60040.1 - 0.035 14.2 0.5 0.1 12.7 0.4 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_29 PF13551.6 CDW60040.1 - 0.052 13.6 0.1 0.15 12.1 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.6 CDW60040.1 - 0.096 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain CENP-B_N PF04218.13 CDW60040.1 - 0.31 10.7 0.1 0.31 10.7 0.1 2.2 2 0 0 2 2 2 0 CENP-B N-terminal DNA-binding domain ICMT PF04140.14 CDW60041.1 - 9e-29 99.7 0.3 9e-29 99.7 0.3 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CDW60041.1 - 5.7e-10 39.5 0.4 5.7e-10 39.5 0.4 2.4 2 1 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 CDW60041.1 - 0.0026 17.3 0.2 0.0053 16.3 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 CDW60041.1 - 0.0082 15.7 0.7 0.0082 15.7 0.7 1.9 2 0 0 2 2 2 1 NnrU protein EpsG PF14897.6 CDW60041.1 - 0.085 12.2 16.0 0.16 11.3 16.0 1.4 1 0 0 1 1 1 0 EpsG family Dynactin PF12455.8 CDW60042.1 - 1.9e-31 109.4 1.8 1.9e-31 109.4 1.8 4.7 4 1 0 5 5 5 1 Dynein associated protein CAP_GLY PF01302.25 CDW60042.1 - 1.7e-22 79.2 0.3 3.8e-22 78.1 0.3 1.6 1 0 0 1 1 1 1 CAP-Gly domain DEAD PF00270.29 CDW60042.1 - 4e-18 65.8 3.9 5e-18 65.5 0.0 3.0 3 1 1 4 4 4 1 DEAD/DEAH box helicase Gla PF00594.20 CDW60042.1 - 0.29 11.4 3.4 0.32 11.2 0.2 2.4 2 0 0 2 2 2 0 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain FGF PF00167.18 CDW60043.1 - 1.6e-33 115.5 2.4 1.6e-33 115.5 2.4 1.5 2 0 0 2 2 2 1 Fibroblast growth factor Haspin_kinase PF12330.8 CDW60044.1 - 3.1e-07 29.7 0.8 5.3e-07 28.9 0.8 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Orai-1 PF07856.12 CDW60046.1 - 6.8e-51 172.4 6.9 8e-51 172.2 6.9 1.1 1 0 0 1 1 1 1 Mediator of CRAC channel activity Sbt_1 PF05982.12 CDW60046.1 - 0.0088 15.3 1.1 0.0088 15.3 1.1 1.6 2 0 0 2 2 2 1 Na+-dependent bicarbonate transporter superfamily SpoVAD PF07451.11 CDW60046.1 - 0.042 12.6 0.1 0.063 12.0 0.1 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) IgaA PF07095.11 CDW60046.1 - 0.045 11.7 0.1 0.072 11.1 0.1 1.3 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA DUF2207 PF09972.9 CDW60046.1 - 0.057 12.2 0.9 0.061 12.1 0.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3985 PF13153.6 CDW60046.1 - 0.48 10.5 6.5 6.5 6.8 6.5 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3985) DUF4133 PF13571.6 CDW60046.1 - 4.9 7.5 8.2 0.27 11.6 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Innexin PF00876.18 CDW60047.1 - 8.6e-65 219.3 15.4 9.5e-65 219.2 15.4 1.0 1 0 0 1 1 1 1 Innexin Ribosomal_S3Ae PF01015.18 CDW60048.1 - 5.4e-93 310.2 1.2 6.4e-93 309.9 1.2 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 CDW60048.1 - 0.013 15.0 0.0 0.027 14.0 0.0 1.5 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region Proteasom_PSMB PF10508.9 CDW60049.1 - 2.6e-66 224.1 0.5 1.3e-63 215.2 1.0 2.0 1 1 1 2 2 2 2 Proteasome non-ATPase 26S subunit Arm PF00514.23 CDW60050.1 - 2.2e-10 40.2 12.7 9.3e-06 25.5 0.2 6.0 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat APC_r PF05923.12 CDW60050.1 - 1.5e-09 37.3 8.5 4.3e-08 32.7 0.0 4.0 3 0 0 3 3 3 1 APC repeat APC_rep PF18797.1 CDW60050.1 - 5.8e-06 27.1 0.2 2.5e-05 25.1 0.2 2.2 1 0 0 1 1 1 1 Adenomatous polyposis coli (APC) repeat HEAT_2 PF13646.6 CDW60050.1 - 0.097 13.1 0.5 0.73 10.3 0.1 2.6 2 1 0 2 2 2 0 HEAT repeats CAP_GLY PF01302.25 CDW60051.1 - 1.2e-23 82.9 0.2 2.3e-23 82.0 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 CDW60051.1 - 3.9e-09 36.2 10.6 3.1e-05 23.7 4.5 2.5 2 0 0 2 2 2 2 CLIP1 zinc knuckle Golgin_A5 PF09787.9 CDW60051.1 - 0.00024 20.7 23.9 0.00024 20.7 23.9 3.5 1 1 0 3 3 3 1 Golgin subfamily A member 5 zf-U1 PF06220.12 CDW60051.1 - 0.04 13.7 1.5 0.1 12.4 1.5 1.7 1 0 0 1 1 1 0 U1 zinc finger bZIP_C PF12498.8 CDW60051.1 - 0.19 12.7 4.4 1.2 10.1 0.2 3.7 3 2 0 3 3 3 0 Basic leucine-zipper C terminal zf-CCHC_4 PF14392.6 CDW60051.1 - 1.3 8.8 5.7 0.3 10.8 0.6 2.5 3 0 0 3 3 3 0 Zinc knuckle Fib_alpha PF08702.10 CDW60051.1 - 2 8.6 39.7 2.7 8.2 0.8 5.5 3 2 1 5 5 5 0 Fibrinogen alpha/beta chain family Anillin PF08174.11 CDW60052.1 - 5.7e-12 46.3 0.1 1.1e-11 45.3 0.1 1.5 1 0 0 1 1 1 1 Cell division protein anillin PLAC9 PF15205.6 CDW60053.1 - 0.047 14.1 0.2 0.19 12.2 0.1 1.9 2 0 0 2 2 2 0 Placenta-specific protein 9 Tam41_Mmp37 PF09139.11 CDW60054.1 - 3e-97 325.9 0.1 4.3e-97 325.4 0.1 1.2 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Acetyltransf_1 PF00583.25 CDW60054.1 - 3e-10 40.4 0.1 1e-09 38.7 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDW60054.1 - 1.1e-08 35.4 0.0 7.8e-08 32.6 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW60054.1 - 3.1e-05 23.9 0.0 0.00047 20.1 0.0 2.5 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.7 CDW60054.1 - 6e-05 23.0 0.0 0.00018 21.5 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDW60054.1 - 0.067 13.3 0.2 0.52 10.4 0.1 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Q_salvage PF10343.9 CDW60055.1 - 5.6e-27 95.1 0.0 2.7e-22 79.7 0.0 2.1 1 1 1 2 2 2 2 Potential Queuosine, Q, salvage protein family DUF5639 PF18690.1 CDW60055.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5639) Mor PF08765.11 CDW60057.1 - 0.15 12.1 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Mor transcription activator family DUF3138 PF11336.8 CDW60057.1 - 0.3 9.7 5.1 0.32 9.6 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF2423 PF10338.9 CDW60057.1 - 1.5 9.1 6.2 4.4 7.6 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2423) SSDP PF04503.13 CDW60058.1 - 2.2e-13 51.2 26.9 2.6e-13 50.9 26.9 1.1 1 0 0 1 1 1 1 Single-stranded DNA binding protein, SSDP STT3 PF02516.14 CDW60059.1 - 1.7e-77 261.4 20.0 2.1e-77 261.1 20.0 1.0 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 CDW60059.1 - 0.16 12.2 15.3 0.019 15.2 11.0 1.6 2 0 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase UXS1_N PF11803.8 CDW60059.1 - 0.39 11.1 1.3 1 9.7 1.3 1.8 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal CLU PF13236.6 CDW60060.1 - 7.3e-61 205.8 0.0 1.3e-60 205.0 0.0 1.5 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 CDW60060.1 - 6.4e-47 159.8 1.0 4.3e-46 157.2 0.1 2.4 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 CDW60060.1 - 4.6e-16 58.9 1.1 5.4e-08 33.0 0.1 3.8 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 CDW60060.1 - 3.9e-06 26.6 1.5 0.27 11.2 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW60060.1 - 0.0016 17.9 0.7 0.024 14.0 0.7 2.2 1 1 0 1 1 1 1 MalT-like TPR region Cpn60_TCP1 PF00118.24 CDW60061.1 - 5.8e-155 516.6 3.8 7e-155 516.4 3.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family S-AdoMet_synt_N PF00438.20 CDW60061.1 - 0.049 14.3 0.5 0.23 12.1 0.1 2.3 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, N-terminal domain CBFD_NFYB_HMF PF00808.23 CDW60062.1 - 2e-22 79.2 1.9 2.8e-22 78.7 1.9 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CDW60062.1 - 9.6e-17 61.6 0.5 1.3e-16 61.2 0.5 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 CDW60062.1 - 0.0014 18.9 0.2 0.0051 17.1 0.1 1.8 2 0 0 2 2 2 1 CENP-S associating Centromere protein X TFIID-31kDa PF02291.15 CDW60062.1 - 0.019 15.0 0.1 0.027 14.5 0.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TAFII28 PF04719.14 CDW60062.1 - 0.026 14.6 0.4 0.052 13.7 0.4 1.6 1 1 0 1 1 1 0 hTAFII28-like protein conserved region DUF4382 PF14321.6 CDW60062.1 - 0.037 14.3 0.0 0.047 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4382) TAF PF02969.17 CDW60062.1 - 0.044 14.0 0.3 0.11 12.7 0.1 1.7 1 1 0 2 2 2 0 TATA box binding protein associated factor (TAF) YjgF_endoribonc PF14588.6 CDW60062.1 - 0.11 12.6 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 YjgF/chorismate_mutase-like, putative endoribonuclease Asp_protease_2 PF13650.6 CDW60065.1 - 2.2e-07 31.4 0.0 8.7e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW60065.1 - 2.4e-07 31.2 0.0 6.9e-07 29.7 0.0 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 CDW60065.1 - 7.5e-07 29.4 0.0 2.4e-06 27.8 0.0 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.23 CDW60065.1 - 2.1e-05 24.4 0.1 4e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Zinc knuckle Asp_protease PF09668.10 CDW60065.1 - 0.0012 18.6 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease Retrotrans_gag PF03732.17 CDW60065.1 - 0.0015 18.8 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein zf-CCHC_2 PF13696.6 CDW60065.1 - 0.0024 17.7 0.1 0.0053 16.5 0.1 1.6 1 0 0 1 1 1 1 Zinc knuckle Mito_carr PF00153.27 CDW60066.1 - 1.4e-61 204.4 0.1 1.4e-22 79.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CDW60066.1 - 0.021 14.0 1.1 16 4.6 0.1 3.3 3 1 1 4 4 4 0 Gammaproteobacterial serine protease ATP-gua_Ptrans PF00217.19 CDW60067.1 - 8.6e-83 277.0 0.0 1.4e-82 276.3 0.0 1.4 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 CDW60067.1 - 1.1e-12 48.1 1.4 1.2e-12 48.0 0.1 1.8 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, N-terminal domain CWC25 PF12542.8 CDW60067.1 - 1.8e-11 44.8 0.0 1.8e-11 44.8 0.0 2.6 2 1 0 2 2 2 1 Pre-mRNA splicing factor Las1 PF04031.13 CDW60068.1 - 1.8e-08 34.6 0.3 6.8e-08 32.8 0.0 2.0 2 0 0 2 2 2 1 Las1-like DEAD PF00270.29 CDW60069.1 - 1.3e-11 44.6 0.0 1.9e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CDW60069.1 - 1.7e-09 37.9 0.0 3e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 CDW60069.1 - 0.019 14.7 0.1 0.058 13.1 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein DEAD PF00270.29 CDW60070.1 - 6.5e-41 140.0 0.2 1e-40 139.4 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CDW60070.1 - 6.8e-28 97.2 2.2 1.9e-27 95.8 0.5 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CDW60070.1 - 0.0058 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ShK PF01549.24 CDW60071.1 - 1.7e-06 28.5 8.6 1.7e-06 28.5 8.6 2.6 2 1 0 2 2 2 1 ShK domain-like Integrase_H2C2 PF17921.1 CDW60072.1 - 7.6e-08 32.4 0.3 1.3e-07 31.6 0.3 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain PAC4 PF16093.5 CDW60074.1 - 5e-16 58.7 0.0 6.1e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 RVT_3 PF13456.6 CDW60074.1 - 0.026 14.3 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase-like EGF_2 PF07974.13 CDW60075.1 - 0.0001 22.6 9.2 0.0001 22.6 9.2 3.0 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 CDW60075.1 - 0.0058 17.2 7.6 0.046 14.4 7.6 2.7 1 0 0 1 1 1 1 Human growth factor-like EGF Arf PF00025.21 CDW60076.1 - 3.8e-45 153.5 1.0 1.6e-31 109.1 0.4 2.0 1 1 1 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 CDW60076.1 - 3.3e-07 30.5 0.0 4.8e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CDW60076.1 - 8e-05 21.9 0.3 0.16 11.1 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CDW60076.1 - 9.4e-05 22.1 0.0 0.0021 17.7 0.0 2.0 1 1 1 2 2 2 1 Ras family SRPRB PF09439.10 CDW60076.1 - 0.00029 20.3 0.1 0.0011 18.4 0.0 1.8 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CDW60076.1 - 0.00034 20.7 0.0 0.00042 20.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CDW60076.1 - 0.016 14.6 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 CDW60076.1 - 0.02 14.4 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 CDW60076.1 - 0.12 12.5 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Dynamin family TniB PF05621.11 CDW60076.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ATPase_2 PF01637.18 CDW60076.1 - 0.15 11.9 0.1 0.41 10.5 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea 6PF2K PF01591.18 CDW60076.1 - 0.15 11.3 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Ribosomal_S18 PF01084.20 CDW60077.1 - 5.4e-13 49.0 0.1 3.8e-12 46.2 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S18 RVT_1 PF00078.27 CDW60078.1 - 8.9e-05 22.1 0.0 0.00018 21.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C2H2 PF00096.26 CDW60078.1 - 0.12 12.8 1.0 0.68 10.5 1.0 2.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type DnaB_C PF03796.15 CDW60079.1 - 2.3e-74 250.0 0.0 1.6e-72 243.9 0.0 2.3 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain N6_N4_Mtase PF01555.18 CDW60079.1 - 3.9e-43 147.8 0.0 1.1e-42 146.4 0.0 1.7 1 1 0 1 1 1 1 DNA methylase IstB_IS21 PF01695.17 CDW60079.1 - 8.8e-19 67.9 0.0 4.5e-17 62.3 0.0 2.8 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_25 PF13481.6 CDW60079.1 - 1e-06 28.5 0.5 0.00034 20.3 0.1 2.7 2 1 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 CDW60079.1 - 9.3e-06 25.6 0.0 1.9e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial dnaA protein DnaB PF00772.21 CDW60079.1 - 0.00097 19.2 0.0 0.0025 17.9 0.0 1.6 1 0 0 1 1 1 1 DnaB-like helicase N terminal domain AAA PF00004.29 CDW60079.1 - 0.0017 18.8 0.1 0.013 15.9 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 CDW60079.1 - 0.0083 16.0 1.0 6 6.7 0.3 2.9 2 1 1 3 3 3 2 NTPase PhoH PF02562.16 CDW60079.1 - 0.021 14.3 0.0 0.067 12.6 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 CDW60079.1 - 0.025 13.8 0.0 7.3 5.8 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin Methyltransf_11 PF08241.12 CDW60079.1 - 0.056 14.1 0.1 4.7 7.9 0.0 3.6 3 1 0 3 3 3 0 Methyltransferase domain AAA_35 PF14516.6 CDW60079.1 - 0.095 11.5 0.0 0.17 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain HTH_3 PF01381.22 CDW60079.1 - 0.11 12.5 0.0 0.37 10.9 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix AAA_19 PF13245.6 CDW60079.1 - 0.59 10.5 3.8 15 5.9 0.2 3.4 3 1 0 3 3 3 0 AAA domain Phage_ASH PF10554.9 CDW60081.1 - 6.1e-28 97.3 12.0 4.1e-18 65.7 0.1 3.6 4 0 0 4 4 4 2 Ash protein family Phage_pRha PF09669.10 CDW60081.1 - 0.00019 22.0 0.0 0.00053 20.5 0.0 1.8 1 0 0 1 1 1 1 Phage regulatory protein Rha (Phage_pRha) Cerato-platanin PF07249.12 CDW60081.1 - 0.04 14.1 0.1 0.093 12.9 0.1 1.6 1 0 0 1 1 1 0 Cerato-platanin Phage_pRha PF09669.10 CDW60082.1 - 1.9e-13 50.8 0.1 6.6e-13 49.0 0.0 1.8 2 0 0 2 2 2 1 Phage regulatory protein Rha (Phage_pRha) HTH_24 PF13412.6 CDW60082.1 - 0.0014 18.1 0.0 0.14 11.7 0.0 2.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Trimer_CC PF08954.11 CDW60082.1 - 0.042 13.4 2.2 0.066 12.8 0.2 2.1 2 0 0 2 2 2 0 Trimerisation motif Baculo_DNA_bind PF04786.12 CDW60082.1 - 0.043 13.2 0.8 0.099 12.0 0.8 1.6 1 1 0 1 1 1 0 ssDNA binding protein PaaX PF07848.12 CDW60082.1 - 0.048 13.9 0.0 0.15 12.3 0.0 1.9 2 0 0 2 2 2 0 PaaX-like protein Inj_translocase PF16928.5 CDW60082.1 - 0.066 12.6 0.1 0.095 12.1 0.1 1.2 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome Noelin-1 PF12308.8 CDW60082.1 - 0.1 12.6 1.3 1 9.4 0.3 2.5 2 1 1 3 3 3 0 Neurogenesis glycoprotein SlyX PF04102.12 CDW60082.1 - 0.17 12.5 2.1 0.67 10.6 2.0 2.0 1 1 0 1 1 1 0 SlyX MtrG PF04210.13 CDW60082.1 - 0.18 11.7 1.3 1.8 8.5 0.4 2.6 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G HTH_3 PF01381.22 CDW60083.1 - 6.5e-11 42.1 0.0 1.1e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 CDW60083.1 - 9.2e-10 38.4 0.0 2.5e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 CDW60083.1 - 1.8e-08 34.6 0.0 4.8e-08 33.2 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain Peptidase_S24 PF00717.23 CDW60083.1 - 0.00026 20.9 0.0 0.02 14.8 0.0 2.3 2 0 0 2 2 2 1 Peptidase S24-like HTH_25 PF13413.6 CDW60083.1 - 0.0052 16.6 0.0 0.0089 15.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_26 PF13443.6 CDW60083.1 - 0.0077 16.6 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain SapC PF07277.11 CDW60083.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 SapC BrkDBD PF09607.10 CDW60084.1 - 2.3e-13 49.7 0.7 4.7e-13 48.7 0.7 1.5 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_Tnp_Tc5 PF03221.16 CDW60084.1 - 2.6e-12 46.6 1.2 6.4e-12 45.3 0.4 2.0 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain HTH_28 PF13518.6 CDW60084.1 - 0.001 19.1 0.1 0.0022 18.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 CDW60084.1 - 0.0035 17.1 0.0 0.0068 16.2 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_1 PF01527.20 CDW60084.1 - 0.014 15.7 7.4 0.016 15.5 4.9 2.2 2 1 1 3 3 3 0 Transposase HTH_29 PF13551.6 CDW60084.1 - 0.019 15.0 0.1 0.037 14.1 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn helix CENP-B_N PF04218.13 CDW60084.1 - 0.059 13.0 0.2 0.12 12.1 0.2 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain zf-SNAP50_C PF12251.8 CDW60084.1 - 0.11 12.1 0.0 0.15 11.7 0.0 1.3 1 1 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal HA PF03457.14 CDW60084.1 - 0.18 12.2 2.5 0.32 11.4 1.1 2.1 1 1 1 2 2 2 0 Helicase associated domain DUF1387 PF07139.11 CDW60085.1 - 1.4e-18 67.7 5.6 1.4e-18 67.7 5.6 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1387) Spc7 PF08317.11 CDW60085.1 - 0.21 10.5 10.4 0.32 9.8 10.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein HAUS6_N PF14661.6 CDW60085.1 - 0.29 10.7 8.0 0.75 9.3 8.0 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Prominin PF05478.11 CDW60085.1 - 0.3 9.0 4.6 0.41 8.6 4.6 1.1 1 0 0 1 1 1 0 Prominin STAT_alpha PF01017.20 CDW60085.1 - 2.5 8.0 7.6 3.9 7.4 1.6 2.4 1 1 1 2 2 2 0 STAT protein, all-alpha domain Rhomboid PF01694.22 CDW60087.1 - 5.3e-25 88.2 13.0 5.3e-25 88.2 10.5 2.1 1 1 1 2 2 2 1 Rhomboid family RWD PF05773.22 CDW60087.1 - 1.8e-17 63.7 0.1 3.3e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 RWD domain PB1 PF00564.24 CDW60087.1 - 1.6e-12 47.2 0.0 3.1e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 PB1 domain PDZ PF00595.24 CDW60087.1 - 9.8e-10 38.7 0.0 1.9e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW60087.1 - 2.3e-08 33.7 0.1 5.5e-08 32.5 0.1 1.7 1 0 0 1 1 1 1 PDZ domain DFRP_C PF16543.5 CDW60087.1 - 0.0067 16.9 1.7 0.023 15.2 1.7 1.9 1 0 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 Rhomboid_SP PF12595.8 CDW60087.1 - 0.031 13.6 0.2 0.031 13.6 0.2 2.7 2 1 0 2 2 2 0 Rhomboid serine protease CoA_binding_3 PF13727.6 CDW60087.1 - 0.14 12.2 2.1 0.61 10.1 0.0 2.7 3 0 0 3 3 3 0 CoA-binding domain AI-2E_transport PF01594.16 CDW60087.1 - 0.72 8.9 10.7 0.14 11.3 7.0 1.6 2 0 0 2 2 2 0 AI-2E family transporter DUF1772 PF08592.11 CDW60087.1 - 0.86 9.9 2.9 1.1 9.5 1.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) INCENP_ARK-bind PF03941.15 CDW60088.1 - 1.4e-07 31.3 0.1 2.9e-07 30.3 0.1 1.6 1 1 0 1 1 1 1 Inner centromere protein, ARK binding region K1377 PF15352.6 CDW60088.1 - 0.0066 14.8 7.4 0.0077 14.6 7.4 1.0 1 0 0 1 1 1 1 Susceptibility to monomelic amyotrophy SAM_4 PF18017.1 CDW60089.1 - 1.1e-08 34.9 0.0 2.3e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CDW60089.1 - 7.3e-05 22.8 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CDW60089.1 - 0.064 13.7 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) BRCT PF00533.26 CDW60090.1 - 8.7e-50 167.0 0.7 3.2e-13 49.9 0.0 5.4 5 0 0 5 5 5 5 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CDW60090.1 - 3.7e-46 154.9 1.3 4.2e-14 52.2 0.0 6.5 6 0 0 6 6 6 4 twin BRCT domain BRCT_2 PF16589.5 CDW60090.1 - 4.1e-23 81.6 0.0 0.00022 21.5 0.0 5.4 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CDW60090.1 - 2.8e-09 37.1 0.5 0.45 10.8 0.0 5.3 5 0 0 5 5 5 4 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 CDW60090.1 - 5.7e-09 36.0 1.3 0.61 10.2 0.1 5.1 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain MEF2_binding PF09047.10 CDW60090.1 - 2.7 7.9 5.9 10 6.1 0.2 2.7 2 0 0 2 2 2 0 MEF2 binding Ssu72 PF04722.13 CDW60091.1 - 7.2e-79 263.8 1.0 7.9e-79 263.7 1.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein ACT_6 PF13740.6 CDW60091.1 - 0.19 11.7 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 ACT domain Trypsin PF00089.26 CDW60092.1 - 5.6e-14 52.5 0.0 1.2e-05 25.2 0.0 3.0 3 0 0 3 3 3 2 Trypsin FCH PF00611.23 CDW60093.1 - 0.0014 18.9 2.6 0.015 15.6 0.1 3.1 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain GCK PF07802.11 CDW60093.1 - 0.047 14.1 4.6 3.1 8.3 0.1 2.8 2 0 0 2 2 2 0 GCK domain Importin_rep_6 PF18829.1 CDW60093.1 - 0.074 13.2 1.9 3 8.0 0.2 2.8 3 0 0 3 3 3 0 Importin repeat 6 Pkinase PF00069.25 CDW60094.1 - 6e-61 206.1 0.0 1e-60 205.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60094.1 - 2.5e-31 108.9 0.0 3.5e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW60094.1 - 0.0021 17.4 0.2 0.032 13.5 0.2 2.3 1 1 0 1 1 1 1 Kinase-like Borrelia_P83 PF05262.11 CDW60094.1 - 0.21 10.0 6.5 0.32 9.5 6.5 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein 3Beta_HSD PF01073.19 CDW60095.1 - 3.6e-13 49.2 0.0 4.1e-13 49.0 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CDW60095.1 - 5.8e-06 25.9 0.0 6.6e-06 25.8 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CDW60095.1 - 0.00023 20.4 0.0 0.00026 20.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein TypeIII_RM_meth PF12564.8 CDW60095.1 - 0.087 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Type III restriction/modification enzyme methylation subunit NAD_binding_4 PF07993.12 CDW60095.1 - 0.1 11.7 0.0 0.24 10.5 0.0 1.6 2 0 0 2 2 2 0 Male sterility protein PigN PF04987.14 CDW60096.1 - 1.5e-72 244.9 63.8 2.2e-72 244.4 63.8 1.3 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 CDW60096.1 - 2.2e-13 50.5 0.3 7.6e-13 48.8 0.3 1.7 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CDW60096.1 - 2.7e-05 23.7 0.0 4.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 CDW60096.1 - 3.1e-05 23.5 0.0 5.7e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 CDW60096.1 - 0.12 12.5 0.1 0.36 10.9 0.1 1.7 2 0 0 2 2 2 0 PglZ domain UPF1_Zn_bind PF09416.10 CDW60097.1 - 6.5e-13 48.9 4.5 4.2e-12 46.3 0.4 2.1 1 1 1 2 2 2 2 RNA helicase (UPF2 interacting domain) Glyco_trans_2_3 PF13632.6 CDW60098.1 - 3.2e-23 82.7 3.6 4.4e-23 82.2 3.5 1.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CDW60098.1 - 0.00051 20.0 0.1 0.00076 19.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 HTH_Tnp_4 PF13613.6 CDW60098.1 - 0.042 13.6 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease DUF4190 PF13828.6 CDW60098.1 - 0.11 12.2 0.1 0.26 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4190) zf-CCHC PF00098.23 CDW60100.1 - 1.3e-06 28.2 2.2 2.4e-06 27.4 2.2 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 CDW60100.1 - 0.0033 17.1 1.1 0.0053 16.5 1.1 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 CDW60100.1 - 0.024 14.5 0.6 0.051 13.4 0.6 1.5 1 0 0 1 1 1 0 Zinc knuckle Proton_antipo_M PF00361.20 CDW60103.1 - 3.8e-09 36.2 1.1 4.7e-09 35.9 1.1 1.1 1 0 0 1 1 1 1 Proton-conducting membrane transporter Mre11_DNA_bind PF04152.14 CDW60106.1 - 7.5e-33 114.2 0.6 1.2e-32 113.6 0.6 1.3 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 CDW60106.1 - 2.7e-11 44.4 0.4 7e-11 43.0 0.4 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CDW60106.1 - 7.9e-06 26.2 0.0 2.8e-05 24.4 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF5580 PF17743.1 CDW60106.1 - 0.017 13.7 0.1 0.024 13.2 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Autotransporter PF03797.19 CDW60107.1 - 1.9e-17 63.7 13.2 1.9e-17 63.7 13.2 2.9 3 0 0 3 3 3 1 Autotransporter beta-domain Aldo_ket_red PF00248.21 CDW60108.1 - 1.9e-49 168.4 0.0 1.7e-47 162.1 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family RsdA_SigD_bd PF16751.5 CDW60108.1 - 0.05 13.9 0.4 0.14 12.4 0.4 1.7 1 0 0 1 1 1 0 Anti-sigma-D factor RsdA to sigma factor binding region Methyltransf_20 PF12147.8 CDW60109.1 - 9.1e-150 498.0 0.0 1.5e-149 497.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Hydrolase_4 PF12146.8 CDW60109.1 - 3e-63 213.3 0.2 9e-63 211.7 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 CTP_transf_1 PF01148.20 CDW60109.1 - 1.6e-53 182.2 3.5 1.6e-53 182.2 3.5 2.3 2 1 0 2 2 1 1 Cytidylyltransferase family DUF2773 PF10971.8 CDW60109.1 - 1.4e-33 114.9 3.2 4.3e-33 113.3 3.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2773) DSPc PF00782.20 CDW60109.1 - 6.3e-25 87.5 0.0 1.3e-24 86.5 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Abhydrolase_6 PF12697.7 CDW60109.1 - 8.9e-08 33.0 4.4 8.9e-08 33.0 4.4 2.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family PAP2_3 PF14378.6 CDW60109.1 - 1.8e-05 24.5 7.0 1.8e-05 24.5 7.0 2.2 2 0 0 2 2 2 1 PAP2 superfamily Abhydrolase_1 PF00561.20 CDW60109.1 - 3.1e-05 23.7 0.1 9.1e-05 22.2 0.1 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Methyltransf_31 PF13847.6 CDW60109.1 - 0.00034 20.4 0.0 0.00081 19.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Y_phosphatase PF00102.27 CDW60109.1 - 0.0034 17.0 0.0 0.0063 16.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Bactofilin PF04519.13 CDW60109.1 - 0.037 14.3 0.1 0.091 13.1 0.1 1.6 1 0 0 1 1 1 0 Polymer-forming cytoskeletal Arabinose_bd PF12625.7 CDW60109.1 - 0.091 12.8 0.4 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Arabinose-binding domain of AraC transcription regulator, N-term CarS-like PF01864.17 CDW60109.1 - 0.097 12.7 1.2 0.18 11.8 0.3 1.9 2 0 0 2 2 2 0 CDP-archaeol synthase Flavodoxin_2 PF02525.17 CDW60110.1 - 2.9e-47 161.0 0.0 3.3e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 CDW60110.1 - 3.5e-11 43.1 0.0 4.5e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase DUF3418 PF11898.8 CDW60111.1 - 5.7e-48 164.0 0.7 8.1e-48 163.5 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3418) OB_NTP_bind PF07717.16 CDW60111.1 - 4.1e-20 71.9 0.0 7.7e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CDW60111.1 - 1.5e-18 67.1 0.0 3.9e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CDW60111.1 - 2e-12 47.5 0.0 9.8e-12 45.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CDW60111.1 - 1.1e-06 28.6 0.0 2.6e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 CDW60111.1 - 7.3e-05 23.1 0.1 0.00028 21.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CDW60111.1 - 0.00014 21.0 0.0 0.00031 19.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 CDW60111.1 - 0.00025 21.3 0.2 0.0012 19.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CDW60111.1 - 0.0019 18.1 2.8 0.013 15.4 0.8 2.9 2 1 0 2 2 2 1 NACHT domain PhoH PF02562.16 CDW60111.1 - 0.01 15.3 0.0 0.028 13.9 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.15 CDW60111.1 - 0.011 15.7 0.0 6 6.8 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CDW60111.1 - 0.014 15.2 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CDW60111.1 - 0.02 14.2 0.0 0.036 13.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 CDW60111.1 - 0.051 14.1 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CDW60111.1 - 0.1 13.1 0.1 0.96 10.0 0.0 2.6 3 0 0 3 3 3 0 ABC transporter NTPase_1 PF03266.15 CDW60111.1 - 0.14 12.0 0.7 0.39 10.6 0.7 1.7 1 1 0 1 1 1 0 NTPase SRP54 PF00448.22 CDW60111.1 - 0.15 11.7 0.5 0.42 10.2 0.1 2.1 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain DnaJ PF00226.31 CDW60112.1 - 2.2e-17 62.9 0.5 9.2e-17 60.9 0.4 2.0 2 0 0 2 2 2 1 DnaJ domain DUF3395 PF11875.8 CDW60112.1 - 3e-12 46.7 0.4 1.3e-11 44.6 0.4 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3395) ANAPC4_WD40 PF12894.7 CDW60113.1 - 9.3e-10 38.7 0.0 0.0019 18.4 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CDW60113.1 - 2.2e-07 31.5 0.5 0.0015 19.3 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 CDW60114.1 - 3e-09 37.4 3.4 2.7e-05 24.8 0.3 3.3 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW60114.1 - 3.7e-06 27.1 0.0 0.0014 18.9 0.0 2.8 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 CDW60114.1 - 0.055 13.2 0.0 0.07 12.9 0.0 1.1 1 0 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Cys_rich_FGFR PF00839.17 CDW60115.1 - 9.9e-113 368.3 74.4 8.8e-15 54.6 2.0 11.2 11 0 0 11 11 11 11 Cysteine rich repeat DNA_Packaging_2 PF11123.8 CDW60115.1 - 0.0012 19.0 0.0 1.7 8.9 0.0 3.1 2 0 0 2 2 2 2 DNA packaging protein ADH_zinc_N PF00107.26 CDW60116.1 - 1.6e-12 47.5 0.0 2.8e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CDW60116.1 - 1.1e-11 45.9 0.0 2.1e-11 45.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW60116.1 - 1.2e-06 28.3 0.0 2.4e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 CDW60116.1 - 0.015 14.6 0.2 0.21 10.9 0.1 2.3 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain AAA_2 PF07724.14 CDW60117.1 - 3.9e-60 202.9 0.3 3.5e-56 190.0 0.0 3.3 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CDW60117.1 - 1.1e-35 121.7 1.2 1.1e-35 121.7 1.2 3.3 2 1 1 3 3 3 1 AAA lid domain AAA PF00004.29 CDW60117.1 - 2.6e-27 95.9 1.5 4.6e-14 53.0 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CDW60117.1 - 4.7e-26 90.6 1.1 2.6e-25 88.3 0.2 2.9 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CDW60117.1 - 7.2e-21 74.6 0.8 9.8e-15 54.8 0.0 4.1 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 CDW60117.1 - 5.8e-16 58.4 0.3 3.9e-07 30.1 0.0 3.7 4 0 0 4 4 3 2 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 CDW60117.1 - 6.6e-13 49.4 3.5 6.1e-06 26.7 0.0 4.5 3 2 1 5 5 4 2 AAA ATPase domain Sigma54_activat PF00158.26 CDW60117.1 - 8.8e-11 41.8 0.0 6.4e-07 29.2 0.0 2.8 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 CDW60117.1 - 1.3e-10 41.7 0.4 0.0028 17.9 0.0 4.9 3 2 0 3 3 3 2 AAA domain AAA_14 PF13173.6 CDW60117.1 - 5.2e-09 36.2 0.0 0.0056 16.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 CDW60117.1 - 1.9e-08 33.9 0.1 2.8e-05 23.6 0.1 3.8 2 1 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 CDW60117.1 - 1.4e-07 31.4 0.0 0.023 14.4 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein RuvB_N PF05496.12 CDW60117.1 - 3.7e-07 30.0 1.2 0.26 11.0 0.0 5.0 3 1 1 4 4 4 2 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 CDW60117.1 - 1.5e-06 28.3 12.1 0.089 12.7 0.1 4.8 3 2 2 5 5 4 3 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CDW60117.1 - 2.5e-06 27.1 0.0 0.019 14.5 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 CDW60117.1 - 6.9e-06 26.1 0.0 0.018 15.0 0.0 3.0 2 2 0 2 2 2 2 NACHT domain Mg_chelatase PF01078.21 CDW60117.1 - 1.6e-05 24.4 0.0 0.49 9.7 0.0 3.7 2 2 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CDW60117.1 - 1.7e-05 25.1 0.0 0.33 11.3 0.0 3.3 3 0 0 3 3 3 2 RNA helicase Roc PF08477.13 CDW60117.1 - 2e-05 24.8 0.0 0.15 12.3 0.0 2.9 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 CDW60117.1 - 4.9e-05 23.9 6.1 0.018 15.6 0.0 3.9 4 1 0 4 4 2 2 AAA domain ResIII PF04851.15 CDW60117.1 - 6.3e-05 23.1 0.4 0.69 9.9 0.0 4.1 2 2 2 4 4 4 1 Type III restriction enzyme, res subunit AAA_28 PF13521.6 CDW60117.1 - 0.00015 22.0 0.0 1.5 9.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 CDW60117.1 - 0.00023 21.3 0.0 0.16 12.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain DNA_pol3_delta2 PF13177.6 CDW60117.1 - 0.00029 20.7 0.0 0.22 11.3 0.0 2.9 2 0 0 2 2 2 1 DNA polymerase III, delta subunit TsaE PF02367.17 CDW60117.1 - 0.00046 20.2 0.0 1.4 9.0 0.0 2.8 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 CDW60117.1 - 0.00049 19.4 0.0 0.094 12.0 0.0 3.0 2 0 0 2 2 2 1 Zeta toxin AAA_3 PF07726.11 CDW60117.1 - 0.00065 19.6 0.0 0.63 9.9 0.0 3.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDW60117.1 - 0.001 18.9 0.2 2.8 7.6 0.0 3.2 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 CDW60117.1 - 0.001 19.0 2.4 1.1 9.2 0.1 3.3 3 1 0 4 4 2 2 RsgA GTPase NTPase_1 PF03266.15 CDW60117.1 - 0.0018 18.2 0.2 2.1 8.2 0.0 3.8 4 0 0 4 4 3 1 NTPase Torsin PF06309.11 CDW60117.1 - 0.0019 18.3 0.0 0.024 14.7 0.0 2.5 2 0 0 2 2 2 1 Torsin AAA_19 PF13245.6 CDW60117.1 - 0.0052 17.1 0.2 0.4 11.0 0.2 3.5 3 1 0 3 3 2 1 AAA domain AAA_30 PF13604.6 CDW60117.1 - 0.015 15.0 0.1 5.9 6.6 0.0 3.6 3 1 0 3 3 3 0 AAA domain DUF87 PF01935.17 CDW60117.1 - 0.019 15.0 7.4 1.8 8.6 0.0 3.9 3 0 0 3 3 3 0 Helicase HerA, central domain DUF4407 PF14362.6 CDW60117.1 - 0.035 13.5 8.6 0.095 12.0 8.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SRP54 PF00448.22 CDW60117.1 - 0.039 13.6 0.6 9.3 5.8 0.0 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 CDW60117.1 - 0.045 13.5 0.0 17 5.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ras PF00071.22 CDW60117.1 - 0.046 13.3 0.0 14 5.2 0.0 3.0 2 0 0 2 2 2 0 Ras family MMR_HSR1 PF01926.23 CDW60117.1 - 0.083 13.0 1.6 25 5.0 0.0 4.0 4 1 0 4 4 3 0 50S ribosome-binding GTPase KTI12 PF08433.10 CDW60117.1 - 0.098 12.1 5.5 10 5.5 0.0 4.2 4 1 1 5 5 4 0 Chromatin associated protein KTI12 AAA_17 PF13207.6 CDW60117.1 - 0.29 11.5 6.3 24 5.3 0.0 4.6 4 0 0 4 4 3 0 AAA domain ABC_tran PF00005.27 CDW60117.1 - 0.53 10.8 12.2 0.54 10.8 0.0 4.5 4 2 0 4 4 2 0 ABC transporter Atg14 PF10186.9 CDW60117.1 - 0.68 9.0 9.9 1.8 7.6 9.9 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_23 PF13476.6 CDW60117.1 - 1 9.9 0.0 0.088 13.3 1.5 4.7 2 1 2 4 4 2 0 AAA domain Exonuc_VII_L PF02601.15 CDW60117.1 - 9 5.8 10.7 1.1 8.7 5.9 2.0 2 0 0 2 2 2 0 Exonuclease VII, large subunit Glucosaminidase PF01832.20 CDW60118.1 - 1.2e-19 70.6 2.0 1.2e-19 70.6 2.0 1.7 2 0 0 2 2 2 1 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase LysM PF01476.20 CDW60118.1 - 1.2e-13 50.8 0.1 2.8e-13 49.7 0.1 1.7 2 0 0 2 2 2 1 LysM domain PALP PF00291.25 CDW60119.1 - 1.9e-70 237.6 0.2 2.1e-70 237.5 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme OAM_dimer PF16554.5 CDW60119.1 - 0.011 16.2 0.2 5.9 7.4 0.0 3.2 3 0 0 3 3 3 0 Dimerisation domain of d-ornithine 4,5-aminomutase GHMP_kinases_C PF08544.13 CDW60119.1 - 0.032 14.6 0.0 14 6.2 0.0 2.5 2 0 0 2 2 2 0 GHMP kinases C terminal DUF2188 PF09954.9 CDW60119.1 - 0.069 13.3 0.5 23 5.2 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2188) DJ-1_PfpI PF01965.24 CDW60119.1 - 0.086 12.6 0.1 4.8 7.0 0.0 2.4 2 0 0 2 2 2 0 DJ-1/PfpI family ADH_zinc_N PF00107.26 CDW60119.1 - 0.1 12.6 0.9 0.67 9.9 0.5 2.4 2 1 0 2 2 2 0 Zinc-binding dehydrogenase FUR PF01475.19 CDW60120.1 - 3.3e-36 124.1 0.0 4e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Ferric uptake regulator family Cytochrom_C550 PF14495.6 CDW60120.1 - 0.012 15.3 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c-550 domain DUF4817 PF16087.5 CDW60120.1 - 0.022 14.6 0.0 0.041 13.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) TF_Zn_Ribbon PF08271.12 CDW60120.1 - 0.04 13.4 0.3 0.71 9.4 0.0 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding Type2_restr_D3 PF16902.5 CDW60120.1 - 0.054 13.4 0.0 0.14 12.1 0.0 1.6 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain Trans_reg_C PF00486.28 CDW60120.1 - 0.089 12.9 0.0 0.2 11.7 0.0 1.6 1 1 0 1 1 1 0 Transcriptional regulatory protein, C terminal HTH_11 PF08279.12 CDW60120.1 - 0.1 12.5 0.0 8.4 6.4 0.0 2.8 1 1 1 2 2 2 0 HTH domain PALP PF00291.25 CDW60121.1 - 2e-83 280.2 6.1 5.5e-81 272.2 4.4 2.1 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme AlaDh_PNT_C PF01262.21 CDW60121.1 - 1.7e-71 239.9 0.7 1.7e-71 239.9 0.7 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CDW60121.1 - 1.7e-35 122.3 0.0 3.9e-35 121.1 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Shikimate_DH PF01488.20 CDW60121.1 - 2e-07 31.1 0.1 2e-07 31.1 0.1 2.3 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CDW60121.1 - 2.3e-06 27.1 0.8 4.5e-06 26.2 0.1 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 CDW60121.1 - 0.0003 20.2 0.6 0.0003 20.2 0.6 2.4 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Methyltransf_25 PF13649.6 CDW60121.1 - 0.0013 19.4 0.0 0.01 16.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Phage_holin_3_6 PF07332.11 CDW60121.1 - 0.0049 16.9 1.5 0.012 15.7 1.5 1.6 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III TrkA_N PF02254.18 CDW60121.1 - 0.0099 16.1 0.6 0.044 14.0 0.6 2.2 1 0 0 1 1 1 1 TrkA-N domain Methyltransf_11 PF08241.12 CDW60121.1 - 0.01 16.4 0.0 0.061 14.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain XdhC_C PF13478.6 CDW60121.1 - 0.058 13.9 0.1 0.82 10.2 0.0 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain Pyr_redox PF00070.27 CDW60121.1 - 0.07 13.7 0.4 0.07 13.7 0.4 3.5 5 0 0 5 5 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CDW60121.1 - 3.4 8.2 5.4 1.2 9.7 0.2 2.8 2 1 1 3 3 3 0 Putative NAD(P)-binding Xan_ur_permease PF00860.20 CDW60122.1 - 2.2e-105 352.6 38.2 3e-105 352.1 38.2 1.2 1 0 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 CDW60122.1 - 0.0032 17.9 1.9 0.0032 17.9 1.9 3.5 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily Flavi_NS2B PF01002.19 CDW60122.1 - 0.33 10.8 2.9 1.5 8.7 0.3 2.6 2 0 0 2 2 2 0 Flavivirus non-structural protein NS2B Kringle PF00051.18 CDW60123.1 - 1.5e-08 34.8 4.0 1.5e-08 34.8 4.0 4.8 6 0 0 6 6 6 2 Kringle domain DUF1308 PF07000.11 CDW60124.1 - 1.7e-33 115.9 0.0 2.9e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) DUF5614 PF18474.1 CDW60124.1 - 4.4e-15 55.6 3.0 2.5e-13 49.8 0.6 2.5 2 1 0 2 2 2 1 Family of unknown function (DUF5614) Anticodon_1 PF08264.13 CDW60125.1 - 8.5e-17 61.5 0.0 2.2e-16 60.2 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDW60125.1 - 3.3e-10 39.3 0.1 5.6e-10 38.5 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CDW60125.1 - 2.7e-08 33.5 0.1 5.1e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 CDW60125.1 - 7.7e-07 27.7 0.2 1.7e-06 26.6 0.2 1.6 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Thioredoxin PF00085.20 CDW60126.1 - 9.5e-25 86.6 0.0 1.2e-24 86.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDW60126.1 - 1.7e-07 31.7 0.0 6e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CDW60126.1 - 5.6e-05 23.2 0.0 9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 CDW60126.1 - 0.00033 20.9 0.0 0.092 13.1 0.0 2.5 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.6 CDW60126.1 - 0.00034 20.6 0.0 0.00054 20.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain HyaE PF07449.11 CDW60126.1 - 0.09 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 CDW60126.1 - 0.19 11.5 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin SHS2_Rpb7-N PF03876.17 CDW60127.1 - 0.00045 20.5 0.0 0.00088 19.6 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 JAB PF01398.21 CDW60128.1 - 4.9e-31 107.1 0.0 9.4e-31 106.2 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDW60128.1 - 2.5e-08 34.3 0.5 4.8e-08 33.4 0.5 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 CDW60128.1 - 4e-06 26.6 0.0 6.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UQ_con PF00179.26 CDW60129.1 - 1.9e-48 163.6 0.0 2.6e-48 163.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme HARE-HTH PF05066.13 CDW60129.1 - 0.15 12.4 0.0 0.25 11.8 0.0 1.3 1 0 0 1 1 1 0 HB1, ASXL, restriction endonuclease HTH domain ParA PF10609.9 CDW60130.1 - 3e-91 305.2 0.0 3.4e-91 305.1 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CDW60130.1 - 2.6e-12 46.9 0.0 3.1e-11 43.4 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CDW60130.1 - 6.6e-06 25.5 0.3 3.2e-05 23.3 0.1 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.6 CDW60130.1 - 1.2e-05 25.3 0.5 0.00017 21.5 0.5 2.1 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CDW60130.1 - 0.0024 17.5 0.1 0.0044 16.6 0.1 1.3 1 0 0 1 1 1 1 AAA domain MipZ PF09140.11 CDW60130.1 - 0.0026 17.1 0.0 0.0053 16.1 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ NB-ARC PF00931.22 CDW60130.1 - 0.0027 16.9 0.1 0.0054 16.0 0.1 1.5 1 0 0 1 1 1 1 NB-ARC domain Zeta_toxin PF06414.12 CDW60130.1 - 0.0039 16.5 0.0 0.0074 15.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 CDW60130.1 - 0.0075 16.7 0.0 0.0091 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_26 PF13500.6 CDW60130.1 - 0.0096 15.8 0.1 0.19 11.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain CBP_BcsQ PF06564.12 CDW60130.1 - 0.021 14.3 0.0 0.047 13.2 0.0 1.6 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 CDW60130.1 - 0.027 14.4 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 CDW60130.1 - 0.064 13.2 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 CDW60130.1 - 0.069 13.5 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 CDW60130.1 - 0.094 13.0 0.1 0.25 11.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CDW60130.1 - 0.13 12.8 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDW60130.1 - 0.14 12.1 0.3 0.31 10.9 0.3 1.5 1 0 0 1 1 1 0 NACHT domain MeaB PF03308.16 CDW60130.1 - 0.19 10.7 0.1 0.28 10.1 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 CDW60130.1 - 0.24 11.0 0.2 0.38 10.4 0.2 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain RecR PF02132.15 CDW60130.1 - 1.6 8.3 4.4 25 4.6 0.0 2.5 2 0 0 2 2 2 0 RecR protein Ribosomal_L27A PF00828.19 CDW60131.1 - 1.1e-21 77.8 0.0 1.5e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF5026 PF16429.5 CDW60131.1 - 0.2 11.8 0.6 0.42 10.7 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5026) Consortin_C PF15281.6 CDW60132.1 - 0.25 11.3 0.7 0.51 10.4 0.1 1.7 2 0 0 2 2 2 0 Consortin C-terminus zf-RING_2 PF13639.6 CDW60133.1 - 7.7e-12 45.3 9.5 1.9e-11 44.1 9.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW60133.1 - 4.8e-10 39.1 7.5 1.2e-09 37.8 7.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CDW60133.1 - 1.6e-09 37.9 10.4 8.9e-09 35.5 10.4 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CDW60133.1 - 5.6e-09 35.7 6.9 1.2e-08 34.6 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CDW60133.1 - 1.5e-08 34.5 6.6 4.2e-08 33.0 6.6 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CDW60133.1 - 3.3e-07 30.2 4.0 3.5e-06 26.9 2.4 2.6 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CDW60133.1 - 3.3e-06 26.9 4.6 9.6e-06 25.4 4.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CDW60133.1 - 7.9e-05 22.4 7.1 0.00023 20.9 7.1 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CDW60133.1 - 8.2e-05 22.6 6.3 0.00076 19.5 6.3 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 CDW60133.1 - 0.00012 21.8 7.2 0.00012 21.8 7.2 2.8 2 0 0 2 2 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 CDW60133.1 - 0.0004 20.0 5.7 0.0012 18.4 5.7 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 CDW60133.1 - 0.0025 17.6 1.7 0.0055 16.5 1.7 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-P11 PF03854.14 CDW60133.1 - 0.052 13.2 7.4 0.33 10.7 7.4 2.3 1 1 0 1 1 1 0 P-11 zinc finger FANCL_C PF11793.8 CDW60133.1 - 0.13 12.5 7.8 1.5 9.1 7.8 2.6 1 1 0 1 1 1 0 FANCL C-terminal domain Endonuclease_7 PF02945.15 CDW60133.1 - 0.14 12.1 2.2 0.22 11.4 2.2 1.3 1 0 0 1 1 1 0 Recombination endonuclease VII zf-C3H2C3 PF17122.5 CDW60133.1 - 0.17 12.0 6.0 0.73 9.9 6.0 2.3 1 0 0 1 1 1 0 Zinc-finger Cytochrom_B_C PF00032.17 CDW60133.1 - 0.58 10.5 3.5 8 6.8 3.4 2.5 1 1 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD RINGv PF12906.7 CDW60133.1 - 0.6 10.3 6.7 1.7 8.9 6.7 1.8 1 1 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 CDW60133.1 - 1.1 9.5 5.8 0.36 11.0 1.1 2.4 2 1 1 3 3 2 0 KIAA1045 RING finger zf-RING-like PF08746.11 CDW60133.1 - 1.7 9.0 7.7 3.8 7.9 7.7 1.6 1 0 0 1 1 1 0 RING-like domain zf-Di19 PF05605.12 CDW60133.1 - 4.1 7.8 8.3 43 4.5 7.0 2.9 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Peptidase_M13_N PF05649.13 CDW60134.1 - 1.7e-61 209.0 0.0 3.1e-61 208.2 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CDW60134.1 - 2.9e-56 190.3 0.1 6.4e-56 189.2 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M13 Rab3-GTPase_cat PF13890.6 CDW60135.1 - 3.3e-31 108.1 0.0 6.3e-31 107.2 0.0 1.4 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit HEAT PF02985.22 CDW60136.1 - 2.4e-10 39.8 5.8 0.03 14.6 0.1 6.3 6 0 0 6 6 6 4 HEAT repeat HEAT_2 PF13646.6 CDW60136.1 - 0.012 15.9 0.0 12 6.4 0.0 3.6 3 1 1 4 4 4 0 HEAT repeats Cnd1 PF12717.7 CDW60136.1 - 0.02 14.9 0.9 2.5 8.1 0.1 2.9 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 TPR_14 PF13428.6 CDW60137.1 - 1.1e-05 25.9 0.0 0.3 12.0 0.0 3.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW60137.1 - 0.00021 21.7 0.3 0.91 10.3 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDW60137.1 - 0.0012 18.8 0.0 0.2 11.8 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW60137.1 - 0.0028 17.3 0.0 0.091 12.5 0.0 3.1 4 0 0 4 4 4 1 TPR repeat Fis1_TPR_C PF14853.6 CDW60137.1 - 0.003 17.6 0.1 0.38 10.9 0.0 2.5 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 CDW60137.1 - 0.0071 16.8 0.0 0.92 10.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW60137.1 - 0.015 15.6 0.0 0.19 12.2 0.0 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDW60137.1 - 0.05 14.3 0.2 0.35 11.5 0.1 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW60137.1 - 0.1 12.9 0.1 50 4.5 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Coatomer_E PF04733.14 CDW60137.1 - 0.16 11.4 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Coatomer epsilon subunit SAP18 PF06487.12 CDW60139.1 - 3e-38 131.1 0.0 3.9e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) DnaJ PF00226.31 CDW60140.1 - 2.1e-20 72.6 1.2 3.1e-20 72.1 1.2 1.3 1 0 0 1 1 1 1 DnaJ domain DUF4390 PF14334.6 CDW60140.1 - 0.061 12.8 0.1 0.1 12.0 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4390) Vac_Fusion PF02346.16 CDW60140.1 - 0.062 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 zf-U1 PF06220.12 CDW60140.1 - 0.072 12.9 0.5 0.14 12.0 0.5 1.5 1 0 0 1 1 1 0 U1 zinc finger CcdB PF01845.17 CDW60143.1 - 3.8e-28 97.6 0.0 4.2e-28 97.5 0.0 1.0 1 0 0 1 1 1 1 CcdB protein NEL PF14496.6 CDW60144.1 - 1.7e-72 243.5 8.8 2.7e-72 242.8 8.8 1.3 1 0 0 1 1 1 1 C-terminal novel E3 ligase, LRR-interacting phage_tail_N PF08400.10 CDW60145.1 - 2.5e-48 163.5 0.5 2.5e-48 163.5 0.5 2.5 2 1 0 2 2 2 1 Prophage tail fibre N-terminal DUF4376 PF14301.6 CDW60145.1 - 1.3e-27 96.2 1.4 1.3e-27 96.2 1.4 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4376) CarboxypepD_reg PF13620.6 CDW60145.1 - 5.5e-08 33.0 1.8 1e-07 32.1 0.0 2.4 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain MMPL PF03176.15 CDW60145.1 - 9.4 5.0 14.0 17 4.2 14.0 1.3 1 0 0 1 1 1 0 MMPL family Ail_Lom PF06316.11 CDW60146.1 - 1.3e-128 426.4 3.9 1.5e-128 426.3 3.9 1.0 1 0 0 1 1 1 1 Enterobacterial Ail/Lom protein OMP_b-brl PF13505.6 CDW60146.1 - 8.6e-23 81.4 3.6 1e-22 81.1 3.6 1.0 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OmpA_membrane PF01389.17 CDW60146.1 - 0.00086 19.1 0.1 0.0014 18.4 0.1 1.3 1 0 0 1 1 1 1 OmpA-like transmembrane domain Phage-tail_3 PF13550.6 CDW60147.1 - 2.4e-39 134.8 0.0 4.5e-39 133.9 0.0 1.5 1 0 0 1 1 1 1 Putative phage tail protein DUF3672 PF12421.8 CDW60147.1 - 1.2e-37 128.8 0.1 2.6e-37 127.7 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III protein DUF1983 PF09327.11 CDW60147.1 - 2.2e-22 78.9 1.5 6.5e-22 77.4 1.5 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1983) fn3 PF00041.21 CDW60147.1 - 1.8e-07 31.4 0.3 0.0022 18.3 0.0 3.6 3 0 0 3 3 3 2 Fibronectin type III domain Y_Y_Y PF07495.13 CDW60147.1 - 0.0017 18.2 0.0 0.015 15.2 0.0 2.5 2 0 0 2 2 2 1 Y_Y_Y domain CarboxypepD_reg PF13620.6 CDW60147.1 - 0.051 13.8 0.4 0.051 13.8 0.4 3.3 5 0 0 5 5 5 0 Carboxypeptidase regulatory-like domain Bactofilin PF04519.13 CDW60147.1 - 0.074 13.4 0.8 0.23 11.7 0.1 2.2 2 0 0 2 2 2 0 Polymer-forming cytoskeletal Phage_tail_L PF05100.12 CDW60148.1 - 3.3e-90 300.9 0.1 4.9e-90 300.4 0.1 1.2 1 0 0 1 1 1 1 Phage minor tail protein L Lambda_tail_I PF06805.12 CDW60148.1 - 5.9e-28 97.0 0.0 1.5e-27 95.8 0.0 1.7 1 0 0 1 1 1 1 Bacteriophage lambda tail assembly protein I Phage_min_tail PF05939.13 CDW60148.1 - 1.9e-23 82.9 0.0 4.4e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 Phage minor tail protein Prok-JAB PF14464.6 CDW60148.1 - 3.7e-13 49.3 0.1 9.6e-13 48.0 0.1 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain NLPC_P60 PF00877.19 CDW60148.1 - 7.4e-07 29.2 0.0 1.4e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 NlpC/P60 family Tape_meas_lam_C PF09718.10 CDW60149.1 - 1.8e-24 85.7 8.8 7.4e-24 83.7 8.8 2.2 1 0 0 1 1 1 1 Lambda phage tail tape-measure protein (Tape_meas_lam_C) TPR_7 PF13176.6 CDW60149.1 - 2.8 8.2 8.3 3 8.1 0.2 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat GWT1 PF06423.12 CDW60150.1 - 2.9e-19 69.7 5.8 2.9e-19 69.7 5.8 1.6 2 0 0 2 2 2 1 GWT1 SusD-like_3 PF14322.6 CDW60150.1 - 0.088 13.1 0.7 2.5 8.4 0.1 2.1 2 0 0 2 2 2 0 Starch-binding associating with outer membrane NIDO PF06119.14 CDW60151.1 - 9e-08 33.0 0.0 1.7e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Nidogen-like TIG PF01833.24 CDW60151.1 - 0.0033 17.4 0.0 0.0055 16.8 0.0 1.4 1 0 0 1 1 1 1 IPT/TIG domain Patatin PF01734.22 CDW60152.1 - 1.8e-17 64.2 0.4 1e-16 61.7 0.4 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase FUSC_2 PF13515.6 CDW60152.1 - 0.13 12.4 0.4 0.26 11.4 0.4 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein-like Ras PF00071.22 CDW60153.1 - 1.3e-33 115.9 0.2 1.9e-15 56.8 0.3 3.0 1 1 1 2 2 2 2 Ras family Roc PF08477.13 CDW60153.1 - 9.2e-11 42.0 0.0 3.3e-09 37.0 0.0 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CDW60153.1 - 0.0012 18.9 0.0 0.0024 17.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CDW60153.1 - 0.0057 16.1 0.0 0.85 9.0 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_14 PF13173.6 CDW60153.1 - 0.021 14.8 0.0 0.038 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDW60153.1 - 0.11 12.4 0.0 2 8.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cNMP_binding PF00027.29 CDW60154.1 - 7.2e-45 151.0 0.1 2.3e-23 82.1 0.0 2.1 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Cupin_3 PF05899.12 CDW60154.1 - 0.093 12.4 0.3 0.32 10.7 0.2 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF861) Cupin_2 PF07883.11 CDW60154.1 - 0.099 12.4 0.2 0.82 9.4 0.0 2.1 2 0 0 2 2 2 0 Cupin domain Hist_deacetyl PF00850.19 CDW60155.1 - 3.4e-23 82.6 1.4 4.1e-23 82.3 1.4 1.0 1 0 0 1 1 1 1 Histone deacetylase domain dsrm PF00035.26 CDW60157.1 - 0.00037 21.1 0.0 0.0069 17.1 0.1 2.3 2 0 0 2 2 2 1 Double-stranded RNA binding motif LPP20 PF02169.16 CDW60157.1 - 0.1 13.0 0.1 0.42 11.0 0.0 2.0 1 1 1 2 2 2 0 LPP20 lipoprotein GOLGA2L5 PF15070.6 CDW60158.1 - 6e-36 124.3 38.4 2.2e-27 96.0 5.0 3.8 2 1 2 4 4 4 2 Putative golgin subfamily A member 2-like protein 5 DUF3658 PF12395.8 CDW60158.1 - 0.84 9.6 8.4 0.054 13.4 1.2 2.9 3 1 0 3 3 3 0 Protein of unknown function Proton_antipo_M PF00361.20 CDW60161.1 - 2.8e-08 33.3 7.9 4.4e-08 32.7 7.9 1.3 1 0 0 1 1 1 1 Proton-conducting membrane transporter RT_RNaseH PF17917.1 CDW60163.1 - 0.015 15.6 0.1 0.71 10.2 0.0 2.2 1 1 1 2 2 2 0 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDW60163.1 - 0.1 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase DUF3640 PF12342.8 CDW60163.1 - 0.17 11.7 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3640) CTNNBL PF08216.11 CDW60164.1 - 1.8e-34 118.0 1.2 5.2e-34 116.5 1.2 1.8 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm PF00514.23 CDW60164.1 - 0.0013 18.7 2.0 0.058 13.5 0.1 3.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Methyltransf_12 PF08242.12 CDW60164.1 - 0.032 14.9 0.4 0.14 13.0 0.4 2.1 1 0 0 1 1 1 0 Methyltransferase domain DUF4330 PF14221.6 CDW60165.1 - 0.13 12.5 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) PHD PF00628.29 CDW60167.1 - 0.00014 21.6 0.9 0.00025 20.9 0.9 1.4 1 0 0 1 1 1 1 PHD-finger DUF2318 PF10080.9 CDW60167.1 - 0.0061 16.6 0.4 0.015 15.4 0.4 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2318) C1_1 PF00130.22 CDW60167.1 - 0.012 15.5 0.9 0.02 14.7 0.9 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 CDW60167.1 - 0.047 13.6 1.7 0.089 12.7 1.7 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Cation_ATPase_N PF00690.26 CDW60169.1 - 4.6e-21 74.3 1.4 5.9e-20 70.7 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus E1-E2_ATPase PF00122.20 CDW60169.1 - 2.9e-05 23.7 2.1 0.018 14.6 0.1 2.1 2 0 0 2 2 2 2 E1-E2 ATPase MgtE PF01769.16 CDW60169.1 - 0.059 13.8 0.0 0.09 13.2 0.0 1.3 1 0 0 1 1 1 0 Divalent cation transporter BacA PF02673.18 CDW60169.1 - 0.066 12.9 0.0 0.075 12.7 0.0 1.1 1 0 0 1 1 1 0 Bacitracin resistance protein BacA M20_dimer PF07687.14 CDW60170.1 - 4.5e-18 65.2 0.1 8.6e-18 64.2 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CDW60170.1 - 1.2e-16 61.1 0.6 1.7e-16 60.6 0.6 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 CDW60170.1 - 3e-13 49.5 0.7 7.3e-07 28.5 0.1 3.0 2 1 1 3 3 3 2 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.17 CDW60170.1 - 1.3e-11 44.5 0.4 1.5e-10 41.1 0.4 2.3 1 1 0 1 1 1 1 Peptidase family M28 Lon_C PF05362.13 CDW60171.1 - 1.6e-08 34.3 1.2 6.7e-07 29.0 0.0 2.4 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain MadM PF03818.13 CDW60171.1 - 0.00057 19.7 0.9 0.00057 19.7 0.9 2.3 3 0 0 3 3 3 1 Malonate/sodium symporter MadM subunit PDZ_6 PF17820.1 CDW60171.1 - 0.0063 16.3 0.0 0.033 14.0 0.0 2.2 2 0 0 2 2 2 1 PDZ domain Bul1_C PF04426.12 CDW60171.1 - 0.086 12.2 1.7 0.15 11.4 1.7 1.3 1 0 0 1 1 1 0 Bul1 C terminus PDZ PF00595.24 CDW60171.1 - 0.11 12.9 0.0 0.31 11.4 0.0 1.8 1 0 0 1 1 1 0 PDZ domain Ldh_1_N PF00056.23 CDW60172.1 - 2.1e-36 125.1 1.0 4e-36 124.2 1.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 CDW60172.1 - 1.8e-25 89.8 0.0 3.6e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain YitT_membrane PF02588.15 CDW60172.1 - 6.9e-25 87.6 6.9 8.9e-22 77.5 2.9 2.4 1 1 1 2 2 2 2 Uncharacterised 5xTM membrane BCR, YitT family COG1284 DUF2179 PF10035.9 CDW60172.1 - 2e-17 62.6 0.1 4.8e-17 61.4 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2179) UDPG_MGDP_dh_N PF03721.14 CDW60172.1 - 0.00099 18.7 1.9 0.0035 16.9 1.9 1.8 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 CDW60172.1 - 0.12 12.7 0.5 0.31 11.3 0.5 1.8 1 1 0 1 1 1 0 TrkA-N domain ThiF PF00899.21 CDW60172.1 - 0.14 11.5 0.3 0.28 10.5 0.3 1.4 1 0 0 1 1 1 0 ThiF family DDE_Tnp_ISL3 PF01610.17 CDW60173.1 - 1.5e-54 185.3 3.2 2.3e-54 184.7 3.2 1.3 1 0 0 1 1 1 1 Transposase zf-ISL3 PF14690.6 CDW60173.1 - 4.8e-10 39.9 3.6 1.5e-09 38.4 3.6 1.9 1 0 0 1 1 1 1 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 HTH_Tnp_ISL3 PF13542.6 CDW60173.1 - 1.6e-05 24.2 0.0 4.1e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 DDE_Tnp_IS240 PF13610.6 CDW60173.1 - 6.1e-05 23.3 3.2 0.12 12.6 1.5 2.4 2 0 0 2 2 2 2 DDE domain HTH_23 PF13384.6 CDW60173.1 - 0.0045 16.7 0.0 0.02 14.7 0.0 2.1 2 0 0 2 2 2 1 Homeodomain-like domain Pribosyl_synth PF14572.6 CDW60175.1 - 5.4e-56 189.5 0.5 1.1e-45 156.0 0.3 2.5 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 CDW60175.1 - 5.1e-33 113.5 0.5 1.2e-32 112.3 0.2 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase SWC7 PF17330.2 CDW60175.1 - 0.002 18.2 0.2 0.33 11.0 0.0 2.5 2 0 0 2 2 2 2 SWR1 chromatin-remodelling complex, sub-unit Swc7 Pkinase_Tyr PF07714.17 CDW60176.1 - 1.4e-79 267.0 0.1 1.1e-74 251.0 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.25 CDW60176.1 - 1.1e-33 116.8 0.6 2.6e-22 79.4 0.0 3.2 3 0 0 3 3 3 2 Protein kinase domain Ig_3 PF13927.6 CDW60176.1 - 1.3e-25 89.7 3.2 4.2e-10 40.1 0.0 5.6 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 CDW60176.1 - 2.2e-22 78.9 0.7 8.3e-12 45.0 0.0 4.8 5 0 0 5 5 5 3 Immunoglobulin I-set domain Ig_2 PF13895.6 CDW60176.1 - 1.3e-15 57.5 9.7 9.5e-08 32.3 0.0 5.4 5 1 0 5 5 5 2 Immunoglobulin domain ig PF00047.25 CDW60176.1 - 2.7e-14 53.1 2.6 1.9e-05 24.8 0.0 5.3 5 0 0 5 5 5 3 Immunoglobulin domain V-set PF07686.17 CDW60176.1 - 4.2e-10 39.8 3.1 0.0016 18.6 0.2 4.7 4 1 0 5 5 5 2 Immunoglobulin V-set domain Ig_6 PF18452.1 CDW60176.1 - 3.9e-07 29.5 0.1 0.87 9.2 0.0 4.4 4 0 0 4 4 4 3 Immunoglobulin domain Kinase-like PF14531.6 CDW60176.1 - 0.00037 19.9 0.0 0.00064 19.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Ig_4 PF16680.5 CDW60176.1 - 0.0027 17.9 0.7 5.3 7.4 0.0 4.3 5 1 1 6 6 6 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 CDW60176.1 - 0.039 14.0 0.6 2.3 8.4 0.0 3.6 4 0 0 4 4 4 0 Izumo-like Immunoglobulin domain DNA_pol_B_3 PF08408.10 CDW60176.1 - 0.073 13.3 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase family B viral insert Hydrolase_3 PF08282.12 CDW60177.1 - 4.8e-56 190.3 0.0 6.8e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase EamA PF00892.20 CDW60177.1 - 6.3e-13 49.1 33.2 5e-07 30.0 18.2 2.2 2 0 0 2 2 2 2 EamA-like transporter family S6PP PF05116.13 CDW60177.1 - 7.2e-12 45.4 0.0 2e-07 30.8 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase_4 PF12146.8 CDW60177.1 - 2.4e-11 43.4 0.0 3.8e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Hydrolase PF00702.26 CDW60177.1 - 2.7e-08 34.3 0.0 3.6e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Abhydrolase_1 PF00561.20 CDW60177.1 - 3.9e-06 26.7 0.0 6.6e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold HAD PF12710.7 CDW60177.1 - 0.013 16.0 0.1 0.074 13.4 0.0 2.3 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW60177.1 - 0.04 14.0 0.1 0.17 12.0 0.0 2.1 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase LysR_substrate PF03466.20 CDW60178.1 - 1e-43 149.1 1.5 1.5e-43 148.6 1.5 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDW60178.1 - 3.4e-16 58.9 2.2 4e-16 58.7 1.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_30 PF13556.6 CDW60178.1 - 0.091 12.6 0.5 0.2 11.5 0.5 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Meth_synt_2 PF01717.18 CDW60179.1 - 3.2e-171 568.9 0.0 4.3e-163 542.2 0.0 2.5 3 0 0 3 3 3 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CDW60179.1 - 3.1e-134 447.4 0.0 2.7e-125 418.0 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain DLH PF01738.18 CDW60180.1 - 5.3e-79 264.8 0.0 6.1e-79 264.6 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 CDW60180.1 - 1.5e-07 31.6 0.1 0.0001 22.3 0.2 2.8 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 CDW60180.1 - 3e-06 26.8 0.0 0.0001 21.9 0.0 2.1 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CDW60180.1 - 5.7e-06 26.2 0.0 0.0058 16.3 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDW60180.1 - 0.00018 20.9 0.0 0.32 10.2 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CDW60180.1 - 0.00035 20.4 0.0 0.00055 19.8 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 CDW60180.1 - 0.019 15.0 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein AP_endonuc_2 PF01261.24 CDW60180.1 - 0.081 12.4 0.0 0.18 11.2 0.0 1.8 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Abhydrolase_5 PF12695.7 CDW60180.1 - 0.11 12.3 0.0 0.33 10.7 0.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family PNP_UDP_1 PF01048.20 CDW60181.1 - 8.1e-41 139.8 1.5 9.1e-41 139.6 1.5 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Ubie_methyltran PF01209.18 CDW60182.1 - 1.7e-113 377.7 0.0 2e-113 377.5 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CDW60182.1 - 8.3e-25 87.3 0.0 2e-24 86.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW60182.1 - 1.1e-22 80.5 0.0 2.5e-22 79.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CDW60182.1 - 2.2e-20 73.0 0.0 3.9e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW60182.1 - 1.2e-17 64.2 0.0 1.5e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW60182.1 - 9.6e-14 51.9 0.0 2.4e-13 50.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CDW60182.1 - 7e-07 29.2 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RmuC PF02646.16 CDW60182.1 - 1.9e-06 27.2 0.4 9.7e-06 24.9 0.4 1.9 1 1 0 1 1 1 1 RmuC family UPF0020 PF01170.18 CDW60182.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 CDW60182.1 - 0.00017 21.2 0.0 0.00052 19.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Rsm22 PF09243.10 CDW60182.1 - 0.0042 16.4 0.0 0.031 13.5 0.0 2.0 1 1 1 2 2 2 1 Mitochondrial small ribosomal subunit Rsm22 RrnaAD PF00398.20 CDW60182.1 - 0.0072 15.4 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltr_RsmB-F PF01189.17 CDW60182.1 - 0.0088 15.7 0.0 0.029 14.0 0.0 1.8 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltransf_8 PF05148.15 CDW60182.1 - 0.011 15.5 0.0 0.031 14.1 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase MetW PF07021.12 CDW60182.1 - 0.018 14.6 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DREV PF05219.12 CDW60182.1 - 0.022 13.9 0.0 0.038 13.1 0.0 1.4 1 1 0 1 1 1 0 DREV methyltransferase GCD14 PF08704.10 CDW60182.1 - 0.044 13.4 0.0 0.17 11.5 0.0 1.9 1 1 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit NNMT_PNMT_TEMT PF01234.17 CDW60182.1 - 0.14 11.3 0.0 1.2 8.3 0.0 2.1 1 1 0 2 2 2 0 NNMT/PNMT/TEMT family ABC1 PF03109.16 CDW60183.1 - 6.7e-35 119.8 0.0 1.4e-34 118.8 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Glyco_transf_10 PF00852.19 CDW60184.1 - 3.2e-52 176.8 0.6 4.9e-52 176.2 0.6 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 CDW60184.1 - 2.3e-20 73.1 0.5 4.5e-20 72.1 0.1 1.7 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal LicD PF04991.13 CDW60185.1 - 0.00018 21.7 0.1 0.013 15.6 0.2 2.3 1 1 0 2 2 2 2 LicD family gag-asp_proteas PF13975.6 CDW60186.1 - 1e-07 32.4 0.0 2.6e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW60186.1 - 8.2e-07 29.6 0.0 3.9e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 Aspartyl protease PNMA PF14893.6 CDW60186.1 - 0.0049 16.3 0.0 0.0081 15.6 0.0 1.3 1 1 0 1 1 1 1 PNMA FlgN PF05130.12 CDW60186.1 - 0.017 15.7 2.8 0.039 14.5 2.8 1.5 1 0 0 1 1 1 0 FlgN protein Thioredoxin_5 PF13743.6 CDW60186.1 - 0.045 13.4 0.1 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin Cor1 PF04803.12 CDW60186.1 - 0.06 13.6 2.6 0.15 12.3 1.2 2.0 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region RVP PF00077.20 CDW60186.1 - 0.086 13.2 0.1 0.22 11.9 0.1 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Sec34 PF04136.15 CDW60186.1 - 0.22 11.4 4.7 0.11 12.4 2.5 1.6 2 0 0 2 2 2 0 Sec34-like family Myc_target_1 PF15179.6 CDW60187.1 - 0.0072 16.2 0.3 0.01 15.7 0.3 1.3 1 0 0 1 1 1 1 Myc target protein 1 FixP_N PF14715.6 CDW60188.1 - 0.003 17.3 1.4 0.0048 16.6 1.4 1.3 1 0 0 1 1 1 1 N-terminal domain of cytochrome oxidase-cbb3, FixP TruB_N PF01509.18 CDW60189.1 - 0.038 14.4 0.1 0.048 14.0 0.1 1.2 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) RNA_GG_bind PF10258.9 CDW60189.1 - 0.099 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 PHAX RNA-binding domain EAL PF00563.20 CDW60190.1 - 3.5e-64 216.6 0.0 4.7e-64 216.2 0.0 1.2 1 0 0 1 1 1 1 EAL domain CSS-motif PF12792.7 CDW60190.1 - 1.1e-26 93.6 0.0 2.7e-26 92.4 0.0 1.5 2 0 0 2 2 2 1 CSS motif domain associated with EAL OppC_N PF12911.7 CDW60190.1 - 0.96 9.5 5.2 2.9 7.9 0.5 2.5 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C EAL PF00563.20 CDW60191.1 - 4.1e-48 164.0 0.1 8.7e-48 162.9 0.1 1.5 1 0 0 1 1 1 1 EAL domain MerR_1 PF13411.6 CDW60191.1 - 3.6e-17 62.2 0.0 7.7e-17 61.1 0.0 1.6 1 0 0 1 1 1 1 MerR HTH family regulatory protein BLUF PF04940.12 CDW60191.1 - 7.4e-17 61.3 0.0 1.4e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Sensors of blue-light using FAD MerR PF00376.23 CDW60191.1 - 9.2e-13 47.7 0.0 1.7e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 MerR family regulatory protein HTH_17 PF12728.7 CDW60191.1 - 0.00051 20.2 0.1 0.0012 19.0 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CDW60191.1 - 0.011 16.1 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.6 CDW60191.1 - 0.013 15.3 0.0 0.072 12.9 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain MerR_2 PF13591.6 CDW60191.1 - 0.02 14.7 0.1 0.08 12.8 0.0 2.1 2 0 0 2 2 2 0 MerR HTH family regulatory protein HTH_28 PF13518.6 CDW60191.1 - 0.05 13.7 0.0 0.2 11.8 0.0 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain DUF3927 PF13064.6 CDW60191.1 - 0.078 13.0 0.0 0.26 11.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3927) Iso_dh PF00180.20 CDW60192.1 - 5e-118 394.2 0.0 5.7e-118 394.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase tRNA_synt_1c_R1 PF04558.15 CDW60192.1 - 0.12 12.4 0.2 0.62 10.1 0.0 2.0 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 NUDIX PF00293.28 CDW60193.1 - 4.8e-15 55.8 0.1 8.9e-15 54.9 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain PseudoU_synth_2 PF00849.22 CDW60193.1 - 2.5e-09 37.4 0.0 4.6e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 RNA pseudouridylate synthase Cyc-maltodext_C PF10438.9 CDW60193.1 - 0.051 13.7 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 Cyclo-malto-dextrinase C-terminal domain tRNA_Me_trans PF03054.16 CDW60194.1 - 6.3e-145 482.4 0.0 7.1e-145 482.3 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 CDW60194.1 - 1.3e-09 37.5 0.0 1.6e-07 30.7 0.0 2.2 2 0 0 2 2 2 2 NAD synthase ThiI PF02568.14 CDW60194.1 - 1.1e-05 25.1 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 CDW60194.1 - 0.00016 21.2 0.0 0.00058 19.4 0.0 1.9 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 CDW60194.1 - 0.00062 19.5 0.0 0.00082 19.1 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.20 CDW60194.1 - 0.09 12.5 0.2 0.31 10.8 0.1 2.1 2 1 0 2 2 2 0 PP-loop family Lyase_1 PF00206.20 CDW60195.1 - 6.8e-52 176.8 0.0 7.6e-52 176.6 0.0 1.0 1 0 0 1 1 1 1 Lyase MH2 PF03166.14 CDW60196.1 - 2.6e-63 213.6 0.0 3.6e-63 213.2 0.0 1.1 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 CDW60196.1 - 6e-38 129.2 0.1 1.1e-37 128.3 0.1 1.4 1 0 0 1 1 1 1 MH1 domain JAB PF01398.21 CDW60197.1 - 4.9e-28 97.5 0.0 7.8e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 CDW60197.1 - 6.8e-09 35.5 0.0 9.4e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 CDW60197.1 - 0.00081 19.5 0.0 0.001 19.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Zn-ribbon_8 PF09723.10 CDW60198.1 - 0.036 14.2 0.7 14 5.8 0.0 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-TFIIB PF13453.6 CDW60198.1 - 1.2 8.5 10.2 2.2 7.7 0.6 3.4 2 1 1 3 3 3 0 Transcription factor zinc-finger zf-NADH-PPase PF09297.11 CDW60198.1 - 1.3 8.7 9.8 0.087 12.5 4.3 2.0 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain RRM_1 PF00076.22 CDW60199.1 - 4.7e-30 103.2 0.9 1.2e-13 50.6 0.0 4.7 4 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Med31 PF05669.12 CDW60199.1 - 0.071 13.1 0.1 2.5 8.1 0.0 2.7 3 0 0 3 3 3 0 SOH1 Septin PF00735.18 CDW60201.1 - 1.1e-104 349.6 0.1 1.8e-104 348.9 0.1 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CDW60201.1 - 1.7e-07 31.3 0.0 4.8e-07 29.9 0.0 1.8 2 0 0 2 2 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW60201.1 - 1.6e-05 24.9 0.5 0.00013 21.9 0.2 2.4 2 1 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 CDW60201.1 - 3.6e-05 23.2 0.0 7.2e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 CDW60201.1 - 0.0019 18.3 5.6 0.17 11.9 0.1 3.2 2 1 1 3 3 3 2 Dynamin family AAA_22 PF13401.6 CDW60201.1 - 0.0025 18.1 0.0 0.039 14.2 0.0 2.4 1 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CDW60201.1 - 0.0027 18.2 4.1 0.93 10.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 CDW60201.1 - 0.0031 16.7 0.1 0.0052 16.0 0.1 1.7 1 1 0 1 1 1 1 G-protein alpha subunit GTP_EFTU PF00009.27 CDW60201.1 - 0.0043 16.6 2.1 2.3 7.7 0.0 3.2 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain CCDC144C PF14915.6 CDW60201.1 - 0.0075 15.4 5.9 0.012 14.8 5.9 1.2 1 0 0 1 1 1 1 CCDC144C protein coiled-coil region Seryl_tRNA_N PF02403.22 CDW60201.1 - 0.009 16.2 5.4 0.011 16.0 3.9 2.0 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain AAA_16 PF13191.6 CDW60201.1 - 0.019 15.4 0.1 0.077 13.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Ras PF00071.22 CDW60201.1 - 0.023 14.3 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 Ras family Ploopntkinase3 PF18751.1 CDW60201.1 - 0.024 14.6 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_29 PF13555.6 CDW60201.1 - 0.033 13.9 0.2 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain NACHT PF05729.12 CDW60201.1 - 0.041 13.8 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 CDW60201.1 - 0.041 14.4 0.2 0.13 12.8 0.0 1.8 2 0 0 2 2 2 0 ABC transporter Roc PF08477.13 CDW60201.1 - 0.079 13.2 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 CDW60201.1 - 0.082 12.1 0.2 0.21 10.8 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 CDW60201.1 - 0.15 12.5 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF87 PF01935.17 CDW60201.1 - 0.39 10.8 2.8 9 6.3 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain CCDC-167 PF15188.6 CDW60201.1 - 1.1 9.6 6.3 2.9 8.3 6.3 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 RNA_pol_Rpb2_6 PF00562.28 CDW60202.1 - 3.2e-115 385.3 0.0 6.4e-115 384.3 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.16 CDW60202.1 - 5.7e-28 96.9 0.0 1.2e-27 95.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 CDW60202.1 - 2.3e-18 66.4 0.0 6.8e-18 64.9 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 CDW60202.1 - 6.9e-13 48.4 0.0 1.3e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_4 PF04566.13 CDW60202.1 - 1.3e-05 25.3 0.1 3.2e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 Synaptobrevin PF00957.21 CDW60203.1 - 8.9e-23 79.9 0.1 1.7e-22 79.0 0.1 1.5 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CDW60203.1 - 7.9e-19 67.5 0.0 1.2e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Hist_deacetyl PF00850.19 CDW60204.1 - 5.6e-73 246.1 0.0 6.9e-73 245.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain rve PF00665.26 CDW60205.1 - 2.9e-15 56.5 0.1 7.4e-15 55.2 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDW60205.1 - 8.6e-15 54.6 0.3 2.4e-14 53.2 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain SCAI PF12070.8 CDW60205.1 - 6.8e-14 51.6 1.8 1e-13 51.0 1.8 1.2 1 0 0 1 1 1 1 Protein SCAI rve_3 PF13683.6 CDW60205.1 - 4.2e-05 23.2 0.0 0.00016 21.4 0.0 2.0 2 0 0 2 2 2 1 Integrase core domain zf-H2C2 PF09337.10 CDW60205.1 - 5.4e-05 23.3 0.1 0.00014 22.0 0.1 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Trypsin PF00089.26 CDW60206.1 - 5.1e-16 59.2 0.1 3.5e-08 33.5 0.0 2.4 2 0 0 2 2 2 2 Trypsin Retrotrans_gag PF03732.17 CDW60207.1 - 0.022 15.0 0.0 0.051 13.8 0.0 1.6 1 0 0 1 1 1 0 Retrotransposon gag protein zf-CCHC_2 PF13696.6 CDW60207.1 - 0.051 13.4 11.6 1.5 8.7 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 CDW60207.1 - 1.9 8.3 18.3 5.2 6.9 3.4 2.4 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger Trypsin PF00089.26 CDW60208.1 - 3.1e-08 33.7 0.0 8e-08 32.4 0.0 1.6 1 1 0 1 1 1 1 Trypsin Enolase_C PF00113.22 CDW60209.1 - 1.1e-141 471.3 4.0 1.8e-141 470.6 4.0 1.3 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain CTP_synth_N PF06418.14 CDW60209.1 - 4.3e-125 416.4 0.0 1e-124 415.1 0.0 1.6 2 0 0 2 2 2 1 CTP synthase N-terminus GATase PF00117.28 CDW60209.1 - 1.1e-63 214.5 0.0 1.9e-63 213.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Enolase_N PF03952.16 CDW60209.1 - 1.9e-58 196.3 0.3 4.7e-58 195.0 0.3 1.7 1 0 0 1 1 1 1 Enolase, N-terminal domain Peptidase_C26 PF07722.13 CDW60209.1 - 1.5e-08 34.7 1.0 1.1e-07 31.9 0.2 2.5 2 1 0 2 2 2 1 Peptidase C26 MR_MLE_C PF13378.6 CDW60209.1 - 7.5e-07 28.9 0.0 1.3e-05 24.8 0.0 2.5 2 1 0 2 2 2 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CDW60209.1 - 0.0019 17.4 0.3 0.0052 16.0 0.0 1.8 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus CbiA PF01656.23 CDW60209.1 - 0.0049 16.9 0.0 0.071 13.2 0.0 2.4 2 2 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain PemK_toxin PF02452.17 CDW60210.1 - 1.7e-22 79.9 0.0 1.9e-22 79.7 0.0 1.0 1 0 0 1 1 1 1 PemK-like, MazF-like toxin of type II toxin-antitoxin system HD_4 PF13328.6 CDW60211.1 - 4.1e-40 137.1 0.7 8.9e-40 136.0 0.7 1.6 1 0 0 1 1 1 1 HD domain RelA_SpoT PF04607.17 CDW60211.1 - 1.6e-36 125.1 0.2 5.5e-36 123.4 0.0 2.0 2 0 0 2 2 2 1 Region found in RelA / SpoT proteins tRNA_U5-meth_tr PF05958.11 CDW60211.1 - 9e-27 94.0 0.0 1e-25 90.5 0.0 2.5 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase TGS PF02824.21 CDW60211.1 - 2e-21 75.8 0.1 8.9e-21 73.7 0.0 2.2 2 0 0 2 2 2 1 TGS domain ACT_4 PF13291.6 CDW60211.1 - 3.7e-18 65.9 1.4 1e-17 64.5 1.4 1.8 1 0 0 1 1 1 1 ACT domain Methyltransf_31 PF13847.6 CDW60211.1 - 4.3e-13 49.3 0.0 1.1e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TRAM PF01938.20 CDW60211.1 - 1.1e-12 47.7 2.4 1.2e-12 47.6 0.1 2.3 3 0 0 3 3 2 1 TRAM domain ACT PF01842.25 CDW60211.1 - 1.4e-09 37.5 0.3 5.3e-09 35.7 0.3 2.1 1 0 0 1 1 1 1 ACT domain Methyltransf_25 PF13649.6 CDW60211.1 - 2.1e-09 37.9 0.0 5.1e-08 33.5 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CDW60211.1 - 3.4e-07 30.2 0.0 7.4e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RrnaAD PF00398.20 CDW60211.1 - 1.6e-06 27.4 0.0 2.8e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Met_10 PF02475.16 CDW60211.1 - 8.2e-06 25.7 0.0 2.3e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.12 CDW60211.1 - 3.8e-05 24.2 0.0 0.00016 22.3 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CDW60211.1 - 0.00039 20.0 0.0 0.00093 18.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDW60211.1 - 0.0004 20.1 0.0 0.0012 18.5 0.0 1.7 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 CDW60211.1 - 0.0016 18.3 0.0 0.0038 17.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 CDW60211.1 - 0.0036 17.0 0.0 0.016 14.8 0.0 2.1 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltransf_15 PF09445.10 CDW60211.1 - 0.005 16.4 0.0 0.018 14.6 0.0 1.9 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 CDW60211.1 - 0.0062 16.2 0.0 3.6 7.2 0.0 3.0 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.17 CDW60211.1 - 0.007 15.9 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Prok-JAB PF14464.6 CDW60211.1 - 0.028 14.2 0.0 0.094 12.5 0.0 1.9 1 0 0 1 1 1 0 Prokaryotic homologs of the JAB domain Ubie_methyltran PF01209.18 CDW60211.1 - 0.045 13.1 0.0 0.089 12.1 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AAA_26 PF13500.6 CDW60211.1 - 0.16 11.8 0.2 0.7 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF2222 PF09984.9 CDW60212.1 - 1.9e-54 183.6 0.3 4.6e-54 182.3 0.3 1.7 1 0 0 1 1 1 1 Uncharacterised signal transduction histidine kinase domain (DUF2222) HATPase_c PF02518.26 CDW60212.1 - 2e-32 112.0 0.3 3.5e-32 111.2 0.3 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CDW60212.1 - 3.2e-29 101.3 4.2 3.8e-29 101.1 0.5 2.7 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 CDW60212.1 - 5.1e-21 74.5 5.1 2.2e-20 72.4 0.2 3.8 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Hpt PF01627.23 CDW60212.1 - 9.1e-13 48.3 2.5 1.4e-12 47.7 0.1 2.7 2 0 0 2 2 2 1 Hpt domain HAMP PF00672.25 CDW60212.1 - 6.8e-07 29.6 1.0 1.8e-06 28.2 1.0 1.8 1 0 0 1 1 1 1 HAMP domain HATPase_c_3 PF13589.6 CDW60212.1 - 0.032 14.1 0.1 0.073 12.9 0.1 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1640 PF07798.11 CDW60212.1 - 0.37 10.8 4.7 1.1 9.3 4.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) MR_MLE_C PF13378.6 CDW60213.1 - 8.9e-39 133.3 0.1 1.1e-38 133.1 0.1 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like eIF-1a PF01176.19 CDW60214.1 - 2.9e-22 78.3 0.2 4.4e-22 77.7 0.2 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Ribosomal_L2_C PF03947.18 CDW60215.1 - 7.5e-15 55.3 0.0 1.2e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain SRR1 PF07985.12 CDW60215.1 - 9.2e-12 44.8 0.0 1.6e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 SRR1 Ribosomal_L2 PF00181.23 CDW60215.1 - 4.5e-06 26.5 0.1 1.5e-05 24.9 0.1 1.9 1 1 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain WD40 PF00400.32 CDW60216.1 - 6.2e-23 80.6 24.8 1.4e-05 25.7 0.2 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 CDW60216.1 - 6.3e-05 21.8 3.6 0.098 11.3 0.4 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Frtz PF11768.8 CDW60216.1 - 0.022 13.1 0.0 1.9 6.7 0.0 2.1 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz NDUFB10 PF10249.9 CDW60217.1 - 1e-48 165.0 5.2 1.5e-48 164.4 5.2 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 CDP-OH_P_transf PF01066.21 CDW60219.1 - 6.8e-19 68.4 0.3 6.8e-19 68.4 0.3 1.9 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase HTH_6 PF01418.17 CDW60220.1 - 1.7e-33 114.4 0.1 3.1e-33 113.6 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain, rpiR family SIS PF01380.22 CDW60220.1 - 3.2e-13 49.7 0.1 1.1e-12 47.9 0.0 1.8 2 0 0 2 2 2 1 SIS domain SIS_2 PF13580.6 CDW60220.1 - 1.8e-05 24.8 0.6 0.034 14.2 0.1 2.6 1 1 1 2 2 2 2 SIS domain HTH_Tnp_ISL3 PF13542.6 CDW60220.1 - 0.13 11.7 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 G6PD_C PF02781.16 CDW60221.1 - 9e-118 392.7 0.0 1.2e-117 392.3 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CDW60221.1 - 7.8e-58 196.0 0.0 2.2e-57 194.6 0.0 1.7 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 CDW60221.1 - 0.0019 19.0 0.0 0.0037 18.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold ILVD_EDD PF00920.21 CDW60222.1 - 4.3e-159 530.4 0.0 4.9e-159 530.2 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family zf-A20 PF01754.16 CDW60222.1 - 0.39 10.7 1.4 0.76 9.8 1.4 1.4 1 0 0 1 1 1 0 A20-like zinc finger Aldolase PF01081.19 CDW60223.1 - 1.9e-94 314.6 0.7 2.2e-94 314.4 0.7 1.0 1 0 0 1 1 1 1 KDPG and KHG aldolase HMGL-like PF00682.19 CDW60223.1 - 0.01 15.4 0.3 0.016 14.8 0.3 1.2 1 0 0 1 1 1 0 HMGL-like ATP-grasp PF02222.22 CDW60224.1 - 2.8e-57 193.0 0.0 4.3e-57 192.4 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CDW60224.1 - 4.9e-08 32.7 0.0 2e-07 30.7 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 CDW60224.1 - 7e-07 28.9 0.0 1.2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 CDW60224.1 - 1e-06 28.9 0.0 2.7e-06 27.5 0.0 1.7 1 1 0 1 1 1 1 ATP-grasp domain Epimerase PF01370.21 CDW60224.1 - 0.00048 19.7 0.0 0.00088 18.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family LAL_C2 PF18603.1 CDW60224.1 - 0.0031 17.6 0.2 0.01 16.0 0.2 1.8 1 0 0 1 1 1 1 L-amino acid ligase C-terminal domain 2 2-Hacid_dh_C PF02826.19 CDW60224.1 - 0.007 15.7 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ATP-grasp_4 PF13535.6 CDW60224.1 - 0.032 13.8 0.0 0.071 12.7 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Ribosomal_S5 PF00333.20 CDW60224.1 - 0.047 13.7 0.3 0.12 12.4 0.3 1.6 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain YebG PF07130.12 CDW60225.1 - 5.3e-34 115.9 1.6 6.6e-34 115.6 1.6 1.1 1 0 0 1 1 1 1 YebG protein DUF533 PF04391.12 CDW60226.1 - 5.9e-49 166.1 0.4 1e-48 165.3 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF533) YebF PF13995.6 CDW60226.1 - 1.5e-33 114.6 0.2 3.2e-33 113.6 0.2 1.5 1 0 0 1 1 1 1 YebF-like protein TerB PF05099.13 CDW60226.1 - 0.0066 16.4 0.9 0.013 15.4 0.8 1.6 1 1 0 1 1 1 1 Tellurite resistance protein TerB YtxH PF12732.7 CDW60226.1 - 7.1 7.2 6.2 33 5.1 6.2 2.1 1 1 0 1 1 1 0 YtxH-like protein Peptidase_S9_N PF02897.15 CDW60227.1 - 6.1e-119 397.5 3.2 7.4e-119 397.2 3.2 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 CDW60227.1 - 7e-53 179.2 0.1 1.3e-52 178.3 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF4833 PF16117.5 CDW60227.1 - 0.006 16.6 0.1 0.23 11.5 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4833) Tannase PF07519.11 CDW60227.1 - 0.047 12.6 0.0 0.083 11.8 0.0 1.3 1 0 0 1 1 1 0 Tannase and feruloyl esterase RNase_T PF00929.24 CDW60228.1 - 1e-14 55.4 0.0 6.5e-14 52.8 0.0 1.9 1 1 0 1 1 1 1 Exonuclease CN_hydrolase PF00795.22 CDW60228.1 - 1.5e-05 24.4 0.0 0.0047 16.3 0.0 2.2 1 1 1 2 2 2 2 Carbon-nitrogen hydrolase DNA_pol3_theta PF06440.11 CDW60229.1 - 3.1e-37 126.1 0.3 3.4e-37 125.9 0.3 1.0 1 0 0 1 1 1 1 DNA polymerase III, theta subunit MMM1 PF10296.9 CDW60229.1 - 0.09 11.8 0.0 0.092 11.8 0.0 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 zf-CCHC PF00098.23 CDW60231.1 - 0.0045 17.0 2.2 0.0095 16.0 2.2 1.5 1 0 0 1 1 1 1 Zinc knuckle HEXIM PF15313.6 CDW60232.1 - 6.3e-40 136.6 3.4 9.4e-40 136.1 3.4 1.3 1 0 0 1 1 1 1 Hexamethylene bis-acetamide-inducible protein Amnionless PF14828.6 CDW60233.1 - 0.00017 20.6 0.0 0.00017 20.6 0.0 1.0 1 0 0 1 1 1 1 Amnionless CHCH PF06747.13 CDW60234.1 - 0.00012 22.0 6.5 0.00061 19.8 1.0 2.8 2 1 1 3 3 3 1 CHCH domain GCK PF07802.11 CDW60234.1 - 0.0024 18.2 1.7 0.0024 18.2 1.7 2.7 2 1 1 3 3 3 1 GCK domain Cmc1 PF08583.10 CDW60234.1 - 0.0074 16.3 7.0 0.012 15.7 0.9 2.2 1 1 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 CDW60234.1 - 0.054 13.5 6.9 0.58 10.2 1.5 2.8 2 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UPF0203 PF05254.12 CDW60234.1 - 0.52 10.6 7.4 5.9 7.2 2.2 3.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 CDW60234.1 - 1.3 9.3 6.2 1.1 9.6 3.5 2.2 2 1 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein Pet191_N PF10203.9 CDW60234.1 - 3.2 8.1 7.7 6.3 7.2 0.6 2.7 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Med7 PF05983.11 CDW60236.1 - 8.5e-47 159.7 5.0 2.7e-45 154.8 5.0 2.1 1 1 0 1 1 1 1 MED7 protein NOB1_Zn_bind PF08772.11 CDW60237.1 - 2.3e-25 88.6 0.8 4.2e-25 87.7 0.8 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 CDW60237.1 - 2.7e-24 85.5 0.0 5.4e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 PIN domain of ribonuclease DZR PF12773.7 CDW60237.1 - 0.023 14.7 0.5 0.046 13.8 0.5 1.5 1 0 0 1 1 1 0 Double zinc ribbon S_100 PF01023.19 CDW60237.1 - 0.2 11.4 0.1 0.2 11.4 0.1 2.1 3 0 0 3 3 3 0 S-100/ICaBP type calcium binding domain SMC_N PF02463.19 CDW60238.1 - 9.9e-30 103.6 28.6 5.2e-29 101.2 28.6 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDW60238.1 - 2.3e-09 37.4 24.8 2.7e-07 30.7 24.8 2.6 1 1 0 1 1 1 1 AAA ATPase domain CCDC144C PF14915.6 CDW60238.1 - 3.4e-06 26.4 39.9 5.8e-06 25.7 23.1 2.5 1 1 1 2 2 2 2 CCDC144C protein coiled-coil region AAA_23 PF13476.6 CDW60238.1 - 3.9e-06 27.5 49.5 13 6.2 49.3 3.8 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 CDW60238.1 - 2.3e-05 24.4 0.1 2.3e-05 24.4 0.1 3.0 3 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW60238.1 - 0.00045 19.9 0.0 0.00088 19.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Fib_alpha PF08702.10 CDW60238.1 - 0.0041 17.3 13.1 0.0041 17.3 13.1 3.1 3 0 0 3 3 3 2 Fibrinogen alpha/beta chain family Fez1 PF06818.15 CDW60238.1 - 0.0063 17.0 21.8 0.0063 17.0 21.8 2.9 2 1 0 3 3 3 1 Fez1 APG6_N PF17675.1 CDW60238.1 - 0.032 14.7 43.0 0.19 12.2 25.6 3.4 2 1 0 2 2 2 0 Apg6 coiled-coil region FliJ PF02050.16 CDW60238.1 - 0.056 13.7 36.0 0.061 13.5 10.6 3.6 1 1 3 4 4 4 0 Flagellar FliJ protein CENP-F_leu_zip PF10473.9 CDW60238.1 - 0.059 13.4 41.8 0.31 11.1 11.3 3.9 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 CDW60238.1 - 0.11 11.2 38.9 0.046 12.4 16.5 2.4 1 1 1 2 2 2 0 AAA domain Spc7 PF08317.11 CDW60238.1 - 0.14 11.0 50.4 0.04 12.8 14.1 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein MscS_porin PF12795.7 CDW60238.1 - 0.38 10.3 33.8 2 7.9 7.3 3.1 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain ABC_tran PF00005.27 CDW60238.1 - 0.47 11.0 0.0 0.47 11.0 0.0 3.7 3 1 0 3 3 2 0 ABC transporter Sec34 PF04136.15 CDW60238.1 - 1.1 9.1 26.6 0.29 11.0 3.3 3.6 1 1 2 3 3 3 0 Sec34-like family DUF3138 PF11336.8 CDW60238.1 - 1.8 7.1 4.8 0.23 10.0 0.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3138) DUF812 PF05667.11 CDW60238.1 - 2.9 6.7 42.1 4.3 6.1 24.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF812) HIP1_clath_bdg PF16515.5 CDW60238.1 - 4.2 8.0 35.4 3 8.5 4.5 3.7 2 2 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 CDW60238.1 - 5.5 6.3 34.7 0.37 10.1 10.1 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.11 CDW60238.1 - 8.7 6.1 26.0 0.98 9.2 11.1 3.6 1 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Flavodoxin_2 PF02525.17 CDW60239.1 - 9.4e-38 129.9 0.0 1.4e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 CDW60239.1 - 0.13 12.0 0.1 0.55 10.0 0.1 1.8 1 1 0 1 1 1 0 NADPH-dependent FMN reductase ABM PF03992.16 CDW60240.1 - 1.2e-28 99.0 0.1 1.5e-28 98.8 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DNA_gyraseB PF00204.25 CDW60241.1 - 2.1e-39 134.8 0.0 3.9e-39 133.9 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase B DNA_gyraseB_C PF00986.21 CDW60241.1 - 4.5e-25 87.6 1.6 9.6e-25 86.5 1.6 1.6 1 0 0 1 1 1 1 DNA gyrase B subunit, carboxyl terminus HATPase_c PF02518.26 CDW60241.1 - 1.1e-16 61.3 0.1 2.1e-16 60.4 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CDW60241.1 - 2.6e-11 43.7 0.0 4.7e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Toprim domain HATPase_c_3 PF13589.6 CDW60241.1 - 0.0011 18.8 0.1 0.0023 17.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TOPRIM_C PF16898.5 CDW60241.1 - 0.0041 17.4 0.1 0.0081 16.4 0.1 1.4 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM UPF0227 PF05728.12 CDW60242.1 - 8.8e-57 192.1 0.0 9.8e-57 191.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.7 CDW60242.1 - 0.0011 19.6 0.1 0.11 13.0 0.0 2.0 1 1 1 2 2 2 2 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDW60242.1 - 0.027 13.7 0.0 0.15 11.3 0.0 1.9 1 1 0 2 2 2 0 Serine aminopeptidase, S33 DUF1249 PF06853.12 CDW60243.1 - 3e-20 72.4 0.1 5.6e-20 71.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1249) Metallophos PF00149.28 CDW60243.1 - 8.5e-20 72.1 0.7 1.2e-19 71.6 0.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NUDIX PF00293.28 CDW60243.1 - 4.2e-10 39.8 0.1 1.1e-09 38.4 0.1 1.8 1 0 0 1 1 1 1 NUDIX domain Metallophos_2 PF12850.7 CDW60243.1 - 1.7e-08 34.8 0.1 3.6e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain FAM35_C PF15793.5 CDW60243.1 - 0.052 13.0 0.0 0.7 9.3 0.0 2.4 2 1 0 2 2 2 0 Protein family FAM35, C-terminal OEP PF02321.18 CDW60244.1 - 2.5e-59 200.3 39.3 5e-33 114.5 11.9 2.1 2 0 0 2 2 2 2 Outer membrane efflux protein DUF5618 PF18498.1 CDW60244.1 - 0.1 12.8 5.3 3 8.1 0.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF5618) DUF1190 PF06693.11 CDW60245.1 - 1.2e-57 194.8 13.4 1.4e-57 194.6 13.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1190) SARAF PF06682.12 CDW60245.1 - 0.015 15.0 6.5 0.018 14.7 6.5 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis GSP_synth PF03738.14 CDW60246.1 - 3.5e-156 520.1 0.1 4e-156 520.0 0.1 1.0 1 0 0 1 1 1 1 Glutathionylspermidine synthase preATP-grasp LigB PF02900.18 CDW60247.1 - 2.6e-25 89.0 0.0 3.2e-25 88.7 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Zip PF02535.22 CDW60248.1 - 1.3e-26 93.6 16.5 2.7e-25 89.3 11.0 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter E1-E2_ATPase PF00122.20 CDW60248.1 - 0.16 11.5 0.1 0.16 11.5 0.1 2.0 2 0 0 2 2 2 0 E1-E2 ATPase DHBP_synthase PF00926.19 CDW60249.1 - 3.2e-78 261.7 0.9 3.6e-78 261.5 0.9 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase Tweety PF04906.13 CDW60250.1 - 1.5e-09 37.0 1.1 1.7e-09 36.9 1.1 1.0 1 0 0 1 1 1 1 Tweety ETRAMP PF09716.10 CDW60250.1 - 0.0004 20.4 0.6 0.007 16.4 0.6 2.1 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) PMP22_Claudin PF00822.20 CDW60250.1 - 0.0022 17.9 1.5 0.0027 17.6 1.5 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family 7tm_3 PF00003.22 CDW60250.1 - 0.0082 15.9 2.5 0.0089 15.8 2.5 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 12TM_1 PF09847.9 CDW60250.1 - 0.019 14.1 0.2 0.019 14.1 0.2 1.0 1 0 0 1 1 1 0 Membrane protein of 12 TMs TMEM154 PF15102.6 CDW60250.1 - 0.036 14.0 0.3 0.23 11.4 0.0 1.9 1 1 1 2 2 2 0 TMEM154 protein family DUF2207 PF09972.9 CDW60250.1 - 0.045 12.5 0.2 0.053 12.3 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HupE_UreJ PF04955.12 CDW60250.1 - 0.071 12.6 0.1 1.8 8.0 0.1 2.1 1 1 0 1 1 1 0 HupE / UreJ protein Prominin PF05478.11 CDW60250.1 - 0.11 10.4 1.0 0.13 10.2 1.0 1.1 1 0 0 1 1 1 0 Prominin Insulin_TMD PF17870.1 CDW60250.1 - 0.19 11.8 5.3 2.2 8.4 1.1 2.2 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment EphA2_TM PF14575.6 CDW60250.1 - 2 9.4 3.6 45 5.0 3.6 2.1 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5056 PF16479.5 CDW60250.1 - 5.6 7.3 6.9 4.8 7.5 4.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5056) IF3_N PF05198.16 CDW60251.1 - 4.1e-06 27.0 0.1 7.1e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 CDW60251.1 - 8.3e-05 22.5 0.3 0.00014 21.8 0.3 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 CDW60251.1 - 0.014 15.1 1.9 0.23 11.1 0.7 2.1 1 1 1 2 2 2 0 Mitochondrial translation initiation factor HV_small_capsid PF17086.5 CDW60251.1 - 0.32 11.3 2.1 0.91 9.9 0.9 2.1 1 1 1 2 2 2 0 Small capsid protein of Herpesviridae Isy1 PF06246.12 CDW60252.1 - 4.2e-90 301.8 4.7 5.7e-90 301.3 4.7 1.2 1 0 0 1 1 1 1 Isy1-like splicing family Fringe PF02434.16 CDW60252.1 - 1.7e-44 152.2 0.5 2.4e-41 141.9 0.3 2.2 2 0 0 2 2 2 2 Fringe-like Rab5ip PF07019.12 CDW60252.1 - 1.3e-12 48.1 6.0 1.3e-12 48.1 6.0 1.9 2 0 0 2 2 2 1 Rab5-interacting protein (Rab5ip) Mannosidase_ig PF17786.1 CDW60253.1 - 0.018 15.6 0.0 0.063 13.9 0.0 1.8 2 0 0 2 2 2 0 Mannosidase Ig/CBM-like domain Glyco_transf_8 PF01501.20 CDW60254.1 - 6e-13 48.9 0.5 1.1e-12 48.1 0.5 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 tRNA-synt_1c PF00749.21 CDW60255.1 - 7.8e-44 149.8 0.1 1.4e-43 149.0 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CDW60255.1 - 6.4e-32 110.8 0.1 1e-31 110.2 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain WD40 PF00400.32 CDW60256.1 - 1.8e-09 38.0 7.3 4.5e-09 36.8 2.4 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW60256.1 - 0.00011 22.5 0.0 0.00022 21.4 0.0 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 CDW60256.1 - 0.0023 17.3 0.0 0.0027 17.1 0.0 1.1 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Nbas_N PF15492.6 CDW60256.1 - 0.0033 16.8 0.0 0.0038 16.6 0.0 1.1 1 0 0 1 1 1 1 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 CDW60256.1 - 0.02 13.9 0.0 0.023 13.7 0.0 1.1 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Phage_tail_NK PF16532.5 CDW60256.1 - 0.12 11.9 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales PI3_PI4_kinase PF00454.27 CDW60257.1 - 4.1e-53 180.7 0.0 4.9e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Toxin_16 PF07945.11 CDW60257.1 - 5.9 6.9 10.9 1.1 9.2 6.9 1.8 2 0 0 2 2 2 0 Janus-atracotoxin Histone PF00125.24 CDW60258.1 - 6.2e-50 168.9 4.5 6.9e-50 168.8 4.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW60258.1 - 3.4e-05 24.5 0.8 3.9e-05 24.2 0.8 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW60258.1 - 0.00011 22.3 0.2 0.00011 22.3 0.2 1.8 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW60258.1 - 0.0023 18.2 0.1 0.0038 17.6 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW60258.1 - 0.012 15.6 0.2 0.03 14.4 0.1 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW60258.1 - 0.048 13.9 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone WAP PF00095.21 CDW60259.1 - 3.1e-15 56.3 30.0 9.1e-10 38.8 11.6 2.1 2 0 0 2 2 2 2 WAP-type (Whey Acidic Protein) 'four-disulfide core' HigB_toxin PF09907.9 CDW60260.1 - 0.02 15.1 0.1 0.039 14.2 0.1 1.5 1 0 0 1 1 1 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system TBD PF12845.7 CDW60260.1 - 0.035 14.0 0.2 0.082 12.8 0.2 1.7 1 0 0 1 1 1 0 TBD domain Cation_efflux PF01545.21 CDW60261.1 - 1.4e-25 90.2 6.8 1.9e-25 89.8 6.8 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CDW60261.1 - 1.4e-12 47.5 1.1 5.2e-12 45.7 0.8 1.9 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter TPR_14 PF13428.6 CDW60262.1 - 4.5e-11 42.6 0.0 0.0051 17.5 0.0 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 CDW60262.1 - 1.4e-09 37.4 0.0 0.058 13.2 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW60262.1 - 1.6e-09 37.1 0.0 1.3 9.4 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 CDW60262.1 - 3.5e-09 37.0 1.1 0.00086 19.8 0.1 4.2 4 2 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 CDW60262.1 - 4.6e-08 32.5 0.0 0.44 10.7 0.0 5.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CDW60262.1 - 2e-07 31.2 0.2 0.25 11.7 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW60262.1 - 4.8e-07 29.5 0.1 0.49 10.7 0.0 6.0 5 1 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 CDW60262.1 - 2.4e-05 24.7 2.2 13 6.7 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CDW60262.1 - 0.00012 21.6 0.6 0.03 13.7 0.0 3.2 3 1 1 4 4 4 1 MalT-like TPR region TPR_10 PF13374.6 CDW60262.1 - 0.00018 21.3 0.6 16 5.5 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 CDW60262.1 - 0.00019 21.5 0.1 0.79 9.9 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW60262.1 - 0.0015 18.7 0.0 17 6.1 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDW60262.1 - 0.0053 17.4 0.1 2.9 8.6 0.0 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 CDW60262.1 - 0.19 12.2 0.1 19 5.7 0.0 2.7 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Cyt-b5 PF00173.28 CDW60263.1 - 4.7e-12 45.9 0.0 6.2e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Orai-1 PF07856.12 CDW60264.1 - 7.2e-48 162.5 16.4 2.4e-45 154.3 16.4 2.0 1 1 0 1 1 1 1 Mediator of CRAC channel activity KASH PF10541.9 CDW60264.1 - 0.093 13.0 0.6 0.093 13.0 0.6 3.3 2 1 1 3 3 3 0 Nuclear envelope localisation domain MpPF26 PF07666.11 CDW60264.1 - 0.7 10.0 14.5 1.1 9.4 12.9 1.9 1 1 1 2 2 2 0 M penetrans paralogue family 26 Cyt_c_ox_IV PF12270.8 CDW60264.1 - 0.7 10.0 6.1 0.49 10.5 1.7 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV DUF4131 PF13567.6 CDW60264.1 - 1.5 8.5 5.5 0.25 11.0 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4191 PF13829.6 CDW60264.1 - 5.3 6.3 4.8 1 8.6 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) DUF2207 PF09972.9 CDW60264.1 - 8.4 5.0 14.0 79 1.8 14.0 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) AhpC-TSA PF00578.21 CDW60265.1 - 1.7e-38 131.4 0.0 2.2e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CDW60265.1 - 1.7e-18 66.8 0.0 2e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CDW60265.1 - 5.2e-12 45.4 0.0 1e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Neur_chan_memb PF02932.16 CDW60266.1 - 1.5e-73 247.8 8.9 1.4e-40 139.9 1.8 2.8 2 1 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF1634 PF07843.11 CDW60266.1 - 0.32 11.1 6.4 3.4 7.8 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1634) O-ag_pol_Wzy PF14296.6 CDW60266.1 - 0.48 9.0 12.9 0.63 8.6 2.6 2.5 3 0 0 3 3 3 0 O-antigen polysaccharide polymerase Wzy SCAI PF12070.8 CDW60267.1 - 6.4e-129 431.2 5.7 1.1e-128 430.4 5.7 1.4 1 1 0 1 1 1 1 Protein SCAI REV1_C PF16727.5 CDW60267.1 - 0.028 14.8 0.4 0.065 13.6 0.4 1.5 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain Tex_N PF09371.10 CDW60268.1 - 4.7e-21 75.3 0.2 8.5e-21 74.4 0.2 1.3 1 0 0 1 1 1 1 Tex-like protein N-terminal domain Tex_YqgF PF16921.5 CDW60268.1 - 0.00016 22.1 0.0 0.00087 19.8 0.0 2.3 2 0 0 2 2 2 1 Tex protein YqgF-like domain OLF PF02191.16 CDW60269.1 - 1.5e-62 211.4 11.6 1.8e-62 211.2 11.6 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Collagen PF01391.18 CDW60269.1 - 7.2e-09 35.3 20.6 1.1e-08 34.7 20.6 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Amelotin PF15757.5 CDW60270.1 - 0.91 9.1 5.0 3.1 7.3 0.3 2.4 2 1 0 2 2 2 0 Amelotin Misat_Tub_SegII PF10644.9 CDW60273.1 - 0.16 12.3 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain RhoGAP PF00620.27 CDW60275.1 - 6.8e-32 110.4 0.3 1.4e-31 109.4 0.3 1.5 1 0 0 1 1 1 1 RhoGAP domain RVT_1 PF00078.27 CDW60275.1 - 4.2e-06 26.4 0.0 8.4e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Calponin PF00402.18 CDW60276.1 - 3.1e-11 42.7 1.3 4.3e-11 42.3 1.3 1.2 1 0 0 1 1 1 1 Calponin family repeat CH PF00307.31 CDW60276.1 - 5.7e-05 23.2 0.0 0.00011 22.4 0.0 1.5 1 1 0 1 1 1 1 Calponin homology (CH) domain DALR_1 PF05746.15 CDW60277.1 - 2 8.6 3.9 4.2 7.6 2.7 2.2 2 0 0 2 2 2 0 DALR anticodon binding domain LisH PF08513.11 CDW60278.1 - 0.0066 16.4 0.1 0.015 15.3 0.1 1.6 1 0 0 1 1 1 1 LisH TILa PF12714.7 CDW60279.1 - 0.041 13.9 1.4 12 5.9 0.0 3.7 3 1 0 3 3 3 0 TILa domain MIG-14_Wnt-bd PF06664.12 CDW60280.1 - 6.8e-84 281.5 19.8 6.8e-84 281.5 19.8 1.6 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion OTCace PF00185.24 CDW60281.1 - 4.5e-55 186.0 0.1 1e-54 184.9 0.1 1.6 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 CDW60281.1 - 7.3e-49 165.6 0.0 1.1e-48 165.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RraB PF06877.11 CDW60282.1 - 1.5e-34 118.7 0.7 2e-34 118.4 0.7 1.2 1 0 0 1 1 1 1 Regulator of ribonuclease activity B Ag332 PF04671.12 CDW60282.1 - 2.5 8.1 8.0 1.7 8.7 0.2 3.4 3 0 0 3 3 3 0 Erythrocyte membrane-associated giant protein antigen 332 Acetyltransf_1 PF00583.25 CDW60283.1 - 9.9e-16 58.0 0.1 1.1e-15 57.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CDW60283.1 - 7.9e-12 45.4 0.1 1.2e-11 44.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDW60283.1 - 9.6e-10 38.5 0.0 1.2e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CDW60283.1 - 1e-05 26.2 0.0 1.2e-05 25.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CDW60283.1 - 1.8e-05 25.0 0.0 2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW60283.1 - 3.5e-05 23.7 0.0 6.4e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CDW60283.1 - 5.2e-05 23.3 0.0 8.7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CDW60283.1 - 0.013 15.6 0.1 0.029 14.4 0.1 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CDW60283.1 - 0.053 13.0 0.0 0.52 9.7 0.0 2.1 1 1 0 1 1 1 0 Putative acetyl-transferase tRNA-synt_1 PF00133.22 CDW60284.1 - 1e-233 777.0 0.8 1.3e-232 773.4 0.8 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CDW60284.1 - 1.6e-42 145.0 0.0 4e-42 143.7 0.0 1.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CDW60284.1 - 1.1e-17 63.9 1.3 1.8e-07 30.3 0.1 4.9 4 2 0 4 4 4 3 tRNA synthetases class I (M) Val_tRNA-synt_C PF10458.9 CDW60284.1 - 2.1e-16 59.9 6.8 5.4e-16 58.6 6.8 1.7 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1_2 PF13603.6 CDW60284.1 - 6.7e-09 35.5 0.0 1.7e-06 27.7 0.0 2.4 1 1 1 2 2 2 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1f PF01921.18 CDW60284.1 - 0.038 12.9 0.0 0.07 12.0 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) ABC_tran_CTD PF16326.5 CDW60284.1 - 0.098 12.9 4.4 0.28 11.5 4.4 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain tRNA-synt_1b PF00579.25 CDW60284.1 - 0.26 10.6 0.0 0.26 10.6 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) Peptidase_M17 PF00883.21 CDW60285.1 - 9.6e-125 416.0 0.2 1.5e-124 415.3 0.1 1.3 2 0 0 2 2 2 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 CDW60285.1 - 3.4e-34 117.4 0.0 1.1e-33 115.8 0.0 1.9 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain LptF_LptG PF03739.14 CDW60286.1 - 2.5e-57 194.3 3.2 3e-57 194.1 3.2 1.0 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG HemY_N PF07219.13 CDW60286.1 - 0.13 12.5 0.2 0.13 12.5 0.2 3.1 4 0 0 4 4 4 0 HemY protein N-terminus DUF4870 PF09685.10 CDW60286.1 - 3.3 7.9 10.5 1.3 9.2 2.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4870) LptF_LptG PF03739.14 CDW60287.1 - 8.7e-31 107.0 3.0 9.5e-31 106.9 3.0 1.0 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG FtsX PF02687.21 CDW60287.1 - 0.23 12.0 0.2 0.23 12.0 0.2 2.2 2 1 0 2 2 2 0 FtsX-like permease family Serpin PF00079.20 CDW60288.1 - 1.7e-128 429.1 11.5 2.4e-111 372.7 5.2 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) Translat_reg PF01818.17 CDW60288.1 - 0.03 14.3 0.2 4 7.4 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage translational regulator OST3_OST6 PF04756.13 CDW60288.1 - 0.042 13.2 0.1 0.08 12.3 0.1 1.4 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family RdRP PF05183.12 CDW60289.1 - 4.6e-141 471.4 0.0 7.1e-141 470.7 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase zf-C3HC4_3 PF13920.6 CDW60293.1 - 2.1e-09 37.1 8.2 3e-09 36.6 8.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW60293.1 - 7.6e-09 35.3 10.0 1.1e-08 34.8 10.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW60293.1 - 2.8e-08 33.9 12.4 4e-08 33.5 12.4 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CDW60293.1 - 5.4e-08 32.6 11.2 8.3e-08 32.0 11.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CDW60293.1 - 2.4e-07 30.7 5.9 2.4e-07 30.7 5.9 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDW60293.1 - 3.7e-07 30.0 8.2 5.5e-07 29.4 8.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CDW60293.1 - 6.5e-06 25.9 8.4 1e-05 25.3 8.4 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CDW60293.1 - 5.1e-05 23.3 12.2 8.3e-05 22.7 12.2 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 CDW60293.1 - 0.0002 21.6 8.0 0.00038 20.7 8.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CDW60293.1 - 0.00055 19.9 2.4 0.00086 19.3 2.4 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 CDW60293.1 - 0.0047 16.9 5.1 0.0067 16.4 5.1 1.1 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_6 PF14835.6 CDW60293.1 - 0.061 13.2 3.4 0.11 12.4 3.4 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein U-box PF04564.15 CDW60293.1 - 0.15 12.3 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 U-box domain zf-RING_4 PF14570.6 CDW60293.1 - 3.8 7.4 12.2 20 5.1 12.2 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3024 PF11225.8 CDW60294.1 - 0.065 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) SPRY PF00622.28 CDW60295.1 - 7.8e-18 64.7 0.3 2.1e-17 63.3 0.3 1.7 1 1 0 1 1 1 1 SPRY domain CLTH PF10607.9 CDW60295.1 - 0.0076 16.2 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LIM PF00412.22 CDW60296.1 - 2.4e-15 56.5 24.5 7.6e-10 38.9 4.3 3.4 2 2 1 3 3 3 3 LIM domain T2SSE PF00437.20 CDW60297.1 - 6.3e-88 294.4 0.9 8.4e-88 294.0 0.9 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein T2SSE_N PF05157.15 CDW60297.1 - 0.00023 21.4 0.0 0.00065 19.9 0.0 1.9 1 0 0 1 1 1 1 Type II secretion system (T2SS), protein E, N-terminal domain AAA_16 PF13191.6 CDW60297.1 - 0.00025 21.5 0.3 0.0011 19.4 0.0 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 CDW60297.1 - 0.00051 19.6 0.0 0.0063 16.0 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_30 PF13604.6 CDW60297.1 - 0.00071 19.3 0.0 0.0024 17.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CDW60297.1 - 0.0033 17.7 0.9 0.012 15.8 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CDW60297.1 - 0.0077 15.9 0.1 0.019 14.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_11 PF13086.6 CDW60297.1 - 0.013 15.4 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CDW60297.1 - 0.024 15.0 0.2 0.079 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CDW60297.1 - 0.035 14.2 0.0 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 CDW60297.1 - 0.04 13.4 0.1 0.36 10.2 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein ResIII PF04851.15 CDW60297.1 - 0.05 13.6 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 CDW60297.1 - 0.06 13.8 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CDW60297.1 - 0.14 12.6 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 CDW60297.1 - 0.16 11.2 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NTPase_1 PF03266.15 CDW60297.1 - 0.16 11.9 0.3 1 9.2 0.1 2.3 2 0 0 2 2 2 0 NTPase T2SSF PF00482.23 CDW60298.1 - 1e-55 187.0 1.2 5.9e-29 100.6 0.2 2.2 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein F IMPDH PF00478.25 CDW60299.1 - 3.8e-78 262.9 0.5 4.7e-78 262.6 0.5 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CDW60299.1 - 0.0064 15.6 6.0 0.0098 15.0 5.5 1.4 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NBD_C PF17042.5 CDW60299.1 - 0.057 13.9 0.1 0.37 11.3 0.0 2.1 1 1 1 2 2 2 0 Nucleotide-binding C-terminal domain CoaE PF01121.20 CDW60300.1 - 1.2e-77 259.6 0.3 1.6e-77 259.2 0.3 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_33 PF13671.6 CDW60300.1 - 9.1e-06 25.9 0.4 0.00014 22.1 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 CDW60300.1 - 3e-05 24.3 0.7 0.00031 21.0 0.7 2.3 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CDW60300.1 - 5.6e-05 23.6 0.0 0.00025 21.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDW60300.1 - 6.1e-05 23.6 0.1 0.0003 21.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 CDW60300.1 - 6.2e-05 23.2 1.4 0.32 11.1 0.4 2.5 1 1 1 2 2 2 2 Shikimate kinase Cytidylate_kin2 PF13189.6 CDW60300.1 - 0.0038 17.4 1.0 0.018 15.2 1.0 2.1 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_22 PF13401.6 CDW60300.1 - 0.0084 16.4 0.3 0.07 13.4 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW60300.1 - 0.014 15.1 0.2 0.025 14.3 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ACT PF01842.25 CDW60300.1 - 0.032 14.0 1.6 0.11 12.3 0.4 2.4 2 1 1 3 3 3 0 ACT domain Thymidylate_kin PF02223.17 CDW60300.1 - 0.032 13.9 0.1 0.72 9.5 0.0 2.3 2 0 0 2 2 2 0 Thymidylate kinase Dynamin_N PF00350.23 CDW60300.1 - 0.035 14.2 0.1 0.044 13.9 0.1 1.6 1 1 0 1 1 1 0 Dynamin family PRK PF00485.18 CDW60300.1 - 0.037 13.8 1.0 0.99 9.1 0.1 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ATPase PF06745.13 CDW60300.1 - 0.061 12.7 0.3 0.62 9.4 0.0 2.0 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 CDW60300.1 - 0.061 13.8 1.2 0.11 13.0 1.2 1.8 1 1 0 1 1 1 0 ABC transporter CobU PF02283.16 CDW60300.1 - 0.099 12.2 0.7 2.2 7.8 0.1 2.2 2 0 0 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase APS_kinase PF01583.20 CDW60300.1 - 0.11 12.4 0.1 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_5 PF07728.14 CDW60300.1 - 0.14 12.2 1.5 6.5 6.7 0.1 2.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW60300.1 - 0.14 12.5 3.1 0.87 9.9 3.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain dNK PF01712.19 CDW60300.1 - 0.15 11.9 0.4 0.73 9.7 0.0 2.0 2 1 0 2 2 2 0 Deoxynucleoside kinase ZapD PF07072.11 CDW60301.1 - 1.4e-77 260.2 0.4 1.6e-77 260.0 0.4 1.0 1 0 0 1 1 1 1 Cell division protein SecA_DEAD PF07517.14 CDW60302.1 - 5.5e-132 439.4 0.3 1e-131 438.6 0.3 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain SecA_SW PF07516.13 CDW60302.1 - 1.1e-68 231.2 5.3 1.1e-68 231.2 5.3 2.1 3 0 0 3 3 3 1 SecA Wing and Scaffold domain SecA_PP_bind PF01043.20 CDW60302.1 - 6e-40 136.4 0.2 1.5e-39 135.0 0.2 1.8 1 0 0 1 1 1 1 SecA preprotein cross-linking domain SEC-C PF02810.15 CDW60302.1 - 7.2e-11 41.8 9.7 1.2e-10 41.1 9.7 1.4 1 0 0 1 1 1 1 SEC-C motif DEAD PF00270.29 CDW60302.1 - 0.00018 21.3 0.1 0.0012 18.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF2175 PF09943.9 CDW60302.1 - 0.065 13.5 2.5 0.24 11.7 0.2 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) SecM PF06558.12 CDW60303.1 - 2.3e-55 186.7 1.3 2.6e-55 186.5 1.3 1.0 1 0 0 1 1 1 1 Secretion monitor precursor protein (SecM) Omp28 PF11551.8 CDW60303.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Outer membrane protein Omp28 LpxC PF03331.13 CDW60304.1 - 1.3e-108 362.6 0.0 1.5e-108 362.4 0.0 1.0 1 0 0 1 1 1 1 UDP-3-O-acyl N-acetylglycosamine deacetylase FtsZ_C PF12327.8 CDW60305.1 - 7.6e-38 128.7 1.2 2.2e-37 127.2 1.2 1.8 1 0 0 1 1 1 1 FtsZ family, C-terminal domain Tubulin PF00091.25 CDW60305.1 - 1.1e-37 130.1 0.0 1.7e-37 129.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain NAD_binding_10 PF13460.6 CDW60305.1 - 0.0028 17.6 0.2 0.0074 16.2 0.2 1.7 1 0 0 1 1 1 1 NAD(P)H-binding HATPase_c PF02518.26 CDW60305.1 - 0.086 13.4 0.2 0.23 12.0 0.0 1.7 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Tubulin_2 PF13809.6 CDW60305.1 - 1.8 7.7 3.8 4.7 6.3 3.4 1.9 1 1 0 1 1 1 0 Tubulin like Dimer_Tnp_hAT PF05699.14 CDW60306.1 - 0.00094 18.9 0.0 0.0022 17.7 0.0 1.6 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region FAD_binding_2 PF00890.24 CDW60307.1 - 1.8e-91 307.3 1.3 2.1e-91 307.1 1.3 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CDW60307.1 - 4.7e-12 46.2 2.0 3e-07 30.4 0.9 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CDW60307.1 - 3.4e-10 39.6 1.7 3.4e-10 39.6 1.7 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CDW60307.1 - 1.9e-07 31.2 0.9 4.6e-06 26.8 0.8 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CDW60307.1 - 6.5e-07 29.0 6.6 2.1e-06 27.3 6.6 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CDW60307.1 - 8.3e-06 24.7 6.0 0.0011 17.8 1.3 3.1 3 0 0 3 3 3 2 HI0933-like protein GIDA PF01134.22 CDW60307.1 - 1.6e-05 24.2 9.2 0.00042 19.5 3.1 2.8 3 0 0 3 3 3 2 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CDW60307.1 - 0.00049 19.5 0.8 0.0011 18.3 0.8 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CDW60307.1 - 0.00051 19.4 6.7 0.0099 15.1 1.0 2.7 3 0 0 3 3 3 2 Thi4 family Pyr_redox PF00070.27 CDW60307.1 - 0.0033 17.9 2.1 0.019 15.5 1.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW60307.1 - 0.0058 15.9 0.2 0.71 9.1 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CDW60307.1 - 0.016 14.3 0.0 1.9 7.5 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 CDW60307.1 - 0.019 15.4 0.1 0.042 14.3 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_9 PF13454.6 CDW60307.1 - 0.12 12.3 0.5 18 5.3 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CDW60307.1 - 0.51 9.6 2.4 2.4 7.3 0.6 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 CDW60307.1 - 0.57 9.2 2.1 1.7 7.6 0.9 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Ank_2 PF12796.7 CDW60308.1 - 7.7e-17 61.7 0.9 3.2e-08 34.1 0.0 3.2 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CDW60308.1 - 1.3e-13 49.7 2.9 1.8e-05 24.8 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 CDW60308.1 - 2.1e-12 47.0 0.4 5.8e-06 26.5 0.2 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW60308.1 - 3.6e-12 46.5 1.1 0.0031 18.1 0.0 4.8 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 CDW60308.1 - 1.6e-10 41.0 4.1 0.0051 17.2 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat USP7_C2 PF14533.6 CDW60309.1 - 2.8e-53 180.7 1.4 3.5e-53 180.4 1.4 1.1 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal USP7_ICP0_bdg PF12436.8 CDW60309.1 - 3e-08 33.3 0.0 6e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 Med24_N PF11277.8 CDW60309.1 - 0.05 11.7 0.1 0.066 11.3 0.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Tim29 PF10171.9 CDW60310.1 - 9.9e-30 103.2 0.1 1.2e-29 102.9 0.1 1.0 1 0 0 1 1 1 1 Translocase of the Inner Mitochondrial membrane 29 Beta-Casp PF10996.8 CDW60311.1 - 5.6e-08 33.1 0.0 1.2e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 CDW60311.1 - 0.0002 20.9 0.0 0.00087 18.8 0.0 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Mx_ML PF17536.2 CDW60311.1 - 0.045 13.5 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 Matrix and Matrix long proteins N-terminal Acyl-CoA_dh_1 PF00441.24 CDW60312.1 - 6.4e-43 146.5 1.5 4.3e-40 137.4 1.5 2.4 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CDW60312.1 - 4.3e-22 78.9 0.0 1.4e-21 77.2 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CDW60312.1 - 6.6e-11 42.6 0.0 3.7e-10 40.2 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CDW60312.1 - 7.9e-09 35.6 0.2 6.5e-08 32.7 0.2 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Suv3_N PF18114.1 CDW60315.1 - 9.6e-41 138.6 0.0 2.1e-40 137.5 0.0 1.6 1 0 0 1 1 1 1 Suv3 helical N-terminal domain Suv3_C_1 PF18147.1 CDW60315.1 - 2.8e-14 52.7 0.1 1.4e-13 50.4 0.5 2.1 2 0 0 2 2 2 1 Suv3 C-terminal domain 1 SUV3_C PF12513.8 CDW60315.1 - 3.2e-14 52.6 0.4 1.1e-13 50.9 0.4 2.0 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 CDW60315.1 - 3.9e-11 43.3 0.0 7.5e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3110 PF11360.8 CDW60315.1 - 0.057 13.6 0.0 0.9 9.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3110) Ribosomal_L37e PF01907.19 CDW60316.1 - 1.7e-29 101.7 13.2 2.3e-29 101.3 13.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 CDW60316.1 - 0.0044 17.0 1.6 0.0061 16.6 1.6 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF2688 PF10892.8 CDW60316.1 - 0.018 14.5 5.5 0.12 11.9 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) DUF1258 PF06869.12 CDW60316.1 - 0.043 13.3 1.6 0.05 13.1 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) HypA PF01155.19 CDW60316.1 - 0.076 13.0 0.9 0.093 12.8 0.9 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Tnp_zf-ribbon_2 PF13842.6 CDW60316.1 - 0.25 12.2 7.2 6.1 7.7 1.6 2.4 2 1 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zinc_ribbon_2 PF13240.6 CDW60316.1 - 0.31 10.8 3.0 6.2 6.7 0.2 2.1 2 0 0 2 2 2 0 zinc-ribbon domain LysR_substrate PF03466.20 CDW60318.1 - 4.8e-35 120.8 0.0 5.6e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 LysR substrate binding domain G3P_acyltransf PF02660.15 CDW60319.1 - 6.2e-50 169.4 9.4 7.2e-50 169.2 9.4 1.0 1 0 0 1 1 1 1 Glycerol-3-phosphate acyltransferase FolB PF02152.18 CDW60320.1 - 6.6e-32 110.4 0.4 7.3e-32 110.2 0.4 1.0 1 0 0 1 1 1 1 Dihydroneopterin aldolase DUF2866 PF11065.8 CDW60320.1 - 0.038 14.0 0.0 0.065 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2866) BacA PF02673.18 CDW60321.1 - 1.3e-59 202.0 0.9 1.6e-59 201.7 0.9 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA PolyA_pol PF01743.20 CDW60322.1 - 5.4e-19 68.9 0.4 2.2e-18 66.9 0.0 2.1 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CDW60322.1 - 3.5e-16 58.7 0.1 8.6e-16 57.5 0.1 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A HD PF01966.22 CDW60322.1 - 1.7e-12 47.6 0.1 1.1e-11 45.0 0.0 2.2 2 0 0 2 2 2 1 HD domain SH3_3 PF08239.11 CDW60322.1 - 1.4e-08 34.9 0.2 3.3e-08 33.7 0.2 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Seryl_tRNA_N PF02403.22 CDW60322.1 - 0.005 17.0 6.0 0.011 15.9 6.0 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF2408 PF10303.9 CDW60322.1 - 0.0057 17.2 0.3 0.01 16.4 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) CortBP2 PF09727.9 CDW60322.1 - 0.0067 16.4 1.8 0.0067 16.4 1.8 1.6 2 0 0 2 2 2 1 Cortactin-binding protein-2 DUF948 PF06103.11 CDW60322.1 - 0.013 15.8 0.5 0.039 14.2 0.5 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 CDW60322.1 - 0.018 14.4 2.0 0.031 13.7 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 CDW60322.1 - 0.037 14.1 6.6 0.038 14.1 4.3 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ZapB PF06005.12 CDW60322.1 - 0.048 14.1 4.0 0.11 12.9 4.0 1.6 1 0 0 1 1 1 0 Cell division protein ZapB Ax_dynein_light PF10211.9 CDW60322.1 - 0.067 13.1 2.5 0.14 12.0 2.5 1.5 1 0 0 1 1 1 0 Axonemal dynein light chain UPF0242 PF06785.11 CDW60322.1 - 0.072 13.2 2.1 0.13 12.4 2.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3584 PF12128.8 CDW60322.1 - 0.073 10.6 2.3 0.1 10.1 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TolA_bind_tri PF16331.5 CDW60322.1 - 0.14 12.2 3.2 0.33 11.1 3.2 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation GAS PF13851.6 CDW60322.1 - 0.16 11.3 4.8 0.3 10.4 4.8 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 CDW60322.1 - 0.17 12.3 3.2 0.77 10.2 0.9 2.6 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) Prominin PF05478.11 CDW60322.1 - 0.21 9.5 2.8 0.29 9.1 2.8 1.1 1 0 0 1 1 1 0 Prominin ADIP PF11559.8 CDW60322.1 - 0.26 11.3 6.3 0.24 11.5 4.7 1.7 2 0 0 2 2 1 0 Afadin- and alpha -actinin-Binding TnpV PF14198.6 CDW60322.1 - 0.31 11.0 2.2 0.66 10.0 2.2 1.5 1 0 0 1 1 1 0 Transposon-encoded protein TnpV Noelin-1 PF12308.8 CDW60322.1 - 0.34 10.9 1.7 0.62 10.1 1.2 1.7 2 0 0 2 2 1 0 Neurogenesis glycoprotein Phlebovirus_NSM PF07246.11 CDW60322.1 - 0.35 10.2 3.8 1.8 7.9 3.8 1.7 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DivIVA PF05103.13 CDW60322.1 - 0.51 10.4 6.2 2 8.5 6.5 1.8 1 1 1 2 2 2 0 DivIVA protein DUF1664 PF07889.12 CDW60322.1 - 0.53 10.3 4.8 0.99 9.5 4.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Uso1_p115_C PF04871.13 CDW60322.1 - 0.55 10.6 4.4 0.94 9.8 4.4 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fib_alpha PF08702.10 CDW60322.1 - 1 9.6 6.5 1.8 8.7 6.5 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 CDW60322.1 - 2 8.2 4.7 4.4 7.2 2.9 2.4 1 1 1 2 2 2 0 Septum formation initiator CYTH PF01928.21 CDW60323.1 - 3.1e-39 134.8 0.0 6e-39 133.8 0.0 1.5 1 0 0 1 1 1 1 CYTH domain DUF758 PF05527.11 CDW60323.1 - 0.0078 16.2 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF758) GlnE PF03710.15 CDW60324.1 - 2.8e-203 672.3 6.3 1.2e-102 342.6 0.5 2.7 3 0 0 3 3 3 2 Glutamate-ammonia ligase adenylyltransferase GlnD_UR_UTase PF08335.11 CDW60324.1 - 4.6e-60 201.9 6.3 2.4e-46 157.4 0.4 2.9 2 0 0 2 2 2 2 GlnD PII-uridylyltransferase PfkB PF00294.24 CDW60325.1 - 3.4e-60 203.9 0.4 5.4e-60 203.2 0.1 1.5 2 0 0 2 2 2 1 pfkB family carbohydrate kinase CTP_transf_like PF01467.26 CDW60325.1 - 2.2e-15 57.1 0.0 3.9e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Phos_pyr_kin PF08543.12 CDW60325.1 - 4e-08 32.9 0.0 9.3e-08 31.7 0.0 1.6 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 CDW60325.1 - 1.2e-05 24.9 0.1 1.9e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate kinase FAD_syn PF06574.12 CDW60325.1 - 0.055 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 FAD synthetase Pantoate_ligase PF02569.15 CDW60325.1 - 0.065 12.4 0.2 0.48 9.6 0.1 2.0 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase SPDY PF03771.16 CDW60325.1 - 0.2 11.6 0.0 0.41 10.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF317) EGF PF00008.27 CDW60326.1 - 1.8e-30 104.9 102.1 1e-06 28.9 5.2 9.0 8 0 0 8 8 8 8 EGF-like domain EGF_CA PF07645.15 CDW60326.1 - 8.4e-26 89.9 112.8 1.4e-09 38.0 10.8 8.8 6 2 2 8 8 8 5 Calcium-binding EGF domain EGF_2 PF07974.13 CDW60326.1 - 9e-17 61.2 122.0 0.00073 19.8 9.9 8.9 8 1 0 8 8 8 6 EGF-like domain hEGF PF12661.7 CDW60326.1 - 1.3e-14 54.1 103.4 2.7e-05 24.6 5.4 9.9 9 0 0 9 9 9 7 Human growth factor-like EGF EGF_3 PF12947.7 CDW60326.1 - 2.1e-06 27.8 89.9 0.0018 18.4 4.5 9.0 7 2 1 8 8 8 4 EGF domain cEGF PF12662.7 CDW60326.1 - 0.0025 17.7 1.0 0.0025 17.7 1.0 8.2 7 1 1 8 8 8 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 CDW60326.1 - 1.6 9.1 92.0 1 9.7 4.0 8.9 4 2 4 8 8 8 0 Coagulation Factor Xa inhibitory site SUI1 PF01253.22 CDW60327.1 - 2e-24 85.9 1.5 2.6e-24 85.6 1.5 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF5049 PF16468.5 CDW60327.1 - 0.031 14.2 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5049) Histone PF00125.24 CDW60328.1 - 7.9e-33 113.6 1.0 1.2e-32 113.1 1.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW60328.1 - 0.061 13.4 0.1 0.14 12.3 0.1 1.5 1 1 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DUF743 PF05332.11 CDW60328.1 - 0.12 12.5 0.5 0.66 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF743) BTB_2 PF02214.22 CDW60330.1 - 2.6e-09 37.3 0.0 5.8e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-CCHC PF00098.23 CDW60330.1 - 5.1e-07 29.5 2.3 1.3e-06 28.2 2.3 1.7 1 0 0 1 1 1 1 Zinc knuckle RVT_1 PF00078.27 CDW60330.1 - 0.0042 16.6 0.0 0.013 15.0 0.0 1.8 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC_4 PF14392.6 CDW60330.1 - 0.23 11.2 1.4 0.61 9.9 1.4 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 CDW60330.1 - 0.31 10.9 2.6 0.72 9.7 2.6 1.6 1 0 0 1 1 1 0 Zinc knuckle UPF0016 PF01169.19 CDW60331.1 - 1.5e-42 143.8 19.0 9.9e-22 77.1 3.0 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 TerC PF03741.16 CDW60331.1 - 0.00059 19.6 5.5 0.00064 19.5 0.6 2.1 2 0 0 2 2 2 1 Integral membrane protein TerC family CobD_Cbib PF03186.13 CDW60331.1 - 0.0019 17.5 0.2 0.0019 17.5 0.2 1.9 2 0 0 2 2 2 1 CobD/Cbib protein FA_desaturase PF00487.24 CDW60331.1 - 3 7.6 5.6 7 6.4 2.2 2.0 1 1 1 2 2 2 0 Fatty acid desaturase GIT_CC PF16559.5 CDW60333.1 - 0.52 10.2 4.0 0.2 11.5 0.4 2.1 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor HMA PF00403.26 CDW60334.1 - 3e-07 30.8 0.0 4.2e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Heavy-metal-associated domain zn-ribbon_14 PF16503.5 CDW60334.1 - 0.38 10.3 0.4 0.38 10.3 0.4 2.5 3 0 0 3 3 3 0 Zinc-ribbon DUF5641 PF18701.1 CDW60336.1 - 7.1e-10 38.9 0.0 1.1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Integrase_H2C2 PF17921.1 CDW60337.1 - 0.0066 16.5 3.6 0.008 16.3 1.0 2.4 2 0 0 2 2 2 1 Integrase zinc binding domain LuxT_C PF18285.1 CDW60337.1 - 0.19 12.3 2.4 28 5.3 0.1 3.1 3 0 0 3 3 3 0 Tetracycline repressor LuxT C-terminal domain PLDc_2 PF13091.6 CDW60338.1 - 3.1e-05 23.9 0.0 6.5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 PLD-like domain PLDc PF00614.22 CDW60338.1 - 0.031 14.5 0.1 0.076 13.2 0.1 1.7 1 0 0 1 1 1 0 Phospholipase D Active site motif RBD PF02196.15 CDW60339.1 - 3.2e-21 75.2 0.1 5.6e-21 74.4 0.1 1.4 1 0 0 1 1 1 1 Raf-like Ras-binding domain PAP1 PF08601.10 CDW60339.1 - 4.2 7.0 8.5 2.1 8.0 6.9 1.3 1 1 0 1 1 1 0 Transcription factor PAP1 DUF775 PF05603.12 CDW60340.1 - 2.4e-34 118.6 2.4 1.1e-33 116.5 2.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF775) EGF_2 PF07974.13 CDW60341.1 - 3e-06 27.5 64.7 0.0073 16.7 9.7 5.4 5 0 0 5 5 5 4 EGF-like domain EGF PF00008.27 CDW60341.1 - 6.8e-05 23.1 10.7 6.8e-05 23.1 10.7 6.6 6 2 0 6 6 6 3 EGF-like domain Pkinase_Tyr PF07714.17 CDW60342.1 - 5.7e-23 81.5 0.0 7.9e-23 81.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW60342.1 - 1.3e-22 80.4 0.0 1.8e-22 80.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain EST1_DNA_bind PF10373.9 CDW60343.1 - 1.4e-11 44.4 2.1 2.3e-11 43.7 2.1 1.3 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 CDW60343.1 - 6.5e-06 26.8 1.9 8.7e-06 26.4 0.2 2.2 2 0 0 2 2 2 1 Telomerase activating protein Est1 Cys_rich_FGFR PF00839.17 CDW60344.1 - 1.9e-40 136.8 16.1 1.6e-15 57.0 0.7 5.4 5 0 0 5 5 5 5 Cysteine rich repeat CX9C PF16860.5 CDW60344.1 - 0.03 14.3 2.9 0.22 11.5 0.1 3.6 3 0 0 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, PI-PLC-X PF00388.19 CDW60345.1 - 1.8e-58 196.3 0.1 4.3e-58 195.0 0.1 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain SH2 PF00017.24 CDW60345.1 - 9.8e-35 118.5 1.4 2.4e-20 72.4 0.4 2.5 2 0 0 2 2 2 2 SH2 domain PI-PLC-Y PF00387.19 CDW60345.1 - 9.8e-27 93.6 0.0 2.3e-26 92.4 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain PH PF00169.29 CDW60345.1 - 5.8e-07 30.0 0.2 0.024 15.1 0.0 3.0 3 0 0 3 3 3 2 PH domain SH3_1 PF00018.28 CDW60345.1 - 0.0001 21.9 0.0 0.00031 20.3 0.0 1.8 1 0 0 1 1 1 1 SH3 domain EF-hand_like PF09279.11 CDW60345.1 - 0.00021 21.7 0.2 0.00059 20.3 0.2 1.7 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like SH3_9 PF14604.6 CDW60345.1 - 0.0014 18.4 0.0 0.0037 17.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain AMP-binding PF00501.28 CDW60346.1 - 5.1e-61 206.5 0.1 6.4e-61 206.2 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CDW60346.1 - 1.5e-18 67.5 0.8 2.4e-18 66.9 0.8 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF1758 PF05585.12 CDW60349.1 - 2.1e-09 37.3 0.0 7.6e-09 35.5 0.0 1.9 2 0 0 2 2 2 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 CDW60349.1 - 0.025 15.2 0.0 0.07 13.8 0.0 1.9 1 1 0 1 1 1 0 Aspartyl protease SelA PF03841.13 CDW60350.1 - 1.5e-158 527.6 1.1 1.8e-158 527.3 1.1 1.1 1 0 0 1 1 1 1 L-seryl-tRNA selenium transferase Beta_elim_lyase PF01212.21 CDW60350.1 - 2.4e-06 27.0 0.0 5.9e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CDW60350.1 - 2.7e-05 23.3 0.7 0.00011 21.3 0.7 1.8 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CDW60350.1 - 3e-05 22.8 0.4 0.00011 20.9 0.2 2.0 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CDW60350.1 - 0.00047 19.6 0.2 0.0011 18.3 0.1 1.6 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Se-cys_synth_N PF12390.8 CDW60350.1 - 0.087 13.1 0.2 0.39 11.0 0.0 2.3 2 0 0 2 2 2 0 Selenocysteine synthase N terminal ABC_tran PF00005.27 CDW60352.1 - 8e-35 120.3 0.1 1.2e-34 119.8 0.1 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW60352.1 - 3.8e-05 23.6 2.1 0.21 11.4 0.8 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW60352.1 - 4.4e-05 23.1 0.1 8.8e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDW60352.1 - 9.3e-05 22.4 0.5 0.00021 21.2 0.5 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDW60352.1 - 0.00026 21.4 0.4 0.0005 20.5 0.3 1.6 1 1 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 CDW60352.1 - 0.00087 18.8 0.9 0.0034 16.8 0.9 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDW60352.1 - 0.0018 18.6 0.4 0.063 13.5 0.2 2.6 1 1 1 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CDW60352.1 - 0.0055 16.8 0.0 0.013 15.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 CDW60352.1 - 0.0062 17.1 0.0 0.013 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CDW60352.1 - 0.016 15.1 1.9 4 7.3 0.1 2.6 1 1 2 3 3 3 0 Adenylylsulphate kinase IstB_IS21 PF01695.17 CDW60352.1 - 0.022 14.5 0.2 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein Rad17 PF03215.15 CDW60352.1 - 0.026 14.4 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 CDW60352.1 - 0.028 14.7 0.0 0.07 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 CDW60352.1 - 0.035 13.8 0.3 0.1 12.3 0.3 1.7 1 1 0 1 1 1 0 AAA domain THF_DHG_CYH PF00763.23 CDW60352.1 - 0.039 14.2 0.0 11 6.4 0.0 2.9 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain T2SSE PF00437.20 CDW60352.1 - 0.061 12.4 0.1 0.15 11.1 0.1 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_23 PF13476.6 CDW60352.1 - 0.067 13.7 1.2 0.089 13.3 1.0 1.7 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 CDW60352.1 - 0.068 12.1 0.1 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 CDW60352.1 - 0.089 12.4 0.1 0.35 10.4 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 CDW60352.1 - 0.092 12.3 0.5 0.38 10.3 0.2 2.0 1 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CDW60352.1 - 0.093 12.8 0.5 0.72 9.9 0.0 2.3 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 CDW60352.1 - 0.11 11.8 0.1 0.22 10.8 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family CSD PF00313.22 CDW60353.1 - 2.4e-28 97.8 2.7 4e-28 97.1 2.7 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain DUF1905 PF08922.11 CDW60353.1 - 3.2e-21 75.2 0.0 5.3e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1905) Serpin PF00079.20 CDW60354.1 - 3.6e-116 388.5 8.9 1.9e-92 310.4 5.6 2.0 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) SepSecS PF05889.13 CDW60356.1 - 3.5e-116 388.1 0.0 4.9e-116 387.6 0.0 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS CNRIP1 PF15043.6 CDW60356.1 - 4.7e-11 42.5 0.0 9.6e-11 41.5 0.0 1.5 1 0 0 1 1 1 1 CB1 cannabinoid receptor-interacting protein 1 Beta_elim_lyase PF01212.21 CDW60356.1 - 0.0037 16.6 0.0 0.0047 16.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase WD40_4 PF16300.5 CDW60357.1 - 2.3e-19 69.0 0.1 6.3e-19 67.6 0.1 1.7 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.32 CDW60357.1 - 0.00025 21.8 0.1 0.011 16.6 0.0 3.3 4 0 0 4 4 4 1 WD domain, G-beta repeat CAT_RBD PF03123.15 CDW60357.1 - 0.0069 16.3 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 CAT RNA binding domain Toluene_X PF03349.16 CDW60360.1 - 0.091 11.3 0.0 0.17 10.4 0.0 1.4 2 0 0 2 2 2 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) PSD1 PF07587.11 CDW60365.1 - 0.074 12.5 0.1 0.11 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) Peptidase_M1 PF01433.20 CDW60367.1 - 4.7e-61 206.1 5.4 8.3e-53 179.2 5.0 2.7 2 1 0 2 2 2 2 Peptidase family M1 domain ERAP1_C PF11838.8 CDW60367.1 - 1.1e-57 196.0 0.0 1.6e-57 195.4 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain CS PF04969.16 CDW60369.1 - 0.021 15.8 3.7 2.2 9.4 1.3 2.7 2 1 0 2 2 2 0 CS domain FDF PF09532.10 CDW60369.1 - 0.051 14.5 3.6 0.12 13.3 3.6 1.6 1 0 0 1 1 1 0 FDF domain Mis14 PF08641.12 CDW60370.1 - 0.019 15.3 0.2 0.022 15.1 0.2 1.2 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Golgin_A5 PF09787.9 CDW60370.1 - 0.061 12.8 0.1 0.067 12.7 0.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF2508 PF10704.9 CDW60370.1 - 0.11 12.6 1.0 0.15 12.3 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) Histone_H2A_C PF16211.5 CDW60371.1 - 3.7e-18 65.0 0.1 7.9e-18 63.9 0.1 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW60371.1 - 5.1e-16 59.2 0.0 6.8e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW60371.1 - 2e-05 24.8 0.0 2.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RT_RNaseH_2 PF17919.1 CDW60374.1 - 3.9e-07 30.0 0.0 4.8e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase DNA_photolyase PF00875.18 CDW60374.1 - 0.047 13.7 0.0 0.053 13.5 0.0 1.1 1 0 0 1 1 1 0 DNA photolyase RT_RNaseH PF17917.1 CDW60374.1 - 0.15 12.3 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CDW60375.1 - 4.9e-06 26.2 0.0 5e-06 26.2 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Mito_carr PF00153.27 CDW60379.1 - 9.8e-56 185.7 2.4 3.9e-19 68.4 0.0 4.6 3 1 1 4 4 4 4 Mitochondrial carrier protein EGF PF00008.27 CDW60380.1 - 9.2e-40 134.6 165.8 2.2e-07 31.0 9.6 11.6 11 0 0 11 11 11 10 EGF-like domain EGF_CA PF07645.15 CDW60380.1 - 1.2e-24 86.2 173.5 2e-08 34.3 13.1 10.9 4 2 6 10 10 10 8 Calcium-binding EGF domain hEGF PF12661.7 CDW60380.1 - 2.1e-20 72.6 136.3 0.00019 21.9 7.2 12.3 11 0 0 11 11 11 9 Human growth factor-like EGF EGF_2 PF07974.13 CDW60380.1 - 2.6e-15 56.5 187.3 0.003 17.9 13.0 11.1 11 0 0 11 11 11 8 EGF-like domain FXa_inhibition PF14670.6 CDW60380.1 - 1.4e-08 34.8 143.3 0.063 13.6 10.3 11.2 6 3 5 11 11 11 6 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW60380.1 - 4.4e-07 30.0 174.4 0.00031 20.9 14.3 12.3 10 1 1 11 11 11 8 EGF domain DUF2207 PF09972.9 CDW60381.1 - 0.016 14.0 0.1 0.017 13.9 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1240 PF06836.12 CDW60381.1 - 0.17 12.4 2.0 0.81 10.3 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1240) EGF PF00008.27 CDW60382.1 - 8e-41 138.0 137.2 1.9e-07 31.2 8.0 9.4 9 0 0 9 9 9 8 EGF-like domain EGF_CA PF07645.15 CDW60382.1 - 1.6e-23 82.6 151.3 5.8e-10 39.2 10.4 9.5 3 2 6 9 9 9 7 Calcium-binding EGF domain hEGF PF12661.7 CDW60382.1 - 3.5e-23 81.3 111.3 6e-05 23.5 4.7 10.8 9 1 0 9 9 9 8 Human growth factor-like EGF EGF_2 PF07974.13 CDW60382.1 - 1.4e-17 63.8 157.3 0.00064 20.0 13.2 9.4 9 0 0 9 9 9 8 EGF-like domain FXa_inhibition PF14670.6 CDW60382.1 - 1.6e-07 31.4 127.4 0.015 15.6 9.2 9.7 4 1 5 9 9 9 6 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW60382.1 - 9.2e-07 29.0 23.5 6.6e-05 23.0 10.1 10.5 8 1 1 9 9 9 7 EGF domain Plasmod_Pvs28 PF06247.11 CDW60382.1 - 0.031 14.6 9.1 0.031 14.6 9.1 9.2 8 1 1 9 9 9 0 Pvs28 EGF domain Aldedh PF00171.22 CDW60383.1 - 2e-75 254.1 0.0 1.1e-74 251.6 0.0 1.8 1 1 0 1 1 1 1 Aldehyde dehydrogenase family NAPRTase PF04095.16 CDW60384.1 - 1.2e-59 201.9 0.0 1.4e-59 201.6 0.0 1.0 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family His_Phos_2 PF00328.22 CDW60385.1 - 8.1e-09 35.3 0.6 2.4e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) XendoU PF09412.10 CDW60386.1 - 9.8e-75 251.2 0.0 1.2e-74 250.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU EndoU_bacteria PF14436.6 CDW60386.1 - 0.07 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial EndoU nuclease RVT_1 PF00078.27 CDW60387.1 - 0.0083 15.7 0.0 0.0087 15.6 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) HTH_Tnp_IS1 PF12759.7 CDW60387.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 InsA C-terminal domain PDZ_6 PF17820.1 CDW60388.1 - 0.00013 21.8 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 CDW60388.1 - 0.0024 18.2 0.1 0.0033 17.7 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW60388.1 - 0.013 15.8 0.1 0.02 15.2 0.1 1.3 1 0 0 1 1 1 0 PDZ domain Tricorn_PDZ PF14685.6 CDW60388.1 - 0.15 12.1 0.1 0.31 11.0 0.0 1.6 2 0 0 2 2 2 0 Tricorn protease PDZ domain Y_phosphatase PF00102.27 CDW60389.1 - 2.1e-39 135.5 0.0 4.1e-39 134.5 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Ank_2 PF12796.7 CDW60390.1 - 4.8e-17 62.3 2.4 5e-12 46.3 0.4 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CDW60390.1 - 2e-15 56.4 3.2 1.4e-05 25.3 0.4 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 CDW60390.1 - 6.3e-15 55.0 0.4 2.2e-06 27.8 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CDW60390.1 - 7.6e-13 48.7 1.2 6.4e-05 23.4 0.1 3.2 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW60390.1 - 9.3e-11 41.0 1.0 0.00046 20.4 0.1 4.1 4 0 0 4 4 4 2 Ankyrin repeat CENP-B_N PF04218.13 CDW60391.1 - 1.5e-09 37.3 2.9 3.6e-09 36.1 2.9 1.7 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.16 CDW60391.1 - 2.8e-07 30.5 0.0 5.8e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_23 PF13384.6 CDW60391.1 - 0.0019 18.0 0.1 0.0046 16.7 0.1 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 CDW60391.1 - 0.06 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DER1 PF04511.15 CDW60393.1 - 3.2e-58 196.8 21.3 6.6e-57 192.5 21.3 2.0 1 1 0 1 1 1 1 Der1-like family ubiquitin PF00240.23 CDW60394.1 - 4.1e-06 26.4 0.0 7.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CDW60394.1 - 0.018 15.1 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CDW60394.1 - 0.1 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain CAP PF00188.26 CDW60395.1 - 4.4e-24 85.7 2.5 4.4e-24 85.7 2.5 1.6 2 0 0 2 2 2 1 Cysteine-rich secretory protein family ShK PF01549.24 CDW60395.1 - 2.2e-08 34.5 10.6 2.2e-08 34.5 10.6 3.1 3 0 0 3 3 3 1 ShK domain-like UPF0203 PF05254.12 CDW60395.1 - 0.019 15.2 1.2 0.05 13.8 1.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0203) VitD-bind_III PF09164.10 CDW60395.1 - 0.042 13.9 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Tubulin PF00091.25 CDW60396.1 - 1.1e-68 231.4 0.0 1.6e-68 230.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CDW60396.1 - 4.5e-43 146.4 0.0 7.1e-43 145.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CDW60396.1 - 2.5e-05 24.5 0.0 5.9e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 CDW60396.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 CDW60396.1 - 0.017 14.3 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 Tubulin like DuoxA PF10204.9 CDW60397.1 - 3.4e-28 98.5 0.0 3.9e-28 98.3 0.0 1.0 1 0 0 1 1 1 1 Dual oxidase maturation factor ZapA PF05164.13 CDW60398.1 - 5e-20 71.7 1.5 6.5e-20 71.4 1.5 1.1 1 0 0 1 1 1 1 Cell division protein ZapA DUF3482 PF11981.8 CDW60398.1 - 0.0015 18.0 5.1 0.0018 17.7 5.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3482) Bac_rhamnosid6H PF17389.2 CDW60398.1 - 0.024 13.9 0.3 0.027 13.7 0.3 1.0 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain PEP-utilisers_N PF05524.13 CDW60398.1 - 0.076 13.2 3.1 0.13 12.4 3.1 1.4 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF2205 PF10224.9 CDW60398.1 - 0.13 12.3 3.5 1.5 8.9 0.1 2.2 2 0 0 2 2 2 0 Short coiled-coil protein DUF5320 PF17253.2 CDW60398.1 - 0.73 10.9 3.9 13 7.0 0.2 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5320) 5-FTHF_cyc-lig PF01812.20 CDW60399.1 - 5.3e-45 153.6 0.0 6.7e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family PRP3 PF08572.10 CDW60399.1 - 0.1 12.3 0.7 0.17 11.6 0.7 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 3 (PRP3) 2-Hacid_dh_C PF02826.19 CDW60400.1 - 1.5e-50 171.0 0.0 2.9e-50 170.1 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDW60400.1 - 6.5e-39 132.7 0.0 1e-38 132.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ACT PF01842.25 CDW60400.1 - 1e-07 31.6 0.1 5.7e-07 29.2 0.0 2.1 2 0 0 2 2 2 1 ACT domain NAD_binding_2 PF03446.15 CDW60400.1 - 3.2e-05 24.1 0.5 0.00036 20.7 0.0 2.6 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT_4 PF13291.6 CDW60400.1 - 0.03 14.9 0.0 0.075 13.6 0.0 1.6 1 0 0 1 1 1 0 ACT domain 3HCDH_N PF02737.18 CDW60400.1 - 0.035 14.0 0.4 1.3 8.9 0.0 2.8 2 1 1 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 CDW60400.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain XdhC_C PF13478.6 CDW60400.1 - 0.14 12.7 0.1 1.8 9.1 0.0 2.6 3 0 0 3 3 3 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 CDW60400.1 - 0.2 11.0 1.2 1.3 8.3 0.1 2.4 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PI-TkoII_IV PF18714.1 CDW60400.1 - 0.21 11.0 0.0 0.58 9.6 0.0 1.7 2 0 0 2 2 2 0 DNA polymerase II intein Domain IV Rib_5-P_isom_A PF06026.14 CDW60401.1 - 3.1e-59 199.5 0.3 3.6e-59 199.2 0.3 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CDW60401.1 - 0.00013 22.0 0.1 0.0013 18.7 0.0 2.2 2 0 0 2 2 2 1 DeoR C terminal sensor domain HTH_1 PF00126.27 CDW60402.1 - 7.5e-19 67.4 1.5 1.1e-18 66.9 0.1 2.1 3 0 0 3 3 3 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CDW60402.1 - 8.4e-12 44.9 1.3 1.3e-11 44.2 1.3 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_30 PF13556.6 CDW60402.1 - 0.036 13.9 0.0 0.079 12.8 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain MM_CoA_mutase PF01642.22 CDW60403.1 - 1e-236 786.4 0.5 1.2e-236 786.2 0.5 1.1 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 CDW60403.1 - 4.1e-16 59.1 0.8 8.2e-16 58.1 0.1 1.9 2 0 0 2 2 2 1 B12 binding domain sCache_like PF16736.5 CDW60403.1 - 0.0019 18.3 1.4 0.0037 17.3 1.2 1.6 1 1 0 1 1 1 1 Single Cache-like RE_Eco29kI PF09517.10 CDW60403.1 - 0.053 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Eco29kI restriction endonuclease TetR_C_11 PF16859.5 CDW60403.1 - 0.11 12.8 4.2 0.12 12.7 2.1 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MeaB PF03308.16 CDW60404.1 - 4.7e-116 386.4 0.2 5.9e-116 386.1 0.2 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ECH_1 PF00378.20 CDW60404.1 - 2.9e-39 134.9 0.0 4.4e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CDW60404.1 - 2.4e-17 63.4 0.0 5.8e-15 55.6 0.0 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase cobW PF02492.19 CDW60404.1 - 9.5e-06 25.3 2.7 0.00014 21.5 1.3 3.1 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 CDW60404.1 - 8.2e-05 22.7 0.0 0.00013 22.0 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 CDW60404.1 - 0.0022 17.8 0.0 0.005 16.7 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.17 CDW60404.1 - 0.0046 16.7 0.1 0.023 14.4 0.0 2.2 2 1 1 3 3 3 1 IstB-like ATP binding protein AAA_29 PF13555.6 CDW60404.1 - 0.0085 15.8 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 CDW60404.1 - 0.013 15.2 0.4 0.04 13.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CDW60404.1 - 0.015 15.6 1.1 0.28 11.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 CDW60404.1 - 0.028 14.1 0.0 0.075 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CDW60404.1 - 0.046 14.1 0.2 2.7 8.4 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain KTI12 PF08433.10 CDW60404.1 - 0.048 13.1 0.1 3.5 7.0 0.0 3.0 3 0 0 3 3 3 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 CDW60404.1 - 0.049 13.5 0.3 0.16 11.9 0.0 2.0 2 0 0 2 2 1 0 NTPase RsgA_GTPase PF03193.16 CDW60404.1 - 0.079 12.9 0.1 8.1 6.3 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase SRP54 PF00448.22 CDW60404.1 - 0.079 12.6 0.0 3.3 7.3 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 CDW60404.1 - 0.086 13.4 0.5 0.25 11.9 0.1 2.0 2 1 0 2 2 2 0 AAA domain PRK PF00485.18 CDW60404.1 - 0.086 12.6 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATPase PF06745.13 CDW60404.1 - 0.096 12.0 0.5 0.22 10.8 0.1 1.7 2 0 0 2 2 2 0 KaiC MobB PF03205.14 CDW60404.1 - 0.098 12.6 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AcetylCoA_hydro PF02550.15 CDW60405.1 - 7e-77 257.9 0.0 8.3e-77 257.7 0.0 1.0 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain CoA_trans PF01144.23 CDW60405.1 - 0.0083 15.6 0.0 0.027 13.8 0.0 1.8 2 0 0 2 2 2 1 Coenzyme A transferase LUD_dom PF02589.15 CDW60405.1 - 0.088 12.5 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 LUD domain SusD-like_2 PF12771.7 CDW60405.1 - 0.16 10.8 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Starch-binding associating with outer membrane TF_Zn_Ribbon PF08271.12 CDW60406.1 - 0.023 14.2 0.0 0.057 12.9 0.0 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding EarP PF10093.9 CDW60406.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Elongation-Factor P (EF-P) rhamnosyltransferase EarP Retrotran_gag_2 PF14223.6 CDW60407.1 - 4e-09 36.2 0.1 5.7e-09 35.8 0.1 1.2 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type zf-CCHC_4 PF14392.6 CDW60407.1 - 0.00037 20.2 0.3 0.00081 19.1 0.3 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 CDW60407.1 - 0.00052 20.0 2.1 0.00082 19.3 2.1 1.3 1 0 0 1 1 1 1 Zinc knuckle CTV_P23 PF04808.12 CDW60407.1 - 0.0026 17.3 0.3 0.0042 16.6 0.0 1.5 2 0 0 2 2 2 1 Citrus tristeza virus (CTV) P23 protein MAP65_ASE1 PF03999.12 CDW60408.1 - 5.9e-37 127.7 26.9 8.6e-31 107.3 15.9 2.0 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) WD40 PF00400.32 CDW60410.1 - 8.8e-13 48.5 11.3 0.37 11.8 0.2 5.5 4 1 1 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW60410.1 - 0.00072 19.8 0.2 0.5 10.7 0.1 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Histone PF00125.24 CDW60411.1 - 7.6e-50 168.7 2.2 8.5e-50 168.5 2.2 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW60411.1 - 0.00011 22.8 1.1 0.00015 22.4 1.1 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW60411.1 - 0.00081 19.5 0.2 0.0015 18.6 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW60411.1 - 0.003 17.9 0.0 0.0051 17.2 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW60411.1 - 0.036 14.1 0.1 0.073 13.2 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW60411.1 - 0.051 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LVIVD PF08309.11 CDW60412.1 - 0.084 12.2 0.8 0.15 11.4 0.8 1.3 1 0 0 1 1 1 0 LVIVD repeat Trypsin PF00089.26 CDW60413.1 - 2.3e-55 187.8 1.3 5.4e-45 153.9 0.6 2.1 2 0 0 2 2 2 2 Trypsin Trypsin_2 PF13365.6 CDW60413.1 - 2.3e-06 28.6 0.1 0.00039 21.3 0.0 2.4 2 0 0 2 2 2 2 Trypsin-like peptidase domain DUF316 PF03761.15 CDW60413.1 - 0.014 15.0 0.1 0.023 14.3 0.1 1.3 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 zf-CCHC_5 PF14787.6 CDW60414.1 - 0.0011 18.6 4.9 0.0029 17.3 4.9 1.7 1 0 0 1 1 1 1 GAG-polyprotein viral zinc-finger Asp_protease_2 PF13650.6 CDW60415.1 - 0.00016 22.2 0.1 0.00036 21.1 0.1 1.8 1 1 0 1 1 1 1 Aspartyl protease DUF1758 PF05585.12 CDW60415.1 - 0.00041 20.2 0.0 0.00048 19.9 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase (DUF1758) gag-asp_proteas PF13975.6 CDW60415.1 - 0.0025 18.3 0.0 0.022 15.3 0.0 2.0 1 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease Carboxyl_trans PF01039.22 CDW60416.1 - 1.4e-147 492.3 0.0 1.8e-147 492.0 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CDW60416.1 - 0.0001 21.9 0.6 0.0046 16.5 0.1 2.2 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) CLPTM1 PF05602.12 CDW60418.1 - 6.9e-76 256.0 3.5 8.7e-76 255.7 3.5 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 CDW60418.1 - 0.00053 19.7 4.7 0.23 11.3 0.6 2.9 2 0 0 2 2 2 2 PQ loop repeat RPN7 PF10602.9 CDW60419.1 - 2.9e-31 108.5 3.3 5.5e-31 107.6 3.3 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CDW60419.1 - 1.2e-10 41.8 0.3 1.2e-10 41.8 0.3 2.5 4 0 0 4 4 4 1 PCI domain TPR_2 PF07719.17 CDW60419.1 - 0.0026 17.7 0.2 0.74 10.1 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDW60419.1 - 0.0047 16.9 0.2 1.3 9.2 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CDW60419.1 - 0.0082 15.9 0.2 0.34 10.8 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DDRGK PF09756.9 CDW60419.1 - 0.11 12.1 0.3 0.25 10.9 0.3 1.6 1 0 0 1 1 1 0 DDRGK domain TPR_3 PF07720.12 CDW60419.1 - 0.44 10.6 2.0 1.5 8.9 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat L-fibroin PF05849.11 CDW60420.1 - 0.059 12.7 0.3 0.078 12.3 0.3 1.1 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) YkuD PF03734.14 CDW60421.1 - 4.3e-16 59.6 0.2 7.4e-16 58.9 0.2 1.3 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain PG_binding_1 PF01471.18 CDW60421.1 - 7.2e-10 38.9 0.3 4.8e-07 29.9 0.0 3.2 3 0 0 3 3 3 2 Putative peptidoglycan binding domain DUF4389 PF14333.6 CDW60421.1 - 0.073 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) MukB PF04310.12 CDW60422.1 - 4.7e-95 317.7 0.0 4.7e-95 317.7 0.0 2.9 3 0 0 3 3 3 1 MukB N-terminal MukB_hinge PF16330.5 CDW60422.1 - 5.6e-74 247.4 0.1 5.6e-74 247.4 0.1 4.0 3 1 1 4 4 4 1 MukB hinge domain SbcCD_C PF13558.6 CDW60422.1 - 2.6e-15 56.4 0.0 8.4e-15 54.8 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit KIX PF02172.16 CDW60422.1 - 0.021 15.1 3.1 7.4 6.9 0.2 4.1 3 0 0 3 3 3 0 KIX domain DUF1759 PF03564.15 CDW60422.1 - 1.2 9.1 10.6 0.8 9.6 0.4 4.6 4 1 1 5 5 5 0 Protein of unknown function (DUF1759) MukE PF04288.13 CDW60423.1 - 1e-123 410.7 0.2 1.8e-123 409.9 0.2 1.4 1 0 0 1 1 1 1 MukE-like family MukF_M PF17192.4 CDW60423.1 - 1.6e-84 281.5 5.8 1.6e-84 281.5 5.8 2.0 2 0 0 2 2 1 1 MukF middle domain MukF_C PF17193.4 CDW60423.1 - 2.6e-74 248.7 0.8 2.6e-74 248.7 0.8 1.9 2 0 0 2 2 1 1 MukF C-terminal domain KicB PF03882.14 CDW60423.1 - 1.4e-55 186.5 0.1 4.1e-55 184.9 0.1 1.8 1 0 0 1 1 1 1 MukF winged-helix domain Methyltransf_31 PF13847.6 CDW60423.1 - 1.4e-18 67.2 0.0 7.1e-18 64.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW60423.1 - 1.1e-17 64.5 0.1 4.9e-17 62.4 0.1 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW60423.1 - 1.9e-17 63.6 0.0 4.9e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW60423.1 - 8.2e-17 61.6 0.0 2.3e-16 60.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW60423.1 - 2.7e-15 56.9 0.0 2.1e-14 54.1 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CDW60423.1 - 8.6e-10 38.3 0.0 1.6e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_15 PF09445.10 CDW60423.1 - 1.1e-05 25.0 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 CDW60423.1 - 1.3e-05 24.8 0.1 2.8e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 CDW60423.1 - 0.00011 23.2 0.0 0.00062 20.8 0.1 2.3 2 0 0 2 2 1 1 Methyltransferase domain DREV PF05219.12 CDW60423.1 - 0.00076 18.6 0.0 0.0015 17.7 0.0 1.4 1 0 0 1 1 1 1 DREV methyltransferase DUF4194 PF13835.6 CDW60423.1 - 0.0013 18.5 2.2 0.16 11.7 0.6 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4194) CMAS PF02353.20 CDW60423.1 - 0.0015 17.9 0.0 0.0033 16.8 0.0 1.5 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 CDW60423.1 - 0.003 17.5 0.1 0.0077 16.2 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 CDW60423.1 - 0.03 14.0 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) rRNA_methylase PF06962.12 CDW60423.1 - 0.055 13.4 0.1 0.68 9.9 0.1 2.4 1 1 0 1 1 1 0 Putative rRNA methylase Tfb2 PF03849.14 CDW60423.1 - 0.092 11.7 0.0 0.23 10.4 0.0 1.6 2 0 0 2 2 2 0 Transcription factor Tfb2 UPF0020 PF01170.18 CDW60423.1 - 0.12 12.0 0.0 0.34 10.6 0.0 1.7 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 DUF218 PF02698.17 CDW60424.1 - 4.2e-28 98.0 0.0 5.1e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 DUF218 domain Retrotran_gag_3 PF14244.6 CDW60425.1 - 0.032 14.0 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 CDW60425.1 - 0.6 9.8 0.0 0.6 9.8 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4219) tRNA_U5-meth_tr PF05958.11 CDW60426.1 - 8.5e-21 74.3 2.7 4.3e-19 68.7 2.7 2.7 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.20 CDW60426.1 - 1.1e-08 34.9 0.3 3.1e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 TRAM domain Methyltransf_31 PF13847.6 CDW60426.1 - 1.1e-07 31.7 0.0 7e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW60426.1 - 3.7e-06 27.5 0.0 2.1e-05 25.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CDW60426.1 - 3.8e-06 26.5 0.0 9.9e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 CDW60426.1 - 7.8e-05 22.4 0.0 0.00021 21.0 0.0 1.7 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 CDW60426.1 - 0.00025 20.7 0.0 0.00071 19.2 0.0 1.9 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 CDW60426.1 - 0.004 16.6 0.0 0.0073 15.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 CDW60426.1 - 0.0075 16.9 0.1 0.037 14.7 0.0 2.3 3 0 0 3 3 1 1 Methyltransferase domain UPF0020 PF01170.18 CDW60426.1 - 0.012 15.3 0.4 0.092 12.4 0.1 2.4 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 Met_10 PF02475.16 CDW60426.1 - 0.021 14.6 0.1 0.042 13.6 0.1 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Ubie_methyltran PF01209.18 CDW60426.1 - 0.024 14.0 0.0 0.18 11.1 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 CDW60426.1 - 0.026 14.5 0.0 0.051 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 CDW60426.1 - 0.026 13.6 0.0 0.05 12.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 CDW60426.1 - 0.034 14.9 0.1 0.2 12.4 0.0 2.4 3 0 0 3 3 2 0 Methyltransferase domain TehB PF03848.14 CDW60426.1 - 0.049 13.0 0.0 0.084 12.3 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_4 PF02390.17 CDW60426.1 - 0.08 12.4 0.0 0.23 10.9 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Mistic PF11458.8 CDW60426.1 - 0.14 12.2 0.5 0.72 9.8 0.1 2.5 2 0 0 2 2 2 0 Membrane-integrating protein Mistic RecX PF02631.16 CDW60427.1 - 2.3e-29 102.3 11.7 1.3e-24 87.0 3.6 2.5 1 1 1 2 2 2 2 RecX family HhH-GPD PF00730.25 CDW60427.1 - 4.2e-19 69.0 0.0 1.1e-18 67.7 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CDW60427.1 - 1.7e-08 33.9 0.0 3.4e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif DUF494 PF04361.13 CDW60427.1 - 0.0019 18.1 4.8 0.031 14.2 0.3 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF494) HHH_2 PF12826.7 CDW60427.1 - 0.0045 17.1 0.5 5.6 7.1 0.0 3.6 4 0 0 4 4 4 2 Helix-hairpin-helix motif HHH_5 PF14520.6 CDW60427.1 - 0.0071 16.9 0.1 6.3 7.5 0.0 3.3 2 1 1 3 3 3 2 Helix-hairpin-helix domain DUF1823 PF08853.11 CDW60427.1 - 0.7 10.1 4.8 8.4 6.6 0.0 3.8 5 0 0 5 5 5 0 Domain of unknown function (DUF1823) CorC_HlyC PF03471.17 CDW60428.1 - 2.6e-20 72.2 0.9 1.1e-19 70.3 0.1 2.3 3 0 0 3 3 3 1 Transporter associated domain DUF21 PF01595.20 CDW60428.1 - 1.1e-17 64.4 0.0 1.6e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CDW60428.1 - 6.1e-14 52.2 2.0 4.7e-07 30.1 0.6 2.5 2 0 0 2 2 2 2 CBS domain Streptin-Immun PF11083.8 CDW60428.1 - 0.23 11.9 2.3 0.4 11.1 0.1 2.5 2 1 1 3 3 3 0 Lantibiotic streptin immunity protein GTP_EFTU PF00009.27 CDW60429.1 - 4.3e-50 170.0 0.0 6.2e-50 169.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RF3_C PF16658.5 CDW60429.1 - 5.3e-43 146.0 0.5 9.3e-43 145.2 0.5 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 CDW60429.1 - 3.8e-14 52.8 0.2 8.1e-14 51.8 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CDW60429.1 - 1.3e-06 28.4 0.1 3.3e-06 27.2 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CDW60429.1 - 8.7e-06 25.7 0.0 1.8e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II FeoB_N PF02421.18 CDW60429.1 - 0.019 14.5 0.0 0.55 9.8 0.1 2.9 2 1 0 2 2 2 0 Ferrous iron transport protein B SRPRB PF09439.10 CDW60429.1 - 0.021 14.3 0.2 0.17 11.3 0.2 2.2 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Gp_dh_C PF02800.20 CDW60431.1 - 4.5e-53 179.1 0.1 1e-52 177.9 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CDW60431.1 - 1.7e-34 118.2 0.2 5.1e-34 116.6 0.0 1.9 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NanE PF04131.14 CDW60431.1 - 0.023 13.9 0.4 0.17 11.1 0.1 2.2 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Semialdhyde_dhC PF02774.18 CDW60431.1 - 0.038 14.1 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain NAD_binding_3 PF03447.16 CDW60431.1 - 0.048 14.3 0.1 0.27 11.9 0.1 2.0 1 1 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CDW60431.1 - 0.075 12.4 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 CDW60431.1 - 0.1 12.9 0.8 0.51 10.6 0.2 2.3 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain GTP1_OBG PF01018.22 CDW60432.1 - 4.9e-59 198.4 5.4 7.1e-59 197.9 5.4 1.2 1 0 0 1 1 1 1 GTP1/OBG DUF1967 PF09269.11 CDW60432.1 - 3.6e-27 94.1 1.7 9.8e-27 92.7 0.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1967) MMR_HSR1 PF01926.23 CDW60432.1 - 5.3e-22 78.0 0.0 9.8e-22 77.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW60432.1 - 6.5e-09 35.5 0.0 4.2e-08 32.9 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 CDW60432.1 - 9.9e-09 34.6 0.1 1.8e-05 23.9 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 CDW60432.1 - 0.00012 21.7 0.2 0.0003 20.4 0.1 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 CDW60432.1 - 0.0002 20.9 0.0 0.0006 19.3 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 CDW60432.1 - 0.024 14.4 0.0 0.91 9.3 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1_C PF08438.10 CDW60432.1 - 0.035 14.7 0.3 0.081 13.5 0.3 1.6 1 0 0 1 1 1 0 GTPase of unknown function C-terminal RsgA_GTPase PF03193.16 CDW60432.1 - 0.042 13.8 0.2 1.7 8.5 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 CDW60432.1 - 0.051 13.3 0.0 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 CDW60432.1 - 0.15 12.7 0.1 0.86 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CDW60432.1 - 0.17 12.4 0.0 0.49 10.9 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Trans_reg_C PF00486.28 CDW60433.1 - 2.7e-09 37.0 0.1 1.4e-08 34.7 0.1 2.0 2 0 0 2 2 2 1 Transcriptional regulatory protein, C terminal DUF1269 PF06897.12 CDW60433.1 - 7.7e-05 22.9 0.6 0.00019 21.7 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1269) DUF456 PF04306.13 CDW60433.1 - 0.00016 22.0 2.0 0.00025 21.4 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF456) Lactamase_B_2 PF12706.7 CDW60434.1 - 2.9e-16 59.6 0.0 1.3e-08 34.6 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CDW60434.1 - 1.1e-10 41.8 0.0 1.8e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 CDW60434.1 - 1.3e-05 24.7 0.0 3.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 tRNase Z endonuclease PDEase_II PF02112.15 CDW60434.1 - 0.11 11.6 0.0 0.31 10.1 0.0 1.7 2 0 0 2 2 2 0 cAMP phosphodiesterases class-II adh_short PF00106.25 CDW60435.1 - 7.4e-54 182.2 0.5 9.6e-54 181.8 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CDW60435.1 - 7.8e-33 114.0 0.1 1.1e-32 113.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CDW60435.1 - 3.4e-10 40.1 0.1 3.9e-10 39.9 0.1 1.1 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 CDW60435.1 - 0.006 15.7 0.1 0.0079 15.3 0.1 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CDW60435.1 - 0.015 14.7 0.1 0.023 14.2 0.1 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CDW60435.1 - 0.053 12.9 0.0 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CDW60435.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding ssDNA-exonuc_C PF10141.9 CDW60436.1 - 2e-53 181.0 4.1 3.3e-53 180.4 4.1 1.3 1 0 0 1 1 1 1 Single-strand DNA-specific exonuclease, C terminal domain RecJ_OB PF17768.1 CDW60436.1 - 9.1e-28 96.7 0.2 2.3e-27 95.4 0.2 1.7 1 0 0 1 1 1 1 RecJ OB domain DHHA1 PF02272.19 CDW60436.1 - 6.4e-15 55.8 0.0 1.8e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 CDW60436.1 - 1.6e-10 41.1 0.0 3e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 DHH family BsuPI PF12690.7 CDW60436.1 - 0.11 12.6 0.1 0.51 10.4 0.0 2.0 2 0 0 2 2 2 0 Intracellular proteinase inhibitor Pribosyltran PF00156.27 CDW60437.1 - 0.00076 19.0 0.0 0.00083 18.9 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pkinase PF00069.25 CDW60438.1 - 2.9e-57 194.0 0.0 3.3e-57 193.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60438.1 - 3.3e-26 92.1 0.0 3.8e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW60438.1 - 1.4e-06 27.9 0.0 0.00061 19.2 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 CDW60438.1 - 6.6e-06 25.3 0.1 8e-06 25.0 0.1 1.0 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CDW60438.1 - 1.3e-05 24.6 0.2 2.6e-05 23.7 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CDW60438.1 - 0.00029 19.8 0.0 0.00043 19.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CDW60438.1 - 0.0056 16.6 0.1 0.033 14.1 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CDW60438.1 - 0.014 15.0 0.1 0.037 13.6 0.0 1.6 2 0 0 2 2 2 0 RIO1 family FTA2 PF13095.6 CDW60438.1 - 0.1 12.2 0.1 0.72 9.4 0.1 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 MiAMP1 PF09117.10 CDW60438.1 - 0.13 12.6 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 MiAMP1 UPF0004 PF00919.20 CDW60439.1 - 3.9e-17 62.1 0.2 3.3e-08 33.5 0.1 2.5 1 1 1 2 2 2 2 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 CDW60439.1 - 3.3e-08 34.1 0.0 9.3e-08 32.6 0.0 1.8 2 1 0 2 2 2 1 Radical SAM superfamily LSM PF01423.22 CDW60440.1 - 2.3e-19 68.8 0.0 2.6e-19 68.7 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDW60440.1 - 5.8e-06 26.4 0.0 6.8e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CDW60440.1 - 0.047 13.8 0.1 0.051 13.7 0.1 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain EGF PF00008.27 CDW60441.1 - 9.1e-34 115.4 143.1 5.2e-08 33.1 9.8 10.2 9 1 0 9 9 9 9 EGF-like domain EGF_CA PF07645.15 CDW60441.1 - 3.5e-23 81.5 165.4 9.6e-09 35.3 13.2 10.1 4 2 5 9 9 9 7 Calcium-binding EGF domain hEGF PF12661.7 CDW60441.1 - 3.4e-18 65.5 119.4 0.0003 21.3 6.8 11.1 9 2 1 10 10 10 8 Human growth factor-like EGF EGF_2 PF07974.13 CDW60441.1 - 4.1e-13 49.4 166.2 0.0005 20.4 10.4 10.4 9 1 1 10 10 10 7 EGF-like domain FXa_inhibition PF14670.6 CDW60441.1 - 7.5e-09 35.7 138.7 0.018 15.3 8.7 10.4 4 2 6 10 10 10 6 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 CDW60441.1 - 1.7e-07 31.3 156.6 0.00034 20.7 14.6 10.9 8 2 1 9 9 9 7 EGF domain Exo_endo_phos PF03372.23 CDW60442.1 - 2.3e-12 46.9 0.0 4.7e-12 45.9 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Piwi PF02171.17 CDW60443.1 - 4.2e-50 170.7 0.0 8.1e-50 169.8 0.0 1.4 1 0 0 1 1 1 1 Piwi domain ArgoL1 PF08699.10 CDW60443.1 - 7.6e-10 38.3 0.2 2.5e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 Argonaute linker 1 domain PAZ PF02170.22 CDW60443.1 - 7.7e-10 38.7 0.0 1.1e-06 28.5 0.0 2.4 1 1 1 2 2 2 2 PAZ domain ArgoL2 PF16488.5 CDW60443.1 - 3.3e-09 36.9 0.0 9.4e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoN PF16486.5 CDW60443.1 - 9.7e-08 32.7 0.0 1.8e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoMid PF16487.5 CDW60443.1 - 8.9e-07 29.1 0.0 4.8e-06 26.7 0.0 2.2 2 0 0 2 2 2 1 Mid domain of argonaute SRPRB PF09439.10 CDW60443.1 - 0.19 11.2 0.0 0.42 10.0 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit UAA PF08449.11 CDW60444.1 - 1.7e-62 211.3 21.5 2.1e-62 211.0 21.5 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 CDW60444.1 - 1e-12 48.4 27.6 5.1e-09 36.4 11.3 2.5 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 CDW60444.1 - 1.6e-09 37.6 15.3 6.7e-09 35.5 15.3 1.8 1 1 0 1 1 1 1 Triose-phosphate Transporter family SLC35F PF06027.12 CDW60444.1 - 0.0011 18.6 14.2 0.0013 18.4 14.2 1.2 1 0 0 1 1 1 1 Solute carrier family 35 AdoMet_MTase PF07757.13 CDW60444.1 - 0.059 13.7 0.3 0.12 12.7 0.0 1.6 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase LMBR1 PF04791.16 CDW60445.1 - 8.2e-41 140.5 31.2 7.4e-23 81.2 8.8 3.0 2 1 1 3 3 3 3 LMBR1-like membrane protein NdhL PF10716.9 CDW60445.1 - 0.42 10.6 0.0 0.42 10.6 0.0 3.2 3 0 0 3 3 3 0 NADH dehydrogenase transmembrane subunit zf-CpG_bind_C PF12269.8 CDW60446.1 - 4e-14 53.0 2.4 5.8e-14 52.5 2.4 1.2 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain Trehalase PF01204.18 CDW60447.1 - 2.5e-59 201.5 10.2 3.8e-31 108.5 1.3 4.3 1 1 2 3 3 3 3 Trehalase GTP_EFTU PF00009.27 CDW60449.1 - 1.8e-56 190.8 0.0 2.8e-56 190.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CDW60449.1 - 7.6e-27 93.2 0.0 1.5e-26 92.2 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 CDW60449.1 - 9.4e-19 67.2 0.0 2.1e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CDW60449.1 - 5.1e-07 30.0 0.0 1.3e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 CDW60449.1 - 1.7e-06 27.8 0.0 3.6e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV RF3_C PF16658.5 CDW60449.1 - 5.5e-06 26.2 0.0 9.8e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 CDW60449.1 - 0.003 17.6 0.1 0.008 16.3 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CDW60449.1 - 0.066 12.7 0.3 1.3 8.6 0.1 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B MutS_I PF01624.20 CDW60451.1 - 1.1e-43 148.0 0.0 2e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 CDW60451.1 - 4.7e-34 118.3 0.9 7.5e-34 117.6 0.9 1.4 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 CDW60451.1 - 1.5e-33 116.0 0.0 2.8e-33 115.1 0.0 1.5 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CDW60451.1 - 1.8e-29 101.9 0.1 4.8e-29 100.6 0.1 1.8 1 0 0 1 1 1 1 MutS family domain IV YgbA_NO PF11756.8 CDW60452.1 - 3.1e-39 133.6 3.0 3.7e-39 133.4 3.0 1.0 1 0 0 1 1 1 1 Nitrous oxide-stimulated promoter AFOR_C PF01314.18 CDW60452.1 - 0.097 11.7 0.3 0.097 11.7 0.3 1.1 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 Sigma54_activat PF00158.26 CDW60453.1 - 1.6e-70 236.2 0.1 2.8e-70 235.4 0.1 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 CDW60453.1 - 4e-22 78.8 0.0 1e-21 77.5 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain GAF PF01590.26 CDW60453.1 - 4.2e-18 66.2 0.1 2.2e-12 47.7 0.0 2.5 2 0 0 2 2 2 2 GAF domain GAF_2 PF13185.6 CDW60453.1 - 4.8e-11 43.1 0.0 8.2e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 CDW60453.1 - 5.3e-11 43.0 0.1 5.5e-10 39.7 0.0 2.4 2 0 0 2 2 2 1 GAF domain AAA_5 PF07728.14 CDW60453.1 - 1.4e-07 31.6 0.1 3.3e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 CDW60453.1 - 3.9e-06 27.3 0.0 1e-05 25.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) HTH_8 PF02954.19 CDW60453.1 - 0.00011 22.0 0.2 0.00011 22.0 0.2 2.3 3 0 0 3 3 3 1 Bacterial regulatory protein, Fis family Mg_chelatase PF01078.21 CDW60453.1 - 0.0012 18.2 0.4 0.55 9.6 0.0 2.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CDW60453.1 - 0.0085 15.8 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CDW60453.1 - 0.0095 16.3 0.3 0.038 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 CDW60453.1 - 0.029 14.9 0.1 0.4 11.2 0.0 2.7 3 0 0 3 3 3 0 ABC transporter AAA_7 PF12775.7 CDW60453.1 - 0.043 13.3 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 CDW60453.1 - 0.062 13.0 0.0 0.31 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain HTH_50 PF18024.1 CDW60453.1 - 0.072 12.7 0.1 0.24 11.0 0.1 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain AAA_3 PF07726.11 CDW60453.1 - 0.13 12.1 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AIRS_C PF02769.22 CDW60454.1 - 5.7e-26 91.5 2.7 8.8e-26 90.9 2.7 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 CDW60454.1 - 7.4e-16 58.6 0.6 2e-15 57.2 0.6 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain HypD PF01924.16 CDW60455.1 - 4.3e-148 493.1 0.0 4.8e-148 492.9 0.0 1.0 1 0 0 1 1 1 1 Hydrogenase formation hypA family cobW PF02492.19 CDW60456.1 - 7.9e-33 113.5 0.0 1.2e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain HupF_HypC PF01455.18 CDW60456.1 - 8.7e-25 86.7 1.4 1.1e-24 86.3 0.2 1.8 2 0 0 2 2 2 1 HupF/HypC family Zeta_toxin PF06414.12 CDW60456.1 - 0.043 13.1 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 CDW60456.1 - 0.083 13.2 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 CDW60456.1 - 0.1 12.5 0.1 0.38 10.6 0.1 2.1 2 1 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 CDW60456.1 - 0.15 12.4 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Viral_helicase1 PF01443.18 CDW60456.1 - 0.21 11.3 0.0 0.34 10.6 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase HycA_repressor PF11046.8 CDW60457.1 - 1.2e-75 252.6 0.9 1.3e-75 252.5 0.9 1.0 1 0 0 1 1 1 1 Transcriptional repressor of hyc and hyp operons RNA_pol_Rpb2_45 PF10385.9 CDW60457.1 - 0.12 12.6 0.0 0.49 10.7 0.0 1.8 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Fer4_11 PF13247.6 CDW60458.1 - 8.5e-10 38.7 10.9 4.5e-07 29.9 4.3 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 CDW60458.1 - 1.1e-08 35.8 8.8 0.011 16.7 0.4 3.4 3 0 0 3 3 3 3 4Fe-4S double cluster binding domain Fer4 PF00037.27 CDW60458.1 - 8e-08 31.8 25.2 2e-06 27.4 1.3 4.4 5 0 0 5 5 5 3 4Fe-4S binding domain Fer4_7 PF12838.7 CDW60458.1 - 1.2e-06 29.0 17.8 0.0014 19.2 8.8 3.0 1 1 3 4 4 4 4 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDW60458.1 - 7.5e-06 25.8 23.9 0.0034 17.4 1.1 3.7 3 1 0 3 3 3 2 4Fe-4S binding domain Fer4_9 PF13187.6 CDW60458.1 - 1.4e-05 25.2 13.6 0.015 15.5 10.3 3.0 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDW60458.1 - 0.00036 20.6 15.9 0.048 13.8 0.9 3.2 2 1 1 3 3 3 3 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDW60458.1 - 0.00057 20.6 30.6 0.074 14.0 2.6 3.6 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_21 PF14697.6 CDW60458.1 - 0.012 15.7 12.0 0.012 15.7 12.0 3.1 2 2 0 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 CDW60458.1 - 0.013 15.7 1.3 0.038 14.1 0.5 2.0 2 0 0 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_2 PF12797.7 CDW60458.1 - 0.09 12.9 1.0 0.09 12.9 1.0 3.5 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_17 PF13534.6 CDW60458.1 - 1.6 9.3 17.0 1.9 9.1 2.4 3.4 2 1 2 4 4 4 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDW60458.1 - 2.6 8.6 16.7 2.3 8.8 0.9 3.2 2 1 1 3 3 3 0 4Fe-4S dicluster domain TruB_N PF01509.18 CDW60459.1 - 0.13 12.7 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) BPD_transp_1 PF00528.22 CDW60461.1 - 0.00063 19.5 0.8 0.00063 19.5 0.8 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF2937 PF11157.8 CDW60461.1 - 0.015 15.0 1.0 0.065 13.0 1.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2937) Integrase_Zn PF02022.19 CDW60461.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Integrase Zinc binding domain SBP_bac_5 PF00496.22 CDW60462.1 - 6.8e-99 331.4 10.7 8.7e-99 331.0 10.7 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Ssl1 PF04056.14 CDW60462.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.6 2 0 0 2 2 2 0 Ssl1-like Asparaginase_2 PF01112.18 CDW60463.1 - 5.4e-118 393.5 3.0 7.6e-118 393.0 3.0 1.2 1 0 0 1 1 1 1 Asparaginase ABC_tran PF00005.27 CDW60463.1 - 1.1e-60 204.1 0.0 3.1e-29 102.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter oligo_HPY PF08352.12 CDW60463.1 - 1.1e-18 67.5 0.1 7.5e-08 32.8 0.0 2.5 2 0 0 2 2 2 2 Oligopeptide/dipeptide transporter, C-terminal region AAA_22 PF13401.6 CDW60463.1 - 3.4e-12 46.8 0.6 6.9e-05 23.1 0.0 3.7 2 2 0 2 2 2 2 AAA domain SMC_N PF02463.19 CDW60463.1 - 4.6e-11 42.6 0.2 1.1e-06 28.3 0.2 2.8 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CDW60463.1 - 4.3e-10 40.2 0.7 0.0006 20.2 0.1 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 CDW60463.1 - 9.6e-08 32.2 0.5 0.0024 17.8 0.0 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CDW60463.1 - 1.3e-06 28.0 0.2 0.056 13.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CDW60463.1 - 1.7e-06 27.5 0.0 0.0022 17.3 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.17 CDW60463.1 - 8.4e-06 25.6 0.3 0.00091 19.0 0.0 2.9 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_30 PF13604.6 CDW60463.1 - 3.5e-05 23.6 0.2 0.27 10.9 0.0 2.7 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 CDW60463.1 - 0.00051 20.0 0.3 1.4 8.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase DUF87 PF01935.17 CDW60463.1 - 0.0012 19.0 2.1 0.73 9.9 0.4 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_5 PF07728.14 CDW60463.1 - 0.0014 18.7 0.3 1.5 8.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) APS_kinase PF01583.20 CDW60463.1 - 0.0029 17.5 0.2 1.6 8.6 0.0 2.4 2 0 0 2 2 2 1 Adenylylsulphate kinase FtsK_SpoIIIE PF01580.18 CDW60463.1 - 0.003 16.9 0.9 1.8 7.8 0.0 2.9 3 0 0 3 3 2 2 FtsK/SpoIIIE family TniB PF05621.11 CDW60463.1 - 0.0041 16.6 1.3 1.4 8.3 0.2 3.7 4 0 0 4 4 4 1 Bacterial TniB protein AAA_7 PF12775.7 CDW60463.1 - 0.0051 16.3 0.2 0.98 8.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 CDW60463.1 - 0.0053 16.4 0.1 1.5 8.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain TrwB_AAD_bind PF10412.9 CDW60463.1 - 0.0056 15.6 0.7 1.9 7.3 0.1 2.5 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain Sigma54_activat PF00158.26 CDW60463.1 - 0.0076 16.0 0.1 1.8 8.3 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF3987 PF13148.6 CDW60463.1 - 0.0077 15.3 0.2 1.1 8.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) CbiA PF01656.23 CDW60463.1 - 0.0086 16.1 2.3 0.17 11.9 0.3 2.6 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.12 CDW60463.1 - 0.01 15.8 0.4 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 CDW60463.1 - 0.012 14.7 0.8 6.7 5.7 0.0 3.4 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_33 PF13671.6 CDW60463.1 - 0.015 15.5 0.0 8 6.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CDW60463.1 - 0.016 15.6 0.0 6.3 7.2 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Hpr_kinase_C PF07475.12 CDW60463.1 - 0.017 14.6 1.0 0.13 11.8 0.1 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain ResIII PF04851.15 CDW60463.1 - 0.035 14.1 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 CDW60463.1 - 0.037 13.4 0.1 5.4 6.3 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CDW60463.1 - 0.043 14.4 0.1 6.1 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 CDW60463.1 - 0.047 13.4 0.4 4.6 6.9 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.25 CDW60463.1 - 0.049 13.3 0.0 1.3 8.6 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AIG1 PF04548.16 CDW60463.1 - 0.059 12.7 0.7 1.6 8.0 0.1 2.3 2 0 0 2 2 2 0 AIG1 family AAA_24 PF13479.6 CDW60463.1 - 0.12 12.1 0.1 10 5.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 CDW60463.1 - 0.12 11.8 1.1 3.7 6.9 0.1 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein G-alpha PF00503.20 CDW60463.1 - 0.19 10.9 0.0 6.4 5.8 0.0 2.1 2 0 0 2 2 2 0 G-protein alpha subunit MoeA_N PF03453.17 CDW60464.1 - 1.9e-48 164.2 0.1 2.5e-48 163.8 0.1 1.2 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoCF_biosynth PF00994.24 CDW60464.1 - 1.3e-27 96.2 0.0 1.9e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 Probable molybdopterin binding domain MoeA_C PF03454.15 CDW60464.1 - 2.6e-22 78.8 0.1 7.9e-22 77.2 0.0 1.9 2 0 0 2 2 2 1 MoeA C-terminal region (domain IV) ThiF PF00899.21 CDW60465.1 - 4.1e-64 216.3 0.3 5e-64 216.0 0.3 1.0 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 CDW60465.1 - 0.00045 20.5 1.4 0.0036 17.5 1.4 2.0 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CDW60465.1 - 0.0071 16.8 0.1 0.014 15.8 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CDW60465.1 - 0.064 13.3 0.1 0.23 11.5 0.0 1.8 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 CDW60465.1 - 0.11 11.8 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain TAL_FSA PF00923.19 CDW60466.1 - 1.4e-44 152.6 0.1 3.2e-44 151.4 0.1 1.6 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase PFL-like PF02901.15 CDW60467.1 - 9.2e-96 321.9 0.1 1.2e-95 321.5 0.1 1.1 1 0 0 1 1 1 1 Pyruvate formate lyase-like Radical_SAM PF04055.21 CDW60467.1 - 2.3e-32 112.7 0.0 5e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CDW60467.1 - 1.4e-10 41.6 0.4 3.4e-09 37.1 0.2 2.7 2 1 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CDW60467.1 - 0.0007 19.7 1.6 0.21 11.7 1.6 2.6 1 1 0 1 1 1 1 4Fe-4S single cluster domain G3P_antiterm PF04309.12 CDW60467.1 - 0.027 13.9 0.0 0.054 12.9 0.0 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator Fer4_13 PF13370.6 CDW60467.1 - 0.078 13.5 0.2 0.23 12.0 0.2 1.9 1 0 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 CDW60467.1 - 0.31 11.8 1.6 2.4 8.9 1.6 2.5 1 1 0 1 1 1 0 4Fe-4S single cluster domain Mastoparan PF08249.11 CDW60467.1 - 8.2 7.5 8.0 7 7.7 4.9 2.7 2 0 0 2 2 2 0 Mastoparan protein Peptidase_A17 PF05380.13 CDW60469.1 - 1.7e-13 50.9 0.6 3.8e-13 49.8 0.1 2.0 2 0 0 2 2 2 1 Pao retrotransposon peptidase DUF1759 PF03564.15 CDW60469.1 - 3.7e-13 49.7 4.0 1.2e-12 47.9 0.1 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 CDW60469.1 - 2.1e-11 43.8 0.0 6.7e-11 42.2 0.0 1.8 2 0 0 2 2 2 1 Putative peptidase (DUF1758) RVT_1 PF00078.27 CDW60469.1 - 6.4e-07 29.1 0.0 1.3e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 CDW60469.1 - 0.16 12.6 0.0 0.39 11.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease DDE_Tnp_IS1 PF03400.13 CDW60470.1 - 9.6e-73 242.7 1.6 1.1e-72 242.5 1.6 1.0 1 0 0 1 1 1 1 IS1 transposase DDE_Tnp_IS240 PF13610.6 CDW60470.1 - 0.039 14.2 0.6 0.12 12.6 0.6 1.7 1 1 0 1 1 1 0 DDE domain PGM_PMM_I PF02878.16 CDW60471.1 - 3e-36 124.2 0.2 1e-35 122.5 0.1 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDW60471.1 - 3.9e-31 107.6 0.0 7.9e-31 106.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDW60471.1 - 8.1e-20 71.4 0.0 2.2e-19 70.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDW60471.1 - 1.4e-08 34.8 0.0 4.1e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain SeqA PF03925.13 CDW60472.1 - 2.5e-49 165.8 0.0 3.5e-49 165.4 0.0 1.2 1 0 0 1 1 1 1 SeqA protein C-terminal domain SeqA_N PF17206.3 CDW60472.1 - 4.5e-24 83.5 0.4 7.6e-24 82.7 0.4 1.4 1 0 0 1 1 1 1 SeqA protein N-terminal domain VAPB_antitox PF02697.14 CDW60472.1 - 0.01 16.6 0.3 0.039 14.7 0.2 2.1 1 1 0 1 1 1 0 Putative antitoxin Abhydrolase_1 PF00561.20 CDW60473.1 - 4.1e-24 85.6 0.6 2.6e-18 66.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CDW60473.1 - 7e-19 69.3 6.1 8.1e-19 69.1 6.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CDW60473.1 - 4e-11 42.6 0.1 5.4e-08 32.4 0.1 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 PGAP1 PF07819.13 CDW60473.1 - 3.1e-09 36.9 0.2 4.9e-05 23.2 0.0 2.3 2 1 0 3 3 3 2 PGAP1-like protein Thioesterase PF00975.20 CDW60473.1 - 0.00014 22.0 0.0 0.00019 21.6 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain DUF915 PF06028.11 CDW60473.1 - 0.00072 19.0 0.0 0.092 12.1 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 CDW60473.1 - 0.0015 18.1 0.0 0.0029 17.1 0.0 1.5 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_4 PF08386.10 CDW60473.1 - 0.015 15.4 0.0 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 TAP-like protein Ndr PF03096.14 CDW60473.1 - 0.017 13.8 0.0 2.8 6.6 0.0 2.1 2 0 0 2 2 2 0 Ndr family Chlorophyllase2 PF12740.7 CDW60473.1 - 0.11 11.4 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Flavodoxin_1 PF00258.25 CDW60474.1 - 1.2e-33 116.3 0.1 1.8e-33 115.8 0.1 1.2 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_3 PF12641.7 CDW60474.1 - 2.9e-10 40.1 0.0 4.7e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain RHH_1 PF01402.21 CDW60474.1 - 3.3e-07 30.0 1.8 6.9e-07 29.0 1.8 1.6 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family Flavodoxin_5 PF12724.7 CDW60474.1 - 5.4e-07 29.9 0.0 9.8e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin domain RHH_4 PF13467.6 CDW60474.1 - 0.036 14.0 0.1 0.079 12.9 0.1 1.6 1 0 0 1 1 1 0 Ribbon-helix-helix domain Flavodoxin_4 PF12682.7 CDW60474.1 - 0.089 12.5 0.0 0.26 11.0 0.0 1.7 1 1 0 1 1 1 0 Flavodoxin Njmu-R1 PF15053.6 CDW60474.1 - 0.098 11.7 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Mjmu-R1-like protein family FUR PF01475.19 CDW60475.1 - 6.4e-49 165.1 0.2 7.6e-49 164.9 0.2 1.1 1 0 0 1 1 1 1 Ferric uptake regulator family HTH_12 PF08461.10 CDW60475.1 - 0.0013 18.7 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain PadR PF03551.14 CDW60475.1 - 0.0033 17.4 0.0 0.006 16.5 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family SR1P PF13790.6 CDW60475.1 - 0.0063 16.6 3.8 0.18 12.0 0.3 2.4 2 0 0 2 2 2 2 SR1 protein HTH_28 PF13518.6 CDW60475.1 - 0.12 12.5 0.0 23 5.2 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Tnp_Tc3_2 PF01498.18 CDW60475.1 - 0.15 12.3 0.0 3.7 7.9 0.0 2.3 1 1 1 2 2 2 0 Transposase OprD PF03573.13 CDW60476.1 - 1.9e-25 89.8 12.6 2.4e-25 89.4 12.6 1.1 1 0 0 1 1 1 1 outer membrane porin, OprD family OMP_b-brl_2 PF13568.6 CDW60476.1 - 2.8 7.9 14.4 4.8 7.2 7.1 3.9 2 2 1 3 3 3 0 Outer membrane protein beta-barrel domain tRNA-synt_1c PF00749.21 CDW60477.1 - 1.8e-128 427.8 0.0 2.3e-128 427.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CDW60477.1 - 1.3e-63 214.0 0.0 2.6e-63 213.0 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain DUF588 PF04535.12 CDW60481.1 - 0.15 11.9 0.1 1 9.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF588) DUF4668 PF15701.5 CDW60481.1 - 0.36 10.7 2.7 0.66 9.8 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) STb_secrete PF09075.10 CDW60481.1 - 0.46 10.6 14.8 0.62 10.2 0.0 3.8 3 1 1 4 4 4 0 Heat-stable enterotoxin B, secretory RabGAP-TBC PF00566.18 CDW60482.1 - 8.8e-16 58.2 3.7 8.8e-16 58.2 3.7 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 CDW60482.1 - 1.5e-05 25.4 0.0 2.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Motile_Sperm PF00635.26 CDW60483.1 - 7.3e-07 29.0 0.0 1.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain YbjQ_1 PF01906.17 CDW60485.1 - 1.3e-35 122.1 0.3 1.9e-35 121.6 0.3 1.2 1 0 0 1 1 1 1 Putative heavy-metal-binding Amidase_2 PF01510.25 CDW60485.1 - 1.3e-25 90.3 0.0 2e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 N-acetylmuramoyl-L-alanine amidase SBP_bac_3 PF00497.20 CDW60486.1 - 3.9e-66 222.7 0.9 5.8e-66 222.2 0.9 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ABC_tran PF00005.27 CDW60486.1 - 2.2e-34 118.9 0.0 4.8e-34 117.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter DUF3828 PF12883.7 CDW60486.1 - 5.4e-27 94.6 0.0 1.1e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3828) AAA_21 PF13304.6 CDW60486.1 - 1.9e-11 44.3 0.7 1.7e-06 28.1 0.1 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW60486.1 - 9.5e-06 25.2 0.0 0.00047 19.7 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CDW60486.1 - 0.00022 21.1 1.0 0.12 12.1 0.4 2.5 3 0 0 3 3 3 2 AAA ATPase domain Lig_chan-Glu_bd PF10613.9 CDW60486.1 - 0.00027 21.1 0.0 0.0068 16.6 0.0 2.5 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site RsgA_GTPase PF03193.16 CDW60486.1 - 0.00056 19.9 0.0 0.0014 18.5 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_5 PF07728.14 CDW60486.1 - 0.0015 18.5 1.5 2.4 8.2 0.0 3.4 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW60486.1 - 0.0016 18.9 0.0 0.0039 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 CDW60486.1 - 0.0036 17.0 0.0 0.0089 15.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 CDW60486.1 - 0.01 14.5 0.0 0.042 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CDW60486.1 - 0.015 15.8 0.0 0.034 14.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDW60486.1 - 0.033 14.5 0.1 0.37 11.1 0.1 2.6 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CDW60486.1 - 0.078 12.7 0.4 3.5 7.3 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein BPD_transp_1 PF00528.22 CDW60487.1 - 2.2e-15 56.9 12.7 2.9e-15 56.5 12.7 1.2 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component SBP_bac_3 PF00497.20 CDW60488.1 - 2.2e-70 236.6 0.3 2.8e-70 236.3 0.3 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 BPD_transp_1 PF00528.22 CDW60488.1 - 2.8e-09 37.0 10.8 3.8e-09 36.5 9.3 1.8 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Lig_chan-Glu_bd PF10613.9 CDW60488.1 - 6.1e-06 26.4 0.0 0.00014 22.0 0.0 2.3 1 1 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site NMT1 PF09084.11 CDW60488.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.5 1 0 0 1 1 1 1 NMT1/THI5 like NMT1_3 PF16868.5 CDW60488.1 - 0.025 14.0 0.0 0.048 13.1 0.0 1.4 1 0 0 1 1 1 0 NMT1-like family Phosphonate-bd PF12974.7 CDW60488.1 - 0.042 13.4 0.1 0.12 11.9 0.1 1.7 1 1 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein tRNA_U5-meth_tr PF05958.11 CDW60489.1 - 0.00091 18.3 0.0 0.0068 15.4 0.0 1.9 2 0 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 CDW60489.1 - 0.16 11.8 0.1 0.28 10.9 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF2593 PF10767.9 CDW60490.1 - 8e-63 210.7 7.1 9.2e-63 210.5 7.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2593) BPD_transp_1 PF00528.22 CDW60491.1 - 1.8e-14 53.9 13.9 2.1e-14 53.7 13.9 1.1 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component Kunitz_BPTI PF00014.23 CDW60492.1 - 3e-41 139.4 28.1 1e-19 70.5 9.2 3.8 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain SH2 PF00017.24 CDW60492.1 - 1.6e-11 44.1 0.4 0.11 12.6 0.3 4.4 4 0 0 4 4 4 4 SH2 domain Inhibitor_I68 PF10468.9 CDW60492.1 - 9.9 6.6 11.9 21 5.6 1.7 2.5 2 0 0 2 2 2 0 Carboxypeptidase inhibitor I68 Pkinase PF00069.25 CDW60493.1 - 3.1e-72 243.1 0.0 3.6e-72 242.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60493.1 - 7.6e-37 127.0 0.0 9.5e-37 126.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW60493.1 - 0.00023 20.6 0.0 0.00064 19.1 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CDW60493.1 - 0.00032 19.8 0.0 0.0026 16.8 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain CDC4_D PF16856.5 CDW60493.1 - 0.019 14.8 0.1 0.047 13.6 0.1 1.7 1 0 0 1 1 1 0 Cell division control protein 4 dimerisation domain Kdo PF06293.14 CDW60493.1 - 0.067 12.5 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CDW60493.1 - 0.1 12.2 0.2 2.7 7.5 0.0 2.1 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Paf1 PF03985.13 CDW60494.1 - 3.6e-49 167.9 0.5 4.3e-49 167.7 0.5 1.0 1 0 0 1 1 1 1 Paf1 N_NLPC_P60 PF12912.7 CDW60494.1 - 0.13 12.6 0.2 0.32 11.3 0.2 1.6 1 0 0 1 1 1 0 NLPC_P60 stabilising domain, N term Pkinase PF00069.25 CDW60495.1 - 3.6e-56 190.4 0.2 4e-56 190.3 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60495.1 - 1.3e-33 116.4 0.0 1.5e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CDW60495.1 - 0.00011 21.8 0.1 0.00015 21.5 0.1 1.1 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 CDW60495.1 - 0.00026 20.4 0.0 0.00035 20.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CDW60495.1 - 0.0022 18.0 0.3 0.0075 16.2 0.3 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW60495.1 - 0.011 15.1 0.5 0.016 14.5 0.5 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CDW60495.1 - 0.013 14.4 0.3 0.015 14.3 0.3 1.1 1 0 0 1 1 1 0 Haspin like kinase domain YukC PF10140.9 CDW60495.1 - 0.078 11.8 0.0 0.12 11.2 0.0 1.3 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC HTH_Tnp_Tc5 PF03221.16 CDW60497.1 - 1.7e-13 50.4 1.7 2e-13 50.2 0.3 1.8 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain BrkDBD PF09607.10 CDW60497.1 - 1.6e-12 47.0 0.6 3.5e-12 45.9 0.6 1.5 1 0 0 1 1 1 1 Brinker DNA-binding domain HTH_Tnp_1 PF01527.20 CDW60497.1 - 0.00017 21.8 3.3 0.00017 21.8 3.3 2.1 1 1 0 2 2 2 1 Transposase HTH_28 PF13518.6 CDW60497.1 - 0.051 13.7 1.0 0.14 12.3 1.0 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain POR_N PF01855.19 CDW60499.1 - 3.1e-81 272.5 1.1 4.9e-81 271.9 1.1 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 CDW60499.1 - 1.2e-34 119.9 0.0 2.2e-34 119.1 0.0 1.4 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase EKR PF10371.9 CDW60499.1 - 3.4e-23 81.2 0.0 7e-23 80.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function PFOR_II PF17147.4 CDW60499.1 - 2.5e-16 59.8 0.0 9e-16 58.1 0.0 1.9 2 0 0 2 2 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Fer4_16 PF13484.6 CDW60499.1 - 3.9e-10 40.5 7.8 1.1e-09 39.0 7.8 1.9 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_7 PF12838.7 CDW60499.1 - 1.7e-09 38.1 8.8 1.7e-09 38.1 8.8 2.0 2 0 0 2 2 1 1 4Fe-4S dicluster domain Fer4 PF00037.27 CDW60499.1 - 7.5e-09 35.0 20.6 2.5e-05 23.9 1.3 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain TPP_enzyme_C PF02775.21 CDW60499.1 - 8.5e-09 35.4 0.1 2.7e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Fer4_9 PF13187.6 CDW60499.1 - 3.4e-08 33.5 20.5 3.3e-07 30.4 10.1 2.6 2 1 2 4 4 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.7 CDW60499.1 - 4.2e-08 32.9 19.1 5.2e-06 26.3 2.3 3.2 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_21 PF14697.6 CDW60499.1 - 1e-07 31.9 11.5 1e-07 31.9 11.5 2.6 2 1 0 2 2 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CDW60499.1 - 3.1e-07 30.4 12.5 3.7e-06 27.0 12.4 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDW60499.1 - 4.5e-06 27.1 8.6 1.3e-05 25.7 7.7 2.3 2 1 0 2 2 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDW60499.1 - 7.3e-06 25.8 17.6 0.005 16.9 3.6 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_18 PF13746.6 CDW60499.1 - 0.0004 20.6 4.0 0.051 13.8 0.2 2.5 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CDW60499.1 - 0.0005 20.5 12.9 0.00067 20.1 11.5 2.0 2 1 0 2 2 1 1 4Fe-4S dicluster domain Transketolase_C PF02780.20 CDW60499.1 - 0.0019 18.1 0.3 0.011 15.7 0.0 2.4 3 0 0 3 3 3 1 Transketolase, C-terminal domain Fer4_15 PF13459.6 CDW60499.1 - 0.013 16.3 2.9 1.7 9.5 0.3 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_3 PF12798.7 CDW60499.1 - 0.025 15.5 4.8 0.025 15.5 4.8 3.0 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_13 PF13370.6 CDW60499.1 - 0.042 14.4 10.7 0.22 12.1 0.7 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I FlgM PF04316.13 CDW60499.1 - 0.081 13.3 0.1 0.33 11.4 0.1 2.1 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM Fer4_4 PF12800.7 CDW60499.1 - 0.15 12.6 18.1 0.32 11.6 1.5 3.0 3 0 0 3 3 3 0 4Fe-4S binding domain HEAT_2 PF13646.6 CDW60499.1 - 0.37 11.2 3.4 0.41 11.1 1.6 2.0 2 0 0 2 2 1 0 HEAT repeats Fer4_22 PF17179.4 CDW60499.1 - 3.2 8.6 8.4 4 8.4 0.2 2.8 3 0 0 3 3 2 0 4Fe-4S dicluster domain META PF03724.16 CDW60500.1 - 1.3e-22 79.8 0.1 1.6e-22 79.6 0.1 1.1 1 0 0 1 1 1 1 META domain 2-Hacid_dh_C PF02826.19 CDW60501.1 - 2.6e-53 180.0 0.0 4e-53 179.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CDW60501.1 - 4.3e-35 120.3 0.0 5e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CDW60501.1 - 5.2e-05 23.5 0.0 0.00018 21.7 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 CDW60501.1 - 0.0037 17.4 0.0 0.0077 16.3 0.0 1.5 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 CDW60501.1 - 0.0038 17.7 0.0 0.024 15.1 0.0 2.2 3 0 0 3 3 3 1 XdhC Rossmann domain CoA_binding_2 PF13380.6 CDW60501.1 - 0.11 13.0 0.0 0.29 11.6 0.0 1.8 1 0 0 1 1 1 0 CoA binding domain DctA-YdbH PF11739.8 CDW60502.1 - 1.9e-62 210.7 1.1 4.7e-62 209.4 0.2 2.2 2 0 0 2 2 2 1 Dicarboxylate transport DUF748 PF05359.11 CDW60502.1 - 0.029 14.5 0.0 1.2 9.3 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function (DUF748) HLH PF00010.26 CDW60503.1 - 1.6e-12 47.2 0.6 3.7e-12 46.0 0.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tim44 PF04280.15 CDW60504.1 - 2.4e-22 79.6 0.0 8.2e-21 74.7 0.0 2.9 2 2 0 2 2 2 1 Tim44-like domain MIF4G PF02854.19 CDW60504.1 - 0.0016 18.1 4.2 0.0032 17.1 3.9 1.6 1 1 0 1 1 1 1 MIF4G domain Pox_D5 PF03288.16 CDW60504.1 - 0.13 12.7 0.4 17 6.0 0.0 3.3 3 0 0 3 3 3 0 Poxvirus D5 protein-like RecG_N PF17190.4 CDW60504.1 - 1 10.1 5.6 1 10.1 2.1 2.5 2 0 0 2 2 2 0 RecG N-terminal helical domain F-box PF00646.33 CDW60505.1 - 0.00096 19.0 0.1 0.0023 17.8 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CDW60505.1 - 0.0031 17.4 0.2 0.007 16.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like TPR_2 PF07719.17 CDW60506.1 - 2.7e-23 80.2 14.5 5.4e-06 26.1 0.0 10.4 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_1 PF00515.28 CDW60506.1 - 5.2e-21 73.5 17.3 1.4e-07 31.0 0.1 9.0 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 CDW60506.1 - 2.6e-13 50.1 13.5 1.7e-05 25.0 0.1 6.6 8 1 0 8 8 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 CDW60506.1 - 8.7e-13 47.4 7.1 0.0037 17.4 0.0 7.5 8 0 0 8 8 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW60506.1 - 7.7e-12 45.3 15.4 5.9e-10 39.2 0.2 5.3 4 2 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 CDW60506.1 - 2.2e-10 39.8 7.9 0.001 18.9 0.0 6.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 CDW60506.1 - 1.7e-07 31.4 19.8 1.4 9.9 0.0 8.8 7 2 2 9 9 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 CDW60506.1 - 2.6e-07 30.5 4.9 0.17 12.3 0.0 7.5 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW60506.1 - 3.9e-07 29.6 0.9 0.08 12.6 0.0 5.1 5 0 0 5 5 5 2 TPR repeat TPR_19 PF14559.6 CDW60506.1 - 2.5e-06 27.9 10.7 2.5 8.7 0.1 6.9 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_10 PF13374.6 CDW60506.1 - 7.8e-05 22.4 9.6 0.74 9.8 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 CDW60506.1 - 0.00016 22.2 8.5 7.1 7.4 0.0 6.4 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW60506.1 - 0.00019 21.8 9.6 0.5 11.1 0.0 5.4 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW60506.1 - 0.00056 20.0 9.4 0.65 10.2 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat Ly-6_related PF06579.12 CDW60507.1 - 2e-06 28.0 8.9 1.4e-05 25.4 1.3 2.3 2 0 0 2 2 2 2 Caenorhabditis elegans ly-6-related protein Metallophos PF00149.28 CDW60508.1 - 2.5e-22 80.4 0.0 3.9e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW60508.1 - 3.2e-05 24.3 0.0 6.3e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PPP5 PF08321.12 CDW60508.1 - 0.047 14.0 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 PPP5 TPR repeat region SAPS PF04499.15 CDW60510.1 - 0.034 12.9 0.2 0.038 12.8 0.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ras PF00071.22 CDW60511.1 - 7.7e-54 181.7 0.0 9.4e-54 181.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CDW60511.1 - 5.6e-36 123.4 0.0 7.5e-36 123.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CDW60511.1 - 2.3e-13 50.0 0.0 2.6e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CDW60511.1 - 2.5e-07 30.3 0.0 3.8e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CDW60511.1 - 9e-06 25.8 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CDW60511.1 - 1.5e-05 24.5 0.0 2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 CDW60511.1 - 2.3e-05 24.1 0.0 0.0001 21.9 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 CDW60511.1 - 0.0099 16.3 0.0 0.07 13.5 0.0 2.3 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CDW60511.1 - 0.014 15.3 0.1 0.029 14.3 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 CDW60511.1 - 0.014 15.7 0.1 0.025 15.0 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CDW60511.1 - 0.018 14.6 0.1 0.03 13.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 CDW60511.1 - 0.031 14.1 0.4 5.2 6.8 0.0 2.2 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 CDW60511.1 - 0.035 14.0 0.1 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase DLIC PF05783.11 CDW60511.1 - 0.043 12.7 0.0 0.052 12.4 0.0 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) TsaE PF02367.17 CDW60511.1 - 0.047 13.7 0.7 0.1 12.6 0.0 1.9 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 CDW60511.1 - 0.052 13.3 0.1 1.1 9.0 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 CDW60511.1 - 0.057 13.6 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CDW60511.1 - 0.077 13.3 0.2 0.23 11.7 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CDW60511.1 - 0.11 12.5 0.2 0.25 11.3 0.1 1.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) FeoB_N PF02421.18 CDW60511.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 CDW60511.1 - 0.15 11.8 0.1 0.19 11.4 0.1 1.3 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CDW60511.1 - 0.17 11.1 0.0 0.35 10.0 0.1 1.7 2 0 0 2 2 2 0 NB-ARC domain HCO3_cotransp PF00955.21 CDW60512.1 - 7.3e-69 232.9 8.7 1.1e-68 232.4 8.7 1.3 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 CDW60512.1 - 4.8e-45 154.5 0.1 1.3e-29 103.8 0.0 2.1 1 1 1 2 2 2 2 Band 3 cytoplasmic domain Trypsin PF00089.26 CDW60513.1 - 5.3e-10 39.5 0.1 7.3e-10 39.0 0.1 1.1 1 0 0 1 1 1 1 Trypsin Integrase_H2C2 PF17921.1 CDW60515.1 - 3e-12 46.4 0.0 5.1e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain Histone PF00125.24 CDW60517.1 - 6.3e-11 42.8 0.0 7.4e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 CDW60517.1 - 0.024 15.1 0.0 0.03 14.8 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A GXGXG PF01493.19 CDW60518.1 - 1e-80 269.8 3.5 1.6e-80 269.2 3.5 1.3 1 0 0 1 1 1 1 GXGXG motif Glu_synthase PF01645.17 CDW60518.1 - 3.8e-32 111.8 0.1 5.9e-32 111.2 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase Pyr_redox_2 PF07992.14 CDW60518.1 - 2.2e-23 82.9 0.0 4.7e-23 81.9 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 CDW60518.1 - 5.6e-19 68.0 0.6 5.6e-19 68.0 0.6 1.7 2 0 0 2 2 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 CDW60518.1 - 1.7e-08 34.5 0.1 1.7e-08 34.5 0.1 2.4 3 0 0 3 3 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CDW60518.1 - 1.1e-07 31.4 0.0 0.0023 17.2 0.2 3.1 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDW60518.1 - 3.3e-07 30.0 0.2 1.4e-05 24.6 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CDW60518.1 - 1.3e-06 28.9 0.5 0.0019 18.7 0.2 2.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CDW60518.1 - 7.9e-06 24.8 0.2 0.00011 21.1 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 CDW60518.1 - 1.3e-05 24.7 0.1 3e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FMO-like PF00743.19 CDW60518.1 - 1.7e-05 23.5 0.0 0.12 10.8 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like FAD_binding_2 PF00890.24 CDW60518.1 - 9.4e-05 21.7 0.2 0.00019 20.6 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 CDW60518.1 - 9.7e-05 22.8 0.1 0.12 12.8 0.0 2.6 2 0 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.17 CDW60518.1 - 0.0017 17.6 0.1 0.0034 16.7 0.1 1.4 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CDW60518.1 - 0.0021 17.7 0.1 0.0041 16.7 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CDW60518.1 - 0.0023 17.2 0.1 0.0046 16.3 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain 2-Hacid_dh_C PF02826.19 CDW60518.1 - 0.0093 15.3 0.2 0.14 11.5 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CDW60518.1 - 0.01 15.2 0.7 0.45 9.8 0.1 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 CDW60518.1 - 0.01 15.0 0.0 1.2 8.3 0.0 2.9 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 CDW60518.1 - 0.011 14.8 0.1 0.021 14.0 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_Gly3P_dh_N PF01210.23 CDW60518.1 - 0.041 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Cryptochrome_C PF12546.8 CDW60518.1 - 0.054 14.1 0.6 0.11 13.2 0.6 1.4 1 0 0 1 1 1 0 Blue/Ultraviolet sensing protein C terminal Spermine_synth PF01564.17 CDW60518.1 - 0.07 12.5 0.0 0.87 9.0 0.0 2.1 2 0 0 2 2 2 0 Spermine/spermidine synthase domain ApbA PF02558.16 CDW60518.1 - 0.071 12.8 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 CDW60518.1 - 0.083 11.9 0.3 0.14 11.2 0.3 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 CDW60518.1 - 0.094 12.7 0.4 1.6 8.7 0.1 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Shikimate_DH PF01488.20 CDW60518.1 - 0.13 12.3 0.6 12 6.0 0.0 2.6 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 CDW60518.1 - 0.47 11.1 1.6 9.1 6.9 0.2 3.1 3 0 0 3 3 2 0 NADP oxidoreductase coenzyme F420-dependent RNase_HII PF01351.18 CDW60519.1 - 3.4e-50 170.6 0.0 4.2e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII UBA PF00627.31 CDW60520.1 - 3.5e-25 87.5 0.7 9.3e-12 44.6 0.0 3.0 3 0 0 3 3 3 2 UBA/TS-N domain XPC-binding PF09280.11 CDW60520.1 - 3.5e-19 68.3 6.7 8.3e-19 67.1 6.7 1.7 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 CDW60520.1 - 7.6e-18 64.0 0.3 1.5e-17 63.1 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CDW60520.1 - 4.9e-05 23.4 1.1 0.0001 22.4 1.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 CDW60520.1 - 0.0005 19.8 0.7 0.0011 18.7 0.7 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 CDW60520.1 - 0.0052 16.6 0.0 1.1 9.2 0.0 2.5 2 0 0 2 2 2 1 Fungal ubiquitin-associated domain DUF2407 PF10302.9 CDW60520.1 - 0.0098 16.4 0.1 0.019 15.5 0.1 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Thioredoxin_13 PF18401.1 CDW60520.1 - 0.015 15.2 0.0 0.061 13.2 0.1 1.9 2 0 0 2 2 2 0 Thioredoxin-like domain DUF1421 PF07223.11 CDW60520.1 - 0.039 13.8 0.0 9 6.2 0.0 2.6 2 0 0 2 2 2 0 UBA-like domain (DUF1421) Astacin PF01400.24 CDW60522.1 - 2e-65 220.0 0.1 2.6e-65 219.6 0.1 1.1 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 CDW60522.1 - 5.5e-09 36.4 4.1 1.2e-08 35.3 4.1 1.6 1 0 0 1 1 1 1 ShK domain-like DUF4873 PF16170.5 CDW60522.1 - 0.092 13.0 0.0 0.41 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4873) DUF3592 PF12158.8 CDW60523.1 - 0.016 15.3 0.1 0.027 14.5 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3592) DUF1599 PF07659.11 CDW60525.1 - 1.4e-11 44.7 0.2 5.1e-11 42.9 0.2 2.1 1 0 0 1 1 1 1 Nucleotide modification associated domain 1 Gly_reductase PF09338.11 CDW60525.1 - 0.023 13.1 0.0 0.035 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycine/sarcosine/betaine reductase component B subunits RPA_C PF08784.11 CDW60526.1 - 0.02 15.6 0.0 0.42 11.3 0.1 2.5 2 1 1 3 3 3 0 Replication protein A C terminal HMMR_N PF15905.5 CDW60527.1 - 0.0014 18.2 11.4 0.0014 18.2 11.4 2.1 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal PspA_IM30 PF04012.12 CDW60527.1 - 0.0064 16.1 9.0 0.0064 16.1 9.0 1.7 2 0 0 2 2 2 1 PspA/IM30 family KASH_CCD PF14662.6 CDW60527.1 - 0.008 16.0 14.6 0.008 16.0 14.6 2.1 2 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH Prefoldin PF02996.17 CDW60527.1 - 0.022 14.7 1.0 0.022 14.7 1.0 3.8 4 1 0 4 4 3 0 Prefoldin subunit DUF1722 PF08349.11 CDW60527.1 - 0.085 13.1 11.5 0.11 12.7 0.1 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF1722) TACC_C PF05010.14 CDW60527.1 - 0.14 11.9 20.9 0.91 9.3 1.0 3.0 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TMPIT PF07851.13 CDW60527.1 - 0.15 11.3 16.3 0.25 10.6 10.5 2.3 2 0 0 2 2 2 0 TMPIT-like protein Lebercilin PF15619.6 CDW60527.1 - 0.21 11.2 14.9 0.026 14.2 9.9 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF3800 PF12686.7 CDW60527.1 - 0.25 12.0 6.9 2.5 8.7 7.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF3584 PF12128.8 CDW60527.1 - 0.35 8.3 17.9 0.32 8.5 15.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ATG_C PF09333.11 CDW60527.1 - 0.4 11.1 2.6 21 5.6 0.1 3.9 3 2 1 4 4 4 0 Autophagy-related protein C terminal domain OmpH PF03938.14 CDW60527.1 - 0.4 11.0 30.8 0.24 11.8 6.4 3.8 1 1 3 4 4 4 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 CDW60527.1 - 0.46 9.3 26.5 0.12 11.2 18.9 2.5 1 1 1 3 3 3 0 Spc7 kinetochore protein VPS38 PF17649.1 CDW60527.1 - 0.78 8.5 14.6 0.67 8.8 13.4 1.4 1 1 0 1 1 1 0 Vacuolar protein sorting 38 FapA PF03961.13 CDW60527.1 - 0.87 8.1 14.5 0.083 11.5 8.7 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A Prefoldin_2 PF01920.20 CDW60527.1 - 1 9.3 18.1 0.96 9.4 1.4 3.4 3 0 0 3 3 2 0 Prefoldin subunit DUF713 PF05218.14 CDW60527.1 - 1.1 9.0 15.5 0.54 10.0 8.3 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF713) Peroxin-13_N PF04088.13 CDW60527.1 - 1.2 9.5 5.3 2.8 8.2 1.1 2.6 3 0 0 3 3 2 0 Peroxin 13, N-terminal region GARP PF16731.5 CDW60527.1 - 1.3 8.6 12.2 0.47 10.1 2.9 3.1 2 1 0 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF4763 PF15960.5 CDW60527.1 - 1.5 8.1 14.9 2.3 7.5 10.1 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF4763) TPR_MLP1_2 PF07926.12 CDW60527.1 - 1.9 8.5 18.7 1.4 9.0 14.8 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 CDW60527.1 - 2 7.4 13.1 0.66 9.0 9.9 1.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 CDW60527.1 - 2.7 8.1 13.0 12 6.0 0.1 3.7 3 2 1 4 4 3 0 Protein of unknown function (DUF1664) DUF4854 PF16146.5 CDW60527.1 - 3.3 8.1 12.5 0.48 10.8 0.1 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4854) DUF4455 PF14643.6 CDW60527.1 - 4.6 5.8 19.6 75 1.8 14.5 4.2 2 2 1 4 4 4 0 Domain of unknown function (DUF4455) ZapD PF07072.11 CDW60527.1 - 4.7 6.9 9.5 4.4 7.0 6.8 2.4 2 1 0 2 2 2 0 Cell division protein Med9 PF07544.13 CDW60527.1 - 4.8 7.4 15.5 0.55 10.4 5.0 3.3 2 1 1 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 Syntaxin-6_N PF09177.11 CDW60527.1 - 6.7 7.3 14.6 8.4 7.0 9.0 3.0 2 1 1 3 3 3 0 Syntaxin 6, N-terminal UPF0242 PF06785.11 CDW60527.1 - 7 6.7 18.0 1.6 8.8 12.5 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Sec20 PF03908.13 CDW60527.1 - 7.2 6.6 10.5 1.5 8.8 1.6 3.5 3 1 0 4 4 3 0 Sec20 AATF-Che1 PF13339.6 CDW60527.1 - 7.6 7.2 18.0 1.7 9.3 11.2 2.7 1 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Jnk-SapK_ap_N PF09744.9 CDW60527.1 - 7.9 6.7 20.7 0.52 10.5 8.8 3.0 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 CDW60527.1 - 9.9 5.9 16.7 5.4 6.8 14.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) MRI PF15325.6 CDW60529.1 - 6.4 7.9 7.6 6.7 7.9 0.3 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection Atx10homo_assoc PF09759.9 CDW60530.1 - 2.7e-14 53.0 1.0 1.1e-13 51.1 0.1 2.4 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Metallophos PF00149.28 CDW60531.1 - 1.2e-41 143.5 0.0 1.5e-41 143.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CDW60531.1 - 0.00082 19.8 0.3 0.002 18.5 0.3 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 CDW60531.1 - 0.097 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Glycos_transf_4 PF00953.21 CDW60532.1 - 1e-34 119.8 15.5 1e-34 119.8 15.5 1.9 3 0 0 3 3 3 1 Glycosyl transferase family 4 TUDOR PF00567.24 CDW60534.1 - 1.4e-13 51.0 0.0 3.2e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Tudor domain HAD_2 PF13419.6 CDW60535.1 - 4.5e-28 98.5 0.0 8.4e-28 97.7 0.0 1.4 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW60535.1 - 1.2e-18 68.2 0.0 1.4e-18 67.9 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW60535.1 - 3.9e-11 42.9 0.0 1e-10 41.5 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 CDW60535.1 - 4.7e-09 36.9 0.0 5.6e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDW60535.1 - 0.0001 22.1 0.0 0.038 13.7 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW60535.1 - 0.024 14.7 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CDW60535.1 - 0.1 12.0 0.0 1.5 8.1 0.0 2.0 2 0 0 2 2 2 0 Putative Phosphatase S6PP PF05116.13 CDW60535.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase tRNA-synt_1b PF00579.25 CDW60536.1 - 1.4e-81 274.1 0.0 1.6e-81 273.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) YhfT PF10797.9 CDW60537.1 - 1.6e-162 541.4 29.2 2.2e-162 540.9 29.2 1.2 1 0 0 1 1 1 1 Protein of unknown function Aminotran_1_2 PF00155.21 CDW60537.1 - 1.3e-08 34.5 0.0 2.7e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CDW60537.1 - 3.7e-06 25.7 0.1 5.6e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CDW60537.1 - 0.00017 20.7 0.1 0.00028 19.9 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase PF00069.25 CDW60538.1 - 2.9e-52 177.6 0.0 4.1e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60538.1 - 9.4e-22 77.5 0.0 1.3e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW60538.1 - 2.5e-07 29.8 0.0 3.7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CDW60538.1 - 4.2e-05 23.0 0.0 0.0001 21.7 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CDW60538.1 - 0.00031 20.1 0.0 0.00045 19.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-RRN7 PF11781.8 CDW60538.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Serpin PF00079.20 CDW60539.1 - 6.1e-113 377.9 0.9 7.9e-113 377.5 0.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Flu_B_NS1 PF02942.14 CDW60539.1 - 0.079 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) DUF2431 PF10354.9 CDW60540.1 - 3.5e-29 102.2 0.0 5.9e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) FDX-ACB PF03147.14 CDW60540.1 - 8.1e-05 23.0 0.0 0.00018 21.8 0.0 1.5 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain Pyr_redox PF00070.27 CDW60540.1 - 0.12 12.9 0.1 0.27 11.8 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Transposase_mut PF00872.18 CDW60541.1 - 8.5e-103 344.1 0.0 1e-102 343.9 0.0 1.0 1 0 0 1 1 1 1 Transposase, Mutator family MULE PF10551.9 CDW60541.1 - 3.4e-06 27.4 0.0 9.4e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 MULE transposase domain FMN_dh PF01070.18 CDW60542.1 - 1.5e-109 366.2 0.0 1.8e-109 366.0 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CDW60542.1 - 0.00042 19.4 0.6 0.0032 16.5 0.1 2.4 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CDW60542.1 - 0.0048 16.4 0.1 0.28 10.6 0.0 2.6 2 1 1 3 3 3 1 Histidine biosynthesis protein ThiG PF05690.14 CDW60542.1 - 0.011 15.1 0.0 0.72 9.1 0.0 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Ribosomal_L27e PF01777.18 CDW60543.1 - 3.8e-30 104.1 8.8 5e-30 103.7 8.8 1.2 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 CDW60543.1 - 0.00016 21.5 0.0 0.00038 20.3 0.0 1.6 1 0 0 1 1 1 1 KOW motif GDC-P PF02347.16 CDW60544.1 - 4.4e-118 394.8 0.0 5e-118 394.7 0.0 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein SPO11_like PF03533.14 CDW60544.1 - 0.09 12.9 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 SPO11 homologue FLYWCH PF04500.16 CDW60545.1 - 2e-11 43.9 5.4 3e-11 43.3 5.4 1.3 1 0 0 1 1 1 1 FLYWCH zinc finger domain G2F PF07474.12 CDW60545.1 - 0.078 12.8 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 G2F domain DUF1936 PF09151.10 CDW60545.1 - 0.16 11.9 1.4 0.2 11.6 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) FSAP_sig_propep PF03032.15 CDW60546.1 - 0.049 13.7 0.1 0.078 13.0 0.1 1.4 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide Cystatin PF00031.21 CDW60547.1 - 3.4e-09 36.8 0.1 3.8e-09 36.7 0.1 1.0 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 CDW60547.1 - 3.3e-05 24.1 0.2 3.6e-05 24.0 0.2 1.1 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 CDW60548.1 - 3.8e-12 46.3 0.0 4.7e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 CDW60548.1 - 0.00018 21.8 0.3 0.00025 21.3 0.3 1.2 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 CDW60549.1 - 2.3e-23 82.2 0.1 7.8e-11 42.1 0.0 2.0 2 0 0 2 2 2 2 Cystatin domain SQAPI PF16845.5 CDW60549.1 - 4.9e-10 39.6 0.8 0.00099 19.4 0.0 2.1 2 0 0 2 2 2 2 Aspartic acid proteinase inhibitor HTH_1 PF00126.27 CDW60550.1 - 2.7e-18 65.7 0.0 5e-18 64.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family LysR_substrate PF03466.20 CDW60550.1 - 2.7e-16 59.6 0.0 4.2e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 LysR substrate binding domain TPP_enzyme_N PF02776.18 CDW60551.1 - 1.2e-59 200.8 0.5 3.7e-56 189.4 0.2 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CDW60551.1 - 2.9e-49 166.8 0.2 3.2e-47 160.1 0.0 3.2 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CDW60551.1 - 2.1e-47 160.3 0.1 4.2e-47 159.3 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 CDW60551.1 - 0.0049 16.6 0.1 0.011 15.5 0.1 1.6 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg ROQ_II PF18386.1 CDW60551.1 - 0.12 12.2 0.3 0.29 11.0 0.3 1.6 1 0 0 1 1 1 0 Roquin II domain ALS_ss_C PF10369.9 CDW60552.1 - 2.1e-19 69.5 1.1 5.2e-19 68.2 0.1 2.1 2 0 0 2 2 2 1 Small subunit of acetolactate synthase LacI PF00356.21 CDW60552.1 - 7.9e-19 67.2 0.8 7.9e-19 67.2 0.8 2.3 2 0 0 2 2 2 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.21 CDW60552.1 - 8.3e-14 51.7 0.0 1.2e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Peripla_BP_3 PF13377.6 CDW60552.1 - 1.8e-10 41.4 0.1 2.7e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 Periplasmic binding protein-like domain Peripla_BP_4 PF13407.6 CDW60552.1 - 3.9e-09 36.5 0.0 5.3e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein domain ACT_5 PF13710.6 CDW60552.1 - 0.00079 19.2 1.3 0.24 11.3 0.6 2.9 2 0 0 2 2 2 2 ACT domain DUF4543 PF15076.6 CDW60552.1 - 0.0028 17.8 0.2 0.0099 16.0 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4543) HTH_3 PF01381.22 CDW60552.1 - 0.028 14.5 0.0 0.11 12.6 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix LysR_substrate PF03466.20 CDW60552.1 - 0.055 12.8 1.5 5.6 6.3 0.0 3.1 2 1 0 3 3 3 0 LysR substrate binding domain Methyltransf_5 PF01795.19 CDW60553.1 - 5.5e-124 413.7 0.0 6.2e-124 413.5 0.0 1.0 1 0 0 1 1 1 1 MraW methylase family Methyltransf_31 PF13847.6 CDW60553.1 - 0.0027 17.5 0.0 0.16 11.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW60553.1 - 0.0061 17.2 0.0 1.6 9.5 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_24 PF13578.6 CDW60553.1 - 0.011 16.7 0.0 0.43 11.6 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 CDW60553.1 - 0.026 15.2 0.0 7.8 7.2 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain Transpeptidase PF00905.22 CDW60554.1 - 5.1e-84 282.1 0.1 6.4e-84 281.7 0.1 1.1 1 0 0 1 1 1 1 Penicillin binding protein transpeptidase domain FtsL PF04999.13 CDW60554.1 - 4e-33 113.3 0.0 7.5e-33 112.4 0.0 1.4 1 0 0 1 1 1 1 Cell division protein FtsL PBP_dimer PF03717.15 CDW60554.1 - 9.2e-23 81.5 0.0 2.8e-21 76.7 0.0 2.3 1 1 0 1 1 1 1 Penicillin-binding Protein dimerisation domain DUF1616 PF07760.11 CDW60554.1 - 0.083 12.3 0.1 0.2 11.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) DivIC PF04977.15 CDW60554.1 - 0.16 11.7 0.1 0.32 10.8 0.1 1.4 1 0 0 1 1 1 0 Septum formation initiator Claudin_3 PF06653.11 CDW60555.1 - 9.6e-06 25.6 8.8 1.8e-05 24.7 8.8 1.5 1 1 0 1 1 1 1 Tight junction protein, Claudin-like Atthog PF18800.1 CDW60555.1 - 0.00081 19.3 3.5 0.02 14.8 0.2 2.4 1 1 1 2 2 2 2 Attenuator of Hedgehog DUF2157 PF09925.9 CDW60555.1 - 0.068 13.0 3.6 0.084 12.7 1.4 2.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Claudin_2 PF13903.6 CDW60555.1 - 0.14 11.9 10.8 0.082 12.7 7.0 2.3 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Acetyltransf_1 PF00583.25 CDW60556.1 - 1.1e-09 38.5 0.0 3.3e-09 37.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CDW60556.1 - 0.0011 19.6 0.1 0.0015 19.2 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CDW60556.1 - 0.0024 17.8 0.0 0.0055 16.6 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 CDW60556.1 - 0.01 16.2 0.0 0.024 15.1 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CDW60556.1 - 0.033 14.1 0.1 0.082 12.9 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain rve PF00665.26 CDW60558.1 - 1.9e-06 28.1 0.0 2.1e-06 27.9 0.0 1.0 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDW60559.1 - 6.2e-14 51.9 0.2 1.2e-13 50.9 0.2 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH_2 PF17919.1 CDW60559.1 - 1.2e-08 34.9 0.0 3.1e-08 33.5 0.0 1.8 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDW60559.1 - 3.3e-07 30.5 0.0 0.003 17.8 0.0 2.4 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase zf-H2C2 PF09337.10 CDW60559.1 - 0.0097 16.1 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger PDEase_I PF00233.19 CDW60560.1 - 1.4e-32 113.4 1.5 1.4e-32 113.4 1.5 1.8 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GYF_2 PF14237.6 CDW60561.1 - 6.4e-07 29.1 0.0 1.8e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 GYF domain 2 MMS19_C PF12460.8 CDW60562.1 - 0.0086 15.2 0.0 0.0086 15.2 0.0 1.3 1 1 0 1 1 1 1 RNAPII transcription regulator C-terminal Ovate PF04844.13 CDW60562.1 - 0.095 12.7 0.5 0.67 10.0 0.0 2.5 3 0 0 3 3 3 0 Transcriptional repressor, ovate TTR-52 PF01060.23 CDW60563.1 - 1.5e-14 54.4 0.0 2.1e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family DUF1679 PF07914.11 CDW60564.1 - 5.1e-31 107.9 0.0 2.3e-20 72.9 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1679) EcKinase PF02958.20 CDW60564.1 - 1.5e-23 83.5 0.0 3.2e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 CDW60564.1 - 6.5e-12 45.9 0.1 1.2e-11 45.0 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW60564.1 - 0.1 11.9 0.0 0.39 10.0 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fructosamin_kin PF03881.14 CDW60564.1 - 0.17 11.1 0.2 0.4 9.8 0.1 1.8 2 1 0 2 2 2 0 Fructosamine kinase Choline_kinase PF01633.20 CDW60564.1 - 0.18 11.4 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_L5e PF17144.4 CDW60565.1 - 1.1e-84 282.4 2.6 1.1e-84 282.4 2.6 1.7 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CDW60565.1 - 3.3e-31 108.1 9.4 8.8e-31 106.7 9.4 1.7 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 CDW60565.1 - 0.01 16.2 0.1 0.01 16.2 0.1 2.1 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast zf-CCHC PF00098.23 CDW60566.1 - 0.00087 19.3 3.5 0.082 13.0 0.8 2.6 2 0 0 2 2 2 2 Zinc knuckle Asp_protease_2 PF13650.6 CDW60566.1 - 0.0026 18.3 0.0 0.0056 17.3 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW60566.1 - 0.058 14.0 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease PolC_DP2 PF03833.13 CDW60566.1 - 0.075 10.9 1.2 0.096 10.5 1.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-CCHC_3 PF13917.6 CDW60566.1 - 0.14 12.2 2.8 0.6 10.1 0.7 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 CDW60566.1 - 0.65 9.8 12.7 1.5 8.6 2.1 2.3 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger ShK PF01549.24 CDW60568.1 - 8.8e-08 32.6 7.4 2.3e-07 31.2 6.5 1.9 1 1 1 2 2 2 2 ShK domain-like O-FucT PF10250.9 CDW60569.1 - 1e-14 55.0 0.0 1.2e-14 54.8 0.0 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DEK_C PF08766.11 CDW60570.1 - 2.4e-14 53.0 2.5 2.4e-14 53.0 2.5 1.5 2 0 0 2 2 2 1 DEK C terminal domain CCDC50_N PF15295.6 CDW60570.1 - 0.009 16.2 1.9 0.094 12.9 0.2 2.1 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 50 N-terminus SRP54_N PF02881.19 CDW60570.1 - 0.086 13.1 1.0 0.086 13.1 1.0 2.0 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain DUF4661 PF15576.6 CDW60570.1 - 0.22 11.4 5.6 0.16 11.8 4.0 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4661) DUF4663 PF15668.5 CDW60571.1 - 5e-11 42.2 0.0 7.5e-07 28.5 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4663) MVL PF12151.8 CDW60571.1 - 0.17 11.7 0.2 4.5 7.2 0.0 2.5 2 0 0 2 2 2 0 Mannan-binding protein Pkinase_Tyr PF07714.17 CDW60573.1 - 2.9e-59 200.5 0.0 4.2e-59 199.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CDW60573.1 - 2.4e-39 135.3 0.0 4.4e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 CDW60573.1 - 3.8e-13 49.3 0.1 9e-13 48.1 0.1 1.7 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 CDW60573.1 - 0.024 14.1 0.0 0.058 12.8 0.0 1.7 1 0 0 1 1 1 0 SH2 domain U3snoRNP10 PF12397.8 CDW60574.1 - 8.5e-08 32.6 1.3 1.9e-07 31.5 1.3 1.6 1 0 0 1 1 1 1 U3 small nucleolar RNA-associated protein 10 Pkinase PF00069.25 CDW60575.1 - 4.1e-26 91.9 0.0 5.2e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60575.1 - 8.9e-14 51.4 0.0 1.2e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CDW60575.1 - 0.0067 15.8 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CDW60575.1 - 0.02 14.8 0.0 0.082 12.8 0.0 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CDW60575.1 - 0.023 13.5 0.0 0.03 13.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase DUF229 PF02995.17 CDW60576.1 - 2.4e-121 405.8 0.0 3.2e-121 405.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 CDW60576.1 - 0.005 16.5 0.0 2.4 7.7 0.0 2.4 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CDW60576.1 - 0.0067 15.8 0.3 0.11 11.8 0.0 2.4 1 1 1 2 2 2 1 Sulfatase Wzy_C_2 PF11846.8 CDW60576.1 - 0.041 13.8 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal Pkinase PF00069.25 CDW60577.1 - 3.2e-14 52.9 0.0 9e-14 51.5 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain AdenylateSensor PF16579.5 CDW60577.1 - 1.1e-11 45.2 1.2 7.9e-11 42.4 0.4 2.4 2 1 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 CDW60577.1 - 0.00061 19.1 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW60577.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like UBA_2 PF08587.11 CDW60577.1 - 0.15 12.2 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) Tex_YqgF PF16921.5 CDW60580.1 - 8.5e-33 113.5 0.0 2.6e-32 111.9 0.0 1.8 2 0 0 2 2 2 1 Tex protein YqgF-like domain HHH_3 PF12836.7 CDW60580.1 - 2.5e-19 69.3 0.0 4.2e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_7 PF14635.6 CDW60580.1 - 5.8e-08 33.0 0.0 1.1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 CDW60580.1 - 5.3e-06 27.3 0.2 1.1e-05 26.2 0.2 1.6 1 0 0 1 1 1 1 HHH domain YqgF PF14639.6 CDW60580.1 - 0.0031 17.3 0.0 0.0067 16.2 0.0 1.6 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 Cullin PF00888.22 CDW60581.1 - 7.1e-38 130.6 0.1 8.2e-38 130.4 0.1 1.0 1 0 0 1 1 1 1 Cullin family T4SS PF07996.11 CDW60581.1 - 0.11 12.8 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion system proteins EGF_CA PF07645.15 CDW60583.1 - 1e-16 60.8 24.2 1.7e-10 40.9 7.3 2.6 2 0 0 2 2 2 2 Calcium-binding EGF domain EGF_3 PF12947.7 CDW60583.1 - 4.5e-06 26.8 24.6 2e-05 24.7 6.9 2.8 2 0 0 2 2 2 2 EGF domain hEGF PF12661.7 CDW60583.1 - 1.2e-05 25.7 20.9 4e-05 24.1 4.1 3.5 3 1 0 3 3 3 2 Human growth factor-like EGF EGF PF00008.27 CDW60583.1 - 0.00072 19.8 27.2 0.0056 17.0 9.1 3.2 3 0 0 3 3 3 2 EGF-like domain FXa_inhibition PF14670.6 CDW60583.1 - 0.01 16.1 20.9 0.012 15.9 7.1 3.0 1 1 1 2 2 2 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW60583.1 - 0.03 14.2 1.5 0.03 14.2 1.5 4.9 5 1 0 5 5 5 0 Complement Clr-like EGF-like EGF_2 PF07974.13 CDW60583.1 - 0.26 11.7 19.2 0.26 11.7 6.3 2.9 2 0 0 2 2 2 0 EGF-like domain TILa PF12714.7 CDW60583.1 - 0.96 9.5 16.6 4.4 7.3 3.1 2.8 2 0 0 2 2 2 0 TILa domain EGF_MSP1_1 PF12946.7 CDW60583.1 - 2.7 8.1 14.5 0.6 10.2 3.4 2.7 2 0 0 2 2 2 0 MSP1 EGF domain 1 Neur_chan_LBD PF02931.23 CDW60584.1 - 1e-28 100.3 0.6 1.3e-28 99.9 0.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain zf-like PF04071.12 CDW60584.1 - 0.05 13.5 0.1 0.1 12.6 0.1 1.5 1 0 0 1 1 1 0 Cysteine-rich small domain INCENP_ARK-bind PF03941.15 CDW60585.1 - 2.6e-08 33.7 0.2 6.8e-08 32.3 0.2 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region RasGEF PF00617.19 CDW60586.1 - 1.6e-47 162.0 0.3 2.7e-47 161.2 0.3 1.4 1 0 0 1 1 1 1 RasGEF domain PB1 PF00564.24 CDW60586.1 - 0.14 12.1 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 PB1 domain LIAS_N PF16881.5 CDW60587.1 - 5.1e-21 75.1 0.1 1e-20 74.2 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 CDW60587.1 - 8.3e-13 49.1 0.1 1.5e-12 48.2 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Trypsin PF00089.26 CDW60588.1 - 4.5e-43 147.6 0.0 4.5e-42 144.3 0.0 1.9 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 CDW60588.1 - 6.8e-07 30.3 0.0 1e-06 29.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 CDW60588.1 - 0.1 13.0 0.2 8.9 6.7 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1986) Dimer_Tnp_hAT PF05699.14 CDW60589.1 - 0.00098 18.9 0.1 0.0035 17.1 0.0 1.9 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region PRD PF00874.20 CDW60589.1 - 0.014 15.7 1.0 3.8 7.9 0.0 3.2 3 1 1 4 4 4 0 PRD domain P2_Phage_GpR PF06891.11 CDW60589.1 - 0.11 12.6 0.1 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 P2 phage tail completion protein R (GpR) HTH_6 PF01418.17 CDW60590.1 - 6.9e-25 86.8 0.1 1.4e-24 85.8 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain, rpiR family SIS PF01380.22 CDW60590.1 - 1.4e-17 63.8 0.1 3.1e-17 62.6 0.1 1.5 1 0 0 1 1 1 1 SIS domain EIID-AGA PF03613.14 CDW60590.1 - 2.1e-11 43.5 0.4 3.2e-11 42.9 0.4 1.4 1 0 0 1 1 1 1 PTS system mannose/fructose/sorbose family IID component EIIA-man PF03610.16 CDW60590.1 - 2.6e-09 37.3 0.5 2.6e-09 37.3 0.5 2.2 3 0 0 3 3 3 1 PTS system fructose IIA component SIS_2 PF13580.6 CDW60590.1 - 2e-07 31.1 0.3 2.6e-05 24.3 0.3 2.5 1 1 1 2 2 2 1 SIS domain RWP-RK PF02042.15 CDW60590.1 - 0.17 11.9 0.1 5.5 7.1 0.0 2.5 2 0 0 2 2 2 0 RWP-RK domain HTH_7 PF02796.15 CDW60590.1 - 0.19 11.9 0.8 12 6.0 0.1 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain of resolvase Cupin_2 PF07883.11 CDW60591.1 - 3.8e-07 29.7 0.1 7.3e-07 28.8 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CDW60591.1 - 8.1e-07 29.0 0.5 1.4e-06 28.3 0.5 1.5 1 1 0 1 1 1 1 AraC-like ligand binding domain HTH_18 PF12833.7 CDW60591.1 - 2e-05 24.8 0.0 8.3e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain Sugar-bind PF04198.13 CDW60592.1 - 1.8e-57 194.4 0.1 2.2e-57 194.1 0.1 1.1 1 0 0 1 1 1 1 Putative sugar-binding domain Sigma70_r4 PF04545.16 CDW60592.1 - 4.4e-07 29.3 0.1 1e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_r4_2 PF08281.12 CDW60592.1 - 4e-06 26.4 0.2 4e-06 26.4 0.2 2.0 3 0 0 3 3 1 1 Sigma-70, region 4 HTH_24 PF13412.6 CDW60592.1 - 7.1e-06 25.5 0.0 2.1e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 CDW60592.1 - 1.3e-05 24.9 0.0 3.9e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 CDW60592.1 - 2.8e-05 24.2 0.0 6.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 CDW60592.1 - 3.3e-05 23.8 0.0 8.3e-05 22.5 0.0 1.7 2 0 0 2 2 1 1 Winged helix-turn helix MarR PF01047.22 CDW60592.1 - 5.8e-05 22.9 0.1 0.00024 21.0 0.0 2.1 1 1 1 2 2 2 1 MarR family TrmB PF01978.19 CDW60592.1 - 6.7e-05 22.7 0.1 0.00023 21.0 0.1 1.9 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 CDW60592.1 - 8.8e-05 22.3 0.0 0.00018 21.3 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 CDW60592.1 - 0.00045 20.1 0.1 0.00098 19.1 0.1 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_10 PF04967.12 CDW60592.1 - 0.0014 18.4 0.1 0.0044 16.8 0.1 2.0 1 0 0 1 1 1 1 HTH DNA binding domain HTH_37 PF13744.6 CDW60592.1 - 0.0036 17.2 0.7 0.037 14.0 0.1 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_11 PF08279.12 CDW60592.1 - 0.0039 17.1 0.2 0.012 15.6 0.2 1.9 1 0 0 1 1 1 1 HTH domain HTH_36 PF13730.6 CDW60592.1 - 0.0088 16.0 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.20 CDW60592.1 - 0.012 16.0 0.2 0.029 14.7 0.2 1.6 1 0 0 1 1 1 0 Transcriptional regulator HTH_40 PF14493.6 CDW60592.1 - 0.013 15.9 4.4 0.035 14.5 1.4 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain GerE PF00196.19 CDW60592.1 - 0.029 13.9 0.2 0.15 11.6 0.0 2.2 3 0 0 3 3 2 0 Bacterial regulatory proteins, luxR family DUF134 PF02001.16 CDW60592.1 - 0.034 14.7 0.2 0.13 12.8 0.0 2.1 3 0 0 3 3 1 0 Protein of unknown function DUF134 HTH_IclR PF09339.10 CDW60592.1 - 0.036 13.9 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain Fe_dep_repress PF01325.19 CDW60592.1 - 0.037 14.2 0.1 0.11 12.7 0.1 1.7 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_3 PF01381.22 CDW60592.1 - 0.05 13.7 0.0 0.19 11.8 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix HTH_38 PF13936.6 CDW60592.1 - 0.061 13.1 0.0 0.22 11.3 0.0 2.0 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r3 PF04539.16 CDW60592.1 - 0.08 13.0 0.1 0.08 13.0 0.1 1.8 2 0 0 2 2 1 0 Sigma-70 region 3 HTH_7 PF02796.15 CDW60592.1 - 0.1 12.7 0.0 0.44 10.7 0.0 2.2 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HTH_30 PF13556.6 CDW60592.1 - 0.11 12.3 0.1 0.34 10.8 0.0 1.8 2 0 0 2 2 1 0 PucR C-terminal helix-turn-helix domain GntR PF00392.21 CDW60592.1 - 0.12 12.1 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family TFIIE_alpha PF02002.17 CDW60592.1 - 1.9 8.4 6.9 0.099 12.5 0.4 2.3 3 0 0 3 3 2 0 TFIIE alpha subunit F_bP_aldolase PF01116.20 CDW60593.1 - 6e-81 272.0 2.1 1e-80 271.2 0.4 1.9 2 0 0 2 2 2 1 Fructose-bisphosphate aldolase class-II UPF0047 PF01894.17 CDW60593.1 - 2.3e-13 50.3 0.0 6.6e-13 48.8 0.0 1.8 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 TIM PF00121.18 CDW60593.1 - 2.2e-07 30.5 0.0 5.5e-05 22.7 0.0 2.9 2 1 1 3 3 3 1 Triosephosphate isomerase ThiG PF05690.14 CDW60593.1 - 5.5e-05 22.6 10.7 0.00071 19.0 3.2 3.6 3 1 1 4 4 4 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 CDW60593.1 - 0.0008 18.9 3.2 0.0015 18.0 2.1 1.9 2 0 0 2 2 2 1 Nitronate monooxygenase AP_endonuc_2 PF01261.24 CDW60593.1 - 0.014 14.9 0.9 1.7 8.1 0.5 3.1 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel PEP_mutase PF13714.6 CDW60593.1 - 0.017 14.6 0.6 2.4 7.5 0.1 3.0 3 0 0 3 3 3 0 Phosphoenolpyruvate phosphomutase DUF1059 PF06348.11 CDW60593.1 - 0.14 12.4 0.0 0.54 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) CutC PF03932.14 CDW60593.1 - 0.23 10.9 2.5 2.9 7.3 0.0 3.1 2 2 1 3 3 3 0 CutC family PEP_hydrolase PF09370.10 CDW60593.1 - 0.32 10.2 3.4 0.46 9.7 0.8 2.3 2 1 0 2 2 2 0 Phosphoenolpyruvate hydrolase-like GatD_N PF18195.1 CDW60594.1 - 0.042 13.2 0.1 3.9 6.9 0.2 2.4 2 0 0 2 2 2 0 GatD N-terminal domain DUF973 PF06157.11 CDW60594.1 - 0.061 12.4 0.1 0.061 12.4 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF973) LSR PF05624.14 CDW60594.1 - 0.16 12.0 1.1 0.42 10.6 1.1 1.7 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) GMP_PDE_delta PF05351.11 CDW60596.1 - 1.7e-73 245.9 1.1 2.4e-73 245.4 1.1 1.2 1 0 0 1 1 1 1 GMP-PDE, delta subunit Histone PF00125.24 CDW60597.1 - 0.0033 17.8 0.0 0.0043 17.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DNA_pol_D_N PF18018.1 CDW60598.1 - 2.3e-18 66.5 3.3 2.3e-17 63.3 2.7 2.0 1 1 1 2 2 2 1 DNA polymerase delta subunit OB-fold domain Ten1 PF12658.7 CDW60598.1 - 0.082 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Telomere capping, CST complex subunit Styelin PF17562.2 CDW60600.1 - 0.39 11.1 1.7 1.7 9.1 0.3 2.1 2 0 0 2 2 2 0 Styelin Lig_chan-Glu_bd PF10613.9 CDW60601.1 - 1.1e-18 67.5 0.0 2e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 CDW60601.1 - 9e-05 22.0 0.0 0.00083 18.8 0.0 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 EGF_2 PF07974.13 CDW60602.1 - 3.5e-08 33.7 59.1 0.00011 22.4 6.2 5.1 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 CDW60602.1 - 1.2e-05 25.4 53.3 0.0075 16.6 7.4 5.7 5 1 0 5 5 5 4 EGF-like domain hEGF PF12661.7 CDW60602.1 - 0.0069 17.0 2.6 0.0069 17.0 2.6 5.8 5 0 0 5 5 5 3 Human growth factor-like EGF Peptidase_A17 PF05380.13 CDW60603.1 - 4.1e-58 196.0 0.6 8.7e-58 194.9 0.3 1.8 2 0 0 2 2 2 1 Pao retrotransposon peptidase DUF1759 PF03564.15 CDW60603.1 - 8.2e-31 106.9 0.2 7.6e-30 103.8 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 CDW60603.1 - 4.2e-16 59.1 0.0 1.3e-15 57.5 0.0 1.8 2 0 0 2 2 2 1 Putative peptidase (DUF1758) RVT_1 PF00078.27 CDW60603.1 - 2.8e-06 27.0 0.0 5.5e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Asp_protease_2 PF13650.6 CDW60603.1 - 0.00057 20.5 0.0 0.0062 17.2 0.0 2.3 2 0 0 2 2 2 1 Aspartyl protease Copper-fist PF00649.18 CDW60603.1 - 0.017 14.6 0.3 0.017 14.6 0.3 2.8 3 0 0 3 3 3 0 Copper fist DNA binding domain Mating_N PF12731.7 CDW60603.1 - 0.033 14.3 0.7 0.96 9.6 0.2 3.0 2 0 0 2 2 2 0 Mating-type protein beta 1 gag-asp_proteas PF13975.6 CDW60603.1 - 0.088 13.4 0.2 0.78 10.3 0.1 2.3 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Integrase_H2C2 PF17921.1 CDW60604.1 - 2.3e-10 40.4 0.1 3.2e-10 39.9 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDW60604.1 - 8.8e-06 25.8 1.9 1.3e-05 25.3 1.9 1.3 1 0 0 1 1 1 1 H2C2 zinc finger Serpin PF00079.20 CDW60605.1 - 3.5e-110 368.8 1.4 4.1e-110 368.6 1.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DUF4371 PF14291.6 CDW60606.1 - 0.00065 19.4 0.0 0.0017 18.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4371) Dimer_Tnp_hAT PF05699.14 CDW60606.1 - 0.0012 18.6 0.0 0.034 13.9 0.0 3.0 3 0 0 3 3 3 1 hAT family C-terminal dimerisation region PRD PF00874.20 CDW60606.1 - 0.018 15.3 1.0 12 6.3 0.0 4.2 4 1 0 4 4 4 0 PRD domain HTH_11 PF08279.12 CDW60606.1 - 0.038 13.9 0.8 7.7 6.5 0.1 2.6 2 0 0 2 2 2 0 HTH domain zf-BED PF02892.15 CDW60606.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 BED zinc finger Sdh5 PF03937.16 CDW60608.1 - 2.7e-25 88.1 0.4 3.1e-25 87.9 0.4 1.0 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase YbjN PF10722.9 CDW60608.1 - 0.0045 17.1 0.0 0.0051 16.9 0.0 1.1 1 0 0 1 1 1 1 Putative bacterial sensory transduction regulator RE_XamI PF09572.10 CDW60608.1 - 0.041 13.6 0.0 0.046 13.4 0.0 1.1 1 0 0 1 1 1 0 XamI restriction endonuclease Glyco_hydro_1 PF00232.18 CDW60609.1 - 3.2e-132 441.2 2.1 3.7e-132 441.0 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.18 CDW60609.1 - 0.0018 17.7 0.1 0.0029 17.1 0.1 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) HlyIII PF03006.20 CDW60610.1 - 2.2e-37 128.9 20.5 2.6e-37 128.7 20.5 1.0 1 0 0 1 1 1 1 Haemolysin-III related CD52 PF15116.6 CDW60610.1 - 7.3 6.7 8.1 0.17 12.0 0.6 2.1 3 0 0 3 3 3 0 CAMPATH-1 antigen GDC-P PF02347.16 CDW60611.1 - 4e-205 681.6 5.1 8.1e-194 644.4 2.3 3.0 2 1 0 2 2 2 2 Glycine cleavage system P-protein GCV_H PF01597.19 CDW60611.1 - 2.6e-38 130.6 0.0 6.2e-38 129.4 0.0 1.7 1 0 0 1 1 1 1 Glycine cleavage H-protein Beta_elim_lyase PF01212.21 CDW60611.1 - 1.1e-06 28.2 0.6 2.3e-06 27.1 0.1 1.8 2 0 0 2 2 2 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CDW60611.1 - 0.00026 20.1 0.9 0.014 14.4 0.1 2.4 2 0 0 2 2 2 2 Aminotransferase class-V RnfC_N PF13375.6 CDW60611.1 - 0.012 15.5 0.0 0.041 13.8 0.0 1.9 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 CDW60611.1 - 0.039 13.8 0.9 0.084 12.7 0.1 1.9 2 0 0 2 2 2 0 Biotin-requiring enzyme GCV_T_C PF08669.11 CDW60612.1 - 2.3e-12 46.7 0.0 2.4e-12 46.6 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain LUD_dom PF02589.15 CDW60613.1 - 2.1e-84 281.9 0.3 2e-54 184.2 0.1 2.3 2 0 0 2 2 2 2 LUD domain CCG PF02754.16 CDW60613.1 - 6.5e-23 80.7 0.6 6.3e-11 42.4 0.0 3.2 3 0 0 3 3 2 2 Cysteine-rich domain Fer4_8 PF13183.6 CDW60613.1 - 7.9e-12 45.5 1.2 2.2e-11 44.0 1.2 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain DUF3390 PF11870.8 CDW60613.1 - 1.9e-08 34.5 0.2 4.2e-08 33.5 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3390) Fer4_10 PF13237.6 CDW60613.1 - 2.4e-07 30.7 8.6 6.5e-06 26.2 9.8 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 CDW60613.1 - 5.4e-07 30.1 2.4 2e-06 28.3 2.4 2.1 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 CDW60613.1 - 1.8e-06 28.0 1.8 6.7e-06 26.2 1.9 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 CDW60613.1 - 1.2e-05 25.8 7.4 4.3e-05 24.0 7.4 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 CDW60613.1 - 0.00018 21.4 12.8 0.0015 18.5 2.9 2.8 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4 PF00037.27 CDW60613.1 - 0.00019 21.1 12.8 0.001 18.8 2.0 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain 14-3-3 PF00244.20 CDW60613.1 - 0.005 16.4 0.3 0.0095 15.5 0.3 1.4 1 0 0 1 1 1 1 14-3-3 protein Fer4_4 PF12800.7 CDW60613.1 - 0.01 16.3 2.2 0.01 16.3 2.2 2.9 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 CDW60613.1 - 0.012 15.6 2.9 0.012 15.6 2.9 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_16 PF13484.6 CDW60613.1 - 0.057 14.4 11.8 0.57 11.2 12.0 2.4 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain Herpes_UL25 PF01499.16 CDW60613.1 - 0.13 10.7 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Fer4_18 PF13746.6 CDW60613.1 - 0.15 12.2 3.7 8.8 6.6 0.2 2.7 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 CDW60613.1 - 0.42 10.8 12.9 7.2 6.8 12.9 2.8 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 CDW60613.1 - 0.54 11.3 16.1 1.8 9.7 4.2 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain HTH_18 PF12833.7 CDW60614.1 - 1.2e-20 73.5 0.4 3.8e-20 71.9 0.2 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain Cupin_6 PF12852.7 CDW60614.1 - 1.7e-19 70.3 0.3 1.9e-18 66.8 0.3 2.2 1 1 0 1 1 1 1 Cupin HTH_AraC PF00165.23 CDW60614.1 - 4.7e-15 55.2 0.0 4.1e-07 29.9 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family AraC_binding PF02311.19 CDW60614.1 - 4.3e-05 23.4 0.1 0.00011 22.1 0.0 1.8 2 1 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 CDW60614.1 - 0.022 14.5 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Cupin domain Pyr_redox_2 PF07992.14 CDW60615.1 - 2e-56 191.4 0.3 3e-56 190.8 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DUF417 PF04224.12 CDW60615.1 - 3.5e-53 179.7 0.0 6.3e-53 178.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF417 Pyr_redox PF00070.27 CDW60615.1 - 9.3e-23 80.6 0.7 4e-20 72.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HTH_18 PF12833.7 CDW60615.1 - 5.2e-20 71.5 0.9 1.3e-19 70.3 0.9 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_AraC PF00165.23 CDW60615.1 - 1.7e-15 56.6 0.3 4.9e-10 39.2 0.1 2.6 2 0 0 2 2 2 2 Bacterial regulatory helix-turn-helix proteins, AraC family Pyr_redox_dim PF02852.22 CDW60615.1 - 7.7e-11 42.2 0.0 1.6e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 CDW60615.1 - 3.7e-08 33.0 0.2 1.6e-06 27.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CDW60615.1 - 2e-07 31.1 0.5 0.00069 19.5 0.0 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 CDW60615.1 - 4.1e-07 29.1 0.1 0.0024 16.6 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein GyrI-like PF06445.15 CDW60615.1 - 8e-07 29.5 0.1 1.8e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 GyrI-like small molecule binding domain DAO PF01266.24 CDW60615.1 - 6e-05 22.8 3.9 0.57 9.7 0.1 3.4 2 1 1 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 CDW60615.1 - 8.2e-05 21.9 2.5 0.0025 17.0 0.9 2.8 2 1 1 3 3 3 1 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CDW60615.1 - 0.00023 20.6 1.7 0.15 11.4 0.3 2.9 3 1 0 3 3 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CDW60615.1 - 0.0023 18.1 1.0 0.24 11.7 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CDW60615.1 - 0.0036 16.6 0.6 0.0085 15.3 0.0 2.0 2 0 0 2 2 2 1 Thi4 family TrkA_N PF02254.18 CDW60615.1 - 0.0053 17.0 0.2 0.048 13.9 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain FAD_binding_2 PF00890.24 CDW60615.1 - 0.0061 15.7 2.5 0.013 14.6 0.5 2.1 2 0 0 2 2 2 1 FAD binding domain UDPG_MGDP_dh_N PF03721.14 CDW60615.1 - 0.0087 15.6 1.4 0.38 10.3 0.2 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 CDW60615.1 - 0.011 15.1 0.3 0.062 12.5 0.1 2.1 2 0 0 2 2 2 0 FAD binding domain XdhC_C PF13478.6 CDW60615.1 - 0.014 15.9 0.2 3.4 8.2 0.0 2.5 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_binding_7 PF13241.6 CDW60615.1 - 0.016 15.7 0.0 4.9 7.6 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 CDW60615.1 - 0.074 13.0 0.1 2.7 7.9 0.1 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.21 CDW60615.1 - 0.094 12.0 1.2 0.18 11.1 0.1 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 CDW60615.1 - 0.11 12.1 2.5 0.2 11.3 0.1 2.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 CDW60615.1 - 0.14 11.5 0.4 1 8.6 0.0 2.6 3 1 1 4 4 4 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CDW60615.1 - 0.21 10.6 1.7 0.53 9.3 0.1 2.3 2 1 1 3 3 3 0 Lycopene cyclase protein F420_oxidored PF03807.17 CDW60615.1 - 0.34 11.5 4.0 5.4 7.7 0.2 3.1 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent WD40 PF00400.32 CDW60616.1 - 2.8e-10 40.6 12.5 0.017 15.9 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW60616.1 - 4e-08 33.5 0.1 1.2 9.5 0.0 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CDW60616.1 - 0.008 16.1 0.3 0.39 10.7 0.1 2.7 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 CDW60616.1 - 0.013 15.4 0.0 8.9 6.1 0.0 2.8 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CDW60616.1 - 0.023 13.7 0.3 0.39 9.6 0.0 2.8 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IQCJ-SCHIP1 PF15157.6 CDW60616.1 - 5.4 6.9 5.6 2.8 7.8 2.8 2.0 2 1 0 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif DDE_1 PF03184.19 CDW60617.1 - 0.041 13.5 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 DDE superfamily endonuclease DUF2757 PF10955.8 CDW60617.1 - 0.18 12.0 0.1 0.33 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) RAWUL PF16207.5 CDW60618.1 - 9.8e-09 35.8 0.0 2.1e-08 34.7 0.0 1.6 1 1 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C2H2 PF00096.26 CDW60619.1 - 0.0091 16.4 5.6 0.014 15.8 0.1 3.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW60619.1 - 0.062 14.2 0.2 0.062 14.2 0.2 3.6 4 0 0 4 4 4 0 C2H2-type zinc finger Zn_Tnp_IS1595 PF12760.7 CDW60619.1 - 0.064 13.2 1.5 0.13 12.3 0.3 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Arm PF00514.23 CDW60620.1 - 1.7e-05 24.7 0.0 1.7e-05 24.7 0.0 7.3 9 0 0 9 9 9 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 CDW60620.1 - 0.0014 18.2 0.3 0.016 14.6 0.1 2.6 3 0 0 3 3 3 1 Armadillo-like Cnd1 PF12717.7 CDW60620.1 - 0.0077 16.3 0.4 2 8.5 0.0 3.4 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 CDW60620.1 - 0.03 14.4 0.0 0.46 10.6 0.0 2.9 3 0 0 3 3 3 0 V-ATPase subunit H HEAT_EZ PF13513.6 CDW60620.1 - 0.34 11.5 4.7 12 6.5 0.0 4.8 6 0 0 6 6 6 0 HEAT-like repeat Amidase PF01425.21 CDW60621.1 - 4.3e-69 233.6 2.1 5.8e-69 233.2 2.1 1.1 1 0 0 1 1 1 1 Amidase Mito_carr PF00153.27 CDW60622.1 - 3.7e-68 225.5 2.6 2.2e-24 85.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Pkinase PF00069.25 CDW60623.1 - 2.8e-40 138.3 0.0 3.4e-40 138.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60623.1 - 1.4e-16 60.5 0.0 1.8e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CDW60623.1 - 0.00099 18.5 0.0 0.0013 18.1 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CDW60623.1 - 0.22 10.5 0.0 0.29 10.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain WD40 PF00400.32 CDW60624.1 - 1.6e-18 66.7 3.5 2.2e-07 31.4 0.1 6.1 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW60624.1 - 1.2e-09 38.3 0.0 0.046 14.0 0.0 4.4 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CDW60624.1 - 0.00021 21.3 0.0 0.05 13.5 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 CDW60624.1 - 0.008 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Ge1_WD40 PF16529.5 CDW60624.1 - 0.078 11.9 0.0 0.66 8.9 0.0 2.3 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Histone PF00125.24 CDW60625.1 - 1.8e-34 118.9 3.1 1.8e-34 118.9 3.1 1.7 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW60625.1 - 0.0001 22.4 0.1 0.00018 21.6 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold BRCT_assoc PF12820.7 CDW60625.1 - 0.02 14.7 1.0 0.026 14.3 1.0 1.2 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT CENP-S PF15630.6 CDW60625.1 - 0.033 14.6 0.0 0.055 13.9 0.0 1.4 1 0 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW60625.1 - 0.047 14.0 0.1 0.089 13.1 0.1 1.5 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW60625.1 - 0.12 12.6 0.2 0.22 11.7 0.2 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) Histone PF00125.24 CDW60626.1 - 5.5e-21 75.3 1.3 6.5e-21 75.1 0.6 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW60626.1 - 7e-06 26.2 2.7 1.5e-05 25.2 0.1 2.7 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW60626.1 - 0.0027 17.7 0.3 0.0048 16.9 0.1 1.5 2 0 0 2 2 2 1 YscO-like protein TFIID_20kDa PF03847.13 CDW60626.1 - 0.012 16.1 0.0 0.038 14.5 0.0 1.8 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A DUF1931 PF09123.11 CDW60626.1 - 0.065 13.3 0.0 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1931) Histone PF00125.24 CDW60627.1 - 1.3e-21 77.3 0.5 1.6e-21 77.0 0.5 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW60627.1 - 1.3e-06 28.6 1.0 3.7e-06 27.1 0.1 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW60627.1 - 0.001 19.1 0.3 0.0012 18.9 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 CDW60627.1 - 0.006 17.1 0.0 0.0098 16.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF1931 PF09123.11 CDW60627.1 - 0.05 13.7 0.0 0.074 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) 7TM_GPCR_Srsx PF10320.9 CDW60628.1 - 0.019 14.3 1.4 0.023 14.1 1.4 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx CLPTM1 PF05602.12 CDW60631.1 - 1e-63 215.9 0.4 1.3e-63 215.6 0.4 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) GyrB_insert PF18053.1 CDW60632.1 - 0.064 13.1 0.1 0.32 10.9 0.1 1.9 1 1 1 2 2 2 0 DNA gyrase B subunit insert domain Reprolysin PF01421.19 CDW60633.1 - 5.5e-22 78.6 0.2 9.1e-22 77.9 0.2 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 CDW60633.1 - 1.9e-10 41.2 14.1 1.9e-10 41.2 14.1 2.2 2 0 0 2 2 2 1 ADAM cysteine-rich EGF_2 PF07974.13 CDW60633.1 - 2.3e-06 27.8 7.7 2.3e-06 27.8 7.7 3.8 3 0 0 3 3 3 1 EGF-like domain I-EGF_1 PF18372.1 CDW60633.1 - 2.3 8.4 8.0 68 3.7 8.0 2.8 1 1 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 OstA PF03968.14 CDW60634.1 - 3.1e-13 49.9 0.0 4.2e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 OstA-like protein TerB PF05099.13 CDW60635.1 - 2.7e-10 40.4 0.8 5.7e-10 39.3 0.8 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TerB DnaJ PF00226.31 CDW60635.1 - 6.9e-08 32.5 0.0 1.3e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain HTH_10 PF04967.12 CDW60635.1 - 0.00037 20.2 0.0 0.032 14.1 0.0 2.6 2 0 0 2 2 2 1 HTH DNA binding domain DUF4311 PF14188.6 CDW60635.1 - 0.0031 17.3 0.7 0.0049 16.7 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4311) DUF3574 PF12098.8 CDW60635.1 - 0.069 12.9 0.0 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3574) RapA_C PF12137.8 CDW60636.1 - 9.7e-151 501.9 1.4 1.6e-150 501.1 1.4 1.3 1 0 0 1 1 1 1 RNA polymerase recycling family C-terminal Tudor_RapA PF18337.1 CDW60636.1 - 2.4e-28 98.1 0.0 6.5e-28 96.7 0.0 1.8 1 0 0 1 1 1 1 RapA N-terminal Tudor like domain Tudor_1_RapA PF18339.1 CDW60636.1 - 5.5e-24 83.8 0.0 1.3e-23 82.6 0.0 1.7 1 0 0 1 1 1 1 RapA N-terminal Tudor like domain 1 SNF2_N PF00176.23 CDW60636.1 - 7e-19 67.7 0.0 1.2e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CDW60636.1 - 5.5e-18 65.3 0.0 3.3e-16 59.6 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PseudoU_synth_2 PF00849.22 CDW60636.1 - 1.1e-17 64.5 0.0 1.1e-16 61.4 0.0 2.6 3 0 0 3 3 3 1 RNA pseudouridylate synthase ResIII PF04851.15 CDW60636.1 - 4.2e-10 39.9 0.0 1.3e-09 38.3 0.0 1.8 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CDW60636.1 - 2.7e-05 24.0 0.0 8.2e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.6 CDW60636.1 - 0.029 13.3 0.0 0.15 10.9 0.0 2.0 1 1 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 AAA_22 PF13401.6 CDW60636.1 - 0.14 12.5 0.5 0.86 9.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain DUF2482 PF10655.9 CDW60636.1 - 0.15 12.6 0.3 3.7 8.1 0.1 2.6 2 0 0 2 2 2 0 Hypothetical protein of unknown function (DUF2482) Flavi_DEAD PF07652.14 CDW60636.1 - 0.15 12.0 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain COG2 PF06148.11 CDW60636.1 - 0.16 12.0 4.4 1.1 9.4 1.7 2.8 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 FliT PF05400.13 CDW60636.1 - 4.3 8.2 10.8 12 6.8 0.2 4.2 4 0 0 4 4 4 0 Flagellar protein FliT DNA_pol_B PF00136.21 CDW60637.1 - 9.9e-44 149.8 0.0 1e-42 146.5 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase family B Aldolase_II PF00596.21 CDW60637.1 - 3.3e-33 115.2 0.4 5.2e-33 114.6 0.4 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DNA_pol_B_exo1 PF03104.19 CDW60637.1 - 4.5e-14 52.3 0.0 8e-07 28.5 0.0 2.3 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 CDW60637.1 - 8.3e-05 21.6 0.0 0.0059 15.5 0.0 2.1 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral Glyco_transf_4 PF13439.6 CDW60637.1 - 0.005 16.9 4.5 3.7 7.5 0.1 4.3 4 0 0 4 4 4 1 Glycosyltransferase Family 4 RNase_H_2 PF13482.6 CDW60637.1 - 0.083 12.9 0.0 0.42 10.6 0.0 2.2 1 1 0 1 1 1 0 RNase_H superfamily TraN PF06986.11 CDW60639.1 - 4.3e-80 268.9 23.7 4.3e-80 268.9 23.7 1.9 2 0 0 2 2 2 1 Type-1V conjugative transfer system mating pair stabilisation POTRA_2 PF08479.11 CDW60639.1 - 0.1 12.4 0.1 0.36 10.7 0.0 1.9 2 0 0 2 2 2 0 POTRA domain, ShlB-type TraU PF06834.11 CDW60640.1 - 1.6e-93 313.4 0.4 2.2e-93 312.9 0.4 1.1 1 0 0 1 1 1 1 TraU protein TrbC_Ftype PF09673.10 CDW60640.1 - 1.7e-19 69.9 0.0 4.3e-19 68.6 0.0 1.7 1 1 0 1 1 1 1 Type-F conjugative transfer system pilin assembly protein TraC_F_IV PF11130.8 CDW60641.1 - 6.5e-47 160.1 0.0 1.3e-46 159.2 0.0 1.5 1 0 0 1 1 1 1 F pilus assembly Type-IV secretion system for plasmid transfer TrbI_Ftype PF09677.10 CDW60641.1 - 8.9e-09 35.6 0.0 2.6e-08 34.1 0.0 1.8 1 0 0 1 1 1 1 Type-F conjugative transfer system protein (TrbI_Ftype) TraW_N PF12477.8 CDW60641.1 - 1.2e-08 34.6 0.2 2.5e-08 33.6 0.2 1.6 1 0 0 1 1 1 1 Sex factor F TraW protein N terminal AAA_10 PF12846.7 CDW60641.1 - 6.2e-05 22.1 0.0 0.0086 15.0 0.0 2.4 2 0 0 2 2 2 2 AAA-like domain DUF87 PF01935.17 CDW60641.1 - 7.1e-05 23.0 0.0 0.0002 21.5 0.0 1.7 2 0 0 2 2 2 1 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 CDW60641.1 - 0.00071 18.6 0.1 0.0076 15.2 0.0 2.1 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain T4SS-DNA_transf PF02534.14 CDW60641.1 - 0.021 13.6 0.0 2.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer Tti2 PF10521.9 CDW60641.1 - 0.15 11.5 0.2 0.3 10.6 0.2 1.4 1 0 0 1 1 1 0 Tti2 family FtsK_SpoIIIE PF01580.18 CDW60641.1 - 0.16 11.3 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family dsrm PF00035.26 CDW60644.1 - 0.0033 18.1 0.0 0.0044 17.7 0.0 1.2 1 0 0 1 1 1 1 Double-stranded RNA binding motif MacB_PCD PF12704.7 CDW60645.1 - 2.5e-41 142.2 3.3 2.5e-41 142.2 3.3 2.4 3 0 0 3 3 2 1 MacB-like periplasmic core domain ABC_tran PF00005.27 CDW60645.1 - 2.4e-31 109.1 0.0 4.3e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter FtsX PF02687.21 CDW60645.1 - 3.7e-11 43.3 11.9 1e-10 41.9 3.4 3.2 3 0 0 3 3 3 1 FtsX-like permease family SMC_N PF02463.19 CDW60645.1 - 3e-06 26.9 0.4 0.00023 20.6 0.4 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CDW60645.1 - 9.9e-05 22.3 1.5 0.057 13.2 0.3 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CDW60645.1 - 0.0012 18.6 0.7 0.0039 16.9 0.7 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW60645.1 - 0.0012 18.5 0.2 0.0029 17.3 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CDW60645.1 - 0.0014 18.9 0.6 0.013 15.8 0.6 2.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CDW60645.1 - 0.0029 17.5 0.1 0.0082 16.1 0.1 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 CDW60645.1 - 0.003 18.0 0.2 0.0067 16.8 0.2 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CDW60645.1 - 0.0042 17.3 0.0 0.013 15.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.7 CDW60645.1 - 0.0044 16.2 0.8 0.0044 16.2 0.8 1.4 2 0 0 2 2 2 1 ABC-2 family transporter protein MMR_HSR1 PF01926.23 CDW60645.1 - 0.0057 16.7 0.1 0.017 15.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF4396 PF14342.6 CDW60645.1 - 0.0097 16.3 0.9 0.0097 16.3 0.9 2.4 3 0 0 3 3 2 1 Domain of unknown function (DUF4396) AAA_28 PF13521.6 CDW60645.1 - 0.028 14.7 0.0 0.086 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CDW60645.1 - 0.05 14.1 0.0 0.089 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mlf1IP PF10248.9 CDW60645.1 - 0.069 13.1 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein DUF87 PF01935.17 CDW60645.1 - 0.11 12.5 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain Glyco_transf_4 PF13439.6 CDW60645.1 - 0.11 12.4 0.1 0.3 11.1 0.1 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 NB-ARC PF00931.22 CDW60645.1 - 0.15 11.2 0.1 1.5 8.0 0.2 2.2 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 CDW60645.1 - 0.16 11.7 0.1 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF4064 PF13273.6 CDW60645.1 - 0.55 10.5 17.5 0.16 12.2 7.2 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF4064) CSD PF00313.22 CDW60646.1 - 6.3e-29 99.6 0.2 7.1e-29 99.5 0.2 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 CDW60646.1 - 0.00086 18.9 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 Ribonuclease B OB domain Amidase_6 PF12671.7 CDW60646.1 - 0.082 13.0 0.0 0.084 13.0 0.0 1.0 1 0 0 1 1 1 0 Putative amidase domain ClpS PF02617.17 CDW60647.1 - 6.6e-34 115.6 0.1 8.1e-34 115.3 0.1 1.1 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS AAA_2 PF07724.14 CDW60648.1 - 2.8e-51 174.0 0.0 1.5e-47 161.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CDW60648.1 - 5.1e-30 103.5 2.7 7.9e-30 102.9 1.4 2.0 2 0 0 2 2 1 1 AAA lid domain ClpB_D2-small PF10431.9 CDW60648.1 - 2.4e-25 88.4 0.0 6.9e-25 86.9 0.0 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CDW60648.1 - 3.7e-24 85.6 0.1 7.7e-13 49.0 0.0 3.2 2 1 1 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW60648.1 - 4.4e-19 68.9 0.0 2.9e-13 50.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 CDW60648.1 - 1.9e-16 59.9 1.3 8e-15 54.7 1.2 2.9 2 0 0 2 2 2 1 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 CDW60648.1 - 1.6e-12 47.5 0.2 5.2e-05 23.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 CDW60648.1 - 1.1e-11 45.4 6.6 1.7e-06 28.6 0.2 4.0 4 1 0 4 4 3 2 AAA ATPase domain TniB PF05621.11 CDW60648.1 - 1.2e-10 41.1 0.1 1.3e-07 31.2 0.0 3.6 2 2 1 3 3 3 1 Bacterial TniB protein AAA_22 PF13401.6 CDW60648.1 - 3.1e-07 30.7 2.5 0.027 14.7 0.0 4.1 2 2 0 2 2 2 2 AAA domain ResIII PF04851.15 CDW60648.1 - 2.1e-06 27.9 0.0 0.049 13.6 0.0 3.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TIP49 PF06068.13 CDW60648.1 - 8.7e-06 25.2 0.1 0.14 11.3 0.0 2.7 2 1 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 CDW60648.1 - 1.5e-05 24.8 6.0 0.14 11.9 0.3 4.6 3 2 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CDW60648.1 - 1.9e-05 24.7 0.0 0.015 15.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CDW60648.1 - 3e-05 23.6 0.0 0.22 11.0 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 CDW60648.1 - 4.3e-05 24.1 0.2 0.035 14.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 CDW60648.1 - 9.8e-05 22.2 0.0 0.074 12.8 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CDW60648.1 - 0.00027 20.4 3.3 5.5 6.3 0.1 4.3 3 2 2 5 5 5 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CDW60648.1 - 0.00027 20.8 0.1 0.0038 17.1 0.1 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDW60648.1 - 0.00042 20.0 0.1 0.43 10.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_6 PF12774.7 CDW60648.1 - 0.00044 19.3 0.0 0.0011 18.0 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_33 PF13671.6 CDW60648.1 - 0.00085 19.5 0.0 0.32 11.2 0.0 3.1 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 CDW60648.1 - 0.0018 18.2 0.1 1.2 9.2 0.1 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 CDW60648.1 - 0.0033 17.4 0.0 1.2 9.0 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 CDW60648.1 - 0.0052 17.2 0.0 4.5 7.7 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA_29 PF13555.6 CDW60648.1 - 0.011 15.4 0.0 3.1 7.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 CDW60648.1 - 0.023 14.6 0.0 0.62 10.0 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_23 PF13476.6 CDW60648.1 - 0.036 14.6 2.6 2.6 8.5 0.2 3.5 2 1 1 3 3 3 0 AAA domain NACHT PF05729.12 CDW60648.1 - 0.036 14.0 0.1 0.28 11.1 0.0 2.4 2 0 0 2 2 2 0 NACHT domain CbiA PF01656.23 CDW60648.1 - 0.039 14.0 0.1 11 6.1 0.0 2.7 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DNA_pol3_delta2 PF13177.6 CDW60648.1 - 0.063 13.1 0.2 6.3 6.5 0.0 3.6 4 0 0 4 4 4 0 DNA polymerase III, delta subunit CHAD PF05235.14 CDW60648.1 - 0.064 13.2 0.1 0.18 11.8 0.0 1.9 2 0 0 2 2 1 0 CHAD domain IPT PF01745.16 CDW60648.1 - 0.11 11.8 0.0 0.41 10.0 0.0 1.9 2 0 0 2 2 2 0 Isopentenyl transferase ATPase_2 PF01637.18 CDW60648.1 - 0.4 10.6 3.4 5.3 6.9 0.1 3.3 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea eIF-1a PF01176.19 CDW60649.1 - 8e-28 96.0 0.0 8.9e-28 95.9 0.0 1.0 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RsgA_N PF16745.5 CDW60649.1 - 3e-05 23.7 0.0 3.7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 RsgA N-terminal domain RNase_II_C_S1 PF18614.1 CDW60649.1 - 0.016 15.1 0.0 0.035 14.1 0.0 1.8 1 1 0 1 1 1 0 RNase II-type exonuclease C-terminal S1 domain S1 PF00575.23 CDW60649.1 - 0.027 14.8 0.1 0.033 14.5 0.1 1.2 1 0 0 1 1 1 0 S1 RNA binding domain Myosin_N PF02736.19 CDW60649.1 - 0.053 13.4 0.0 5.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain CSD2 PF17876.1 CDW60649.1 - 0.1 12.8 0.1 5 7.4 0.0 2.6 1 1 2 3 3 3 0 Cold shock domain Leu_Phe_trans PF03588.14 CDW60650.1 - 2e-70 235.7 0.0 2.3e-70 235.5 0.0 1.0 1 0 0 1 1 1 1 Leucyl/phenylalanyl-tRNA protein transferase Acetyltransf_6 PF13480.7 CDW60650.1 - 0.024 14.8 0.3 0.16 12.1 0.3 2.1 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain ABC_tran PF00005.27 CDW60651.1 - 3.8e-35 121.4 0.0 6e-35 120.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW60651.1 - 3.5e-09 36.9 0.6 0.0002 21.3 0.3 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW60651.1 - 5.5e-07 29.2 0.1 9e-05 22.0 0.0 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDW60651.1 - 2.8e-06 27.7 0.2 2e-05 24.9 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW60651.1 - 1.5e-05 25.4 1.4 2.4e-05 24.8 1.4 1.3 1 0 0 1 1 1 1 AAA ATPase domain DUF87 PF01935.17 CDW60651.1 - 4.8e-05 23.6 0.0 9.1e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain NACHT PF05729.12 CDW60651.1 - 6.3e-05 22.9 0.7 0.0042 17.0 0.0 2.3 2 1 0 2 2 2 1 NACHT domain FtsK_SpoIIIE PF01580.18 CDW60651.1 - 0.0012 18.2 0.2 0.014 14.8 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 CDW60651.1 - 0.0019 18.3 0.0 0.0029 17.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CDW60651.1 - 0.0033 17.3 0.1 0.0073 16.2 0.0 1.5 2 0 0 2 2 1 1 RsgA GTPase AAA_30 PF13604.6 CDW60651.1 - 0.0063 16.2 0.0 0.0092 15.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW60651.1 - 0.0087 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 CDW60651.1 - 0.016 15.2 0.1 0.15 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CDW60651.1 - 0.017 14.8 0.2 1.1 8.9 0.0 2.4 3 0 0 3 3 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 CDW60651.1 - 0.018 15.5 0.1 0.033 14.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CDW60651.1 - 0.019 14.9 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 CDW60651.1 - 0.041 13.3 0.1 0.08 12.3 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 CDW60651.1 - 0.052 12.6 0.1 0.092 11.8 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 CDW60651.1 - 0.059 12.3 0.0 0.088 11.7 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_7 PF12775.7 CDW60651.1 - 0.063 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CDW60651.1 - 0.094 13.1 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 CDW60651.1 - 0.095 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.22 CDW60651.1 - 0.11 11.6 0.1 0.27 10.4 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 CDW60651.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CDW60651.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 CDW60651.1 - 0.14 11.7 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CDW60651.1 - 0.15 12.6 0.0 0.33 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Histone PF00125.24 CDW60652.1 - 2.5e-35 121.7 1.6 2.5e-35 121.7 1.6 1.6 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW60652.1 - 9.9e-05 22.4 0.1 0.00016 21.7 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold BRCT_assoc PF12820.7 CDW60652.1 - 0.028 14.2 1.0 0.037 13.8 1.0 1.3 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT CENP-S PF15630.6 CDW60652.1 - 0.034 14.5 0.0 0.054 13.9 0.0 1.4 1 0 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW60652.1 - 0.076 13.3 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CDW60652.1 - 0.097 12.9 0.2 0.18 12.0 0.2 1.4 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) Trypsin PF00089.26 CDW60653.1 - 3e-09 37.0 0.0 4.5e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Trypsin PAP_assoc PF03828.19 CDW60654.1 - 1.3e-05 25.3 0.2 5.9e-05 23.2 0.3 2.1 2 1 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDW60654.1 - 0.042 14.1 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain Guanylate_kin PF00625.21 CDW60655.1 - 1e-62 211.1 0.0 1.2e-62 210.9 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 CDW60655.1 - 1.7e-08 34.7 0.0 8.5e-08 32.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CDW60655.1 - 5.8e-08 33.3 0.1 1.3e-07 32.2 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 CDW60655.1 - 7.4e-05 23.3 0.0 8.6e-05 23.1 0.0 1.3 1 1 0 1 1 1 1 ABC transporter Rad17 PF03215.15 CDW60655.1 - 0.00013 21.9 0.0 0.00032 20.7 0.0 1.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 CDW60655.1 - 0.00024 21.4 0.2 0.00045 20.5 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CDW60655.1 - 0.00029 21.4 0.2 0.0013 19.3 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CDW60655.1 - 0.00045 19.8 0.0 0.00075 19.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 CDW60655.1 - 0.0011 19.0 0.0 0.0041 17.2 0.0 1.9 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 CDW60655.1 - 0.0017 18.3 0.0 0.0046 16.9 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_28 PF13521.6 CDW60655.1 - 0.0019 18.5 0.0 0.015 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CDW60655.1 - 0.0019 18.2 0.0 0.0049 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 CDW60655.1 - 0.0023 17.9 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase RNA_helicase PF00910.22 CDW60655.1 - 0.005 17.2 0.0 0.0098 16.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Viral_helicase1 PF01443.18 CDW60655.1 - 0.007 16.1 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 CDW60655.1 - 0.0075 16.2 0.0 0.022 14.7 0.0 1.7 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_17 PF13207.6 CDW60655.1 - 0.0077 16.7 0.2 0.12 12.7 0.0 2.3 2 1 1 3 3 3 1 AAA domain NTPase_1 PF03266.15 CDW60655.1 - 0.0088 16.0 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 NTPase AAA PF00004.29 CDW60655.1 - 0.0089 16.5 0.2 0.03 14.8 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CDW60655.1 - 0.01 15.9 0.0 0.026 14.6 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CDW60655.1 - 0.023 14.4 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CDW60655.1 - 0.024 13.9 0.1 0.15 11.3 0.0 2.2 2 1 1 3 3 3 0 Zeta toxin AAA_23 PF13476.6 CDW60655.1 - 0.042 14.4 0.2 0.21 12.1 0.0 1.9 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 CDW60655.1 - 0.049 13.2 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain dNK PF01712.19 CDW60655.1 - 0.054 13.3 0.0 1.7 8.5 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase PduV-EutP PF10662.9 CDW60655.1 - 0.054 13.2 0.1 0.32 10.7 0.1 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation T2SSE PF00437.20 CDW60655.1 - 0.063 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Roc PF08477.13 CDW60655.1 - 0.19 12.0 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ribosomal_L6e PF01159.19 CDW60656.1 - 1.7e-36 125.1 0.3 4.8e-35 120.5 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 CDW60656.1 - 4.7e-06 26.7 9.4 4.7e-06 26.7 9.4 2.8 2 1 0 2 2 2 1 Ribosomal protein L6, N-terminal domain IL13 PF03487.13 CDW60657.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Interleukin-13 AAA PF00004.29 CDW60659.1 - 2.8e-97 322.2 0.0 1.6e-47 161.3 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CDW60659.1 - 4.8e-25 87.1 0.8 4e-11 42.5 0.0 2.9 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 CDW60659.1 - 1.4e-17 63.6 3.6 2.5e-17 62.8 2.2 2.1 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 CDW60659.1 - 2.1e-14 53.6 0.0 3e-06 27.1 0.0 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CDW60659.1 - 2e-13 51.1 0.4 0.00014 22.3 0.0 4.4 3 2 1 4 4 3 2 AAA ATPase domain AAA_5 PF07728.14 CDW60659.1 - 7.6e-11 42.2 0.2 0.00014 21.9 0.0 3.7 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CDW60659.1 - 1.8e-10 41.2 0.0 4.4e-05 23.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CDW60659.1 - 2.7e-10 40.6 0.0 0.00017 21.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 CDW60659.1 - 3.7e-09 36.2 0.0 1e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 CDW60659.1 - 4.3e-09 36.7 0.3 0.032 14.5 0.1 4.4 3 2 1 4 4 3 2 AAA domain TIP49 PF06068.13 CDW60659.1 - 1.4e-08 34.3 0.0 0.0065 15.7 0.0 3.4 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_14 PF13173.6 CDW60659.1 - 7.9e-08 32.4 0.0 0.0052 16.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CDW60659.1 - 8e-08 32.6 0.0 0.0073 16.7 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 CDW60659.1 - 9.5e-08 32.7 0.0 0.013 16.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 CDW60659.1 - 3.4e-07 29.9 0.2 0.024 14.0 0.0 2.6 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI Vps4_C PF09336.10 CDW60659.1 - 4.5e-07 29.8 0.4 0.00012 22.0 0.0 2.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 CDW60659.1 - 7.9e-07 29.0 0.0 0.032 14.0 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.27 CDW60659.1 - 8.3e-07 29.6 0.0 0.008 16.7 0.0 3.5 2 1 0 2 2 2 2 ABC transporter NACHT PF05729.12 CDW60659.1 - 1.8e-06 27.9 0.1 0.16 11.9 0.0 3.7 3 1 1 4 4 4 2 NACHT domain ATPase_2 PF01637.18 CDW60659.1 - 2.6e-06 27.5 0.9 0.23 11.4 0.0 4.1 4 1 0 4 4 3 2 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 CDW60659.1 - 4.2e-06 26.0 0.0 0.018 14.2 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 CDW60659.1 - 6.2e-06 25.9 0.0 0.17 11.4 0.0 3.4 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 CDW60659.1 - 7e-06 26.0 0.0 0.011 15.5 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 CDW60659.1 - 1e-05 25.0 0.0 1.3 8.3 0.0 3.5 3 0 0 3 3 3 2 KaiC AAA_28 PF13521.6 CDW60659.1 - 1.2e-05 25.7 0.0 0.25 11.6 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 CDW60659.1 - 1.3e-05 25.6 0.5 0.51 10.8 0.0 3.9 4 1 0 4 4 3 2 AAA domain Bac_DnaA PF00308.18 CDW60659.1 - 2.5e-05 24.3 0.0 0.078 12.8 0.0 2.6 2 0 0 2 2 2 2 Bacterial dnaA protein Sigma54_activat PF00158.26 CDW60659.1 - 5.7e-05 22.9 0.0 0.6 9.8 0.0 3.3 2 1 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 CDW60659.1 - 5.9e-05 23.1 0.0 0.28 11.2 0.0 2.7 2 1 1 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 CDW60659.1 - 6.2e-05 23.0 0.0 0.4 10.6 0.0 2.6 2 1 0 2 2 2 2 Rad17 P-loop domain AAA_24 PF13479.6 CDW60659.1 - 7.9e-05 22.5 0.0 0.25 11.1 0.0 3.1 2 1 0 2 2 2 2 AAA domain NB-ARC PF00931.22 CDW60659.1 - 8.7e-05 21.8 0.0 0.34 10.1 0.0 2.8 3 0 0 3 3 3 2 NB-ARC domain AAA_7 PF12775.7 CDW60659.1 - 0.00011 21.7 0.0 0.2 11.1 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 CDW60659.1 - 0.00011 22.3 0.0 0.47 10.6 0.0 2.9 2 0 0 2 2 2 2 Sigma-54 interaction domain DUF815 PF05673.13 CDW60659.1 - 0.00014 21.1 0.0 0.052 12.7 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 CDW60659.1 - 0.00022 20.5 0.0 0.95 8.7 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin AAA_3 PF07726.11 CDW60659.1 - 0.0014 18.5 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 CDW60659.1 - 0.0026 17.2 0.0 1.6 8.2 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein Cytidylate_kin2 PF13189.6 CDW60659.1 - 0.0065 16.6 0.0 0.65 10.1 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family UFD1 PF03152.14 CDW60659.1 - 0.0071 15.8 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AAA_11 PF13086.6 CDW60659.1 - 0.0085 15.9 0.1 5.1 6.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 CDW60659.1 - 0.013 15.9 0.1 11 6.3 0.1 2.9 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CDW60659.1 - 0.015 14.6 0.0 5.7 6.1 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) SKI PF01202.22 CDW60659.1 - 0.023 14.8 0.1 11 6.1 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase NTPase_1 PF03266.15 CDW60659.1 - 0.043 13.7 0.1 9 6.2 0.0 3.5 3 0 0 3 3 3 0 NTPase TniB PF05621.11 CDW60659.1 - 0.054 12.9 0.0 12 5.3 0.0 3.4 4 0 0 4 4 3 0 Bacterial TniB protein AAA_23 PF13476.6 CDW60659.1 - 0.093 13.2 0.5 17 5.9 0.0 3.0 3 0 0 3 3 2 0 AAA domain PduV-EutP PF10662.9 CDW60659.1 - 0.097 12.4 0.0 9.9 5.9 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Molydop_binding PF01568.21 CDW60659.1 - 0.1 12.6 0.4 0.25 11.4 0.1 1.8 2 0 0 2 2 1 0 Molydopterin dinucleotide binding domain Adeno_IVa2 PF02456.15 CDW60659.1 - 0.12 11.2 0.0 3.6 6.3 0.0 2.1 2 0 0 2 2 2 0 Adenovirus IVa2 protein DUF4251 PF14059.6 CDW60659.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) zf-H2C2_2 PF13465.6 CDW60660.1 - 7.8e-25 86.1 32.7 1.2e-08 35.0 1.7 5.8 6 0 0 6 6 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 CDW60660.1 - 1.2e-23 82.1 29.7 1.4e-06 28.4 2.5 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW60660.1 - 2.7e-18 65.1 28.2 0.00016 22.2 1.3 5.3 5 0 0 5 5 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CDW60660.1 - 2.8e-07 30.4 25.2 0.0065 16.4 0.4 5.0 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CDW60660.1 - 1e-06 28.8 12.8 0.054 13.8 0.3 4.6 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 CDW60660.1 - 1.9e-06 28.0 11.7 0.00071 19.8 3.1 2.9 1 1 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 CDW60660.1 - 8.2e-06 25.5 2.8 0.018 14.8 0.3 2.5 1 1 0 2 2 2 2 GAGA factor zf-C2H2_11 PF16622.5 CDW60660.1 - 1.3e-05 24.8 19.2 0.00019 21.1 1.1 4.5 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 CDW60660.1 - 0.00034 20.4 2.6 0.12 12.3 0.1 3.6 2 1 1 3 3 3 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 CDW60660.1 - 0.01 16.1 16.4 5.8 7.3 8.2 4.6 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Zn_ribbon_SprT PF17283.2 CDW60660.1 - 0.042 13.8 12.9 0.082 12.8 1.5 3.7 2 1 1 3 3 3 0 SprT-like zinc ribbon domain BolA PF01722.18 CDW60660.1 - 0.085 13.1 2.7 13 6.2 0.1 3.3 2 1 0 3 3 3 0 BolA-like protein zf-C2H2_3rep PF18868.1 CDW60660.1 - 0.12 13.1 6.2 11 6.7 5.4 3.3 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats C1_1 PF00130.22 CDW60660.1 - 0.13 12.2 9.9 2.8 7.9 0.9 2.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-C2H2_12 PF18112.1 CDW60660.1 - 0.35 11.4 2.1 22 5.6 0.1 3.7 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-met PF12874.7 CDW60660.1 - 0.52 10.8 25.0 0.56 10.7 1.8 5.1 5 0 0 5 5 4 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 CDW60660.1 - 0.57 9.8 6.6 3.1 7.5 0.1 3.9 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-MYST PF17772.1 CDW60660.1 - 0.74 9.5 7.0 4.1 7.1 0.4 3.9 3 1 1 4 4 4 0 MYST family zinc finger domain zf-C2HE PF16278.5 CDW60660.1 - 0.75 10.3 16.9 1.1 9.7 0.3 3.9 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF3268 PF11672.8 CDW60660.1 - 0.88 9.9 5.4 14 6.1 0.1 2.8 3 0 0 3 3 3 0 zinc-finger-containing domain zf-AN1 PF01428.16 CDW60660.1 - 1.3 9.3 10.9 24 5.2 0.1 4.9 4 0 0 4 4 4 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 CDW60660.1 - 1.8 8.7 10.3 1 9.5 1.1 3.5 2 1 1 3 3 3 0 Zinc ribbon domain TRAF6_Z2 PF18048.1 CDW60660.1 - 2.2 8.4 9.0 5.3 7.2 0.1 3.6 4 0 0 4 4 3 0 TNF receptor-associated factor 6 zinc finger 2 zinc_ribbon_15 PF17032.5 CDW60660.1 - 2.3 9.0 12.4 2.2 9.1 1.7 3.2 2 1 1 3 3 3 0 zinc-ribbon family DUF2256 PF10013.9 CDW60660.1 - 3.1 8.0 7.7 15 5.8 0.1 3.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf_C2H2_ZHX PF18387.1 CDW60660.1 - 6.1 6.6 11.7 1.1 8.9 0.5 3.8 1 1 3 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 CDW60660.1 - 6.1 6.9 19.1 0.074 13.1 1.6 3.7 1 1 2 3 3 3 0 BED zinc finger zf-LYAR PF08790.11 CDW60660.1 - 6.5 6.7 12.7 1.1 9.3 0.1 4.1 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger LIM PF00412.22 CDW60660.1 - 7.2 6.9 9.5 6.6 7.0 3.8 2.9 1 1 1 2 2 2 0 LIM domain Elf1 PF05129.13 CDW60660.1 - 8.7 6.5 11.0 3.9 7.6 2.9 2.9 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like VEFS-Box PF09733.9 CDW60661.1 - 0.026 14.4 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 VEFS-Box of polycomb protein GSHPx PF00255.19 CDW60662.1 - 6e-42 141.6 4.8 2e-26 91.7 0.5 4.3 2 2 0 2 2 2 2 Glutathione peroxidase DUF807 PF05660.11 CDW60662.1 - 0.088 12.8 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 Coxiella burnetii protein of unknown function (DUF807) PixA PF12306.8 CDW60662.1 - 0.17 12.1 1.1 0.68 10.1 0.1 2.3 3 0 0 3 3 3 0 Inclusion body protein DUF3895 PF13034.6 CDW60662.1 - 0.68 10.0 3.3 4.7 7.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3895) WAP PF00095.21 CDW60663.1 - 2.6e-16 59.7 31.7 2.9e-08 34.0 7.1 3.4 3 0 0 3 3 3 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' Dickkopf_N PF04706.12 CDW60663.1 - 5.1 7.6 22.5 4.4 7.9 13.6 2.9 2 1 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region Integrase_H2C2 PF17921.1 CDW60664.1 - 0.0001 22.3 0.0 0.00017 21.6 0.0 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain Peptidase_M14 PF00246.24 CDW60666.1 - 4.3e-31 108.8 0.0 5.5e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 CDW60666.1 - 1.5e-05 25.3 0.0 2.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Histone PF00125.24 CDW60667.1 - 1.2e-15 58.0 0.7 1.5e-15 57.7 0.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW60667.1 - 4e-06 27.0 0.0 6.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 CDW60667.1 - 0.012 15.8 0.1 0.017 15.3 0.1 1.1 1 0 0 1 1 1 0 CENP-W protein TAF PF02969.17 CDW60667.1 - 0.037 14.2 0.1 0.069 13.3 0.1 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) TFIID_20kDa PF03847.13 CDW60667.1 - 0.041 14.4 0.0 0.068 13.7 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A DUF4262 PF14081.6 CDW60667.1 - 0.19 12.0 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4262) MCPsignal PF00015.21 CDW60668.1 - 2.3e-46 157.8 29.7 6.6e-46 156.3 16.7 2.5 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain PAS_3 PF08447.12 CDW60668.1 - 3.8e-17 62.4 0.0 7.9e-17 61.3 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CDW60668.1 - 1.7e-08 34.7 0.0 6e-08 32.9 0.0 2.0 2 0 0 2 2 1 1 PAS domain PAS PF00989.25 CDW60668.1 - 4.8e-07 29.8 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold HAMP PF00672.25 CDW60668.1 - 2.5e-05 24.6 1.1 0.00046 20.5 0.0 3.4 4 0 0 4 4 3 1 HAMP domain PAS_4 PF08448.10 CDW60668.1 - 0.0025 18.0 0.0 0.0083 16.4 0.0 1.9 1 0 0 1 1 1 1 PAS fold Mur_ligase_C PF02875.21 CDW60668.1 - 0.0046 17.2 0.6 0.019 15.2 0.1 2.3 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain TMP_2 PF06791.13 CDW60668.1 - 0.016 14.8 10.0 0.016 14.8 10.0 2.4 1 1 0 2 2 2 0 Prophage tail length tape measure protein PAS_8 PF13188.7 CDW60668.1 - 0.15 12.2 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 PAS domain DUF948 PF06103.11 CDW60668.1 - 0.17 12.2 26.3 0.054 13.8 4.8 4.6 3 2 1 4 4 3 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.15 CDW60668.1 - 0.2 11.5 4.7 3.5 7.5 0.2 2.5 2 0 0 2 2 2 0 Sec34-like family DUF4131 PF13567.6 CDW60668.1 - 0.25 11.0 4.8 0.37 10.4 3.7 1.9 2 1 0 2 2 1 0 Domain of unknown function (DUF4131) Goodbye PF17109.5 CDW60668.1 - 0.3 11.5 7.8 0.41 11.1 0.2 3.1 3 1 0 3 3 3 0 fungal STAND N-terminal Goodbye domain Noelin-1 PF12308.8 CDW60668.1 - 0.5 10.4 7.1 1.8 8.6 0.6 3.2 3 1 0 3 3 2 0 Neurogenesis glycoprotein UbiA PF01040.18 CDW60668.1 - 0.52 9.6 7.0 0.64 9.3 5.5 1.7 2 0 0 2 2 2 0 UbiA prenyltransferase family Pro-NT_NN PF07421.11 CDW60668.1 - 0.55 10.5 3.2 2.6 8.3 0.4 2.3 2 0 0 2 2 2 0 Neurotensin/neuromedin N precursor Acyl-CoA_dh_C PF12806.7 CDW60668.1 - 0.91 9.7 6.0 0.72 10.0 0.3 3.1 2 1 0 2 2 2 0 Acetyl-CoA dehydrogenase C-terminal like DUF2497 PF10691.9 CDW60668.1 - 1.1 9.7 4.7 1.3 9.5 0.2 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2497) CdvA PF18822.1 CDW60668.1 - 2.5 7.9 5.0 18 5.2 0.2 3.2 3 1 0 3 3 3 0 CdvA-like coiled-coil domain DUF3450 PF11932.8 CDW60668.1 - 4.7 6.4 16.2 2 7.7 4.5 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin_2 PF14523.6 CDW60668.1 - 6.2 7.2 12.3 2.4 8.6 3.5 3.1 1 1 2 3 3 3 0 Syntaxin-like protein Aminotran_3 PF00202.21 CDW60669.1 - 2.4e-103 345.9 0.0 3.4e-103 345.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III tRNA_bind PF01588.20 CDW60670.1 - 3.3e-31 107.2 0.4 3.7e-31 107.1 0.4 1.0 1 0 0 1 1 1 1 Putative tRNA binding domain Peripla_BP_3 PF13377.6 CDW60671.1 - 3e-31 109.0 0.0 1.3e-30 106.9 0.0 1.9 2 0 0 2 2 2 1 Periplasmic binding protein-like domain LacI PF00356.21 CDW60671.1 - 6.1e-18 64.3 0.1 1.1e-17 63.5 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family Peripla_BP_1 PF00532.21 CDW60671.1 - 1.3e-07 31.3 0.0 1.2e-06 28.2 0.0 1.9 1 1 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family HTH_7 PF02796.15 CDW60671.1 - 0.046 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase LMWPc PF01451.21 CDW60671.1 - 0.064 13.6 0.0 0.17 12.2 0.0 1.8 1 1 0 1 1 1 0 Low molecular weight phosphotyrosine protein phosphatase HTH_23 PF13384.6 CDW60671.1 - 0.13 12.1 0.0 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain HTH_IclR PF09339.10 CDW60671.1 - 0.14 12.0 0.1 3.1 7.7 0.0 2.5 2 0 0 2 2 2 0 IclR helix-turn-helix domain Glyco_hydro_2_C PF02836.17 CDW60672.1 - 2.2e-120 401.4 2.9 3.4e-120 400.7 2.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Bgal_small_N PF02929.17 CDW60672.1 - 3e-56 190.7 0.1 6.6e-56 189.6 0.0 1.6 2 0 0 2 2 2 1 Beta galactosidase small chain Glyco_hydro_2_N PF02837.18 CDW60672.1 - 2.3e-47 161.0 0.8 1.3e-46 158.6 0.3 2.2 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 CDW60672.1 - 4.8e-19 69.0 0.0 1.9e-18 67.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 DUF4981 PF16353.5 CDW60672.1 - 4.4e-17 62.3 0.2 1.3e-16 60.8 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function(DUF4981) Glyco_hydro_72 PF03198.14 CDW60672.1 - 0.075 12.3 0.1 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 Glucanosyltransferase Histone PF00125.24 CDW60673.1 - 3.2e-17 63.1 1.2 4.1e-17 62.8 1.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW60673.1 - 0.0028 17.9 0.0 0.0028 17.9 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CDW60673.1 - 0.024 15.1 0.1 0.045 14.3 0.1 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone_H2A_C PF16211.5 CDW60674.1 - 1.1e-17 63.5 0.4 1.5e-17 63.0 0.4 1.2 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CDW60674.1 - 4.3e-10 40.0 0.0 5.8e-10 39.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW60674.1 - 0.017 15.4 0.0 0.023 14.9 0.0 1.2 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Peptidase_C69 PF03577.15 CDW60675.1 - 2.1e-07 30.2 0.0 2.9e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 zf-CDGSH PF09360.10 CDW60676.1 - 4.9e-20 71.5 5.1 3.9e-10 39.8 0.2 2.4 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type Thioredoxin PF00085.20 CDW60677.1 - 3.6e-66 219.6 3.3 8.5e-34 115.7 0.1 4.0 4 0 0 4 4 4 3 Thioredoxin Thioredoxin_6 PF13848.6 CDW60677.1 - 1.2e-48 165.5 8.9 1.3e-40 139.3 5.1 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CDW60677.1 - 2.2e-13 50.6 2.0 9.7e-06 26.0 0.0 4.0 3 1 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 CDW60677.1 - 6.1e-13 48.8 0.4 0.00039 19.9 0.0 3.2 2 1 1 3 3 3 3 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CDW60677.1 - 2.9e-11 43.4 0.1 0.0029 17.7 0.0 3.9 3 0 0 3 3 3 2 Thioredoxin-like Calsequestrin PF01216.17 CDW60677.1 - 8.5e-11 41.5 6.4 1.4e-10 40.8 6.4 1.3 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_8 PF13905.6 CDW60677.1 - 1e-10 41.8 0.3 0.018 15.4 0.0 4.9 3 2 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 CDW60677.1 - 1.6e-10 41.0 1.8 0.0099 15.8 0.0 4.4 3 2 1 4 4 4 2 AhpC/TSA family Redoxin PF08534.10 CDW60677.1 - 3.6e-05 23.5 0.2 0.53 10.0 0.0 3.0 3 0 0 3 3 3 2 Redoxin HyaE PF07449.11 CDW60677.1 - 0.00058 19.8 0.0 0.56 10.2 0.0 3.2 3 1 0 3 3 3 2 Hydrogenase-1 expression protein HyaE TraF PF13728.6 CDW60677.1 - 0.001 19.0 0.0 0.18 11.6 0.0 2.7 3 0 0 3 3 3 1 F plasmid transfer operon protein Glutaredoxin PF00462.24 CDW60677.1 - 0.0015 18.7 3.9 0.35 11.1 0.0 4.3 4 1 0 4 4 4 1 Glutaredoxin rve PF00665.26 CDW60678.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Integrase core domain Integrase_H2C2 PF17921.1 CDW60679.1 - 0.0074 16.4 0.1 0.012 15.7 0.1 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-C2H2_10 PF16588.5 CDW60680.1 - 0.0049 16.6 5.1 0.0049 16.6 5.1 3.9 3 1 0 3 3 3 1 C2H2 zinc-finger Collagen PF01391.18 CDW60682.1 - 2.9e-23 81.4 91.6 0.00012 21.8 18.0 4.3 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 CDW60682.1 - 5e-21 74.5 1.0 8.2e-21 73.8 1.0 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain CTP_transf_like PF01467.26 CDW60686.1 - 5.7e-29 101.2 0.0 8.1e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like SSF PF00474.17 CDW60687.1 - 5.2e-142 473.5 29.8 6.7e-142 473.1 29.8 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family PrmA PF06325.13 CDW60687.1 - 9.2e-104 347.0 0.0 1.3e-103 346.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Dus PF01207.17 CDW60687.1 - 1e-15 57.7 0.0 1.6e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) MTS PF05175.14 CDW60687.1 - 7.6e-10 38.6 0.0 1.4e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDW60687.1 - 1.6e-09 37.7 0.0 2.7e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW60687.1 - 6.8e-08 33.1 0.0 1.4e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW60687.1 - 1.7e-05 25.5 0.1 5.5e-05 23.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CDW60687.1 - 1.9e-05 24.5 0.0 3.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW60687.1 - 7.8e-05 22.6 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW60687.1 - 7.8e-05 23.2 0.0 0.00016 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CDW60687.1 - 0.00024 20.8 0.0 0.00054 19.7 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical protein 95 N6_N4_Mtase PF01555.18 CDW60687.1 - 0.00042 20.1 0.0 0.00062 19.5 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Met_10 PF02475.16 CDW60687.1 - 0.00085 19.1 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.6 CDW60687.1 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CDW60687.1 - 0.0032 17.3 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 CDW60687.1 - 0.0087 15.8 0.3 0.024 14.3 0.3 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_9 PF08003.11 CDW60687.1 - 0.012 14.5 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CMAS PF02353.20 CDW60687.1 - 0.028 13.7 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_15 PF09445.10 CDW60687.1 - 0.031 13.8 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase CPSase_L_D2 PF02786.17 CDW60688.1 - 1.5e-86 289.3 0.0 2.3e-86 288.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CDW60688.1 - 2.6e-44 150.2 0.1 5.6e-44 149.2 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CDW60688.1 - 3.5e-38 130.0 0.0 6.9e-38 129.1 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_3 PF02655.14 CDW60688.1 - 1.3e-07 31.8 0.0 2.3e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CDW60688.1 - 1.6e-07 31.1 0.0 4.3e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CDW60688.1 - 3e-07 30.2 0.0 5.8e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CDW60688.1 - 0.036 13.8 0.0 0.062 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.6 CDW60688.1 - 0.098 12.3 0.0 0.52 9.9 0.0 2.1 3 1 1 4 4 4 0 ATP-grasp domain ADH_zinc_N PF00107.26 CDW60689.1 - 3.9e-14 52.7 0.1 7.4e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CDW60689.1 - 3.3e-05 23.7 0.1 0.0002 21.2 0.0 2.3 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CDW60689.1 - 0.00067 19.2 0.1 0.0012 18.4 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 CDW60689.1 - 0.00087 18.8 0.1 0.0016 17.9 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AlaDh_PNT_C PF01262.21 CDW60689.1 - 0.0017 17.7 1.0 0.0026 17.1 1.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 CDW60689.1 - 0.0091 15.7 0.5 0.015 15.1 0.5 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DapB_N PF01113.20 CDW60689.1 - 0.011 15.8 0.1 0.81 9.8 0.0 2.4 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus AAA_28 PF13521.6 CDW60689.1 - 0.057 13.7 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain THF_DHG_CYH_C PF02882.19 CDW60689.1 - 0.11 11.8 0.1 0.27 10.5 0.1 1.6 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 CDW60689.1 - 0.14 11.5 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CDW60689.1 - 0.17 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Phage_holin_3_3 PF16083.5 CDW60689.1 - 6 7.1 7.5 0.34 11.1 1.6 2.0 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III GAPES4 PF17157.4 CDW60690.1 - 9.9e-35 118.9 0.0 1.3e-34 118.5 0.0 1.2 1 0 0 1 1 1 1 Gammaproteobacterial periplasmic sensor domain LapA_dom PF06305.11 CDW60690.1 - 0.36 10.7 2.1 1.1 9.1 0.3 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Nucleos_tra2_C PF07662.13 CDW60691.1 - 7.8e-70 234.9 10.8 7.8e-70 234.9 10.8 2.3 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CDW60691.1 - 5.8e-23 81.3 1.9 5.8e-23 81.3 1.9 3.6 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 CDW60691.1 - 0.0004 20.6 6.8 0.0004 20.6 6.8 3.0 2 1 0 2 2 2 1 Nucleoside recognition gag-asp_proteas PF13975.6 CDW60692.1 - 2.1e-07 31.4 0.0 6.9e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW60692.1 - 0.0006 20.4 0.0 0.0011 19.5 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 CDW60692.1 - 0.069 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Retroviral aspartyl protease RVP PF00077.20 CDW60692.1 - 0.15 12.4 0.0 0.52 10.6 0.0 1.9 1 1 0 1 1 1 0 Retroviral aspartyl protease Asp_protease PF09668.10 CDW60692.1 - 0.16 11.7 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Aspartyl protease SBP_bac_5 PF00496.22 CDW60697.1 - 1.4e-87 294.1 9.5 1.9e-87 293.7 9.5 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle BPD_transp_1 PF00528.22 CDW60697.1 - 2e-34 118.9 17.1 2e-34 118.9 17.1 2.4 3 0 0 3 3 3 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 CDW60697.1 - 1.5e-13 50.5 1.4 1.5e-13 50.5 1.4 3.0 4 0 0 4 4 4 1 N-terminal TM domain of oligopeptide transport permease C MarC PF01914.17 CDW60698.1 - 9.4e-65 217.8 6.9 1e-64 217.7 6.9 1.0 1 0 0 1 1 1 1 MarC family integral membrane protein YrvL PF14184.6 CDW60698.1 - 0.32 11.1 10.7 1.8 8.7 2.2 2.4 2 0 0 2 2 2 0 Regulatory protein YrvL Trp_oprn_chp PF09534.10 CDW60698.1 - 0.63 9.8 2.2 2.5 7.9 0.1 2.5 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) PNTB_4TM PF12769.7 CDW60698.1 - 0.79 10.2 7.9 5.2 7.6 0.7 2.7 2 1 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch SPW PF03779.14 CDW60698.1 - 2.1 8.0 9.1 0.15 11.6 1.4 2.7 2 1 1 3 3 3 0 SPW repeat DUF3087 PF11286.8 CDW60698.1 - 2.6 7.5 4.9 0.56 9.7 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) Phage_holin_1 PF04531.13 CDW60698.1 - 8.6 7.0 6.8 1.2 9.7 1.4 2.1 2 1 0 2 2 2 0 Bacteriophage holin Fe-ADH PF00465.19 CDW60699.1 - 1.1e-114 383.0 0.3 1.7e-114 382.4 0.3 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Aldedh PF00171.22 CDW60699.1 - 1.8e-29 102.6 2.9 9.2e-29 100.2 2.9 1.8 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Fe-ADH_2 PF13685.6 CDW60699.1 - 4e-16 59.5 1.3 1.2e-06 28.4 1.6 2.6 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase HTH_AsnC-type PF13404.6 CDW60699.1 - 0.077 12.8 0.5 0.36 10.7 0.0 2.2 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Haspin_kinase PF12330.8 CDW60700.1 - 3.3e-17 62.5 0.1 4.3e-17 62.1 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Nnf1 PF03980.14 CDW60700.1 - 0.032 14.6 1.2 0.068 13.5 1.2 1.5 1 0 0 1 1 1 0 Nnf1 Pkinase PF00069.25 CDW60700.1 - 0.036 13.4 0.1 0.053 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein kinase domain BLOC1S3 PF15753.5 CDW60700.1 - 0.06 13.5 1.4 0.095 12.8 1.4 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 RRM_1 PF00076.22 CDW60701.1 - 6e-13 48.4 0.0 8.9e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 CDW60701.1 - 0.024 14.3 0.1 0.04 13.6 0.1 1.4 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DUF4778 PF16008.5 CDW60701.1 - 0.033 14.3 2.7 0.035 14.2 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) RNA_bind PF08675.11 CDW60701.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain Apt1 PF10351.9 CDW60701.1 - 0.72 8.6 4.5 0.82 8.5 4.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4614 PF15391.6 CDW60701.1 - 1.4 8.9 5.2 1.7 8.6 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Spem1 PF15670.5 CDW60701.1 - 2 8.0 6.0 2.7 7.5 6.0 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 EB PF01683.18 CDW60702.1 - 8.5e-21 74.0 78.1 1.6e-09 37.9 7.7 6.4 5 2 1 6 6 6 4 EB module Piwi PF02171.17 CDW60704.1 - 2.6e-91 306.0 0.0 6.1e-91 304.8 0.0 1.6 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.22 CDW60704.1 - 1.8e-16 60.2 0.0 3.3e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 CDW60704.1 - 9e-12 45.8 0.1 1.6e-11 44.9 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 CDW60704.1 - 2.3e-11 43.9 0.0 6.1e-11 42.5 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 CDW60704.1 - 3.8e-10 39.3 0.1 1.1e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 Argonaute linker 1 domain ArgoMid PF16487.5 CDW60704.1 - 5.2e-08 33.0 0.0 1.4e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 Mid domain of argonaute zn-ribbon_14 PF16503.5 CDW60706.1 - 0.028 13.9 0.4 0.082 12.4 0.4 1.9 1 0 0 1 1 1 0 Zinc-ribbon Adenosine_kin PF04008.14 CDW60706.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Adenosine specific kinase zf-TFIIIC PF12660.7 CDW60706.1 - 0.25 11.3 4.1 12 5.9 3.4 2.7 1 1 0 1 1 1 0 Putative zinc-finger of transcription factor IIIC complex Proton_antipo_M PF00361.20 CDW60709.1 - 3.8e-11 42.7 13.2 1.6e-10 40.7 13.0 1.9 1 1 0 1 1 1 1 Proton-conducting membrane transporter Asn_synthase PF00733.21 CDW60710.1 - 5.5e-105 351.9 0.5 3.8e-60 204.4 0.1 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 CDW60710.1 - 1.2e-42 144.7 0.1 2.9e-42 143.5 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CDW60710.1 - 3.4e-37 127.6 0.0 1.1e-36 125.9 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CDW60710.1 - 1.7e-09 37.4 0.0 3.5e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 CDW60710.1 - 0.017 14.2 0.0 0.033 13.3 0.0 1.5 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.16 CDW60710.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Hydrolase_6 PF13344.6 CDW60711.1 - 1.3e-22 79.8 0.0 2.4e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CDW60711.1 - 6.3e-20 71.0 0.0 1.5e-19 69.9 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CDW60711.1 - 4.9e-13 49.9 0.1 4.8e-12 46.6 0.1 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CDW60711.1 - 3.6e-10 40.2 0.0 3.6e-09 37.0 0.0 2.1 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Glucosamine_iso PF01182.20 CDW60712.1 - 1.2e-21 77.6 0.0 1.7e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PTS_EIIC PF02378.18 CDW60713.1 - 5.8e-47 160.3 18.8 6.8e-47 160.1 18.8 1.1 1 0 0 1 1 1 1 Phosphotransferase system, EIIC DUF572 PF04502.13 CDW60714.1 - 1.5e-40 139.9 12.8 1.6e-40 139.8 12.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) GRDP-like PF07173.12 CDW60714.1 - 0.0056 17.3 3.3 0.0068 17.1 3.3 1.1 1 0 0 1 1 1 1 Glycine-rich domain-containing protein-like TTR-52 PF01060.23 CDW60715.1 - 3.5e-24 85.3 0.1 5.2e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 Transthyretin-like family HTH_27 PF13463.6 CDW60715.1 - 0.037 14.5 0.0 0.053 14.0 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain FrhB_FdhB_C PF04432.13 CDW60715.1 - 0.053 13.4 0.1 0.072 12.9 0.1 1.2 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus PRP38 PF03371.15 CDW60716.1 - 2e-61 206.9 0.2 2.5e-61 206.5 0.2 1.1 1 0 0 1 1 1 1 PRP38 family RILP PF11461.8 CDW60716.1 - 0.0079 16.4 0.2 0.019 15.2 0.2 1.6 1 0 0 1 1 1 1 Rab interacting lysosomal protein MMR_HSR1 PF01926.23 CDW60717.1 - 3e-22 78.8 0.1 5.2e-22 78.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_M PF16360.5 CDW60717.1 - 4.7e-10 39.9 6.1 4.7e-10 39.9 6.1 2.0 2 0 0 2 2 2 1 GTP-binding GTPase Middle Region FeoB_N PF02421.18 CDW60717.1 - 2.2e-08 33.8 0.0 3.3e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CDW60717.1 - 5.1e-07 29.7 0.1 0.025 14.5 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 CDW60717.1 - 4.9e-06 26.1 0.6 3.3e-05 23.4 0.6 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CDW60717.1 - 1e-05 25.2 0.3 0.011 15.3 0.2 2.5 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CDW60717.1 - 0.00081 19.5 0.2 0.12 12.4 0.0 2.4 1 1 1 2 2 2 1 Dynamin family Roc PF08477.13 CDW60717.1 - 0.00097 19.3 0.1 0.59 10.4 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 CDW60717.1 - 0.0012 18.4 2.0 0.16 11.6 0.5 2.4 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 CDW60717.1 - 0.0013 18.7 0.0 0.0023 17.9 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain ATP_bind_1 PF03029.17 CDW60717.1 - 0.0013 18.5 0.4 0.0051 16.6 0.1 1.8 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein TniB PF05621.11 CDW60717.1 - 0.0016 17.9 0.0 0.0061 16.0 0.0 1.9 1 1 1 2 2 2 1 Bacterial TniB protein SRPRB PF09439.10 CDW60717.1 - 0.0029 17.0 0.0 0.005 16.3 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 CDW60717.1 - 0.0081 15.8 0.0 0.027 14.1 0.0 1.8 1 1 0 1 1 1 1 Ras family G-alpha PF00503.20 CDW60717.1 - 0.016 14.4 0.3 2.7 7.1 0.0 2.4 2 1 1 3 3 3 0 G-protein alpha subunit MnmE_helical PF12631.7 CDW60717.1 - 0.027 14.6 0.1 0.041 14.1 0.1 1.3 1 0 0 1 1 1 0 MnmE helical domain ABC_tran PF00005.27 CDW60717.1 - 0.032 14.7 0.0 0.077 13.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter DUF4011 PF13195.6 CDW60717.1 - 0.067 13.1 0.0 0.13 12.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4011) DHR10 PF18595.1 CDW60717.1 - 9.4 6.3 10.3 0.74 9.9 3.2 2.3 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain Band_7 PF01145.25 CDW60718.1 - 1e-30 107.1 1.0 1e-30 107.1 1.0 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family HflK_N PF12221.8 CDW60718.1 - 2.1e-15 56.4 13.5 6.3e-15 54.9 13.5 1.9 1 0 0 1 1 1 1 Bacterial membrane protein N terminal DivIVA PF05103.13 CDW60718.1 - 0.078 13.1 2.5 0.14 12.2 2.5 1.4 1 0 0 1 1 1 0 DivIVA protein SCAB_CC PF16712.5 CDW60718.1 - 0.092 12.6 0.4 0.17 11.7 0.4 1.4 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein GHMP_kinases_C PF08544.13 CDW60718.1 - 0.22 11.9 0.9 0.71 10.3 0.9 1.9 1 0 0 1 1 1 0 GHMP kinases C terminal Band_7 PF01145.25 CDW60719.1 - 1.5e-34 119.5 0.7 2.1e-34 119.1 0.7 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family CCP_MauG PF03150.14 CDW60719.1 - 0.2 12.3 1.3 0.81 10.3 1.4 2.1 2 1 0 2 2 2 0 Di-haem cytochrome c peroxidase Adenylsucc_synt PF00709.21 CDW60720.1 - 1.2e-178 594.4 0.0 1.4e-178 594.2 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Rrf2 PF02082.20 CDW60721.1 - 1.2e-15 57.6 0.3 1.9e-15 56.9 0.3 1.4 1 0 0 1 1 1 1 Transcriptional regulator HTH_27 PF13463.6 CDW60721.1 - 0.00053 20.4 0.0 0.0015 19.0 0.0 1.8 3 0 0 3 3 3 1 Winged helix DNA-binding domain TrmB PF01978.19 CDW60721.1 - 0.018 14.9 0.5 0.06 13.2 0.1 2.0 2 1 1 3 3 3 0 Sugar-specific transcriptional regulator TrmB HTH_Crp_2 PF13545.6 CDW60721.1 - 0.026 14.5 0.1 0.073 13.1 0.0 1.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain MarR_2 PF12802.7 CDW60721.1 - 0.031 14.2 0.1 0.12 12.3 0.0 2.0 3 0 0 3 3 3 0 MarR family HTH_36 PF13730.6 CDW60721.1 - 0.059 13.3 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain GntR PF00392.21 CDW60721.1 - 0.074 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family SgrR_N PF12793.7 CDW60721.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.6 2 0 0 2 2 2 0 Sugar transport-related sRNA regulator N-term RNB PF00773.19 CDW60722.1 - 1.4e-111 373.0 0.0 1.8e-111 372.6 0.0 1.1 1 0 0 1 1 1 1 RNB domain OB_RNB PF08206.11 CDW60722.1 - 8.2e-30 102.3 0.5 3.4e-22 77.9 0.1 2.5 2 0 0 2 2 2 2 Ribonuclease B OB domain CSD2 PF17876.1 CDW60722.1 - 5e-26 90.7 0.1 2.1e-23 82.3 0.0 2.5 2 0 0 2 2 2 2 Cold shock domain HTH_12 PF08461.10 CDW60722.1 - 1.3e-13 50.7 0.8 2.8e-13 49.6 0.8 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain OB_Dis3 PF17849.1 CDW60722.1 - 0.04 13.9 0.0 0.091 12.8 0.0 1.5 1 0 0 1 1 1 0 Dis3-like cold-shock domain 2 (CSD2) Rho_RNA_bind PF07497.12 CDW60722.1 - 0.068 13.1 0.1 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Rho termination factor, RNA-binding domain MetOD2 PF18548.1 CDW60722.1 - 0.13 12.3 1.4 0.21 11.7 0.5 1.8 2 0 0 2 2 2 0 Metanogen output domain 2 Sucrose_synth PF00862.19 CDW60722.1 - 0.15 10.4 0.0 0.21 9.9 0.0 1.1 1 0 0 1 1 1 0 Sucrose synthase ABC_tran PF00005.27 CDW60723.1 - 7e-35 120.5 0.0 1.4e-34 119.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter NIL PF09383.10 CDW60723.1 - 1.4e-20 72.9 0.3 2.9e-20 71.9 0.3 1.6 1 0 0 1 1 1 1 NIL domain AAA_21 PF13304.6 CDW60723.1 - 2.6e-06 27.5 0.9 0.0012 18.7 0.0 2.6 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CDW60723.1 - 3.5e-05 23.3 0.3 0.00037 20.0 0.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CDW60723.1 - 0.00031 21.0 0.4 0.014 15.6 0.4 2.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CDW60723.1 - 0.0077 16.0 0.1 0.034 13.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CDW60723.1 - 0.01 15.5 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CDW60723.1 - 0.011 15.6 0.1 0.027 14.4 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 CDW60723.1 - 0.018 15.1 0.1 0.057 13.5 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 CDW60723.1 - 0.023 15.1 0.6 0.054 13.9 0.6 1.8 1 1 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 CDW60723.1 - 0.031 14.5 0.7 0.23 11.7 0.7 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CDW60723.1 - 0.082 13.4 1.7 0.12 12.8 0.1 2.0 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CDW60723.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin FTSW_RODA_SPOVE PF01098.19 CDW60724.1 - 1.1e-52 179.3 16.3 1.3e-52 179.0 16.3 1.1 1 0 0 1 1 1 1 Cell cycle protein GCV_H PF01597.19 CDW60724.1 - 2.3e-16 59.8 0.1 3.8e-16 59.1 0.1 1.3 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 CDW60724.1 - 2.9e-08 33.4 0.3 5.3e-08 32.6 0.3 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme PTS_EIIA_1 PF00358.20 CDW60724.1 - 0.001 18.8 0.0 0.099 12.4 0.0 2.4 2 0 0 2 2 2 1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 HlyD_3 PF13437.6 CDW60724.1 - 0.031 15.0 0.2 0.23 12.2 0.0 2.2 2 1 1 3 3 3 0 HlyD family secretion protein Syndecan PF01034.20 CDW60724.1 - 7.9 6.5 8.5 21 5.1 0.6 3.2 3 0 0 3 3 3 0 Syndecan domain EMG1 PF03587.14 CDW60725.1 - 4.8e-76 254.8 0.2 5.6e-76 254.5 0.2 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase HipN PF18253.1 CDW60726.1 - 4.9e-13 48.5 0.1 9.7e-13 47.6 0.1 1.4 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain TPR_1 PF00515.28 CDW60726.1 - 1.3e-10 40.7 3.4 0.00013 21.7 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CDW60726.1 - 2.6e-08 33.3 5.2 0.011 15.7 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 CDW60726.1 - 6.4e-06 25.8 0.8 0.0027 17.4 0.0 3.1 3 1 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 CDW60726.1 - 1.7e-05 24.9 0.5 0.027 14.9 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CDW60726.1 - 0.00044 20.8 2.6 0.19 12.6 0.1 4.2 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 CDW60726.1 - 0.00067 19.7 0.2 0.042 14.0 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 CDW60726.1 - 0.0025 17.8 2.3 0.011 15.7 0.1 2.4 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 CDW60726.1 - 0.018 15.5 0.1 0.055 14.0 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 CDW60726.1 - 0.046 13.9 1.3 2.3 8.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CDW60726.1 - 0.049 14.3 0.8 1.2 9.9 0.0 2.5 2 1 1 3 3 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDW60726.1 - 0.08 13.2 4.4 0.74 10.1 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat SH2 PF00017.24 CDW60728.1 - 3.5e-12 46.3 0.2 8.5e-12 45.0 0.2 1.7 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 CDW60728.1 - 3.1e-07 30.6 0.1 8.2e-07 29.3 0.1 1.8 1 0 0 1 1 1 1 SOCS box Glyco_hydro_19 PF00182.19 CDW60729.1 - 1.1e-27 97.4 7.4 2.9e-20 73.2 0.3 2.4 3 0 0 3 3 3 2 Chitinase class I ArfGap PF01412.18 CDW60730.1 - 1.4e-30 105.8 1.7 9.4e-30 103.1 1.7 2.1 1 1 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 CDW60730.1 - 1.7e-13 51.0 0.0 3.1e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 PH domain BAR_3 PF16746.5 CDW60730.1 - 9.6e-13 48.4 0.8 1.6e-12 47.6 0.8 1.3 1 0 0 1 1 1 1 BAR domain of APPL family Ank_2 PF12796.7 CDW60730.1 - 3.6e-11 43.5 1.1 3.3e-10 40.4 0.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CDW60730.1 - 7.3e-10 38.9 0.3 2.7e-09 37.1 0.2 2.1 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CDW60730.1 - 2.7e-08 33.4 0.2 0.00055 20.2 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 CDW60730.1 - 5.1e-08 33.3 1.5 1.6e-05 25.3 0.2 3.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 CDW60730.1 - 2.5e-07 30.9 2.1 0.22 12.0 0.0 4.2 4 1 0 4 4 4 2 Ankyrin repeat PH_11 PF15413.6 CDW60730.1 - 0.001 19.4 1.5 0.0089 16.4 0.6 2.9 2 2 1 3 3 3 1 Pleckstrin homology domain NADHdh PF00146.21 CDW60733.1 - 4.4e-14 52.5 0.4 5.9e-14 52.1 0.4 1.3 1 1 0 1 1 1 1 NADH dehydrogenase CBM_48 PF02922.18 CDW60734.1 - 9e-53 176.6 0.2 6e-26 90.6 0.0 4.2 4 0 0 4 4 4 3 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) GlgX_C PF18390.1 CDW60734.1 - 3.8e-43 145.2 0.2 9.5e-43 143.9 0.2 1.7 1 0 0 1 1 1 1 Glycogen debranching enzyme C-terminal domain Alpha-amylase PF00128.24 CDW60734.1 - 6.2e-27 95.1 0.0 8.4e-09 35.4 0.0 5.2 3 2 1 4 4 4 4 Alpha amylase, catalytic domain Alpha-amylase_C PF02806.18 CDW60734.1 - 9.3e-17 61.3 0.0 4.4e-16 59.1 0.0 2.1 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain Glyco_hydro_70 PF02324.16 CDW60734.1 - 4.7e-05 21.8 0.0 0.046 11.9 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 70 Malt_amylase_C PF16657.5 CDW60734.1 - 0.049 13.8 0.0 0.42 10.8 0.0 2.6 3 0 0 3 3 3 0 Maltogenic Amylase, C-terminal domain Semialdhyde_dhC PF02774.18 CDW60735.1 - 6.9e-61 205.5 0.0 8.7e-61 205.2 0.0 1.1 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CDW60735.1 - 2.3e-24 86.2 0.0 4.1e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain MarC PF01914.17 CDW60736.1 - 6.1e-50 169.4 15.8 6.8e-50 169.3 15.8 1.0 1 0 0 1 1 1 1 MarC family integral membrane protein TerC PF03741.16 CDW60736.1 - 0.035 13.8 1.0 0.035 13.8 1.0 2.2 2 0 0 2 2 2 0 Integral membrane protein TerC family ST7 PF04184.12 CDW60736.1 - 0.041 12.3 0.1 0.054 12.0 0.1 1.1 1 0 0 1 1 1 0 ST7 protein GntP_permease PF02447.16 CDW60737.1 - 3.7e-103 345.6 15.5 4.1e-103 345.4 15.5 1.0 1 0 0 1 1 1 1 GntP family permease CitMHS PF03600.16 CDW60737.1 - 3.8e-07 29.6 14.8 5.9e-07 29.0 14.8 1.3 1 0 0 1 1 1 1 Citrate transporter LLGL PF08366.13 CDW60739.1 - 0.0044 17.3 0.1 0.0092 16.3 0.1 1.5 1 0 0 1 1 1 1 LLGL2 Collagen PF01391.18 CDW60740.1 - 5.4e-12 45.3 81.8 3e-07 30.1 30.1 4.9 4 1 2 6 6 6 3 Collagen triple helix repeat (20 copies) JAB PF01398.21 CDW60742.1 - 2.7e-29 101.5 0.1 7.5e-29 100.1 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CDW60742.1 - 9.1e-25 87.3 0.1 1.9e-24 86.2 0.1 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function ATP-synt_ab_N PF02874.23 CDW60743.1 - 2.7e-19 69.4 1.1 6.7e-19 68.2 1.1 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab PF00006.25 CDW60743.1 - 1e-14 54.7 0.3 1.6e-14 54.1 0.3 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain HAS-barrel PF09378.10 CDW60743.1 - 0.025 14.7 0.8 0.1 12.8 0.9 1.9 1 1 0 1 1 1 0 HAS barrel domain TniB PF05621.11 CDW60743.1 - 0.15 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein CSD2 PF17876.1 CDW60743.1 - 0.38 10.9 2.0 3.4 7.9 0.3 2.3 2 0 0 2 2 2 0 Cold shock domain Dus PF01207.17 CDW60744.1 - 2.1e-21 76.3 0.0 2.5e-21 76.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) dsrm PF00035.26 CDW60744.1 - 0.00022 21.9 0.0 0.00048 20.8 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif HSP70 PF00012.20 CDW60746.1 - 4.2e-81 272.9 1.9 4.6e-81 272.8 1.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDW60746.1 - 0.00034 19.6 0.0 0.00053 18.9 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Lustrin_cystein PF14625.6 CDW60747.1 - 4.5e-23 81.3 33.5 1.4e-08 35.0 5.6 3.1 3 0 0 3 3 3 3 Lustrin, cysteine-rich repeated domain Inhibitor_I36 PF03995.13 CDW60747.1 - 0.00032 20.5 9.0 0.19 11.7 0.9 3.3 3 0 0 3 3 3 2 Peptidase inhibitor family I36 Tme5_EGF_like PF09064.10 CDW60747.1 - 0.0048 16.8 1.4 0.0048 16.8 1.4 3.4 3 1 0 3 3 3 1 Thrombomodulin like fifth domain, EGF-like HTH_Tnp_Tc5 PF03221.16 CDW60749.1 - 0.068 13.2 0.1 0.15 12.1 0.1 1.6 1 1 0 1 1 1 0 Tc5 transposase DNA-binding domain Kunitz_BPTI PF00014.23 CDW60750.1 - 2.7e-37 126.8 25.0 2.1e-15 56.7 1.5 3.1 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain SAD_SRA PF02182.17 CDW60750.1 - 0.00051 19.8 0.9 0.35 10.6 0.1 2.8 2 1 1 3 3 3 2 SAD/SRA domain PAN_2 PF08276.11 CDW60750.1 - 0.89 9.7 9.3 7.7 6.7 1.0 3.5 3 0 0 3 3 3 0 PAN-like domain TraE PF05309.11 CDW60751.1 - 9.9e-57 191.2 0.5 1.1e-56 191.1 0.5 1.0 1 0 0 1 1 1 1 TraE protein Herpes_UL37_2 PF07413.11 CDW60751.1 - 0.074 12.3 0.3 0.11 11.8 0.3 1.4 1 1 0 1 1 1 0 Betaherpesvirus immediate-early glycoprotein UL37 TraK PF06586.11 CDW60752.1 - 8.3e-40 136.9 0.0 1.3e-39 136.2 0.0 1.3 1 0 0 1 1 1 1 TraK protein TrbI PF03743.14 CDW60752.1 - 6.9e-30 104.3 3.0 1.9e-29 102.9 0.4 2.3 2 0 0 2 2 2 1 Bacterial conjugation TrbI-like protein CALCOCO1 PF07888.11 CDW60752.1 - 0.047 12.6 1.5 0.069 12.0 1.5 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Lebercilin PF15619.6 CDW60752.1 - 0.14 11.8 5.6 0.092 12.4 3.4 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DivIC PF04977.15 CDW60752.1 - 0.74 9.6 4.3 1.6 8.5 4.3 1.5 1 0 0 1 1 1 0 Septum formation initiator DEDD_Tnp_IS110 PF01548.17 CDW60753.1 - 1.8e-44 151.3 0.1 3.2e-44 150.5 0.1 1.4 1 0 0 1 1 1 1 Transposase Transposase_20 PF02371.16 CDW60753.1 - 8.6e-23 80.5 0.3 3.8e-22 78.4 0.6 2.0 2 0 0 2 2 2 1 Transposase IS116/IS110/IS902 family HHH_5 PF14520.6 CDW60753.1 - 0.00072 20.1 0.9 1.7 9.3 0.0 3.0 3 0 0 3 3 3 2 Helix-hairpin-helix domain TraV PF09676.10 CDW60754.1 - 5.8e-24 85.6 1.4 6.9e-24 85.3 1.4 1.1 1 0 0 1 1 1 1 Type IV conjugative transfer system lipoprotein (TraV) zf-C2H2 PF00096.26 CDW60755.1 - 4.3e-18 64.7 68.5 3.3e-05 24.1 3.0 8.0 9 0 0 9 9 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW60755.1 - 1.5e-17 62.8 59.8 0.00026 21.6 2.0 8.3 8 0 0 8 8 8 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CDW60755.1 - 2.4e-06 27.7 51.1 0.032 14.7 2.1 8.8 8 2 0 8 8 8 5 Zinc-finger double domain zf-met PF12874.7 CDW60755.1 - 8.8e-06 25.9 41.5 0.0034 17.7 1.1 8.0 8 0 0 8 8 8 3 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CDW60755.1 - 0.00016 22.0 42.1 0.0017 18.6 5.2 6.4 2 2 4 6 6 6 3 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 CDW60755.1 - 0.002 17.8 5.3 0.05 13.4 0.1 6.2 7 0 0 7 7 7 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 CDW60755.1 - 0.0021 18.3 43.3 0.15 12.4 1.2 8.2 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 CDW60755.1 - 0.012 16.3 27.7 0.31 11.7 1.2 5.6 2 1 4 6 6 6 0 Zinc finger C2H2-type, 3 repeats zf-C2HC_2 PF13913.6 CDW60755.1 - 0.012 15.5 0.2 0.012 15.5 0.2 4.9 6 0 0 6 6 6 0 zinc-finger of a C2HC-type zf-C2HE PF16278.5 CDW60755.1 - 0.034 14.6 3.7 0.034 14.6 3.7 5.7 4 3 1 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger C1_1 PF00130.22 CDW60755.1 - 0.037 13.9 0.7 0.037 13.9 0.7 5.5 2 2 3 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_6 PF13912.6 CDW60755.1 - 0.039 14.0 1.5 0.039 14.0 1.5 7.0 7 1 0 7 7 6 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 CDW60755.1 - 0.049 14.4 25.2 0.29 11.9 1.3 4.6 1 1 4 5 5 5 0 zinc-ribbon family zf-C2H2_12 PF18658.1 CDW60755.1 - 0.097 12.3 0.3 0.097 12.3 0.3 5.5 5 1 1 6 6 6 0 Zinc-finger C2H2-type DAAD PF18752.1 CDW60755.1 - 0.15 11.9 7.0 0.43 10.4 6.6 2.1 1 1 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase Prok-RING_1 PF14446.6 CDW60755.1 - 2.4 8.2 21.8 1 9.3 0.1 6.5 7 0 0 7 7 7 0 Prokaryotic RING finger family 1 zf-C2H2_9 PF16293.5 CDW60755.1 - 5.9 6.8 13.1 14 5.6 0.2 4.8 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) Motile_Sperm PF00635.26 CDW60757.1 - 1.3e-09 37.9 0.1 1.7e-09 37.4 0.1 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain tRNA-synt_1 PF00133.22 CDW60758.1 - 6.1e-31 107.3 0.0 5.4e-16 58.0 0.0 2.4 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 CDW60758.1 - 7.9e-08 31.4 0.0 1.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) HSP70 PF00012.20 CDW60759.1 - 3e-92 309.7 2.8 3.4e-92 309.6 2.8 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CDW60759.1 - 1.6e-06 27.2 0.2 0.00092 18.1 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein F_bP_aldolase PF01116.20 CDW60760.1 - 7.6e-99 330.7 1.1 8.5e-99 330.5 1.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II FMN_dh PF01070.18 CDW60760.1 - 0.004 16.2 0.1 0.0058 15.7 0.1 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Nuc_H_symport PF03825.16 CDW60761.1 - 4.5e-180 598.9 31.2 5.8e-180 598.5 31.2 1.1 1 0 0 1 1 1 1 Nucleoside H+ symporter ADP_ribosyl_GH PF03747.14 CDW60761.1 - 5.9e-57 193.6 1.7 5.9e-57 193.6 1.7 1.7 2 0 0 2 2 2 1 ADP-ribosylglycohydrolase PfkB PF00294.24 CDW60761.1 - 1.9e-52 178.5 0.0 3.1e-52 177.8 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase MFS_1_like PF12832.7 CDW60761.1 - 5.5e-30 104.5 24.8 1.2e-29 103.4 24.8 1.5 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 CDW60761.1 - 2.2e-19 69.6 57.6 3.1e-15 56.0 40.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily UTRA PF07702.13 CDW60762.1 - 4.1e-17 62.4 0.0 6.8e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 UTRA domain GntR PF00392.21 CDW60762.1 - 1.2e-16 60.1 0.4 3.2e-16 58.7 0.1 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, gntR family HTH_Crp_2 PF13545.6 CDW60762.1 - 5.2e-05 23.1 0.1 0.0001 22.2 0.1 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 CDW60762.1 - 5.8e-05 22.6 0.1 0.00013 21.4 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_DeoR PF08220.12 CDW60762.1 - 0.00012 21.7 0.1 0.00025 20.7 0.1 1.5 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_11 PF08279.12 CDW60762.1 - 0.00016 21.6 0.0 0.00036 20.4 0.0 1.6 1 0 0 1 1 1 1 HTH domain TrmB PF01978.19 CDW60762.1 - 0.0047 16.8 0.0 0.0089 15.9 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF1670 PF07900.11 CDW60762.1 - 0.0054 16.1 0.0 0.028 13.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1670) HTH_IclR PF09339.10 CDW60762.1 - 0.0096 15.7 0.1 0.02 14.7 0.1 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain RepL PF05732.11 CDW60762.1 - 0.012 15.0 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) Rrf2 PF02082.20 CDW60762.1 - 0.03 14.7 0.0 0.056 13.8 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator HTH_28 PF13518.6 CDW60762.1 - 0.039 14.1 0.0 0.084 13.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_41 PF14502.6 CDW60762.1 - 0.049 13.3 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Glyco_hydro_25 PF01183.20 CDW60763.1 - 4.3e-16 59.6 1.6 5.7e-16 59.2 1.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 UPF0054 PF02130.17 CDW60765.1 - 6e-05 22.8 0.3 2 8.3 0.0 4.3 1 1 2 3 3 3 3 Uncharacterized protein family UPF0054 AraC_binding_2 PF14525.6 CDW60765.1 - 0.0079 15.9 5.6 0.72 9.5 0.1 3.0 1 1 3 4 4 4 3 AraC-binding-like domain DUF2635 PF10948.8 CDW60765.1 - 0.041 13.6 0.4 5 6.9 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2635) DUF5629 PF18629.1 CDW60765.1 - 0.092 13.3 0.1 3.7 8.2 0.0 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5629) IF-2B PF01008.17 CDW60766.1 - 3.6e-60 203.6 0.0 4e-60 203.4 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF1719 PF08224.11 CDW60766.1 - 0.086 11.9 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1719) RNA_pol_Rpb6 PF01192.22 CDW60768.1 - 4.2e-14 52.2 0.2 7e-14 51.5 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 DUF4549 PF15082.6 CDW60768.1 - 0.0066 16.2 0.0 0.0084 15.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4549) Exo_endo_phos PF03372.23 CDW60769.1 - 1.3e-19 70.7 0.0 5.9e-19 68.5 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Cu2_monoox_C PF03712.15 CDW60770.1 - 1.1e-36 125.7 0.0 1.3e-35 122.2 0.0 2.1 2 0 0 2 2 2 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain NHL PF01436.21 CDW60770.1 - 2.6e-20 71.3 11.6 4.1e-08 32.9 0.2 5.0 5 0 0 5 5 5 3 NHL repeat Cu2_monooxygen PF01082.20 CDW60770.1 - 4.3e-17 62.6 0.2 7.8e-17 61.7 0.2 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain SGL PF08450.12 CDW60770.1 - 0.0029 17.2 0.3 0.062 12.9 0.1 2.6 1 1 3 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 CDW60770.1 - 0.073 13.0 0.0 0.24 11.3 0.0 1.8 1 1 0 1 1 1 0 Esterase-like activity of phytase Reg_prop PF07494.11 CDW60770.1 - 0.084 13.1 0.1 5.1 7.7 0.0 3.5 3 0 0 3 3 3 0 Two component regulator propeller Lactonase PF10282.9 CDW60770.1 - 0.1 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Retrotran_gag_3 PF14244.6 CDW60771.1 - 0.01 15.6 0.8 0.016 15.0 0.8 1.3 1 0 0 1 1 1 0 gag-polypeptide of LTR copia-type DUF4219 PF13961.6 CDW60771.1 - 0.098 12.4 1.9 0.18 11.5 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) zf-NADH-PPase PF09297.11 CDW60771.1 - 2.3 7.9 10.3 2.6 7.8 6.8 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain NUP50 PF08911.11 CDW60772.1 - 3.9e-12 46.7 0.6 2e-08 34.7 0.1 3.8 4 1 0 4 4 4 2 NUP50 (Nucleoporin 50 kDa) CAP_GLY PF01302.25 CDW60773.1 - 7.3e-21 74.0 0.3 1.1e-20 73.4 0.3 1.3 1 0 0 1 1 1 1 CAP-Gly domain PH_17 PF18012.1 CDW60774.1 - 3.2e-22 78.0 0.1 5.6e-22 77.2 0.1 1.4 1 0 0 1 1 1 1 PH domain PDZ PF00595.24 CDW60774.1 - 1.8e-18 66.6 0.3 2.8e-18 66.0 0.3 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 CDW60774.1 - 0.00056 19.7 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CDW60774.1 - 0.0018 18.5 0.1 0.0035 17.6 0.1 1.4 1 0 0 1 1 1 1 PDZ domain Laminin_G_2 PF02210.24 CDW60774.1 - 0.019 15.5 0.0 0.058 14.0 0.0 1.9 2 1 0 2 2 2 0 Laminin G domain PH_2 PF08458.10 CDW60774.1 - 0.14 12.5 0.0 0.48 10.8 0.0 2.0 2 0 0 2 2 2 0 Plant pleckstrin homology-like region E1-E2_ATPase PF00122.20 CDW60776.1 - 6e-16 58.5 1.3 7.7e-16 58.1 0.6 1.5 2 0 0 2 2 2 1 E1-E2 ATPase DUF2537 PF10801.8 CDW60777.1 - 0.15 12.3 0.4 0.21 11.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2537) Arginase PF00491.21 CDW60778.1 - 1.4e-71 241.3 1.5 3.6e-70 236.6 1.5 2.0 1 1 0 1 1 1 1 Arginase family UPF0489 PF12640.7 CDW60778.1 - 0.11 12.7 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 UPF0489 domain S-AdoMet_synt_C PF02773.16 CDW60779.1 - 3.7e-70 234.3 0.1 7.7e-70 233.2 0.0 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 CDW60779.1 - 5.4e-47 159.0 0.0 1.8e-46 157.3 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 CDW60779.1 - 2.8e-43 146.6 0.1 5.4e-43 145.7 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 CDW60779.1 - 0.13 11.0 0.6 1.1 7.9 0.1 2.4 2 1 1 3 3 3 0 S-adenosylmethionine synthetase (AdoMet synthetase) Sugar_tr PF00083.24 CDW60780.1 - 2.3e-104 349.8 24.6 1.4e-78 264.8 17.4 2.8 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CDW60780.1 - 3.6e-20 72.2 34.5 2.7e-16 59.4 28.7 3.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CDW60780.1 - 0.0024 16.5 7.3 0.0024 16.5 7.3 3.9 2 2 2 4 4 4 2 MFS/sugar transport protein An_peroxidase PF03098.15 CDW60781.1 - 1.7e-30 106.2 0.0 2.1e-30 105.9 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase LytR_cpsA_psr PF03816.14 CDW60782.1 - 6.5e-48 162.7 0.8 1.5e-47 161.6 0.8 1.6 1 0 0 1 1 1 1 Cell envelope-related transcriptional attenuator domain Sod_Fe_C PF02777.18 CDW60783.1 - 2.8e-42 143.0 0.1 5.7e-42 142.0 0.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CDW60783.1 - 5.1e-33 113.4 2.0 8.7e-33 112.7 2.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain LemA PF04011.12 CDW60783.1 - 0.011 15.6 0.1 0.018 14.9 0.1 1.2 1 0 0 1 1 1 0 LemA family 2-Hacid_dh_C PF02826.19 CDW60784.1 - 2.2e-50 170.5 0.0 2.9e-50 170.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1189 PF06691.11 CDW60784.1 - 2.5e-32 112.4 0.2 4e-32 111.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1189) NAD_binding_2 PF03446.15 CDW60784.1 - 1.8e-09 38.0 0.2 3.1e-09 37.2 0.2 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 CDW60784.1 - 1.6e-07 31.6 0.3 2.7e-07 30.8 0.3 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 CDW60784.1 - 8.6e-05 22.2 0.2 0.00015 21.4 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 CDW60784.1 - 0.00043 20.4 0.0 0.00074 19.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 CDW60784.1 - 0.015 14.6 0.5 0.037 13.3 0.5 1.7 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 CDW60784.1 - 0.051 14.2 0.0 0.11 13.1 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 CDW60784.1 - 0.09 12.0 0.3 0.16 11.1 0.1 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_33 PF10017.9 CDW60784.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Alg6_Alg8 PF03155.15 CDW60786.1 - 1.4e-70 238.7 9.5 1.6e-70 238.5 9.5 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Retrotran_gag_2 PF14223.6 CDW60787.1 - 3.4e-14 52.7 0.2 7.7e-14 51.5 0.2 1.6 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type DUF1758 PF05585.12 CDW60787.1 - 7.8e-06 25.8 0.0 0.00011 22.0 0.0 2.3 2 0 0 2 2 2 1 Putative peptidase (DUF1758) Retrotran_gag_3 PF14244.6 CDW60787.1 - 0.00052 19.8 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 gag-polypeptide of LTR copia-type RVT_1 PF00078.27 CDW60787.1 - 0.00074 19.1 0.1 0.0028 17.2 0.1 1.8 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4219 PF13961.6 CDW60787.1 - 0.043 13.5 0.0 0.12 12.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) ANAPC9 PF12856.7 CDW60787.1 - 0.044 14.0 0.1 0.1 12.8 0.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 9 DASH_Dad1 PF08649.10 CDW60787.1 - 0.93 9.7 4.1 0.51 10.6 0.4 2.5 3 0 0 3 3 3 0 DASH complex subunit Dad1 PNMA PF14893.6 CDW60788.1 - 0.00016 21.2 0.0 0.00023 20.7 0.0 1.2 1 0 0 1 1 1 1 PNMA zf-CCHC PF00098.23 CDW60788.1 - 0.00019 21.4 0.6 0.00029 20.8 0.6 1.3 1 0 0 1 1 1 1 Zinc knuckle Retrotran_gag_2 PF14223.6 CDW60788.1 - 0.0053 16.4 0.3 0.011 15.5 0.0 1.6 2 0 0 2 2 2 1 gag-polypeptide of LTR copia-type Retrotrans_gag PF03732.17 CDW60788.1 - 0.037 14.3 0.0 0.099 12.9 0.0 1.8 2 0 0 2 2 2 0 Retrotransposon gag protein HSBP1 PF06825.12 CDW60788.1 - 0.1 12.5 0.7 0.1 12.5 0.7 1.8 2 0 0 2 2 2 0 Heat shock factor binding protein 1 UTRA PF07702.13 CDW60790.1 - 6.7e-35 120.0 0.3 1.3e-34 119.0 0.3 1.5 1 0 0 1 1 1 1 UTRA domain Peptidase_M20 PF01546.28 CDW60790.1 - 1.4e-29 103.3 0.0 2.6e-29 102.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 GntR PF00392.21 CDW60790.1 - 1.7e-15 56.4 0.0 9.3e-14 50.8 0.0 2.9 3 0 0 3 3 3 1 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 CDW60790.1 - 0.00056 19.8 0.0 0.0018 18.2 0.0 1.9 1 0 0 1 1 1 1 HTH domain Peptidase_M28 PF04389.17 CDW60790.1 - 0.012 15.4 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 M20_dimer PF07687.14 CDW60790.1 - 0.12 12.3 0.0 0.42 10.6 0.0 1.9 1 1 0 1 1 1 0 Peptidase dimerisation domain QueH PF02677.14 CDW60791.1 - 7e-63 211.9 4.3 8.4e-63 211.6 4.3 1.0 1 0 0 1 1 1 1 Epoxyqueuosine reductase QueH APOBEC1 PF18769.1 CDW60791.1 - 0.043 14.1 0.1 0.083 13.1 0.1 1.4 1 0 0 1 1 1 0 APOBEC1 AHH PF14412.6 CDW60791.1 - 0.062 13.4 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Sulfatase PF00884.23 CDW60792.1 - 1.7e-30 106.5 5.3 2.4e-30 106.0 5.3 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CDW60792.1 - 0.024 14.2 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase adh_short_C2 PF13561.6 CDW60793.1 - 6.5e-16 58.6 0.0 8.1e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CDW60793.1 - 1.4e-09 37.7 5.2 2.8e-09 36.7 0.2 2.2 2 1 1 3 3 3 1 short chain dehydrogenase KR PF08659.10 CDW60793.1 - 1e-05 25.5 0.6 0.0013 18.7 0.0 2.2 1 1 1 2 2 2 2 KR domain Epimerase PF01370.21 CDW60793.1 - 0.00021 20.8 0.0 0.00035 20.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CDW60793.1 - 0.00064 18.9 0.1 0.00089 18.4 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 CDW60793.1 - 0.0026 18.0 0.5 0.03 14.6 0.5 2.1 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 CDW60793.1 - 0.1 12.5 0.7 0.41 10.5 0.7 2.0 1 1 0 1 1 1 0 NAD(P)H-binding PRTP PF01366.18 CDW60793.1 - 0.21 9.6 0.0 0.28 9.2 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein CLU_N PF15044.6 CDW60794.1 - 1e-13 51.4 0.0 1.7e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term Proton_antipo_M PF00361.20 CDW60795.1 - 3.1e-09 36.5 12.9 4.1e-09 36.1 12.9 1.3 1 0 0 1 1 1 1 Proton-conducting membrane transporter DUF2207 PF09972.9 CDW60795.1 - 5.6 5.6 6.5 2.9 6.5 4.7 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) CoA_binding_3 PF13727.6 CDW60797.1 - 1.6e-06 28.2 0.3 1.6e-06 28.2 0.3 1.6 2 0 0 2 2 2 1 CoA-binding domain PGM_PMM_I PF02878.16 CDW60798.1 - 1.6e-32 112.1 0.0 7.8e-32 109.9 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CDW60798.1 - 4e-26 91.4 0.0 6.3e-26 90.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CDW60798.1 - 2.9e-22 79.2 0.1 5.4e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CDW60798.1 - 3e-09 36.9 0.1 7.2e-09 35.7 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain GDP_Man_Dehyd PF16363.5 CDW60799.1 - 2.5e-65 221.1 0.0 2.9e-65 220.9 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CDW60799.1 - 6.8e-18 65.0 0.0 9.2e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PBP PF01161.20 CDW60800.1 - 3.4e-20 72.7 0.0 4.5e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein gag-asp_proteas PF13975.6 CDW60801.1 - 0.00063 20.3 0.0 0.0011 19.5 0.0 1.4 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW60801.1 - 0.0035 18.0 0.0 0.0084 16.7 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease DUF5641 PF18701.1 CDW60802.1 - 7.5e-27 93.3 1.8 9e-27 93.1 1.8 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5641) DUF1759 PF03564.15 CDW60803.1 - 9.7e-26 90.5 0.1 2.5e-25 89.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 CDW60803.1 - 5.2e-17 62.1 0.0 2.7e-16 59.8 0.0 2.1 2 0 0 2 2 2 1 Putative peptidase (DUF1758) Integrase_H2C2 PF17921.1 CDW60803.1 - 1.3e-09 38.0 0.5 5.1e-09 36.1 0.2 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CDW60803.1 - 4.1e-07 30.2 0.0 1.4e-06 28.5 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 CDW60803.1 - 0.07 12.9 0.0 0.42 10.4 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain zf-CCHC_4 PF14392.6 CDW60803.1 - 1.5 8.6 4.9 1.1 9.0 2.2 2.3 2 0 0 2 2 2 0 Zinc knuckle Thiolase_C PF02803.18 CDW60804.1 - 1.2e-43 147.7 0.5 2.2e-42 143.6 0.1 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain Thiolase_N PF00108.23 CDW60804.1 - 5.6e-37 127.5 11.4 1e-34 120.1 4.1 2.3 1 1 1 2 2 2 2 Thiolase, N-terminal domain ketoacyl-synt PF00109.26 CDW60804.1 - 5.7e-05 22.8 2.7 0.0068 16.0 0.4 2.6 1 1 2 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 CDW60804.1 - 0.0028 16.4 2.7 0.011 14.5 2.7 1.9 1 1 0 1 1 1 1 Stage V sporulation protein AD (SpoVAD) ACP_syn_III PF08545.10 CDW60804.1 - 0.0063 16.3 0.6 0.015 15.2 0.6 1.5 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Dodecin PF07311.12 CDW60804.1 - 0.035 14.4 2.0 0.67 10.2 0.1 2.7 2 1 0 2 2 2 0 Dodecin EIIBC-GUT_C PF07663.11 CDW60804.1 - 0.5 10.6 3.3 1.9 8.7 0.2 2.9 3 1 0 3 3 3 0 Sorbitol phosphotransferase enzyme II C-terminus CUB PF00431.20 CDW60805.1 - 2.5e-15 56.8 0.2 5.8e-11 42.7 0.1 2.2 2 0 0 2 2 2 2 CUB domain EGF PF00008.27 CDW60805.1 - 2.9e-06 27.5 5.0 7.3e-06 26.2 5.0 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_2 PF07974.13 CDW60805.1 - 0.0073 16.7 8.2 0.018 15.4 8.2 1.7 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 CDW60805.1 - 0.056 14.1 2.6 0.21 12.3 2.6 2.1 1 0 0 1 1 1 0 Human growth factor-like EGF DUF4371 PF14291.6 CDW60806.1 - 0.00029 20.6 0.0 0.00044 20.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) rve PF00665.26 CDW60807.1 - 1.4e-27 96.2 0.3 3.8e-27 94.8 0.0 1.9 3 0 0 3 3 3 1 Integrase core domain HTH_21 PF13276.6 CDW60807.1 - 3.6e-17 62.2 3.8 1.1e-16 60.7 3.8 1.9 1 0 0 1 1 1 1 HTH-like domain rve_3 PF13683.6 CDW60807.1 - 3e-12 46.1 0.2 9.4e-12 44.5 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain HTH_Tnp_1 PF01527.20 CDW60807.1 - 7.2e-07 29.4 1.6 1e-05 25.7 0.1 2.8 3 0 0 3 3 3 1 Transposase rve_2 PF13333.6 CDW60807.1 - 1.3e-06 28.5 0.0 2.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CDW60807.1 - 1.5e-05 25.2 0.0 2.9e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 DDE domain HTH_28 PF13518.6 CDW60807.1 - 0.036 14.2 0.9 3 8.0 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_Tnp_1_2 PF13022.6 CDW60807.1 - 0.042 14.0 0.1 0.46 10.6 0.0 2.6 2 1 0 2 2 2 0 Helix-turn-helix of insertion element transposase Sigma54_activ_2 PF14532.6 CDW60808.1 - 6.5e-15 55.5 0.0 1.1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Response_reg PF00072.24 CDW60808.1 - 1.2e-12 47.9 0.0 4.4e-12 46.2 0.0 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HTH_8 PF02954.19 CDW60808.1 - 1.1e-10 41.1 0.6 1.1e-10 41.1 0.6 2.1 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family Sigma54_activat PF00158.26 CDW60808.1 - 5e-07 29.6 0.0 0.00017 21.3 0.0 2.8 1 1 1 2 2 2 2 Sigma-54 interaction domain HTH_17 PF12728.7 CDW60808.1 - 0.061 13.5 0.0 0.3 11.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HATPase_c PF02518.26 CDW60809.1 - 3.7e-14 53.2 0.0 1.3e-13 51.4 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 CDW60809.1 - 9.6e-07 28.8 0.2 9.6e-07 28.8 0.2 4.2 4 1 0 4 4 4 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CDW60809.1 - 3.2e-05 24.2 2.1 0.00011 22.5 0.1 3.1 3 0 0 3 3 3 1 HAMP domain HATPase_c_3 PF13589.6 CDW60809.1 - 0.05 13.4 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SOAR PF16533.5 CDW60809.1 - 3.8 7.5 7.8 0.77 9.8 0.2 3.1 3 0 0 3 3 3 0 STIM1 Orai1-activating region MnmE_helical PF12631.7 CDW60809.1 - 6 7.0 8.1 1.6 8.8 1.1 2.6 2 1 0 2 2 2 0 MnmE helical domain SBP_bac_6 PF13343.6 CDW60810.1 - 1.1e-29 103.6 0.0 1.7e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 CDW60810.1 - 6.4e-16 58.8 0.1 1.1e-15 58.1 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_8 PF13416.6 CDW60810.1 - 4.2e-08 33.3 0.0 6.3e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 CDW60810.1 - 6.5e-05 23.0 0.0 0.00027 21.0 0.0 2.0 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein MutS_III PF05192.18 CDW60810.1 - 0.04 14.1 0.1 0.056 13.7 0.1 1.2 1 0 0 1 1 1 0 MutS domain III SAC3_GANP PF03399.16 CDW60811.1 - 1.6e-25 90.1 7.8 1.1e-23 84.0 7.8 2.0 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CDW60811.1 - 0.00093 19.2 1.0 0.0019 18.2 0.2 1.9 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family DUF1759 PF03564.15 CDW60812.1 - 0.0017 18.3 0.3 0.14 12.0 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1759) Kringle PF00051.18 CDW60813.1 - 3.7e-09 36.8 10.6 1.6e-07 31.5 3.1 3.4 3 0 0 3 3 3 2 Kringle domain Fer4_3 PF12798.7 CDW60813.1 - 7.5 7.7 9.5 0.9 10.6 0.3 3.5 3 0 0 3 3 3 0 4Fe-4S binding domain DIE2_ALG10 PF04922.12 CDW60815.1 - 2.2e-57 195.2 6.5 2.8e-57 194.8 6.5 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family Hum_adeno_E3A PF05393.11 CDW60815.1 - 0.031 14.2 0.5 0.065 13.2 0.5 1.6 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein zf-C2H2_4 PF13894.6 CDW60819.1 - 0.00099 19.8 11.8 0.13 13.2 0.1 3.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 CDW60819.1 - 0.0012 19.2 11.5 0.032 14.7 0.1 4.4 4 0 0 4 4 4 2 Zinc finger, C2H2 type HypA PF01155.19 CDW60819.1 - 0.0025 17.8 3.2 2.7 8.1 0.5 3.0 1 1 2 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_ZHX PF18387.1 CDW60819.1 - 0.023 14.3 2.6 0.73 9.5 0.1 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_2 PF13465.6 CDW60819.1 - 0.053 14.0 11.9 2 9.0 1.1 4.0 4 0 0 4 4 4 0 Zinc-finger double domain DUF2197 PF09963.9 CDW60819.1 - 0.066 13.5 0.1 1.7 9.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) DDE_Tnp_1_6 PF13751.6 CDW60819.1 - 0.2 11.9 2.2 0.39 10.9 2.2 1.7 1 1 0 1 1 1 0 Transposase DDE domain IBR PF01485.21 CDW60819.1 - 0.2 11.9 7.2 1.1 9.5 1.1 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain CpXC PF14353.6 CDW60819.1 - 0.21 11.6 3.6 1.3 9.1 0.0 2.6 2 1 1 3 3 3 0 CpXC protein Rhodanese_C PF12368.8 CDW60819.1 - 0.28 11.6 3.7 5.8 7.4 4.6 2.2 1 1 1 2 2 2 0 Rhodanase C-terminal zf_UBZ PF18439.1 CDW60819.1 - 0.54 9.9 7.1 18 5.0 0.0 3.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C3HC4_3 PF13920.6 CDW60819.1 - 1.9 8.4 9.0 20 5.1 2.5 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 CDW60819.1 - 2.3 8.3 6.9 2.6e+02 1.8 6.9 2.8 1 1 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 CDW60819.1 - 4.4 7.4 8.0 1.8 8.6 0.8 2.9 2 1 1 3 3 3 0 Transposase zinc-ribbon domain Robl_LC7 PF03259.17 CDW60821.1 - 8.6e-12 44.7 0.0 1.1e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain LSM PF01423.22 CDW60822.1 - 5.8e-21 74.0 0.0 7.1e-21 73.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDW60822.1 - 0.0046 17.1 0.0 0.0052 16.9 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain CspB_prodomain PF18425.1 CDW60822.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Csp protease B prodomain rve PF00665.26 CDW60823.1 - 1.5e-07 31.6 0.0 3.1e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 CDW60823.1 - 0.00022 21.2 0.2 0.00057 19.9 0.2 1.7 1 1 0 1 1 1 1 Integrase zinc binding domain Prok-RING_2 PF14445.6 CDW60823.1 - 0.094 12.9 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 DUF4733 PF15878.5 CDW60824.1 - 0.17 12.4 0.0 0.39 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4733) NADHdh PF00146.21 CDW60826.1 - 1.7e-16 60.4 11.3 8.7e-09 35.1 3.5 3.0 1 1 1 2 2 2 2 NADH dehydrogenase PRT_C PF08372.10 CDW60826.1 - 2 8.1 6.4 0.53 10.0 1.4 2.2 2 1 1 3 3 3 0 Plant phosphoribosyltransferase C-terminal SDF PF00375.18 CDW60827.1 - 4.5e-105 351.9 33.4 5.5e-105 351.6 33.4 1.1 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Vma12 PF11712.8 CDW60827.1 - 3.1 7.9 6.9 0.11 12.5 0.5 1.9 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Catalase PF00199.19 CDW60828.1 - 6e-178 591.8 0.0 7.5e-178 591.5 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CDW60828.1 - 1.8e-17 63.3 0.0 4.2e-17 62.1 0.0 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 CDW60828.1 - 6.1e-15 55.2 0.1 9.7e-15 54.5 0.1 1.3 1 0 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 CDW60828.1 - 0.00044 20.1 0.1 0.00075 19.3 0.1 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family YdjC PF04794.12 CDW60829.1 - 1e-57 195.8 0.0 1.2e-57 195.6 0.0 1.0 1 0 0 1 1 1 1 YdjC-like protein DUF229 PF02995.17 CDW60831.1 - 2.6e-101 339.7 0.0 5.7e-101 338.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF229) Integrase_H2C2 PF17921.1 CDW60832.1 - 8.7e-20 70.6 1.7 1.3e-19 70.0 1.7 1.3 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDW60832.1 - 5.5e-05 23.3 0.6 0.00013 22.1 0.6 1.7 1 0 0 1 1 1 1 H2C2 zinc finger CM_1 PF07736.11 CDW60832.1 - 0.062 13.7 0.2 0.1 13.0 0.2 1.3 1 0 0 1 1 1 0 Chorismate mutase type I AMP-binding PF00501.28 CDW60833.1 - 1.2e-24 86.7 0.0 1.6e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CDW60833.1 - 4.5e-17 61.7 2.2 6.8e-17 61.1 2.2 1.3 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Cmyb_C PF09316.10 CDW60834.1 - 2.5e-05 24.0 0.0 4.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 C-myb, C-terminal Peptidase_S24 PF00717.23 CDW60835.1 - 3.8e-18 65.2 0.2 6.2e-18 64.5 0.2 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CDW60835.1 - 1.6e-07 31.2 0.0 5.5e-07 29.4 0.0 1.9 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Aminotran_5 PF00266.19 CDW60836.1 - 3.9e-80 269.6 0.0 4.9e-80 269.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Pribosyltran PF00156.27 CDW60836.1 - 1.3e-10 41.1 0.2 2.3e-10 40.2 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 CDW60836.1 - 1.8e-08 34.6 0.3 7.1e-07 29.4 0.0 2.2 1 1 1 2 2 2 1 Phosphoribosyl synthetase-associated domain Cor1 PF04803.12 CDW60836.1 - 0.0006 20.0 0.3 0.0015 18.8 0.0 1.7 2 0 0 2 2 2 1 Cor1/Xlr/Xmr conserved region GAD-like PF08887.11 CDW60836.1 - 0.1 12.4 0.0 0.26 11.1 0.0 1.7 1 0 0 1 1 1 0 GAD-like domain polyprenyl_synt PF00348.17 CDW60837.1 - 1.6e-64 217.4 0.3 2.1e-64 217.0 0.3 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 CDW60837.1 - 0.08 12.3 0.0 8.4 5.7 0.0 2.4 2 0 0 2 2 2 0 Terpene synthase family, metal binding domain Pyr_redox_2 PF07992.14 CDW60838.1 - 6.4e-36 124.1 0.3 9.5e-36 123.5 0.3 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Hpre_diP_synt_I PF07456.11 CDW60838.1 - 4.6e-26 91.6 7.8 4.6e-26 91.6 7.8 2.3 3 0 0 3 3 3 1 Heptaprenyl diphosphate synthase component I NusG_II PF07009.11 CDW60838.1 - 1.5e-22 79.8 0.0 3.5e-22 78.6 0.0 1.6 1 0 0 1 1 1 1 NusG domain II Pyr_redox PF00070.27 CDW60838.1 - 0.00014 22.3 0.4 0.0006 20.3 0.1 2.3 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DoxD PF04173.13 CDW60838.1 - 0.00036 20.5 5.0 0.069 13.0 2.8 3.0 2 0 0 2 2 2 2 TQO small subunit DoxD DoxX PF07681.12 CDW60838.1 - 0.015 15.9 4.6 0.015 15.9 4.6 3.2 2 1 0 3 3 3 0 DoxX DUF903 PF06004.12 CDW60838.1 - 0.11 12.5 0.6 0.81 9.6 0.3 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF903) CBM60 PF16841.5 CDW60838.1 - 0.83 10.1 2.5 3 8.3 0.0 2.7 3 0 0 3 3 3 0 Ca-dependent carbohydrate-binding module xylan-binding FMN_bind PF04205.14 CDW60839.1 - 3.6e-11 43.5 7.8 2.4e-05 24.8 0.1 3.3 3 0 0 3 3 3 2 FMN-binding domain SMODS PF18144.1 CDW60839.1 - 0.0044 17.2 1.6 1.3 9.1 0.2 2.4 2 0 0 2 2 2 2 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Lysis_col PF02402.16 CDW60839.1 - 0.029 14.0 0.1 0.056 13.1 0.1 1.5 1 0 0 1 1 1 0 Lysis protein Molybdopterin_N PF18364.1 CDW60839.1 - 0.1 12.6 0.0 4.9 7.2 0.0 2.7 2 0 0 2 2 2 0 Molybdopterin oxidoreductase N-terminal domain LPAM_2 PF13627.6 CDW60839.1 - 0.95 9.4 3.4 1.5 8.8 3.4 1.3 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site Cytochrom_C_2 PF01322.20 CDW60839.1 - 1.3 9.9 5.2 14 6.6 0.7 2.4 2 0 0 2 2 2 0 Cytochrome C' PepSY_2 PF13670.6 CDW60839.1 - 1.8 8.6 7.0 0.49 10.4 2.0 2.7 2 2 1 3 3 3 0 Peptidase propeptide and YPEB domain Phosphoprotein PF00922.17 CDW60839.1 - 5 6.7 9.7 2.7 7.6 2.7 2.2 1 1 1 2 2 2 0 Vesiculovirus phosphoprotein Phi29_Phage_SSB PF17427.2 CDW60844.1 - 0.0022 18.2 0.0 0.0025 18.0 0.0 1.1 1 0 0 1 1 1 1 Phage Single-stranded DNA-binding protein DNA_pol_B_2 PF03175.13 CDW60845.1 - 1.1e-39 136.7 15.7 5.1e-31 108.0 7.0 2.8 1 1 1 2 2 2 2 DNA polymerase type B, organellar and viral ATP-synt_C PF00137.21 CDW60846.1 - 6.3e-11 42.4 7.8 7.1e-11 42.3 7.8 1.0 1 0 0 1 1 1 1 ATP synthase subunit C DUF229 PF02995.17 CDW60847.1 - 5.5e-115 384.8 0.0 6.9e-115 384.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 CDW60847.1 - 0.1 12.0 0.0 0.33 10.3 0.0 1.7 1 1 0 1 1 1 0 Sulfatase hemP PF10636.9 CDW60847.1 - 0.12 12.3 0.9 3.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Hemin uptake protein hemP Kunitz_BPTI PF00014.23 CDW60848.1 - 6.4e-27 93.6 12.6 9e-15 54.6 8.8 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 CDW60848.1 - 3.6e-06 27.3 12.3 3.6e-06 27.3 12.3 2.9 3 0 0 3 3 3 1 Lustrin, cysteine-rich repeated domain Kunitz_BPTI PF00014.23 CDW60849.1 - 5.7e-15 55.3 7.6 2.1e-09 37.5 3.7 2.4 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain FtsK_SpoIIIE PF01580.18 CDW60850.1 - 1e-76 257.5 0.1 1.6e-76 256.9 0.1 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family FtsK_alpha PF17854.1 CDW60850.1 - 4.1e-29 100.7 0.0 7.9e-29 99.8 0.0 1.5 1 0 0 1 1 1 1 FtsK alpha domain FtsK_gamma PF09397.10 CDW60850.1 - 1e-28 98.9 0.1 2e-28 97.9 0.1 1.5 1 0 0 1 1 1 1 Ftsk gamma domain FtsK_4TM PF13491.6 CDW60850.1 - 1.5e-11 44.3 5.9 2.1e-11 43.8 5.9 1.2 1 0 0 1 1 1 1 4TM region of DNA translocase FtsK/SpoIIIE AAA_10 PF12846.7 CDW60850.1 - 2.1e-05 23.6 0.0 0.0044 16.0 0.0 2.2 2 0 0 2 2 2 2 AAA-like domain DUF87 PF01935.17 CDW60850.1 - 0.00048 20.3 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 Helicase HerA, central domain T2SSE PF00437.20 CDW60850.1 - 0.015 14.4 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 CDW60850.1 - 0.016 14.1 0.0 0.19 10.6 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Na_H_antiporter PF03553.14 CDW60850.1 - 0.099 11.9 2.0 0.17 11.1 2.0 1.2 1 0 0 1 1 1 0 Na+/H+ antiporter family Adeno_IVa2 PF02456.15 CDW60850.1 - 0.15 10.9 0.0 0.26 10.1 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein TniB PF05621.11 CDW60850.1 - 0.16 11.4 0.0 15 4.9 0.0 3.1 3 0 0 3 3 3 0 Bacterial TniB protein LolA PF03548.15 CDW60851.1 - 1e-58 197.7 4.1 1.2e-58 197.5 4.1 1.0 1 0 0 1 1 1 1 Outer membrane lipoprotein carrier protein LolA DUF1964 PF09244.10 CDW60851.1 - 0.0019 18.6 0.7 0.066 13.7 0.1 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1964) DUF3220 PF11516.8 CDW60851.1 - 0.058 13.6 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) DUF5024 PF16427.5 CDW60851.1 - 0.058 13.7 0.2 0.15 12.4 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5024) MgsA_C PF12002.8 CDW60852.1 - 1.5e-64 217.0 0.8 2.9e-64 216.0 0.8 1.5 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 CDW60852.1 - 1.3e-23 83.1 0.3 4.9e-23 81.3 0.1 2.1 2 0 0 2 2 1 1 AAA C-terminal domain AAA PF00004.29 CDW60852.1 - 2.6e-18 66.7 0.1 2.5e-17 63.5 0.0 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDW60852.1 - 3.5e-15 56.1 0.0 1.3e-14 54.3 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDW60852.1 - 1.1e-07 31.9 0.1 1.9e-06 27.9 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW60852.1 - 2.2e-07 31.4 0.6 0.0011 19.4 0.0 3.3 1 1 3 4 4 4 2 AAA ATPase domain Mg_chelatase PF01078.21 CDW60852.1 - 3.9e-07 29.7 0.5 0.0011 18.4 0.1 2.6 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CDW60852.1 - 5.2e-06 26.3 0.0 0.009 15.7 0.0 2.3 1 1 1 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 CDW60852.1 - 7.9e-06 26.2 0.9 0.046 14.0 0.0 3.1 1 1 2 3 3 3 2 AAA domain AAA_3 PF07726.11 CDW60852.1 - 7.3e-05 22.6 0.0 0.00045 20.1 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 CDW60852.1 - 7.3e-05 22.6 0.5 0.0026 17.5 0.5 2.5 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CDW60852.1 - 0.00011 22.5 0.0 0.032 14.6 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 CDW60852.1 - 0.00014 22.0 0.0 0.00072 19.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 CDW60852.1 - 0.00024 21.4 0.0 0.13 12.7 0.0 2.4 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 CDW60852.1 - 0.00028 20.9 0.0 0.00071 19.6 0.0 1.6 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 CDW60852.1 - 0.0004 20.2 0.0 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.15 CDW60852.1 - 0.00062 19.8 0.2 0.68 9.9 0.1 2.6 2 1 1 3 3 2 1 Type III restriction enzyme, res subunit Sigma54_activ_2 PF14532.6 CDW60852.1 - 0.0014 18.8 0.0 0.0024 18.0 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain DNA_pol3_delta2 PF13177.6 CDW60852.1 - 0.0021 17.9 0.0 0.082 12.7 0.0 2.1 1 1 1 2 2 2 1 DNA polymerase III, delta subunit ABC_tran PF00005.27 CDW60852.1 - 0.0031 18.0 0.0 0.0054 17.2 0.0 1.5 1 1 0 1 1 1 1 ABC transporter ATP-synt_ab PF00006.25 CDW60852.1 - 0.0032 17.2 0.0 0.024 14.3 0.0 2.3 3 0 0 3 3 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA_28 PF13521.6 CDW60852.1 - 0.0042 17.3 0.1 0.028 14.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CDW60852.1 - 0.0049 16.6 0.0 0.0093 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CDW60852.1 - 0.0055 16.9 0.2 0.021 15.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDW60852.1 - 0.0068 15.6 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CDW60852.1 - 0.0093 16.5 0.0 0.02 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CDW60852.1 - 0.014 15.2 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CDW60852.1 - 0.03 14.3 0.0 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 CDW60852.1 - 0.041 13.5 0.2 0.13 11.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 CDW60852.1 - 0.051 12.6 0.0 0.1 11.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein TniB PF05621.11 CDW60852.1 - 0.058 12.8 0.0 1.4 8.3 0.0 2.8 1 1 2 3 3 3 0 Bacterial TniB protein DUF2075 PF09848.9 CDW60852.1 - 0.062 12.5 0.2 0.93 8.7 0.4 2.5 2 2 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Resolvase PF00239.21 CDW60852.1 - 0.071 13.2 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Resolvase, N terminal domain cobW PF02492.19 CDW60852.1 - 0.093 12.3 0.0 0.21 11.2 0.0 1.5 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 CDW60852.1 - 0.12 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 CDW60852.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 NTPase TIP49 PF06068.13 CDW60852.1 - 0.13 11.4 0.0 0.27 10.4 0.0 1.5 1 1 0 1 1 1 0 TIP49 P-loop domain AAA_17 PF13207.6 CDW60852.1 - 0.15 12.5 0.1 0.64 10.4 0.1 2.3 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CDW60852.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.5 1 1 0 1 1 1 0 RsgA GTPase ATPase_2 PF01637.18 CDW60852.1 - 0.17 11.8 0.1 4 7.3 0.1 2.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CDW60852.1 - 0.18 11.3 0.0 0.9 9.0 0.0 2.1 1 1 1 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 CDW60852.1 - 0.19 10.8 0.0 0.89 8.6 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 HSP70 PF00012.20 CDW60853.1 - 2.7e-173 577.4 7.6 3.2e-173 577.2 7.6 1.0 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.16 CDW60853.1 - 1.4e-05 25.0 0.2 3.1e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 CDW60853.1 - 0.00047 20.5 4.4 0.18 12.2 0.3 3.0 2 1 0 2 2 2 2 Cell division protein FtsA FIVAR PF07554.13 CDW60853.1 - 0.0088 16.8 3.3 0.51 11.1 0.2 2.6 1 1 1 2 2 2 2 FIVAR domain Ead_Ea22 PF13935.6 CDW60853.1 - 0.54 10.9 0.0 0.54 10.9 0.0 2.7 2 1 0 2 2 2 0 Ead/Ea22-like protein SPT6_acidic PF14632.6 CDW60855.1 - 5e-08 33.4 31.9 5e-08 33.4 31.9 2.2 1 1 1 2 2 2 1 Acidic N-terminal SPT6 MCM_bind PF09739.9 CDW60855.1 - 0.33 9.4 6.1 0.36 9.2 6.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Nop14 PF04147.12 CDW60855.1 - 5 5.2 30.0 5.5 5.1 30.0 1.0 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 CDW60855.1 - 5.1 5.1 36.3 7.1 4.6 36.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sec62 PF03839.16 CDW60855.1 - 7.8 5.9 6.5 9 5.7 6.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 SGT1 PF07093.11 CDW60855.1 - 9.8 4.5 17.7 12 4.2 17.7 1.1 1 0 0 1 1 1 0 SGT1 protein EF-hand_4 PF12763.7 CDW60856.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand PH PF00169.29 CDW60856.1 - 0.13 12.8 0.2 8.8 6.9 0.1 2.3 2 0 0 2 2 2 0 PH domain Hist_deacetyl PF00850.19 CDW60857.1 - 2.2e-21 76.6 1.1 2.4e-21 76.5 1.1 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Zn_Tnp_IS1595 PF12760.7 CDW60858.1 - 0.001 19.0 0.8 0.0017 18.3 0.8 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DNA_ligase_ZBD PF03119.16 CDW60858.1 - 0.014 15.4 1.4 0.037 14.0 1.4 1.7 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain IBR PF01485.21 CDW60858.1 - 0.032 14.5 0.4 0.055 13.7 0.4 1.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-NADH-PPase PF09297.11 CDW60858.1 - 0.05 13.3 4.4 0.1 12.2 4.4 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain His_Phos_1 PF00300.22 CDW60860.1 - 1.4e-24 86.9 0.0 1.6e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) HMG_box PF00505.19 CDW60862.1 - 1.9e-19 69.8 3.0 2.9e-19 69.3 3.0 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CDW60862.1 - 3.3e-09 37.2 1.5 4.9e-09 36.7 1.5 1.2 1 0 0 1 1 1 1 HMG-box domain tRNA-synt_2b PF00587.25 CDW60863.1 - 7.8e-52 175.8 0.0 1.6e-51 174.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Ribosomal_L20 PF00453.18 CDW60863.1 - 4.8e-47 158.5 9.4 4.8e-47 158.5 9.4 2.4 2 0 0 2 2 2 1 Ribosomal protein L20 IF3_C PF00707.22 CDW60863.1 - 2.1e-34 117.4 2.7 4e-34 116.4 0.9 2.4 2 0 0 2 2 2 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 CDW60863.1 - 5.1e-25 87.5 0.1 1.8e-24 85.8 0.1 2.1 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain HGTP_anticodon PF03129.20 CDW60863.1 - 3.9e-24 84.6 1.1 1.7e-23 82.6 1.1 2.2 1 0 0 1 1 1 1 Anticodon binding domain Ribosomal_L35p PF01632.19 CDW60863.1 - 2.4e-17 63.2 6.3 2.4e-17 63.2 6.3 2.6 2 0 0 2 2 2 1 Ribosomal protein L35 tRNA_SAD PF07973.14 CDW60863.1 - 3.6e-14 52.6 0.0 7.8e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 CDW60863.1 - 5.6e-14 51.9 0.2 1.4e-12 47.5 0.0 2.6 2 0 0 2 2 2 1 TGS domain SMC_ScpA PF02616.14 CDW60863.1 - 0.14 12.0 1.6 0.31 10.9 0.5 2.1 2 0 0 2 2 2 0 Segregation and condensation protein ScpA tRNA-synt_2d PF01409.20 CDW60864.1 - 2.5e-107 357.9 0.1 3e-107 357.6 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) Phe_tRNA-synt_N PF02912.18 CDW60864.1 - 1.2e-27 95.6 1.6 2.1e-27 94.8 1.1 1.7 2 0 0 2 2 2 1 Aminoacyl tRNA synthetase class II, N-terminal domain tRNA_synthFbeta PF17759.1 CDW60864.1 - 0.00031 20.2 0.0 0.0022 17.5 0.0 2.2 2 1 1 3 3 3 1 Phenylalanyl tRNA synthetase beta chain CLM domain FAD-oxidase_C PF02913.19 CDW60864.1 - 0.065 12.8 0.2 0.49 10.0 0.1 2.0 1 1 1 2 2 2 0 FAD linked oxidases, C-terminal domain tRNA_bind PF01588.20 CDW60865.1 - 4.6e-29 100.4 0.1 6.9e-29 99.8 0.1 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain Integrase_1 PF12835.7 CDW60866.1 - 1.7e-55 187.3 0.7 1.7e-55 187.3 0.7 2.0 2 1 1 3 3 3 1 Integrase Phage_int_SAM_2 PF12834.7 CDW60866.1 - 2.3e-37 127.6 2.3 5.2e-37 126.4 2.3 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal Phage_integrase PF00589.22 CDW60866.1 - 0.0012 18.7 1.1 0.0028 17.5 0.2 2.1 2 1 0 2 2 2 1 Phage integrase family Phage_int_SAM_1 PF02899.17 CDW60866.1 - 0.018 15.3 2.1 0.032 14.5 0.3 2.4 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain RHS_repeat PF05593.14 CDW60868.1 - 1.4e-50 169.2 63.1 4.9e-09 36.5 1.1 12.7 10 1 1 12 12 12 12 RHS Repeat PAAR_motif PF05488.13 CDW60868.1 - 0.031 14.5 0.1 0.084 13.1 0.1 1.8 1 0 0 1 1 1 0 PAAR motif UBN_AB PF14075.6 CDW60869.1 - 2.4e-22 79.7 0.3 1e-21 77.6 0.3 2.1 1 1 0 1 1 1 1 Ubinuclein conserved middle domain HUN PF08729.10 CDW60869.1 - 5.5e-19 67.9 0.4 1.1e-18 67.0 0.4 1.4 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Solute_trans_a PF03619.16 CDW60871.1 - 2.4e-38 132.2 6.2 3.8e-38 131.5 6.2 1.3 1 0 0 1 1 1 1 Organic solute transporter Ostalpha SLATT_5 PF18160.1 CDW60871.1 - 0.0051 16.1 1.4 0.0074 15.6 0.0 1.8 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain family 5 FtsX PF02687.21 CDW60872.1 - 0.012 16.0 0.3 0.02 15.4 0.3 1.4 1 0 0 1 1 1 0 FtsX-like permease family FixQ PF05545.11 CDW60872.1 - 0.033 14.2 2.6 0.073 13.0 2.6 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ SUI1 PF01253.22 CDW60873.1 - 2.6e-17 63.1 0.0 5.4e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Phosphodiest PF01663.22 CDW60878.1 - 2.2e-11 43.9 0.2 3.8e-11 43.2 0.1 1.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 CDW60878.1 - 0.11 11.8 0.1 0.19 11.0 0.1 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily Prenyltransf PF01255.19 CDW60879.1 - 4e-05 23.2 0.0 0.13 11.7 0.0 2.1 2 0 0 2 2 2 2 Putative undecaprenyl diphosphate synthase NAD_kinase PF01513.21 CDW60880.1 - 0.015 14.5 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 ATP-NAD kinase CAMSAP_CKK PF08683.11 CDW60883.1 - 5e-05 23.4 5.5 11 6.2 0.0 5.8 5 1 3 8 8 8 2 Microtubule-binding calmodulin-regulated spectrin-associated DUF3926 PF13080.6 CDW60883.1 - 0.00074 19.4 0.0 1.1e+02 2.8 0.0 5.5 6 0 0 6 6 6 0 Protein of unknown function (DUF3926) Stevor PF17410.2 CDW60883.1 - 0.00092 18.8 0.9 81 2.6 0.0 5.2 6 0 0 6 6 6 0 Subtelomeric Variable Open Reading frame Flavodoxin_5 PF12724.7 CDW60883.1 - 0.002 18.4 0.0 1.2e+02 2.8 0.0 5.4 6 0 0 6 6 6 0 Flavodoxin domain ETF_alpha PF00766.19 CDW60883.1 - 0.0028 17.7 6.1 93 3.2 0.0 5.4 5 0 0 5 5 5 0 Electron transfer flavoprotein FAD-binding domain NatB_MDM20 PF09797.9 CDW60884.1 - 2.2e-29 102.6 0.7 2.7e-29 102.3 0.7 1.1 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit Herpes_UL49_2 PF04823.12 CDW60884.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL49 tegument protein ARPC4 PF05856.12 CDW60885.1 - 6.9e-13 48.5 0.3 1.1e-12 47.9 0.3 1.3 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) CRAL_TRIO PF00650.20 CDW60887.1 - 5e-08 32.8 0.0 7.6e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain DUF4604 PF15377.6 CDW60888.1 - 9.7e-15 55.4 1.3 1e-14 55.3 1.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) DUF1759 PF03564.15 CDW60889.1 - 4.7e-24 85.0 0.2 1.4e-23 83.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 CDW60889.1 - 5.8e-16 58.7 0.0 9.6e-16 58.0 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase (DUF1758) DUF2015 PF09435.10 CDW60889.1 - 0.069 13.0 0.0 0.47 10.3 0.0 2.3 2 1 0 2 2 2 0 Fungal protein of unknown function (DUF2015) DUF5304 PF17230.2 CDW60889.1 - 2.5 8.3 5.6 1.3 9.2 0.2 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5304) APG9 PF04109.16 CDW60890.1 - 9.7e-34 117.2 0.2 1.2e-33 116.9 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 DUF5641 PF18701.1 CDW60891.1 - 9.9e-14 51.3 0.0 1.3e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5641) HAS-barrel PF09378.10 CDW60891.1 - 0.054 13.7 0.0 0.071 13.3 0.0 1.3 1 0 0 1 1 1 0 HAS barrel domain Histone PF00125.24 CDW60892.1 - 3.8e-50 169.6 4.5 4.2e-50 169.5 4.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW60892.1 - 4.3e-05 24.1 1.1 5.1e-05 23.9 1.1 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW60892.1 - 8.6e-05 22.6 0.1 8.6e-05 22.6 0.1 1.8 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW60892.1 - 0.0017 18.7 0.1 0.0027 18.0 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW60892.1 - 0.013 15.5 0.1 0.032 14.3 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW60892.1 - 0.058 13.7 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1759 PF03564.15 CDW60893.1 - 0.019 14.9 0.0 0.045 13.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) Pkinase PF00069.25 CDW60894.1 - 2.1e-10 40.5 0.0 2.2e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW60894.1 - 1e-08 34.8 0.0 1.2e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ANF_receptor PF01094.28 CDW60896.1 - 1.5e-22 80.2 0.5 3.3e-22 79.1 0.1 1.6 2 0 0 2 2 2 1 Receptor family ligand binding region 7tm_3 PF00003.22 CDW60896.1 - 9.5e-11 41.9 7.6 1.9e-10 40.9 7.6 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF2207 PF09972.9 CDW60896.1 - 0.059 12.1 0.1 0.074 11.8 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_2_3 PF16080.5 CDW60896.1 - 0.2 11.4 2.7 0.98 9.2 0.4 2.5 2 0 0 2 2 2 0 Bacteriophage holin family HP1 PrmA PF06325.13 CDW60897.1 - 2.4e-105 352.2 1.3 2.7e-105 352.0 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CDW60897.1 - 5.2e-14 52.1 0.4 1e-13 51.2 0.4 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CDW60897.1 - 3.7e-09 36.5 0.1 7.7e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CDW60897.1 - 1.1e-08 35.6 0.1 2.1e-08 34.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CDW60897.1 - 2.3e-07 30.8 0.2 3.5e-07 30.3 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CDW60897.1 - 3.8e-06 27.4 0.0 7.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CDW60897.1 - 4.7e-06 26.5 0.0 6.6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 CDW60897.1 - 7.3e-06 25.9 0.0 2e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CDW60897.1 - 0.00027 21.6 0.2 0.00048 20.8 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CDW60897.1 - 0.00039 20.2 0.8 0.00072 19.3 0.8 1.3 1 0 0 1 1 1 1 Lysine methyltransferase GCD14 PF08704.10 CDW60897.1 - 0.00058 19.6 0.0 0.00084 19.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 CDW60897.1 - 0.00074 19.3 0.1 0.0011 18.7 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TRM PF02005.16 CDW60897.1 - 0.00089 18.5 0.0 0.0012 18.1 0.0 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Cons_hypoth95 PF03602.15 CDW60897.1 - 0.0017 18.0 0.1 0.0041 16.8 0.0 1.6 2 0 0 2 2 2 1 Conserved hypothetical protein 95 CMAS PF02353.20 CDW60897.1 - 0.002 17.5 0.2 0.0046 16.3 0.2 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 CDW60897.1 - 0.013 14.9 0.1 0.022 14.2 0.1 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB NNMT_PNMT_TEMT PF01234.17 CDW60897.1 - 0.042 13.0 0.0 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family FtsJ PF01728.19 CDW60897.1 - 0.052 13.6 0.1 0.38 10.9 0.1 2.0 1 1 0 1 1 1 0 FtsJ-like methyltransferase UPF0020 PF01170.18 CDW60897.1 - 0.069 12.8 0.2 0.17 11.5 0.2 1.7 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 GidB PF02527.15 CDW60897.1 - 0.15 11.4 0.3 0.42 9.9 0.3 1.6 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G DUF3013 PF11217.8 CDW60898.1 - 3e-51 173.4 3.5 4.4e-51 172.9 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3013) Pur_DNA_glyco PF02245.16 CDW60898.1 - 8.7e-35 119.7 0.0 1.3e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) MgsA_C PF12002.8 CDW60899.1 - 1.1e-64 217.4 0.3 2.6e-64 216.2 0.3 1.6 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 CDW60899.1 - 1.8e-26 92.3 0.1 1.8e-26 92.3 0.1 2.6 4 0 0 4 4 2 1 AAA C-terminal domain AAA PF00004.29 CDW60899.1 - 2e-16 60.6 0.0 3.6e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CDW60899.1 - 1.6e-14 53.9 0.1 2.6e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CDW60899.1 - 7.3e-07 29.3 0.2 6.5e-05 23.0 0.1 2.9 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CDW60899.1 - 9.3e-07 28.7 0.1 0.0041 16.8 0.0 2.3 1 1 1 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 CDW60899.1 - 1.2e-05 25.7 0.7 0.0099 16.3 0.0 2.6 1 1 1 2 2 2 2 AAA ATPase domain TIP49 PF06068.13 CDW60899.1 - 3.6e-05 23.1 0.4 0.00016 21.0 0.1 1.9 1 1 1 2 2 2 1 TIP49 P-loop domain AAA_14 PF13173.6 CDW60899.1 - 0.00022 21.3 0.0 0.00041 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CDW60899.1 - 0.00028 20.3 0.2 0.059 12.7 0.1 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 CDW60899.1 - 0.00031 21.3 0.0 0.0011 19.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CDW60899.1 - 0.00033 20.9 1.2 0.55 10.5 0.1 2.5 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 CDW60899.1 - 0.001 19.4 0.8 0.9 9.9 0.1 2.4 1 1 1 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.6 CDW60899.1 - 0.0016 18.5 0.0 0.0028 17.8 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Parvo_NS1 PF01057.17 CDW60899.1 - 0.0018 17.4 0.0 0.0029 16.7 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 DNA_pol3_delta2 PF13177.6 CDW60899.1 - 0.0089 15.8 0.1 0.31 10.8 0.1 2.3 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_24 PF13479.6 CDW60899.1 - 0.0093 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CDW60899.1 - 0.014 15.2 0.2 0.039 13.7 0.2 1.8 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 CDW60899.1 - 0.042 13.6 2.0 0.11 12.2 0.3 2.5 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CDW60899.1 - 0.051 13.4 0.0 0.5 10.2 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CDW60899.1 - 0.056 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CDW60899.1 - 0.07 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CDW60899.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 CDW60899.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CDW60899.1 - 0.19 11.2 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 CDW60899.1 - 0.2 11.0 0.6 8.7 5.7 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein Usp PF00582.26 CDW60900.1 - 1.9e-38 132.2 0.3 2.1e-38 132.0 0.3 1.0 1 0 0 1 1 1 1 Universal stress protein family Motile_Sperm PF00635.26 CDW60901.1 - 1.5e-09 37.6 0.0 2.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain MFS_1 PF07690.16 CDW60902.1 - 4.7e-25 88.3 30.5 4.7e-25 88.3 30.5 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CDW60902.1 - 2.7e-07 29.8 20.2 2.7e-07 29.8 20.2 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 CDW60902.1 - 0.00011 20.6 16.2 0.00013 20.4 2.3 3.7 2 2 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 CDW60902.1 - 0.059 11.9 18.0 0.14 10.7 9.1 2.8 1 1 0 2 2 2 0 MFS/sugar transport protein DUF1072 PF06380.11 CDW60902.1 - 0.08 12.8 5.7 2.1 8.3 1.3 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1072) An_peroxidase PF03098.15 CDW60903.1 - 4.3e-91 306.1 0.0 8.1e-91 305.2 0.0 1.4 1 1 0 1 1 1 1 Animal haem peroxidase Lon_C PF05362.13 CDW60904.1 - 1.7e-10 40.8 0.0 2.7e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain FabA PF07977.13 CDW60905.1 - 3.8e-54 182.0 0.0 4.5e-54 181.8 0.0 1.1 1 0 0 1 1 1 1 FabA-like domain PqiA PF04403.13 CDW60906.1 - 1.2e-70 236.3 26.1 4.8e-43 146.7 9.5 2.6 2 1 0 2 2 2 2 Paraquat-inducible protein A ABC_trans_aux PF03886.13 CDW60906.1 - 3e-37 127.7 3.4 6.5e-37 126.6 3.4 1.6 1 0 0 1 1 1 1 ABC-type transport auxiliary lipoprotein component MlaD PF02470.20 CDW60906.1 - 7.2e-36 122.4 0.5 3.6e-14 52.8 0.0 3.4 3 0 0 3 3 3 3 MlaD protein DASH_Duo1 PF08651.10 CDW60906.1 - 0.0036 17.0 4.0 0.004 16.9 1.1 2.4 2 1 0 2 2 2 1 DASH complex subunit Duo1 DUF948 PF06103.11 CDW60906.1 - 0.0037 17.5 0.8 0.013 15.7 0.7 2.1 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) DHC_N2 PF08393.13 CDW60906.1 - 0.0091 15.1 2.1 0.014 14.6 2.1 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 DUF445 PF04286.12 CDW60906.1 - 0.015 15.2 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DZR PF12773.7 CDW60906.1 - 0.016 15.2 9.1 0.32 11.0 1.7 2.3 2 0 0 2 2 2 0 Double zinc ribbon DHR10 PF18595.1 CDW60906.1 - 0.019 15.0 1.6 0.039 14.0 1.6 1.4 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Rx_N PF18052.1 CDW60906.1 - 0.033 14.5 3.2 0.58 10.5 0.5 2.4 1 1 1 2 2 2 0 Rx N-terminal domain MapZ_EC1 PF18041.1 CDW60906.1 - 0.13 12.5 1.5 0.45 10.8 1.1 2.0 2 0 0 2 2 2 0 MapZ extracellular domain 1 Tmemb_55A PF09788.9 CDW60906.1 - 0.22 10.6 0.7 0.38 9.8 0.2 1.6 2 0 0 2 2 2 0 Transmembrane protein 55A HAUS5 PF14817.6 CDW60906.1 - 0.22 10.2 3.4 0.32 9.7 3.4 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 BAR PF03114.18 CDW60906.1 - 0.24 11.0 1.6 0.41 10.3 1.6 1.3 1 0 0 1 1 1 0 BAR domain zinc_ribbon_4 PF13717.6 CDW60906.1 - 0.46 10.4 3.2 3.3 7.7 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Mu-like_Com PF10122.9 CDW60906.1 - 0.61 9.6 3.0 4.8 6.7 0.5 2.5 2 0 0 2 2 2 0 Mu-like prophage protein Com zinc_ribbon_9 PF14369.6 CDW60906.1 - 1.6 9.0 7.4 1.1 9.5 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon zinc-ribbons_6 PF07191.12 CDW60906.1 - 4.3 7.4 8.4 3.8 7.6 1.6 2.3 2 0 0 2 2 2 0 zinc-ribbons DUF4795 PF16043.5 CDW60906.1 - 4.9 6.7 8.2 4.1 6.9 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Flagellin_N PF00669.20 CDW60906.1 - 7.9 6.6 10.0 21 5.2 5.0 2.6 2 1 1 3 3 2 0 Bacterial flagellin N-terminal helical region SLX9 PF15341.6 CDW60906.1 - 9.1 6.7 6.0 77 3.7 6.0 1.9 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 DUF5305 PF17231.2 CDW60909.1 - 0.031 13.7 0.2 0.041 13.3 0.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Glycophorin_A PF01102.18 CDW60909.1 - 0.042 14.1 0.0 0.066 13.5 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A SARAF PF06682.12 CDW60909.1 - 0.05 13.2 0.1 0.09 12.4 0.0 1.4 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Orf78 PF06024.12 CDW60909.1 - 0.12 12.6 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) HAD_2 PF13419.6 CDW60912.1 - 0.014 15.4 1.1 1.8 8.6 0.0 2.3 1 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CDW60912.1 - 0.038 14.3 0.4 2.7 8.2 0.0 2.4 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CDW60912.1 - 0.11 12.6 0.4 0.3 11.2 0.4 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase PAS_7 PF12860.7 CDW60914.1 - 0.064 13.4 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 PAS fold Mnd1 PF03962.15 CDW60914.1 - 0.14 12.4 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Mnd1 HTH domain Glyco_hydro_99 PF16317.5 CDW60915.1 - 2.6e-137 457.6 8.7 3.8e-137 457.0 8.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 PRCC PF10253.9 CDW60915.1 - 1.2e-07 32.8 0.0 2e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting Glyco_tran_WbsX PF14307.6 CDW60915.1 - 6.1e-05 22.6 0.1 0.023 14.1 0.0 3.0 3 1 1 4 4 4 2 Glycosyltransferase WbsX TMEM132 PF16070.5 CDW60916.1 - 1.3e-40 139.8 0.2 1.7e-40 139.5 0.2 1.1 1 0 0 1 1 1 1 Transmembrane protein family 132 RVT_3 PF13456.6 CDW60917.1 - 0.064 13.1 3.4 1 9.2 3.4 2.1 1 1 0 1 1 1 0 Reverse transcriptase-like ASCH PF04266.14 CDW60919.1 - 3.1e-16 59.9 0.0 6e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 ASCH domain zf-C2HC5 PF06221.13 CDW60919.1 - 3.3e-09 36.6 11.6 6e-09 35.8 11.6 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Ribos_L4_asso_C PF14374.6 CDW60919.1 - 2.4 8.3 5.6 13 5.9 1.3 2.8 3 0 0 3 3 3 0 60S ribosomal protein L4 C-terminal domain DUF1759 PF03564.15 CDW60920.1 - 0.0033 17.4 0.6 2.3 8.2 0.0 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF1759) eIF3g PF12353.8 CDW60920.1 - 0.0061 17.0 0.5 0.5 10.8 0.0 2.5 2 0 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit G DUF229 PF02995.17 CDW60921.1 - 7.9e-113 377.7 0.1 9.9e-113 377.4 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) RabGAP-TBC PF00566.18 CDW60922.1 - 6.4e-46 156.7 10.1 8.9e-46 156.2 10.1 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Hist_deacetyl PF00850.19 CDW60923.1 - 3.4e-41 141.7 0.4 8.1e-41 140.5 0.4 1.5 1 1 0 1 1 1 1 Histone deacetylase domain O-FucT PF10250.9 CDW60924.1 - 1.4e-33 117.0 0.1 1.8e-33 116.7 0.1 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase TPR_1 PF00515.28 CDW60925.1 - 8.7e-11 41.2 4.2 0.00043 20.0 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CDW60925.1 - 7.6e-10 38.3 0.4 3.1e-07 30.0 0.0 3.2 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.17 CDW60925.1 - 9e-08 31.7 3.6 0.033 14.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW60925.1 - 4e-07 30.1 0.4 1.2e-06 28.6 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CDW60925.1 - 0.0019 18.4 0.1 0.0058 16.9 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW60925.1 - 0.013 15.7 1.9 2 8.8 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CDW60925.1 - 0.018 15.3 0.1 2.8 8.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CDW60925.1 - 0.031 15.1 0.3 8.3 7.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat NYD-SP12_N PF15015.6 CDW60925.1 - 0.081 11.3 0.3 0.12 10.8 0.3 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal TPR_16 PF13432.6 CDW60925.1 - 0.21 12.3 1.1 0.53 11.0 0.0 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Fra10Ac1 PF09725.9 CDW60926.1 - 1.9e-42 144.3 4.1 1.9e-42 144.3 4.1 1.6 2 0 0 2 2 2 1 Folate-sensitive fragile site protein Fra10Ac1 Cofilin_ADF PF00241.20 CDW60927.1 - 1.2e-13 50.9 0.0 1.4e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Y2_Tnp PF04986.13 CDW60928.1 - 2.1e-39 135.5 1.7 2.8e-39 135.1 1.7 1.1 1 0 0 1 1 1 1 Putative transposase DBC1 PF14443.6 CDW60928.1 - 0.068 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 DBC1 Gp49 PF05973.14 CDW60929.1 - 1.1e-26 92.7 0.1 1.3e-26 92.6 0.1 1.0 1 0 0 1 1 1 1 Phage derived protein Gp49-like (DUF891) DEDD_Tnp_IS110 PF01548.17 CDW60930.1 - 1.8e-44 151.3 0.1 3.2e-44 150.5 0.1 1.4 1 0 0 1 1 1 1 Transposase Transposase_20 PF02371.16 CDW60930.1 - 8.6e-23 80.5 0.3 3.8e-22 78.4 0.6 2.0 2 0 0 2 2 2 1 Transposase IS116/IS110/IS902 family HHH_5 PF14520.6 CDW60930.1 - 0.00072 20.1 0.9 1.7 9.3 0.0 3.0 3 0 0 3 3 3 2 Helix-hairpin-helix domain zf-C3HC4_2 PF13923.6 CDW60931.1 - 1.5e-14 53.5 7.5 3.1e-14 52.5 7.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CDW60931.1 - 5.7e-10 38.9 8.4 1.3e-09 37.8 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CDW60931.1 - 3.1e-09 37.0 8.4 7e-09 35.9 8.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CDW60931.1 - 1.9e-07 30.9 7.1 4e-07 29.8 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 CDW60931.1 - 5.2e-07 29.4 3.6 1.1e-06 28.3 3.6 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 CDW60931.1 - 3.3e-06 27.0 8.3 7.4e-06 25.9 8.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CDW60931.1 - 5.4e-06 26.3 7.9 1.4e-05 24.9 7.9 1.8 1 0 0 1 1 1 1 zinc-RING finger domain RAWUL PF16207.5 CDW60931.1 - 3.7e-05 24.3 0.0 6.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_4 PF15227.6 CDW60931.1 - 8.5e-05 22.6 6.3 0.00024 21.2 6.3 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 CDW60931.1 - 0.00012 21.9 3.9 0.00032 20.5 3.9 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 CDW60931.1 - 0.00041 20.6 7.1 0.0021 18.3 7.1 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 CDW60931.1 - 0.0005 19.8 6.4 0.0012 18.5 6.4 1.7 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 CDW60931.1 - 0.003 17.4 7.6 0.012 15.5 7.6 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 CDW60931.1 - 0.009 16.1 6.8 0.02 15.0 6.8 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 CDW60931.1 - 0.031 14.1 8.8 2.4 8.1 8.6 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-MIZ PF02891.20 CDW60931.1 - 0.1 12.4 6.8 0.32 10.8 6.8 1.9 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger zf-UDP PF14569.6 CDW60931.1 - 0.87 9.8 8.0 0.58 10.3 5.2 2.1 2 1 0 2 2 2 0 Zinc-binding RING-finger zf-RING_11 PF17123.5 CDW60931.1 - 1.1 9.1 5.1 3 7.7 5.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger DZR PF12773.7 CDW60931.1 - 2.3 8.3 9.5 37 4.4 9.5 2.8 1 1 0 1 1 1 0 Double zinc ribbon Proton_antipo_M PF00361.20 CDW60935.1 - 2.1e-07 30.4 16.2 2.9e-07 30.0 16.2 1.3 1 0 0 1 1 1 1 Proton-conducting membrane transporter DUF908 PF06012.12 CDW60936.1 - 0.064 12.7 6.8 0.082 12.3 6.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) PI3K_1B_p101 PF10486.9 CDW60936.1 - 2.7 5.6 6.4 3.1 5.5 6.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CobT PF06213.12 CDW60936.1 - 2.8 7.2 14.8 3.1 7.1 14.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Menin PF05053.13 CDW60936.1 - 3.4 5.9 6.7 3.6 5.8 6.7 1.1 1 0 0 1 1 1 0 Menin RR_TM4-6 PF06459.12 CDW60936.1 - 4.2 7.1 11.1 4.3 7.1 11.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPL5 PF18168.1 CDW60936.1 - 4.3 6.5 9.7 4.8 6.4 9.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Zip PF02535.22 CDW60936.1 - 4.4 6.4 6.3 4.2 6.5 6.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 CDW60936.1 - 6.3 5.5 8.6 5.8 5.6 8.6 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.14 CDW60936.1 - 7.4 7.0 12.7 11 6.4 12.7 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 CDW60936.1 - 7.8 4.6 13.5 7.3 4.8 13.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 CDW60936.1 - 8.5 5.0 9.6 9.1 4.9 9.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 CDW60936.1 - 8.7 5.0 10.7 8.9 5.0 10.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RT_RNaseH_2 PF17919.1 CDW60937.1 - 8.9e-26 89.8 0.0 1.7e-25 89.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDW60937.1 - 4.4e-16 59.1 0.0 1.1e-15 57.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Retrotrans_gag PF03732.17 CDW60937.1 - 0.0046 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 Retrotransposon gag protein Asp_protease_2 PF13650.6 CDW60937.1 - 0.0094 16.6 0.0 0.026 15.2 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW60937.1 - 0.02 15.4 0.0 0.047 14.2 0.0 1.6 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease AID PF18767.1 CDW60937.1 - 0.15 12.1 0.0 0.45 10.6 0.0 1.8 1 0 0 1 1 1 0 Activation induced deaminase DUF5641 PF18701.1 CDW60938.1 - 9.8e-33 112.2 0.1 1.8e-32 111.4 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5641) BAG PF02179.16 CDW60938.1 - 0.14 12.6 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 BAG domain SF3b10 PF07189.11 CDW60939.1 - 7.6e-09 35.6 0.1 8.4e-09 35.4 0.1 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) AAA_33 PF13671.6 CDW60940.1 - 0.028 14.6 0.3 0.038 14.2 0.3 1.2 1 0 0 1 1 1 0 AAA domain TPD PF14811.6 CDW60940.1 - 0.2 11.5 0.0 0.27 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function TPD sequence-motif DNase_II PF03265.15 CDW60942.1 - 1.5e-43 149.3 0.4 1.9e-43 149.0 0.4 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II AA_permease PF00324.21 CDW60945.1 - 3.6e-147 490.8 41.6 4e-147 490.7 41.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CDW60945.1 - 9.7e-41 140.0 47.7 9.7e-41 140.0 47.7 1.7 1 1 1 2 2 2 1 Amino acid permease Synaptobrevin PF00957.21 CDW60945.1 - 6.2 6.7 8.2 67 3.4 3.6 3.4 3 0 0 3 3 3 0 Synaptobrevin LysR_substrate PF03466.20 CDW60946.1 - 7.8e-54 182.2 1.2 1.2e-53 181.6 1.2 1.2 1 0 0 1 1 1 1 LysR substrate binding domain HTH_1 PF00126.27 CDW60946.1 - 2.3e-15 56.3 1.0 2.3e-15 56.3 1.0 2.9 4 0 0 4 4 4 1 Bacterial regulatory helix-turn-helix protein, lysR family PBP_like PF12727.7 CDW60946.1 - 0.0017 17.5 0.0 0.0035 16.5 0.0 1.6 1 1 1 2 2 2 1 PBP superfamily domain PBP_like_2 PF12849.7 CDW60946.1 - 0.0088 15.7 0.0 0.064 12.9 0.0 2.3 2 1 0 2 2 2 1 PBP superfamily domain Phosphonate-bd PF12974.7 CDW60946.1 - 0.044 13.4 0.0 0.31 10.6 0.0 2.0 1 1 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Cons_hypoth698 PF03601.14 CDW60947.1 - 1.2e-117 392.2 25.3 1.4e-117 391.9 25.3 1.0 1 0 0 1 1 1 1 Conserved hypothetical protein 698 DUF2231 PF09990.9 CDW60947.1 - 0.081 13.4 0.7 0.081 13.4 0.7 3.5 2 1 1 3 3 3 0 Predicted membrane protein (DUF2231) LIDHydrolase PF10230.9 CDW60947.1 - 0.099 12.2 0.6 0.15 11.6 0.6 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase AP_endonuc_2 PF01261.24 CDW60948.1 - 5e-44 150.3 0.2 7.7e-44 149.7 0.2 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Flagellin_IN PF07196.13 CDW60948.1 - 0.013 15.6 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 Flagellin hook IN motif AAA_33 PF13671.6 CDW60950.1 - 5e-06 26.7 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 CDW60950.1 - 0.0069 15.6 0.1 0.014 14.6 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) CUE PF02845.16 CDW60950.1 - 0.01 15.5 3.2 1.2 8.9 0.0 3.6 3 0 0 3 3 3 0 CUE domain Histone PF00125.24 CDW60952.1 - 1.7e-50 170.7 3.7 1.9e-50 170.6 3.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW60952.1 - 6.7e-05 23.5 0.8 7.8e-05 23.3 0.8 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW60952.1 - 7e-05 22.9 0.8 0.00011 22.3 0.2 1.7 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW60952.1 - 0.0024 18.2 0.1 0.0038 17.6 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW60952.1 - 0.015 15.4 0.2 0.031 14.4 0.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW60952.1 - 0.05 13.9 0.1 0.096 13.0 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Pkinase PF00069.25 CDW60954.1 - 3.2e-20 72.6 0.0 4.1e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 CDW60954.1 - 0.00023 20.1 0.0 0.00032 19.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Rcd1 PF04078.13 CDW60955.1 - 4.1e-37 127.9 0.8 4.8e-37 127.7 0.8 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DUF1778 PF08681.11 CDW60955.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) DsbC PF11412.8 CDW60955.1 - 0.17 12.0 2.0 0.32 11.0 2.0 1.5 1 0 0 1 1 1 0 Disulphide bond corrector protein DsbC RRM_1 PF00076.22 CDW60956.1 - 2.1e-30 104.3 0.0 3.1e-15 55.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CDW60956.1 - 0.0047 17.0 0.1 2.9 8.1 0.0 2.9 2 2 0 2 2 2 2 RNA recognition motif RL PF17797.1 CDW60956.1 - 0.0059 16.5 0.1 2.6 8.1 0.0 2.6 2 1 0 2 2 2 2 RL domain PHM7_cyt PF14703.6 CDW60956.1 - 0.016 15.4 0.0 2.6 8.2 0.0 2.5 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM PF05172.13 CDW60956.1 - 0.068 13.1 0.0 3.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Galactosyl_T PF01762.21 CDW60957.1 - 1.9e-52 177.9 0.4 2.3e-52 177.7 0.4 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 CDW60957.1 - 0.013 14.9 0.2 0.02 14.3 0.2 1.3 1 0 0 1 1 1 0 Fringe-like WD40 PF00400.32 CDW60958.1 - 1.3e-13 51.2 3.1 4.7e-05 24.1 0.1 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CDW60958.1 - 9.1e-05 22.7 0.0 1.6 9.1 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain TUDOR PF00567.24 CDW60960.1 - 4.6e-05 23.4 0.0 9.3e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SAM_PNT PF02198.16 CDW60960.1 - 0.031 14.2 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Piwi PF02171.17 CDW60961.1 - 2.3e-85 286.5 0.0 4e-85 285.7 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoMid PF16487.5 CDW60961.1 - 5.3e-07 29.8 0.1 3.1e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 Mid domain of argonaute ArgoL2 PF16488.5 CDW60961.1 - 6.5e-07 29.6 0.0 1.6e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 CDW60961.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 PAZ domain FBPase_glpX PF03320.13 CDW60962.1 - 2.7e-87 292.5 0.3 3.6e-87 292.1 0.3 1.1 1 0 0 1 1 1 1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded MtlR PF05068.12 CDW60962.1 - 2.5e-33 115.4 0.0 4.4e-33 114.6 0.0 1.3 1 0 0 1 1 1 1 Mannitol repressor PRK PF00485.18 CDW60962.1 - 0.00062 19.6 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CDW60962.1 - 0.01 16.3 0.0 0.073 13.6 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CDW60962.1 - 0.015 15.7 0.0 0.027 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CDW60962.1 - 0.031 14.5 0.0 0.094 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CDW60962.1 - 0.11 12.7 0.1 1.2 9.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CDW60962.1 - 0.15 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain PGK PF00162.19 CDW60963.1 - 6.3e-139 463.1 0.9 8.9e-139 462.6 0.4 1.5 2 0 0 2 2 2 1 Phosphoglycerate kinase Gp_dh_C PF02800.20 CDW60963.1 - 3.7e-54 182.6 0.3 3.7e-54 182.6 0.3 1.7 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CDW60963.1 - 3.1e-35 120.6 0.0 9e-35 119.1 0.0 1.9 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 CDW60963.1 - 0.0024 18.5 0.1 0.013 16.1 0.0 2.3 2 1 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain TrkA_N PF02254.18 CDW60963.1 - 0.051 13.8 0.0 0.17 12.2 0.0 1.9 1 0 0 1 1 1 0 TrkA-N domain GFO_IDH_MocA PF01408.22 CDW60963.1 - 0.076 13.8 0.0 0.29 12.0 0.0 2.2 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold F_bP_aldolase PF01116.20 CDW60964.1 - 3.7e-43 148.0 0.1 4.2e-43 147.8 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II S-methyl_trans PF02574.16 CDW60964.1 - 0.043 13.6 0.0 0.059 13.2 0.0 1.2 1 0 0 1 1 1 0 Homocysteine S-methyltransferase MR_MLE_C PF13378.6 CDW60964.1 - 0.063 12.8 0.8 0.09 12.3 0.5 1.5 1 1 1 2 2 2 0 Enolase C-terminal domain-like IRK PF01007.20 CDW60965.1 - 0.014 15.2 0.0 0.018 14.9 0.0 1.3 1 1 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain MPC PF03650.13 CDW60966.1 - 1.8e-29 102.1 0.2 2.4e-29 101.7 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers PcfK PF14058.6 CDW60967.1 - 0.0012 19.2 0.0 0.0017 18.6 0.0 1.2 1 0 0 1 1 1 1 PcfK-like protein Gp-FAR-1 PF05823.12 CDW60967.1 - 0.044 14.1 0.0 0.13 12.6 0.0 1.7 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) rve PF00665.26 CDW60967.1 - 0.086 13.0 0.0 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 Integrase core domain rve_3 PF13683.6 CDW60967.1 - 0.098 12.4 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Integrase core domain Integrase_H2C2 PF17921.1 CDW60968.1 - 1.7e-13 50.5 0.9 5.4e-13 48.8 0.9 1.9 1 0 0 1 1 1 1 Integrase zinc binding domain DUF1758 PF05585.12 CDW60968.1 - 1.3e-11 44.5 0.0 2.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Putative peptidase (DUF1758) rve PF00665.26 CDW60968.1 - 1.3e-06 28.6 0.0 3.6e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDW60968.1 - 0.00033 20.8 0.2 0.00076 19.6 0.2 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Peptidase_A17 PF05380.13 CDW60968.1 - 0.00042 20.4 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase Asp_protease_2 PF13650.6 CDW60968.1 - 0.046 14.3 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease NDUF_B8 PF05821.11 CDW60969.1 - 2.7e-40 138.1 4.2 3.2e-40 137.9 4.2 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) DNase_II PF03265.15 CDW60970.1 - 1.3e-34 120.0 0.6 1.5e-34 119.7 0.6 1.1 1 0 0 1 1 1 1 Deoxyribonuclease II TAFII28 PF04719.14 CDW60972.1 - 8e-36 122.0 0.2 1.5e-35 121.1 0.2 1.5 1 0 0 1 1 1 1 hTAFII28-like protein conserved region Ribosomal_L11_N PF03946.14 CDW60972.1 - 9.4e-24 83.0 0.3 2e-23 82.0 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CDW60972.1 - 7.1e-12 45.7 0.1 1.8e-11 44.4 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain DUF4494 PF14902.6 CDW60973.1 - 7.5e-43 145.7 3.6 7.5e-43 145.7 3.6 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4494) SNF2_N PF00176.23 CDW60973.1 - 6.1e-18 64.7 0.0 2e-17 63.0 0.0 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain WDCP PF15390.6 CDW60973.1 - 0.015 13.7 0.3 0.015 13.7 0.3 3.0 1 1 2 3 3 3 0 WD repeat and coiled-coil-containing protein family KH_1 PF00013.29 CDW60974.1 - 0.018 14.8 0.0 0.064 13.1 0.0 1.8 2 0 0 2 2 2 0 KH domain KH_4 PF13083.6 CDW60974.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 KH domain PRD PF00874.20 CDW60975.1 - 0.091 13.1 0.0 5.1 7.5 0.0 2.8 2 1 0 2 2 2 0 PRD domain Dimer_Tnp_hAT PF05699.14 CDW60975.1 - 0.096 12.5 0.0 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 hAT family C-terminal dimerisation region DUF2746 PF10874.8 CDW60975.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) TFIID-31kDa PF02291.15 CDW60977.1 - 1.8e-24 86.1 0.0 2.8e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TFIID_20kDa PF03847.13 CDW60977.1 - 0.054 14.0 0.1 0.1 13.1 0.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A RVT_1 PF00078.27 CDW60978.1 - 4.7e-31 108.0 0.0 8e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 CDW60978.1 - 1.3e-29 102.6 0.0 7.7e-29 100.1 0.0 2.2 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CDW60978.1 - 1.8e-29 101.7 0.0 7.4e-29 99.7 0.0 2.1 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase rve PF00665.26 CDW60978.1 - 2e-19 70.0 0.0 5e-19 68.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain RVP PF00077.20 CDW60978.1 - 6.9e-07 29.5 0.0 8e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 Retroviral aspartyl protease zf-CCHC PF00098.23 CDW60978.1 - 0.00034 20.6 0.7 0.00068 19.6 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle Asp_protease_2 PF13650.6 CDW60978.1 - 0.0019 18.8 0.0 0.0054 17.3 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW60978.1 - 0.0099 16.4 0.0 0.03 14.9 0.0 1.9 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease rve_3 PF13683.6 CDW60978.1 - 0.014 15.1 0.0 0.1 12.4 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain EGF_2 PF07974.13 CDW60979.1 - 4.1e-10 39.8 57.9 0.0023 18.2 9.8 4.7 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 CDW60979.1 - 8.6e-08 32.3 50.4 6.2e-05 23.2 10.7 5.4 4 2 0 4 4 4 3 EGF-like domain hEGF PF12661.7 CDW60979.1 - 0.0018 18.8 38.3 0.016 15.8 0.9 5.8 4 1 0 4 4 4 3 Human growth factor-like EGF EGF_alliinase PF04863.13 CDW60979.1 - 0.037 14.4 6.6 0.037 14.4 6.6 4.6 3 1 1 4 4 4 0 Alliinase EGF-like domain Laminin_EGF PF00053.24 CDW60979.1 - 0.049 13.8 42.5 4.3 7.5 2.0 4.8 1 1 3 4 4 4 0 Laminin EGF domain ABC_tran PF00005.27 CDW60980.1 - 2.4e-08 34.6 0.2 2.5e-08 34.5 0.2 1.3 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW60980.1 - 0.00068 19.5 0.0 0.00068 19.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CDW60980.1 - 0.012 15.5 0.2 0.019 14.8 0.2 1.3 1 1 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 CDW60980.1 - 0.013 14.7 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_23 PF13476.6 CDW60980.1 - 0.019 15.5 0.1 0.029 14.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CDW60980.1 - 0.019 14.7 0.5 0.14 11.9 0.1 1.9 1 1 1 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 CDW60980.1 - 0.022 14.4 0.0 0.025 14.2 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.12 CDW60980.1 - 0.031 14.2 0.4 0.069 13.1 0.1 1.6 1 1 1 2 2 2 0 NACHT domain AAA_15 PF13175.6 CDW60980.1 - 0.035 13.8 0.0 0.035 13.8 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 CDW60980.1 - 0.035 14.2 0.4 0.049 13.7 0.3 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 CDW60980.1 - 0.041 14.1 0.0 0.047 14.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CDW60980.1 - 0.049 13.2 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 CDW60980.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 CDW60980.1 - 0.087 13.1 0.0 0.09 13.0 0.0 1.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF1935 PF09149.10 CDW60981.1 - 0.053 13.9 0.0 1.5 9.2 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1935) AAA_lid_9 PF17871.1 CDW60985.1 - 1e-35 121.8 4.8 1e-35 121.8 4.8 2.8 2 1 1 3 3 3 1 AAA lid domain AAA_2 PF07724.14 CDW60985.1 - 5.2e-31 108.0 0.0 2.3e-28 99.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Clp_N PF02861.20 CDW60985.1 - 2.8e-27 94.6 5.6 7e-13 48.5 0.1 3.1 3 0 0 3 3 2 2 Clp amino terminal domain, pathogenicity island component AAA PF00004.29 CDW60985.1 - 2.2e-24 86.4 0.0 1e-13 51.9 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CDW60985.1 - 1.1e-12 48.1 0.2 3.8e-06 27.0 0.0 3.8 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CDW60985.1 - 8.2e-12 45.8 5.3 3.4e-05 24.3 0.1 4.7 5 2 1 6 6 5 2 AAA ATPase domain AAA_22 PF13401.6 CDW60985.1 - 9.1e-07 29.2 4.6 0.064 13.5 0.1 5.0 3 2 0 3 3 3 2 AAA domain TniB PF05621.11 CDW60985.1 - 9.9e-07 28.3 0.1 0.055 12.9 0.0 3.9 2 2 2 4 4 4 2 Bacterial TniB protein IstB_IS21 PF01695.17 CDW60985.1 - 1.1e-06 28.5 0.1 0.029 14.1 0.0 2.9 3 0 0 3 3 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 CDW60985.1 - 1.1e-06 29.2 2.5 0.09 13.3 0.0 4.0 4 0 0 4 4 3 2 AAA domain Sigma54_activat PF00158.26 CDW60985.1 - 6.1e-06 26.0 0.2 0.015 15.0 0.0 3.5 2 2 1 3 3 3 1 Sigma-54 interaction domain RuvB_N PF05496.12 CDW60985.1 - 1.7e-05 24.6 0.6 0.55 10.0 0.0 3.9 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 CDW60985.1 - 4.7e-05 23.0 0.0 0.15 11.5 0.0 2.7 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_28 PF13521.6 CDW60985.1 - 7e-05 23.1 0.5 0.36 11.1 0.2 3.8 2 1 1 3 3 3 2 AAA domain ATPase_2 PF01637.18 CDW60985.1 - 7.2e-05 22.8 2.9 1.7 8.5 0.2 4.4 3 2 1 4 4 4 1 ATPase domain predominantly from Archaea Roc PF08477.13 CDW60985.1 - 8e-05 22.8 0.0 0.31 11.2 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CDW60985.1 - 0.00029 20.6 0.0 0.24 11.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 CDW60985.1 - 0.00043 19.5 1.0 0.36 10.0 0.0 3.2 3 1 0 3 3 3 2 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 CDW60985.1 - 0.00044 20.2 0.0 1.2 9.0 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase RNA_helicase PF00910.22 CDW60985.1 - 0.00047 20.5 0.0 1.1 9.7 0.0 2.5 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 CDW60985.1 - 0.00072 19.6 0.0 1.3 9.0 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 CDW60985.1 - 0.00096 19.7 2.0 0.9 10.0 0.0 3.6 3 1 0 3 3 3 1 ABC transporter Bac_DnaA PF00308.18 CDW60985.1 - 0.0012 18.8 0.2 1.8 8.4 0.0 3.4 3 0 0 3 3 3 1 Bacterial dnaA protein AAA_14 PF13173.6 CDW60985.1 - 0.0012 18.9 0.0 1.9 8.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 CDW60985.1 - 0.0019 18.2 0.0 0.15 12.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain ResIII PF04851.15 CDW60985.1 - 0.0029 17.6 0.2 4.8 7.1 0.0 3.7 3 1 1 4 4 3 0 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 CDW60985.1 - 0.0034 16.8 0.0 1.4 8.3 0.0 2.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 CDW60985.1 - 0.005 16.2 0.0 0.93 8.7 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.6 CDW60985.1 - 0.009 15.7 0.0 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_25 PF13481.6 CDW60985.1 - 0.015 14.9 0.0 1 8.9 0.0 3.0 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 CDW60985.1 - 0.018 14.9 1.4 0.54 10.0 0.0 3.1 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 CDW60985.1 - 0.022 15.1 0.0 0.73 10.2 0.2 2.8 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CDW60985.1 - 0.024 14.8 0.0 14 5.8 0.0 3.0 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CDW60985.1 - 0.027 14.2 0.0 0.72 9.6 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 CDW60985.1 - 0.035 14.0 0.0 7 6.5 0.0 2.8 2 0 0 2 2 2 0 NTPase SRP54 PF00448.22 CDW60985.1 - 0.048 13.3 0.0 1.7 8.2 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 CDW60985.1 - 0.11 12.6 0.1 28 4.8 0.0 3.1 3 0 0 3 3 2 0 50S ribosome-binding GTPase Torsin PF06309.11 CDW60985.1 - 0.13 12.4 0.0 0.4 10.8 0.0 1.8 2 0 0 2 2 1 0 Torsin CLP1_P PF16575.5 CDW60985.1 - 0.17 11.6 0.0 0.97 9.2 0.0 2.3 2 0 0 2 2 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_23 PF13476.6 CDW60985.1 - 0.97 9.9 22.5 3.3 8.2 0.0 4.1 2 1 2 4 4 2 0 AAA domain Fib_alpha PF08702.10 CDW60985.1 - 3.7 7.7 10.5 10 6.3 0.1 3.0 3 1 0 3 3 2 0 Fibrinogen alpha/beta chain family LMBR1 PF04791.16 CDW60985.1 - 4.4 6.1 5.0 45 2.8 0.0 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein Cu-oxidase_4 PF02578.15 CDW60986.1 - 2e-72 243.5 0.1 1.3e-71 240.9 0.1 2.0 1 1 0 1 1 1 1 Multi-copper polyphenol oxidoreductase laccase PseudoU_synth_2 PF00849.22 CDW60986.1 - 3.1e-31 108.6 0.1 4.6e-31 108.1 0.1 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 CDW60986.1 - 1e-08 34.7 0.0 1.9e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CDW60986.1 - 0.011 15.5 0.2 0.025 14.4 0.2 1.5 1 0 0 1 1 1 0 S4 domain TruB_N PF01509.18 CDW60986.1 - 0.072 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) YfiO PF13525.6 CDW60987.1 - 9.3e-86 286.7 5.1 1.1e-85 286.5 5.1 1.1 1 0 0 1 1 1 1 Outer membrane lipoprotein TPR_18 PF13512.6 CDW60987.1 - 2.3e-69 232.1 8.0 2.6e-68 228.7 2.3 2.0 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW60987.1 - 0.00058 20.0 2.4 1.7 9.0 0.0 3.3 3 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 CDW60987.1 - 0.00064 20.3 5.4 0.028 15.1 0.2 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW60987.1 - 0.0011 19.5 11.1 0.18 12.5 0.1 4.5 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 CDW60987.1 - 0.0038 17.9 3.7 9.8 7.3 0.0 4.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 CDW60987.1 - 0.014 15.5 1.4 6.5 7.0 0.0 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 CDW60987.1 - 0.061 13.0 1.9 0.089 12.5 0.1 2.0 1 1 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_19 PF14559.6 CDW60987.1 - 0.32 11.6 6.3 0.65 10.5 0.6 3.3 3 2 1 4 4 4 0 Tetratricopeptide repeat Trehalase PF01204.18 CDW60989.1 - 5.7e-47 160.7 0.0 6.5e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 CDW60989.1 - 0.0033 16.4 0.1 0.004 16.1 0.1 1.1 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase AATF-Che1 PF13339.6 CDW60991.1 - 1.6e-24 87.2 1.3 1.6e-24 87.2 1.3 2.8 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 CDW60991.1 - 5.1e-23 81.4 1.5 1e-22 80.4 0.1 2.3 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal DUF3263 PF11662.8 CDW60991.1 - 0.003 17.4 0.9 1.5 8.7 0.1 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF3263) KIX PF02172.16 CDW60991.1 - 0.028 14.7 0.1 0.12 12.6 0.1 2.1 1 0 0 1 1 1 0 KIX domain TPR_19 PF14559.6 CDW60992.1 - 3.6e-16 59.4 9.0 0.00077 19.9 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 CDW60992.1 - 2.6e-11 42.7 18.1 0.0036 17.3 1.0 9.0 9 0 0 9 9 9 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CDW60992.1 - 1.8e-06 27.9 4.3 5.3e-05 23.2 2.0 3.9 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 CDW60992.1 - 1.7e-05 24.4 31.1 0.0021 17.8 1.3 8.4 10 0 0 10 10 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CDW60992.1 - 2.3e-05 24.5 23.5 0.0033 17.6 0.7 6.4 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 CDW60992.1 - 4.3e-05 23.7 11.4 0.0045 17.3 0.1 6.4 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 CDW60992.1 - 6.4e-05 23.3 7.9 0.0083 16.7 0.6 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW60992.1 - 7e-05 22.7 7.1 0.21 11.9 1.2 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 CDW60992.1 - 0.00074 20.1 0.0 0.031 14.9 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 CDW60992.1 - 0.0013 18.8 15.6 0.14 12.2 0.2 4.7 3 2 1 4 4 4 2 Putative TPR-like repeat TPR_14 PF13428.6 CDW60992.1 - 0.0043 17.8 3.9 4.6 8.3 0.1 4.9 6 0 0 6 6 3 1 Tetratricopeptide repeat TetR_C_23 PF17931.1 CDW60992.1 - 0.063 13.4 0.3 0.2 11.8 0.2 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TPR_10 PF13374.6 CDW60992.1 - 0.26 11.2 3.0 2.4 8.1 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 CDW60992.1 - 0.54 10.4 13.7 10 6.4 0.2 6.4 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_3 PF07720.12 CDW60992.1 - 2.6 8.1 14.9 4.4 7.4 2.2 5.5 7 0 0 7 7 7 0 Tetratricopeptide repeat DDE_Tnp_1_6 PF13751.6 CDW60993.1 - 2.3e-29 102.2 1.4 3.6e-29 101.5 1.4 1.3 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1 PF01609.21 CDW60993.1 - 2.9e-19 69.6 0.3 4.3e-19 69.0 0.3 1.3 1 0 0 1 1 1 1 Transposase DDE domain DDE_5 PF13546.6 CDW60993.1 - 0.00067 19.1 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_Tnp_1_3 PF13612.6 CDW60993.1 - 0.0014 18.6 0.1 0.0063 16.5 0.0 2.0 2 0 0 2 2 2 1 Transposase DDE domain DDE_Tnp_4 PF13359.6 CDW60993.1 - 0.021 14.5 0.1 0.067 12.9 0.0 1.8 2 0 0 2 2 2 0 DDE superfamily endonuclease DDE_Tnp_1_2 PF13586.6 CDW60993.1 - 0.12 12.8 0.6 6.3 7.2 0.2 3.0 3 0 0 3 3 3 0 Transposase DDE domain Seryl_tRNA_N PF02403.22 CDW60995.1 - 0.00074 19.7 20.8 0.049 13.9 4.8 2.7 2 1 1 3 3 2 2 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 CDW60995.1 - 0.00099 19.4 8.9 0.00099 19.4 8.9 2.5 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) GAS PF13851.6 CDW60995.1 - 0.0058 16.0 21.8 0.02 14.2 21.7 2.0 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 CDW60995.1 - 0.014 15.4 10.1 0.1 12.6 1.9 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Leu_zip PF15294.6 CDW60995.1 - 0.015 14.9 17.8 0.2 11.2 7.8 2.2 2 0 0 2 2 2 0 Leucine zipper DotA PF11388.8 CDW60995.1 - 0.022 15.0 0.3 9.3 6.5 0.0 3.0 2 1 1 3 3 3 0 Phagosome trafficking protein DotA LMBR1 PF04791.16 CDW60995.1 - 0.03 13.2 9.6 0.036 13.0 9.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Occludin_ELL PF07303.13 CDW60995.1 - 0.036 14.8 13.4 0.14 12.9 4.1 2.7 1 1 1 2 2 2 0 Occludin homology domain DUF4407 PF14362.6 CDW60995.1 - 0.071 12.5 9.7 0.25 10.7 9.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Lip_prot_lig_C PF10437.9 CDW60995.1 - 0.081 12.9 2.1 0.14 12.1 0.1 2.5 3 0 0 3 3 2 0 Bacterial lipoate protein ligase C-terminus DUF948 PF06103.11 CDW60995.1 - 0.21 11.9 5.3 1.5 9.2 0.7 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) WDCP PF15390.6 CDW60995.1 - 0.28 9.5 10.9 0.34 9.3 10.9 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family HTH_Tnp_1_2 PF13022.6 CDW60995.1 - 0.33 11.1 7.8 0.51 10.5 0.7 3.0 2 2 1 3 3 3 0 Helix-turn-helix of insertion element transposase Sec34 PF04136.15 CDW60995.1 - 0.36 10.7 16.6 0.36 10.7 0.6 3.2 1 1 2 3 3 3 0 Sec34-like family PCRF PF03462.18 CDW60995.1 - 0.47 10.3 17.3 2 8.2 2.4 2.3 1 1 1 2 2 2 0 PCRF domain BRE1 PF08647.11 CDW60995.1 - 0.52 10.4 19.2 2.4 8.3 10.4 3.0 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase T3SSipB PF16535.5 CDW60995.1 - 0.58 10.6 9.1 0.8 10.2 2.5 2.8 1 1 2 3 3 3 0 Type III cell invasion protein SipB Fez1 PF06818.15 CDW60995.1 - 0.71 10.3 17.5 1.3 9.4 16.6 1.8 1 1 1 2 2 2 0 Fez1 ABC_tran_CTD PF16326.5 CDW60995.1 - 0.8 10.0 23.6 0.31 11.3 3.7 3.7 3 1 2 5 5 4 0 ABC transporter C-terminal domain Spc7 PF08317.11 CDW60995.1 - 0.86 8.4 22.0 1.5 7.7 19.7 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Prefoldin_2 PF01920.20 CDW60995.1 - 0.93 9.5 23.8 0.34 10.9 1.8 4.0 3 1 1 4 4 3 0 Prefoldin subunit Synaptobrevin PF00957.21 CDW60995.1 - 1.1 9.1 8.6 8.7 6.2 1.8 2.7 2 0 0 2 2 2 0 Synaptobrevin APG6_N PF17675.1 CDW60995.1 - 1.2 9.7 24.7 1 9.9 21.5 2.4 1 1 2 3 3 3 0 Apg6 coiled-coil region Glyco_H_20C_C PF18088.1 CDW60995.1 - 1.3 8.8 10.7 0.15 11.9 2.9 2.9 2 1 2 4 4 3 0 Glycoside Hydrolase 20C C-terminal domain DASH_Dad3 PF08656.10 CDW60995.1 - 1.3 9.2 18.0 0.71 10.0 0.6 4.0 1 1 1 2 2 2 0 DASH complex subunit Dad3 FemAB PF02388.16 CDW60995.1 - 1.5 7.7 12.4 0.45 9.3 4.3 2.2 2 0 0 2 2 2 0 FemAB family FapA PF03961.13 CDW60995.1 - 1.5 7.4 20.2 1.3 7.5 9.7 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A Syntaxin_2 PF14523.6 CDW60995.1 - 1.7 9.1 19.5 0.84 10.0 5.7 3.6 2 1 2 4 4 4 0 Syntaxin-like protein DUF745 PF05335.13 CDW60995.1 - 1.8 8.3 9.4 0.71 9.6 5.1 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF745) HemX PF04375.14 CDW60995.1 - 2 7.6 16.6 0.89 8.8 9.0 2.2 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Fmp27_WPPW PF10359.9 CDW60995.1 - 2.2 7.0 16.5 5 5.8 6.6 2.2 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Vps51 PF08700.11 CDW60995.1 - 2.3 8.4 13.0 7.8 6.7 0.6 4.1 3 1 1 4 4 3 0 Vps51/Vps67 Laminin_II PF06009.12 CDW60995.1 - 2.5 8.1 15.9 0.4 10.7 7.4 2.7 1 1 2 3 3 3 0 Laminin Domain II BLOC1_2 PF10046.9 CDW60995.1 - 2.8 8.3 19.5 2.7 8.3 5.5 3.9 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 V_ATPase_I PF01496.19 CDW60995.1 - 3 5.6 16.5 13 3.5 16.6 1.9 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family 3HCDH_N PF02737.18 CDW60995.1 - 3.9 7.3 7.3 0.82 9.5 1.2 2.6 3 1 1 4 4 4 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TMF_TATA_bd PF12325.8 CDW60995.1 - 5.8 7.2 21.0 0.51 10.6 8.8 2.9 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DHR10 PF18595.1 CDW60995.1 - 5.8 7.0 22.5 2.6 8.1 8.7 3.9 2 1 2 4 4 4 0 Designed helical repeat protein 10 domain LOH1CR12 PF10158.9 CDW60995.1 - 7 6.7 9.1 0.41 10.7 2.0 2.3 2 1 0 3 3 2 0 Tumour suppressor protein zf-C4H2 PF10146.9 CDW60995.1 - 9.3 6.5 14.5 0.15 12.3 3.3 2.4 1 1 1 2 2 2 0 Zinc finger-containing protein BTB PF00651.31 CDW60999.1 - 1.8e-06 28.1 0.0 6.4e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 BTB/POZ domain PCNA_N PF00705.18 CDW60999.1 - 0.0079 15.9 0.2 0.021 14.6 0.2 1.7 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain AcylCoA_dehyd_C PF12186.8 CDW60999.1 - 0.022 14.9 0.1 7.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase C terminal PTPS PF01242.19 CDW61001.1 - 2e-11 43.9 1.3 3.3e-11 43.2 0.1 1.7 1 1 1 2 2 2 1 6-pyruvoyl tetrahydropterin synthase Vps8 PF12816.7 CDW61001.1 - 0.011 15.2 0.1 0.013 15.1 0.1 1.1 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Pkinase PF00069.25 CDW61009.1 - 4.1e-28 98.5 0.1 4.9e-28 98.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW61009.1 - 1.7e-17 63.6 0.0 2.2e-17 63.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CDW61009.1 - 8.9e-05 21.4 0.0 0.00013 20.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 CDW61009.1 - 0.00018 21.7 1.1 0.0017 18.5 0.1 2.4 2 1 1 3 3 3 1 ABC1 family APH PF01636.23 CDW61009.1 - 0.0083 16.1 0.0 0.032 14.2 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CDW61009.1 - 0.01 15.2 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FANCI_HD2 PF14680.6 CDW61010.1 - 3.3e-25 88.7 0.1 7.2e-25 87.6 0.1 1.5 1 0 0 1 1 1 1 FANCI helical domain 2 FANCI_S2 PF14676.6 CDW61010.1 - 0.026 14.8 0.1 2.9 8.2 0.0 2.7 2 0 0 2 2 2 0 FANCI solenoid 2 gag_pre-integrs PF13976.6 CDW61011.1 - 6.8e-06 25.8 0.0 1.9e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 GAG-pre-integrase domain Dimer_Tnp_hAT PF05699.14 CDW61012.1 - 0.016 15.0 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 hAT family C-terminal dimerisation region RT_RNaseH_2 PF17919.1 CDW61015.1 - 1.2e-28 99.1 0.0 3.9e-28 97.4 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDW61015.1 - 5.6e-28 97.3 0.0 1.5e-27 95.9 0.0 1.7 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase MobA_MobL PF03389.15 CDW61017.1 - 1.4e-70 237.5 4.6 1.4e-70 237.5 4.6 3.1 2 2 1 3 3 3 1 MobA/MobL family FUSC PF04632.12 CDW61017.1 - 0.034 12.7 7.3 0.059 11.9 7.3 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family FlxA PF14282.6 CDW61017.1 - 9.8 6.2 9.5 23 5.1 9.5 1.5 1 0 0 1 1 1 0 FlxA-like protein Rep_3 PF01051.21 CDW61018.1 - 3.2e-56 190.6 2.5 3.7e-56 190.4 2.5 1.0 1 0 0 1 1 1 1 Initiator Replication protein RepC PF06504.11 CDW61018.1 - 0.0027 17.0 0.0 0.0029 16.8 0.0 1.1 1 0 0 1 1 1 1 Replication protein C (RepC) DIX PF00778.17 CDW61018.1 - 0.051 13.4 0.6 0.79 9.6 0.1 2.7 1 1 2 3 3 3 0 DIX domain MobA_MobL PF03389.15 CDW61020.1 - 1.8e-35 122.7 0.3 2e-35 122.5 0.3 1.0 1 0 0 1 1 1 1 MobA/MobL family PCI PF01399.27 CDW61023.1 - 0.035 14.6 0.0 0.063 13.8 0.0 1.4 1 1 0 1 1 1 0 PCI domain PCI PF01399.27 CDW61024.1 - 8.7e-17 61.5 0.0 1.4e-16 60.8 0.0 1.4 1 0 0 1 1 1 1 PCI domain zf-C2H2 PF00096.26 CDW61026.1 - 3.9e-05 23.9 14.1 0.0015 18.8 0.1 4.1 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW61026.1 - 0.00025 21.6 12.3 0.07 14.0 0.1 3.7 3 1 1 4 4 4 2 C2H2-type zinc finger HypA PF01155.19 CDW61026.1 - 0.0086 16.1 1.7 1.4 9.0 0.1 2.7 1 1 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_ZHX PF18387.1 CDW61026.1 - 0.027 14.1 1.8 0.53 10.0 0.1 2.4 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_4 PF13717.6 CDW61026.1 - 0.14 12.1 4.7 3.2 7.7 0.0 3.3 2 1 0 2 2 2 0 zinc-ribbon domain zf-C2H2_11 PF16622.5 CDW61026.1 - 0.15 11.9 0.5 0.15 11.9 0.5 2.3 4 0 0 4 4 3 0 zinc-finger C2H2-type CpXC PF14353.6 CDW61026.1 - 0.17 11.9 3.7 0.66 10.0 0.0 2.6 1 1 1 2 2 2 0 CpXC protein zf-C2H2_6 PF13912.6 CDW61026.1 - 0.54 10.3 0.1 0.54 10.3 0.1 3.4 4 1 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CDW61026.1 - 0.7 10.3 2.7 42 4.6 0.1 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) IBR PF01485.21 CDW61026.1 - 1 9.7 4.3 1.6 9.0 0.4 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DZR PF12773.7 CDW61026.1 - 1.1 9.3 5.8 60 3.8 5.8 2.5 1 1 0 1 1 1 0 Double zinc ribbon MRI PF15325.6 CDW61027.1 - 7.8 7.6 7.5 8.1 7.6 0.3 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection P22_CoatProtein PF11651.8 CDW61030.1 - 7e-16 57.8 3.6 3.5e-12 45.7 2.0 2.6 2 1 1 3 3 3 2 P22 coat protein - gene protein 5 Tmemb_cc2 PF10267.9 CDW61030.1 - 0.013 14.7 1.4 0.018 14.2 1.4 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Dzip-like_N PF13815.6 CDW61030.1 - 0.092 12.7 0.7 0.3 11.1 0.0 2.1 2 0 0 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal Zn_Tnp_IS1595 PF12760.7 CDW61034.1 - 0.0016 18.4 5.2 0.0019 18.1 1.4 2.6 2 0 0 2 2 2 1 Transposase zinc-ribbon domain zf-C2H2 PF00096.26 CDW61034.1 - 0.002 18.5 0.2 0.002 18.5 0.2 4.2 4 1 0 4 4 4 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CDW61034.1 - 0.014 16.2 13.7 0.37 11.8 0.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zinc_ribbon_10 PF10058.9 CDW61034.1 - 0.017 14.9 1.2 0.78 9.5 0.9 2.6 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_3rep PF18868.1 CDW61034.1 - 0.034 14.8 0.1 0.084 13.6 0.1 1.7 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf_C2H2_ZHX PF18387.1 CDW61034.1 - 0.048 13.3 3.8 0.18 11.5 0.2 2.4 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain HypA PF01155.19 CDW61034.1 - 0.058 13.4 4.8 3.3 7.7 0.0 2.9 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Spt46 PF17734.1 CDW61034.1 - 0.073 12.9 1.2 0.15 11.8 0.4 1.9 2 0 0 2 2 2 0 Spermatogenesis-associated protein 46 Elf1 PF05129.13 CDW61034.1 - 0.25 11.4 5.1 27 4.9 5.1 2.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-C2H2_11 PF16622.5 CDW61034.1 - 0.27 11.0 4.5 0.24 11.2 0.4 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type zinc_ribbon_4 PF13717.6 CDW61034.1 - 0.49 10.4 5.9 9.5 6.2 2.8 3.4 3 1 0 3 3 3 0 zinc-ribbon domain CpXC PF14353.6 CDW61034.1 - 0.87 9.6 4.5 6.9 6.7 0.0 2.9 2 1 0 2 2 2 0 CpXC protein zf-H2C2_2 PF13465.6 CDW61034.1 - 1.1 9.8 11.0 6.1 7.5 0.5 3.9 4 0 0 4 4 4 0 Zinc-finger double domain Tom7 PF08038.12 CDW61035.1 - 2.4e-07 30.3 0.1 3.3e-07 29.9 0.1 1.2 1 0 0 1 1 1 1 TOM7 family Alg14 PF08660.11 CDW61036.1 - 2.8e-55 186.9 0.0 3.2e-55 186.7 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like NIF PF03031.18 CDW61038.1 - 0.00087 19.1 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Hist_deacetyl PF00850.19 CDW61039.1 - 2.8e-20 73.0 0.0 3.1e-20 72.9 0.0 1.0 1 0 0 1 1 1 1 Histone deacetylase domain Ribonuc_red_lgC PF02867.15 CDW61040.1 - 8.6e-144 479.9 0.0 3.1e-142 474.8 0.0 2.2 1 1 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_sm PF00268.21 CDW61040.1 - 8.8e-85 284.5 0.9 1.5e-84 283.8 0.9 1.4 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ribonuc_red_lgN PF00317.21 CDW61040.1 - 2e-18 66.1 0.1 6.6e-18 64.5 0.1 2.0 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CDW61040.1 - 1.1e-08 35.5 1.2 1.1e-07 32.4 0.3 2.8 3 0 0 3 3 3 1 ATP cone domain UPF0253 PF06786.12 CDW61040.1 - 0.065 13.5 0.1 4.4 7.7 0.0 3.5 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0253) RNR_N PF08343.10 CDW61040.1 - 0.19 11.8 1.0 0.84 9.7 0.0 2.6 3 0 0 3 3 3 0 Ribonucleotide reductase N-terminal TM1586_NiRdase PF14512.6 CDW61041.1 - 9.9e-32 110.2 0.0 2.5e-31 108.9 0.0 1.6 1 1 0 1 1 1 1 Putative TM nitroreductase Nitroreductase PF00881.24 CDW61041.1 - 3.1e-15 56.6 0.7 2e-11 44.2 0.0 3.2 2 1 1 3 3 3 3 Nitroreductase family DUF1759 PF03564.15 CDW61044.1 - 0.012 15.6 1.8 0.14 12.1 1.8 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1759) eIF3g PF12353.8 CDW61044.1 - 0.13 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G zf-C2H2 PF00096.26 CDW61047.1 - 0.026 15.0 0.2 0.026 15.0 0.2 4.6 3 1 1 4 4 4 0 Zinc finger, C2H2 type HypA PF01155.19 CDW61047.1 - 0.099 12.7 4.5 0.37 10.8 4.2 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Fer4_6 PF12837.7 CDW61047.1 - 0.15 12.2 4.3 0.21 11.7 0.4 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain zf-C2H2_4 PF13894.6 CDW61047.1 - 0.32 11.9 0.1 0.32 11.9 0.1 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger Fer4_2 PF12797.7 CDW61047.1 - 0.68 10.2 4.6 1 9.6 1.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_10 PF13237.6 CDW61047.1 - 0.75 10.0 9.4 0.13 12.4 5.1 2.0 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4 PF00037.27 CDW61047.1 - 1.7 8.6 6.9 0.39 10.6 1.7 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Integrase_H2C2 PF17921.1 CDW61048.1 - 1.8e-08 34.3 0.8 4e-08 33.2 0.8 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain DDE_Tnp_IS66 PF03050.14 CDW61049.1 - 1e-23 84.2 0.0 1.5e-23 83.7 0.0 1.2 1 0 0 1 1 1 1 Transposase IS66 family DDE_Tnp_IS66_C PF13817.6 CDW61049.1 - 3.1e-14 52.9 0.8 5e-14 52.2 0.8 1.4 1 0 0 1 1 1 1 IS66 C-terminal element DUF1778 PF08681.11 CDW61050.1 - 8e-24 83.4 1.6 8.8e-24 83.2 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1778) Op_neuropeptide PF08035.11 CDW61050.1 - 1.3 9.0 2.9 2.2 8.2 2.9 1.4 1 0 0 1 1 1 0 Opioids neuropeptide HTH_Tnp_1 PF01527.20 CDW61051.1 - 1.7e-07 31.4 0.0 2.2e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Transposase TSC22 PF01166.18 CDW61051.1 - 0.016 15.5 0.5 0.04 14.2 0.6 1.5 2 0 0 2 2 2 0 TSC-22/dip/bun family Metallophos PF00149.28 CDW61052.1 - 0.023 15.2 0.0 0.038 14.5 0.0 1.4 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase DUF4581 PF15167.6 CDW61052.1 - 0.077 13.2 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4581) Homeodomain PF00046.29 CDW61053.1 - 2.9e-18 65.4 5.8 4.1e-18 65.0 5.8 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CDW61053.1 - 8.1e-05 22.4 1.0 0.0001 22.2 0.1 1.6 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 CDW61053.1 - 0.0038 16.7 0.1 0.0068 15.8 0.1 1.4 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Suv3_N PF18114.1 CDW61053.1 - 0.023 14.8 0.1 0.033 14.3 0.1 1.3 1 0 0 1 1 1 0 Suv3 helical N-terminal domain Ion_trans_2 PF07885.16 CDW61056.1 - 3.7e-33 113.3 14.3 1.7e-18 66.3 0.4 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 CDW61056.1 - 0.00032 20.0 7.9 0.0031 16.8 0.1 2.2 2 0 0 2 2 2 2 Ion transport protein PAP_assoc PF03828.19 CDW61057.1 - 3.9e-08 33.4 1.7 3.9e-08 33.4 1.7 2.2 2 1 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CDW61057.1 - 0.00049 20.3 0.0 0.00093 19.4 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain eIF2A PF08662.11 CDW61058.1 - 1.3e-41 142.7 4.2 3.7e-38 131.4 0.6 3.5 2 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 CDW61058.1 - 1.8e-08 34.1 0.1 4.7e-08 32.7 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 CDW61058.1 - 0.1 13.5 7.7 0.81 10.7 0.4 4.6 6 0 0 6 6 6 0 WD domain, G-beta repeat WBS_methylT PF12589.8 CDW61058.1 - 0.24 12.2 2.2 0.49 11.2 2.2 1.5 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome Histone PF00125.24 CDW61060.1 - 6.8e-20 71.8 0.3 8.1e-20 71.5 0.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW61060.1 - 1e-06 28.9 1.3 2e-06 27.9 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YscO-like PF16789.5 CDW61060.1 - 0.003 17.6 0.2 0.0038 17.3 0.2 1.1 1 0 0 1 1 1 1 YscO-like protein TFIID_20kDa PF03847.13 CDW61060.1 - 0.0042 17.6 0.0 0.0064 17.0 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF1931 PF09123.11 CDW61060.1 - 0.035 14.2 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) Kunitz_BPTI PF00014.23 CDW61061.1 - 2e-65 216.8 38.3 5.9e-21 74.5 9.3 4.2 4 0 0 4 4 4 4 Kunitz/Bovine pancreatic trypsin inhibitor domain WW PF00397.26 CDW61061.1 - 0.023 14.8 1.6 7.4 6.8 1.0 2.6 2 0 0 2 2 2 0 WW domain Voldacs PF03517.13 CDW61061.1 - 0.6 10.2 4.4 0.88 9.7 4.4 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Retrotrans_gag PF03732.17 CDW61062.1 - 0.021 15.1 0.2 0.063 13.6 0.0 2.0 2 1 0 2 2 2 0 Retrotransposon gag protein DUF1759 PF03564.15 CDW61064.1 - 1.3e-30 106.3 0.0 2.2e-30 105.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 CDW61064.1 - 4.4e-11 42.8 0.0 8.7e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 CDW61064.1 - 0.018 15.7 0.0 0.044 14.4 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_4 PF14392.6 CDW61064.1 - 0.4 10.5 8.2 0.69 9.7 0.5 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 CDW61064.1 - 3.5 7.5 14.0 2.9 7.8 3.0 2.9 3 0 0 3 3 3 0 Zinc knuckle Proton_antipo_M PF00361.20 CDW61065.1 - 2.9e-05 23.4 2.4 5.4e-05 22.5 2.4 1.6 1 1 0 1 1 1 1 Proton-conducting membrane transporter Ribosomal_S17 PF00366.20 CDW61066.1 - 1.6e-34 117.8 1.2 1.9e-34 117.6 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 Ribosomal_L14 PF00238.19 CDW61067.1 - 3.8e-43 146.5 2.6 5.4e-43 146.0 1.3 1.8 1 1 1 2 2 2 1 Ribosomal protein L14p/L23e Ribosomal_L5_C PF00673.21 CDW61067.1 - 1.6e-40 137.2 0.0 3.1e-40 136.3 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CDW61067.1 - 4e-28 97.5 0.3 4e-28 97.5 0.3 2.1 2 0 0 2 2 2 1 Ribosomal protein L5 ribosomal_L24 PF17136.4 CDW61067.1 - 5e-14 52.4 0.3 1.3e-13 51.1 0.3 1.8 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 CDW61067.1 - 0.00059 19.7 3.2 0.00059 19.7 3.2 2.3 2 0 0 2 2 2 1 KOW motif Ribosomal_S14 PF00253.21 CDW61068.1 - 7.5e-27 92.9 1.6 1e-26 92.4 1.6 1.2 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Ribosomal_S8 PF00410.19 CDW61069.1 - 3.6e-42 143.3 0.0 1e-41 141.9 0.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L6 PF00347.23 CDW61069.1 - 3.9e-39 133.2 0.2 5.2e-18 65.5 0.0 2.8 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S5_C PF03719.15 CDW61069.1 - 4.6e-30 102.9 0.4 1e-29 101.8 0.4 1.7 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CDW61069.1 - 7.6e-29 99.5 3.4 2e-28 98.2 3.4 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_L27A PF00828.19 CDW61070.1 - 1.4e-15 58.1 7.5 2e-15 57.6 7.5 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A SH3_13 PF18335.1 CDW61071.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain Neur_chan_LBD PF02931.23 CDW61073.1 - 2.4e-05 23.9 0.0 2.9e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Arm PF00514.23 CDW61074.1 - 2.5e-05 24.1 0.0 2.5e-05 24.1 0.0 4.7 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 CDW61074.1 - 0.0003 20.3 0.0 0.0059 16.1 0.0 2.2 2 1 0 2 2 2 1 Armadillo-like V-ATPase_H_C PF11698.8 CDW61074.1 - 0.0087 16.2 0.1 0.063 13.4 0.0 2.3 2 1 1 3 3 3 1 V-ATPase subunit H DUF3361 PF11841.8 CDW61074.1 - 0.047 13.6 0.3 0.2 11.6 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) Cnd1 PF12717.7 CDW61074.1 - 0.091 12.8 1.6 0.62 10.1 0.0 2.9 2 2 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 LSM PF01423.22 CDW61076.1 - 5.8e-21 74.0 0.0 7.1e-21 73.7 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CDW61076.1 - 0.0046 17.1 0.0 0.0052 16.9 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain CspB_prodomain PF18425.1 CDW61076.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Csp protease B prodomain INCENP_ARK-bind PF03941.15 CDW61079.1 - 0.0016 18.3 0.9 0.0027 17.6 0.9 1.4 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region TMEM214 PF10151.9 CDW61079.1 - 0.16 10.4 0.0 0.18 10.2 0.0 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator RVT_1 PF00078.27 CDW61080.1 - 2.6e-05 23.8 0.0 4.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) gag-asp_proteas PF13975.6 CDW61080.1 - 0.035 14.7 0.0 0.07 13.7 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW61080.1 - 0.039 14.6 0.0 0.089 13.5 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 CDW61080.1 - 0.16 12.3 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Motile_Sperm PF00635.26 CDW61081.1 - 2.3e-13 49.9 0.0 3.6e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Retrotrans_gag PF03732.17 CDW61082.1 - 0.00062 20.0 0.1 0.0012 19.0 0.1 1.5 1 0 0 1 1 1 1 Retrotransposon gag protein zf-UBR PF02207.20 CDW61083.1 - 2.4e-19 69.2 1.4 4.7e-19 68.3 1.4 1.5 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 CDW61083.1 - 0.037 14.2 1.0 0.093 12.9 1.0 1.6 1 1 0 1 1 1 0 B-box zinc finger XendoU PF09412.10 CDW61083.1 - 0.13 11.5 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Endoribonuclease XendoU RVT_1 PF00078.27 CDW61085.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) FANCI_S1 PF14675.6 CDW61086.1 - 6e-12 45.6 0.8 1.9e-11 44.0 0.8 1.7 1 1 0 1 1 1 1 FANCI solenoid 1 Trehalase PF01204.18 CDW61087.1 - 2.2e-27 96.1 8.8 1.8e-16 60.1 1.3 2.0 1 1 1 2 2 2 2 Trehalase Cation_ATPase_C PF00689.21 CDW61088.1 - 3.4e-42 144.2 5.0 6.4e-42 143.3 5.0 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CDW61088.1 - 4.8e-20 71.4 0.1 9.3e-20 70.5 0.1 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CDW61088.1 - 3.4e-15 56.9 0.1 7.4e-14 52.5 0.2 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CDW61088.1 - 2.4e-07 30.8 0.7 2.3e-05 24.3 0.6 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase ATP_Ca_trans_C PF12424.8 CDW61088.1 - 1.9e-05 25.0 3.6 1.9e-05 25.0 3.6 2.3 2 0 0 2 2 2 1 Plasma membrane calcium transporter ATPase C terminal GatB_N PF02934.15 CDW61089.1 - 7.9e-69 232.1 0.1 3.3e-68 230.0 0.1 1.9 1 1 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 CDW61089.1 - 1.5e-14 54.1 0.0 3e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 GatB domain DUF1107 PF06526.12 CDW61089.1 - 0.009 15.9 0.0 0.031 14.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1107) BACK PF07707.15 CDW61090.1 - 6.4e-31 106.5 5.0 8.1e-31 106.2 0.5 2.7 3 0 0 3 3 3 1 BTB And C-terminal Kelch BTB PF00651.31 CDW61090.1 - 3.2e-22 78.9 5.2 4.1e-21 75.3 2.0 3.5 2 2 1 3 3 3 1 BTB/POZ domain HU-CCDC81_euk_1 PF14908.6 CDW61090.1 - 0.18 12.0 0.1 0.72 10.1 0.0 2.0 2 1 1 3 3 3 0 CCDC81 eukaryotic HU domain 1 ERG2_Sigma1R PF04622.12 CDW61091.1 - 2e-13 50.2 0.0 2.4e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Kunitz_BPTI PF00014.23 CDW61093.1 - 1.6e-57 191.6 33.4 3.5e-20 72.0 7.4 3.1 3 0 0 3 3 3 3 Kunitz/Bovine pancreatic trypsin inhibitor domain ATP1G1_PLM_MAT8 PF02038.16 CDW61093.1 - 3 7.3 4.6 8.9 5.8 0.3 2.7 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Inhibitor_I68 PF10468.9 CDW61093.1 - 4.5 7.7 14.2 4.4 7.8 2.3 2.7 3 0 0 3 3 3 0 Carboxypeptidase inhibitor I68 DUF1758 PF05585.12 CDW61094.1 - 3.8e-06 26.8 0.0 4.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase (DUF1758) PNISR PF15996.5 CDW61096.1 - 0.028 14.7 0.1 0.035 14.4 0.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Rod_C PF10493.9 CDW61097.1 - 0.0039 15.6 0.0 0.0049 15.3 0.0 1.0 1 0 0 1 1 1 1 Rough deal protein C-terminal region TruB_N PF01509.18 CDW61097.1 - 0.057 13.8 0.0 0.088 13.2 0.0 1.3 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Voldacs PF03517.13 CDW61097.1 - 0.063 13.4 0.8 0.093 12.9 0.8 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DUF1758 PF05585.12 CDW61098.1 - 1e-06 28.6 0.0 1.5e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase (DUF1758) RtcB PF01139.17 CDW61099.1 - 7e-47 160.5 0.3 1e-46 160.0 0.3 1.2 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Copine PF07002.16 CDW61099.1 - 0.029 13.8 0.0 0.061 12.8 0.0 1.5 1 1 0 1 1 1 0 Copine MatE PF01554.18 CDW61100.1 - 0.00061 19.5 4.9 0.14 11.8 2.5 2.0 1 1 1 2 2 2 2 MatE Kinocilin PF15033.6 CDW61100.1 - 0.019 14.6 1.3 0.03 14.0 1.3 1.3 1 0 0 1 1 1 0 Kinocilin protein DUF4371 PF14291.6 CDW61102.1 - 0.00013 21.7 0.0 0.00029 20.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) Cnd1 PF12717.7 CDW61103.1 - 1.1e-55 188.1 0.6 1.3e-55 187.8 0.6 1.1 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CDW61103.1 - 4.6e-41 141.0 0.6 5.1e-41 140.8 0.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 CDW61103.1 - 5.1e-11 42.8 0.0 0.00032 21.0 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 CDW61103.1 - 4.5e-09 35.8 4.8 0.0005 20.1 0.0 3.6 4 0 0 4 4 4 2 HEAT repeat Arm PF00514.23 CDW61103.1 - 4.3e-06 26.6 1.1 0.04 14.0 0.0 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CDW61103.1 - 0.00088 19.7 0.4 2.2 8.9 0.1 2.8 2 1 0 2 2 2 2 HEAT-like repeat CLASP_N PF12348.8 CDW61103.1 - 0.0013 18.3 0.2 0.074 12.6 0.0 2.2 1 1 1 2 2 2 1 CLASP N terminal Arm_2 PF04826.13 CDW61103.1 - 0.0071 15.8 0.0 0.0098 15.4 0.0 1.3 1 0 0 1 1 1 1 Armadillo-like UNC45-central PF11701.8 CDW61103.1 - 0.01 15.8 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central RTP1_C1 PF10363.9 CDW61103.1 - 0.023 14.9 0.0 0.32 11.2 0.0 2.1 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 CDW61103.1 - 0.026 14.8 0.0 4.9 7.6 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Cation_efflux PF01545.21 CDW61104.1 - 2.8e-13 50.1 9.1 3.6e-12 46.5 3.6 2.3 1 1 1 2 2 2 2 Cation efflux family ZT_dimer PF16916.5 CDW61104.1 - 2.2e-12 46.9 1.5 4e-12 46.1 1.5 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF3285 PF11688.8 CDW61104.1 - 0.09 12.7 0.3 0.25 11.3 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) DUF2004 PF09406.10 CDW61106.1 - 0.047 14.0 0.0 0.064 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2004) Sulfotransfer_1 PF00685.27 CDW61107.1 - 1.5e-13 50.9 0.1 1.9e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Ribosomal_S17_N PF16205.5 CDW61108.1 - 1.1e-25 89.7 1.4 1.4e-25 89.4 0.2 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CDW61108.1 - 2.6e-25 88.3 3.5 3.7e-25 87.8 3.5 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 PRF PF06875.11 CDW61108.1 - 0.033 13.6 0.1 0.048 13.1 0.1 1.1 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF Peptidase_A17 PF05380.13 CDW61109.1 - 1.7e-49 167.9 0.0 3.6e-49 166.9 0.0 1.6 1 0 0 1 1 1 1 Pao retrotransposon peptidase Integrase_H2C2 PF17921.1 CDW61109.1 - 7.7e-10 38.7 0.1 7.7e-10 38.7 0.1 2.8 3 0 0 3 3 3 1 Integrase zinc binding domain RVT_1 PF00078.27 CDW61109.1 - 3.4e-08 33.3 0.0 8.9e-08 31.9 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1758 PF05585.12 CDW61109.1 - 9.3e-06 25.5 0.0 9.3e-05 22.3 0.0 2.1 1 1 0 1 1 1 1 Putative peptidase (DUF1758) rve PF00665.26 CDW61109.1 - 4.7e-05 23.6 0.0 0.00016 21.9 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Anti-TRAP PF15777.5 CDW61109.1 - 0.0083 16.1 3.0 0.0083 16.1 3.0 2.1 2 0 0 2 2 2 1 Tryptophan RNA-binding attenuator protein inhibitory protein DUF1759 PF03564.15 CDW61109.1 - 0.01 15.7 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) zf-CCHC PF00098.23 CDW61109.1 - 0.034 14.2 0.5 0.12 12.4 0.5 2.1 1 0 0 1 1 1 0 Zinc knuckle Asp_protease_2 PF13650.6 CDW61109.1 - 0.043 14.5 0.0 0.13 12.9 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease Peptidase_C1 PF00112.23 CDW61110.1 - 1.2e-27 97.4 4.1 1.4e-27 97.2 4.1 1.0 1 0 0 1 1 1 1 Papain family cysteine protease RVT_1 PF00078.27 CDW61112.1 - 3.4e-06 26.7 0.1 1.3e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CDW61112.1 - 0.00075 19.5 1.0 0.00075 19.5 1.0 1.9 2 0 0 2 2 2 1 Zinc knuckle gag-asp_proteas PF13975.6 CDW61112.1 - 0.0016 19.0 0.0 0.0066 17.0 0.0 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW61112.1 - 0.023 15.3 0.0 0.067 13.8 0.0 1.8 1 0 0 1 1 1 0 Aspartyl protease YhfH PF14149.6 CDW61112.1 - 0.08 12.9 2.1 4.5 7.3 0.0 2.6 2 0 0 2 2 2 0 YhfH-like protein zf-CCHC_4 PF14392.6 CDW61112.1 - 1.3 8.8 3.6 0.54 10.0 0.5 2.0 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 CDW61112.1 - 2.9 7.8 7.8 0.87 9.5 1.3 2.5 1 1 1 2 2 2 0 Zinc knuckle Ribosomal_L36e PF01158.18 CDW61113.1 - 1.4e-41 140.7 7.2 1.5e-41 140.5 7.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e SapB_1 PF05184.15 CDW61119.1 - 0.00039 20.4 0.5 0.00039 20.4 0.5 2.4 2 0 0 2 2 2 1 Saposin-like type B, region 1 SapB_2 PF03489.17 CDW61119.1 - 0.0024 18.0 0.3 0.037 14.1 0.0 2.8 2 0 0 2 2 2 1 Saposin-like type B, region 2 GIT1_C PF12205.8 CDW61119.1 - 0.049 13.7 0.1 0.064 13.4 0.1 1.3 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Casc1_N PF15927.5 CDW61119.1 - 0.15 11.8 0.1 0.17 11.5 0.1 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus SSF PF00474.17 CDW61120.1 - 8.1e-10 38.1 4.5 1e-09 37.8 4.5 1.1 1 0 0 1 1 1 1 Sodium:solute symporter family Glyco_hydro_18 PF00704.28 CDW61121.1 - 2.2e-23 83.5 0.5 2.5e-23 83.3 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Motile_Sperm PF00635.26 CDW61122.1 - 6.6e-11 42.0 0.0 1.2e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain zf-C2H2 PF00096.26 CDW61123.1 - 5e-30 102.3 52.8 0.00011 22.4 0.4 10.1 9 1 1 10 10 10 7 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CDW61123.1 - 3.6e-26 90.4 49.4 8.6e-06 25.9 0.8 9.0 9 0 0 9 9 9 7 Zinc-finger double domain zf-C2H2_4 PF13894.6 CDW61123.1 - 3.7e-22 77.1 53.8 0.0039 17.9 1.3 10.0 9 1 1 10 10 10 7 C2H2-type zinc finger zf-met PF12874.7 CDW61123.1 - 1e-14 54.3 38.7 0.0011 19.3 0.9 8.9 9 0 0 9 9 9 5 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CDW61123.1 - 1.3e-14 54.0 34.4 0.1 12.9 1.3 8.9 9 0 0 9 9 9 7 Zinc-finger double-stranded RNA-binding Zn-ribbon_8 PF09723.10 CDW61123.1 - 1.3e-07 31.6 29.0 0.0035 17.4 1.1 6.6 5 1 2 7 7 7 3 Zinc ribbon domain CpXC PF14353.6 CDW61123.1 - 2.8e-06 27.3 16.6 1.1 9.4 0.5 5.6 1 1 4 6 6 6 4 CpXC protein zf_UBZ PF18439.1 CDW61123.1 - 1.2e-05 24.8 22.6 4.5 6.9 0.1 8.0 8 0 0 8 8 8 1 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 CDW61123.1 - 9.4e-05 22.3 42.8 0.15 12.1 0.1 9.1 9 0 0 9 9 9 2 C2H2-type zinc finger zf-Di19 PF05605.12 CDW61123.1 - 0.00013 22.2 30.9 0.00031 21.0 2.4 6.0 4 2 1 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding Nudix_N_2 PF14803.6 CDW61123.1 - 0.00054 19.8 13.1 3.6 7.6 0.1 6.2 5 1 0 5 5 5 1 Nudix N-terminal zinc_ribbon_15 PF17032.5 CDW61123.1 - 0.0013 19.4 20.7 0.89 10.3 0.6 4.6 1 1 5 6 6 6 3 zinc-ribbon family HypA PF01155.19 CDW61123.1 - 0.0024 17.8 17.8 0.48 10.5 2.2 4.5 1 1 3 4 4 4 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.14 CDW61123.1 - 0.0025 17.8 19.1 0.58 10.2 0.3 5.9 3 3 2 5 5 5 2 Adenylate kinase, active site lid zf-C2H2_11 PF16622.5 CDW61123.1 - 0.0074 16.0 0.3 0.0074 16.0 0.3 7.7 9 0 0 9 9 8 1 zinc-finger C2H2-type DZR PF12773.7 CDW61123.1 - 0.036 14.1 22.4 8.7 6.5 6.7 5.1 1 1 1 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 CDW61123.1 - 0.052 13.5 1.3 0.052 13.5 1.3 5.8 4 2 1 5 5 5 0 Transposase zinc-ribbon domain zf-LYAR PF08790.11 CDW61123.1 - 0.075 13.0 23.9 15 5.6 0.2 7.3 7 0 0 7 7 7 0 LYAR-type C2HC zinc finger PRY PF13765.6 CDW61123.1 - 0.077 12.6 0.1 0.84 9.3 0.0 2.7 3 0 0 3 3 2 0 SPRY-associated domain zf-C2H2_2 PF12756.7 CDW61123.1 - 0.087 13.2 31.0 13 6.2 0.2 7.7 2 2 4 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-WRNIP1_ubi PF18279.1 CDW61123.1 - 0.094 13.4 0.5 2 9.2 0.1 3.1 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-C2H2_3rep PF18868.1 CDW61123.1 - 0.11 13.1 26.6 11 6.7 0.9 6.3 2 1 2 5 5 4 0 Zinc finger C2H2-type, 3 repeats PriA_CRR PF18319.1 CDW61123.1 - 0.16 12.0 0.1 0.16 12.0 0.1 5.3 8 0 0 8 8 4 0 PriA DNA helicase Cys-rich region (CRR) domain DUF1364 PF07102.12 CDW61123.1 - 0.22 11.4 7.0 6 6.8 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1364) zinc-ribbons_6 PF07191.12 CDW61123.1 - 0.29 11.2 23.7 10 6.2 4.9 5.7 2 2 1 4 4 4 0 zinc-ribbons zf-nanos PF05741.13 CDW61123.1 - 0.35 11.1 0.2 0.35 11.1 0.2 6.0 6 2 0 6 6 4 0 Nanos RNA binding domain Mut7-C PF01927.16 CDW61123.1 - 0.56 10.3 19.4 0.47 10.6 0.2 4.8 1 1 4 5 5 5 0 Mut7-C RNAse domain zf-AN1 PF01428.16 CDW61123.1 - 0.81 9.9 33.5 1.6 9.0 0.4 8.7 9 0 0 9 9 9 0 AN1-like Zinc finger Zn-C2H2_12 PF18112.1 CDW61123.1 - 0.95 10.0 0.1 0.95 10.0 0.1 5.9 7 0 0 7 7 5 0 Autophagy receptor zinc finger-C2H2 domain zf-Sec23_Sec24 PF04810.15 CDW61123.1 - 1.1 9.4 31.0 2.3 8.4 0.4 8.4 9 0 0 9 9 9 0 Sec23/Sec24 zinc finger T4_baseplate PF12322.8 CDW61123.1 - 2.4 7.6 5.5 8.6 5.8 0.0 3.7 3 1 2 5 5 5 0 T4 bacteriophage base plate protein DUF3268 PF11672.8 CDW61123.1 - 4.7 7.6 14.9 1.3 9.4 1.2 3.9 4 1 1 5 5 4 0 zinc-finger-containing domain Zn_Tnp_IS1 PF03811.13 CDW61123.1 - 8 6.3 8.7 49 3.8 0.2 4.3 3 0 0 3 3 3 0 InsA N-terminal domain zf-CSL PF05207.13 CDW61123.1 - 10 6.0 15.0 0.71 9.6 0.2 4.3 5 0 0 5 5 4 0 CSL zinc finger EGF_2 PF07974.13 CDW61124.1 - 4.9e-07 30.0 7.7 4.9e-07 30.0 7.7 2.5 2 0 0 2 2 2 1 EGF-like domain DUF2448 PF10476.9 CDW61124.1 - 0.011 15.6 0.1 0.016 15.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) hEGF PF12661.7 CDW61124.1 - 0.044 14.4 5.5 0.044 14.4 5.5 2.6 2 0 0 2 2 2 0 Human growth factor-like EGF EB PF01683.18 CDW61124.1 - 0.81 10.0 11.7 8.9 6.7 11.8 2.2 1 1 0 1 1 1 0 EB module I-EGF_1 PF18372.1 CDW61124.1 - 5.1 7.3 14.4 2.5 8.3 0.9 3.4 3 0 0 3 3 3 0 Integrin beta epidermal growth factor like domain 1 PGM_PMM_I PF02878.16 CDW61125.1 - 2.3e-22 79.2 0.1 3e-22 78.8 0.1 1.1 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Peptidase_M9 PF01752.17 CDW61125.1 - 0.14 11.4 0.0 0.19 11.0 0.0 1.1 1 0 0 1 1 1 0 Collagenase Sua5_yciO_yrdC PF01300.18 CDW61126.1 - 1.8e-34 118.8 0.0 2.1e-34 118.6 0.0 1.0 1 0 0 1 1 1 1 Telomere recombination Peptidase_M13 PF01431.21 CDW61127.1 - 1.5e-72 243.5 1.2 1.5e-72 243.5 1.2 1.7 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13_N PF05649.13 CDW61127.1 - 2.5e-18 66.9 0.8 2.5e-18 66.9 0.8 1.8 2 0 0 2 2 2 1 Peptidase family M13 Dimer_Tnp_hAT PF05699.14 CDW61128.1 - 0.00049 19.8 0.4 0.004 16.9 0.1 2.0 1 1 1 2 2 2 1 hAT family C-terminal dimerisation region CBP_BcsF PF11120.8 CDW61128.1 - 0.12 12.5 0.7 1.6 8.9 0.0 2.5 2 1 1 3 3 3 0 Cellulose biosynthesis protein BcsF Zn_Tnp_IS91 PF14319.6 CDW61129.1 - 9.2e-16 57.7 1.0 1e-15 57.5 1.0 1.0 1 0 0 1 1 1 1 Transposase zinc-binding domain StbA PF06406.11 CDW61131.1 - 3.8e-158 525.8 1.0 4.2e-158 525.6 1.0 1.0 1 0 0 1 1 1 1 StbA protein Hydantoinase_A PF01968.18 CDW61131.1 - 0.00021 20.7 0.8 0.013 14.8 0.1 2.7 2 1 0 3 3 3 1 Hydantoinase/oxoprolinase DUF4852 PF16144.5 CDW61131.1 - 0.026 14.6 0.1 0.088 12.9 0.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4852) MutL PF13941.6 CDW61131.1 - 0.061 11.9 0.1 0.082 11.5 0.1 1.3 1 0 0 1 1 1 0 MutL protein SID-1_RNA_chan PF13965.6 CDW61132.1 - 1.6e-48 165.5 3.8 1.8e-48 165.4 3.8 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 UPF0542 PF15086.6 CDW61132.1 - 0.015 15.2 4.2 0.78 9.7 0.2 2.5 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 Ceramidase PF05875.12 CDW61132.1 - 0.042 13.3 0.7 0.066 12.6 0.7 1.3 1 0 0 1 1 1 0 Ceramidase Oxidored_q3 PF00499.20 CDW61132.1 - 0.12 12.1 3.6 0.32 10.7 4.0 1.5 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 CAP PF00188.26 CDW61134.1 - 1.5e-07 32.3 2.0 2.9e-07 31.4 2.0 1.5 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CRAL_TRIO PF00650.20 CDW61137.1 - 3.6e-12 46.3 0.0 5.6e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Pkinase PF00069.25 CDW61138.1 - 1.5e-18 67.1 0.0 1.9e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW61138.1 - 8.7e-13 48.1 0.0 1e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase JmjC PF02373.22 CDW61138.1 - 0.082 13.3 0.0 0.18 12.3 0.0 1.6 1 0 0 1 1 1 0 JmjC domain, hydroxylase Motile_Sperm PF00635.26 CDW61139.1 - 1.3e-10 41.1 0.0 3e-10 39.9 0.0 1.6 2 0 0 2 2 2 1 MSP (Major sperm protein) domain ABC_tran PF00005.27 CDW61141.1 - 6.5e-22 78.5 0.0 1.1e-21 77.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CDW61141.1 - 5.9e-13 49.3 0.3 2.1e-06 27.8 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 CDW61141.1 - 5e-09 36.1 2.8 6.4e-09 35.7 0.4 2.3 3 0 0 3 3 3 1 ABC transporter AAA_15 PF13175.6 CDW61141.1 - 9e-05 22.3 0.0 0.0057 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 CDW61141.1 - 0.00015 21.3 0.0 0.32 10.4 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CDW61141.1 - 0.0095 16.5 0.7 0.015 15.8 0.1 1.6 2 0 0 2 2 1 1 AAA domain AAA_30 PF13604.6 CDW61141.1 - 0.022 14.5 0.0 0.06 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CDW61141.1 - 0.022 15.3 0.0 0.037 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 CDW61141.1 - 0.025 15.0 0.0 0.067 13.6 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CDW61141.1 - 0.028 14.1 0.0 0.068 12.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.8 CDW61141.1 - 0.034 11.7 0.2 0.051 11.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_29 PF13555.6 CDW61141.1 - 0.041 13.6 0.0 0.094 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CDW61141.1 - 0.047 13.9 0.0 0.093 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CDW61141.1 - 0.058 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 CDW61141.1 - 0.11 12.4 0.1 0.63 9.9 0.1 2.0 1 1 1 2 2 2 0 NTPase AAA_22 PF13401.6 CDW61141.1 - 0.12 12.7 0.1 0.27 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 CDW61141.1 - 0.14 12.0 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 NACHT domain Galactosyl_T PF01762.21 CDW61142.1 - 7.2e-52 176.0 0.0 9.5e-52 175.7 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Nucleo_P87 PF07267.11 CDW61144.1 - 4.3 6.1 5.8 5.6 5.7 5.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MRP-S23 PF10484.9 CDW61146.1 - 6e-37 126.8 0.0 6.9e-37 126.6 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S23 MRP-S25 PF13741.6 CDW61146.1 - 0.0014 18.2 1.7 0.068 12.7 0.0 2.2 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 Connexin PF00029.19 CDW61148.1 - 0.0062 16.3 0.3 0.012 15.4 0.3 1.6 1 1 0 1 1 1 1 Connexin MAP17 PF15807.5 CDW61148.1 - 0.044 14.0 2.1 0.082 13.1 2.1 1.5 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Phage_Gp23 PF10669.9 CDW61148.1 - 0.069 13.5 0.1 0.069 13.5 0.1 1.6 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Presenilin PF01080.17 CDW61148.1 - 0.1 11.3 0.5 0.12 11.1 0.5 1.2 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 CDW61148.1 - 0.11 11.5 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 CLN3 protein Ycf1 PF05758.12 CDW61148.1 - 0.44 8.3 1.7 0.47 8.2 1.7 1.0 1 0 0 1 1 1 0 Ycf1 DUF1758 PF05585.12 CDW61149.1 - 0.00011 22.0 0.0 0.00021 21.1 0.0 1.5 1 1 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 CDW61149.1 - 0.00074 20.1 0.0 0.0019 18.8 0.0 1.7 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW61149.1 - 0.0031 18.1 0.0 0.016 15.8 0.0 2.2 1 1 0 1 1 1 1 gag-polyprotein putative aspartyl protease EF-hand_6 PF13405.6 CDW61150.1 - 9.1e-11 40.8 0.1 0.00039 20.1 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 CDW61150.1 - 1.1e-09 38.6 0.0 0.00016 22.0 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CDW61150.1 - 1.2e-09 37.0 0.0 7.5e-05 22.0 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 CDW61150.1 - 4e-06 26.6 0.0 0.00052 19.8 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 CDW61150.1 - 4.1e-05 23.8 0.0 0.00036 20.8 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 CDW61150.1 - 0.058 12.9 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 EF hand Ribo_biogen_C PF04034.13 CDW61151.1 - 6.2e-51 171.4 0.0 8.3e-51 171.0 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CDW61151.1 - 2.3e-07 30.5 0.5 6.4e-07 29.1 0.5 1.8 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SR-25 PF10500.9 CDW61151.1 - 5.9e-05 22.8 27.7 0.0018 18.0 12.1 2.1 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein IMUP PF15761.5 CDW61151.1 - 0.062 14.0 6.8 0.062 14.0 6.8 3.1 2 1 0 2 2 2 0 Immortalisation up-regulated protein Dehydrin PF00257.19 CDW61151.1 - 0.1 13.2 0.1 0.1 13.2 0.1 2.4 2 0 0 2 2 2 0 Dehydrin DUF4685 PF15737.5 CDW61151.1 - 0.23 11.9 0.2 0.23 11.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) Pap_E4 PF02711.14 CDW61151.1 - 4.5 8.3 7.8 18 6.3 2.3 2.4 2 0 0 2 2 2 0 E4 protein DUF445 PF04286.12 CDW61152.1 - 0.018 14.9 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) GAD PF02938.14 CDW61152.1 - 0.049 13.9 0.0 0.059 13.6 0.0 1.1 1 0 0 1 1 1 0 GAD domain DZF PF07528.14 CDW61153.1 - 0.00051 19.8 0.0 0.00071 19.3 0.0 1.1 1 0 0 1 1 1 1 DZF domain VioE PF18234.1 CDW61153.1 - 0.18 11.9 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Violacein biosynthetic enzyme VioE Pou PF00157.17 CDW61155.1 - 2.7e-30 104.1 0.1 4.9e-30 103.3 0.1 1.4 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain DUF1759 PF03564.15 CDW61156.1 - 3e-27 95.4 0.0 4.5e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) DUF1758 PF05585.12 CDW61156.1 - 6.7e-09 35.7 0.0 1.5e-08 34.6 0.0 1.5 1 1 0 1 1 1 1 Putative peptidase (DUF1758) Histone PF00125.24 CDW61157.1 - 3e-18 66.5 0.3 3.3e-18 66.3 0.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CDW61157.1 - 1.4e-05 25.3 1.4 2.9e-05 24.2 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF1931 PF09123.11 CDW61157.1 - 0.008 16.3 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1931) TFIID_20kDa PF03847.13 CDW61157.1 - 0.013 16.0 0.0 0.018 15.5 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 CDW61157.1 - 0.016 15.3 0.1 0.018 15.0 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein DUF1759 PF03564.15 CDW61158.1 - 0.0017 18.3 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) PDEase_I PF00233.19 CDW61159.1 - 8.3e-31 107.5 6.4 8.3e-20 71.5 6.4 3.1 1 1 1 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase FF PF01846.19 CDW61160.1 - 6.8e-10 39.0 0.1 1.6e-07 31.4 0.0 2.4 2 0 0 2 2 2 2 FF domain CNOT1_HEAT PF16418.5 CDW61160.1 - 0.0042 17.2 0.7 0.0042 17.2 0.7 1.5 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat FKBP_N PF01346.18 CDW61160.1 - 6.2 7.9 7.3 2.9 8.9 1.1 2.1 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Ribosomal_L36e PF01158.18 CDW61161.1 - 2.5e-40 136.6 7.0 2.8e-40 136.5 7.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Trypsin PF00089.26 CDW61162.1 - 1.4e-08 34.8 0.0 5.6e-08 32.9 0.0 1.8 2 0 0 2 2 2 1 Trypsin Proton_antipo_M PF00361.20 CDW61165.1 - 0.00053 19.3 0.0 0.0018 17.6 0.0 1.6 1 1 1 2 2 2 1 Proton-conducting membrane transporter RVT_1 PF00078.27 CDW61166.1 - 0.00017 21.2 0.0 0.0002 21.0 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Serpin PF00079.20 CDW61167.1 - 7.1e-84 282.2 4.5 8.1e-84 282.0 4.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 CDW61168.1 - 5.4e-35 121.4 0.0 5.7e-35 121.3 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) OST3_OST6 PF04756.13 CDW61168.1 - 0.049 13.0 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family SCAB-PH PF17684.1 CDW61168.1 - 0.072 13.3 0.0 0.099 12.9 0.0 1.2 1 0 0 1 1 1 0 PH domain of plant-specific actin-binding protein DnaJ PF00226.31 CDW61169.1 - 2.9e-28 97.8 4.9 4.4e-28 97.2 4.9 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CDW61169.1 - 1.8e-10 41.0 13.1 3.2e-10 40.2 13.1 1.4 1 0 0 1 1 1 1 DnaJ central domain DnaJ_C PF01556.18 CDW61169.1 - 2.9e-06 27.4 0.0 4.5e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain Anti-TRAP PF15777.5 CDW61169.1 - 0.019 14.9 16.4 1.7 8.6 2.9 3.6 1 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 CDW61169.1 - 0.71 10.1 21.2 3.5 7.9 1.0 4.4 4 0 0 4 4 4 0 Family of unknown function (DUF5351) HypA PF01155.19 CDW61169.1 - 3.1 7.8 8.5 0.82 9.7 0.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2922 PF11148.8 CDW61170.1 - 0.0047 16.6 0.0 0.0072 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) DUF1343 PF07075.11 CDW61170.1 - 0.13 11.6 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1343) EGF PF00008.27 CDW61171.1 - 7.4e-34 115.7 105.1 1.1e-05 25.7 5.8 8.7 8 0 0 8 8 8 8 EGF-like domain EGF_CA PF07645.15 CDW61171.1 - 4.6e-32 109.9 116.8 9.7e-09 35.3 9.8 8.4 6 2 2 8 8 8 6 Calcium-binding EGF domain EGF_2 PF07974.13 CDW61171.1 - 9.1e-21 73.9 127.1 0.0011 19.2 11.4 8.4 8 0 0 8 8 8 8 EGF-like domain hEGF PF12661.7 CDW61171.1 - 8.3e-20 70.7 91.4 0.0019 18.8 7.7 9.5 8 1 0 8 8 8 7 Human growth factor-like EGF EGF_3 PF12947.7 CDW61171.1 - 1.9e-11 43.9 105.7 0.00071 19.7 9.6 8.7 8 1 0 8 8 8 5 EGF domain FXa_inhibition PF14670.6 CDW61171.1 - 1.1e-06 28.8 90.3 0.019 15.2 8.9 8.6 4 3 4 8 8 8 6 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW61171.1 - 1.7e-05 24.7 81.7 0.0053 16.7 1.6 8.8 8 0 0 8 8 8 6 Complement Clr-like EGF-like Laminin_EGF PF00053.24 CDW61171.1 - 0.0048 17.0 98.9 0.033 14.3 1.4 8.4 3 2 5 8 8 8 5 Laminin EGF domain ERCC3_RAD25_C PF16203.5 CDW61176.1 - 0.0045 16.2 1.1 0.0048 16.1 0.6 1.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Beta-TrCP_D PF12125.8 CDW61176.1 - 0.093 12.6 0.2 0.51 10.3 0.1 1.9 2 0 0 2 2 2 0 D domain of beta-TrCP ERCC3_RAD25_C PF16203.5 CDW61177.1 - 6.2e-63 212.3 1.1 6.5e-63 212.2 1.1 1.0 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C PF00271.31 CDW61177.1 - 6.1e-11 42.6 0.0 1.1e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain gag-asp_proteas PF13975.6 CDW61179.1 - 2.3e-06 28.1 0.1 4.7e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW61179.1 - 1.2e-05 25.8 0.0 2.3e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 CDW61179.1 - 0.0003 20.5 1.0 0.0006 19.6 1.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease zf-CCHC PF00098.23 CDW61179.1 - 0.12 12.5 0.3 0.23 11.6 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle Asp_protease PF09668.10 CDW61179.1 - 0.27 11.0 0.9 1.4 8.8 0.9 2.0 1 1 0 1 1 1 0 Aspartyl protease Sugarporin_N PF11471.8 CDW61180.1 - 0.051 13.5 0.1 0.099 12.6 0.0 1.6 1 1 0 1 1 1 0 Maltoporin periplasmic N-terminal extension GWT1 PF06423.12 CDW61181.1 - 9e-05 22.6 0.3 0.0006 19.9 0.1 2.2 1 1 1 2 2 2 1 GWT1 LSM PF01423.22 CDW61183.1 - 2.9e-20 71.7 0.2 3.3e-20 71.5 0.2 1.0 1 0 0 1 1 1 1 LSM domain RNase_Zc3h12a PF11977.8 CDW61184.1 - 3e-06 27.1 0.0 7e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain SURF1 PF02104.15 CDW61186.1 - 2.4e-05 24.7 0.0 2.5e-05 24.6 0.0 1.0 1 0 0 1 1 1 1 SURF1 family YqzL PF14006.6 CDW61188.1 - 0.45 10.9 3.2 0.96 9.9 0.0 2.5 2 1 0 2 2 2 0 YqzL-like protein DUF1660 PF07874.11 CDW61188.1 - 0.58 10.7 2.4 1.5 9.4 2.4 1.7 1 1 0 1 1 1 0 Prophage protein (DUF1660) Peptidase_M1_N PF17900.1 CDW61189.1 - 6e-41 140.7 0.0 7.3e-41 140.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain fn3_2 PF16893.5 CDW61189.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.8 2 0 0 2 2 2 0 Fibronectin type III domain zf-Tim10_DDP PF02953.15 CDW61190.1 - 1.1e-14 53.8 0.6 1.5e-14 53.3 0.6 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger IL10 PF00726.17 CDW61190.1 - 0.034 13.6 0.2 0.041 13.4 0.2 1.2 1 0 0 1 1 1 0 Interleukin 10 LXG PF04740.12 CDW61191.1 - 1.8e-12 47.4 7.0 1.8e-12 47.4 7.0 4.3 3 2 2 5 5 5 1 LXG domain of WXG superfamily DUF4176 PF13780.6 CDW61191.1 - 1e-09 38.2 0.1 3.6e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4176) DUF5082 PF16888.5 CDW61191.1 - 9.3e-08 32.4 9.1 9.3e-08 32.4 9.1 3.8 3 2 1 4 4 4 1 Domain of unknown function (DUF5082) DUF3338 PF11819.8 CDW61191.1 - 0.0042 17.1 1.2 0.0042 17.1 1.2 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3338) SidE PF12252.8 CDW61191.1 - 0.0067 14.0 5.8 0.011 13.3 5.8 1.3 1 0 0 1 1 1 1 Dot/Icm substrate protein Baculo_PEP_C PF04513.12 CDW61191.1 - 0.019 15.0 6.3 10 6.1 0.0 3.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Polysacc_deac_2 PF04748.13 CDW61191.1 - 0.05 12.8 0.6 0.44 9.7 0.1 2.5 2 0 0 2 2 2 0 Divergent polysaccharide deacetylase WXG100 PF06013.12 CDW61191.1 - 0.2 11.9 0.1 0.2 11.9 0.1 5.1 5 2 1 6 6 6 0 Proteins of 100 residues with WXG Clusterin PF01093.17 CDW61191.1 - 0.59 9.1 13.4 0.43 9.6 2.3 2.2 2 0 0 2 2 2 0 Clusterin H-kinase_dim PF02895.14 CDW61191.1 - 1.1 9.7 7.3 4.6 7.7 0.6 3.4 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain DUF1664 PF07889.12 CDW61191.1 - 9.6 6.3 16.2 0.17 11.9 1.2 4.1 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) 7tm_1 PF00001.21 CDW61192.1 - 1.1e-11 44.6 1.8 1.6e-11 44.1 1.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) T3SS_needle_F PF09392.10 CDW61192.1 - 0.089 13.0 0.9 0.16 12.2 0.9 1.3 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF WD40 PF00400.32 CDW61193.1 - 4.2e-05 24.2 0.6 0.0083 17.0 0.0 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat HTH_Tnp_Tc5 PF03221.16 CDW61195.1 - 1.4e-09 37.8 0.1 2.9e-09 36.8 0.1 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 CDW61195.1 - 3.9e-08 32.8 3.7 8.5e-08 31.7 3.7 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 CDW61195.1 - 0.022 14.6 0.2 0.055 13.3 0.2 1.7 1 0 0 1 1 1 0 Homeodomain-like domain Sulphotransf PF09037.10 CDW61195.1 - 0.055 13.0 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Stf0 sulphotransferase Spore_III_AB PF09548.10 CDW61195.1 - 0.11 12.6 1.2 1 9.4 1.0 2.4 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Pkinase PF00069.25 CDW61199.1 - 3.5e-27 95.4 0.1 4.1e-27 95.2 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW61199.1 - 4.5e-16 58.9 0.1 5.4e-16 58.6 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW61199.1 - 8e-05 21.7 0.0 0.0001 21.4 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 CDW61199.1 - 0.037 13.6 0.1 0.045 13.3 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 CDW61199.1 - 0.15 10.8 0.0 0.22 10.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CDW61199.1 - 0.2 11.6 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Histone PF00125.24 CDW61200.1 - 3.8e-50 169.6 4.5 4.2e-50 169.5 4.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 CDW61200.1 - 4.3e-05 24.1 1.1 5.1e-05 23.9 1.1 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 CDW61200.1 - 8.6e-05 22.6 0.1 8.6e-05 22.6 0.1 1.8 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CDW61200.1 - 0.0017 18.7 0.1 0.0027 18.0 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CDW61200.1 - 0.013 15.5 0.1 0.032 14.3 0.0 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CBFD_NFYB_HMF PF00808.23 CDW61200.1 - 0.058 13.7 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-CCHC PF00098.23 CDW61201.1 - 9.1e-08 31.8 1.2 1.4e-07 31.2 1.2 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_4 PF14392.6 CDW61201.1 - 0.017 14.8 1.6 0.02 14.6 0.3 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 CDW61201.1 - 0.027 14.3 0.4 0.051 13.4 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 CDW61201.1 - 0.045 13.6 2.4 0.087 12.7 2.4 1.4 1 0 0 1 1 1 0 Zinc knuckle Carboxyl_trans PF01039.22 CDW61202.1 - 5.5e-77 259.5 0.0 6.3e-77 259.3 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 CDW61202.1 - 0.0034 16.9 0.1 0.005 16.4 0.1 1.2 1 0 0 1 1 1 1 Malonate decarboxylase gamma subunit (MdcE) DUF4371 PF14291.6 CDW61204.1 - 7.1e-05 22.6 0.0 7.5e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4371) VWA_3 PF13768.6 CDW61204.1 - 0.02 14.9 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain FlgN PF05130.12 CDW61205.1 - 0.0045 17.5 2.8 0.0097 16.4 2.8 1.4 1 0 0 1 1 1 1 FlgN protein CREPT PF16566.5 CDW61205.1 - 0.026 14.7 1.0 0.055 13.6 1.0 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Sec34 PF04136.15 CDW61205.1 - 0.22 11.4 3.4 0.11 12.3 1.4 1.5 2 0 0 2 2 2 0 Sec34-like family FTSW_RODA_SPOVE PF01098.19 CDW61207.1 - 6.2e-32 111.0 0.5 6.9e-32 110.8 0.5 1.0 1 0 0 1 1 1 1 Cell cycle protein HepII_C PF18675.1 CDW61208.1 - 0.064 13.4 0.0 0.082 13.0 0.0 1.3 1 0 0 1 1 1 0 Heparinase II C-terminal domain Exo_endo_phos PF03372.23 CDW61209.1 - 1.2e-07 31.5 0.1 1.4e-07 31.3 0.1 1.0 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MRI PF15325.6 CDW61211.1 - 8.3 7.6 7.5 8 7.6 0.3 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection Bactofilin PF04519.13 CDW61212.1 - 7e-05 23.1 1.9 0.00029 21.1 1.9 2.1 1 1 0 1 1 1 1 Polymer-forming cytoskeletal Trypsin PF00089.26 CDW61213.1 - 2.2e-12 47.2 0.0 4.9e-12 46.1 0.0 1.5 1 1 0 1 1 1 1 Trypsin Hist_deacetyl PF00850.19 CDW61215.1 - 2.3e-09 37.2 0.0 2.8e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Ank_4 PF13637.6 CDW61218.1 - 2e-15 56.9 0.4 8.4e-10 39.0 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CDW61218.1 - 9.8e-14 51.2 0.1 2e-11 43.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CDW61218.1 - 1.9e-12 47.6 0.2 1.2e-11 45.0 0.2 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CDW61218.1 - 8.1e-11 41.9 0.8 5.9e-05 23.3 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CDW61218.1 - 5.4e-10 38.7 0.9 0.00034 20.8 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat tRNA-synt_1c PF00749.21 CDW61219.1 - 9.8e-26 90.4 0.8 1.1e-25 90.3 0.8 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1e PF01406.19 CDW61219.1 - 0.0021 17.4 0.0 0.0025 17.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Motile_Sperm PF00635.26 CDW61220.1 - 1.7e-11 43.9 0.1 4.9e-11 42.5 0.0 1.7 2 0 0 2 2 2 1 MSP (Major sperm protein) domain DUF963 PF06131.11 CDW61223.1 - 0.021 14.2 1.4 0.04 13.3 1.4 1.5 1 0 0 1 1 1 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Retrotrans_gag PF03732.17 CDW61226.1 - 0.012 15.9 0.0 0.037 14.3 0.0 1.9 1 1 0 1 1 1 0 Retrotransposon gag protein NUDIX PF00293.28 CDW61229.1 - 0.0033 17.5 0.0 0.012 15.7 0.0 1.9 1 1 0 1 1 1 1 NUDIX domain Thioredoxin_8 PF13905.6 CDW61230.1 - 0.014 15.7 1.2 0.036 14.4 0.2 2.3 2 0 0 2 2 2 0 Thioredoxin-like Bax1-I PF01027.20 CDW61231.1 - 2.5e-08 34.0 0.3 3e-08 33.8 0.3 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 TauE PF01925.19 CDW61231.1 - 0.00073 19.2 0.2 0.00081 19.1 0.2 1.1 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Neurensin PF14927.6 CDW61231.1 - 0.051 13.3 0.1 0.15 11.8 0.0 1.7 1 1 1 2 2 2 0 Neurensin MotA_ExbB PF01618.16 CDW61231.1 - 0.076 12.8 0.0 0.28 10.9 0.0 1.8 1 1 1 2 2 2 0 MotA/TolQ/ExbB proton channel family zf-H2C2_2 PF13465.6 CDW61232.1 - 0.099 13.1 1.0 0.099 13.1 1.0 3.5 4 0 0 4 4 4 0 Zinc-finger double domain Actin_micro PF17003.5 CDW61232.1 - 0.34 10.0 2.1 0.9 8.6 2.1 1.7 1 1 0 1 1 1 0 Putative actin-like family TruB_N PF01509.18 CDW61233.1 - 0.025 15.0 0.0 0.027 14.8 0.0 1.1 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Integrase_H2C2 PF17921.1 CDW61234.1 - 3.2e-18 65.6 0.1 6.6e-18 64.6 0.1 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 CDW61234.1 - 4.6e-09 36.5 0.1 4.6e-08 33.3 0.1 2.3 1 1 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 CDW61234.1 - 1.1e-05 25.5 0.0 2.6e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Phage_TAC_10 PF10963.8 CDW61234.1 - 0.14 12.3 0.0 0.47 10.7 0.0 1.8 1 0 0 1 1 1 0 Phage tail assembly chaperone DUF1758 PF05585.12 CDW61235.1 - 2.5e-13 50.1 0.0 4e-13 49.5 0.0 1.3 1 1 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 CDW61235.1 - 0.041 14.5 0.0 0.075 13.7 0.0 1.5 1 0 0 1 1 1 0 Aspartyl protease Integrase_H2C2 PF17921.1 CDW61236.1 - 2.5e-08 33.9 0.4 5.9e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain RNase_Zc3h12a PF11977.8 CDW61238.1 - 4e-07 29.9 0.0 8.6e-07 28.9 0.0 1.6 1 1 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain SAM_PNT PF02198.16 CDW61239.1 - 0.0018 18.2 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain DUF1347 PF07079.11 CDW61239.1 - 0.03 12.9 0.0 0.035 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) SAM_3 PF18016.1 CDW61239.1 - 0.15 11.9 0.1 0.41 10.5 0.1 1.8 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Trypsin PF00089.26 CDW61240.1 - 1.8e-15 57.3 1.0 2.8e-15 56.8 1.0 1.3 1 0 0 1 1 1 1 Trypsin E1-E2_ATPase PF00122.20 CDW61242.1 - 3.2e-37 127.8 13.1 3.4e-29 101.6 2.0 3.1 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 CDW61242.1 - 1.4e-14 53.5 0.0 3.2e-14 52.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus MLANA PF14991.6 CDW61242.1 - 0.11 12.7 2.0 0.3 11.4 0.0 2.5 2 1 1 3 3 3 0 Protein melan-A DUF4231 PF14015.6 CDW61242.1 - 0.59 10.6 0.0 0.59 10.6 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) AATF-Che1 PF13339.6 CDW61243.1 - 3.3e-21 76.4 3.8 4.5e-21 76.0 0.9 2.3 2 0 0 2 2 2 1 Apoptosis antagonizing transcription factor Rab5-bind PF09311.11 CDW61243.1 - 0.0011 18.5 6.2 0.0062 16.0 6.2 1.9 1 1 0 1 1 1 1 Rabaptin-like protein Nfu_N PF08712.11 CDW61244.1 - 3.5e-31 107.1 0.2 8e-31 106.0 0.0 1.7 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 CDW61244.1 - 1.7e-28 98.6 0.1 3.2e-28 97.7 0.1 1.5 1 0 0 1 1 1 1 NifU-like domain DUF5641 PF18701.1 CDW61248.1 - 3.9e-18 65.4 0.0 5.6e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5641) tRNA-synt_1c_C PF03950.18 CDW61250.1 - 1.1e-31 110.1 0.1 1.7e-31 109.4 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain CBX7_C PF17218.3 CDW61250.1 - 0.1 12.3 0.6 0.27 11.0 0.6 1.8 1 0 0 1 1 1 0 CBX family C-terminal motif CholecysA-Rec_N PF09193.10 CDW61250.1 - 0.2 11.7 0.9 5.2 7.1 0.1 2.8 3 0 0 3 3 3 0 Cholecystokinin A receptor, N-terminal zf-CCHC PF00098.23 CDW61252.1 - 0.0017 18.4 0.9 0.0017 18.4 0.9 2.0 2 0 0 2 2 2 1 Zinc knuckle Retrotrans_gag PF03732.17 CDW61252.1 - 0.037 14.3 0.0 0.13 12.5 0.0 1.9 1 1 1 2 2 2 0 Retrotransposon gag protein YhfH PF14149.6 CDW61252.1 - 0.044 13.8 1.5 5.8 7.0 0.0 2.5 2 0 0 2 2 2 0 YhfH-like protein zf-CCHC_6 PF15288.6 CDW61252.1 - 0.21 11.4 5.9 0.44 10.4 1.0 2.4 1 1 1 2 2 2 0 Zinc knuckle Antirestrict PF03230.13 CDW61254.1 - 1.4e-26 92.3 0.0 1.8e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Antirestriction protein RVT_1 PF00078.27 CDW61255.1 - 0.063 12.8 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) DUF1758 PF05585.12 CDW61256.1 - 7.3e-10 38.9 0.0 2.3e-09 37.2 0.0 1.8 1 1 0 1 1 1 1 Putative peptidase (DUF1758) Asp_protease_2 PF13650.6 CDW61256.1 - 0.096 13.3 0.0 0.22 12.2 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease TYW3 PF02676.14 CDW61257.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase TYW3 Motile_Sperm PF00635.26 CDW61262.1 - 1.3e-10 41.1 0.0 2.3e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain CAMSAP_CKK PF08683.11 CDW61263.1 - 8.1e-06 26.0 2.3 0.39 10.9 0.0 4.5 5 0 0 5 5 5 3 Microtubule-binding calmodulin-regulated spectrin-associated Stevor PF17410.2 CDW61263.1 - 0.0027 17.3 0.1 51 3.3 0.0 4.1 4 0 0 4 4 4 0 Subtelomeric Variable Open Reading frame ETF_alpha PF00766.19 CDW61263.1 - 0.0054 16.7 3.6 71 3.5 0.0 4.2 4 0 0 4 4 4 0 Electron transfer flavoprotein FAD-binding domain DUF3926 PF13080.6 CDW61263.1 - 0.015 15.2 0.0 1.7e+02 2.2 0.0 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF3926) Flavodoxin_5 PF12724.7 CDW61263.1 - 0.04 14.2 0.0 1.4e+02 2.6 0.0 4.0 4 0 0 4 4 4 0 Flavodoxin domain DnaJ PF00226.31 CDW61265.1 - 4.3e-06 26.8 0.6 2.1e-05 24.5 0.6 1.9 1 1 0 1 1 1 1 DnaJ domain WD40 PF00400.32 CDW61266.1 - 4.8e-05 24.0 5.5 0.042 14.7 0.1 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat Dicer_dimer PF03368.14 CDW61267.1 - 0.14 12.3 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Dicer dimerisation domain Ribosomal_S28e PF01200.18 CDW61268.1 - 1e-20 73.4 0.3 1.1e-20 73.3 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e rve PF00665.26 CDW61269.1 - 0.024 14.8 0.0 0.035 14.3 0.0 1.2 1 0 0 1 1 1 0 Integrase core domain Ribosomal_L22e PF01776.17 CDW61270.1 - 8.3e-39 132.3 0.2 1e-38 132.1 0.2 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family Trypsin PF00089.26 CDW61271.1 - 0.017 15.0 0.0 0.022 14.6 0.0 1.3 1 1 0 1 1 1 0 Trypsin TAP42 PF04177.12 CDW61272.1 - 2.3e-12 46.7 0.4 2.6e-12 46.5 0.4 1.0 1 0 0 1 1 1 1 TAP42-like family Aminotran_4 PF01063.19 CDW61273.1 - 2.4e-29 102.8 0.0 3.2e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV TK PF00265.18 CDW61274.1 - 1.7e-31 109.5 0.1 2.6e-31 108.8 0.1 1.3 1 0 0 1 1 1 1 Thymidine kinase PseudoU_synth_2 PF00849.22 CDW61274.1 - 1.4e-08 35.0 0.1 2.2e-08 34.4 0.1 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Histone PF00125.24 CDW61275.1 - 1.2e-32 113.0 5.0 1.2e-32 113.0 5.0 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CDW61275.1 - 1.7e-05 24.9 0.1 3.3e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold BRCT_assoc PF12820.7 CDW61275.1 - 0.0078 16.0 2.0 0.011 15.5 2.0 1.3 1 0 0 1 1 1 1 Serine-rich domain associated with BRCT CENP-S PF15630.6 CDW61275.1 - 0.008 16.5 0.1 0.013 15.9 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CDW61275.1 - 0.039 14.2 0.0 0.087 13.1 0.0 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ArsA_HSP20 PF17886.1 CDW61275.1 - 0.057 13.0 0.1 0.12 11.9 0.1 1.6 1 0 0 1 1 1 0 HSP20-like domain found in ArsA EcKinase PF02958.20 CDW61276.1 - 5e-20 72.0 0.0 1.7e-19 70.2 0.0 1.7 1 1 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 CDW61276.1 - 9.6e-20 70.8 0.0 1.1e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.23 CDW61276.1 - 1e-10 41.9 0.0 1.9e-10 41.1 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CDW61276.1 - 0.00015 21.4 0.1 0.00023 20.8 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 CDW61276.1 - 0.11 11.7 0.0 2.3 7.4 0.0 2.2 1 1 0 1 1 1 0 Fructosamine kinase DUF452 PF04301.13 CDW61277.1 - 6.2e-10 38.9 0.6 6.9e-10 38.8 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF452) DDE_Tnp_1 PF01609.21 CDW61278.1 - 5.5e-12 45.8 1.2 3.5e-11 43.2 1.2 2.0 1 1 0 1 1 1 1 Transposase DDE domain DUF2666 PF10869.8 CDW61278.1 - 0.076 13.2 0.0 2.3 8.4 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2666) DUF1759 PF03564.15 CDW61279.1 - 0.11 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Fer4_6 PF12837.7 CDW61279.1 - 5.9 7.1 6.9 18 5.6 6.9 1.8 1 1 0 1 1 1 0 4Fe-4S binding domain Abhydro_lipase PF04083.16 CDW61280.1 - 7.9e-19 67.0 0.0 1.1e-17 63.3 0.0 2.4 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CDW61280.1 - 5.3e-17 62.3 0.8 8.6e-13 48.5 0.3 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CDW61280.1 - 0.00061 19.1 0.1 0.11 11.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CDW61280.1 - 0.031 14.9 0.1 0.055 14.1 0.1 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Homeodomain PF00046.29 CDW61281.1 - 9.1e-21 73.5 2.8 1.3e-20 72.9 2.8 1.3 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 CDW61281.1 - 0.00018 20.9 0.2 0.00079 18.9 0.1 1.9 2 0 0 2 2 2 1 Homeodomain leucine-zipper encoding, Homez DUF3634 PF12321.8 CDW61281.1 - 0.013 15.9 0.0 0.023 15.1 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3634) Homeobox_KN PF05920.11 CDW61281.1 - 0.068 13.1 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Homeobox KN domain Pkinase PF00069.25 CDW61282.1 - 0.00013 21.5 0.0 0.00014 21.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain ATP-synt_G PF04718.15 CDW61283.1 - 8.1e-17 61.9 0.0 1.1e-16 61.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit Glyco_transf_20 PF00982.21 CDW61285.1 - 1.6e-29 103.0 0.0 3.2e-29 102.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 20 T6PP_N PF18572.1 CDW61285.1 - 7.6e-08 32.1 0.1 1.4e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain SH3_4 PF06347.13 CDW61286.1 - 0.077 12.8 0.6 0.14 12.0 0.6 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain LIM PF00412.22 CDW61288.1 - 3.2e-17 62.5 43.0 9.9e-07 28.9 7.3 3.9 3 1 0 3 3 3 3 LIM domain E6 PF00518.17 CDW61288.1 - 4.6 7.7 26.0 1 9.8 9.9 3.8 1 1 1 2 2 2 0 Early Protein (E6) Integrase_H2C2 PF17921.1 CDW61293.1 - 2.5e-06 27.5 0.2 6.4e-06 26.2 0.2 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Peptidase_A17 PF05380.13 CDW61293.1 - 0.00014 21.9 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 Pao retrotransposon peptidase CENP-F_C_Rb_bdg PF10490.9 CDW61293.1 - 0.023 14.1 0.1 2.5 7.6 0.0 3.1 3 0 0 3 3 3 0 Rb-binding domain of kinetochore protein Cenp-F/LEK1 Orf78 PF06024.12 CDW61295.1 - 0.018 15.4 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF948 PF06103.11 CDW61295.1 - 0.25 11.6 2.2 0.56 10.5 2.2 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Calcyon PF06387.11 CDW61295.1 - 0.29 11.1 2.0 1.9 8.4 0.3 2.2 2 0 0 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) Thioredoxin PF00085.20 CDW61296.1 - 7.4e-09 35.5 0.0 7.9e-09 35.4 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 CDW61296.1 - 0.00064 19.7 0.0 0.0008 19.4 0.0 1.1 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE OST3_OST6 PF04756.13 CDW61296.1 - 0.0056 16.1 0.0 0.0056 16.1 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Phosducin PF02114.16 CDW61296.1 - 0.0089 15.0 0.0 0.01 14.8 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 CDW61297.1 - 1.3e-28 98.9 0.0 1.5e-28 98.8 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CDW61297.1 - 1.6e-06 28.5 0.0 3.4e-05 24.2 0.0 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 CDW61297.1 - 6.9e-05 22.8 0.0 9.5e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 CDW61297.1 - 0.00019 21.5 0.0 0.00033 20.8 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 CDW61297.1 - 0.0009 19.5 0.0 0.0046 17.3 0.0 1.9 1 1 1 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 CDW61297.1 - 0.0036 17.0 0.0 0.0042 16.8 0.0 1.3 1 1 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.6 CDW61297.1 - 0.039 13.7 0.0 0.053 13.3 0.0 1.3 1 1 0 1 1 1 0 Thioredoxin KaiB PF07689.12 CDW61297.1 - 0.063 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 KaiB domain Thioredoxin_4 PF13462.6 CDW61297.1 - 0.078 13.1 0.0 4 7.6 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin TraF PF13728.6 CDW61297.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Pyr_redox_2 PF07992.14 CDW61298.1 - 4.9e-47 160.6 5.0 5.6e-47 160.4 5.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CDW61298.1 - 3.5e-19 69.2 0.1 3.2e-13 49.6 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CDW61298.1 - 6.2e-14 52.3 1.7 2.6e-11 43.9 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CDW61298.1 - 1.4e-09 37.8 6.9 2.8e-07 30.3 0.7 2.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CDW61298.1 - 2.5e-07 30.8 1.2 2.8e-05 24.2 0.1 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CDW61298.1 - 3e-07 29.9 13.5 9.3e-07 28.3 0.8 4.2 3 1 1 5 5 5 1 FAD binding domain GIDA PF01134.22 CDW61298.1 - 3.4e-07 29.7 1.6 0.00052 19.2 0.3 3.2 3 0 0 3 3 3 2 Glucose inhibited division protein A DAO PF01266.24 CDW61298.1 - 8.5e-07 28.9 11.9 0.0088 15.7 0.9 4.1 3 1 1 4 4 4 3 FAD dependent oxidoreductase Thi4 PF01946.17 CDW61298.1 - 3.7e-06 26.3 1.2 9e-05 21.8 0.1 2.3 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 CDW61298.1 - 1.6e-05 24.3 6.6 0.00087 18.6 0.7 2.9 2 1 1 3 3 3 2 FAD binding domain NAD_binding_7 PF13241.6 CDW61298.1 - 0.00017 22.0 1.1 0.049 14.1 0.4 2.4 2 1 0 2 2 2 2 Putative NAD(P)-binding HI0933_like PF03486.14 CDW61298.1 - 0.0013 17.5 3.4 0.0088 14.8 0.4 2.8 3 0 0 3 3 3 1 HI0933-like protein FMO-like PF00743.19 CDW61298.1 - 0.0016 16.9 0.0 0.0023 16.4 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CDW61298.1 - 0.0021 17.3 0.2 0.16 11.1 0.1 2.8 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 CDW61298.1 - 0.092 11.6 6.1 0.67 8.7 0.6 2.7 3 0 0 3 3 3 0 Tryptophan halogenase DUF2190 PF09956.9 CDW61298.1 - 0.33 11.5 10.7 0.24 11.9 0.9 2.8 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2190) OB_NTP_bind PF07717.16 CDW61300.1 - 1.5e-26 92.5 0.0 2e-26 92.1 0.0 1.2 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DUF2621 PF11084.8 CDW61300.1 - 0.066 13.2 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) OapA PF04225.12 CDW61300.1 - 0.1 12.7 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Opacity-associated protein A LysM-like domain Pkinase PF00069.25 CDW61301.1 - 1.3e-22 80.4 0.0 1.5e-22 80.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CDW61301.1 - 2.4e-13 50.0 0.0 2.7e-13 49.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CDW61301.1 - 6.8e-05 22.0 0.1 7.3e-05 21.9 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 CDW61301.1 - 0.027 14.1 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 CDW61301.1 - 0.12 11.1 0.0 0.14 10.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CDW61301.1 - 0.15 12.0 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M18 PF02127.15 CDW61302.1 - 7.8e-26 90.8 0.0 8.6e-26 90.7 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) SH3_9 PF14604.6 CDW61303.1 - 9.4e-06 25.4 0.2 2.7e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 CDW61303.1 - 3.4e-05 23.4 0.1 6.8e-05 22.4 0.1 1.6 1 0 0 1 1 1 1 SH3 domain Bax1-I PF01027.20 CDW61306.1 - 1.5e-07 31.5 0.3 1.7e-07 31.3 0.3 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 TauE PF01925.19 CDW61306.1 - 0.0036 17.0 0.2 0.0042 16.8 0.2 1.1 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Neurensin PF14927.6 CDW61306.1 - 0.08 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Neurensin EGF_CA PF07645.15 CDW61307.1 - 2.7e-16 59.5 42.8 1.2e-09 38.2 10.4 4.0 4 0 0 4 4 4 3 Calcium-binding EGF domain EGF PF00008.27 CDW61307.1 - 1.6e-09 37.9 50.1 2.5e-06 27.7 8.9 4.2 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.7 CDW61307.1 - 1.1e-08 35.4 37.7 0.00047 20.7 6.2 5.2 4 1 0 4 4 4 3 Human growth factor-like EGF EGF_3 PF12947.7 CDW61307.1 - 4.5e-05 23.6 40.5 0.00027 21.1 10.9 3.7 3 0 0 3 3 3 3 EGF domain FXa_inhibition PF14670.6 CDW61307.1 - 0.0078 16.5 37.3 0.016 15.5 7.8 4.1 3 1 1 4 4 4 2 Coagulation Factor Xa inhibitory site cEGF PF12662.7 CDW61307.1 - 0.0093 15.9 4.0 0.0093 15.9 4.0 5.9 5 1 0 5 5 5 2 Complement Clr-like EGF-like EGF_2 PF07974.13 CDW61307.1 - 0.013 15.8 10.5 0.013 15.8 10.5 3.8 3 0 0 3 3 3 0 EGF-like domain Pkinase PF00069.25 CDW61308.1 - 7.5e-10 38.6 0.1 8.6e-10 38.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain MiAMP1 PF09117.10 CDW61308.1 - 0.048 13.9 0.1 0.079 13.2 0.1 1.3 1 0 0 1 1 1 0 MiAMP1 Piwi PF02171.17 CDW61309.1 - 4e-49 167.5 0.0 5e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Piwi domain Phe_ZIP PF08916.11 CDW61311.1 - 7.3e-16 58.6 8.1 1.4e-15 57.7 8.1 1.5 1 0 0 1 1 1 1 Phenylalanine zipper Tetraspanin PF00335.20 CDW61311.1 - 0.3 10.8 1.6 0.29 10.8 1.6 1.2 1 0 0 1 1 1 0 Tetraspanin family UPF0561 PF10573.9 CDW61313.1 - 0.12 12.5 2.9 0.13 12.4 0.6 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 Peptidase_C69 PF03577.15 CDW61315.1 - 1e-07 31.2 0.0 1.4e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C69 AA_permease PF00324.21 CDW61318.1 - 8.8e-28 97.1 22.1 7.6e-27 94.0 12.3 2.1 2 0 0 2 2 2 2 Amino acid permease Orf78 PF06024.12 CDW61318.1 - 0.14 12.5 0.6 4.4 7.7 0.2 2.7 2 0 0 2 2 2 0 Orf78 (ac78) Chromosome_seg PF13889.6 CDW61318.1 - 0.17 12.1 0.0 0.46 10.7 0.0 1.7 2 0 0 2 2 2 0 Chromosome segregation during meiosis dCMP_cyt_deam_1 PF00383.23 CDW61320.1 - 3.1e-12 46.3 0.0 5e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CDW61320.1 - 7.5e-10 38.7 0.5 3.3e-08 33.4 0.1 2.0 2 0 0 2 2 2 1 MafB19-like deaminase Bd3614-deam PF14439.6 CDW61320.1 - 0.003 17.6 0.3 0.0098 16.0 0.3 1.8 1 1 0 1 1 1 1 Bd3614-like deaminase APOBEC3 PF18771.1 CDW61320.1 - 0.18 11.9 0.1 1.1 9.3 0.1 2.0 2 0 0 2 2 2 0 APOBEC3 UPF0236 PF06782.11 CDW61321.1 - 9.6e-37 126.7 8.8 1.2e-36 126.4 8.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0236) Cu-oxidase_4 PF02578.15 CDW61321.1 - 0.11 12.1 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase YfcL PF08891.11 CDW61321.1 - 0.24 11.8 0.9 0.84 10.0 0.1 2.3 2 1 0 2 2 2 0 YfcL protein Cadherin PF00028.17 CDW61322.1 - 3.6e-19 69.0 0.0 7.3e-08 32.8 0.0 3.9 3 1 0 3 3 3 3 Cadherin domain Kelch_5 PF13854.6 CDW61323.1 - 0.00011 22.1 1.1 0.00032 20.6 0.0 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 CDW61323.1 - 0.0059 16.2 0.1 0.022 14.3 0.0 2.0 2 0 0 2 2 2 1 Kelch motif PSI PF01437.25 CDW61323.1 - 0.011 16.3 3.8 0.011 16.3 3.8 4.5 4 0 0 4 4 4 0 Plexin repeat Ole-e-6 PF09253.10 CDW61323.1 - 0.046 13.7 1.6 0.046 13.7 1.6 3.6 5 0 0 5 5 5 0 Pollen allergen ole e 6 Mito_carr PF00153.27 CDW61326.1 - 2.2e-15 56.3 0.1 1.2e-06 28.3 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF3291 PF11695.8 CDW61326.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3291) Pellino PF04710.14 CDW61327.1 - 6.5e-67 226.0 0.1 8.8e-66 222.3 0.1 2.0 1 1 0 1 1 1 1 Pellino zf-CCHC PF00098.23 CDW61328.1 - 9e-08 31.9 6.4 0.0014 18.6 1.0 2.4 2 0 0 2 2 2 2 Zinc knuckle DUF2321 PF10083.9 CDW61328.1 - 0.015 14.9 0.3 0.02 14.5 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-CCHC_4 PF14392.6 CDW61328.1 - 0.023 14.4 8.5 0.052 13.3 1.1 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-UBR PF02207.20 CDW61328.1 - 0.063 13.4 4.6 0.097 12.8 4.6 1.3 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-CCHC_3 PF13917.6 CDW61328.1 - 0.41 10.7 3.7 0.99 9.4 0.2 2.3 2 0 0 2 2 2 0 Zinc knuckle PolC_DP2 PF03833.13 CDW61328.1 - 1.4 6.7 2.5 1.2 6.9 1.8 1.3 1 1 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-CCHC_2 PF13696.6 CDW61328.1 - 2.4 8.1 7.3 1.7 8.5 1.2 2.4 2 0 0 2 2 2 0 Zinc knuckle Syntaxin PF00804.25 CDW61329.1 - 3.2e-28 98.8 2.4 5.5e-28 98.0 2.4 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 CDW61329.1 - 5.9e-17 61.4 0.0 1.1e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 SNARE domain MCPsignal PF00015.21 CDW61329.1 - 0.037 13.9 0.9 0.045 13.6 0.6 1.3 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Lzipper-MIP1 PF14389.6 CDW61329.1 - 0.051 13.9 0.2 0.099 13.0 0.1 1.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF3560 PF12083.8 CDW61329.1 - 0.057 13.5 0.1 0.4 10.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) FliS PF02561.14 CDW61329.1 - 0.062 13.6 1.3 0.14 12.5 0.4 1.9 1 1 1 2 2 2 0 Flagellar protein FliS Lge1 PF11488.8 CDW61329.1 - 0.14 12.4 0.3 0.14 12.4 0.3 1.7 2 1 1 3 3 3 0 Transcriptional regulatory protein LGE1 ABC_tran_Xtn PF12848.7 CDW61329.1 - 0.92 9.6 3.9 2.3 8.3 0.2 2.4 1 1 2 3 3 3 0 ABC transporter Glu_synthase PF01645.17 CDW61330.1 - 2.7e-30 105.7 0.1 3.6e-30 105.3 0.1 1.1 1 0 0 1 1 1 1 Conserved region in glutamate synthase Integrase_H2C2 PF17921.1 CDW61331.1 - 7.7e-05 22.7 1.8 0.00022 21.2 1.8 1.7 1 1 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 CDW61331.1 - 1.2 9.5 4.1 3.8 7.8 3.0 2.4 1 1 0 1 1 1 0 H2C2 zinc finger Motile_Sperm PF00635.26 CDW61333.1 - 1.1e-12 47.8 0.1 3.7e-12 46.1 0.0 1.9 1 1 1 2 2 2 1 MSP (Major sperm protein) domain Piwi PF02171.17 CDW61334.1 - 4.2e-73 246.2 0.2 1.8e-64 217.9 0.0 2.2 1 1 1 2 2 2 2 Piwi domain AID PF18767.1 CDW61335.1 - 0.08 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Activation induced deaminase TPR_1 PF00515.28 CDW61336.1 - 0.00011 21.9 3.4 0.002 17.9 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CDW61336.1 - 0.00039 20.4 1.4 0.042 14.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 CDW61336.1 - 0.0011 18.6 0.0 0.0025 17.5 0.0 1.6 1 0 0 1 1 1 1 TPR repeat TPR_2 PF07719.17 CDW61336.1 - 0.032 14.3 4.3 0.28 11.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_S28e PF01200.18 CDW61338.1 - 2.4e-21 75.5 0.2 2.8e-21 75.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e DC_STAMP PF07782.13 CDW61339.1 - 0.00031 20.6 3.1 0.0005 20.0 3.1 1.4 1 0 0 1 1 1 1 DC-STAMP-like protein PolC_DP2 PF03833.13 CDW61339.1 - 0.002 16.1 1.4 0.0022 15.9 1.4 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 SR-25 PF10500.9 CDW61339.1 - 0.0045 16.6 9.0 0.0074 15.9 7.9 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein CEBP_ZZ PF16366.5 CDW61339.1 - 0.84 9.9 11.4 1.5 9.1 11.4 1.4 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain GcnA_N PF18229.1 CDW61340.1 - 0.17 12.0 0.3 1.7 8.8 0.1 2.5 2 0 0 2 2 2 0 N-acetyl-beta-D-glucosaminidase N-terminal domain CCDC53 PF10152.9 CDW61340.1 - 0.27 11.6 8.1 4 7.8 1.2 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Herpes_DNAp_acc PF04929.12 CDW61340.1 - 0.89 8.5 6.1 1.2 8.0 0.3 2.1 2 0 0 2 2 2 0 Herpes DNA replication accessory factor HHH_3 PF12836.7 CDW61341.1 - 9.4e-19 67.4 0.0 1.2e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_9 PF17674.1 CDW61341.1 - 1.1e-06 29.4 0.2 2.4e-06 28.3 0.2 1.6 1 0 0 1 1 1 1 HHH domain HHH_7 PF14635.6 CDW61341.1 - 1.2e-06 28.8 0.0 1.6e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix motif Glycogen_syn PF05693.13 CDW61342.1 - 2.8e-57 194.7 0.0 3.3e-57 194.4 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase RVP_2 PF08284.11 CDW61342.1 - 0.11 12.2 0.0 0.52 10.1 0.0 2.0 2 0 0 2 2 2 0 Retroviral aspartyl protease NurA PF09376.10 CDW61343.1 - 0.063 13.0 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 NurA domain Rbx_binding PF18113.1 CDW61345.1 - 0.12 12.1 0.0 0.15 11.9 0.0 1.1 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain Asp_protease_2 PF13650.6 CDW61346.1 - 1.4e-07 32.1 0.0 1.9e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CDW61346.1 - 4.2e-07 30.4 0.0 5.8e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease RVP PF00077.20 CDW61346.1 - 6.1e-05 23.3 0.0 0.0001 22.6 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 CDW61346.1 - 0.0025 17.6 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2E PF12382.8 CDW61346.1 - 0.16 12.0 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon peptidase PhoLip_ATPase_N PF16209.5 CDW61348.1 - 8.4e-23 79.8 2.6 1.2e-22 79.3 2.6 1.2 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal DUF2238 PF09997.9 CDW61348.1 - 0.031 14.1 0.1 0.033 14.0 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2238) Glyco_hydro_18 PF00704.28 CDW61351.1 - 2.6e-16 60.3 0.1 8.9e-08 32.2 0.0 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 18 Peptidase_M13_N PF05649.13 CDW61354.1 - 3.4e-10 40.2 0.1 4.4e-10 39.8 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M13 SNF PF00209.18 CDW61355.1 - 3.4e-18 65.6 0.6 4.2e-18 65.4 0.6 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family RT_RNaseH_2 PF17919.1 CDW61356.1 - 8.1e-29 99.6 0.1 1.3e-28 99.0 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 CDW61356.1 - 1.2e-25 89.8 0.0 1.9e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 CDW61356.1 - 0.045 13.9 0.0 0.093 12.8 0.0 1.5 1 0 0 1 1 1 0 Integrase zinc binding domain Gemini_coat PF00844.18 CDW61357.1 - 0.2 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Geminivirus coat protein/nuclear export factor BR1 family Cep57_MT_bd PF06657.13 CDW61358.1 - 0.13 12.7 12.2 3.9 8.0 0.3 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF229 PF02995.17 CDW61360.1 - 1.2e-89 301.2 0.1 3.8e-54 184.1 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF229) Phosphodiest PF01663.22 CDW61360.1 - 0.068 12.7 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase IQ_SEC7_PH PF16453.5 CDW61361.1 - 6e-09 36.0 0.1 8.4e-09 35.5 0.1 1.2 1 0 0 1 1 1 1 PH domain PH PF00169.29 CDW61361.1 - 1.1e-06 29.1 0.3 1.4e-06 28.7 0.3 1.1 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 CDW61361.1 - 1.4e-05 25.0 1.6 0.00057 19.7 1.6 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_10 PF15411.6 CDW61361.1 - 0.011 16.0 0.1 0.013 15.7 0.1 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 CDW61361.1 - 0.1 12.4 2.0 1.3 8.9 2.0 2.1 1 1 0 1 1 1 0 PH domain rve PF00665.26 CDW61363.1 - 7.1e-19 68.2 0.0 2.9e-18 66.2 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain HTH_21 PF13276.6 CDW61363.1 - 2.5e-11 43.5 3.9 1.3e-10 41.2 0.6 2.9 3 0 0 3 3 3 1 HTH-like domain rve_3 PF13683.6 CDW61363.1 - 8.7e-11 41.4 1.2 1.1e-10 41.1 0.1 1.8 2 0 0 2 2 2 1 Integrase core domain rve_2 PF13333.6 CDW61363.1 - 1.4e-10 41.2 0.3 3e-10 40.1 0.3 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 CDW61363.1 - 0.00047 20.4 0.0 0.001 19.3 0.0 1.5 1 0 0 1 1 1 1 DDE domain HTH_17 PF12728.7 CDW61363.1 - 0.0016 18.5 0.0 0.037 14.2 0.0 2.7 2 0 0 2 2 2 1 Helix-turn-helix domain MerR PF00376.23 CDW61363.1 - 0.03 14.1 0.2 7.8 6.4 0.1 2.4 2 0 0 2 2 2 0 MerR family regulatory protein HTH_Tnp_1_2 PF13022.6 CDW61363.1 - 0.042 14.0 0.0 0.1 12.8 0.0 1.8 1 1 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_33 PF13592.6 CDW61363.1 - 0.055 13.1 0.2 5.8 6.6 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn helix HTH_Tnp_1 PF01527.20 CDW61363.1 - 0.11 12.8 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 Transposase HTH_3 PF01381.22 CDW61363.1 - 0.17 12.0 0.1 0.58 10.3 0.1 1.9 1 0 0 1 1 1 0 Helix-turn-helix PAZ PF02170.22 CDW61365.1 - 2.8e-15 56.3 0.0 4.8e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 CDW61365.1 - 2.9e-11 43.5 0.0 6.6e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoL1 PF08699.10 CDW61365.1 - 8.7e-11 41.3 0.0 2e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 CDW61365.1 - 2.1e-10 41.4 0.0 3.5e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoMid PF16487.5 CDW61365.1 - 0.011 15.9 0.2 0.041 14.2 0.1 2.0 2 0 0 2 2 2 0 Mid domain of argonaute SAP18 PF06487.12 CDW61366.1 - 3e-38 131.1 0.0 3.9e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) TM2 PF05154.16 CDW61369.1 - 4.2e-06 27.0 1.4 6.2e-06 26.5 1.4 1.2 1 0 0 1 1 1 1 TM2 domain Integrase_H2C2 PF17921.1 CDW61370.1 - 8e-12 45.1 0.0 1.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain Retrotran_gag_2 PF14223.6 CDW61373.1 - 6.6e-42 142.5 0.0 1.7e-32 112.0 0.0 2.1 2 0 0 2 2 2 2 gag-polypeptide of LTR copia-type zf-CCHC PF00098.23 CDW61373.1 - 2.4e-05 24.2 3.8 9.7e-05 22.3 3.8 2.1 1 0 0 1 1 1 1 Zinc knuckle DUF2464 PF10240.9 CDW61373.1 - 0.0014 18.2 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 2 Multivesicular body subunit 12 MgtE_N PF03448.17 CDW61373.1 - 0.0016 19.0 0.0 2.8 8.6 0.0 2.3 2 0 0 2 2 2 2 MgtE intracellular N domain Na_Ca_ex PF01699.24 CDW61373.1 - 0.016 15.2 0.0 6.5 6.7 0.0 2.2 2 0 0 2 2 2 0 Sodium/calcium exchanger protein Cas_Csd1 PF09709.10 CDW61373.1 - 0.016 13.9 1.3 0.072 11.8 0.3 2.2 2 1 0 2 2 2 0 CRISPR-associated protein (Cas_Csd1) GvpL_GvpF PF06386.11 CDW61373.1 - 0.028 14.3 0.2 1.2 9.1 0.1 2.2 1 1 1 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF SoxE PF06525.11 CDW61373.1 - 0.11 12.0 0.0 2.6 7.5 0.0 2.3 1 1 1 2 2 2 0 Sulfocyanin (SoxE) domain zf-CCHC_4 PF14392.6 CDW61373.1 - 0.15 11.8 1.0 0.45 10.3 1.0 1.9 1 0 0 1 1 1 0 Zinc knuckle DUF148 PF02520.17 CDW61373.1 - 0.21 11.7 0.1 1.2 9.3 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function DUF148 APAF1_C PF17908.1 CDW61374.1 - 1.1e-14 54.6 1.1 2.8e-14 53.2 0.2 1.9 2 0 0 2 2 2 1 APAF-1 helical domain DUF5641 PF18701.1 CDW61376.1 - 1.2e-31 108.7 3.1 1.5e-31 108.4 3.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Retrotrans_gag PF03732.17 CDW61378.1 - 0.0013 19.0 0.0 0.003 17.8 0.0 1.6 2 0 0 2 2 2 1 Retrotransposon gag protein SCAN PF02023.17 CDW61378.1 - 0.04 13.7 0.4 0.93 9.3 0.4 2.6 1 1 0 1 1 1 0 SCAN domain Zn_Tnp_IS1595 PF12760.7 CDW61380.1 - 0.0082 16.1 0.5 0.023 14.7 0.5 1.8 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 CDW61380.1 - 0.05 14.0 8.5 0.18 12.3 0.9 2.7 3 0 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.12 CDW61380.1 - 0.18 12.1 0.5 0.18 12.1 0.5 1.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CDW61380.1 - 0.75 10.8 10.6 1.1 10.3 0.3 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger HTH_28 PF13518.6 CDW61382.1 - 1.8e-30 104.8 14.5 1.8e-13 50.4 0.1 5.2 5 0 0 5 5 5 4 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 CDW61382.1 - 7.5e-26 90.3 8.0 2.6e-09 37.2 0.6 4.3 3 1 1 4 4 4 3 Transposase HTH_23 PF13384.6 CDW61382.1 - 3.5e-18 64.8 6.7 1.2e-08 34.5 0.0 4.6 4 0 0 4 4 4 3 Homeodomain-like domain HTH_29 PF13551.6 CDW61382.1 - 1.1e-17 63.8 3.5 3.2e-07 30.3 0.0 4.5 4 0 0 4 4 4 3 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.6 CDW61382.1 - 2e-07 30.3 0.0 0.011 15.1 0.0 3.4 3 0 0 3 3 3 2 Helix-turn-helix domain of transposase family ISL3 HTH_32 PF13565.6 CDW61382.1 - 3.6e-07 30.7 10.9 9.9e-05 22.9 1.1 4.3 4 1 1 5 5 4 2 Homeodomain-like domain LZ_Tnp_IS481 PF13011.6 CDW61382.1 - 0.00035 21.0 5.2 0.043 14.4 0.2 3.3 3 0 0 3 3 3 1 leucine-zipper of insertion element IS481 BrkDBD PF09607.10 CDW61382.1 - 0.0027 17.4 6.2 0.67 9.8 0.6 3.6 3 0 0 3 3 3 2 Brinker DNA-binding domain DUF4817 PF16087.5 CDW61382.1 - 0.0052 16.6 0.8 5.2 7.0 0.1 4.1 3 1 0 3 3 3 1 Helix-turn-helix domain (DUF4817) HTH_7 PF02796.15 CDW61382.1 - 0.0068 16.4 0.2 32 4.7 0.0 4.3 4 0 0 4 4 4 0 Helix-turn-helix domain of resolvase HTH_3 PF01381.22 CDW61382.1 - 0.0076 16.3 0.3 0.86 9.7 0.0 3.2 3 0 0 3 3 3 1 Helix-turn-helix HTH_21 PF13276.6 CDW61382.1 - 0.011 15.9 0.2 0.032 14.4 0.2 1.9 1 0 0 1 1 1 0 HTH-like domain Sigma70_r4_2 PF08281.12 CDW61382.1 - 0.011 15.4 2.2 3.2 7.5 0.0 3.4 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_Tnp_1_2 PF13022.6 CDW61382.1 - 0.011 15.8 2.7 0.36 11.0 0.1 3.4 2 1 2 4 4 4 0 Helix-turn-helix of insertion element transposase PcfK PF14058.6 CDW61382.1 - 0.014 15.7 0.4 0.032 14.5 0.4 1.6 1 0 0 1 1 1 0 PcfK-like protein HTH_19 PF12844.7 CDW61382.1 - 0.014 15.4 0.0 1 9.4 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_30 PF13556.6 CDW61382.1 - 0.036 13.9 0.4 11 6.0 0.0 3.0 3 0 0 3 3 3 0 PucR C-terminal helix-turn-helix domain Trp_repressor PF01371.19 CDW61382.1 - 0.093 12.9 0.0 16 5.7 0.0 2.8 2 0 0 2 2 2 0 Trp repressor protein DUF1804 PF08822.11 CDW61382.1 - 0.11 12.5 2.6 5.1 7.0 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1804) HTH_Tnp_4 PF13613.6 CDW61382.1 - 0.12 12.1 2.2 0.24 11.2 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix of DDE superfamily endonuclease Sacchrp_dh_NADP PF03435.18 CDW61382.1 - 0.14 12.5 0.1 0.4 10.9 0.1 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain CEP209_CC5 PF16574.5 CDW61382.1 - 0.45 10.7 8.4 0.067 13.3 3.6 2.1 2 1 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 Pribosyltran_N PF13793.6 CDW61383.1 - 1.2e-14 54.3 0.1 1.3e-14 54.1 0.1 1.0 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase TPR_8 PF13181.6 CDW61384.1 - 0.00049 20.1 0.2 0.032 14.4 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CDW61384.1 - 0.0033 17.4 0.0 0.0098 15.9 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CDW61384.1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 CDW61384.1 - 0.035 14.7 0.3 5 8.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CDW61384.1 - 0.053 13.4 0.4 0.44 10.5 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat WAPL PF07814.13 CDW61385.1 - 3e-07 29.5 0.0 3.8e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin gag-asp_proteas PF13975.6 CDW61386.1 - 7.6e-06 26.4 0.4 2e-05 25.1 0.1 1.8 1 1 1 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CDW61386.1 - 0.00038 21.0 0.0 0.00061 20.4 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease RVP PF00077.20 CDW61386.1 - 0.0046 17.2 0.0 0.0063 16.8 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease Asp_protease PF09668.10 CDW61386.1 - 0.02 14.7 0.1 0.052 13.3 0.1 1.7 1 1 0 1 1 1 0 Aspartyl protease RVP_2 PF08284.11 CDW61386.1 - 0.024 14.4 0.3 0.036 13.8 0.3 1.4 1 1 0 1 1 1 0 Retroviral aspartyl protease NAC PF01849.18 CDW61387.1 - 0.057 13.4 0.0 0.092 12.7 0.0 1.3 1 0 0 1 1 1 0 NAC domain SCAN PF02023.17 CDW61389.1 - 0.066 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 SCAN domain DUF1759 PF03564.15 CDW61389.1 - 0.14 12.1 0.2 0.41 10.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Trichuris_trichiura-TTRE2.1/GCA_000613005.1_TTRE2.1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Trichuris_trichiura-TTRE2.1/GCA_000613005.1_TTRE2.1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Trichuris_trichiura-TTRE2.1/GCA_000613005.1_TTRE2.1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Trichuris_trichiura-TTRE2.1/GCA_000613005.1_TTRE2.1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 19:22:47 2019 # [ok]