# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Ribosomal_S21 PF01165.20 VDK67029.1 - 4.4e-09 35.9 0.1 8.6e-09 35.0 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein S21 Proteasome PF00227.26 VDK67031.1 - 5.7e-41 140.1 0.0 6.8e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Peptidase_C48 PF02902.19 VDK67032.1 - 3.2e-36 125.2 0.1 5.2e-36 124.5 0.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Adaptin_N PF01602.20 VDK67034.1 - 1.1e-107 360.8 10.7 1.7e-107 360.2 10.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 VDK67034.1 - 2.7e-55 185.8 0.0 1.1e-54 183.9 0.0 2.1 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 VDK67034.1 - 2.1e-53 180.0 0.2 4.9e-53 178.8 0.2 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Cnd1 PF12717.7 VDK67034.1 - 3.9e-09 36.8 9.2 1.2e-06 28.7 0.1 3.6 2 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 VDK67034.1 - 3e-08 33.9 2.4 0.0029 17.9 0.0 4.7 3 2 2 5 5 5 2 HEAT repeats HEAT PF02985.22 VDK67034.1 - 4.2e-07 29.7 1.2 0.21 11.9 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 VDK67034.1 - 0.00037 20.9 3.2 1 9.9 0.0 4.0 5 0 0 5 5 5 2 HEAT-like repeat Arm PF00514.23 VDK67034.1 - 0.0037 17.3 0.1 13 6.0 0.0 3.8 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat DUF5578 PF17741.1 VDK67034.1 - 0.36 10.2 4.6 1.8 8.0 0.2 3.1 1 1 2 3 3 3 0 Family of unknown function (DUF5578) Cadherin PF00028.17 VDK67035.1 - 4.8e-11 43.0 0.0 7.2e-10 39.2 0.0 2.6 2 0 0 2 2 2 1 Cadherin domain Transmemb_17 PF09799.9 VDK67037.1 - 7.6e-19 68.3 16.1 7.6e-19 68.3 16.1 2.0 2 0 0 2 2 2 1 Predicted membrane protein EMG1 PF03587.14 VDK67038.1 - 2.7e-58 196.9 0.1 3.7e-58 196.4 0.1 1.2 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Peptidase_C14 PF00656.22 VDK67041.1 - 3.5e-46 158.2 0.0 4.8e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Caspase domain CARD PF00619.21 VDK67041.1 - 2.6e-10 40.2 0.4 8.1e-10 38.6 0.2 2.0 2 0 0 2 2 2 1 Caspase recruitment domain Ribosomal_L17 PF01196.19 VDK67044.1 - 3.8e-06 27.7 0.0 5.6e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Ras PF00071.22 VDK67048.1 - 4e-53 179.3 0.0 4.9e-53 179.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK67048.1 - 5.5e-19 68.5 0.0 8.4e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK67048.1 - 1.7e-08 34.1 0.0 2.5e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ig PF00047.25 VDK67048.1 - 0.00075 19.6 0.0 0.0013 18.8 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 VDK67048.1 - 0.0013 18.7 0.0 0.0024 17.9 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain GTP_EFTU PF00009.27 VDK67048.1 - 0.0081 15.7 0.0 0.029 13.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PET117 PF15786.5 VDK67048.1 - 0.021 15.1 0.0 0.04 14.2 0.0 1.4 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial Ig_6 PF18452.1 VDK67048.1 - 0.027 14.0 0.0 0.14 11.8 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain Ig_3 PF13927.6 VDK67048.1 - 0.056 14.1 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 VDK67048.1 - 0.16 12.2 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin V-set domain DUF1394 PF07159.12 VDK67049.1 - 2.5e-110 368.5 0.1 2.9e-110 368.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) F-box-like PF12937.7 VDK67049.1 - 0.11 12.4 0.4 1.9 8.4 0.1 2.8 3 0 0 3 3 3 0 F-box-like SMC_N PF02463.19 VDK67050.1 - 1.6e-10 40.8 0.0 2.3e-10 40.3 0.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 VDK67050.1 - 0.0001 22.2 1.8 0.00057 19.8 0.8 2.6 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Laminin_II PF06009.12 VDK67050.1 - 1.6 8.7 46.4 0.022 14.8 5.6 5.6 5 1 1 6 6 6 0 Laminin Domain II ELM2 PF01448.24 VDK67052.1 - 1.5e-06 28.8 1.3 3.4e-06 27.7 0.0 2.2 2 1 0 2 2 2 1 ELM2 domain zf-RING_7 PF02591.15 VDK67052.1 - 0.18 12.0 0.3 0.5 10.6 0.3 1.7 1 0 0 1 1 1 0 C4-type zinc ribbon domain DNA_pol_phi PF04931.13 VDK67052.1 - 5.2 5.0 15.1 7.5 4.5 15.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF3328 PF11807.8 VDK67053.1 - 0.029 14.1 0.0 0.036 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF3135 PF11333.8 VDK67053.1 - 0.12 12.6 0.1 0.21 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) RelE PF06296.12 VDK67054.1 - 0.019 15.0 0.0 0.022 14.9 0.0 1.2 1 0 0 1 1 1 0 RelE toxin of RelE / RelB toxin-antitoxin system RSN1_7TM PF02714.15 VDK67054.1 - 0.03 13.6 0.0 0.035 13.4 0.0 1.0 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate Yop-YscD_cpl PF16697.5 VDK67055.1 - 4.6e-06 26.9 0.0 1.6e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Alpha-amylase PF00128.24 VDK67056.1 - 9.2e-45 153.7 2.1 1.4e-44 153.0 2.1 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Ribosomal_L44 PF00935.19 VDK67056.1 - 4.1e-33 113.7 14.1 9.4e-33 112.5 14.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L44 SLC3A2_N PF16028.5 VDK67056.1 - 2.2e-15 55.9 3.4 5.8e-15 54.6 3.4 1.7 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus E1-E2_ATPase PF00122.20 VDK67115.1 - 0.032 13.8 8.5 0.023 14.2 6.8 1.6 1 1 0 1 1 1 0 E1-E2 ATPase AcrZ PF10766.9 VDK67115.1 - 0.1 12.2 1.8 0.38 10.3 1.8 2.0 1 0 0 1 1 1 0 Multidrug efflux pump-associated protein AcrZ WD40 PF00400.32 VDK67116.1 - 1e-26 92.6 14.3 7.2e-06 26.6 0.0 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK67116.1 - 1.4e-17 63.8 4.9 1.3e-07 31.8 0.4 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK67116.1 - 6.8e-06 26.1 0.0 0.18 11.7 0.0 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 VDK67116.1 - 0.014 14.1 0.1 0.024 13.3 0.1 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 WD40_like PF17005.5 VDK67116.1 - 0.062 12.6 0.0 11 5.2 0.0 2.4 3 0 0 3 3 3 0 WD40-like domain Ge1_WD40 PF16529.5 VDK67116.1 - 0.066 12.2 0.1 0.89 8.5 0.0 2.6 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DNA_pol_A_exo1 PF01612.20 VDK67117.1 - 1.5e-27 96.4 0.5 1.4e-26 93.3 0.1 2.6 2 1 0 2 2 2 1 3'-5' exonuclease Mut7-C PF01927.16 VDK67117.1 - 2.4e-16 60.2 7.5 1.2e-10 41.7 0.1 3.8 4 0 0 4 4 4 3 Mut7-C RNAse domain DUF325 PF03804.13 VDK67117.1 - 0.56 10.3 3.3 15 5.7 0.2 3.3 3 0 0 3 3 3 0 Viral proteins of unknown function SmAKAP PF15127.6 VDK67121.1 - 0.25 12.6 3.6 0.63 11.3 3.6 2.0 1 1 0 1 1 1 0 Small membrane A-kinase anchor protein RNase_PH PF01138.21 VDK67122.1 - 2.8e-17 63.5 0.2 5.9e-17 62.4 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 VDK67122.1 - 0.028 14.4 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 UQ_con PF00179.26 VDK67124.1 - 1.9e-20 73.0 0.0 2.9e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK67124.1 - 0.011 15.4 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Galactosyl_T PF01762.21 VDK67127.1 - 2.5e-25 89.5 0.0 3.5e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase GWT1 PF06423.12 VDK67129.1 - 1.9e-22 80.0 7.0 1.9e-22 80.0 7.0 3.6 3 1 0 3 3 3 2 GWT1 GWT1 PF06423.12 VDK67130.1 - 7.4e-18 65.1 0.2 7.4e-18 65.1 0.2 2.7 2 1 0 2 2 2 1 GWT1 DUF373 PF04123.13 VDK67130.1 - 0.0021 17.6 0.7 0.0021 17.6 0.7 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF373) DUF3487 PF11990.8 VDK67130.1 - 2 8.4 6.2 2.5 8.0 3.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3487) AAA PF00004.29 VDK67131.1 - 5.1e-40 136.9 0.0 1.2e-39 135.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK67131.1 - 9.7e-09 34.9 0.1 2.3e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 VDK67131.1 - 7.1e-05 23.1 0.1 0.0068 16.7 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 VDK67131.1 - 0.00034 21.0 0.1 0.0041 17.5 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 VDK67131.1 - 0.00038 20.5 0.0 0.0016 18.4 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 VDK67131.1 - 0.0033 16.6 0.0 0.0065 15.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 VDK67131.1 - 0.0036 17.1 0.0 0.011 15.5 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 VDK67131.1 - 0.0059 16.0 0.0 1.2 8.5 0.0 2.4 2 0 0 2 2 2 1 KaiC AAA_2 PF07724.14 VDK67131.1 - 0.01 16.0 0.0 0.035 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 VDK67131.1 - 0.015 15.5 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 VDK67131.1 - 0.015 15.5 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 VDK67131.1 - 0.016 14.9 0.1 0.12 12.1 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 VDK67131.1 - 0.019 14.5 0.0 0.04 13.4 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 VDK67131.1 - 0.022 15.3 0.0 0.065 13.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 VDK67131.1 - 0.04 14.3 0.0 0.093 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 VDK67131.1 - 0.06 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 VDK67131.1 - 0.073 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 VDK67131.1 - 0.082 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 VDK67131.1 - 0.091 12.6 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 VDK67131.1 - 0.095 12.4 0.1 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_14 PF13173.6 VDK67131.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 VDK67131.1 - 0.13 12.0 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Prot_ATP_ID_OB PF16450.5 VDK67131.1 - 0.14 12.1 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Ras PF00071.22 VDK67132.1 - 4.9e-62 208.3 1.3 6.9e-62 207.8 1.3 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK67132.1 - 8.3e-34 116.4 0.6 1.4e-33 115.7 0.6 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK67132.1 - 1.6e-13 50.5 0.2 2.2e-13 50.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 VDK67132.1 - 0.00016 21.1 0.1 0.00065 19.2 0.0 1.7 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 VDK67132.1 - 0.00018 21.6 0.1 0.00041 20.4 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 VDK67132.1 - 0.00037 20.1 0.1 0.0011 18.5 0.1 1.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 VDK67132.1 - 0.0013 18.3 0.0 0.77 9.3 0.0 2.2 2 0 0 2 2 2 2 Ferrous iron transport protein B Gtr1_RagA PF04670.12 VDK67132.1 - 0.0016 17.9 0.1 0.0022 17.4 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 VDK67132.1 - 0.0031 17.4 0.3 0.2 11.5 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase DUF2757 PF10955.8 VDK67132.1 - 0.068 13.4 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) G-alpha PF00503.20 VDK67132.1 - 0.25 10.5 2.0 21 4.1 0.4 2.9 1 1 1 2 2 2 0 G-protein alpha subunit GCFC PF07842.12 VDK67133.1 - 4.7e-83 279.0 13.6 6.8e-83 278.5 13.6 1.2 1 0 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein TIP_N PF12457.8 VDK67133.1 - 1.9e-18 66.7 3.0 1.9e-18 66.7 3.0 1.8 2 0 0 2 2 2 1 Tuftelin interacting protein N terminal G-patch PF01585.23 VDK67133.1 - 4.2e-16 58.5 0.6 8.3e-16 57.6 0.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 VDK67133.1 - 9.4e-05 22.4 0.4 0.00033 20.7 0.4 2.0 1 0 0 1 1 1 1 G-patch domain Peptidase_U32_C PF16325.5 VDK67133.1 - 0.063 13.6 0.0 0.48 10.7 0.0 2.4 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain Zot PF05707.12 VDK67133.1 - 0.074 12.7 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) FlxA PF14282.6 VDK67133.1 - 0.11 12.5 0.2 0.26 11.3 0.2 1.6 1 0 0 1 1 1 0 FlxA-like protein FUSC PF04632.12 VDK67133.1 - 0.78 8.2 2.0 1.4 7.4 2.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family FRG2 PF15315.6 VDK67133.1 - 1.4 9.1 3.5 0.72 10.0 0.6 1.9 2 0 0 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 Uso1_p115_C PF04871.13 VDK67133.1 - 5.2 7.4 10.7 0.075 13.4 2.2 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Hexapep PF00132.24 VDK67134.1 - 0.00049 19.7 1.8 0.0011 18.6 1.7 1.7 1 1 0 1 1 1 1 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 VDK67134.1 - 0.027 12.6 0.2 0.029 12.5 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 VDK67134.1 - 0.066 13.0 5.0 1.4 8.8 5.0 2.1 1 1 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase HisKA_2 PF07568.12 VDK67134.1 - 0.093 12.8 0.0 0.1 12.7 0.0 1.0 1 0 0 1 1 1 0 Histidine kinase NTP_transferase PF00483.23 VDK67135.1 - 1.2e-12 47.9 0.0 2.1e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 VDK67135.1 - 7.1e-07 29.7 0.0 1e-06 29.2 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Steroid_dh PF02544.16 VDK67136.1 - 3.1e-36 124.6 4.3 3.1e-36 124.6 4.3 1.8 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Ribosomal_L7Ae PF01248.26 VDK67137.1 - 5.1e-27 93.5 0.1 6.6e-27 93.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 VDK67137.1 - 0.00023 21.3 0.1 0.00026 21.1 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 VDK67137.1 - 0.0005 19.9 0.0 0.00071 19.4 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain FlaC_arch PF05377.11 VDK67137.1 - 0.05 14.0 0.3 0.1 13.0 0.3 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) TRAP-gamma PF07074.12 VDK67138.1 - 6.4e-78 260.2 5.4 9.2e-78 259.6 5.4 1.2 1 0 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) HLH PF00010.26 VDK67138.1 - 9.7e-07 28.7 0.3 3.4e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain TUDOR PF00567.24 VDK67139.1 - 0.0047 17.0 0.0 0.0077 16.3 0.0 1.3 1 0 0 1 1 1 1 Tudor domain TUDOR PF00567.24 VDK67140.1 - 0.00076 19.5 0.0 0.0035 17.4 0.0 2.0 1 1 0 1 1 1 1 Tudor domain Phospholip_A2_1 PF00068.19 VDK67141.1 - 2.7e-09 37.5 10.4 2.7e-09 37.5 10.4 1.5 1 1 0 1 1 1 1 Phospholipase A2 EB PF01683.18 VDK67141.1 - 0.0021 18.3 4.6 0.0021 18.3 4.6 1.8 1 1 1 2 2 2 1 EB module Ly-6_related PF06579.12 VDK67142.1 - 5.4e-33 113.9 3.0 2.9e-16 59.9 1.0 2.1 1 1 1 2 2 2 2 Caenorhabditis elegans ly-6-related protein ecTbetaR2 PF08917.10 VDK67142.1 - 0.05 13.5 0.6 0.31 11.0 0.3 2.1 1 1 0 2 2 2 0 Transforming growth factor beta receptor 2 ectodomain QVR PF17064.5 VDK67142.1 - 0.72 10.1 4.1 18 5.7 4.1 2.6 1 1 0 1 1 1 0 Sleepless protein His_Phos_1 PF00300.22 VDK67143.1 - 3.3e-15 56.3 0.0 8.6e-13 48.4 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) TFIIA PF03153.13 VDK67144.1 - 6.3 6.7 12.3 7 6.5 12.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-C2H2 PF00096.26 VDK67145.1 - 9.1e-21 73.1 40.8 2.1e-06 27.8 2.4 6.1 5 1 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK67145.1 - 3e-15 55.9 50.0 1e-07 32.0 1.8 6.5 7 1 0 7 7 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK67145.1 - 2.2e-13 49.8 38.2 0.00062 20.4 1.1 5.8 5 1 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 VDK67145.1 - 0.0011 18.8 1.1 0.0011 18.8 1.1 5.6 5 0 0 5 5 5 2 C2H2-type zinc finger zf-TRAF PF02176.18 VDK67145.1 - 0.0017 19.0 3.0 0.0017 19.0 3.0 2.9 3 0 0 3 3 2 1 TRAF-type zinc finger NMD3 PF04981.13 VDK67145.1 - 0.0021 17.6 0.1 0.0021 17.6 0.1 1.9 2 1 0 2 2 2 1 NMD3 family zf-C2HC_2 PF13913.6 VDK67145.1 - 0.0051 16.7 17.0 0.27 11.2 0.0 4.8 5 0 0 5 5 4 2 zinc-finger of a C2HC-type zf-Di19 PF05605.12 VDK67145.1 - 0.0055 17.0 22.8 0.11 12.7 6.0 4.4 3 2 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-CHCC PF10276.9 VDK67145.1 - 0.016 15.2 7.3 1.2 9.3 0.3 3.2 3 0 0 3 3 3 0 Zinc-finger domain zf-BED PF02892.15 VDK67145.1 - 0.031 14.3 22.1 0.43 10.6 1.9 4.1 3 1 1 4 4 4 0 BED zinc finger zf-C2H2_jaz PF12171.8 VDK67145.1 - 0.11 12.9 23.5 0.41 11.0 0.7 5.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDK67145.1 - 0.12 12.8 26.3 0.67 10.3 5.1 4.4 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.9 VDK67145.1 - 0.16 12.1 3.6 5.5 7.2 0.0 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_9 PF16293.5 VDK67145.1 - 0.19 11.6 0.1 0.19 11.6 0.1 4.0 5 0 0 5 5 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_11 PF16622.5 VDK67145.1 - 1.5 8.6 24.2 0.63 9.8 1.8 4.5 5 0 0 5 5 5 0 zinc-finger C2H2-type DUF3268 PF11672.8 VDK67145.1 - 1.9 8.9 7.7 7.4 6.9 1.6 3.3 2 1 1 3 3 3 0 zinc-finger-containing domain PyrI_C PF02748.15 VDK67145.1 - 3.2 7.7 14.0 8.9 6.3 0.1 4.3 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Cys_rich_CPXG PF14255.6 VDK67145.1 - 5.8 6.9 6.4 8.7 6.3 0.2 3.2 3 0 0 3 3 3 0 Cysteine-rich CPXCG XPA_N PF01286.18 VDK67145.1 - 8.6 6.5 8.1 6.4 6.9 0.2 3.5 4 0 0 4 4 3 0 XPA protein N-terminal Rhodanese_C PF12368.8 VDK67145.1 - 9 6.8 10.9 16 5.9 0.5 3.7 1 1 3 4 4 4 0 Rhodanase C-terminal zf-CCHC PF00098.23 VDK67146.1 - 5.6e-12 45.2 25.8 7.3e-05 22.7 0.5 4.3 4 0 0 4 4 4 4 Zinc knuckle DUF2680 PF10925.8 VDK67146.1 - 0.0029 17.5 0.2 0.0093 15.9 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2680) zf-CCHC_5 PF14787.6 VDK67146.1 - 0.0083 15.8 16.3 0.095 12.4 3.1 3.4 3 0 0 3 3 3 2 GAG-polyprotein viral zinc-finger Ribosomal_L22 PF00237.19 VDK67146.1 - 0.048 13.9 0.2 0.33 11.2 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L22p/L17e zf-CCHC_4 PF14392.6 VDK67146.1 - 1.4 8.7 24.3 2.6 7.9 0.4 4.3 4 0 0 4 4 4 0 Zinc knuckle ABC_tran_Xtn PF12848.7 VDK67146.1 - 3.4 7.7 8.7 0.14 12.2 2.9 1.7 2 0 0 2 2 2 0 ABC transporter Ank_2 PF12796.7 VDK67147.1 - 4.2e-23 81.7 8.3 1.1e-14 54.8 5.0 3.9 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 VDK67147.1 - 4e-19 68.1 8.0 1.1e-05 25.6 0.2 5.2 4 1 1 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 VDK67147.1 - 2.1e-18 64.5 2.4 0.00092 19.5 0.1 5.2 4 1 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 VDK67147.1 - 4.8e-18 65.3 1.0 1.1e-08 35.4 0.1 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK67147.1 - 5.2e-15 55.3 4.6 1.2e-06 28.6 0.1 4.4 2 2 3 5 5 5 3 Ankyrin repeats (many copies) KN_motif PF12075.8 VDK67147.1 - 0.0057 16.4 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 KN motif SelP_N PF04592.14 VDK67148.1 - 1.2e-13 51.0 0.0 1.2e-13 51.0 0.0 3.1 2 1 1 3 3 3 1 Selenoprotein P, N terminal region AhpC-TSA PF00578.21 VDK67148.1 - 0.015 15.2 0.2 0.056 13.4 0.0 2.0 2 0 0 2 2 2 0 AhpC/TSA family Aldo_ket_red PF00248.21 VDK67149.1 - 3.8e-06 26.3 0.1 6.2e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Caenor_Her-1 PF09232.10 VDK67150.1 - 6.8e-35 120.1 9.7 7.6e-35 119.9 9.7 1.0 1 0 0 1 1 1 1 Caenorhabditis elegans Her-1 Tim17 PF02466.19 VDK67151.1 - 0.064 13.6 0.3 0.13 12.6 0.3 1.5 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Neur_chan_LBD PF02931.23 VDK67152.1 - 2.1e-06 27.4 3.9 1.1e-05 24.9 0.7 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Myosin_head PF00063.21 VDK67153.1 - 3.7e-151 504.6 1.9 5.6e-99 332.2 0.1 2.2 1 1 1 2 2 2 2 Myosin head (motor domain) Myosin-VI_CBD PF16521.5 VDK67153.1 - 4.9e-18 64.9 0.0 2.5e-17 62.6 0.0 2.2 2 0 0 2 2 2 1 Myosin VI cargo binding domain IQ PF00612.27 VDK67153.1 - 0.0042 16.8 2.5 0.014 15.1 2.5 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif TSC22 PF01166.18 VDK67153.1 - 0.0077 16.5 0.3 0.049 13.9 0.3 2.5 2 0 0 2 2 2 1 TSC-22/dip/bun family AAA_16 PF13191.6 VDK67153.1 - 0.013 15.9 0.1 0.062 13.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Myosin_N PF02736.19 VDK67153.1 - 0.038 13.8 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_11 PF13086.6 VDK67153.1 - 1.8 8.3 5.5 55 3.4 6.0 2.4 2 0 0 2 2 2 0 AAA domain Patched PF02460.18 VDK67156.1 - 4e-188 627.2 22.3 3.1e-114 382.8 9.5 2.0 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK67156.1 - 3.2e-10 40.0 0.6 3.2e-10 40.0 0.6 3.6 3 1 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation PH PF00169.29 VDK67157.1 - 5.2e-10 39.8 0.3 1.1e-09 38.8 0.3 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 VDK67157.1 - 0.013 15.8 0.1 0.039 14.3 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain zf-RING_9 PF13901.6 VDK67158.1 - 2e-58 197.8 14.7 4e-58 196.8 14.7 1.5 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon RUN PF02759.19 VDK67158.1 - 4.5e-24 84.9 0.3 2e-23 82.8 0.0 2.2 2 0 0 2 2 2 1 RUN domain TRIF-NTD PF17798.1 VDK67158.1 - 0.082 13.0 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 TRIF N-terminal domain zf-C3H2C3 PF17122.5 VDK67158.1 - 0.48 10.5 9.4 1.3 9.1 9.4 1.8 1 0 0 1 1 1 0 Zinc-finger Snf7 PF03357.21 VDK67159.1 - 7.3e-51 172.2 14.1 1.2e-50 171.4 14.1 1.4 1 0 0 1 1 1 1 Snf7 Citrate_synt PF00285.21 VDK67159.1 - 0.021 13.9 0.0 0.042 12.9 0.0 1.5 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain SYF2 PF08231.12 VDK67159.1 - 0.031 14.7 5.9 0.054 13.9 5.9 1.5 1 0 0 1 1 1 0 SYF2 splicing factor DAGK_acc PF00609.19 VDK67163.1 - 3.4e-44 151.0 0.0 6.8e-44 150.0 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 VDK67163.1 - 1.7e-29 102.0 0.0 3.6e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 VDK67163.1 - 2.1e-08 33.9 31.8 9.6e-08 31.8 18.5 2.9 2 1 1 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) ADK_lid PF05191.14 VDK67163.1 - 1.8 8.6 7.4 17 5.5 2.0 2.9 2 1 0 2 2 2 0 Adenylate kinase, active site lid zf-CCHC_5 PF14787.6 VDK67163.1 - 2.1 8.1 7.9 4.8 7.0 1.6 2.8 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Motile_Sperm PF00635.26 VDK67164.1 - 6e-11 42.2 0.0 1.2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF3767 PF12597.8 VDK67164.1 - 0.09 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) ASC PF00858.24 VDK67165.1 - 5.1e-61 207.0 14.7 3.7e-47 161.3 7.4 2.4 2 0 0 2 2 2 2 Amiloride-sensitive sodium channel DUF2229 PF09989.9 VDK67165.1 - 0.032 13.9 0.2 0.081 12.6 0.2 1.6 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Collagen PF01391.18 VDK67166.1 - 2.1e-21 75.5 93.9 1.2e-09 37.8 37.7 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK67166.1 - 3.9e-14 52.4 0.0 5.3e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain DnaJ PF00226.31 VDK67167.1 - 8.5e-19 67.5 1.0 2.2e-18 66.2 1.0 1.7 1 0 0 1 1 1 1 DnaJ domain DUF3793 PF12672.7 VDK67167.1 - 0.0038 17.3 0.1 0.011 15.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3793) Dynactin_p22 PF07426.11 VDK67167.1 - 0.6 9.9 6.7 4.4 7.1 6.7 2.1 1 1 0 1 1 1 0 Dynactin subunit p22 Neur_chan_LBD PF02931.23 VDK67168.1 - 9e-10 38.4 7.3 1.9e-08 34.0 7.3 2.4 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Red1 PF07964.11 VDK67169.1 - 5.9 5.0 34.3 7.3 4.7 34.3 1.1 1 0 0 1 1 1 0 Rec10 / Red1 LAP1C PF05609.12 VDK67169.1 - 6.7 5.7 26.6 8.2 5.4 26.6 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) FoP_duplication PF13865.6 VDK67172.1 - 2.2e-06 28.1 0.5 6.6e-06 26.6 0.0 2.0 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Corona_nucleoca PF00937.18 VDK67174.1 - 1.7 7.6 10.7 2.3 7.2 10.7 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF3439 PF11921.8 VDK67331.1 - 0.04 13.9 1.2 0.04 13.9 1.2 2.9 2 1 2 4 4 4 0 Domain of unknown function (DUF3439) Y_phosphatase PF00102.27 VDK67332.1 - 2.7e-70 236.6 1.8 4.4e-70 235.9 1.8 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK67332.1 - 1.1e-06 28.5 0.2 3.2e-06 27.0 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK67332.1 - 0.00011 22.2 0.0 0.0002 21.4 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 VDK67332.1 - 0.0061 16.7 0.0 0.017 15.2 0.0 1.9 1 1 0 1 1 1 1 Inositol hexakisphosphate C9orf72-like PF15019.6 VDK67333.1 - 7.2e-41 140.3 0.0 1.1e-40 139.8 0.0 1.3 1 0 0 1 1 1 1 C9orf72-like protein family NOC3p PF07540.11 VDK67333.1 - 0.079 13.4 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 Nucleolar complex-associated protein Thioredox_DsbH PF03190.15 VDK67335.1 - 4.3e-73 244.6 0.0 7.9e-73 243.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 VDK67335.1 - 7.4e-08 32.5 0.0 1.8e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like Guanylate_cyc PF00211.20 VDK67337.1 - 1.8e-55 187.4 0.0 3.6e-55 186.4 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 VDK67337.1 - 3.8e-39 134.8 2.0 5.1e-38 131.1 2.0 2.1 1 1 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.17 VDK67337.1 - 8.2e-19 67.9 0.0 4.2e-18 65.6 0.0 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 VDK67337.1 - 1.7e-17 63.7 0.0 4.9e-17 62.2 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Peripla_BP_6 PF13458.6 VDK67337.1 - 8.9e-06 25.6 0.0 0.00079 19.2 0.0 2.1 2 0 0 2 2 2 1 Periplasmic binding protein HNOBA PF07701.14 VDK67337.1 - 0.0052 16.2 0.6 0.011 15.2 0.6 1.5 1 0 0 1 1 1 1 Heme NO binding associated Glyoxal_oxid_N PF07250.11 VDK67337.1 - 0.035 13.3 0.1 0.079 12.1 0.1 1.5 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus DUF745 PF05335.13 VDK67337.1 - 0.085 12.6 2.0 0.083 12.6 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Vps35 PF03635.17 VDK67338.1 - 5.6e-265 881.4 13.6 6.4e-265 881.2 13.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Glyco_transf_21 PF13506.6 VDK67339.1 - 3.7e-40 137.2 0.0 5.2e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 VDK67339.1 - 8.8e-09 35.6 0.0 1.1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 VDK67339.1 - 2.7e-05 24.2 1.5 5.1e-05 23.3 1.5 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Cas6 PF09559.10 VDK67340.1 - 0.099 12.6 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cas6 Crispr TPR_12 PF13424.6 VDK67341.1 - 1.3e-07 31.7 0.1 4.8e-06 26.8 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK67341.1 - 0.00028 20.8 2.0 4.1 7.8 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK67341.1 - 0.0017 18.4 0.1 4.2 7.8 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat HemY_N PF07219.13 VDK67341.1 - 0.019 15.1 0.2 2.6 8.3 0.0 2.7 2 0 0 2 2 2 0 HemY protein N-terminus TPR_1 PF00515.28 VDK67341.1 - 0.021 14.6 0.8 2 8.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK67341.1 - 0.69 10.5 3.2 3.3 8.3 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DB PF01682.19 VDK67342.1 - 4.7e-14 52.5 14.1 4.7e-14 52.5 14.1 2.0 1 1 1 2 2 2 2 DB module Ank_2 PF12796.7 VDK67344.1 - 8.5e-26 90.4 3.0 6.1e-11 42.8 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK67344.1 - 2e-20 72.9 2.0 3.8e-09 36.9 0.9 4.8 2 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK67344.1 - 6.2e-19 67.8 5.0 3.8e-07 30.2 0.3 5.0 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 VDK67344.1 - 8.3e-17 60.8 7.4 3.9e-06 27.1 0.5 6.1 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 VDK67344.1 - 7.5e-13 47.4 4.0 0.021 15.3 0.3 6.9 7 0 0 7 7 7 3 Ankyrin repeat SAM_1 PF00536.30 VDK67344.1 - 4.6e-12 46.2 0.2 1.8e-11 44.3 0.2 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK67344.1 - 1.2e-11 44.5 0.1 2.9e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_6 PF17820.1 VDK67344.1 - 2.3e-11 43.4 0.1 4.5e-10 39.2 0.0 3.0 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.24 VDK67344.1 - 5.5e-08 33.0 0.1 5.6e-07 29.8 0.0 2.6 2 1 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 VDK67344.1 - 0.00074 19.8 0.1 0.0031 17.8 0.1 2.1 2 0 0 2 2 2 1 PDZ domain SAM_PNT PF02198.16 VDK67344.1 - 0.071 13.1 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain PID PF00640.23 VDK67347.1 - 3.9e-11 43.1 0.4 7.1e-11 42.3 0.4 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 VDK67347.1 - 0.0013 18.8 0.0 0.003 17.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 VDK67347.1 - 0.0021 17.9 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) Spermine_synth PF01564.17 VDK67348.1 - 9.5e-64 214.3 0.0 1.4e-63 213.7 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 VDK67348.1 - 4.8e-19 68.0 0.0 2.9e-18 65.5 0.0 2.1 2 0 0 2 2 2 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 VDK67348.1 - 0.00015 22.4 0.0 0.00028 21.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.16 VDK67348.1 - 0.00082 18.7 0.0 0.0012 18.1 0.0 1.2 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Methyltransf_12 PF08242.12 VDK67348.1 - 0.0068 17.1 0.0 0.027 15.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 VDK67348.1 - 0.018 14.6 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain RrnaAD PF00398.20 VDK67348.1 - 0.036 13.1 0.0 0.056 12.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_30 PF05430.11 VDK67348.1 - 0.047 13.6 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase ING PF12998.7 VDK67350.1 - 1.2e-14 54.7 0.9 1.2e-14 54.7 0.9 1.8 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 VDK67350.1 - 1.3e-05 24.9 8.5 2.4e-05 24.1 8.5 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 VDK67350.1 - 0.02 15.1 2.7 0.04 14.2 2.7 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain DUF4423 PF14394.6 VDK67350.1 - 0.022 14.5 0.6 1.1 8.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) ORC6 PF05460.13 VDK67350.1 - 1.1 8.4 5.5 2.1 7.5 5.5 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) RRM_1 PF00076.22 VDK67355.1 - 1.3e-58 194.7 0.0 2.1e-21 75.5 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK67355.1 - 2.3e-09 36.9 0.0 1.4e-05 24.7 0.0 3.7 3 1 1 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK67355.1 - 0.0016 18.3 0.1 6.7 6.6 0.0 3.8 4 0 0 4 4 4 1 Occluded RNA-recognition motif Colicin PF01024.19 VDK67355.1 - 0.0024 17.8 0.1 0.0045 16.9 0.1 1.4 1 0 0 1 1 1 1 Colicin pore forming domain RRM_3 PF08777.11 VDK67355.1 - 0.023 14.7 0.0 2.4 8.3 0.0 3.2 3 0 0 3 3 3 0 RNA binding motif 7tm_2 PF00002.24 VDK67357.1 - 4.2e-38 131.0 21.7 7.5e-26 90.9 6.8 2.3 1 1 1 2 2 2 2 7 transmembrane receptor (Secretin family) Gal_Lectin PF02140.18 VDK67357.1 - 6e-10 39.4 0.5 4e-09 36.8 0.5 2.6 1 0 0 1 1 1 1 Galactose binding lectin domain GPS PF01825.21 VDK67357.1 - 1.1e-09 38.6 1.9 1.1e-09 38.6 1.9 3.5 2 1 0 2 2 2 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 VDK67357.1 - 3.8e-06 26.5 1.7 9.6e-06 25.2 0.1 2.1 2 0 0 2 2 2 1 GPCR-Autoproteolysis INducing (GAIN) domain Lectin_C PF00059.21 VDK67357.1 - 0.0035 18.1 13.8 3.6 8.4 0.4 3.9 2 1 1 3 3 3 3 Lectin C-type domain Ig_3 PF13927.6 VDK67358.1 - 1.5e-18 67.1 0.3 1.4e-11 44.9 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 VDK67358.1 - 1.3e-13 50.8 0.0 1.1e-08 35.0 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 VDK67358.1 - 7.9e-13 48.4 0.2 7.5e-09 35.6 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 VDK67358.1 - 4.9e-11 42.8 0.3 9.5e-07 29.1 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 VDK67358.1 - 1.1e-09 38.5 0.7 0.00032 20.8 0.1 2.8 2 1 1 3 3 3 2 Immunoglobulin V-set domain Ig_4 PF16680.5 VDK67358.1 - 0.0021 18.3 0.1 0.97 9.7 0.0 2.8 2 1 1 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 VDK67358.1 - 0.0025 17.3 0.0 0.15 11.7 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin domain Herpes_gE PF02480.16 VDK67358.1 - 0.012 14.4 0.0 1.6 7.3 0.0 2.0 1 1 1 2 2 2 0 Alphaherpesvirus glycoprotein E Ig_C17orf99 PF17736.1 VDK67358.1 - 0.015 15.4 0.0 0.079 13.0 0.0 2.1 3 0 0 3 3 3 0 C17orf99 Ig domain C2-set_2 PF08205.12 VDK67358.1 - 0.025 14.6 0.1 0.44 10.6 0.0 2.2 2 0 0 2 2 2 0 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 VDK67358.1 - 0.1 13.0 0.0 5.7 7.4 0.0 2.7 2 1 0 2 2 2 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain PMP22_Claudin PF00822.20 VDK67381.1 - 0.0022 17.9 1.5 0.0044 16.9 1.5 1.4 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family TMEM37 PF15108.6 VDK67381.1 - 0.035 14.0 1.0 0.055 13.3 1.0 1.2 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family Claudin_2 PF13903.6 VDK67382.1 - 2.3e-06 27.5 6.0 2.7e-06 27.3 6.0 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 VDK67382.1 - 0.00017 21.5 2.7 0.00021 21.2 2.7 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin family SUR7 PF06687.12 VDK67382.1 - 0.00086 19.0 5.5 0.001 18.8 5.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family Amastin PF07344.11 VDK67382.1 - 0.013 15.3 2.9 0.016 15.0 2.9 1.1 1 0 0 1 1 1 0 Amastin surface glycoprotein PalH PF08733.10 VDK67382.1 - 0.33 9.9 5.6 0.43 9.5 5.6 1.1 1 0 0 1 1 1 0 PalH/RIM21 DUF1673 PF07895.11 VDK67382.1 - 0.72 9.5 3.8 1 9.1 3.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Glyco_transf_10 PF00852.19 VDK67383.1 - 2.6e-47 160.8 14.7 1.3e-46 158.5 4.6 2.4 3 0 0 3 3 3 2 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 VDK67383.1 - 2.8e-28 98.6 0.2 8.1e-28 97.1 0.2 1.8 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal G-patch PF01585.23 VDK67384.1 - 3.4e-11 42.8 1.9 6.8e-11 41.9 1.9 1.5 1 0 0 1 1 1 1 G-patch domain Rod_C PF10493.9 VDK67389.1 - 1.6e-23 83.0 12.7 4e-23 81.6 12.7 1.6 1 0 0 1 1 1 1 Rough deal protein C-terminal region Pecanex_C PF05041.15 VDK67390.1 - 1.1e-109 365.3 0.0 1.9e-109 364.6 0.0 1.3 1 0 0 1 1 1 1 Pecanex protein (C-terminus) DUF3460 PF11943.8 VDK67390.1 - 0.022 15.0 0.0 0.054 13.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3460) muHD PF10291.9 VDK67391.1 - 1.8e-44 152.2 0.1 2.8e-44 151.5 0.1 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 VDK67391.1 - 6.2e-09 36.0 0.5 2.8e-08 33.9 0.5 2.2 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain GrpE PF01025.19 VDK67391.1 - 3 7.5 7.7 0.66 9.6 1.2 2.5 1 1 1 2 2 2 0 GrpE Ctr PF04145.15 VDK67392.1 - 8.5e-21 75.1 13.4 2.2e-19 70.5 13.4 2.1 1 1 0 1 1 1 1 Ctr copper transporter family ERGIC_N PF13850.6 VDK67392.1 - 3.5 8.0 7.5 0.31 11.4 0.9 2.3 1 1 1 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) TFIIE_alpha PF02002.17 VDK67393.1 - 2.5e-16 59.4 6.4 5.8e-16 58.3 6.4 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 VDK67393.1 - 2.1e-10 40.8 3.1 6e-10 39.3 3.1 1.8 1 0 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha DUF3654 PF12376.8 VDK67393.1 - 0.021 15.0 6.8 0.039 14.1 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3654) zf-C2HE PF16278.5 VDK67393.1 - 0.12 12.8 0.4 5.5 7.5 0.0 2.8 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DZR PF12773.7 VDK67393.1 - 0.17 12.0 0.6 0.55 10.3 0.6 1.9 1 1 0 1 1 1 0 Double zinc ribbon NAC PF01849.18 VDK67394.1 - 2.9e-24 84.8 0.3 6e-24 83.8 0.3 1.6 1 0 0 1 1 1 1 NAC domain DUF974 PF06159.13 VDK67397.1 - 8.1e-73 245.2 0.1 1e-72 244.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Trs65 PF12735.7 VDK67397.1 - 8.4e-07 28.7 0.0 0.0024 17.3 0.0 3.2 2 1 0 3 3 3 3 TRAPP trafficking subunit Trs65 Transglut_C PF00927.22 VDK67397.1 - 0.0017 18.5 0.5 0.89 9.7 0.0 3.5 3 1 0 3 3 3 1 Transglutaminase family, C-terminal ig like domain Packaging_FI PF14000.6 VDK67399.1 - 0.036 14.5 0.4 0.12 12.9 0.4 1.8 1 0 0 1 1 1 0 DNA packaging protein FI 2-oxoacid_dh PF00198.23 VDK67401.1 - 7.7e-79 264.4 0.5 1.1e-78 263.9 0.5 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 VDK67401.1 - 5.8e-20 70.9 0.6 1.6e-19 69.5 0.4 1.9 1 1 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 VDK67401.1 - 7.1e-17 61.5 0.6 1.7e-16 60.3 0.1 1.9 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 VDK67401.1 - 0.00064 19.5 1.0 0.95 9.3 0.2 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 VDK67401.1 - 0.073 13.8 0.3 3 8.6 0.1 2.4 2 0 0 2 2 2 0 HlyD family secretion protein PDZ PF00595.24 VDK67403.1 - 1.3e-08 35.1 0.6 0.0025 18.1 0.0 3.0 2 1 1 3 3 3 2 PDZ domain PDZ_2 PF13180.6 VDK67403.1 - 1.5e-08 34.9 0.1 0.003 17.9 0.0 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK67403.1 - 1.8e-08 34.1 0.0 0.0022 17.8 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 VDK67403.1 - 0.00083 19.3 0.0 0.35 10.8 0.0 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain Pkinase PF00069.25 VDK67404.1 - 4.5e-45 154.1 0.0 5.7e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK67404.1 - 3.7e-21 75.6 0.0 5.2e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK67404.1 - 0.084 12.8 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Neur_chan_LBD PF02931.23 VDK67407.1 - 7.7e-42 143.2 0.6 1.2e-41 142.6 0.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK67407.1 - 1.2e-28 100.7 2.1 1.8e-24 87.1 0.2 2.4 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region B12D PF06522.11 VDK67407.1 - 0.072 12.9 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit PAN_1 PF00024.26 VDK67410.1 - 7.7e-17 61.0 54.7 0.00032 20.6 2.9 7.6 7 0 0 7 7 7 7 PAN domain Dymeclin PF09742.9 VDK67475.1 - 5.2e-33 114.4 0.5 5e-24 84.7 0.5 2.0 1 1 1 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein Ldh_1_N PF00056.23 VDK67478.1 - 1.2e-43 148.6 0.4 1.8e-43 148.0 0.4 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 VDK67478.1 - 6.2e-26 91.3 0.2 1.5e-25 90.0 0.1 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain JAB PF01398.21 VDK67480.1 - 9e-18 64.4 0.0 1.5e-17 63.7 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 VDK67480.1 - 7.2e-12 45.7 0.3 1.2e-11 45.1 0.3 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function DUF726 PF05277.12 VDK67481.1 - 2.5e-118 395.0 5.6 3.2e-118 394.6 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Cutinase PF01083.22 VDK67481.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Cutinase Abhydrolase_2 PF02230.16 VDK67481.1 - 0.15 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DnaJ PF00226.31 VDK67482.1 - 0.00021 21.3 0.0 0.00033 20.7 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 VDK67482.1 - 0.0089 16.0 0.0 0.0094 16.0 0.0 1.2 1 0 0 1 1 1 1 Pam16 DUF1232 PF06803.12 VDK67483.1 - 3.2e-08 33.2 7.4 6.5e-08 32.2 7.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1232) zf-RING_UBOX PF13445.6 VDK67483.1 - 3.2e-07 30.3 6.6 3.2e-07 30.2 5.4 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK67483.1 - 8.9e-07 28.7 6.9 8.9e-07 28.7 6.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK67483.1 - 1.1e-06 28.4 10.0 2.2e-06 27.4 10.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK67483.1 - 4.5e-05 23.2 4.5 4.5e-05 23.2 4.5 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK67483.1 - 7.4e-05 22.6 10.1 0.00018 21.4 10.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 VDK67483.1 - 0.00013 22.2 10.3 0.00013 22.2 10.3 1.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 VDK67483.1 - 0.00015 21.9 12.8 0.00033 20.7 12.8 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 VDK67483.1 - 0.00097 19.0 7.9 0.0024 17.7 7.9 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 TerY_C PF15616.6 VDK67483.1 - 0.018 15.2 1.7 0.03 14.4 1.7 1.4 1 0 0 1 1 1 0 TerY-C metal binding domain zf-ANAPC11 PF12861.7 VDK67483.1 - 0.041 13.9 2.0 0.069 13.2 2.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FdhE PF04216.12 VDK67483.1 - 0.24 11.2 1.4 0.32 10.8 1.4 1.1 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Ras PF00071.22 VDK67484.1 - 7.2e-44 149.2 0.1 8.5e-44 149.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK67484.1 - 3.4e-17 62.8 0.0 5.9e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK67484.1 - 4.1e-07 29.6 0.0 5.3e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK67484.1 - 4.9e-05 23.3 0.8 0.066 13.1 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 VDK67484.1 - 0.002 18.2 0.1 0.0042 17.1 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Viral_helicase1 PF01443.18 VDK67484.1 - 0.016 15.0 0.3 2.7 7.7 0.0 2.2 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 VDK67484.1 - 0.028 14.8 0.1 0.11 12.9 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 VDK67484.1 - 0.034 13.7 0.3 0.31 10.5 0.2 2.4 1 1 0 1 1 1 0 Ferrous iron transport protein B MeaB PF03308.16 VDK67484.1 - 0.079 11.9 0.2 5.2 6.0 0.1 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 VDK67484.1 - 0.12 12.6 0.3 1.2 9.4 0.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 VDK67484.1 - 0.2 11.4 1.2 0.45 10.2 0.1 2.0 2 2 0 2 2 2 0 AAA domain Nop PF01798.18 VDK67486.1 - 2.6e-84 282.3 0.0 5.3e-84 281.3 0.0 1.5 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 VDK67486.1 - 3.9e-20 72.0 0.0 1.5e-19 70.1 0.0 2.1 1 0 0 1 1 1 1 NOP5NT (NUC127) domain PQ-loop PF04193.14 VDK67487.1 - 9.4e-37 124.6 10.4 9.2e-20 70.2 2.3 2.5 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 VDK67487.1 - 8.1e-05 23.5 0.8 0.14 12.9 0.0 2.7 3 0 0 3 3 3 2 ER lumen protein retaining receptor Cpn60_TCP1 PF00118.24 VDK67488.1 - 1.4e-156 522.0 16.1 1.6e-156 521.8 16.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HSP70 PF00012.20 VDK67489.1 - 3.1e-258 857.9 10.4 1.2e-229 763.5 7.7 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 VDK67489.1 - 1.5e-17 63.4 0.1 1.7e-15 56.7 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 VDK67489.1 - 0.0038 17.0 0.0 0.0093 15.7 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 VDK67489.1 - 0.023 14.2 0.1 2.9 7.3 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 VDK67489.1 - 0.051 14.0 4.3 14 6.2 0.1 3.8 4 1 0 4 4 4 0 Cell division protein FtsA Hydantoinase_A PF01968.18 VDK67489.1 - 0.072 12.3 0.9 0.27 10.4 0.1 2.4 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase Cnd1_N PF12922.7 VDK67489.1 - 0.33 10.8 2.6 0.66 9.8 2.6 1.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term HORMA PF02301.18 VDK67489.1 - 0.98 9.0 4.5 0.58 9.7 2.4 1.6 1 1 0 1 1 1 0 HORMA domain Cadherin PF00028.17 VDK67490.1 - 9.2e-124 404.2 0.1 3.2e-19 69.2 0.0 15.7 14 1 1 15 15 15 13 Cadherin domain Cadherin_2 PF08266.12 VDK67490.1 - 3.2e-06 26.9 0.0 1.8 8.5 0.0 7.5 7 1 0 7 7 7 1 Cadherin-like Cadherin_3 PF16184.5 VDK67490.1 - 1.5e-05 24.9 5.2 6.5 6.8 0.0 7.4 8 0 0 8 8 8 1 Cadherin-like RET_CLD1 PF17756.1 VDK67490.1 - 3.6e-05 24.0 0.2 1.1 9.6 0.0 6.5 10 0 0 10 10 10 1 RET Cadherin like domain 1 DUF1410 PF07198.11 VDK67490.1 - 0.054 14.0 0.0 0.2 12.2 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1410) Cadherin_pro PF08758.11 VDK67490.1 - 0.11 12.7 0.1 24 5.2 0.0 4.1 4 0 0 4 4 4 0 Cadherin prodomain like DUF3093 PF11292.8 VDK67490.1 - 0.18 12.1 0.3 14 5.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) Cadherin PF00028.17 VDK67491.1 - 2.7e-183 595.1 25.3 2.9e-18 66.1 0.0 17.5 16 1 1 17 17 17 15 Cadherin domain Laminin_G_2 PF02210.24 VDK67491.1 - 1.5e-24 86.9 0.2 2.9e-15 57.0 0.0 3.0 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 VDK67491.1 - 2e-23 83.0 0.0 1.3e-14 54.5 0.0 3.1 3 0 0 3 3 3 2 Laminin G domain Cadherin_2 PF08266.12 VDK67491.1 - 5.6e-11 42.1 0.0 15 5.5 0.0 11.0 11 1 0 11 11 11 0 Cadherin-like Cadherin_3 PF16184.5 VDK67491.1 - 2e-06 27.7 11.6 6.7 6.8 0.1 8.3 8 0 0 8 8 8 1 Cadherin-like EGF PF00008.27 VDK67491.1 - 1.3e-05 25.4 9.9 1.3e-05 25.4 9.9 5.4 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.7 VDK67491.1 - 0.002 18.7 7.4 0.002 18.7 7.4 5.5 5 0 0 5 5 4 3 Human growth factor-like EGF EGF_2 PF07974.13 VDK67491.1 - 0.0022 18.3 13.4 0.0022 18.3 13.4 5.3 5 0 0 5 5 4 2 EGF-like domain Polysacc_lyase PF14099.6 VDK67491.1 - 0.01 15.7 0.1 0.59 9.9 0.0 3.0 3 0 0 3 3 3 0 Polysaccharide lyase Cadherin_4 PF17803.1 VDK67491.1 - 0.011 16.3 16.8 14 6.4 0.0 8.3 8 0 0 8 8 7 0 Bacterial cadherin-like domain Glyco_hydro2_C5 PF18565.1 VDK67491.1 - 0.078 12.8 0.9 7.1 6.5 0.0 3.3 2 0 0 2 2 2 0 Glycoside hydrolase family 2 C-terminal domain 5 CcmD PF04995.14 VDK67491.1 - 0.25 11.4 8.0 0.58 10.3 8.0 1.6 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) ComGG PF14173.6 VDK67491.1 - 0.37 11.2 1.9 3.3 8.2 0.0 3.4 3 0 0 3 3 2 0 ComG operon protein 7 Metallopep PF12044.8 VDK67494.1 - 1.1e-08 34.1 0.1 1.7e-08 33.5 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase family Peptidase_M66 PF10462.9 VDK67494.1 - 0.18 10.8 2.6 2.1 7.2 0.4 2.2 2 0 0 2 2 2 0 Peptidase M66 TTR-52 PF01060.23 VDK67495.1 - 7.2e-25 87.5 0.0 8.9e-25 87.2 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family His_Phos_2 PF00328.22 VDK67496.1 - 3.2e-20 72.8 0.0 1.1e-11 44.8 0.1 3.1 1 1 2 3 3 3 3 Histidine phosphatase superfamily (branch 2) His_Phos_1 PF00300.22 VDK67496.1 - 0.0035 17.1 0.0 0.055 13.2 0.0 2.2 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Glycophorin_A PF01102.18 VDK67496.1 - 0.021 15.1 0.1 0.039 14.2 0.1 1.4 1 0 0 1 1 1 0 Glycophorin A DUF1676 PF07898.13 VDK67496.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DM PF00751.18 VDK67497.1 - 1.2e-22 79.6 9.3 1.9e-22 78.9 9.3 1.3 1 0 0 1 1 1 1 DM DNA binding domain Pep3_Vps18 PF05131.14 VDK67499.1 - 7e-29 100.6 0.1 1.9e-28 99.1 0.1 1.8 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 VDK67499.1 - 0.00015 21.6 3.0 0.00015 21.6 3.0 3.6 5 0 0 5 5 5 1 Region in Clathrin and VPS Rootletin PF15035.6 VDK67499.1 - 0.037 14.0 4.1 0.08 13.0 4.1 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion G6PD_C PF02781.16 VDK67499.1 - 0.047 12.9 0.0 0.11 11.7 0.0 1.6 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, C-terminal domain SOGA PF11365.8 VDK67499.1 - 0.62 11.2 10.8 0.049 14.7 2.5 3.0 3 0 0 3 3 3 0 Protein SOGA Filament PF00038.21 VDK67550.1 - 4.8e-66 223.5 46.7 5e-64 216.8 46.7 2.2 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 VDK67550.1 - 1.1e-10 41.9 0.0 2.1e-10 41.0 0.0 1.5 1 0 0 1 1 1 1 Lamin Tail Domain Myosin_tail_1 PF01576.19 VDK67550.1 - 0.0002 19.4 46.0 0.0044 14.9 45.7 2.7 1 1 0 1 1 1 1 Myosin tail ATG16 PF08614.11 VDK67550.1 - 0.00042 20.6 46.2 0.017 15.3 9.6 4.5 1 1 1 3 3 3 3 Autophagy protein 16 (ATG16) APG6_N PF17675.1 VDK67550.1 - 0.00043 20.8 50.9 0.16 12.5 7.3 4.6 1 1 3 4 4 4 3 Apg6 coiled-coil region Gp58 PF07902.11 VDK67550.1 - 0.00068 18.1 4.4 0.00068 18.1 4.4 2.0 1 1 0 2 2 2 1 gp58-like protein YabA PF06156.13 VDK67550.1 - 0.00093 19.8 33.3 0.43 11.2 1.5 5.7 2 2 4 6 6 6 3 Initiation control protein YabA TPR_MLP1_2 PF07926.12 VDK67550.1 - 0.0012 18.9 40.6 0.098 12.7 7.5 5.1 1 1 3 5 5 5 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 VDK67550.1 - 0.0028 17.7 3.2 0.0028 17.7 3.2 4.6 2 2 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_tran_CTD PF16326.5 VDK67550.1 - 0.0081 16.4 2.3 0.0081 16.4 2.3 5.6 4 2 1 5 5 5 2 ABC transporter C-terminal domain Bacillus_HBL PF05791.11 VDK67550.1 - 0.019 14.8 19.7 0.3 10.9 3.5 4.2 2 1 0 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) Spc7 PF08317.11 VDK67550.1 - 0.022 13.7 39.8 0.038 12.9 7.5 3.4 1 1 1 3 3 3 0 Spc7 kinetochore protein SNCAIP_SNCA_bd PF16700.5 VDK67550.1 - 0.025 14.3 0.5 0.025 14.3 0.5 2.8 4 0 0 4 4 2 0 Synphilin-1 alpha-Synuclein-binding domain TSC22 PF01166.18 VDK67550.1 - 0.026 14.8 1.3 0.026 14.8 1.3 5.6 5 1 2 7 7 7 0 TSC-22/dip/bun family Laminin_II PF06009.12 VDK67550.1 - 0.043 13.8 23.0 0.18 11.8 1.5 4.6 2 2 3 5 5 5 0 Laminin Domain II DUF447 PF04289.12 VDK67550.1 - 0.055 13.2 0.5 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF447) Prominin PF05478.11 VDK67550.1 - 0.14 10.1 19.8 0.0065 14.5 8.4 2.8 1 1 2 3 3 3 0 Prominin BLOC1_2 PF10046.9 VDK67550.1 - 1.4 9.3 20.3 1.4 9.3 0.5 5.2 3 2 4 7 7 7 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 VDK67550.1 - 1.6 8.6 41.6 2.5 8.0 3.5 6.9 4 2 1 6 6 6 0 Septum formation initiator Occludin_ELL PF07303.13 VDK67550.1 - 1.8 9.3 21.0 1.3 9.8 1.6 4.6 2 1 3 5 5 5 0 Occludin homology domain Golgin_A5 PF09787.9 VDK67550.1 - 2.6 7.5 48.2 0.018 14.5 9.2 3.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF4201 PF13870.6 VDK67550.1 - 3.6 7.3 38.4 0.036 13.8 4.8 4.7 2 2 1 4 4 4 0 Domain of unknown function (DUF4201) THP2 PF09432.10 VDK67550.1 - 5.6 7.0 17.0 5.2 7.1 0.1 4.2 3 2 0 3 3 3 0 Tho complex subunit THP2 Spc42p PF11544.8 VDK67550.1 - 5.7 7.0 17.2 0.31 11.0 3.2 4.0 3 0 0 3 3 3 0 Spindle pole body component Spc42p Prefoldin_2 PF01920.20 VDK67550.1 - 5.8 6.9 27.6 0.84 9.6 3.7 5.9 3 2 1 6 6 6 0 Prefoldin subunit KASH_CCD PF14662.6 VDK67550.1 - 7.2 6.4 38.4 0.023 14.5 9.3 3.8 1 1 2 3 3 1 0 Coiled-coil region of CCDC155 or KASH XhlA PF10779.9 VDK67550.1 - 8.4 6.7 19.7 4.7 7.5 1.9 4.3 4 0 0 4 4 3 0 Haemolysin XhlA EGF_2 PF07974.13 VDK67552.1 - 7.9e-05 22.9 24.4 0.039 14.3 4.9 3.8 3 1 0 3 3 3 3 EGF-like domain Laminin_EGF PF00053.24 VDK67552.1 - 0.00024 21.2 24.3 0.003 17.7 5.6 3.4 1 1 2 3 3 3 3 Laminin EGF domain CTV_P6 PF06706.11 VDK67552.1 - 0.012 15.3 0.4 0.021 14.5 0.4 1.5 1 0 0 1 1 1 0 Citrus tristeza virus 6-kDa protein I-EGF_1 PF18372.1 VDK67552.1 - 0.032 14.3 0.8 0.032 14.3 0.8 3.5 4 0 0 4 4 4 0 Integrin beta epidermal growth factor like domain 1 EB PF01683.18 VDK67552.1 - 0.072 13.4 21.6 73 3.8 11.4 3.9 1 1 2 3 3 3 0 EB module Cadherin_C_2 PF16492.5 VDK67552.1 - 0.094 13.5 2.2 0.1 13.4 0.5 1.8 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal EGF PF00008.27 VDK67552.1 - 0.59 10.5 17.3 7.2 7.0 1.9 4.3 3 2 0 3 3 3 0 EGF-like domain AA_permease PF00324.21 VDK67553.1 - 1.3e-65 221.9 54.6 9.9e-65 219.0 54.6 2.1 1 1 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 VDK67553.1 - 2.6e-25 89.3 3.4 6.4e-12 45.2 0.0 3.7 3 1 1 4 4 4 3 Solute carrier family 12 AA_permease_2 PF13520.6 VDK67553.1 - 6.5e-13 48.3 55.1 1.1e-12 47.5 55.1 1.4 1 0 0 1 1 1 1 Amino acid permease Filamin PF00630.19 VDK67554.1 - 1.7e-10 41.6 0.1 3.6e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 Filamin/ABP280 repeat NHL PF01436.21 VDK67554.1 - 4.1e-08 32.9 5.0 0.019 15.0 0.1 4.9 5 0 0 5 5 5 2 NHL repeat zf-RING_5 PF14634.6 VDK67554.1 - 1.5e-05 24.9 8.8 1.5e-05 24.9 8.8 3.3 4 0 0 4 4 4 1 zinc-RING finger domain zf-RING_2 PF13639.6 VDK67554.1 - 0.00011 22.5 10.0 0.00011 22.5 10.0 3.7 4 0 0 4 4 4 1 Ring finger domain zf-B_box PF00643.24 VDK67554.1 - 0.00051 20.1 7.0 0.00051 20.1 7.0 3.8 5 0 0 5 5 5 1 B-box zinc finger zf-C3HC4_3 PF13920.6 VDK67554.1 - 0.00085 19.1 8.9 0.00085 19.1 8.9 3.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK67554.1 - 0.0023 17.8 7.9 0.0023 17.8 7.9 3.8 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 VDK67554.1 - 0.0032 17.3 10.6 0.0032 17.3 10.6 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK67554.1 - 0.0035 17.3 5.5 0.0035 17.3 5.5 4.1 3 1 1 4 4 4 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 VDK67554.1 - 4.2 7.6 19.5 0.58 10.4 7.9 3.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING ERG2_Sigma1R PF04622.12 VDK67556.1 - 1.8e-23 83.0 0.0 2.4e-23 82.6 0.0 1.1 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein TPK_catalytic PF04263.16 VDK67557.1 - 2e-31 108.5 0.0 2.9e-31 108.0 0.0 1.2 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 VDK67557.1 - 1.5e-14 53.5 0.4 2.7e-14 52.6 0.4 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain SCPU PF05229.15 VDK67557.1 - 0.14 12.6 0.1 0.23 11.9 0.1 1.3 1 0 0 1 1 1 0 Spore Coat Protein U domain NUC173 PF08161.12 VDK67558.1 - 2.2e-45 154.8 1.0 8.1e-45 153.0 0.2 2.5 2 0 0 2 2 2 1 NUC173 domain HEAT PF02985.22 VDK67558.1 - 0.07 13.4 5.7 0.96 9.9 0.1 5.0 4 0 0 4 4 4 0 HEAT repeat DUF1768 PF08719.11 VDK67560.1 - 1.1e-13 51.8 0.0 1.8e-13 51.0 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1768) GIDA_assoc PF13932.6 VDK67563.1 - 0.023 14.9 3.1 0.04 14.1 3.1 1.4 1 0 0 1 1 1 0 GidA associated domain DUF3585 PF12130.8 VDK67567.1 - 9.7e-11 42.0 19.5 6.3e-10 39.3 19.5 2.5 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 VDK67567.1 - 2.2e-06 27.8 0.0 1.5e-05 25.1 0.0 2.5 2 0 0 2 2 1 1 Calponin homology (CH) domain FAD_binding_2 PF00890.24 VDK67567.1 - 0.0003 20.0 0.1 0.00053 19.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 VDK67567.1 - 0.00033 20.0 0.1 0.0011 18.3 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase LIM PF00412.22 VDK67567.1 - 0.00087 19.5 5.5 0.0029 17.8 5.5 2.0 1 0 0 1 1 1 1 LIM domain FAD_binding_3 PF01494.19 VDK67567.1 - 0.00098 18.5 0.0 0.0032 16.8 0.0 1.9 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 VDK67567.1 - 0.0024 17.2 0.0 0.0081 15.4 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 VDK67567.1 - 0.0035 16.1 1.1 0.018 13.8 0.0 2.7 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 VDK67567.1 - 0.0055 16.1 0.1 0.015 14.7 0.1 1.8 1 0 0 1 1 1 1 FAD dependent oxidoreductase YppG PF14179.6 VDK67567.1 - 0.035 14.8 0.1 0.14 12.8 0.1 2.0 1 0 0 1 1 1 0 YppG-like protein Pyr_redox PF00070.27 VDK67567.1 - 0.054 14.0 3.1 0.1 13.2 0.0 3.2 4 0 0 4 4 2 0 Pyridine nucleotide-disulphide oxidoreductase T3SS_needle_E PF08988.10 VDK67567.1 - 0.064 13.4 0.4 8.3 6.6 0.0 3.0 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle CAMSAP_CH PF11971.8 VDK67567.1 - 0.068 13.0 0.5 0.23 11.3 0.0 2.2 2 0 0 2 2 1 0 CAMSAP CH domain DAO PF01266.24 VDK67567.1 - 0.096 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Condensin2nSMC PF12422.8 VDK67569.1 - 8.1e-25 87.8 0.3 3.5e-24 85.7 0.3 2.2 1 0 0 1 1 1 1 Condensin II non structural maintenance of chromosomes subunit HEAT PF02985.22 VDK67569.1 - 0.00048 20.2 0.7 3 8.3 0.0 4.9 4 0 0 4 4 4 1 HEAT repeat CLASP_N PF12348.8 VDK67569.1 - 0.018 14.6 0.1 0.22 11.0 0.0 2.9 2 1 0 2 2 2 0 CLASP N terminal MBOAT PF03062.19 VDK67603.1 - 4.7e-50 170.9 19.9 4.7e-50 170.9 19.9 1.9 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family ABC_membrane PF00664.23 VDK67605.1 - 1.6e-50 172.3 13.6 4.7e-13 49.4 3.6 4.5 2 2 2 4 4 4 4 ABC transporter transmembrane region ABC_tran PF00005.27 VDK67605.1 - 3.3e-40 137.8 1.2 8.5e-19 68.4 0.0 3.2 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 VDK67605.1 - 1.1e-07 31.5 2.0 0.067 12.6 0.0 3.2 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 VDK67605.1 - 0.00094 19.3 0.2 0.0031 17.6 0.0 2.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 VDK67605.1 - 0.0036 17.4 2.5 0.0082 16.2 0.1 2.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase AAA_29 PF13555.6 VDK67605.1 - 0.032 14.0 0.0 0.33 10.7 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain NB-ARC PF00931.22 VDK67605.1 - 0.065 12.4 0.0 0.18 11.0 0.0 1.8 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 VDK67605.1 - 0.078 13.4 0.0 1 9.7 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AUX_IAA PF02309.16 VDK67605.1 - 0.1 12.4 0.6 0.21 11.4 0.6 1.4 1 0 0 1 1 1 0 AUX/IAA family Zeta_toxin PF06414.12 VDK67605.1 - 0.16 11.2 0.1 0.33 10.2 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin ABC_ATPase PF09818.9 VDK67605.1 - 0.19 10.5 0.4 7.1 5.3 0.1 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_22 PF13401.6 VDK67605.1 - 0.21 11.8 1.8 2.6 8.3 0.1 3.1 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 VDK67605.1 - 0.25 11.1 2.8 0.7 9.6 0.3 2.6 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system LURAP PF14854.6 VDK67606.1 - 0.0029 17.5 0.3 0.0029 17.5 0.3 2.3 3 0 0 3 3 3 1 Leucine rich adaptor protein UPF0449 PF15136.6 VDK67606.1 - 0.1 13.1 2.1 1.9 9.0 0.6 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 SKA2 PF16740.5 VDK67606.1 - 0.15 11.8 2.8 1.8 8.4 0.4 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 FLYWCH PF04500.16 VDK67689.1 - 5.8e-10 39.1 0.2 1.2e-09 38.1 0.2 1.6 1 0 0 1 1 1 1 FLYWCH zinc finger domain Aminotran_5 PF00266.19 VDK67689.1 - 1.2e-07 31.1 0.0 1.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Neur_chan_LBD PF02931.23 VDK67694.1 - 7.8e-38 130.1 5.1 1.3e-37 129.3 5.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Hom_end_hint PF05203.16 VDK67694.1 - 0.13 12.2 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 Hom_end-associated Hint WD40 PF00400.32 VDK67695.1 - 1.9e-19 69.6 5.1 8.8e-06 26.4 0.1 6.2 6 0 0 6 6 6 3 WD domain, G-beta repeat Nup160 PF11715.8 VDK67695.1 - 0.0046 15.7 0.3 0.55 8.8 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Tocopherol_cycl PF14249.6 VDK67695.1 - 0.067 12.3 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Tocopherol cyclase Endonuclease_NS PF01223.23 VDK67696.1 - 1.7e-62 211.2 0.0 2.2e-62 210.8 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease HNHc_6 PF16784.5 VDK67696.1 - 0.026 14.1 0.2 0.056 13.0 0.2 1.6 1 1 0 1 1 1 0 Putative HNHc nuclease DUF1493 PF07377.12 VDK67696.1 - 0.034 14.6 0.0 0.077 13.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Endonuclea_NS_2 PF13930.6 VDK67696.1 - 0.16 12.1 0.9 0.76 9.9 0.9 1.9 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease Claudin_3 PF06653.11 VDK67697.1 - 0.011 15.6 8.2 0.019 14.9 8.2 1.3 1 0 0 1 1 1 0 Tight junction protein, Claudin-like Zona_pellucida PF00100.23 VDK67699.1 - 3.9e-16 59.6 4.9 6.1e-16 59.0 4.9 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Fis1_TPR_C PF14853.6 VDK67700.1 - 1.9e-20 72.6 1.2 4.1e-20 71.6 1.2 1.6 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 VDK67700.1 - 1.2e-06 28.0 0.2 3.1e-06 26.8 0.2 1.7 1 1 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_16 PF13432.6 VDK67700.1 - 0.00053 20.6 0.1 0.00093 19.8 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK67700.1 - 0.0099 16.1 1.0 0.025 14.8 0.7 1.8 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 VDK67700.1 - 0.017 15.2 0.4 0.041 14.0 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK67700.1 - 0.057 13.9 0.9 0.15 12.6 0.9 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK67700.1 - 0.065 13.3 1.1 0.2 11.8 0.4 2.2 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK67700.1 - 0.069 13.0 0.3 0.16 11.9 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK67700.1 - 0.27 12.1 1.5 2.2 9.3 0.3 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Acyltransferase PF01553.21 VDK67764.1 - 8e-30 103.2 0.2 1.1e-29 102.7 0.2 1.2 1 0 0 1 1 1 1 Acyltransferase Collagen PF01391.18 VDK67766.1 - 9.3e-24 83.0 81.7 7.4e-10 38.4 29.7 4.0 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Pepsin-I3 PF06394.13 VDK67767.1 - 1.3e-08 34.9 0.1 2.6e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 Pepsin inhibitor-3-like repeated domain Folate_carrier PF01770.18 VDK67768.1 - 2e-53 181.7 18.5 2.3e-53 181.4 18.5 1.0 1 0 0 1 1 1 1 Reduced folate carrier PHO4 PF01384.20 VDK67768.1 - 0.053 12.6 5.5 0.074 12.1 5.5 1.2 1 0 0 1 1 1 0 Phosphate transporter family Folate_carrier PF01770.18 VDK67769.1 - 5.6e-37 127.5 10.2 6.9e-37 127.2 10.2 1.0 1 0 0 1 1 1 1 Reduced folate carrier DUF735 PF05246.11 VDK67769.1 - 0.013 15.5 0.9 0.02 14.9 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF735) Atthog PF18800.1 VDK67769.1 - 0.56 10.1 6.1 0.6 10.0 4.9 1.7 1 1 0 1 1 1 0 Attenuator of Hedgehog Col_cuticle_N PF01484.17 VDK67769.1 - 1.1 9.4 0.1 1.1 9.4 0.1 3.1 4 0 0 4 4 4 0 Nematode cuticle collagen N-terminal domain Arm PF00514.23 VDK67770.1 - 1.4e-23 82.1 11.7 4.3e-05 23.4 0.1 7.6 8 1 0 8 8 8 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 VDK67770.1 - 2.6e-05 24.6 5.0 0.067 13.7 0.2 4.8 4 2 2 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.6 VDK67770.1 - 7.4e-05 23.1 0.1 0.29 11.5 0.0 3.6 1 1 3 4 4 4 2 HEAT repeats NopRA1 PF16201.5 VDK67770.1 - 0.0033 17.1 0.0 0.016 14.8 0.0 2.1 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 HEAT_PBS PF03130.16 VDK67770.1 - 0.083 13.6 2.0 93 4.2 0.2 4.8 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat HEAT PF02985.22 VDK67770.1 - 0.12 12.7 1.9 28 5.3 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat EB PF01683.18 VDK67771.1 - 1.8e-05 24.9 15.9 1.8e-05 24.9 15.9 13.4 7 3 4 13 13 13 2 EB module Sybindin PF04099.12 VDK67772.1 - 6.8e-25 87.7 0.1 8.3e-25 87.4 0.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Piwi PF02171.17 VDK67774.1 - 4.1e-113 377.6 0.0 6.7e-113 376.9 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 VDK67774.1 - 1.1e-26 94.1 0.0 2.4e-26 93.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoMid PF16487.5 VDK67774.1 - 8e-26 90.1 1.5 3.5e-25 88.1 0.4 2.6 2 1 0 2 2 2 1 Mid domain of argonaute PAZ PF02170.22 VDK67774.1 - 3.1e-25 88.6 0.4 5.1e-25 87.9 0.4 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 VDK67774.1 - 3e-22 78.0 0.1 6.3e-22 77.0 0.1 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 VDK67774.1 - 1.4e-09 38.1 0.1 5e-05 23.6 0.0 2.7 2 0 0 2 2 2 2 Argonaute linker 2 domain Motile_Sperm PF00635.26 VDK67777.1 - 1.3e-17 63.6 0.1 3.2e-17 62.4 0.1 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain fn3_6 PF17766.1 VDK67777.1 - 0.02 15.1 0.3 0.13 12.4 0.2 2.3 1 1 1 2 2 2 0 Fibronectin type-III domain DUF737 PF05300.11 VDK67777.1 - 0.078 13.3 6.4 0.16 12.3 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF737) UBA2_C PF16195.5 VDK67777.1 - 1.3 9.8 11.5 0.3 11.8 6.2 2.3 2 1 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus GATA PF00320.27 VDK67779.1 - 3.2e-12 45.9 8.4 6.4e-12 44.9 8.4 1.6 1 0 0 1 1 1 1 GATA zinc finger Ribosomal_L37ae PF01780.19 VDK67779.1 - 0.022 14.8 1.4 0.072 13.2 1.4 1.8 1 0 0 1 1 1 0 Ribosomal L37ae protein family eIF-5_eIF-2B PF01873.17 VDK67779.1 - 0.03 14.2 1.9 0.066 13.1 1.9 1.5 1 0 0 1 1 1 0 Domain found in IF2B/IF5 Syntaxin PF00804.25 VDK67782.1 - 7.7e-33 113.9 7.9 7.7e-33 113.9 7.9 1.4 2 0 0 2 2 2 1 Syntaxin Fez1 PF06818.15 VDK67782.1 - 0.0031 18.0 1.9 0.71 10.3 0.0 2.2 2 0 0 2 2 2 2 Fez1 VPS53_C PF16854.5 VDK67782.1 - 0.069 13.0 1.5 0.18 11.7 0.1 2.2 2 1 0 3 3 3 0 Vacuolar protein sorting-associated protein 53 C-terminus DUF2976 PF11190.8 VDK67782.1 - 0.11 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) 3-dmu-9_3-mt PF06983.13 VDK67782.1 - 0.14 12.7 0.0 0.44 11.1 0.0 1.8 1 0 0 1 1 1 0 3-demethylubiquinone-9 3-methyltransferase DUF4988 PF16378.5 VDK67782.1 - 0.21 11.2 1.0 0.46 10.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function RhoGEF PF00621.20 VDK67784.1 - 4.3e-37 128.1 2.9 4.4e-37 128.1 1.2 1.9 2 0 0 2 2 2 1 RhoGEF domain SH2 PF00017.24 VDK67784.1 - 1.2e-18 66.9 0.0 3.4e-18 65.5 0.0 1.8 1 0 0 1 1 1 1 SH2 domain CH PF00307.31 VDK67784.1 - 5.8e-16 58.6 0.2 1.9e-15 57.0 0.2 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain SH3_2 PF07653.17 VDK67784.1 - 5.8e-15 54.7 0.0 3.8e-10 39.3 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 VDK67784.1 - 1e-10 41.0 0.0 5.8e-09 35.4 0.0 2.5 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 VDK67784.1 - 5.9e-10 38.9 0.1 3.2e-09 36.5 0.1 2.2 2 0 0 2 2 2 1 Variant SH3 domain CAMSAP_CH PF11971.8 VDK67784.1 - 1.7e-08 34.1 0.4 5.9e-08 32.4 0.4 1.9 1 0 0 1 1 1 1 CAMSAP CH domain C1_1 PF00130.22 VDK67784.1 - 1.6e-07 31.1 11.1 1.6e-07 31.1 11.1 2.3 2 0 0 2 2 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CDC24 PF06395.11 VDK67784.1 - 5.5e-05 23.3 0.1 0.00016 21.8 0.1 1.8 1 0 0 1 1 1 1 CDC24 Calponin PH PF00169.29 VDK67784.1 - 0.0013 19.3 0.0 0.0044 17.5 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 VDK67784.1 - 0.003 17.8 0.1 0.014 15.7 0.1 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain EnY2 PF10163.9 VDK67786.1 - 6.5e-27 93.7 0.4 7.4e-27 93.6 0.4 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 UPF0167 PF03691.14 VDK67786.1 - 0.028 14.2 0.1 0.032 14.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) Ribosomal_L3 PF00297.22 VDK67788.1 - 5.9e-181 601.4 12.2 6.9e-181 601.1 12.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 DUF1310 PF07006.11 VDK67788.1 - 0.054 13.5 0.0 0.19 11.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1310) MOLO1 PF17175.4 VDK67790.1 - 5.9e-21 74.8 0.2 2.6e-20 72.7 0.1 2.0 2 1 0 2 2 2 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 VDK67790.1 - 0.0013 18.9 0.1 0.005 17.0 0.1 2.0 1 1 0 1 1 1 1 TPM domain TRAUB PF08164.12 VDK67791.1 - 7.6e-27 93.7 2.2 7.6e-27 93.7 2.2 2.7 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 VDK67791.1 - 1.8e-20 74.0 7.9 1.8e-20 74.0 7.9 3.2 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor DUF3263 PF11662.8 VDK67791.1 - 0.053 13.4 0.2 0.16 11.8 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) zf-RING_9 PF13901.6 VDK67793.1 - 1.7e-62 211.1 9.2 3.5e-62 210.0 9.2 1.6 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon AAA PF00004.29 VDK67794.1 - 1.7e-84 280.8 0.0 5.1e-47 159.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK67794.1 - 3.3e-22 78.0 0.9 1e-09 38.0 0.1 3.2 3 0 0 3 3 3 2 AAA+ lid domain Nucleolin_bd PF16725.5 VDK67794.1 - 8.7e-16 57.3 0.2 1.8e-15 56.3 0.2 1.5 1 0 0 1 1 1 1 Nucleolin binding domain AAA_16 PF13191.6 VDK67794.1 - 2.7e-10 40.9 0.4 0.0017 18.7 0.0 4.3 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 VDK67794.1 - 1.8e-09 38.0 0.8 0.00094 19.5 0.0 4.5 2 2 1 3 3 3 2 AAA domain RuvB_N PF05496.12 VDK67794.1 - 3.6e-09 36.5 0.0 0.0001 22.1 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 VDK67794.1 - 1.4e-08 35.0 0.0 0.00053 20.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 VDK67794.1 - 1.9e-08 34.6 0.0 4.6e-05 23.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 VDK67794.1 - 5e-08 33.0 0.6 0.027 14.5 0.0 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 VDK67794.1 - 8.2e-07 29.4 0.0 0.04 14.3 0.0 3.2 2 1 1 3 3 3 2 RNA helicase IstB_IS21 PF01695.17 VDK67794.1 - 9.1e-07 28.8 0.1 0.0089 15.8 0.0 3.1 3 0 0 3 3 3 2 IstB-like ATP binding protein TIP49 PF06068.13 VDK67794.1 - 2.1e-06 27.2 0.2 0.0015 17.8 0.0 2.6 3 0 0 3 3 3 2 TIP49 P-loop domain Mg_chelatase PF01078.21 VDK67794.1 - 2.4e-06 27.1 0.2 0.034 13.5 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 VDK67794.1 - 3e-06 27.3 0.0 0.0029 17.6 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain Zeta_toxin PF06414.12 VDK67794.1 - 4.5e-06 26.1 0.0 0.0042 16.4 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin AAA_18 PF13238.6 VDK67794.1 - 5.7e-06 26.9 0.1 0.01 16.4 0.0 3.2 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 VDK67794.1 - 9.3e-06 25.7 1.2 0.23 11.4 0.2 3.9 3 1 0 3 3 3 2 NACHT domain AAA_14 PF13173.6 VDK67794.1 - 1.7e-05 24.9 0.0 0.013 15.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.10 VDK67794.1 - 3.1e-05 23.9 0.0 0.25 11.4 0.0 2.9 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TsaE PF02367.17 VDK67794.1 - 4e-05 23.6 0.0 0.22 11.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 VDK67794.1 - 5.3e-05 23.5 0.0 0.1 12.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 VDK67794.1 - 0.00019 21.9 0.0 0.36 11.3 0.0 3.4 2 1 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 VDK67794.1 - 0.00021 21.7 0.0 0.91 9.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 VDK67794.1 - 0.00042 19.7 2.3 1.3 8.3 0.0 3.8 4 0 0 4 4 4 2 KaiC Viral_helicase1 PF01443.18 VDK67794.1 - 0.00044 20.1 0.0 0.19 11.5 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 VDK67794.1 - 0.0008 19.3 0.0 0.49 10.3 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 VDK67794.1 - 0.00091 18.5 0.0 0.66 9.1 0.0 2.8 2 0 0 2 2 2 1 NB-ARC domain Sigma54_activat PF00158.26 VDK67794.1 - 0.0016 18.2 0.0 2.1 8.0 0.0 3.0 4 0 0 4 4 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 VDK67794.1 - 0.0023 17.5 0.6 3.1 7.3 0.0 3.1 4 0 0 4 4 3 2 AAA domain Sigma54_activ_2 PF14532.6 VDK67794.1 - 0.0024 18.0 0.0 3.5 7.7 0.0 2.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_7 PF12775.7 VDK67794.1 - 0.0031 17.1 0.0 1.2 8.6 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_11 PF13086.6 VDK67794.1 - 0.0038 17.1 0.0 1.1 9.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain Cytidylate_kin2 PF13189.6 VDK67794.1 - 0.0065 16.6 0.0 5.5 7.1 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase-like family PhoH PF02562.16 VDK67794.1 - 0.012 15.0 0.0 2.7 7.4 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 VDK67794.1 - 0.012 15.3 0.0 3.2 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 VDK67794.1 - 0.037 14.1 0.0 1.4 9.0 0.0 2.8 2 0 0 2 2 2 0 Shikimate kinase Parvo_NS1 PF01057.17 VDK67794.1 - 0.07 12.2 0.0 1.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NTPase_1 PF03266.15 VDK67794.1 - 0.075 12.9 0.0 6.7 6.6 0.0 3.0 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 VDK67794.1 - 0.08 12.7 0.0 4.2 7.1 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 VDK67794.1 - 0.092 11.9 0.0 3 6.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 VDK67794.1 - 0.18 12.1 0.2 16 5.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain Astacin PF01400.24 VDK67795.1 - 0.0003 20.5 0.0 0.093 12.3 0.0 2.2 1 1 1 2 2 2 2 Astacin (Peptidase family M12A) MFS_1 PF07690.16 VDK67796.1 - 1.5e-39 135.9 21.8 1.5e-39 135.9 21.8 2.7 1 1 2 3 3 3 2 Major Facilitator Superfamily FAD_binding_2 PF00890.24 VDK67798.1 - 2.8e-126 422.0 5.4 3.9e-126 421.5 5.4 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 VDK67798.1 - 1e-37 129.0 0.4 1.6e-37 128.3 0.4 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 VDK67798.1 - 5.2e-05 22.6 2.3 0.0015 17.8 0.8 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 VDK67798.1 - 0.00013 21.3 0.5 0.063 12.5 0.1 2.4 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 VDK67798.1 - 0.00087 19.0 0.3 0.0037 16.9 0.2 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 VDK67798.1 - 0.00095 18.0 0.1 0.0045 15.7 0.0 2.2 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 VDK67798.1 - 0.0023 17.1 4.3 0.24 10.5 3.5 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 VDK67798.1 - 0.0064 15.8 1.2 0.012 14.9 1.2 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 VDK67798.1 - 0.091 12.1 0.6 0.21 10.9 0.6 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase Vps52 PF04129.12 VDK67799.1 - 3.3e-111 372.5 18.9 7.7e-72 242.7 7.9 2.2 1 1 1 2 2 2 2 Vps52 / Sac2 family Sec3_C PF09763.9 VDK67799.1 - 1.7e-09 36.7 15.1 5.8e-06 25.0 9.5 2.4 2 1 0 2 2 2 2 Exocyst complex component Sec3 ASCH PF04266.14 VDK67799.1 - 0.013 16.1 0.2 0.11 13.1 0.1 2.4 2 0 0 2 2 2 0 ASCH domain Spc7 PF08317.11 VDK67799.1 - 0.022 13.6 8.1 0.015 14.2 5.3 2.0 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4901 PF16244.5 VDK67799.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4901) MukB PF04310.12 VDK67799.1 - 0.87 9.3 5.0 1.7 8.4 2.9 2.2 1 1 1 2 2 2 0 MukB N-terminal ING PF12998.7 VDK67799.1 - 1.4 9.5 10.2 1.6 9.4 0.0 4.3 3 1 2 5 5 5 0 Inhibitor of growth proteins N-terminal histone-binding TMC PF07810.13 VDK67800.1 - 7.4e-37 126.3 3.9 1.3e-36 125.5 2.6 2.2 2 0 0 2 2 2 1 TMC domain SNX17_FERM_C PF18116.1 VDK67802.1 - 5.1e-28 97.3 0.0 9.9e-28 96.3 0.0 1.5 1 0 0 1 1 1 1 Sorting Nexin 17 FERM C-terminal domain PX PF00787.24 VDK67802.1 - 9.2e-10 38.5 0.4 2.2e-09 37.3 0.4 1.6 1 0 0 1 1 1 1 PX domain SMC_N PF02463.19 VDK67804.1 - 1.3e-21 77.1 0.0 2.5e-21 76.1 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 VDK67804.1 - 5.6e-11 43.3 17.3 5.6e-11 43.3 17.3 4.9 3 2 0 3 3 2 1 AAA domain AAA_21 PF13304.6 VDK67804.1 - 2.1e-05 24.5 7.9 0.007 16.2 0.0 3.4 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 VDK67804.1 - 0.00048 20.0 16.6 0.00048 20.0 16.6 4.0 2 2 1 3 3 3 2 AAA ATPase domain AAA_25 PF13481.6 VDK67804.1 - 0.0034 17.0 1.9 0.05 13.2 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA_29 PF13555.6 VDK67804.1 - 0.024 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 VDK67804.1 - 0.22 11.4 1.6 2.3 8.1 0.0 3.3 4 0 0 4 4 4 0 NACHT domain ABC_tran PF00005.27 VDK67804.1 - 0.26 11.8 0.1 0.26 11.8 0.1 4.6 4 2 0 4 4 4 0 ABC transporter BLOC1_2 PF10046.9 VDK67804.1 - 1.1 9.6 27.2 0.38 11.1 1.5 5.3 5 1 0 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Aconitase_C PF00694.19 VDK67804.1 - 2.4 8.5 5.8 0.62 10.4 0.2 2.9 3 0 0 3 3 3 0 Aconitase C-terminal domain DUF4398 PF14346.6 VDK67804.1 - 5.7 7.6 10.7 3.2 8.5 2.5 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) Sec20 PF03908.13 VDK67804.1 - 5.8 6.9 18.9 0.18 11.7 1.2 4.9 4 1 2 6 6 6 0 Sec20 TTL PF03133.15 VDK67805.1 - 5.5e-59 199.7 0.5 8.5e-59 199.1 0.5 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 VDK67805.1 - 3.6e-07 29.7 0.0 0.00054 19.3 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATPgrasp_YheCD PF14398.6 VDK67805.1 - 2.5e-05 23.6 0.1 0.037 13.3 0.0 2.5 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATP-grasp_3 PF02655.14 VDK67805.1 - 0.0036 17.4 0.0 0.035 14.2 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 VDK67805.1 - 0.032 13.8 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 RimK-like ATP-grasp domain YEATS PF03366.16 VDK67806.1 - 3e-34 116.9 1.4 5.7e-34 115.9 1.4 1.5 1 0 0 1 1 1 1 YEATS family RPW8 PF05659.11 VDK67806.1 - 0.13 12.0 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Collagen PF01391.18 VDK67808.1 - 4.3e-20 71.2 73.9 2e-08 33.9 26.7 4.3 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Exonuc_X-T_C PF08411.10 VDK67808.1 - 0.081 12.0 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Exonuclease C-terminal DUF1980 PF09323.10 VDK67809.1 - 0.064 13.2 0.2 0.13 12.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Dcc1 PF09724.9 VDK67811.1 - 5.4e-62 210.0 2.8 6.3e-62 209.8 2.8 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Importin_rep_6 PF18829.1 VDK67811.1 - 0.021 14.9 0.3 0.13 12.4 0.1 2.2 2 0 0 2 2 2 0 Importin repeat 6 V-set_CD47 PF08204.11 VDK67811.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 CD47 immunoglobulin-like domain MRF_C2 PF13888.6 VDK67840.1 - 3.4e-38 130.7 0.2 9.5e-38 129.2 0.2 1.8 1 0 0 1 1 1 1 Myelin gene regulatory factor C-terminal domain 2 NDT80_PhoG PF05224.12 VDK67840.1 - 1.8e-23 83.7 2.4 2.5e-22 80.0 0.9 2.9 2 1 0 2 2 2 1 NDT80 / PhoG like DNA-binding family MRF_C1 PF13887.6 VDK67840.1 - 2.3e-16 58.7 0.1 4.5e-16 57.7 0.1 1.5 1 0 0 1 1 1 1 Myelin gene regulatory factor -C-terminal domain 1 Peptidase_S74 PF13884.6 VDK67840.1 - 1.8e-12 47.4 0.0 3.7e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Chaperone of endosialidase Mito_fiss_reg PF05308.11 VDK67842.1 - 0.017 15.2 1.0 0.018 15.1 1.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 VDK67842.1 - 0.043 13.8 6.3 0.057 13.4 6.3 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 VDK67842.1 - 0.055 13.0 5.9 0.067 12.7 5.9 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal VIR_N PF15912.5 VDK67842.1 - 0.25 10.9 4.1 0.36 10.4 4.1 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal zf-C3HC4 PF00097.25 VDK67844.1 - 0.0069 16.2 9.9 0.0069 16.2 9.9 5.2 4 1 0 4 4 4 3 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK67844.1 - 0.012 15.6 11.8 0.012 15.6 11.8 5.2 3 1 2 5 5 5 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 VDK67844.1 - 0.015 15.3 9.4 0.015 15.3 9.4 4.9 4 0 0 4 4 4 0 RING-type zinc-finger zf-C3HC4_5 PF17121.5 VDK67844.1 - 0.021 14.7 5.7 0.021 14.7 5.7 4.9 3 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK67844.1 - 0.029 14.7 12.0 0.029 14.7 12.0 5.2 3 1 2 5 5 5 0 Ring finger domain zf-C3HC4_2 PF13923.6 VDK67844.1 - 0.033 14.0 1.1 0.033 14.0 1.1 5.4 4 1 1 5 5 5 0 Zinc finger, C3HC4 type (RING finger) Peptidase_M41 PF01434.18 VDK67846.1 - 1.2e-65 220.9 0.5 2.2e-65 220.1 0.5 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 VDK67846.1 - 1.2e-45 155.2 0.0 3.7e-45 153.6 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK67846.1 - 3.5e-09 36.3 0.4 1.1e-08 34.7 0.1 2.1 2 0 0 2 2 1 1 AAA+ lid domain AAA_5 PF07728.14 VDK67846.1 - 8.7e-08 32.3 0.0 3.8e-07 30.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 VDK67846.1 - 2e-05 25.0 0.7 0.0042 17.5 0.1 2.8 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.12 VDK67846.1 - 2.4e-05 24.1 0.0 8e-05 22.4 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 VDK67846.1 - 0.00029 20.2 0.0 0.00076 18.8 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 VDK67846.1 - 0.0015 18.7 0.0 0.0045 17.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 VDK67846.1 - 0.0027 17.4 0.1 0.0081 15.9 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 VDK67846.1 - 0.0038 17.5 3.4 0.034 14.4 0.1 3.2 3 1 0 3 3 2 1 AAA domain AAA_14 PF13173.6 VDK67846.1 - 0.0042 17.1 0.0 0.016 15.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 VDK67846.1 - 0.0061 16.0 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 VDK67846.1 - 0.0075 16.8 0.3 0.09 13.3 0.0 2.7 3 0 0 3 3 2 1 ABC transporter AAA_7 PF12775.7 VDK67846.1 - 0.012 15.1 0.0 0.05 13.1 0.0 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 VDK67846.1 - 0.018 14.7 0.0 0.28 10.9 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_18 PF13238.6 VDK67846.1 - 0.03 14.9 0.1 0.21 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 VDK67846.1 - 0.036 14.2 0.0 0.084 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 VDK67846.1 - 0.048 13.9 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 VDK67846.1 - 0.051 14.0 0.1 0.25 11.8 0.0 2.3 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 VDK67846.1 - 0.062 13.0 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 VDK67846.1 - 0.079 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 VDK67846.1 - 0.082 13.2 0.2 0.33 11.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 VDK67846.1 - 0.12 11.7 0.1 0.41 9.9 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin Mago_nashi PF02792.14 VDK67849.1 - 2.6e-75 251.3 0.3 2.9e-75 251.2 0.3 1.0 1 0 0 1 1 1 1 Mago nashi protein MtN3_slv PF03083.16 VDK67851.1 - 1.7e-43 146.5 11.1 8.7e-23 80.2 0.7 2.3 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange Tim17 PF02466.19 VDK67852.1 - 5.4e-26 91.2 3.1 8.7e-26 90.5 2.8 1.5 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family AAA_2 PF07724.14 VDK67854.1 - 3.9e-37 128.0 0.0 7.5e-37 127.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 VDK67854.1 - 3.3e-12 47.0 0.1 8.7e-12 45.6 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 VDK67854.1 - 4.3e-08 33.1 0.7 1.4e-07 31.4 0.1 2.2 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein RuvB_N PF05496.12 VDK67854.1 - 0.00022 21.0 0.1 0.00063 19.5 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 VDK67854.1 - 0.00024 21.1 0.0 0.00056 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 VDK67854.1 - 0.00025 20.5 0.1 0.035 13.5 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM PF00493.23 VDK67854.1 - 0.00039 19.6 0.2 0.00073 18.7 0.2 1.4 1 0 0 1 1 1 1 MCM P-loop domain Sigma54_activat PF00158.26 VDK67854.1 - 0.0008 19.1 0.1 0.33 10.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 VDK67854.1 - 0.00091 19.5 0.0 0.0062 16.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 VDK67854.1 - 0.001 19.1 0.0 0.011 15.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 VDK67854.1 - 0.0011 18.7 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 VDK67854.1 - 0.011 16.1 0.0 0.075 13.4 0.0 2.2 1 1 1 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 VDK67854.1 - 0.015 15.9 0.0 0.048 14.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 VDK67854.1 - 0.018 15.0 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase PduV-EutP PF10662.9 VDK67854.1 - 0.052 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 VDK67854.1 - 0.058 13.4 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 VDK67854.1 - 0.14 12.7 0.5 0.56 10.7 0.0 2.3 2 1 0 2 2 2 0 ABC transporter Aldolase_II PF00596.21 VDK67854.1 - 0.15 12.0 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 Class II Aldolase and Adducin N-terminal domain FGGY_C PF02782.16 VDK67854.1 - 0.22 11.2 0.2 24 4.6 0.0 2.5 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain RRM_1 PF00076.22 VDK67856.1 - 6.4e-33 112.4 0.0 5.3e-18 64.6 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK67856.1 - 4.9e-08 32.9 0.0 0.0056 16.7 0.0 2.1 2 0 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 VDK67856.1 - 0.0079 16.3 0.0 0.027 14.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif Nup35_RRM_2 PF14605.6 VDK67856.1 - 0.14 12.2 0.0 0.7 9.9 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif LRR_8 PF13855.6 VDK67860.1 - 1.3e-17 63.3 27.2 5.8e-06 26.0 3.5 3.9 2 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 VDK67860.1 - 1.4e-15 57.2 25.6 2.4e-05 24.6 1.9 4.7 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) B3_4 PF03483.17 VDK67860.1 - 6.2e-08 32.5 0.1 1.7e-07 31.0 0.0 1.7 2 0 0 2 2 2 1 B3/4 domain LRR_9 PF14580.6 VDK67860.1 - 1.1e-05 25.0 15.7 0.00022 20.8 4.8 3.4 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 VDK67860.1 - 0.17 12.6 19.6 0.98 10.2 0.0 6.6 6 1 1 7 7 7 0 Leucine Rich Repeat Rcd1 PF04078.13 VDK67862.1 - 2.5e-130 433.4 0.8 2.8e-130 433.2 0.8 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like PCI PF01399.27 VDK67864.1 - 7.7e-11 42.4 2.3 2.4e-10 40.8 0.9 2.4 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 VDK67864.1 - 0.0013 18.4 1.6 0.0029 17.2 1.6 1.7 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix FliG_N PF14842.6 VDK67864.1 - 0.016 15.7 0.1 0.052 14.1 0.1 1.9 1 0 0 1 1 1 0 FliG N-terminal domain Ribosomal_S5_C PF03719.15 VDK67866.1 - 2.9e-18 65.1 0.0 1e-17 63.4 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 VDK67866.1 - 8.2e-17 60.9 0.3 1.4e-16 60.2 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Lyase_catalyt PF09093.11 VDK67866.1 - 0.021 14.0 0.0 0.032 13.4 0.0 1.2 1 0 0 1 1 1 0 Lyase, catalytic NLRC4_HD2 PF17776.1 VDK67866.1 - 0.024 15.2 0.0 0.064 13.8 0.0 1.7 1 0 0 1 1 1 0 NLRC4 helical domain HD2 Sel1 PF08238.12 VDK67869.1 - 1.3e-55 184.6 44.0 6.4e-08 33.0 0.0 12.1 12 0 0 12 12 12 10 Sel1 repeat TipAS PF07739.13 VDK67869.1 - 0.0016 19.0 5.9 0.61 10.6 1.4 3.9 3 1 1 4 4 4 2 TipAS antibiotic-recognition domain TAP_C PF03943.13 VDK67869.1 - 0.028 14.1 0.9 3.1 7.5 0.0 3.8 4 0 0 4 4 4 0 TAP C-terminal domain LBP_BPI_CETP PF01273.25 VDK67870.1 - 3.5e-14 52.7 0.1 8.3e-14 51.5 0.1 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 VDK67872.1 - 5.9e-22 78.3 0.2 1.1e-21 77.4 0.2 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 VDK67872.1 - 3.1e-15 56.2 0.0 7.7e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain PDZ PF00595.24 VDK67873.1 - 3.4e-27 94.6 4.1 7.1e-10 39.1 0.1 3.6 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 VDK67873.1 - 3.2e-15 55.7 0.7 0.00033 20.4 0.1 3.5 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 VDK67873.1 - 2.8e-09 37.2 0.4 2.4e-05 24.6 0.1 3.6 3 0 0 3 3 3 1 PDZ domain Par3_HAL_N_term PF12053.8 VDK67873.1 - 1.1e-07 32.0 0.2 2.6e-07 30.7 0.2 1.6 1 0 0 1 1 1 1 N-terminal of Par3 and HAL proteins zf-C3HC4 PF00097.25 VDK67878.1 - 0.00074 19.3 2.7 0.00074 19.3 2.7 2.5 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK67878.1 - 0.03 14.4 3.4 0.097 12.7 3.4 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 VDK67878.1 - 7.3 6.6 15.0 0.21 11.6 8.0 2.0 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 VDK67878.1 - 7.7 6.4 13.3 0.11 12.3 5.0 2.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) CBS PF00571.28 VDK67880.1 - 1.1e-28 99.5 1.4 1.5e-11 44.6 0.6 4.6 4 0 0 4 4 4 4 CBS domain WW PF00397.26 VDK67880.1 - 1.3e-19 70.0 11.3 1.7e-09 37.6 3.3 2.8 2 0 0 2 2 2 2 WW domain FF PF01846.19 VDK67880.1 - 2.6e-12 46.7 1.4 8.5e-12 45.1 1.4 2.0 1 0 0 1 1 1 1 FF domain Glyco_hyd_101C PF17451.2 VDK67880.1 - 0.25 11.6 1.5 15 5.9 0.3 2.7 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain MRP-S23 PF10484.9 VDK67881.1 - 3.1e-28 98.6 0.1 3.9e-28 98.3 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S23 MRP-S25 PF13741.6 VDK67881.1 - 0.0022 17.6 1.3 0.03 13.9 0.0 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 FF PF01846.19 VDK67882.1 - 5.8e-30 103.2 14.0 2.5e-08 34.0 0.0 5.6 6 0 0 6 6 6 4 FF domain HD_6 PF18019.1 VDK67882.1 - 0.001 19.3 4.6 0.0013 18.8 2.0 2.3 2 0 0 2 2 2 1 HD domain OST_P2 PF18235.1 VDK67882.1 - 0.024 14.6 0.1 0.33 10.9 0.0 2.4 2 0 0 2 2 2 0 Oligosaccharyltransferase Peripheral 2 domain MID_MedPIWI PF18296.1 VDK67882.1 - 1.2 8.8 7.9 2.9 7.6 7.9 1.6 1 0 0 1 1 1 0 MID domain of medPIWI TRAPP PF04051.16 VDK67884.1 - 1.5e-30 105.9 0.1 1.8e-30 105.6 0.1 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component APS_kinase PF01583.20 VDK67884.1 - 0.05 13.5 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 Adenylylsulphate kinase RPN6_N PF18055.1 VDK67885.1 - 2.6e-29 101.9 3.4 4.8e-29 101.1 0.3 2.3 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 VDK67885.1 - 1.6e-15 57.5 2.2 3.6e-15 56.4 0.0 2.7 3 1 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 VDK67885.1 - 1.5e-10 40.6 0.8 3.1e-10 39.6 0.8 1.6 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 VDK67885.1 - 0.0005 20.3 6.6 0.032 14.5 2.2 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK67885.1 - 0.11 13.0 7.3 7.6 7.1 1.1 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 VDK67885.1 - 0.13 13.0 0.5 0.13 13.0 0.5 2.7 3 1 0 3 3 3 0 Tetratricopeptide repeat EF-G-binding_N PF07299.11 VDK67885.1 - 0.17 12.5 1.5 14 6.3 0.1 3.1 3 0 0 3 3 3 0 Elongation factor G-binding protein, N-terminal CENP-K PF11802.8 VDK67885.1 - 0.17 11.4 4.5 0.37 10.3 4.5 1.6 1 0 0 1 1 1 0 Centromere-associated protein K TPR_6 PF13174.6 VDK67885.1 - 0.28 11.9 2.7 1.9e+02 3.0 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat MutS_III PF05192.18 VDK67885.1 - 2.5 8.3 7.8 14 5.8 7.8 2.2 1 1 0 1 1 1 0 MutS domain III TPR_14 PF13428.6 VDK67885.1 - 4.6 8.3 6.3 72 4.6 0.3 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat CNOT1_CAF1_bind PF16415.5 VDK67886.1 - 2e-79 266.1 7.0 4.1e-79 265.1 7.0 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 VDK67886.1 - 4.4e-60 202.1 0.2 1.2e-59 200.7 0.2 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 VDK67886.1 - 1.3e-44 151.7 2.0 4.3e-44 150.0 2.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 VDK67886.1 - 3.3e-28 98.7 0.2 1.7e-27 96.4 0.0 2.4 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF1778 PF08681.11 VDK67886.1 - 0.013 15.4 0.1 0.038 13.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) Not1 PF04054.15 VDK67887.1 - 2.1e-131 438.2 4.9 3.9e-131 437.3 4.9 1.5 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CO_dh PF02552.16 VDK67887.1 - 0.1 12.3 0.1 0.36 10.6 0.1 1.8 2 0 0 2 2 2 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit Ank_2 PF12796.7 VDK67889.1 - 1.3e-26 93.0 3.3 3.3e-10 40.4 0.2 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK67889.1 - 2.5e-22 78.9 8.3 5.5e-09 36.4 0.1 5.7 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK67889.1 - 1.7e-21 73.9 5.0 1.8e-05 24.7 0.0 6.4 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 VDK67889.1 - 5.1e-19 68.1 4.3 1.1e-06 28.8 0.1 5.5 2 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 VDK67889.1 - 4.9e-18 64.7 10.7 4.5e-05 23.7 0.0 6.1 6 0 0 6 6 6 5 Ankyrin repeat SAM_1 PF00536.30 VDK67889.1 - 0.19 12.2 0.5 0.39 11.2 0.0 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) HLH PF00010.26 VDK67891.1 - 4.4e-13 49.0 0.3 9.9e-13 47.8 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Egg_lysin PF01303.17 VDK67893.1 - 0.053 13.7 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Egg lysin (Sperm-lysin) tRNA-synt_2 PF00152.20 VDK67894.1 - 6.9e-76 255.3 0.0 1.1e-75 254.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 VDK67894.1 - 1.8e-08 34.2 1.3 4.3e-08 33.0 1.3 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 VDK67894.1 - 0.0058 16.1 0.2 3.5 7.0 0.1 2.5 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) AAA_lid_3 PF17862.1 VDK67896.1 - 0.084 12.7 1.3 3.6 7.5 0.0 2.8 3 0 0 3 3 3 0 AAA+ lid domain Ribosomal_S2 PF00318.20 VDK67897.1 - 6.3e-27 94.2 0.0 1.8e-13 50.2 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 VDK67897.1 - 0.032 15.6 11.6 0.096 14.1 11.6 1.9 1 1 0 1 1 1 0 40S ribosomal protein SA C-terminus PP2C PF00481.21 VDK67898.1 - 3.5e-81 272.6 0.0 5.9e-81 271.9 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 VDK67898.1 - 1.8e-07 31.0 0.0 4.2e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C RPN7 PF10602.9 VDK67900.1 - 1.6e-56 190.8 0.4 3.3e-56 189.7 0.4 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 VDK67900.1 - 1.7e-16 60.7 0.1 6.9e-16 58.7 0.0 2.1 2 0 0 2 2 2 1 PCI domain DUF3199 PF11436.8 VDK67900.1 - 0.1 12.6 0.1 0.48 10.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3199) HTH_11 PF08279.12 VDK67900.1 - 0.1 12.5 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 HTH domain CelTOS PF18659.1 VDK67900.1 - 0.54 10.7 3.9 2.5 8.5 0.5 2.5 1 1 1 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites EssA PF10661.9 VDK67903.1 - 0.0074 16.1 3.7 0.017 14.9 3.7 1.6 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein EssA SPK PF04435.18 VDK67903.1 - 0.013 15.9 0.5 0.037 14.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF545) Myb_DNA-bind_2 PF08914.11 VDK67903.1 - 0.031 14.4 0.4 0.07 13.3 0.4 1.6 1 0 0 1 1 1 0 Rap1 Myb domain UPF0016 PF01169.19 VDK67904.1 - 3.3e-43 145.9 22.6 3e-22 78.7 6.5 2.6 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF3112 PF11309.8 VDK67904.1 - 0.073 12.5 0.1 0.073 12.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3112) Pkinase PF00069.25 VDK67905.1 - 7.9e-51 172.9 0.0 1.2e-50 172.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK67905.1 - 3.4e-26 92.1 0.0 5.2e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Metallophos PF00149.28 VDK67906.1 - 2.2e-38 132.8 0.0 2.9e-38 132.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK67906.1 - 0.0012 19.2 0.3 0.0023 18.3 0.3 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Motile_Sperm PF00635.26 VDK67907.1 - 6e-07 29.3 0.0 1.3e-05 25.0 0.0 2.1 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Lentivirus_VIF PF05851.11 VDK67907.1 - 0.0033 16.4 0.6 0.057 12.3 0.2 2.0 1 1 1 2 2 2 2 Lentivirus virion infectivity factor (VIF) Methyltrn_RNA_3 PF02598.17 VDK67908.1 - 4.6e-93 311.8 0.0 5.5e-93 311.6 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase SpoU_methylase PF00588.19 VDK67908.1 - 0.012 15.8 0.0 3.5 7.8 0.0 2.4 2 0 0 2 2 2 0 SpoU rRNA Methylase family PS_Dcarbxylase PF02666.15 VDK67909.1 - 4.2e-55 186.4 0.0 5e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase tRNA-synt_2b PF00587.25 VDK67910.1 - 1.5e-39 135.8 0.0 2.6e-39 135.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 VDK67910.1 - 7.1e-11 42.3 0.4 7.1e-11 42.3 0.4 2.7 3 0 0 3 3 3 2 Seryl-tRNA synthetase N-terminal domain DUF2457 PF10446.9 VDK67910.1 - 0.13 11.4 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ntox50 PF15542.6 VDK67910.1 - 0.27 12.0 2.5 0.89 10.4 2.5 1.8 1 0 0 1 1 1 0 Bacterial toxin 50 UDPGP PF01704.18 VDK67912.1 - 8.2e-189 627.5 2.0 9.5e-189 627.3 2.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase zf-C2H2_2 PF12756.7 VDK67914.1 - 1e-30 106.0 21.5 3.3e-25 88.3 2.8 3.7 3 1 1 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 VDK67914.1 - 3.8e-06 27.0 5.8 3.8e-06 27.0 5.8 4.3 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK67914.1 - 0.0001 22.6 4.8 0.0001 22.6 4.8 3.4 3 1 0 3 3 3 1 Zinc-finger of C2H2 type Jas PF16135.5 VDK67914.1 - 0.017 15.3 7.2 0.018 15.2 0.4 3.0 3 0 0 3 3 3 0 TPL-binding domain in jasmonate signalling zf-C2H2_4 PF13894.6 VDK67914.1 - 2.1 9.4 21.3 0.6 11.1 1.1 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger XPG_I PF00867.18 VDK67915.1 - 8.7e-18 64.5 0.2 2.2e-17 63.2 0.2 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 VDK67915.1 - 6.5e-16 58.7 0.0 1.4e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain TPR_2 PF07719.17 VDK67915.1 - 0.019 15.1 0.0 0.049 13.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat XPG_I_2 PF12813.7 VDK67915.1 - 0.061 12.8 0.1 0.1 12.0 0.1 1.3 1 0 0 1 1 1 0 XPG domain containing TPR_1 PF00515.28 VDK67915.1 - 0.093 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1794 PF08768.11 VDK67916.1 - 4.9e-06 26.5 0.0 5.7e-06 26.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) Cadherin PF00028.17 VDK67917.1 - 5.7e-29 100.4 0.1 9.3e-12 45.2 0.0 4.2 4 1 0 4 4 4 3 Cadherin domain 7tm_1 PF00001.21 VDK67952.1 - 5.5e-12 45.6 12.5 9.4e-12 44.8 12.2 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK67952.1 - 1.2e-06 28.2 9.9 4.5e-06 26.2 9.9 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Pkinase PF00069.25 VDK67953.1 - 3.6e-55 187.2 0.0 7.1e-54 182.9 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK67953.1 - 5e-27 94.8 0.0 2.6e-25 89.2 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK67953.1 - 0.025 14.5 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 VDK67953.1 - 0.034 13.8 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 VDK67953.1 - 0.061 12.3 0.2 0.16 10.9 0.2 1.7 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 VDK67953.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK67953.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.5 1 1 0 1 1 1 0 Kinase-like DEC1 PF15859.5 VDK67953.1 - 0.17 11.9 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Deleted in esophageal cancer 1 family EMP24_GP25L PF01105.24 VDK67954.1 - 1.9e-27 96.4 0.2 2.2e-27 96.2 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DP PF08781.10 VDK67954.1 - 0.035 14.0 0.3 0.068 13.1 0.3 1.6 1 1 0 1 1 1 0 Transcription factor DP EMP24_GP25L PF01105.24 VDK67956.1 - 3.6e-34 118.3 3.3 4.8e-34 117.9 3.3 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GOLD_2 PF13897.6 VDK67956.1 - 0.057 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Scramblase PF03803.15 VDK67956.1 - 0.11 11.8 2.1 0.21 10.9 0.8 1.9 1 1 1 2 2 2 0 Scramblase RPEL PF02755.15 VDK67957.1 - 5.2e-10 38.7 3.2 0.00019 21.0 0.1 2.7 2 0 0 2 2 2 2 RPEL repeat SAP PF02037.27 VDK67957.1 - 1.1e-08 34.6 0.7 3.3e-08 33.1 0.1 2.2 2 0 0 2 2 2 1 SAP domain CENP-W PF15510.6 VDK67957.1 - 0.25 11.6 6.3 12 6.2 1.7 3.7 3 1 0 3 3 3 0 CENP-W protein zf-H2C2_5 PF13909.6 VDK67959.1 - 0.00046 19.9 1.5 0.00046 19.9 1.5 5.5 6 0 0 6 6 6 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 VDK67959.1 - 0.004 17.9 36.6 0.78 10.7 1.2 7.2 7 0 0 7 7 7 4 C2H2-type zinc finger zf-Di19 PF05605.12 VDK67959.1 - 0.0076 16.5 3.8 0.0076 16.5 3.8 4.7 4 1 0 4 4 4 1 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 VDK67959.1 - 0.093 12.3 0.1 0.093 12.3 0.1 4.5 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger PAP1 PF08601.10 VDK67959.1 - 0.13 11.9 7.0 0.057 13.1 1.8 2.2 2 0 0 2 2 2 0 Transcription factor PAP1 zf-C2H2_2 PF12756.7 VDK67959.1 - 0.14 12.5 36.9 0.58 10.5 8.3 5.4 3 3 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-WRNIP1_ubi PF18279.1 VDK67959.1 - 0.29 11.9 0.1 0.29 11.9 0.1 3.5 4 0 0 4 4 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-H2C2_2 PF13465.6 VDK67959.1 - 0.74 10.3 32.8 0.5 10.9 1.0 5.8 6 0 0 6 6 6 0 Zinc-finger double domain Actin_micro PF17003.5 VDK67959.1 - 0.95 8.6 18.1 3.6 6.7 1.8 3.8 2 1 0 3 3 3 0 Putative actin-like family zf-C2H2 PF00096.26 VDK67959.1 - 1.4 9.5 36.9 0.38 11.3 1.0 6.8 7 0 0 7 7 7 0 Zinc finger, C2H2 type Med27 PF11571.8 VDK67959.1 - 4.4 7.7 12.4 1.9 8.9 1.1 3.4 2 1 1 3 3 3 0 Mediator complex subunit 27 NDUFB10 PF10249.9 VDK67961.1 - 3.7e-49 166.4 0.3 6.1e-49 165.7 0.3 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 LEDGF PF11467.8 VDK67961.1 - 0.46 10.1 2.3 4 7.1 0.8 2.2 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) PFK PF00365.20 VDK67962.1 - 5.8e-198 655.8 3.2 2.3e-109 365.1 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase DB PF01682.19 VDK67963.1 - 2.7e-18 66.1 0.9 2.7e-18 66.1 0.9 1.5 2 0 0 2 2 2 1 DB module Ribophorin_I PF04597.14 VDK67964.1 - 1.6e-129 433.0 4.9 2.1e-129 432.6 4.9 1.1 1 0 0 1 1 1 1 Ribophorin I DNA_repr_REX1B PF14966.6 VDK67964.1 - 3.9e-05 24.2 1.3 0.00039 21.0 0.1 2.5 2 0 0 2 2 2 1 DNA repair REX1-B Baculo_PEP_C PF04513.12 VDK67964.1 - 0.046 13.8 0.9 0.092 12.8 0.9 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.11 VDK67964.1 - 0.053 13.6 2.9 0.11 12.6 2.9 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) MHB PF16525.5 VDK67964.1 - 0.062 13.6 0.1 1.7 8.9 0.0 2.5 2 0 0 2 2 2 0 Haemophore, haem-binding CdvA PF18822.1 VDK67964.1 - 0.35 10.7 4.7 7.3 6.4 0.8 2.4 2 0 0 2 2 2 0 CdvA-like coiled-coil domain FAM184 PF15665.5 VDK67964.1 - 0.5 10.1 10.5 0.034 13.9 5.1 1.9 3 0 0 3 3 3 0 Family with sequence similarity 184, A and B DUF1664 PF07889.12 VDK67964.1 - 4.7 7.3 6.9 3 7.9 2.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Use1 PF09753.9 VDK67965.1 - 0.014 15.2 0.0 0.015 15.0 0.0 1.0 1 0 0 1 1 1 0 Membrane fusion protein Use1 APG17 PF04108.12 VDK67965.1 - 0.1 11.7 0.0 0.12 11.5 0.0 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 TIP39 PF14980.6 VDK67965.1 - 0.11 12.5 0.0 0.2 11.5 0.0 1.5 1 1 0 1 1 1 0 TIP39 peptide IMPDH PF00478.25 VDK67967.1 - 4.9e-127 423.7 3.0 5.9e-127 423.4 3.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 VDK67967.1 - 2.2e-12 47.2 1.8 0.00032 21.1 0.0 4.1 4 0 0 4 4 4 2 CBS domain FMN_dh PF01070.18 VDK67967.1 - 1.4e-10 40.7 1.7 5.1e-10 38.9 1.2 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 VDK67967.1 - 4.6e-10 39.4 13.4 9.8e-06 25.2 7.4 3.2 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 VDK67967.1 - 4.8e-05 22.9 3.5 0.00081 18.9 0.4 2.4 1 1 1 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 VDK67967.1 - 0.0036 16.5 0.8 0.008 15.4 0.8 1.6 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase Dus PF01207.17 VDK67967.1 - 0.0036 16.4 2.6 0.3 10.1 0.1 2.2 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) ThiG PF05690.14 VDK67967.1 - 0.012 14.9 4.4 0.083 12.2 1.0 2.2 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG SPOR PF05036.13 VDK67967.1 - 0.013 15.9 0.1 0.034 14.5 0.1 1.7 1 0 0 1 1 1 0 Sporulation related domain Response_reg PF00072.24 VDK67967.1 - 0.035 14.3 0.2 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Response regulator receiver domain PcrB PF01884.17 VDK67967.1 - 0.078 12.4 9.3 2.7 7.4 0.1 4.0 2 1 2 4 4 4 0 PcrB family G3P_antiterm PF04309.12 VDK67967.1 - 0.13 11.6 1.5 4.8 6.6 0.1 2.6 2 1 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator PseudoU_synth_1 PF01416.20 VDK67968.1 - 1.1e-13 51.6 0.0 2.2e-11 44.2 0.0 2.4 2 1 0 2 2 2 2 tRNA pseudouridine synthase TrbM PF07424.11 VDK67968.1 - 0.18 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 TrbM RRM_1 PF00076.22 VDK67969.1 - 2.5e-38 129.7 0.2 1.7e-19 69.4 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK67969.1 - 2.6e-19 69.1 0.3 4.1e-10 39.7 0.0 2.4 1 1 1 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 VDK67969.1 - 2.3e-08 33.9 0.3 6.2e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 VDK67969.1 - 0.00068 19.6 0.9 0.11 12.6 0.2 2.3 1 1 1 2 2 2 2 RNA binding motif RL PF17797.1 VDK67969.1 - 0.0056 16.6 0.0 0.23 11.4 0.0 2.3 2 0 0 2 2 2 1 RL domain RRM_8 PF11835.8 VDK67969.1 - 0.085 13.1 0.0 0.27 11.5 0.0 1.8 2 0 0 2 2 2 0 RRM-like domain LSM PF01423.22 VDK67970.1 - 7e-17 60.9 0.3 1.3e-16 60.0 0.3 1.5 1 0 0 1 1 1 1 LSM domain BLOC1_2 PF10046.9 VDK67971.1 - 2e-31 108.2 4.8 2.5e-31 107.8 4.8 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 THOC7 PF05615.13 VDK67971.1 - 0.0013 19.0 2.2 0.0016 18.7 2.2 1.2 1 0 0 1 1 1 1 Tho complex subunit 7 DUF1664 PF07889.12 VDK67971.1 - 0.0025 17.9 1.5 0.015 15.3 1.0 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) DUF724 PF05266.14 VDK67971.1 - 0.006 16.4 0.8 0.007 16.2 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Laminin_II PF06009.12 VDK67971.1 - 0.009 16.0 2.1 0.024 14.7 1.4 1.8 1 1 1 2 2 2 2 Laminin Domain II DUF2330 PF10092.9 VDK67971.1 - 0.013 14.6 0.6 0.016 14.3 0.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2330) WXG100 PF06013.12 VDK67971.1 - 0.016 15.4 4.5 0.66 10.2 1.2 2.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Phage_GPO PF05929.11 VDK67971.1 - 0.028 14.1 1.8 0.047 13.3 1.9 1.4 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF948 PF06103.11 VDK67971.1 - 0.031 14.5 2.3 0.24 11.7 0.5 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 VDK67971.1 - 0.036 14.5 2.2 0.42 11.1 0.4 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Phospholip_B PF04916.13 VDK67971.1 - 0.037 12.6 0.6 0.043 12.4 0.6 1.0 1 0 0 1 1 1 0 Phospholipase B Nup54 PF13874.6 VDK67971.1 - 0.037 14.1 1.6 0.047 13.8 1.6 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Sec34 PF04136.15 VDK67971.1 - 0.045 13.6 1.8 0.11 12.3 1.8 1.8 1 1 0 1 1 1 0 Sec34-like family DUF1759 PF03564.15 VDK67971.1 - 0.048 13.6 1.7 0.089 12.7 1.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1759) Exonuc_VII_L PF02601.15 VDK67971.1 - 0.06 12.9 1.0 0.074 12.6 1.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit IFT57 PF10498.9 VDK67971.1 - 0.065 12.2 4.5 0.19 10.7 3.2 1.9 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DASH_Dad2 PF08654.10 VDK67971.1 - 0.067 13.6 0.8 4.6 7.7 0.4 2.8 1 1 2 3 3 3 0 DASH complex subunit Dad2 ParB PF08775.10 VDK67971.1 - 0.076 13.5 1.5 0.22 12.0 1.4 1.8 1 1 0 1 1 1 0 ParB family Spc7 PF08317.11 VDK67971.1 - 0.083 11.8 3.8 0.16 10.8 3.8 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Prominin PF05478.11 VDK67971.1 - 0.092 10.7 0.7 0.1 10.5 0.7 1.1 1 0 0 1 1 1 0 Prominin AAA_assoc PF14363.6 VDK67971.1 - 0.13 12.6 0.5 0.64 10.4 0.0 2.0 1 1 1 2 2 2 0 Domain associated at C-terminal with AAA Med9 PF07544.13 VDK67971.1 - 0.17 12.0 1.3 0.37 10.9 1.3 1.6 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 JIP_LZII PF16471.5 VDK67971.1 - 0.2 11.8 2.4 9.2 6.5 0.4 2.4 1 1 0 2 2 2 0 JNK-interacting protein leucine zipper II UPF0449 PF15136.6 VDK67971.1 - 0.26 11.8 4.7 2.9 8.4 2.4 2.2 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Baculo_PEP_C PF04513.12 VDK67971.1 - 0.27 11.3 2.0 0.48 10.5 1.4 1.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.13 VDK67971.1 - 0.27 10.4 1.5 0.35 10.1 1.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein ZapA PF05164.13 VDK67971.1 - 0.55 10.7 3.8 3.5 8.1 0.2 2.6 1 1 1 2 2 2 0 Cell division protein ZapA Nore1-SARAH PF16517.5 VDK67971.1 - 1.3 9.0 4.6 6.1 6.8 0.1 3.3 3 1 0 3 3 3 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Homeodomain PF00046.29 VDK67973.1 - 1.5e-21 76.0 5.1 2.4e-21 75.3 5.1 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK67973.1 - 0.0006 19.7 0.6 0.0012 18.7 0.6 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 VDK67973.1 - 0.0053 16.2 0.4 0.011 15.1 0.4 1.5 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez YdaS_antitoxin PF15943.5 VDK67973.1 - 0.039 13.8 0.1 0.07 13.0 0.1 1.3 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Enkurin PF13864.6 VDK67973.1 - 0.15 12.5 2.6 0.24 11.9 2.6 1.3 1 0 0 1 1 1 0 Calmodulin-binding DUF4552 PF15089.6 VDK67973.1 - 0.17 10.9 1.0 0.23 10.5 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) CNP1 PF08750.11 VDK67973.1 - 0.18 11.8 2.4 0.6 10.1 0.2 2.4 3 0 0 3 3 3 0 CNP1-like family Carn_acyltransf PF00755.20 VDK67975.1 - 7.1e-156 520.2 0.0 8.3e-156 520.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Defensin_2 PF01097.18 VDK67975.1 - 0.076 13.0 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Arthropod defensin MFS_1 PF07690.16 VDK67976.1 - 4e-31 108.2 40.8 9.5e-30 103.7 32.0 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily Alpha-amylase_C PF02806.18 VDK67976.1 - 0.12 12.8 0.1 0.26 11.8 0.1 1.5 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain RA PF00788.23 VDK67977.1 - 1.3e-17 64.2 0.2 3.3e-17 62.9 0.2 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Nore1-SARAH PF16517.5 VDK67977.1 - 1.3e-14 53.8 2.8 3.3e-14 52.5 2.8 1.7 1 0 0 1 1 1 1 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain C1_1 PF00130.22 VDK67977.1 - 7.5e-13 48.2 8.2 1.4e-12 47.3 8.2 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 VDK67977.1 - 0.45 10.5 7.3 1.1 9.2 7.3 1.7 1 0 0 1 1 1 0 PHD-finger Metallophos PF00149.28 VDK67978.1 - 1.8e-38 133.1 0.0 3e-38 132.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 VDK67978.1 - 0.0023 17.3 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5378) DUF1647 PF07801.11 VDK67978.1 - 0.079 12.7 0.6 2.3 8.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Pkinase PF00069.25 VDK67979.1 - 1.6e-60 204.8 0.1 4.2e-60 203.4 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK67979.1 - 1.2e-38 132.9 0.1 9e-38 130.0 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 VDK67979.1 - 2.1e-15 56.8 0.0 8.6e-15 54.8 0.0 2.1 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 VDK67979.1 - 8.3e-08 31.9 0.0 3.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 VDK67979.1 - 0.00052 18.9 0.1 0.0016 17.3 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase DSHCT PF08148.12 VDK67979.1 - 0.13 12.0 0.1 0.33 10.6 0.1 1.8 1 1 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.23 VDK67979.1 - 0.18 11.7 0.0 1.8 8.4 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family V_ATPase_I PF01496.19 VDK67980.1 - 7e-295 980.2 3.2 7.9e-295 980.0 3.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Med9 PF07544.13 VDK67980.1 - 0.15 12.2 0.2 0.44 10.7 0.2 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Peptidase_M24 PF00557.24 VDK67982.1 - 2.3e-50 171.2 0.3 2.9e-50 170.9 0.3 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 VDK67982.1 - 1.2e-17 63.9 7.9 2.7e-17 62.8 7.9 1.6 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 VDK67982.1 - 0.00033 20.7 5.0 0.00087 19.3 5.0 1.7 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 VDK67982.1 - 0.013 15.3 6.5 0.032 14.1 6.5 1.7 1 0 0 1 1 1 0 HIT zinc finger FYVE PF01363.21 VDK67983.1 - 1.2e-14 54.2 4.6 2.7e-14 53.0 4.6 1.7 1 0 0 1 1 1 1 FYVE zinc finger RhoGEF PF00621.20 VDK67983.1 - 4.7e-10 40.0 2.7 4.7e-10 40.0 2.7 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 VDK67983.1 - 1.2e-08 35.4 0.2 3.3e-08 34.0 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 VDK67983.1 - 1.3e-06 28.3 2.1 3.7e-06 26.8 1.3 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 VDK67983.1 - 1.4e-05 25.1 2.1 1.7e-05 24.8 0.7 1.8 2 0 0 2 2 2 1 PH domain PH_4 PF15404.6 VDK67983.1 - 0.0013 18.6 0.0 0.0033 17.3 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 VDK67983.1 - 0.02 15.2 0.2 0.063 13.6 0.2 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain EF-hand_2 PF09068.11 VDK67983.1 - 0.078 13.1 0.7 0.18 11.9 0.7 1.9 1 1 0 1 1 1 0 EF hand zf-RING_4 PF14570.6 VDK67983.1 - 0.17 11.7 7.7 0.13 12.1 5.4 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 VDK67983.1 - 1.6 8.9 5.5 0.74 10.0 2.8 1.8 2 0 0 2 2 2 0 Zinc-binding RING-finger IBR PF01485.21 VDK67983.1 - 2.1 8.6 7.6 0.37 11.1 3.3 2.0 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain SPA PF08616.10 VDK67985.1 - 3.5e-11 43.1 0.2 9.1e-11 41.7 0.2 1.7 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 VDK67985.1 - 3.8e-07 29.2 0.3 1.3e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Transport protein Avl9 DENN PF02141.21 VDK67985.1 - 0.00027 20.9 1.2 0.0071 16.3 1.2 2.5 1 1 0 1 1 1 1 DENN (AEX-3) domain TGF_beta PF00019.20 VDK67991.1 - 1.9e-30 105.9 0.5 4.2e-30 104.8 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 VDK67991.1 - 0.071 12.8 3.7 0.12 12.1 0.2 2.5 2 1 0 3 3 3 0 TGF-beta propeptide TGF_beta PF00019.20 VDK67993.1 - 1.9e-30 105.9 0.5 4.2e-30 104.8 0.5 1.6 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 VDK67993.1 - 0.071 12.8 3.7 0.12 12.1 0.2 2.5 2 1 0 3 3 3 0 TGF-beta propeptide SPA PF08616.10 VDK67996.1 - 3.5e-11 43.1 0.2 9.1e-11 41.7 0.2 1.7 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 VDK67996.1 - 3.8e-07 29.2 0.3 1.3e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Transport protein Avl9 DENN PF02141.21 VDK67996.1 - 0.00027 20.9 1.2 0.0071 16.3 1.2 2.5 1 1 0 1 1 1 1 DENN (AEX-3) domain FYVE PF01363.21 VDK67997.1 - 1.2e-14 54.2 4.6 2.7e-14 53.0 4.6 1.7 1 0 0 1 1 1 1 FYVE zinc finger RhoGEF PF00621.20 VDK67997.1 - 4.7e-10 40.0 2.7 4.7e-10 40.0 2.7 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 VDK67997.1 - 1.2e-08 35.4 0.2 3.3e-08 34.0 0.2 1.8 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 VDK67997.1 - 1.3e-06 28.3 2.1 3.7e-06 26.8 1.3 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 VDK67997.1 - 1.4e-05 25.1 2.1 1.7e-05 24.8 0.7 1.8 2 0 0 2 2 2 1 PH domain PH_4 PF15404.6 VDK67997.1 - 0.0013 18.6 0.0 0.0033 17.3 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 VDK67997.1 - 0.02 15.2 0.2 0.063 13.6 0.2 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain EF-hand_2 PF09068.11 VDK67997.1 - 0.078 13.1 0.7 0.18 11.9 0.7 1.9 1 1 0 1 1 1 0 EF hand zf-RING_4 PF14570.6 VDK67997.1 - 0.17 11.7 7.7 0.13 12.1 5.4 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 VDK67997.1 - 1.6 8.9 5.5 0.74 10.0 2.8 1.8 2 0 0 2 2 2 0 Zinc-binding RING-finger IBR PF01485.21 VDK67997.1 - 2.1 8.6 7.6 0.37 11.1 3.3 2.0 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Peptidase_M24 PF00557.24 VDK67998.1 - 1.9e-50 171.5 0.3 2.3e-50 171.2 0.3 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 VDK67998.1 - 1e-17 64.1 7.9 2.4e-17 62.9 7.9 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 VDK67998.1 - 0.00028 20.9 5.0 0.00078 19.5 5.0 1.7 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 VDK67998.1 - 0.011 15.6 6.5 0.029 14.3 6.5 1.8 1 0 0 1 1 1 0 HIT zinc finger V_ATPase_I PF01496.19 VDK67999.1 - 7e-295 980.2 3.2 7.9e-295 980.0 3.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Med9 PF07544.13 VDK67999.1 - 0.15 12.2 0.2 0.44 10.7 0.2 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Pkinase PF00069.25 VDK68001.1 - 1.6e-60 204.8 0.1 4.2e-60 203.4 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK68001.1 - 1.2e-38 132.9 0.1 9e-38 130.0 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 VDK68001.1 - 2.1e-15 56.8 0.0 8.6e-15 54.8 0.0 2.1 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 VDK68001.1 - 8.3e-08 31.9 0.0 3.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 VDK68001.1 - 0.00052 18.9 0.1 0.0016 17.3 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase DSHCT PF08148.12 VDK68001.1 - 0.13 12.0 0.1 0.33 10.6 0.1 1.8 1 1 0 1 1 1 0 DSHCT (NUC185) domain APH PF01636.23 VDK68001.1 - 0.18 11.7 0.0 1.8 8.4 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Reg_prop PF07494.11 VDK68037.1 - 0.31 11.4 1.7 3 8.4 0.1 3.1 3 0 0 3 3 3 0 Two component regulator propeller RhoGEF PF00621.20 VDK68038.1 - 3.2e-38 131.8 4.2 3.2e-38 131.8 4.2 2.3 3 0 0 3 3 3 1 RhoGEF domain LRR_8 PF13855.6 VDK68039.1 - 1.3e-13 50.5 20.2 0.00021 21.0 4.3 4.3 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 VDK68039.1 - 9.4e-12 45.0 25.5 3.8e-05 23.9 1.5 6.0 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) ig PF00047.25 VDK68039.1 - 0.044 14.0 0.0 0.096 12.9 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Apolipoprotein PF01442.18 VDK68039.1 - 0.12 12.3 3.3 0.21 11.5 3.3 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain LRR_1 PF00560.33 VDK68039.1 - 0.33 11.7 29.5 3.8 8.4 0.5 8.1 5 2 3 8 8 8 0 Leucine Rich Repeat Exonuc_VII_L PF02601.15 VDK68039.1 - 1.5 8.4 7.7 2.3 7.7 7.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ribosomal_S18 PF01084.20 VDK68040.1 - 2.8e-14 53.1 0.0 4.8e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 Homeodomain PF00046.29 VDK68042.1 - 7.1e-20 70.6 2.8 1.4e-19 69.7 2.8 1.4 1 0 0 1 1 1 1 Homeodomain QLQ PF08880.11 VDK68042.1 - 0.004 16.9 0.3 0.007 16.1 0.3 1.4 1 0 0 1 1 1 1 QLQ Homeobox_KN PF05920.11 VDK68042.1 - 0.0072 16.2 0.2 0.018 15.0 0.2 1.7 1 1 0 1 1 1 1 Homeobox KN domain CENP-F_N PF10481.9 VDK68042.1 - 0.0089 15.7 0.2 0.012 15.2 0.2 1.3 1 0 0 1 1 1 1 Cenp-F N-terminal domain MerR_1 PF13411.6 VDK68042.1 - 0.11 12.6 0.2 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 MerR HTH family regulatory protein RRM_1 PF00076.22 VDK68043.1 - 6.3e-15 54.8 0.0 1.5e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK68043.1 - 0.00021 20.9 0.0 0.00041 19.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SOAR PF16533.5 VDK68045.1 - 1e-32 112.1 5.1 1.8e-32 111.3 0.0 2.8 2 1 0 2 2 2 1 STIM1 Orai1-activating region SAM_2 PF07647.17 VDK68045.1 - 3.6e-08 33.4 0.0 7.1e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 VDK68045.1 - 7.8e-08 32.6 0.0 1.7e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Allexi_40kDa PF05549.11 VDK68045.1 - 0.18 11.3 1.6 5.9 6.3 0.4 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein 60KD_IMP PF02096.20 VDK68045.1 - 0.49 10.3 3.9 0.3 11.0 1.5 1.9 2 0 0 2 2 2 0 60Kd inner membrane protein Seryl_tRNA_N PF02403.22 VDK68045.1 - 0.72 10.1 8.2 1.1 9.5 0.2 2.8 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.14 VDK68045.1 - 0.75 9.6 10.1 5.7 6.7 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) AF-4 PF05110.13 VDK68048.1 - 1.8e-12 46.3 37.5 2.5e-10 39.2 14.8 3.4 3 1 1 4 4 4 3 AF-4 proto-oncoprotein AvrM-A PF18241.1 VDK68048.1 - 0.15 12.4 3.2 0.27 11.7 0.3 2.6 2 0 0 2 2 2 0 Flax-rust effector AvrM-A HMG_box PF00505.19 VDK68050.1 - 1.2e-29 102.5 7.2 2.1e-14 53.7 0.2 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK68050.1 - 2.3e-27 95.4 8.5 3.9e-17 62.6 2.7 2.3 2 0 0 2 2 2 2 HMG-box domain Ccdc124 PF06244.12 VDK68050.1 - 0.012 16.2 3.3 0.019 15.5 3.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 124 /Oxs1 DUF1289 PF06945.13 VDK68050.1 - 0.25 11.2 1.2 1.1 9.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) GPCR_chapero_1 PF11904.8 VDK68052.1 - 1e-81 274.8 0.1 1.4e-81 274.3 0.1 1.2 1 0 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.7 VDK68052.1 - 7.2e-20 71.4 2.8 3.2e-10 40.4 0.3 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 VDK68052.1 - 1.9e-09 37.5 0.1 6.5e-06 26.4 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 VDK68052.1 - 8.8e-09 34.9 2.9 0.00078 19.7 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 VDK68052.1 - 1.2e-08 35.1 0.9 1.7e-07 31.4 0.1 2.7 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 VDK68052.1 - 1.5e-08 35.0 1.1 6e-05 23.5 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Rad60-SLD PF11976.8 VDK68054.1 - 3.7e-17 61.9 0.1 4.3e-17 61.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 VDK68054.1 - 3.5e-13 49.1 0.1 4.2e-13 48.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Filament PF00038.21 VDK68055.1 - 4.9e-65 220.1 50.3 4.5e-64 217.0 50.3 2.0 1 1 0 1 1 1 1 Intermediate filament protein DUF2353 PF09789.9 VDK68055.1 - 1.6e-05 24.4 15.4 1.6e-05 24.4 15.4 3.0 1 1 1 2 2 1 1 Uncharacterized coiled-coil protein (DUF2353) Myosin_tail_1 PF01576.19 VDK68055.1 - 3.6e-05 21.8 45.1 0.0032 15.4 20.4 2.6 1 1 1 2 2 2 2 Myosin tail APG6_N PF17675.1 VDK68055.1 - 6.9e-05 23.4 49.5 0.25 11.9 3.0 5.7 2 1 3 5 5 5 3 Apg6 coiled-coil region CENP-H PF05837.12 VDK68055.1 - 0.00077 19.8 3.9 0.00077 19.8 3.9 5.2 2 2 2 5 5 5 1 Centromere protein H (CENP-H) Spc7 PF08317.11 VDK68055.1 - 0.00089 18.2 41.8 0.023 13.6 11.7 3.2 1 1 1 3 3 3 2 Spc7 kinetochore protein GAS PF13851.6 VDK68055.1 - 0.0014 18.1 44.0 0.013 14.9 7.6 4.0 1 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 VDK68055.1 - 0.0017 18.4 38.7 0.011 15.8 0.7 5.1 2 2 3 5 5 5 2 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.11 VDK68055.1 - 0.0031 17.3 21.1 0.02 14.7 1.9 3.5 2 1 0 3 3 3 2 Bacillus haemolytic enterotoxin (HBL) Uso1_p115_C PF04871.13 VDK68055.1 - 0.0044 17.4 6.2 0.0044 17.4 6.2 4.3 1 1 1 2 2 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region SOGA PF11365.8 VDK68055.1 - 0.012 16.8 30.0 0.16 13.1 3.3 5.6 1 1 5 6 6 6 0 Protein SOGA Lzipper-MIP1 PF14389.6 VDK68055.1 - 0.02 15.2 6.8 0.02 15.2 6.8 3.8 4 1 1 5 5 3 0 Leucine-zipper of ternary complex factor MIP1 Lebercilin PF15619.6 VDK68055.1 - 0.021 14.5 43.7 0.068 12.8 20.4 2.8 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 VDK68055.1 - 0.022 15.0 43.9 0.16 12.1 17.6 3.6 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) MAD PF05557.13 VDK68055.1 - 0.1 11.0 45.7 0.32 9.3 30.4 2.8 1 1 1 2 2 2 0 Mitotic checkpoint protein YabA PF06156.13 VDK68055.1 - 0.11 13.2 33.5 3.4 8.4 0.7 5.9 1 1 3 5 5 5 0 Initiation control protein YabA DHR10 PF18595.1 VDK68055.1 - 0.29 11.2 47.4 0.17 11.9 3.8 5.5 2 1 3 5 5 5 0 Designed helical repeat protein 10 domain Fez1 PF06818.15 VDK68055.1 - 0.32 11.4 40.5 1.7 9.1 6.2 4.0 1 1 3 4 4 4 0 Fez1 DUF4407 PF14362.6 VDK68055.1 - 0.34 10.2 32.6 0.059 12.7 7.9 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.9 VDK68055.1 - 1.1 9.3 45.0 1.1 9.3 8.4 4.4 1 1 4 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UPF0242 PF06785.11 VDK68055.1 - 1.2 9.2 46.6 2.9 8.0 6.0 3.9 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Spc42p PF11544.8 VDK68055.1 - 2.3 8.3 16.8 0.049 13.6 1.7 4.3 4 0 0 4 4 4 0 Spindle pole body component Spc42p UPF0184 PF03670.13 VDK68055.1 - 3.3 8.2 10.7 1.7 9.0 0.3 3.7 2 2 1 3 3 3 0 Uncharacterised protein family (UPF0184) DUF3584 PF12128.8 VDK68055.1 - 4.2 4.8 42.6 0.86 7.0 5.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF4600 PF15372.6 VDK68055.1 - 5 7.6 30.7 0.66 10.4 3.2 3.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4600) DUF948 PF06103.11 VDK68055.1 - 5.2 7.4 11.1 2.6 8.4 0.5 4.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) TMF_DNA_bd PF12329.8 VDK68055.1 - 6.1 6.9 35.5 3.1 7.9 2.4 6.1 4 2 1 5 5 5 0 TATA element modulatory factor 1 DNA binding Golgin_A5 PF09787.9 VDK68055.1 - 8 5.8 45.7 0.13 11.7 9.3 4.1 1 1 2 4 4 4 0 Golgin subfamily A member 5 FlaC_arch PF05377.11 VDK68055.1 - 9.5 6.7 23.9 9.3 6.7 1.0 6.3 7 1 1 8 8 7 0 Flagella accessory protein C (FlaC) SET PF00856.28 VDK68059.1 - 8.3e-20 71.9 0.1 8.3e-20 71.9 0.1 4.5 4 2 0 4 4 4 1 SET domain N-SET PF11764.8 VDK68059.1 - 4.2e-11 43.3 0.4 4.2e-11 43.3 0.4 5.5 5 2 1 6 6 6 1 COMPASS (Complex proteins associated with Set1p) component N RRM_1 PF00076.22 VDK68059.1 - 1.2e-07 31.4 0.0 2.8e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK68059.1 - 0.03 14.2 0.0 0.082 12.8 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF1285 PF06938.11 VDK68059.1 - 0.095 12.7 0.9 0.22 11.5 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1285) TPR_2 PF07719.17 VDK68060.1 - 2.5e-19 67.7 19.7 2.8e-05 23.9 0.0 11.0 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_1 PF00515.28 VDK68060.1 - 4.4e-19 67.4 7.4 1e-05 25.1 0.0 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 VDK68060.1 - 5.7e-16 57.8 17.7 0.23 12.3 0.0 9.5 5 3 4 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.6 VDK68060.1 - 5e-13 49.5 5.3 0.052 14.2 0.0 7.3 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 VDK68060.1 - 4.6e-12 46.3 11.7 0.02 15.4 0.0 7.3 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 VDK68060.1 - 3.2e-11 42.5 11.9 0.001 19.1 0.0 9.2 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK68060.1 - 4.1e-11 42.5 12.4 0.0082 16.5 0.0 8.4 9 0 0 9 9 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK68060.1 - 3.1e-10 40.2 14.9 9.1e-05 22.6 0.0 5.4 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 VDK68060.1 - 4.9e-10 39.6 24.2 0.02 15.2 0.1 8.7 5 3 4 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 VDK68060.1 - 1.2e-09 37.6 10.2 0.0049 16.8 0.0 9.0 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK68060.1 - 5.7e-07 29.6 6.2 0.052 13.7 0.0 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK68060.1 - 0.00025 20.6 10.7 0.00062 19.4 0.0 5.2 6 0 0 6 6 6 1 TPR repeat TPR_10 PF13374.6 VDK68060.1 - 0.00077 19.2 14.2 0.35 10.8 0.1 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 VDK68060.1 - 0.67 9.5 6.1 16 5.1 0.1 4.0 4 0 0 4 4 4 0 SHNi-TPR TPR_6 PF13174.6 VDK68060.1 - 7.4 7.4 10.1 34 5.3 0.0 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat BTAD PF03704.17 VDK68060.1 - 8.1 6.9 10.6 3.8 7.9 0.1 4.5 5 1 1 6 6 6 0 Bacterial transcriptional activator domain Stork_head PF10264.9 VDK68061.1 - 0.088 13.0 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain PHB_depo_C PF06850.11 VDK68061.1 - 0.17 11.4 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 PHB de-polymerase C-terminus Methyltransf_11 PF08241.12 VDK68062.1 - 3.5e-16 59.6 0.0 1.8e-15 57.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK68062.1 - 1.6e-14 54.4 0.0 7.8e-14 52.2 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 VDK68062.1 - 3.4e-12 46.2 0.0 6.4e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 VDK68062.1 - 3.9e-12 46.2 0.1 1e-11 44.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 VDK68062.1 - 4.2e-09 36.1 0.0 9.4e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 VDK68062.1 - 6.4e-09 36.5 0.0 3.6e-08 34.0 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK68062.1 - 8.4e-09 35.5 0.0 1.6e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 VDK68062.1 - 0.0035 16.8 0.3 0.0088 15.5 0.2 1.7 2 0 0 2 2 2 1 Putative methyltransferase NodS PF05401.11 VDK68062.1 - 0.01 15.5 0.0 0.063 12.9 0.0 2.1 2 0 0 2 2 2 0 Nodulation protein S (NodS) Methyltransf_8 PF05148.15 VDK68062.1 - 0.04 13.7 1.2 0.17 11.7 0.0 2.5 3 0 0 3 3 3 0 Hypothetical methyltransferase RPA_C PF08784.11 VDK68062.1 - 0.085 13.5 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Replication protein A C terminal TehB PF03848.14 VDK68062.1 - 0.11 11.9 0.0 0.45 9.9 0.0 2.0 2 0 0 2 2 2 0 Tellurite resistance protein TehB TMEM43 PF07787.12 VDK68064.1 - 5.8 6.2 5.9 7.1 5.9 5.9 1.2 1 0 0 1 1 1 0 Transmembrane protein 43 ubiquitin PF00240.23 VDK68066.1 - 2.4e-09 36.8 0.0 3.9e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family CysG_dimeriser PF10414.9 VDK68066.1 - 0.011 15.4 0.1 0.029 14.1 0.1 1.6 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region EpsG PF14897.6 VDK68066.1 - 3.5 6.8 11.0 3 7.1 5.2 2.1 2 0 0 2 2 2 0 EpsG family EST1_DNA_bind PF10373.9 VDK68068.1 - 4.8e-29 101.7 0.3 1.9e-28 99.7 0.3 2.1 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain PIN_4 PF13638.6 VDK68068.1 - 3.1e-17 63.1 0.1 1.2e-16 61.1 0.1 2.1 1 0 0 1 1 1 1 PIN domain EST1 PF10374.9 VDK68068.1 - 1e-10 42.4 0.1 1e-10 42.4 0.1 3.4 5 0 0 5 5 5 1 Telomerase activating protein Est1 PDEase_I PF00233.19 VDK68074.1 - 3.9e-51 174.1 10.6 6e-51 173.5 10.6 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 VDK68074.1 - 5.8e-12 46.4 0.0 1.2e-11 45.4 0.0 1.6 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 VDK68074.1 - 0.00017 21.9 0.0 0.00055 20.2 0.0 1.8 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 VDK68074.1 - 0.034 14.5 0.0 0.09 13.1 0.0 1.8 1 0 0 1 1 1 0 GAF domain Pet191_N PF10203.9 VDK68075.1 - 4e-21 75.1 8.7 5e-21 74.8 8.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 VDK68075.1 - 0.074 13.1 7.2 1.5 8.9 0.2 2.6 1 1 2 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Phe_tRNA-synt_N PF02912.18 VDK68075.1 - 0.15 12.0 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain Chromo_shadow PF01393.19 VDK68076.1 - 2.4e-08 33.9 0.1 6e-08 32.7 0.1 1.7 1 0 0 1 1 1 1 Chromo shadow domain Tho1_MOS11_C PF18592.1 VDK68078.1 - 4.6e-15 55.2 18.7 1.3e-06 28.1 0.3 3.4 1 1 2 3 3 3 3 Tho1/MOS11 C-terminal domain SAP PF02037.27 VDK68078.1 - 2.9e-13 49.2 0.3 8.4e-13 47.7 0.3 1.9 1 0 0 1 1 1 1 SAP domain DUF815 PF05673.13 VDK68078.1 - 0.026 13.7 0.8 0.27 10.3 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF815) RWD PF05773.22 VDK68079.1 - 3.6e-11 43.4 1.3 1.2e-10 41.6 1.3 1.9 1 1 0 1 1 1 1 RWD domain zf-RING_UBOX PF13445.6 VDK68079.1 - 5.3e-05 23.1 2.9 0.00013 21.9 1.0 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 VDK68079.1 - 6.7e-05 23.1 10.5 0.00025 21.3 9.6 2.4 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 VDK68079.1 - 0.0068 16.2 8.1 0.19 11.6 7.9 2.9 1 1 2 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK68079.1 - 0.014 15.3 9.9 0.16 11.9 10.3 2.4 1 1 0 1 1 1 0 zinc-RING finger domain Trm112p PF03966.16 VDK68079.1 - 0.042 14.4 0.0 0.12 13.0 0.0 1.8 1 0 0 1 1 1 0 Trm112p-like protein Rad50_zn_hook PF04423.14 VDK68079.1 - 0.12 12.2 4.1 0.39 10.6 0.5 2.8 2 1 0 2 2 2 0 Rad50 zinc hook motif zf-C3HC4_3 PF13920.6 VDK68079.1 - 0.13 12.2 9.9 1.9 8.4 0.1 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK68079.1 - 0.2 11.6 9.6 0.32 10.9 5.5 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 VDK68079.1 - 0.22 11.3 8.3 0.12 12.2 5.5 2.1 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_1 PF14446.6 VDK68079.1 - 0.51 10.3 9.0 7.3 6.6 0.1 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.29 VDK68079.1 - 1.9 8.5 8.3 12 5.9 8.4 2.1 1 1 1 2 2 2 0 PHD-finger Ras PF00071.22 VDK68080.1 - 3.8e-54 182.7 0.2 4.7e-54 182.3 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK68080.1 - 7.7e-20 71.3 0.0 1.3e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK68080.1 - 2.3e-09 36.9 0.0 3.1e-09 36.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK68080.1 - 4.9e-06 26.6 0.2 0.0058 16.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 VDK68080.1 - 2.9e-05 23.7 0.0 0.00011 21.8 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 VDK68080.1 - 0.0013 18.2 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 VDK68080.1 - 0.027 14.3 0.8 0.074 12.8 0.0 1.8 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 VDK68080.1 - 0.079 13.0 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK68080.1 - 0.17 11.4 0.3 0.54 9.8 0.3 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_7 PF12775.7 VDK68080.1 - 0.18 11.3 0.1 1.2 8.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Lung_7-TM_R PF06814.13 VDK68081.1 - 1.3e-92 310.2 23.4 1.9e-92 309.7 23.4 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Spo7 PF03907.13 VDK68081.1 - 0.13 11.7 2.2 0.44 10.0 2.2 1.8 1 0 0 1 1 1 0 Spo7-like protein CsgF PF10614.9 VDK68084.1 - 0.1 12.8 0.1 0.11 12.7 0.1 1.2 1 0 0 1 1 1 0 Type VIII secretion system (T8SS), CsgF protein Pcc1 PF09341.10 VDK68086.1 - 3e-12 46.5 3.5 7.4e-12 45.2 0.0 3.6 4 0 0 4 4 4 1 Transcription factor Pcc1 GRIP PF01465.20 VDK68086.1 - 2.2e-09 37.1 2.4 5.5e-09 35.8 0.1 3.0 3 0 0 3 3 3 1 GRIP domain Spc7 PF08317.11 VDK68086.1 - 0.0036 16.2 17.7 0.0036 16.2 17.7 12.5 4 2 8 13 13 13 5 Spc7 kinetochore protein 2_5_RNA_ligase2 PF13563.6 VDK68086.1 - 0.21 11.5 2.0 5.2 7.0 0.1 3.4 3 0 0 3 3 3 0 2'-5' RNA ligase superfamily Methyltransf_16 PF10294.9 VDK68087.1 - 4.4e-16 59.1 0.1 6.9e-16 58.5 0.1 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 VDK68087.1 - 1.2e-09 38.1 0.0 1.6e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK68087.1 - 3.1e-08 34.2 0.0 5.4e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK68087.1 - 2.3e-07 30.8 0.0 4.7e-07 29.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 VDK68087.1 - 3.4e-07 30.0 0.0 4.6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 VDK68087.1 - 9.8e-07 29.3 0.0 1.8e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK68087.1 - 2.5e-05 23.9 0.0 3.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 VDK68087.1 - 0.00021 21.0 0.0 0.00029 20.5 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_12 PF08242.12 VDK68087.1 - 0.00098 19.8 0.0 0.0016 19.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 VDK68087.1 - 0.0085 15.1 0.0 0.011 14.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) GidB PF02527.15 VDK68087.1 - 0.022 14.1 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G MetW PF07021.12 VDK68087.1 - 0.072 12.7 0.2 0.18 11.4 0.2 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW CheR PF01739.18 VDK68087.1 - 0.074 12.5 0.0 0.73 9.3 0.0 2.0 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Ig_mannosidase PF17753.1 VDK68088.1 - 3.6e-11 42.6 0.0 7.4e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2_C PF02836.17 VDK68088.1 - 4.3e-06 26.1 0.0 1.9e-05 24.0 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 VDK68088.1 - 0.045 14.4 0.0 0.1 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 OTU PF02338.19 VDK68124.1 - 1.4e-25 90.3 0.0 5e-25 88.5 0.0 2.0 2 1 0 2 2 2 1 OTU-like cysteine protease Sec5 PF15469.6 VDK68125.1 - 1.3e-43 149.0 1.9 1.3e-43 149.0 1.9 2.3 3 0 0 3 3 3 1 Exocyst complex component Sec5 TIG PF01833.24 VDK68125.1 - 4.7e-09 36.2 0.0 9.4e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 IPT/TIG domain DUF3793 PF12672.7 VDK68125.1 - 0.078 13.0 0.4 0.3 11.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3793) Sec15 PF04091.12 VDK68125.1 - 0.43 9.9 11.2 0.071 12.5 0.4 3.0 3 1 1 4 4 4 0 Exocyst complex subunit Sec15-like Glyco_transf_18 PF15024.6 VDK68126.1 - 8.8e-16 57.6 0.3 1.6e-10 40.3 0.0 2.0 1 1 1 2 2 2 2 Glycosyltransferase family 18 Glyco_transf_18 PF15024.6 VDK68127.1 - 1.2e-05 24.2 0.0 1.3e-05 24.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 18 DNA_pol_B PF00136.21 VDK68129.1 - 9.6e-115 383.9 7.9 1.9e-114 382.9 7.9 1.5 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 VDK68129.1 - 6.2e-30 104.3 14.0 6.2e-30 104.3 14.0 2.2 2 0 0 2 2 2 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 VDK68129.1 - 1e-23 84.1 0.4 1e-23 84.1 0.4 2.1 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 VDK68129.1 - 7.8e-15 54.7 2.0 3.5e-14 52.6 2.0 2.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal YokU PF14122.6 VDK68129.1 - 0.11 12.5 1.3 0.57 10.2 1.3 2.2 1 0 0 1 1 1 0 YokU-like protein, putative antitoxin eIF-6 PF01912.18 VDK68131.1 - 1.2e-74 249.9 1.4 1.2e-74 249.9 1.4 1.3 2 0 0 2 2 2 1 eIF-6 family Diphthami_syn_2 PF01902.17 VDK68134.1 - 1.5e-42 145.6 0.0 2.4e-42 144.9 0.0 1.3 1 1 0 1 1 1 1 Diphthamide synthase CLTH PF10607.9 VDK68134.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain PTCB-BRCT PF12738.7 VDK68137.1 - 1.7e-40 136.8 15.3 6.3e-15 54.9 0.1 6.5 6 2 0 6 6 6 4 twin BRCT domain BRCT PF00533.26 VDK68137.1 - 1.7e-38 130.9 21.1 2.1e-08 34.4 0.0 7.0 7 0 0 7 7 7 6 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 VDK68137.1 - 1e-36 125.2 15.7 2e-06 28.1 0.2 6.9 7 0 0 7 7 7 6 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 VDK68137.1 - 3.5e-16 58.9 1.7 2.4e-07 30.6 0.0 5.3 5 0 0 5 5 5 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 VDK68137.1 - 7.6e-11 42.2 8.6 0.017 15.4 0.2 6.2 6 0 0 6 6 6 3 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 VDK68137.1 - 5e-10 39.4 7.9 0.00039 20.5 0.1 6.3 5 1 0 5 5 5 1 BRCA1 C Terminus (BRCT) domain TSCPD PF12637.7 VDK68137.1 - 3.1 8.1 4.6 7.6 6.9 0.2 2.8 2 0 0 2 2 2 0 TSCPD domain DUF1358 PF07096.11 VDK68139.1 - 0.0018 18.2 0.1 0.0025 17.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) Toluene_X PF03349.16 VDK68139.1 - 0.068 11.7 0.0 0.073 11.6 0.0 1.1 1 0 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) TMEM51 PF15345.6 VDK68139.1 - 0.14 12.0 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 PIG-L PF02585.17 VDK68140.1 - 3.6e-20 72.9 0.0 5e-20 72.5 0.0 1.1 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Adaptin_N PF01602.20 VDK68141.1 - 6.5e-143 477.0 15.0 8e-143 476.7 15.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 VDK68141.1 - 6.6e-15 55.5 9.8 1.9e-13 50.8 0.1 3.7 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 AP3B1_C PF14796.6 VDK68141.1 - 1.4e-09 38.3 0.2 5.6e-09 36.4 0.1 1.9 1 1 0 1 1 1 1 Clathrin-adaptor complex-3 beta-1 subunit C-terminal HEAT_2 PF13646.6 VDK68141.1 - 2.1e-06 28.0 7.6 0.0067 16.8 0.1 4.9 3 1 1 4 4 4 2 HEAT repeats SDA1 PF05285.12 VDK68141.1 - 0.00024 20.6 8.9 0.00033 20.2 8.9 1.1 1 0 0 1 1 1 1 SDA1 HEAT_EZ PF13513.6 VDK68141.1 - 0.0025 18.3 8.2 3.6 8.2 0.1 5.2 5 0 0 5 5 4 1 HEAT-like repeat MecA PF05389.12 VDK68141.1 - 0.011 15.4 4.4 0.019 14.6 4.4 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) HEAT PF02985.22 VDK68141.1 - 0.052 13.8 13.1 0.9 10.0 0.0 6.0 7 0 0 7 7 5 0 HEAT repeat Nop14 PF04147.12 VDK68141.1 - 0.3 9.3 20.6 0.58 8.3 20.6 1.4 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 VDK68141.1 - 0.31 9.8 6.0 0.57 8.9 6.0 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RRN3 PF05327.11 VDK68141.1 - 0.86 8.1 16.6 0.1 11.1 11.6 1.8 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 RP-C_C PF11800.8 VDK68141.1 - 3 7.9 4.4 5.5 7.0 4.4 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region PTPRCAP PF15713.5 VDK68141.1 - 3 8.1 17.5 20 5.4 18.8 1.6 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated RNA_pol_Rpc4 PF05132.14 VDK68141.1 - 9.9 6.6 6.9 20 5.6 6.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 WD40 PF00400.32 VDK68142.1 - 2.1e-20 72.7 0.9 1.6e-05 25.6 0.0 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK68142.1 - 8.2e-10 38.9 0.0 0.00048 20.4 0.0 4.4 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 VDK68142.1 - 0.026 14.5 0.4 0.094 12.7 0.0 2.1 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 VDK68142.1 - 0.09 12.3 0.0 0.2 11.2 0.0 1.5 2 0 0 2 2 2 0 PQQ-like domain WD40 PF00400.32 VDK68144.1 - 2.2e-30 104.3 6.6 7.9e-09 36.0 0.1 5.1 4 0 0 4 4 4 3 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 VDK68144.1 - 4.8e-23 81.8 1.5 8.1e-23 81.1 0.4 1.9 2 0 0 2 2 2 1 WD40 associated region in TFIID subunit, NTD2 domain Acetyltransf_1 PF00583.25 VDK68144.1 - 1.1e-12 48.2 0.0 2.6e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family ANAPC4_WD40 PF12894.7 VDK68144.1 - 3.8e-10 39.9 0.0 0.74 10.2 0.0 5.1 2 1 3 5 5 4 4 Anaphase-promoting complex subunit 4 WD40 domain Acetyltransf_7 PF13508.7 VDK68144.1 - 7.9e-09 35.8 0.0 1.6e-08 34.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 VDK68144.1 - 2.6e-05 24.1 0.0 6.6e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 VDK68144.1 - 0.00028 20.8 0.0 0.00062 19.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 VDK68144.1 - 0.00031 20.8 0.0 0.0018 18.3 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Ge1_WD40 PF16529.5 VDK68144.1 - 0.0044 16.0 0.0 1.2 8.0 0.0 2.5 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 VDK68144.1 - 0.0048 15.6 0.0 0.8 8.3 0.0 2.4 2 0 0 2 2 2 2 Nucleoporin Nup120/160 LisH PF08513.11 VDK68144.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 LisH Cytochrom_D1 PF02239.16 VDK68144.1 - 0.088 11.3 0.0 10 4.5 0.0 2.3 2 0 0 2 2 2 0 Cytochrome D1 heme domain PBP PF01161.20 VDK68145.1 - 1.5e-07 31.8 0.0 3.7e-06 27.3 0.0 2.3 1 1 1 2 2 2 1 Phosphatidylethanolamine-binding protein SH3BGR PF04908.15 VDK68146.1 - 6.6e-23 80.7 0.0 1.8e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 VDK68146.1 - 0.00033 20.8 0.0 0.00082 19.6 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin UPRTase PF14681.6 VDK68147.1 - 1.1e-17 64.2 0.0 1.4e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 VDK68147.1 - 0.0034 16.9 0.0 0.004 16.7 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 VDK68148.1 - 1.3e-18 67.2 0.0 1.6e-18 66.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase IBR PF01485.21 VDK68149.1 - 1.1e-07 32.0 46.5 1.6e-06 28.2 7.9 4.2 2 1 1 3 3 3 3 IBR domain, a half RING-finger domain Lipase_3 PF01764.25 VDK68150.1 - 1.3e-32 112.6 0.0 2.6e-32 111.6 0.0 1.5 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 VDK68150.1 - 0.018 14.3 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 VDK68150.1 - 0.022 15.4 0.0 0.028 15.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 VDK68150.1 - 0.048 13.4 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Phage_Gp111 PF07410.11 VDK68150.1 - 0.12 12.8 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 Streptococcus thermophilus bacteriophage Gp111 protein DUF2974 PF11187.8 VDK68150.1 - 0.16 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Clc-like PF07062.12 VDK68153.1 - 4.8e-68 228.8 7.9 5.7e-68 228.6 7.9 1.0 1 0 0 1 1 1 1 Clc-like PMP22_Claudin PF00822.20 VDK68153.1 - 0.00083 19.3 6.7 0.0075 16.2 0.0 2.3 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family SUR7 PF06687.12 VDK68153.1 - 0.0025 17.5 8.0 0.0099 15.5 8.0 2.0 1 1 1 2 2 2 1 SUR7/PalI family DUF4231 PF14015.6 VDK68153.1 - 3.4 8.2 6.2 5.9 7.4 1.7 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Mito_carr PF00153.27 VDK68155.1 - 4.4e-54 180.4 5.6 2.2e-20 72.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein IMD PF08397.11 VDK68156.1 - 2.1e-32 112.3 1.5 1.7e-27 96.3 0.6 2.2 1 1 0 2 2 2 2 IRSp53/MIM homology domain DUF2259 PF10016.9 VDK68156.1 - 0.048 13.6 0.2 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Predicted secreted protein (DUF2259) DUF948 PF06103.11 VDK68156.1 - 0.9 9.8 3.7 10 6.4 0.0 3.5 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Arfaptin PF06456.13 VDK68157.1 - 1.3e-58 198.3 9.3 1.8e-58 197.9 9.3 1.1 1 0 0 1 1 1 1 Arfaptin-like domain FHA PF00498.26 VDK68158.1 - 5.9e-18 65.0 0.0 1.9e-17 63.4 0.0 1.9 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 VDK68158.1 - 3e-05 24.3 0.3 0.0013 19.0 0.0 2.7 2 1 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain p25-alpha PF05517.12 VDK68159.1 - 2e-45 154.7 4.8 2.4e-45 154.5 4.8 1.1 1 0 0 1 1 1 1 p25-alpha Ribosomal_L13e PF01294.18 VDK68160.1 - 1.9e-78 262.5 8.6 1.9e-78 262.5 8.6 1.3 2 0 0 2 2 2 1 Ribosomal protein L13e Tcf25 PF04910.14 VDK68161.1 - 1.5e-73 247.9 10.7 2.1e-73 247.4 10.7 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 RNA_pol_Rpc34 PF05158.12 VDK68162.1 - 2e-56 191.8 2.3 1.1e-55 189.4 2.3 1.9 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.12 VDK68162.1 - 3.4e-05 23.9 0.2 0.0057 16.8 0.2 2.4 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC RPA_C PF08784.11 VDK68162.1 - 0.00021 21.9 0.3 1 10.0 0.2 2.4 2 0 0 2 2 2 2 Replication protein A C terminal MarR_2 PF12802.7 VDK68162.1 - 0.002 18.0 0.2 0.16 11.9 0.1 3.0 3 0 0 3 3 3 1 MarR family Rrf2 PF02082.20 VDK68162.1 - 0.0029 17.9 0.5 0.017 15.5 0.1 2.1 2 0 0 2 2 2 1 Transcriptional regulator TFIIE_alpha PF02002.17 VDK68162.1 - 0.0033 17.2 1.6 1 9.2 0.1 2.4 2 0 0 2 2 2 2 TFIIE alpha subunit HTH_IclR PF09339.10 VDK68162.1 - 0.02 14.7 0.0 0.36 10.7 0.0 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF4423 PF14394.6 VDK68162.1 - 0.022 14.4 0.1 5.1 6.8 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4423) FaeA PF04703.12 VDK68162.1 - 0.062 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 FaeA-like protein HTH_20 PF12840.7 VDK68162.1 - 0.063 13.4 0.0 0.56 10.3 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain GntR PF00392.21 VDK68162.1 - 0.099 12.3 0.1 0.26 11.0 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family TrmB PF01978.19 VDK68162.1 - 0.11 12.4 0.2 0.39 10.6 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB EF-hand_3 PF09069.11 VDK68164.1 - 2.2e-33 114.5 0.1 4.6e-32 110.3 0.0 3.6 2 0 0 2 2 2 1 EF-hand EF-hand_2 PF09068.11 VDK68164.1 - 3e-30 104.9 3.4 6.4e-30 103.8 0.5 3.3 3 0 0 3 3 3 1 EF hand Spectrin PF00435.21 VDK68164.1 - 7.3e-25 87.5 197.8 1e-11 45.2 5.2 21.3 21 3 2 23 23 23 10 Spectrin repeat ZZ PF00569.17 VDK68164.1 - 1.9e-14 53.2 6.3 3.6e-14 52.3 6.3 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type CH PF00307.31 VDK68164.1 - 1.1e-12 48.1 7.4 4.5e-09 36.5 0.0 4.8 6 0 0 6 6 6 2 Calponin homology (CH) domain WW PF00397.26 VDK68164.1 - 3.3e-06 27.1 2.0 4.2e-06 26.7 0.9 1.8 2 0 0 2 2 2 1 WW domain CAMSAP_CH PF11971.8 VDK68164.1 - 0.014 15.2 0.0 0.12 12.2 0.0 2.7 2 0 0 2 2 2 0 CAMSAP CH domain TraC PF07820.12 VDK68164.1 - 0.058 13.7 7.8 1.2 9.5 0.0 5.9 5 0 0 5 5 5 0 TraC-like protein PdxA PF04166.12 VDK68164.1 - 0.14 11.5 0.1 0.37 10.2 0.1 1.6 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA DEAD PF00270.29 VDK68165.1 - 1.3e-19 70.6 0.0 2.2e-19 69.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK68165.1 - 0.0016 18.5 0.2 0.0032 17.5 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MFS_1 PF07690.16 VDK68168.1 - 3.2e-20 72.4 30.3 8e-11 41.5 8.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 VDK68168.1 - 2.2e-05 23.5 24.2 0.0037 16.2 7.3 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Helicase_C PF00271.31 VDK68169.1 - 1.5e-28 99.4 0.9 1.1e-27 96.6 0.1 2.5 1 1 1 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK68169.1 - 5.4e-21 75.1 0.2 1.2e-20 74.0 0.2 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase TIP39 PF14980.6 VDK68169.1 - 0.014 15.3 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 TIP39 peptide AAA_22 PF13401.6 VDK68169.1 - 0.055 13.7 0.6 0.22 11.8 0.2 2.2 2 0 0 2 2 2 0 AAA domain RRN3 PF05327.11 VDK68170.1 - 2 6.9 13.9 0.18 10.3 9.3 1.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Pes-10 PF07149.11 VDK68170.1 - 3.7 6.5 9.5 6.3 5.7 9.5 1.3 1 0 0 1 1 1 0 Pes-10 DUF2457 PF10446.9 VDK68170.1 - 8.2 5.5 22.3 23 4.0 22.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) MtrF PF09472.10 VDK68289.1 - 0.0078 15.6 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Roc PF08477.13 VDK68290.1 - 1e-05 25.7 0.0 2.4e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DLIC PF05783.11 VDK68290.1 - 2.1e-05 23.6 0.0 4.6e-05 22.4 0.0 1.5 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) AAA_15 PF13175.6 VDK68290.1 - 0.00091 19.0 0.0 0.0015 18.3 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain Ras PF00071.22 VDK68290.1 - 0.0041 16.7 0.0 0.013 15.1 0.0 2.0 1 1 0 1 1 1 1 Ras family ATPase_2 PF01637.18 VDK68290.1 - 0.0055 16.6 0.6 0.016 15.2 0.0 2.0 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea Arf PF00025.21 VDK68290.1 - 0.0067 15.9 0.1 0.78 9.2 0.0 2.4 1 1 1 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 VDK68290.1 - 0.015 14.7 0.2 0.55 9.6 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit TniB PF05621.11 VDK68290.1 - 0.021 14.2 0.0 0.057 12.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 VDK68290.1 - 0.057 13.7 0.1 0.22 11.8 0.0 2.1 2 1 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 VDK68290.1 - 0.086 12.2 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region G_glu_transpept PF01019.21 VDK68291.1 - 8.7e-159 529.6 0.0 1e-158 529.4 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Kunitz_BPTI PF00014.23 VDK68293.1 - 1.6e-156 508.6 158.3 4.4e-18 65.3 7.5 11.7 11 0 0 11 11 11 11 Kunitz/Bovine pancreatic trypsin inhibitor domain Mcm10 PF09332.11 VDK68293.1 - 3.9e-63 214.0 20.9 3.9e-63 214.0 20.9 5.5 5 1 1 6 6 6 1 Mcm10 replication factor Lustrin_cystein PF14625.6 VDK68293.1 - 2.8e-18 66.0 48.6 6.7e-06 26.4 3.8 5.3 4 0 0 4 4 4 4 Lustrin, cysteine-rich repeated domain Thyroglobulin_1 PF00086.18 VDK68293.1 - 2.6e-10 39.8 0.8 2.6e-10 39.8 0.8 2.6 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat Peptidase_C1 PF00112.23 VDK68294.1 - 2e-74 250.3 0.0 3.5e-74 249.6 0.0 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 VDK68294.1 - 1.7e-10 41.2 0.2 3.6e-10 40.1 0.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 VDK68294.1 - 2.1e-07 30.1 0.1 1.9e-05 23.7 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Cystatin PF00031.21 VDK68294.1 - 0.002 18.4 0.1 0.0041 17.4 0.1 1.6 1 0 0 1 1 1 1 Cystatin domain GCV_T PF01571.21 VDK68296.1 - 2.6e-15 56.5 0.0 3.6e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain CS PF04969.16 VDK68299.1 - 1.6e-10 41.8 0.5 3.3e-10 40.9 0.5 1.5 1 0 0 1 1 1 1 CS domain SGS PF05002.15 VDK68299.1 - 7.7e-06 25.9 2.3 1.7e-05 24.8 2.3 1.6 1 0 0 1 1 1 1 SGS domain Siah-Interact_N PF09032.11 VDK68299.1 - 0.00071 19.8 2.6 0.00075 19.8 0.4 2.1 2 0 0 2 2 2 1 Siah interacting protein, N terminal Cep57_MT_bd PF06657.13 VDK68299.1 - 0.29 11.6 3.2 28 5.2 0.0 2.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 MerR-DNA-bind PF09278.11 VDK68299.1 - 0.43 11.2 1.9 1.2 9.7 1.2 2.0 1 1 1 2 2 2 0 MerR, DNA binding Enkurin PF13864.6 VDK68301.1 - 0.16 12.4 4.8 0.38 11.2 0.2 2.8 2 1 0 2 2 2 0 Calmodulin-binding SIX1_SD PF16878.5 VDK68302.1 - 4.9e-48 162.3 0.1 4.9e-48 162.3 0.1 1.8 3 0 0 3 3 3 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 VDK68302.1 - 9.2e-15 54.2 3.7 1.1e-14 54.0 1.4 2.2 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 VDK68302.1 - 7e-13 48.3 1.0 1.8e-12 46.9 1.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain PPP1R26_N PF15740.5 VDK68302.1 - 0.0014 17.4 0.9 0.0016 17.2 0.9 1.1 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 26 N-terminus DUF2967 PF11179.8 VDK68302.1 - 0.0096 14.1 2.8 0.013 13.7 2.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2967) Homez PF11569.8 VDK68302.1 - 0.033 13.6 0.0 0.088 12.3 0.0 1.8 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HTH_3 PF01381.22 VDK68302.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix Ly-6_related PF06579.12 VDK68303.1 - 5e-16 59.1 2.2 5.9e-16 58.9 2.2 1.1 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein QVR PF17064.5 VDK68303.1 - 0.0028 17.9 3.1 0.22 11.8 3.1 2.1 1 1 0 1 1 1 1 Sleepless protein Ank_4 PF13637.6 VDK68306.1 - 1e-20 73.8 0.5 4.2e-12 46.3 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK68306.1 - 7.6e-17 61.7 0.1 2.8e-16 59.9 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 VDK68306.1 - 3.2e-14 52.6 0.1 2.1e-06 27.9 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 VDK68306.1 - 5e-13 48.0 0.2 5.2e-05 23.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 VDK68306.1 - 1.7e-11 44.1 0.5 8.9e-07 29.1 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) SH3_1 PF00018.28 VDK68306.1 - 7.3e-09 35.1 0.0 1.5e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK68306.1 - 7e-08 32.2 0.5 1.7e-07 31.0 0.5 1.7 1 1 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK68306.1 - 0.002 17.8 0.0 0.0046 16.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RNA_pol_I_A49 PF06870.12 VDK68307.1 - 6.5e-38 130.6 0.0 8.6e-38 130.2 0.0 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor ERG4_ERG24 PF01222.17 VDK68308.1 - 2.5e-40 138.5 23.2 3.3e-40 138.2 23.2 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 VDK68308.1 - 1.7e-09 37.6 2.0 1.7e-09 37.6 2.0 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1295) ICMT PF04140.14 VDK68308.1 - 0.064 13.7 0.1 0.064 13.7 0.1 2.6 3 0 0 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Peptidase_S49_N PF08496.10 VDK68309.1 - 0.021 14.9 0.3 0.026 14.6 0.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal N6_Mtase PF02384.16 VDK68309.1 - 0.051 12.8 0.2 0.063 12.5 0.2 1.1 1 0 0 1 1 1 0 N-6 DNA Methylase Ribosomal_L2_C PF03947.18 VDK68311.1 - 2.2e-46 157.1 3.1 3.7e-46 156.4 3.1 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 VDK68311.1 - 8.7e-18 64.1 0.1 2.7e-17 62.5 0.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain His_Phos_1 PF00300.22 VDK68313.1 - 1e-08 35.1 0.0 3.2e-08 33.5 0.0 1.7 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 VDK68313.1 - 0.0029 17.0 0.0 0.014 14.7 0.0 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) CRS1_YhbY PF01985.21 VDK68313.1 - 0.085 13.0 0.1 0.2 11.8 0.0 1.6 2 0 0 2 2 2 0 CRS1 / YhbY (CRM) domain GATase_5 PF13507.6 VDK68316.1 - 0.022 13.9 0.0 0.047 12.8 0.0 1.5 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Choline_kinase PF01633.20 VDK68318.1 - 8.3e-31 107.2 0.0 3.5e-30 105.2 0.0 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase Neur_chan_LBD PF02931.23 VDK68319.1 - 1.7e-67 227.0 1.1 2.6e-67 226.4 1.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK68319.1 - 3.7e-32 112.3 1.9 8.1e-32 111.2 1.9 1.5 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Oxidored_q2 PF00420.24 VDK68319.1 - 3.6 7.3 7.7 0.97 9.1 1.2 2.6 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L RdRP PF05183.12 VDK68321.1 - 2.8e-138 462.2 0.0 4.2e-138 461.6 0.0 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase WD40 PF00400.32 VDK68321.1 - 3.2e-25 87.9 17.7 3e-06 27.9 0.0 8.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK68321.1 - 2e-11 44.0 2.3 0.0036 17.6 0.0 5.4 1 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK68321.1 - 4.3e-05 22.6 0.1 0.062 12.3 0.0 3.5 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein FERM_M PF00373.18 VDK68323.1 - 6.8e-14 52.3 0.0 1.2e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 FERM central domain Flavoprotein PF02441.19 VDK68324.1 - 6.2e-45 152.8 0.0 9e-45 152.3 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein ChaC PF04752.12 VDK68325.1 - 3.8e-52 176.9 0.0 4.9e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.12 VDK68325.1 - 0.00062 20.4 0.0 0.0011 19.5 0.0 1.4 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like An_peroxidase PF03098.15 VDK68325.1 - 0.23 10.0 0.0 0.32 9.5 0.0 1.1 1 0 0 1 1 1 0 Animal haem peroxidase VRR_NUC PF08774.11 VDK68327.1 - 1.3e-22 79.9 0.0 7.1e-22 77.5 0.0 2.3 2 0 0 2 2 2 1 VRR-NUC domain GST_C_3 PF14497.6 VDK68327.1 - 0.03 14.5 0.1 0.48 10.6 0.0 2.6 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain Ground-like PF04155.18 VDK68328.1 - 2.9e-20 72.7 1.4 4.7e-20 72.0 1.4 1.4 1 0 0 1 1 1 1 Ground-like domain CENP-W PF15510.6 VDK68329.1 - 0.11 12.7 0.0 0.42 10.9 0.0 1.9 1 0 0 1 1 1 0 CENP-W protein Zn_ribbon_17 PF17120.5 VDK68372.1 - 1.8e-05 24.2 9.5 1.8e-05 24.2 9.5 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 VDK68372.1 - 0.0019 18.4 1.5 0.0019 18.4 1.5 2.1 2 0 0 2 2 2 1 Zinc-ribbon like family NIF PF03031.18 VDK68374.1 - 5.1e-49 166.0 0.0 6.5e-49 165.7 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF5645 PF18713.1 VDK68375.1 - 0.0071 16.7 0.2 0.01 16.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5645) GATase PF00117.28 VDK68377.1 - 7.2e-37 127.0 0.0 1.3e-36 126.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 VDK68377.1 - 1e-16 60.7 0.0 3.1e-08 33.5 0.0 3.2 2 1 0 2 2 2 2 GMP synthase C terminal domain Peptidase_C26 PF07722.13 VDK68377.1 - 5.4e-11 42.7 0.0 1.4e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 VDK68377.1 - 1e-10 41.1 0.0 2.9e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 NAD synthase ThiI PF02568.14 VDK68377.1 - 8e-05 22.3 0.1 0.00016 21.3 0.1 1.5 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) QueC PF06508.13 VDK68377.1 - 9.2e-05 22.0 0.0 0.00053 19.6 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 VDK68377.1 - 0.00045 19.1 0.2 0.0023 16.8 0.1 1.9 2 0 0 2 2 2 1 tRNA methyl transferase ATP_bind_3 PF01171.20 VDK68377.1 - 0.0022 17.8 0.1 0.0045 16.8 0.1 1.5 1 0 0 1 1 1 1 PP-loop family Asn_synthase PF00733.21 VDK68377.1 - 0.014 15.1 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase Med8 PF10232.9 VDK68378.1 - 6.9e-24 84.7 2.6 1.9e-23 83.3 2.6 1.6 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 ETRAMP PF09716.10 VDK68378.1 - 0.047 13.8 0.1 0.14 12.2 0.1 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PPP1R35_C PF15503.6 VDK68379.1 - 1.8e-06 27.8 1.0 2.3e-06 27.5 1.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 1 regulatory subunit 35 C-terminus Med26 PF08711.11 VDK68381.1 - 4.3e-05 23.4 0.3 9.2e-05 22.4 0.3 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain IFT43 PF15305.6 VDK68385.1 - 5.7e-15 55.7 0.1 9.4e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Intraflagellar transport protein 43 V_ATPase_I PF01496.19 VDK68387.1 - 3.4e-249 829.1 22.6 2.7e-192 640.9 2.9 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family MPS2 PF17060.5 VDK68387.1 - 0.079 12.2 0.1 0.22 10.7 0.1 1.7 1 0 0 1 1 1 0 Monopolar spindle protein 2 PCRF PF03462.18 VDK68387.1 - 0.2 11.5 0.7 0.96 9.3 0.1 2.0 2 0 0 2 2 2 0 PCRF domain BEX PF04538.12 VDK68387.1 - 0.62 10.7 0.1 0.62 10.7 0.1 1.8 2 0 0 2 2 2 0 Brain expressed X-linked like family Motile_Sperm PF00635.26 VDK68388.1 - 9.1e-21 73.8 0.0 1.1e-20 73.5 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF4909 PF16253.5 VDK68388.1 - 0.089 12.6 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4909) Y_phosphatase PF00102.27 VDK68392.1 - 2.6e-68 230.1 2.6 3.5e-68 229.7 2.6 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 VDK68392.1 - 1.3e-05 25.3 0.0 2.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 VDK68392.1 - 0.00052 19.8 0.4 0.00052 19.8 0.4 2.5 2 1 1 3 3 3 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 VDK68392.1 - 0.0024 18.0 0.0 0.0052 16.9 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate DEAD PF00270.29 VDK68392.1 - 0.0055 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase RHD_dimer PF16179.5 VDK68392.1 - 0.066 13.2 0.1 0.26 11.3 0.0 2.0 1 1 1 2 2 2 0 Rel homology dimerisation domain WD40 PF00400.32 VDK68395.1 - 4.5e-12 46.3 1.3 2e-05 25.2 0.1 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.8 VDK68395.1 - 0.0097 14.6 0.1 0.48 9.0 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 VDK68395.1 - 0.061 13.6 0.0 12 6.2 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S9_N PF02897.15 VDK68395.1 - 0.086 11.6 0.1 0.24 10.1 0.0 1.6 2 0 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Hira PF07569.11 VDK68395.1 - 0.1 12.3 0.0 64 3.2 0.0 3.3 4 0 0 4 4 4 0 TUP1-like enhancer of split HEAT_EZ PF13513.6 VDK68397.1 - 2.9e-33 113.8 10.3 5e-12 46.0 0.0 10.6 7 2 4 11 11 11 7 HEAT-like repeat HEAT PF02985.22 VDK68397.1 - 1.4e-17 62.3 18.9 0.051 13.8 0.0 11.3 11 0 0 11 11 11 3 HEAT repeat Vac14_Fab1_bd PF12755.7 VDK68397.1 - 2.6e-15 56.8 0.0 0.0085 16.7 0.0 6.9 5 2 2 7 7 7 4 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 VDK68397.1 - 2.6e-12 46.5 0.2 7.2e-12 45.1 0.2 1.8 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cnd1 PF12717.7 VDK68397.1 - 5e-12 46.1 0.1 0.00077 19.5 0.0 4.7 4 1 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 VDK68397.1 - 6.3e-12 45.3 9.3 0.00058 19.1 0.0 6.1 5 1 2 7 7 7 5 RNAPII transcription regulator C-terminal HEAT_2 PF13646.6 VDK68397.1 - 8.2e-11 42.2 0.3 0.19 12.1 0.0 6.3 4 2 1 6 6 6 2 HEAT repeats Arm PF00514.23 VDK68397.1 - 4.7e-08 32.8 11.2 0.38 10.9 0.0 7.6 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat DUF3385 PF11865.8 VDK68397.1 - 2.8e-07 30.6 0.0 0.097 12.6 0.0 5.2 4 2 2 6 6 6 1 Domain of unknown function (DUF3385) Adaptin_N PF01602.20 VDK68397.1 - 1.7e-06 26.9 2.5 0.034 12.7 0.1 3.0 2 1 0 2 2 2 2 Adaptin N terminal region CLASP_N PF12348.8 VDK68397.1 - 0.011 15.3 0.2 0.56 9.7 0.0 3.2 3 0 0 3 3 3 0 CLASP N terminal Proteasom_PSMB PF10508.9 VDK68397.1 - 0.019 13.5 0.1 0.11 11.0 0.0 2.2 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit RIX1 PF08167.12 VDK68397.1 - 0.021 14.6 0.4 14 5.4 0.1 4.2 3 1 1 4 4 4 0 rRNA processing/ribosome biogenesis UME PF08064.13 VDK68397.1 - 0.024 14.5 1.5 14 5.7 0.1 5.0 4 2 1 5 5 4 0 UME (NUC010) domain DUF3437 PF11919.8 VDK68397.1 - 0.15 12.0 0.0 15 5.5 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) Tti2 PF10521.9 VDK68397.1 - 0.43 10.1 4.3 23 4.4 0.0 4.2 2 2 1 4 4 4 0 Tti2 family Neur_chan_LBD PF02931.23 VDK68401.1 - 1.8e-32 112.5 10.7 7.1e-29 100.8 7.0 2.3 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK68401.1 - 0.0051 16.9 1.0 0.013 15.5 0.9 1.8 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 VDK68402.1 - 1.9e-21 76.5 0.1 3.5e-21 75.6 0.1 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK68402.1 - 8.1e-16 58.8 3.5 2.1e-15 57.5 3.5 1.6 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Claudin_3 PF06653.11 VDK68402.1 - 0.34 10.8 5.8 0.31 11.0 0.3 2.4 2 0 0 2 2 2 0 Tight junction protein, Claudin-like MNHE PF01899.16 VDK68403.1 - 0.19 11.5 0.0 1 9.1 0.0 1.9 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit CNDH2_C PF16858.5 VDK68404.1 - 0.051 13.5 0.1 0.08 12.8 0.1 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PUF PF00806.19 VDK68410.1 - 1.8e-40 134.4 10.7 5.3e-05 22.7 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Imm30 PF15565.6 VDK68410.1 - 0.028 14.5 0.1 0.088 12.9 0.1 1.9 1 0 0 1 1 1 0 Immunity protein 30 Mei5_like PF17021.5 VDK68410.1 - 0.067 13.2 0.2 0.21 11.7 0.1 1.8 2 0 0 2 2 2 0 Putative double-strand recombination repair-like Nucleotid_trans PF03407.16 VDK68412.1 - 2.4e-31 109.4 0.2 3.4e-31 108.9 0.2 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase HCO3_cotransp PF00955.21 VDK68416.1 - 4.3e-161 537.2 9.0 5.9e-161 536.7 9.0 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 VDK68416.1 - 0.1 12.4 1.0 0.24 11.1 0.1 2.0 2 0 0 2 2 2 0 Band 3 cytoplasmic domain OAD_gamma PF04277.13 VDK68418.1 - 0.093 13.3 6.9 0.88 10.2 6.9 2.1 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF5385 PF17359.2 VDK68418.1 - 0.12 11.9 7.2 6.4 6.3 7.2 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5385) TDP43_N PF18694.1 VDK68420.1 - 2e-19 69.2 0.0 4.5e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain MPS2 PF17060.5 VDK68420.1 - 0.0065 15.8 2.5 0.0065 15.8 2.5 2.1 2 1 0 2 2 2 1 Monopolar spindle protein 2 HALZ PF02183.18 VDK68420.1 - 0.0089 16.2 0.6 0.039 14.2 0.6 2.2 1 0 0 1 1 1 1 Homeobox associated leucine zipper CASP_C PF08172.12 VDK68420.1 - 4.5 6.5 13.2 36 3.6 1.9 2.6 1 1 1 2 2 2 0 CASP C terminal UPF0242 PF06785.11 VDK68420.1 - 9.1 6.3 20.6 3.8 7.6 3.6 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Collagen PF01391.18 VDK68422.1 - 7.5e-22 76.9 96.9 1.3e-09 37.7 27.9 5.0 3 1 1 4 4 4 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK68422.1 - 2e-18 66.2 1.5 2.6e-18 65.8 1.5 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain LRR19-TM PF15176.6 VDK68422.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Phage_TAC_11 PF11836.8 VDK68423.1 - 0.096 12.8 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 CAAP1 PF15335.6 VDK68424.1 - 2.8e-18 66.2 0.5 4.8e-18 65.5 0.5 1.4 1 0 0 1 1 1 1 Caspase activity and apoptosis inhibitor 1 Pkinase_Tyr PF07714.17 VDK68427.1 - 1.3e-74 250.7 0.0 3.1e-74 249.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 VDK68427.1 - 8e-46 156.5 0.0 1.8e-45 155.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain MA3 PF02847.17 VDK68427.1 - 6.4e-22 77.7 2.1 7.1e-15 55.0 0.6 3.1 2 0 0 2 2 2 2 MA3 domain MIF4G PF02854.19 VDK68427.1 - 2.6e-14 53.4 1.8 6.8e-14 52.0 1.8 1.8 1 0 0 1 1 1 1 MIF4G domain SH2 PF00017.24 VDK68427.1 - 2e-07 31.0 0.0 9.6e-07 28.8 0.0 2.3 1 1 0 1 1 1 1 SH2 domain Cnd1 PF12717.7 VDK68427.1 - 0.0068 16.5 2.1 0.011 15.8 0.6 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Kinase-like PF14531.6 VDK68427.1 - 0.048 13.0 0.0 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF2367 PF10164.9 VDK68433.1 - 1.3e-06 28.8 2.7 1.3e-06 28.8 2.7 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2367) DUF3395 PF11875.8 VDK68434.1 - 1.4e-35 122.5 0.0 2.4e-35 121.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 VDK68434.1 - 8.9e-19 67.4 0.7 8.9e-19 67.4 0.7 1.8 2 0 0 2 2 2 1 DnaJ domain Metallophos PF00149.28 VDK68435.1 - 1.3e-29 104.2 0.0 1.8e-29 103.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK68435.1 - 0.00029 21.2 0.3 0.0011 19.4 0.3 2.0 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Nitrate_red_gam PF02665.14 VDK68435.1 - 0.16 11.5 0.1 0.25 10.9 0.1 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit VPS9 PF02204.18 VDK68481.1 - 0.13 12.5 0.9 0.34 11.2 0.1 2.1 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain DHFR_1 PF00186.19 VDK68482.1 - 2.9e-38 131.1 0.0 3.7e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase DASH_Dad1 PF08649.10 VDK68482.1 - 0.33 11.2 2.4 0.57 10.4 2.4 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad1 DUF2428 PF10350.9 VDK68483.1 - 2.6e-60 204.0 0.8 6.9e-60 202.6 0.8 1.7 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 VDK68483.1 - 0.00026 21.0 6.5 5 7.7 0.0 6.1 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 VDK68483.1 - 0.0059 17.0 0.1 0.036 14.5 0.1 2.3 2 0 0 2 2 2 1 HEAT repeats LCAT PF02450.15 VDK68485.1 - 2.5e-82 277.2 5.7 5.6e-81 272.7 5.7 2.0 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 VDK68485.1 - 0.0023 17.5 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 VDK68485.1 - 0.017 14.4 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 VDK68485.1 - 0.022 14.5 0.3 1.7 8.3 0.5 2.4 2 1 0 2 2 2 0 PGAP1-like protein Abhydrolase_6 PF12697.7 VDK68485.1 - 0.048 14.3 0.0 0.082 13.5 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF5052 PF16475.5 VDK68485.1 - 0.14 11.8 0.0 0.57 9.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5052) KH_1 PF00013.29 VDK68486.1 - 6.6e-44 147.6 16.1 3.8e-19 68.3 2.0 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 VDK68486.1 - 8.7e-14 51.1 9.3 4.2e-06 26.5 0.4 3.3 2 1 1 3 3 3 3 KH domain KH_5 PF13184.6 VDK68486.1 - 3e-09 36.8 5.9 0.03 14.4 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 VDK68486.1 - 3.3e-07 30.1 5.7 0.0051 16.7 0.3 3.6 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 VDK68486.1 - 0.0017 18.3 0.1 0.071 13.1 0.0 2.7 3 0 0 3 3 3 1 KH-like RNA-binding domain RuvC PF02075.17 VDK68486.1 - 0.029 14.3 0.7 0.06 13.2 0.7 1.5 1 1 0 1 1 1 0 Crossover junction endodeoxyribonuclease RuvC Citrate_bind PF16114.5 VDK68486.1 - 0.11 12.0 0.1 0.25 10.8 0.1 1.5 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding DUF1387 PF07139.11 VDK68487.1 - 4.8e-16 59.4 4.8 4.8e-16 59.4 4.8 2.3 1 1 0 2 2 2 1 Protein of unknown function (DUF1387) DUF1296 PF06972.11 VDK68487.1 - 0.0029 17.7 0.2 0.0074 16.4 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) HBS1_N PF08938.10 VDK68487.1 - 0.037 14.3 0.1 0.037 14.3 0.1 2.5 3 0 0 3 3 3 0 HBS1 N-terminus CaKB PF03185.15 VDK68488.1 - 0.54 9.9 2.6 0.64 9.6 1.7 1.5 2 0 0 2 2 2 0 Calcium-activated potassium channel, beta subunit WD40 PF00400.32 VDK68489.1 - 2.9e-21 75.4 4.8 2.1e-06 28.3 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK68489.1 - 1.4e-09 38.1 0.0 0.028 14.7 0.0 4.8 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 VDK68489.1 - 0.0053 16.4 0.0 0.0091 15.6 0.0 1.4 1 0 0 1 1 1 1 PQQ-like domain Nup160 PF11715.8 VDK68489.1 - 0.025 13.3 0.1 3 6.4 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Homeodomain PF00046.29 VDK68491.1 - 1.7e-15 56.6 0.8 5.9e-15 54.9 0.1 2.1 2 0 0 2 2 2 1 Homeodomain LIM PF00412.22 VDK68491.1 - 2.8e-11 43.5 6.3 5.6e-11 42.5 6.3 1.5 1 0 0 1 1 1 1 LIM domain Homeobox_KN PF05920.11 VDK68491.1 - 0.0004 20.2 0.0 0.0012 18.7 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain NAD_binding_1 PF00175.21 VDK68491.1 - 0.15 12.7 0.6 20 5.9 0.1 2.6 2 1 1 3 3 3 0 Oxidoreductase NAD-binding domain DUF5596 PF18082.1 VDK68491.1 - 0.18 11.7 0.1 0.37 10.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5596) zf_UBZ PF18439.1 VDK68491.1 - 1.4 8.6 4.4 10 5.8 0.2 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger NCD3G PF07562.14 VDK68491.1 - 1.7 8.6 8.0 23 5.0 0.1 3.0 2 1 1 3 3 3 0 Nine Cysteines Domain of family 3 GPCR LIM PF00412.22 VDK68492.1 - 8.8e-10 38.7 8.7 1.6e-09 37.8 8.7 1.4 1 0 0 1 1 1 1 LIM domain Headcase PF16002.5 VDK68494.1 - 4.9e-55 186.1 2.8 6.4e-55 185.7 2.8 1.1 1 0 0 1 1 1 1 Headcase protein DUF4993 PF16384.5 VDK68494.1 - 0.077 12.0 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function BSD PF03909.17 VDK68496.1 - 4.9e-14 52.1 0.5 1.7e-13 50.4 0.5 2.0 1 0 0 1 1 1 1 BSD domain SelB-wing_1 PF09105.10 VDK68496.1 - 0.15 12.1 0.4 0.39 10.7 0.4 1.7 1 0 0 1 1 1 0 Elongation factor SelB, winged helix Exo_endo_phos PF03372.23 VDK68497.1 - 7.2e-10 38.8 0.2 1.2e-09 38.1 0.2 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ASH PF15780.5 VDK68497.1 - 0.0012 19.0 0.1 0.0044 17.2 0.0 1.9 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin RhoGAP PF00620.27 VDK68497.1 - 0.0051 16.6 0.0 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain Lsm_interact PF05391.11 VDK68497.1 - 0.16 11.5 1.7 0.33 10.5 0.7 2.0 2 0 0 2 2 2 0 Lsm interaction motif Exo_endo_phos PF03372.23 VDK68499.1 - 6.9e-11 42.1 0.0 1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.22 VDK68500.1 - 3.2e-36 123.0 0.0 8.6e-12 44.7 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK68500.1 - 0.024 14.8 0.0 11 6.2 0.0 3.4 3 1 0 3 3 3 0 RNA recognition motif PHM7_cyt PF14703.6 VDK68500.1 - 0.037 14.2 0.0 1.2 9.4 0.0 3.0 2 2 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DPPIV_N PF00930.21 VDK68501.1 - 6.1e-57 193.0 2.9 1.1e-40 139.5 1.1 2.3 1 1 1 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 VDK68501.1 - 8.7e-34 116.9 1.0 7.9e-25 87.6 0.2 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 VDK68501.1 - 0.003 16.9 0.0 0.14 11.4 0.0 2.5 1 1 1 2 2 2 1 Serine aminopeptidase, S33 DLH PF01738.18 VDK68501.1 - 0.0053 16.3 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family Stm1_N PF09598.10 VDK68502.1 - 0.13 13.1 1.9 0.71 10.8 0.1 2.2 2 0 0 2 2 2 0 Stm1 Sema PF01403.19 VDK68504.1 - 1.5e-86 290.8 0.0 2.4e-86 290.2 0.0 1.3 1 0 0 1 1 1 1 Sema domain Ig_3 PF13927.6 VDK68504.1 - 3.4e-05 24.4 0.2 0.00014 22.4 0.2 2.0 2 0 0 2 2 2 1 Immunoglobulin domain PSI PF01437.25 VDK68504.1 - 0.00018 22.0 6.6 0.00018 22.0 6.6 2.5 2 0 0 2 2 2 1 Plexin repeat I-set PF07679.16 VDK68504.1 - 0.00063 19.8 0.1 0.0015 18.5 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_2 PF13895.6 VDK68504.1 - 0.0011 19.2 0.2 0.0059 16.9 0.1 2.3 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 VDK68504.1 - 0.0095 16.1 0.8 0.14 12.3 0.2 2.8 3 0 0 3 3 3 1 Immunoglobulin domain V-set PF07686.17 VDK68504.1 - 0.086 13.0 0.4 0.83 9.9 0.1 2.7 2 1 1 3 3 3 0 Immunoglobulin V-set domain Tyrosinase PF00264.20 VDK68509.1 - 2e-32 113.3 0.6 2e-32 113.3 0.6 2.0 2 1 0 2 2 2 1 Common central domain of tyrosinase Tyrosinase PF00264.20 VDK68512.1 - 1.7e-35 123.4 0.2 1.3e-34 120.5 0.2 2.2 1 1 0 1 1 1 1 Common central domain of tyrosinase ShK PF01549.24 VDK68512.1 - 3.2e-24 85.2 68.4 1.1e-07 32.3 9.6 5.3 4 0 0 4 4 4 4 ShK domain-like zf-CCCH PF00642.24 VDK68512.1 - 2.4 8.2 19.7 0.47 10.4 0.2 5.3 4 1 0 4 4 4 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) vATP-synt_AC39 PF01992.16 VDK68515.1 - 7e-110 367.7 1.1 8.2e-110 367.4 1.1 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Ribosomal_S19 PF00203.21 VDK68516.1 - 2.8e-33 113.7 0.1 4.1e-33 113.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 ABC_tran PF00005.27 VDK68518.1 - 9.2e-09 35.9 0.1 3.3e-08 34.1 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 VDK68518.1 - 2.2e-07 31.0 0.0 3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 VDK68518.1 - 0.012 15.1 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Innexin PF00876.18 VDK68520.1 - 4.3e-94 315.7 17.8 5.5e-94 315.3 17.8 1.0 1 0 0 1 1 1 1 Innexin OrfA PF17495.2 VDK68520.1 - 0.25 11.5 1.7 0.9 9.7 0.3 2.4 2 0 0 2 2 2 0 Vpr-like OrfA Amidase PF01425.21 VDK68523.1 - 6.8e-81 272.5 0.0 8.7e-81 272.2 0.0 1.1 1 0 0 1 1 1 1 Amidase NTF2 PF02136.20 VDK68527.1 - 4.6e-18 65.9 0.1 5.2e-18 65.7 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 VDK68527.1 - 0.0019 18.1 0.0 0.0022 18.0 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 Phage_Coat_Gp8 PF05371.12 VDK68527.1 - 0.02 14.7 0.0 0.044 13.6 0.0 1.6 1 0 0 1 1 1 0 Phage major coat protein, Gp8 AdoHcyase PF05221.17 VDK68528.1 - 6.1e-134 445.8 0.0 4.9e-73 245.9 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 VDK68528.1 - 8.9e-82 273.0 2.7 1.4e-81 272.4 2.7 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 VDK68528.1 - 1.9e-07 30.6 0.2 3.3e-07 29.9 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 VDK68528.1 - 0.00017 21.2 0.8 0.0003 20.4 0.8 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 VDK68528.1 - 0.0029 17.9 0.1 0.0063 16.8 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain ELFV_dehydrog PF00208.21 VDK68528.1 - 0.022 14.5 0.2 0.038 13.7 0.2 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_7 PF13241.6 VDK68528.1 - 0.058 13.8 0.5 0.24 11.8 0.8 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 VDK68528.1 - 0.17 12.0 0.5 0.31 11.1 0.5 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Cpn60_TCP1 PF00118.24 VDK68529.1 - 6.9e-153 509.8 10.3 7.9e-153 509.6 10.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DDA1 PF10172.9 VDK68533.1 - 1.3e-09 38.2 0.4 3.5e-09 36.8 0.4 1.8 1 1 0 1 1 1 1 Det1 complexing ubiquitin ligase CIAPIN1 PF05093.13 VDK68534.1 - 2.4e-21 76.1 10.2 5e-16 59.0 2.8 2.3 1 1 1 2 2 2 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DUF4525 PF15027.6 VDK68535.1 - 0.026 14.2 0.5 0.084 12.6 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) DivIC PF04977.15 VDK68535.1 - 0.035 13.9 2.7 0.087 12.6 0.6 2.6 2 0 0 2 2 2 0 Septum formation initiator Glyco_hydro_98C PF08307.11 VDK68535.1 - 0.035 13.6 0.7 0.073 12.5 0.7 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 C-terminal domain FAT PF02259.23 VDK68536.1 - 1.5e-67 228.3 10.9 1e-51 176.2 8.5 3.3 2 1 1 3 3 3 2 FAT domain DUF3385 PF11865.8 VDK68536.1 - 4e-50 169.9 9.3 3.5e-45 153.8 0.1 5.0 4 1 0 4 4 4 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 VDK68536.1 - 1.2e-22 80.1 5.0 6.4e-22 77.8 0.1 4.5 4 1 1 5 5 5 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 VDK68536.1 - 1.3e-11 44.8 5.3 0.099 13.0 0.0 8.4 6 2 2 9 9 8 3 HEAT repeats HEAT PF02985.22 VDK68536.1 - 1.4e-08 34.3 7.0 0.36 11.2 0.1 7.4 6 0 0 6 6 6 2 HEAT repeat Sec7_N PF12783.7 VDK68536.1 - 0.00057 19.8 0.1 0.00057 19.8 0.1 6.0 7 2 1 8 8 8 1 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_EZ PF13513.6 VDK68536.1 - 0.00071 20.0 17.3 0.019 15.5 0.1 8.5 9 2 2 11 11 9 1 HEAT-like repeat RIX1 PF08167.12 VDK68536.1 - 0.0072 16.1 7.5 4.3 7.0 0.1 5.6 4 3 3 7 7 7 1 rRNA processing/ribosome biogenesis TPR_7 PF13176.6 VDK68536.1 - 0.049 13.7 0.1 0.83 9.8 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK68536.1 - 0.051 14.2 1.9 5.3 7.9 0.0 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat IFRD PF05004.13 VDK68536.1 - 0.055 12.6 6.7 0.095 11.8 0.1 4.0 4 1 1 5 5 5 0 Interferon-related developmental regulator (IFRD) TPR_17 PF13431.6 VDK68536.1 - 0.11 12.9 1.9 0.71 10.4 0.5 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Telomere_reg-2 PF10193.9 VDK68536.1 - 9.2 6.8 18.5 1.6 9.2 0.1 6.1 8 1 0 8 8 7 0 Telomere length regulation protein Aldedh PF00171.22 VDK68604.1 - 3.1e-164 546.9 0.3 3.9e-164 546.6 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Peptidase_C92 PF05708.12 VDK68604.1 - 2.4e-05 24.5 0.0 6.3e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DUF1487 PF07368.11 VDK68604.1 - 0.0015 18.1 0.1 0.25 10.7 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) Lipase_3 PF01764.25 VDK68606.1 - 5.3e-17 62.0 0.0 8.9e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 VDK68606.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PP2C PF00481.21 VDK68607.1 - 6.6e-72 242.2 1.2 2.7e-56 191.1 0.4 2.5 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 VDK68607.1 - 8.3e-05 22.3 0.0 0.017 14.8 0.0 2.6 2 1 0 2 2 2 2 Protein phosphatase 2C Glutaredoxin PF00462.24 VDK68608.1 - 6.8e-14 51.8 0.0 9.5e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin CRT10 PF08728.10 VDK68608.1 - 0.065 11.4 0.0 0.074 11.2 0.0 1.0 1 0 0 1 1 1 0 CRT10 DUF4628 PF15429.6 VDK68608.1 - 0.075 12.7 0.0 0.09 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) Metallophos PF00149.28 VDK68609.1 - 2.9e-41 142.2 0.0 4e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK68609.1 - 0.00014 22.3 0.7 0.00027 21.3 0.7 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain IP_trans PF02121.18 VDK68610.1 - 2.8e-76 256.3 2.6 1.3e-74 250.9 2.6 2.2 1 1 0 1 1 1 1 Phosphatidylinositol transfer protein DDHD PF02862.17 VDK68610.1 - 1.6e-20 74.2 6.1 5.8e-12 46.3 0.2 2.7 2 1 1 3 3 3 2 DDHD domain LNS2 PF08235.13 VDK68610.1 - 0.00049 19.7 0.1 0.0031 17.0 0.1 2.0 1 1 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) PRP3 PF08572.10 VDK68612.1 - 1.9e-43 148.8 2.2 1.2e-26 93.8 1.5 3.8 3 2 1 4 4 4 2 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 VDK68612.1 - 8.3e-39 133.0 1.3 8.3e-39 133.0 1.3 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1115) PulG PF11773.8 VDK68612.1 - 0.66 9.8 3.7 0.38 10.6 0.1 2.4 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin Ribosomal_L21e PF01157.18 VDK68614.1 - 2.1e-46 155.9 3.9 2.1e-46 155.9 3.9 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e UCR_UQCRX_QCR9 PF05365.12 VDK68615.1 - 2.1e-15 56.4 1.0 3.1e-15 55.9 0.4 1.5 1 1 1 2 2 2 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like G10 PF01125.17 VDK68616.1 - 8.5e-66 220.2 5.2 9.7e-66 220.0 5.2 1.0 1 0 0 1 1 1 1 G10 protein DNA_pol_A PF00476.20 VDK68617.1 - 2.1e-103 346.3 0.1 4.2e-103 345.3 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase family A Homeodomain PF00046.29 VDK68618.1 - 2.5e-12 46.5 0.1 4.4e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK68618.1 - 0.019 14.9 0.1 0.043 13.7 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain Helicase_C PF00271.31 VDK68619.1 - 1.1e-10 41.9 0.0 1.2e-10 41.8 0.0 1.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HTH_38 PF13936.6 VDK68619.1 - 0.026 14.3 0.3 0.041 13.7 0.3 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain DEAD PF00270.29 VDK68620.1 - 3.3e-17 62.8 0.0 6.4e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK68620.1 - 1.3e-06 28.5 0.0 3.4e-06 27.2 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF871 PF05913.11 VDK68620.1 - 0.0056 15.9 0.0 0.013 14.8 0.0 1.5 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF871) T2SSE PF00437.20 VDK68620.1 - 0.022 13.8 0.0 0.055 12.5 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 VDK68620.1 - 0.03 14.6 0.0 0.12 12.6 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 VDK68620.1 - 0.036 14.5 0.0 0.11 13.0 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Kinesin PF00225.23 VDK68622.1 - 3.1e-105 351.8 0.2 3.1e-105 351.8 0.2 2.7 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 VDK68622.1 - 2.3e-24 86.0 0.0 1.2e-23 83.8 0.0 2.3 1 0 0 1 1 1 1 Microtubule binding DASH_Hsk3 PF08227.11 VDK68622.1 - 0.5 10.8 0.0 0.5 10.8 0.0 4.2 5 0 0 5 5 5 0 DASH complex subunit Hsk3 like Lyase_1 PF00206.20 VDK68625.1 - 6.6e-121 403.5 0.0 8.8e-121 403.1 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 VDK68625.1 - 1.2e-27 96.0 0.3 4.2e-27 94.3 0.1 2.1 2 0 0 2 2 2 1 Fumarase C C-terminus Cpn60_TCP1 PF00118.24 VDK68626.1 - 2e-154 514.9 2.9 2.6e-154 514.5 2.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family bZIP_1 PF00170.21 VDK68627.1 - 9.6e-06 25.6 7.2 2.1e-05 24.5 7.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 VDK68627.1 - 0.00022 21.2 8.1 0.00051 20.1 8.1 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 VDK68627.1 - 0.14 12.7 4.8 0.34 11.5 4.8 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor WD40 PF00400.32 VDK68630.1 - 4.9e-06 27.2 3.6 0.00041 21.1 0.5 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK68630.1 - 0.00011 22.5 0.0 0.74 10.2 0.0 4.1 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 VDK68630.1 - 0.0062 15.2 0.0 0.01 14.5 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 DUF2316 PF10078.9 VDK68631.1 - 0.081 13.2 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) HEAT PF02985.22 VDK68634.1 - 2.4e-38 126.8 29.4 0.0023 18.0 0.0 20.9 20 0 0 20 20 20 8 HEAT repeat HEAT_2 PF13646.6 VDK68634.1 - 2.1e-22 79.3 19.7 0.0012 19.2 0.1 12.7 8 4 4 12 12 12 5 HEAT repeats HEAT_EZ PF13513.6 VDK68634.1 - 1.3e-21 76.6 26.0 0.034 14.6 0.0 14.7 15 1 1 16 16 15 6 HEAT-like repeat Vac14_Fab1_bd PF12755.7 VDK68634.1 - 1.2e-13 51.5 2.8 0.42 11.2 0.0 9.9 8 3 2 10 10 9 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 VDK68634.1 - 1.7e-13 51.0 11.0 0.0014 18.7 0.0 9.7 7 2 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 VDK68634.1 - 1.5e-11 44.4 13.0 7.7e-05 22.4 0.0 8.0 7 1 1 9 9 9 4 CLASP N terminal DUF3385 PF11865.8 VDK68634.1 - 9.2e-06 25.7 10.2 3 7.8 0.1 6.6 6 1 0 6 6 6 3 Domain of unknown function (DUF3385) UME PF08064.13 VDK68634.1 - 4.3e-05 23.4 3.8 2.1 8.3 0.1 6.5 6 1 1 7 7 7 2 UME (NUC010) domain Dopey_N PF04118.14 VDK68634.1 - 0.00061 19.0 6.5 0.076 12.1 0.1 4.9 6 0 0 6 6 6 1 Dopey, N-terminal Tti2 PF10521.9 VDK68634.1 - 0.00075 19.1 4.1 1.6 8.2 0.1 4.3 3 1 0 3 3 3 2 Tti2 family DUF937 PF06078.11 VDK68634.1 - 0.0042 17.7 0.4 0.37 11.4 0.0 4.2 4 1 0 4 4 4 1 Bacterial protein of unknown function (DUF937) Adaptin_N PF01602.20 VDK68634.1 - 0.018 13.6 0.0 0.018 13.6 0.0 8.5 7 2 0 8 8 8 0 Adaptin N terminal region Cohesin_HEAT PF12765.7 VDK68634.1 - 0.024 14.9 0.2 61 4.1 0.0 5.7 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion SPG48 PF14764.6 VDK68634.1 - 0.17 12.4 2.8 15 6.1 0.3 4.1 3 0 0 3 3 3 0 AP-5 complex subunit, vesicle trafficking DUF1682 PF07946.14 VDK68635.1 - 2.8e-86 289.7 5.2 3.5e-86 289.4 5.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) MtlR PF05068.12 VDK68635.1 - 0.36 10.8 4.1 0.37 10.8 0.0 2.9 3 1 1 4 4 4 0 Mannitol repressor RPN2_C PF18004.1 VDK68635.1 - 7.3 6.5 20.6 0.18 11.7 12.0 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain SWIB PF02201.18 VDK68636.1 - 2.8e-24 84.8 0.2 7.1e-24 83.5 0.2 1.8 1 0 0 1 1 1 1 SWIB/MDM2 domain Methyltransf_23 PF13489.6 VDK68636.1 - 5.5e-14 52.3 0.1 1.4e-13 51.0 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK68636.1 - 9.1e-12 45.6 0.0 2.5e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK68636.1 - 4.2e-11 43.4 0.0 1.3e-10 41.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK68636.1 - 3.9e-09 37.0 0.0 1.7e-08 35.0 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK68636.1 - 1.3e-07 31.5 0.0 3e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK68636.1 - 1.2e-05 24.9 0.0 2.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 VDK68636.1 - 0.0047 16.3 0.0 0.0083 15.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_4 PF02390.17 VDK68636.1 - 0.037 13.5 0.0 0.2 11.1 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase DUF1018 PF06252.12 VDK68636.1 - 0.065 14.2 0.0 0.21 12.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) DKCLD PF08068.12 VDK68636.1 - 0.071 13.2 0.4 0.23 11.6 0.0 2.1 2 0 0 2 2 2 0 DKCLD (NUC011) domain Rsm22 PF09243.10 VDK68636.1 - 0.082 12.2 0.0 0.23 10.7 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial small ribosomal subunit Rsm22 MRP-L46 PF11788.8 VDK68637.1 - 6.9e-07 30.0 1.8 1e-05 26.3 0.0 2.5 2 1 0 2 2 2 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 VDK68637.1 - 0.1 12.7 0.0 0.34 10.9 0.0 1.9 1 1 0 1 1 1 0 NUDIX domain CUE PF02845.16 VDK68638.1 - 0.11 12.2 0.0 1.8 8.4 0.0 2.4 2 0 0 2 2 2 0 CUE domain VKOR PF07884.14 VDK68641.1 - 1.9e-10 41.0 0.3 2.1e-10 40.9 0.3 1.1 1 0 0 1 1 1 1 Vitamin K epoxide reductase family Tfb4 PF03850.14 VDK68642.1 - 1.6e-55 188.6 5.6 5.1e-48 164.0 1.7 2.0 1 1 1 2 2 2 2 Transcription factor Tfb4 Baculo_IE-1 PF05290.11 VDK68642.1 - 0.066 13.2 3.8 0.62 10.0 3.7 2.2 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) CTD_bind PF04818.13 VDK68644.1 - 9.3e-05 23.2 0.0 0.00022 22.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.8 VDK68644.1 - 0.0017 18.8 1.4 0.0069 16.8 0.1 2.4 2 0 0 2 2 2 1 Subunit of cleavage factor IA Pcf11 zf_UBZ PF18439.1 VDK68644.1 - 0.019 14.6 0.1 0.019 14.6 0.1 1.9 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF2256 PF10013.9 VDK68644.1 - 0.16 12.1 0.6 4.4 7.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF1236 PF06823.12 VDK68644.1 - 0.56 10.1 3.5 1.8 8.5 0.0 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF1236) Zn-C2H2_12 PF18112.1 VDK68644.1 - 0.79 10.2 3.7 2.9 8.4 0.0 2.8 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain DUF4602 PF15375.6 VDK68648.1 - 3.1e-12 47.0 9.6 3.9e-12 46.7 9.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4602) RRM_1 PF00076.22 VDK68651.1 - 1.7e-19 69.4 0.0 2.4e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK68651.1 - 0.058 13.3 0.0 0.11 12.3 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif RRM_3 PF08777.11 VDK68651.1 - 0.058 13.4 0.0 0.096 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Apt1 PF10351.9 VDK68651.1 - 0.13 11.1 10.6 0.14 11.0 10.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 VDK68651.1 - 1.1 8.0 4.4 1.2 7.9 4.4 1.1 1 0 0 1 1 1 0 Presenilin PEHE PF15275.6 VDK68653.1 - 1.4e-07 32.2 3.2 1.4e-07 32.2 3.2 1.6 1 1 1 2 2 2 1 PEHE domain SAS4 PF15460.6 VDK68653.1 - 0.00024 21.2 1.9 0.00024 21.2 1.9 1.7 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 PAN_1 PF00024.26 VDK68658.1 - 5.1e-09 36.0 0.5 8e-09 35.4 0.5 1.3 1 0 0 1 1 1 1 PAN domain PAN_3 PF08277.12 VDK68658.1 - 0.012 15.4 0.3 0.025 14.4 0.3 1.5 1 0 0 1 1 1 0 PAN-like domain PAN_4 PF14295.6 VDK68658.1 - 0.025 14.5 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 PAN domain Kinesin PF00225.23 VDK68660.1 - 5.9e-113 377.2 1.9 5.9e-113 377.2 1.9 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 VDK68660.1 - 3.6e-29 101.6 0.1 3.6e-29 101.6 0.1 2.6 2 1 0 2 2 2 1 Microtubule binding zf-C2H2_4 PF13894.6 VDK68662.1 - 0.039 14.8 9.3 0.57 11.2 0.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK68662.1 - 0.048 14.1 9.6 0.23 12.0 0.1 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf_UBZ PF18439.1 VDK68662.1 - 0.11 12.1 0.5 0.41 10.3 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_3rep PF18868.1 VDK68662.1 - 1.1 9.9 5.5 3.3 8.4 0.1 3.3 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats SBDS_C PF09377.10 VDK68663.1 - 9.1e-33 112.7 0.8 2.8e-32 111.2 0.1 1.9 2 0 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 VDK68663.1 - 1.8e-32 111.2 1.1 3.1e-32 110.5 1.1 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SLS PF14611.6 VDK68663.1 - 0.033 14.0 1.4 0.24 11.2 0.1 2.1 1 1 0 2 2 2 0 Mitochondrial inner-membrane-bound regulator GST_N_3 PF13417.6 VDK68664.1 - 6.4e-20 71.3 0.0 1.3e-19 70.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 VDK68664.1 - 4.5e-16 59.0 0.1 9.1e-16 58.0 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 VDK68664.1 - 3.2e-15 56.2 0.0 6.4e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 VDK68664.1 - 4.1e-06 26.7 0.0 7.2e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 VDK68664.1 - 4.9e-05 23.5 0.0 8.1e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 VDK68664.1 - 0.0025 18.0 0.0 0.0045 17.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 VDK68664.1 - 0.034 14.7 0.0 0.055 14.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 VDK68664.1 - 0.043 14.5 0.0 0.094 13.5 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Glutaredoxin2_C PF04399.13 VDK68664.1 - 0.063 13.1 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Glutaredoxin PF00462.24 VDK68664.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin FAD_binding_2 PF00890.24 VDK68714.1 - 1.6e-30 106.5 0.0 2.6e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 VDK68714.1 - 4.9e-11 42.6 0.1 6.9e-11 42.1 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 VDK68714.1 - 1.2e-07 31.6 0.1 1.8e-07 31.1 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 VDK68714.1 - 9.6e-06 24.9 0.2 1.7e-05 24.1 0.2 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 VDK68714.1 - 4.5e-05 23.6 0.4 0.00011 22.4 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 VDK68714.1 - 4.5e-05 22.8 0.0 6.7e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 VDK68714.1 - 0.00015 20.6 0.0 0.00021 20.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 VDK68714.1 - 0.02 14.2 1.2 0.03 13.6 1.2 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 VDK68714.1 - 0.025 13.8 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 VDK68714.1 - 0.028 13.7 0.1 0.046 13.0 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 VDK68714.1 - 0.1 11.6 0.1 0.16 11.0 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 VDK68714.1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Thi4 family BTG PF07742.12 VDK68716.1 - 8.3e-11 41.8 0.2 5.6e-10 39.1 0.2 2.3 1 1 0 1 1 1 1 BTG family FAD_binding_2 PF00890.24 VDK68719.1 - 2.9e-54 184.7 0.1 3.6e-54 184.4 0.1 1.0 1 0 0 1 1 1 1 FAD binding domain KH_1 PF00013.29 VDK68721.1 - 5.4e-69 227.9 18.9 9.9e-18 63.7 2.2 4.3 4 0 0 4 4 4 4 KH domain DUF1897 PF09005.10 VDK68721.1 - 3.8e-21 74.3 2.4 3.8e-21 74.3 2.4 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1897) KH_2 PF07650.17 VDK68721.1 - 9e-19 67.1 8.2 0.00042 20.1 0.4 4.4 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 VDK68721.1 - 5.4e-10 39.0 10.5 0.049 13.5 0.5 4.5 4 0 0 4 4 4 4 KH domain Epimerase PF01370.21 VDK68722.1 - 2.7e-23 82.7 0.0 3.7e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 VDK68722.1 - 2.1e-16 59.8 0.0 3.1e-16 59.2 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 VDK68722.1 - 3.1e-13 50.0 0.1 4.2e-13 49.6 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 VDK68722.1 - 3.2e-12 46.2 0.2 7.4e-12 45.0 0.2 1.5 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 VDK68722.1 - 6.3e-12 45.5 0.0 7.9e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 VDK68722.1 - 1.1e-06 28.4 0.1 2.5e-06 27.2 0.1 1.6 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 VDK68722.1 - 5.6e-05 22.4 0.1 8.8e-05 21.8 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 VDK68722.1 - 0.0019 17.7 0.2 0.0066 15.9 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase INTS2 PF14750.6 VDK68722.1 - 0.067 10.7 0.0 0.094 10.3 0.0 1.1 1 0 0 1 1 1 0 Integrator complex subunit 2 KR PF08659.10 VDK68722.1 - 0.1 12.5 0.2 9.7 6.1 0.0 2.3 2 0 0 2 2 2 0 KR domain Sep15_SelM PF08806.11 VDK68724.1 - 2e-23 82.4 0.1 4.4e-23 81.2 0.1 1.6 1 0 0 1 1 1 1 Sep15/SelM redox domain Pyr_redox_2 PF07992.14 VDK68725.1 - 5e-65 219.6 0.1 9.4e-65 218.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 VDK68725.1 - 3.4e-36 123.8 0.4 1e-35 122.3 0.4 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 VDK68725.1 - 7.5e-20 71.4 1.0 2.2e-19 69.8 0.3 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Longin PF13774.6 VDK68725.1 - 2.1e-19 69.3 0.1 4.3e-19 68.3 0.1 1.6 1 0 0 1 1 1 1 Regulated-SNARE-like domain Pyr_redox PF00070.27 VDK68725.1 - 2.4e-18 66.5 1.9 7.7e-16 58.4 0.0 3.8 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Synaptobrevin PF00957.21 VDK68725.1 - 1.1e-12 47.6 0.0 2.6e-12 46.4 0.0 1.6 1 0 0 1 1 1 1 Synaptobrevin FAD_oxidored PF12831.7 VDK68725.1 - 1.5e-05 24.5 0.0 2.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 VDK68725.1 - 0.00014 20.7 0.3 0.22 10.2 0.2 2.5 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 VDK68725.1 - 0.0003 20.0 3.0 0.089 11.8 1.0 2.4 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 VDK68725.1 - 0.00032 19.9 2.2 0.0024 17.0 1.0 2.7 4 0 0 4 4 4 1 Glucose inhibited division protein A NAD_binding_7 PF13241.6 VDK68725.1 - 0.0013 19.2 0.0 0.52 10.8 0.0 2.9 3 0 0 3 3 3 1 Putative NAD(P)-binding AlaDh_PNT_C PF01262.21 VDK68725.1 - 0.0058 16.0 0.0 0.77 9.0 0.0 2.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 VDK68725.1 - 0.02 15.1 2.4 0.12 12.6 0.3 2.8 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Sec20 PF03908.13 VDK68725.1 - 0.053 13.4 0.1 0.23 11.4 0.1 2.0 2 0 0 2 2 2 0 Sec20 DAO PF01266.24 VDK68725.1 - 0.14 11.7 6.9 0.38 10.3 0.2 3.0 3 1 0 3 3 3 0 FAD dependent oxidoreductase AAA_12 PF13087.6 VDK68727.1 - 1.1e-31 110.0 0.8 1.6e-30 106.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 VDK68727.1 - 5.4e-24 85.4 0.0 3.4e-22 79.5 0.0 2.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 VDK68727.1 - 3.1e-07 30.8 0.0 0.00015 22.1 0.0 2.8 3 0 0 3 3 3 1 AAA domain UvrD-helicase PF00580.21 VDK68727.1 - 1e-06 28.5 1.8 0.0077 15.8 0.0 3.2 3 1 0 3 3 3 2 UvrD/REP helicase N-terminal domain AAA_30 PF13604.6 VDK68727.1 - 3.9e-06 26.7 0.0 0.00093 19.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 VDK68727.1 - 0.0042 17.4 0.0 0.12 12.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 VDK68727.1 - 0.029 14.8 0.0 0.2 12.1 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 VDK68727.1 - 0.066 13.6 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Mac PF12464.8 VDK68727.1 - 0.12 12.6 0.2 0.55 10.5 0.2 2.2 1 0 0 1 1 1 0 Maltose acetyltransferase COesterase PF00135.28 VDK68728.1 - 3.4e-139 465.0 0.0 4e-139 464.8 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_6 PF12697.7 VDK68728.1 - 0.00017 22.3 0.3 0.00017 22.3 0.3 2.1 3 0 0 3 3 3 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 VDK68728.1 - 0.00027 20.5 0.4 0.00048 19.7 0.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 VDK68728.1 - 0.00034 20.5 0.2 0.0011 18.8 0.2 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ribosomal_L23eN PF03939.13 VDK68729.1 - 7.5e-21 74.1 4.8 7.5e-21 74.1 4.8 1.8 1 1 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 VDK68729.1 - 5.6e-17 61.9 6.2 4.4e-16 59.0 3.1 2.8 2 1 0 2 2 2 1 Ribosomal protein L23 Gemin7 PF11095.8 VDK68730.1 - 1e-25 89.4 0.1 1.2e-25 89.1 0.1 1.1 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) SM-ATX PF14438.6 VDK68730.1 - 0.053 13.7 0.1 0.091 12.9 0.1 1.5 1 1 0 1 1 1 0 Ataxin 2 SM domain PAF-AH_p_II PF03403.13 VDK68731.1 - 1.5e-100 336.3 0.0 2e-100 335.9 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 VDK68731.1 - 5e-12 45.3 0.1 1.4e-10 40.5 0.1 2.1 1 1 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 VDK68731.1 - 3.9e-08 32.7 0.0 0.0061 15.6 0.0 2.3 2 0 0 2 2 2 2 Chlorophyllase DLH PF01738.18 VDK68731.1 - 8.2e-07 28.8 0.0 5.3e-06 26.1 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 VDK68731.1 - 1.4e-05 24.5 0.9 0.00073 18.9 0.0 2.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 VDK68731.1 - 9.9e-05 22.3 0.0 0.0066 16.3 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 VDK68731.1 - 0.0015 18.4 0.1 0.0054 16.6 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 VDK68731.1 - 0.0027 17.7 0.0 0.0058 16.6 0.0 1.5 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 VDK68731.1 - 0.0027 18.3 0.0 0.0052 17.4 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 VDK68731.1 - 0.0028 17.5 0.1 0.0053 16.6 0.1 1.5 1 0 0 1 1 1 1 Lipase (class 3) AXE1 PF05448.12 VDK68731.1 - 0.0051 15.5 0.1 0.028 13.1 0.0 2.0 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 VDK68731.1 - 0.0096 15.4 0.1 0.045 13.2 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 VDK68731.1 - 0.013 15.2 0.5 0.032 13.9 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 VDK68731.1 - 0.093 12.5 0.0 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF2974 PF11187.8 VDK68731.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) zf-AN1 PF01428.16 VDK68732.1 - 9.7e-06 25.6 6.9 9.7e-06 25.6 6.9 2.1 2 0 0 2 2 2 1 AN1-like Zinc finger ubiquitin PF00240.23 VDK68732.1 - 0.00012 21.8 0.0 0.00033 20.3 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family FYVE PF01363.21 VDK68732.1 - 0.027 14.6 3.6 0.027 14.6 3.6 2.4 2 0 0 2 2 2 0 FYVE zinc finger tRNA_m1G_MT PF01746.21 VDK68733.1 - 4.8e-22 78.6 0.0 7.4e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase RNase_P_p30 PF01876.16 VDK68735.1 - 1.2e-36 126.2 0.1 2.4e-36 125.2 0.1 1.5 1 1 0 1 1 1 1 RNase P subunit p30 CS PF04969.16 VDK68737.1 - 7.3e-12 46.1 0.2 3e-11 44.2 0.0 2.2 2 0 0 2 2 2 1 CS domain TAF PF02969.17 VDK68743.1 - 0.001 19.2 0.2 1.1 9.5 0.1 2.4 2 0 0 2 2 2 2 TATA box binding protein associated factor (TAF) VPS9 PF02204.18 VDK68744.1 - 4e-25 88.0 0.0 1.2e-24 86.5 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RasGAP PF00616.19 VDK68744.1 - 3.5e-15 56.3 0.0 9.6e-15 54.8 0.0 1.8 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Rrf2 PF02082.20 VDK68744.1 - 0.04 14.3 0.0 0.15 12.4 0.0 2.0 1 0 0 1 1 1 0 Transcriptional regulator DUF5601 PF18151.1 VDK68744.1 - 0.096 13.0 0.1 0.4 11.0 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) Cnd1 PF12717.7 VDK68744.1 - 0.5 10.4 2.6 7.7 6.5 0.1 3.2 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Complex1_51K PF01512.17 VDK68745.1 - 1.6e-49 167.6 0.0 2.6e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 VDK68745.1 - 3.8e-29 100.6 0.1 7.4e-29 99.7 0.1 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 VDK68745.1 - 1.6e-06 27.9 0.0 2.8e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 SLBB domain HEAT PF02985.22 VDK68746.1 - 6.1e-47 153.6 23.2 0.00049 20.1 0.0 13.5 14 0 0 14 14 14 12 HEAT repeat HEAT_2 PF13646.6 VDK68746.1 - 1e-35 122.0 11.5 1.5e-07 31.7 0.1 8.7 2 1 9 11 11 11 10 HEAT repeats Vac14_Fab1_bd PF12755.7 VDK68746.1 - 6.2e-16 58.8 3.8 4.7e-05 23.9 0.0 7.9 3 1 7 10 10 10 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 VDK68746.1 - 4.3e-12 46.4 12.3 0.0015 18.6 0.1 5.8 2 1 4 6 6 6 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 VDK68746.1 - 6.8e-10 38.1 2.1 0.00023 19.9 0.0 3.2 1 1 1 2 2 2 2 Adaptin N terminal region CLASP_N PF12348.8 VDK68746.1 - 5.9e-09 35.8 1.8 0.0014 18.2 0.1 4.8 1 1 4 6 6 6 3 CLASP N terminal HEAT_EZ PF13513.6 VDK68746.1 - 4.6e-05 23.8 15.5 7.2 7.2 0.1 9.4 10 3 1 11 11 11 1 HEAT-like repeat Ecm29 PF13001.7 VDK68746.1 - 5.1e-05 22.1 1.2 1 8.0 0.1 3.7 4 0 0 4 4 4 3 Proteasome stabiliser TAF6_C PF07571.13 VDK68746.1 - 8.5e-05 22.8 0.1 3 8.2 0.0 4.8 3 2 1 4 4 4 1 TAF6 C-terminal HEAT repeat domain Nipped-B_C PF12830.7 VDK68746.1 - 0.0028 17.6 0.2 2.9 7.8 0.0 3.3 3 0 0 3 3 3 2 Sister chromatid cohesion C-terminus HEAT_PBS PF03130.16 VDK68746.1 - 0.04 14.6 1.0 63 4.7 0.0 5.1 6 0 0 6 6 4 0 PBS lyase HEAT-like repeat IFRD PF05004.13 VDK68746.1 - 0.086 11.9 7.4 0.83 8.7 0.1 4.3 3 1 1 5 5 5 0 Interferon-related developmental regulator (IFRD) UNC45-central PF11701.8 VDK68746.1 - 0.088 12.8 2.6 5.4 7.0 1.7 3.1 2 1 1 3 3 3 0 Myosin-binding striated muscle assembly central Pkinase PF00069.25 VDK68748.1 - 2.7e-68 230.2 0.0 3.4e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK68748.1 - 1.7e-27 96.3 0.1 7.5e-27 94.2 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK68748.1 - 0.0027 17.1 1.7 1.2 8.4 0.1 2.4 1 1 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 VDK68748.1 - 0.0031 16.5 0.1 0.27 10.1 0.1 2.2 2 0 0 2 2 2 2 Haspin like kinase domain DEAD PF00270.29 VDK68749.1 - 8.4e-35 120.1 0.0 1.4e-34 119.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK68749.1 - 7.1e-30 103.6 0.9 1.7e-29 102.4 0.4 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK68749.1 - 9.9e-06 25.7 0.0 5.5e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Proteasome PF00227.26 VDK68750.1 - 1.5e-36 125.7 0.0 1.8e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Sad1_UNC PF07738.13 VDK68751.1 - 1.9e-28 99.1 0.0 3.9e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Fer4_5 PF12801.7 VDK68752.1 - 0.48 10.4 9.6 0.3 11.1 7.5 1.8 1 1 0 1 1 1 0 4Fe-4S binding domain M_domain PF12938.7 VDK68754.1 - 0.003 17.4 0.2 0.003 17.4 0.2 2.1 2 0 0 2 2 2 1 M domain of GW182 WD40 PF00400.32 VDK68755.1 - 3.6e-31 106.7 20.0 1e-06 29.3 0.6 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat Beta-TrCP_D PF12125.8 VDK68755.1 - 4.1e-18 65.0 0.3 1e-17 63.7 0.3 1.7 1 0 0 1 1 1 1 D domain of beta-TrCP ANAPC4_WD40 PF12894.7 VDK68755.1 - 3.6e-08 33.6 0.3 0.0018 18.5 0.1 3.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 VDK68755.1 - 1.7e-06 27.8 1.2 3.4e-06 26.8 1.2 1.6 1 0 0 1 1 1 1 F-box-like WD40_like PF17005.5 VDK68755.1 - 0.0049 16.2 0.1 1 8.6 0.1 2.8 2 1 1 3 3 3 2 WD40-like domain F-box PF00646.33 VDK68755.1 - 0.0094 15.8 1.1 0.032 14.1 1.1 2.0 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 VDK68755.1 - 0.039 12.6 2.5 2.2 6.8 0.1 3.3 2 2 1 4 4 4 0 Nucleoporin Nup120/160 HA2 PF04408.23 VDK68756.1 - 3e-12 46.8 0.0 8.2e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 VDK68756.1 - 1.7e-11 44.4 0.0 6.3e-11 42.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain IBR PF01485.21 VDK68756.1 - 2.9e-11 43.4 20.7 2.2e-09 37.4 7.5 5.0 5 1 0 5 5 5 2 IBR domain, a half RING-finger domain OB_NTP_bind PF07717.16 VDK68756.1 - 2.9e-09 37.2 0.0 1.1e-08 35.3 0.0 2.1 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 VDK68756.1 - 7e-09 35.7 1.2 2.3e-08 34.0 0.2 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK68756.1 - 9.6e-05 22.5 0.0 0.00024 21.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RRM_1 PF00076.22 VDK68756.1 - 0.00032 20.5 0.7 0.0015 18.3 0.2 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_22 PF13401.6 VDK68756.1 - 0.0011 19.3 0.0 0.0058 16.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain SLS PF14611.6 VDK68756.1 - 0.033 14.0 0.0 1.5 8.6 0.0 2.7 1 1 1 2 2 2 0 Mitochondrial inner-membrane-bound regulator ERCC3_RAD25_C PF16203.5 VDK68756.1 - 0.077 12.2 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Ribosomal_S9 PF00380.19 VDK68757.1 - 2.4e-35 121.7 0.5 3e-35 121.4 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 OSTbeta PF15048.6 VDK68757.1 - 0.042 14.0 0.2 0.12 12.5 0.1 1.7 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein F-box PF00646.33 VDK68758.1 - 0.0018 18.1 3.1 0.0029 17.4 0.1 2.8 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 VDK68758.1 - 0.0043 16.9 0.1 0.017 15.0 0.1 2.1 1 0 0 1 1 1 1 F-box-like VPS13_C PF16909.5 VDK68816.1 - 1.3e-56 191.2 9.7 1.1e-55 188.2 0.6 3.8 2 2 1 4 4 4 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 VDK68816.1 - 3.9e-23 82.2 0.0 5.4e-18 65.3 0.0 3.2 3 0 0 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 VDK68816.1 - 8.4e-08 32.5 0.1 3.1e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain HECT PF00632.25 VDK68818.1 - 1.5e-94 317.0 0.1 1.9e-94 316.6 0.1 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 VDK68818.1 - 3.3e-48 161.4 25.9 1.4e-13 50.6 1.3 5.0 5 0 0 5 5 5 4 WW domain C2 PF00168.30 VDK68818.1 - 6e-13 49.0 0.1 1.3e-12 47.9 0.1 1.5 1 0 0 1 1 1 1 C2 domain DHHC PF01529.20 VDK68820.1 - 6.1e-36 123.5 3.3 6.1e-36 123.5 3.3 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Forkhead PF00250.18 VDK68826.1 - 6.3e-13 48.8 0.0 1e-12 48.2 0.0 1.2 1 0 0 1 1 1 1 Forkhead domain DNA_pol_viral_N PF00242.17 VDK68826.1 - 0.072 12.6 1.1 0.087 12.3 1.1 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain Forkhead PF00250.18 VDK68828.1 - 2.4e-22 79.0 0.2 7.7e-22 77.4 0.2 1.8 1 0 0 1 1 1 1 Forkhead domain Pkinase PF00069.25 VDK68829.1 - 1.2e-75 254.3 0.0 1.7e-75 253.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK68829.1 - 2.9e-45 154.6 0.0 4.4e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 VDK68829.1 - 3.8e-14 53.1 0.0 2.1e-13 50.8 0.0 2.3 2 0 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 VDK68829.1 - 2.7e-08 33.5 0.0 4.2e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 VDK68829.1 - 0.00092 18.9 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 VDK68829.1 - 0.0098 14.9 1.1 0.1 11.6 0.1 2.3 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 VDK68829.1 - 0.011 15.7 0.3 0.025 14.5 0.2 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 VDK68829.1 - 0.061 12.7 0.0 0.16 11.3 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family HNF-1_N PF04814.13 VDK68830.1 - 4.6e-14 53.5 4.2 7.7e-14 52.8 0.1 2.9 2 2 0 2 2 2 1 Hepatocyte nuclear factor 1 (HNF-1), N terminus Homeodomain PF00046.29 VDK68830.1 - 2.4e-07 30.5 0.1 1.2e-06 28.3 0.1 2.2 1 1 0 1 1 1 1 Homeodomain HTH_37 PF13744.6 VDK68830.1 - 4.6e-05 23.3 0.0 0.00012 22.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 VDK68830.1 - 0.00011 22.1 0.0 0.00075 19.5 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix Homeobox_KN PF05920.11 VDK68830.1 - 0.0054 16.6 0.2 0.076 12.9 0.0 2.6 2 0 0 2 2 2 1 Homeobox KN domain HTH_31 PF13560.6 VDK68830.1 - 0.0066 16.8 0.0 0.024 15.0 0.0 2.1 1 1 0 1 1 1 1 Helix-turn-helix domain DUF473 PF04322.12 VDK68830.1 - 0.024 14.5 0.0 0.066 13.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF473) HTH_19 PF12844.7 VDK68830.1 - 0.051 13.6 0.1 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Arnt_C PF18583.1 VDK68830.1 - 0.18 11.4 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 Aminoarabinose transferase C-terminal domain KNOX2 PF03791.13 VDK68830.1 - 5.6 6.6 5.4 26 4.4 0.6 3.3 4 0 0 4 4 4 0 KNOX2 domain DC_STAMP PF07782.13 VDK68831.1 - 4.5e-39 134.2 0.4 6.2e-39 133.8 0.4 1.1 1 0 0 1 1 1 1 DC-STAMP-like protein HypA PF01155.19 VDK68831.1 - 2.9 7.9 6.8 9.1 6.3 6.8 1.8 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF86 PF01934.17 VDK68832.1 - 0.028 14.3 0.1 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF86 UPF0172 PF03665.13 VDK68833.1 - 2.6e-43 148.3 0.0 9.6e-43 146.5 0.0 2.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Ank_4 PF13637.6 VDK68833.1 - 4e-20 71.9 1.9 4e-13 49.6 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK68833.1 - 3.1e-19 69.3 0.1 6.7e-14 52.2 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 VDK68833.1 - 6.4e-17 61.2 2.3 7.9e-06 26.1 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 VDK68833.1 - 5.6e-15 53.9 0.2 3e-06 27.1 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 VDK68833.1 - 2.4e-13 50.0 1.4 1.4e-07 31.6 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) PX PF00787.24 VDK68835.1 - 1.9e-18 66.5 0.0 3.7e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 PX domain PDZ PF00595.24 VDK68835.1 - 8.7e-16 58.0 0.7 8.7e-16 58.0 0.7 1.7 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 VDK68835.1 - 1.4e-13 50.4 0.9 1.4e-13 50.4 0.9 2.3 3 0 0 3 3 3 1 PDZ domain RA PF00788.23 VDK68835.1 - 5.6e-06 26.9 0.0 1.2e-05 25.9 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PDZ_2 PF13180.6 VDK68835.1 - 4e-05 23.8 1.2 5.8e-05 23.3 0.1 1.8 2 0 0 2 2 2 1 PDZ domain SNX17_FERM_C PF18116.1 VDK68835.1 - 0.00012 22.1 0.0 0.00029 20.9 0.0 1.7 1 0 0 1 1 1 1 Sorting Nexin 17 FERM C-terminal domain LIM PF00412.22 VDK68836.1 - 7.5e-07 29.3 0.1 9.6e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 LIM domain NDK PF00334.19 VDK68837.1 - 1.7e-56 190.0 0.0 2.2e-56 189.6 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PSI_PsaJ PF01701.18 VDK68837.1 - 0.017 15.6 0.0 0.031 14.8 0.0 1.4 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IX / PsaJ DUF1803 PF08820.10 VDK68837.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) Proton_antipo_C PF01010.19 VDK68839.1 - 0.071 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus LAP1C PF05609.12 VDK68839.1 - 5.7 5.9 17.4 9.6 5.2 17.4 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) IPK PF03770.16 VDK68840.1 - 3.1e-31 108.8 0.2 1.3e-30 106.7 0.2 1.8 1 1 0 1 1 1 1 Inositol polyphosphate kinase PDZ PF00595.24 VDK68841.1 - 2.2e-15 56.8 0.3 4.3e-15 55.8 0.3 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK68841.1 - 5.8e-09 35.7 0.0 1.1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK68841.1 - 0.00047 20.4 0.0 0.00097 19.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain kleA_kleC PF17383.2 VDK68841.1 - 1.6 9.1 4.2 6.2 7.2 0.3 2.8 1 1 2 3 3 3 0 Uncharacterized KorC regulated protein A Fzo_mitofusin PF04799.13 VDK68841.1 - 1.9 8.0 6.9 2.6 7.6 0.5 2.3 1 1 1 2 2 2 0 fzo-like conserved region CENP-H PF05837.12 VDK68841.1 - 4.1 7.9 15.8 1.2 9.6 9.1 3.0 2 1 1 3 3 3 0 Centromere protein H (CENP-H) FAM91_N PF14647.6 VDK68842.1 - 2.8e-128 427.6 5.3 4.3e-128 427.0 5.3 1.3 1 0 0 1 1 1 1 FAM91 N-terminus FAM91_C PF14648.6 VDK68842.1 - 5.4e-100 335.2 1.1 1.9e-72 244.5 0.2 2.4 1 1 1 2 2 2 2 FAM91 C-terminus BTB PF00651.31 VDK68842.1 - 1.5e-20 73.5 1.5 6.9e-11 42.4 0.1 3.6 2 1 0 2 2 2 2 BTB/POZ domain zf-H2C2_2 PF13465.6 VDK68842.1 - 5.4e-18 64.5 20.9 1e-06 28.9 0.3 4.7 4 0 0 4 4 4 4 Zinc-finger double domain zf-H2C2_5 PF13909.6 VDK68842.1 - 2e-09 37.0 11.6 1.5e-05 24.6 2.8 3.6 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 VDK68842.1 - 3.4e-07 30.4 26.5 5.7e-06 26.5 0.7 4.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK68842.1 - 2.2e-06 28.0 26.0 0.0043 17.8 0.6 5.4 5 0 0 5 5 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 VDK68842.1 - 0.0044 17.3 20.0 0.013 15.8 7.7 3.6 2 1 1 3 3 3 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 VDK68842.1 - 0.19 12.1 14.9 0.63 10.4 10.1 3.9 3 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 VDK68842.1 - 0.21 11.7 7.1 3.7 7.6 2.2 2.7 1 1 1 2 2 2 0 BED zinc finger Zn-ribbon_8 PF09723.10 VDK68842.1 - 4.7 7.4 8.1 1.1 9.5 1.6 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Elf1 PF05129.13 VDK68842.1 - 5.9 7.0 13.9 14 5.8 5.4 2.9 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_15 PF17032.5 VDK68842.1 - 8.1 7.3 10.6 13 6.6 8.5 2.6 2 1 0 2 2 1 0 zinc-ribbon family PRELI PF04707.14 VDK68843.1 - 1.7e-45 154.7 0.0 2.1e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family His_Phos_2 PF00328.22 VDK68845.1 - 8e-20 71.5 0.5 2e-14 53.7 0.5 3.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MOLO1 PF17175.4 VDK68847.1 - 2.3e-08 34.2 0.4 3.5e-08 33.6 0.4 1.3 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 FAM163 PF15069.6 VDK68847.1 - 0.12 12.9 0.8 0.24 11.8 0.8 1.5 1 0 0 1 1 1 0 FAM163 family TPM_phosphatase PF04536.14 VDK68847.1 - 0.19 11.9 0.7 0.53 10.4 0.1 1.9 2 0 0 2 2 2 0 TPM domain MIR PF02815.19 VDK68848.1 - 4.4e-14 52.7 0.2 5.7e-13 49.1 0.2 2.3 1 1 2 3 3 3 2 MIR domain JAB PF01398.21 VDK68850.1 - 2e-15 56.8 0.0 4.3e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Syntaxin-6_N PF09177.11 VDK68850.1 - 0.031 14.8 0.1 0.081 13.5 0.1 1.7 1 1 0 1 1 1 0 Syntaxin 6, N-terminal EF-hand_1 PF00036.32 VDK68874.1 - 6.6e-25 84.8 7.8 2.4e-07 29.8 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 VDK68874.1 - 1.7e-24 86.1 10.6 1.6e-13 50.9 0.6 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 VDK68874.1 - 1.3e-22 77.8 4.5 2.1e-06 27.2 0.0 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 VDK68874.1 - 4e-18 65.0 11.7 1.9e-07 30.8 0.5 4.2 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_5 PF13202.6 VDK68874.1 - 1.1e-14 53.2 6.3 0.00016 21.0 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 VDK68874.1 - 1.9e-12 47.3 0.1 2.7e-05 24.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 VDK68874.1 - 1.6e-08 34.4 1.7 7e-05 22.7 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand GatB_Yqey PF02637.18 VDK68874.1 - 0.014 15.2 0.2 0.27 11.1 0.1 2.1 2 0 0 2 2 2 0 GatB domain Caleosin PF05042.13 VDK68874.1 - 0.023 14.6 1.8 2.7 7.9 0.1 3.2 2 1 1 3 3 3 0 Caleosin related protein EF-hand_11 PF08976.11 VDK68874.1 - 0.026 15.4 0.1 2 9.3 0.0 2.3 1 1 1 2 2 2 0 EF-hand domain Endotoxin_C2 PF18449.1 VDK68874.1 - 0.063 13.6 0.1 0.32 11.3 0.0 2.1 2 0 0 2 2 2 0 Delta endotoxin T3RM_EcoP15I_C PF18273.1 VDK68874.1 - 0.069 13.5 0.3 0.42 10.9 0.1 2.2 1 1 1 2 2 2 0 Type III R-M EcoP15I C-terminal domain DUF615 PF04751.14 VDK68874.1 - 0.076 13.0 0.4 0.21 11.6 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF615) dCache_2 PF08269.11 VDK68874.1 - 0.16 11.1 1.4 10 5.2 0.4 2.2 1 1 1 2 2 2 0 Cache domain HTH_Tnp_Tc5 PF03221.16 VDK68876.1 - 3.9e-27 94.1 5.0 2.6e-13 49.8 0.4 2.8 2 0 0 2 2 2 2 Tc5 transposase DNA-binding domain BrkDBD PF09607.10 VDK68876.1 - 0.00059 19.6 0.2 0.00059 19.6 0.2 2.2 2 0 0 2 2 2 1 Brinker DNA-binding domain HTH_Tnp_1 PF01527.20 VDK68876.1 - 0.0072 16.6 0.1 0.041 14.2 0.0 2.3 2 0 0 2 2 2 1 Transposase PapB PF03333.13 VDK68876.1 - 0.1 12.6 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 Adhesin biosynthesis transcription regulatory protein HTH_23 PF13384.6 VDK68876.1 - 0.25 11.2 1.0 15 5.5 0.1 2.9 3 0 0 3 3 3 0 Homeodomain-like domain Arm PF00514.23 VDK68878.1 - 0.00022 21.2 6.0 1.3 9.2 0.1 4.7 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat APC_rep PF18797.1 VDK68878.1 - 0.0013 19.6 0.1 0.0061 17.5 0.1 2.3 1 0 0 1 1 1 1 Adenomatous polyposis coli (APC) repeat Ras PF00071.22 VDK68883.1 - 1.4e-54 184.1 0.8 1.7e-54 183.8 0.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK68883.1 - 7.9e-26 90.6 0.7 1.4e-25 89.8 0.5 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK68883.1 - 5.6e-10 38.9 0.3 8e-10 38.4 0.3 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK68883.1 - 0.00048 19.7 0.1 0.00082 19.0 0.1 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 VDK68883.1 - 0.053 12.9 0.1 0.066 12.6 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF3963 PF13124.6 VDK68883.1 - 0.23 11.4 1.0 0.35 10.9 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3963) LSDAT_euk PF18139.1 VDK68885.1 - 2.9e-107 358.0 0.0 1.1e-105 352.9 0.0 2.3 2 0 0 2 2 2 1 SLOG in TRPM LSDAT_prok PF18171.1 VDK68885.1 - 3.1e-18 65.7 0.1 6e-18 64.8 0.1 1.4 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote Ion_trans PF00520.31 VDK68885.1 - 1e-09 38.0 13.7 1.7e-09 37.3 13.7 1.2 1 0 0 1 1 1 1 Ion transport protein PAP_assoc PF03828.19 VDK68888.1 - 1.2e-13 51.0 0.0 6.8e-13 48.6 0.0 2.2 2 0 0 2 2 2 1 Cid1 family poly A polymerase CK_II_beta PF01214.18 VDK68889.1 - 4.9e-81 270.9 0.0 6e-81 270.6 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit UCH PF00443.29 VDK68890.1 - 2.2e-45 155.2 0.0 8.8e-45 153.2 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase OTU PF02338.19 VDK68890.1 - 1.3e-06 28.9 0.0 3.9e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease UCH_1 PF13423.6 VDK68890.1 - 1.7e-06 27.9 17.6 0.67 9.5 17.6 4.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C65 PF10275.9 VDK68890.1 - 0.058 12.8 0.0 0.16 11.4 0.0 1.7 1 0 0 1 1 1 0 Peptidase C65 Otubain Pterin_4a PF01329.19 VDK68893.1 - 5.7e-31 106.6 0.0 8.9e-31 105.9 0.0 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Snf7 PF03357.21 VDK68894.1 - 1.3e-25 90.0 9.5 2.1e-25 89.3 9.5 1.3 1 0 0 1 1 1 1 Snf7 GUCT PF08152.12 VDK68894.1 - 0.038 14.3 0.1 0.069 13.5 0.1 1.5 1 0 0 1 1 1 0 GUCT (NUC152) domain DUF5624 PF18538.1 VDK68894.1 - 0.046 13.8 0.4 0.068 13.3 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) DUF3585 PF12130.8 VDK68894.1 - 0.078 13.1 7.3 0.13 12.3 7.3 1.4 1 0 0 1 1 1 0 Bivalent Mical/EHBP Rab binding domain E2_bind PF08825.10 VDK68894.1 - 0.086 13.0 0.2 0.086 13.0 0.2 3.0 2 1 1 3 3 3 0 E2 binding domain DASH_Dad3 PF08656.10 VDK68894.1 - 5.9 7.1 7.7 4.1e+02 1.1 7.7 2.7 1 1 0 1 1 1 0 DASH complex subunit Dad3 RRM_1 PF00076.22 VDK68895.1 - 5.3e-16 58.2 0.0 8.8e-16 57.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAGA-Tad1 PF12767.7 VDK68895.1 - 0.025 14.3 0.1 0.031 14.0 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit WD40 PF00400.32 VDK68896.1 - 1.3e-20 73.3 11.7 0.00016 22.4 0.5 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat PQQ_3 PF13570.6 VDK68896.1 - 0.013 16.0 0.1 7 7.3 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain ANAPC4_WD40 PF12894.7 VDK68896.1 - 0.038 14.3 0.0 26 5.2 0.0 3.6 2 2 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 VDK68896.1 - 0.043 12.6 0.8 0.59 8.8 0.1 2.8 1 1 1 2 2 2 0 Nup133 N terminal like WD40_like PF17005.5 VDK68896.1 - 0.045 13.1 0.0 3.1 7.0 0.0 2.7 2 1 0 2 2 2 0 WD40-like domain Sod_Fe_C PF02777.18 VDK68897.1 - 2.5e-33 114.3 0.0 4.4e-33 113.5 0.0 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 VDK68897.1 - 1.7e-29 102.1 0.6 2.6e-29 101.5 0.6 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain TH1 PF04858.13 VDK68898.1 - 1.6e-151 505.8 1.5 1.9e-151 505.6 1.5 1.0 1 0 0 1 1 1 1 TH1 protein FHA PF00498.26 VDK68899.1 - 4.6e-14 52.5 0.0 9.2e-14 51.6 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 VDK68899.1 - 8.9e-06 25.9 0.0 1.5e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain UMPH-1 PF05822.12 VDK68900.1 - 7e-82 274.6 0.1 8.6e-82 274.4 0.1 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 VDK68900.1 - 0.00011 22.6 0.0 0.00021 21.8 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase zf-CCCH PF00642.24 VDK68901.1 - 7.2e-11 41.7 14.0 1.1e-05 25.2 1.6 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 VDK68901.1 - 9.1e-06 26.3 3.0 0.014 16.1 0.1 2.4 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 VDK68901.1 - 3.9e-05 23.6 19.4 0.0062 16.6 4.7 2.9 3 0 0 3 3 3 2 Zinc finger domain RRM_1 PF00076.22 VDK68901.1 - 6.8e-05 22.6 0.1 0.00014 21.6 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_3 PF15663.5 VDK68901.1 - 0.053 13.8 4.0 1.7 8.9 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger containing family Nup35_RRM_2 PF14605.6 VDK68901.1 - 0.076 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif GRP PF07172.11 VDK68901.1 - 5.3 7.8 19.7 12 6.7 19.7 1.5 1 0 0 1 1 1 0 Glycine rich protein family Gal-bind_lectin PF00337.22 VDK68903.1 - 1.3e-54 183.3 0.0 1.3e-30 105.7 0.0 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin MPP6 PF10175.9 VDK68905.1 - 1.7e-10 41.5 9.8 2.8e-10 40.8 9.8 1.4 1 1 0 1 1 1 1 M-phase phosphoprotein 6 DUF4692 PF15763.5 VDK68905.1 - 0.18 12.3 1.2 0.55 10.7 1.1 1.8 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) MPC PF03650.13 VDK68906.1 - 3.4e-38 130.2 0.2 3.8e-38 130.0 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MtN3_slv PF03083.16 VDK68906.1 - 0.015 15.3 0.6 0.025 14.6 0.6 1.4 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange MPC PF03650.13 VDK68907.1 - 1.8e-40 137.5 1.0 2.1e-40 137.3 1.0 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MtN3_slv PF03083.16 VDK68907.1 - 0.065 13.3 1.1 0.11 12.5 1.1 1.5 1 1 0 1 1 1 0 Sugar efflux transporter for intercellular exchange Ras PF00071.22 VDK68909.1 - 1.1e-62 210.4 0.1 1.4e-62 210.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK68909.1 - 4.1e-33 114.1 0.1 1e-32 112.9 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK68909.1 - 5.5e-13 48.8 0.0 6.8e-13 48.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK68909.1 - 5.6e-05 23.2 0.0 9e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK68909.1 - 0.00015 21.2 0.0 0.00021 20.7 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 VDK68909.1 - 0.00058 19.8 0.1 0.27 11.1 0.0 2.5 1 1 2 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 VDK68909.1 - 0.0012 18.4 0.1 0.0048 16.5 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 VDK68909.1 - 0.021 14.5 0.1 0.053 13.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK68909.1 - 0.022 15.0 0.1 0.2 12.0 0.1 2.4 1 1 1 2 2 2 0 AAA domain DAP3 PF10236.9 VDK68909.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 TetR_C_16 PF17920.1 VDK68909.1 - 0.17 12.1 0.0 0.3 11.3 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Na_K-ATPase PF00287.18 VDK68911.1 - 2.7e-23 82.6 3.9 4.1e-23 82.0 3.9 1.3 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain 7tm_3 PF00003.22 VDK68913.1 - 3.5e-53 180.8 26.4 6.4e-53 179.9 26.4 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 VDK68913.1 - 1.6e-38 132.7 0.0 2.1e-38 132.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region DUF2976 PF11190.8 VDK68913.1 - 0.0096 15.7 9.5 0.065 13.0 2.5 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF2976) ATP-synt_8 PF00895.20 VDK68913.1 - 1.2 9.6 3.6 12 6.5 0.6 2.8 2 0 0 2 2 2 0 ATP synthase protein 8 PI3_PI4_kinase PF00454.27 VDK68914.1 - 1.3e-54 185.7 0.0 2.8e-54 184.6 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SMG1 PF15785.5 VDK68914.1 - 1.3e-54 185.7 12.3 1.2e-23 83.4 1.2 4.2 3 1 0 3 3 3 3 Serine/threonine-protein kinase smg-1 DUF4795 PF16043.5 VDK68914.1 - 0.56 9.8 5.2 6.8 6.2 3.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Dynamitin PF04912.14 VDK68974.1 - 3.6e-58 197.8 9.9 7e-31 107.9 3.6 2.0 1 1 1 2 2 2 2 Dynamitin DUF1572 PF07609.11 VDK68974.1 - 0.019 14.7 0.1 0.042 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1572) Laminin_II PF06009.12 VDK68974.1 - 0.052 13.6 5.3 2.2 8.3 0.3 3.6 3 2 0 3 3 3 0 Laminin Domain II Phage_GPO PF05929.11 VDK68974.1 - 0.086 12.4 2.2 3.6 7.1 1.3 2.2 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase YvrJ PF12841.7 VDK68974.1 - 0.14 11.7 3.4 12 5.5 0.0 3.9 4 0 0 4 4 4 0 YvrJ protein family V-SNARE PF05008.15 VDK68974.1 - 0.2 12.1 0.2 0.2 12.1 0.2 2.9 4 1 0 4 4 4 0 Vesicle transport v-SNARE protein N-terminus SLATT_1 PF18181.1 VDK68974.1 - 0.29 11.1 1.7 2 8.4 0.1 2.5 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 BLOC1_2 PF10046.9 VDK68974.1 - 0.31 11.4 10.1 2.2 8.7 1.0 4.3 2 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MerR-DNA-bind PF09278.11 VDK68974.1 - 0.89 10.1 0.0 0.89 10.1 0.0 4.1 5 0 0 5 5 5 0 MerR, DNA binding LPP PF04728.13 VDK68974.1 - 1.2 9.6 4.8 25 5.3 0.2 4.2 4 0 0 4 4 4 0 Lipoprotein leucine-zipper DUF724 PF05266.14 VDK68974.1 - 7.5 6.3 12.5 1 9.1 0.2 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF724) STAT_alpha PF01017.20 VDK68974.1 - 7.6 6.4 10.1 2.5 8.0 1.9 3.2 3 1 1 4 4 4 0 STAT protein, all-alpha domain Glycos_transf_2 PF00535.26 VDK68976.1 - 3.6e-34 118.0 0.0 7.1e-34 117.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 VDK68976.1 - 2.8e-25 89.0 6.7 1.6e-23 83.3 4.9 2.2 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 VDK68976.1 - 0.00042 21.0 2.2 1.4 9.7 0.6 2.6 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like Glyco_transf_7C PF02709.14 VDK68976.1 - 0.0007 19.2 0.4 0.0021 17.7 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase CDtoxinA PF03498.14 VDK68976.1 - 0.0016 18.1 0.3 0.0047 16.5 0.1 1.8 1 1 0 1 1 1 1 Cytolethal distending toxin A/C domain Mito_carr PF00153.27 VDK68977.1 - 6.5e-47 157.4 6.0 4.1e-18 65.1 0.3 4.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 VDK68977.1 - 0.00014 21.1 0.1 0.00034 19.9 0.1 1.7 1 1 0 1 1 1 1 Gammaproteobacterial serine protease PI-PLC-X PF00388.19 VDK68979.1 - 8e-08 32.0 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Tho2 PF11262.8 VDK68981.1 - 2.7e-82 276.4 4.0 2.7e-82 276.4 4.0 2.3 3 0 0 3 3 3 1 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 VDK68981.1 - 2.5e-62 211.4 14.8 4.5e-42 144.5 1.3 3.2 3 1 0 3 3 3 2 THO complex subunit 2 N-terminus Thoc2 PF11732.8 VDK68981.1 - 3.5e-29 100.7 0.0 1.7e-28 98.4 0.0 2.3 1 0 0 1 1 1 1 Transcription- and export-related complex subunit PAN_1 PF00024.26 VDK68982.1 - 0.00036 20.4 0.9 0.00062 19.7 0.9 1.4 1 0 0 1 1 1 1 PAN domain SH3_9 PF14604.6 VDK68983.1 - 2.4e-14 52.9 0.2 4.2e-14 52.1 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain Cofilin_ADF PF00241.20 VDK68983.1 - 1e-13 51.1 0.0 2.9e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 VDK68983.1 - 1.1e-12 47.3 0.4 3e-12 45.9 0.4 1.8 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK68983.1 - 4e-10 39.2 0.0 1.4e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain BPL_N PF09825.9 VDK68983.1 - 2.4 7.1 9.3 3.6 6.6 9.3 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DER1 PF04511.15 VDK68984.1 - 1.1e-45 155.9 8.4 1.3e-45 155.7 8.4 1.0 1 0 0 1 1 1 1 Der1-like family HSP90 PF00183.18 VDK68985.1 - 5.4e-89 299.4 5.6 5.1e-87 292.9 1.0 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 VDK68985.1 - 6.1e-14 52.0 0.3 1.2e-13 51.0 0.3 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 VDK68985.1 - 1e-08 35.7 0.1 2e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF759 PF05537.11 VDK68986.1 - 0.15 10.9 0.6 0.24 10.3 0.0 1.5 2 0 0 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF759) DEAD PF00270.29 VDK68987.1 - 3e-45 154.2 0.0 8e-45 152.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK68987.1 - 1.1e-26 93.3 0.0 1.3e-25 89.9 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK68987.1 - 2e-05 24.7 0.0 8.9e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 VDK68987.1 - 0.00011 21.5 0.0 0.00024 20.4 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ABC_membrane PF00664.23 VDK68988.1 - 6.5e-09 35.8 25.1 1.3e-05 25.0 9.5 3.2 4 0 0 4 4 4 2 ABC transporter transmembrane region Kinesin PF00225.23 VDK68989.1 - 5.8e-80 268.7 0.0 1.2e-79 267.7 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain MKLP1_Arf_bdg PF16540.5 VDK68989.1 - 1.8e-35 121.2 0.0 4e-35 120.1 0.0 1.6 1 0 0 1 1 1 1 Arf6-interacting domain of mitotic kinesin-like protein 1 Microtub_bd PF16796.5 VDK68989.1 - 1.9e-14 53.8 0.1 7.2e-14 52.0 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding TAT_signal PF10518.9 VDK68989.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence DUF2344 PF10105.9 VDK68989.1 - 0.38 10.6 3.2 0.89 9.4 3.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) LMBR1 PF04791.16 VDK68989.1 - 8.7 5.1 7.6 14 4.5 7.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Lectin_C PF00059.21 VDK68990.1 - 1.3e-12 48.4 1.0 3.1e-12 47.2 1.0 1.7 1 0 0 1 1 1 1 Lectin C-type domain Lyase_N PF09092.11 VDK68990.1 - 0.046 13.6 0.2 0.1 12.5 0.1 1.5 2 0 0 2 2 2 0 Lyase, N terminal SET PF00856.28 VDK68991.1 - 1.4e-06 28.8 0.0 4.7e-06 27.1 0.0 1.9 2 1 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 VDK68991.1 - 0.00098 19.8 0.0 0.0031 18.2 0.0 1.8 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding EF-hand_6 PF13405.6 VDK68993.1 - 9.4e-09 34.5 0.6 0.0031 17.3 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 VDK68993.1 - 5.5e-08 31.8 2.5 0.022 14.3 0.1 4.0 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 VDK68993.1 - 1e-06 29.1 0.1 0.0037 17.7 0.1 2.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 VDK68993.1 - 0.0033 17.3 0.7 0.24 11.3 0.1 3.1 2 1 1 3 3 3 1 EF-hand domain pair Spa1_C PF18218.1 VDK68993.1 - 0.12 12.8 0.1 2.8 8.4 0.0 2.1 2 0 0 2 2 2 0 Lantibiotic immunity protein Spa1 C-terminal domain EF-hand_9 PF14658.6 VDK68993.1 - 0.13 12.6 0.0 22 5.5 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain PaRep2a PF07903.11 VDK68994.1 - 0.004 17.0 0.2 0.0058 16.5 0.2 1.3 1 1 0 1 1 1 1 PaRep2a protein Peptidase_C50 PF03568.17 VDK68995.1 - 1.2e-63 215.7 1.9 2.9e-53 181.4 0.0 2.9 2 1 1 3 3 3 2 Peptidase family C50 LRR_8 PF13855.6 VDK68996.1 - 6.9e-56 185.9 55.7 1.8e-15 56.4 0.5 7.5 3 1 4 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 VDK68996.1 - 1.7e-28 98.2 63.5 5e-06 26.8 1.7 8.0 4 1 3 8 8 8 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK68996.1 - 1.5e-16 60.6 7.6 2.9e-08 33.7 5.0 4.1 1 1 3 4 4 4 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 VDK68996.1 - 3.5e-16 59.2 32.8 6.8e-08 32.2 6.6 5.4 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 VDK68996.1 - 8.7e-09 34.7 46.7 1.7 9.5 0.2 12.4 9 2 0 9 9 9 5 Leucine Rich Repeat HTH_19 PF12844.7 VDK68996.1 - 0.032 14.2 0.8 5.9 7.0 0.1 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain HUN PF08729.10 VDK69001.1 - 1.4e-18 66.6 0.7 3.9e-18 65.2 0.7 1.8 1 0 0 1 1 1 1 HPC2 and ubinuclein domain UBN_AB PF14075.6 VDK69001.1 - 3.5e-05 23.6 18.1 0.0043 16.8 0.6 4.0 3 0 0 3 3 3 2 Ubinuclein conserved middle domain Trypsin PF00089.26 VDK69004.1 - 1.2e-29 103.7 0.0 1.7e-29 103.2 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 VDK69004.1 - 0.0012 19.7 0.0 0.0019 19.1 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 VDK69004.1 - 0.0012 18.4 0.0 0.27 10.8 0.0 2.2 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Proteasome PF00227.26 VDK69006.1 - 3.9e-55 186.3 0.0 5.1e-55 185.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 VDK69006.1 - 4.5e-14 51.8 0.1 7.7e-14 51.1 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF3072 PF11272.8 VDK69006.1 - 0.14 12.1 0.3 0.31 11.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) Use1 PF09753.9 VDK69008.1 - 1.4e-44 152.7 7.9 1.8e-44 152.3 7.9 1.0 1 0 0 1 1 1 1 Membrane fusion protein Use1 LRR_8 PF13855.6 VDK69009.1 - 9.6e-54 179.0 71.5 1.5e-11 43.9 8.4 7.0 2 2 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 VDK69009.1 - 2.3e-22 78.7 43.7 8.3e-05 22.9 2.7 7.9 6 2 1 8 8 8 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK69009.1 - 1.2e-20 73.8 3.1 7.2e-10 38.9 2.7 3.1 1 1 0 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 VDK69009.1 - 1.3e-10 40.3 43.3 0.14 12.8 0.1 12.9 13 1 1 14 14 14 5 Leucine Rich Repeat LRR_9 PF14580.6 VDK69009.1 - 1.2e-05 24.8 12.4 8.9e-05 22.1 3.5 3.6 1 1 3 4 4 4 2 Leucine-rich repeat LRRNT PF01462.18 VDK69009.1 - 9.5e-05 21.9 1.2 0.00032 20.3 1.2 1.9 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_6 PF13516.6 VDK69009.1 - 0.096 12.8 37.3 11 6.3 0.1 10.3 11 0 0 11 11 11 0 Leucine Rich repeat Tubulin PF00091.25 VDK69010.1 - 3.8e-68 229.6 0.0 5.1e-68 229.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK69010.1 - 8.3e-49 164.9 0.0 1.3e-48 164.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK69010.1 - 0.00028 20.6 0.0 0.00052 19.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Glycos_transf_2 PF00535.26 VDK69011.1 - 4.7e-34 117.6 0.0 8.7e-34 116.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 VDK69011.1 - 7.9e-26 90.8 0.6 1.5e-25 89.9 0.6 1.5 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 VDK69011.1 - 1.9e-08 34.5 0.0 2.9e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 VDK69011.1 - 9.1e-08 31.7 0.0 2.4e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 VDK69011.1 - 0.0015 19.2 0.1 1.2 9.9 0.1 2.7 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 VDK69011.1 - 0.0087 15.6 0.0 0.049 13.1 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 tRNA_int_endo_N PF02778.14 VDK69069.1 - 0.003 17.2 0.0 0.0047 16.6 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain STAG PF08514.11 VDK69070.1 - 2.4e-29 101.5 0.0 2.5e-28 98.3 0.0 2.8 2 0 0 2 2 2 1 STAG domain Cnd1 PF12717.7 VDK69070.1 - 0.0097 16.0 0.1 0.0097 16.0 0.1 3.0 4 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 TfuA PF07812.12 VDK69070.1 - 0.12 12.2 1.1 2.7 7.7 0.2 2.9 2 0 0 2 2 2 0 TfuA-like protein UNC45-central PF11701.8 VDK69070.1 - 0.16 11.9 3.6 0.75 9.7 0.0 3.3 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central Innexin PF00876.18 VDK69072.1 - 7.7e-109 364.2 12.4 9.5e-109 363.9 12.4 1.0 1 0 0 1 1 1 1 Innexin EGF PF00008.27 VDK69073.1 - 2.4e-50 168.4 146.5 7.2e-10 39.0 7.6 11.0 10 1 0 10 10 10 9 EGF-like domain hEGF PF12661.7 VDK69073.1 - 4.1e-31 106.5 121.5 3.9e-05 24.1 6.7 12.2 10 1 0 10 10 10 9 Human growth factor-like EGF DSL PF01414.19 VDK69073.1 - 1.4e-17 63.7 2.1 1.4e-17 63.7 2.1 8.8 6 3 2 8 8 8 2 Delta serrate ligand EGF_2 PF07974.13 VDK69073.1 - 1.6e-09 38.0 179.2 0.066 13.6 11.3 11.6 11 0 0 11 11 11 9 EGF-like domain EGF_CA PF07645.15 VDK69073.1 - 0.001 19.2 143.1 0.017 15.3 14.7 11.0 2 2 7 10 10 10 5 Calcium-binding EGF domain EGF_3 PF12947.7 VDK69073.1 - 0.0091 16.2 15.4 0.0091 16.2 15.4 10.3 8 1 1 9 9 9 5 EGF domain CAP PF00188.26 VDK69074.1 - 1.7e-13 51.5 0.2 3.5e-13 50.5 0.2 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family TDH PF03347.13 VDK69074.1 - 0.018 14.6 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 Vibrio thermostable direct hemolysin Peptidase_M41 PF01434.18 VDK69075.1 - 3.3e-60 203.2 0.1 6.4e-60 202.3 0.1 1.5 1 1 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 VDK69075.1 - 8.5e-41 139.5 0.1 4.3e-39 134.0 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK69075.1 - 7.5e-12 44.9 0.0 1.7e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 VDK69075.1 - 0.00015 22.2 0.7 0.0027 18.1 0.5 2.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 VDK69075.1 - 0.00017 21.8 0.2 0.018 15.3 0.0 2.8 2 1 0 3 3 2 1 AAA domain AAA_2 PF07724.14 VDK69075.1 - 0.00017 21.7 0.0 0.00045 20.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 VDK69075.1 - 0.00024 21.5 0.0 0.00059 20.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 VDK69075.1 - 0.00033 20.7 0.1 0.0017 18.4 0.0 2.3 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 VDK69075.1 - 0.0016 18.2 0.2 0.0072 16.1 0.1 2.3 3 1 0 3 3 3 1 IstB-like ATP binding protein AAA_28 PF13521.6 VDK69075.1 - 0.0023 18.2 0.1 0.0067 16.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 VDK69075.1 - 0.0029 16.9 0.0 0.0058 15.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 VDK69075.1 - 0.0033 18.0 0.0 0.02 15.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 VDK69075.1 - 0.0036 17.1 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 VDK69075.1 - 0.0044 16.6 0.1 0.017 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 VDK69075.1 - 0.0093 16.0 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 VDK69075.1 - 0.018 14.9 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 VDK69075.1 - 0.034 14.3 0.0 0.097 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 VDK69075.1 - 0.039 13.2 0.0 0.089 12.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.21 VDK69075.1 - 0.04 13.3 0.1 0.075 12.4 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 VDK69075.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase HhH-GPD PF00730.25 VDK69075.1 - 0.12 12.9 0.0 14 6.2 0.0 3.1 2 1 0 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein Sigma54_activ_2 PF14532.6 VDK69075.1 - 0.12 12.4 0.1 0.53 10.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain BolA PF01722.18 VDK69077.1 - 1.4e-24 86.1 0.1 2.8e-24 85.2 0.1 1.5 1 0 0 1 1 1 1 BolA-like protein Bax1-I PF01027.20 VDK69078.1 - 1.9e-45 155.3 20.0 3.8e-45 154.3 20.0 1.5 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Na_Ca_ex PF01699.24 VDK69079.1 - 5.2e-50 169.3 51.4 5.8e-27 94.5 21.4 2.8 3 0 0 3 3 3 2 Sodium/calcium exchanger protein Cadherin_C_2 PF16492.5 VDK69079.1 - 0.0036 18.0 2.6 0.0036 18.0 2.6 3.6 4 0 0 4 4 4 1 Cadherin cytoplasmic C-terminal C2 PF00168.30 VDK69080.1 - 1.8e-39 134.2 0.0 1.1e-11 44.9 0.0 6.6 5 1 0 5 5 5 5 C2 domain Ferlin_C PF16165.5 VDK69080.1 - 3.1e-21 75.9 0.0 3.1e-21 75.9 0.0 2.5 3 0 0 3 3 3 1 Ferlin C-terminus FerB PF08150.12 VDK69080.1 - 9.9e-20 70.9 0.0 2.8e-19 69.5 0.0 1.9 1 0 0 1 1 1 1 FerB (NUC096) domain Pex24p PF06398.11 VDK69080.1 - 0.00018 20.6 15.3 0.03 13.3 14.4 3.1 2 1 0 2 2 2 1 Integral peroxisomal membrane peroxin Collagen PF01391.18 VDK69082.1 - 8.7e-26 89.5 92.3 4.8e-10 39.0 33.8 3.9 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK69082.1 - 2.7e-11 43.3 0.3 4.2e-11 42.7 0.3 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain CDP-OH_P_transf PF01066.21 VDK69086.1 - 7.8e-13 49.0 0.3 7.8e-13 49.0 0.3 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF4400 PF14348.6 VDK69086.1 - 1 8.8 5.0 0.18 11.3 1.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4400) TRAM_LAG1_CLN8 PF03798.16 VDK69090.1 - 4.2e-14 52.8 17.3 6e-14 52.2 17.3 1.2 1 0 0 1 1 1 1 TLC domain Sprouty PF05210.13 VDK69093.1 - 8.4e-19 67.9 3.6 1.4e-18 67.2 3.6 1.3 1 0 0 1 1 1 1 Sprouty protein (Spry) zf-C2HE PF16278.5 VDK69093.1 - 0.045 14.2 0.1 0.084 13.3 0.1 1.5 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Met_10 PF02475.16 VDK69098.1 - 1.1e-31 110.1 0.0 2.6e-31 108.9 0.0 1.6 2 0 0 2 2 2 1 Met-10+ like-protein DNA_methylase PF00145.17 VDK69098.1 - 6e-05 22.5 2.1 0.014 14.8 0.0 2.2 2 0 0 2 2 2 2 C-5 cytosine-specific DNA methylase Methyltransf_15 PF09445.10 VDK69098.1 - 6e-05 22.7 0.2 0.00014 21.4 0.0 1.7 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase MTS PF05175.14 VDK69098.1 - 7.8e-05 22.3 0.0 0.00019 21.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 VDK69098.1 - 0.00015 22.4 0.0 0.00034 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.16 VDK69098.1 - 0.00024 20.4 0.7 0.0006 19.1 0.0 1.8 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase Cons_hypoth95 PF03602.15 VDK69098.1 - 0.00037 20.2 0.1 0.0018 18.0 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 VDK69098.1 - 0.00038 20.3 0.0 0.00093 19.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 VDK69098.1 - 0.00058 19.8 0.1 0.0026 17.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 VDK69098.1 - 0.01 15.2 1.2 0.012 15.0 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) PRMT5 PF05185.16 VDK69098.1 - 0.017 14.9 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase UPF0020 PF01170.18 VDK69098.1 - 0.098 12.3 0.2 0.25 11.0 0.0 1.7 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 VDK69098.1 - 0.1 13.3 0.0 0.22 12.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 VDK69098.1 - 0.1 13.6 0.0 0.27 12.3 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain TB2_DP1_HVA22 PF03134.19 VDK69099.1 - 4e-17 61.9 1.0 6.3e-17 61.3 1.0 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Proteasome PF00227.26 VDK69100.1 - 2.6e-43 147.7 1.3 3e-43 147.5 1.3 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF4914 PF16260.5 VDK69100.1 - 0.043 11.9 0.0 0.059 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) Peptidase_M1 PF01433.20 VDK69103.1 - 2.1e-67 226.9 0.8 1e-66 224.6 0.8 2.3 1 1 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 VDK69103.1 - 5.7e-58 196.9 0.6 5.7e-58 196.9 0.6 1.6 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 VDK69103.1 - 1.5e-44 152.5 0.6 2.1e-37 129.1 0.0 2.6 1 1 1 2 2 2 2 Peptidase M1 N-terminal domain TRAP_beta PF05753.14 VDK69103.1 - 0.047 13.1 0.2 0.089 12.2 0.2 1.4 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) Metallophos_C PF14008.6 VDK69104.1 - 8.5e-23 81.0 0.4 3e-22 79.2 0.0 2.2 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 VDK69104.1 - 2.5e-17 63.2 0.1 5.9e-17 62.0 0.1 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 VDK69104.1 - 8.8e-15 55.7 0.4 8.8e-15 55.7 0.4 2.3 3 1 0 3 3 3 1 Calcineurin-like phosphoesterase PTH2 PF01981.16 VDK69108.1 - 1.8e-34 118.5 0.0 2e-34 118.3 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Herpes_BTRF1 PF04682.12 VDK69149.1 - 0.12 11.7 0.2 0.28 10.5 0.1 1.6 1 1 1 2 2 2 0 Herpesvirus BTRF1 protein conserved region UDPGT PF00201.18 VDK69150.1 - 1.9e-73 248.0 0.6 2.4e-73 247.6 0.6 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 VDK69150.1 - 1.6e-08 34.8 0.0 3.8e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain LRR_6 PF13516.6 VDK69151.1 - 0.00025 20.9 5.9 0.93 9.7 0.3 6.0 5 0 0 5 5 5 3 Leucine Rich repeat PHD PF00628.29 VDK69153.1 - 7.9e-12 44.9 17.7 1.6e-06 27.9 6.3 2.6 1 1 1 2 2 2 2 PHD-finger PHD_4 PF16866.5 VDK69153.1 - 2.6e-06 27.4 13.8 7e-05 22.8 3.8 2.9 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H PF13771.6 VDK69153.1 - 0.00074 19.7 20.4 0.61 10.4 6.3 3.6 2 1 1 3 3 3 2 PHD-like zinc-binding domain C1_1 PF00130.22 VDK69153.1 - 0.0014 18.5 19.4 0.029 14.2 2.1 3.6 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H_2 PF13832.6 VDK69153.1 - 0.16 12.1 18.9 11 6.3 4.9 3.3 1 1 2 3 3 3 0 PHD-zinc-finger like domain RE_NgoPII PF09521.10 VDK69153.1 - 1 8.5 7.4 1.8 7.7 0.4 2.5 2 1 0 2 2 2 0 NgoPII restriction endonuclease Prok-RING_1 PF14446.6 VDK69153.1 - 3.1 7.8 18.7 2.1 8.3 2.8 3.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 MOZ_SAS PF01853.18 VDK69154.1 - 8.7e-28 97.2 0.1 1.3e-27 96.6 0.1 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 VDK69154.1 - 3.9e-12 45.6 0.5 8.2e-12 44.5 0.5 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain F-box-like PF12937.7 VDK69155.1 - 1.4e-08 34.5 1.2 5.2e-08 32.7 1.2 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 VDK69155.1 - 0.00014 21.6 0.8 0.00039 20.2 0.8 1.8 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 VDK69155.1 - 0.00016 22.4 12.4 1.5 9.8 0.1 5.5 5 1 1 6 6 6 3 WD domain, G-beta repeat PI-PLC-X PF00388.19 VDK69158.1 - 2.8e-57 192.4 0.0 7.8e-57 190.9 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 VDK69158.1 - 1.2e-40 138.4 0.7 2.8e-40 137.3 0.7 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain SH2 PF00017.24 VDK69158.1 - 3.1e-37 126.5 5.1 9e-19 67.4 0.6 3.5 3 0 0 3 3 3 2 SH2 domain C2 PF00168.30 VDK69158.1 - 1.2e-14 54.4 0.0 4e-14 52.7 0.0 1.9 1 0 0 1 1 1 1 C2 domain PH PF00169.29 VDK69158.1 - 4.1e-10 40.1 0.8 1.2e-05 25.7 0.0 3.9 4 0 0 4 4 4 2 PH domain SH3_9 PF14604.6 VDK69158.1 - 0.00022 21.0 0.0 0.00064 19.5 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK69158.1 - 0.014 15.0 0.0 0.037 13.6 0.0 1.8 1 0 0 1 1 1 0 SH3 domain SH3_2 PF07653.17 VDK69158.1 - 0.038 13.7 0.0 0.096 12.4 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain 7TM_GPCR_Srsx PF10320.9 VDK69160.1 - 8.1e-10 38.5 21.0 1.3e-09 37.9 21.0 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srbc PF10316.9 VDK69160.1 - 0.0024 17.4 22.3 0.007 15.9 22.3 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc Forkhead PF00250.18 VDK69162.1 - 6e-37 125.8 0.0 1.1e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain DUF5544 PF17698.1 VDK69162.1 - 4.3 7.4 10.4 0.15 12.1 3.2 2.1 2 1 1 3 3 3 0 Family of unknown function (DUF5544) DUF1794 PF08768.11 VDK69163.1 - 1.6e-05 24.9 0.0 3.4e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1794) Tim17 PF02466.19 VDK69164.1 - 3.4e-25 88.6 4.7 4.2e-25 88.3 4.7 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF456 PF04306.13 VDK69164.1 - 0.081 13.2 3.0 6.5 7.0 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF456) Gly-zipper_YMGG PF13441.6 VDK69164.1 - 8.5 6.2 11.4 1.9 8.3 4.7 2.2 2 0 0 2 2 2 0 YMGG-like Gly-zipper LMBR1 PF04791.16 VDK69165.1 - 6.7e-137 457.5 26.9 7.7e-137 457.3 26.9 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein DSPc PF00782.20 VDK69166.1 - 4.2e-25 88.1 0.0 5.4e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 VDK69166.1 - 0.00048 20.3 0.0 0.00065 19.8 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 VDK69166.1 - 0.00064 19.4 0.1 0.00083 19.0 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF442 PF04273.13 VDK69166.1 - 0.078 13.1 0.1 0.15 12.2 0.1 1.6 1 1 0 1 1 1 0 Putative phosphatase (DUF442) Y_phosphatase2 PF03162.13 VDK69166.1 - 0.1 12.1 0.1 0.35 10.4 0.0 1.9 2 1 1 3 3 3 0 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 VDK69166.1 - 0.11 12.8 0.0 0.26 11.6 0.0 1.5 2 0 0 2 2 2 0 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 VDK69166.1 - 0.12 12.3 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Sec2p PF06428.11 VDK69167.1 - 7.7e-07 29.0 2.2 1.4e-06 28.2 2.2 1.4 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p Tropomyosin PF00261.20 VDK69167.1 - 0.057 12.8 8.9 0.28 10.5 8.9 1.9 1 1 0 1 1 1 0 Tropomyosin Matrilin_ccoil PF10393.9 VDK69167.1 - 0.072 13.0 3.5 0.39 10.6 0.2 2.5 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin EcoEI_R_C PF08463.10 VDK69167.1 - 0.23 11.6 1.2 1.3 9.2 1.2 2.1 1 1 0 1 1 1 0 EcoEI R protein C-terminal CorA PF01544.18 VDK69167.1 - 0.31 10.3 2.0 0.5 9.6 2.0 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Spc7 PF08317.11 VDK69167.1 - 0.31 9.9 3.7 0.51 9.2 3.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein GDP_Man_Dehyd PF16363.5 VDK69168.1 - 1.3e-48 166.1 0.2 6.2e-44 150.8 0.0 2.9 2 1 1 3 3 3 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 VDK69168.1 - 1.3e-46 159.0 1.4 3.1e-40 138.2 1.1 3.5 2 2 0 2 2 2 2 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 VDK69168.1 - 3.5e-15 55.9 0.1 3.2e-10 39.6 0.0 4.2 3 1 1 4 4 4 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 VDK69168.1 - 4.3e-14 52.3 0.0 4.2e-10 39.2 0.0 2.6 2 1 0 2 2 2 2 RmlD substrate binding domain NAD_binding_4 PF07993.12 VDK69168.1 - 5.7e-13 48.6 0.0 7.8e-10 38.3 0.0 3.1 2 1 1 3 3 3 1 Male sterility protein 3Beta_HSD PF01073.19 VDK69168.1 - 1.8e-12 46.9 0.9 1e-06 28.0 0.1 3.2 2 1 1 3 3 3 3 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 VDK69168.1 - 0.033 13.7 0.0 1.4 8.3 0.0 2.9 3 0 0 3 3 3 0 short chain dehydrogenase BACK PF07707.15 VDK69170.1 - 3.2e-07 30.4 0.2 6.4e-07 29.4 0.2 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 VDK69170.1 - 0.00024 21.3 0.0 0.00051 20.3 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain DUF4062 PF13271.6 VDK69171.1 - 0.043 14.2 0.9 0.12 12.8 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4062) zf-C2H2_4 PF13894.6 VDK69171.1 - 0.21 12.5 15.7 2.8 9.0 0.4 5.0 5 0 0 5 5 5 0 C2H2-type zinc finger zf-Mss51 PF13824.6 VDK69171.1 - 0.43 10.7 7.4 0.42 10.7 0.9 3.2 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2H2_12 PF18658.1 VDK69171.1 - 1.1 8.9 16.0 0.19 11.3 0.4 3.9 3 1 0 4 4 4 0 Zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 VDK69171.1 - 1.5 9.0 5.9 38 4.5 0.1 3.5 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2 PF00096.26 VDK69171.1 - 4.3 8.0 18.9 1.9 9.1 0.6 4.7 5 0 0 5 5 5 0 Zinc finger, C2H2 type Rubredoxin_2 PF18073.1 VDK69171.1 - 5.1 6.9 5.8 33 4.3 0.2 2.7 2 0 0 2 2 2 0 Rubredoxin metal binding domain C1_4 PF07975.12 VDK69171.1 - 5.8 7.2 7.3 3 8.1 0.8 2.8 2 0 0 2 2 2 0 TFIIH C1-like domain Stc1 PF12898.7 VDK69171.1 - 6 7.5 14.9 0.94 10.1 2.7 3.2 3 0 0 3 3 3 0 Stc1 domain zinc-ribbons_6 PF07191.12 VDK69171.1 - 6.9 6.7 9.0 20 5.2 1.7 3.0 2 0 0 2 2 2 0 zinc-ribbons UCH PF00443.29 VDK69172.1 - 5.7e-40 137.4 1.5 5.7e-40 137.4 1.5 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase OTU PF02338.19 VDK69172.1 - 8.1e-11 42.5 0.1 5e-10 40.0 0.0 2.3 2 0 0 2 2 2 1 OTU-like cysteine protease TetR_C_37 PF18665.1 VDK69172.1 - 0.0025 18.4 0.8 0.0082 16.7 0.8 1.9 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain UCH_1 PF13423.6 VDK69172.1 - 0.024 14.2 20.6 0.3 10.6 10.9 2.9 3 1 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase Dodecin PF07311.12 VDK69172.1 - 0.22 11.8 0.6 0.63 10.3 0.6 1.7 1 0 0 1 1 1 0 Dodecin ArsA_ATPase PF02374.15 VDK69173.1 - 9.3e-114 379.7 0.1 1.1e-113 379.5 0.1 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 VDK69173.1 - 7.2e-12 45.6 0.0 2.5e-11 43.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 VDK69173.1 - 4.9e-10 39.5 0.1 5e-09 36.3 0.1 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 VDK69173.1 - 7.8e-05 22.2 3.7 0.0016 17.9 1.9 2.7 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 VDK69173.1 - 0.00025 20.6 0.0 0.00068 19.2 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Elf1 PF05129.13 VDK69173.1 - 0.00061 19.8 0.5 0.0015 18.5 0.5 1.6 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like CBP_BcsQ PF06564.12 VDK69173.1 - 0.00079 19.0 0.0 0.0014 18.2 0.0 1.5 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 VDK69173.1 - 0.0011 18.6 0.0 0.036 13.7 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 VDK69173.1 - 0.019 14.5 0.5 0.13 11.8 0.5 2.2 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 VDK69173.1 - 0.037 13.2 0.0 0.076 12.2 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 VDK69173.1 - 0.068 12.4 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin MeaB PF03308.16 VDK69173.1 - 0.14 11.1 0.1 12 4.8 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Collagen PF01391.18 VDK69174.1 - 1.7e-06 27.7 31.8 0.00028 20.6 31.8 2.3 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Ceramidase PF05875.12 VDK69175.1 - 2.7e-21 76.2 9.9 4.3e-12 46.0 5.3 2.0 1 1 1 2 2 2 2 Ceramidase Anp1 PF03452.14 VDK69176.1 - 0.00062 19.3 0.1 1 8.7 0.0 3.1 3 0 0 3 3 3 3 Anp1 2OG-FeII_Oxy_3 PF13640.6 VDK69176.1 - 0.00066 20.5 0.1 0.0015 19.4 0.1 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_tranf_2_3 PF13641.6 VDK69177.1 - 7.3e-06 26.0 0.0 0.00031 20.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Anp1 PF03452.14 VDK69177.1 - 0.087 12.2 0.1 0.37 10.2 0.1 1.9 1 1 1 2 2 2 0 Anp1 PurS PF02700.14 VDK69222.1 - 0.057 13.6 0.5 14 5.9 0.5 2.6 2 0 0 2 2 2 0 Phosphoribosylformylglycinamidine (FGAM) synthase CDC37_N PF03234.14 VDK69222.1 - 1 10.3 6.4 0.38 11.7 3.8 1.6 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding PGBA_C PF15437.6 VDK69222.1 - 1 9.8 8.7 1 9.8 1.1 2.9 3 0 0 3 3 3 0 Plasminogen-binding protein pgbA C-terminal Homeodomain PF00046.29 VDK69225.1 - 5.3e-20 71.0 1.2 8.5e-20 70.4 1.2 1.3 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 VDK69225.1 - 1.9e-15 56.8 4.3 1.9e-15 56.8 4.3 1.9 2 0 0 2 2 2 1 LIM domain Homeobox_KN PF05920.11 VDK69225.1 - 0.00059 19.7 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain PHF5 PF03660.14 VDK69225.1 - 0.068 13.4 4.8 0.12 12.6 4.8 1.4 1 0 0 1 1 1 0 PHF5-like protein DUF2175 PF09943.9 VDK69225.1 - 1.6 9.1 4.2 4.2 7.7 0.7 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) YqgB PF11036.8 VDK69227.1 - 0.11 12.2 0.3 0.2 11.4 0.3 1.5 1 0 0 1 1 1 0 Virulence promoting factor STAR_dimer PF16544.5 VDK69229.1 - 4.6e-24 83.7 0.2 8.8e-24 82.8 0.2 1.5 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein KH_1 PF00013.29 VDK69229.1 - 6.1e-07 29.2 0.1 1.3e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 KH domain 7TM_GPCR_Srv PF10323.9 VDK69231.1 - 0.094 12.1 0.1 0.12 11.7 0.1 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv EB PF01683.18 VDK69232.1 - 5.6e-77 253.9 220.4 3.1e-08 33.8 3.8 16.8 9 4 8 17 17 17 15 EB module Polysacc_deac_1 PF01522.21 VDK69232.1 - 4.8e-06 26.5 0.0 2.9e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide deacetylase SCHIP-1 PF10148.9 VDK69233.1 - 8.8e-25 87.7 12.1 8.8e-25 87.7 12.1 3.3 1 1 2 3 3 3 1 Schwannomin-interacting protein 1 EURL PF06937.11 VDK69233.1 - 0.00078 18.9 3.4 0.0017 17.8 3.4 1.6 1 0 0 1 1 1 1 EURL protein EcoR124_C PF12008.8 VDK69233.1 - 0.054 13.1 3.0 0.048 13.3 1.2 1.8 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal Cpn60_TCP1 PF00118.24 VDK69235.1 - 1e-22 80.4 0.7 1.6e-22 79.9 0.7 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 VDK69235.1 - 9.1e-17 61.0 9.1 9.1e-17 61.0 9.1 2.6 3 0 0 3 3 3 1 FYVE zinc finger DUF4969 PF16339.5 VDK69235.1 - 6.6 7.2 6.6 5.9 7.3 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4969) PIP5K PF01504.18 VDK69236.1 - 3.1e-44 151.2 3.3 1.1e-36 126.5 1.6 2.3 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Surp PF01805.20 VDK69237.1 - 1.5e-17 63.3 0.1 3.9e-17 62.0 0.1 1.8 1 0 0 1 1 1 1 Surp module RRM_1 PF00076.22 VDK69237.1 - 1.3e-09 37.7 0.0 2.9e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cwf21 PF08312.12 VDK69237.1 - 2.7e-09 37.0 7.8 2.7e-09 37.0 7.8 3.9 4 0 0 4 4 4 1 cwf21 domain CTD_bind PF04818.13 VDK69237.1 - 0.00028 21.6 0.9 0.0014 19.4 0.1 2.6 2 0 0 2 2 2 1 RNA polymerase II-binding domain. Mo25 PF08569.11 VDK69239.1 - 4.6e-140 466.6 14.8 5.2e-140 466.5 14.8 1.0 1 0 0 1 1 1 1 Mo25-like Occludin_ELL PF07303.13 VDK69239.1 - 4.7 8.0 7.7 6.8 7.5 0.1 3.2 5 0 0 5 5 5 0 Occludin homology domain Rdx PF10262.9 VDK69240.1 - 4.8e-16 58.7 0.0 7.9e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Rdx family Elicitin PF00964.17 VDK69243.1 - 1.3 9.2 4.1 13 6.0 0.4 3.2 3 0 0 3 3 3 0 Elicitin CUB PF00431.20 VDK69246.1 - 1.8e-41 140.9 1.1 1.8e-15 57.2 0.0 4.4 4 0 0 4 4 4 4 CUB domain IFNGR1 PF07140.11 VDK69246.1 - 0.17 12.0 2.4 11 6.1 0.0 3.5 3 0 0 3 3 3 0 Interferon gamma receptor (IFNGR1) DUF4405 PF14358.6 VDK69246.1 - 0.36 11.4 1.9 1 9.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) Cullin_binding PF03556.15 VDK69247.1 - 8e-34 116.7 0.2 1.4e-33 115.9 0.2 1.4 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 VDK69247.1 - 3.6e-08 33.1 1.7 5.7e-08 32.4 0.2 2.1 3 0 0 3 3 3 1 UBA-like domain TAP_C PF03943.13 VDK69247.1 - 0.041 13.5 1.4 0.67 9.6 2.7 2.3 2 0 0 2 2 2 0 TAP C-terminal domain CUE PF02845.16 VDK69247.1 - 0.098 12.4 0.1 0.45 10.3 0.0 2.0 2 0 0 2 2 2 0 CUE domain zf-Nse PF11789.8 VDK69248.1 - 3e-11 42.9 1.7 5.3e-11 42.2 1.7 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Glu-tRNAGln PF02686.15 VDK69248.1 - 0.027 14.8 0.5 4.9 7.5 0.0 3.0 2 1 1 3 3 3 0 Glu-tRNAGln amidotransferase C subunit LANC_like PF05147.13 VDK69248.1 - 0.062 11.9 0.0 0.081 11.5 0.0 1.1 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein DUF5069 PF16798.5 VDK69248.1 - 0.074 13.3 1.5 0.093 12.9 0.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5069) Mito_carr PF00153.27 VDK69249.1 - 2.3e-19 69.1 0.0 1.9e-09 37.3 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein RhoGEF PF00621.20 VDK69251.1 - 6.4e-43 147.1 0.2 9.3e-43 146.6 0.2 1.2 1 0 0 1 1 1 1 RhoGEF domain SH3_2 PF07653.17 VDK69251.1 - 1.8e-09 37.1 0.0 4.1e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 VDK69251.1 - 4e-06 26.6 0.1 8e-06 25.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK69251.1 - 6e-06 25.8 0.0 1.1e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain PH_5 PF15405.6 VDK69251.1 - 0.098 12.8 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain SSP160 PF06933.11 VDK69251.1 - 0.34 9.1 4.3 0.45 8.7 4.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ABC_tran PF00005.27 VDK69253.1 - 1.2e-38 132.7 0.6 1.4e-27 96.9 0.0 3.3 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 VDK69253.1 - 2.6e-16 60.3 1.9 2e-06 27.8 0.0 3.2 2 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 VDK69253.1 - 1.1e-09 38.0 1.7 0.00048 19.6 0.0 3.5 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 VDK69253.1 - 1.2e-08 34.8 8.7 2.9e-08 33.6 8.7 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 VDK69253.1 - 1.6e-05 25.5 6.6 0.023 15.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 VDK69253.1 - 3.4e-05 23.8 0.7 0.00025 21.0 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 VDK69253.1 - 0.00022 21.1 6.7 0.023 14.4 0.0 2.8 2 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 VDK69253.1 - 0.00059 20.1 0.2 0.0067 16.7 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 VDK69253.1 - 0.0009 19.8 2.0 0.0075 16.8 0.0 3.0 2 2 0 2 2 2 1 AAA domain AAA_16 PF13191.6 VDK69253.1 - 0.001 19.4 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 VDK69253.1 - 0.0011 18.7 0.8 0.01 15.6 0.1 2.6 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 VDK69253.1 - 0.0023 17.6 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase_2 PF01637.18 VDK69253.1 - 0.004 17.1 2.2 3.3 7.6 2.3 2.2 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 VDK69253.1 - 0.0053 16.8 2.1 0.0063 16.6 0.2 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase SbcCD_C PF13558.6 VDK69253.1 - 0.0067 16.6 0.3 0.91 9.8 0.2 3.5 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_28 PF13521.6 VDK69253.1 - 0.014 15.7 0.1 0.033 14.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain PEARLI-4 PF05278.12 VDK69253.1 - 0.014 15.0 2.4 0.021 14.4 2.4 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) AAA PF00004.29 VDK69253.1 - 0.018 15.5 0.1 0.24 11.8 0.0 2.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 VDK69253.1 - 0.028 14.3 0.8 0.23 11.4 0.0 2.5 2 0 0 2 2 2 0 NTPase RNA_helicase PF00910.22 VDK69253.1 - 0.038 14.4 0.0 0.12 12.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase DUF87 PF01935.17 VDK69253.1 - 0.038 14.1 0.6 1.8 8.6 0.0 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain NACHT PF05729.12 VDK69253.1 - 0.041 13.8 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 VDK69253.1 - 0.049 13.7 0.0 0.23 11.5 0.0 2.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 VDK69253.1 - 0.088 12.9 0.1 4.4 7.3 0.0 2.3 2 0 0 2 2 2 0 Dynamin family Com_YlbF PF06133.11 VDK69253.1 - 0.092 13.4 7.9 0.23 12.1 7.9 1.6 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA IstB_IS21 PF01695.17 VDK69253.1 - 0.1 12.3 0.0 2.6 7.7 0.0 2.7 2 1 1 3 3 3 0 IstB-like ATP binding protein Cytidylate_kin PF02224.18 VDK69253.1 - 0.11 12.3 0.4 0.56 9.9 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase AAA_33 PF13671.6 VDK69253.1 - 0.11 12.7 0.0 0.61 10.2 0.0 2.2 3 0 0 3 3 3 0 AAA domain EMC3_TMCO1 PF01956.16 VDK69253.1 - 0.12 12.1 4.8 0.18 11.5 4.8 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF3584 PF12128.8 VDK69253.1 - 0.16 9.5 5.5 1.3 6.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Utp21 PF04192.12 VDK69257.1 - 6.2e-44 150.2 0.2 9.9e-44 149.6 0.2 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 VDK69257.1 - 9e-22 77.2 0.0 5.6e-05 23.4 0.0 7.3 4 2 4 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK69257.1 - 8e-19 67.7 7.2 2.3e-05 25.0 0.1 7.6 7 0 0 7 7 6 4 WD domain, G-beta repeat ABC_tran PF00005.27 VDK69257.1 - 8.4e-07 29.6 0.0 2.8e-06 27.9 0.0 1.9 1 0 0 1 1 1 1 ABC transporter WD40_like PF17005.5 VDK69257.1 - 0.0033 16.8 0.4 1.2 8.4 0.0 2.8 2 0 0 2 2 2 2 WD40-like domain NACHT PF05729.12 VDK69257.1 - 0.03 14.2 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain cobW PF02492.19 VDK69257.1 - 0.036 13.7 0.0 0.42 10.2 0.0 2.4 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 VDK69257.1 - 0.045 13.8 0.0 0.091 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytochrom_D1 PF02239.16 VDK69257.1 - 0.05 12.1 0.0 2.4 6.6 0.0 2.6 2 0 0 2 2 2 0 Cytochrome D1 heme domain PQQ_2 PF13360.6 VDK69257.1 - 0.059 12.9 0.0 0.39 10.2 0.0 1.9 1 1 1 2 2 2 0 PQQ-like domain AAA_21 PF13304.6 VDK69257.1 - 0.083 12.7 0.0 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 VDK69257.1 - 0.092 13.2 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ge1_WD40 PF16529.5 VDK69257.1 - 0.094 11.7 0.1 4.1 6.3 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ATPase_2 PF01637.18 VDK69257.1 - 0.1 12.5 0.2 0.3 11.0 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 VDK69257.1 - 0.74 10.3 5.6 0.28 11.7 0.2 2.4 1 1 1 2 2 2 0 AAA domain Innexin PF00876.18 VDK69259.1 - 2.2e-107 359.4 8.9 9.9e-106 354.0 8.9 2.0 1 1 0 1 1 1 1 Innexin CCSMST1 PF15013.6 VDK69259.1 - 2.9 8.1 10.8 2.7 8.2 0.1 3.3 3 0 0 3 3 3 0 CCSMST1 family PSI PF01437.25 VDK69262.1 - 0.0074 16.8 3.6 0.026 15.0 3.6 1.9 1 1 0 1 1 1 1 Plexin repeat PRIMA1 PF16101.5 VDK69262.1 - 0.12 12.4 12.2 0.22 11.6 12.2 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Androgen_recep PF02166.16 VDK69262.1 - 0.29 10.0 2.9 0.45 9.3 2.9 1.3 1 0 0 1 1 1 0 Androgen receptor CAP_N PF01213.19 VDK69262.1 - 1 8.8 7.5 1.6 8.2 7.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 VDK69262.1 - 2.7 8.0 5.8 4.1 7.4 5.8 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator NDUFV3 PF15880.5 VDK69264.1 - 6.2e-12 45.3 2.8 8.7e-12 44.8 2.8 1.2 1 0 0 1 1 1 1 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial XylR_N PF06505.11 VDK69264.1 - 0.19 11.5 0.0 0.25 11.1 0.0 1.2 1 0 0 1 1 1 0 Activator of aromatic catabolism OTU PF02338.19 VDK69266.1 - 3.5e-17 63.1 0.3 1e-16 61.6 0.0 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Yippee-Mis18 PF03226.14 VDK69266.1 - 6.5e-11 42.4 0.2 1.9e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Peptidase_C65 PF10275.9 VDK69266.1 - 3.8e-07 29.8 0.5 0.0013 18.3 0.1 2.6 2 0 0 2 2 2 2 Peptidase C65 Otubain RIG-I_C-RD PF11648.8 VDK69266.1 - 0.0092 16.2 0.8 0.03 14.5 0.1 2.1 2 0 0 2 2 2 1 C-terminal domain of RIG-I UIM PF02809.20 VDK69266.1 - 0.035 14.0 1.1 0.18 11.8 1.1 2.3 1 0 0 1 1 1 0 Ubiquitin interaction motif CSTF_C PF14304.6 VDK69266.1 - 3.8 7.2 6.3 0.18 11.5 0.7 1.7 2 0 0 2 2 2 0 Transcription termination and cleavage factor C-terminal BTB_2 PF02214.22 VDK69318.1 - 2.2e-26 92.0 0.2 3.3e-26 91.5 0.2 1.2 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 VDK69318.1 - 0.00042 20.4 0.0 0.00065 19.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans PF00520.31 VDK69320.1 - 7.7e-45 153.0 19.0 9.1e-45 152.8 19.0 1.0 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 VDK69320.1 - 2.7e-12 46.5 6.3 2.7e-12 46.5 6.3 2.7 2 1 1 3 3 3 1 Ion channel Lig_chan PF00060.26 VDK69320.1 - 0.0028 17.5 0.4 0.0028 17.5 0.4 2.2 2 0 0 2 2 2 1 Ligand-gated ion channel DUF4212 PF13937.6 VDK69320.1 - 4.3 7.8 13.0 0.22 11.9 2.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4212) zf-C2H2_4 PF13894.6 VDK69321.1 - 2.6e-06 27.8 47.4 0.022 15.6 3.4 6.6 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK69321.1 - 0.0087 16.5 0.2 0.0087 16.5 0.2 6.7 6 1 0 6 6 6 4 Zinc finger, C2H2 type PLAT PF01477.23 VDK69322.1 - 7.3e-16 58.8 0.1 1.2e-15 58.0 0.1 1.3 1 0 0 1 1 1 1 PLAT/LH2 domain ATS3 PF06232.11 VDK69322.1 - 2.6e-05 24.1 0.0 3.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Embryo-specific protein 3, (ATS3) Bin3 PF06859.12 VDK69324.1 - 4.3e-40 136.7 0.0 7.9e-40 135.9 0.0 1.5 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_12 PF08242.12 VDK69324.1 - 7.5e-12 45.9 0.0 5e-11 43.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK69324.1 - 1e-11 44.9 0.0 1.7e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK69324.1 - 1.2e-10 42.0 0.0 6.6e-06 26.8 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 VDK69324.1 - 3.9e-09 36.5 0.0 1e-07 31.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK69324.1 - 8.8e-09 35.9 0.0 0.0014 19.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 VDK69324.1 - 1.3e-06 28.1 0.0 4e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.7 VDK69324.1 - 2e-05 24.6 0.0 6.5e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 VDK69324.1 - 6.9e-05 22.4 0.0 0.00037 20.0 0.0 2.2 3 0 0 3 3 3 1 Putative methyltransferase CMAS PF02353.20 VDK69324.1 - 9e-05 21.9 0.0 0.24 10.7 0.0 2.2 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase PrmA PF06325.13 VDK69324.1 - 0.00021 20.8 0.0 0.00082 18.9 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 VDK69324.1 - 0.00021 21.1 0.0 0.0004 20.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 VDK69324.1 - 0.00055 19.0 0.0 0.0032 16.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) Spermine_synth PF01564.17 VDK69324.1 - 0.00085 18.8 0.1 0.77 9.1 0.0 2.2 2 0 0 2 2 2 2 Spermine/spermidine synthase domain Methyltransf_32 PF13679.6 VDK69324.1 - 0.0012 18.8 1.9 0.0017 18.4 0.0 2.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 VDK69324.1 - 0.0025 17.2 0.0 0.2 10.9 0.0 2.3 2 0 0 2 2 2 1 O-methyltransferase domain Met_10 PF02475.16 VDK69324.1 - 0.018 14.8 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein RrnaAD PF00398.20 VDK69324.1 - 0.13 11.3 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase UCH PF00443.29 VDK69326.1 - 2.9e-41 141.7 0.0 5.1e-41 140.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK69326.1 - 1.9e-05 24.4 0.2 0.028 14.0 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Nyv1_N PF09426.10 VDK69326.1 - 0.034 14.1 0.1 0.081 12.9 0.1 1.5 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal TPT PF03151.16 VDK69328.1 - 4.1e-12 46.0 13.4 4.8e-12 45.8 13.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 VDK69328.1 - 0.00063 19.9 19.2 0.079 13.1 6.2 2.3 2 0 0 2 2 2 2 EamA-like transporter family DENN PF02141.21 VDK69329.1 - 9.1e-45 152.9 4.4 1.9e-44 151.8 4.4 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain RUN PF02759.19 VDK69329.1 - 1.6e-27 96.1 2.2 7.8e-14 51.8 0.1 3.7 3 0 0 3 3 3 3 RUN domain dDENN PF03455.19 VDK69329.1 - 1.5e-15 56.9 4.1 1.5e-15 56.9 4.1 2.1 2 0 0 2 2 2 1 dDENN domain PLAT PF01477.23 VDK69329.1 - 5.9e-10 39.7 0.0 1.1e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 PLAT/LH2 domain uDENN PF03456.18 VDK69329.1 - 1.5e-08 35.2 0.0 3.9e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 uDENN domain RRM_1 PF00076.22 VDK69330.1 - 2.7e-17 62.3 0.0 3.7e-17 61.9 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK69330.1 - 0.15 12.1 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif zf-C2H2 PF00096.26 VDK69332.1 - 8e-19 67.0 53.2 0.00076 19.8 1.0 8.0 8 0 0 8 8 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK69332.1 - 8e-11 41.9 2.7 1.8e-05 24.9 0.2 8.4 8 2 0 8 8 7 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK69332.1 - 3.9e-10 39.7 56.7 0.0047 17.7 0.1 8.1 8 0 0 8 8 7 6 C2H2-type zinc finger zf-C2H2_11 PF16622.5 VDK69332.1 - 6.5e-05 22.6 0.4 6.5e-05 22.6 0.4 5.7 6 0 0 6 6 5 3 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 VDK69332.1 - 0.01 16.1 2.1 0.16 12.3 0.2 6.5 7 0 0 7 7 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 VDK69332.1 - 0.016 15.5 23.2 0.12 12.7 0.5 4.3 1 1 3 4 4 4 0 C2H2-type zinc ribbon zf_C2H2_ZHX PF18387.1 VDK69332.1 - 0.018 14.7 2.0 0.018 14.7 2.0 5.1 3 1 3 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HE PF16278.5 VDK69332.1 - 0.025 15.0 23.3 4.1 7.9 0.2 5.8 2 1 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf_UBZ PF18439.1 VDK69332.1 - 0.078 12.6 28.6 5.1 6.8 0.4 6.9 7 0 0 7 7 7 0 Ubiquitin-Binding Zinc Finger CpXC PF14353.6 VDK69332.1 - 0.26 11.3 20.3 0.36 10.9 4.5 4.1 2 2 2 4 4 4 0 CpXC protein zf-C2H2_6 PF13912.6 VDK69332.1 - 0.74 9.9 40.1 0.42 10.7 0.3 7.3 7 0 0 7 7 6 0 C2H2-type zinc finger GAGA PF09237.11 VDK69332.1 - 1 9.2 9.4 2.2 8.2 0.1 3.5 3 1 0 3 3 3 0 GAGA factor zf-met PF12874.7 VDK69332.1 - 1.5 9.3 20.0 2 8.9 0.6 5.8 6 0 0 6 6 6 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 VDK69332.1 - 5.2 7.3 40.8 0.088 12.9 3.8 6.3 4 2 1 5 5 5 0 Zinc ribbon domain BTB PF00651.31 VDK69333.1 - 2.8e-24 85.5 0.0 4.7e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 VDK69333.1 - 0.005 16.9 0.0 0.059 13.5 0.0 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Acyl-CoA_dh_1 PF00441.24 VDK69334.1 - 1.1e-35 123.0 1.4 2.2e-35 122.1 0.1 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 VDK69334.1 - 2.4e-25 89.4 0.0 5.4e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 VDK69334.1 - 8.2e-25 86.8 0.1 1.5e-24 86.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 VDK69334.1 - 2.9e-13 50.2 0.0 1.3e-12 48.1 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Vps23_core PF09454.10 VDK69334.1 - 0.033 14.1 0.0 0.079 12.9 0.0 1.6 1 0 0 1 1 1 0 Vps23 core domain MaoC_dehydratas PF01575.19 VDK69335.1 - 6.5e-31 106.5 0.0 1.7e-30 105.1 0.0 1.7 2 0 0 2 2 2 1 MaoC like domain MaoC_dehydrat_N PF13452.6 VDK69335.1 - 8e-07 29.3 0.0 3.9e-05 23.8 0.0 2.6 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase EFF-AFF PF14884.6 VDK69336.1 - 2.6e-130 435.3 0.3 6e-109 364.8 0.1 2.1 2 0 0 2 2 2 2 Type I membrane glycoproteins cell-cell fusogen TPP_enzyme_M_2 PF16582.5 VDK69336.1 - 0.085 12.6 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Middle domain of thiamine pyrophosphate Globin PF00042.22 VDK69337.1 - 4.6e-05 23.9 0.0 7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Globin DUF3658 PF12395.8 VDK69337.1 - 0.062 13.2 0.1 0.46 10.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function Pro_isomerase PF00160.21 VDK69338.1 - 2.1e-49 167.8 0.1 2.4e-49 167.6 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PDEase_I PF00233.19 VDK69340.1 - 1.2e-65 221.6 0.9 4.2e-65 219.8 0.9 1.8 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Got1 PF04178.12 VDK69342.1 - 3.4e-16 59.7 14.1 1.3e-15 57.8 14.1 1.8 1 1 1 2 2 2 1 Got1/Sft2-like family MGC-24 PF05283.11 VDK69342.1 - 0.072 13.5 1.2 0.072 13.5 1.2 2.2 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF308 PF03729.13 VDK69342.1 - 1.2 9.5 26.0 0.15 12.4 14.7 2.9 1 1 1 2 2 2 0 Short repeat of unknown function (DUF308) Tcp11 PF05794.13 VDK69345.1 - 1.7e-91 307.6 6.6 1.9e-91 307.4 6.6 1.0 1 0 0 1 1 1 1 T-complex protein 11 HNOB PF07700.15 VDK69345.1 - 0.04 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Haem-NO-binding DNA_photolyase PF00875.18 VDK69347.1 - 5.3e-13 49.3 0.0 9.9e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase Sarcoglycan_1 PF04790.13 VDK69348.1 - 7e-64 215.7 0.0 8e-64 215.5 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF2345 PF10106.9 VDK69348.1 - 8.2e-06 25.8 0.1 1.4e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2345) wnt PF00110.19 VDK69390.1 - 2.2e-75 254.1 22.7 1.7e-74 251.2 22.7 1.9 1 1 0 1 1 1 1 wnt family RRM_1 PF00076.22 VDK69391.1 - 2.8e-17 62.3 0.6 7.9e-17 60.8 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK69391.1 - 0.00017 21.2 0.0 0.00021 20.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_6 PF13174.6 VDK69391.1 - 0.00094 19.7 0.9 0.0023 18.5 0.9 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat RRM_8 PF11835.8 VDK69391.1 - 0.094 12.9 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 RRM-like domain PC4 PF02229.16 VDK69392.1 - 1.8e-23 81.9 0.2 2.9e-23 81.2 0.2 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) OTU PF02338.19 VDK69393.1 - 4.2e-20 72.5 1.6 7.8e-20 71.7 0.0 2.1 2 1 0 2 2 2 1 OTU-like cysteine protease FliT PF05400.13 VDK69393.1 - 0.041 14.7 2.6 0.041 14.7 2.6 1.8 2 0 0 2 2 2 0 Flagellar protein FliT PepSY_2 PF13670.6 VDK69393.1 - 0.075 13.0 0.4 2.3 8.3 0.0 2.5 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Gluconate_2-dh3 PF13618.6 VDK69393.1 - 0.38 11.0 4.3 0.67 10.2 3.4 1.8 1 1 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 ELMO_CED12 PF04727.13 VDK69394.1 - 3e-34 118.7 1.1 4.6e-34 118.1 1.1 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family NEXCaM_BD PF16644.5 VDK69394.1 - 0.014 15.6 0.1 0.025 14.8 0.1 1.4 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin DUF5432 PF17497.2 VDK69394.1 - 0.19 11.9 1.8 0.23 11.6 0.2 2.1 2 1 0 2 2 2 0 Family of unknown function (DUF5432) ARGLU PF15346.6 VDK69395.1 - 7.5e-22 77.8 28.7 8.8e-22 77.6 28.7 1.0 1 0 0 1 1 1 1 Arginine and glutamate-rich 1 Exonuc_VII_L PF02601.15 VDK69395.1 - 0.042 13.4 11.6 0.051 13.1 11.6 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mit_ribos_Mrp51 PF11709.8 VDK69395.1 - 0.17 11.5 8.0 0.19 11.3 8.0 1.0 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit V_ATPase_I PF01496.19 VDK69395.1 - 0.77 7.6 10.8 0.83 7.5 10.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 VDK69395.1 - 0.95 8.5 17.1 1.2 8.1 17.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TSP_NTD PF17804.1 VDK69395.1 - 1.6 9.0 12.9 1.4 9.2 11.7 1.4 1 1 0 1 1 1 0 Tail specific protease N-terminal domain DUF4407 PF14362.6 VDK69395.1 - 2.6 7.3 8.8 3.3 7.0 8.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GBP_C PF02841.14 VDK69395.1 - 3.3 7.0 20.9 4.5 6.6 20.9 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain FapA PF03961.13 VDK69395.1 - 3.5 6.1 12.6 4 5.9 12.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Tho2 PF11262.8 VDK69395.1 - 4.7 6.3 11.4 6 6.0 11.4 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF2203 PF09969.9 VDK69395.1 - 4.8 7.9 11.4 2.7 8.7 9.5 1.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.13 VDK69395.1 - 5.1 6.2 10.3 5.7 6.1 10.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein HSP70 PF00012.20 VDK69395.1 - 6.5 4.8 13.5 7.4 4.6 13.5 1.0 1 0 0 1 1 1 0 Hsp70 protein Syntaxin-6_N PF09177.11 VDK69395.1 - 7.2 7.2 13.0 10 6.8 13.0 1.2 1 0 0 1 1 1 0 Syntaxin 6, N-terminal ALMT PF11744.8 VDK69395.1 - 8.7 5.0 9.2 9.7 4.9 9.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 VDK69396.1 - 0.57 8.4 7.6 0.71 8.1 7.6 1.1 1 0 0 1 1 1 0 CDC45-like protein COesterase PF00135.28 VDK69397.1 - 8.6e-145 483.5 0.0 1.1e-144 483.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 VDK69397.1 - 0.0015 18.5 0.1 0.0064 16.4 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold AChE_tetra PF08674.10 VDK69397.1 - 0.0041 16.8 7.3 0.011 15.4 7.3 1.7 1 0 0 1 1 1 1 Acetylcholinesterase tetramerisation domain Collagen PF01391.18 VDK69398.1 - 1.5e-226 732.5 775.3 3.2e-10 39.6 19.2 30.1 2 2 25 27 27 27 25 Collagen triple helix repeat (20 copies) C4 PF01413.19 VDK69398.1 - 5.2e-83 274.7 3.4 3.1e-44 149.9 0.2 2.1 2 0 0 2 2 2 2 C-terminal tandem repeated domain in type 4 procollagen RRM_7 PF16367.5 VDK69399.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif LMBR1 PF04791.16 VDK69399.1 - 0.39 9.6 0.6 0.34 9.8 0.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1840 PF08895.11 VDK69399.1 - 2.3 8.6 8.8 1.3 9.4 4.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) PSS PF03034.15 VDK69402.1 - 2.3e-102 342.4 19.9 3.5e-102 341.8 19.9 1.3 1 0 0 1 1 1 1 Phosphatidyl serine synthase tRNA-synt_1c PF00749.21 VDK69406.1 - 2.9e-89 299.1 0.0 3.9e-89 298.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Glyco_hydro_47 PF01532.20 VDK69408.1 - 6.4e-113 378.1 0.0 1.6e-112 376.8 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 VDK69408.1 - 1.8e-10 40.7 0.3 5.2e-10 39.2 0.1 1.9 2 0 0 2 2 2 1 PA domain VirB3 PF05101.13 VDK69408.1 - 1.9 8.7 7.2 6.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein DSPc PF00782.20 VDK69410.1 - 1.6e-19 70.0 0.2 2.7e-19 69.3 0.2 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK69410.1 - 5.9e-05 22.7 0.1 8.9e-05 22.2 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase HECT_2 PF09814.9 VDK69410.1 - 0.071 12.0 0.3 0.13 11.1 0.1 1.5 2 0 0 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Bestrophin PF01062.21 VDK69416.1 - 5.9e-47 160.5 5.3 1.7e-45 155.7 5.3 2.1 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Kelch_1 PF01344.25 VDK69417.1 - 2e-25 88.1 2.4 1.1e-06 28.1 0.1 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 VDK69417.1 - 1.8e-24 85.1 4.1 1.6e-05 25.0 0.0 6.6 5 2 1 6 6 6 5 Kelch motif Kelch_4 PF13418.6 VDK69417.1 - 2.6e-22 78.6 5.9 3.4e-05 23.7 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 VDK69417.1 - 3.9e-17 62.1 1.6 7e-06 26.2 0.0 6.5 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 VDK69417.1 - 9.2e-14 51.1 8.6 0.018 15.0 0.0 6.6 6 1 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 VDK69417.1 - 6e-10 38.7 8.1 0.28 11.2 0.0 6.5 6 1 0 6 6 6 3 Kelch motif DUF938 PF06080.12 VDK69419.1 - 3.1e-71 239.3 0.0 3.5e-71 239.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_4 PF02390.17 VDK69419.1 - 0.11 11.9 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase zf-C2H2_4 PF13894.6 VDK69421.1 - 2.6e-15 55.8 38.6 0.035 14.9 1.1 7.8 8 0 0 8 8 7 6 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK69421.1 - 2.8e-15 55.8 35.8 0.0032 17.8 0.1 7.2 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK69421.1 - 7.8e-06 26.1 26.4 0.0016 18.8 0.2 7.5 8 0 0 8 8 7 1 Zinc-finger double domain zf-C2HC_2 PF13913.6 VDK69421.1 - 6.2e-05 22.8 0.0 0.0002 21.2 0.0 5.8 7 0 0 7 7 7 2 zinc-finger of a C2HC-type CpXC PF14353.6 VDK69421.1 - 0.00018 21.5 11.8 0.044 13.8 0.2 5.4 4 1 1 5 5 5 1 CpXC protein zf-met PF12874.7 VDK69421.1 - 0.00089 19.6 21.8 0.87 10.1 0.0 6.3 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK69421.1 - 0.001 19.3 20.6 2.4 8.5 0.1 6.5 6 0 0 6 6 6 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 VDK69421.1 - 0.0024 17.6 1.7 0.39 10.5 0.0 3.9 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 VDK69421.1 - 0.0053 17.1 16.9 15 6.0 0.3 6.6 4 3 3 7 7 7 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 VDK69421.1 - 0.007 16.6 21.9 0.11 12.8 2.4 5.0 4 1 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_12 PF18658.1 VDK69421.1 - 0.014 15.0 2.2 5.6 6.6 0.0 3.2 3 0 0 3 3 3 0 Zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 VDK69421.1 - 0.039 14.6 11.2 1.4 9.6 0.1 4.1 5 0 0 5 5 4 0 Zinc finger C2H2-type, 3 repeats zinc_ribbon_15 PF17032.5 VDK69421.1 - 0.066 14.0 6.1 10 6.9 0.1 3.9 4 0 0 4 4 3 0 zinc-ribbon family DUF2072 PF09845.9 VDK69421.1 - 0.14 12.4 0.4 6.2 7.1 0.0 3.6 3 0 0 3 3 3 0 Zn-ribbon containing protein GAGA PF09237.11 VDK69421.1 - 0.16 11.8 2.8 26 4.7 0.0 3.9 3 1 1 4 4 4 0 GAGA factor Zn-C2H2_12 PF18112.1 VDK69421.1 - 0.92 10.0 20.6 3.5 8.2 0.1 6.5 7 0 0 7 7 7 0 Autophagy receptor zinc finger-C2H2 domain Vps36-NZF-N PF16988.5 VDK69421.1 - 1.8 8.1 5.5 1.9 8.0 0.1 3.3 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Mss51 PF13824.6 VDK69421.1 - 3.5 7.8 6.8 14 5.9 0.0 4.0 3 1 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-3CxxC_2 PF17180.4 VDK69421.1 - 4.5 8.1 11.2 4.8 8.0 0.1 4.3 4 1 0 4 4 4 0 Zinc-binding domain zf-C2H2_9 PF16293.5 VDK69421.1 - 7.2 6.5 7.4 53 3.8 0.0 4.3 4 0 0 4 4 3 0 C2H2 type zinc-finger (1 copy) zf-met2 PF12907.7 VDK69421.1 - 8.6 6.6 11.4 4.1 7.6 0.7 3.7 4 0 0 4 4 4 0 Zinc-binding CBFD_NFYB_HMF PF00808.23 VDK69422.1 - 1.3e-10 41.3 0.0 2.4e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK69422.1 - 1.1e-05 25.8 0.0 1.5e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 DUF4318 PF14201.6 VDK69422.1 - 0.059 13.9 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4318) AMP-binding PF00501.28 VDK69423.1 - 6.5e-88 295.1 0.0 1.2e-87 294.3 0.0 1.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 VDK69423.1 - 2.2e-15 57.4 0.0 4.8e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DHHC PF01529.20 VDK69424.1 - 1.1e-35 122.7 17.1 1.1e-35 122.7 17.1 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase DUF1122 PF06557.11 VDK69424.1 - 0.0036 16.7 0.7 0.0064 15.9 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1122) DUF5056 PF16479.5 VDK69424.1 - 0.12 12.7 0.2 0.12 12.7 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5056) F-box PF00646.33 VDK69425.1 - 2.4e-06 27.3 0.0 7e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 VDK69425.1 - 1.5e-05 24.7 0.8 5e-05 23.1 0.8 2.0 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 VDK69425.1 - 0.0026 18.1 0.1 13 6.4 0.0 4.2 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) F-box_4 PF15966.5 VDK69425.1 - 0.0043 16.9 0.5 0.0083 16.0 0.0 1.7 2 0 0 2 2 2 1 F-box LRR_1 PF00560.33 VDK69425.1 - 0.025 15.1 0.5 17 6.4 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 VDK69425.1 - 0.092 12.8 0.5 12 6.3 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich repeat LRR_8 PF13855.6 VDK69425.1 - 0.19 11.5 2.3 5.1 6.9 0.0 3.9 5 0 0 5 5 5 0 Leucine rich repeat SLAC1 PF03595.17 VDK69426.1 - 0.0074 15.6 1.8 0.0099 15.2 1.8 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF3772 PF12607.8 VDK69426.1 - 0.043 13.6 0.9 0.083 12.7 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Peptidase_M14 PF00246.24 VDK69428.1 - 2.4e-67 227.8 0.0 4.1e-67 227.0 0.0 1.3 1 0 0 1 1 1 1 Zinc carboxypeptidase CarbopepD_reg_2 PF13715.6 VDK69428.1 - 1.5e-06 28.1 0.1 2.3e-05 24.3 0.0 2.6 3 0 0 3 3 3 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 VDK69428.1 - 0.0055 15.8 0.1 0.011 14.8 0.1 1.5 1 1 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family Renin_r PF07850.14 VDK69432.1 - 4.2e-26 91.4 2.0 1e-25 90.2 0.2 2.1 2 0 0 2 2 2 1 Renin receptor-like protein Nse4_C PF08743.10 VDK69432.1 - 0.011 15.9 0.3 0.025 14.8 0.2 1.6 1 1 0 1 1 1 0 Nse4 C-terminal Ribosomal_S14 PF00253.21 VDK69434.1 - 2.8e-12 46.2 1.3 7.1e-12 44.9 0.8 2.0 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e DNA_binding_1 PF01035.20 VDK69434.1 - 0.14 12.3 0.0 0.37 10.9 0.0 1.8 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, DNA binding domain WD40 PF00400.32 VDK69435.1 - 2e-28 98.0 6.8 6.6e-05 23.6 0.3 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK69435.1 - 1.5e-06 28.4 0.1 1.8 8.9 0.0 4.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 VDK69435.1 - 0.0073 16.8 0.0 0.68 10.5 0.0 3.3 3 0 0 3 3 3 1 PQQ-like domain WD40_like PF17005.5 VDK69435.1 - 0.0078 15.6 0.0 0.031 13.6 0.0 1.8 1 1 0 2 2 2 1 WD40-like domain Glyco_hydro_17 PF00332.18 VDK69435.1 - 0.02 14.5 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 17 Iso_dh PF00180.20 VDK69436.1 - 5.2e-65 219.9 0.1 6.1e-65 219.6 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase SPRY PF00622.28 VDK69437.1 - 1e-15 57.9 0.0 2e-15 57.0 0.0 1.4 2 0 0 2 2 2 1 SPRY domain adh_short PF00106.25 VDK69438.1 - 2.9e-38 131.3 0.0 3.8e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK69438.1 - 2.7e-23 82.8 0.0 3.7e-23 82.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK69438.1 - 5.4e-07 29.7 0.0 8.6e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 VDK69438.1 - 0.0022 17.4 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 VDK69438.1 - 0.0041 16.6 0.1 1.9 7.8 0.0 2.9 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 VDK69438.1 - 0.041 13.3 0.1 0.37 10.2 0.1 2.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 VDK69439.1 - 4.2e-17 62.3 0.0 1.3e-15 57.3 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 VDK69439.1 - 1.3e-08 34.7 0.0 1.9e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PseudoU_synth_2 PF00849.22 VDK69490.1 - 4.9e-25 88.5 0.0 8.8e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase ADK PF00406.22 VDK69491.1 - 2.9e-44 150.8 0.0 3.5e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 VDK69491.1 - 2.8e-33 115.2 0.0 4.2e-33 114.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 VDK69491.1 - 1.9e-12 47.8 0.1 5.5e-12 46.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 VDK69491.1 - 1.4e-05 25.3 0.0 2.5e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 VDK69491.1 - 0.005 16.7 0.8 0.14 12.0 0.2 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase Rad17 PF03215.15 VDK69491.1 - 0.0073 16.2 0.3 0.013 15.4 0.3 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain Thymidylate_kin PF02223.17 VDK69491.1 - 0.009 15.7 0.1 0.35 10.5 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase Cytidylate_kin PF02224.18 VDK69491.1 - 0.014 15.1 0.0 0.033 13.9 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase Zeta_toxin PF06414.12 VDK69491.1 - 0.04 13.2 0.0 0.063 12.6 0.0 1.5 1 1 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 VDK69491.1 - 0.056 13.7 0.0 0.092 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 VDK69491.1 - 0.093 13.2 0.2 0.13 12.6 0.3 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 VDK69491.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 NTPase ETC_C1_NDUFA5 PF04716.14 VDK69492.1 - 2e-21 75.5 0.5 5.1e-21 74.3 0.5 1.7 1 0 0 1 1 1 1 ETC complex I subunit conserved region LSM PF01423.22 VDK69492.1 - 7e-14 51.3 0.3 1.1e-13 50.6 0.3 1.4 1 0 0 1 1 1 1 LSM domain YCII PF03795.14 VDK69492.1 - 0.17 12.3 0.0 0.6 10.6 0.0 1.9 2 0 0 2 2 2 0 YCII-related domain Glyco_hydro_56 PF01630.18 VDK69494.1 - 1.1e-85 287.6 2.5 1.5e-85 287.2 2.5 1.0 1 0 0 1 1 1 1 Hyaluronidase PFU PF09070.11 VDK69495.1 - 1.2e-28 99.7 0.2 5.9e-15 55.5 0.0 2.7 2 0 0 2 2 2 2 PFU (PLAA family ubiquitin binding) PUL PF08324.11 VDK69495.1 - 2.7e-21 76.0 0.2 4.6e-21 75.3 0.2 1.3 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 VDK69495.1 - 5.7e-14 52.3 5.1 0.0046 17.8 0.1 7.4 7 0 0 7 7 7 4 WD domain, G-beta repeat BBS2_Mid PF14783.6 VDK69495.1 - 0.00065 19.7 0.1 0.39 10.8 0.0 3.5 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region YolD PF08863.10 VDK69495.1 - 0.056 13.5 0.0 0.35 11.0 0.0 2.3 2 0 0 2 2 2 0 YolD-like protein HEAT_2 PF13646.6 VDK69495.1 - 0.063 13.7 0.3 0.23 11.9 0.4 2.0 2 0 0 2 2 2 0 HEAT repeats DUF1214 PF06742.11 VDK69495.1 - 0.065 13.7 0.0 3.7 8.0 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1214) DUF2833 PF11090.8 VDK69495.1 - 0.11 12.9 0.0 27 5.2 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2833) DUF3449 PF11931.8 VDK69496.1 - 5.2e-75 251.3 0.7 1.1e-74 250.2 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 VDK69496.1 - 3.5e-26 91.5 2.8 7.8e-26 90.4 0.5 2.7 3 0 0 3 3 3 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Telomere_Sde2_2 PF13297.6 VDK69496.1 - 6.1e-26 89.8 3.7 1.4e-25 88.7 3.7 1.7 1 0 0 1 1 1 1 Telomere stability C-terminal SF3a60_bindingd PF12108.8 VDK69496.1 - 6.4e-12 45.1 0.0 1.5e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_4 PF13894.6 VDK69496.1 - 0.037 14.9 0.1 0.15 12.9 0.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger DUF148 PF02520.17 VDK69496.1 - 0.4 10.8 5.1 2.7 8.2 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function DUF148 NARG2_C PF10505.9 VDK69498.1 - 1.2e-18 67.4 0.1 2.6e-18 66.4 0.1 1.5 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus PAS_6 PF08348.11 VDK69498.1 - 0.0077 16.1 3.2 0.56 10.1 0.2 3.0 3 0 0 3 3 3 2 YheO-like PAS domain Cys_rich_KTR PF14205.6 VDK69498.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR An_peroxidase PF03098.15 VDK69501.1 - 3.8e-168 560.4 0.0 4.3e-168 560.2 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase INCENP_ARK-bind PF03941.15 VDK69503.1 - 4e-10 39.5 1.5 7.5e-10 38.6 0.2 2.1 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region UBA_4 PF14555.6 VDK69507.1 - 1.4e-06 28.0 1.3 4.3e-06 26.5 1.3 1.8 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 VDK69507.1 - 1.3e-05 25.3 0.0 3.4e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 UBX domain AAA_23 PF13476.6 VDK69507.1 - 0.093 13.2 7.6 0.19 12.2 7.6 1.6 1 0 0 1 1 1 0 AAA domain DUF874 PF05917.11 VDK69507.1 - 2.1 7.3 10.4 3.1 6.8 10.4 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) DDRGK PF09756.9 VDK69507.1 - 5.3 6.6 23.9 8.3 5.9 23.9 1.3 1 0 0 1 1 1 0 DDRGK domain RR_TM4-6 PF06459.12 VDK69507.1 - 5.7 6.7 10.8 10 5.8 10.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RCC1 PF00415.18 VDK69508.1 - 7.3e-41 138.6 1.9 1.2e-07 32.3 0.0 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 VDK69508.1 - 1.9e-27 94.4 27.0 1.1e-07 31.4 0.0 7.2 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat CRAL_TRIO_2 PF13716.6 VDK69511.1 - 5.5e-40 136.7 0.9 4e-37 127.4 2.0 2.4 2 0 0 2 2 2 2 Divergent CRAL/TRIO domain RhoGAP PF00620.27 VDK69511.1 - 4.8e-36 123.9 0.0 8.3e-36 123.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain CRAL_TRIO PF00650.20 VDK69511.1 - 3.9e-09 36.4 2.3 8.6e-09 35.3 1.2 2.1 2 1 0 2 2 2 1 CRAL/TRIO domain EF-hand_1 PF00036.32 VDK69512.1 - 6.3e-07 28.5 0.2 0.00038 19.8 0.0 3.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 VDK69512.1 - 9.1e-06 25.2 0.0 0.00091 19.0 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 VDK69512.1 - 3.6e-05 24.1 0.4 0.0064 16.9 0.0 3.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 VDK69512.1 - 0.003 17.0 0.4 0.015 14.8 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 VDK69512.1 - 0.05 13.5 6.2 0.094 12.6 0.3 3.3 3 1 0 3 3 3 0 EF-hand domain pair LIM PF00412.22 VDK69513.1 - 8.3e-06 25.9 2.0 1.4e-05 25.2 2.0 1.4 1 1 0 1 1 1 1 LIM domain Glyoxalase PF00903.25 VDK69514.1 - 6.6e-22 78.1 0.0 7.9e-22 77.8 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 VDK69514.1 - 1.5e-06 28.4 0.0 7.3e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 VDK69514.1 - 3.1e-05 24.7 0.0 6.6e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Guanylate_cyc PF00211.20 VDK69516.1 - 1.1e-63 214.1 0.0 2.2e-63 213.2 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 VDK69516.1 - 2.8e-46 158.3 0.7 4.4e-46 157.6 0.7 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_Tyr PF07714.17 VDK69516.1 - 1.1e-31 110.1 0.2 3.5e-31 108.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 VDK69516.1 - 7.1e-23 81.3 0.2 1.7e-22 80.0 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 VDK69516.1 - 0.00063 19.2 3.5 0.0012 18.4 3.5 1.4 1 0 0 1 1 1 1 Heme NO binding associated DSPc PF00782.20 VDK69519.1 - 6.8e-42 142.4 0.0 2.9e-41 140.4 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 VDK69519.1 - 0.11 12.6 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate UCH PF00443.29 VDK69523.1 - 1.3e-59 201.8 2.4 1.7e-59 201.4 2.4 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK69523.1 - 1.5e-19 70.8 10.7 4.7e-19 69.1 10.7 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 VDK69523.1 - 1.4e-06 28.5 15.5 1.4e-06 28.5 15.5 3.1 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_C98 PF15499.6 VDK69523.1 - 0.0056 16.2 0.1 0.0056 16.2 0.1 4.2 4 2 0 4 4 4 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Papo_T_antigen PF02380.15 VDK69523.1 - 0.062 13.4 0.2 0.062 13.4 0.2 4.4 5 0 0 5 5 5 0 T-antigen specific domain zf-ACC PF17848.1 VDK69523.1 - 0.13 12.4 0.3 0.13 12.4 0.3 4.0 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain DnaJ_C PF01556.18 VDK69525.1 - 8.5e-35 120.0 0.5 1.2e-34 119.5 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 VDK69525.1 - 1.6e-24 85.8 2.0 1.6e-24 85.8 2.0 1.6 2 0 0 2 2 2 1 DnaJ domain eIF2A PF08662.11 VDK69527.1 - 2e-06 27.8 0.4 0.13 12.1 0.0 3.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 VDK69527.1 - 6e-05 22.8 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Homeodomain PF00046.29 VDK69586.1 - 5.1e-22 77.5 4.2 7.8e-22 76.9 4.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK69586.1 - 0.023 14.6 0.1 0.055 13.4 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain Homez PF11569.8 VDK69586.1 - 0.17 11.4 1.5 0.37 10.3 1.5 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Spermine_synth PF01564.17 VDK69587.1 - 7.8e-07 28.7 1.1 1.2e-06 28.1 0.9 1.4 1 1 0 1 1 1 1 Spermine/spermidine synthase domain PCMT PF01135.19 VDK69587.1 - 1.6e-06 28.0 0.0 2.4e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 VDK69587.1 - 0.00011 22.8 0.0 0.00022 21.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK69587.1 - 0.0029 17.4 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 VDK69587.1 - 0.0076 15.3 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Cons_hypoth95 PF03602.15 VDK69587.1 - 0.024 14.3 0.1 0.04 13.5 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_31 PF13847.6 VDK69587.1 - 0.027 14.3 1.4 0.068 13.0 1.4 1.7 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 VDK69587.1 - 0.041 13.4 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_17 PF12692.7 VDK69587.1 - 0.093 12.7 0.0 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 S-adenosyl-L-methionine methyltransferase CHAT PF12770.7 VDK69587.1 - 0.17 11.3 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 CHAT domain NADH-UOR_E PF16514.5 VDK69587.1 - 1.4 9.3 4.8 0.27 11.6 0.4 2.1 3 0 0 3 3 2 0 putative NADH-ubiquinone oxidoreductase chain E Ribosomal_S18 PF01084.20 VDK69588.1 - 3.3e-05 24.0 0.0 6.7e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 PRP1_N PF06424.12 VDK69589.1 - 1.9e-41 141.9 6.7 1.9e-41 141.9 6.7 3.7 3 1 0 3 3 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 VDK69589.1 - 9.7e-30 100.7 32.8 0.00074 20.1 0.1 14.4 3 2 12 15 15 15 9 Tetratricopeptide repeat TPR_19 PF14559.6 VDK69589.1 - 4.8e-19 68.6 15.6 7e-06 26.5 0.1 8.9 7 2 3 10 10 10 5 Tetratricopeptide repeat TPR_2 PF07719.17 VDK69589.1 - 1.8e-12 46.4 18.5 0.0024 17.9 0.0 10.2 12 0 0 12 12 10 4 Tetratricopeptide repeat TPR_17 PF13431.6 VDK69589.1 - 6.5e-12 45.0 0.3 3.9 8.1 0.0 10.0 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK69589.1 - 2.4e-09 37.7 9.8 2.4 8.9 0.0 8.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK69589.1 - 1.9e-08 33.8 3.5 0.011 15.6 0.0 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK69589.1 - 2e-08 33.8 10.2 0.39 11.1 0.1 8.4 7 1 1 8 8 8 2 Tetratricopeptide repeat DUF3808 PF10300.9 VDK69589.1 - 0.0012 17.7 1.5 0.5 9.0 0.1 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF3808) TPR_9 PF13371.6 VDK69589.1 - 0.0028 17.7 6.4 1.6 8.9 0.0 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat Suf PF05843.14 VDK69589.1 - 0.0031 17.5 1.7 5.2 7.0 0.1 3.8 3 1 1 4 4 3 1 Suppressor of forked protein (Suf) TPR_12 PF13424.6 VDK69589.1 - 0.0051 17.1 18.9 0.36 11.2 0.0 7.1 6 3 1 7 7 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 VDK69589.1 - 0.013 15.5 0.3 5.6 7.1 0.0 3.8 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.10 VDK69589.1 - 0.025 13.6 4.4 0.032 13.3 0.1 3.0 3 2 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_11 PF13414.6 VDK69589.1 - 0.027 14.1 0.0 25 4.6 0.0 5.1 6 0 0 6 6 6 0 TPR repeat DUF4300 PF14133.6 VDK69589.1 - 0.042 13.5 0.0 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) TPR_6 PF13174.6 VDK69589.1 - 0.082 13.6 15.5 17 6.3 0.0 8.4 11 1 0 11 11 9 0 Tetratricopeptide repeat DUF410 PF04190.13 VDK69589.1 - 0.082 12.7 0.2 1.7 8.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF410) ZNRF_3_ecto PF18212.1 VDK69589.1 - 0.089 12.8 0.0 1.9 8.5 0.0 2.8 2 0 0 2 2 2 0 ZNRF-3 Ectodomain Cactin_mid PF10312.9 VDK69590.1 - 9.8e-49 165.8 2.4 9.8e-49 165.8 2.4 2.9 2 0 0 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.9 VDK69590.1 - 6.9e-48 161.7 1.7 1.9e-47 160.3 1.7 1.7 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein GTP_EFTU PF00009.27 VDK69592.1 - 8e-58 195.2 0.2 1.9e-57 193.9 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 VDK69592.1 - 5.9e-36 122.9 0.5 2.5e-35 120.9 0.0 2.3 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 VDK69592.1 - 2.3e-27 94.9 0.0 5.7e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 VDK69592.1 - 4.4e-21 74.7 0.0 1.2e-20 73.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 VDK69592.1 - 5.1e-11 42.8 0.0 2.7e-10 40.5 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 VDK69592.1 - 1.5e-05 24.8 0.0 4.9e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 VDK69592.1 - 0.0047 17.0 0.0 0.019 15.0 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase AvrPtoB_bdg PF16847.5 VDK69592.1 - 0.0096 16.4 0.0 0.23 11.9 0.0 2.6 2 0 0 2 2 2 1 Avirulence AvrPtoB, BAK1-binding domain AIG1 PF04548.16 VDK69592.1 - 0.011 15.1 0.3 0.031 13.6 0.0 1.8 2 0 0 2 2 2 0 AIG1 family DUF442 PF04273.13 VDK69592.1 - 0.012 15.7 0.0 3.9 7.6 0.0 2.6 2 0 0 2 2 2 0 Putative phosphatase (DUF442) Zw10 PF06248.13 VDK69593.1 - 2.6e-67 227.6 10.4 3.9e-67 227.1 10.4 1.1 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 EAP30 PF04157.16 VDK69593.1 - 0.017 14.4 0.0 4.1 6.6 0.0 3.6 2 1 0 3 3 3 0 EAP30/Vps36 family COG2 PF06148.11 VDK69593.1 - 0.31 11.1 3.4 0.43 10.7 0.2 3.0 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 MADF_DNA_bdg PF10545.9 VDK69594.1 - 3e-16 59.5 1.5 6.3e-16 58.5 1.5 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Lin-8 PF03353.15 VDK69594.1 - 0.035 13.7 0.1 0.035 13.7 0.1 2.0 3 0 0 3 3 3 0 Ras-mediated vulval-induction antagonist E2F_TDP PF02319.20 VDK69595.1 - 8.2e-21 73.8 0.1 1.6e-20 72.9 0.1 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain E2F_CC-MB PF16421.5 VDK69595.1 - 6.5e-18 64.9 0.3 1.5e-17 63.7 0.3 1.7 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain Cytochrom_B562 PF07361.11 VDK69595.1 - 0.18 12.5 0.1 0.46 11.2 0.1 1.6 1 0 0 1 1 1 0 Cytochrome b562 Exonuc_VII_S PF02609.16 VDK69595.1 - 1.4 9.0 3.6 3.1 7.9 3.6 1.5 1 0 0 1 1 1 0 Exonuclease VII small subunit Activin_recp PF01064.23 VDK69596.1 - 0.013 16.6 7.8 0.02 16.0 7.8 1.3 1 0 0 1 1 1 0 Activin types I and II receptor domain QVR PF17064.5 VDK69596.1 - 2.3 8.5 8.8 1.8 8.9 5.8 2.4 1 1 1 2 2 2 0 Sleepless protein COesterase PF00135.28 VDK69598.1 - 2.7e-113 379.6 0.3 8.6e-113 377.9 0.3 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 VDK69598.1 - 7.3e-09 35.8 0.7 1.3e-07 31.8 0.7 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pkinase PF00069.25 VDK69599.1 - 1.1e-72 244.6 0.0 1.3e-72 244.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK69599.1 - 6.6e-38 130.5 0.0 8.6e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK69599.1 - 7.2e-09 35.4 0.0 2.5e-07 30.3 0.0 2.0 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDK69599.1 - 0.0022 16.8 0.0 0.0035 16.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 VDK69599.1 - 0.099 11.7 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 zf-RING_2 PF13639.6 VDK69600.1 - 1.1e-09 38.5 19.2 3.7e-09 36.8 7.2 3.0 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK69600.1 - 1.3e-09 37.7 8.7 1.3e-09 37.7 8.7 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK69600.1 - 4.2e-09 36.1 8.0 4.2e-09 36.1 8.0 3.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK69600.1 - 2.2e-06 27.9 23.8 5.8e-06 26.5 8.8 3.6 3 1 0 3 3 3 2 RING-H2 zinc finger domain PHD PF00628.29 VDK69600.1 - 4.6e-06 26.4 6.6 4.6e-06 26.4 6.6 3.5 2 2 0 2 2 1 1 PHD-finger zf-C3HC4_3 PF13920.6 VDK69600.1 - 1.7e-05 24.6 5.3 1.7e-05 24.6 5.3 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 VDK69600.1 - 8e-05 22.4 1.5 0.0002 21.2 1.5 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 VDK69600.1 - 8.5e-05 22.5 6.9 8.5e-05 22.5 6.9 2.4 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 VDK69600.1 - 0.00049 20.2 9.1 0.00049 20.2 9.1 2.9 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 VDK69600.1 - 0.0059 16.7 4.9 0.0059 16.7 4.9 2.6 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_5 PF14634.6 VDK69600.1 - 0.007 16.3 7.2 0.007 16.3 7.2 4.0 4 2 0 4 4 4 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 VDK69600.1 - 0.011 15.7 7.5 0.066 13.3 1.5 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 VDK69600.1 - 0.049 13.5 1.8 0.12 12.2 1.8 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 VDK69600.1 - 0.28 10.8 8.8 0.027 14.1 3.3 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 VDK69600.1 - 0.47 10.4 19.0 0.042 13.7 6.9 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 Prim_Zn_Ribbon PF08273.12 VDK69600.1 - 0.48 10.7 0.1 0.48 10.7 0.1 4.1 4 0 0 4 4 4 0 Zinc-binding domain of primase-helicase FANCL_C PF11793.8 VDK69600.1 - 0.49 10.6 15.1 1.6 8.9 3.3 3.4 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_11 PF17123.5 VDK69600.1 - 2.4 8.0 8.0 3.6 7.4 5.0 2.8 2 1 0 2 2 2 0 RING-like zinc finger U3_assoc_6 PF08640.11 VDK69601.1 - 3.3e-15 55.9 2.8 9.6e-15 54.4 0.9 2.5 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 VDK69601.1 - 1.6e-06 28.5 0.0 0.021 15.6 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat NRDE-2 PF08424.10 VDK69601.1 - 0.069 12.3 9.6 0.22 10.6 0.0 3.9 3 2 2 5 5 5 0 NRDE-2, necessary for RNA interference HCO3_cotransp PF00955.21 VDK69602.1 - 3e-185 616.9 15.0 3.9e-185 616.5 15.0 1.1 1 0 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 VDK69602.1 - 1.8e-34 119.8 0.1 3.1e-24 86.2 0.0 2.3 1 1 1 2 2 2 2 Band 3 cytoplasmic domain DNase_II PF03265.15 VDK69605.1 - 1.2e-99 333.7 2.2 1.3e-99 333.5 2.2 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II WD40 PF00400.32 VDK69609.1 - 3.8e-47 157.3 24.3 3.3e-09 37.2 0.0 8.4 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK69609.1 - 2.4e-24 85.4 1.9 1.2e-06 28.7 0.1 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 VDK69609.1 - 2.6e-08 33.5 0.1 6e-08 32.4 0.1 1.7 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 VDK69609.1 - 3.7e-07 29.8 0.3 0.063 12.6 0.0 3.7 3 1 0 3 3 3 2 WD40-like domain eIF2A PF08662.11 VDK69609.1 - 2.6e-06 27.4 0.7 0.0096 15.8 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 VDK69609.1 - 0.0065 15.2 1.9 0.16 10.5 0.0 3.3 3 1 1 4 4 4 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 VDK69609.1 - 0.011 14.7 0.3 4.3 6.2 0.0 3.5 2 1 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SIR4_SID PF16991.5 VDK69609.1 - 0.029 14.4 0.4 0.053 13.6 0.4 1.4 1 0 0 1 1 1 0 Sir4 SID domain PD40 PF07676.12 VDK69609.1 - 0.033 14.1 0.0 0.3 11.1 0.0 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 VDK69612.1 - 2e-12 47.4 3.8 3.4e-05 24.5 0.6 5.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK69612.1 - 2.2e-08 34.3 0.1 2.3 8.6 0.0 5.1 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 VDK69612.1 - 4e-05 23.3 0.0 0.059 12.9 0.0 2.5 2 1 0 2 2 2 2 PQQ-like domain CPSF_A PF03178.15 VDK69612.1 - 0.11 11.8 0.1 5.9 6.1 0.0 2.9 1 1 1 3 3 3 0 CPSF A subunit region 7tm_1 PF00001.21 VDK69613.1 - 1.4e-13 50.8 1.5 1.4e-13 50.8 1.5 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK69613.1 - 0.00068 19.1 1.4 0.00068 19.1 1.4 2.3 1 1 2 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srsx Lectin_N PF03954.14 VDK69613.1 - 0.034 13.9 3.6 0.049 13.4 3.3 1.5 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain zf-C2H2 PF00096.26 VDK69654.1 - 2.3e-12 46.6 59.2 0.01 16.3 0.1 9.2 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK69654.1 - 4.1e-10 39.6 66.6 0.088 13.7 1.6 9.9 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK69654.1 - 7.7e-05 22.9 6.1 0.00051 20.3 1.9 8.6 9 0 0 9 9 9 2 Zinc-finger double domain BTB PF00651.31 VDK69654.1 - 0.00072 19.8 0.0 0.0016 18.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_jaz PF12171.8 VDK69654.1 - 0.12 12.7 0.0 0.12 12.7 0.0 7.0 9 0 0 9 9 9 0 Zinc-finger double-stranded RNA-binding RNA_pol_Rbc25 PF08292.12 VDK69654.1 - 0.14 12.3 0.4 0.33 11.2 0.4 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 zf-C2H2_6 PF13912.6 VDK69654.1 - 0.19 11.8 34.2 3.1 7.9 0.9 7.8 7 0 0 7 7 7 0 C2H2-type zinc finger zf_UBZ PF18439.1 VDK69654.1 - 2.2 7.9 25.0 4.9 6.8 0.3 6.5 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger zf-met PF12874.7 VDK69654.1 - 5 7.7 26.9 0.72 10.3 0.4 6.9 7 0 0 7 7 7 0 Zinc-finger of C2H2 type MRG PF05712.13 VDK69658.1 - 3.6e-36 124.4 0.1 5.7e-36 123.7 0.1 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 VDK69658.1 - 2.8e-09 36.7 3.8 5.8e-09 35.7 0.3 2.4 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Tudor_2 PF18104.1 VDK69658.1 - 0.078 12.7 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain Chromo PF00385.24 VDK69658.1 - 0.12 12.3 0.2 0.33 10.9 0.2 1.8 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain ThiF PF00899.21 VDK69659.1 - 3.6e-66 223.0 0.2 5.9e-66 222.3 0.2 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 VDK69659.1 - 1.2e-10 41.4 0.1 2.6e-10 40.3 0.1 1.6 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 VDK69659.1 - 0.03 14.4 0.0 0.073 13.1 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ShK PF01549.24 VDK69661.1 - 5.2e-05 23.7 20.3 5.7e-05 23.6 4.3 3.2 3 0 0 3 3 3 2 ShK domain-like zf-RING_UBOX PF13445.6 VDK69661.1 - 0.37 10.9 4.7 1.8 8.7 4.7 2.3 1 0 0 1 1 1 0 RING-type zinc-finger Motile_Sperm PF00635.26 VDK69663.1 - 3e-17 62.4 0.2 6.6e-17 61.3 0.0 1.7 2 0 0 2 2 2 1 MSP (Major sperm protein) domain WD40 PF00400.32 VDK69665.1 - 1.4e-39 133.3 17.4 1e-07 32.5 0.3 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK69665.1 - 1.8e-19 69.8 6.4 0.0007 19.9 0.3 5.6 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK69665.1 - 0.021 13.8 0.1 8.2 5.3 0.1 3.4 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TTR-52 PF01060.23 VDK69665.1 - 0.039 14.7 0.0 0.095 13.4 0.0 1.6 1 0 0 1 1 1 0 Transthyretin-like family Ribosomal_L20 PF00453.18 VDK69666.1 - 2.5e-15 56.5 0.3 3.2e-15 56.1 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L20 DUF2087 PF09860.9 VDK69666.1 - 0.029 14.5 0.1 0.066 13.4 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) MADF_DNA_bdg PF10545.9 VDK69667.1 - 4.3e-42 142.3 10.1 2.6e-22 78.9 0.9 2.5 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK69667.1 - 2.5e-05 24.6 6.9 0.0012 19.1 1.1 2.5 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 VDK69667.1 - 0.0093 16.0 4.6 0.03 14.4 0.1 2.5 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain DUF573 PF04504.14 VDK69667.1 - 0.04 14.6 0.7 2.6 8.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF573 RNase_T PF00929.24 VDK69668.1 - 1.6e-23 84.1 0.0 1.8e-23 83.9 0.0 1.1 1 0 0 1 1 1 1 Exonuclease CDC37_M PF08565.11 VDK69669.1 - 2.3e-18 66.2 0.3 7.6e-18 64.5 0.3 1.9 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_N PF03234.14 VDK69669.1 - 2.1e-14 54.5 17.0 2.1e-14 54.5 17.0 2.4 2 2 0 2 2 2 1 Cdc37 N terminal kinase binding CDC37_C PF08564.10 VDK69669.1 - 3.4e-09 36.7 0.0 3.4e-09 36.7 0.0 2.9 2 1 0 2 2 2 1 Cdc37 C terminal domain Acyl_transf_3 PF01757.22 VDK69671.1 - 4e-13 49.2 45.6 5e-12 45.5 45.6 2.1 1 1 0 1 1 1 1 Acyltransferase family SLBP_RNA_bind PF15247.6 VDK69673.1 - 8.5e-20 70.7 7.0 8.5e-20 70.7 7.0 2.1 2 0 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain SPEG_u2 PF16650.5 VDK69673.1 - 0.093 12.9 1.5 0.54 10.5 0.2 2.8 2 0 0 2 2 2 0 Unstructured region on SPEG complex protein DUF1772 PF08592.11 VDK69676.1 - 0.0016 18.7 5.0 1.4 9.2 5.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) Cortexin PF11057.8 VDK69676.1 - 0.013 15.3 0.1 0.028 14.3 0.1 1.6 1 0 0 1 1 1 0 Cortexin of kidney MFS_1 PF07690.16 VDK69676.1 - 0.073 12.0 6.5 0.33 9.8 6.2 1.7 1 1 0 1 1 1 0 Major Facilitator Superfamily PMT_4TMC PF16192.5 VDK69676.1 - 0.21 11.2 5.1 0.26 10.8 5.1 1.2 1 0 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase EamA PF00892.20 VDK69676.1 - 0.27 11.4 11.6 0.83 9.8 3.4 2.1 1 1 1 2 2 2 0 EamA-like transporter family DUF2892 PF11127.8 VDK69676.1 - 0.42 10.7 3.3 0.2 11.7 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) EGF PF00008.27 VDK69678.1 - 1e-15 57.7 33.2 4.1e-07 30.2 4.0 3.7 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 VDK69678.1 - 1.2e-10 41.6 30.0 2e-06 28.2 3.8 4.3 3 0 0 3 3 3 3 Human growth factor-like EGF DUF1794 PF08768.11 VDK69678.1 - 5.3e-08 32.9 0.1 1.6e-07 31.4 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1794) ShK PF01549.24 VDK69678.1 - 1.8e-07 31.6 9.0 6.4e-07 29.8 9.0 2.0 1 0 0 1 1 1 1 ShK domain-like Reeler PF02014.16 VDK69678.1 - 8.1e-07 29.8 0.0 2.1e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 Reeler domain DRIM PF07539.12 VDK69680.1 - 2.4e-39 135.2 11.4 2.4e-39 135.2 11.4 2.7 3 1 0 3 3 3 1 Down-regulated in metastasis HEAT PF02985.22 VDK69680.1 - 0.00028 20.9 1.5 21 5.7 0.1 6.2 5 0 0 5 5 5 2 HEAT repeat Oscp1 PF10188.9 VDK69680.1 - 0.069 13.3 3.2 0.13 12.3 0.8 2.8 2 0 0 2 2 2 0 Organic solute transport protein 1 LRR_8 PF13855.6 VDK69681.1 - 6.9e-136 442.1 119.2 3.9e-13 49.0 0.9 18.7 11 4 6 19 19 19 19 Leucine rich repeat LRR_4 PF12799.7 VDK69681.1 - 8e-57 188.2 141.4 3.8e-06 27.2 0.1 22.6 11 4 13 25 25 25 22 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK69681.1 - 5.9e-48 162.0 35.3 1.1e-08 35.1 4.0 9.8 3 2 5 10 10 10 8 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 VDK69681.1 - 3.3e-21 75.6 76.3 5e-05 22.9 0.8 10.6 2 2 8 11 11 11 10 Leucine-rich repeat LRR_1 PF00560.33 VDK69681.1 - 2.6e-13 48.5 97.9 4 8.4 0.0 28.9 30 4 1 31 31 31 7 Leucine Rich Repeat LRR_6 PF13516.6 VDK69681.1 - 4.1e-09 35.8 96.4 0.76 10.0 0.4 24.9 29 0 0 29 29 29 7 Leucine Rich repeat NBD94 PF16830.5 VDK69681.1 - 0.075 13.4 14.4 1.7 9.1 0.6 5.4 5 0 0 5 5 5 0 Nucleotide-Binding Domain 94 of RH DRIM PF07539.12 VDK69683.1 - 1.4e-44 152.5 8.8 4.3e-42 144.3 0.1 4.0 4 0 0 4 4 4 4 Down-regulated in metastasis zf-U11-48K PF05253.12 VDK69687.1 - 4.3 7.4 18.3 0.41 10.6 1.1 3.8 4 1 0 4 4 4 0 U11-48K-like CHHC zinc finger Pkinase PF00069.25 VDK69689.1 - 2.9e-43 148.1 0.0 5.7e-43 147.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK69689.1 - 3.3e-42 144.6 0.0 4.7e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK69689.1 - 0.00038 19.3 0.0 0.0008 18.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK69689.1 - 0.00072 19.0 0.1 0.0018 17.7 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_16 PF10294.9 VDK69690.1 - 6.4e-15 55.3 0.0 1.2e-14 54.4 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase BcrAD_BadFG PF01869.20 VDK69690.1 - 4.4e-14 52.6 0.0 6.6e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family zf-RING_5 PF14634.6 VDK69690.1 - 1.7e-06 27.9 9.7 4.7e-06 26.5 9.7 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 VDK69690.1 - 0.0067 16.7 8.9 0.0067 16.7 8.9 2.8 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK69690.1 - 0.0082 16.0 4.1 0.029 14.2 4.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK69690.1 - 0.16 11.9 14.7 0.021 14.7 9.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK69690.1 - 0.22 11.6 11.7 0.043 13.9 5.9 2.7 2 1 0 2 2 2 0 RING-type zinc-finger Prok-RING_4 PF14447.6 VDK69690.1 - 1.3 9.0 10.9 3.3 7.7 10.9 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Arv1 PF04161.13 VDK69692.1 - 7.3e-26 91.6 2.3 8.1e-26 91.5 2.3 1.0 1 0 0 1 1 1 1 Arv1-like family Arv1 PF04161.13 VDK69695.1 - 0.00027 21.2 3.7 0.00042 20.5 3.7 1.3 1 0 0 1 1 1 1 Arv1-like family DUF975 PF06161.11 VDK69695.1 - 0.011 15.6 7.4 0.012 15.4 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF975) DUF3087 PF11286.8 VDK69695.1 - 0.42 10.1 2.9 0.33 10.4 1.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3087) BHD_3 PF10405.9 VDK69697.1 - 6.6e-25 87.3 0.0 1.8e-24 85.9 0.0 1.8 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 Rad4 PF03835.15 VDK69697.1 - 2.9e-23 82.2 2.3 2.9e-23 82.2 2.3 2.8 3 0 0 3 3 3 1 Rad4 transglutaminase-like domain BHD_1 PF10403.9 VDK69697.1 - 1.6e-14 53.4 0.5 5.7e-14 51.7 0.5 2.0 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 VDK69697.1 - 5.9e-12 46.4 0.6 5.9e-12 46.4 0.6 2.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 I-set PF07679.16 VDK69697.1 - 5.3e-09 36.0 2.0 0.00096 19.2 0.0 2.9 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK69697.1 - 0.00012 22.6 0.0 0.067 13.8 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin domain DUF3979 PF13141.6 VDK69697.1 - 0.015 15.6 0.1 0.097 12.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3979) PCNA_N PF00705.18 VDK69698.1 - 8.6e-44 148.3 4.2 1.8e-43 147.3 4.2 1.5 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 VDK69698.1 - 1.7e-43 147.9 0.0 3.8e-43 146.7 0.0 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain 2OG-FeII_Oxy_2 PF13532.6 VDK69698.1 - 4.5e-34 118.4 0.0 8.4e-34 117.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Rad1 PF02144.16 VDK69698.1 - 8.9e-09 34.8 3.1 3.1e-08 33.0 1.0 2.4 2 1 0 2 2 2 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 VDK69698.1 - 0.00022 20.4 0.9 0.0029 16.8 0.2 2.6 2 1 1 3 3 3 1 Hus1-like protein Rad9 PF04139.13 VDK69698.1 - 0.0043 16.5 0.3 0.007 15.8 0.3 1.3 1 0 0 1 1 1 1 Rad9 CAS_C PF12026.8 VDK69723.1 - 0.078 13.1 0.2 0.17 11.9 0.2 1.6 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Herpes_BBRF1 PF04793.12 VDK69725.1 - 0.033 13.2 0.1 0.037 13.1 0.1 1.1 1 0 0 1 1 1 0 BRRF1-like protein Proteasome PF00227.26 VDK69729.1 - 2e-46 157.9 0.8 2.4e-46 157.6 0.8 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 VDK69729.1 - 0.00087 18.7 0.0 0.00087 18.7 0.0 1.8 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Pkinase PF00069.25 VDK69731.1 - 2.6e-48 164.7 0.0 3.3e-48 164.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK69731.1 - 8.1e-20 71.2 0.0 2.7e-19 69.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 VDK69731.1 - 0.027 13.8 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK69731.1 - 0.067 13.1 0.0 10 5.9 0.0 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family TMEM171 PF15471.6 VDK69733.1 - 0.01 14.9 0.1 0.011 14.7 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein family 171 S4 PF01479.25 VDK69733.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.3 1 0 0 1 1 1 0 S4 domain Mito_fiss_reg PF05308.11 VDK69733.1 - 0.047 13.8 1.7 0.048 13.7 1.7 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 VDK69733.1 - 0.29 11.2 8.4 0.41 10.7 8.4 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 VDK69733.1 - 0.62 9.5 7.6 0.74 9.2 7.6 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MFS_1 PF07690.16 VDK69735.1 - 1.5e-36 126.1 45.7 1.2e-20 73.8 7.0 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_1_like PF12832.7 VDK69735.1 - 0.0019 17.2 23.3 0.01 14.7 0.1 4.2 1 1 0 4 4 4 3 MFS_1 like family Pkinase_Tyr PF07714.17 VDK69738.1 - 1.2e-92 309.8 0.0 2.6e-92 308.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK69738.1 - 7.3e-44 150.1 0.0 1.7e-43 148.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK69738.1 - 1.4e-23 82.8 1.4 3.2e-23 81.6 1.4 1.7 1 0 0 1 1 1 1 SH2 domain F_actin_bind PF08919.10 VDK69738.1 - 1.8e-17 63.4 0.9 1.8e-17 63.4 0.9 2.7 2 0 0 2 2 2 1 F-actin binding SH3_1 PF00018.28 VDK69738.1 - 4.5e-11 42.2 0.0 1.1e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK69738.1 - 7.2e-08 32.2 0.1 2.4e-07 30.5 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 VDK69738.1 - 2.7e-07 30.2 0.0 6.1e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 VDK69738.1 - 0.0021 18.3 0.1 0.0048 17.2 0.1 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Kinase-like PF14531.6 VDK69738.1 - 0.043 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 VDK69738.1 - 0.047 12.6 0.0 0.12 11.2 0.0 1.7 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 VDK69738.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Picorna_P3A PF06363.11 VDK69738.1 - 0.12 12.2 0.2 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Picornaviridae P3A protein YkuD_2 PF13645.6 VDK69740.1 - 0.056 12.9 0.0 0.087 12.3 0.0 1.2 1 0 0 1 1 1 0 L,D-transpeptidase catalytic domain Phage_G PF02306.15 VDK69740.1 - 0.1 12.3 4.8 0.59 9.8 1.0 2.5 1 1 1 2 2 2 0 Major spike protein (G protein) TSC22 PF01166.18 VDK69741.1 - 3.5e-23 81.7 4.1 8.9e-23 80.4 4.1 1.8 1 1 0 1 1 1 1 TSC-22/dip/bun family SOGA PF11365.8 VDK69741.1 - 0.05 14.7 3.8 0.17 13.0 3.8 1.9 1 1 1 2 2 2 0 Protein SOGA Ribophorin_II PF05817.14 VDK69742.1 - 8.1e-190 632.5 5.9 9.8e-190 632.2 5.9 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Ly49 PF08391.10 VDK69743.1 - 2.7 8.4 6.2 0.57 10.5 0.6 2.1 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Ank_2 PF12796.7 VDK69745.1 - 4.8e-33 113.6 0.7 3.3e-18 66.1 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK69745.1 - 2.3e-23 82.3 1.4 1e-09 38.7 0.1 3.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK69745.1 - 5.1e-22 75.6 0.2 8e-06 25.8 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 VDK69745.1 - 4.5e-18 64.8 6.0 3.1e-07 30.5 0.0 4.5 4 1 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 VDK69745.1 - 1.8e-14 53.6 4.8 7.2e-06 26.2 0.5 4.5 2 1 2 4 4 4 4 Ankyrin repeats (many copies) DHHC PF01529.20 VDK69747.1 - 9.9e-27 93.7 14.2 9.9e-27 93.7 14.2 2.3 1 1 1 2 2 2 1 DHHC palmitoyltransferase B277 PF17623.2 VDK69747.1 - 0.051 12.7 0.0 0.078 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function CRAL_TRIO_N PF03765.15 VDK69749.1 - 0.076 13.2 0.1 0.61 10.3 0.0 2.0 2 0 0 2 2 2 0 CRAL/TRIO, N-terminal domain Ank_2 PF12796.7 VDK69752.1 - 1.2e-24 86.7 10.4 6.9e-08 33.0 0.2 4.1 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Patatin PF01734.22 VDK69752.1 - 2.4e-18 67.1 0.4 3e-17 63.5 0.4 2.4 1 1 0 1 1 1 1 Patatin-like phospholipase Ank PF00023.30 VDK69752.1 - 1.1e-16 60.5 7.2 5.5e-05 23.4 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 VDK69752.1 - 1.8e-16 60.2 3.6 2.6e-05 24.7 0.0 5.6 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK69752.1 - 1e-15 57.5 3.9 9.5e-08 32.2 0.1 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK69752.1 - 1.3e-12 46.7 2.4 0.013 16.0 0.0 6.5 6 0 0 6 6 6 3 Ankyrin repeat DUF719 PF05334.13 VDK69754.1 - 3.2e-14 53.6 0.4 3.2e-14 53.6 0.4 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF719) DREV PF05219.12 VDK69756.1 - 8.2e-74 248.0 0.0 9.6e-74 247.8 0.0 1.0 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_23 PF13489.6 VDK69756.1 - 7.6e-06 25.8 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK69756.1 - 0.094 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TLD PF07534.16 VDK69760.1 - 1.4e-13 51.2 0.1 3.5e-10 40.3 0.1 2.7 1 1 1 2 2 2 2 TLD RabGAP-TBC PF00566.18 VDK69760.1 - 3.3e-11 43.3 3.0 3.3e-11 43.3 3.0 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PQ-loop PF04193.14 VDK69762.1 - 1.5e-08 34.3 4.9 1.5e-08 34.3 4.9 1.9 3 0 0 3 3 3 1 PQ loop repeat PA28_alpha PF02251.18 VDK69762.1 - 0.046 13.8 0.2 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Proteasome activator pa28 alpha subunit ASFV_J13L PF05568.11 VDK69762.1 - 0.14 11.9 0.1 0.24 11.2 0.1 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein Tim29 PF10171.9 VDK69764.1 - 2.2e-38 131.4 0.9 2.6e-38 131.2 0.9 1.0 1 0 0 1 1 1 1 Translocase of the Inner Mitochondrial membrane 29 TAN PF11640.8 VDK69765.1 - 0.026 14.6 1.5 0.53 10.4 0.0 3.8 4 1 0 4 4 4 0 Telomere-length maintenance and DNA damage repair API5 PF05918.11 VDK69765.1 - 0.8 8.4 5.7 5.9 5.6 0.1 3.1 3 0 0 3 3 3 0 Apoptosis inhibitory protein 5 (API5) DUF3704 PF12488.8 VDK69798.1 - 0.11 12.2 1.1 5.7 6.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) PAP_assoc PF03828.19 VDK69799.1 - 6.6e-13 48.7 0.0 1.3e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 VDK69799.1 - 9.7e-10 38.6 0.1 1.7e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain BTB PF00651.31 VDK69802.1 - 3.1e-24 85.3 1.2 5.9e-23 81.2 0.3 2.6 2 1 1 3 3 3 1 BTB/POZ domain MATH PF00917.26 VDK69802.1 - 0.0017 18.5 0.4 0.0035 17.5 0.4 1.6 1 0 0 1 1 1 1 MATH domain HTH_45 PF14947.6 VDK69802.1 - 0.11 12.4 0.0 1.9 8.5 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DnaJ PF00226.31 VDK69803.1 - 3.4e-14 52.7 0.7 6.6e-14 51.8 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain Sec63 PF02889.16 VDK69803.1 - 4.1e-13 49.1 1.3 1.6e-07 30.8 0.2 2.4 2 1 0 2 2 2 2 Sec63 Brl domain DUF3493 PF11998.8 VDK69803.1 - 0.0021 18.2 0.0 0.0043 17.2 0.0 1.5 1 0 0 1 1 1 1 Low psii accumulation1 / Rep27 FNIP_N PF14636.6 VDK69803.1 - 0.43 11.5 5.2 0.9 10.5 5.2 1.4 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus Red1 PF07964.11 VDK69803.1 - 7.8 4.6 21.8 12 3.9 21.8 1.3 1 0 0 1 1 1 0 Rec10 / Red1 RRM_1 PF00076.22 VDK69804.1 - 0.0042 16.9 0.0 0.0078 16.0 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 VDK69805.1 - 3.5e-13 49.2 0.0 0.00038 20.2 0.0 4.0 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 VDK69808.1 - 2.4e-60 204.1 0.0 3.1e-60 203.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK69808.1 - 1.6e-36 125.9 0.0 8.3e-36 123.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK69808.1 - 0.00011 21.1 0.0 0.00018 20.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 VDK69808.1 - 0.00014 21.0 0.1 0.0002 20.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 VDK69808.1 - 0.0018 17.4 0.4 0.0027 16.8 0.4 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.22 VDK69808.1 - 0.2 11.2 1.1 0.49 10.0 0.0 2.1 3 0 0 3 3 3 0 RIO1 family LTV PF04180.14 VDK69811.1 - 9.1e-19 68.4 22.2 4.5e-09 36.5 6.4 3.0 1 1 1 2 2 2 2 Low temperature viability protein Herpes_UL56 PF04534.12 VDK69811.1 - 0.7 9.3 3.3 1.1 8.7 3.3 1.2 1 0 0 1 1 1 0 Herpesvirus UL56 protein Peptidase_M14 PF00246.24 VDK69815.1 - 8.8e-79 265.3 0.1 3.9e-77 259.9 0.0 2.3 2 0 0 2 2 2 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 VDK69815.1 - 7.2e-19 67.8 1.5 1.2e-12 47.9 0.0 3.1 3 0 0 3 3 3 2 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 VDK69815.1 - 5.7e-07 29.4 2.0 0.00012 22.0 0.1 2.6 2 0 0 2 2 2 2 CarboxypepD_reg-like domain DUF2846 PF11008.8 VDK69815.1 - 0.015 15.3 0.1 2.9 8.0 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2846) Filamin PF00630.19 VDK69817.1 - 8.9e-121 395.9 20.0 2.5e-14 53.9 0.0 14.7 13 1 1 14 14 14 13 Filamin/ABP280 repeat CH PF00307.31 VDK69817.1 - 4.5e-34 116.9 1.3 1.2e-18 67.3 1.3 2.6 2 0 0 2 2 2 2 Calponin homology (CH) domain Invasin_D3 PF09134.10 VDK69817.1 - 7.2e-06 26.2 3.5 0.25 11.7 0.0 5.6 6 0 0 6 6 6 2 Invasin, domain 3 Y_Y_Y PF07495.13 VDK69817.1 - 0.0001 22.2 6.0 2.4 8.2 0.0 6.7 8 0 0 8 8 8 2 Y_Y_Y domain CAMSAP_CH PF11971.8 VDK69817.1 - 0.0077 16.0 0.0 7.2 6.5 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain PapC_N PF13954.6 VDK69817.1 - 0.016 15.3 0.0 3.9 7.5 0.0 4.3 4 1 0 4 4 4 0 PapC N-terminal domain Big_3_5 PF16640.5 VDK69817.1 - 0.03 14.5 4.5 4.5 7.5 0.0 5.4 6 0 0 6 6 6 0 Bacterial Ig-like domain (group 3) DUF5060 PF16586.5 VDK69817.1 - 0.14 12.5 0.0 10 6.6 0.0 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5060) PQ-loop PF04193.14 VDK69820.1 - 4.2e-23 80.9 10.5 1.2e-14 53.8 0.1 3.3 3 0 0 3 3 3 2 PQ loop repeat Tmemb_18A PF09771.9 VDK69823.1 - 3.1e-47 159.8 0.0 3.6e-47 159.6 0.0 1.0 1 0 0 1 1 1 1 Transmembrane protein 188 DUF3989 PF13150.6 VDK69823.1 - 0.027 14.2 0.1 0.074 12.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) UQ_con PF00179.26 VDK69825.1 - 1.3e-27 96.1 0.1 3.4e-21 75.4 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK69825.1 - 0.00016 21.4 0.1 0.00029 20.5 0.1 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B Band_3_cyto PF07565.13 VDK69826.1 - 3.2e-27 96.0 3.4 3.6e-27 95.9 0.1 2.0 2 0 0 2 2 2 1 Band 3 cytoplasmic domain HCO3_cotransp PF00955.21 VDK69828.1 - 1.6e-192 640.9 16.3 1.5e-97 327.5 4.0 2.1 1 1 1 2 2 2 2 HCO3- transporter family Band_3_cyto PF07565.13 VDK69828.1 - 2.7e-61 207.8 0.0 4.5e-61 207.0 0.0 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain PTR2 PF00854.21 VDK69830.1 - 1.4e-108 363.3 12.0 7e-98 328.0 6.4 2.2 2 0 0 2 2 2 2 POT family H_PPase PF03030.16 VDK69830.1 - 0.067 11.8 1.6 0.13 10.9 1.6 1.4 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase G-patch PF01585.23 VDK69832.1 - 5.2e-14 51.8 2.2 1e-13 50.9 2.2 1.5 1 0 0 1 1 1 1 G-patch domain DND1_DSRM PF14709.7 VDK69832.1 - 6.3e-09 36.0 0.1 1e-08 35.3 0.1 1.4 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 dsrm PF00035.26 VDK69832.1 - 1.5e-08 35.2 0.3 4.3e-08 33.7 0.0 1.9 3 0 0 3 3 3 1 Double-stranded RNA binding motif G-patch_2 PF12656.7 VDK69832.1 - 0.0082 16.2 0.1 0.048 13.8 0.2 1.9 2 0 0 2 2 2 1 G-patch domain dsRBD2 PF17842.1 VDK69832.1 - 0.048 13.9 0.1 0.067 13.4 0.1 1.3 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 NIF PF03031.18 VDK69834.1 - 1.1e-52 177.9 0.2 1.7e-52 177.3 0.2 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SUIM_assoc PF16619.5 VDK69835.1 - 0.0047 17.0 1.3 0.0052 16.8 1.3 1.3 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Med3 PF11593.8 VDK69835.1 - 0.93 8.6 6.3 1.1 8.4 6.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RNase_H PF00075.24 VDK69874.1 - 1.4e-22 80.4 0.1 3.3e-22 79.2 0.0 1.6 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 VDK69874.1 - 8.2e-05 22.4 0.0 0.00013 21.8 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like zf-AN1 PF01428.16 VDK69875.1 - 2.4e-08 34.0 13.3 2.4e-08 34.0 13.3 2.6 2 0 0 2 2 2 1 AN1-like Zinc finger zf-C3HC PF07967.13 VDK69875.1 - 0.027 14.5 2.4 0.044 13.8 2.4 1.4 1 0 0 1 1 1 0 C3HC zinc finger-like Phage_TTP_13 PF16463.5 VDK69875.1 - 0.031 13.8 0.1 0.047 13.2 0.1 1.2 1 0 0 1 1 1 0 Phage tail tube protein family DSHCT PF08148.12 VDK69875.1 - 0.093 12.4 0.1 0.14 11.9 0.1 1.2 1 0 0 1 1 1 0 DSHCT (NUC185) domain ERK-JNK_inhib PF15002.6 VDK69876.1 - 4.4e-58 196.2 7.0 5.3e-58 195.9 7.0 1.1 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor HpaB PF03241.13 VDK69876.1 - 0.015 14.4 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal B12D PF06522.11 VDK69876.1 - 0.13 12.1 3.7 3.1 7.7 0.0 2.8 3 0 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit NCKAP5 PF15246.6 VDK69877.1 - 0.072 12.7 4.1 0.12 11.9 4.1 1.3 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Macoilin PF09726.9 VDK69877.1 - 4 5.9 11.4 5.4 5.4 11.4 1.1 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 VDK69877.1 - 7.7 5.6 8.5 10 5.2 8.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter EGF_CA PF07645.15 VDK69878.1 - 9.5e-71 233.8 315.9 4.2e-08 33.3 4.1 26.0 23 3 3 26 26 25 21 Calcium-binding EGF domain EGF_3 PF12947.7 VDK69878.1 - 3.2e-56 187.2 318.8 1.5e-07 31.4 8.6 26.2 25 1 1 26 26 26 18 EGF domain EGF PF00008.27 VDK69878.1 - 3.1e-48 161.6 327.5 2.2e-06 27.8 2.6 26.4 26 0 0 26 26 25 21 EGF-like domain VWA PF00092.28 VDK69878.1 - 2.6e-41 141.8 0.5 4.3e-41 141.1 0.5 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain hEGF PF12661.7 VDK69878.1 - 8.8e-37 124.5 270.9 3.5e-06 27.4 0.8 28.1 28 0 0 28 28 27 18 Human growth factor-like EGF VWA_2 PF13519.6 VDK69878.1 - 1e-15 58.3 0.0 1.9e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain SEA PF01390.20 VDK69878.1 - 4.3e-07 30.0 0.1 9.3e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 SEA domain cEGF PF12662.7 VDK69878.1 - 4.6e-06 26.5 179.1 0.0049 16.8 0.4 23.9 24 1 0 24 24 23 12 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 VDK69878.1 - 0.00083 19.4 5.3 0.00083 19.4 5.3 24.0 24 1 2 26 26 26 11 MSP1 EGF domain 1 FXa_inhibition PF14670.6 VDK69878.1 - 0.0015 18.8 314.7 0.011 16.0 1.0 26.2 24 2 2 26 26 24 18 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 VDK69878.1 - 0.0084 16.4 1.4 0.0084 16.4 1.4 23.8 24 0 0 24 24 23 10 Pvs28 EGF domain Vpu PF00558.19 VDK69879.1 - 0.14 12.0 0.2 0.14 12.0 0.2 1.6 2 0 0 2 2 2 0 Vpu protein DUF4834 PF16118.5 VDK69879.1 - 0.3 12.1 2.7 1.1 10.3 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Cation_efflux PF01545.21 VDK69881.1 - 1.4e-23 83.7 1.7 4.1e-23 82.2 1.7 1.7 1 1 0 1 1 1 1 Cation efflux family Fringe PF02434.16 VDK69882.1 - 7.1e-13 48.6 0.1 3.1e-12 46.5 0.1 1.9 1 1 0 1 1 1 1 Fringe-like FGGY_N PF00370.21 VDK69882.1 - 1.7e-12 47.5 0.1 9.8e-12 45.0 0.1 2.1 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Galactosyl_T PF01762.21 VDK69882.1 - 0.00026 20.9 0.0 0.017 14.9 0.2 2.5 1 1 1 2 2 2 1 Galactosyltransferase DEDD_Tnp_IS110 PF01548.17 VDK69882.1 - 0.0024 17.8 0.0 0.0041 17.0 0.0 1.3 1 0 0 1 1 1 1 Transposase ROK PF00480.20 VDK69882.1 - 0.011 15.2 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 ROK family BcrAD_BadFG PF01869.20 VDK69882.1 - 0.023 14.2 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family MENTAL PF10457.9 VDK69884.1 - 5.4e-41 140.4 5.8 9.3e-41 139.6 5.8 1.4 1 0 0 1 1 1 1 Cholesterol-capturing domain START PF01852.19 VDK69884.1 - 5.1e-21 75.0 0.0 8.1e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 START domain T6SS_HCP PF05638.12 VDK69884.1 - 0.02 15.3 0.1 0.059 13.8 0.0 1.8 2 0 0 2 2 2 0 Type VI secretion system effector, Hcp DUF4216 PF13952.6 VDK69884.1 - 0.046 14.1 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4216) PID_2 PF14719.6 VDK69885.1 - 0.0016 18.3 0.0 0.032 14.1 0.0 2.2 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) FemAB_like PF04339.12 VDK69886.1 - 0.016 14.3 0.0 0.023 13.8 0.0 1.1 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition DUF2040 PF09745.9 VDK69886.1 - 0.24 11.5 1.7 3.5 7.7 0.4 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 55 (DUF2040) Adaptin_N PF01602.20 VDK69887.1 - 3.7e-162 540.5 17.7 6.6e-162 539.7 17.7 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 VDK69887.1 - 2.7e-65 219.3 15.8 2.1e-62 210.0 3.0 3.8 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 VDK69887.1 - 1.1e-30 105.9 0.7 2.9e-30 104.6 0.7 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 VDK69887.1 - 1.8e-21 76.3 1.4 8.7e-06 26.0 0.0 5.8 2 2 3 6 6 6 4 HEAT repeats Alpha_adaptinC2 PF02883.20 VDK69887.1 - 1.4e-10 41.4 0.1 4.5e-10 39.8 0.1 1.9 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT PF02985.22 VDK69887.1 - 1.7e-10 40.2 8.8 0.019 15.2 0.0 7.1 8 0 0 8 8 7 3 HEAT repeat Cnd3 PF12719.7 VDK69887.1 - 6.9e-07 28.8 8.1 6e-06 25.7 0.3 3.4 1 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain Arm PF00514.23 VDK69887.1 - 3.6e-05 23.6 1.8 0.91 9.7 0.2 4.6 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 VDK69887.1 - 5.6e-05 22.8 3.3 0.022 14.3 0.2 3.9 2 2 1 3 3 3 2 CLASP N terminal HEAT_EZ PF13513.6 VDK69887.1 - 0.00038 20.9 0.4 7.8 7.1 0.1 4.9 5 0 0 5 5 5 1 HEAT-like repeat RTP1_C1 PF10363.9 VDK69887.1 - 0.003 17.7 7.3 4.3 7.6 0.1 5.1 1 1 3 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 VDK69887.1 - 0.011 15.7 2.8 0.015 15.2 0.4 2.6 2 0 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Nmad5 PF18757.1 VDK69887.1 - 0.077 13.2 0.1 0.29 11.3 0.1 2.0 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 Alpha_adaptin_C PF02296.16 VDK69887.1 - 0.097 12.9 2.0 0.16 12.1 0.4 2.2 2 0 0 2 2 2 0 Alpha adaptin AP2, C-terminal domain RasGEF_N_2 PF14663.6 VDK69887.1 - 1 9.8 6.0 6.9 7.1 0.1 4.4 4 1 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain bZIP_1 PF00170.21 VDK69889.1 - 3.1e-17 62.4 15.7 3.1e-17 62.4 15.7 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 VDK69889.1 - 2.3e-08 34.0 11.1 5.9e-08 32.7 11.1 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 VDK69889.1 - 0.016 15.7 8.2 0.016 15.7 8.2 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor Ribosomal_60s PF00428.19 VDK69889.1 - 3.1 8.5 10.0 1.2 9.8 6.2 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein pKID PF02173.17 VDK69891.1 - 4.3e-08 32.5 3.3 7.7e-08 31.7 3.3 1.4 1 0 0 1 1 1 1 pKID domain Glycos_transf_2 PF00535.26 VDK69892.1 - 2.4e-21 76.3 0.1 6.8e-21 74.8 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_7C PF02709.14 VDK69892.1 - 2.8e-05 23.7 0.0 5.5e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase ocr PF08684.10 VDK69892.1 - 0.089 13.3 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 DNA mimic ocr HEXIM PF15313.6 VDK69893.1 - 5e-11 43.0 0.7 9.3e-11 42.1 0.7 1.5 1 0 0 1 1 1 1 Hexamethylene bis-acetamide-inducible protein SNAPc19 PF15497.6 VDK69893.1 - 0.0056 17.1 1.5 0.0056 17.1 1.5 1.5 2 0 0 2 2 2 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 SIKE PF05769.11 VDK69893.1 - 0.0066 16.4 1.1 0.0089 16.0 1.1 1.3 1 0 0 1 1 1 1 SIKE family DUF2856 PF11043.8 VDK69893.1 - 0.016 15.3 0.1 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2856) MutL PF13941.6 VDK69893.1 - 0.074 11.6 0.2 0.13 10.8 0.2 1.3 1 1 0 1 1 1 0 MutL protein NYD-SP28_assoc PF14775.6 VDK69893.1 - 0.085 13.0 1.8 0.31 11.2 1.8 1.9 1 1 1 2 2 2 0 Sperm tail C-terminal domain YabA PF06156.13 VDK69893.1 - 0.16 12.6 1.8 0.25 12.0 1.8 1.5 1 1 0 1 1 1 0 Initiation control protein YabA RPAP1_N PF08621.10 VDK69893.1 - 0.2 11.5 3.4 1.7 8.5 0.2 3.0 4 0 0 4 4 4 0 RPAP1-like, N-terminal HEXIM PF15313.6 VDK69895.1 - 2.1e-18 66.8 0.2 2.1e-18 66.8 0.2 2.4 2 1 0 2 2 2 1 Hexamethylene bis-acetamide-inducible protein Androgen_recep PF02166.16 VDK69895.1 - 0.13 11.1 2.9 0.19 10.5 2.9 1.3 1 0 0 1 1 1 0 Androgen receptor RskA PF10099.9 VDK69896.1 - 0.18 12.1 12.2 0.18 12.1 12.2 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Pneumo_ncap PF03246.13 VDK69943.1 - 0.08 11.7 0.0 0.086 11.6 0.0 1.1 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein Pepsin-I3 PF06394.13 VDK69945.1 - 4.2e-08 33.3 0.1 6.3e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Pepsin inhibitor-3-like repeated domain DUF3662 PF12401.8 VDK69945.1 - 0.13 12.6 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2662) ANAPC4_WD40 PF12894.7 VDK69946.1 - 0.00049 20.3 0.0 0.7 10.2 0.0 3.5 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK69946.1 - 0.0019 19.0 4.8 0.31 12.0 0.1 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat Hyd_WA PF06462.12 VDK69946.1 - 0.014 15.4 6.7 0.25 11.4 0.1 4.0 3 0 0 3 3 3 0 Propeller DUF3021 PF11457.8 VDK69949.1 - 0.0039 17.5 0.1 0.0057 17.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3021) WBP-1 PF11669.8 VDK69949.1 - 0.015 15.9 3.9 0.024 15.2 3.9 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 OPA3 PF07047.12 VDK69949.1 - 0.018 14.8 0.1 0.028 14.2 0.1 1.2 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) Ion_trans PF00520.31 VDK69950.1 - 1.5e-34 119.3 8.6 2.4e-34 118.7 8.6 1.2 1 0 0 1 1 1 1 Ion transport protein PAS_9 PF13426.7 VDK69950.1 - 3.4e-18 65.8 0.0 1.2e-17 64.1 0.0 2.0 1 0 0 1 1 1 1 PAS domain cNMP_binding PF00027.29 VDK69950.1 - 1e-11 44.7 0.0 2.8e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PAS_3 PF08447.12 VDK69950.1 - 9.8e-10 38.6 0.0 2.1e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold Ion_trans_2 PF07885.16 VDK69950.1 - 1.1e-08 34.9 0.4 1.1e-08 34.9 0.4 2.5 4 0 0 4 4 4 1 Ion channel PAS PF00989.25 VDK69950.1 - 4.7e-08 33.0 0.0 1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 VDK69950.1 - 1.3e-06 28.6 0.0 2.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 PAS fold Cupin_2 PF07883.11 VDK69950.1 - 0.0045 16.7 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 Cupin domain PAS_8 PF13188.7 VDK69950.1 - 0.1 12.7 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 PAS domain Rer1 PF03248.13 VDK69951.1 - 0.061 13.1 4.4 0.055 13.2 1.6 2.0 2 0 0 2 2 2 0 Rer1 family Y_phosphatase PF00102.27 VDK69952.1 - 1.8e-50 171.7 1.2 3.8e-50 170.7 1.2 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase YcbB PF08664.10 VDK69952.1 - 0.052 13.6 0.5 0.13 12.3 0.5 1.6 1 0 0 1 1 1 0 YcbB domain Troponin PF00992.20 VDK69954.1 - 9.7e-50 168.3 16.1 9.7e-50 168.3 16.1 2.4 2 1 0 2 2 2 1 Troponin Glyco_hydro_31 PF01055.26 VDK69954.1 - 0.021 14.1 0.9 0.029 13.6 0.9 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 31 GEN1_C PF18380.1 VDK69954.1 - 0.026 15.4 4.3 0.063 14.2 4.3 1.7 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain TTRAP PF14203.6 VDK69954.1 - 0.041 13.8 2.9 0.096 12.7 0.7 2.5 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein SH2 PF00017.24 VDK69954.1 - 0.046 13.8 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 SH2 domain RTC4 PF14474.6 VDK69954.1 - 0.079 13.1 0.7 0.21 11.8 0.7 1.7 1 0 0 1 1 1 0 RTC4-like domain MyTH4 PF00784.17 VDK69955.1 - 6.9e-18 65.1 0.0 2e-17 63.6 0.0 1.9 1 0 0 1 1 1 1 MyTH4 domain PH PF00169.29 VDK69955.1 - 8.7e-14 51.9 0.1 4.7e-06 27.1 0.0 2.5 2 0 0 2 2 2 2 PH domain FERM_M PF00373.18 VDK69955.1 - 0.0014 19.0 0.0 0.0039 17.6 0.0 1.7 1 0 0 1 1 1 1 FERM central domain RBD PF02196.15 VDK69955.1 - 0.061 13.4 0.0 10 6.3 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain AAA_23 PF13476.6 VDK69956.1 - 4.8e-31 108.8 1.3 4.8e-31 108.8 1.3 7.8 4 2 0 4 4 2 2 AAA domain SMC_N PF02463.19 VDK69956.1 - 4.1e-08 32.9 0.0 4.1e-08 32.9 0.0 4.4 3 2 0 3 3 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 VDK69956.1 - 1.7e-05 24.8 3.7 6.1e-05 23.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 VDK69956.1 - 0.00023 20.8 0.0 0.0005 19.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 VDK69956.1 - 0.00037 20.3 32.4 0.00037 20.3 32.4 5.2 1 1 2 3 3 2 1 AAA ATPase domain AAA_27 PF13514.6 VDK69956.1 - 0.0007 19.2 7.8 0.0012 18.5 0.0 4.3 4 0 0 4 4 4 1 AAA domain ABC_tran PF00005.27 VDK69956.1 - 0.013 16.0 0.0 0.013 16.0 0.0 6.7 2 1 0 2 2 1 0 ABC transporter AAA_33 PF13671.6 VDK69956.1 - 0.068 13.3 0.0 0.42 10.8 0.0 2.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK69956.1 - 0.21 11.9 0.0 0.21 11.9 0.0 4.8 4 1 0 4 4 4 0 AAA domain AAA_13 PF13166.6 VDK69956.1 - 0.38 9.3 0.0 0.38 9.3 0.0 5.4 3 2 1 4 4 2 0 AAA domain AAA_18 PF13238.6 VDK69956.1 - 0.52 10.8 0.0 0.52 10.8 0.0 4.9 5 1 1 6 6 6 0 AAA domain SMC_N PF02463.19 VDK69957.1 - 4.3e-07 29.6 0.1 5.7e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 VDK69957.1 - 0.00015 22.0 0.0 0.00032 20.9 0.0 1.6 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 VDK69957.1 - 0.0013 18.6 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system MecA_N PF05223.11 VDK69957.1 - 0.012 15.9 0.9 0.019 15.2 0.4 1.6 1 1 1 2 2 2 0 NTF2-like N-terminal transpeptidase domain AAA_13 PF13166.6 VDK69957.1 - 0.1 11.2 2.7 0.65 8.6 2.7 1.9 1 1 0 1 1 1 0 AAA domain DUF5442 PF17514.2 VDK69957.1 - 0.11 12.7 0.6 1.1 9.5 0.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5442) Ribonucleas_3_3 PF14622.6 VDK69958.1 - 2.7e-42 144.0 0.0 7.6e-22 77.8 0.0 3.5 2 1 1 3 3 3 3 Ribonuclease-III-like Ribonuclease_3 PF00636.26 VDK69958.1 - 4.2e-41 139.8 0.2 5.7e-19 68.7 0.1 3.2 2 0 0 2 2 2 2 Ribonuclease III domain dsrm PF00035.26 VDK69958.1 - 3.3e-09 37.3 0.0 8.5e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif BNIP2 PF12496.8 VDK69958.1 - 5.2 7.5 11.2 9.5 6.7 0.8 2.6 1 1 1 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 PPR_long PF17177.4 VDK69959.1 - 0.035 13.5 0.1 0.12 11.8 0.1 2.0 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP F-box-like PF12937.7 VDK69961.1 - 0.0017 18.2 0.1 0.0048 16.8 0.1 1.7 1 0 0 1 1 1 1 F-box-like DUF475 PF04332.15 VDK69961.1 - 0.011 15.5 0.1 0.016 15.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF475) DAN PF03045.15 VDK69961.1 - 0.28 11.2 1.2 5.9 7.0 0.0 2.5 2 1 0 2 2 2 0 DAN domain DUF5113 PF17140.4 VDK69963.1 - 0.046 13.5 1.1 0.074 12.9 0.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) Aldedh PF00171.22 VDK69965.1 - 2e-80 270.6 0.0 2.4e-80 270.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Cys_knot PF00007.22 VDK69972.1 - 6.8e-08 32.8 9.1 8.8e-08 32.4 9.1 1.1 1 0 0 1 1 1 1 Cystine-knot domain DAN PF03045.15 VDK69972.1 - 7.1e-07 29.2 6.3 9.7e-07 28.8 6.3 1.1 1 0 0 1 1 1 1 DAN domain PH_15 PF17339.2 VDK69975.1 - 3.7e-24 84.7 0.0 7.2e-23 80.5 0.0 2.6 2 1 0 2 2 2 1 PH domain COX16 PF14138.6 VDK69976.1 - 1.9e-09 37.9 0.0 3.1e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 UPF0242 PF06785.11 VDK69976.1 - 0.072 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Pkinase PF00069.25 VDK70013.1 - 1.3e-65 221.4 0.0 1.8e-65 221.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70013.1 - 2.3e-35 122.2 0.0 3.3e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK70013.1 - 2.9e-06 26.8 0.0 4.7e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK70013.1 - 0.00014 21.3 0.2 0.00024 20.5 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 VDK70013.1 - 0.0005 19.1 0.2 0.00098 18.2 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Edc3_linker PF16598.5 VDK70013.1 - 0.026 15.2 3.0 0.051 14.2 0.1 2.4 2 0 0 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 APH PF01636.23 VDK70013.1 - 0.072 13.0 0.1 0.31 10.9 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 VDK70013.1 - 0.22 10.2 0.0 0.22 10.2 0.0 2.2 2 0 0 2 2 2 0 Fungal protein kinase BDV_P10 PF06515.11 VDK70013.1 - 0.26 11.3 2.1 0.5 10.5 0.1 2.2 2 0 0 2 2 2 0 Borna disease virus P10 protein DUF1397 PF07165.11 VDK70014.1 - 6.3e-05 22.5 2.3 0.01 15.3 0.3 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1397) CPG4 PF15481.6 VDK70014.1 - 0.00017 22.1 4.0 0.0073 16.9 1.0 3.1 1 1 2 3 3 3 1 Chondroitin proteoglycan 4 DUF19 PF01579.18 VDK70014.1 - 0.0063 16.3 0.9 0.02 14.7 0.9 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF19) Glyco_transf_92 PF01697.27 VDK70015.1 - 4.5e-38 131.4 0.9 4.6e-37 128.1 0.9 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 92 Ion_trans_2 PF07885.16 VDK70016.1 - 2.3e-18 65.9 0.3 4e-18 65.2 0.3 1.4 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 VDK70016.1 - 0.004 16.4 0.2 0.0062 15.8 0.2 1.2 1 0 0 1 1 1 1 Ion transport protein IRK PF01007.20 VDK70016.1 - 0.015 15.1 0.1 0.026 14.4 0.1 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 VDK70017.1 - 1.1e-20 73.3 3.2 1.5e-20 72.9 3.2 1.1 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 VDK70017.1 - 0.00034 19.9 1.4 0.00048 19.4 1.4 1.3 1 0 0 1 1 1 1 Ion transport protein Pes-10 PF07149.11 VDK70017.1 - 0.062 12.3 1.0 0.069 12.2 1.0 1.1 1 0 0 1 1 1 0 Pes-10 Tmemb_55A PF09788.9 VDK70017.1 - 0.065 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 55A PAS_3 PF08447.12 VDK70019.1 - 6.1e-11 42.5 0.0 2e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold HLH PF00010.26 VDK70019.1 - 3.2e-05 23.8 4.8 7.1e-05 22.7 4.8 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_11 PF14598.6 VDK70019.1 - 0.00012 22.1 0.0 0.00032 20.8 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 VDK70019.1 - 0.0062 16.5 0.0 0.11 12.4 0.0 2.7 3 0 0 3 3 3 1 PAS fold Armet PF10208.9 VDK70019.1 - 0.041 13.8 0.0 4 7.4 0.0 2.5 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding RabGAP-TBC PF00566.18 VDK70027.1 - 3.8e-27 95.3 12.4 3.7e-14 52.9 4.3 3.1 2 1 0 2 2 2 2 Rab-GTPase-TBC domain K-box PF01486.17 VDK70027.1 - 0.051 13.8 0.0 0.16 12.2 0.0 1.8 1 0 0 1 1 1 0 K-box region BioT2 PF15368.6 VDK70027.1 - 0.055 13.4 0.2 9.6 6.1 0.0 2.4 2 0 0 2 2 2 0 Spermatogenesis family BioT2 SM-ATX PF14438.6 VDK70028.1 - 4.3e-18 65.2 0.0 9.7e-18 64.1 0.0 1.7 1 0 0 1 1 1 1 Ataxin 2 SM domain LsmAD PF06741.13 VDK70028.1 - 1.2e-06 29.0 1.6 4e-06 27.3 1.6 2.0 1 0 0 1 1 1 1 LsmAD domain LSM PF01423.22 VDK70028.1 - 0.0042 16.7 0.0 0.0076 15.9 0.0 1.4 1 0 0 1 1 1 1 LSM domain RabGAP-TBC PF00566.18 VDK70029.1 - 1.2e-47 162.4 0.0 2.8e-47 161.2 0.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Herpes_UL49_2 PF04823.12 VDK70032.1 - 0.048 13.8 0.5 0.057 13.5 0.5 1.2 1 0 0 1 1 1 0 Herpesvirus UL49 tegument protein CbiG_C PF01890.16 VDK70032.1 - 0.11 13.1 0.1 0.11 13.1 0.1 1.1 1 0 0 1 1 1 0 Cobalamin synthesis G C-terminus Peptidase_C9 PF01707.16 VDK70032.1 - 0.12 11.9 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Peptidase family C9 CC PF04942.14 VDK70034.1 - 4.4e-10 39.6 124.5 0.00089 19.4 12.1 9.5 9 0 0 9 9 9 8 CC domain EB PF01683.18 VDK70034.1 - 8.3e-06 26.0 11.4 8.3e-06 26.0 11.4 7.8 3 2 1 4 4 4 2 EB module Trehalase PF01204.18 VDK70041.1 - 3.2e-136 455.2 0.3 1.1e-135 453.4 0.3 1.7 1 1 0 1 1 1 1 Trehalase GDE_C PF06202.14 VDK70041.1 - 0.00011 21.3 2.7 0.0016 17.5 2.7 2.0 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Glyco_hydro_63 PF03200.16 VDK70041.1 - 0.0045 15.8 0.0 0.0085 14.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Bac_rhamnosid6H PF17389.2 VDK70041.1 - 0.01 15.1 0.4 0.96 8.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain RRM_1 PF00076.22 VDK70042.1 - 5.5e-12 45.3 0.1 1.2e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK70042.1 - 0.12 12.5 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif BTB PF00651.31 VDK70044.1 - 3.8e-08 33.5 0.0 1.2e-07 31.9 0.0 1.8 1 1 1 2 2 2 1 BTB/POZ domain RecO_C PF02565.15 VDK70044.1 - 0.13 12.0 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Recombination protein O C terminal ABC_tran PF00005.27 VDK70046.1 - 3.1e-40 137.9 6.2 3.8e-20 72.8 0.0 3.5 3 1 1 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 VDK70046.1 - 3.7e-22 78.2 5.0 3.7e-22 78.2 5.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 VDK70046.1 - 1.3e-17 64.6 5.5 0.00049 20.0 0.0 4.4 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 VDK70046.1 - 1.8e-09 37.4 1.7 0.00031 20.2 0.2 4.0 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 VDK70046.1 - 1.5e-05 25.1 0.3 0.33 11.1 0.0 3.3 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_15 PF13175.6 VDK70046.1 - 4.7e-05 23.3 8.5 0.061 13.0 2.2 4.0 3 1 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 VDK70046.1 - 0.00031 20.4 0.6 0.51 10.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 VDK70046.1 - 0.0008 19.8 0.3 0.16 12.3 0.0 2.8 3 0 0 3 3 2 1 AAA ATPase domain Dynamin_N PF00350.23 VDK70046.1 - 0.00087 19.4 0.4 1.1 9.4 0.0 3.5 3 0 0 3 3 3 1 Dynamin family AAA_22 PF13401.6 VDK70046.1 - 0.0011 19.3 0.2 1.9 8.8 0.0 3.3 4 0 0 4 4 2 1 AAA domain RsgA_GTPase PF03193.16 VDK70046.1 - 0.0011 18.9 0.2 1.5 8.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 VDK70046.1 - 0.0055 16.5 0.2 1.4 8.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 VDK70046.1 - 0.009 16.2 2.8 4.1 7.6 0.0 3.5 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 VDK70046.1 - 0.017 14.6 0.0 4.8 6.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 VDK70046.1 - 0.018 15.0 3.4 3.6 7.5 0.0 3.2 4 0 0 4 4 3 0 NACHT domain RNA_helicase PF00910.22 VDK70046.1 - 0.021 15.2 0.0 14 6.1 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 VDK70046.1 - 0.021 14.5 0.0 6.6 6.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.6 VDK70046.1 - 0.024 14.7 0.0 2.6 8.1 0.0 3.5 4 0 0 4 4 3 0 AAA domain Roc PF08477.13 VDK70046.1 - 0.041 14.1 0.1 15 5.9 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 VDK70046.1 - 0.044 13.4 0.4 9.1 5.8 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 VDK70046.1 - 0.057 13.9 0.0 15 6.0 0.0 3.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 VDK70046.1 - 0.067 13.2 0.3 17 5.5 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 VDK70046.1 - 0.075 12.9 0.5 18 5.2 0.0 3.1 3 0 0 3 3 3 0 NTPase AAA_23 PF13476.6 VDK70046.1 - 0.39 11.2 0.0 0.39 11.2 0.0 4.6 4 1 0 4 4 3 0 AAA domain AAA_13 PF13166.6 VDK70046.1 - 0.67 8.5 10.7 2.9 6.4 0.0 3.6 4 0 0 4 4 4 0 AAA domain DUF87 PF01935.17 VDK70046.1 - 0.87 9.6 11.1 11 6.0 0.0 4.4 4 1 0 4 4 4 0 Helicase HerA, central domain RRM_1 PF00076.22 VDK70048.1 - 1.6e-29 101.5 0.0 3.9e-15 55.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOPS PF08075.11 VDK70048.1 - 1.3e-21 76.5 0.1 2.8e-21 75.5 0.1 1.6 1 0 0 1 1 1 1 NOPS (NUC059) domain RRM_7 PF16367.5 VDK70048.1 - 0.01 15.9 0.0 0.054 13.6 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif HIP1_clath_bdg PF16515.5 VDK70048.1 - 0.047 14.3 7.2 0.095 13.3 7.2 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RRM_3 PF08777.11 VDK70048.1 - 0.051 13.6 0.0 0.89 9.6 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif HA2 PF04408.23 VDK70050.1 - 2.3e-19 69.7 0.0 5.1e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 VDK70050.1 - 1.8e-16 60.4 0.0 4.6e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 VDK70050.1 - 1.1e-06 28.9 0.0 2.8e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 VDK70050.1 - 0.00011 22.0 0.0 0.00023 21.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 VDK70050.1 - 0.00021 21.6 0.4 0.0014 18.9 0.2 2.4 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 VDK70050.1 - 0.018 14.9 0.2 0.25 11.2 0.0 2.4 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_30 PF13604.6 VDK70050.1 - 0.067 12.9 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 VDK70050.1 - 0.071 13.6 0.1 0.23 11.9 0.1 1.9 1 1 1 2 2 2 0 ABC transporter AAA_23 PF13476.6 VDK70050.1 - 0.13 12.8 0.0 0.74 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Radical_SAM PF04055.21 VDK70053.1 - 1.1e-30 107.2 0.9 3.2e-30 105.7 0.0 2.3 3 0 0 3 3 3 1 Radical SAM superfamily UPF0004 PF00919.20 VDK70053.1 - 7.5e-26 90.1 1.3 1.6e-25 89.0 1.3 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 VDK70053.1 - 7.1e-07 29.1 0.0 1.2e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 TRAM domain Ribosomal_S21 PF01165.20 VDK70053.1 - 0.24 11.1 1.8 8.8 6.1 0.4 2.5 2 0 0 2 2 2 0 Ribosomal protein S21 Methyltr_RsmB-F PF01189.17 VDK70071.1 - 2e-70 236.5 0.0 3.4e-70 235.8 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 VDK70071.1 - 5.8e-07 29.9 0.0 1.5e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 VDK70071.1 - 0.0013 18.8 0.1 0.0034 17.5 0.1 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase CPSase_L_D3 PF02787.19 VDK70071.1 - 0.15 12.4 0.1 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Collagen PF01391.18 VDK70073.1 - 8.7e-13 47.8 45.7 0.0063 16.2 45.7 3.1 1 1 0 1 1 1 1 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK70073.1 - 2.3e-12 46.8 0.5 3.4e-12 46.2 0.5 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Yip1 PF04893.17 VDK70074.1 - 1.6e-09 37.7 16.5 3e-09 36.9 16.6 1.5 1 1 0 1 1 1 1 Yip1 domain DUF2070 PF09843.9 VDK70074.1 - 0.027 12.8 4.0 0.033 12.5 4.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) LisH_2 PF16045.5 VDK70074.1 - 0.13 11.3 1.5 0.2 10.7 0.1 2.0 2 0 0 2 2 2 0 LisH zf-RanBP PF00641.18 VDK70075.1 - 6e-10 38.3 13.1 6.3e-07 28.6 6.6 2.6 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF2207 PF09972.9 VDK70076.1 - 0.061 12.1 0.1 0.072 11.8 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SLC12 PF03522.15 VDK70078.1 - 9.3e-19 67.8 5.9 4.3e-16 59.0 4.1 2.2 1 1 0 2 2 2 2 Solute carrier family 12 AA_permease PF00324.21 VDK70078.1 - 3.3e-08 32.6 23.2 4.9e-08 32.0 23.2 1.2 1 0 0 1 1 1 1 Amino acid permease DUF3485 PF11984.8 VDK70078.1 - 0.15 11.7 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3485) YPEB PF14620.6 VDK70078.1 - 0.17 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 YpeB sporulation Mannosyl_trans PF05007.13 VDK70080.1 - 1.6e-82 277.3 28.1 2.5e-82 276.6 28.1 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 VDK70080.1 - 1.2e-11 44.3 24.5 1.2e-11 44.3 24.5 1.4 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U TP_methylase PF00590.20 VDK70082.1 - 1.8e-23 83.6 0.0 1.4e-22 80.7 0.0 2.1 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases PMSR PF01625.21 VDK70085.1 - 2.2e-41 141.6 1.9 3.1e-41 141.1 1.9 1.2 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase TPR_6 PF13174.6 VDK70085.1 - 0.04 14.6 0.6 0.11 13.2 0.6 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Retrotrans_gag PF03732.17 VDK70085.1 - 0.097 13.0 1.6 0.3 11.4 1.5 1.9 1 1 0 1 1 1 0 Retrotransposon gag protein SNase PF00565.17 VDK70087.1 - 2.1e-62 208.3 1.1 3.9e-19 69.1 0.0 5.3 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 VDK70087.1 - 8.2e-24 84.0 0.0 1.6e-23 83.0 0.0 1.5 1 0 0 1 1 1 1 Tudor domain DUF3297 PF11730.8 VDK70087.1 - 0.00023 21.0 0.8 0.0031 17.4 0.1 3.1 4 0 0 4 4 4 1 Protein of unknown function (DUF3297) RIBIOP_C PF04950.12 VDK70088.1 - 1.5e-113 379.1 0.0 2.4e-113 378.4 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 VDK70088.1 - 6.2e-16 58.3 0.0 1.8e-15 56.8 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Na_trans_assoc PF06512.13 VDK70088.1 - 4.4 7.5 11.2 8 6.7 11.2 1.3 1 0 0 1 1 1 0 Sodium ion transport-associated Pkinase PF00069.25 VDK70089.1 - 8.7e-65 218.7 0.2 1.4e-64 218.0 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70089.1 - 1.2e-37 129.7 0.3 1.6e-37 129.2 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK70089.1 - 0.00012 21.2 0.5 0.00022 20.3 0.5 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 VDK70089.1 - 0.00034 20.0 0.0 0.0005 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK70089.1 - 0.0025 17.2 0.0 0.0042 16.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WASH-7_mid PF14744.6 VDK70090.1 - 2.2e-123 411.8 4.7 2.2e-123 411.8 4.7 1.9 2 0 0 2 2 2 1 WASH complex subunit 7 WASH-7_N PF14745.6 VDK70090.1 - 1.8e-93 314.0 15.7 2.8e-93 313.4 15.7 1.2 1 0 0 1 1 1 1 WASH complex subunit 7, N-terminal WASH-7_C PF14746.6 VDK70090.1 - 1e-47 162.1 0.3 1e-47 162.1 0.3 2.1 2 0 0 2 2 2 1 WASH complex subunit 7, C-terminal FliS PF02561.14 VDK70090.1 - 0.03 14.6 3.8 2.8 8.2 0.1 3.8 3 0 0 3 3 3 0 Flagellar protein FliS DUF2919 PF11143.8 VDK70090.1 - 0.097 13.0 3.7 2.9 8.2 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2919) ArfGap PF01412.18 VDK70091.1 - 5.9e-32 110.2 1.0 5.9e-32 110.2 1.0 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf RHINO PF15319.6 VDK70091.1 - 0.34 10.9 2.5 0.23 11.5 0.4 1.7 1 1 0 1 1 1 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein ANAPC1 PF12859.7 VDK70093.1 - 0.019 15.5 0.0 0.019 15.5 0.0 3.9 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 VDK70093.1 - 0.34 11.4 12.0 18 6.0 0.2 5.3 4 0 0 4 4 4 0 Proteasome/cyclosome repeat Sulfate_transp PF00916.20 VDK70095.1 - 6.6e-73 245.6 25.2 1.3e-38 132.7 9.4 2.3 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 VDK70095.1 - 3.2e-29 100.9 0.2 6.3e-29 100.0 0.2 1.5 1 0 0 1 1 1 1 STAS domain Pkinase PF00069.25 VDK70128.1 - 3.7e-27 95.3 0.0 4.2e-27 95.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70128.1 - 5.9e-14 52.0 0.0 6.9e-14 51.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK70128.1 - 0.0084 14.9 0.0 0.011 14.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK70128.1 - 0.15 11.4 0.1 0.26 10.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Btz PF09405.10 VDK70129.1 - 8.9e-14 51.9 5.1 5.3e-11 42.9 5.1 2.8 1 1 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding Ribosomal_L37ae PF01780.19 VDK70130.1 - 8.4e-42 141.2 12.9 9.4e-42 141.0 12.9 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family CarbpepA_inh PF02977.15 VDK70130.1 - 0.013 15.3 3.8 0.034 13.9 3.8 1.7 1 1 0 1 1 1 0 Carboxypeptidase A inhibitor zf_UBZ PF18439.1 VDK70130.1 - 0.025 14.1 1.2 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger C1_2 PF03107.16 VDK70130.1 - 0.028 14.8 2.3 0.037 14.3 2.3 1.2 1 0 0 1 1 1 0 C1 domain zf-H2C2_2 PF13465.6 VDK70130.1 - 0.057 13.9 4.9 1.8 9.2 0.4 2.3 2 0 0 2 2 2 0 Zinc-finger double domain A2L_zn_ribbon PF08792.10 VDK70130.1 - 0.059 13.1 4.0 2.8 7.7 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-BED PF02892.15 VDK70130.1 - 0.088 12.9 7.2 2.8 8.0 1.4 2.2 1 1 1 2 2 2 0 BED zinc finger DUF1451 PF07295.11 VDK70130.1 - 0.1 12.6 2.4 0.14 12.2 2.4 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Zn_Tnp_IS1595 PF12760.7 VDK70130.1 - 0.17 11.9 4.3 0.32 11.0 4.3 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C2H2_4 PF13894.6 VDK70131.1 - 3.7e-06 27.3 14.3 0.0039 17.9 1.7 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 VDK70131.1 - 0.0032 17.7 5.0 0.0033 17.7 2.5 2.3 2 1 1 3 3 3 1 C2H2-type zinc ribbon E1_UFD PF09358.10 VDK70131.1 - 0.011 16.5 0.7 0.04 14.6 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin fold domain zf-Di19 PF05605.12 VDK70131.1 - 0.036 14.3 8.4 0.26 11.6 2.7 3.4 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 VDK70131.1 - 0.042 14.3 12.8 0.67 10.5 1.3 3.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK70131.1 - 0.12 12.9 17.1 1.5 9.4 4.3 4.0 4 0 0 4 4 4 0 Zinc-finger double domain FOXP-CC PF16159.5 VDK70131.1 - 0.65 10.7 8.3 1.2 9.8 0.8 4.0 3 1 1 4 4 4 0 FOXP coiled-coil domain Ribosomal_L34e PF01199.18 VDK70131.1 - 1.7 9.0 5.1 0.36 11.2 0.5 2.2 3 0 0 3 3 3 0 Ribosomal protein L34e zf-C2H2_9 PF16293.5 VDK70131.1 - 2 8.3 7.4 1.4 8.8 0.3 3.5 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zf-C2H2_6 PF13912.6 VDK70131.1 - 7.4 6.7 10.8 0.98 9.5 1.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger RhoGAP PF00620.27 VDK70132.1 - 3.1e-35 121.2 0.0 6.4e-35 120.2 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 VDK70132.1 - 3.5e-08 33.2 0.7 7.3e-08 32.2 0.7 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 VDK70132.1 - 0.0083 16.4 0.9 0.021 15.1 0.9 1.7 1 0 0 1 1 1 1 C1 domain DUF724 PF05266.14 VDK70132.1 - 0.089 12.6 1.9 0.17 11.7 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-HIT PF04438.16 VDK70132.1 - 3.2 7.7 6.2 1.2 9.1 2.1 2.3 2 0 0 2 2 2 0 HIT zinc finger zf-RING-like PF08746.11 VDK70132.1 - 8.2 6.8 6.4 3 8.2 2.3 2.4 2 0 0 2 2 2 0 RING-like domain RhoGAP PF00620.27 VDK70133.1 - 2.8e-32 111.6 0.0 4.2e-32 111.1 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain Rab5-bind PF09311.11 VDK70135.1 - 0.0097 15.3 5.1 0.011 15.1 4.5 1.4 1 1 0 1 1 1 1 Rabaptin-like protein BLOC1_2 PF10046.9 VDK70135.1 - 0.014 15.6 1.2 0.038 14.3 1.2 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Atg14 PF10186.9 VDK70135.1 - 0.21 10.6 7.7 0.34 10.0 7.7 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TB2_DP1_HVA22 PF03134.19 VDK70137.1 - 4.1e-13 49.1 3.0 4.1e-13 49.1 3.0 2.2 2 1 0 2 2 2 1 TB2/DP1, HVA22 family DUF3827 PF12877.7 VDK70137.1 - 0.032 12.6 1.5 0.042 12.2 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DUF2116 PF09889.9 VDK70137.1 - 0.13 12.3 2.2 1.3 9.1 0.9 2.7 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PCMT PF01135.19 VDK70139.1 - 4.9e-79 265.0 0.1 6.4e-79 264.6 0.1 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 VDK70139.1 - 1.3e-05 25.1 0.1 3e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 VDK70139.1 - 5.5e-05 23.2 1.5 7.7e-05 22.7 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 VDK70139.1 - 6.9e-05 22.4 0.2 0.00017 21.1 0.1 1.6 1 1 1 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 VDK70139.1 - 8.6e-05 23.2 0.0 0.0002 22.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 VDK70139.1 - 0.0002 21.3 0.1 0.00036 20.5 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 VDK70139.1 - 0.00032 20.1 0.0 0.00053 19.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 VDK70139.1 - 0.002 17.7 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain GCD14 PF08704.10 VDK70139.1 - 0.0024 17.6 0.2 0.0052 16.5 0.0 1.6 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.12 VDK70139.1 - 0.0029 18.2 0.0 0.0071 17.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK70139.1 - 0.0061 16.4 0.0 0.015 15.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Toxin_27 PF08099.11 VDK70139.1 - 0.051 13.7 0.2 0.1 12.7 0.2 1.4 1 0 0 1 1 1 0 Scorpion calcine family Fibrillarin PF01269.17 VDK70139.1 - 0.099 11.7 0.1 0.19 10.8 0.1 1.4 1 0 0 1 1 1 0 Fibrillarin FtsJ PF01728.19 VDK70139.1 - 0.13 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase DEAD PF00270.29 VDK70140.1 - 2.5e-45 154.4 0.0 5.5e-45 153.3 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK70140.1 - 2.3e-31 108.4 0.1 1.8e-29 102.3 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK70140.1 - 9.3e-08 32.3 0.0 1.6e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 VDK70140.1 - 0.083 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pro_3_hydrox_C PF05373.11 VDK70140.1 - 0.15 12.2 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal ERCC3_RAD25_C PF16203.5 VDK70140.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase E3_UFM1_ligase PF09743.9 VDK70142.1 - 5.3e-68 229.6 3.9 7.1e-68 229.2 0.3 2.9 3 0 0 3 3 3 1 E3 UFM1-protein ligase 1 COG2 PF06148.11 VDK70142.1 - 1.8e-28 99.3 2.2 1.8e-28 99.3 2.2 2.9 4 0 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 VDK70142.1 - 1e-23 84.1 4.7 1.4e-23 83.6 0.2 3.6 4 1 0 4 4 4 1 Domain of unknown function (DUF3510) Vps51 PF08700.11 VDK70142.1 - 0.00017 21.6 0.9 0.00017 21.6 0.9 3.0 2 0 0 2 2 2 1 Vps51/Vps67 DUF2451 PF10474.9 VDK70142.1 - 0.00099 19.0 0.2 0.038 13.8 0.1 3.4 3 0 0 3 3 3 1 Protein of unknown function C-terminus (DUF2451) Med6 PF04934.14 VDK70147.1 - 1.4e-35 122.0 0.9 6.3e-35 119.9 0.5 1.9 2 0 0 2 2 2 1 MED6 mediator sub complex component UMP1 PF05348.11 VDK70148.1 - 1.8e-05 25.0 0.0 2.6e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Proteasome maturation factor UMP1 DUF5037 PF16440.5 VDK70148.1 - 0.18 11.3 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5037) Pkinase PF00069.25 VDK70150.1 - 1.1e-25 90.5 0.0 1.5e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70150.1 - 7.1e-14 51.7 0.0 1e-13 51.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK70150.1 - 1.3e-07 30.8 0.0 2.4e-07 29.9 0.0 1.3 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK70150.1 - 0.0038 17.2 0.0 0.011 15.7 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 VDK70150.1 - 0.0045 16.4 0.0 0.011 15.1 0.0 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 VDK70150.1 - 0.057 12.3 0.1 0.087 11.8 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain LNS2 PF08235.13 VDK70151.1 - 1.4e-90 302.7 0.0 2.6e-90 301.9 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 VDK70151.1 - 4.1e-39 132.6 0.0 7.7e-39 131.8 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region DUF2090 PF09863.9 VDK70151.1 - 0.079 12.0 0.3 0.12 11.3 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2090) RasGEF PF00617.19 VDK70156.1 - 4.2e-43 147.6 0.0 1e-42 146.4 0.0 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 VDK70156.1 - 2.6e-12 46.9 0.0 2.1e-10 40.8 0.0 2.8 1 1 1 2 2 2 1 RasGEF N-terminal motif RhoGEF PF00621.20 VDK70156.1 - 5.2e-09 36.6 0.4 4.4e-08 33.6 0.1 2.7 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 VDK70156.1 - 1e-05 26.0 0.2 2.8e-05 24.5 0.2 1.8 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 VDK70156.1 - 0.0077 16.2 0.1 0.022 14.8 0.1 1.7 1 0 0 1 1 1 1 PH domain MKT1_N PF12247.8 VDK70156.1 - 0.051 13.9 0.1 1 9.8 0.0 2.9 2 1 1 3 3 3 0 Temperature dependent protein affecting M2 dsRNA replication RecT PF03837.14 VDK70158.1 - 0.19 11.2 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 RecT family DAN PF03045.15 VDK70159.1 - 6.5e-27 93.8 6.4 8.8e-27 93.4 6.4 1.2 1 0 0 1 1 1 1 DAN domain Cys_knot PF00007.22 VDK70159.1 - 0.0095 16.2 4.0 0.015 15.6 4.0 1.3 1 0 0 1 1 1 1 Cystine-knot domain Alg6_Alg8 PF03155.15 VDK70200.1 - 7.7e-74 249.4 41.1 1.1e-73 248.9 41.1 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Alg6_Alg8 PF03155.15 VDK70201.1 - 1.3e-29 103.6 1.6 1.5e-29 103.3 1.6 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Nepo_coat_C PF03688.14 VDK70201.1 - 0.015 15.2 0.0 0.019 14.8 0.0 1.1 1 0 0 1 1 1 0 Nepovirus coat protein, C-terminal domain Esterase PF00756.20 VDK70201.1 - 0.063 12.9 0.1 0.068 12.8 0.1 1.1 1 0 0 1 1 1 0 Putative esterase UBA PF00627.31 VDK70203.1 - 5.1e-25 87.0 1.0 4.9e-13 48.7 0.1 2.6 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 VDK70203.1 - 1e-23 82.8 12.2 1.9e-23 82.0 12.2 1.4 1 0 0 1 1 1 1 XPC-binding domain ubiquitin PF00240.23 VDK70203.1 - 2e-17 62.7 0.1 3.2e-17 62.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA_3 PF09288.10 VDK70203.1 - 4e-05 23.3 0.0 0.36 10.7 0.0 2.5 2 0 0 2 2 2 2 Fungal ubiquitin-associated domain DUF2407 PF10302.9 VDK70203.1 - 0.00061 20.3 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 VDK70203.1 - 0.0025 17.9 0.0 0.0046 17.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 VDK70203.1 - 0.0056 16.5 0.1 0.0096 15.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF1421 PF07223.11 VDK70203.1 - 0.033 14.0 0.0 1.5 8.7 0.0 2.6 2 0 0 2 2 2 0 UBA-like domain (DUF1421) Ubiquitin_5 PF18037.1 VDK70203.1 - 0.043 14.2 0.1 0.077 13.4 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain DUF3135 PF11333.8 VDK70203.1 - 0.089 13.1 0.4 0.34 11.2 0.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3135) Ubiquitin_2 PF14560.6 VDK70203.1 - 0.091 13.2 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain DnaB_2 PF07261.11 VDK70203.1 - 0.093 12.5 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 0 Replication initiation and membrane attachment Sel1 PF08238.12 VDK70204.1 - 1.4e-11 44.6 0.0 0.015 15.9 0.0 5.3 5 0 0 5 5 5 3 Sel1 repeat TPR_8 PF13181.6 VDK70204.1 - 0.33 11.3 5.0 8.1 6.9 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Porin_3 PF01459.22 VDK70205.1 - 8.1e-60 202.6 0.1 9.5e-60 202.3 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin DUF1565 PF07602.11 VDK70205.1 - 0.037 13.4 0.0 0.05 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) SPRY PF00622.28 VDK70207.1 - 1.9e-14 53.8 0.0 3.1e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 SPRY domain SOCS_box PF07525.16 VDK70207.1 - 3.7e-09 36.8 4.5 7.2e-09 35.9 4.5 1.5 1 0 0 1 1 1 1 SOCS box Peptidase_M14 PF00246.24 VDK70208.1 - 5.8e-79 265.9 0.1 7.4e-79 265.5 0.1 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 VDK70208.1 - 1.3e-07 31.9 0.0 2.5e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide Lactamase_B PF00753.27 VDK70216.1 - 5.5e-08 33.1 0.2 1.9e-05 24.7 0.1 2.4 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lustrin_cystein PF14625.6 VDK70216.1 - 2.6e-06 27.7 3.1 5.1e-06 26.8 3.1 1.5 1 0 0 1 1 1 1 Lustrin, cysteine-rich repeated domain CPG4 PF15481.6 VDK70218.1 - 7.9e-10 39.2 11.0 5.8e-08 33.3 4.0 3.0 2 1 1 3 3 3 2 Chondroitin proteoglycan 4 COG6 PF06419.11 VDK70218.1 - 0.012 13.9 0.2 0.022 13.0 0.0 1.4 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 Acyl_transf_1 PF00698.21 VDK70219.1 - 4.7e-21 75.6 0.2 3.5e-20 72.8 0.2 1.9 1 1 0 1 1 1 1 Acyl transferase domain RNA_pol_L PF01193.24 VDK70219.1 - 0.039 13.4 0.0 0.76 9.3 0.0 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Catalase-rel PF06628.12 VDK70219.1 - 0.11 12.7 0.2 4.8 7.5 0.0 2.8 2 1 1 3 3 3 0 Catalase-related immune-responsive ADP_PFK_GK PF04587.15 VDK70221.1 - 5.6e-117 390.9 0.0 7.6e-117 390.4 0.0 1.2 1 0 0 1 1 1 1 ADP-specific Phosphofructokinase/Glucokinase conserved region HORMA PF02301.18 VDK70221.1 - 7.2e-20 71.5 0.1 1.9e-19 70.1 0.1 1.7 1 0 0 1 1 1 1 HORMA domain DASH_Dam1 PF08653.10 VDK70221.1 - 0.013 15.3 0.8 0.059 13.2 0.1 2.5 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF4080 PF13311.6 VDK70221.1 - 0.082 13.1 0.1 0.18 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4080) RNA_pol_Rpb1_5 PF04998.17 VDK70223.1 - 3.1e-88 295.7 0.0 6.6e-88 294.6 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 VDK70223.1 - 5.5e-59 199.1 0.3 1.6e-58 197.6 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 VDK70223.1 - 1.4e-34 119.3 0.0 3.1e-34 118.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 VDK70223.1 - 1.8e-22 80.1 1.7 3.5e-21 75.9 0.0 3.0 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 VDK70223.1 - 1.7e-18 66.5 0.0 8.9e-18 64.2 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 Cytochrome_C7 PF14522.6 VDK70223.1 - 0.76 9.8 4.9 1.4 9.0 1.2 2.9 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c eIF_4EBP PF05456.11 VDK70224.1 - 0.00088 19.2 0.3 0.0062 16.5 0.0 2.1 1 1 0 2 2 2 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Aa_trans PF01490.18 VDK70225.1 - 1.6e-57 195.1 30.3 1.6e-57 195.1 30.3 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 VDK70225.1 - 9.4e-15 54.5 20.1 9.4e-15 54.5 20.1 2.0 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family Thiolase_N PF00108.23 VDK70237.1 - 1.1e-77 260.9 1.3 1.5e-77 260.5 0.9 1.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 VDK70237.1 - 4.3e-46 155.6 0.0 9.8e-46 154.4 0.0 1.6 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 VDK70237.1 - 3.2e-05 23.6 0.5 3.2e-05 23.6 0.5 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain TPR_2 PF07719.17 VDK70239.1 - 4e-15 54.6 16.3 0.015 15.3 0.1 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 VDK70239.1 - 4.5e-12 45.3 19.4 0.0018 18.0 0.1 7.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 VDK70239.1 - 3e-11 42.6 11.4 0.04 14.1 0.1 7.4 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 VDK70239.1 - 7.7e-10 38.9 11.9 0.0001 22.5 0.0 6.9 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK70239.1 - 8.8e-10 37.9 0.1 0.13 12.4 0.0 6.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK70239.1 - 3.3e-07 30.7 6.5 0.88 10.1 0.0 6.8 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 VDK70239.1 - 8.5e-06 25.5 1.3 0.046 13.6 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK70239.1 - 3.2e-05 24.4 10.5 5.4 8.1 0.0 7.6 6 2 2 8 8 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK70239.1 - 0.0011 18.7 1.2 1.1 9.0 0.0 4.0 4 0 0 4 4 3 2 TPR repeat TPR_3 PF07720.12 VDK70239.1 - 0.0051 16.8 5.0 18 5.4 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK70239.1 - 0.012 16.0 3.7 5.1 7.7 0.0 5.4 6 1 1 7 7 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK70239.1 - 0.024 14.8 22.5 0.33 11.2 0.3 7.1 4 2 4 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 VDK70239.1 - 0.048 13.7 0.9 16 5.7 0.0 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat UL141 PF16758.5 VDK70239.1 - 0.053 13.3 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Herpes-like virus membrane glycoprotein UL141 Nup96 PF12110.8 VDK70240.1 - 3.9e-43 147.7 0.2 6.8e-43 146.8 0.2 1.3 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 VDK70240.1 - 8.8e-43 146.0 0.0 1.9e-42 144.9 0.0 1.6 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 VDK70240.1 - 3.1e-13 50.4 151.6 0.26 12.2 20.9 7.4 3 2 2 5 5 5 2 Nucleoporin FG repeat region RTX_C PF08339.10 VDK70240.1 - 0.2 11.7 3.6 1 9.4 0.2 2.8 2 0 0 2 2 2 0 RTX C-terminal domain S_locus_glycop PF00954.20 VDK70246.1 - 0.058 13.9 0.1 0.069 13.7 0.1 1.2 1 0 0 1 1 1 0 S-locus glycoprotein domain POTRA_1 PF08478.10 VDK70246.1 - 0.073 13.4 0.0 0.093 13.0 0.0 1.1 1 0 0 1 1 1 0 POTRA domain, FtsQ-type EF-hand_1 PF00036.32 VDK70249.1 - 3.2e-14 51.3 11.6 1.9e-07 30.2 1.8 4.4 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 VDK70249.1 - 9.4e-14 51.6 9.5 1e-06 29.0 1.5 2.5 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_6 PF13405.6 VDK70249.1 - 5.7e-13 47.7 11.2 1.4e-07 30.9 1.0 3.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 VDK70249.1 - 1.9e-09 36.6 6.5 4.5e-05 22.8 2.4 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 VDK70249.1 - 3.7e-05 23.5 8.3 0.19 11.6 0.2 4.1 2 2 2 4 4 4 4 EF-hand domain pair UPF0154 PF03672.13 VDK70249.1 - 0.015 15.3 0.0 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 VDK70249.1 - 0.021 15.7 0.4 0.098 13.5 0.1 1.9 1 1 1 2 2 2 0 EF-hand domain Syntaxin PF00804.25 VDK70249.1 - 0.061 13.0 0.2 1.3 8.6 0.1 2.1 2 0 0 2 2 2 0 Syntaxin EF-hand_9 PF14658.6 VDK70249.1 - 0.066 13.6 0.0 11 6.4 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 VDK70249.1 - 0.089 13.1 0.1 0.9 9.9 0.0 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region CUE PF02845.16 VDK70249.1 - 0.22 11.2 1.3 0.85 9.4 0.1 2.2 2 0 0 2 2 2 0 CUE domain Gp-FAR-1 PF05823.12 VDK70252.1 - 1.1e-13 51.8 0.1 1.8e-13 51.1 0.1 1.4 1 0 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Gp-FAR-1 PF05823.12 VDK70255.1 - 3.3e-33 115.2 1.9 4.2e-33 114.8 1.9 1.1 1 0 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Ins_allergen_rp PF06757.13 VDK70255.1 - 0.04 13.9 0.6 0.099 12.6 0.5 1.7 2 1 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification SHMT PF00464.19 VDK70256.1 - 1.9e-192 639.3 0.0 2.2e-192 639.0 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 VDK70256.1 - 0.017 14.4 0.0 0.04 13.2 0.0 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 VDK70256.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family CBM_14 PF01607.24 VDK70257.1 - 6.8e-10 39.0 15.7 1e-05 25.6 5.2 2.5 2 0 0 2 2 2 2 Chitin binding Peritrophin-A domain Baculo_VP91_N PF08475.10 VDK70257.1 - 0.039 13.6 5.8 0.62 9.7 0.4 2.6 1 1 1 3 3 3 0 Viral capsid protein 91 N-terminal HTH_Tnp_Tc5 PF03221.16 VDK70260.1 - 2.7e-13 49.7 0.5 5.3e-13 48.8 0.5 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain RNase_PH_C PF03725.15 VDK70260.1 - 0.047 13.7 0.1 0.15 12.1 0.1 1.9 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 ANAPC4_WD40 PF12894.7 VDK70261.1 - 3.5e-11 43.2 0.5 0.014 15.6 0.0 5.2 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK70261.1 - 1e-10 42.0 8.4 0.095 13.6 0.0 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF2A PF08662.11 VDK70261.1 - 0.00065 19.6 0.8 0.027 14.4 0.1 2.8 2 2 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A DFP PF04127.15 VDK70263.1 - 2.3e-09 37.3 0.0 7.1e-06 26.0 0.0 3.1 2 1 1 3 3 3 2 DNA / pantothenate metabolism flavoprotein CHASE7 PF17151.4 VDK70263.1 - 0.075 12.6 0.0 0.16 11.5 0.0 1.5 2 0 0 2 2 2 0 Periplasmic sensor domain Lung_7-TM_R PF06814.13 VDK70263.1 - 0.081 12.2 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 Lung seven transmembrane receptor Pkinase_fungal PF17667.1 VDK70271.1 - 0.088 11.6 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pkinase PF00069.25 VDK70272.1 - 3.3e-27 95.5 0.0 4.2e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70272.1 - 2.1e-15 56.7 0.0 2.8e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK70272.1 - 4.7e-11 42.1 0.0 5.4e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase ABC1 PF03109.16 VDK70272.1 - 0.048 13.8 0.0 0.28 11.4 0.0 2.2 3 0 0 3 3 3 0 ABC1 family APH PF01636.23 VDK70272.1 - 0.11 12.4 0.0 0.81 9.6 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 VDK70273.1 - 4.5e-27 95.1 0.0 5.5e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70273.1 - 3.3e-15 56.1 0.0 4.1e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK70273.1 - 3.5e-08 32.7 0.1 4.1e-08 32.4 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK70273.1 - 0.0034 17.3 0.1 2.3 8.1 0.1 2.2 1 1 0 2 2 2 2 Phosphotransferase enzyme family ABC1 PF03109.16 VDK70273.1 - 0.028 14.6 0.0 0.078 13.1 0.0 1.7 2 0 0 2 2 2 0 ABC1 family Pox_ser-thr_kin PF05445.11 VDK70273.1 - 0.048 12.6 0.1 0.086 11.8 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EF-hand_7 PF13499.6 VDK70276.1 - 6.4e-19 68.2 1.0 3.2e-10 40.3 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK70276.1 - 2.5e-17 61.0 0.2 6.8e-05 22.1 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 VDK70276.1 - 3.6e-15 54.5 0.2 2.3e-05 24.0 0.1 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 VDK70276.1 - 9.9e-13 47.7 3.3 4.1e-07 29.7 0.1 3.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 VDK70276.1 - 1.3e-10 41.4 0.1 0.00047 20.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 VDK70276.1 - 0.013 15.0 1.5 0.042 13.4 0.0 2.7 3 0 0 3 3 3 0 EF hand Sigma70_r1_1 PF03979.14 VDK70276.1 - 0.027 14.5 2.5 0.12 12.4 0.4 2.4 2 1 0 2 2 2 0 Sigma-70 factor, region 1.1 Staphylokinase PF02821.16 VDK70276.1 - 0.028 14.9 0.4 0.27 11.7 0.3 2.2 1 1 1 2 2 2 0 Staphylokinase/Streptokinase family EF-hand_14 PF17959.1 VDK70276.1 - 0.039 14.3 0.2 1.8 9.0 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain HHA PF05321.11 VDK70276.1 - 0.082 13.2 0.2 0.46 10.8 0.0 2.1 2 0 0 2 2 2 0 Haemolysin expression modulating protein GPHH PF16905.5 VDK70276.1 - 0.088 12.6 0.0 0.37 10.6 0.0 2.0 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Caleosin PF05042.13 VDK70276.1 - 0.1 12.5 0.1 16 5.4 0.0 2.6 1 1 2 3 3 3 0 Caleosin related protein DUF592 PF04574.13 VDK70276.1 - 0.1 12.4 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF592) Tn7_Tnp_TnsA_C PF08721.11 VDK70276.1 - 0.22 12.2 1.0 0.78 10.4 0.1 2.2 2 1 1 3 3 2 0 TnsA endonuclease C terminal Methyltransf_16 PF10294.9 VDK70277.1 - 2.6e-20 72.9 0.2 7.4e-20 71.4 0.0 1.8 1 1 1 2 2 2 1 Lysine methyltransferase Cons_hypoth95 PF03602.15 VDK70277.1 - 4.6e-05 23.1 0.0 0.024 14.3 0.0 2.2 2 0 0 2 2 2 2 Conserved hypothetical protein 95 MTS PF05175.14 VDK70277.1 - 0.00013 21.6 0.0 0.00024 20.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 VDK70277.1 - 0.0031 18.2 0.1 0.0096 16.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK70277.1 - 0.032 14.0 0.1 0.069 12.9 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 VDK70277.1 - 0.045 13.1 0.1 0.067 12.6 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 VDK70277.1 - 0.083 12.8 0.0 0.58 10.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain FAM86 PF14904.6 VDK70277.1 - 0.13 12.3 0.2 0.35 11.0 0.2 1.8 1 1 0 1 1 1 0 Family of unknown function MMR_HSR1_Xtn PF16897.5 VDK70280.1 - 3.5e-41 139.5 0.6 6.9e-41 138.6 0.6 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 VDK70280.1 - 4.4e-22 77.9 0.0 8.3e-22 77.0 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 VDK70280.1 - 1.2e-17 64.1 0.0 7.6e-17 61.4 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK70280.1 - 3.3e-10 39.7 0.1 8.6e-09 35.1 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 VDK70280.1 - 0.021 14.4 0.1 3.2 7.2 0.0 3.2 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 VDK70280.1 - 0.022 14.8 0.0 0.65 10.0 0.0 2.2 1 1 1 2 2 2 0 Dynamin family PX PF00787.24 VDK70281.1 - 1e-14 54.4 0.0 2.2e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 PX domain Pkinase PF00069.25 VDK70281.1 - 0.028 13.8 0.0 0.17 11.2 0.0 2.1 1 1 0 1 1 1 0 Protein kinase domain DASH_Dam1 PF08653.10 VDK70282.1 - 0.014 15.1 0.6 0.088 12.6 0.0 2.6 2 0 0 2 2 2 0 DASH complex subunit Dam1 LAGLIDADG_3 PF14528.6 VDK70282.1 - 0.088 13.1 0.2 1.3 9.4 0.0 2.9 2 0 0 2 2 2 0 LAGLIDADG-like domain SF3b10 PF07189.11 VDK70284.1 - 3e-35 120.2 0.0 6.1e-35 119.2 0.0 1.6 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) CX PF01705.19 VDK70285.1 - 9.7e-17 61.3 8.1 1.4e-16 60.8 8.1 1.2 1 0 0 1 1 1 1 CX module Conotoxin_I2 PF17557.2 VDK70285.1 - 0.063 13.4 7.3 0.063 13.4 7.3 1.7 2 0 0 2 2 2 0 I2-superfamily conotoxins CX PF01705.19 VDK70286.1 - 1.6e-08 35.0 6.5 3.8e-07 30.6 3.4 2.3 2 0 0 2 2 2 2 CX module Guanylate_kin PF00625.21 VDK70328.1 - 6.4e-40 136.8 0.0 9.9e-40 136.2 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase SH3_2 PF07653.17 VDK70328.1 - 0.00034 20.2 0.0 0.00093 18.8 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain PDZ_6 PF17820.1 VDK70328.1 - 0.0071 16.2 0.2 0.13 12.2 0.0 3.0 2 1 1 3 3 3 1 PDZ domain SH3_1 PF00018.28 VDK70328.1 - 0.017 14.7 0.0 0.038 13.6 0.0 1.7 1 0 0 1 1 1 0 SH3 domain PDZ PF00595.24 VDK70328.1 - 0.032 14.6 0.0 0.1 13.0 0.0 1.8 1 0 0 1 1 1 0 PDZ domain AAA_33 PF13671.6 VDK70328.1 - 0.072 13.2 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain FAM25 PF15825.5 VDK70328.1 - 0.16 12.3 1.9 0.3 11.5 1.9 1.4 1 0 0 1 1 1 0 FAM25 family FYVE PF01363.21 VDK70329.1 - 5.3e-20 71.3 10.5 1.2e-19 70.2 10.5 1.5 1 0 0 1 1 1 1 FYVE zinc finger DUF2096 PF09869.9 VDK70329.1 - 0.082 13.0 0.3 0.37 10.9 0.0 2.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) GH101_N PF17995.1 VDK70329.1 - 0.15 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase N-terminal IBR PF01485.21 VDK70329.1 - 0.22 11.7 7.6 0.57 10.4 7.6 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain FYVE_2 PF02318.16 VDK70329.1 - 0.35 11.1 9.3 0.52 10.5 7.6 2.0 2 0 0 2 2 2 0 FYVE-type zinc finger zf_C2HC_14 PF18574.1 VDK70329.1 - 1.8 8.4 6.4 4.3 7.2 6.4 1.6 1 0 0 1 1 1 0 C2HC Zing finger domain Zn-ribbon_8 PF09723.10 VDK70329.1 - 3.8 7.7 6.0 23 5.2 6.1 2.3 1 1 0 1 1 1 0 Zinc ribbon domain GTP_EFTU PF00009.27 VDK70334.1 - 2.9e-51 173.8 0.0 4.6e-51 173.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 VDK70334.1 - 2.7e-28 98.3 0.6 4.6e-28 97.5 0.6 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 VDK70334.1 - 3.5e-10 39.8 0.0 7.8e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 VDK70334.1 - 3.8e-06 26.9 0.0 1.1e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 VDK70334.1 - 6.2e-05 23.0 0.0 0.00013 22.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RF3_C PF16658.5 VDK70334.1 - 0.00024 20.9 0.0 0.00061 19.6 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 VDK70334.1 - 0.00077 19.8 0.0 0.0016 18.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 VDK70334.1 - 0.0063 16.1 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Ras family SBDS_C PF09377.10 VDK70334.1 - 0.027 14.5 0.1 0.06 13.4 0.1 1.5 1 0 0 1 1 1 0 SBDS protein C-terminal domain AIG1 PF04548.16 VDK70334.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 AIG1 family MMR_HSR1_Xtn PF16897.5 VDK70334.1 - 0.13 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Tetraspanin PF00335.20 VDK70335.1 - 1.2e-34 120.0 12.4 1.5e-34 119.8 12.4 1.1 1 0 0 1 1 1 1 Tetraspanin family zf-C2H2_4 PF13894.6 VDK70336.1 - 1.1e-16 60.1 100.0 0.0092 16.7 1.4 15.8 15 1 0 15 15 15 8 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK70336.1 - 5.5e-08 32.8 101.8 0.017 15.6 1.2 14.7 15 0 0 15 15 15 9 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK70336.1 - 2.7e-07 30.7 53.3 0.042 14.3 0.2 12.1 12 0 0 12 12 12 4 Zinc-finger double domain zf-C2H2_6 PF13912.6 VDK70336.1 - 5.2e-05 23.1 8.1 0.0014 18.5 0.5 9.6 12 0 0 12 12 12 4 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 VDK70336.1 - 0.00041 21.0 68.3 0.019 15.6 6.8 8.3 3 1 6 9 9 9 5 Zinc finger C2H2-type, 3 repeats Ribosomal_L34e PF01199.18 VDK70336.1 - 0.012 15.9 7.3 1.4 9.3 0.3 4.9 4 0 0 4 4 4 0 Ribosomal protein L34e zf-Di19 PF05605.12 VDK70336.1 - 0.015 15.6 84.4 0.2 12.0 0.9 10.4 6 4 4 10 10 10 0 Drought induced 19 protein (Di19), zinc-binding TMEM51 PF15345.6 VDK70336.1 - 0.18 11.6 3.7 0.33 10.8 3.7 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 zf-C2H2_jaz PF12171.8 VDK70336.1 - 0.39 11.1 72.2 0.077 13.3 1.0 12.9 15 0 0 15 15 13 0 Zinc-finger double-stranded RNA-binding HPIP PF15226.6 VDK70336.1 - 1.9 8.9 4.8 24 5.4 0.1 3.3 2 1 1 3 3 3 0 HCF-1 beta-propeller-interacting protein family Presenilin PF01080.17 VDK70336.1 - 5.7 5.6 7.4 8.4 5.0 7.4 1.2 1 0 0 1 1 1 0 Presenilin FYDLN_acid PF09538.10 VDK70336.1 - 6 7.6 13.0 0.16 12.7 2.1 3.7 4 0 0 4 4 3 0 Protein of unknown function (FYDLN_acid) Spt20 PF12090.8 VDK70336.1 - 8.9 5.9 22.8 23 4.5 22.8 1.6 1 0 0 1 1 1 0 Spt20 family DUF4728 PF15860.5 VDK70337.1 - 1.4e-05 25.7 4.0 1.4e-05 25.7 4.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4728) DUF3796 PF12676.7 VDK70337.1 - 0.04 14.3 3.8 0.09 13.2 3.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3796) PIG-P PF08510.12 VDK70337.1 - 0.12 12.3 1.9 0.34 10.8 1.9 1.7 1 0 0 1 1 1 0 PIG-P Mtp PF03821.16 VDK70337.1 - 0.13 11.8 7.5 2.2 7.8 0.0 2.5 1 1 1 2 2 2 0 Golgi 4-transmembrane spanning transporter DUF2070 PF09843.9 VDK70337.1 - 0.61 8.3 7.9 0.77 8.0 7.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Yip1 PF04893.17 VDK70337.1 - 1.5 8.5 12.1 0.68 9.6 1.7 2.3 1 1 1 2 2 2 0 Yip1 domain PTS_EIIC PF02378.18 VDK70337.1 - 4.3 6.3 11.8 3.3 6.6 3.6 2.1 2 0 0 2 2 2 0 Phosphotransferase system, EIIC EMP24_GP25L PF01105.24 VDK70339.1 - 5.7e-42 143.7 0.2 6.8e-42 143.5 0.2 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4115 PF13464.6 VDK70339.1 - 0.089 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) DUF4198 PF10670.9 VDK70339.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) Glyco_transf_90 PF05686.12 VDK70341.1 - 1.3e-59 202.1 4.2 1.8e-59 201.7 4.2 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Nop PF01798.18 VDK70344.1 - 5.5e-83 277.9 0.1 1.1e-82 276.9 0.1 1.5 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 VDK70344.1 - 4e-24 84.8 0.3 1.2e-23 83.3 0.3 1.9 1 0 0 1 1 1 1 NOP5NT (NUC127) domain tRNA-synt_His PF13393.6 VDK70344.1 - 0.071 12.4 0.8 0.19 11.0 0.4 1.9 2 1 0 2 2 2 0 Histidyl-tRNA synthetase Pribosyltran PF00156.27 VDK70346.1 - 1.9e-15 56.7 0.0 3.2e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 VDK70346.1 - 0.0025 17.3 0.0 0.0037 16.7 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Annexin PF00191.20 VDK70346.1 - 0.019 15.0 0.7 2.9 8.0 0.0 2.3 2 0 0 2 2 2 0 Annexin PRTase_2 PF15609.6 VDK70346.1 - 0.18 11.3 0.0 0.45 10.0 0.0 1.7 2 0 0 2 2 2 0 Phosphoribosyl transferase Zip PF02535.22 VDK70348.1 - 1.1e-67 228.6 6.9 1.5e-67 228.2 6.9 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF1129 PF06570.11 VDK70348.1 - 0.067 12.7 9.7 0.36 10.3 2.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) DUF4212 PF13937.6 VDK70348.1 - 0.6 10.5 7.9 7.9 6.9 0.5 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4212) CitMHS PF03600.16 VDK70348.1 - 2.9 7.0 10.3 0.2 10.8 1.6 2.3 2 0 0 2 2 2 0 Citrate transporter PDZ PF00595.24 VDK70350.1 - 2.4e-21 75.8 1.5 1.9e-12 47.3 0.2 3.0 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 VDK70350.1 - 5.6e-14 51.7 0.1 1.4e-06 28.0 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDK70350.1 - 7.1e-06 26.3 0.5 0.014 15.7 0.0 2.7 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 VDK70351.1 - 9.8e-10 38.7 0.0 1.1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK70351.1 - 3.6e-09 36.3 0.0 5.4e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK70351.1 - 5.2e-08 33.1 0.0 7e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDK70353.1 - 8.8e-16 58.0 0.0 1.2e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK70353.1 - 4e-09 36.2 0.0 5.3e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK70353.1 - 1.9e-05 24.9 0.0 2.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 PDZ domain Ribosomal_L31e PF01198.19 VDK70356.1 - 9.2e-42 141.2 0.5 1.4e-41 140.6 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e Vsr PF03852.15 VDK70356.1 - 0.017 14.9 0.3 0.15 11.9 0.0 2.0 1 1 1 2 2 2 0 DNA mismatch endonuclease Vsr T4_baseplate PF12322.8 VDK70357.1 - 0.017 14.6 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 T4 bacteriophage base plate protein E1-E2_ATPase PF00122.20 VDK70357.1 - 1.7 8.2 0.0 1.7 8.2 0.0 2.8 3 0 0 3 3 3 0 E1-E2 ATPase Thioredoxin PF00085.20 VDK70358.1 - 1.6e-85 281.8 0.1 5.2e-21 74.6 0.0 6.2 6 0 0 6 6 6 5 Thioredoxin DnaJ PF00226.31 VDK70358.1 - 2.7e-20 72.2 2.1 5.4e-20 71.3 2.1 1.5 1 0 0 1 1 1 1 DnaJ domain Thioredoxin_8 PF13905.6 VDK70358.1 - 6.2e-15 55.3 3.6 0.0013 19.0 0.0 7.0 6 2 2 8 8 8 4 Thioredoxin-like Thioredoxin_6 PF13848.6 VDK70358.1 - 7.6e-14 52.0 0.0 2.8e-07 30.6 0.0 4.0 3 1 1 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.13 VDK70358.1 - 4.2e-13 49.3 0.1 5.2e-06 26.0 0.0 4.4 4 0 0 4 4 4 3 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 VDK70358.1 - 2.1e-12 47.5 3.9 0.0034 17.8 0.0 6.5 5 3 0 5 5 5 2 Thioredoxin-like domain AhpC-TSA PF00578.21 VDK70358.1 - 1.9e-08 34.3 2.5 0.014 15.3 0.0 4.7 5 0 0 5 5 5 3 AhpC/TSA family Redoxin PF08534.10 VDK70358.1 - 1.4e-07 31.3 0.7 0.016 14.9 0.0 4.2 4 0 0 4 4 4 2 Redoxin Thioredoxin_7 PF13899.6 VDK70358.1 - 1.6e-07 31.4 1.5 0.47 10.7 0.0 4.3 4 0 0 4 4 4 2 Thioredoxin-like Thioredoxin_3 PF13192.6 VDK70358.1 - 8e-06 25.8 0.3 0.084 12.9 0.0 4.0 4 0 0 4 4 4 1 Thioredoxin domain Thioredoxin_9 PF14595.6 VDK70358.1 - 4.2e-05 23.3 3.5 1.7 8.4 0.0 4.2 4 0 0 4 4 4 2 Thioredoxin TraF PF13728.6 VDK70358.1 - 0.0009 19.1 0.5 0.24 11.2 0.0 3.2 3 0 0 3 3 3 1 F plasmid transfer operon protein Thioredoxin_5 PF13743.6 VDK70358.1 - 0.0098 15.6 0.3 16 5.1 0.0 3.6 3 0 0 3 3 3 0 Thioredoxin DDE_Tnp_1_2 PF13586.6 VDK70358.1 - 0.038 14.4 0.0 2.6 8.5 0.0 3.3 3 1 0 3 3 3 0 Transposase DDE domain Glutaredoxin PF00462.24 VDK70358.1 - 1.3 9.3 8.0 8.9 6.6 0.0 4.1 4 0 0 4 4 3 0 Glutaredoxin XPG_I PF00867.18 VDK70360.1 - 5.5e-30 103.6 0.1 1.3e-29 102.4 0.1 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 VDK70360.1 - 8.1e-30 103.3 0.0 5.6e-29 100.6 0.0 2.4 2 1 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.20 VDK70360.1 - 1.2e-06 29.0 0.0 9.9e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Exo84_C PF16528.5 VDK70363.1 - 4.3e-24 85.5 1.3 3.9e-23 82.4 0.0 2.4 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 VDK70363.1 - 1.2e-11 44.5 2.9 3.4e-11 43.1 2.9 1.8 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 VDK70363.1 - 0.011 15.8 2.6 0.016 15.3 0.9 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 PH PF00169.29 VDK70363.1 - 0.019 15.4 0.0 0.039 14.5 0.0 1.6 1 0 0 1 1 1 0 PH domain DUF1356 PF07092.12 VDK70364.1 - 1.3e-38 132.6 1.6 1.6e-38 132.3 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 VDK70364.1 - 0.002 18.0 0.1 0.0045 16.9 0.1 1.6 1 0 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein Ribosomal_60s PF00428.19 VDK70366.1 - 2.2e-22 79.4 3.0 3e-22 79.0 3.0 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein MPP6 PF10175.9 VDK70366.1 - 0.056 13.9 0.5 0.09 13.3 0.5 1.3 1 1 0 1 1 1 0 M-phase phosphoprotein 6 DMAP1_like PF17024.5 VDK70366.1 - 0.14 12.2 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative DMAP1-like Activin_recp PF01064.23 VDK70368.1 - 0.0011 20.0 11.7 0.0014 19.7 11.7 1.1 1 0 0 1 1 1 1 Activin types I and II receptor domain Toxin_TOLIP PF00087.21 VDK70368.1 - 0.54 10.5 14.7 0.95 9.8 14.7 1.4 1 1 0 1 1 1 0 Snake toxin and toxin-like protein SAM_2 PF07647.17 VDK70369.1 - 6.3e-08 32.6 1.4 2.1e-06 27.7 0.1 3.5 4 1 1 5 5 5 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 VDK70369.1 - 5.3e-05 23.6 0.0 0.00034 21.0 0.0 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Granulin PF00396.18 VDK70371.1 - 3.8e-13 49.5 20.3 3.8e-13 49.5 20.3 2.6 2 1 1 3 3 3 1 Granulin BRCT PF00533.26 VDK70372.1 - 2.2e-08 34.4 0.2 0.00072 19.9 0.0 3.0 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 VDK70372.1 - 2.6e-06 27.3 0.3 0.0002 21.3 0.0 2.8 2 0 0 2 2 2 1 twin BRCT domain BRCT_3 PF18428.1 VDK70372.1 - 0.017 15.2 1.5 4.2 7.5 0.1 3.5 4 0 0 4 4 4 0 BRCA1 C Terminus (BRCT) domain RhoGEF PF00621.20 VDK70404.1 - 1.8e-33 116.3 1.4 3.3e-33 115.5 1.4 1.4 1 0 0 1 1 1 1 RhoGEF domain Com_YlbF PF06133.11 VDK70404.1 - 0.14 12.8 1.9 0.22 12.2 0.1 2.3 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA SH3_9 PF14604.6 VDK70407.1 - 2.6e-06 27.2 0.0 3.8e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK70407.1 - 3.1e-05 23.5 0.0 5.2e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK70407.1 - 0.0047 16.6 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 VDK70407.1 - 0.13 12.5 0.2 0.25 11.6 0.1 1.5 2 0 0 2 2 2 0 Bacterial SH3 domain RhoGEF PF00621.20 VDK70409.1 - 5.7e-29 101.7 5.6 5.7e-29 101.7 5.6 2.3 2 1 0 2 2 2 1 RhoGEF domain Myc-LZ PF02344.15 VDK70409.1 - 1.2 9.3 6.6 0.21 11.7 1.6 2.4 2 0 0 2 2 2 0 Myc leucine zipper domain Spectrin PF00435.21 VDK70411.1 - 2.6e-17 63.2 33.0 4.7e-06 27.0 0.9 7.5 6 2 1 7 7 7 3 Spectrin repeat CRAL_TRIO PF00650.20 VDK70411.1 - 7.9e-08 32.2 0.0 2.8e-07 30.4 0.0 2.0 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 VDK70411.1 - 0.0014 18.8 0.0 0.0032 17.6 0.0 1.6 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain NAD_binding_9 PF13454.6 VDK70411.1 - 0.041 13.9 0.2 0.52 10.3 0.1 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Filo_VP35 PF02097.15 VDK70411.1 - 0.13 11.2 0.9 0.27 10.2 0.9 1.4 1 0 0 1 1 1 0 Filoviridae VP35 PCMT PF01135.19 VDK70413.1 - 9.4e-24 84.3 0.0 2.1e-23 83.2 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SOCS_box PF07525.16 VDK70413.1 - 0.0034 17.7 0.1 1.8 9.0 0.0 2.6 2 0 0 2 2 2 2 SOCS box Methyltransf_31 PF13847.6 VDK70413.1 - 0.015 15.1 0.0 0.047 13.5 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Phage_DNA_bind PF02303.17 VDK70413.1 - 0.092 13.0 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 Helix-destabilising protein PID PF00640.23 VDK70414.1 - 4.6e-41 140.1 0.1 1e-40 139.0 0.1 1.6 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PDZ PF00595.24 VDK70414.1 - 7.6e-16 58.2 3.4 1e-11 45.0 0.2 3.4 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 VDK70414.1 - 1.1e-06 28.4 0.6 7.8e-05 22.4 0.1 2.7 2 0 0 2 2 2 1 PDZ domain SprA-related PF12118.8 VDK70414.1 - 0.061 12.5 10.3 0.11 11.6 10.3 1.4 1 0 0 1 1 1 0 SprA-related family Ndc1_Nup PF09531.10 VDK70414.1 - 0.15 10.7 5.0 0.21 10.3 5.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PRIMA1 PF16101.5 VDK70414.1 - 0.25 11.4 9.5 0.66 10.0 9.5 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Hamartin PF04388.12 VDK70414.1 - 0.36 9.4 12.8 0.46 9.1 12.8 1.2 1 0 0 1 1 1 0 Hamartin protein Tubulin_C PF03953.17 VDK70416.1 - 0.15 12.2 1.7 0.22 11.7 0.4 1.9 2 0 0 2 2 2 0 Tubulin C-terminal domain CfAFP PF05264.11 VDK70416.1 - 1.2 9.1 9.3 0.11 12.5 2.6 2.4 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) RPN7 PF10602.9 VDK70417.1 - 0.011 15.4 3.9 0.098 12.4 0.2 3.3 3 0 0 3 3 3 0 26S proteasome subunit RPN7 SNAP PF14938.6 VDK70417.1 - 0.014 14.8 1.3 11 5.3 0.4 3.1 3 0 0 3 3 3 0 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 VDK70417.1 - 0.021 15.1 1.8 12 6.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2935 PF11155.8 VDK70417.1 - 0.13 12.6 3.6 3.1 8.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) TPR_2 PF07719.17 VDK70417.1 - 0.59 10.4 5.0 16 5.9 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK70417.1 - 0.75 10.4 3.0 6.7 7.3 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK70417.1 - 1.9 8.9 6.7 67 4.1 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ComR_TPR PF18710.1 VDK70417.1 - 8.3 5.9 9.1 2.1 7.9 0.3 3.4 3 1 1 4 4 4 0 ComR tetratricopeptide Lectin_C PF00059.21 VDK70418.1 - 3.2e-09 37.5 0.6 4.9e-09 36.9 0.0 1.6 2 0 0 2 2 2 1 Lectin C-type domain Ribosomal_L4 PF00573.22 VDK70419.1 - 0.29 10.8 0.0 0.29 10.8 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L4/L1 family DUF4773 PF15998.5 VDK70420.1 - 4.9e-13 49.6 9.6 5.4e-10 39.8 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4773) Asparaginase_2 PF01112.18 VDK70421.1 - 3.7e-66 223.2 0.0 4.1e-66 223.1 0.0 1.0 1 0 0 1 1 1 1 Asparaginase ANTH PF07651.16 VDK70422.1 - 7.9e-69 231.7 0.4 1.1e-68 231.3 0.4 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 VDK70422.1 - 2.5e-13 50.1 0.1 4.9e-13 49.2 0.1 1.5 1 0 0 1 1 1 1 ENTH domain Lectin_C PF00059.21 VDK70458.1 - 0.00065 20.4 0.3 0.0012 19.6 0.3 1.5 1 0 0 1 1 1 1 Lectin C-type domain ImpA_N PF06812.12 VDK70458.1 - 0.0087 16.2 0.1 0.02 15.0 0.1 1.6 1 0 0 1 1 1 1 ImpA, N-terminal, type VI secretion system Motile_Sperm PF00635.26 VDK70459.1 - 8.3e-16 57.8 1.0 1.8e-15 56.7 1.0 1.6 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Exo_endo_phos PF03372.23 VDK70459.1 - 3.2e-09 36.6 0.0 5.1e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ground-like PF04155.18 VDK70459.1 - 2.5e-05 24.9 0.5 8e-05 23.2 0.5 1.9 1 0 0 1 1 1 1 Ground-like domain DUF4035 PF13227.6 VDK70459.1 - 0.0059 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4035) FH2 PF02181.23 VDK70461.1 - 3.4e-28 98.8 6.5 1.9e-15 56.9 0.3 3.2 3 1 1 4 4 4 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 VDK70461.1 - 1.5e-08 34.5 1.5 6.4e-08 32.4 1.5 2.0 1 1 0 1 1 1 1 Diaphanous FH3 Domain HPP PF04982.13 VDK70461.1 - 0.21 11.8 0.1 0.43 10.8 0.1 1.4 1 0 0 1 1 1 0 HPP family PSD1 PF07587.11 VDK70461.1 - 0.22 11.0 2.5 0.51 9.8 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1553) TB2_DP1_HVA22 PF03134.19 VDK70463.1 - 7.3e-25 86.7 5.1 7.3e-25 86.7 5.1 1.9 2 1 1 3 3 3 1 TB2/DP1, HVA22 family Peptidase_S6 PF02395.16 VDK70465.1 - 0.0087 14.2 0.2 0.01 13.9 0.2 1.0 1 0 0 1 1 1 1 Immunoglobulin A1 protease F-box PF00646.33 VDK70468.1 - 0.00038 20.3 0.9 0.00069 19.4 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 VDK70468.1 - 0.0058 16.5 0.9 0.013 15.3 0.0 2.1 2 0 0 2 2 2 1 F-box-like Pkinase_Tyr PF07714.17 VDK70471.1 - 5.2e-89 297.9 0.0 7.6e-89 297.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK70471.1 - 9.7e-39 133.3 0.0 7.2e-36 123.9 0.0 2.8 2 1 0 2 2 2 2 Protein kinase domain Haspin_kinase PF12330.8 VDK70471.1 - 0.027 13.4 0.1 0.043 12.8 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 VDK70471.1 - 0.049 12.9 0.0 0.092 12.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 VDK70471.1 - 0.066 12.0 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 VDK70471.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-CCCH PF00642.24 VDK70473.1 - 8.8e-16 57.4 13.9 2e-09 37.1 2.0 2.7 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK70473.1 - 5.4e-06 26.3 11.2 0.0015 18.5 3.1 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_2 PF14608.6 VDK70473.1 - 2.3e-05 24.7 3.7 0.036 14.6 0.5 2.9 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 VDK70473.1 - 0.0013 18.5 7.4 0.26 11.1 0.7 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger SRPRB PF09439.10 VDK70473.1 - 0.04 13.3 0.0 0.084 12.3 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Torus PF16131.5 VDK70473.1 - 0.28 11.9 10.4 0.86 10.3 0.8 2.9 2 1 1 3 3 3 0 Torus domain Lustrin_cystein PF14625.6 VDK70473.1 - 3.5 8.1 8.4 6.6 7.2 0.9 2.9 2 1 1 3 3 3 0 Lustrin, cysteine-rich repeated domain zf-CCHH PF10283.9 VDK70473.1 - 5.9 7.0 10.6 6.6 6.8 1.3 2.7 2 0 0 2 2 2 0 PBZ domain Pkinase PF00069.25 VDK70478.1 - 4.5e-22 78.7 0.0 5.5e-22 78.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70478.1 - 4.4e-09 36.0 0.0 6e-09 35.6 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK70478.1 - 5.8e-05 22.0 0.0 0.00033 19.6 0.0 1.9 1 1 1 2 2 2 1 Fungal protein kinase Rbsn PF11464.8 VDK70478.1 - 0.1 12.3 0.8 0.59 9.9 0.1 2.4 2 0 0 2 2 2 0 Rabenosyn Rab binding domain zf-CCCH_2 PF14608.6 VDK70479.1 - 3.8e-10 39.9 25.5 0.00089 19.6 5.0 3.4 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger PWI PF01480.17 VDK70479.1 - 8.6e-05 22.8 0.6 0.00017 21.9 0.6 1.5 1 0 0 1 1 1 1 PWI domain AWS PF17907.1 VDK70479.1 - 0.66 10.1 3.8 1.8 8.7 3.8 1.7 1 1 0 1 1 1 0 AWS domain Innexin PF00876.18 VDK70480.1 - 5.8e-80 269.2 7.1 6.2e-70 236.2 4.8 2.1 1 1 1 2 2 2 2 Innexin L51_S25_CI-B8 PF05047.16 VDK70485.1 - 1.4e-13 50.5 0.2 1.7e-13 50.2 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain RMI1_N PF08585.12 VDK70490.1 - 2.2e-40 138.7 0.1 4.5e-40 137.7 0.1 1.4 1 0 0 1 1 1 1 RecQ mediated genome instability protein RMI1_C PF16099.5 VDK70490.1 - 3.3e-08 33.5 0.0 8.2e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold SKIP_SNW PF02731.15 VDK70492.1 - 4.3e-71 237.8 6.1 4.3e-71 237.8 6.1 1.7 2 0 0 2 2 2 1 SKIP/SNW domain Presenilin PF01080.17 VDK70492.1 - 8.8 5.0 7.4 16 4.1 7.4 1.3 1 0 0 1 1 1 0 Presenilin Ank_2 PF12796.7 VDK70526.1 - 1.5e-81 269.0 27.8 2.3e-12 47.3 0.1 8.5 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK70526.1 - 2.7e-65 216.0 25.9 1.6e-12 47.7 0.1 11.9 7 3 2 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 VDK70526.1 - 1.5e-63 208.6 38.2 4.4e-08 33.2 0.0 16.7 16 0 0 16 16 16 13 Ankyrin repeat Ank_3 PF13606.6 VDK70526.1 - 2.9e-63 202.3 26.8 1.3e-06 28.2 0.0 17.8 18 0 0 18 18 18 13 Ankyrin repeat Ank_5 PF13857.6 VDK70526.1 - 5.3e-52 173.2 34.0 6e-08 32.8 0.1 14.9 5 2 9 16 16 16 14 Ankyrin repeats (many copies) Ion_trans PF00520.31 VDK70526.1 - 1.8e-08 34.0 19.0 2e-08 33.8 17.2 2.0 2 0 0 2 2 2 1 Ion transport protein TetR_C_35 PF18556.1 VDK70527.1 - 0.14 12.3 0.1 0.22 11.7 0.1 1.3 1 0 0 1 1 1 0 Bacterial Tetracyclin repressor, C-terminal domain COX2_TM PF02790.15 VDK70528.1 - 0.0088 16.2 1.7 2.1 8.5 0.2 3.0 2 0 0 2 2 2 2 Cytochrome C oxidase subunit II, transmembrane domain GTP_EFTU PF00009.27 VDK70530.1 - 1.6e-55 187.7 0.0 2.3e-55 187.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 VDK70530.1 - 3.7e-41 139.9 0.0 9.4e-41 138.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 VDK70530.1 - 8.3e-16 58.2 1.4 1.7e-15 57.2 0.2 2.2 2 1 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 VDK70530.1 - 0.00018 21.5 0.1 0.0047 17.0 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 VDK70530.1 - 0.017 15.0 1.9 0.022 14.7 0.3 2.0 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Semialdhyde_dhC PF02774.18 VDK70530.1 - 0.049 13.7 0.4 0.13 12.3 0.2 1.8 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain AFP PF02420.15 VDK70532.1 - 0.57 10.7 3.7 3.4 8.3 3.7 2.4 1 0 0 1 1 1 0 Insect antifreeze protein repeat S4 PF01479.25 VDK70533.1 - 3.7e-11 42.6 0.1 6.1e-11 41.9 0.1 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 VDK70533.1 - 5.8e-08 33.5 0.6 9.1e-08 32.9 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain VWD PF00094.25 VDK70535.1 - 2.3e-26 93.0 0.0 3.7e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type D domain VWC PF00093.18 VDK70535.1 - 2.7e-14 53.2 62.2 2.3e-08 34.2 10.0 4.8 4 1 0 4 4 4 3 von Willebrand factor type C domain TILa PF12714.7 VDK70535.1 - 0.0051 16.7 9.5 0.0051 16.7 9.5 5.0 4 2 0 4 4 4 2 TILa domain PHTB1_N PF14727.6 VDK70536.1 - 8.7e-84 282.3 1.6 1.2e-83 281.9 1.6 1.2 1 0 0 1 1 1 1 PTHB1 N-terminus PHTB1_C PF14728.6 VDK70536.1 - 1.5e-40 139.5 2.5 2.5e-40 138.8 2.5 1.3 1 0 0 1 1 1 1 PTHB1 C-terminus ApbA_C PF08546.11 VDK70536.1 - 0.1 12.8 0.0 0.37 11.0 0.1 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal 3HCDH_N PF02737.18 VDK70537.1 - 3.8e-55 186.6 0.5 6.2e-55 185.9 0.5 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 VDK70537.1 - 5.3e-35 120.9 0.1 8.3e-35 120.3 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 VDK70537.1 - 4.7e-31 107.3 0.0 2.8e-22 79.2 0.0 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 VDK70537.1 - 1.9e-22 80.2 0.2 4.3e-22 79.1 0.1 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase DUF4588 PF15251.6 VDK70538.1 - 1.1e-08 35.2 2.0 2.3e-08 34.1 2.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) Ribosomal_S8e PF01201.22 VDK70540.1 - 1.2e-49 168.0 3.3 1.9e-49 167.4 3.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e Kdo PF06293.14 VDK70541.1 - 2e-12 46.9 0.0 3.7e-12 46.0 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 VDK70541.1 - 1.7e-09 37.5 0.1 2.6e-09 36.9 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 VDK70541.1 - 7.4e-09 35.5 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_Tyr PF07714.17 VDK70541.1 - 3.8e-05 23.1 0.0 5e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK70541.1 - 0.0012 18.8 0.0 0.0096 15.9 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 VDK70541.1 - 0.0027 17.1 0.0 0.0053 16.1 0.0 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 VDK70541.1 - 0.018 14.7 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Tfb2 PF03849.14 VDK70541.1 - 0.05 12.6 0.0 0.074 12.0 0.0 1.2 1 0 0 1 1 1 0 Transcription factor Tfb2 Pkinase_fungal PF17667.1 VDK70541.1 - 0.084 11.6 0.0 0.098 11.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Sec7_N PF12783.7 VDK70543.1 - 0.0086 16.0 0.4 0.0086 16.0 0.4 4.0 2 1 1 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT PF02985.22 VDK70543.1 - 0.06 13.6 3.5 36 5.0 0.0 5.9 6 0 0 6 6 6 0 HEAT repeat PI3Ka PF00613.20 VDK70545.1 - 2.2e-49 167.4 2.3 3.7e-49 166.6 2.3 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 VDK70545.1 - 5.2e-46 157.5 0.0 7e-32 111.2 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 VDK70545.1 - 3.2e-24 85.4 0.0 6.1e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 NuA4 PF09340.10 VDK70548.1 - 9.4e-24 83.1 0.0 1.4e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 EzrA PF06160.12 VDK70548.1 - 0.11 10.6 0.1 0.14 10.3 0.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA ATG16 PF08614.11 VDK70548.1 - 0.18 12.1 0.3 0.18 12.1 0.3 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF3618 PF12277.8 VDK70548.1 - 0.76 10.1 4.1 2.7 8.3 4.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3618) PIP49_C PF12260.8 VDK70550.1 - 2.9e-27 95.6 1.6 4.7e-27 94.9 1.6 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 PIP49_N PF14875.6 VDK70550.1 - 0.4 10.5 11.2 0.029 14.3 2.3 2.6 2 1 0 2 2 2 0 N-term cysteine-rich ER, FAM69 zf-RING_2 PF13639.6 VDK70551.1 - 2.5e-08 34.1 8.0 4.4e-08 33.3 6.6 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 VDK70551.1 - 2.1e-05 24.3 6.5 4.6e-05 23.2 6.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK70551.1 - 2.3e-05 24.1 6.3 5.8e-05 22.9 6.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK70551.1 - 0.0001 22.1 5.2 0.0001 22.1 5.2 1.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK70551.1 - 0.00056 19.9 2.9 0.00056 19.9 2.9 2.0 2 1 0 2 2 1 1 RING-type zinc-finger zf-RING_10 PF16685.5 VDK70551.1 - 0.00071 19.7 2.6 0.0013 18.9 2.6 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_5 PF14634.6 VDK70551.1 - 0.0021 18.0 5.9 0.0021 18.0 5.9 1.6 2 0 0 2 2 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 VDK70551.1 - 0.0028 17.9 4.1 0.0028 17.9 4.1 2.4 2 1 0 3 3 3 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 VDK70551.1 - 0.019 14.6 4.7 0.019 14.6 4.7 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Corona_6B_7B PF03262.13 VDK70551.1 - 0.054 12.9 0.5 0.26 10.7 0.6 1.7 1 1 0 2 2 2 0 Coronavirus 6B/7B protein Prok-RING_4 PF14447.6 VDK70551.1 - 0.14 12.1 9.1 0.28 11.1 2.0 2.5 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 VDK70551.1 - 0.22 11.3 6.7 0.11 12.2 2.2 2.6 3 0 0 3 3 3 0 RING-like zinc finger zf-RING-like PF08746.11 VDK70551.1 - 0.47 10.8 9.7 2 8.8 9.8 2.0 1 1 1 2 2 2 0 RING-like domain zf-RING_4 PF14570.6 VDK70551.1 - 0.61 9.9 7.2 4.4 7.2 7.7 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 VDK70551.1 - 0.64 10.2 6.2 2.3 8.5 6.2 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 VDK70551.1 - 0.72 9.9 7.3 0.42 10.7 4.1 2.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 VDK70551.1 - 0.83 9.6 8.3 0.44 10.5 1.9 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 RINGv PF12906.7 VDK70551.1 - 2.2 8.5 9.6 4.6 7.4 7.3 2.4 2 1 0 2 2 2 0 RING-variant domain Prok-RING_4 PF14447.6 VDK70553.1 - 0.09 12.7 4.7 0.29 11.0 4.7 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Y_phosphatase PF00102.27 VDK70557.1 - 4.2e-46 157.4 0.1 5.3e-46 157.1 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase OST3_OST6 PF04756.13 VDK70557.1 - 0.049 13.0 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family AA_permease_2 PF13520.6 VDK70558.1 - 4.7e-05 22.4 1.3 5.9e-05 22.1 1.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3377 PF11857.8 VDK70558.1 - 0.00065 19.6 0.8 0.00065 19.6 0.8 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF3377) DUF4728 PF15860.5 VDK70558.1 - 0.035 14.8 1.0 0.035 14.8 1.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4728) Gemini_mov PF01708.16 VDK70558.1 - 0.065 13.0 2.9 0.17 11.7 0.1 2.4 2 0 0 2 2 2 0 Geminivirus putative movement protein CrgA PF06781.12 VDK70558.1 - 0.095 12.8 0.2 0.095 12.8 0.2 2.3 2 1 1 3 3 3 0 Cell division protein CrgA DUF4267 PF14087.6 VDK70558.1 - 0.1 12.7 1.0 0.7 10.0 0.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4267) DUF898 PF05987.13 VDK70558.1 - 0.13 11.3 6.3 0.024 13.7 1.4 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF4079 PF13301.6 VDK70558.1 - 0.37 10.9 2.9 0.47 10.6 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) ETRAMP PF09716.10 VDK70558.1 - 0.39 10.8 4.3 2 8.5 4.0 2.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Spo7 PF03907.13 VDK70558.1 - 0.53 9.7 6.5 4.7 6.6 0.9 2.1 2 0 0 2 2 2 0 Spo7-like protein DUF3671 PF12420.8 VDK70558.1 - 1.2 9.2 10.5 0.34 11.0 7.1 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF1218 PF06749.12 VDK70558.1 - 3.8 8.1 9.0 0.89 10.1 2.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) TctB PF07331.11 VDK70558.1 - 8.5 6.6 13.2 14 5.9 7.1 2.4 1 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family ISK_Channel PF02060.15 VDK70558.1 - 9 6.0 10.9 1.4 8.6 5.9 2.2 2 1 1 3 3 3 0 Slow voltage-gated potassium channel TRP_2 PF08344.11 VDK70559.1 - 1e-09 38.5 2.7 2.5e-09 37.2 2.7 1.7 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 VDK70559.1 - 0.00015 22.3 0.0 0.00049 20.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDK70559.1 - 0.0021 18.4 5.7 0.016 15.7 0.3 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 VDK70559.1 - 0.011 16.0 0.0 0.059 13.7 0.1 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.30 VDK70559.1 - 0.17 12.4 0.3 0.17 12.4 0.3 2.7 3 0 0 3 3 3 0 Ankyrin repeat DUF2650 PF10853.8 VDK70560.1 - 1.7e-18 66.0 4.7 3.2e-18 65.1 4.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2650) AAA PF00004.29 VDK70562.1 - 5.2e-50 169.3 0.0 5.3e-40 136.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 VDK70562.1 - 5.3e-11 42.5 0.0 1.4e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 VDK70562.1 - 3.5e-10 39.5 0.1 7.7e-10 38.4 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain CDC48_2 PF02933.17 VDK70562.1 - 1.1e-07 31.6 0.1 8.7e-07 28.6 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_2 PF07724.14 VDK70562.1 - 4.3e-07 30.2 0.0 2.6e-05 24.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 VDK70562.1 - 2e-06 27.3 0.0 0.065 12.4 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain RuvB_N PF05496.12 VDK70562.1 - 4.9e-06 26.4 0.1 0.017 14.9 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK70562.1 - 6e-06 26.6 0.2 0.0013 19.1 0.1 3.8 2 2 1 3 3 3 1 AAA domain AAA_16 PF13191.6 VDK70562.1 - 8.5e-06 26.2 0.0 0.0079 16.6 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 VDK70562.1 - 2e-05 24.1 0.1 0.0074 15.7 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 VDK70562.1 - 2.6e-05 23.7 0.3 0.0054 16.1 0.1 2.6 2 0 0 2 2 2 1 KaiC AAA_18 PF13238.6 VDK70562.1 - 2.9e-05 24.6 0.0 0.032 14.8 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.14 VDK70562.1 - 5.1e-05 23.3 0.1 0.0015 18.5 0.1 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 VDK70562.1 - 7.9e-05 22.5 0.0 0.041 13.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 VDK70562.1 - 0.00014 21.9 0.0 0.12 12.3 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 VDK70562.1 - 0.00015 21.8 0.0 0.15 12.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 VDK70562.1 - 0.00021 21.5 0.0 0.14 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 VDK70562.1 - 0.00025 21.4 0.0 0.042 14.2 0.0 2.8 2 0 0 2 2 2 1 RNA helicase ATPase_2 PF01637.18 VDK70562.1 - 0.00086 19.3 0.0 3.6 7.4 0.0 3.6 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 VDK70562.1 - 0.0015 18.3 0.0 0.8 9.4 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.11 VDK70562.1 - 0.0016 18.3 0.0 0.26 11.2 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 VDK70562.1 - 0.0019 17.7 0.0 0.022 14.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 VDK70562.1 - 0.0027 17.6 0.2 3.2 7.6 0.0 4.0 4 0 0 4 4 4 1 NACHT domain KTI12 PF08433.10 VDK70562.1 - 0.0035 16.8 0.0 3.3 7.1 0.0 2.6 2 0 0 2 2 2 2 Chromatin associated protein KTI12 CPT PF07931.12 VDK70562.1 - 0.0053 16.6 0.3 0.74 9.6 0.0 3.4 3 0 0 3 3 3 1 Chloramphenicol phosphotransferase-like protein Parvo_NS1 PF01057.17 VDK70562.1 - 0.0062 15.7 0.0 0.58 9.2 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.17 VDK70562.1 - 0.0067 16.2 0.0 0.24 11.1 0.0 2.7 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 VDK70562.1 - 0.011 15.4 0.8 1.7 8.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 VDK70562.1 - 0.025 15.1 0.1 0.21 12.1 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Zeta_toxin PF06414.12 VDK70562.1 - 0.03 13.6 0.0 0.87 8.8 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 VDK70562.1 - 0.056 13.1 0.2 0.22 11.2 0.0 2.1 3 0 0 3 3 2 0 AAA domain T2SSE PF00437.20 VDK70562.1 - 0.057 12.5 0.0 6.5 5.7 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 VDK70562.1 - 0.12 12.7 0.5 1.5 9.2 0.1 2.8 3 0 0 3 3 3 0 AAA domain Fructosamin_kin PF03881.14 VDK70564.1 - 5.8e-68 229.2 0.1 9.1e-68 228.5 0.1 1.3 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 VDK70564.1 - 1.5e-06 28.3 0.0 4.8e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 VDK70564.1 - 0.029 14.0 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 RIO1 family Mito_fiss_reg PF05308.11 VDK70600.1 - 0.0043 17.2 1.8 0.0043 17.2 1.8 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator PRIMA1 PF16101.5 VDK70600.1 - 0.029 14.4 9.8 0.042 13.9 9.8 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 VDK70600.1 - 0.041 13.4 8.5 0.051 13.0 8.5 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal COMM_domain PF07258.14 VDK70603.1 - 5.6e-06 26.4 0.2 9.7e-06 25.6 0.2 1.4 1 0 0 1 1 1 1 COMM domain Pam16 PF03656.13 VDK70605.1 - 8.3e-37 126.0 0.9 1.1e-36 125.6 0.9 1.2 1 0 0 1 1 1 1 Pam16 Filaggrin PF03516.13 VDK70605.1 - 1.6 9.5 7.1 0.22 12.3 2.8 1.7 2 0 0 2 2 2 0 Filaggrin Pkinase_Tyr PF07714.17 VDK70606.1 - 5.6e-67 225.7 0.0 9.4e-67 225.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK70606.1 - 7.7e-42 143.5 0.0 1.6e-41 142.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain MRP-L28 PF09812.9 VDK70606.1 - 6.9e-34 117.3 4.0 1.2e-33 116.5 4.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 Kinase-like PF14531.6 VDK70606.1 - 0.0003 20.2 0.0 0.00048 19.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 VDK70606.1 - 0.058 12.3 0.3 0.18 10.7 0.0 1.9 2 1 0 2 2 2 0 Haspin like kinase domain FtsJ PF01728.19 VDK70607.1 - 1.6e-53 181.4 0.0 2.1e-53 181.0 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 VDK70607.1 - 0.003 17.3 0.0 0.067 13.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK70607.1 - 0.035 13.9 0.0 0.076 12.9 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain FeS_assembly_P PF01883.19 VDK70609.1 - 4.8e-13 49.1 0.3 1.6e-12 47.4 0.1 1.9 1 1 1 2 2 2 1 Iron-sulfur cluster assembly protein Reprolysin PF01421.19 VDK70611.1 - 1.5e-35 122.9 1.9 3.6e-35 121.7 1.9 1.7 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 VDK70611.1 - 4.7e-21 75.5 0.0 1e-20 74.4 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR PF08516.12 VDK70611.1 - 2.5e-19 69.8 9.7 2.5e-19 69.8 9.7 4.4 4 1 1 5 5 2 1 ADAM cysteine-rich Disintegrin PF00200.23 VDK70611.1 - 1.7e-16 60.7 25.9 1.7e-16 60.7 25.9 5.1 5 1 0 5 5 3 1 Disintegrin Reprolysin_5 PF13688.6 VDK70611.1 - 4.8e-10 39.9 2.7 4.8e-10 39.9 2.7 2.5 3 0 0 3 3 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 VDK70611.1 - 3.3e-06 26.9 1.8 9.5e-06 25.4 1.8 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 VDK70611.1 - 1.8e-05 25.2 1.6 4.1e-05 24.1 0.5 2.2 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like EGF_2 PF07974.13 VDK70611.1 - 0.00069 19.9 10.4 0.00069 19.9 10.4 5.7 4 1 0 4 4 4 1 EGF-like domain Reprolysin_2 PF13574.6 VDK70611.1 - 0.00078 19.4 0.8 0.0017 18.3 0.8 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like CD34_antigen PF06365.12 VDK70611.1 - 0.0041 16.7 0.0 0.0075 15.9 0.0 1.4 1 0 0 1 1 1 1 CD34/Podocalyxin family SIT PF15330.6 VDK70611.1 - 0.087 13.3 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM51 PF15345.6 VDK70611.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 PHtD_u1 PF16645.5 VDK70611.1 - 0.17 12.3 0.5 0.6 10.6 0.5 1.9 1 0 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein COX5A PF02284.16 VDK70612.1 - 1.5e-35 121.3 0.0 2e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Myosin_head PF00063.21 VDK70613.1 - 2.3e-234 779.6 3.8 2.9e-234 779.3 3.8 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 VDK70613.1 - 1.7e-35 122.4 1.0 3.1e-35 121.6 1.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding IQ PF00612.27 VDK70613.1 - 0.012 15.3 2.6 0.014 15.1 0.1 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif RNA_helicase PF00910.22 VDK70613.1 - 0.054 13.9 0.0 2.3 8.6 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Zeta_toxin PF06414.12 VDK70613.1 - 0.056 12.7 0.0 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 VDK70613.1 - 0.1 12.9 0.0 0.62 10.3 0.0 2.4 1 0 0 1 1 1 0 AAA domain Hpr_kinase_C PF07475.12 VDK70613.1 - 0.17 11.4 0.1 9.3 5.7 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain DIL PF01843.19 VDK70617.1 - 0.2 12.0 3.8 0.48 10.7 3.8 1.6 1 0 0 1 1 1 0 DIL domain PCI PF01399.27 VDK70619.1 - 5.8e-11 42.8 0.0 5.8e-11 42.8 0.0 4.6 5 0 0 5 5 5 2 PCI domain DUF3928 PF13065.6 VDK70619.1 - 0.033 14.9 0.3 0.14 13.0 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3928) EXS PF03124.14 VDK70622.1 - 5.8e-95 318.4 25.7 9e-95 317.8 25.7 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 VDK70622.1 - 2.5e-27 96.8 18.9 1.4e-13 51.6 4.5 3.2 1 1 2 3 3 3 3 SPX domain RWD PF05773.22 VDK70622.1 - 0.073 13.4 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 RWD domain DUF308 PF03729.13 VDK70622.1 - 2.8 8.3 8.8 0.11 12.8 2.5 2.0 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) Toxin_TOLIP PF00087.21 VDK70623.1 - 0.00012 22.2 11.0 0.00012 22.2 11.0 1.6 1 1 1 2 2 2 1 Snake toxin and toxin-like protein DSPc PF00782.20 VDK70624.1 - 4.4e-31 107.4 0.0 5.8e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK70624.1 - 0.01 15.4 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DSPn PF14671.6 VDK70624.1 - 0.051 14.0 0.0 0.074 13.5 0.0 1.3 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Galactosyl_T PF01762.21 VDK70625.1 - 4.3e-21 75.6 0.0 6.7e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Galactosyltransferase COX14 PF14880.6 VDK70628.1 - 0.17 11.7 2.9 0.31 10.9 2.9 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly CREPT PF16566.5 VDK70635.1 - 1.4e-42 145.3 3.7 1.4e-42 145.3 3.7 1.9 2 0 0 2 2 2 1 Cell-cycle alteration and expression-elevated protein in tumour CTD_bind PF04818.13 VDK70635.1 - 1.9e-13 51.0 4.4 4.8e-13 49.7 0.2 3.0 3 1 1 4 4 4 1 RNA polymerase II-binding domain. CTK3 PF12243.8 VDK70635.1 - 0.0042 17.1 1.4 0.0093 16.0 0.7 1.8 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 BEX PF04538.12 VDK70635.1 - 0.0076 16.8 0.3 0.013 16.1 0.3 1.4 1 0 0 1 1 1 1 Brain expressed X-linked like family DUF2312 PF10073.9 VDK70635.1 - 0.38 10.4 2.7 2.8 7.6 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) MMR_HSR1_Xtn PF16897.5 VDK70638.1 - 1.4e-43 147.2 1.6 2.7e-43 146.3 1.6 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 VDK70638.1 - 2e-23 82.2 0.0 3.8e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 VDK70638.1 - 4.3e-20 71.9 0.0 8.6e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK70638.1 - 7.5e-10 38.6 0.0 1.6e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 VDK70638.1 - 0.0036 17.4 2.9 0.24 11.4 0.0 2.5 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 VDK70638.1 - 0.041 13.2 0.1 0.071 12.4 0.1 1.5 1 0 0 1 1 1 0 AIG1 family UPF0158 PF03682.13 VDK70638.1 - 0.047 13.7 0.7 1.6 8.7 0.4 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0158) MeaB PF03308.16 VDK70638.1 - 0.32 10.0 0.0 0.32 10.0 0.0 2.0 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Sdh5 PF03937.16 VDK70640.1 - 9.2e-20 70.4 1.7 1.3e-19 69.9 0.9 1.6 2 1 0 2 2 2 1 Flavinator of succinate dehydrogenase TM2 PF05154.16 VDK70642.1 - 1.3e-10 41.4 9.1 1.3e-10 41.4 9.1 2.1 1 1 0 1 1 1 1 TM2 domain Pyridoxal_deC PF00282.19 VDK70644.1 - 6.8e-123 410.1 0.0 8.2e-123 409.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 VDK70644.1 - 8.4e-06 25.0 0.0 2.8e-05 23.3 0.0 1.8 2 1 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 VDK70644.1 - 9.4e-05 21.8 0.0 0.00015 21.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 VDK70644.1 - 0.0043 16.4 0.0 0.0065 15.8 0.0 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Merozoite_SPAM PF07133.11 VDK70644.1 - 0.0056 16.7 0.7 0.0085 16.1 0.7 1.2 1 0 0 1 1 1 1 Merozoite surface protein (SPAM) SNARE_assoc PF09335.11 VDK70645.1 - 5.7e-09 36.5 0.8 2.6e-08 34.4 0.8 2.3 1 1 0 1 1 1 1 SNARE associated Golgi protein Babuvirus_MP PF07234.11 VDK70645.1 - 0.03 14.5 2.3 0.22 11.7 0.2 2.4 2 0 0 2 2 2 0 Movement and RNA silencing protein NopRA1 PF16201.5 VDK70646.1 - 1.2e-41 142.6 2.7 2.5e-41 141.5 2.7 1.6 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 RRM_1 PF00076.22 VDK70647.1 - 1.8e-32 110.9 0.2 5.9e-15 54.8 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.11 VDK70647.1 - 2.6e-05 24.4 23.7 4.1e-05 23.8 23.7 1.2 1 0 0 1 1 1 1 Fruit fly transformer protein RRM_occluded PF16842.5 VDK70647.1 - 8.1e-05 22.4 0.0 4.8 7.1 0.0 3.5 3 0 0 3 3 3 3 Occluded RNA-recognition motif RRM_7 PF16367.5 VDK70647.1 - 0.00037 20.6 0.0 0.041 14.0 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif PRP38_assoc PF12871.7 VDK70647.1 - 0.0098 16.5 49.2 0.022 15.3 49.2 1.5 1 0 0 1 1 1 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Apt1 PF10351.9 VDK70647.1 - 0.0099 14.8 6.2 0.013 14.4 6.2 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain RRM_9 PF18444.1 VDK70647.1 - 0.13 12.1 0.1 0.8 9.6 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif Pes-10 PF07149.11 VDK70647.1 - 0.21 10.6 2.5 0.37 9.8 2.5 1.3 1 0 0 1 1 1 0 Pes-10 CDC45 PF02724.14 VDK70647.1 - 0.41 8.9 22.3 0.6 8.3 22.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 VDK70647.1 - 0.76 8.5 9.1 1.1 8.0 9.1 1.1 1 0 0 1 1 1 0 Presenilin Dsh_C PF12316.8 VDK70647.1 - 2.2 8.7 4.6 3.6 7.9 4.6 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal UQ_con PF00179.26 VDK70648.1 - 1e-30 106.2 0.1 1.2e-30 106.0 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 VDK70648.1 - 0.0007 19.9 0.2 0.001 19.3 0.2 1.4 1 1 0 1 1 1 1 RWD domain Glyco_transf_92 PF01697.27 VDK70649.1 - 3.6e-34 118.6 0.2 5.5e-34 118.0 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 92 Kelch_1 PF01344.25 VDK70650.1 - 3.1e-53 177.1 3.9 1.4e-13 50.2 0.0 6.3 6 0 0 6 6 6 6 Kelch motif BACK PF07707.15 VDK70650.1 - 1.9e-32 111.4 0.1 4.3e-32 110.3 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 VDK70650.1 - 6.6e-25 87.5 0.2 1.3e-24 86.6 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_6 PF13964.6 VDK70650.1 - 1.5e-21 75.9 1.0 0.00036 20.7 0.0 6.5 4 1 3 7 7 7 4 Kelch motif Kelch_4 PF13418.6 VDK70650.1 - 1.4e-15 57.1 5.5 0.004 17.1 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 VDK70650.1 - 9.5e-13 48.1 3.5 0.02 15.1 0.0 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 VDK70650.1 - 2.8e-11 42.9 3.2 0.11 12.5 0.3 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 VDK70650.1 - 5.8e-05 23.0 3.9 4.2 7.5 0.0 5.5 4 1 1 5 5 5 1 Kelch motif SH3_2 PF07653.17 VDK70650.1 - 0.0039 16.8 0.0 0.0097 15.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain zf-C3HC4_3 PF13920.6 VDK70651.1 - 2.8e-10 39.9 5.6 3.9e-10 39.4 5.6 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK70651.1 - 8e-10 38.4 6.0 1.1e-09 38.0 6.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK70651.1 - 2.6e-09 37.3 9.1 3.6e-09 36.8 9.1 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK70651.1 - 1.2e-08 34.7 8.5 1.7e-08 34.1 8.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK70651.1 - 7.4e-08 32.3 4.7 5.7e-07 29.5 2.4 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 VDK70651.1 - 1.6e-07 31.1 6.9 2.3e-07 30.6 6.9 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 VDK70651.1 - 1.2e-06 28.4 5.3 1.8e-06 27.8 5.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 VDK70651.1 - 4.4e-05 23.5 2.4 6.7e-05 22.9 2.4 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 VDK70651.1 - 0.00018 21.6 6.7 0.00028 21.0 6.7 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 VDK70651.1 - 0.00032 20.9 9.0 0.0006 20.0 9.0 1.4 1 1 0 1 1 1 1 RING-H2 zinc finger domain Rtf2 PF04641.12 VDK70651.1 - 0.00075 18.9 0.0 0.00096 18.6 0.0 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Baculo_IE-1 PF05290.11 VDK70651.1 - 0.011 15.7 1.1 0.02 14.8 1.1 1.4 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-UDP PF14569.6 VDK70651.1 - 0.022 14.8 1.0 0.048 13.8 1.0 1.6 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 VDK70651.1 - 0.038 13.8 5.6 0.08 12.8 5.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain IBR PF01485.21 VDK70651.1 - 0.067 13.4 7.2 0.15 12.3 2.8 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-RING_6 PF14835.6 VDK70651.1 - 0.1 12.5 3.1 0.18 11.7 3.1 1.3 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 VDK70651.1 - 0.35 10.5 5.1 0.63 9.7 5.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 VDK70651.1 - 7 6.5 9.4 1.8 8.4 5.1 2.2 2 1 0 2 2 2 0 RING-like zinc finger zf-rbx1 PF12678.7 VDK70652.1 - 1.8e-06 28.1 5.2 5.6e-06 26.6 5.2 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 VDK70652.1 - 2.1e-06 28.0 6.4 2.1e-06 28.0 6.4 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 VDK70652.1 - 0.00014 21.6 5.9 0.00049 19.9 5.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK70652.1 - 0.00085 19.2 6.5 0.00085 19.2 6.5 1.9 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK70652.1 - 0.0019 18.0 3.4 0.0044 16.8 3.4 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Di19 PF05605.12 VDK70652.1 - 0.0054 17.0 2.5 0.037 14.3 0.5 2.6 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-RING_11 PF17123.5 VDK70652.1 - 0.0073 16.0 4.0 0.013 15.3 2.1 2.5 2 1 0 2 2 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 VDK70652.1 - 0.016 15.3 4.1 0.049 13.7 4.1 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 VDK70652.1 - 0.042 13.9 2.2 0.1 12.7 2.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 VDK70652.1 - 0.079 12.8 5.3 0.26 11.2 5.3 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK70652.1 - 0.14 12.2 7.2 0.064 13.3 3.6 2.4 2 1 0 2 2 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 VDK70652.1 - 0.14 11.8 6.4 0.48 10.1 6.4 1.9 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 VDK70652.1 - 0.14 12.4 11.5 1.6 8.9 7.6 3.3 2 1 0 2 2 2 0 FANCL C-terminal domain zf-C3HC4_2 PF13923.6 VDK70652.1 - 0.38 10.6 11.9 0.07 13.0 6.5 2.7 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.6 VDK70652.1 - 1.6 8.3 5.2 4.9 6.7 0.2 2.6 3 0 0 3 3 3 0 zinc-ribbon domain DUF2040 PF09745.9 VDK70653.1 - 4.7e-32 110.6 22.4 7.5e-32 109.9 22.4 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 55 (DUF2040) DUF4407 PF14362.6 VDK70653.1 - 0.22 10.9 9.9 0.28 10.5 9.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Alpha-2-MRAP_C PF06401.11 VDK70705.1 - 1.4e-28 100.3 29.4 1.4e-28 100.3 29.4 3.0 2 2 0 2 2 2 1 Alpha-2-macroglobulin RAP, C-terminal domain Alpha-2-MRAP_N PF06400.11 VDK70705.1 - 2.4e-11 43.7 37.8 2.1e-07 30.9 2.7 4.1 1 1 2 3 3 3 2 Alpha-2-macroglobulin RAP, N-terminal domain DUF148 PF02520.17 VDK70705.1 - 0.0025 17.9 0.9 0.0025 17.9 0.9 3.1 3 2 0 3 3 3 1 Domain of unknown function DUF148 Rx_N PF18052.1 VDK70705.1 - 0.14 12.4 0.3 0.14 12.4 0.3 4.3 3 2 1 4 4 4 0 Rx N-terminal domain DUF3336 PF11815.8 VDK70707.1 - 0.067 12.9 0.9 0.11 12.2 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) SID-1_RNA_chan PF13965.6 VDK70709.1 - 3.4e-20 72.0 16.3 4.1e-18 65.1 13.6 3.0 1 1 1 2 2 2 2 dsRNA-gated channel SID-1 LSM PF01423.22 VDK70714.1 - 7.4e-21 73.6 1.0 8.4e-21 73.4 1.0 1.1 1 0 0 1 1 1 1 LSM domain EB1 PF03271.17 VDK70715.1 - 6.7e-14 51.9 0.8 1.4e-13 50.9 0.8 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 VDK70715.1 - 1.4e-08 34.8 0.9 2.5e-08 34.0 0.9 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK70715.1 - 0.017 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain CortBP2 PF09727.9 VDK70715.1 - 0.099 12.5 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Cortactin-binding protein-2 DUF2171 PF09939.9 VDK70715.1 - 0.11 12.8 0.2 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2171) Pkinase PF00069.25 VDK70716.1 - 8.7e-62 208.9 0.0 1.1e-61 208.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70716.1 - 2.9e-39 134.9 0.0 4.3e-39 134.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK70716.1 - 1.6e-08 34.3 0.0 2.2e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 VDK70716.1 - 0.018 15.0 0.2 3.2 7.6 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family zf-C2H2_4 PF13894.6 VDK70717.1 - 2.6e-08 34.0 23.0 0.033 15.0 0.2 4.8 5 0 0 5 5 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK70717.1 - 1.9e-07 31.2 16.0 0.0032 17.8 0.5 5.1 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 VDK70717.1 - 1.7e-06 28.2 4.3 0.033 14.5 0.3 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 VDK70717.1 - 3.1e-06 27.3 22.8 0.036 14.5 0.2 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-Di19 PF05605.12 VDK70717.1 - 8.9e-06 25.9 8.8 0.00024 21.3 1.5 3.3 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 VDK70717.1 - 0.0048 17.3 0.7 0.0048 17.3 0.7 4.1 4 0 0 4 4 4 1 Zinc-finger of C2H2 type CpXC PF14353.6 VDK70717.1 - 0.0077 16.3 5.8 1.3 9.1 0.0 3.2 1 1 0 2 2 2 1 CpXC protein zf-H2C2_5 PF13909.6 VDK70717.1 - 0.0081 15.9 0.3 0.0081 15.9 0.3 3.8 4 0 0 4 4 4 1 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 VDK70717.1 - 0.06 13.1 0.9 0.06 13.1 0.9 3.2 4 0 0 4 4 2 0 zinc-finger C2H2-type zf-piccolo PF05715.13 VDK70717.1 - 0.069 13.3 1.1 0.17 12.0 0.2 2.2 2 0 0 2 2 1 0 Piccolo Zn-finger DZR PF12773.7 VDK70717.1 - 0.11 12.5 5.2 2.2 8.4 5.1 2.4 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 VDK70717.1 - 0.24 11.4 2.5 1.7 8.7 2.5 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Sec23_Sec24 PF04810.15 VDK70717.1 - 0.5 10.5 0.1 0.5 10.5 0.1 3.1 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger zf-C2H2_2 PF12756.7 VDK70717.1 - 0.57 10.5 10.5 6.4 7.2 0.2 3.5 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF629 PF04780.12 VDK70717.1 - 0.76 8.2 6.4 5.5 5.4 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF629) Zn-C2H2_12 PF18112.1 VDK70717.1 - 0.95 10.0 7.8 6.5 7.3 0.4 3.2 4 0 0 4 4 2 0 Autophagy receptor zinc finger-C2H2 domain Lar_restr_allev PF14354.6 VDK70717.1 - 1.7 9.1 6.6 1.9 8.9 0.2 3.1 3 0 0 3 3 3 0 Restriction alleviation protein Lar zf_UBZ PF18439.1 VDK70717.1 - 1.7 8.3 7.5 2.2 7.9 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger DUF3449 PF11931.8 VDK70717.1 - 4.7 7.0 6.8 1.3 8.8 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) zf-BED PF02892.15 VDK70717.1 - 4.9 7.3 12.6 0.39 10.8 0.5 3.1 1 1 2 3 3 3 0 BED zinc finger zf-TRAF PF02176.18 VDK70717.1 - 6.5 7.5 13.1 14 6.5 3.0 3.4 2 1 1 3 3 3 0 TRAF-type zinc finger DUF4379 PF14311.6 VDK70717.1 - 7.8 7.0 9.4 12 6.4 3.9 2.7 1 1 2 3 3 3 0 Probable Zinc-ribbon domain ABC_membrane PF00664.23 VDK70718.1 - 3.8e-41 141.6 10.3 5.5e-41 141.0 10.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 VDK70718.1 - 1.3e-33 116.4 0.0 2.3e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 VDK70718.1 - 7.8e-08 32.0 2.4 1.6e-05 24.5 2.4 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 VDK70718.1 - 0.0011 19.3 0.1 0.0068 16.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 VDK70718.1 - 0.0011 18.7 0.1 0.0027 17.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 VDK70718.1 - 0.0013 19.1 0.0 0.004 17.6 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 VDK70718.1 - 0.003 16.4 1.7 0.0075 15.1 0.3 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_15 PF13175.6 VDK70718.1 - 0.0043 16.8 0.1 0.0068 16.2 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 VDK70718.1 - 0.0048 16.8 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase Zeta_toxin PF06414.12 VDK70718.1 - 0.0079 15.5 0.0 0.018 14.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin DUF87 PF01935.17 VDK70718.1 - 0.012 15.7 0.1 0.029 14.5 0.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_18 PF13238.6 VDK70718.1 - 0.014 15.9 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 VDK70718.1 - 0.022 14.6 0.1 0.04 13.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 VDK70718.1 - 0.027 15.0 0.0 0.06 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 VDK70718.1 - 0.028 14.0 0.1 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 VDK70718.1 - 0.053 13.4 0.6 11 5.9 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA PF00004.29 VDK70718.1 - 0.064 13.7 0.4 0.91 9.9 0.4 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) tRNA_lig_kinase PF08303.11 VDK70718.1 - 0.077 13.1 0.1 0.2 11.8 0.0 1.6 2 0 0 2 2 1 0 tRNA ligase kinase domain TRAP_beta PF05753.14 VDK70718.1 - 0.083 12.3 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) AAA_7 PF12775.7 VDK70718.1 - 0.093 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 VDK70718.1 - 0.12 12.0 0.0 1.3 8.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 VDK70718.1 - 0.12 12.3 0.0 0.44 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 VDK70718.1 - 0.16 11.7 0.1 0.77 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 VDK70718.1 - 0.16 12.3 0.0 0.46 10.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Pkinase PF00069.25 VDK70720.1 - 5.7e-69 232.4 0.0 7.4e-69 232.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70720.1 - 7.9e-33 113.8 0.0 1e-32 113.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK70720.1 - 3.3e-06 26.6 0.0 5.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK70720.1 - 2e-05 24.0 0.0 2.8e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 VDK70720.1 - 0.0054 16.3 0.2 0.0099 15.5 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.11 VDK70720.1 - 0.015 14.3 1.1 0.081 11.9 0.1 2.1 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 VDK70720.1 - 0.059 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase AA_permease_2 PF13520.6 VDK70721.1 - 0.0072 15.2 0.0 0.0088 14.9 0.0 1.1 1 0 0 1 1 1 1 Amino acid permease Glyco_hydro_20 PF00728.22 VDK70723.1 - 8.3e-11 41.9 0.0 1.5e-10 41.0 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Frizzled PF01534.17 VDK70725.1 - 7.2e-112 373.6 24.3 1.2e-111 372.9 24.3 1.3 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 VDK70725.1 - 1.3e-24 87.0 3.4 3e-24 85.8 3.4 1.6 1 0 0 1 1 1 1 Fz domain DUF2269 PF10027.9 VDK70725.1 - 0.0017 18.4 7.5 0.0022 18.1 5.0 2.3 1 1 1 2 2 2 1 Predicted integral membrane protein (DUF2269) HemY_N PF07219.13 VDK70725.1 - 2.7 8.2 6.0 0.88 9.8 1.0 2.5 2 0 0 2 2 2 0 HemY protein N-terminus Peptidase_C13 PF01650.18 VDK70726.1 - 6.5e-107 356.8 0.8 9.7e-107 356.2 0.8 1.2 1 0 0 1 1 1 1 Peptidase C13 family IZUMO PF15005.6 VDK70726.1 - 0.0038 17.8 0.2 0.0083 16.6 0.2 1.6 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated TM1586_NiRdase PF14512.6 VDK70726.1 - 0.027 14.0 0.2 0.068 12.7 0.2 1.6 1 0 0 1 1 1 0 Putative TM nitroreductase Forkhead PF00250.18 VDK70727.1 - 6.3e-06 26.4 0.3 1.6e-05 25.1 0.1 1.8 2 0 0 2 2 2 1 Forkhead domain ARF7EP_C PF14949.6 VDK70727.1 - 0.00058 20.4 0.4 0.0012 19.5 0.4 1.4 1 0 0 1 1 1 1 ARF7 effector protein C-terminus DUF3185 PF11381.8 VDK70729.1 - 0.0076 16.2 1.8 0.42 10.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3185) L_HMGIC_fpl PF10242.9 VDK70729.1 - 0.039 14.2 5.9 0.056 13.6 5.9 1.1 1 0 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein Phage_holin_3_6 PF07332.11 VDK70729.1 - 0.16 12.0 8.7 0.22 11.6 8.7 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2207 PF09972.9 VDK70729.1 - 2.5 6.8 5.1 3.2 6.4 5.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Cyt_bd_oxida_I PF01654.17 VDK70729.1 - 8.3 4.9 7.7 11 4.5 7.7 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I SH2 PF00017.24 VDK70730.1 - 2.4e-08 33.9 0.0 4.8e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 SH2 domain SH2_2 PF14633.6 VDK70730.1 - 0.011 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 SH2 domain DUF1444 PF07285.11 VDK70731.1 - 0.047 13.3 0.3 0.075 12.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1444) DUF1776 PF08643.10 VDK70731.1 - 0.14 11.5 1.0 0.31 10.4 1.0 1.5 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) HLH PF00010.26 VDK70775.1 - 0.0039 17.1 0.3 0.0075 16.2 0.3 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SR-25 PF10500.9 VDK70775.1 - 0.025 14.2 2.5 0.035 13.7 2.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HLH PF00010.26 VDK70776.1 - 9.7e-05 22.3 0.2 0.00015 21.7 0.2 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Dzip-like_N PF13815.6 VDK70776.1 - 0.0051 16.8 0.2 0.0073 16.3 0.2 1.3 1 1 0 1 1 1 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal TTRAP PF14203.6 VDK70776.1 - 0.014 15.3 0.2 0.023 14.7 0.2 1.3 1 0 0 1 1 1 0 Putative tranposon-transfer assisting protein HhH-GPD PF00730.25 VDK70777.1 - 0.028 14.9 0.0 0.096 13.2 0.0 1.9 2 0 0 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein OST-HTH PF12872.7 VDK70777.1 - 0.083 12.7 0.0 2 8.3 0.0 2.7 2 0 0 2 2 2 0 OST-HTH/LOTUS domain COesterase PF00135.28 VDK70780.1 - 3.7e-111 372.5 0.0 1.2e-110 370.9 0.0 1.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 VDK70780.1 - 5.4e-06 26.4 0.1 2.4e-05 24.3 0.1 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold zf-C4 PF00105.18 VDK70785.1 - 3.9e-09 36.8 0.3 3.9e-09 36.8 0.3 1.8 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) OrfB_Zn_ribbon PF07282.11 VDK70785.1 - 0.097 12.6 1.1 0.21 11.5 1.1 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Hormone_recep PF00104.30 VDK70787.1 - 2.6e-10 40.2 0.1 1.3e-09 37.9 0.1 1.9 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor GAGBD PF16828.5 VDK70787.1 - 0.19 11.9 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 GAG-binding domain on surface antigen DUF4440 PF14534.6 VDK70788.1 - 1.1e-12 48.3 0.0 1.2e-12 48.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 VDK70788.1 - 7.6e-08 32.9 0.0 9.2e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 VDK70788.1 - 0.00028 21.0 0.0 0.0016 18.5 0.0 1.8 1 1 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.10 VDK70788.1 - 0.00047 20.3 0.0 0.0011 19.0 0.0 1.5 1 1 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain SnoaL_3 PF13474.6 VDK70788.1 - 0.00079 19.7 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 VDK70788.1 - 0.00093 19.7 0.0 0.0047 17.5 0.0 1.9 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain YnfE PF17452.2 VDK70790.1 - 0.015 15.5 0.0 0.017 15.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized YnfE-like Zwilch PF09817.9 VDK70791.1 - 1.9e-30 105.9 0.0 3.4e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 RZZ complex, subunit zwilch Mis12 PF05859.12 VDK70791.1 - 0.00042 20.4 0.6 0.0066 16.5 0.6 2.6 1 1 0 1 1 1 1 Mis12 protein Phage_holin_3_6 PF07332.11 VDK70791.1 - 5.1 7.2 5.9 1.7 8.7 0.3 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Elongin_A PF06881.11 VDK70794.1 - 2.7e-22 79.3 0.2 2.7e-22 79.3 0.2 2.7 3 0 0 3 3 3 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Med26 PF08711.11 VDK70794.1 - 1.5e-10 40.9 0.4 5e-10 39.2 0.0 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain RRM_1 PF00076.22 VDK70795.1 - 4.5e-06 26.4 0.0 8.2e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK70795.1 - 0.0055 16.7 0.3 0.017 15.2 0.0 2.0 2 0 0 2 2 2 1 RNA binding motif Lge1 PF11488.8 VDK70797.1 - 0.027 14.7 0.1 0.045 13.9 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 TAF1_subA PF14929.6 VDK70798.1 - 7.4e-06 25.6 9.0 0.00039 20.0 9.0 2.2 1 1 0 1 1 1 1 TAF RNA Polymerase I subunit A PHF12_MRG_bd PF16737.5 VDK70798.1 - 0.00086 19.0 0.1 0.0033 17.1 0.1 1.9 2 0 0 2 2 2 1 PHD finger protein 12 MRG binding domain DUF3303 PF11746.8 VDK70828.1 - 0.039 14.2 0.0 0.072 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3303) SNF PF00209.18 VDK70829.1 - 2.8e-61 207.8 35.8 3.5e-61 207.5 35.8 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family SNF2_N PF00176.23 VDK70830.1 - 5.2e-51 173.4 0.1 9.8e-51 172.5 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK70830.1 - 1.1e-14 54.7 0.8 8.7e-14 51.8 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK70830.1 - 1.1e-09 38.5 0.1 1.1e-08 35.3 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Tropomodulin PF03250.14 VDK70830.1 - 6.5 6.8 10.5 0.2 11.7 2.3 2.8 3 0 0 3 3 3 0 Tropomodulin RGS PF00615.19 VDK70831.1 - 1.1e-10 41.8 1.1 1.7e-10 41.2 0.2 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain DIX PF00778.17 VDK70831.1 - 1.1e-09 38.0 0.0 2.8e-09 36.7 0.0 1.8 1 0 0 1 1 1 1 DIX domain SUIM_assoc PF16619.5 VDK70831.1 - 0.31 11.1 5.3 0.89 9.7 3.3 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_60s PF00428.19 VDK70832.1 - 0.0035 17.9 11.3 0.0046 17.5 11.3 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Adeno_PV PF03910.13 VDK70832.1 - 0.71 8.5 3.9 0.79 8.4 3.9 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV DUF3138 PF11336.8 VDK70832.1 - 4.2 5.9 6.3 4.5 5.8 6.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF3824 PF12868.7 VDK70832.1 - 4.8 7.8 7.6 5.9 7.6 7.6 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Peptidase_C2 PF00648.21 VDK70833.1 - 6e-123 409.6 0.0 7.5e-123 409.3 0.0 1.1 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 VDK70833.1 - 1.1e-42 145.6 0.0 2e-42 144.8 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III Aa_trans PF01490.18 VDK70837.1 - 3.9e-48 164.2 31.9 5.4e-48 163.7 31.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein UCH PF00443.29 VDK70838.1 - 5.2e-47 160.5 0.1 7.1e-47 160.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 VDK70838.1 - 3.7e-22 77.9 0.6 1.5e-20 72.7 0.3 2.7 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 VDK70838.1 - 1.2e-13 51.2 3.6 1e-12 48.2 0.0 3.1 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 VDK70838.1 - 2e-10 40.8 0.0 4.5e-10 39.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 VDK70838.1 - 0.001 18.9 0.2 0.0027 17.6 0.1 1.8 2 0 0 2 2 2 1 UBA/TS-N domain HIT PF01230.23 VDK70839.1 - 1.1e-30 106.2 0.3 1.3e-30 106.0 0.3 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 VDK70839.1 - 2.3e-23 82.8 0.1 2.8e-23 82.6 0.1 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Peptidase_C1 PF00112.23 VDK70840.1 - 2.3e-32 112.9 7.4 3.4e-32 112.3 7.4 1.4 1 0 0 1 1 1 1 Papain family cysteine protease P66_CC PF16563.5 VDK70844.1 - 2.5e-14 52.6 13.3 2.5e-14 52.6 13.3 3.4 5 0 0 5 5 5 1 Coiled-coil and interaction region of P66A and P66B with MBD2 GATA PF00320.27 VDK70844.1 - 0.0012 18.4 0.3 0.0023 17.5 0.3 1.5 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 VDK70844.1 - 0.0039 17.3 0.4 0.01 15.9 0.4 1.7 1 0 0 1 1 1 1 Zinc ribbon domain Patched PF02460.18 VDK70846.1 - 9.5e-169 563.1 12.5 4.7e-165 550.9 12.5 3.0 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK70846.1 - 4e-25 88.4 10.3 6.6e-25 87.7 7.5 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation SecD_SecF PF02355.16 VDK70846.1 - 8.9e-07 28.5 2.5 8.9e-07 28.5 2.5 3.1 3 0 0 3 3 3 1 Protein export membrane protein SLATT_fungal PF18142.1 VDK70853.1 - 0.12 12.3 0.1 0.28 11.2 0.1 1.6 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Myosin_head PF00063.21 VDK70855.1 - 2.6e-204 680.3 20.7 2.6e-170 568.0 13.5 2.4 2 0 0 2 2 2 2 Myosin head (motor domain) RhoGAP PF00620.27 VDK70855.1 - 3e-40 137.5 1.3 1.1e-39 135.8 1.3 2.0 1 0 0 1 1 1 1 RhoGAP domain IQ PF00612.27 VDK70855.1 - 1.3e-07 30.8 13.4 0.0082 15.8 0.9 4.3 3 0 0 3 3 3 3 IQ calmodulin-binding motif C1_1 PF00130.22 VDK70855.1 - 1.7e-05 24.6 19.6 2.3e-05 24.2 13.7 2.5 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RA PF00788.23 VDK70855.1 - 0.00013 22.6 0.5 0.0008 20.0 0.0 2.6 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain AAA_22 PF13401.6 VDK70855.1 - 0.00055 20.2 0.6 0.024 14.9 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 VDK70855.1 - 0.0069 16.8 3.7 0.16 12.3 0.0 3.3 2 1 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 VDK70855.1 - 0.015 14.4 0.6 0.083 11.9 0.1 2.5 3 0 0 3 3 3 0 Type II/IV secretion system protein Zf_RING PF16744.5 VDK70855.1 - 0.016 15.3 6.2 0.049 13.7 6.2 1.8 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 VDK70855.1 - 0.16 11.9 14.7 0.45 10.5 7.8 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 ABC_tran PF00005.27 VDK70855.1 - 0.21 12.1 2.3 1.9 9.0 2.3 2.8 1 1 0 1 1 1 0 ABC transporter Pkinase PF00069.25 VDK70889.1 - 1.1e-73 247.8 0.0 2.3e-36 125.5 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70889.1 - 3.6e-32 111.7 0.0 5.8e-22 78.2 0.0 3.2 3 0 0 3 3 3 2 Protein tyrosine kinase I-set PF07679.16 VDK70889.1 - 8.6e-19 67.4 0.0 2.6e-18 65.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK70889.1 - 1.6e-12 47.9 0.1 6e-12 46.0 0.1 2.0 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 VDK70889.1 - 3.8e-09 36.6 0.1 1.1e-08 35.2 0.1 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Kinase-like PF14531.6 VDK70889.1 - 2.1e-08 33.9 0.0 0.0001 21.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like fn3 PF00041.21 VDK70889.1 - 4e-08 33.5 0.1 2.6e-07 30.9 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain Ig_2 PF13895.6 VDK70889.1 - 4.8e-07 30.0 0.1 1.1e-06 28.9 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Kdo PF06293.14 VDK70889.1 - 0.00069 19.0 1.5 0.22 10.9 0.1 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Ig_C17orf99 PF17736.1 VDK70889.1 - 0.0086 16.1 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 1 C17orf99 Ig domain V-set PF07686.17 VDK70889.1 - 0.01 16.0 0.3 0.47 10.7 0.0 2.7 1 1 1 2 2 2 0 Immunoglobulin V-set domain FAD_binding_2 PF00890.24 VDK70889.1 - 0.23 10.5 0.0 0.41 9.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain PH_10 PF15411.6 VDK70892.1 - 0.0012 19.1 0.0 0.0014 18.8 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain IL2 PF00715.17 VDK70892.1 - 0.17 11.8 0.0 0.19 11.7 0.0 1.1 1 0 0 1 1 1 0 Interleukin 2 RhoGEF PF00621.20 VDK70894.1 - 4.9e-12 46.5 0.7 4.9e-12 46.5 0.7 1.7 2 0 0 2 2 2 1 RhoGEF domain SH3_2 PF07653.17 VDK70894.1 - 2.4e-06 27.1 0.0 5.4e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK70894.1 - 4.5e-05 23.0 0.0 0.00012 21.6 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 VDK70894.1 - 0.026 14.4 0.0 0.078 12.9 0.0 1.9 1 0 0 1 1 1 0 Variant SH3 domain STAR_dimer PF16544.5 VDK70895.1 - 2.5e-25 87.8 0.4 4.6e-25 86.9 0.4 1.4 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein KH_1 PF00013.29 VDK70895.1 - 7.3e-07 28.9 0.1 1.6e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 KH domain Trehalase PF01204.18 VDK70896.1 - 4.2e-154 514.2 4.2 4.8e-154 514.0 4.2 1.0 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 VDK70896.1 - 0.0062 15.5 0.6 0.014 14.3 0.0 1.7 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase Exo_endo_phos PF03372.23 VDK70897.1 - 1.1e-17 64.4 0.0 1.3e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 VDK70897.1 - 0.00082 19.2 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase WH2 PF02205.20 VDK70898.1 - 0.0016 18.2 0.1 0.0036 17.1 0.1 1.6 1 0 0 1 1 1 1 WH2 motif DUF737 PF05300.11 VDK70898.1 - 0.13 12.6 12.0 0.42 11.0 12.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF737) YabA PF06156.13 VDK70898.1 - 0.88 10.2 0.1 0.88 10.2 0.1 2.2 2 1 0 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 VDK70898.1 - 1.1 8.6 7.1 2.9 7.2 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) polyprenyl_synt PF00348.17 VDK70899.1 - 3.7e-56 190.1 0.0 4.2e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Lectin_leg-like PF03388.13 VDK70901.1 - 1.8e-74 249.9 0.0 2.6e-74 249.5 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 VDK70901.1 - 4.6e-08 33.3 0.0 9.7e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Bacterial lectin OmpH PF03938.14 VDK70901.1 - 0.043 14.2 10.5 0.11 12.8 10.5 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_23 PF13476.6 VDK70901.1 - 0.061 13.8 2.1 0.1 13.1 2.1 1.4 1 0 0 1 1 1 0 AAA domain GCN5L1 PF06320.13 VDK70901.1 - 0.14 12.3 9.9 6.4 7.0 0.0 2.6 3 0 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) DUF1664 PF07889.12 VDK70901.1 - 0.53 10.3 4.2 2.4 8.2 0.8 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 VDK70901.1 - 1.6 7.7 4.9 1.6 7.8 3.3 1.7 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMG_box PF00505.19 VDK70901.1 - 1.8 9.0 9.4 1.5 9.3 7.4 1.9 1 1 1 2 2 2 0 HMG (high mobility group) box DUF3987 PF13148.6 VDK70901.1 - 2.7 6.9 6.4 4.4 6.2 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Fib_alpha PF08702.10 VDK70901.1 - 6.4 7.0 9.2 7.9 6.7 4.5 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family ATE_C PF04377.15 VDK70903.1 - 7.3e-49 165.8 4.6 1.4e-48 165.0 4.6 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 VDK70903.1 - 9.1e-25 86.9 4.2 2.4e-22 79.1 4.2 2.8 1 1 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus CR6_interact PF10147.9 VDK70904.1 - 5.2e-22 78.6 16.4 2e-21 76.7 16.4 1.7 1 1 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 CHCH PF06747.13 VDK70906.1 - 3.3e-08 33.4 5.4 4.7e-08 33.0 5.4 1.2 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 VDK70906.1 - 0.047 14.0 3.0 0.076 13.3 3.0 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 VDK70906.1 - 0.15 12.1 2.8 0.25 11.4 2.8 1.4 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pyridoxal_deC PF00282.19 VDK70907.1 - 4.2e-114 381.2 0.0 4.1e-78 262.7 0.0 2.2 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 VDK70907.1 - 0.00011 21.5 0.0 0.00064 19.0 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 VDK70907.1 - 0.0005 19.4 0.0 0.00084 18.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 VDK70907.1 - 0.039 12.6 0.0 0.068 11.9 0.0 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Ribosomal_L30_N PF08079.12 VDK70908.1 - 7.7e-23 80.5 17.1 1.4e-22 79.7 17.1 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 VDK70908.1 - 7e-21 73.9 1.7 2.1e-20 72.4 1.7 1.9 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e ABC1 PF03109.16 VDK70908.1 - 0.0087 16.2 0.8 0.016 15.4 0.8 1.3 1 0 0 1 1 1 1 ABC1 family Ras PF00071.22 VDK70911.1 - 3.3e-63 212.1 0.5 4.1e-63 211.8 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK70911.1 - 1.9e-35 121.7 0.2 3e-35 121.0 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK70911.1 - 8.6e-13 48.1 0.1 1.2e-12 47.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK70911.1 - 1.3e-07 31.7 0.1 2e-07 31.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 VDK70911.1 - 3.7e-05 23.4 0.3 0.00016 21.3 0.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK70911.1 - 0.0001 22.3 0.2 0.018 14.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 VDK70911.1 - 0.00016 22.0 0.0 0.0036 17.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 VDK70911.1 - 0.00076 18.9 0.1 0.0013 18.1 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 VDK70911.1 - 0.012 16.0 0.1 0.022 15.2 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 VDK70911.1 - 0.016 14.6 0.0 0.029 13.8 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 VDK70911.1 - 0.024 14.7 0.1 0.06 13.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 VDK70911.1 - 0.026 15.1 0.1 0.041 14.4 0.1 1.5 1 1 0 1 1 1 0 ABC transporter FAD-SLDH PF12318.8 VDK70911.1 - 0.034 14.2 0.1 0.066 13.3 0.1 1.5 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase FeoB_N PF02421.18 VDK70911.1 - 0.035 13.6 0.2 0.068 12.7 0.2 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 VDK70911.1 - 0.037 13.8 0.0 0.11 12.3 0.0 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 VDK70911.1 - 0.071 12.5 0.1 0.24 10.8 0.0 1.9 2 1 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 VDK70911.1 - 0.096 12.4 0.1 0.2 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 VDK70911.1 - 0.1 12.9 0.2 0.97 9.7 0.2 2.1 1 1 0 1 1 1 0 AAA domain SDA1 PF05285.12 VDK70915.1 - 0.085 12.3 0.8 0.097 12.1 0.8 1.1 1 0 0 1 1 1 0 SDA1 RskA PF10099.9 VDK70915.1 - 0.1 12.9 9.2 0.034 14.4 5.1 1.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DUF3357 PF11837.8 VDK70915.1 - 2.8 8.5 6.4 0.74 10.3 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DNA_pol_phi PF04931.13 VDK70915.1 - 7.9 4.4 11.6 11 4.0 11.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF3439 PF11921.8 VDK70958.1 - 0.077 13.0 12.1 0.19 11.7 12.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 VDK70958.1 - 7.7 4.6 17.5 14 3.7 17.5 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 VHS PF00790.19 VDK70959.1 - 2.1e-29 102.2 0.1 3.9e-29 101.3 0.1 1.5 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 VDK70959.1 - 1.7e-17 62.7 0.3 5.6e-17 61.1 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 VDK70959.1 - 1.5e-11 43.8 0.0 3.4e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 VDK70959.1 - 1.7e-11 43.8 0.0 2.9e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain CutA1 PF03091.15 VDK70960.1 - 2.8e-33 113.7 0.5 3.9e-33 113.3 0.5 1.2 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein FAD_binding_8 PF08022.12 VDK70960.1 - 0.026 14.6 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 FAD-binding domain YwcE PF17368.2 VDK70960.1 - 0.029 15.0 1.4 0.055 14.1 0.1 2.0 1 1 1 2 2 2 0 Spore morphogenesis and germination YwcE COPIIcoated_ERV PF07970.12 VDK70964.1 - 9.9e-76 254.4 0.1 1.3e-75 254.1 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 VDK70964.1 - 1.8e-27 95.5 1.6 3.5e-27 94.6 0.2 2.0 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Voltage_CLC PF00654.20 VDK70968.1 - 0.016 14.5 0.2 0.024 13.9 0.2 1.2 1 0 0 1 1 1 0 Voltage gated chloride channel DUF952 PF06108.12 VDK70968.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF952) EF-hand_7 PF13499.6 VDK70972.1 - 6.8e-22 77.7 2.7 8.1e-16 58.2 0.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK70972.1 - 9.9e-21 71.7 6.8 5.4e-07 28.7 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 VDK70972.1 - 5.2e-18 63.4 6.4 2.1e-05 24.1 0.1 4.5 4 1 1 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 VDK70972.1 - 8.8e-14 51.1 2.7 0.00013 21.7 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 VDK70972.1 - 4.1e-13 48.2 5.7 0.00034 20.0 0.0 3.4 3 0 0 3 3 3 3 EF hand SPARC_Ca_bdg PF10591.9 VDK70972.1 - 6.8e-05 23.2 1.8 0.023 15.0 0.2 3.2 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 VDK70972.1 - 0.00091 19.2 5.4 2.8 7.9 0.1 3.7 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 VDK70972.1 - 0.014 15.7 0.1 0.72 10.2 0.0 2.7 2 1 1 3 3 3 0 EF-hand domain 2OG-Fe_Oxy_2 PF10014.9 VDK70972.1 - 0.054 13.3 0.1 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 2OG-Fe dioxygenase Caleosin PF05042.13 VDK70972.1 - 0.07 13.1 2.8 15 5.4 0.0 3.2 1 1 1 3 3 3 0 Caleosin related protein S10_plectin PF03501.15 VDK70972.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.6 1 1 0 1 1 1 0 Plectin/S10 domain WD40 PF00400.32 VDK70974.1 - 2.2e-12 47.3 1.2 0.0001 23.0 0.5 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK70974.1 - 2.8e-06 27.6 0.0 0.085 13.2 0.0 3.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Acyl-CoA_dh_1 PF00441.24 VDK70976.1 - 4e-54 182.9 2.1 4.5e-45 153.5 0.9 2.2 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 VDK70976.1 - 7.2e-24 84.6 0.0 1.5e-23 83.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 VDK70976.1 - 1.7e-23 82.6 0.0 3.1e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 VDK70976.1 - 9.7e-19 68.0 0.0 7.7e-17 61.8 0.3 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 VDK70976.1 - 0.0028 17.4 0.1 0.0066 16.1 0.1 1.5 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal RPAP2_Rtr1 PF04181.13 VDK70979.1 - 1.7e-10 41.1 4.8 1.2e-08 35.2 1.7 3.2 2 1 0 2 2 2 1 Rtr1/RPAP2 family Ribosomal_S17_N PF16205.5 VDK70980.1 - 1.9e-34 117.8 0.4 1.9e-34 117.8 0.4 1.6 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 VDK70980.1 - 5.4e-26 90.5 2.7 7.8e-26 90.0 2.7 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 PRF PF06875.11 VDK70980.1 - 0.031 13.7 0.1 0.047 13.1 0.1 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF RasGEF PF00617.19 VDK70981.1 - 2.3e-52 177.8 0.1 4.2e-52 176.9 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 VDK70981.1 - 4.8e-18 65.3 0.1 1.4e-17 63.8 0.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif RA PF00788.23 VDK70981.1 - 2.5e-11 44.1 0.0 6.9e-11 42.6 0.0 1.8 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Pkinase_Tyr PF07714.17 VDK70983.1 - 2.2e-68 230.4 0.0 3.3e-68 229.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK70983.1 - 2.5e-41 141.8 0.0 4.2e-41 141.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 VDK70983.1 - 0.0014 18.1 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SH2 PF00017.24 VDK70983.1 - 0.096 12.8 0.1 0.27 11.3 0.1 1.8 1 0 0 1 1 1 0 SH2 domain NFACT-R_1 PF05670.13 VDK70985.1 - 2.3e-41 140.9 0.0 4e-41 140.1 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain TMEM51 PF15345.6 VDK70985.1 - 0.45 10.3 3.2 0.7 9.7 3.2 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 DUF1764 PF08576.10 VDK70985.1 - 3.4 8.6 10.4 6 7.8 10.4 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF236 PF03057.14 VDK70989.1 - 1.4e-53 178.5 21.0 3.5e-18 65.2 2.6 3.3 3 0 0 3 3 3 3 DUF236 repeat Peptidase_C1 PF00112.23 VDK70990.1 - 2.9e-67 227.0 5.3 7e-67 225.7 5.5 1.5 2 0 0 2 2 2 1 Papain family cysteine protease Propeptide_C1 PF08127.13 VDK70990.1 - 3.2e-06 26.9 0.0 7.3e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 VDK70990.1 - 0.29 9.8 2.6 4.8 5.8 0.4 2.1 2 0 0 2 2 2 0 Peptidase C1-like family Guanylate_kin PF00625.21 VDK70993.1 - 6.9e-63 211.6 0.0 1.2e-62 210.9 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 VDK70993.1 - 5.6e-14 52.3 0.1 1e-13 51.4 0.1 1.5 1 0 0 1 1 1 1 PDZ domain L27 PF02828.16 VDK70993.1 - 1e-07 31.6 0.7 2.9e-07 30.1 0.1 2.1 2 0 0 2 2 2 1 L27 domain SH3_1 PF00018.28 VDK70993.1 - 7.1e-07 28.7 0.5 4e-06 26.3 0.5 2.3 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK70993.1 - 9.3e-07 28.4 0.0 2.3e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PDZ_6 PF17820.1 VDK70993.1 - 0.00017 21.3 0.2 0.00045 20.0 0.2 1.7 1 0 0 1 1 1 1 PDZ domain Polysacc_deac_3 PF15421.6 VDK70993.1 - 0.037 12.6 0.1 0.059 11.9 0.1 1.2 1 0 0 1 1 1 0 Putative polysaccharide deacetylase PDZ_2 PF13180.6 VDK70993.1 - 0.038 14.3 0.1 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 PDZ domain 3-PAP PF12578.8 VDK70993.1 - 0.12 12.1 0.2 0.48 10.2 0.1 2.1 2 0 0 2 2 2 0 Myotubularin-associated protein SH3_9 PF14604.6 VDK70993.1 - 0.12 12.2 0.1 0.32 10.9 0.1 1.7 1 1 0 1 1 1 0 Variant SH3 domain ClpS PF02617.17 VDK70993.1 - 0.78 9.6 0.0 0.78 9.6 0.0 2.8 4 0 0 4 4 4 0 ATP-dependent Clp protease adaptor protein ClpS Pkinase PF00069.25 VDK70994.1 - 1e-58 198.8 0.0 1.3e-58 198.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK70994.1 - 4e-23 82.0 0.0 5.2e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK70994.1 - 1.9e-06 27.4 0.0 3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK70994.1 - 0.00014 20.7 0.0 0.00022 20.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK70994.1 - 0.0069 15.8 0.1 0.013 14.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 VDK70994.1 - 0.011 15.3 0.1 0.025 14.1 0.0 1.5 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 VDK70994.1 - 0.017 14.7 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Helicase_C_2 PF13307.6 VDK70994.1 - 0.05 13.8 0.0 0.086 13.0 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain Collagen PF01391.18 VDK70995.1 - 9e-25 86.2 80.6 1.4e-10 40.8 23.1 3.5 3 0 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK70995.1 - 5.7e-17 61.5 0.2 9.3e-17 60.8 0.2 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain HEAT PF02985.22 VDK71054.1 - 9.5e-08 31.7 2.8 0.0041 17.3 0.1 4.1 5 0 0 5 5 5 2 HEAT repeat HEAT_EZ PF13513.6 VDK71054.1 - 4.3e-07 30.3 1.4 0.01 16.3 0.0 2.9 3 0 0 3 3 3 2 HEAT-like repeat CLASP_N PF12348.8 VDK71054.1 - 5.8e-07 29.3 0.1 1.1e-06 28.4 0.0 1.3 1 1 0 1 1 1 1 CLASP N terminal HEAT_2 PF13646.6 VDK71054.1 - 1e-05 25.8 0.3 0.049 14.0 0.2 2.7 1 1 1 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 VDK71054.1 - 0.00057 20.4 0.2 0.16 12.6 0.1 2.2 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 VDK71054.1 - 0.0048 16.9 0.5 1.5 8.9 0.0 2.9 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 VDK71054.1 - 0.0091 14.6 1.3 0.011 14.3 1.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Tti2 PF10521.9 VDK71054.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.6 1 1 1 2 2 2 0 Tti2 family RasGEF_N_2 PF14663.6 VDK71054.1 - 0.028 14.8 0.7 2.2 8.7 0.0 3.0 3 1 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RIX1 PF08167.12 VDK71054.1 - 0.05 13.3 0.7 0.087 12.6 0.3 1.6 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Cohesin_HEAT PF12765.7 VDK71054.1 - 0.089 13.1 0.1 0.51 10.7 0.0 2.3 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.8 VDK71057.1 - 7.3e-33 114.0 12.2 1.1e-31 110.1 1.8 3.2 3 1 0 3 3 3 2 CLASP N terminal HEAT PF02985.22 VDK71057.1 - 4e-07 29.7 3.7 0.25 11.7 0.0 6.5 7 0 0 7 7 7 2 HEAT repeat HEAT_2 PF13646.6 VDK71057.1 - 8.2e-06 26.1 0.9 0.29 11.6 0.1 3.8 3 1 0 3 3 3 2 HEAT repeats TAN PF11640.8 VDK71057.1 - 1.9e-05 24.9 1.8 0.11 12.7 0.1 2.8 2 0 0 2 2 2 2 Telomere-length maintenance and DNA damage repair HEAT_EZ PF13513.6 VDK71057.1 - 0.0074 16.8 0.3 33 5.1 0.0 4.5 3 1 0 3 3 3 0 HEAT-like repeat RasGEF_N_2 PF14663.6 VDK71057.1 - 0.017 15.5 1.8 0.083 13.3 0.1 3.0 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain DUF1981 PF09324.10 VDK71057.1 - 0.08 12.8 0.2 0.3 11.0 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1981) Vac14_Fab1_bd PF12755.7 VDK71057.1 - 0.66 10.6 3.6 20 5.9 0.3 4.1 3 2 0 3 3 3 0 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 VDK71057.1 - 0.75 9.7 9.5 1.7 8.5 0.2 4.2 3 2 1 4 4 4 0 Domain of unknown function (DUF3385) RRF_GI PF12614.8 VDK71059.1 - 0.063 13.4 0.2 0.072 13.2 0.2 1.0 1 0 0 1 1 1 0 Ribosome recycling factor Pkinase_Tyr PF07714.17 VDK71061.1 - 1.1e-78 264.1 0.7 1.6e-78 263.6 0.7 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK71061.1 - 4.4e-41 141.0 0.9 7.2e-41 140.3 0.9 1.3 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK71061.1 - 1.3e-06 28.4 0.4 3.1e-06 27.2 0.0 1.9 2 0 0 2 2 2 1 SH2 domain APH PF01636.23 VDK71061.1 - 0.051 13.5 0.0 0.38 10.6 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Ctr PF04145.15 VDK71061.1 - 1.2 9.8 3.7 1.6 9.4 0.0 2.4 2 0 0 2 2 2 0 Ctr copper transporter family KH_1 PF00013.29 VDK71063.1 - 4e-52 173.9 12.6 1.5e-14 53.5 0.2 5.7 5 1 0 5 5 5 5 KH domain KH_2 PF07650.17 VDK71063.1 - 3.1e-13 49.3 11.6 0.0062 16.3 0.8 4.5 4 0 0 4 4 4 4 KH domain KH_4 PF13083.6 VDK71063.1 - 1.4e-08 34.5 4.5 0.018 14.9 0.3 4.4 4 0 0 4 4 4 2 KH domain KH_5 PF13184.6 VDK71063.1 - 4.1e-07 30.0 8.4 0.64 10.1 0.2 4.5 4 0 0 4 4 4 4 NusA-like KH domain MOEP19 PF16005.5 VDK71063.1 - 0.031 14.3 0.0 1.8 8.6 0.0 2.9 3 0 0 3 3 3 0 KH-like RNA-binding domain Ion_trans PF00520.31 VDK71064.1 - 9.5e-109 362.3 98.4 1.5e-31 109.5 19.4 4.1 4 0 0 4 4 4 4 Ion transport protein PsaF PF17550.2 VDK71064.1 - 0.052 13.1 0.7 0.17 11.4 0.7 1.9 1 0 0 1 1 1 0 Family of unknown function PKD_channel PF08016.12 VDK71064.1 - 1.8 7.1 75.8 0.013 14.2 10.4 6.7 7 1 0 7 7 7 0 Polycystin cation channel RRXRR PF14239.6 VDK71065.1 - 0.0076 16.1 0.0 0.0079 16.1 0.0 1.2 1 0 0 1 1 1 1 RRXRR protein DUF460 PF04312.13 VDK71065.1 - 0.061 13.0 0.0 0.08 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF460) Ribosomal_S9 PF00380.19 VDK71066.1 - 9.4e-19 68.1 0.0 1.9e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 MEIOC PF15189.6 VDK71067.1 - 1.2e-65 220.2 4.0 1.9e-65 219.5 4.0 1.3 1 0 0 1 1 1 1 Meiosis-specific coiled-coil domain-containing protein MEIOC CAMSAP_CC1 PF17095.5 VDK71067.1 - 0.0064 16.3 1.8 0.014 15.2 1.8 1.5 1 0 0 1 1 1 1 Spectrin-binding region of Ca2+-Calmodulin Fip1 PF05182.13 VDK71068.1 - 1.7e-23 81.9 0.9 2.8e-23 81.2 0.9 1.4 1 0 0 1 1 1 1 Fip1 motif EAP30 PF04157.16 VDK71069.1 - 3.3e-38 131.3 0.4 4.3e-38 130.9 0.4 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 VDK71069.1 - 2.4e-19 69.3 0.0 4.3e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 PITH PF06201.13 VDK71070.1 - 1.4e-38 132.5 0.0 1.9e-38 132.1 0.0 1.2 1 0 0 1 1 1 1 PITH domain Cyclin_N PF00134.23 VDK71071.1 - 3.8e-13 49.3 0.3 6.8e-13 48.5 0.3 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 VDK71071.1 - 4.9e-07 30.2 0.1 6.9e-07 29.8 0.1 1.3 1 0 0 1 1 1 1 Cyclin CH PF00307.31 VDK71073.1 - 3e-15 56.3 0.1 1.1e-14 54.5 0.0 2.1 2 1 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK71073.1 - 0.00062 19.5 0.0 0.0032 17.3 0.0 2.1 2 0 0 2 2 2 1 CAMSAP CH domain DUF3858 PF12970.7 VDK71073.1 - 0.024 14.6 0.4 2.1 8.4 0.1 2.6 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3858) ATG16 PF08614.11 VDK71073.1 - 3.6 7.8 29.1 0.51 10.5 21.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Pkinase PF00069.25 VDK71075.1 - 4.2e-36 124.7 0.0 6.3e-36 124.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK71075.1 - 1.3e-35 122.9 0.0 1.9e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TGF_beta_GS PF08515.12 VDK71075.1 - 3.4e-12 45.6 1.8 6e-12 44.8 0.1 2.3 2 0 0 2 2 2 1 Transforming growth factor beta type I GS-motif Vps8 PF12816.7 VDK71076.1 - 2.9e-41 141.2 0.2 6e-41 140.1 0.2 1.6 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 ANAPC4_WD40 PF12894.7 VDK71076.1 - 0.00032 20.9 0.0 0.0017 18.6 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4158 PF13700.6 VDK71076.1 - 0.038 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) Prok-RING_4 PF14447.6 VDK71077.1 - 0.13 12.1 9.0 0.26 11.2 9.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 VDK71077.1 - 0.21 11.5 8.4 0.61 10.1 8.4 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3H2C3 PF17122.5 VDK71077.1 - 2.1 8.5 7.8 5.2 7.2 7.8 1.7 1 0 0 1 1 1 0 Zinc-finger MIT_C PF16565.5 VDK71079.1 - 2.3e-43 147.6 0.0 3.5e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 Phospholipase D-like domain at C-terminus of MIT CLCA PF08434.11 VDK71079.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel N terminal LAMTOR5 PF16672.5 VDK71081.1 - 9.1e-25 86.4 0.3 1e-24 86.2 0.3 1.0 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 RRM_1 PF00076.22 VDK71083.1 - 6.9e-32 109.1 0.0 1.6e-15 56.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4497 PF14924.6 VDK71083.1 - 0.082 13.4 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) 7tm_2 PF00002.24 VDK71119.1 - 7.2e-53 179.4 10.6 1e-52 178.9 10.6 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) HRM PF02793.22 VDK71119.1 - 2.6e-10 40.4 5.7 5e-10 39.5 5.7 1.5 1 0 0 1 1 1 1 Hormone receptor domain TTL PF03133.15 VDK71121.1 - 8.6e-88 294.3 0.4 1.3e-87 293.7 0.4 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 VDK71121.1 - 4.7e-06 26.0 0.0 0.0033 16.7 0.0 3.0 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 VDK71121.1 - 1.2e-05 24.7 0.0 0.014 14.7 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 VDK71121.1 - 0.062 12.8 0.0 5.1 6.6 0.0 2.9 3 0 0 3 3 3 0 D-ala D-ala ligase C-terminus Methyltransf_3 PF01596.17 VDK71121.1 - 0.08 12.1 0.1 0.13 11.4 0.1 1.3 1 0 0 1 1 1 0 O-methyltransferase Ipi1_N PF12333.8 VDK71124.1 - 8.8e-08 32.7 5.3 3.4e-06 27.6 0.5 3.3 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation MMS19_C PF12460.8 VDK71124.1 - 0.038 13.1 7.3 0.047 12.8 2.7 2.6 2 1 1 3 3 3 0 RNAPII transcription regulator C-terminal Adaptin_N PF01602.20 VDK71124.1 - 0.048 12.2 2.4 0.19 10.2 2.4 2.2 1 1 0 1 1 1 0 Adaptin N terminal region Urb2 PF10441.9 VDK71124.1 - 0.19 11.7 3.0 0.22 11.4 1.5 2.0 2 0 0 2 2 2 0 Urb2/Npa2 family HMG_box PF00505.19 VDK71125.1 - 9.9e-12 45.1 5.5 2.1e-11 44.1 3.3 2.8 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK71125.1 - 6.9e-07 29.8 2.2 6.9e-07 29.8 2.2 2.4 2 1 1 3 3 3 1 HMG-box domain Protamine_like PF06382.11 VDK71125.1 - 0.2 11.8 3.9 0.49 10.6 3.8 1.7 1 1 0 1 1 1 0 Protamine and protamine like ArAE_2_N PF10337.9 VDK71125.1 - 0.46 9.5 3.6 0.75 8.8 3.6 1.4 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal PBP_dimer PF03717.15 VDK71125.1 - 1.4 9.2 7.8 0.53 10.6 0.6 2.4 2 1 0 2 2 2 0 Penicillin-binding Protein dimerisation domain SlyX PF04102.12 VDK71125.1 - 4.6 7.9 8.3 0.45 11.2 0.4 2.8 3 0 0 3 3 3 0 SlyX ZapB PF06005.12 VDK71125.1 - 6.1 7.4 11.7 0.27 11.7 1.3 2.6 2 0 0 2 2 2 0 Cell division protein ZapB FH2 PF02181.23 VDK71126.1 - 1.7e-69 234.7 10.1 1.7e-69 234.7 10.1 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 VDK71126.1 - 1.4e-33 116.2 0.0 1.4e-33 116.2 0.0 3.5 4 1 0 4 4 4 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 VDK71126.1 - 3.5e-19 69.1 4.0 3.5e-19 69.1 4.0 2.7 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain NblA PF04485.12 VDK71126.1 - 0.053 13.9 0.1 0.27 11.7 0.0 2.2 2 0 0 2 2 2 0 Phycobilisome degradation protein nblA SNARE PF05739.19 VDK71127.1 - 1.2e-05 25.2 0.9 3e-05 23.9 0.2 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 VDK71127.1 - 0.00073 19.3 10.4 0.0033 17.1 0.7 2.3 2 0 0 2 2 2 2 Syntaxin Hexose_dehydrat PF03559.14 VDK71127.1 - 0.072 12.5 0.6 0.15 11.4 0.6 1.5 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase Collagen PF01391.18 VDK71129.1 - 1.7e-25 88.5 109.5 1e-09 38.0 38.2 4.1 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK71129.1 - 6e-21 74.2 0.4 8.2e-21 73.8 0.4 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain COX14 PF14880.6 VDK71129.1 - 0.03 14.2 0.4 0.049 13.5 0.4 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly NEMP PF10225.9 VDK71132.1 - 3.1e-77 259.6 11.6 4.7e-77 259.0 11.6 1.3 1 0 0 1 1 1 1 NEMP family Mor PF08765.11 VDK71132.1 - 0.17 11.9 0.4 1.2 9.1 0.2 2.2 2 0 0 2 2 2 0 Mor transcription activator family REPA_OB_2 PF16900.5 VDK71135.1 - 2.7e-23 81.7 0.9 8.7e-20 70.5 0.1 2.9 3 0 0 3 3 3 2 Replication protein A OB domain Rep_fac-A_C PF08646.10 VDK71135.1 - 2.1e-16 60.0 6.1 5.8e-09 35.8 1.3 3.9 2 1 2 4 4 4 2 Replication factor-A C terminal domain tRNA_anti-codon PF01336.25 VDK71135.1 - 6.1e-15 55.0 2.6 1.3e-09 37.9 0.2 3.6 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain Rep-A_N PF04057.12 VDK71135.1 - 1.2e-07 31.6 0.0 3.7e-07 30.1 0.0 1.9 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain DUF223 PF02721.14 VDK71135.1 - 0.0063 16.8 0.0 0.025 14.9 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function DUF223 SSB PF00436.25 VDK71135.1 - 0.019 15.0 0.2 0.27 11.3 0.0 2.8 2 1 0 2 2 2 0 Single-strand binding protein family bZIP_2 PF07716.15 VDK71136.1 - 1.1e-11 44.6 15.1 2e-11 43.8 15.1 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 VDK71136.1 - 6.5e-06 26.2 13.4 9.1e-06 25.7 13.4 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 VDK71136.1 - 0.00044 20.7 11.8 0.00055 20.4 11.8 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor RasGAP_C PF03836.15 VDK71136.1 - 0.0035 17.5 2.9 0.0044 17.2 2.9 1.2 1 0 0 1 1 1 1 RasGAP C-terminus GIT_CC PF16559.5 VDK71136.1 - 0.028 14.3 1.2 0.048 13.5 1.2 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor APG6_N PF17675.1 VDK71136.1 - 0.039 14.5 7.6 0.049 14.2 7.6 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region Ax_dynein_light PF10211.9 VDK71136.1 - 0.051 13.5 6.0 0.056 13.4 6.0 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain UPF0242 PF06785.11 VDK71136.1 - 0.15 12.1 8.3 0.18 11.9 8.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Lipoprotein_20 PF13942.6 VDK71136.1 - 0.23 11.4 7.9 0.28 11.1 7.9 1.1 1 0 0 1 1 1 0 YfhG lipoprotein DUF5320 PF17253.2 VDK71136.1 - 0.37 11.9 2.7 0.65 11.1 2.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5320) CCDC-167 PF15188.6 VDK71136.1 - 0.4 11.0 5.8 0.56 10.6 5.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF4407 PF14362.6 VDK71136.1 - 0.43 9.9 5.9 0.51 9.6 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pheromone PF08015.11 VDK71137.1 - 0.15 13.1 1.3 0.25 12.4 1.1 1.5 1 1 0 1 1 1 0 Fungal mating-type pheromone RAI16-like PF10257.9 VDK71138.1 - 1.5e-53 182.0 6.3 2.2e-53 181.4 6.3 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein DUF2451 PF10474.9 VDK71144.1 - 1.4e-76 257.4 1.2 1.4e-76 257.4 1.2 2.5 2 1 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 VDK71144.1 - 3.8e-68 229.9 13.9 9.3e-68 228.6 13.9 1.7 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex MnmE_helical PF12631.7 VDK71144.1 - 0.97 9.6 3.3 2.5 8.2 2.5 2.0 1 1 0 1 1 1 0 MnmE helical domain Alba PF01918.21 VDK71148.1 - 2.4e-14 52.9 0.4 4e-14 52.2 0.4 1.4 1 0 0 1 1 1 1 Alba NTP_transf_5 PF14907.6 VDK71148.1 - 0.068 12.8 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase PDZ_6 PF17820.1 VDK71149.1 - 8.8e-08 31.9 0.0 1.3e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDK71149.1 - 3.8e-05 24.0 0.0 4.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK71149.1 - 0.0012 19.1 0.0 0.0017 18.6 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PAX PF00292.18 VDK71176.1 - 1.5e-62 209.1 2.0 4.9e-62 207.4 0.2 2.0 1 1 0 2 2 2 1 'Paired box' domain HTH_23 PF13384.6 VDK71176.1 - 6.1e-05 22.7 0.0 0.00013 21.7 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 VDK71176.1 - 0.0016 18.0 0.0 0.0065 16.1 0.0 1.9 2 0 0 2 2 2 1 InsA C-terminal domain HTH_32 PF13565.6 VDK71176.1 - 0.0081 16.7 0.2 2.2 8.9 0.2 2.8 2 1 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 VDK71176.1 - 0.055 13.2 0.0 0.36 10.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.6 VDK71176.1 - 0.089 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Homeodomain PF00046.29 VDK71178.1 - 1.4e-23 82.5 4.1 2.3e-23 81.8 4.1 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK71178.1 - 0.023 14.6 0.8 0.059 13.3 0.1 2.0 2 0 0 2 2 2 0 Homeobox KN domain G-gamma PF00631.22 VDK71179.1 - 5e-14 52.1 0.1 8.2e-14 51.4 0.1 1.3 1 0 0 1 1 1 1 GGL domain Endonuc-FokI_C PF09254.11 VDK71179.1 - 0.013 14.8 0.2 0.25 10.6 0.1 2.1 1 1 1 2 2 2 0 Restriction endonuclease FokI, C terminal TrwB_AAD_bind PF10412.9 VDK71179.1 - 0.081 11.8 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain PHR PF08005.12 VDK71181.1 - 3.9e-48 163.9 0.1 6e-48 163.4 0.1 1.3 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 VDK71181.1 - 2.5e-22 79.2 0.0 7.2e-21 74.5 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 VDK71181.1 - 2.9e-08 33.7 0.2 1e-07 32.0 0.1 2.0 2 1 0 2 2 2 1 BTB And C-terminal Kelch DUF4082 PF13313.6 VDK71181.1 - 0.015 15.4 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) AhpC-TSA PF00578.21 VDK71182.1 - 3.1e-37 127.3 0.0 4.8e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK71182.1 - 1.2e-12 47.8 0.0 1.6e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 VDK71182.1 - 5.4e-10 38.9 0.1 9e-10 38.2 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Filament_head PF04732.14 VDK71182.1 - 0.1 13.5 0.7 0.17 12.8 0.7 1.4 1 0 0 1 1 1 0 Intermediate filament head (DNA binding) region IMS PF00817.20 VDK71183.1 - 1.1e-41 142.3 0.2 2.2e-41 141.3 0.2 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 VDK71183.1 - 4.1e-11 43.6 0.0 1.1e-10 42.2 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 VDK71183.1 - 1.4e-07 31.4 0.1 4e-07 30.0 0.1 1.8 1 0 0 1 1 1 1 IMS family HHH motif PRK PF00485.18 VDK71183.1 - 0.38 10.5 1.8 4 7.1 0.0 2.5 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family RRM_1 PF00076.22 VDK71185.1 - 4.7e-23 80.8 0.0 6.4e-23 80.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 VDK71185.1 - 0.0007 19.9 0.0 0.19 11.9 0.0 2.2 1 1 1 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 VDK71185.1 - 0.055 13.6 0.0 0.11 12.6 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 VDK71185.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif MTBP_N PF14918.6 VDK71185.1 - 0.16 11.4 0.0 0.2 11.1 0.0 1.1 1 0 0 1 1 1 0 MDM2-binding HSCB_C PF07743.13 VDK71187.1 - 1.4e-10 41.5 3.1 4.1e-09 36.8 0.4 2.2 2 0 0 2 2 2 2 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 VDK71187.1 - 1.5e-05 25.0 0.1 2.9e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 VDK71189.1 - 9.8e-28 95.8 0.3 4.2e-14 52.1 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK71189.1 - 2.5e-07 30.3 0.0 0.031 13.9 0.0 2.5 1 1 2 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK71189.1 - 0.00038 20.3 0.0 0.42 10.5 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif DUF4523 PF15023.6 VDK71189.1 - 0.0042 16.9 0.0 0.0092 15.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) zf-C2H2_4 PF13894.6 VDK71190.1 - 7.7e-06 26.3 37.6 0.47 11.4 0.2 6.6 6 0 0 6 6 6 4 C2H2-type zinc finger zf-BED PF02892.15 VDK71190.1 - 0.056 13.5 0.3 0.056 13.5 0.3 4.1 5 0 0 5 5 5 0 BED zinc finger zf_C2H2_ZHX PF18387.1 VDK71190.1 - 0.082 12.6 9.0 0.77 9.4 1.0 3.8 3 1 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 VDK71190.1 - 0.98 10.1 20.7 4.5 8.0 3.5 5.2 3 2 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats PHM7_cyt PF14703.6 VDK71190.1 - 3.5 7.8 12.0 0.88 9.8 0.4 2.7 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter zf-H2C2_2 PF13465.6 VDK71190.1 - 4.4 7.9 17.4 4.8 7.8 0.5 5.7 5 0 0 5 5 5 0 Zinc-finger double domain zf-C2H2 PF00096.26 VDK71190.1 - 7.1 7.3 34.4 0.29 11.7 1.6 5.8 6 0 0 6 6 6 0 Zinc finger, C2H2 type Ada3 PF10198.9 VDK71191.1 - 0.0067 16.6 0.4 0.018 15.2 0.4 1.7 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 PTH2 PF01981.16 VDK71195.1 - 5.8e-22 78.2 0.1 7.5e-22 77.8 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 PfkB PF00294.24 VDK71195.1 - 0.0075 15.6 0.0 0.0084 15.4 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Met_10 PF02475.16 VDK71195.1 - 0.033 13.9 0.0 0.039 13.7 0.0 1.1 1 0 0 1 1 1 0 Met-10+ like-protein ARTD15_N PF18084.1 VDK71195.1 - 0.11 12.8 0.1 0.28 11.5 0.1 1.7 1 1 0 1 1 1 0 ARTD15 N-terminal domain Latarcin PF10279.9 VDK71195.1 - 0.14 12.6 0.2 0.58 10.6 0.2 2.0 1 1 0 1 1 1 0 Latarcin precursor LMWPc PF01451.21 VDK71196.1 - 4.7e-16 59.5 0.0 5.1e-16 59.3 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase THB PF18362.1 VDK71196.1 - 0.077 12.6 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Tri-helix bundle domain LIM PF00412.22 VDK71198.1 - 1.3e-22 79.7 15.4 8.8e-13 48.3 2.0 3.7 3 1 0 3 3 3 3 LIM domain VHP PF02209.19 VDK71198.1 - 2.1e-13 50.1 1.3 5e-13 48.9 1.3 1.7 1 0 0 1 1 1 1 Villin headpiece domain AbLIM_anchor PF16182.5 VDK71198.1 - 0.0019 18.1 4.9 0.0035 17.2 4.9 1.5 1 1 0 1 1 1 1 Putative adherens-junction anchoring region of AbLIM TNFR_c6 PF00020.18 VDK71198.1 - 1.9 9.0 12.6 2.5 8.6 1.0 3.5 4 0 0 4 4 4 0 TNFR/NGFR cysteine-rich region C1_1 PF00130.22 VDK71198.1 - 4.4 7.3 9.8 5.3 7.0 1.3 3.0 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ER_lumen_recept PF00810.18 VDK71199.1 - 1.3e-31 110.4 8.1 1.3e-31 110.4 8.1 3.0 2 1 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 VDK71199.1 - 0.00091 18.9 4.3 0.5 10.2 0.3 3.1 2 0 0 2 2 2 2 PQ loop repeat zf_CCCH_5 PF18384.1 VDK71201.1 - 1.6e-18 66.5 16.1 1.6e-18 66.5 16.1 3.0 2 1 0 2 2 2 1 Unkempt Zinc finger domain 1 (Znf1) zf-CCCH PF00642.24 VDK71201.1 - 0.0022 17.8 0.2 0.0022 17.8 0.2 6.4 6 1 0 6 6 6 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK71201.1 - 0.067 13.3 0.0 0.067 13.3 0.0 5.5 5 0 0 5 5 5 0 Zinc finger domain DUF3584 PF12128.8 VDK71201.1 - 0.084 10.4 4.1 0.12 9.9 4.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) PGAP1 PF07819.13 VDK71202.1 - 1.2e-58 198.6 0.0 1.8e-58 198.0 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 VDK71202.1 - 0.00045 19.6 0.0 0.16 11.3 0.0 2.2 1 1 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 VDK71202.1 - 0.0013 19.4 0.0 0.0022 18.7 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 VDK71202.1 - 0.003 17.5 0.0 0.0045 16.9 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase LIDHydrolase PF10230.9 VDK71202.1 - 0.0052 16.4 0.1 0.022 14.3 0.1 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DUF676 PF05057.14 VDK71202.1 - 0.0068 15.9 0.1 0.014 15.0 0.1 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 VDK71202.1 - 0.014 15.0 0.4 0.078 12.6 0.2 2.3 2 1 0 2 2 2 0 alpha/beta hydrolase fold LCAT PF02450.15 VDK71202.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase TAF4 PF05236.14 VDK71203.1 - 3.1e-28 99.3 10.0 3.1e-28 99.3 10.0 2.8 2 1 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family TAFH PF07531.14 VDK71203.1 - 3.1e-23 81.7 0.4 7.2e-23 80.5 0.4 1.6 1 0 0 1 1 1 1 NHR1 homology to TAF P63C PF10546.9 VDK71203.1 - 0.088 13.4 0.0 0.27 11.8 0.0 1.8 1 0 0 1 1 1 0 P63C domain TipAS PF07739.13 VDK71203.1 - 0.13 12.8 0.3 0.13 12.8 0.3 2.2 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain DUF5383 PF17355.2 VDK71203.1 - 0.13 12.6 0.8 0.44 10.9 0.8 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5383) CDT1_C PF16679.5 VDK71203.1 - 5.9 7.4 7.8 0.37 11.3 1.1 2.5 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain PCM1_C PF15717.5 VDK71230.1 - 6.5e-16 58.2 0.9 8.5e-16 57.8 0.9 1.2 1 0 0 1 1 1 1 Pericentriolar material 1 C terminus LIM PF00412.22 VDK71234.1 - 1.4e-13 50.8 24.8 1.1e-10 41.6 15.9 2.2 2 0 0 2 2 2 2 LIM domain Cytochrome_CBB3 PF13442.6 VDK71234.1 - 0.015 15.6 8.2 0.9 9.9 0.2 3.0 3 0 0 3 3 3 0 Cytochrome C oxidase, cbb3-type, subunit III B277 PF17623.2 VDK71234.1 - 0.029 13.4 0.1 0.042 12.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function Anti-TRAP PF15777.5 VDK71234.1 - 1.4 8.9 16.3 5.8 7.0 0.1 3.3 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein MCR PF18509.1 VDK71234.1 - 1.6 8.4 6.0 2.2 7.9 0.3 2.7 2 0 0 2 2 2 0 Magnetochrome domain PSCyt3 PF07627.11 VDK71234.1 - 5.9 7.2 9.5 5.1 7.4 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1588) TTR-52 PF01060.23 VDK71235.1 - 2e-20 73.3 0.0 2.5e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family TTR-52 PF01060.23 VDK71237.1 - 4.5e-36 123.4 0.3 3.4e-22 78.9 0.0 2.2 2 0 0 2 2 2 2 Transthyretin-like family DUF2080 PF09853.9 VDK71237.1 - 0.05 13.3 0.2 2.4 7.9 0.0 2.7 2 0 0 2 2 2 0 Putative transposon-encoded protein (DUF2080) TTR-52 PF01060.23 VDK71238.1 - 5.8e-21 75.0 0.0 7.9e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family Cpn60_TCP1 PF00118.24 VDK71239.1 - 1.5e-86 291.0 16.2 2.3e-86 290.4 16.2 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NAD_binding_8 PF13450.6 VDK71239.1 - 1.2e-08 35.0 0.6 4.1e-08 33.3 0.6 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 VDK71239.1 - 3.2e-07 29.8 1.3 4.5e-06 26.0 0.9 2.4 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 VDK71239.1 - 1.1e-06 28.6 2.3 3.4e-05 23.6 2.2 2.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 VDK71239.1 - 1.3e-05 24.7 2.4 6.4e-05 22.4 0.7 2.7 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 VDK71239.1 - 4.2e-05 23.0 0.7 8.2e-05 22.0 0.7 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 VDK71239.1 - 4.6e-05 22.8 2.6 8.3e-05 21.9 0.0 2.5 3 0 0 3 3 3 1 Thi4 family FAD_oxidored PF12831.7 VDK71239.1 - 0.00036 20.0 0.4 0.00062 19.2 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 VDK71239.1 - 0.0011 17.8 0.2 0.0024 16.6 0.2 1.6 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 VDK71239.1 - 0.0023 17.2 0.0 0.0076 15.5 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 VDK71239.1 - 0.0031 16.1 0.1 0.027 13.0 0.0 2.1 2 0 0 2 2 2 1 GDP dissociation inhibitor Pyr_redox PF00070.27 VDK71239.1 - 0.0075 16.8 0.2 0.0075 16.8 0.2 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 VDK71239.1 - 0.16 11.0 0.1 0.25 10.4 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Cpn10 PF00166.21 VDK71240.1 - 9.7e-32 108.9 0.0 1.1e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit 4HBT PF03061.22 VDK71243.1 - 1.9e-15 57.0 0.1 3.6e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 VDK71243.1 - 2.5e-06 27.9 0.0 3.4e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT_2 PF13279.6 VDK71243.1 - 0.0077 16.7 0.0 0.011 16.2 0.0 1.3 1 1 0 1 1 1 1 Thioesterase-like superfamily DUF334 PF03904.13 VDK71243.1 - 0.095 12.2 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Cluap1 PF10234.9 VDK71244.1 - 2.9e-60 203.9 9.4 2.9e-60 203.9 9.4 1.4 2 0 0 2 2 2 1 Clusterin-associated protein-1 PCEMA1 PF07418.11 VDK71244.1 - 6.6 6.2 14.7 1 8.9 10.6 1.7 1 1 1 2 2 2 0 Acidic phosphoprotein precursor PCEMA1 Y_phosphatase PF00102.27 VDK71245.1 - 1.1e-31 110.3 0.2 1.7e-31 109.6 0.2 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase RNA_pol_L PF01193.24 VDK71245.1 - 0.031 13.7 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain GTP_EFTU PF00009.27 VDK71250.1 - 5.7e-53 179.3 0.0 8.6e-53 178.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 VDK71250.1 - 1.3e-16 60.7 2.3 2e-16 60.1 1.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 VDK71250.1 - 8.5e-09 35.7 0.0 2.4e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 VDK71250.1 - 0.00032 20.7 0.0 0.00054 20.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DDRGK PF09756.9 VDK71251.1 - 3.1e-56 190.0 31.1 3.1e-56 190.0 31.1 1.5 2 0 0 2 2 2 1 DDRGK domain FeoC PF09012.10 VDK71251.1 - 0.0031 17.5 0.0 0.4 10.8 0.0 2.5 2 0 0 2 2 2 1 FeoC like transcriptional regulator SLC12 PF03522.15 VDK71251.1 - 0.14 11.2 7.8 0.19 10.7 7.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DDHD PF02862.17 VDK71251.1 - 0.31 11.2 2.3 0.4 10.8 2.3 1.3 1 0 0 1 1 1 0 DDHD domain Caldesmon PF02029.15 VDK71251.1 - 0.6 8.8 38.0 0.88 8.3 38.0 1.2 1 0 0 1 1 1 0 Caldesmon RR_TM4-6 PF06459.12 VDK71251.1 - 0.95 9.2 17.4 1.2 8.9 17.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 VDK71251.1 - 1.4 6.8 7.7 1.5 6.7 7.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Asp-B-Hydro_N PF05279.11 VDK71251.1 - 2.1 8.3 27.9 3.6 7.6 27.9 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region GAGA_bind PF06217.12 VDK71251.1 - 3 8.1 9.8 5.2 7.3 9.8 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family Presenilin PF01080.17 VDK71251.1 - 6.8 5.3 13.6 9.6 4.8 13.6 1.3 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 VDK71251.1 - 9.8 6.5 21.7 18 5.6 21.7 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RRM_1 PF00076.22 VDK71252.1 - 2.9e-19 68.7 0.0 4.2e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AF-4 PF05110.13 VDK71252.1 - 0.082 11.0 33.8 0.11 10.6 33.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RRM_3 PF08777.11 VDK71252.1 - 0.087 12.9 0.1 0.31 11.1 0.0 1.9 2 1 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.5 VDK71252.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.5 1 1 0 1 1 1 0 Occluded RNA-recognition motif Ndc1_Nup PF09531.10 VDK71252.1 - 2 7.0 15.0 2.7 6.6 15.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SSP160 PF06933.11 VDK71252.1 - 8.5 4.4 13.2 10 4.2 13.2 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 LRR_8 PF13855.6 VDK71255.1 - 1.8e-17 62.8 6.2 0.0002 21.1 0.0 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_5 PF13306.6 VDK71255.1 - 1.7e-13 50.6 2.3 3.3e-08 33.5 1.3 2.5 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 VDK71255.1 - 0.007 15.9 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 Leucine-rich repeat Tim17 PF02466.19 VDK71255.1 - 0.02 15.3 0.1 0.027 14.9 0.1 1.4 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family TTR-52 PF01060.23 VDK71256.1 - 5.1e-25 88.0 0.0 5.9e-25 87.8 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family Acetyltransf_1 PF00583.25 VDK71258.1 - 2.3e-14 53.7 0.0 3e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 VDK71258.1 - 3.3e-07 30.6 0.0 4.8e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 VDK71258.1 - 5.5e-06 26.3 0.0 7.9e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 VDK71258.1 - 0.02 14.9 0.0 0.051 13.7 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain CAP_N PF01213.19 VDK71258.1 - 0.069 12.6 2.1 0.09 12.3 2.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 VDK71258.1 - 0.093 12.8 4.6 0.18 11.9 4.6 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 VDK71258.1 - 0.74 9.9 2.7 1.1 9.3 2.7 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Lig_chan PF00060.26 VDK71259.1 - 9.3e-56 187.8 0.5 1.6e-55 187.1 0.5 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 VDK71259.1 - 2.8e-38 130.7 0.0 7.1e-38 129.3 0.0 1.7 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site SBP_bac_3 PF00497.20 VDK71259.1 - 5.4e-26 91.4 0.0 1.5e-25 90.0 0.0 1.7 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Collagen PF01391.18 VDK71260.1 - 2.6e-24 84.7 100.6 0.0073 16.0 14.3 4.1 2 1 0 2 2 2 1 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK71260.1 - 2e-16 59.8 2.3 2.8e-16 59.3 2.3 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Collagen PF01391.18 VDK71262.1 - 1.9e-24 85.2 93.7 0.00026 20.7 10.6 4.2 2 1 0 2 2 2 1 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK71262.1 - 7.4e-11 41.9 1.9 1e-10 41.5 1.9 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Peptidase_M3 PF01432.20 VDK71265.1 - 3.4e-86 290.3 0.8 5.3e-86 289.7 0.8 1.3 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M32 PF02074.15 VDK71265.1 - 0.047 12.5 2.3 0.048 12.4 0.3 1.9 2 0 0 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase MitMem_reg PF13012.6 VDK71266.1 - 9e-23 80.8 0.4 1.5e-22 80.1 0.4 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 VDK71266.1 - 9.2e-16 57.9 0.5 1.8e-15 56.9 0.5 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Gln-synt_C PF00120.24 VDK71267.1 - 9.5e-20 70.9 0.0 2.3e-19 69.6 0.0 1.5 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 VDK71267.1 - 8.1e-13 47.9 0.0 1.4e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Collagen PF01391.18 VDK71268.1 - 2e-24 85.1 73.8 9.9e-10 38.0 21.1 4.0 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK71268.1 - 1.1e-11 44.6 0.6 1.5e-11 44.2 0.6 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Ldl_recept_a PF00057.18 VDK71311.1 - 4.8e-18 65.1 61.0 5.2e-09 36.2 7.7 4.4 5 0 0 5 5 5 3 Low-density lipoprotein receptor domain class A I-set PF07679.16 VDK71311.1 - 1.1e-07 31.8 0.0 2.4e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK71311.1 - 3.6e-05 24.3 0.0 8.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain SEA PF01390.20 VDK71311.1 - 0.0097 16.0 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 1 SEA domain Flagellin_D3 PF08884.11 VDK71311.1 - 0.1 13.0 0.2 0.21 12.0 0.2 1.4 1 0 0 1 1 1 0 Flagellin D3 domain MBOAT PF03062.19 VDK71314.1 - 3.5e-10 39.8 26.3 9.8e-10 38.3 25.9 2.0 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Gate PF07670.14 VDK71314.1 - 5.7 7.2 6.4 23 5.3 6.4 2.2 1 1 0 1 1 1 0 Nucleoside recognition Ldl_recept_a PF00057.18 VDK71316.1 - 1.1e-36 124.7 66.5 1.1e-09 38.3 10.7 4.4 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A ig PF00047.25 VDK71320.1 - 0.02 15.0 0.0 0.045 13.9 0.0 1.6 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 VDK71320.1 - 0.027 14.5 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin I-set domain Ig_2 PF13895.6 VDK71320.1 - 0.056 13.8 0.0 0.083 13.2 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Laminin_G_2 PF02210.24 VDK71324.1 - 1.8e-57 193.3 0.0 8.4e-26 91.0 0.0 3.6 4 0 0 4 4 3 3 Laminin G domain Laminin_G_1 PF00054.23 VDK71324.1 - 2e-52 176.9 0.0 1.4e-23 83.6 0.0 3.3 3 0 0 3 3 3 3 Laminin G domain Laminin_G_3 PF13385.6 VDK71324.1 - 4.1e-09 36.8 0.2 0.017 15.3 0.2 3.3 3 0 0 3 3 3 3 Concanavalin A-like lectin/glucanases superfamily Ig_3 PF13927.6 VDK71324.1 - 1.2e-06 29.1 0.0 4.9e-06 27.1 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 VDK71324.1 - 2.7e-05 24.4 0.0 9.1e-05 22.7 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 VDK71324.1 - 0.00011 22.2 0.0 0.00031 20.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain V-set PF07686.17 VDK71324.1 - 0.0013 18.9 0.3 0.21 11.8 0.1 3.6 3 1 1 4 4 4 1 Immunoglobulin V-set domain ig PF00047.25 VDK71324.1 - 0.0077 16.4 0.0 0.024 14.8 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 VDK71324.1 - 0.061 13.9 0.0 0.22 12.1 0.0 1.9 1 0 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain Spo0M PF07070.11 VDK71324.1 - 0.31 10.6 2.3 0.35 10.4 0.1 2.2 3 0 0 3 3 3 0 SpoOM protein Cyt_bd_oxida_II PF02322.15 VDK71324.1 - 0.51 9.7 2.5 0.72 9.2 2.5 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II Ldl_recept_a PF00057.18 VDK71327.1 - 2.6e-66 219.5 159.4 2e-12 47.1 10.5 10.0 11 0 0 11 11 11 7 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 VDK71327.1 - 4.9e-38 129.4 7.3 6.5e-12 45.7 0.1 6.5 6 0 0 6 6 6 5 Low-density lipoprotein receptor repeat class B cEGF PF12662.7 VDK71327.1 - 2.7e-07 30.4 24.6 1.1e-05 25.2 1.5 5.5 4 0 0 4 4 4 3 Complement Clr-like EGF-like EGF_CA PF07645.15 VDK71327.1 - 1.6e-06 28.2 4.5 1.6e-06 28.2 4.5 10.1 6 5 1 8 8 8 1 Calcium-binding EGF domain SGL PF08450.12 VDK71327.1 - 7e-06 25.8 0.2 0.11 12.0 0.0 3.6 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region FXa_inhibition PF14670.6 VDK71327.1 - 0.00012 22.3 3.6 0.00012 22.3 3.6 6.9 6 1 0 6 6 6 2 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 VDK71327.1 - 0.003 17.8 0.4 0.003 17.8 0.4 8.3 9 1 0 9 9 9 2 Pvs28 EGF domain Band_3_cyto PF07565.13 VDK71329.1 - 8.2 6.1 10.5 19 5.0 6.4 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DNA_ligase_A_M PF01068.21 VDK71330.1 - 1.8e-60 204.1 0.1 3e-60 203.4 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 VDK71330.1 - 9.5e-42 143.3 0.2 2.1e-41 142.1 0.2 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 VDK71330.1 - 6.8e-24 84.3 0.0 5.5e-23 81.4 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region Sclerostin PF05463.11 VDK71332.1 - 0.0051 16.6 1.7 0.0074 16.0 1.7 1.3 1 0 0 1 1 1 1 Sclerostin (SOST) Fer2_3 PF13085.6 VDK71333.1 - 2.7e-33 114.2 0.1 5.1e-33 113.4 0.1 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 VDK71333.1 - 1.3e-08 35.3 4.5 1.3e-08 35.3 4.5 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 VDK71333.1 - 4.5e-08 33.1 2.9 4.5e-08 33.1 2.9 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 VDK71333.1 - 5.8e-07 29.9 8.0 5.8e-07 29.9 8.0 2.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 VDK71333.1 - 0.0068 16.6 1.0 0.21 11.8 0.1 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 VDK71333.1 - 0.012 15.7 6.3 0.012 15.7 6.3 2.8 2 2 0 2 2 2 0 4Fe-4S dicluster domain Fer2 PF00111.27 VDK71333.1 - 0.015 15.2 1.4 0.015 15.2 1.4 2.4 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 VDK71333.1 - 0.023 15.3 6.9 0.023 15.3 6.9 3.1 2 2 1 3 3 3 0 4Fe-4S dicluster domain Tudor_2 PF18104.1 VDK71334.1 - 0.02 14.6 0.1 0.05 13.3 0.1 1.6 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain Agenet PF05641.12 VDK71334.1 - 0.034 14.6 0.0 0.083 13.4 0.0 1.7 1 0 0 1 1 1 0 Agenet domain 2OG-FeII_Oxy_5 PF13759.6 VDK71334.1 - 0.13 12.7 0.1 0.29 11.6 0.1 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase ECH_1 PF00378.20 VDK71335.1 - 9.5e-31 107.0 0.0 1.8e-30 106.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ACBP PF00887.19 VDK71335.1 - 2.7e-20 72.4 0.5 6.2e-20 71.2 0.5 1.7 1 0 0 1 1 1 1 Acyl CoA binding protein ECH_2 PF16113.5 VDK71335.1 - 4.6e-16 59.2 0.0 1.6e-15 57.4 0.0 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Rad21_Rec8_N PF04825.13 VDK71335.1 - 4.9e-07 29.9 0.0 1.3e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein U3snoRNP10 PF12397.8 VDK71337.1 - 4.5e-09 36.7 3.6 2.4e-08 34.3 3.7 2.3 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 10 F-box_4 PF15966.5 VDK71337.1 - 0.019 14.8 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 F-box UNC119_bdg PF15435.6 VDK71337.1 - 0.11 12.1 2.0 9.9 5.6 0.1 2.6 3 0 0 3 3 3 0 UNC119-binding protein C5orf30 homologue ANAPC10 PF03256.16 VDK71374.1 - 0.049 13.3 0.0 0.053 13.2 0.0 1.0 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) Histone PF00125.24 VDK71376.1 - 1.3e-34 119.4 1.9 1.6e-34 119.1 1.9 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 VDK71376.1 - 0.0015 18.6 0.0 0.0026 17.9 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 VDK71376.1 - 0.033 14.6 0.0 0.058 13.8 0.0 1.4 1 0 0 1 1 1 0 CENP-S protein RNA_pol_Rpb6 PF01192.22 VDK71379.1 - 1.6e-13 50.3 0.1 2.4e-13 49.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 DUF4549 PF15082.6 VDK71379.1 - 0.081 12.7 0.0 0.097 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) VHP PF02209.19 VDK71381.1 - 4.6e-15 55.4 0.3 1.2e-14 54.1 0.3 1.8 1 0 0 1 1 1 1 Villin headpiece domain Gelsolin PF00626.22 VDK71381.1 - 3.6e-13 49.2 0.0 0.0037 17.1 0.0 4.7 4 0 0 4 4 4 4 Gelsolin repeat Helicase_C PF00271.31 VDK71383.1 - 1.8e-20 73.3 0.0 1.4e-18 67.3 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK71383.1 - 5.3e-17 62.1 0.0 1.3e-16 60.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 VDK71383.1 - 4.1e-14 53.0 1.7 9.4e-14 51.9 0.6 2.3 2 0 0 2 2 2 1 RecQ zinc-binding RQC PF09382.10 VDK71383.1 - 2e-12 46.9 0.3 5.4e-12 45.5 0.3 1.8 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 VDK71383.1 - 9e-10 38.4 0.0 2.3e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 VDK71383.1 - 3.1e-06 27.3 0.0 5.7e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3052 PF11253.8 VDK71383.1 - 0.087 12.7 0.2 1.1 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3052) Pkinase PF00069.25 VDK71386.1 - 2.9e-58 197.3 1.2 1.2e-57 195.3 0.0 2.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK71386.1 - 1.4e-28 99.9 3.1 1.7e-28 99.6 0.0 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase Rho_Binding PF08912.11 VDK71386.1 - 9.5e-06 26.3 7.3 9.5e-06 26.3 7.3 9.7 5 4 4 9 9 9 1 Rho Binding C1_1 PF00130.22 VDK71386.1 - 0.00045 20.0 0.7 0.001 18.9 0.7 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH PF00169.29 VDK71386.1 - 0.011 16.2 0.0 0.67 10.5 0.0 2.8 1 1 0 1 1 1 0 PH domain OrfB_Zn_ribbon PF07282.11 VDK71386.1 - 0.12 12.3 0.1 0.48 10.4 0.1 2.0 1 0 0 1 1 1 0 Putative transposase DNA-binding domain APH PF01636.23 VDK71386.1 - 0.22 11.4 0.1 0.22 11.4 0.1 4.4 2 2 1 4 4 4 0 Phosphotransferase enzyme family Pkinase_C PF00433.24 VDK71386.1 - 3.5 8.4 4.8 12 6.6 4.8 2.1 1 1 0 1 1 1 0 Protein kinase C terminal domain WD40 PF00400.32 VDK71388.1 - 4.2e-18 65.4 9.1 0.0038 18.0 0.0 8.3 8 1 0 8 8 8 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 VDK71388.1 - 0.03 13.3 0.0 0.22 10.4 0.0 2.4 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CPSF_A PF03178.15 VDK71388.1 - 0.1 11.9 0.0 0.81 8.9 0.0 2.1 2 0 0 2 2 2 0 CPSF A subunit region SUKH_5 PF14567.6 VDK71388.1 - 0.12 12.1 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Rap_GAP PF02145.15 VDK71391.1 - 9.2e-31 106.8 0.0 6.2e-30 104.1 0.0 2.0 2 0 0 2 2 2 1 Rap/ran-GAP Cir_N PF10197.9 VDK71392.1 - 1.3e-05 25.2 10.9 1.3e-05 25.2 10.9 5.0 4 1 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR HEAT PF02985.22 VDK71394.1 - 9e-05 22.4 7.6 1.8 9.0 0.0 5.8 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 VDK71394.1 - 0.1 13.0 0.2 13 6.3 0.0 3.9 6 0 0 6 6 6 0 HEAT repeats HEAT_EZ PF13513.6 VDK71394.1 - 0.26 11.8 7.8 0.54 10.8 0.2 4.9 6 1 0 6 6 6 0 HEAT-like repeat CH PF00307.31 VDK71395.1 - 7e-10 39.1 0.0 1.5e-09 38.0 0.0 1.5 1 1 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK71395.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain RRM_1 PF00076.22 VDK71397.1 - 3.2e-39 132.6 0.1 4.2e-14 52.1 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hnRNP_Q_AcD PF18360.1 VDK71397.1 - 6.8e-25 86.8 0.8 1.9e-24 85.4 0.2 2.1 2 0 0 2 2 2 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain RRM_5 PF13893.6 VDK71397.1 - 2.7e-06 27.0 0.0 1.1e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK71397.1 - 0.00041 20.4 0.0 12 6.2 0.0 4.3 3 1 1 4 4 4 2 RNA recognition motif RRM_2 PF04059.12 VDK71397.1 - 0.0027 17.9 0.0 1.9 8.7 0.0 3.0 2 1 1 3 3 3 2 RNA recognition motif 2 RRM_occluded PF16842.5 VDK71397.1 - 0.0036 17.1 0.0 0.066 13.1 0.0 2.6 2 0 0 2 2 2 1 Occluded RNA-recognition motif ATP-synt_ab PF00006.25 VDK71399.1 - 1.8e-73 246.8 0.0 2.8e-73 246.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 VDK71399.1 - 6.6e-46 155.7 3.3 1.1e-45 155.1 3.3 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 VDK71399.1 - 5.4e-17 62.1 1.6 1.3e-16 60.8 1.6 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF4142 PF13628.6 VDK71399.1 - 0.097 12.9 2.0 0.17 12.1 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) HTH_24 PF13412.6 VDK71399.1 - 0.13 11.8 0.8 3.8 7.2 0.0 2.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Ras PF00071.22 VDK71400.1 - 6.3e-67 224.2 0.3 7.9e-67 223.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK71400.1 - 2e-34 118.4 0.1 3.5e-34 117.6 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK71400.1 - 5.9e-17 61.7 0.3 8e-17 61.2 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK71400.1 - 4.5e-05 22.9 0.6 7.2e-05 22.2 0.6 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 VDK71400.1 - 7.9e-05 22.2 0.1 0.00011 21.6 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 VDK71400.1 - 0.001 18.7 0.1 0.0019 17.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK71400.1 - 0.0021 18.0 0.1 2.3 8.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 VDK71400.1 - 0.0033 17.5 0.0 0.0086 16.1 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_7 PF12775.7 VDK71400.1 - 0.028 13.9 0.0 0.054 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF3963 PF13124.6 VDK71400.1 - 0.029 14.4 0.8 0.058 13.4 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) MCM PF00493.23 VDK71400.1 - 0.09 11.9 0.0 0.28 10.2 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain Tropomodulin PF03250.14 VDK71401.1 - 1.8e-51 173.9 3.3 1.8e-51 173.9 3.3 1.7 2 0 0 2 2 2 1 Tropomodulin PDZ_5 PF17817.1 VDK71403.1 - 2.3e-14 53.4 0.2 2.3e-14 53.4 0.2 2.9 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.24 VDK71403.1 - 1.2e-11 44.8 1.1 2.7e-11 43.7 1.1 1.7 1 0 0 1 1 1 1 PDZ domain SAM_2 PF07647.17 VDK71403.1 - 5.6e-10 39.2 0.1 1.2e-09 38.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 VDK71403.1 - 3e-08 34.0 0.1 6.9e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_2 PF13180.6 VDK71403.1 - 0.022 15.1 0.1 0.056 13.8 0.1 1.6 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 VDK71403.1 - 0.023 14.5 2.4 0.34 10.8 0.2 3.0 3 0 0 3 3 3 0 PDZ domain HSBP1 PF06825.12 VDK71403.1 - 0.16 11.8 6.8 1.4 8.8 0.2 3.1 3 0 0 3 3 3 0 Heat shock factor binding protein 1 DUF745 PF05335.13 VDK71403.1 - 0.75 9.5 11.8 2.2 7.9 11.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Exonuc_VII_L PF02601.15 VDK71403.1 - 1.5 8.3 14.5 0.14 11.7 9.4 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit SpoIISA_toxin PF14171.6 VDK71403.1 - 1.8 8.2 4.8 3.5 7.3 4.8 1.4 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Pox_A_type_inc PF04508.12 VDK71403.1 - 2.7 8.0 23.0 0.028 14.2 4.2 4.4 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DUF2333 PF10095.9 VDK71403.1 - 3.7 6.5 7.3 9.8 5.1 7.3 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) XhlA PF10779.9 VDK71403.1 - 6.1 7.1 16.9 0.78 10.0 1.2 3.8 3 0 0 3 3 3 0 Haemolysin XhlA PDEase_I PF00233.19 VDK71405.1 - 4.8e-68 229.4 3.7 2.4e-67 227.1 1.2 2.1 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 VDK71405.1 - 9.7e-17 61.8 0.0 1.8e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 VDK71405.1 - 2.2e-08 34.5 0.0 6.1e-08 33.1 0.0 1.8 1 1 0 1 1 1 1 GAF domain GAF_2 PF13185.6 VDK71405.1 - 6.8e-08 32.9 0.0 1.1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 GAF domain SpoVT_C PF15714.5 VDK71405.1 - 0.051 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor DUF3932 PF13068.6 VDK71407.1 - 0.1 12.9 0.0 0.68 10.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3932) DUF2884 PF11101.8 VDK71432.1 - 0.00023 20.7 7.9 0.0032 17.0 1.3 3.2 1 1 0 2 2 2 1 Protein of unknown function (DUF2884) DUF4407 PF14362.6 VDK71432.1 - 0.0052 16.2 10.5 0.098 12.0 2.4 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) Dehydrin PF00257.19 VDK71432.1 - 0.019 15.5 2.0 0.045 14.3 2.0 1.6 1 0 0 1 1 1 0 Dehydrin dNK PF01712.19 VDK71432.1 - 0.027 14.3 4.3 0.051 13.4 3.8 1.7 1 1 0 1 1 1 0 Deoxynucleoside kinase WXG100 PF06013.12 VDK71432.1 - 0.032 14.5 3.0 0.31 11.3 0.1 3.5 3 1 0 3 3 3 0 Proteins of 100 residues with WXG BLOC1_2 PF10046.9 VDK71432.1 - 0.52 10.7 14.3 0.64 10.4 2.3 4.2 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2937 PF11157.8 VDK71432.1 - 0.86 9.3 2.9 1.5 8.5 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) Rx_N PF18052.1 VDK71432.1 - 3.1 8.1 12.7 0.57 10.5 4.4 3.1 2 1 0 3 3 3 0 Rx N-terminal domain TRAF_BIRC3_bd PF16673.5 VDK71432.1 - 5.5 6.9 8.6 1.6 8.6 0.3 3.7 3 1 1 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain Osmo_CC PF08946.10 VDK71432.1 - 6.2 7.2 12.5 2.1 8.7 0.7 4.3 5 0 0 5 5 5 0 Osmosensory transporter coiled coil Exonuc_VII_L PF02601.15 VDK71432.1 - 8.9 5.8 18.7 5.2e+02 -0.0 18.7 2.2 1 1 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_C14 PF00656.22 VDK71433.1 - 2.5e-14 53.8 0.0 3.9e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Caspase domain DUF3877 PF12993.7 VDK71433.1 - 0.00022 21.2 0.0 0.00039 20.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function, E. rectale Gene description (DUF3877) Ig_3 PF13927.6 VDK71433.1 - 0.0075 16.9 0.0 0.02 15.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 VDK71433.1 - 0.0094 16.3 0.1 0.03 14.7 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain I-set PF07679.16 VDK71433.1 - 0.063 13.3 0.0 0.2 11.8 0.0 1.9 1 1 0 1 1 1 0 Immunoglobulin I-set domain CUT PF02376.15 VDK71434.1 - 1.1e-30 105.6 0.0 2.1e-30 104.7 0.0 1.5 1 0 0 1 1 1 1 CUT domain Homeodomain PF00046.29 VDK71434.1 - 4.6e-11 42.4 2.4 1.1e-10 41.2 2.4 1.7 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK71434.1 - 0.0013 18.6 0.1 0.0037 17.1 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain EF-hand_5 PF13202.6 VDK71437.1 - 0.00021 20.6 2.2 0.0011 18.4 0.6 2.6 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 VDK71437.1 - 0.00025 20.4 4.0 0.00034 20.0 1.3 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 VDK71437.1 - 0.0023 17.8 1.5 0.0084 15.9 1.5 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK71437.1 - 0.0043 16.9 0.8 0.0043 16.9 0.8 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 VDK71437.1 - 0.0095 16.4 4.6 0.0097 16.3 0.9 2.7 3 1 0 3 3 3 1 EF-hand domain pair EF_assoc_2 PF08356.12 VDK71437.1 - 0.019 14.9 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 EF hand associated EF-hand_6 PF13405.6 VDK71438.1 - 2.6e-19 67.4 6.8 6.4e-05 22.6 0.0 5.5 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 VDK71438.1 - 1.6e-18 64.8 12.0 3.9e-06 26.0 0.8 5.5 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 VDK71438.1 - 1e-16 61.1 9.4 9.3e-10 38.8 2.9 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK71438.1 - 1.4e-13 49.7 11.5 9.6e-05 21.7 0.9 5.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 VDK71438.1 - 4.1e-11 42.5 10.4 8.9e-08 31.9 1.9 4.1 4 0 0 4 4 4 3 EF-hand domain pair p25-alpha PF05517.12 VDK71438.1 - 0.00051 20.3 0.5 0.011 15.9 0.0 2.3 1 1 1 2 2 2 1 p25-alpha Caleosin PF05042.13 VDK71438.1 - 0.019 14.9 0.3 1.3 8.9 0.0 2.3 2 0 0 2 2 2 0 Caleosin related protein EF-hand_11 PF08976.11 VDK71438.1 - 0.027 15.4 0.1 0.074 13.9 0.0 1.8 2 1 0 2 2 2 0 EF-hand domain Xpo1 PF08389.12 VDK71439.1 - 1e-26 93.8 6.6 1.7e-25 89.9 0.4 3.5 3 0 0 3 3 3 2 Exportin 1-like protein IBN_N PF03810.19 VDK71439.1 - 0.00044 20.1 0.3 0.0014 18.5 0.3 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain Alba PF01918.21 VDK71439.1 - 0.005 16.6 0.0 0.014 15.2 0.0 1.7 1 0 0 1 1 1 1 Alba Vac14_Fab1_bd PF12755.7 VDK71439.1 - 0.0074 16.9 0.2 0.07 13.7 0.0 2.9 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region Picorna_P3A PF06363.11 VDK71439.1 - 0.02 14.7 0.2 0.12 12.3 0.0 2.4 2 0 0 2 2 2 0 Picornaviridae P3A protein BAG6 PF12057.8 VDK71439.1 - 0.3 10.8 1.2 0.96 9.1 0.0 2.4 3 0 0 3 3 3 0 BCL2-associated athanogene 6 MAT1 PF06391.13 VDK71440.1 - 6.6e-31 107.7 22.3 2.8e-27 95.9 4.3 2.0 1 1 1 2 2 2 2 CDK-activating kinase assembly factor MAT1 zf-C3HC4 PF00097.25 VDK71440.1 - 7.6e-06 25.7 4.1 1.6e-05 24.7 4.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK71440.1 - 0.00017 21.3 3.0 0.00033 20.5 3.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK71440.1 - 0.00046 20.1 2.7 0.00095 19.1 2.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 VDK71440.1 - 0.00054 19.7 3.7 0.00054 19.7 3.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 VDK71440.1 - 0.00068 19.5 4.5 0.0013 18.5 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK71440.1 - 0.0019 18.0 1.5 0.0035 17.2 1.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-UDP PF14569.6 VDK71440.1 - 0.0021 18.1 0.3 0.0047 17.0 0.3 1.6 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-RING_2 PF13639.6 VDK71440.1 - 0.0024 18.2 3.0 0.005 17.2 3.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 VDK71440.1 - 0.0034 17.1 3.1 0.0073 16.1 3.1 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 VDK71440.1 - 0.0052 16.9 3.4 0.011 15.8 3.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING DUF5376 PF17346.2 VDK71440.1 - 0.025 14.9 2.4 0.04 14.3 1.2 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5376) zf-RING_UBOX PF13445.6 VDK71440.1 - 0.04 14.0 2.6 0.097 12.7 2.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DUF5600 PF18150.1 VDK71440.1 - 0.17 12.5 1.9 1.3 9.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5600) MobL PF18555.1 VDK71440.1 - 2 7.6 10.2 2.6 7.2 10.2 1.1 1 0 0 1 1 1 0 MobL relaxases Complex1_LYR PF05347.15 VDK71441.1 - 4.7e-15 55.4 1.5 6.2e-15 55.0 1.5 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 VDK71441.1 - 9.5e-06 26.3 0.5 1e-05 26.2 0.5 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 VDK71441.1 - 0.00036 21.1 0.0 0.00041 20.9 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Band_7_1 PF13421.6 VDK71441.1 - 0.0049 16.6 0.0 0.0058 16.4 0.0 1.1 1 0 0 1 1 1 1 SPFH domain-Band 7 family SKICH PF17751.1 VDK71441.1 - 0.043 14.4 0.1 0.053 14.1 0.1 1.2 1 0 0 1 1 1 0 SKICH domain YfiO PF13525.6 VDK71441.1 - 0.046 13.5 0.5 0.053 13.2 0.5 1.0 1 0 0 1 1 1 0 Outer membrane lipoprotein FAT PF02259.23 VDK71443.1 - 3e-25 89.2 5.4 3e-25 89.2 5.4 2.1 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 VDK71443.1 - 2.7e-09 37.2 0.1 7e-09 35.9 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TPR_1 PF00515.28 VDK71443.1 - 0.00019 21.1 0.5 0.086 12.7 0.3 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK71443.1 - 0.0017 18.3 0.2 0.64 10.3 0.1 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ARL2_Bind_BART PF11527.8 VDK71443.1 - 0.019 15.1 6.9 0.79 9.8 1.0 4.4 4 0 0 4 4 4 0 The ARF-like 2 binding protein BART Cnd1 PF12717.7 VDK71443.1 - 0.41 10.7 13.7 2.8 8.0 0.0 5.8 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 SapB_2 PF03489.17 VDK71443.1 - 0.59 10.3 3.2 12 6.2 0.4 3.4 3 0 0 3 3 3 0 Saposin-like type B, region 2 TPR_12 PF13424.6 VDK71443.1 - 4.2 7.7 5.1 11 6.4 0.3 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat HLH PF00010.26 VDK71445.1 - 1.8e-16 59.8 5.9 1.9e-16 59.8 4.3 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain WD40 PF00400.32 VDK71447.1 - 2e-38 129.7 16.1 4e-06 27.5 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK71447.1 - 6.6e-13 48.8 0.0 0.005 17.1 0.1 5.1 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK71447.1 - 0.011 15.1 0.0 0.57 9.4 0.0 2.8 2 1 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.16 VDK71447.1 - 0.11 11.0 0.0 0.73 8.3 0.0 2.2 3 0 0 3 3 3 0 Cytochrome D1 heme domain CALM_bind PF16025.5 VDK71447.1 - 0.15 12.6 1.0 0.24 11.9 1.0 1.3 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Myc-LZ PF02344.15 VDK71447.1 - 0.16 12.1 1.1 0.27 11.4 1.1 1.3 1 0 0 1 1 1 0 Myc leucine zipper domain DUF1847 PF08901.11 VDK71449.1 - 0.24 11.1 2.7 0.19 11.4 1.4 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1847) DUF851 PF05867.11 VDK71452.1 - 2.5e-10 40.2 0.1 4.2e-10 39.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF851) PAN_1 PF00024.26 VDK71453.1 - 0.0014 18.5 0.6 0.003 17.5 0.6 1.5 1 0 0 1 1 1 1 PAN domain PAN_3 PF08277.12 VDK71453.1 - 0.043 13.6 0.1 0.081 12.7 0.1 1.3 1 0 0 1 1 1 0 PAN-like domain Motile_Sperm PF00635.26 VDK71499.1 - 7.2e-22 77.3 0.0 1.7e-21 76.1 0.0 1.5 2 0 0 2 2 2 1 MSP (Major sperm protein) domain Band_7 PF01145.25 VDK71500.1 - 1.5e-13 51.2 0.7 2.8e-13 50.2 0.7 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family SCP2 PF02036.17 VDK71500.1 - 5.2e-12 46.1 0.0 1.2e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 VDK71500.1 - 7.3e-05 23.0 0.0 0.00035 20.9 0.0 2.0 2 0 0 2 2 2 1 Alkyl sulfatase C-terminal Arf PF00025.21 VDK71502.1 - 2.3e-79 264.9 0.1 2.6e-79 264.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK71502.1 - 3.4e-14 53.1 0.0 4.6e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 VDK71502.1 - 3.4e-14 52.8 1.1 2.7e-10 39.9 0.3 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 VDK71502.1 - 6.9e-14 51.7 0.0 8.3e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 VDK71502.1 - 2e-12 47.0 0.0 2.3e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 VDK71502.1 - 1.9e-11 43.8 0.0 2.4e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK71502.1 - 3.2e-06 27.2 0.0 4.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 VDK71502.1 - 0.004 16.5 0.4 0.01 15.2 0.4 1.7 1 1 0 1 1 1 1 6-phosphofructo-2-kinase MIF4G PF02854.19 VDK71503.1 - 5.6e-40 137.2 5.8 3.2e-26 92.3 0.0 3.5 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.14 VDK71503.1 - 1.9e-12 48.1 1.6 1.9e-12 48.1 1.6 2.3 2 0 0 2 2 2 1 Up-frameshift suppressor 2 KNOX2 PF03791.13 VDK71503.1 - 0.81 9.2 4.6 0.93 9.1 0.0 3.5 5 0 0 5 5 5 0 KNOX2 domain BLOC1_2 PF10046.9 VDK71503.1 - 5.6 7.3 7.9 0.82 10.0 1.1 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MAM PF00629.23 VDK71505.1 - 1.5e-16 60.7 0.6 1.5e-05 24.9 0.0 5.0 4 2 0 4 4 4 4 MAM domain, meprin/A5/mu Ank_2 PF12796.7 VDK71507.1 - 7.6e-18 64.9 0.9 2.4e-06 28.1 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK71507.1 - 1.1e-14 54.3 1.2 4.1e-05 23.8 0.0 4.7 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 VDK71507.1 - 3.8e-14 52.4 0.7 0.00058 20.2 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 VDK71507.1 - 1.2e-13 49.9 1.2 0.006 17.0 0.0 6.7 7 0 0 7 7 7 2 Ankyrin repeat Ank_4 PF13637.6 VDK71507.1 - 1.3e-12 48.0 0.2 1.7e-06 28.5 0.0 4.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Neur_chan_LBD PF02931.23 VDK71508.1 - 2.9e-42 144.6 0.5 4.2e-42 144.0 0.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK71508.1 - 0.00026 21.1 0.4 0.00044 20.4 0.4 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region MH2 PF03166.14 VDK71510.1 - 7.5e-67 225.2 0.2 2e-66 223.8 0.0 1.8 2 0 0 2 2 2 1 MH2 domain MH1 PF03165.16 VDK71510.1 - 1.2e-37 128.2 0.6 3.7e-37 126.7 0.6 1.9 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 VDK71510.1 - 0.026 14.3 0.0 0.054 13.3 0.0 1.4 1 0 0 1 1 1 0 Interferon-regulatory factor 3 PSD2 PF07624.11 VDK71510.1 - 0.027 14.2 0.0 0.058 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) CBP_BcsQ PF06564.12 VDK71511.1 - 0.026 14.0 0.1 0.026 14.0 0.1 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Nucleoside_tran PF01733.18 VDK71512.1 - 3.6e-70 236.8 19.9 6.1e-70 236.0 19.9 1.3 1 0 0 1 1 1 1 Nucleoside transporter OAD_gamma PF04277.13 VDK71512.1 - 0.61 10.7 0.1 0.61 10.7 0.1 3.1 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain PilX_N PF14341.6 VDK71512.1 - 8.1 6.5 11.6 7.1 6.7 0.2 3.4 3 0 0 3 3 3 0 PilX N-terminal LLGL PF08366.13 VDK71514.1 - 7.8e-31 106.5 0.0 1e-29 102.9 0.0 2.6 2 0 0 2 2 2 1 LLGL2 ANAPC4_WD40 PF12894.7 VDK71514.1 - 7.2e-08 32.6 0.0 0.15 12.4 0.0 4.9 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK71514.1 - 2.6e-07 31.2 6.4 0.12 13.3 1.0 5.7 6 0 0 6 6 6 2 WD domain, G-beta repeat Lgl_C PF08596.10 VDK71514.1 - 0.0074 15.0 0.0 0.33 9.6 0.0 2.6 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal Fungal_lectin PF07938.12 VDK71517.1 - 0.044 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Fungal fucose-specific lectin DUF1869 PF08956.10 VDK71517.1 - 0.11 12.5 0.9 0.35 10.8 0.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) TM_PBP2_N PF16296.5 VDK71517.1 - 0.16 12.1 0.3 0.43 10.7 0.1 1.7 2 0 0 2 2 2 0 N-terminal of TM subunit in PBP-dependent ABC transporters zf-C2H2_4 PF13894.6 VDK71517.1 - 0.3 12.1 1.4 0.81 10.7 1.4 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger Neuralized PF07177.12 VDK71518.1 - 1.9e-90 300.6 0.0 3.5e-47 160.2 0.0 2.3 2 0 0 2 2 2 2 Neuralized zf-C3HC4_3 PF13920.6 VDK71518.1 - 5.8e-13 48.5 10.8 1e-12 47.7 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK71518.1 - 3.9e-06 26.6 10.5 7.5e-06 25.7 10.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 VDK71518.1 - 3.5e-05 24.0 13.3 7.7e-05 22.9 13.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK71518.1 - 0.0013 18.5 13.0 0.0025 17.6 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) HNOB PF07700.15 VDK71518.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Haem-NO-binding zf-RING_5 PF14634.6 VDK71518.1 - 0.16 11.9 13.0 0.36 10.8 13.0 1.6 1 0 0 1 1 1 0 zinc-RING finger domain TB2_DP1_HVA22 PF03134.19 VDK71549.1 - 1.3e-26 92.3 4.5 2.3e-26 91.5 4.5 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family CC PF04942.14 VDK71549.1 - 3e-05 24.1 23.1 0.0006 20.0 15.8 4.0 3 1 1 4 4 4 2 CC domain KH_1 PF00013.29 VDK71551.1 - 4.8e-36 122.4 9.6 3e-12 46.2 0.4 4.1 4 0 0 4 4 4 3 KH domain KH_2 PF07650.17 VDK71551.1 - 2.7e-10 39.9 7.9 6.9e-05 22.6 1.0 3.3 2 1 1 3 3 3 2 KH domain KH_4 PF13083.6 VDK71551.1 - 5.8e-06 26.1 1.9 0.016 15.1 0.0 3.8 4 0 0 4 4 4 2 KH domain KH_5 PF13184.6 VDK71551.1 - 0.00078 19.5 3.3 0.12 12.4 0.1 3.1 3 0 0 3 3 3 2 NusA-like KH domain HLH PF00010.26 VDK71552.1 - 4.1e-11 42.7 0.7 4.1e-11 42.7 0.7 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DivIC PF04977.15 VDK71552.1 - 0.0015 18.2 1.5 0.0019 18.0 0.3 1.7 2 0 0 2 2 2 1 Septum formation initiator ZapB PF06005.12 VDK71552.1 - 0.016 15.7 1.2 0.058 13.8 0.3 2.2 2 0 0 2 2 2 0 Cell division protein ZapB Sipho_Gp157 PF05565.11 VDK71552.1 - 0.022 14.8 0.4 0.027 14.5 0.4 1.2 1 0 0 1 1 1 0 Siphovirus Gp157 DUF4391 PF14335.6 VDK71552.1 - 0.023 14.4 0.6 0.03 14.0 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) HALZ PF02183.18 VDK71552.1 - 0.044 14.0 2.7 0.09 13.0 1.1 2.2 2 1 1 3 3 3 0 Homeobox associated leucine zipper Mod_r PF07200.13 VDK71552.1 - 0.12 12.4 3.3 0.12 12.4 1.9 1.7 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 VDK71552.1 - 0.21 12.2 2.9 0.29 11.8 1.1 1.9 1 1 0 2 2 2 0 Initiation control protein YabA NRBF2 PF08961.10 VDK71552.1 - 0.88 9.1 6.0 1.7 8.2 6.0 1.6 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator PLDc_2 PF13091.6 VDK71556.1 - 4e-17 62.3 0.0 5.8e-09 35.9 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 VDK71556.1 - 9.5e-08 31.9 0.9 0.00071 19.6 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif IDO PF01231.18 VDK71559.1 - 2.2e-80 270.6 0.0 1.3e-79 268.0 0.0 1.8 1 1 1 2 2 2 2 Indoleamine 2,3-dioxygenase PHD PF00628.29 VDK71560.1 - 8.7e-08 31.9 8.7 1.9e-07 30.9 8.7 1.6 1 0 0 1 1 1 1 PHD-finger Amidinotransf PF02274.17 VDK71560.1 - 0.0027 16.8 0.0 0.0042 16.2 0.0 1.3 1 0 0 1 1 1 1 Amidinotransferase PHD_2 PF13831.6 VDK71560.1 - 0.008 15.7 1.1 0.008 15.7 1.1 2.3 2 1 0 2 2 2 1 PHD-finger C1_1 PF00130.22 VDK71560.1 - 0.013 15.4 7.2 0.013 15.4 7.2 2.2 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 VDK71560.1 - 1 9.7 9.9 0.32 11.4 4.9 2.5 2 0 0 2 2 2 0 C1 domain PHD_4 PF16866.5 VDK71560.1 - 1.6 8.9 10.8 4 7.6 10.1 2.1 1 1 0 1 1 1 0 PHD-finger BAG PF02179.16 VDK71561.1 - 5.3e-07 30.0 0.8 9.3e-07 29.2 0.8 1.4 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 VDK71561.1 - 0.0033 17.1 0.0 0.0058 16.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family SKA2 PF16740.5 VDK71561.1 - 0.03 14.1 0.8 0.1 12.4 0.4 2.0 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 RBD-FIP PF09457.10 VDK71561.1 - 0.054 13.4 0.4 0.24 11.3 0.2 2.1 2 0 0 2 2 2 0 FIP domain RRM_1 PF00076.22 VDK71562.1 - 5.1e-39 132.0 0.1 9.3e-16 57.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK71562.1 - 8.4e-05 22.6 0.0 0.39 10.8 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif DUF3005 PF11448.8 VDK71562.1 - 0.051 13.6 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) HicB-like_2 PF15970.5 VDK71562.1 - 0.16 12.1 0.4 1.4 9.1 0.1 2.4 2 0 0 2 2 2 0 HicB_like antitoxin of bacterial toxin-antitoxin system OB_RNB PF08206.11 VDK71562.1 - 0.25 11.0 0.4 0.69 9.6 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease B OB domain DcpS_C PF11969.8 VDK71567.1 - 1.6e-19 70.4 0.7 2.4e-19 69.9 0.7 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 VDK71567.1 - 6.2e-06 26.9 4.3 1.3e-05 25.9 3.0 2.1 2 1 0 2 2 2 1 HIT domain BTB PF00651.31 VDK71568.1 - 2.5e-09 37.4 0.0 1.2e-08 35.1 0.0 2.2 2 1 0 2 2 2 1 BTB/POZ domain Cnd3 PF12719.7 VDK71569.1 - 3.4e-50 170.9 2.3 4.2e-50 170.6 0.6 2.0 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT PF02985.22 VDK71569.1 - 0.088 13.1 6.3 12 6.4 0.1 5.5 5 0 0 5 5 5 0 HEAT repeat HEAT_2 PF13646.6 VDK71569.1 - 0.11 12.9 7.6 7.1 7.1 0.2 4.1 5 1 0 5 5 5 0 HEAT repeats Cnd1 PF12717.7 VDK71569.1 - 0.33 11.0 3.9 2.3 8.2 0.1 3.7 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Abhydro_lipase PF04083.16 VDK71571.1 - 3.5e-20 71.3 0.0 7e-20 70.4 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 VDK71571.1 - 1.8e-09 37.7 0.6 1.6e-07 31.2 0.6 2.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK71571.1 - 0.017 14.4 0.0 1 8.6 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK71573.1 - 1.3e-10 41.4 0.5 2.1e-09 37.4 0.5 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK71573.1 - 0.0047 16.2 0.0 0.028 13.7 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DDOST_48kD PF03345.14 VDK71574.1 - 0.0066 15.3 0.0 0.24 10.2 0.0 2.1 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta ABC_transp_aux PF09822.9 VDK71574.1 - 0.067 12.7 0.0 0.17 11.3 0.0 1.7 1 0 0 1 1 1 0 ABC-type uncharacterized transport system BTB PF00651.31 VDK71576.1 - 8.1e-24 84.0 0.4 1.6e-22 79.8 0.0 2.4 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 VDK71576.1 - 1.4e-18 66.9 0.3 7.1e-18 64.6 0.1 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch F5_F8_type_C PF00754.25 VDK71576.1 - 2.7e-12 46.9 0.0 3.5e-05 23.9 0.0 2.2 2 0 0 2 2 2 2 F5/8 type C domain Pkinase PF00069.25 VDK71577.1 - 2.1e-15 56.8 0.3 6.4e-15 55.2 0.1 1.7 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK71577.1 - 4.4e-08 32.7 1.0 9.6e-08 31.6 1.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase RPEL PF02755.15 VDK71577.1 - 0.075 12.8 0.0 0.2 11.4 0.0 1.7 1 0 0 1 1 1 0 RPEL repeat DUF3307 PF11750.8 VDK71577.1 - 1.2 9.2 5.2 0.19 11.8 0.3 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3307) Fringe PF02434.16 VDK71580.1 - 4.1e-55 187.0 0.0 3.5e-48 164.2 0.0 2.1 2 0 0 2 2 2 2 Fringe-like Rab5ip PF07019.12 VDK71580.1 - 2.3e-13 50.5 6.3 5.1e-13 49.4 6.3 1.6 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Galactosyl_T PF01762.21 VDK71580.1 - 0.00014 21.7 0.2 0.12 12.2 0.0 3.7 2 1 1 3 3 3 1 Galactosyltransferase Choline_transpo PF04515.12 VDK71580.1 - 0.045 12.9 0.9 0.072 12.3 0.9 1.2 1 0 0 1 1 1 0 Plasma-membrane choline transporter Glycos_transf_2 PF00535.26 VDK71580.1 - 0.092 12.6 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 RNase_H PF00075.24 VDK71581.1 - 2e-14 54.0 0.0 6.7e-14 52.3 0.0 1.8 1 1 0 1 1 1 1 RNase H Cu2_monoox_C PF03712.15 VDK71581.1 - 0.043 13.3 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 Copper type II ascorbate-dependent monooxygenase, C-terminal domain zf-C3HC4 PF00097.25 VDK71583.1 - 5.1e-05 23.1 56.9 0.008 16.0 8.4 5.4 3 1 2 5 5 5 3 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK71583.1 - 0.0019 18.2 7.2 0.0019 18.2 7.2 5.4 4 1 0 4 4 4 3 RING-type zinc-finger zf-RING_2 PF13639.6 VDK71583.1 - 0.0058 16.9 7.0 0.0058 16.9 7.0 5.1 3 1 1 4 4 4 2 Ring finger domain zf-C3HC4_2 PF13923.6 VDK71583.1 - 0.027 14.3 3.8 0.027 14.3 3.8 5.5 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) HSM3_C PF18794.1 VDK71583.1 - 0.16 11.6 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, C terminal domain zf-RING_5 PF14634.6 VDK71583.1 - 1 9.4 62.5 0.21 11.6 9.7 4.9 3 1 1 4 4 4 0 zinc-RING finger domain Dna2 PF08696.11 VDK71612.1 - 0.17 11.7 6.4 0.33 10.7 5.7 1.7 1 1 0 1 1 1 0 DNA replication factor Dna2 DUF262 PF03235.14 VDK71612.1 - 0.73 10.0 11.4 8 6.6 11.4 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF262 Seryl_tRNA_N PF02403.22 VDK71612.1 - 0.8 10.0 18.5 1.4 9.2 8.4 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Uso1_p115_C PF04871.13 VDK71612.1 - 6.7 7.1 20.7 2.2 8.7 17.6 1.8 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region TMPIT PF07851.13 VDK71612.1 - 7.6 5.7 10.0 14 4.8 10.0 1.4 1 0 0 1 1 1 0 TMPIT-like protein Zona_pellucida PF00100.23 VDK71613.1 - 2e-11 44.2 11.0 3e-11 43.6 11.0 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain PIH1 PF08190.12 VDK71613.1 - 0.00028 20.4 0.2 0.00044 19.8 0.2 1.2 1 0 0 1 1 1 1 PIH1 N-terminal domain PNK3P PF08645.11 VDK71614.1 - 7.7e-54 181.8 0.2 3.4e-53 179.7 0.1 1.9 2 0 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 VDK71614.1 - 5.2e-17 62.3 0.1 3.7e-14 53.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 VDK71614.1 - 1.5e-05 24.4 0.2 0.12 11.6 0.0 2.3 1 1 1 2 2 2 2 Zeta toxin AAA_18 PF13238.6 VDK71614.1 - 9.7e-05 22.9 0.1 0.00026 21.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain KTI12 PF08433.10 VDK71614.1 - 0.00028 20.5 1.0 0.15 11.5 1.0 2.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 VDK71614.1 - 0.00068 20.1 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain tRNA_lig_kinase PF08303.11 VDK71614.1 - 0.00075 19.6 0.0 0.002 18.3 0.0 1.7 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA PF00004.29 VDK71614.1 - 0.00076 19.9 0.0 0.0028 18.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 VDK71614.1 - 0.0025 18.2 0.0 0.0066 16.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase SKI PF01202.22 VDK71614.1 - 0.0045 17.1 0.2 0.09 12.9 0.1 2.6 2 1 1 3 3 3 1 Shikimate kinase MMR_HSR1 PF01926.23 VDK71614.1 - 0.0061 16.6 0.0 0.023 14.8 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_17 PF13207.6 VDK71614.1 - 0.0087 16.5 0.0 0.023 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 VDK71614.1 - 0.013 15.4 0.1 0.049 13.6 0.1 2.2 2 1 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 VDK71614.1 - 0.027 14.7 0.1 0.07 13.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain MANEC PF07502.14 VDK71614.1 - 0.029 14.6 1.2 0.13 12.6 1.2 2.1 1 1 0 1 1 1 0 MANEC domain AAA_28 PF13521.6 VDK71614.1 - 0.032 14.5 0.0 0.074 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 VDK71614.1 - 0.036 13.8 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Cytidylate_kin2 PF13189.6 VDK71614.1 - 0.039 14.1 0.0 0.089 12.9 0.0 1.6 1 0 0 1 1 1 0 Cytidylate kinase-like family RsgA_GTPase PF03193.16 VDK71614.1 - 0.04 13.8 0.0 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase NB-ARC PF00931.22 VDK71614.1 - 0.06 12.5 0.1 0.17 11.1 0.0 1.7 2 0 0 2 2 2 0 NB-ARC domain AAA_5 PF07728.14 VDK71614.1 - 0.06 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 VDK71614.1 - 0.064 12.8 0.0 0.82 9.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Hydrolase_6 PF13344.6 VDK71614.1 - 0.073 13.2 0.0 0.68 10.1 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Mg_chelatase PF01078.21 VDK71614.1 - 0.074 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 VDK71614.1 - 0.096 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter HAD_SAK_2 PF18143.1 VDK71614.1 - 0.11 12.8 0.0 2.5 8.4 0.0 2.3 2 0 0 2 2 2 0 HAD domain in Swiss Army Knife RNA repair proteins Nuc_sug_transp PF04142.15 VDK71616.1 - 3e-104 348.6 21.7 1.1e-102 343.5 14.8 2.1 1 1 1 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 VDK71616.1 - 1.2e-05 25.5 4.6 1.2e-05 25.5 4.6 2.3 2 0 0 2 2 2 1 EamA-like transporter family PUNUT PF16913.5 VDK71616.1 - 7.2e-05 22.2 3.2 7.2e-05 22.2 3.2 2.3 2 1 1 3 3 3 1 Purine nucleobase transmembrane transport UAA PF08449.11 VDK71616.1 - 0.0065 15.7 16.0 0.014 14.6 16.0 1.6 1 1 0 1 1 1 1 UAA transporter family Myosin_head PF00063.21 VDK71621.1 - 8e-294 976.1 3.3 8e-294 976.1 3.3 2.7 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 VDK71621.1 - 8.9e-154 513.9 271.3 1.1e-153 513.5 271.3 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 VDK71621.1 - 1.6e-15 56.7 0.5 3.6e-15 55.5 0.5 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.21 VDK71621.1 - 2.4e-05 24.1 44.5 2.4e-05 24.1 44.5 8.3 1 1 6 7 7 7 2 Intermediate filament protein THP2 PF09432.10 VDK71621.1 - 0.00022 21.3 10.6 0.00022 21.3 10.6 10.1 2 2 9 12 12 12 1 Tho complex subunit THP2 AAA_19 PF13245.6 VDK71621.1 - 0.49 10.7 4.6 1.6 9.1 0.0 3.4 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 VDK71621.1 - 0.71 10.2 0.0 0.71 10.2 0.0 6.6 6 3 3 9 9 9 0 AAA domain MscS_porin PF12795.7 VDK71621.1 - 2.2 7.7 242.2 0.058 12.9 16.7 10.7 1 1 10 11 11 11 0 Mechanosensitive ion channel porin domain PAN_1 PF00024.26 VDK71622.1 - 5.7e-15 55.0 22.4 3.9e-08 33.2 0.1 3.8 4 0 0 4 4 4 3 PAN domain PAN_3 PF08277.12 VDK71622.1 - 0.097 12.5 7.3 0.99 9.3 0.8 3.6 3 0 0 3 3 3 0 PAN-like domain BTD PF09270.10 VDK71623.1 - 3.3e-71 238.5 0.0 5.1e-71 237.9 0.0 1.3 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain LAG1-DNAbind PF09271.11 VDK71623.1 - 3.6e-52 177.0 0.8 6.3e-52 176.2 0.8 1.4 1 0 0 1 1 1 1 LAG1, DNA binding Nucleolin_bd PF16725.5 VDK71623.1 - 0.32 10.7 2.8 0.75 9.5 2.8 1.6 1 0 0 1 1 1 0 Nucleolin binding domain PWI PF01480.17 VDK71632.1 - 0.045 14.1 0.6 0.13 12.6 0.6 1.8 1 0 0 1 1 1 0 PWI domain FokI_C PF02980.16 VDK71632.1 - 1.9 8.5 3.9 0.87 9.6 0.2 2.3 3 0 0 3 3 3 0 Restriction endonuclease FokI, catalytic domain C2 PF00168.30 VDK71634.1 - 5e-19 68.5 0.0 1.4e-18 67.0 0.0 1.8 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 VDK71634.1 - 0.0018 18.1 0.1 0.0051 16.6 0.1 1.7 1 0 0 1 1 1 1 PDZ domain Erf4 PF10256.9 VDK71634.1 - 0.057 13.5 0.0 3.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Adenosine_kin PF04008.14 VDK71634.1 - 0.059 13.2 0.1 0.18 11.6 0.1 1.8 2 0 0 2 2 2 0 Adenosine specific kinase S-methyl_trans PF02574.16 VDK71635.1 - 4.9e-64 216.7 0.1 5.5e-64 216.6 0.1 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Cucumopine_C PF18631.1 VDK71635.1 - 0.0078 16.2 0.0 0.019 14.9 0.0 1.6 2 0 0 2 2 2 1 Cucumopine synthase C-terminal helical bundle domain Ku PF02735.16 VDK71636.1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ku70/Ku80 beta-barrel domain VWA_2 PF13519.6 VDK71636.1 - 0.19 12.4 0.4 0.7 10.6 0.4 2.0 1 1 0 1 1 1 0 von Willebrand factor type A domain Ku PF02735.16 VDK71637.1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ku70/Ku80 beta-barrel domain VWA_2 PF13519.6 VDK71637.1 - 0.19 12.4 0.4 0.7 10.6 0.4 2.0 1 1 0 1 1 1 0 von Willebrand factor type A domain S-methyl_trans PF02574.16 VDK71638.1 - 4.9e-64 216.7 0.1 5.5e-64 216.6 0.1 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Cucumopine_C PF18631.1 VDK71638.1 - 0.0078 16.2 0.0 0.019 14.9 0.0 1.6 2 0 0 2 2 2 1 Cucumopine synthase C-terminal helical bundle domain C2 PF00168.30 VDK71640.1 - 5.6e-19 68.3 0.0 1.4e-18 67.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 VDK71640.1 - 0.0018 18.1 0.1 0.005 16.6 0.1 1.7 1 0 0 1 1 1 1 PDZ domain Adenosine_kin PF04008.14 VDK71640.1 - 0.062 13.1 0.1 0.18 11.6 0.1 1.7 2 0 0 2 2 2 0 Adenosine specific kinase Erf4 PF10256.9 VDK71640.1 - 0.11 12.6 0.0 7 6.8 0.0 2.4 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family LIN37 PF15306.6 VDK71661.1 - 3e-18 66.5 2.2 5.3e-18 65.7 2.2 1.4 1 0 0 1 1 1 1 LIN37 Calreticulin PF00262.18 VDK71662.1 - 8.4e-152 505.3 12.7 8.4e-152 505.3 12.7 1.5 2 0 0 2 2 2 1 Calreticulin family Connexin PF00029.19 VDK71662.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Connexin Vut_1 PF02592.15 VDK71662.1 - 0.097 13.0 0.3 0.16 12.3 0.3 1.2 1 0 0 1 1 1 0 Putative vitamin uptake transporter TRAP_alpha PF03896.16 VDK71662.1 - 0.11 11.7 0.5 0.25 10.5 0.5 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Herpes_LMP1 PF05297.11 VDK71662.1 - 0.11 11.7 8.4 0.3 10.2 0.0 2.4 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) EphA2_TM PF14575.6 VDK71662.1 - 0.2 12.5 0.4 0.7 10.8 0.1 2.2 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Pan3_PK PF18101.1 VDK71663.1 - 8.2e-63 210.5 0.4 1.5e-62 209.6 0.4 1.5 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 VDK71663.1 - 0.00013 21.5 0.0 0.00024 20.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain PB1 PF00564.24 VDK71663.1 - 0.076 13.0 0.0 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 PB1 domain Anillin PF08174.11 VDK71664.1 - 9.4e-19 68.2 0.0 3.2e-18 66.5 0.0 2.0 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 VDK71664.1 - 1.6e-10 41.4 2.6 4.5e-10 40.0 0.0 2.9 3 0 0 3 3 3 1 PH domain PH_11 PF15413.6 VDK71664.1 - 0.11 12.9 0.4 3.7 8.0 0.4 3.3 1 1 0 1 1 1 0 Pleckstrin homology domain Cullin PF00888.22 VDK71665.1 - 5.1e-153 511.0 5.4 5.1e-153 511.0 5.4 1.5 1 1 1 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 VDK71665.1 - 1.1e-25 89.5 3.1 1.1e-25 89.5 3.1 2.3 2 0 0 2 2 2 1 Cullin protein neddylation domain HbrB PF08539.11 VDK71665.1 - 0.0066 16.5 1.1 0.025 14.6 0.1 2.6 2 1 0 2 2 2 1 HbrB-like HTH_34 PF13601.6 VDK71665.1 - 0.019 15.1 0.1 0.06 13.5 0.1 1.9 1 0 0 1 1 1 0 Winged helix DNA-binding domain Ribosomal_L28 PF00830.19 VDK71665.1 - 0.16 12.2 0.0 1.1 9.5 0.0 2.3 2 0 0 2 2 2 0 Ribosomal L28 family Patatin PF01734.22 VDK71667.1 - 7.5e-14 52.4 3.2 2.4e-12 47.5 3.2 2.5 1 1 0 1 1 1 1 Patatin-like phospholipase DUF775 PF05603.12 VDK71667.1 - 0.017 14.7 0.1 0.028 14.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Activin_recp PF01064.23 VDK71673.1 - 0.0052 17.8 13.4 0.014 16.4 13.3 1.8 1 1 0 1 1 1 1 Activin types I and II receptor domain Toxin_TOLIP PF00087.21 VDK71673.1 - 0.025 14.8 1.2 0.025 14.8 1.2 2.2 1 1 1 2 2 2 0 Snake toxin and toxin-like protein QVR PF17064.5 VDK71673.1 - 0.049 13.9 8.6 0.062 13.6 8.6 1.2 1 0 0 1 1 1 0 Sleepless protein UPAR_LY6_2 PF16975.5 VDK71673.1 - 0.081 13.1 9.9 0.14 12.3 9.9 1.5 1 1 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 OATP PF03137.20 VDK71675.1 - 1.2e-151 505.8 15.2 1.7e-151 505.2 15.2 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 VDK71675.1 - 7.5e-21 74.4 29.1 2.3e-15 56.4 13.4 3.0 3 0 0 3 3 3 3 Major Facilitator Superfamily UNC-93 PF05978.16 VDK71675.1 - 0.0031 17.2 0.2 0.014 15.1 0.0 2.2 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF751 PF05421.11 VDK71675.1 - 8.8 7.1 9.3 0.94 10.2 0.6 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF751) Ribosomal_L6e PF01159.19 VDK71676.1 - 1.7e-35 121.9 0.0 3.5e-35 120.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 VDK71676.1 - 5e-10 39.5 8.4 5e-10 39.5 8.4 2.7 3 0 0 3 3 3 1 Ribosomal protein L6, N-terminal domain MRP-L51 PF10244.9 VDK71677.1 - 1e-32 112.2 1.0 1.6e-32 111.6 1.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit APOBEC3 PF18771.1 VDK71677.1 - 0.014 15.5 0.1 0.021 14.9 0.1 1.3 1 0 0 1 1 1 0 APOBEC3 Ribonuclease_3 PF00636.26 VDK71678.1 - 1.2e-57 193.0 0.0 6.1e-33 113.6 0.0 2.8 2 0 0 2 2 2 2 Ribonuclease III domain PAZ PF02170.22 VDK71678.1 - 1.5e-36 125.3 0.0 3.9e-36 123.9 0.0 1.7 1 0 0 1 1 1 1 PAZ domain Ribonucleas_3_3 PF14622.6 VDK71678.1 - 6.2e-26 91.0 0.0 1.3e-16 60.9 0.0 4.1 3 1 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.14 VDK71678.1 - 2.6e-25 88.4 0.1 1.2e-24 86.3 0.1 2.3 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.31 VDK71678.1 - 1.5e-14 54.2 0.1 3.1e-13 50.1 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK71678.1 - 1.4e-13 51.2 0.0 8.1e-13 48.7 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 VDK71678.1 - 1.4e-10 41.2 0.0 2.7e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase dsrm PF00035.26 VDK71678.1 - 0.067 13.9 0.0 3.3 8.5 0.0 2.9 2 0 0 2 2 2 0 Double-stranded RNA binding motif C6_DPF PF10170.9 VDK71680.1 - 8.7e-33 112.6 4.4 1.1e-32 112.2 4.4 1.1 1 0 0 1 1 1 1 Cysteine-rich domain zf-C4pol PF14260.6 VDK71680.1 - 0.034 14.6 1.2 0.034 14.6 1.2 2.6 2 1 1 3 3 3 0 C4-type zinc-finger of DNA polymerase delta RGS PF00615.19 VDK71682.1 - 8.4e-34 116.4 4.3 4.5e-19 68.9 0.4 3.0 3 0 0 3 3 3 2 Regulator of G protein signaling domain EGF_CA PF07645.15 VDK71684.1 - 9.9e-73 240.1 395.1 1.2e-10 41.5 8.7 27.4 23 3 4 27 27 27 14 Calcium-binding EGF domain EGF_3 PF12947.7 VDK71684.1 - 3.5e-58 193.5 401.8 1.4e-08 34.8 4.0 26.4 28 0 0 28 28 28 17 EGF domain cEGF PF12662.7 VDK71684.1 - 7.8e-36 121.6 239.8 1.5e-05 24.8 7.5 24.1 24 0 0 24 24 24 19 Complement Clr-like EGF-like EGF PF00008.27 VDK71684.1 - 1.6e-06 28.3 51.0 5.1e-05 23.5 6.9 26.5 28 1 0 28 28 28 16 EGF-like domain EGF_MSP1_1 PF12946.7 VDK71684.1 - 0.0021 18.0 5.5 0.0021 18.0 5.5 22.8 23 0 0 23 23 23 12 MSP1 EGF domain 1 hEGF PF12661.7 VDK71684.1 - 0.0036 17.9 5.2 0.0036 17.9 5.2 26.6 30 0 0 30 30 30 11 Human growth factor-like EGF Metallophos PF00149.28 VDK71711.1 - 1.8e-30 107.0 0.0 2.9e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK71711.1 - 0.011 16.2 0.1 0.072 13.5 0.2 2.3 3 0 0 3 3 3 0 Serine-threonine protein phosphatase N-terminal domain Arc PF03869.14 VDK71711.1 - 0.031 14.1 0.1 7.9 6.4 0.1 2.3 2 0 0 2 2 2 0 Arc-like DNA binding domain BDV_G PF06208.11 VDK71711.1 - 1.4 8.0 7.2 11 5.0 6.8 2.2 1 1 1 2 2 2 0 Borna disease virus G protein PAX PF00292.18 VDK71713.1 - 2.9e-55 185.6 1.2 3.6e-55 185.2 1.2 1.1 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 VDK71713.1 - 6.7e-06 25.8 0.1 1.6e-05 24.6 0.0 1.6 2 0 0 2 2 2 1 Homeodomain-like domain HTH_28 PF13518.6 VDK71713.1 - 0.00077 19.5 0.0 0.0031 17.6 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 VDK71713.1 - 0.0039 17.8 0.1 0.74 10.5 0.0 2.3 1 1 1 2 2 2 2 Homeodomain-like domain HTH_29 PF13551.6 VDK71713.1 - 0.0075 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix GerE PF00196.19 VDK71713.1 - 0.096 12.2 0.0 0.76 9.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family Peptidase_S9 PF00326.21 VDK71716.1 - 1.3e-29 103.2 0.0 2.3e-29 102.4 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 VDK71716.1 - 2.4e-05 23.7 0.0 0.0041 16.4 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK71716.1 - 2.6e-05 24.0 0.7 0.0073 16.0 0.9 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold BAAT_C PF08840.11 VDK71716.1 - 3.9e-05 23.7 0.0 8.5e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 VDK71716.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 VDK71716.1 - 0.0015 19.2 2.3 0.0019 18.9 0.7 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 VDK71716.1 - 0.022 14.3 0.0 0.07 12.7 0.0 1.8 1 1 0 1 1 1 0 Dienelactone hydrolase family Esterase PF00756.20 VDK71716.1 - 0.081 12.6 0.0 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 Putative esterase UPF0239 PF06783.11 VDK71717.1 - 0.28 11.4 0.6 0.63 10.3 0.6 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF2701 PF10857.8 VDK71717.1 - 6.7 6.8 10.2 7.6 6.6 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2701) Y_phosphatase PF00102.27 VDK71718.1 - 2.6e-78 262.9 1.6 4.1e-78 262.2 1.6 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase SH2 PF00017.24 VDK71718.1 - 2.6e-41 139.6 0.0 1.8e-20 72.8 0.0 2.7 2 0 0 2 2 2 2 SH2 domain DSPc PF00782.20 VDK71718.1 - 6e-06 26.1 0.1 1.9e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain SH2_2 PF14633.6 VDK71718.1 - 0.0031 17.0 0.0 0.13 11.7 0.0 2.5 2 0 0 2 2 2 1 SH2 domain PTPlike_phytase PF14566.6 VDK71718.1 - 0.0056 16.8 0.0 0.014 15.5 0.0 1.7 1 1 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 VDK71718.1 - 0.023 14.7 0.0 0.043 13.8 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Cbl_N3 PF02762.14 VDK71718.1 - 0.1 12.5 0.0 0.31 10.9 0.0 1.8 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain FmiP_Thoc5 PF09766.9 VDK71719.1 - 0.05 12.9 0.0 0.061 12.6 0.0 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 7TM_GPCR_Srw PF10324.9 VDK71721.1 - 5.5e-17 62.0 5.7 7.4e-17 61.6 5.7 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 VDK71721.1 - 2.1e-05 24.0 4.8 3.2e-05 23.4 4.8 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) PAP2 PF01569.21 VDK71723.1 - 7.2e-10 38.8 4.6 7.2e-10 38.8 4.6 2.1 2 0 0 2 2 2 1 PAP2 superfamily Rad17 PF03215.15 VDK71724.1 - 4.9e-22 78.8 0.1 9.5e-22 77.8 0.1 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 VDK71724.1 - 1.1e-07 32.3 0.0 2.6e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK71724.1 - 7.7e-05 23.0 0.0 0.00019 21.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 VDK71724.1 - 0.0001 22.8 0.1 0.00057 20.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 VDK71724.1 - 0.00019 20.6 0.0 0.00037 19.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 VDK71724.1 - 0.00091 19.6 0.0 0.0016 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain TsaE PF02367.17 VDK71724.1 - 0.0043 17.0 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 VDK71724.1 - 0.0044 17.2 0.0 0.013 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 VDK71724.1 - 0.0055 17.2 0.0 0.015 15.8 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_6 PF12774.7 VDK71724.1 - 0.01 14.8 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region RNA_helicase PF00910.22 VDK71724.1 - 0.018 15.4 0.0 0.043 14.2 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 VDK71724.1 - 0.021 14.3 0.0 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 VDK71724.1 - 0.029 14.4 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 VDK71724.1 - 0.038 14.5 2.3 0.13 12.7 2.3 2.2 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 VDK71724.1 - 0.039 13.7 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain dNK PF01712.19 VDK71724.1 - 0.042 13.7 0.0 0.095 12.5 0.0 1.6 1 1 0 1 1 1 0 Deoxynucleoside kinase NTPase_1 PF03266.15 VDK71724.1 - 0.045 13.7 0.0 0.089 12.7 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_assoc_2 PF16193.5 VDK71724.1 - 0.058 13.7 0.0 0.19 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain AAA_8 PF12780.7 VDK71724.1 - 0.06 12.7 0.0 2.7 7.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_14 PF13173.6 VDK71724.1 - 0.083 12.9 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 VDK71724.1 - 0.09 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 VDK71724.1 - 0.12 12.7 0.0 0.4 11.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain DUF87 PF01935.17 VDK71724.1 - 0.14 12.2 0.2 0.37 10.9 0.0 1.7 2 0 0 2 2 1 0 Helicase HerA, central domain cobW PF02492.19 VDK71724.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 VDK71724.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 VDK71724.1 - 0.22 11.2 0.0 0.54 10.0 0.0 1.6 2 0 0 2 2 1 0 AAA domain FHA PF00498.26 VDK71725.1 - 2.1e-13 50.4 0.3 5e-13 49.2 0.3 1.7 1 0 0 1 1 1 1 FHA domain PHD PF00628.29 VDK71725.1 - 0.029 14.2 10.7 0.067 13.1 10.7 1.6 1 0 0 1 1 1 0 PHD-finger Dam PF05869.11 VDK71725.1 - 0.055 13.0 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Pkinase PF00069.25 VDK71727.1 - 1.1e-67 228.1 0.0 2.1e-67 227.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK71727.1 - 3e-28 98.8 0.0 4.7e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK71727.1 - 4.6e-07 29.0 0.2 8.1e-06 24.9 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 VDK71727.1 - 0.00011 21.6 0.0 0.00027 20.3 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK71727.1 - 0.0096 15.3 0.0 0.032 13.6 0.0 2.0 2 1 0 2 2 2 1 Kinase-like Biopterin_H PF00351.21 VDK71729.1 - 5.6e-128 426.7 1.2 6.3e-128 426.5 1.2 1.0 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase Pkinase_Tyr PF07714.17 VDK71730.1 - 0.0024 17.2 0.0 0.0031 16.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK71730.1 - 0.015 14.7 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain Pkinase PF00069.25 VDK71731.1 - 2.6e-07 30.3 0.0 3.9e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK71731.1 - 0.0042 16.4 0.0 0.0049 16.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Beta-lactamase PF00144.24 VDK71732.1 - 2.2e-63 214.5 0.0 2.8e-63 214.2 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase EF-hand_4 PF12763.7 VDK71733.1 - 1.1e-36 125.0 0.0 1.8e-18 66.4 0.0 3.5 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 VDK71733.1 - 4.5e-12 44.6 0.1 0.029 13.9 0.0 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 VDK71733.1 - 1.7e-09 38.0 0.0 5.1e-05 23.6 0.0 3.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 VDK71733.1 - 5.1e-07 29.1 0.1 0.032 14.1 0.1 4.4 4 0 0 4 4 4 1 EF-hand domain EF-hand_5 PF13202.6 VDK71733.1 - 1.6e-06 27.3 2.5 0.011 15.2 0.3 2.9 2 0 0 2 2 2 2 EF hand SabA_adhesion PF18304.1 VDK71733.1 - 0.028 13.7 7.2 0.014 14.6 5.1 1.5 1 1 0 1 1 1 0 SabA N-terminal extracellular adhesion domain EF-hand_8 PF13833.6 VDK71733.1 - 0.04 13.8 0.5 23 4.9 0.0 3.7 3 1 1 4 4 4 0 EF-hand domain pair DUF3450 PF11932.8 VDK71733.1 - 0.048 13.0 24.5 1 8.6 13.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF2379 PF09543.10 VDK71733.1 - 0.053 13.7 5.7 0.029 14.6 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2379) Seryl_tRNA_N PF02403.22 VDK71733.1 - 0.11 12.7 29.7 1.5 9.1 10.7 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3584 PF12128.8 VDK71733.1 - 0.35 8.3 27.7 0.46 7.9 27.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 VDK71733.1 - 0.39 10.0 16.8 0.68 9.2 16.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 VDK71733.1 - 0.43 10.8 35.5 0.73 10.0 10.8 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ERM PF00769.19 VDK71733.1 - 0.48 10.2 37.7 0.19 11.5 15.6 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family FliJ PF02050.16 VDK71733.1 - 0.54 10.5 19.1 0.23 11.7 15.9 2.0 1 1 1 2 2 2 0 Flagellar FliJ protein TMF_TATA_bd PF12325.8 VDK71733.1 - 1.4 9.2 35.0 1.6 8.9 14.7 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding THOC7 PF05615.13 VDK71733.1 - 3.8 7.8 30.3 0.69 10.2 18.3 2.3 1 1 1 2 2 2 0 Tho complex subunit 7 COG2 PF06148.11 VDK71733.1 - 4.6 7.3 19.1 0.87 9.7 5.9 2.8 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Tropomyosin_1 PF12718.7 VDK71733.1 - 6.6 6.9 35.9 8.2 6.6 34.3 1.9 1 1 0 1 1 1 0 Tropomyosin like V_ATPase_I PF01496.19 VDK71733.1 - 7 4.4 12.1 11 3.8 12.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Gal-bind_lectin PF00337.22 VDK71739.1 - 3.1e-68 227.4 0.0 1.1e-34 118.8 0.0 2.0 2 0 0 2 2 2 2 Galactoside-binding lectin DUF4251 PF14059.6 VDK71739.1 - 0.11 12.4 0.0 0.58 10.1 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4251) Laminin_G_2 PF02210.24 VDK71739.1 - 0.13 12.9 0.0 0.69 10.5 0.0 2.2 3 0 0 3 3 3 0 Laminin G domain Robl_LC7 PF03259.17 VDK71742.1 - 2.1e-21 75.5 0.0 2.4e-21 75.3 0.0 1.0 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 VDK71742.1 - 0.00029 20.7 0.1 0.00038 20.3 0.1 1.2 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Sin3a_C PF16879.5 VDK71765.1 - 1e-49 169.8 2.7 1e-49 169.8 2.7 2.9 3 1 0 3 3 3 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 VDK71765.1 - 2e-36 124.0 0.4 5.4e-36 122.6 0.4 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor PAH PF02671.21 VDK71765.1 - 1.5e-24 85.9 4.3 8.8e-13 48.2 0.0 4.6 5 0 0 5 5 5 3 Paired amphipathic helix repeat SR-25 PF10500.9 VDK71766.1 - 0.28 10.8 12.6 0.4 10.2 12.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 VDK71766.1 - 6.8 4.6 13.7 8.8 4.3 13.7 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein zf-C4 PF00105.18 VDK71767.1 - 1.3e-32 112.1 12.6 2.2e-32 111.3 12.6 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK71768.1 - 5.8e-10 39.1 1.3 7.6e-10 38.7 1.3 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor TF_AP-2 PF03299.14 VDK71769.1 - 9.5e-63 211.7 0.0 2.1e-62 210.6 0.0 1.6 2 0 0 2 2 2 1 Transcription factor AP-2 MiAMP1 PF09117.10 VDK71769.1 - 0.095 12.9 2.2 3.4 8.0 0.2 2.8 1 1 1 2 2 2 0 MiAMP1 MARVEL PF01284.23 VDK71770.1 - 0.014 15.4 10.9 0.02 14.9 10.9 1.2 1 0 0 1 1 1 0 Membrane-associating domain IL17R_fnIII_D2 PF16578.5 VDK71771.1 - 0.087 13.4 0.2 0.26 11.8 0.1 1.9 1 1 0 1 1 1 0 Interleukin 17 receptor D YabA PF06156.13 VDK71771.1 - 3.5 8.3 22.0 2.2 9.0 4.3 3.9 2 2 1 3 3 3 0 Initiation control protein YabA DUF4140 PF13600.6 VDK71771.1 - 6.2 7.3 14.9 5.5 7.5 0.4 3.8 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DivIVA PF05103.13 VDK71771.1 - 8.8 6.4 16.2 0.21 11.6 8.4 2.2 3 0 0 3 3 3 0 DivIVA protein DASH_Spc19 PF08287.11 VDK71771.1 - 9.7 6.1 16.8 0.15 12.0 8.6 2.1 2 1 1 3 3 3 0 Spc19 tRNA-synt_1 PF00133.22 VDK71772.1 - 3.7e-221 735.5 0.2 4.9e-221 735.1 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 VDK71772.1 - 2.2e-24 86.1 0.0 5.8e-24 84.8 0.0 1.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 VDK71772.1 - 6.6e-11 41.6 0.7 0.0041 15.9 0.1 3.6 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 VDK71772.1 - 0.0064 15.9 0.0 0.069 12.5 0.0 2.5 2 1 1 3 3 3 1 tRNA synthetases class I (C) catalytic domain WD40 PF00400.32 VDK71773.1 - 2.4e-24 85.1 5.7 7.9e-05 23.4 0.1 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK71773.1 - 4.4e-10 39.7 0.0 0.0007 19.8 0.0 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 VDK71773.1 - 0.0027 17.3 0.2 0.0056 16.3 0.2 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain WD40_like PF17005.5 VDK71773.1 - 0.03 13.7 0.0 3.1 7.1 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain GNAT_acetyltr_2 PF13718.6 VDK71774.1 - 4.9e-90 300.9 0.0 1.6e-89 299.2 0.0 1.9 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 VDK71774.1 - 2.6e-69 233.5 3.0 4.3e-69 232.8 3.0 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 VDK71774.1 - 3.8e-61 206.0 0.0 8.8e-61 204.8 0.0 1.7 1 0 0 1 1 1 1 Helicase DUF1726 PF08351.11 VDK71774.1 - 5.6e-33 112.7 0.0 1.4e-32 111.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) Acetyltransf_1 PF00583.25 VDK71774.1 - 0.00043 20.5 0.0 0.0075 16.5 0.0 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family AAA_30 PF13604.6 VDK71774.1 - 0.0014 18.4 0.0 1.2 8.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain Acetyltransf_7 PF13508.7 VDK71774.1 - 0.0045 17.4 0.0 0.022 15.2 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain zf-Tim10_DDP PF02953.15 VDK71775.1 - 2.2e-20 72.0 2.5 4.2e-20 71.2 2.5 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger zf-RanBP PF00641.18 VDK71775.1 - 2.2e-07 30.1 2.7 3.7e-07 29.3 2.7 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 VDK71775.1 - 3.2e-07 30.1 0.0 1.1e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) C1_2 PF03107.16 VDK71775.1 - 0.077 13.3 1.4 0.2 12.0 1.4 1.6 1 0 0 1 1 1 0 C1 domain T3SS_needle_F PF09392.10 VDK71775.1 - 0.28 11.4 1.7 0.7 10.1 1.7 1.6 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Sporozoite_P67 PF05642.11 VDK71775.1 - 1.1 7.3 7.7 2 6.4 7.7 1.6 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pepsin-I3 PF06394.13 VDK71776.1 - 0.045 13.9 0.0 0.069 13.4 0.0 1.3 1 0 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain HTH_OrfB_IS605 PF12323.8 VDK71776.1 - 0.19 11.3 0.4 5.5 6.6 0.1 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain Pepsin-I3 PF06394.13 VDK71777.1 - 0.00061 19.9 0.1 0.001 19.2 0.1 1.3 1 0 0 1 1 1 1 Pepsin inhibitor-3-like repeated domain CRISPR_Cse1 PF09481.10 VDK71777.1 - 0.036 13.2 0.0 0.04 13.0 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) zf-C2H2 PF00096.26 VDK71778.1 - 8.3e-21 73.2 28.8 4.8e-05 23.6 0.7 5.8 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK71778.1 - 1.6e-16 59.5 34.8 0.00098 19.8 0.9 6.4 7 0 0 7 7 5 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK71778.1 - 2.2e-10 40.5 29.2 9.1e-05 22.7 0.2 6.7 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 VDK71778.1 - 3.9e-06 26.7 27.7 0.01 15.8 0.7 5.4 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 VDK71778.1 - 5.3e-06 26.1 21.9 0.31 10.8 0.8 6.1 5 1 1 6 6 6 3 zinc-finger C2H2-type HypA PF01155.19 VDK71778.1 - 9.3e-05 22.4 7.6 0.015 15.3 0.1 3.3 2 1 1 3 3 3 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_3rep PF18868.1 VDK71778.1 - 0.00011 22.9 4.8 0.049 14.3 2.1 2.8 2 1 0 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 VDK71778.1 - 0.0015 18.8 16.3 0.23 11.8 0.1 5.1 5 0 0 5 5 5 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 VDK71778.1 - 0.003 17.6 17.6 0.28 11.2 0.3 4.7 3 1 1 4 4 4 2 BED zinc finger Zn-ribbon_8 PF09723.10 VDK71778.1 - 0.022 14.9 14.4 0.13 12.4 0.5 4.1 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2HC_2 PF13913.6 VDK71778.1 - 0.026 14.4 20.5 0.29 11.1 1.5 5.4 5 0 0 5 5 5 0 zinc-finger of a C2HC-type zinc_ribbon_15 PF17032.5 VDK71778.1 - 0.032 15.0 10.4 1.2 9.9 1.2 3.6 2 1 1 3 3 3 0 zinc-ribbon family ARS2 PF04959.13 VDK71778.1 - 0.046 14.1 0.7 0.046 14.1 0.7 2.4 1 1 2 3 3 3 0 Arsenite-resistance protein 2 ADK_lid PF05191.14 VDK71778.1 - 0.054 13.5 15.4 0.15 12.0 0.6 4.0 4 1 0 4 4 4 0 Adenylate kinase, active site lid zf-C2H2_2 PF12756.7 VDK71778.1 - 0.14 12.5 20.1 12 6.2 0.2 5.0 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 VDK71778.1 - 0.18 12.1 17.7 4.3 7.7 1.9 4.1 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 VDK71778.1 - 0.37 10.4 12.3 5 6.8 0.0 4.9 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger DUF3797 PF12677.7 VDK71778.1 - 0.4 10.6 3.4 3.7 7.5 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) DUF2256 PF10013.9 VDK71778.1 - 0.43 10.7 11.7 21 5.3 0.0 5.0 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) XPA_N PF01286.18 VDK71778.1 - 0.78 9.8 15.4 1.7 8.8 0.0 5.2 6 0 0 6 6 5 0 XPA protein N-terminal zf-LYAR PF08790.11 VDK71778.1 - 2.1 8.3 8.1 11 6.0 0.0 3.8 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger FYVE PF01363.21 VDK71778.1 - 2.2 8.5 20.1 8.7 6.6 6.0 4.0 3 1 1 4 4 3 0 FYVE zinc finger zf-AN1 PF01428.16 VDK71778.1 - 3.4 7.9 13.3 73 3.7 0.3 5.0 5 0 0 5 5 5 0 AN1-like Zinc finger Elf1 PF05129.13 VDK71778.1 - 7.7 6.6 11.3 22 5.2 1.0 3.8 2 1 1 3 3 3 0 Transcription elongation factor Elf1 like CpXC PF14353.6 VDK71778.1 - 7.7 6.6 16.1 44 4.1 0.6 4.9 1 1 2 4 4 4 0 CpXC protein Activin_recp PF01064.23 VDK71780.1 - 0.0074 17.4 11.8 0.0093 17.0 11.8 1.2 1 0 0 1 1 1 1 Activin types I and II receptor domain DnaJ_C PF01556.18 VDK71785.1 - 4.7e-40 137.1 0.2 6.7e-40 136.6 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 VDK71785.1 - 1.4e-23 82.7 0.7 2.3e-23 82.1 0.7 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 VDK71785.1 - 1.3e-14 54.3 16.7 2.7e-14 53.3 16.7 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 VDK71785.1 - 0.018 15.0 16.0 0.16 12.0 3.9 2.8 2 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 VDK71785.1 - 0.031 14.3 6.1 1.4 8.9 1.2 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Cytochrom_c3_2 PF14537.6 VDK71785.1 - 0.13 12.8 6.9 1.9 9.0 1.8 2.5 2 0 0 2 2 2 0 Cytochrome c3 Cytochrome_C7 PF14522.6 VDK71785.1 - 1.7 8.7 9.3 81 3.3 9.2 2.4 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c zinc-ribbons_6 PF07191.12 VDK71785.1 - 2.9 7.9 10.2 12 5.9 2.6 2.4 1 1 1 2 2 2 0 zinc-ribbons Cytochrome_CBB3 PF13442.6 VDK71785.1 - 6.8 7.1 6.5 3.8 7.9 3.5 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III GCFC PF07842.12 VDK71787.1 - 5.3e-13 49.2 0.2 5.8e-11 42.5 0.2 2.8 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein DUF3137 PF11335.8 VDK71787.1 - 0.042 13.8 0.8 0.11 12.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3137) DUF4733 PF15878.5 VDK71787.1 - 0.09 13.3 0.1 8.2 7.0 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4733) Tubulin PF00091.25 VDK71789.1 - 3.3e-68 229.8 0.0 4.4e-68 229.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK71789.1 - 7.6e-49 165.1 0.0 1.2e-48 164.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK71789.1 - 0.00014 21.6 0.0 0.00028 20.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Synaphin PF05835.12 VDK71790.1 - 0.0022 18.3 4.4 0.0029 17.9 4.4 1.2 1 0 0 1 1 1 1 Synaphin protein PHC2_SAM_assoc PF16616.5 VDK71790.1 - 0.51 11.2 4.2 0.6 10.9 4.2 1.1 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 ubiquitin PF00240.23 VDK71791.1 - 4.1e-06 26.5 0.3 2.6e-05 23.9 0.3 1.9 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 VDK71791.1 - 5.9e-05 23.4 0.2 0.00031 21.1 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 VDK71791.1 - 0.0097 15.7 0.2 0.058 13.2 0.2 1.9 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 VDK71791.1 - 0.017 15.2 0.2 0.087 12.9 0.2 1.9 1 1 0 1 1 1 0 Ubiquitin-like domain PI3K_rbd PF00794.18 VDK71791.1 - 0.044 13.9 0.0 0.053 13.7 0.0 1.2 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain V-ATPase_G PF03179.15 VDK71792.1 - 5.8e-37 126.4 20.9 6.8e-37 126.2 20.9 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3348 PF11828.8 VDK71792.1 - 0.034 13.8 6.3 0.042 13.5 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) Apolipoprotein PF01442.18 VDK71792.1 - 0.072 13.0 14.4 0.08 12.8 14.4 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DDRGK PF09756.9 VDK71792.1 - 0.13 11.8 19.5 0.17 11.4 19.5 1.2 1 0 0 1 1 1 0 DDRGK domain V-ATPase_G_2 PF16999.5 VDK71792.1 - 0.16 12.4 18.3 0.23 11.9 18.3 1.1 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DUF2827 PF10933.8 VDK71792.1 - 0.32 9.6 3.1 0.45 9.1 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2827) RabGAP-TBC PF00566.18 VDK71792.1 - 0.52 9.9 5.7 0.75 9.4 5.7 1.3 1 1 0 1 1 1 0 Rab-GTPase-TBC domain FdhE PF04216.12 VDK71792.1 - 0.86 9.4 6.2 1 9.2 6.2 1.0 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation DUF4407 PF14362.6 VDK71792.1 - 1.2 8.4 11.4 1.4 8.2 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3552 PF12072.8 VDK71792.1 - 1.6 8.1 25.7 7.3 6.0 25.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Exonuc_VII_L PF02601.15 VDK71792.1 - 2.6 7.6 10.5 2.9 7.4 10.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF883 PF05957.13 VDK71792.1 - 5.8 7.6 11.6 3.9 8.1 7.8 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) RRF PF01765.19 VDK71792.1 - 6.3 6.7 17.0 8.6 6.3 17.0 1.2 1 0 0 1 1 1 0 Ribosome recycling factor XRCC1_N PF01834.16 VDK71793.1 - 0.068 13.2 0.5 0.1 12.6 0.5 1.1 1 0 0 1 1 1 0 XRCC1 N terminal domain Homeodomain PF00046.29 VDK71815.1 - 4.3e-19 68.1 7.3 7.2e-19 67.4 7.3 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK71815.1 - 0.0069 16.3 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Ion_trans_2 PF07885.16 VDK71816.1 - 5.8e-24 83.9 20.2 3.9e-16 58.8 5.2 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK71816.1 - 0.07 12.4 6.4 0.034 13.4 1.4 2.1 2 0 0 2 2 2 0 Ion transport protein NCU-G1 PF15065.6 VDK71816.1 - 0.11 11.5 1.5 0.24 10.3 1.5 1.5 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 Peptidase_M28 PF04389.17 VDK71817.1 - 7.6e-41 140.0 0.0 1.1e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 AbiJ_NTD3 PF18860.1 VDK71817.1 - 0.0022 17.6 0.0 0.0038 16.8 0.0 1.4 1 0 0 1 1 1 1 AbiJ N-terminal domain 3 Nicastrin PF05450.15 VDK71817.1 - 0.031 13.7 0.0 0.045 13.2 0.0 1.3 1 0 0 1 1 1 0 Nicastrin PriCT_2 PF08707.11 VDK71817.1 - 0.066 13.6 1.0 17 5.8 0.1 2.7 2 0 0 2 2 2 0 Primase C terminal 2 (PriCT-2) NIF PF03031.18 VDK71819.1 - 6.2e-34 117.0 0.9 8.8e-34 116.5 0.9 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BLI1 PF17324.2 VDK71819.1 - 0.13 13.0 0.1 0.34 11.6 0.1 1.7 1 0 0 1 1 1 0 BLOC-1 interactor 1 Occludin_ELL PF07303.13 VDK71819.1 - 0.17 12.6 2.3 0.62 10.8 0.2 2.2 2 0 0 2 2 2 0 Occludin homology domain Metallophos PF00149.28 VDK71823.1 - 6.2e-33 115.0 0.0 8.7e-33 114.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF236 PF03057.14 VDK71823.1 - 1.1e-27 95.6 0.2 2.3e-10 40.2 0.0 3.4 3 0 0 3 3 3 3 DUF236 repeat STPPase_N PF16891.5 VDK71823.1 - 9.5e-15 54.8 0.2 3.1e-14 53.1 0.1 1.9 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain TAF PF02969.17 VDK71823.1 - 0.024 14.8 0.0 7 6.9 0.0 3.0 3 0 0 3 3 3 0 TATA box binding protein associated factor (TAF) Pkinase PF00069.25 VDK71824.1 - 2.2e-86 289.5 0.0 1.1e-51 175.7 0.0 2.6 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK71824.1 - 6.5e-40 137.0 0.1 2.9e-25 89.0 0.0 2.5 2 1 1 3 3 3 2 Protein tyrosine kinase PH PF00169.29 VDK71824.1 - 3.1e-15 56.6 0.0 9.2e-15 55.0 0.0 1.9 1 0 0 1 1 1 1 PH domain Pkinase_C PF00433.24 VDK71824.1 - 5.8e-09 36.5 2.5 1.7e-08 35.0 2.5 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 VDK71824.1 - 1.1e-06 28.2 0.0 1.9e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PH_11 PF15413.6 VDK71824.1 - 0.0079 16.6 0.4 0.97 9.9 0.1 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain FTA2 PF13095.6 VDK71824.1 - 0.036 13.7 0.4 0.78 9.3 0.1 2.6 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 VDK71824.1 - 0.066 12.1 0.8 0.46 9.4 0.1 2.0 2 0 0 2 2 2 0 Haspin like kinase domain SNAP-25 PF00835.19 VDK71825.1 - 2.7e-21 75.6 0.2 5.9e-21 74.5 0.2 1.6 1 0 0 1 1 1 1 SNAP-25 family SNARE PF05739.19 VDK71825.1 - 0.15 12.0 2.5 36 4.4 0.2 3.3 3 0 0 3 3 3 0 SNARE domain V-SNARE_C PF12352.8 VDK71825.1 - 0.18 12.1 6.9 0.33 11.2 0.3 2.8 2 1 1 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus STAG PF08514.11 VDK71825.1 - 0.27 11.2 2.6 0.21 11.5 0.9 1.7 2 0 0 2 2 2 0 STAG domain DUF5089 PF17002.5 VDK71825.1 - 0.33 10.8 10.8 0.65 9.8 0.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5089) DUF16 PF01519.16 VDK71825.1 - 0.38 11.2 5.8 4.1 7.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.12 VDK71825.1 - 0.91 9.6 8.4 8.2 6.5 3.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 VDK71825.1 - 1.1 9.8 7.0 0.73 10.3 1.6 2.5 2 1 0 2 2 2 0 Snapin/Pallidin DUF948 PF06103.11 VDK71825.1 - 2.5 8.4 7.3 9.6 6.5 1.6 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 VDK71825.1 - 2.8 8.0 10.6 6.2 6.8 5.0 2.8 2 1 1 3 3 3 0 Laminin Domain II SOAR PF16533.5 VDK71825.1 - 3.8 7.5 7.5 4.7 7.3 0.0 3.2 3 1 1 4 4 4 0 STIM1 Orai1-activating region TolA_bind_tri PF16331.5 VDK71825.1 - 7.9 6.6 12.2 0.29 11.2 3.7 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation Jnk-SapK_ap_N PF09744.9 VDK71825.1 - 8.3 6.6 12.9 1.4 9.1 4.6 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 TFIIB PF00382.19 VDK71827.1 - 2e-42 143.1 7.9 2.1e-21 75.8 1.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 VDK71827.1 - 2.8e-13 49.2 0.1 4.6e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 VDK71827.1 - 5.8e-06 26.1 0.1 0.00022 20.9 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 VDK71827.1 - 0.021 14.9 0.9 2.4 8.3 0.0 2.4 1 1 1 2 2 2 0 Cyclin, C-terminal domain MarR_2 PF12802.7 VDK71827.1 - 0.028 14.3 0.3 12 5.9 0.1 2.7 3 0 0 3 3 3 0 MarR family RB_B PF01857.20 VDK71827.1 - 0.17 11.9 0.0 0.5 10.4 0.0 1.6 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain Mcl1_mid PF12341.8 VDK71829.1 - 6.8e-65 219.3 0.3 5.5e-64 216.4 0.0 2.4 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 VDK71829.1 - 1.2e-08 35.4 12.5 0.15 13.0 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK71829.1 - 8.6e-06 26.0 0.2 3.6 7.9 0.0 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK71829.1 - 0.0012 18.2 0.1 0.0028 17.0 0.1 1.5 1 0 0 1 1 1 1 WD40-like domain Hira PF07569.11 VDK71829.1 - 0.9 9.2 4.9 17 5.0 0.0 2.9 3 0 0 3 3 3 0 TUP1-like enhancer of split EF1G PF00647.19 VDK71831.1 - 1.1e-50 170.1 0.5 2.7e-50 168.9 0.5 1.7 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 VDK71831.1 - 4.7e-09 36.3 0.5 1.3e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 VDK71831.1 - 6.5e-05 22.9 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 VDK71831.1 - 0.0066 16.6 0.0 0.024 14.8 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain AP3D1 PF06375.11 VDK71831.1 - 0.011 16.0 6.3 0.016 15.4 6.3 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Josephin PF02099.17 VDK71831.1 - 0.015 15.4 0.0 0.035 14.2 0.0 1.6 1 1 0 1 1 1 0 Josephin DUF4820 PF16091.5 VDK71831.1 - 0.019 14.3 1.0 0.031 13.7 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) GST_N PF02798.20 VDK71831.1 - 0.15 12.4 0.0 0.83 10.0 0.0 2.4 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain U79_P34 PF03064.16 VDK71831.1 - 0.83 9.0 9.3 1.3 8.3 9.3 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 NARP1 PF12569.8 VDK71831.1 - 2.8 6.8 10.3 4.3 6.1 10.3 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Peptidase_S49_N PF08496.10 VDK71831.1 - 7.8 6.5 7.9 13 5.8 7.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pkinase_Tyr PF07714.17 VDK71832.1 - 4.2e-82 275.3 0.0 6e-82 274.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK71832.1 - 3.8e-33 115.0 0.0 5.9e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain fn3 PF00041.21 VDK71832.1 - 1.5e-11 44.4 8.3 0.017 15.4 0.0 6.3 6 1 0 6 6 6 3 Fibronectin type III domain fn3_2 PF16893.5 VDK71832.1 - 0.046 13.9 0.0 0.43 10.8 0.0 2.5 2 0 0 2 2 2 0 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK71832.1 - 0.19 12.3 2.1 25 5.5 0.0 3.3 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Cornichon PF03311.14 VDK71834.1 - 1.6e-42 144.7 6.5 2e-42 144.3 6.5 1.0 1 0 0 1 1 1 1 Cornichon protein DHHC PF01529.20 VDK71834.1 - 0.75 9.9 12.9 0.2 11.7 7.7 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase SepRS_C PF18006.1 VDK71837.1 - 0.13 12.3 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 O-phosphoseryl-tRNA synthetase C-terminal domain BRCT PF00533.26 VDK71839.1 - 8e-27 93.4 0.1 1.4e-06 28.6 0.0 4.7 4 1 1 5 5 5 4 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 VDK71839.1 - 1.3e-23 82.7 1.4 5.6e-12 45.4 0.1 3.6 3 0 0 3 3 3 3 twin BRCT domain BRCT_2 PF16589.5 VDK71839.1 - 6.4e-16 58.5 0.0 3.9e-05 24.0 0.0 4.5 5 0 0 5 5 5 3 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 VDK71839.1 - 4.7e-10 39.2 0.0 5.3e-08 32.6 0.0 3.0 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 VDK71839.1 - 7.9e-05 22.9 0.1 0.52 10.6 0.0 3.8 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain WD40 PF00400.32 VDK71841.1 - 2.9e-39 132.3 20.5 9.5e-08 32.6 0.7 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK71841.1 - 1.3e-12 47.9 0.1 0.042 14.1 0.0 5.1 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK71841.1 - 2.7e-06 27.4 0.0 0.0039 17.1 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 VDK71841.1 - 3.8e-06 26.5 0.0 0.42 9.9 0.0 3.4 2 2 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 VDK71841.1 - 0.00025 20.1 0.0 0.32 9.9 0.0 3.1 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein RraA-like PF03737.15 VDK71841.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Aldolase/RraA Rsm22 PF09243.10 VDK71842.1 - 3.3e-36 125.0 0.0 3.6e-19 69.1 0.0 2.2 1 1 1 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_25 PF13649.6 VDK71842.1 - 0.0028 18.3 0.0 0.085 13.6 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK71842.1 - 0.009 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK71842.1 - 0.022 14.5 0.0 0.12 12.1 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain Glyco_transf_20 PF00982.21 VDK71872.1 - 5.7e-77 259.4 0.3 3.9e-75 253.3 0.6 2.3 2 1 0 2 2 2 2 Glycosyltransferase family 20 T6PP_N PF18572.1 VDK71872.1 - 2e-34 117.4 0.2 5.9e-34 115.9 0.2 1.9 1 0 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Hydrolase_3 PF08282.12 VDK71872.1 - 0.0039 17.0 0.0 0.0095 15.7 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase EF-hand_6 PF13405.6 VDK71873.1 - 1.2e-12 46.7 2.3 7.9e-06 25.4 0.4 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 VDK71873.1 - 1.3e-12 47.9 0.3 1.4e-06 28.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK71873.1 - 1.7e-10 39.7 5.0 1.7e-05 24.0 1.2 3.6 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 VDK71873.1 - 1.4e-07 30.7 5.3 0.00058 19.2 1.3 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 VDK71873.1 - 2e-06 27.5 1.0 0.025 14.4 0.2 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 VDK71873.1 - 0.0019 18.5 0.0 2.7 8.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 VDK71873.1 - 0.0048 17.2 0.6 0.018 15.4 0.4 1.9 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 VDK71873.1 - 0.0049 17.7 0.0 2.3 9.1 0.0 2.1 1 1 1 2 2 2 2 EF-hand domain POTRA PF07244.15 VDK71873.1 - 0.034 14.7 0.7 1.2 9.8 0.0 2.5 3 0 0 3 3 3 0 Surface antigen variable number repeat UPF0154 PF03672.13 VDK71873.1 - 0.044 13.8 0.5 0.72 9.9 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) SurA_N_2 PF13623.6 VDK71873.1 - 0.061 13.2 0.6 3.1 7.6 0.1 2.3 2 0 0 2 2 2 0 SurA N-terminal domain Adenine_glyco PF03352.13 VDK71873.1 - 0.11 12.2 0.1 6.3 6.5 0.0 2.1 2 0 0 2 2 2 0 Methyladenine glycosylase Calsequestrin PF01216.17 VDK71876.1 - 3.7e-59 200.7 13.0 4.2e-59 200.5 13.0 1.0 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_6 PF13848.6 VDK71876.1 - 3.4e-12 46.7 0.3 8.8e-10 38.8 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain DUF812 PF05667.11 VDK71877.1 - 6.8e-59 200.3 32.4 1.7e-34 119.7 31.9 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF812) DivIC PF04977.15 VDK71877.1 - 1.2 8.9 19.3 1.1 9.0 0.3 4.5 3 1 1 4 4 4 0 Septum formation initiator MMR_HSR1 PF01926.23 VDK71877.1 - 5.5 7.1 6.5 4.3e+02 1.0 6.5 3.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase LIM_bind PF01803.16 VDK71883.1 - 6.4e-29 101.2 4.1 6.4e-29 101.2 4.1 3.1 2 2 0 2 2 2 1 LIM-domain binding protein LID PF17916.1 VDK71883.1 - 5.7e-19 67.4 7.0 1.1e-18 66.5 7.0 1.5 1 0 0 1 1 1 1 LIM interaction domain (LID) Erv26 PF04148.13 VDK71883.1 - 0.12 12.2 0.8 0.21 11.4 0.0 1.7 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 Neur_chan_LBD PF02931.23 VDK71885.1 - 1.5e-11 44.2 0.7 4.7e-11 42.6 0.7 1.7 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain MFS_1 PF07690.16 VDK71886.1 - 3.2e-31 108.6 27.0 1.2e-25 90.2 18.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 VDK71886.1 - 0.00021 20.7 21.5 0.017 14.4 8.6 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Histone PF00125.24 VDK71887.1 - 2.6e-32 111.9 0.4 1.8e-31 109.2 0.0 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Acyltransferase PF01553.21 VDK71887.1 - 2.3e-16 59.7 0.0 5.1e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase CENP-S PF15630.6 VDK71887.1 - 0.017 15.5 0.0 0.062 13.7 0.0 1.9 1 0 0 1 1 1 0 CENP-S protein Hormone_recep PF00104.30 VDK71888.1 - 3.3e-22 79.1 0.4 3.3e-22 79.1 0.4 1.6 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 VDK71888.1 - 2.5e-20 72.7 18.1 4.3e-13 49.5 7.1 3.2 4 0 0 4 4 4 2 Zinc finger, C4 type (two domains) Vac14_Fab1_bd PF12755.7 VDK71889.1 - 0.003 18.1 0.2 0.017 15.7 0.2 2.4 1 0 0 1 1 1 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 VDK71889.1 - 0.038 14.2 0.1 0.34 11.3 0.1 2.9 1 0 0 1 1 1 0 HEAT repeat PUB PF09409.10 VDK71889.1 - 0.12 12.4 0.1 0.44 10.5 0.1 2.0 1 0 0 1 1 1 0 PUB domain EF-hand_7 PF13499.6 VDK71890.1 - 1e-05 25.9 0.6 0.05 14.1 0.0 4.1 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 VDK71890.1 - 0.0015 18.3 0.0 0.0073 16.1 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK71890.1 - 0.006 16.4 0.0 13 6.0 0.1 3.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 VDK71890.1 - 0.0075 15.7 0.0 1.2 8.9 0.1 2.8 2 0 0 2 2 2 1 EF hand FAD-SLDH PF12318.8 VDK71890.1 - 0.096 12.8 0.0 0.096 12.8 0.0 3.2 3 0 0 3 3 3 0 Membrane bound FAD containing D-sorbitol dehydrogenase HALZ PF02183.18 VDK71890.1 - 0.25 11.6 18.6 0.52 10.6 0.3 5.7 5 0 0 5 5 5 0 Homeobox associated leucine zipper DUF2939 PF11159.8 VDK71890.1 - 0.65 10.4 3.5 11 6.5 0.9 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2939) DENN PF02141.21 VDK71891.1 - 1.5e-23 83.7 0.8 3.5e-23 82.5 0.8 1.6 1 1 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 VDK71891.1 - 5.2e-05 23.9 0.2 0.00011 22.9 0.2 1.6 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 VDK71891.1 - 0.0094 15.9 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 VDK71891.1 - 0.02 14.8 0.3 0.054 13.5 0.0 1.8 2 0 0 2 2 2 0 Stabilization of polarity axis NCBP3 PF10309.9 VDK71918.1 - 0.0098 15.7 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 zinc_ribbon_16 PF17034.5 VDK71922.1 - 1.4e-08 35.0 20.5 1.2e-07 32.0 20.5 2.5 1 1 0 1 1 1 1 Zinc-ribbon like family Ion_trans_2 PF07885.16 VDK71923.1 - 3.8e-30 103.7 25.1 2.2e-16 59.6 2.6 2.7 3 0 0 3 3 3 2 Ion channel DUF4175 PF13779.6 VDK71923.1 - 0.028 12.4 0.1 1.3 6.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) DUF5305 PF17231.2 VDK71923.1 - 0.053 12.9 0.9 0.34 10.3 0.0 2.7 4 0 0 4 4 4 0 Family of unknown function (DUF5305) CrgA PF06781.12 VDK71923.1 - 0.18 11.9 3.7 13 5.9 1.1 2.9 1 1 1 2 2 2 0 Cell division protein CrgA DUF2207 PF09972.9 VDK71923.1 - 0.26 10.0 5.9 0.045 12.5 0.5 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) CDC13_N PF16853.5 VDK71924.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus Myotub-related PF06602.14 VDK71926.1 - 6.4e-118 393.7 0.0 8.1e-118 393.4 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain 3-PAP PF12578.8 VDK71926.1 - 0.11 12.3 1.0 0.24 11.2 1.0 1.5 1 0 0 1 1 1 0 Myotubularin-associated protein NAGidase PF07555.13 VDK71927.1 - 8.1e-78 261.7 0.0 1.3e-77 261.1 0.0 1.3 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase EIID-AGA PF03613.14 VDK71927.1 - 0.077 12.2 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 PTS system mannose/fructose/sorbose family IID component RRM_1 PF00076.22 VDK71928.1 - 2.3e-38 129.8 0.0 3.6e-20 71.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK71928.1 - 1.3e-08 34.6 0.0 1.2e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 VDK71928.1 - 3.3e-05 23.9 0.1 0.59 10.3 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif Nup35_RRM PF05172.13 VDK71928.1 - 4.5e-05 23.4 0.2 0.078 12.9 0.1 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 VDK71928.1 - 0.00052 19.6 0.0 0.0055 16.3 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 VDK71928.1 - 0.0035 17.4 0.3 0.011 15.7 0.1 1.9 2 0 0 2 2 2 1 Limkain b1 Nup35_RRM_2 PF14605.6 VDK71928.1 - 0.015 15.3 0.1 3.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Exotox-A_cataly PF09009.10 VDK71928.1 - 0.035 13.9 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Exotoxin A catalytic DUF4523 PF15023.6 VDK71928.1 - 0.068 13.0 0.1 0.24 11.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) RRM_3 PF08777.11 VDK71928.1 - 0.078 13.0 0.0 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif GpcrRhopsn4 PF10192.9 VDK71930.1 - 1.7e-43 148.9 18.1 4.6e-23 81.9 4.1 2.2 1 1 1 2 2 2 2 Rhodopsin-like GPCR transmembrane domain Lung_7-TM_R PF06814.13 VDK71930.1 - 4.1e-10 39.4 2.3 4.1e-10 39.4 2.3 2.0 2 1 0 2 2 2 1 Lung seven transmembrane receptor CAP PF00188.26 VDK71931.1 - 2.4e-15 57.5 0.6 3.9e-15 56.8 0.0 1.7 2 0 0 2 2 2 1 Cysteine-rich secretory protein family NADH_4Fe-4S PF10589.9 VDK71931.1 - 0.17 12.0 3.0 0.17 11.9 1.0 2.3 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region PHD PF00628.29 VDK71933.1 - 3.5e-10 39.6 6.3 2.8e-08 33.5 2.5 2.8 2 0 0 2 2 2 2 PHD-finger PHD_2 PF13831.6 VDK71933.1 - 0.0076 15.8 2.1 0.0076 15.8 2.1 2.5 2 0 0 2 2 2 1 PHD-finger YhzD PF14120.6 VDK71933.1 - 1.3 9.1 0.0 1.3 9.1 0.0 3.4 3 0 0 3 3 3 0 YhzD-like protein Bromo_TP PF07524.13 VDK71934.1 - 5.2e-11 42.4 0.0 1.2e-10 41.3 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 VDK71934.1 - 0.0011 19.0 0.4 0.0037 17.3 0.0 2.0 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 VDK71934.1 - 0.02 15.3 0.1 0.073 13.5 0.1 2.1 1 0 0 1 1 1 0 CENP-S protein CENP-T_C PF15511.6 VDK71934.1 - 0.039 14.1 2.0 0.086 13.0 0.1 2.6 3 0 0 3 3 3 0 Centromere kinetochore component CENP-T histone fold Glyco_hydro_31 PF01055.26 VDK71935.1 - 3.6e-117 392.3 2.3 1.1e-116 390.7 2.3 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 VDK71935.1 - 4e-12 46.3 0.0 1e-11 45.0 0.0 1.7 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Trefoil PF00088.18 VDK71935.1 - 2.8e-08 33.5 1.6 2.8e-08 33.5 1.6 1.8 2 0 0 2 2 2 1 Trefoil (P-type) domain Gal_mutarotas_2 PF13802.6 VDK71935.1 - 3.2e-08 33.8 4.2 4.8e-08 33.2 0.3 3.1 3 0 0 3 3 3 1 Galactose mutarotase-like Transposase_1 PF01359.18 VDK71935.1 - 0.17 11.8 0.4 0.42 10.5 0.4 1.6 1 0 0 1 1 1 0 Transposase (partial DDE domain) NUDIX_2 PF13869.6 VDK71936.1 - 1.3e-59 200.9 0.0 1.6e-59 200.7 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase UNC-93 PF05978.16 VDK71937.1 - 8.5e-49 165.3 18.1 8.5e-49 165.3 18.1 3.3 2 2 1 3 3 3 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 VDK71937.1 - 3.9e-19 68.8 30.3 3.9e-19 68.8 30.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C4 PF00105.18 VDK71938.1 - 6.7e-32 109.8 15.2 1.3e-31 108.9 15.2 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK71938.1 - 4e-05 23.3 0.4 4e-05 23.3 0.4 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor Pkinase PF00069.25 VDK71940.1 - 4.1e-59 200.1 0.0 8e-59 199.1 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK71940.1 - 1.8e-24 86.5 0.0 3.3e-24 85.6 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK71940.1 - 9.4e-06 25.1 0.3 1.6e-05 24.4 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK71940.1 - 0.00011 21.6 0.0 0.00036 19.9 0.1 1.7 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 VDK71940.1 - 0.00082 19.0 0.2 0.0016 18.0 0.2 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 VDK71940.1 - 0.00095 19.1 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family HI0933_like PF03486.14 VDK71940.1 - 0.14 10.8 0.4 0.44 9.2 0.4 1.7 1 1 0 1 1 1 0 HI0933-like protein NAP PF00956.18 VDK71972.1 - 3.3e-30 105.2 11.0 1.4e-24 86.7 5.2 2.7 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) EzrA PF06160.12 VDK71972.1 - 0.014 13.6 0.5 0.019 13.1 0.5 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Phage_Mu_Gam PF07352.12 VDK71972.1 - 0.021 14.8 1.1 0.06 13.3 0.2 1.9 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein DUF5082 PF16888.5 VDK71972.1 - 0.026 14.8 0.6 0.045 14.0 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Nore1-SARAH PF16517.5 VDK71972.1 - 0.047 13.6 2.0 2.8 7.9 0.1 2.6 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain SAS-6_N PF16531.5 VDK71972.1 - 0.051 14.2 0.4 0.094 13.3 0.1 1.7 2 0 0 2 2 2 0 Centriolar protein SAS N-terminal Cytochrom_B562 PF07361.11 VDK71972.1 - 0.059 14.0 0.2 0.12 13.0 0.2 1.5 1 0 0 1 1 1 0 Cytochrome b562 DUF4407 PF14362.6 VDK71972.1 - 0.064 12.6 0.4 0.091 12.1 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Pup PF05639.11 VDK71972.1 - 0.17 12.8 0.6 0.17 12.8 0.6 2.6 2 0 0 2 2 2 0 Pup-like protein JmjC PF02373.22 VDK71975.1 - 0.022 15.2 0.0 0.056 13.9 0.0 1.7 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_4 PF08007.12 VDK71975.1 - 0.082 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Cupin superfamily protein DUF3537 PF12056.8 VDK71975.1 - 1.2 7.9 3.4 14 4.4 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) An_peroxidase PF03098.15 VDK71976.1 - 1.3e-187 624.6 0.0 4.4e-187 622.9 0.0 1.7 2 0 0 2 2 2 1 Animal haem peroxidase I-set PF07679.16 VDK71976.1 - 8.7e-31 105.9 0.2 2.6e-18 65.9 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK71976.1 - 3.7e-29 101.1 1.2 7.6e-18 64.9 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 VDK71976.1 - 1.3e-19 70.1 1.2 8.2e-12 45.1 0.0 3.3 3 0 0 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 VDK71976.1 - 1e-17 64.2 0.1 8e-10 38.9 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain V-set PF07686.17 VDK71976.1 - 1.9e-06 28.0 1.2 0.025 14.8 0.2 3.5 2 1 0 2 2 2 1 Immunoglobulin V-set domain Ig_4 PF16680.5 VDK71976.1 - 0.0041 17.3 0.0 0.28 11.5 0.0 2.8 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain C2-set_2 PF08205.12 VDK71976.1 - 0.0087 16.1 0.0 0.11 12.6 0.0 2.8 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 VDK71976.1 - 0.015 15.3 0.0 5.6 7.1 0.0 3.4 3 0 0 3 3 3 0 C17orf99 Ig domain BicD PF09730.9 VDK71978.1 - 2.2e-106 357.0 79.8 2.3e-62 211.5 26.3 3.8 2 1 1 3 3 3 3 Microtubule-associated protein Bicaudal-D Peptidase_C78 PF07910.13 VDK71979.1 - 3.5e-46 157.3 0.2 4.9e-46 156.9 0.2 1.2 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 VDK71979.1 - 0.042 13.3 0.1 0.27 10.6 0.0 2.0 2 0 0 2 2 2 0 Peptidase family C54 V-ATPase_C PF03223.15 VDK71980.1 - 2.6e-150 500.9 3.5 3e-150 500.8 3.5 1.0 1 0 0 1 1 1 1 V-ATPase subunit C Baculo_PEP_C PF04513.12 VDK71980.1 - 0.022 14.8 1.7 0.04 14.0 1.7 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Gar1 PF04410.14 VDK71982.1 - 9.1e-30 103.5 0.0 5.5e-22 78.2 0.1 2.2 2 0 0 2 2 2 2 Gar1/Naf1 RNA binding region Rotavirus_VP7 PF05868.11 VDK71982.1 - 0.027 13.8 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Rotavirus major outer capsid protein VP7 CDC50 PF03381.15 VDK71984.1 - 1.1e-87 294.2 0.2 1.3e-87 293.9 0.2 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Ldl_recept_a PF00057.18 VDK71987.1 - 7.8e-09 35.6 2.7 2.1e-08 34.2 2.7 1.8 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A CUB PF00431.20 VDK71987.1 - 1.2e-08 35.3 0.0 7.4e-07 29.5 0.0 2.5 1 1 0 1 1 1 1 CUB domain zf-C2H2 PF00096.26 VDK71989.1 - 2.5e-09 37.1 69.9 0.016 15.7 5.8 8.4 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK71989.1 - 1.2e-07 31.9 61.8 0.091 13.6 3.6 8.5 8 0 0 8 8 8 6 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK71989.1 - 0.00014 22.2 4.5 0.00014 22.2 4.5 7.6 9 0 0 9 9 9 4 Zinc-finger double domain zf-C2HE PF16278.5 VDK71989.1 - 0.00034 21.0 0.9 0.00034 21.0 0.9 6.0 5 1 2 7 7 7 1 C2HE / C2H2 / C2HC zinc-binding finger BolA PF01722.18 VDK71989.1 - 0.043 14.1 3.1 0.14 12.5 2.6 2.2 1 1 0 1 1 1 0 BolA-like protein zf_C2H2_ZHX PF18387.1 VDK71989.1 - 5.2 6.8 19.7 0.078 12.6 0.6 4.6 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain Ig_3 PF13927.6 VDK71991.1 - 3.3e-63 210.2 1.3 9.8e-08 32.5 0.0 9.6 9 0 0 9 9 9 9 Immunoglobulin domain ig PF00047.25 VDK71991.1 - 3.8e-44 148.8 4.3 8.7e-07 29.0 0.1 9.1 9 0 0 9 9 9 8 Immunoglobulin domain Ig_2 PF13895.6 VDK71991.1 - 5.3e-44 148.4 3.3 0.00018 21.8 0.0 9.5 8 1 1 9 9 9 9 Immunoglobulin domain I-set PF07679.16 VDK71991.1 - 7.7e-43 144.5 0.0 1.5e-06 28.2 0.0 9.1 9 0 0 9 9 9 8 Immunoglobulin I-set domain C2-set_2 PF08205.12 VDK71991.1 - 1.7e-42 143.4 4.8 2.2e-12 46.9 0.0 7.0 7 0 0 7 7 7 5 CD80-like C2-set immunoglobulin domain V-set PF07686.17 VDK71991.1 - 2.1e-12 47.2 4.8 0.026 14.7 0.1 10.0 10 2 0 10 10 10 2 Immunoglobulin V-set domain C1-set PF07654.15 VDK71991.1 - 7.5e-11 42.3 1.4 0.032 14.6 0.0 6.2 6 0 0 6 6 6 2 Immunoglobulin C1-set domain fn3 PF00041.21 VDK71991.1 - 1.2e-09 38.3 0.0 5.7e-09 36.2 0.0 2.3 1 0 0 1 1 1 1 Fibronectin type III domain 7TM_GPCR_Srv PF10323.9 VDK71991.1 - 0.15 11.4 0.2 0.28 10.5 0.2 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv LRR_8 PF13855.6 VDK71993.1 - 1.6e-49 165.5 58.9 8e-15 54.4 0.5 5.4 3 1 3 6 6 6 6 Leucine rich repeat EGF PF00008.27 VDK71993.1 - 1.1e-30 105.5 91.1 1.4e-06 28.4 4.7 8.7 9 0 0 9 9 8 6 EGF-like domain hEGF PF12661.7 VDK71993.1 - 4.9e-18 65.0 66.9 2.9e-05 24.5 2.3 9.0 8 0 0 8 8 7 6 Human growth factor-like EGF Laminin_G_1 PF00054.23 VDK71993.1 - 9.4e-18 64.7 0.0 1.9e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain Laminin_G_2 PF02210.24 VDK71993.1 - 2.3e-17 63.8 0.0 4.2e-17 62.9 0.0 1.5 1 0 0 1 1 1 1 Laminin G domain LRR_4 PF12799.7 VDK71993.1 - 1.5e-16 60.2 29.4 3.2e-05 24.2 1.1 6.4 3 2 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK71993.1 - 1.3e-14 54.2 1.5 1.6e-10 41.0 0.0 3.6 3 0 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRRNT PF01462.18 VDK71993.1 - 3.2e-14 52.2 13.0 1.8e-09 37.0 2.2 6.6 8 0 0 8 8 5 3 Leucine rich repeat N-terminal domain LRR_9 PF14580.6 VDK71993.1 - 1.4e-08 34.4 7.4 0.037 13.5 0.3 3.3 2 1 1 3 3 3 3 Leucine-rich repeat LRRCT PF01463.24 VDK71993.1 - 0.0032 17.9 4.7 0.035 14.6 0.1 4.2 4 0 0 4 4 4 1 Leucine rich repeat C-terminal domain EGF_3 PF12947.7 VDK71993.1 - 0.0068 16.6 2.6 0.0068 16.6 2.6 9.4 11 0 0 11 11 8 3 EGF domain LRR_6 PF13516.6 VDK71993.1 - 0.02 14.9 18.9 3.6 7.9 0.2 6.2 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 VDK71993.1 - 0.024 15.1 34.2 0.54 11.0 0.0 9.9 10 2 1 11 11 8 0 Leucine Rich Repeat LRR_8 PF13855.6 VDK72014.1 - 5.6e-37 125.3 74.3 5.2e-10 38.9 4.7 10.4 7 3 1 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 VDK72014.1 - 4.1e-25 87.4 71.8 1.2e-05 25.5 1.8 11.5 8 3 2 10 10 10 6 Leucine Rich repeats (2 copies) PP2C PF00481.21 VDK72014.1 - 4.2e-16 59.4 0.0 7.1e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_1 PF00560.33 VDK72014.1 - 2.1e-07 30.5 54.7 8 7.4 0.0 16.1 16 0 0 16 16 16 3 Leucine Rich Repeat LRR_9 PF14580.6 VDK72014.1 - 7e-07 28.9 21.3 0.018 14.5 3.3 4.9 2 1 1 4 4 4 3 Leucine-rich repeat LRR_5 PF13306.6 VDK72014.1 - 0.0015 18.5 5.2 3.1 7.8 0.9 3.6 3 0 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) PhaP_Bmeg PF09602.10 VDK72014.1 - 0.13 12.2 0.0 1.9 8.4 0.0 2.3 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) LRR_6 PF13516.6 VDK72014.1 - 2.1 8.6 57.2 2.8 8.2 0.2 13.6 15 1 1 16 16 16 0 Leucine Rich repeat Guanylate_cyc PF00211.20 VDK72015.1 - 1.4e-103 344.2 0.1 9.3e-57 191.6 0.1 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF1053 PF06327.14 VDK72015.1 - 0.00015 22.3 0.0 0.00056 20.4 0.0 2.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1053) AC_N PF16214.5 VDK72015.1 - 0.0043 16.3 0.3 0.0043 16.3 0.3 2.7 3 0 0 3 3 3 1 Adenylyl cyclase N-terminal extracellular and transmembrane region Phage_holin_3_6 PF07332.11 VDK72015.1 - 2.8 8.0 11.3 5.8 7.0 0.0 3.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III FH2 PF02181.23 VDK72016.1 - 3e-70 237.2 4.5 6.3e-70 236.2 4.5 1.5 1 0 0 1 1 1 1 Formin Homology 2 Domain Cnd1 PF12717.7 VDK72016.1 - 0.039 14.0 0.8 0.11 12.5 0.8 1.8 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 P4Ha_N PF08336.11 VDK72016.1 - 6.1 6.9 8.6 1 9.4 0.2 3.1 2 1 1 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Ribosomal_S3Ae PF01015.18 VDK72017.1 - 6.7e-93 309.9 2.3 8.4e-93 309.5 2.3 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family NLRC4_HD2 PF17776.1 VDK72017.1 - 0.045 14.3 0.0 0.071 13.6 0.0 1.3 1 0 0 1 1 1 0 NLRC4 helical domain HD2 Abhydro_lipase PF04083.16 VDK72017.1 - 0.061 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region DUF4024 PF13216.6 VDK72017.1 - 0.13 12.2 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) EIF4E-T PF10477.9 VDK72018.1 - 3.9e-22 78.9 31.0 6.5e-15 55.0 16.3 2.8 2 1 1 3 3 3 2 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Glyco_transf_64 PF09258.10 VDK72019.1 - 4e-62 209.7 0.2 2.1e-60 204.0 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 64 domain Exostosin PF03016.15 VDK72019.1 - 3.5e-19 69.1 0.0 8.5e-19 67.9 0.0 1.7 1 1 0 1 1 1 1 Exostosin family Pkinase PF00069.25 VDK72020.1 - 1.4e-69 234.4 0.0 5.1e-69 232.6 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK72020.1 - 1.1e-28 100.3 0.0 1.9e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 VDK72020.1 - 4.3e-17 62.5 4.1 9.8e-17 61.3 4.1 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain PH PF00169.29 VDK72020.1 - 0.00015 22.2 0.0 0.00032 21.2 0.0 1.6 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 VDK72020.1 - 0.0038 16.6 0.0 0.0074 15.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 VDK72020.1 - 0.0046 16.0 0.5 0.015 14.3 0.2 1.9 1 1 1 2 2 2 1 Haspin like kinase domain Stirrup PF09061.6 VDK72020.1 - 0.011 16.0 0.0 0.032 14.4 0.0 1.8 1 0 0 1 1 1 0 Stirrup YccJ PF13993.6 VDK72020.1 - 0.13 12.6 0.1 0.37 11.2 0.1 1.7 1 0 0 1 1 1 0 YccJ-like protein Cyt-b5 PF00173.28 VDK72021.1 - 4.7e-12 45.9 0.0 7.3e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Y_phosphatase PF00102.27 VDK72022.1 - 1e-68 231.4 0.0 1.9e-68 230.5 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK72022.1 - 0.0017 18.2 0.4 0.0078 16.0 0.0 2.3 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 VDK72022.1 - 0.0087 16.2 0.0 0.49 10.5 0.0 2.7 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 VDK72022.1 - 0.02 14.8 0.0 0.043 13.8 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF4807 PF16065.5 VDK72029.1 - 1.5e-39 134.6 0.1 2.1e-39 134.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4807) SIKE PF05769.11 VDK72047.1 - 8.6e-42 143.1 12.3 1.1e-41 142.7 12.3 1.1 1 0 0 1 1 1 1 SIKE family BicD PF09730.9 VDK72047.1 - 0.0014 17.2 6.0 0.0017 16.9 6.0 1.1 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D DUF5094 PF17015.5 VDK72047.1 - 0.0015 18.7 6.1 0.49 10.5 0.1 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF5094) Herpes_BLRF2 PF05812.12 VDK72047.1 - 0.11 12.7 2.5 2.2 8.5 0.1 3.0 3 0 0 3 3 3 0 Herpesvirus BLRF2 protein TolA_bind_tri PF16331.5 VDK72047.1 - 1 9.5 15.7 0.059 13.5 7.4 2.7 3 0 0 3 3 3 0 TolA binding protein trimerisation OmpH PF03938.14 VDK72047.1 - 1.9 8.8 7.7 3.4 8.0 7.7 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) FBPase PF00316.20 VDK72048.1 - 4.3e-75 251.3 0.3 6.3e-75 250.8 0.3 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 VDK72048.1 - 0.0094 15.5 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 1 Inositol monophosphatase family Collagen PF01391.18 VDK72049.1 - 1.7e-21 75.8 86.5 1.9e-07 30.7 32.2 4.4 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK72049.1 - 6.5e-19 67.7 0.0 8.8e-19 67.3 0.0 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain DSL PF01414.19 VDK72050.1 - 0.012 15.9 0.5 0.039 14.2 0.5 1.9 1 0 0 1 1 1 0 Delta serrate ligand DUF4064 PF13273.6 VDK72050.1 - 0.026 14.8 0.1 0.052 13.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Tmemb_9 PF05434.11 VDK72050.1 - 0.11 12.3 0.1 0.28 11.1 0.1 1.6 1 0 0 1 1 1 0 TMEM9 DUF4834 PF16118.5 VDK72050.1 - 0.2 12.6 0.1 0.37 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) AA_permease PF00324.21 VDK72054.1 - 1e-56 192.5 33.0 1.1e-40 139.7 3.7 2.2 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 VDK72054.1 - 2.4e-33 115.8 11.3 2.8e-14 53.0 0.3 3.8 1 1 3 4 4 4 3 Solute carrier family 12 AA_permease_2 PF13520.6 VDK72054.1 - 7.4e-15 54.7 38.1 1.3e-14 53.9 10.5 2.1 2 0 0 2 2 2 2 Amino acid permease Pkinase PF00069.25 VDK72055.1 - 4.7e-35 121.2 0.0 6.6e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK72055.1 - 1.2e-19 70.7 0.0 1.7e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK72055.1 - 0.00017 21.0 0.0 0.00042 19.7 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK72055.1 - 0.0038 16.1 0.0 0.0063 15.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK72055.1 - 0.022 14.7 0.0 0.21 11.5 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4207 PF13904.6 VDK72057.1 - 2.7e-06 27.3 79.7 4e-06 26.7 53.9 3.2 1 1 1 3 3 3 3 Domain of unknown function (DUF4207) Ins145_P3_rec PF08709.11 VDK72063.1 - 6.1e-72 241.3 1.0 1.7e-70 236.5 0.1 3.0 1 1 2 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.21 VDK72063.1 - 5.1e-54 182.8 17.6 3.7e-51 173.4 0.2 4.6 3 1 1 4 4 4 3 RIH domain MIR PF02815.19 VDK72063.1 - 1.1e-39 136.2 0.1 2.3e-34 118.9 0.0 3.6 2 1 0 2 2 2 2 MIR domain RIH_assoc PF08454.11 VDK72063.1 - 1.6e-29 101.7 3.0 1.6e-29 101.7 3.0 4.6 5 0 0 5 5 5 1 RyR and IP3R Homology associated Ion_trans PF00520.31 VDK72063.1 - 1.2e-18 67.2 1.0 2.8e-18 66.1 0.5 1.8 1 1 1 2 2 2 1 Ion transport protein Novirhabdo_Nv PF05554.11 VDK72063.1 - 0.013 15.3 2.5 0.063 13.0 0.1 2.7 2 0 0 2 2 2 0 Viral hemorrhagic septicemia virus non-virion protein DUF1830 PF08865.11 VDK72063.1 - 0.034 14.2 0.3 0.2 11.7 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1830) RNA_pol_Rpb4 PF03874.16 VDK72063.1 - 0.82 10.0 4.4 2.1 8.7 0.1 3.9 3 0 0 3 3 3 0 RNA polymerase Rpb4 ATP-gua_Ptrans PF00217.19 VDK72065.1 - 1.4e-59 201.1 0.0 2e-59 200.6 0.0 1.2 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN PF02807.15 VDK72065.1 - 9.9e-22 77.1 0.0 1.9e-21 76.2 0.0 1.5 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain UPF0184 PF03670.13 VDK72065.1 - 0.15 12.5 0.1 6.1 7.3 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) Sugar_tr PF00083.24 VDK72069.1 - 7.7e-108 361.2 35.6 5.9e-85 285.8 14.9 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 VDK72069.1 - 3.2e-29 102.0 29.6 2.2e-27 95.9 22.2 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 VDK72069.1 - 3e-05 22.7 1.7 4.9e-05 21.9 1.7 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CAP PF00188.26 VDK72086.1 - 3.9e-17 63.3 6.3 3.9e-17 63.3 6.3 2.3 2 0 0 2 2 2 1 Cysteine-rich secretory protein family ShK PF01549.24 VDK72086.1 - 1.7e-05 25.3 5.6 1.7e-05 25.3 5.6 3.2 4 0 0 4 4 4 1 ShK domain-like DUF2524 PF10732.9 VDK72086.1 - 0.56 10.6 4.6 0.16 12.3 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) Carb_anhydrase PF00194.21 VDK72090.1 - 9.6e-69 231.7 0.1 1.1e-68 231.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Oxysterol_BP PF01237.18 VDK72091.1 - 5e-111 371.1 3.5 1.3e-110 369.8 3.5 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein Lipase_2 PF01674.18 VDK72096.1 - 4.3e-54 183.3 0.1 5e-54 183.1 0.1 1.0 1 0 0 1 1 1 1 Lipase (class 2) Palm_thioest PF02089.15 VDK72096.1 - 0.00039 20.3 0.0 0.00047 20.1 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase LCAT PF02450.15 VDK72096.1 - 0.0013 18.0 0.0 0.0017 17.6 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 VDK72096.1 - 0.0074 15.8 0.0 0.011 15.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 VDK72096.1 - 0.017 14.9 0.1 0.049 13.3 0.1 1.7 2 0 0 2 2 2 0 PGAP1-like protein DUF676 PF05057.14 VDK72096.1 - 0.055 13.0 0.0 0.08 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 VDK72096.1 - 0.12 13.0 0.0 0.16 12.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Metallothio_Pro PF02069.16 VDK72102.1 - 0.048 13.9 2.0 0.21 11.8 2.0 2.2 1 0 0 1 1 1 0 Prokaryotic metallothionein Neur_chan_memb PF02932.16 VDK72102.1 - 0.66 10.0 3.9 0.65 10.0 0.7 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RRM_1 PF00076.22 VDK72103.1 - 2.5e-60 200.2 0.3 2.1e-15 56.3 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK72103.1 - 1.5e-10 41.1 1.5 0.69 10.1 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif DUF4715 PF15835.5 VDK72103.1 - 0.012 15.7 0.8 1.3 9.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4715) RRM_3 PF08777.11 VDK72103.1 - 0.052 13.6 0.9 73 3.5 0.0 4.3 4 1 0 4 4 4 0 RNA binding motif Strep_his_triad PF04270.13 VDK72103.1 - 0.11 12.5 0.2 15 5.7 0.1 2.5 2 0 0 2 2 2 0 Streptococcal histidine triad protein Flu_NS1 PF00600.19 VDK72103.1 - 0.26 10.8 0.7 9.2 5.8 0.1 2.2 2 0 0 2 2 2 0 Influenza non-structural protein (NS1) AGP PF06376.12 VDK72103.1 - 0.58 10.1 4.0 6 6.8 0.4 2.4 2 0 0 2 2 2 0 Arabinogalactan peptide DUF410 PF04190.13 VDK72105.1 - 1.1e-62 212.2 0.0 1.4e-62 211.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) CDC45 PF02724.14 VDK72105.1 - 0.027 12.8 0.1 0.036 12.4 0.1 1.1 1 0 0 1 1 1 0 CDC45-like protein TPR_14 PF13428.6 VDK72105.1 - 0.12 13.2 0.2 1.4e+02 3.7 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat AhpC-TSA PF00578.21 VDK72106.1 - 4.7e-29 100.8 0.0 7e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK72106.1 - 1.5e-13 50.7 0.0 2.1e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 VDK72106.1 - 6.4e-10 38.7 0.2 1.1e-09 38.0 0.2 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 VDK72106.1 - 0.00034 20.7 0.0 0.031 14.4 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme ISPD_C PF18706.1 VDK72106.1 - 0.045 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain GST_C_3 PF14497.6 VDK72107.1 - 4.2e-21 75.0 0.1 6.9e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 VDK72107.1 - 3.2e-14 52.9 0.0 4.8e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 VDK72107.1 - 4.6e-06 26.9 0.0 1.5e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 VDK72107.1 - 6.4e-05 22.9 0.1 0.00074 19.5 0.0 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 VDK72107.1 - 0.037 14.4 0.0 0.087 13.2 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Importin_rep_4 PF18808.1 VDK72110.1 - 1e-26 93.0 2.9 1.4e-25 89.4 0.2 3.4 2 0 0 2 2 2 1 Importin repeat HEAT_EZ PF13513.6 VDK72110.1 - 1.2e-16 60.8 0.5 1.2e-11 44.9 0.0 6.8 9 1 0 9 9 8 1 HEAT-like repeat HEAT PF02985.22 VDK72110.1 - 7.3e-12 44.5 10.3 0.00019 21.4 0.0 7.7 10 0 0 10 10 10 2 HEAT repeat HEAT_2 PF13646.6 VDK72110.1 - 1.3e-11 44.7 0.0 1.8e-06 28.3 0.0 5.5 5 1 0 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.7 VDK72110.1 - 4.6e-09 36.8 0.4 4.2e-06 27.3 0.0 4.9 5 1 0 5 5 5 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 VDK72110.1 - 2.4e-07 31.0 0.0 0.00025 21.1 0.0 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Importin_rep_6 PF18829.1 VDK72110.1 - 0.00019 21.5 3.3 0.00022 21.3 0.2 2.7 3 0 0 3 3 3 1 Importin repeat 6 MMS19_C PF12460.8 VDK72110.1 - 0.00021 20.6 0.5 0.54 9.3 0.0 3.3 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 VDK72110.1 - 0.018 14.9 1.9 4.6 7.1 0.0 4.3 2 2 0 4 4 4 0 Domain of unknown function (DUF3385) RIX1 PF08167.12 VDK72110.1 - 0.16 11.7 0.1 4.6 6.9 0.2 3.2 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis DUF1981 PF09324.10 VDK72110.1 - 0.17 11.8 0.4 42 4.1 0.1 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1981) Importin_rep_4 PF18808.1 VDK72111.1 - 1e-26 93.1 2.9 1.4e-25 89.4 0.2 3.4 2 0 0 2 2 2 1 Importin repeat HEAT_EZ PF13513.6 VDK72111.1 - 1.6e-16 60.4 0.8 1.1e-11 44.9 0.0 6.7 8 2 1 9 9 9 1 HEAT-like repeat HEAT PF02985.22 VDK72111.1 - 2.2e-12 46.1 9.1 0.00019 21.4 0.0 7.8 10 0 0 10 10 10 2 HEAT repeat HEAT_2 PF13646.6 VDK72111.1 - 7.5e-12 45.5 0.2 1.7e-06 28.3 0.0 5.8 5 2 1 6 6 6 1 HEAT repeats Vac14_Fab1_bd PF12755.7 VDK72111.1 - 4.3e-08 33.6 0.2 4.2e-06 27.3 0.0 4.4 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 VDK72111.1 - 2.4e-07 31.0 0.0 0.00025 21.1 0.0 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Importin_rep_6 PF18829.1 VDK72111.1 - 0.00022 21.3 0.2 0.00022 21.3 0.2 2.7 3 0 0 3 3 3 1 Importin repeat 6 MMS19_C PF12460.8 VDK72111.1 - 0.0035 16.5 0.2 2.6 7.1 0.1 3.4 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 VDK72111.1 - 0.013 15.4 0.7 4.5 7.2 0.0 4.0 2 1 2 5 5 5 0 Domain of unknown function (DUF3385) GST_C_3 PF14497.6 VDK72113.1 - 4.2e-21 75.0 0.1 6.9e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 VDK72113.1 - 3.2e-14 52.9 0.0 4.8e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 VDK72113.1 - 4.6e-06 26.9 0.0 1.5e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 VDK72113.1 - 6.4e-05 22.9 0.1 0.00074 19.5 0.0 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 VDK72113.1 - 0.037 14.4 0.0 0.087 13.2 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain AhpC-TSA PF00578.21 VDK72115.1 - 4.7e-29 100.8 0.0 7e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK72115.1 - 1.5e-13 50.7 0.0 2.1e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 VDK72115.1 - 6.4e-10 38.7 0.2 1.1e-09 38.0 0.2 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 VDK72115.1 - 0.00034 20.7 0.0 0.031 14.4 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme ISPD_C PF18706.1 VDK72115.1 - 0.045 13.4 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain DUF410 PF04190.13 VDK72116.1 - 1.4e-61 208.5 0.0 1.9e-61 208.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF410) RRM_1 PF00076.22 VDK72116.1 - 1.7e-59 197.6 0.3 3.5e-15 55.6 0.0 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK72116.1 - 1.1e-09 38.3 1.5 1.1 9.4 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif DUF4715 PF15835.5 VDK72116.1 - 0.029 14.4 0.8 2.1 8.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4715) CDC45 PF02724.14 VDK72116.1 - 0.13 10.6 0.1 0.19 10.0 0.1 1.1 1 0 0 1 1 1 0 CDC45-like protein RRM_3 PF08777.11 VDK72116.1 - 0.26 11.4 0.8 1.2e+02 2.7 0.0 4.1 4 1 0 4 4 4 0 RNA binding motif AGP PF06376.12 VDK72116.1 - 1.3 8.9 4.0 9.4 6.2 0.4 2.4 2 0 0 2 2 2 0 Arabinogalactan peptide Metallothio_Pro PF02069.16 VDK72117.1 - 0.047 13.9 2.0 0.21 11.9 2.0 2.2 1 0 0 1 1 1 0 Prokaryotic metallothionein Neur_chan_memb PF02932.16 VDK72117.1 - 1.3 9.0 4.9 0.63 10.1 0.7 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Lipase_2 PF01674.18 VDK72119.1 - 7e-54 182.6 0.1 8.6e-54 182.4 0.1 1.1 1 0 0 1 1 1 1 Lipase (class 2) Palm_thioest PF02089.15 VDK72119.1 - 0.00054 19.9 0.7 0.00073 19.5 0.0 1.5 2 0 0 2 2 2 1 Palmitoyl protein thioesterase LCAT PF02450.15 VDK72119.1 - 0.0018 17.6 0.0 0.0023 17.1 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 VDK72119.1 - 0.009 15.5 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 VDK72119.1 - 0.022 14.5 0.1 0.065 12.9 0.1 1.8 2 0 0 2 2 2 0 PGAP1-like protein DUF676 PF05057.14 VDK72119.1 - 0.076 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 VDK72119.1 - 0.16 12.5 0.0 0.23 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Oxysterol_BP PF01237.18 VDK72122.1 - 5e-111 371.1 3.5 1.3e-110 369.8 3.5 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein AIG1 PF04548.16 VDK72135.1 - 5.7e-07 29.1 1.5 9.4e-07 28.4 1.5 1.4 1 1 0 1 1 1 1 AIG1 family AAA_29 PF13555.6 VDK72135.1 - 0.00088 19.0 0.0 0.0025 17.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 VDK72135.1 - 0.0059 17.1 0.1 0.0081 16.7 0.1 1.4 1 1 0 1 1 1 1 AAA domain LRR_8 PF13855.6 VDK72135.1 - 0.08 12.7 3.7 0.19 11.5 3.4 1.8 1 1 1 2 2 2 0 Leucine rich repeat Neur_chan_LBD PF02931.23 VDK72136.1 - 3.8e-39 134.4 1.1 6e-39 133.7 1.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK72136.1 - 1.7e-24 87.3 2.4 1.9e-18 67.4 0.3 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region PKI PF02827.16 VDK72140.1 - 7.4e-09 35.7 2.3 1.1e-08 35.1 0.7 2.0 1 1 2 3 3 3 1 cAMP-dependent protein kinase inhibitor Host_attach PF10116.9 VDK72140.1 - 0.029 14.9 0.1 0.036 14.6 0.1 1.1 1 0 0 1 1 1 0 Protein required for attachment to host cells Baculo_11_kDa PF06143.11 VDK72140.1 - 0.071 12.7 0.1 0.098 12.2 0.1 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Ras PF00071.22 VDK72142.1 - 7.8e-22 77.6 0.0 1.1e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK72142.1 - 0.0021 18.3 0.0 0.0045 17.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 VDK72142.1 - 0.095 12.2 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B CSF-1 PF05337.11 VDK72145.1 - 0.14 12.2 2.5 1.5 8.9 0.1 2.6 3 0 0 3 3 3 0 Macrophage colony stimulating factor-1 (CSF-1) Ras PF00071.22 VDK72148.1 - 1.3e-32 112.6 0.1 1.4e-32 112.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK72148.1 - 2.9e-29 101.7 0.1 3.1e-29 101.6 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK72148.1 - 3.7e-10 39.5 0.1 3.9e-10 39.4 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 VDK72148.1 - 2.3e-05 23.9 0.1 2.8e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 VDK72148.1 - 0.00015 21.8 0.0 0.00018 21.6 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK72148.1 - 0.00043 19.7 0.0 0.0005 19.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 VDK72148.1 - 0.019 14.5 0.0 0.12 11.9 0.0 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 VDK72148.1 - 0.035 13.6 0.0 0.051 13.1 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Dynamin_N PF00350.23 VDK72148.1 - 0.13 12.4 0.0 3.5 7.7 0.0 2.1 2 0 0 2 2 2 0 Dynamin family Cyt-b5 PF00173.28 VDK72149.1 - 6.6e-20 71.0 0.2 1.9e-19 69.6 0.0 1.7 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF632 PF04782.12 VDK72149.1 - 0.082 12.2 0.1 0.082 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF632) Bax1-I PF01027.20 VDK72150.1 - 6.1e-39 134.0 27.6 7.3e-39 133.7 27.6 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF5084 PF16894.5 VDK72150.1 - 4.5 7.7 18.5 0.3 11.5 9.1 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5084) DB PF01682.19 VDK72152.1 - 7.1e-14 51.9 15.1 7.1e-14 51.9 15.1 2.5 2 0 0 2 2 2 2 DB module TMF_TATA_bd PF12325.8 VDK72153.1 - 0.00022 21.4 1.4 0.016 15.4 0.2 2.3 2 0 0 2 2 2 2 TATA element modulatory factor 1 TATA binding ATG16 PF08614.11 VDK72153.1 - 0.026 14.8 1.2 0.043 14.0 1.2 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) USP8_interact PF08941.10 VDK72153.1 - 0.068 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 USP8 interacting PspA_IM30 PF04012.12 VDK72153.1 - 0.076 12.6 0.5 0.12 11.9 0.5 1.2 1 0 0 1 1 1 0 PspA/IM30 family Syntaxin-6_N PF09177.11 VDK72153.1 - 0.11 13.0 0.1 0.31 11.6 0.1 1.7 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DP PF08781.10 VDK72154.1 - 4.7e-56 188.5 0.3 1.1e-55 187.4 0.3 1.6 1 0 0 1 1 1 1 Transcription factor DP E2F_TDP PF02319.20 VDK72154.1 - 9.8e-27 92.8 0.3 2e-26 91.8 0.3 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain PcfK PF14058.6 VDK72154.1 - 0.039 14.2 2.8 0.11 12.8 2.8 1.7 1 0 0 1 1 1 0 PcfK-like protein HSP20 PF00011.21 VDK72155.1 - 1.5e-16 60.4 0.2 3.1e-16 59.4 0.2 1.6 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DUF3752 PF12572.8 VDK72156.1 - 1.3e-13 51.7 1.4 1.3e-13 51.7 1.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Methyltransf_7 PF03492.15 VDK72156.1 - 0.084 12.1 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase Pkinase PF00069.25 VDK72158.1 - 2.1e-67 227.3 0.0 3e-67 226.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK72158.1 - 1.5e-48 165.4 0.0 2.2e-48 164.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mst1_SARAH PF11629.8 VDK72158.1 - 2.2e-16 59.7 3.9 4.9e-16 58.5 3.9 1.6 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Pkinase_fungal PF17667.1 VDK72158.1 - 9e-10 37.9 0.0 1.6e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK72158.1 - 0.03 13.7 0.3 0.18 11.2 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 VDK72158.1 - 0.075 12.0 0.1 3.2 6.6 0.1 2.3 1 1 0 1 1 1 0 Haspin like kinase domain Abi_2 PF07751.11 VDK72158.1 - 0.091 13.0 0.1 0.26 11.5 0.0 1.7 2 0 0 2 2 2 0 Abi-like protein zf-C4 PF00105.18 VDK72161.1 - 6.3e-27 93.8 13.7 1.1e-26 93.0 13.7 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK72161.1 - 2.8e-22 79.3 6.1 1e-10 41.6 3.3 3.1 2 1 0 2 2 2 2 Ligand-binding domain of nuclear hormone receptor Beach PF02138.18 VDK72163.1 - 2.4e-106 355.1 0.0 4.9e-106 354.1 0.0 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 VDK72163.1 - 1.8e-13 50.4 0.2 6.3e-13 48.7 0.2 2.0 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH GPI2 PF06432.11 VDK72164.1 - 5.7e-42 144.1 12.6 6.7e-42 143.9 12.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase MPC PF03650.13 VDK72164.1 - 0.075 13.2 4.1 0.88 9.7 0.2 2.3 1 1 1 2 2 2 0 Mitochondrial pyruvate carriers Kunitz_BPTI PF00014.23 VDK72184.1 - 8.8e-06 25.9 8.9 1.5e-05 25.1 8.9 1.4 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Forkhead PF00250.18 VDK72186.1 - 1.8e-17 63.3 1.9 1.4e-14 54.1 1.2 2.5 1 1 1 2 2 2 2 Forkhead domain YabA PF06156.13 VDK72187.1 - 0.011 16.4 10.2 0.011 16.4 10.2 16.8 2 2 12 14 14 14 0 Initiation control protein YabA PA14 PF07691.12 VDK72187.1 - 0.14 11.9 0.2 0.89 9.4 0.0 2.4 2 0 0 2 2 2 0 PA14 domain ApoL PF05461.11 VDK72188.1 - 0.00094 18.6 0.3 0.0012 18.2 0.3 1.2 1 0 0 1 1 1 1 Apolipoprotein L Spc7 PF08317.11 VDK72188.1 - 0.0033 16.4 1.0 0.0041 16.0 1.0 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein AAA_22 PF13401.6 VDK72188.1 - 0.046 14.0 0.2 1.6 9.0 0.2 2.5 1 1 2 3 3 3 0 AAA domain DUF4404 PF14357.6 VDK72188.1 - 0.057 14.1 0.0 0.48 11.1 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) BRF1 PF07741.13 VDK72188.1 - 0.084 13.2 1.2 0.21 12.0 1.2 1.6 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Retrotrans_gag PF03732.17 VDK72188.1 - 0.13 12.5 5.4 1.1 9.5 1.0 2.6 1 1 1 2 2 2 0 Retrotransposon gag protein FAM76 PF16046.5 VDK72189.1 - 0.02 14.2 0.9 0.021 14.2 0.9 1.0 1 0 0 1 1 1 0 FAM76 protein Rrp15p PF07890.12 VDK72191.1 - 3.7e-14 53.2 4.7 4.6e-14 52.9 4.7 1.2 1 0 0 1 1 1 1 Rrp15p SR-25 PF10500.9 VDK72191.1 - 0.001 18.8 0.4 0.001 18.8 0.4 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF3867 PF12983.7 VDK72191.1 - 0.0059 16.7 0.3 0.011 15.8 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3867) DIX PF00778.17 VDK72191.1 - 0.085 12.7 0.4 7.2 6.5 0.1 2.3 2 0 0 2 2 2 0 DIX domain HI0933_like PF03486.14 VDK72191.1 - 0.1 11.3 0.2 0.12 11.0 0.2 1.1 1 0 0 1 1 1 0 HI0933-like protein HtrL_YibB PF09612.10 VDK72193.1 - 2.2e-73 247.1 0.4 2.6e-73 246.8 0.4 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) DUF382 PF04037.13 VDK72195.1 - 1.6e-57 193.1 0.5 1.6e-57 193.1 0.5 3.6 4 0 0 4 4 4 1 Domain of unknown function (DUF382) PSP PF04046.16 VDK72195.1 - 1.4e-19 69.6 2.8 2.9e-19 68.6 2.8 1.6 1 0 0 1 1 1 1 PSP YL1 PF05764.13 VDK72197.1 - 1.9e-22 80.6 30.3 8.6e-16 58.8 13.7 2.7 2 1 1 3 3 3 2 YL1 nuclear protein YL1_C PF08265.11 VDK72197.1 - 4e-13 48.9 0.1 7.8e-13 47.9 0.1 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain 4HB_MCP_1 PF12729.7 VDK72197.1 - 0.38 10.3 5.5 0.51 9.8 1.1 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction UQ_con PF00179.26 VDK72200.1 - 1.4e-14 53.9 0.0 2.4e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Opy2 PF09463.10 VDK72200.1 - 7.8 6.9 8.0 4.9 7.5 3.9 2.2 2 0 0 2 2 2 0 Opy2 protein QVR PF17064.5 VDK72201.1 - 0.0068 16.6 5.6 0.031 14.5 5.6 1.9 1 1 0 1 1 1 1 Sleepless protein Reticulon PF02453.17 VDK72202.1 - 2.6e-40 138.0 5.0 1.1e-39 135.9 0.3 2.1 2 0 0 2 2 2 2 Reticulon EI24 PF07264.11 VDK72202.1 - 0.0045 17.3 6.4 0.65 10.2 0.7 2.2 2 0 0 2 2 2 2 Etoposide-induced protein 2.4 (EI24) YtxH PF12732.7 VDK72204.1 - 0.044 14.3 1.5 0.28 11.7 1.5 2.4 1 1 0 1 1 1 0 YtxH-like protein DUF2884 PF11101.8 VDK72204.1 - 0.081 12.4 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) DUF883 PF05957.13 VDK72204.1 - 0.61 10.7 5.7 25 5.6 0.2 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) HHV6-IE PF03753.13 VDK72207.1 - 0.031 11.7 0.1 0.037 11.5 0.1 1.0 1 0 0 1 1 1 0 Human herpesvirus 6 immediate early protein Atx10homo_assoc PF09759.9 VDK72208.1 - 0.064 13.3 8.9 0.077 13.0 0.3 3.3 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain BAR PF03114.18 VDK72229.1 - 6e-06 26.1 5.3 0.0036 17.0 0.1 2.0 1 1 1 2 2 2 2 BAR domain Helicase_C_4 PF13871.6 VDK72229.1 - 0.062 13.0 0.5 0.19 11.4 0.5 1.5 1 1 1 2 2 2 0 C-terminal domain on Strawberry notch homologue UEV PF05743.13 VDK72229.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain Hom_end_hint PF05203.16 VDK72229.1 - 0.16 11.9 1.4 0.24 11.3 1.4 1.3 1 0 0 1 1 1 0 Hom_end-associated Hint Collagen PF01391.18 VDK72230.1 - 2.6e-27 94.4 93.1 5.4e-09 35.7 27.6 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Filament PF00038.21 VDK72232.1 - 1.6e-69 234.9 43.3 9.2e-69 232.4 43.3 2.0 1 1 0 1 1 1 1 Intermediate filament protein APG6_N PF17675.1 VDK72232.1 - 2.2e-05 25.0 38.1 0.8 10.2 4.4 4.9 2 1 1 4 4 4 4 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 VDK72232.1 - 0.00021 21.4 33.6 0.0045 17.0 7.1 4.8 1 1 2 4 4 4 3 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 VDK72232.1 - 0.00036 19.5 33.5 0.0069 15.3 8.2 3.0 2 1 1 3 3 3 2 Spc7 kinetochore protein CENP-H PF05837.12 VDK72232.1 - 0.0029 18.0 5.3 0.0029 18.0 5.3 4.7 2 2 2 5 5 5 1 Centromere protein H (CENP-H) WD40_alt PF14077.6 VDK72232.1 - 0.0056 16.5 0.6 0.0056 16.5 0.6 3.3 3 0 0 3 3 2 1 Alternative WD40 repeat motif Myosin_tail_1 PF01576.19 VDK72232.1 - 0.023 12.5 45.0 0.19 9.5 45.0 2.7 1 1 0 1 1 1 0 Myosin tail LMP PF04778.12 VDK72232.1 - 0.05 13.5 17.7 0.027 14.4 1.4 4.5 2 1 3 5 5 4 0 LMP repeated region Snapin_Pallidin PF14712.6 VDK72232.1 - 0.052 14.0 0.4 0.052 14.0 0.4 4.9 3 2 2 5 5 5 0 Snapin/Pallidin YabA PF06156.13 VDK72232.1 - 0.064 13.9 30.4 0.14 12.8 3.7 5.3 2 2 3 5 5 5 0 Initiation control protein YabA DUF5104 PF17117.5 VDK72232.1 - 0.073 13.5 0.5 2 8.9 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5104) Laminin_II PF06009.12 VDK72232.1 - 0.083 12.9 0.1 0.083 12.9 0.1 4.9 4 2 2 6 6 6 0 Laminin Domain II AKNA PF12443.8 VDK72232.1 - 0.11 13.2 3.8 0.12 13.0 1.1 2.6 2 1 0 2 2 1 0 AT-hook-containing transcription factor KxDL PF10241.9 VDK72232.1 - 0.12 12.7 0.3 0.12 12.7 0.3 3.8 4 1 1 5 5 5 0 Uncharacterized conserved protein TSC22 PF01166.18 VDK72232.1 - 0.14 12.4 22.2 1.3 9.4 0.7 5.2 4 1 1 5 5 5 0 TSC-22/dip/bun family DHR10 PF18595.1 VDK72232.1 - 0.22 11.6 40.1 0.11 12.6 7.7 4.9 2 2 3 5 5 5 0 Designed helical repeat protein 10 domain ATG16 PF08614.11 VDK72232.1 - 0.27 11.4 39.4 1.2 9.3 12.5 4.2 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 VDK72232.1 - 0.33 11.0 20.0 2 8.5 0.3 4.6 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 VDK72232.1 - 0.4 10.8 37.5 0.47 10.5 11.2 3.4 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 VDK72232.1 - 0.48 10.4 42.4 0.17 11.9 7.5 4.4 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SOGA PF11365.8 VDK72232.1 - 0.51 11.5 26.5 2.9 9.1 2.1 5.4 1 1 3 5 5 5 0 Protein SOGA DUF2730 PF10805.8 VDK72232.1 - 0.76 9.9 16.0 9.3 6.4 0.2 4.9 2 2 2 5 5 5 0 Protein of unknown function (DUF2730) Fez1 PF06818.15 VDK72232.1 - 0.81 10.1 40.0 0.36 11.3 3.8 3.8 1 1 2 3 3 3 0 Fez1 FlaC_arch PF05377.11 VDK72232.1 - 1.2 9.6 18.4 3.3 8.2 0.6 5.5 6 0 0 6 6 5 0 Flagella accessory protein C (FlaC) HALZ PF02183.18 VDK72232.1 - 2 8.7 11.5 6.9 7.0 0.1 5.2 4 1 0 4 4 4 0 Homeobox associated leucine zipper DUF4988 PF16378.5 VDK72232.1 - 3.7 7.2 6.3 13 5.4 0.7 3.3 3 1 0 3 3 3 0 Domain of unknown function BLOC1_2 PF10046.9 VDK72232.1 - 4.5 7.6 18.2 2 8.7 1.1 4.8 2 2 4 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HTH_Tnp_1 PF01527.20 VDK72232.1 - 5.3 7.4 0.0 5.3 7.4 0.0 3.9 5 1 0 5 5 4 0 Transposase Prefoldin_2 PF01920.20 VDK72232.1 - 7.5 6.6 25.9 2.2 8.3 0.7 5.7 2 2 2 5 5 5 0 Prefoldin subunit RNase_PH PF01138.21 VDK72233.1 - 1.2e-16 61.5 0.0 1.8e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 FSA_C PF10479.9 VDK72234.1 - 3.1e-14 52.1 15.3 1.7e-05 23.2 0.2 4.6 3 2 2 5 5 5 4 Fragile site-associated protein C-terminus XPG_I PF00867.18 VDK72235.1 - 5.1e-24 84.4 0.0 3.1e-23 82.0 0.0 2.5 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 VDK72235.1 - 9.7e-23 80.6 0.0 2.8e-22 79.1 0.0 1.8 1 0 0 1 1 1 1 XPG N-terminal domain Evr1_Alr PF04777.13 VDK72236.1 - 1.4e-18 67.2 0.3 1.4e-18 67.2 0.3 2.7 3 0 0 3 3 3 1 Erv1 / Alr family FAD_SOX PF18371.1 VDK72236.1 - 4.5e-16 59.1 0.0 1e-15 57.9 0.0 1.7 1 0 0 1 1 1 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Thioredoxin PF00085.20 VDK72236.1 - 1.1e-14 54.2 2.1 1.6e-14 53.8 0.4 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 VDK72236.1 - 0.013 15.8 0.5 0.19 12.1 0.1 2.8 2 0 0 2 2 2 0 Thioredoxin-like Thioredoxin_2 PF13098.6 VDK72236.1 - 0.13 12.7 2.0 0.53 10.8 0.3 2.8 3 0 0 3 3 3 0 Thioredoxin-like domain DUF35_N PF12172.8 VDK72236.1 - 1.5 8.8 3.6 0.83 9.6 0.2 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HEPN_Cthe2314 PF18730.1 VDK72238.1 - 0.02 14.9 1.0 0.027 14.5 1.0 1.3 1 1 0 1 1 1 0 Cthe_2314-like HEPN PI3K_P85_iSH2 PF16454.5 VDK72238.1 - 0.026 14.1 0.2 0.045 13.4 0.2 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain P4Ha_N PF08336.11 VDK72238.1 - 0.034 14.2 0.4 0.059 13.4 0.4 1.3 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region LURAP PF14854.6 VDK72238.1 - 0.077 12.9 2.6 0.13 12.2 2.6 1.4 1 1 0 1 1 1 0 Leucine rich adaptor protein ZapB PF06005.12 VDK72238.1 - 0.091 13.2 1.4 0.15 12.5 1.4 1.3 1 0 0 1 1 1 0 Cell division protein ZapB DUF1192 PF06698.11 VDK72238.1 - 0.22 11.6 2.4 0.4 10.8 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) AMPK1_CBM PF16561.5 VDK72241.1 - 9.1e-29 99.5 0.3 1.6e-28 98.7 0.3 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 VDK72241.1 - 2.5e-27 95.0 4.6 4.1e-27 94.3 4.6 1.4 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain 7tm_1 PF00001.21 VDK72243.1 - 5.4e-20 71.8 15.8 5.4e-20 71.8 15.8 1.9 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK72243.1 - 0.21 11.0 22.8 0.051 12.9 16.3 2.3 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx DUF4739 PF15893.5 VDK72244.1 - 0.016 14.7 1.8 0.023 14.3 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4739) Silic_transp PF03842.13 VDK72244.1 - 0.23 9.7 0.3 0.29 9.4 0.3 1.0 1 0 0 1 1 1 0 Silicon transporter DUF2650 PF10853.8 VDK72293.1 - 2.6e-11 43.0 2.1 5.1e-11 42.1 2.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2650) Kinesin PF00225.23 VDK72294.1 - 1.4e-85 287.1 2.3 1.4e-85 287.1 2.3 3.0 4 1 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 VDK72294.1 - 1.5e-14 54.2 0.6 1.5e-14 54.2 0.6 2.2 2 0 0 2 2 2 1 Microtubule binding Bac_DnaA PF00308.18 VDK72294.1 - 0.035 13.9 0.9 0.076 12.8 0.2 1.9 2 0 0 2 2 2 0 Bacterial dnaA protein ResIII PF04851.15 VDK72294.1 - 0.33 10.9 3.3 17 5.4 0.8 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit YqzE PF14038.6 VDK72294.1 - 0.51 10.4 4.1 1.5 8.9 4.1 1.8 1 0 0 1 1 1 0 YqzE-like protein APG6_N PF17675.1 VDK72294.1 - 4.6 7.8 26.2 0.28 11.7 4.7 2.9 3 1 0 3 3 3 0 Apg6 coiled-coil region zf-C2HC5 PF06221.13 VDK72295.1 - 3.6e-12 46.1 9.8 7.5e-12 45.0 9.8 1.6 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type Mito_carr PF00153.27 VDK72296.1 - 6.5e-12 45.2 0.2 9.1e-06 25.5 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein His_Phos_1 PF00300.22 VDK72297.1 - 0.0015 18.3 0.0 0.0031 17.2 0.0 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Mito_carr PF00153.27 VDK72298.1 - 4.1e-66 219.0 4.7 2e-24 85.3 0.2 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein BRAP2 PF07576.12 VDK72299.1 - 5.5e-29 100.3 0.0 1.4e-28 99.0 0.0 1.7 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 VDK72299.1 - 3.4e-20 72.1 1.8 1.1e-19 70.5 1.8 1.9 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 VDK72299.1 - 2e-09 37.6 6.0 2e-09 37.6 6.0 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK72299.1 - 2.6e-09 36.7 5.9 2.6e-09 36.7 5.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK72299.1 - 2.1e-06 27.9 4.4 1.1e-05 25.6 4.4 2.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 VDK72299.1 - 5.1e-06 26.3 5.2 5.1e-06 26.3 5.2 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 VDK72299.1 - 2.5e-05 23.9 2.0 2.5e-05 23.9 2.0 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 VDK72299.1 - 3.4e-05 23.7 5.2 3.4e-05 23.7 5.2 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 VDK72299.1 - 8.1e-05 22.6 2.5 8.1e-05 22.6 2.5 2.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK72299.1 - 0.00017 21.4 13.8 0.00018 21.3 4.5 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SHE3 PF17078.5 VDK72299.1 - 0.0031 17.3 15.3 0.0031 17.3 15.3 3.1 2 1 1 3 3 3 2 SWI5-dependent HO expression protein 3 Prok-RING_4 PF14447.6 VDK72299.1 - 0.0037 17.1 5.4 0.0037 17.1 5.4 2.5 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3H2C3 PF17122.5 VDK72299.1 - 0.012 15.6 4.1 0.046 13.8 4.1 2.1 1 0 0 1 1 1 0 Zinc-finger zf-ANAPC11 PF12861.7 VDK72299.1 - 0.027 14.5 6.0 0.025 14.6 4.2 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger GAS PF13851.6 VDK72299.1 - 0.2 11.0 29.6 0.036 13.4 17.9 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding zf-RING_6 PF14835.6 VDK72299.1 - 0.32 10.9 5.7 0.2 11.6 3.4 1.8 1 1 0 1 1 1 0 zf-RING of BARD1-type protein CorA PF01544.18 VDK72299.1 - 0.38 10.0 8.5 0.75 9.1 8.5 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein RecR PF02132.15 VDK72299.1 - 1.9 8.2 10.6 1.7 8.3 1.2 4.1 4 0 0 4 4 4 0 RecR protein Zn_ribbon_17 PF17120.5 VDK72299.1 - 2.8 7.6 15.1 0.067 12.8 5.6 2.6 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type TerY_C PF15616.6 VDK72299.1 - 9.1 6.4 14.0 10 6.3 3.3 2.8 1 1 1 2 2 2 0 TerY-C metal binding domain Sporozoite_P67 PF05642.11 VDK72302.1 - 0.2 9.7 3.0 0.21 9.6 3.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 VDK72302.1 - 0.94 7.5 5.8 0.96 7.5 5.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF148 PF02520.17 VDK72303.1 - 4.7e-10 39.6 2.1 5.8e-10 39.2 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF148 FAM184 PF15665.5 VDK72303.1 - 0.00052 19.9 3.0 0.00061 19.6 3.0 1.0 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B MRP-63 PF14978.6 VDK72303.1 - 0.0019 18.8 0.7 0.004 17.7 0.7 1.6 1 0 0 1 1 1 1 Mitochondrial ribosome protein 63 Lipase_chap PF03280.14 VDK72303.1 - 0.029 14.3 3.8 0.22 11.5 3.8 2.0 1 1 0 1 1 1 0 Proteobacterial lipase chaperone protein DUF3016 PF11454.8 VDK72303.1 - 0.034 13.9 0.1 0.11 12.3 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3016) DUF4413 PF14372.6 VDK72303.1 - 0.051 13.9 0.0 0.074 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4413) GlutR_dimer PF00745.20 VDK72303.1 - 0.35 11.3 4.0 0.57 10.7 1.5 2.2 1 1 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF148 PF02520.17 VDK72304.1 - 1.2e-08 35.0 4.9 1.8e-08 34.5 4.9 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF148 Lipase_chap PF03280.14 VDK72304.1 - 0.0031 17.5 5.4 0.007 16.3 4.3 2.0 1 1 0 1 1 1 1 Proteobacterial lipase chaperone protein Apolipoprotein PF01442.18 VDK72304.1 - 0.0059 16.5 2.9 0.026 14.4 2.9 1.8 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain MHB PF16525.5 VDK72304.1 - 0.094 13.0 0.6 1.4 9.2 0.2 2.4 2 2 0 2 2 2 0 Haemophore, haem-binding DUF148 PF02520.17 VDK72305.1 - 5.1e-13 49.1 7.8 5.1e-13 49.1 7.8 2.0 2 0 0 2 2 2 1 Domain of unknown function DUF148 Lipase_chap PF03280.14 VDK72305.1 - 0.00083 19.4 1.3 0.00083 19.4 1.3 2.7 1 1 1 2 2 2 1 Proteobacterial lipase chaperone protein AAA_32 PF13654.6 VDK72305.1 - 0.0029 16.5 5.3 0.0029 16.5 5.3 1.4 2 0 0 2 2 2 1 AAA domain Peripla_BP_2 PF01497.18 VDK72305.1 - 0.0099 15.5 4.2 0.013 15.1 4.2 1.4 1 1 0 1 1 1 1 Periplasmic binding protein DUF5061 PF16587.5 VDK72305.1 - 0.03 14.4 3.8 0.047 13.8 0.9 2.4 1 1 1 2 2 2 0 17 kDa common-antigen outer membrane protein IER PF05760.12 VDK72305.1 - 0.061 13.6 7.4 0.072 13.4 7.4 1.0 1 0 0 1 1 1 0 Immediate early response protein (IER) Njmu-R1 PF15053.6 VDK72305.1 - 0.083 12.0 3.1 0.051 12.7 0.8 1.6 1 1 1 2 2 2 0 Mjmu-R1-like protein family NRN1 PF15056.6 VDK72305.1 - 0.12 12.5 1.4 0.51 10.5 0.1 2.2 2 0 0 2 2 2 0 Neuritin protein family Cons_hypoth698 PF03601.14 VDK72305.1 - 0.15 10.9 0.2 0.24 10.3 0.2 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 698 SAS-6_N PF16531.5 VDK72305.1 - 1.5 9.5 4.9 0.29 11.7 0.5 2.1 2 1 0 2 2 2 0 Centriolar protein SAS N-terminal AA_permease_2 PF13520.6 VDK72307.1 - 1.5e-08 33.9 41.3 3.8e-08 32.6 27.8 2.8 2 1 0 2 2 2 2 Amino acid permease AA_permease PF00324.21 VDK72307.1 - 4e-06 25.7 22.8 4e-06 25.7 22.8 3.3 2 2 0 2 2 2 1 Amino acid permease AA_permease_C PF13906.6 VDK72307.1 - 0.0014 18.6 3.3 0.0014 18.6 3.3 3.5 3 0 0 3 3 3 1 C-terminus of AA_permease SdpI PF13630.6 VDK72307.1 - 0.3 11.2 0.0 0.3 11.2 0.0 5.3 5 0 0 5 5 5 0 SdpI/YhfL protein family Pkinase_Tyr PF07714.17 VDK72310.1 - 1e-87 293.7 0.0 1.4e-87 293.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK72310.1 - 6.7e-39 133.8 0.0 1e-38 133.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kringle PF00051.18 VDK72310.1 - 2.9e-17 62.7 7.8 7.6e-17 61.4 7.8 1.8 1 0 0 1 1 1 1 Kringle domain Fz PF01392.22 VDK72310.1 - 3.5e-05 24.4 2.1 3.5e-05 24.4 2.1 2.1 2 0 0 2 2 2 1 Fz domain Orthoreo_P10 PF07204.11 VDK72310.1 - 0.11 12.5 2.1 0.87 9.6 1.1 2.6 1 1 1 2 2 2 0 Orthoreovirus membrane fusion protein p10 Kinase-like PF14531.6 VDK72310.1 - 0.14 11.5 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like I-set PF07679.16 VDK72312.1 - 3.8e-18 65.3 0.0 4.6e-18 65.1 0.0 1.0 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK72312.1 - 7.1e-15 55.4 0.0 8.4e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 VDK72312.1 - 2.6e-11 43.5 0.0 3.1e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 VDK72312.1 - 5.9e-09 36.1 0.0 7.2e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 VDK72312.1 - 0.00011 22.4 0.2 0.0052 16.9 0.2 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain Ig_5 PF16681.5 VDK72312.1 - 0.0013 19.1 0.0 0.0028 18.0 0.0 1.5 1 1 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_6 PF18452.1 VDK72312.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Immunoglobulin domain Ig_C17orf99 PF17736.1 VDK72312.1 - 0.15 12.2 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 C17orf99 Ig domain Peptidase_M16_C PF05193.21 VDK72365.1 - 3.3e-20 72.9 0.2 2.5e-11 43.9 0.0 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain NHL PF01436.21 VDK72365.1 - 1.2e-18 66.1 8.1 4.5e-07 29.6 0.1 4.2 3 0 0 3 3 3 3 NHL repeat Peptidase_M16 PF00675.20 VDK72365.1 - 8.2e-10 38.9 1.1 2e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) zf-B_box PF00643.24 VDK72365.1 - 6.5e-08 32.6 17.7 2.2e-06 27.7 5.3 4.7 5 0 0 5 5 5 2 B-box zinc finger zf-RING_UBOX PF13445.6 VDK72365.1 - 1.9e-05 24.6 0.6 1.9e-05 24.6 0.6 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 VDK72365.1 - 0.00029 20.7 0.8 0.00029 20.7 0.8 3.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK72365.1 - 0.0057 16.5 1.1 0.0057 16.5 1.1 4.5 5 0 0 5 5 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK72365.1 - 0.0073 16.1 1.9 0.0073 16.1 1.9 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF5128 PF17170.4 VDK72365.1 - 0.038 13.1 0.3 0.32 10.1 0.1 2.5 3 0 0 3 3 3 0 6-bladed beta-propeller Baculo_PEP_C PF04513.12 VDK72365.1 - 0.52 10.4 3.1 1.3 9.1 0.4 2.8 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus zf-ribbon_3 PF13248.6 VDK72365.1 - 3.7 7.1 6.1 1.9 8.0 0.1 3.5 3 0 0 3 3 3 0 zinc-ribbon domain ORC4_C PF14629.6 VDK72367.1 - 2.5e-07 30.3 2.3 3.9e-07 29.7 2.3 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 VDK72367.1 - 0.00048 20.5 0.1 0.002 18.6 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain RAMP PF04901.13 VDK72367.1 - 0.0083 16.1 0.5 0.022 14.7 0.5 1.7 1 0 0 1 1 1 1 Receptor activity modifying family DUF815 PF05673.13 VDK72367.1 - 0.017 14.3 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) dCMP_cyt_deam_1 PF00383.23 VDK72368.1 - 1.2e-11 44.4 0.1 2.1e-11 43.6 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 VDK72368.1 - 1.6e-05 24.7 0.0 3.8e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 VDK72368.1 - 0.11 12.6 0.3 0.26 11.4 0.3 1.7 1 1 0 1 1 1 0 Bd3614-like deaminase APOBEC3 PF18771.1 VDK72368.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 APOBEC3 AMP-binding PF00501.28 VDK72369.1 - 2.1e-29 102.4 0.8 2.7e-28 98.7 0.8 2.5 1 1 0 1 1 1 1 AMP-binding enzyme PQQ PF01011.21 VDK72369.1 - 3.3e-18 64.6 0.0 1.1e-08 34.6 0.0 5.7 6 0 0 6 6 6 3 PQQ enzyme repeat PQQ_3 PF13570.6 VDK72369.1 - 7.8e-17 61.2 0.0 0.0033 17.9 0.0 6.8 7 0 0 7 7 7 3 PQQ-like domain PQQ_2 PF13360.6 VDK72369.1 - 1.3e-14 54.4 0.0 1.1e-06 28.4 0.0 2.6 1 1 0 2 2 2 2 PQQ-like domain PP-binding PF00550.25 VDK72369.1 - 0.05 14.0 0.1 0.62 10.5 0.1 2.4 1 1 1 2 2 2 0 Phosphopantetheine attachment site DUF5050 PF16472.5 VDK72369.1 - 0.11 11.7 0.0 0.4 9.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5050) Ets PF00178.22 VDK72370.1 - 2.2e-32 111.3 1.0 4.7e-32 110.3 1.0 1.6 1 0 0 1 1 1 1 Ets-domain Sulfatase PF00884.23 VDK72370.1 - 5.3 6.3 8.1 1.7 7.9 0.0 2.9 4 0 0 4 4 4 0 Sulfatase NHL PF01436.21 VDK72371.1 - 9.3e-23 79.1 6.4 8.3e-10 38.2 0.0 3.7 4 0 0 4 4 4 3 NHL repeat DUF5128 PF17170.4 VDK72371.1 - 3.2e-10 39.7 4.8 6.9e-05 22.2 0.2 2.7 1 1 2 3 3 3 3 6-bladed beta-propeller TolB_like PF15869.5 VDK72371.1 - 1.2e-06 28.1 0.0 6.3e-05 22.4 0.0 2.0 1 1 1 2 2 2 2 TolB-like 6-blade propeller-like SGL PF08450.12 VDK72371.1 - 1.3e-05 24.9 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 VDK72371.1 - 0.00035 20.5 0.4 0.027 14.5 0.0 2.8 2 1 0 2 2 2 1 Beta-propeller repeat Lactonase PF10282.9 VDK72371.1 - 0.032 13.5 0.1 0.099 11.9 0.1 1.6 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller MRJP PF03022.16 VDK72371.1 - 0.065 12.6 0.1 0.47 9.8 0.0 1.9 1 1 0 2 2 2 0 Major royal jelly protein Str_synth PF03088.16 VDK72371.1 - 0.088 12.9 0.0 10 6.3 0.0 2.3 2 0 0 2 2 2 0 Strictosidine synthase Arylesterase PF01731.20 VDK72371.1 - 0.12 12.6 0.2 16 5.8 0.0 2.2 1 1 1 2 2 2 0 Arylesterase NHL PF01436.21 VDK72372.1 - 4.5e-17 61.1 5.9 6.1e-06 26.0 0.1 4.1 4 0 0 4 4 4 3 NHL repeat zf-C3HC4 PF00097.25 VDK72372.1 - 1.4e-05 24.9 6.9 1.4e-05 24.9 6.9 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK72372.1 - 0.0019 18.1 6.8 0.0019 18.1 6.8 2.6 2 1 0 2 2 2 1 zinc-RING finger domain DUF5128 PF17170.4 VDK72372.1 - 0.0029 16.8 0.1 0.28 10.3 0.0 2.3 1 1 1 2 2 2 2 6-bladed beta-propeller zf-RING_UBOX PF13445.6 VDK72372.1 - 0.0059 16.6 6.3 0.0059 16.6 6.3 2.4 2 0 0 2 2 2 1 RING-type zinc-finger SRP9-21 PF05486.12 VDK72373.1 - 9.7e-10 38.7 1.9 1.5e-08 34.9 1.9 2.3 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) zf-C2H2 PF00096.26 VDK72374.1 - 3.3e-18 65.0 24.5 0.00048 20.4 0.5 6.3 6 0 0 6 6 6 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK72374.1 - 1.1e-13 50.9 14.1 5.5e-07 29.7 0.9 5.0 4 0 0 4 4 4 3 Zinc-finger double domain FOXP-CC PF16159.5 VDK72374.1 - 3.9e-07 30.6 11.7 0.17 12.6 0.2 5.7 1 1 4 5 5 5 3 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 VDK72374.1 - 5.9e-07 29.8 21.4 0.11 13.4 0.3 6.1 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 VDK72374.1 - 0.0016 18.2 1.0 0.46 10.3 0.1 3.1 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 VDK72374.1 - 0.0032 17.6 8.5 0.29 11.3 1.0 3.7 2 1 0 3 3 3 1 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 VDK72374.1 - 0.0062 16.8 6.7 15 6.0 0.1 4.8 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 VDK72374.1 - 0.29 10.9 5.6 5 7.0 0.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Big_1 PF02369.16 VDK72374.1 - 0.97 9.5 6.8 3 7.9 1.1 3.0 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) zf-met PF12874.7 VDK72374.1 - 1.4 9.5 4.9 48 4.5 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf_Hakai PF18408.1 VDK72374.1 - 2.5 7.9 8.0 5.8 6.7 0.1 4.2 4 0 0 4 4 4 0 C2H2 Hakai zinc finger domain zf-TRAF PF02176.18 VDK72374.1 - 9.5 7.0 9.3 7.1 7.4 1.4 3.3 2 1 0 2 2 2 0 TRAF-type zinc finger FmiP_Thoc5 PF09766.9 VDK72376.1 - 3.7e-81 273.2 0.0 5.5e-81 272.7 0.0 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 DUF4831 PF16115.5 VDK72376.1 - 0.078 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4831) DUF3037 PF11236.8 VDK72376.1 - 0.13 12.7 2.7 1.3 9.4 0.0 3.6 2 1 1 4 4 4 0 Protein of unknown function (DUF3037) HEPN_Apea PF18739.1 VDK72376.1 - 1.3 9.5 5.6 5.6 7.5 5.6 2.2 1 1 0 1 1 1 0 Apea-like HEPN ERM PF00769.19 VDK72377.1 - 9e-26 91.2 2.6 2.8e-25 89.6 2.6 1.7 1 1 0 1 1 1 1 Ezrin/radixin/moesin family BicD PF09730.9 VDK72377.1 - 0.021 13.3 2.4 0.026 12.9 2.4 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D SIMPL PF04402.14 VDK72377.1 - 0.049 14.1 0.3 0.061 13.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF541) Fzo_mitofusin PF04799.13 VDK72377.1 - 0.2 11.2 0.9 0.28 10.7 0.9 1.2 1 0 0 1 1 1 0 fzo-like conserved region FERM_C PF09380.10 VDK72378.1 - 3.4e-21 75.4 0.0 7.9e-21 74.3 0.0 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 VDK72378.1 - 1.8e-20 73.5 1.5 1.8e-20 73.5 1.5 2.4 2 1 1 3 3 3 1 FERM central domain FERM_N PF09379.10 VDK72378.1 - 7.7e-15 54.6 0.0 2.3e-14 53.1 0.0 1.9 2 0 0 2 2 2 1 FERM N-terminal domain ERM PF00769.19 VDK72378.1 - 1.4e-08 34.9 16.9 1.4e-08 34.9 16.9 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family ACBP PF00887.19 VDK72378.1 - 0.066 13.4 0.4 0.45 10.8 0.1 2.5 2 1 0 2 2 2 0 Acyl CoA binding protein DUF4011 PF13195.6 VDK72378.1 - 0.26 11.2 6.0 0.52 10.2 6.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) FapA PF03961.13 VDK72378.1 - 0.34 9.5 8.8 0.48 9.0 8.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 VDK72378.1 - 0.74 7.6 9.5 1 7.2 9.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Asp-B-Hydro_N PF05279.11 VDK72378.1 - 2.7 8.0 12.6 4.9 7.2 12.6 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF724 PF05266.14 VDK72378.1 - 5.8 6.7 15.0 15 5.4 15.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HAUS6_N PF14661.6 VDK72378.1 - 8.2 5.9 13.8 17 4.9 13.8 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus PGM_PMM_II PF02879.16 VDK72381.1 - 6.4e-14 52.4 0.1 1.2e-13 51.6 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 VDK72381.1 - 1.3e-11 44.7 0.0 1.9e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 VDK72381.1 - 4e-08 33.3 0.0 8e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain NADH_B2 PF14813.6 VDK72381.1 - 0.085 12.7 2.4 0.21 11.4 2.4 1.6 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 VPS9 PF02204.18 VDK72403.1 - 5.5e-11 42.6 0.0 9.7e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain RA PF00788.23 VDK72403.1 - 0.0012 19.5 0.0 0.0028 18.3 0.0 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain DUF2591 PF10765.9 VDK72403.1 - 0.094 13.0 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) EF_TS PF00889.19 VDK72404.1 - 1.5e-26 93.3 0.0 2.2e-26 92.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor TS Linker_histone PF00538.19 VDK72404.1 - 0.0017 18.7 0.2 3.7 8.0 0.0 2.9 3 0 0 3 3 3 2 linker histone H1 and H5 family Neur_chan_LBD PF02931.23 VDK72407.1 - 2.4e-14 53.3 0.2 2.8e-14 53.1 0.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF5344 PF17279.2 VDK72407.1 - 0.13 12.9 0.7 1.6 9.3 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5344) Condensation PF00668.20 VDK72408.1 - 4.6e-117 391.5 33.4 5.8e-50 170.3 2.5 7.6 6 3 0 6 6 6 6 Condensation domain AMP-binding PF00501.28 VDK72408.1 - 8e-110 367.3 0.0 3.5e-60 203.8 0.1 2.2 2 0 0 2 2 2 2 AMP-binding enzyme PP-binding PF00550.25 VDK72408.1 - 2.2e-40 136.8 0.1 1.5e-07 31.7 0.0 5.8 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 VDK72408.1 - 1.1e-19 71.2 0.0 2e-08 35.1 0.0 3.0 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain Thioesterase PF00975.20 VDK72408.1 - 1.6e-06 28.4 0.0 3.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain DUF1706 PF08020.11 VDK72408.1 - 0.091 12.7 0.1 11 5.9 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1706) Ist1 PF03398.14 VDK72409.1 - 2.7e-60 203.0 2.4 3.6e-60 202.6 2.4 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway OB_NTP_bind PF07717.16 VDK72410.1 - 2.6e-26 91.8 0.0 6.2e-26 90.6 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 VDK72410.1 - 2.8e-23 82.3 0.1 2.8e-23 82.3 0.1 2.8 3 1 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 VDK72410.1 - 3.1e-14 53.3 0.0 1.4e-13 51.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain S1 PF00575.23 VDK72410.1 - 1.2e-12 48.0 0.4 3.5e-12 46.5 0.4 1.9 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 VDK72410.1 - 0.00011 22.0 0.1 0.00026 20.8 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 VDK72410.1 - 0.00016 22.1 0.2 0.00037 20.8 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 VDK72410.1 - 0.00034 20.4 0.1 0.00067 19.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 VDK72410.1 - 0.00079 18.6 0.3 0.0032 16.6 0.1 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 VDK72410.1 - 0.0013 19.0 0.1 0.0054 17.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 VDK72410.1 - 0.0099 15.9 0.1 0.02 14.9 0.1 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_16 PF13191.6 VDK72410.1 - 0.084 13.2 0.0 0.26 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_11 PF13086.6 VDK72410.1 - 3.9 7.2 7.2 12 5.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Galactosyl_T PF01762.21 VDK72411.1 - 1.2e-33 116.5 0.0 1.5e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase EF-hand_1 PF00036.32 VDK72413.1 - 7.5e-18 62.7 13.9 5.1e-06 25.7 0.6 4.4 3 1 1 4 4 4 4 EF hand EF-hand_6 PF13405.6 VDK72413.1 - 1.3e-16 59.0 10.2 2.8e-05 23.7 0.2 4.6 3 2 2 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 VDK72413.1 - 9.8e-15 54.8 6.6 1.1e-06 28.9 0.5 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK72413.1 - 2.9e-13 48.7 14.3 9.2e-05 21.8 0.1 4.6 3 2 1 4 4 4 4 EF hand EF-hand_8 PF13833.6 VDK72413.1 - 7.6e-08 32.1 8.9 0.0036 17.1 0.0 4.0 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 VDK72413.1 - 0.06 13.7 0.0 8.5 6.7 0.0 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 VDK72413.1 - 1.1 9.1 5.3 42 4.0 0.1 3.6 1 1 3 4 4 4 0 Caleosin related protein NTP_transf_2 PF01909.23 VDK72415.1 - 0.0018 18.5 0.0 0.0049 17.1 0.0 1.8 1 1 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 VDK72415.1 - 0.059 13.5 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Collagen PF01391.18 VDK72417.1 - 2.5e-25 88.0 112.4 2.2e-09 36.9 37.0 4.1 2 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) PIRT PF15099.6 VDK72419.1 - 0.0018 17.8 0.6 0.0023 17.5 0.6 1.2 1 0 0 1 1 1 1 Phosphoinositide-interacting protein family DUF3040 PF11239.8 VDK72419.1 - 0.17 12.2 0.5 0.25 11.6 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Tom6 PF17112.5 VDK72419.1 - 0.31 10.6 1.8 1.1 8.9 1.8 1.9 1 1 0 1 1 1 0 Mitochondrial import receptor subunit Tom6, fungal DUF202 PF02656.15 VDK72419.1 - 0.82 10.2 3.1 4.6 7.8 3.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF202) PDZ PF00595.24 VDK72421.1 - 7e-12 45.5 10.4 1.3e-06 28.7 0.2 3.1 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 VDK72421.1 - 3.3e-11 43.4 0.2 0.00014 22.1 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK72421.1 - 4.1e-11 42.6 1.9 5.2e-05 23.0 0.3 2.6 2 0 0 2 2 2 2 PDZ domain PARP PF00644.20 VDK72423.1 - 5.5e-66 221.9 0.0 1.1e-65 220.9 0.0 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 VDK72423.1 - 1.7e-40 138.3 2.5 4.9e-40 136.8 2.5 1.9 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain Aha1_N PF09229.11 VDK72423.1 - 1.3e-33 116.1 0.2 3.8e-33 114.6 0.2 1.9 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal zf-PARP PF00645.18 VDK72423.1 - 1.3e-32 112.4 10.9 3.7e-17 63.0 0.7 3.4 3 0 0 3 3 3 2 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WGR PF05406.15 VDK72423.1 - 1.7e-19 69.7 2.5 3.9e-19 68.5 2.5 1.7 1 0 0 1 1 1 1 WGR domain PADR1 PF08063.12 VDK72423.1 - 3.3e-17 62.0 4.5 3.3e-17 62.0 4.5 2.0 2 0 0 2 2 2 1 PADR1 (NUC008) domain AHSA1 PF08327.11 VDK72423.1 - 1.9e-15 57.2 0.0 5.1e-15 55.8 0.0 1.8 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DUF2175 PF09943.9 VDK72423.1 - 3.5 8.0 7.9 4.4 7.6 1.3 3.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) LIM PF00412.22 VDK72423.1 - 5.8 7.2 9.2 0.17 12.2 0.4 2.8 3 1 0 3 3 3 0 LIM domain IFP_35_N PF07334.13 VDK72426.1 - 0.1 12.7 3.3 0.5 10.5 0.1 2.5 2 2 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Presenilin PF01080.17 VDK72427.1 - 8.5 5.0 4.9 9.2 4.9 4.9 1.1 1 0 0 1 1 1 0 Presenilin Rhodanese PF00581.20 VDK72428.1 - 9.6e-16 58.2 0.0 7.8e-12 45.7 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Sacchrp_dh_NADP PF03435.18 VDK72429.1 - 2.5e-18 66.6 0.1 4.1e-18 65.9 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 VDK72429.1 - 0.098 12.0 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Enolase_C PF00113.22 VDK72466.1 - 1.9e-151 503.4 0.1 2.4e-151 503.0 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 VDK72466.1 - 2.8e-58 195.8 0.0 5e-58 194.9 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 VDK72466.1 - 2.3e-05 24.1 0.0 3.5e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 VDK72466.1 - 5e-05 22.6 0.4 0.00013 21.2 0.4 1.7 1 1 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Pkinase PF00069.25 VDK72467.1 - 5.7e-27 94.7 0.1 7.2e-27 94.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK72467.1 - 1.2e-17 64.1 0.1 1.4e-17 63.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK72467.1 - 0.0012 17.7 0.0 0.0021 16.9 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK72467.1 - 0.003 17.5 0.0 0.097 12.6 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 VDK72467.1 - 0.0076 15.6 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HTH_27 PF13463.6 VDK72467.1 - 0.054 14.0 0.0 0.22 12.1 0.0 2.0 2 0 0 2 2 2 0 Winged helix DNA-binding domain rRNA_proc-arch PF13234.6 VDK72468.1 - 3.8e-68 230.3 5.6 7.7e-68 229.3 5.6 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 VDK72468.1 - 4.3e-53 179.4 0.3 8.5e-53 178.4 0.3 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 VDK72468.1 - 2.1e-20 73.2 0.1 8.3e-18 64.8 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK72468.1 - 2.2e-05 24.7 0.0 0.00016 22.0 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain BAR_3 PF16746.5 VDK72468.1 - 0.0055 16.4 1.6 0.022 14.5 1.6 2.0 1 0 0 1 1 1 1 BAR domain of APPL family UPF0449 PF15136.6 VDK72468.1 - 0.08 13.4 1.7 0.35 11.3 1.7 2.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 NUDE_C PF04880.13 VDK72468.1 - 0.54 10.7 3.1 7.4 7.0 0.5 2.6 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region HalX PF08663.10 VDK72468.1 - 0.65 10.4 6.5 4.1 7.8 0.1 3.8 3 0 0 3 3 3 0 HalX domain CD20 PF04103.15 VDK72469.1 - 0.00013 22.1 7.1 0.00013 22.1 7.1 2.2 1 1 1 2 2 2 1 CD20-like family DUF308 PF03729.13 VDK72469.1 - 0.00028 21.1 5.9 0.00028 21.1 5.9 2.2 2 0 0 2 2 2 1 Short repeat of unknown function (DUF308) BCLP PF12304.8 VDK72469.1 - 0.0064 16.1 0.8 0.0064 16.1 0.8 2.0 1 1 1 2 2 2 1 Beta-casein like protein TMEM100 PF16311.5 VDK72469.1 - 0.068 12.8 3.8 0.45 10.1 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 100 7TMR-DISM_7TM PF07695.11 VDK72469.1 - 0.089 12.7 12.0 0.031 14.2 9.4 1.6 1 1 1 2 2 2 0 7TM diverse intracellular signalling TMEM43 PF07787.12 VDK72469.1 - 0.98 8.8 10.5 1.5e+02 1.6 10.5 2.1 1 1 0 1 1 1 0 Transmembrane protein 43 ABC2_membrane_3 PF12698.7 VDK72469.1 - 1.7 7.7 10.2 2.1 7.4 10.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein MCPVI PF02993.14 VDK72471.1 - 0.073 12.9 0.1 0.073 12.9 0.1 2.8 3 0 0 3 3 3 0 Minor capsid protein VI zf-PHD-like PF15446.6 VDK72471.1 - 0.53 9.9 7.2 0.26 10.9 1.7 3.0 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain PHD PF00628.29 VDK72471.1 - 1.6 8.7 13.3 1.3 9.0 10.5 2.2 2 0 0 2 2 2 0 PHD-finger Ank_2 PF12796.7 VDK72475.1 - 5.2e-30 103.9 5.5 1.1e-09 38.8 0.2 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK72475.1 - 3e-26 91.4 1.9 4.7e-13 49.4 0.1 6.2 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK72475.1 - 5.5e-24 81.6 3.4 0.00097 19.4 0.0 6.2 5 0 0 5 5 5 5 Ankyrin repeat Ank PF00023.30 VDK72475.1 - 3.3e-23 81.1 5.2 1.1e-05 25.6 0.0 6.9 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 VDK72475.1 - 4.4e-23 81.0 7.5 1.5e-08 34.8 0.2 6.2 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Notch PF00066.17 VDK72475.1 - 6.6e-23 80.9 45.4 6.4e-10 39.3 12.5 7.6 7 1 0 7 7 5 3 LNR domain EGF PF00008.27 VDK72475.1 - 4.6e-12 46.0 83.6 2.1e-06 27.9 8.9 7.9 7 1 0 7 7 5 4 EGF-like domain hEGF PF12661.7 VDK72475.1 - 8.4e-09 35.7 62.5 0.00074 20.1 7.9 7.8 6 0 0 6 6 6 4 Human growth factor-like EGF EGF_CA PF07645.15 VDK72475.1 - 1.7e-06 28.1 11.8 1.7e-06 28.1 11.8 7.8 7 2 2 9 9 6 1 Calcium-binding EGF domain NODP PF07684.12 VDK72475.1 - 0.00035 20.7 0.0 0.00035 20.7 0.0 3.4 5 0 0 5 5 3 1 NOTCH protein NOD PF06816.13 VDK72475.1 - 0.0077 15.8 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 NOTCH protein EGF_2 PF07974.13 VDK72475.1 - 0.0082 16.5 12.7 0.0082 16.5 12.7 7.6 7 1 0 7 7 5 2 EGF-like domain Viral_DNA_Zn_bi PF03728.13 VDK72481.1 - 0.027 15.0 0.0 0.083 13.5 0.0 1.8 2 0 0 2 2 2 0 Viral DNA-binding protein, zinc binding domain ASF1_hist_chap PF04729.13 VDK72482.1 - 1.8e-62 209.9 0.0 2.4e-62 209.4 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone UPF0449 PF15136.6 VDK72482.1 - 0.073 13.6 1.6 0.14 12.7 1.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 EBP PF05241.12 VDK72486.1 - 5.8e-08 32.4 6.6 7e-08 32.1 6.6 1.0 1 0 0 1 1 1 1 Emopamil binding protein 7tm_1 PF00001.21 VDK72515.1 - 1e-25 90.6 15.6 1.3e-25 90.2 15.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 VDK72515.1 - 0.0027 17.5 4.2 0.0043 16.8 4.2 1.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 VDK72515.1 - 0.026 14.2 15.0 0.062 12.9 15.0 1.5 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx EcoR124_C PF12008.8 VDK72516.1 - 0.053 13.2 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal DUF3361 PF11841.8 VDK72516.1 - 0.067 13.1 0.1 0.15 12.0 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3361) DUF4070 PF13282.6 VDK72516.1 - 0.089 12.9 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4070) FKBP_C PF00254.28 VDK72518.1 - 1.1e-51 173.1 0.0 3.8e-26 91.3 0.0 2.2 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase His_Phos_2 PF00328.22 VDK72520.1 - 1.1e-05 25.0 0.0 0.00031 20.2 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) zf-C4 PF00105.18 VDK72525.1 - 3.6e-06 27.3 0.8 3.6e-06 27.3 0.8 1.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Miga PF10265.9 VDK72525.1 - 1.5 7.7 4.3 1.8 7.4 4.3 1.2 1 0 0 1 1 1 0 Mitoguardin zf-C4 PF00105.18 VDK72526.1 - 2.5e-16 59.9 12.6 2.6e-15 56.6 10.2 2.4 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK72526.1 - 6.4e-13 48.8 0.4 1.7e-12 47.4 0.4 1.6 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Calponin PF00402.18 VDK72527.1 - 1.6e-28 97.9 26.8 2.1e-10 40.0 0.4 6.0 5 1 1 6 6 6 5 Calponin family repeat FAM60A PF15396.6 VDK72527.1 - 0.39 10.7 4.1 0.73 9.8 4.1 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Vfa1 PF08432.10 VDK72527.1 - 0.86 9.9 14.2 1.3 9.3 14.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 BUD22 PF09073.10 VDK72527.1 - 8.3 5.6 28.0 10 5.3 28.0 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 VDK72527.1 - 9.6 5.5 34.1 12 5.1 34.1 1.2 1 0 0 1 1 1 0 SDA1 Ribosomal_L29 PF00831.23 VDK72528.1 - 1.6e-18 66.4 1.5 1.6e-18 66.4 1.5 2.5 2 1 0 2 2 2 1 Ribosomal L29 protein SNCAIP_SNCA_bd PF16700.5 VDK72528.1 - 0.041 13.6 0.3 0.12 12.1 0.3 1.8 1 0 0 1 1 1 0 Synphilin-1 alpha-Synuclein-binding domain NPV_P10 PF05531.12 VDK72528.1 - 0.11 13.0 2.1 0.35 11.3 1.1 2.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.6 VDK72528.1 - 0.4 11.1 8.2 0.078 13.4 2.5 2.1 1 1 1 2 2 2 0 Snapin/Pallidin Chromo PF00385.24 VDK72529.1 - 1e-14 54.2 3.2 1e-14 54.2 3.2 2.8 3 1 1 4 4 4 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 VDK72529.1 - 1.4e-06 28.2 0.3 1.7e-05 24.8 0.1 2.4 2 0 0 2 2 2 1 Chromo shadow domain tRNA-synt_1 PF00133.22 VDK72530.1 - 1e-197 658.1 0.0 2.2e-196 653.8 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 VDK72530.1 - 9.4e-40 136.0 0.0 2.5e-39 134.7 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 VDK72530.1 - 6e-14 51.6 0.1 7e-06 25.0 0.0 4.5 5 0 0 5 5 5 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 VDK72530.1 - 8.9e-10 38.4 3.3 6.4e-08 32.3 0.0 3.1 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 VDK72530.1 - 0.0036 16.7 0.0 0.03 13.7 0.1 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain FtsJ PF01728.19 VDK72532.1 - 1.1e-19 71.2 0.0 2.4e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltrans_Mon PF14314.6 VDK72532.1 - 0.00038 18.7 0.1 0.00058 18.0 0.1 1.2 1 0 0 1 1 1 1 Virus-capping methyltransferase DUF973 PF06157.11 VDK72535.1 - 4.7 6.2 12.2 0.27 10.3 6.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF973) His_Phos_2 PF00328.22 VDK72536.1 - 1.1e-15 57.9 0.1 4.2e-15 56.0 0.1 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Glutaredoxin2_C PF04399.13 VDK72536.1 - 0.0051 16.6 0.1 0.012 15.5 0.1 1.6 1 0 0 1 1 1 1 Glutaredoxin 2, C terminal domain Maelstrom PF13017.6 VDK72537.1 - 8.7e-22 77.8 1.0 7.5e-17 61.7 0.0 2.4 2 0 0 2 2 2 2 piRNA pathway germ-plasm component HMG_box_2 PF09011.10 VDK72537.1 - 0.031 14.9 0.3 0.13 12.9 0.3 2.0 1 1 0 1 1 1 0 HMG-box domain HMG_box PF00505.19 VDK72537.1 - 4.2 7.9 7.2 5.4 7.5 1.7 3.1 2 1 0 2 2 2 0 HMG (high mobility group) box zf-RING_2 PF13639.6 VDK72538.1 - 8.2e-06 26.1 16.2 8.2e-06 26.1 16.2 4.5 4 1 1 5 5 5 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK72538.1 - 2.8e-05 24.0 14.2 2.8e-05 24.0 14.2 3.2 4 0 0 4 4 4 1 RING-type zinc-finger zf-RING_5 PF14634.6 VDK72538.1 - 0.0003 20.7 14.4 0.0003 20.7 14.4 4.5 3 1 0 3 3 3 1 zinc-RING finger domain zf-C3HC4 PF00097.25 VDK72538.1 - 0.0022 17.8 16.5 0.0022 17.8 16.5 4.2 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Peptidase_S64 PF08192.11 VDK72538.1 - 0.21 10.0 3.4 0.17 10.4 1.5 1.5 1 1 0 2 2 2 0 Peptidase family S64 BRCT_assoc PF12820.7 VDK72538.1 - 0.63 9.8 5.1 0.91 9.3 0.1 2.4 2 0 0 2 2 2 0 Serine-rich domain associated with BRCT ORC5_C PF14630.6 VDK72542.1 - 3.7e-43 148.1 0.1 1.1e-42 146.5 0.1 1.7 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus BAT2_N PF07001.11 VDK72544.1 - 4.9e-21 76.1 14.0 4.9e-21 76.1 14.0 9.0 9 2 2 11 11 11 1 BAT2 N-terminus SRCR PF00530.18 VDK72544.1 - 0.13 12.8 0.6 0.42 11.1 0.6 1.9 1 0 0 1 1 1 0 Scavenger receptor cysteine-rich domain HHV-1_VABD PF16852.5 VDK72544.1 - 0.4 10.7 9.6 0.11 12.6 0.6 4.1 3 0 0 3 3 3 0 Herpes viral adaptor-to-host cellular mRNA binding domain RhoGAP PF00620.27 VDK72562.1 - 3.2e-49 166.6 0.0 6.3e-49 165.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain hEGF PF12661.7 VDK72564.1 - 8e-05 23.1 16.7 0.0038 17.8 4.3 3.1 2 0 0 2 2 2 2 Human growth factor-like EGF DUF2428 PF10350.9 VDK72564.1 - 0.0011 18.3 0.1 0.0037 16.5 0.1 1.9 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) EGF PF00008.27 VDK72564.1 - 0.0015 18.8 18.6 0.049 14.0 6.4 2.8 2 0 0 2 2 2 2 EGF-like domain EGF_2 PF07974.13 VDK72564.1 - 0.0061 16.9 9.6 0.0061 16.9 9.6 3.2 2 0 0 2 2 2 1 EGF-like domain SMP_2 PF10144.9 VDK72564.1 - 0.14 11.8 0.1 0.36 10.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin DEP PF00610.21 VDK72564.1 - 0.15 12.1 0.3 6.9 6.8 0.0 3.4 3 0 0 3 3 3 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) TPR_19 PF14559.6 VDK72565.1 - 2.6e-44 149.6 54.5 0.00022 21.7 0.0 17.2 13 3 5 18 18 18 11 Tetratricopeptide repeat TPR_2 PF07719.17 VDK72565.1 - 4.5e-28 95.1 60.6 0.0002 21.2 0.0 18.8 20 0 0 20 20 19 9 Tetratricopeptide repeat TPR_14 PF13428.6 VDK72565.1 - 8.9e-27 91.5 52.0 0.0071 17.1 0.0 19.4 12 5 9 21 21 20 8 Tetratricopeptide repeat TPR_16 PF13432.6 VDK72565.1 - 1.7e-25 89.4 27.2 0.00049 20.7 0.2 11.9 10 2 2 12 12 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 VDK72565.1 - 1.6e-19 68.4 41.6 0.00023 21.1 0.1 16.0 17 0 0 17 17 16 3 Tetratricopeptide repeat TPR_21 PF09976.9 VDK72565.1 - 3.6e-13 49.7 32.6 6.4e-05 22.7 0.1 7.7 5 4 3 8 8 8 4 Tetratricopeptide repeat-like domain TPR_7 PF13176.6 VDK72565.1 - 8.2e-11 41.2 32.6 0.0044 17.0 0.0 11.7 12 0 0 12 12 12 3 Tetratricopeptide repeat TPR_1 PF00515.28 VDK72565.1 - 7.1e-10 38.3 60.8 0.00023 20.8 0.0 16.5 19 0 0 19 19 19 2 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK72565.1 - 1.1e-08 35.1 61.0 0.0094 16.2 0.6 11.8 9 3 7 16 16 16 7 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 VDK72565.1 - 7.1e-08 32.6 41.0 0.46 11.2 0.1 16.0 18 0 0 18 18 17 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK72565.1 - 3.1e-07 30.6 58.7 0.72 10.2 1.8 16.0 13 6 5 18 18 18 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK72565.1 - 4.9e-06 26.1 35.8 9.1e-05 22.1 0.1 9.4 12 0 0 12 12 10 3 TPR repeat TPR_17 PF13431.6 VDK72565.1 - 0.0058 16.9 21.1 0.09 13.2 1.6 9.2 10 0 0 10 10 9 1 Tetratricopeptide repeat ATP13 PF12921.7 VDK72565.1 - 0.032 14.1 0.0 0.13 12.1 0.0 2.1 1 0 0 1 1 1 0 Mitochondrial ATPase expression TPR_4 PF07721.14 VDK72565.1 - 0.23 12.2 13.4 1.2e+02 3.8 0.1 8.5 10 0 0 10 10 7 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 VDK72565.1 - 0.78 9.6 4.7 2.1 8.2 0.2 3.6 5 0 0 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal TPR_20 PF14561.6 VDK72565.1 - 1.1 9.6 23.0 12 6.3 0.3 8.2 7 2 2 9 9 9 0 Tetratricopeptide repeat RPN7 PF10602.9 VDK72565.1 - 3 7.5 18.0 2.2 8.0 0.3 6.8 5 1 2 7 7 7 0 26S proteasome subunit RPN7 WH1 PF00568.23 VDK72567.1 - 7.3e-06 25.9 0.6 1.2e-05 25.2 0.1 1.5 2 0 0 2 2 2 1 WH1 domain Integrin_alpha2 PF08441.12 VDK72568.1 - 1.5e-96 324.2 1.6 1.8e-96 323.9 1.6 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 VDK72568.1 - 4.5e-29 100.2 34.9 1.1e-08 35.0 8.1 4.7 4 0 0 4 4 4 4 FG-GAP repeat VCBS PF13517.6 VDK72568.1 - 3.3e-15 56.4 32.9 1.1e-06 29.1 3.4 3.6 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Integrin_alpha PF00357.20 VDK72568.1 - 0.00019 21.2 0.4 0.00019 21.2 0.4 2.3 2 0 0 2 2 2 1 Integrin alpha cytoplasmic region FG-GAP_2 PF14312.6 VDK72568.1 - 0.00064 19.9 2.0 0.00064 19.9 2.0 4.4 4 0 0 4 4 4 2 FG-GAP repeat DnaJ PF00226.31 VDK72574.1 - 1.2e-19 70.2 2.1 2.3e-19 69.3 1.4 1.8 2 0 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.31 VDK72574.1 - 1.6e-12 47.4 0.5 1.5e-06 28.3 0.0 3.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 VDK72574.1 - 4.3e-07 30.1 8.3 0.00094 19.4 0.5 4.2 4 0 0 4 4 4 2 Myb-like DNA-binding domain SnAPC_2_like PF11035.8 VDK72574.1 - 0.27 11.3 0.1 0.27 11.3 0.1 2.4 3 0 0 3 3 3 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb Myb_DNA-bind_4 PF13837.6 VDK72574.1 - 6.2 7.3 10.9 11 6.4 1.1 3.9 3 2 0 3 3 3 0 Myb/SANT-like DNA-binding domain EF-hand_7 PF13499.6 VDK72577.1 - 1.4e-16 60.7 5.7 7.6e-07 29.5 0.8 3.3 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 VDK72577.1 - 2e-16 58.2 14.0 0.0001 21.6 0.1 5.4 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 VDK72577.1 - 7.8e-15 53.5 13.9 0.0017 18.1 0.2 5.6 4 1 2 6 6 6 5 EF-hand domain EF-hand_5 PF13202.6 VDK72577.1 - 9e-07 28.1 16.8 0.051 13.1 0.2 5.7 5 1 1 6 6 6 3 EF hand EF-hand_8 PF13833.6 VDK72577.1 - 1.5e-06 28.0 10.2 0.00069 19.4 0.0 4.4 4 1 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 VDK72577.1 - 1.4e-05 25.4 3.9 0.27 11.6 0.2 3.3 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 VDK72577.1 - 0.53 10.3 3.6 0.74 9.8 0.4 2.6 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 VDK72578.1 - 3e-36 120.3 27.7 0.00032 20.0 0.1 11.6 11 0 0 11 11 11 11 EF hand EF-hand_5 PF13202.6 VDK72578.1 - 7.2e-30 101.2 30.8 0.0019 17.6 0.2 11.6 11 0 0 11 11 11 10 EF hand EF-hand_7 PF13499.6 VDK72578.1 - 4.7e-28 97.4 23.0 8.1e-06 26.2 0.0 7.8 2 2 6 9 9 9 8 EF-hand domain pair EF-hand_6 PF13405.6 VDK72578.1 - 1.9e-26 89.7 30.4 0.003 17.4 0.1 11.6 11 0 0 11 11 11 10 EF-hand domain SPARC_Ca_bdg PF10591.9 VDK72578.1 - 1.5e-15 57.5 6.2 0.0003 21.1 0.0 6.0 2 2 0 5 5 5 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 VDK72578.1 - 2e-12 46.8 36.2 0.0031 17.3 0.0 10.1 8 3 3 11 11 11 4 EF-hand domain pair EF-hand_10 PF14788.6 VDK72578.1 - 7.7e-08 32.1 5.1 0.62 10.0 0.0 7.0 7 1 1 8 8 8 2 EF hand Dockerin_1 PF00404.18 VDK72578.1 - 0.043 14.0 20.0 14 6.0 0.3 6.6 7 0 0 7 7 7 0 Dockerin type I domain DUF4629 PF15442.6 VDK72578.1 - 0.61 10.3 16.5 0.05 13.8 10.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4629) PIH1 PF08190.12 VDK72580.1 - 0.0018 17.8 0.1 0.0069 15.9 0.1 2.0 1 0 0 1 1 1 1 PIH1 N-terminal domain FKBP_N PF01346.18 VDK72580.1 - 0.053 14.5 4.3 0.19 12.7 4.3 2.0 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF2252 PF10009.9 VDK72580.1 - 0.29 10.2 3.0 0.52 9.3 3.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Osteopontin PF00865.18 VDK72581.1 - 0.085 12.3 35.5 0.1 12.1 35.5 1.1 1 0 0 1 1 1 0 Osteopontin Vfa1 PF08432.10 VDK72581.1 - 0.12 12.7 4.4 0.14 12.5 4.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2457 PF10446.9 VDK72581.1 - 0.16 11.1 36.2 0.21 10.7 36.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 VDK72581.1 - 0.21 9.8 23.1 0.21 9.8 23.1 1.0 1 0 0 1 1 1 0 Nop14-like family CNDH2_C PF16858.5 VDK72581.1 - 0.21 11.4 9.1 0.25 11.2 9.1 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Mpp10 PF04006.12 VDK72581.1 - 0.38 9.1 16.6 0.38 9.1 16.6 1.1 1 0 0 1 1 1 0 Mpp10 protein CobT PF06213.12 VDK72581.1 - 0.43 9.9 13.9 0.45 9.9 13.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 VDK72581.1 - 0.95 7.5 35.5 1.2 7.2 35.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop25 PF09805.9 VDK72581.1 - 0.97 9.9 10.5 1.2 9.6 10.5 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) TFB6 PF17110.5 VDK72581.1 - 0.98 9.1 10.4 1.2 8.9 10.4 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH IFT57 PF10498.9 VDK72581.1 - 1.1 8.2 7.9 1.2 8.0 7.9 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 BUD22 PF09073.10 VDK72581.1 - 1.5 8.1 17.6 1.6 8.0 17.6 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 VDK72581.1 - 2 6.6 20.3 2.1 6.5 20.3 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 VDK72581.1 - 2.3 7.6 22.9 2.5 7.4 22.9 1.1 1 0 0 1 1 1 0 SDA1 Cnd2 PF05786.14 VDK72581.1 - 3.9 6.0 19.1 4.6 5.8 19.1 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 DUF2722 PF10846.8 VDK72581.1 - 5.8 5.7 16.2 5.9 5.7 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2076 PF09849.9 VDK72581.1 - 9 6.3 27.7 12 5.8 27.7 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2796 PF10986.8 VDK72581.1 - 9.9 6.1 8.8 14 5.6 8.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) MH2 PF03166.14 VDK72582.1 - 1.5e-53 181.8 0.0 3e-53 180.8 0.0 1.5 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 VDK72582.1 - 2e-35 121.1 0.5 5.6e-35 119.7 0.2 1.9 2 0 0 2 2 2 1 MH1 domain DUF1955 PF09205.10 VDK72582.1 - 0.00015 21.6 0.0 0.00027 20.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1955) DUF2890 PF11081.8 VDK72582.1 - 0.053 13.6 0.8 0.12 12.5 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) ARS2 PF04959.13 VDK72582.1 - 0.14 12.5 0.7 1.1 9.6 0.8 2.0 2 0 0 2 2 2 0 Arsenite-resistance protein 2 Ribosomal_L28e PF01778.17 VDK72583.1 - 4.6e-32 111.2 0.4 4.6e-32 111.2 0.4 2.1 3 0 0 3 3 3 1 Ribosomal L28e protein family Mak16 PF04874.14 VDK72583.1 - 5.5e-27 94.3 11.0 5.5e-27 94.3 11.0 2.5 2 1 0 2 2 2 1 Mak16 protein C-terminal region RRN3 PF05327.11 VDK72583.1 - 3.6 6.0 11.5 5.7 5.4 11.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Laminin_G_2 PF02210.24 VDK72597.1 - 8.3e-84 278.5 1.3 5.5e-22 78.7 0.0 5.2 5 0 0 5 5 5 5 Laminin G domain Laminin_G_1 PF00054.23 VDK72597.1 - 4.3e-64 214.6 0.0 1.7e-17 63.9 0.0 5.2 5 0 0 5 5 5 5 Laminin G domain EGF PF00008.27 VDK72597.1 - 8.4e-08 32.4 17.5 0.00033 20.9 3.7 2.6 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 VDK72597.1 - 1.5e-05 25.4 12.1 0.028 15.0 5.8 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF Laminin_G_3 PF13385.6 VDK72597.1 - 0.0021 18.2 0.2 24 5.0 0.0 4.1 4 0 0 4 4 4 1 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 VDK72597.1 - 7.9 7.0 24.5 7.4 7.0 8.4 2.6 2 0 0 2 2 2 0 EGF-like domain Cadherin_C_2 PF16492.5 VDK72599.1 - 0.0048 17.6 2.9 0.012 16.4 0.0 3.0 3 1 0 3 3 3 1 Cadherin cytoplasmic C-terminal Sulf_transp PF04143.14 VDK72599.1 - 1.1 8.8 5.3 21 4.6 3.6 2.1 2 0 0 2 2 2 0 Sulphur transport I-set PF07679.16 VDK72601.1 - 4.5e-61 202.9 0.0 9.2e-21 73.7 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK72601.1 - 7.9e-44 148.1 0.0 7.8e-14 52.0 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 VDK72601.1 - 1.4e-29 102.2 0.0 2e-09 37.6 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 VDK72601.1 - 2.3e-22 79.0 0.1 1.7e-08 34.5 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain V-set PF07686.17 VDK72601.1 - 3.8e-12 46.4 0.2 0.16 12.2 0.0 5.3 3 2 1 4 4 4 4 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK72601.1 - 2.8e-10 40.1 0.0 0.047 13.8 0.0 3.8 4 0 0 4 4 4 3 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 VDK72601.1 - 3.9e-06 27.1 0.0 1.9 8.9 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin C1-set domain Receptor_2B4 PF11465.8 VDK72601.1 - 6.9e-05 23.0 0.0 7 6.9 0.0 3.2 3 0 0 3 3 3 3 Natural killer cell receptor 2B4 Ig_C17orf99 PF17736.1 VDK72601.1 - 0.01 15.9 0.0 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 C17orf99 Ig domain Porin_8 PF16966.5 VDK72601.1 - 0.021 13.8 0.0 0.074 12.0 0.0 1.7 2 0 0 2 2 2 0 Porin-like glycoporin RafY V-set_CD47 PF08204.11 VDK72601.1 - 0.076 13.0 0.5 0.45 10.5 0.0 2.6 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain I-set PF07679.16 VDK72603.1 - 0 1442.2 0.0 5.4e-21 74.5 0.0 31.2 31 0 0 31 31 31 31 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK72603.1 - 1.1e-275 891.0 0.0 2.4e-11 44.1 0.1 31.5 31 0 0 31 31 31 31 Immunoglobulin domain Ig_2 PF13895.6 VDK72603.1 - 5.2e-154 500.9 0.0 3.4e-08 33.7 0.0 31.1 31 0 0 31 31 31 27 Immunoglobulin domain ig PF00047.25 VDK72603.1 - 1.2e-151 493.3 0.0 4.7e-09 36.3 0.0 28.7 30 0 0 30 30 30 22 Immunoglobulin domain V-set PF07686.17 VDK72603.1 - 1.1e-84 279.8 5.6 0.00096 19.3 0.0 35.5 30 9 0 30 30 30 17 Immunoglobulin V-set domain Titin_Ig-rpts PF06582.12 VDK72603.1 - 4.6e-67 221.5 83.6 2.9e-05 23.9 2.1 18.8 18 0 0 18 18 18 15 Titin repeat C1-set PF07654.15 VDK72603.1 - 1.8e-38 130.8 0.0 0.15 12.5 0.0 22.0 25 0 0 25 25 22 7 Immunoglobulin C1-set domain Ig_6 PF18452.1 VDK72603.1 - 9.1e-34 114.8 2.0 0.45 10.1 0.0 18.6 19 0 0 19 19 19 6 Immunoglobulin domain BiPBP_C PF06832.12 VDK72603.1 - 2.7e-33 113.8 0.0 3.7 7.7 0.0 25.1 28 1 0 28 28 27 3 Penicillin-Binding Protein C-terminus Family C2-set_2 PF08205.12 VDK72603.1 - 2.8e-20 72.2 1.3 0.5 10.5 0.0 19.0 23 0 0 23 23 23 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 VDK72603.1 - 1.5e-17 63.8 0.0 2.5 8.3 0.0 17.1 21 0 0 21 21 19 1 Natural killer cell receptor 2B4 Ig_4 PF16680.5 VDK72603.1 - 3.2e-17 62.6 3.8 6.2 7.2 0.0 14.5 16 0 0 16 16 15 2 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 VDK72603.1 - 1.9e-12 47.3 8.6 3.7 7.5 0.0 13.7 13 1 1 14 14 12 2 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 VDK72603.1 - 7e-11 42.0 7.8 5.3 7.2 0.0 12.7 14 0 0 14 14 13 1 Izumo-like Immunoglobulin domain Herpes_gE PF02480.16 VDK72603.1 - 9.9e-07 27.8 0.1 4.8 5.8 0.0 8.5 8 0 0 8 8 8 2 Alphaherpesvirus glycoprotein E C2-set PF05790.15 VDK72603.1 - 0.00071 19.7 14.3 0.67 10.2 0.1 11.2 16 0 0 16 16 16 1 Immunoglobulin C2-set domain PKD PF00801.20 VDK72603.1 - 0.039 13.8 0.8 19 5.2 0.2 5.5 7 0 0 7 7 6 0 PKD domain ACAS_N PF16177.5 VDK72603.1 - 1.1 9.2 8.9 86 3.2 0.0 6.7 9 0 0 9 9 7 0 Acetyl-coenzyme A synthetase N-terminus I-set PF07679.16 VDK72604.1 - 7.5e-116 378.5 13.3 1.2e-18 67.0 0.0 14.0 13 0 0 13 13 13 13 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK72604.1 - 4.5e-82 270.7 14.7 1.1e-10 41.9 0.0 15.1 14 0 0 14 14 14 13 Immunoglobulin domain ig PF00047.25 VDK72604.1 - 2e-40 136.8 4.3 3.4e-06 27.1 0.0 11.1 10 0 0 10 10 10 7 Immunoglobulin domain Ig_2 PF13895.6 VDK72604.1 - 2.3e-38 130.4 21.9 5.6e-05 23.4 0.0 12.4 14 0 0 14 14 14 8 Immunoglobulin domain V-set PF07686.17 VDK72604.1 - 2.3e-13 50.3 14.3 0.0079 16.4 0.0 10.3 8 5 0 8 8 8 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK72604.1 - 7.2e-08 32.4 0.1 7 6.8 0.0 7.6 7 0 0 7 7 7 2 CD80-like C2-set immunoglobulin domain Adeno_E3_CR1 PF02440.15 VDK72604.1 - 9.2e-05 22.2 6.1 0.039 13.7 0.4 4.0 3 0 0 3 3 3 2 Adenovirus E3 region protein CR1 Receptor_2B4 PF11465.8 VDK72604.1 - 0.075 13.2 0.2 2.8 8.2 0.0 3.5 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 SesA PF17107.5 VDK72604.1 - 0.09 13.0 14.8 1.3 9.3 0.4 3.1 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases C1-set PF07654.15 VDK72604.1 - 0.42 11.0 15.1 2.1 8.8 0.3 7.4 8 0 0 8 8 7 0 Immunoglobulin C1-set domain DUF3947 PF13135.6 VDK72604.1 - 9.2 6.5 7.9 96 3.3 4.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3947) I-set PF07679.16 VDK72606.1 - 2.3e-45 152.6 0.8 7.1e-17 61.3 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK72606.1 - 3.7e-36 123.6 1.8 8.2e-13 48.8 0.1 5.0 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 VDK72606.1 - 6.8e-22 77.6 3.5 8.3e-09 35.7 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.25 VDK72606.1 - 1.2e-15 57.5 10.1 2.1e-06 27.8 0.0 5.4 6 0 0 6 6 6 3 Immunoglobulin domain V-set PF07686.17 VDK72606.1 - 1.9e-07 31.2 2.8 0.0047 17.1 0.1 4.9 3 2 0 3 3 3 2 Immunoglobulin V-set domain Ig_5 PF16681.5 VDK72606.1 - 0.01 16.2 0.2 12 6.4 0.0 3.8 3 0 0 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain APG6_N PF17675.1 VDK72624.1 - 0.00093 19.7 14.8 0.00093 19.7 14.8 5.4 2 2 4 6 6 6 2 Apg6 coiled-coil region DUF948 PF06103.11 VDK72624.1 - 0.6 10.4 19.0 1.2 9.4 0.5 5.5 4 2 0 5 5 5 0 Bacterial protein of unknown function (DUF948) HRDC PF00570.23 VDK72624.1 - 0.81 9.7 5.8 0.49 10.4 0.4 3.3 3 0 0 3 3 3 0 HRDC domain VWA_2 PF13519.6 VDK72624.1 - 1.5 9.5 4.2 11 6.7 0.0 4.0 4 0 0 4 4 4 0 von Willebrand factor type A domain HSBP1 PF06825.12 VDK72624.1 - 1.6 8.7 12.0 1.9 8.4 4.1 3.9 2 0 0 2 2 2 0 Heat shock factor binding protein 1 LIM PF00412.22 VDK72628.1 - 4.1e-06 26.9 5.9 9.2e-06 25.8 5.9 1.6 1 0 0 1 1 1 1 LIM domain Transglut_core PF01841.19 VDK72628.1 - 0.024 15.1 0.0 0.054 13.9 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily Ly49 PF08391.10 VDK72628.1 - 0.97 9.8 3.4 2.1 8.7 3.4 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Pro_isomerase PF00160.21 VDK72629.1 - 8.5e-41 139.9 0.1 1.7e-40 138.9 0.1 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4604 PF15377.6 VDK72629.1 - 0.032 14.7 1.4 0.032 14.7 1.4 3.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4604) TIM PF00121.18 VDK72630.1 - 4e-92 308.0 0.1 4.6e-92 307.8 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase tRNA-synt_1e PF01406.19 VDK72632.1 - 2e-124 414.9 1.1 3.6e-124 414.0 1.1 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 VDK72632.1 - 3e-05 23.0 0.4 0.013 14.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1c PF00749.21 VDK72632.1 - 0.0087 15.0 0.0 0.0087 15.0 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1 PF00133.22 VDK72632.1 - 0.015 13.6 0.8 0.24 9.6 0.0 2.8 3 0 0 3 3 3 0 tRNA synthetases class I (I, L, M and V) DNA_pol3_a_NII PF11490.8 VDK72632.1 - 7.8 6.4 12.3 0.33 10.9 0.1 3.1 3 0 0 3 3 3 0 DNA polymerase III polC-type N-terminus II Motile_Sperm PF00635.26 VDK72633.1 - 8.5e-05 22.4 0.0 0.00012 21.9 0.0 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain PIN_4 PF13638.6 VDK72635.1 - 5.6e-23 81.7 0.5 8.2e-21 74.7 0.1 2.6 2 0 0 2 2 2 2 PIN domain WW PF00397.26 VDK72635.1 - 1.3e-10 41.2 1.8 2.2e-10 40.4 1.8 1.4 1 0 0 1 1 1 1 WW domain PIN_9 PF18477.1 VDK72635.1 - 0.049 13.9 0.1 0.52 10.6 0.1 2.6 1 1 0 1 1 1 0 PIN like domain DUF3500 PF12006.8 VDK72635.1 - 0.15 11.5 0.3 0.26 10.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) Dor1 PF04124.12 VDK72637.1 - 3.4e-68 229.8 3.0 1.1e-67 228.2 3.1 1.7 2 0 0 2 2 2 1 Dor1-like family Laminin_II PF06009.12 VDK72637.1 - 0.017 15.2 0.1 0.046 13.7 0.1 1.8 1 0 0 1 1 1 0 Laminin Domain II Laminin_I PF06008.14 VDK72637.1 - 0.02 14.6 0.7 0.037 13.7 0.7 1.4 1 0 0 1 1 1 0 Laminin Domain I EIAV_Rev PF11129.8 VDK72637.1 - 0.12 12.6 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 Rev protein of equine infectious anaemia virus CENP-H PF05837.12 VDK72637.1 - 3.5 8.1 6.1 4.4 7.8 0.4 2.9 2 1 1 3 3 3 0 Centromere protein H (CENP-H) BACK PF07707.15 VDK72638.1 - 7.1e-11 42.1 0.2 5.8e-10 39.2 0.0 2.1 1 1 1 2 2 2 1 BTB And C-terminal Kelch Macoilin PF09726.9 VDK72638.1 - 4.2 5.8 16.3 5.8 5.4 16.3 1.2 1 0 0 1 1 1 0 Macoilin family eIF3_N PF09440.10 VDK72639.1 - 6.3e-35 120.5 0.9 6.3e-35 120.5 0.9 2.1 2 0 0 2 2 2 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 VDK72639.1 - 4.8e-18 65.6 2.9 5.6e-18 65.4 0.1 2.6 3 0 0 3 3 3 1 PCI domain SHNi-TPR PF10516.9 VDK72639.1 - 0.024 14.1 0.9 0.51 9.8 0.0 3.2 4 0 0 4 4 4 0 SHNi-TPR CSN8_PSD8_EIF3K PF10075.9 VDK72639.1 - 0.029 14.3 0.1 0.094 12.7 0.1 1.8 1 1 0 1 1 1 0 CSN8/PSMD8/EIF3K family Takusan PF04822.13 VDK72639.1 - 0.2 11.5 3.2 0.63 10.0 0.2 2.9 2 0 0 2 2 2 0 Takusan GST_N_3 PF13417.6 VDK72640.1 - 0.00072 19.9 0.0 0.002 18.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DHC PF09626.10 VDK72643.1 - 0.15 13.0 0.7 0.33 11.8 0.7 1.5 1 0 0 1 1 1 0 Dihaem cytochrome c S4 PF01479.25 VDK72648.1 - 7e-10 38.5 1.7 2.8e-09 36.5 1.7 2.1 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 VDK72648.1 - 2.7e-05 25.0 0.4 5e-05 24.1 0.2 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain WD40 PF00400.32 VDK72649.1 - 4.8e-27 93.7 19.5 2e-05 25.3 0.2 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK72649.1 - 5.8e-06 26.5 2.1 5 7.5 0.1 4.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 VDK72649.1 - 0.00021 20.0 0.9 0.00098 17.7 0.3 2.0 1 1 1 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.5 VDK72649.1 - 0.00024 20.6 0.6 0.16 11.3 0.0 3.0 3 0 0 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 VDK72649.1 - 0.038 12.7 0.2 0.58 8.8 0.0 2.9 1 1 1 2 2 2 0 Nup133 N terminal like C2 PF00168.30 VDK72653.1 - 1e-11 45.1 0.0 1.7e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain RBD-FIP PF09457.10 VDK72653.1 - 7e-09 35.5 1.0 1.1e-08 34.8 1.0 1.3 1 0 0 1 1 1 1 FIP domain Zap1_zf2 PF18217.1 VDK72653.1 - 1.2 9.2 3.0 0.75 9.8 0.8 1.9 2 0 0 2 2 2 0 Zap1 zinc finger 2 Nucleopor_Nup85 PF07575.13 VDK72654.1 - 2.5e-109 366.4 1.9 3.1e-109 366.1 1.9 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin Actin PF00022.19 VDK72655.1 - 4.7e-08 32.1 0.0 5.2e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Actin NADH_B2 PF14813.6 VDK72669.1 - 2.1e-16 59.5 0.1 2.1e-16 59.5 0.1 1.6 2 0 0 2 2 2 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Synaptobrevin PF00957.21 VDK72671.1 - 0.49 10.2 3.7 0.38 10.6 0.2 2.0 1 1 1 2 2 2 0 Synaptobrevin RTC PF01137.21 VDK72672.1 - 7.9e-48 162.6 0.0 9.1e-48 162.4 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 VDK72672.1 - 5.6e-29 100.7 0.0 1.2e-28 99.7 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain WD-3 PF09765.9 VDK72674.1 - 0.003 16.9 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 2 WD-repeat region Pro_3_hydrox_C PF05373.11 VDK72674.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal RNase_H2_suC PF08615.11 VDK72677.1 - 2e-13 50.7 0.1 3.3e-12 46.8 0.0 2.0 1 1 1 2 2 2 2 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF3748 PF12566.8 VDK72677.1 - 0.016 15.1 0.0 0.5 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3748) Torsin PF06309.11 VDK72678.1 - 4.1e-47 159.4 0.3 6.9e-47 158.7 0.3 1.4 1 0 0 1 1 1 1 Torsin AAA_2 PF07724.14 VDK72678.1 - 0.00023 21.3 0.0 0.00056 20.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 VDK72678.1 - 0.004 17.2 0.0 0.0073 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 VDK72678.1 - 0.0072 16.8 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) R-HINP1I PF11463.8 VDK72678.1 - 0.036 13.5 0.5 0.062 12.7 0.5 1.3 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease NB-ARC PF00931.22 VDK72678.1 - 0.059 12.5 0.1 0.11 11.6 0.1 1.5 1 1 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 VDK72678.1 - 0.066 13.2 0.0 0.22 11.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 VDK72678.1 - 0.085 13.1 0.0 3.3 8.0 0.0 2.4 1 1 0 1 1 1 0 AAA domain Tuberin PF03542.16 VDK72679.1 - 4.1e-36 124.8 0.4 9.4e-29 100.6 0.1 2.4 2 0 0 2 2 2 2 Tuberin DUF3384 PF11864.8 VDK72679.1 - 5.8e-34 117.8 9.7 4.8e-32 111.5 6.4 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 VDK72679.1 - 2.2e-27 95.8 0.0 6.2e-27 94.4 0.0 1.8 2 0 0 2 2 2 1 Rap/ran-GAP HEAT PF02985.22 VDK72680.1 - 5.7e-08 32.4 7.0 0.0048 17.0 0.1 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 VDK72680.1 - 5.1e-05 23.6 0.3 0.0038 17.6 0.0 3.6 3 0 0 3 3 3 1 HEAT repeats CLASP_N PF12348.8 VDK72680.1 - 0.014 15.0 0.2 0.3 10.6 0.1 2.5 2 0 0 2 2 2 0 CLASP N terminal HEAT_EZ PF13513.6 VDK72680.1 - 0.11 13.0 5.7 5.2 7.7 0.1 4.2 4 0 0 4 4 4 0 HEAT-like repeat SURF4 PF02077.15 VDK72680.1 - 0.12 12.0 0.1 0.23 11.0 0.1 1.4 1 0 0 1 1 1 0 SURF4 family Arm PF00514.23 VDK72680.1 - 0.15 12.2 2.7 38 4.5 0.0 3.8 2 1 1 3 3 3 0 Armadillo/beta-catenin-like repeat Motile_Sperm PF00635.26 VDK72682.1 - 2.4e-07 30.6 0.0 4e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain TB2_DP1_HVA22 PF03134.19 VDK72682.1 - 0.0042 17.0 1.5 0.0093 15.9 1.5 1.6 1 0 0 1 1 1 1 TB2/DP1, HVA22 family WBS_methylT PF12589.8 VDK72682.1 - 0.066 14.0 1.1 0.16 12.7 1.1 1.6 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome PRA1 PF03208.19 VDK72682.1 - 0.49 10.0 6.0 0.82 9.3 6.0 1.3 1 0 0 1 1 1 0 PRA1 family protein ISG65-75 PF11727.8 VDK72683.1 - 0.002 17.4 3.3 0.0025 17.1 3.3 1.1 1 0 0 1 1 1 1 Invariant surface glycoprotein DUF1444 PF07285.11 VDK72683.1 - 0.019 14.5 0.5 0.025 14.2 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1444) DUF4628 PF15429.6 VDK72683.1 - 0.03 14.0 0.1 0.034 13.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) DUF4570 PF15134.6 VDK72683.1 - 0.041 13.9 0.5 0.051 13.6 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) DUF4152 PF13680.6 VDK72683.1 - 0.11 11.9 0.1 0.12 11.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4152) DUF573 PF04504.14 VDK72683.1 - 0.11 13.1 2.4 0.25 12.0 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF573 Cys_rich_FGFR PF00839.17 VDK72684.1 - 7.7e-146 474.4 92.4 9.8e-16 57.7 1.7 16.2 16 0 0 16 16 16 16 Cysteine rich repeat ESCRT-II PF05871.12 VDK72684.1 - 0.17 12.2 0.2 1.2 9.4 0.1 2.3 2 0 0 2 2 2 0 ESCRT-II complex subunit DUF3849 PF12960.7 VDK72684.1 - 0.5 10.4 2.9 19 5.3 0.2 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3849) zf-LITAF-like PF10601.9 VDK72684.1 - 0.6 10.4 6.1 0.32 11.3 0.4 3.5 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain bZIP_Maf PF03131.17 VDK72685.1 - 0.0022 18.4 0.9 0.0079 16.7 0.9 2.0 1 0 0 1 1 1 1 bZIP Maf transcription factor SEA PF01390.20 VDK72685.1 - 0.053 13.6 0.2 0.23 11.6 0.2 2.2 2 0 0 2 2 2 0 SEA domain NifT PF06988.11 VDK72685.1 - 0.14 12.0 0.1 0.37 10.6 0.1 1.7 1 0 0 1 1 1 0 NifT/FixU protein Exonuc_VII_L PF02601.15 VDK72685.1 - 8.2 5.9 12.6 1.9 8.0 7.0 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit GN3L_Grn1 PF08701.11 VDK72686.1 - 7.3e-18 64.4 22.0 7.3e-18 64.4 22.0 3.5 4 0 0 4 4 4 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 VDK72686.1 - 9.5e-18 64.3 0.5 7.1e-15 55.1 0.0 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK72686.1 - 1.2e-10 41.1 0.1 2.1e-06 27.3 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 VDK72686.1 - 9.8e-06 25.6 0.1 0.0048 16.8 0.1 2.6 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 VDK72686.1 - 2.2e-05 24.1 0.0 0.00058 19.4 0.0 3.0 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 VDK72686.1 - 0.00068 19.7 8.7 0.0013 18.8 0.0 3.3 3 2 0 3 3 3 1 Dynamin family cobW PF02492.19 VDK72686.1 - 0.0056 16.3 0.1 0.27 10.8 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 VDK72686.1 - 0.085 13.4 0.7 0.61 10.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 VDK72686.1 - 0.17 10.8 0.6 0.49 9.3 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB E1_DerP2_DerF2 PF02221.15 VDK72687.1 - 5.8e-17 62.4 0.3 7.6e-17 62.0 0.3 1.1 1 0 0 1 1 1 1 ML domain SHR-BD PF06650.12 VDK72688.1 - 1.3e-58 198.6 7.3 8.9e-56 189.2 0.2 3.1 3 0 0 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13 PF16908.5 VDK72688.1 - 1e-38 133.5 14.4 6e-23 81.9 0.2 3.6 3 1 1 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 VDK72688.1 - 1.1e-31 109.4 2.9 1.1e-31 109.4 2.9 2.2 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 VDK72688.1 - 5e-12 46.0 6.8 2.2e-10 40.6 1.5 3.7 2 1 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal GST_N_4 PF17172.4 VDK72690.1 - 1.3e-12 48.4 0.0 1.9e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N_3 PF13417.6 VDK72690.1 - 0.0091 16.4 0.0 0.069 13.6 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DCX PF03607.17 VDK72718.1 - 1.4e-22 79.5 0.0 1.9e-15 56.7 0.0 2.4 2 0 0 2 2 2 2 Doublecortin PLAT PF01477.23 VDK72718.1 - 8.4e-06 26.3 0.4 1.8e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 PLAT/LH2 domain DUF4786 PF16027.5 VDK72718.1 - 0.16 12.5 0.1 0.16 12.5 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4786) PLAT PF01477.23 VDK72719.1 - 4.9e-21 75.5 1.8 8.3e-07 29.6 0.5 4.5 4 0 0 4 4 4 4 PLAT/LH2 domain DUF2371 PF10177.9 VDK72720.1 - 1.1e-06 28.9 0.0 1.8e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2371) FKBP_C PF00254.28 VDK72721.1 - 3.4e-14 52.9 0.0 7.1e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 PF00036.32 VDK72721.1 - 2.2e-10 39.3 6.5 6.4e-06 25.4 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 VDK72721.1 - 1.3e-08 34.1 4.2 0.00025 20.7 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 VDK72721.1 - 2e-07 31.4 4.6 3.7e-06 27.3 1.5 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 VDK72721.1 - 3.5e-07 30.0 2.7 0.0019 18.0 0.2 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK72721.1 - 1.9e-06 27.1 6.8 0.00048 19.5 0.0 3.4 3 0 0 3 3 3 2 EF hand DUF3872 PF12988.7 VDK72721.1 - 0.00098 18.9 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function, B. Theta Gene description (DUF3872) SPARC_Ca_bdg PF10591.9 VDK72721.1 - 0.0051 17.1 0.8 0.55 10.6 0.6 2.8 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 VDK72721.1 - 0.022 15.0 0.1 2.7 8.3 0.0 3.0 3 0 0 3 3 3 0 Dockerin type I domain MFS_1 PF07690.16 VDK72723.1 - 1.1e-16 60.8 49.5 3.3e-12 46.0 20.5 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily ATG22 PF11700.8 VDK72723.1 - 5.5e-05 22.0 15.8 7.5e-05 21.5 15.8 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like OATP PF03137.20 VDK72723.1 - 0.0011 17.3 10.3 0.0011 17.3 10.3 2.2 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF92 PF01940.16 VDK72723.1 - 0.28 10.6 9.3 0.45 9.9 0.3 2.6 2 0 0 2 2 2 0 Integral membrane protein DUF92 zf-H2C2_2 PF13465.6 VDK72724.1 - 8.1e-15 54.5 16.2 1.4e-07 31.6 0.4 3.6 4 0 0 4 4 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 VDK72724.1 - 2.6e-11 43.3 19.0 9.2e-05 22.7 0.8 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK72724.1 - 3.7e-07 30.4 26.2 0.001 19.7 0.8 3.9 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK72724.1 - 0.0016 18.6 5.7 2 8.8 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK72724.1 - 0.03 14.7 10.2 0.48 10.9 0.8 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 VDK72724.1 - 0.038 14.0 0.1 0.038 14.0 0.1 3.6 4 0 0 4 4 3 0 C2H2-type zinc finger Mcl1_mid PF12341.8 VDK72724.1 - 0.041 13.2 0.5 0.058 12.7 0.5 1.1 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region FYVE PF01363.21 VDK72724.1 - 0.18 12.0 8.5 4.1 7.6 8.6 2.4 1 1 0 1 1 1 0 FYVE zinc finger PyrI_C PF02748.15 VDK72724.1 - 0.25 11.3 3.9 6 6.9 0.1 2.9 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn-ribbon_8 PF09723.10 VDK72724.1 - 0.49 10.6 11.8 4.5 7.5 0.2 3.2 2 1 1 3 3 3 0 Zinc ribbon domain HypA PF01155.19 VDK72724.1 - 0.55 10.3 4.3 1.2 9.1 0.3 2.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-CHCC PF10276.9 VDK72724.1 - 0.58 10.2 5.5 21 5.3 0.1 3.3 3 0 0 3 3 3 0 Zinc-finger domain zf-C2H2_11 PF16622.5 VDK72724.1 - 2.2 8.1 14.0 0.18 11.6 1.9 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-TRAF PF02176.18 VDK72724.1 - 3.1 8.6 12.5 0.2 12.4 5.4 2.3 2 1 1 3 3 2 0 TRAF-type zinc finger zf-C2H2_2 PF12756.7 VDK72724.1 - 4.1 7.8 11.6 2.9 8.3 0.4 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.9 VDK72724.1 - 4.2 7.6 9.1 13 6.0 0.1 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-AN1 PF01428.16 VDK72724.1 - 4.9 7.4 16.6 13 6.1 1.1 3.4 2 1 1 3 3 3 0 AN1-like Zinc finger C5HCH PF17982.1 VDK72724.1 - 9.1 6.5 12.7 20 5.4 1.2 3.5 2 1 1 3 3 3 0 NSD Cys-His rich domain mTERF PF02536.14 VDK72726.1 - 7.4e-10 38.3 3.7 6.1e-06 25.4 0.2 2.2 1 1 1 2 2 2 2 mTERF Adap_comp_sub PF00928.21 VDK72729.1 - 6.5e-91 304.4 0.4 7.9e-91 304.1 0.4 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 VDK72729.1 - 6.2e-10 39.2 0.5 1.2e-09 38.3 0.5 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HemX PF04375.14 VDK72731.1 - 0.0069 15.7 6.4 0.011 15.1 6.4 1.2 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Shisa PF13908.6 VDK72731.1 - 0.016 15.5 1.7 0.024 14.9 1.7 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ETRAMP PF09716.10 VDK72731.1 - 0.017 15.2 1.7 0.054 13.6 1.7 2.2 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) CD34_antigen PF06365.12 VDK72731.1 - 0.03 13.9 5.4 0.042 13.4 4.2 1.8 1 1 0 1 1 1 0 CD34/Podocalyxin family Tubulin_2 PF13809.6 VDK72731.1 - 0.074 12.2 3.4 0.17 11.0 3.4 1.6 1 1 0 1 1 1 0 Tubulin like CLN3 PF02487.17 VDK72731.1 - 0.12 11.3 2.3 0.18 10.8 2.3 1.2 1 0 0 1 1 1 0 CLN3 protein MAS20 PF02064.15 VDK72731.1 - 0.25 11.4 6.9 0.44 10.6 5.9 1.8 2 0 0 2 2 2 0 MAS20 protein import receptor Mit_KHE1 PF10173.9 VDK72731.1 - 0.26 11.3 11.8 1.2 9.1 8.2 2.2 1 1 0 2 2 2 0 Mitochondrial K+-H+ exchange-related DUF4834 PF16118.5 VDK72731.1 - 0.27 12.2 14.5 0.057 14.4 6.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) DUF4407 PF14362.6 VDK72731.1 - 0.51 9.7 3.3 0.74 9.1 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EphA2_TM PF14575.6 VDK72731.1 - 0.59 11.0 2.8 2.7 8.9 2.8 2.2 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Hydrolase_3 PF08282.12 VDK72731.1 - 0.6 9.8 4.7 0.9 9.2 4.7 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Connexin PF00029.19 VDK72731.1 - 0.9 9.3 6.2 1.9 8.2 6.0 1.7 2 1 0 2 2 2 0 Connexin DUF2681 PF10883.8 VDK72731.1 - 5.7 7.4 11.4 0.17 12.3 2.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2681) HPHLAWLY PF14925.6 VDK72733.1 - 0.01 14.5 0.0 0.012 14.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function Umbravirus_LDM PF04817.12 VDK72733.1 - 0.14 11.4 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Umbravirus long distance movement (LDM) family DUF4457 PF14652.6 VDK72735.1 - 8.8e-74 248.7 1.0 5.5e-44 150.8 0.1 5.8 2 1 3 5 5 5 3 Domain of unknown function (DUF4457) CSRNP_N PF16019.5 VDK72735.1 - 9.3e-45 153.2 21.6 9.3e-44 149.9 21.6 2.1 1 1 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus Cu2_monoox_C PF03712.15 VDK72736.1 - 9.5e-38 129.2 0.0 1.7e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 VDK72736.1 - 1.3e-24 86.9 0.1 2.5e-24 86.0 0.1 1.5 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain Piwi PF02171.17 VDK72737.1 - 3.4e-88 295.8 0.0 9e-88 294.4 0.0 1.7 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.22 VDK72737.1 - 2.1e-11 43.8 0.4 4.9e-11 42.6 0.2 1.7 2 0 0 2 2 2 1 PAZ domain ArgoL1 PF08699.10 VDK72737.1 - 9e-10 38.1 0.0 2.4e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 VDK72737.1 - 7.8e-09 36.3 0.1 2.5e-08 34.6 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of argonaute ArgoL2 PF16488.5 VDK72737.1 - 0.018 15.3 0.0 0.057 13.8 0.0 1.9 1 1 0 1 1 1 0 Argonaute linker 2 domain MFP2b PF12150.8 VDK72738.1 - 4.2e-150 499.8 0.1 4.7e-150 499.6 0.1 1.0 1 0 0 1 1 1 1 Cytosolic motility protein Neur_chan_LBD PF02931.23 VDK72739.1 - 3.5e-64 216.2 3.3 5e-64 215.7 3.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK72739.1 - 3.5e-62 210.6 0.4 4.7e-62 210.2 0.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2207 PF09972.9 VDK72739.1 - 0.034 12.9 0.9 0.19 10.5 0.6 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Spo7 PF03907.13 VDK72739.1 - 4.6 6.7 6.8 0.62 9.5 1.0 2.1 2 0 0 2 2 2 0 Spo7-like protein Hormone_recep PF00104.30 VDK72760.1 - 2.3e-14 53.4 1.2 5.1e-13 49.1 1.2 2.2 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 VDK72760.1 - 0.0019 18.6 2.6 0.0044 17.4 2.6 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Forkhead PF00250.18 VDK72761.1 - 9.1e-37 125.2 1.3 2.3e-36 123.9 1.3 1.7 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 VDK72761.1 - 5.9e-06 26.5 1.4 1e-05 25.8 0.4 2.0 2 0 0 2 2 2 1 FHA domain Sm_multidrug_ex PF06695.11 VDK72763.1 - 0.059 14.0 2.9 3.2 8.4 0.8 2.5 1 1 1 2 2 2 0 Putative small multi-drug export protein RepA1_leader PF08048.12 VDK72763.1 - 0.081 13.2 0.1 0.081 13.2 0.1 2.0 2 0 0 2 2 2 0 Tap RepA1 leader peptide RNase_T PF00929.24 VDK72764.1 - 4.9e-24 85.7 0.0 9.3e-24 84.8 0.0 1.5 1 0 0 1 1 1 1 Exonuclease Dimer_Tnp_hAT PF05699.14 VDK72764.1 - 0.00086 19.1 0.1 0.004 16.9 0.1 2.1 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region MMS22L_N PF14910.6 VDK72766.1 - 7.5e-05 21.4 0.3 0.00014 20.5 0.3 1.4 1 0 0 1 1 1 1 S-phase genomic integrity recombination mediator, N-terminal Innexin PF00876.18 VDK72767.1 - 2.3e-97 326.5 11.8 2.9e-97 326.1 11.8 1.1 1 0 0 1 1 1 1 Innexin Ion_trans PF00520.31 VDK72768.1 - 1.7e-204 675.9 53.5 6.7e-55 186.0 5.2 6.1 4 2 2 6 6 6 6 Ion transport protein PKD_channel PF08016.12 VDK72768.1 - 1.2e-13 50.5 58.6 1.1e-07 30.9 0.1 8.6 8 2 1 9 9 9 7 Polycystin cation channel DPM3 PF08285.11 VDK72768.1 - 2.7e-05 24.3 1.5 0.41 10.9 0.2 4.3 3 0 0 3 3 3 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) FAM176 PF14851.6 VDK72768.1 - 0.00038 20.1 0.4 2.1 8.0 0.1 4.2 4 0 0 4 4 4 1 FAM176 family DUF4834 PF16118.5 VDK72768.1 - 0.0018 19.2 14.2 2.3 9.2 0.0 6.1 6 0 0 6 6 6 2 Domain of unknown function (DUF4834) DUF2938 PF11158.8 VDK72768.1 - 0.11 12.0 0.2 18 4.8 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2938) Ctr PF04145.15 VDK72768.1 - 5.3 7.7 17.1 6.3 7.4 0.2 5.8 5 3 0 5 5 5 0 Ctr copper transporter family Peptidase_S49_N PF08496.10 VDK72768.1 - 6.2 6.9 8.4 4.2 7.4 1.6 3.3 3 0 0 3 3 3 0 Peptidase family S49 N-terminal Ion_trans PF00520.31 VDK72769.1 - 4.7e-222 733.4 56.4 2.2e-63 213.8 12.3 5.1 4 1 1 5 5 5 5 Ion transport protein PKD_channel PF08016.12 VDK72769.1 - 1.3e-12 47.1 68.4 1.1e-07 30.9 0.1 9.5 8 3 2 10 10 10 8 Polycystin cation channel DPM3 PF08285.11 VDK72769.1 - 2.8e-05 24.2 1.5 0.42 10.8 0.2 4.3 3 0 0 3 3 3 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) FAM176 PF14851.6 VDK72769.1 - 0.00041 20.0 0.4 2.1 8.0 0.1 4.2 4 0 0 4 4 4 1 FAM176 family DUF4834 PF16118.5 VDK72769.1 - 0.0015 19.4 14.2 2.3 9.2 0.0 6.3 6 0 0 6 6 6 2 Domain of unknown function (DUF4834) DUF2938 PF11158.8 VDK72769.1 - 0.1 12.1 0.2 19 4.7 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2938) Ctr PF04145.15 VDK72769.1 - 0.74 10.4 14.1 5.1 7.7 0.1 5.8 5 2 0 5 5 5 0 Ctr copper transporter family Peptidase_S49_N PF08496.10 VDK72769.1 - 6.6 6.8 8.4 4.3 7.4 1.6 3.3 3 0 0 3 3 3 0 Peptidase family S49 N-terminal TUDOR PF00567.24 VDK72813.1 - 0.014 15.4 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Tudor domain Peptidase_S24 PF00717.23 VDK72814.1 - 7.1e-09 35.5 0.0 1.2e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 VDK72814.1 - 0.0015 18.3 0.0 0.014 15.2 0.0 2.1 1 1 0 2 2 2 1 Signal peptidase, peptidase S26 Sec7 PF01369.20 VDK72815.1 - 3.4e-62 209.4 0.0 7.5e-62 208.3 0.0 1.6 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 VDK72815.1 - 3.8e-27 95.1 3.6 3.8e-27 95.1 3.6 3.2 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 VDK72815.1 - 0.0056 16.5 0.0 0.48 10.3 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) Y_phosphatase PF00102.27 VDK72816.1 - 2.7e-26 92.6 1.4 2.8e-26 92.5 0.1 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK72816.1 - 0.0058 16.5 0.7 0.045 13.6 0.7 2.2 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain F_bP_aldolase PF01116.20 VDK72816.1 - 0.037 13.5 0.1 0.062 12.8 0.1 1.3 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II Toxin_TOLIP PF00087.21 VDK72820.1 - 0.12 12.6 15.2 0.24 11.7 15.2 1.5 1 0 0 1 1 1 0 Snake toxin and toxin-like protein MFS_1 PF07690.16 VDK72823.1 - 2.9e-41 141.6 29.7 5.4e-41 140.7 29.1 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily AAA_PrkA PF08298.11 VDK72823.1 - 0.022 13.7 0.0 0.032 13.1 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain HflK_N PF12221.8 VDK72823.1 - 0.026 14.5 1.3 0.33 11.0 0.3 2.4 2 0 0 2 2 2 0 Bacterial membrane protein N terminal Sugar_tr PF00083.24 VDK72823.1 - 0.11 11.3 14.1 0.23 10.3 14.1 1.5 1 1 0 1 1 1 0 Sugar (and other) transporter LRR_8 PF13855.6 VDK72824.1 - 3.9e-64 212.3 71.2 9.3e-17 60.5 7.5 6.9 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 VDK72824.1 - 1.5e-36 123.8 54.7 9e-08 32.3 0.1 8.7 5 2 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK72824.1 - 3.4e-29 101.4 2.7 1.1e-08 35.1 0.2 3.3 1 1 3 4 4 4 4 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 VDK72824.1 - 1.2e-21 73.9 50.7 0.12 13.0 0.1 13.3 11 2 1 12 12 12 10 Leucine Rich Repeat LRR_9 PF14580.6 VDK72824.1 - 5.5e-11 42.3 18.3 3.1e-05 23.5 1.3 4.6 1 1 4 5 5 5 5 Leucine-rich repeat LRR_6 PF13516.6 VDK72824.1 - 3.8e-07 29.6 61.0 0.65 10.2 0.8 12.9 12 1 0 13 13 13 8 Leucine Rich repeat RACo_linker PF17650.1 VDK72824.1 - 0.073 12.9 0.0 0.23 11.3 0.0 1.8 2 0 0 2 2 2 0 RACo linker region Mpp10 PF04006.12 VDK72828.1 - 2.3e-100 336.8 28.9 2.3e-100 336.8 28.9 2.2 2 0 0 2 2 2 1 Mpp10 protein DUF3545 PF12065.8 VDK72828.1 - 0.088 12.8 6.5 0.41 10.7 6.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) ALG11_N PF15924.5 VDK72831.1 - 1.8e-60 204.6 1.9 1e-58 198.8 0.1 3.1 2 1 2 4 4 4 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 VDK72831.1 - 8.9e-20 70.9 0.0 1.6e-19 70.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 VDK72831.1 - 7.2e-07 29.7 0.0 1.9e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Synaptobrevin PF00957.21 VDK72834.1 - 6.2e-13 48.3 0.3 1.3e-12 47.4 0.3 1.6 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 VDK72834.1 - 6.6e-12 45.3 0.0 1.3e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain NMT PF01233.19 VDK72835.1 - 5e-39 133.7 0.0 6.6e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain PDZ PF00595.24 VDK72863.1 - 1.5e-60 201.5 7.0 4.2e-17 62.3 0.1 4.4 4 0 0 4 4 4 4 PDZ domain LRR_8 PF13855.6 VDK72863.1 - 4.6e-38 128.8 39.5 2e-09 37.1 0.3 6.8 2 1 5 8 8 8 8 Leucine rich repeat PDZ_6 PF17820.1 VDK72863.1 - 2.6e-34 116.8 3.9 1.6e-09 37.4 0.2 4.6 4 0 0 4 4 4 4 PDZ domain LRR_4 PF12799.7 VDK72863.1 - 1e-28 98.9 49.0 9.4e-06 25.9 3.6 9.0 2 2 6 10 10 10 10 Leucine Rich repeats (2 copies) PDZ_2 PF13180.6 VDK72863.1 - 2.8e-25 88.4 2.2 4.7e-05 23.6 0.1 4.7 4 0 0 4 4 4 4 PDZ domain LRR_1 PF00560.33 VDK72863.1 - 8.4e-06 25.6 43.6 0.73 10.6 0.1 13.1 11 3 1 12 12 12 3 Leucine Rich Repeat GRASP55_65 PF04495.14 VDK72863.1 - 0.06 13.7 0.0 0.25 11.6 0.0 2.0 2 0 0 2 2 2 0 GRASP55/65 PDZ-like domain LRR_6 PF13516.6 VDK72863.1 - 0.097 12.8 41.2 1.4 9.1 0.2 9.9 10 0 0 10 10 10 0 Leucine Rich repeat Saw1 PF11561.8 VDK72863.1 - 0.1 12.1 0.6 0.21 11.1 0.6 1.5 1 0 0 1 1 1 0 Single strand annealing-weakened 1 C12orf66_like PF09404.10 VDK72864.1 - 2.1e-28 99.3 1.6 2.8e-28 99.0 1.6 1.1 1 0 0 1 1 1 1 KICSTOR complex C12orf66 like MBOAT PF03062.19 VDK72865.1 - 3e-09 36.7 5.7 3e-09 36.7 5.7 1.9 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Mal_decarbox_Al PF16957.5 VDK72865.1 - 0.12 10.7 0.0 0.16 10.2 0.0 1.2 1 0 0 1 1 1 0 Malonate decarboxylase, alpha subunit, transporter ELP6 PF09807.9 VDK72866.1 - 6e-07 29.1 0.1 4.5e-06 26.3 0.1 2.0 1 1 0 1 1 1 1 Elongation complex protein 6 Tk-SP_N-pro PF18237.1 VDK72866.1 - 0.048 13.7 1.5 0.76 9.9 0.1 2.4 2 0 0 2 2 2 0 Tk-SP N-propeptide domain Ribosomal_L13 PF00572.18 VDK72867.1 - 5.6e-10 39.6 0.1 3.8e-07 30.4 0.0 3.1 2 1 0 2 2 2 1 Ribosomal protein L13 Gemini_AL1 PF00799.20 VDK72867.1 - 0.12 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain DGCR6 PF07324.11 VDK72868.1 - 1.5e-15 57.3 0.1 1.7e-15 57.2 0.1 1.0 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DGCR6 PF07324.11 VDK72870.1 - 1e-05 25.3 0.0 1.1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein Med4 PF10018.9 VDK72871.1 - 0.0084 15.8 0.2 0.01 15.5 0.2 1.3 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 zf-C2H2_4 PF13894.6 VDK72872.1 - 1.3e-08 35.0 32.2 0.0095 16.7 1.0 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK72872.1 - 2.9e-06 27.4 35.0 0.00048 20.4 1.8 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK72872.1 - 3.9e-06 27.0 28.4 0.0007 19.9 1.1 5.4 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 VDK72872.1 - 9.9e-06 25.4 30.5 0.053 13.5 0.8 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 VDK72872.1 - 0.0018 18.9 3.0 0.0079 16.9 0.1 2.9 2 1 1 3 3 3 1 Zinc finger C2H2-type, 3 repeats CpXC PF14353.6 VDK72872.1 - 0.0022 18.0 8.4 12 6.0 0.0 4.2 3 1 1 4 4 4 1 CpXC protein zf-C2H2_jaz PF12171.8 VDK72872.1 - 0.034 14.4 0.2 0.034 14.4 0.2 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 VDK72872.1 - 0.071 13.1 3.9 6 7.0 0.3 2.7 2 0 0 2 2 2 0 BED zinc finger zf-C2HE PF16278.5 VDK72872.1 - 0.1 13.1 7.0 24 5.5 0.0 3.1 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger C1_1 PF00130.22 VDK72872.1 - 0.22 11.4 10.5 2.6 8.0 6.2 3.2 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf_UBZ PF18439.1 VDK72872.1 - 1.1 8.9 7.8 4 7.1 1.3 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-AN1 PF01428.16 VDK72872.1 - 1.4 9.2 17.7 11 6.3 0.2 4.3 3 1 1 4 4 4 0 AN1-like Zinc finger zf-C2H2_8 PF15909.5 VDK72872.1 - 2.2 8.7 10.9 2.1 8.7 6.2 2.7 2 1 1 3 3 3 0 C2H2-type zinc ribbon PHD PF00628.29 VDK72872.1 - 4 7.4 13.0 3.2 7.7 6.0 3.2 3 1 0 3 3 3 0 PHD-finger Cnd1 PF12717.7 VDK72873.1 - 7e-47 159.5 9.2 6.2e-43 146.6 1.0 3.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 VDK72873.1 - 1.8e-10 40.9 1.7 4.5e-10 39.6 0.3 2.4 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 VDK72873.1 - 2.2e-07 30.5 1.4 1.8 9.0 0.0 6.4 6 0 0 6 6 6 2 HEAT repeat Adaptin_N PF01602.20 VDK72873.1 - 1e-06 27.6 4.3 6.2e-05 21.7 0.3 3.4 2 2 2 4 4 4 2 Adaptin N terminal region Cnd3 PF12719.7 VDK72873.1 - 1.1e-05 24.8 8.1 3.5e-05 23.2 6.0 2.8 3 1 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 VDK72873.1 - 0.0006 20.2 0.8 0.3 11.5 0.0 5.0 6 0 0 6 6 6 1 HEAT repeats HEAT_EZ PF13513.6 VDK72873.1 - 0.0063 17.0 0.0 5.7 7.6 0.0 4.7 5 0 0 5 5 5 1 HEAT-like repeat YozD PF14162.6 VDK72873.1 - 0.056 13.7 0.0 0.41 11.0 0.0 2.6 1 0 0 1 1 1 0 YozD-like protein HalX PF08663.10 VDK72873.1 - 0.96 9.8 4.0 1.1 9.6 1.0 2.7 3 0 0 3 3 3 0 HalX domain Asparaginase_2 PF01112.18 VDK72874.1 - 7.8e-35 120.4 0.2 1.2e-34 119.7 0.2 1.3 1 0 0 1 1 1 1 Asparaginase Sushi PF00084.20 VDK72875.1 - 9e-81 266.4 59.6 3.6e-11 43.5 0.6 13.4 12 1 1 13 13 13 13 Sushi repeat (SCR repeat) WAP PF00095.21 VDK72875.1 - 0.00037 20.8 15.2 0.0048 17.2 15.2 3.2 1 0 0 1 1 1 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' ig PF00047.25 VDK72875.1 - 0.075 13.2 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain IMPDH PF00478.25 VDK72876.1 - 1.8e-74 250.9 0.0 3.8e-66 223.5 0.0 2.0 1 1 1 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 VDK72876.1 - 1.5e-05 24.2 1.7 2.5e-05 23.5 0.7 1.9 2 0 0 2 2 2 1 FMN-dependent dehydrogenase dCache_3 PF14827.6 VDK72876.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase Aldolase PF01081.19 VDK72876.1 - 0.023 14.1 0.5 0.89 8.9 0.0 2.6 2 1 1 3 3 3 0 KDPG and KHG aldolase DUF3791 PF12668.7 VDK72876.1 - 0.16 12.1 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) HLH PF00010.26 VDK72877.1 - 5.2e-19 67.9 0.5 1.5e-18 66.5 0.1 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HTH_51 PF18558.1 VDK72877.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Prenyltrans PF00432.21 VDK72878.1 - 3.2e-62 205.9 3.4 3.4e-14 52.3 0.1 6.5 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Pkinase PF00069.25 VDK72878.1 - 7.3e-44 150.1 0.3 2.4e-32 112.4 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK72878.1 - 1.9e-23 83.1 0.2 7.6e-17 61.5 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase SQHop_cyclase_N PF13249.6 VDK72878.1 - 1.1e-07 31.3 0.0 0.018 14.2 0.0 4.6 3 2 2 5 5 5 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 VDK72878.1 - 0.00013 21.2 0.0 0.083 12.0 0.0 3.2 1 1 2 3 3 3 2 Squalene-hopene cyclase C-terminal domain Kdo PF06293.14 VDK72878.1 - 0.0026 17.2 0.0 0.0058 16.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SKA2 PF16740.5 VDK72878.1 - 0.012 15.3 1.6 0.052 13.3 1.6 2.1 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 zf-C4H2 PF10146.9 VDK72878.1 - 0.037 14.3 2.9 0.11 12.8 2.9 1.8 1 0 0 1 1 1 0 Zinc finger-containing protein YrbL-PhoP_reg PF10707.9 VDK72878.1 - 0.065 12.7 0.0 0.17 11.3 0.0 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kinase-like PF14531.6 VDK72878.1 - 0.076 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 Kinase-like TSC22 PF01166.18 VDK72878.1 - 0.1 13.0 0.1 0.71 10.2 0.0 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family APH PF01636.23 VDK72878.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family CCDC-167 PF15188.6 VDK72878.1 - 4.1 7.8 10.6 0.29 11.5 3.5 2.8 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 PRK PF00485.18 VDK72879.1 - 1.2e-49 168.8 0.1 1.6e-49 168.4 0.1 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Evr1_Alr PF04777.13 VDK72879.1 - 4.4e-28 97.7 0.1 1.3e-27 96.2 0.1 1.8 1 0 0 1 1 1 1 Erv1 / Alr family CoaE PF01121.20 VDK72879.1 - 9.2e-06 25.5 0.1 0.12 12.0 0.0 2.3 2 0 0 2 2 2 2 Dephospho-CoA kinase AAA_18 PF13238.6 VDK72879.1 - 1.3e-05 25.8 0.1 2.4e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 VDK72879.1 - 0.00051 19.4 0.0 0.001 18.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 VDK72879.1 - 0.0029 17.8 0.0 0.0077 16.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 VDK72879.1 - 0.005 16.6 1.0 0.31 10.7 0.1 2.3 1 1 0 2 2 2 1 Cytidylate kinase AAA_17 PF13207.6 VDK72879.1 - 0.063 13.7 3.9 1.2 9.5 3.9 2.3 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 VDK72879.1 - 0.097 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein T2SSE PF00437.20 VDK72879.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Ribosomal_L7Ae PF01248.26 VDK72880.1 - 6.4e-25 86.7 0.1 7.5e-25 86.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.6 VDK72880.1 - 0.036 14.2 0.0 0.048 13.8 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Galactosyl_T PF01762.21 VDK72881.1 - 1.4e-27 96.8 0.0 1.8e-27 96.4 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 VDK72881.1 - 0.13 11.7 0.0 0.5 9.7 0.0 1.8 1 1 0 1 1 1 0 Fringe-like Glycos_transf_1 PF00534.20 VDK72882.1 - 7.4e-23 80.9 0.0 1.3e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 VDK72882.1 - 5.8e-12 45.9 0.1 1.4e-11 44.7 0.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 VDK72882.1 - 4.6e-11 43.3 0.0 8.3e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 VDK72882.1 - 7.8e-06 26.4 0.0 3.1e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 VDK72882.1 - 0.0059 16.7 1.1 5.9 6.9 0.0 3.1 3 1 1 4 4 4 2 ALG11 mannosyltransferase N-terminus CN_hydrolase PF00795.22 VDK72882.1 - 0.046 13.0 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Carbon-nitrogen hydrolase NPDC1 PF06809.11 VDK72883.1 - 5.1e-17 61.9 0.0 6e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Neural proliferation differentiation control-1 protein (NPDC1) PRELI PF04707.14 VDK72923.1 - 3.2e-46 157.0 0.1 7.7e-46 155.8 0.1 1.7 1 0 0 1 1 1 1 PRELI-like family CRAL_TRIO PF00650.20 VDK72923.1 - 7.4e-40 136.3 0.0 1.4e-39 135.4 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 VDK72923.1 - 6e-06 26.4 0.1 2.4e-05 24.4 0.1 2.1 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DOMON PF03351.17 VDK72925.1 - 3.1e-12 46.8 0.0 4.6e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 DOMON domain RabGAP-TBC PF00566.18 VDK72926.1 - 2.7e-48 164.5 0.2 4.8e-48 163.6 0.2 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RUN PF02759.19 VDK72926.1 - 7e-23 81.1 0.8 1.3e-22 80.3 0.8 1.4 1 0 0 1 1 1 1 RUN domain SH3_1 PF00018.28 VDK72926.1 - 7.8e-11 41.4 0.0 1.6e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK72926.1 - 1.6e-10 40.5 0.1 3.1e-10 39.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 VDK72926.1 - 2.9e-09 36.7 0.0 6.1e-09 35.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RabGAP-TBC PF00566.18 VDK72928.1 - 2.1e-06 27.5 3.2 3.9e-06 26.7 3.2 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 VDK72928.1 - 4.9e-06 27.0 0.0 1.1e-05 26.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Kelch_6 PF13964.6 VDK72929.1 - 2.9e-05 24.2 0.0 0.00013 22.1 0.0 2.2 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 VDK72929.1 - 0.00057 19.8 0.0 0.022 14.7 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Ank_2 PF12796.7 VDK72933.1 - 2.3e-24 85.8 0.9 7.2e-10 39.3 0.3 4.8 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Patatin PF01734.22 VDK72933.1 - 1.3e-22 81.0 0.9 1.1e-21 77.9 0.9 2.3 1 1 0 1 1 1 1 Patatin-like phospholipase Ank_4 PF13637.6 VDK72933.1 - 1.7e-22 79.5 4.0 1.6e-05 25.3 0.0 6.1 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 VDK72933.1 - 5.6e-22 77.2 5.7 8.5e-05 22.8 0.0 7.9 8 0 0 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 VDK72933.1 - 8e-18 64.3 10.9 1.5e-05 25.1 0.2 5.5 5 2 1 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK72933.1 - 6.3e-16 56.9 5.1 0.0045 17.4 0.0 7.2 7 0 0 7 7 7 3 Ankyrin repeat Ribosomal_S5 PF00333.20 VDK72937.1 - 7.5e-24 83.5 0.6 1.6e-23 82.4 0.6 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 VDK72937.1 - 2e-14 52.8 0.0 3.2e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Exo_endo_phos PF03372.23 VDK72940.1 - 4.1e-08 33.0 0.0 9e-08 31.9 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF5640 PF18692.1 VDK72940.1 - 0.16 12.1 0.2 9.5 6.3 0.0 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5640) DUF2982 PF11201.8 VDK72942.1 - 0.096 12.2 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2982) Chorein_N PF12624.7 VDK72943.1 - 3.9e-08 33.4 0.7 1.3e-05 25.3 0.1 2.9 3 0 0 3 3 3 2 N-terminal region of Chorein or VPS13 LRR_8 PF13855.6 VDK72944.1 - 1.5e-56 188.0 30.1 9e-16 57.4 0.5 7.3 2 2 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 VDK72944.1 - 1.2e-26 92.3 32.9 1.2e-07 31.9 0.1 8.1 3 3 6 9 9 9 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK72944.1 - 4.1e-19 68.8 9.1 2.3e-08 34.0 0.1 3.5 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 VDK72944.1 - 3.4e-12 45.1 19.5 1.1 10.0 0.1 10.5 11 0 0 11 11 11 3 Leucine Rich Repeat LRR_9 PF14580.6 VDK72944.1 - 5.8e-10 38.9 16.3 0.005 16.4 0.9 4.9 1 1 3 5 5 5 4 Leucine-rich repeat LRR_6 PF13516.6 VDK72944.1 - 0.00032 20.5 36.2 1 9.6 0.0 9.1 10 0 0 10 10 10 4 Leucine Rich repeat HTH_19 PF12844.7 VDK72944.1 - 0.067 13.2 1.9 0.42 10.7 0.3 2.8 3 0 0 3 3 3 0 Helix-turn-helix domain LRR_8 PF13855.6 VDK72945.1 - 2.4e-78 257.8 85.4 8.5e-16 57.5 1.4 7.5 2 2 8 10 10 10 10 Leucine rich repeat LRR_5 PF13306.6 VDK72945.1 - 4.4e-26 91.3 9.4 2.7e-11 43.5 0.5 3.6 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_4 PF12799.7 VDK72945.1 - 6.2e-26 90.0 49.0 2.6e-05 24.5 0.6 8.5 5 2 6 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK72945.1 - 6.4e-13 47.3 31.0 2 9.3 0.0 12.6 11 1 0 11 11 11 4 Leucine Rich Repeat LRR_9 PF14580.6 VDK72945.1 - 6e-10 38.9 23.9 0.0027 17.3 0.6 5.6 1 1 5 6 6 6 5 Leucine-rich repeat LRR_8 PF13855.6 VDK72948.1 - 4e-54 180.2 85.7 3.6e-13 49.1 6.0 8.0 1 1 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 VDK72948.1 - 5.1e-33 112.5 72.3 3.6e-09 36.8 2.5 8.8 5 1 4 10 10 10 9 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK72948.1 - 2.4e-17 63.1 20.0 4.2e-08 33.2 3.6 4.4 1 1 4 5 5 5 5 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 VDK72948.1 - 1.7e-12 47.2 37.4 5.5e-06 26.0 5.5 4.7 2 1 3 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.33 VDK72948.1 - 2.5e-09 36.4 49.0 0.23 12.1 0.1 13.0 13 0 0 13 13 13 5 Leucine Rich Repeat CS PF04969.16 VDK72951.1 - 0.097 13.7 0.9 6.5 7.8 0.0 2.7 2 0 0 2 2 2 0 CS domain YfhD PF14151.6 VDK72951.1 - 0.12 12.5 1.5 0.24 11.6 1.5 1.5 1 0 0 1 1 1 0 YfhD-like protein PI-PLC-X PF00388.19 VDK72952.1 - 3.6e-57 192.0 0.2 8.8e-57 190.8 0.1 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 VDK72952.1 - 1.2e-35 122.4 0.1 3.4e-34 117.6 0.1 2.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain RA PF00788.23 VDK72952.1 - 3.7e-13 49.9 0.1 1.9e-05 25.2 0.0 3.0 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain EF-hand_like PF09279.11 VDK72952.1 - 2.1e-07 31.3 0.0 1e-06 29.1 0.0 2.3 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like C2 PF00168.30 VDK72952.1 - 4.2e-07 30.2 0.0 1.5e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 C2 domain RasGEF PF00617.19 VDK72952.1 - 1.2e-05 25.6 0.2 0.00013 22.2 0.0 2.6 2 0 0 2 2 2 1 RasGEF domain DUF3124 PF11322.8 VDK72952.1 - 0.0091 16.2 0.2 0.043 14.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3124) Claudin_2 PF13903.6 VDK72983.1 - 3.1e-09 36.9 0.8 3.9e-09 36.5 0.8 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 VDK72983.1 - 0.042 13.7 0.6 0.059 13.2 0.6 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family TMEM174 PF15029.6 VDK72983.1 - 0.12 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 174 GTP_EFTU PF00009.27 VDK72984.1 - 2.3e-22 79.5 0.0 4e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 VDK72984.1 - 1.5e-06 28.4 0.0 1.1e-05 25.7 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 VDK72984.1 - 0.0011 19.1 0.0 0.0029 17.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 VDK72984.1 - 0.0014 18.9 1.4 0.0063 16.8 1.4 2.1 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain RsgA_GTPase PF03193.16 VDK72984.1 - 0.043 13.7 0.1 2.5 8.0 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase RRM_1 PF00076.22 VDK72985.1 - 5.6e-18 64.5 0.1 1e-17 63.7 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PI3_PI4_kinase PF00454.27 VDK72987.1 - 6.1e-42 144.2 0.0 2.7e-41 142.0 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 VDK72987.1 - 2.8e-14 52.6 0.2 1.6e-13 50.2 0.0 2.4 2 0 0 2 2 2 1 FATC domain 7TM_GPCR_Srx PF10328.9 VDK72992.1 - 2.3e-24 86.4 31.1 2.1e-23 83.3 31.1 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7tm_1 PF00001.21 VDK72992.1 - 1.7e-18 66.9 20.8 1.7e-18 66.9 20.8 1.9 1 1 1 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srt PF10321.9 VDK72992.1 - 2.1e-07 30.2 24.8 0.00098 18.2 0.9 2.4 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt Baculo_11_kDa PF06143.11 VDK72992.1 - 0.019 14.5 1.6 0.09 12.4 0.0 2.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family Glyc_hyd_38C_2 PF18230.1 VDK72992.1 - 0.26 11.4 1.4 1.1 9.5 1.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal sub-domain DUF621 PF04789.15 VDK72992.1 - 0.81 8.8 24.1 0.0067 15.6 14.4 2.3 2 1 0 3 3 3 0 Protein of unknown function (DUF621) Ank_2 PF12796.7 VDK72993.1 - 5.8e-32 110.1 2.1 3.6e-11 43.5 0.0 3.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK72993.1 - 5.3e-27 93.8 2.1 3.1e-08 34.0 0.1 4.9 2 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK72993.1 - 2.4e-24 85.1 8.9 1.3e-05 25.4 0.0 5.7 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 VDK72993.1 - 1.5e-22 79.0 13.3 0.00015 22.1 0.1 6.6 6 0 0 6 6 6 6 Ankyrin repeat Ank_3 PF13606.6 VDK72993.1 - 3.7e-18 63.7 8.1 0.01 16.3 0.0 7.1 6 0 0 6 6 6 6 Ankyrin repeat PID PF00640.23 VDK72993.1 - 1.4e-12 47.8 1.3 6.9e-12 45.6 1.3 2.2 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SAM_1 PF00536.30 VDK72993.1 - 1.1e-11 45.0 0.1 4.3e-11 43.1 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK72993.1 - 3.5e-09 36.6 0.1 9e-08 32.1 0.1 2.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SHE3 PF17078.5 VDK72993.1 - 0.032 13.9 0.6 0.078 12.7 0.6 1.6 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 NPA PF16469.5 VDK72993.1 - 0.22 12.1 1.6 2.7 8.6 0.0 2.6 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 Laminin_N PF00055.17 VDK72994.1 - 0.0007 19.3 0.0 0.00089 18.9 0.0 1.2 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) Laminin_N PF00055.17 VDK72995.1 - 2.8e-55 187.5 0.2 2.8e-55 187.5 0.2 2.5 2 1 1 3 3 3 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 VDK72995.1 - 1.5e-14 53.8 36.1 2.4e-08 34.0 10.4 2.9 3 0 0 3 3 3 2 Laminin EGF domain F5_F8_type_C PF00754.25 VDK72995.1 - 0.0043 17.2 0.0 0.0094 16.1 0.0 1.5 2 0 0 2 2 2 1 F5/8 type C domain hEGF PF12661.7 VDK72995.1 - 0.032 14.9 2.4 0.032 14.9 2.4 4.2 3 2 0 3 3 3 0 Human growth factor-like EGF NTR PF01759.21 VDK72999.1 - 1.2e-24 86.2 0.1 1.5e-24 85.9 0.1 1.1 1 0 0 1 1 1 1 UNC-6/NTR/C345C module TIMP PF00965.17 VDK72999.1 - 7.4e-05 22.6 0.1 0.00012 21.9 0.1 1.3 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase UPF0561 PF10573.9 VDK73026.1 - 3.7e-10 40.0 0.6 8.7e-10 38.8 0.6 1.7 2 0 0 2 2 2 1 Uncharacterised protein family UPF0561 QueC PF06508.13 VDK73026.1 - 0.041 13.4 0.1 0.059 12.9 0.1 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC NHL PF01436.21 VDK73028.1 - 7.8e-55 180.3 25.3 5.8e-10 38.7 0.1 7.4 7 0 0 7 7 7 6 NHL repeat DUF5128 PF17170.4 VDK73028.1 - 3.1e-15 56.1 0.3 4.5e-06 26.0 0.0 3.5 1 1 2 3 3 3 3 6-bladed beta-propeller SGL PF08450.12 VDK73028.1 - 1.1e-09 38.3 0.0 0.043 13.4 0.0 4.9 2 1 2 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region Filamin PF00630.19 VDK73028.1 - 2.9e-07 31.3 0.0 7.3e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Filamin/ABP280 repeat zf-B_box PF00643.24 VDK73028.1 - 2.8e-06 27.4 15.9 0.00015 21.8 7.8 4.1 3 1 0 3 3 2 2 B-box zinc finger zf-C3HC4_2 PF13923.6 VDK73028.1 - 0.0032 17.3 11.6 0.0032 17.3 11.6 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) DUF4934 PF16288.5 VDK73028.1 - 0.019 14.9 0.0 0.11 12.4 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4934) DUF1664 PF07889.12 VDK73028.1 - 0.022 14.8 1.5 0.34 11.0 1.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Phytase-like PF13449.6 VDK73028.1 - 0.087 12.7 0.0 13 5.6 0.0 3.1 2 1 1 3 3 3 0 Esterase-like activity of phytase TAF1_subA PF14929.6 VDK73028.1 - 0.17 11.3 0.2 0.26 10.7 0.2 1.2 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A SdiA-regulated PF06977.11 VDK73028.1 - 0.17 11.1 0.0 1.6 7.9 0.0 2.4 1 1 1 2 2 2 0 SdiA-regulated KxDL PF10241.9 VDK73028.1 - 0.55 10.6 2.2 1.1 9.5 2.2 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein DUF883 PF05957.13 VDK73028.1 - 1.1 9.9 3.6 15 6.3 2.5 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) RtcB PF01139.17 VDK73030.1 - 8.2e-146 486.4 0.1 9.4e-146 486.2 0.1 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB tRNA-synt_1 PF00133.22 VDK73031.1 - 8.7e-136 453.6 0.0 1.4e-135 453.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 VDK73031.1 - 1.1e-17 63.9 0.0 3.3e-11 42.6 0.0 3.7 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 VDK73031.1 - 2.4e-15 56.8 0.8 5.9e-15 55.5 0.1 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA MADF_DNA_bdg PF10545.9 VDK73031.1 - 8.1e-12 45.3 0.2 2.5e-11 43.7 0.2 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like PAC3 PF10178.9 VDK73031.1 - 0.0049 17.0 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 Myb_DNA-bind_4 PF13837.6 VDK73031.1 - 0.0092 16.3 0.1 0.022 15.2 0.1 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain tRNA-synt_1f PF01921.18 VDK73031.1 - 0.088 11.7 0.0 0.17 10.8 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (K) Pan3_PK PF18101.1 VDK73032.1 - 0.11 12.4 1.2 0.29 11.1 0.1 2.2 2 0 0 2 2 2 0 Pan3 Pseudokinase domain Sec8_exocyst PF04048.14 VDK73034.1 - 2.2e-10 40.6 0.2 4.6e-10 39.6 0.2 1.6 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 VDK73034.1 - 0.00012 21.5 1.4 0.00016 21.1 1.4 1.1 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex ABC_tran_CTD PF16326.5 VDK73034.1 - 0.079 13.2 0.2 1.1 9.5 0.0 2.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain HR1 PF02185.16 VDK73034.1 - 1.6 8.9 5.6 0.76 9.9 0.4 2.7 3 0 0 3 3 3 0 Hr1 repeat zf-C2H2 PF00096.26 VDK73038.1 - 0.059 13.8 0.3 0.16 12.4 0.3 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type I-set PF07679.16 VDK73040.1 - 1.9e-13 50.3 0.0 6e-13 48.7 0.0 1.8 2 1 1 3 3 3 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK73040.1 - 2.9e-12 47.0 0.1 7e-12 45.8 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 VDK73040.1 - 2.7e-07 30.7 0.8 4.3e-07 30.0 0.2 1.6 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 VDK73040.1 - 7.4e-07 29.4 0.0 1.6e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 VDK73040.1 - 4.1e-05 23.7 0.5 0.00064 19.9 0.5 2.4 1 1 0 1 1 1 1 Immunoglobulin V-set domain Cadherin_C_2 PF16492.5 VDK73040.1 - 0.02 15.6 0.4 0.1 13.3 0.2 2.2 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal LapA_dom PF06305.11 VDK73040.1 - 0.028 14.2 1.5 0.041 13.7 0.3 1.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Shisa PF13908.6 VDK73040.1 - 0.13 12.5 0.1 0.36 11.1 0.0 1.7 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Calcipressin PF04847.12 VDK73041.1 - 0.017 14.9 0.0 4.3 7.0 0.0 2.1 2 0 0 2 2 2 0 Calcipressin Adeno_knob PF00541.17 VDK73041.1 - 0.05 13.3 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Adenoviral fibre protein (knob domain) GlgS PF08971.11 VDK73041.1 - 0.12 12.4 0.1 1.3 9.1 0.0 2.5 3 0 0 3 3 3 0 Glycogen synthesis protein ATG22 PF11700.8 VDK73041.1 - 0.12 11.0 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like Macoilin PF09726.9 VDK73047.1 - 9.1e-109 364.9 40.6 4.8e-70 237.0 21.2 2.3 2 0 0 2 2 2 2 Macoilin family Arg_decarbox_C PF17944.1 VDK73047.1 - 0.02 15.4 1.5 0.02 15.4 1.5 3.0 3 0 0 3 3 3 0 Arginine decarboxylase C-terminal helical extension WD40 PF00400.32 VDK73049.1 - 6.8e-09 36.2 6.2 0.007 17.2 0.0 5.2 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK73049.1 - 2.9e-06 27.5 1.2 3.7 7.9 0.0 5.0 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 VDK73049.1 - 0.0046 16.1 0.1 0.43 9.6 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1513) CPW_WPC PF09717.10 VDK73049.1 - 0.24 12.4 1.5 0.49 11.4 1.5 1.4 1 0 0 1 1 1 0 Plasmodium falciparum domain of unknown function (CPW_WPC) MRP-S33 PF08293.11 VDK73051.1 - 9.4e-17 61.0 0.3 1.3e-16 60.6 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Josephin PF02099.17 VDK73053.1 - 1.3e-24 87.1 0.2 4.4e-23 82.2 0.2 2.1 1 1 0 1 1 1 1 Josephin Cas_Csy3 PF09615.10 VDK73053.1 - 0.03 13.7 0.1 0.037 13.4 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy3) TRC8_N PF13705.6 VDK73054.1 - 2.7e-73 247.6 36.9 3.2e-73 247.3 36.9 1.0 1 0 0 1 1 1 1 TRC8 N-terminal domain zf-RING_2 PF13639.6 VDK73054.1 - 5.9e-10 39.3 9.7 2.2e-09 37.5 9.7 2.1 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK73054.1 - 2.4e-08 33.7 10.9 7.6e-08 32.1 10.9 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK73054.1 - 1.9e-07 30.8 9.8 5e-07 29.5 9.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 VDK73054.1 - 1.2e-06 28.1 4.3 1.2e-06 28.1 4.3 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 VDK73054.1 - 1.4e-06 28.5 10.4 5.2e-06 26.6 10.4 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 VDK73054.1 - 0.00031 20.6 8.2 0.00089 19.2 8.2 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 VDK73054.1 - 0.002 18.1 4.7 0.0079 16.2 4.7 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK73054.1 - 0.008 16.0 10.4 0.022 14.6 10.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK73054.1 - 0.013 15.5 3.8 0.038 14.0 3.8 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 VDK73054.1 - 0.014 15.2 3.0 0.056 13.3 3.0 2.0 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 VDK73054.1 - 0.045 13.6 10.6 0.11 12.4 10.6 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 VDK73054.1 - 0.25 11.0 9.8 0.39 10.4 7.7 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 VDK73054.1 - 6.7 6.9 9.6 19 5.5 9.6 1.8 1 0 0 1 1 1 0 RING-variant domain Ribosomal_L19 PF01245.20 VDK73056.1 - 4.9e-16 58.6 0.1 4.9e-16 58.6 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L19 Kelch_1 PF01344.25 VDK73057.1 - 1e-87 287.5 24.9 5.1e-17 61.2 0.3 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 VDK73057.1 - 3.5e-35 119.1 5.3 8.8e-07 29.0 0.0 6.8 4 1 3 7 7 7 5 Kelch motif Kelch_2 PF07646.15 VDK73057.1 - 4.9e-33 111.9 5.2 4.8e-06 26.3 0.0 6.6 6 0 0 6 6 6 6 Kelch motif BTB PF00651.31 VDK73057.1 - 1.8e-32 111.8 0.8 3.2e-32 111.0 0.8 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 VDK73057.1 - 2e-32 111.3 2.1 3e-32 110.8 0.7 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_4 PF13418.6 VDK73057.1 - 1.1e-22 79.7 3.9 5.7e-05 23.0 0.0 6.2 3 1 3 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 VDK73057.1 - 8.7e-21 73.7 15.6 0.0008 19.6 0.5 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 VDK73057.1 - 1.7e-06 27.9 6.1 1.3 9.1 0.1 5.3 5 0 0 5 5 5 2 Kelch motif Glu_cyclase_2 PF05096.12 VDK73057.1 - 0.0017 17.9 0.0 0.21 11.0 0.0 2.4 1 1 1 2 2 2 1 Glutamine cyclotransferase PQQ_3 PF13570.6 VDK73057.1 - 0.027 14.9 14.8 0.64 10.6 0.2 5.7 6 0 0 6 6 6 0 PQQ-like domain DUF3342 PF11822.8 VDK73057.1 - 0.028 14.6 1.4 0.3 11.3 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3342) DUF2754 PF10953.8 VDK73059.1 - 0.024 14.9 0.1 0.035 14.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) TOM6p PF15184.6 VDK73059.1 - 0.15 11.8 0.1 0.31 10.8 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit TOM6 homolog PK PF00224.21 VDK73061.1 - 4.8e-160 532.1 2.7 5.9e-160 531.8 2.7 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 VDK73061.1 - 1.9e-30 105.5 0.0 6.3e-30 103.8 0.0 1.9 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 VDK73061.1 - 0.0012 18.1 0.6 0.0031 16.7 0.7 1.7 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family CoA_binding_3 PF13727.6 VDK73062.1 - 0.13 12.2 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 CoA-binding domain PK PF00224.21 VDK73063.1 - 1.9e-158 526.9 3.0 2.4e-158 526.5 3.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 VDK73063.1 - 1.2e-33 115.8 0.1 4.1e-33 114.1 0.1 2.0 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 VDK73063.1 - 4.6e-06 25.9 0.2 8.5e-06 25.1 0.2 1.5 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 VDK73063.1 - 0.037 13.0 0.2 0.13 11.3 0.0 1.9 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain EGF_2 PF07974.13 VDK73085.1 - 1.4e-09 38.1 34.5 4e-07 30.3 9.9 5.7 4 1 2 6 6 6 2 EGF-like domain I-EGF_1 PF18372.1 VDK73085.1 - 1.2e-07 31.6 27.2 1.5e-05 25.0 7.9 5.1 5 1 0 5 5 5 3 Integrin beta epidermal growth factor like domain 1 EGF_Tenascin PF18720.1 VDK73085.1 - 0.68 10.0 25.7 0.37 10.9 11.5 3.3 2 0 0 2 2 2 0 Tenascin EGF domain MFS_1 PF07690.16 VDK73088.1 - 1.1e-35 123.3 78.3 1e-27 97.0 42.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 VDK73088.1 - 0.00023 20.1 35.3 0.00026 20.0 2.4 3.7 2 2 2 4 4 4 3 MFS_1 like family UPF0060 PF02694.15 VDK73088.1 - 0.017 15.4 0.3 0.017 15.4 0.3 3.5 3 0 0 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family FERM_C PF09380.10 VDK73089.1 - 1.7e-22 79.6 1.9 5e-22 78.1 1.9 1.8 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 VDK73089.1 - 1.4e-14 53.7 0.0 3.2e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain RhoGEF PF00621.20 VDK73089.1 - 7.2e-10 39.4 0.3 7.2e-10 39.4 0.3 1.9 2 0 0 2 2 2 1 RhoGEF domain FA PF08736.11 VDK73089.1 - 1.3e-09 37.9 6.3 4.1e-09 36.4 6.3 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) FERM_M PF00373.18 VDK73089.1 - 2.2e-09 37.7 0.0 5.7e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 FERM central domain PH PF00169.29 VDK73089.1 - 2.7e-07 31.0 0.5 0.00084 19.8 0.0 3.1 3 0 0 3 3 3 2 PH domain Stevor PF17410.2 VDK73089.1 - 9.1 5.7 7.3 19 4.7 6.7 1.8 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame PIG-X PF08320.12 VDK73092.1 - 3.4e-15 56.5 0.1 4e-15 56.3 0.1 1.1 1 0 0 1 1 1 1 PIG-X / PBN1 Pkinase PF00069.25 VDK73095.1 - 7.7e-68 228.7 0.0 9.4e-68 228.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK73095.1 - 7.9e-46 156.4 0.0 1e-45 156.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK73095.1 - 7.5e-08 32.0 0.1 7.9e-07 28.7 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDK73095.1 - 2e-07 30.1 0.0 5.1e-07 28.8 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 VDK73095.1 - 3.6e-05 22.9 0.2 7.4e-05 21.8 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 VDK73095.1 - 0.0042 16.4 0.1 0.0072 15.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PIP49_C PF12260.8 VDK73095.1 - 0.017 14.7 0.4 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 FTA2 PF13095.6 VDK73095.1 - 0.02 14.5 1.5 0.27 10.8 0.6 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 VDK73095.1 - 0.094 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family SNAP PF14938.6 VDK73098.1 - 1.3e-05 24.7 0.7 0.00012 21.6 0.7 2.1 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 VDK73098.1 - 0.054 14.0 3.7 1.5 9.4 1.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat NSF PF02071.20 VDK73098.1 - 0.19 12.5 2.6 67 5.0 0.1 4.2 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_12 PF13424.6 VDK73098.1 - 0.33 11.3 4.8 0.78 10.1 1.8 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Med22 PF06179.12 VDK73099.1 - 5.1e-20 71.7 0.6 7.2e-20 71.2 0.6 1.3 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Mito_carr PF00153.27 VDK73100.1 - 2.4e-70 232.5 0.1 1.7e-24 85.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 VDK73100.1 - 4.9e-18 65.3 0.0 7.9e-08 32.7 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK73100.1 - 4.8e-12 44.5 5.1 0.00014 21.1 0.1 4.3 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 VDK73100.1 - 5.2e-12 44.7 3.5 7.1e-05 22.4 0.1 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 VDK73100.1 - 4.4e-07 29.1 1.6 0.0098 15.4 0.2 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 VDK73100.1 - 7.6e-07 28.9 3.0 0.0086 15.9 0.5 4.2 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_9 PF14658.6 VDK73100.1 - 0.0023 18.2 0.0 0.39 11.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain RRM_1 PF00076.22 VDK73102.1 - 9.9e-10 38.1 0.2 4.5e-09 36.0 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK73102.1 - 3.8e-05 23.3 0.0 8.2e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 VDK73102.1 - 0.017 15.2 0.0 0.052 13.6 0.0 1.9 1 0 0 1 1 1 0 Limkain b1 RRM_3 PF08777.11 VDK73102.1 - 0.024 14.7 0.2 0.11 12.5 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.6 VDK73102.1 - 0.12 12.4 0.2 0.25 11.4 0.2 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-C4 PF00105.18 VDK73104.1 - 2.1e-30 105.0 17.3 2.1e-30 105.0 17.3 2.0 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK73104.1 - 1.6e-26 93.2 2.4 7e-26 91.1 2.4 1.9 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor ADH_zinc_N PF00107.26 VDK73106.1 - 3.3e-19 69.2 0.0 5.9e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 VDK73106.1 - 3.4e-08 33.3 0.0 1.9e-07 30.9 0.0 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 VDK73106.1 - 3.5e-05 24.9 0.0 7.2e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CoA_binding_2 PF13380.6 VDK73106.1 - 0.00061 20.3 0.0 0.11 13.0 0.0 2.5 1 1 0 1 1 1 1 CoA binding domain Med22 PF06179.12 VDK73106.1 - 0.076 13.2 0.2 3.5 7.9 0.1 2.4 2 0 0 2 2 2 0 Surfeit locus protein 5 subunit 22 of Mediator complex DNA_photolyase PF00875.18 VDK73106.1 - 0.1 12.6 0.1 4.8 7.2 0.0 2.3 1 1 1 2 2 2 0 DNA photolyase Terminase_6C PF17289.2 VDK73106.1 - 0.15 12.1 0.1 4.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Terminase RNaseH-like domain Vps53_N PF04100.12 VDK73148.1 - 1.6e-109 366.4 4.9 3.1e-109 365.4 4.9 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal VPS53_C PF16854.5 VDK73148.1 - 3.6e-06 27.0 0.8 3.8e-05 23.7 0.1 2.7 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 53 C-terminus Baculo_PEP_C PF04513.12 VDK73148.1 - 0.0063 16.6 10.1 0.35 10.9 0.3 3.9 3 1 0 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus GlutR_N PF05201.15 VDK73148.1 - 0.48 10.2 3.1 0.71 9.6 0.1 2.8 4 0 0 4 4 4 0 Glutamyl-tRNAGlu reductase, N-terminal domain MH2 PF03166.14 VDK73149.1 - 2.1e-63 213.9 0.8 3e-63 213.4 0.8 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 VDK73149.1 - 1.2e-39 134.6 2.6 2.8e-39 133.5 2.6 1.6 1 0 0 1 1 1 1 MH1 domain Nuc_sug_transp PF04142.15 VDK73150.1 - 6.1e-104 347.6 20.8 7.3e-104 347.3 20.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 VDK73150.1 - 0.0015 17.8 14.0 0.0035 16.6 12.7 2.3 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport EamA PF00892.20 VDK73150.1 - 0.002 18.3 10.5 0.002 18.3 10.5 3.0 2 1 0 2 2 2 1 EamA-like transporter family WD40 PF00400.32 VDK73151.1 - 3.1e-26 91.1 33.6 7.8e-07 29.7 0.1 9.1 9 1 0 9 9 9 5 WD domain, G-beta repeat Hira PF07569.11 VDK73151.1 - 5.2e-25 88.5 6.6 3.1e-23 82.7 3.5 2.9 2 1 0 2 2 2 1 TUP1-like enhancer of split ANAPC4_WD40 PF12894.7 VDK73151.1 - 5.1e-11 42.7 0.7 0.044 14.1 0.1 5.9 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 VDK73151.1 - 0.00018 21.3 0.1 0.00046 19.9 0.1 1.7 1 0 0 1 1 1 1 HIRA B motif WD40_like PF17005.5 VDK73151.1 - 0.019 14.3 0.1 5.5 6.2 0.0 3.0 3 0 0 3 3 3 0 WD40-like domain PD40 PF07676.12 VDK73151.1 - 0.028 14.4 2.7 14 5.7 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PAP_assoc PF03828.19 VDK73153.1 - 4.8e-20 71.5 0.0 7.8e-16 58.0 0.0 3.0 2 0 0 2 2 2 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 VDK73153.1 - 4e-06 27.0 0.0 0.027 14.7 0.0 2.9 2 0 0 2 2 2 2 Nucleotidyltransferase domain zf-CCHC PF00098.23 VDK73153.1 - 0.00077 19.4 14.6 0.0023 17.9 3.1 2.8 2 0 0 2 2 2 2 Zinc knuckle RNA_pol_L_2 PF13656.6 VDK73153.1 - 0.044 13.5 0.5 28 4.6 0.1 3.3 3 0 0 3 3 3 0 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-CCHC_4 PF14392.6 VDK73153.1 - 3.7 7.4 12.3 4.2 7.2 3.8 2.9 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_jaz PF12171.8 VDK73153.1 - 9.3 6.7 9.8 0.74 10.2 2.4 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Na_H_Exchanger PF00999.21 VDK73156.1 - 2.1e-20 72.9 11.6 2.1e-20 72.9 11.6 2.8 2 1 1 3 3 3 1 Sodium/hydrogen exchanger family BRICHOS PF04089.14 VDK73157.1 - 0.0083 16.4 0.0 0.041 14.1 0.0 2.3 1 1 0 1 1 1 1 BRICHOS domain NAD_Gly3P_dh_N PF01210.23 VDK73159.1 - 6.7e-52 175.6 0.2 1.1e-51 174.9 0.2 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 VDK73159.1 - 8e-46 155.8 0.2 1.8e-45 154.7 0.2 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 VDK73159.1 - 0.0019 18.7 0.2 0.05 14.2 0.0 2.8 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent zf-CXXC PF02008.20 VDK73163.1 - 2.7e-16 59.3 40.9 7.5e-12 45.1 21.0 2.3 2 0 0 2 2 2 2 CXXC zinc finger domain CUT PF02376.15 VDK73165.1 - 5.4e-73 241.2 0.1 8.6e-25 86.7 0.0 3.7 3 0 0 3 3 3 3 CUT domain Homeodomain PF00046.29 VDK73165.1 - 2.3e-15 56.2 3.8 8e-15 54.4 3.8 2.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK73165.1 - 0.0081 16.0 4.0 0.016 15.1 0.3 2.9 3 0 0 3 3 3 1 Homeobox KN domain HTH_23 PF13384.6 VDK73165.1 - 0.011 15.5 0.0 0.04 13.7 0.0 2.0 1 0 0 1 1 1 0 Homeodomain-like domain HTH_34 PF13601.6 VDK73165.1 - 0.02 15.0 0.0 1.1 9.5 0.0 3.2 3 0 0 3 3 3 0 Winged helix DNA-binding domain HTH_11 PF08279.12 VDK73165.1 - 0.42 10.6 2.7 1.2 9.1 0.1 2.8 2 0 0 2 2 2 0 HTH domain Cmc1 PF08583.10 VDK73166.1 - 1.4e-05 25.1 3.1 4.1e-05 23.5 0.8 2.3 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like GCK PF07802.11 VDK73166.1 - 0.029 14.8 0.7 0.076 13.4 0.1 1.9 2 0 0 2 2 2 0 GCK domain CHCH PF06747.13 VDK73166.1 - 0.14 12.3 4.0 0.35 11.1 0.4 2.6 2 0 0 2 2 2 0 CHCH domain JHBP PF06585.11 VDK73166.1 - 0.15 11.2 0.1 0.31 10.2 0.1 1.6 1 1 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) CX9C PF16860.5 VDK73166.1 - 0.4 10.7 6.1 0.097 12.7 1.7 2.1 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, PDZ_2 PF13180.6 VDK73168.1 - 0.0014 18.9 0.0 0.049 14.0 0.0 2.3 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 VDK73168.1 - 0.0077 16.6 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK73168.1 - 0.086 12.7 0.0 0.32 10.9 0.0 1.9 2 0 0 2 2 2 0 PDZ domain CD36 PF01130.21 VDK73193.1 - 9.2e-105 350.9 0.0 1.1e-104 350.6 0.0 1.0 1 0 0 1 1 1 1 CD36 family DUF4064 PF13273.6 VDK73193.1 - 0.025 14.9 0.4 11 6.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) PorA PF11271.8 VDK73193.1 - 0.44 9.8 1.0 3.3 6.9 0.0 2.6 2 1 1 3 3 3 0 Porin PorA Sigma_reg_N PF13800.6 VDK73193.1 - 0.47 10.8 5.2 7.2 7.0 1.0 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal CRPA PF05745.11 VDK73193.1 - 2.6 8.0 8.3 0.23 11.5 0.6 2.3 2 0 0 2 2 2 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Thioredoxin PF00085.20 VDK73194.1 - 2.2e-11 43.7 0.0 4.5e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin HLH PF00010.26 VDK73195.1 - 1.1e-19 70.1 3.2 2.1e-19 69.2 3.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Exo_endo_phos PF03372.23 VDK73196.1 - 3e-10 40.0 0.0 5.4e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF5637 PF18687.1 VDK73196.1 - 0.067 13.2 0.0 0.19 11.8 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5637) fn1 PF00039.18 VDK73198.1 - 0.8 9.9 9.2 18 5.6 0.5 3.7 3 0 0 3 3 3 0 Fibronectin type I domain UCR_6-4kD PF08997.10 VDK73199.1 - 0.0042 17.0 0.4 0.0058 16.5 0.1 1.4 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase complex, 6.4kD protein HipN PF18253.1 VDK73200.1 - 3.8e-17 61.7 0.1 7.1e-17 60.8 0.1 1.5 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain TPR_1 PF00515.28 VDK73200.1 - 8.5e-16 57.0 0.6 4e-05 23.3 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 VDK73200.1 - 5.1e-15 54.3 1.2 0.001 19.0 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 VDK73200.1 - 2.8e-07 30.1 0.4 0.00043 19.9 0.0 3.3 2 1 2 4 4 4 2 TPR repeat TPR_17 PF13431.6 VDK73200.1 - 2.6e-06 27.4 0.3 0.0016 18.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK73200.1 - 2.9e-06 27.6 0.1 2.1 9.4 0.0 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 VDK73200.1 - 2.7e-05 24.0 0.5 0.35 11.2 0.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK73200.1 - 0.00019 22.0 0.1 0.0034 18.0 0.2 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK73200.1 - 0.00029 21.3 0.2 0.0013 19.2 0.0 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK73200.1 - 0.00086 19.6 0.8 0.028 14.7 0.7 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK73200.1 - 0.0028 17.8 0.2 0.16 12.1 0.2 2.4 1 1 2 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 VDK73200.1 - 0.053 13.6 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain STI1 PF17830.1 VDK73202.1 - 6.3e-15 54.9 0.9 9.4e-15 54.3 0.9 1.3 1 0 0 1 1 1 1 STI1 domain EcsC PF12787.7 VDK73202.1 - 0.019 14.7 0.1 0.038 13.7 0.0 1.5 2 0 0 2 2 2 0 EcsC protein family DUF5401 PF17380.2 VDK73202.1 - 6.9 4.6 10.7 9.1 4.2 10.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF1604 PF07713.13 VDK73203.1 - 4.2e-37 125.8 0.5 2e-36 123.7 0.5 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1604) G-patch PF01585.23 VDK73203.1 - 3.5e-08 33.2 1.8 8.8e-08 31.9 1.8 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 VDK73203.1 - 0.0025 17.9 0.3 0.0081 16.2 0.3 1.9 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 VDK73204.1 - 4.8e-19 67.9 0.1 9.3e-19 67.0 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK73204.1 - 0.00032 20.3 0.0 0.00061 19.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK73204.1 - 0.0017 18.3 0.1 0.0031 17.5 0.1 1.4 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 VDK73204.1 - 0.035 14.1 0.1 0.13 12.3 0.1 2.0 1 1 1 2 2 2 0 Nup53/35/40-type RNA recognition motif RL PF17797.1 VDK73204.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 RL domain SNF5 PF04855.12 VDK73205.1 - 5.5e-50 170.4 0.1 8.3e-25 87.9 0.0 2.1 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 CRC_subunit PF08624.10 VDK73205.1 - 0.077 13.4 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Chromatin remodelling complex Rsc7/Swp82 subunit UPF0121 PF03661.13 VDK73207.1 - 6.6e-78 261.4 13.9 7.8e-78 261.2 13.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) FARP PF01581.16 VDK73208.1 - 0.00015 21.6 8.3 2.8 8.8 0.2 3.4 3 0 0 3 3 3 3 FMRFamide related peptide family DDDD PF10161.9 VDK73208.1 - 0.042 13.6 0.0 0.075 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative mitochondrial precursor protein TubC_N PF18563.1 VDK73208.1 - 0.08 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 TubC N-terminal docking domain zf-RING_12 PF17976.1 VDK73209.1 - 3.2e-14 53.0 12.8 3.2e-14 53.0 12.8 3.2 3 1 0 3 3 3 1 RING/Ubox like zinc-binding domain zf-RING_14 PF17978.1 VDK73209.1 - 1.1e-11 45.0 13.3 1.1e-11 45.0 13.3 4.8 3 2 2 5 5 5 1 RING/Ubox like zinc-binding domain IBR PF01485.21 VDK73209.1 - 9.2e-10 38.6 28.1 4.3e-06 26.9 15.1 5.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain ubiquitin PF00240.23 VDK73209.1 - 0.0085 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Pescadillo_N PF06732.11 VDK73210.1 - 7.2e-114 380.0 5.0 7.2e-114 380.0 5.0 1.6 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 VDK73210.1 - 3.9e-10 40.0 0.0 1.3e-09 38.4 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Ribosomal_L6 PF00347.23 VDK73212.1 - 3.1e-34 117.5 3.9 1.9e-19 70.1 1.2 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 CENP-W PF15510.6 VDK73212.1 - 0.11 12.7 0.6 1.8 8.8 0.1 2.3 2 0 0 2 2 2 0 CENP-W protein HSP20 PF00011.21 VDK73214.1 - 3.4e-13 49.6 0.0 5.7e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK73214.1 - 0.093 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Peptidase_M16 PF00675.20 VDK73215.1 - 6.1e-44 149.6 0.2 1.1e-43 148.8 0.2 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 VDK73215.1 - 2.3e-27 96.2 0.0 9.4e-25 87.7 0.0 2.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain YcgR PF07317.12 VDK73215.1 - 0.084 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Flagellar regulator YcgR HBS1_N PF08938.10 VDK73215.1 - 0.12 12.7 0.1 0.32 11.3 0.1 1.7 1 0 0 1 1 1 0 HBS1 N-terminus UCR_TM PF02921.14 VDK73216.1 - 2.2e-16 60.1 0.6 5e-16 58.9 0.6 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 VDK73216.1 - 7.5e-13 48.2 0.0 1.9e-12 46.9 0.0 1.7 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain RimM PF01782.18 VDK73216.1 - 0.064 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 RimM N-terminal domain HPS3_Mid PF14762.6 VDK73216.1 - 0.095 11.4 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3, middle region R3H PF01424.22 VDK73217.1 - 3.4e-11 43.0 0.1 8.1e-11 41.8 0.1 1.7 1 0 0 1 1 1 1 R3H domain DSS1_SEM1 PF05160.13 VDK73220.1 - 3.3e-18 65.5 21.2 4.6e-18 65.0 21.2 1.2 1 0 0 1 1 1 1 DSS1/SEM1 family NOA36 PF06524.12 VDK73220.1 - 0.077 12.3 6.0 0.092 12.1 6.0 1.0 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 VDK73220.1 - 2.2 6.3 11.5 2.4 6.1 11.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi Tim44 PF04280.15 VDK73222.1 - 8.3e-21 74.6 0.1 1.3e-20 74.0 0.1 1.2 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 VDK73222.1 - 2.8e-06 26.6 0.0 5.3e-06 25.7 0.0 1.4 1 1 0 1 1 1 1 MBA1-like protein Lig_chan-Glu_bd PF10613.9 VDK73224.1 - 6.6e-38 129.4 0.0 1.2e-37 128.6 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site ANF_receptor PF01094.28 VDK73224.1 - 3.4e-14 52.7 0.1 4.6e-14 52.3 0.1 1.1 1 0 0 1 1 1 1 Receptor family ligand binding region SBP_bac_3 PF00497.20 VDK73224.1 - 3.9e-11 42.8 0.0 9.7e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 S10_plectin PF03501.15 VDK73224.1 - 0.058 13.5 0.1 2.6 8.2 0.1 2.6 2 0 0 2 2 2 0 Plectin/S10 domain Patched PF02460.18 VDK73277.1 - 1.8e-190 635.0 16.5 2e-190 634.8 16.5 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK73277.1 - 1.3e-36 125.7 17.4 7e-35 120.1 5.7 3.4 2 1 1 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK73277.1 - 0.0002 20.4 3.1 0.0002 20.4 3.1 2.1 2 0 0 2 2 2 1 MMPL family SecD_SecF PF02355.16 VDK73277.1 - 0.006 16.0 10.8 0.006 16.0 10.8 2.7 3 1 0 3 3 3 1 Protein export membrane protein Patched PF02460.18 VDK73279.1 - 5.3e-14 51.3 0.0 6.1e-14 51.1 0.0 1.0 1 0 0 1 1 1 1 Patched family KorB PF08535.10 VDK73279.1 - 0.086 12.9 0.0 0.23 11.5 0.0 1.7 1 1 0 1 1 1 0 KorB domain Kunitz_BPTI PF00014.23 VDK73280.1 - 1.4e-98 323.0 75.7 1e-17 64.1 3.7 7.9 7 0 0 7 7 7 7 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 VDK73280.1 - 1.1e-52 176.2 116.1 2.2e-09 37.6 7.8 9.1 9 0 0 9 9 9 7 Lustrin, cysteine-rich repeated domain Pep_M12B_propep PF01562.19 VDK73282.1 - 0.0059 16.8 0.2 0.0082 16.4 0.2 1.3 1 0 0 1 1 1 1 Reprolysin family propeptide TSP_1 PF00090.19 VDK73283.1 - 8.5e-33 112.3 130.3 2.5e-08 34.0 12.0 10.7 9 1 2 11 11 11 6 Thrombospondin type 1 domain Reprolysin PF01421.19 VDK73283.1 - 2e-19 70.3 0.2 5.9e-19 68.8 0.2 1.8 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 VDK73283.1 - 1.9e-10 41.2 5.4 1.9e-10 41.2 1.1 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12 Pep_M12B_propep PF01562.19 VDK73283.1 - 1.6e-05 25.2 0.0 3.6e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_3 PF13582.6 VDK73283.1 - 1.8e-05 25.2 0.3 3.8e-05 24.2 0.3 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 VDK73283.1 - 0.00056 19.9 0.9 0.0016 18.4 0.9 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 VDK73283.1 - 0.0014 18.3 0.2 0.0032 17.1 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 VDK73283.1 - 0.15 12.6 0.0 0.041 14.4 6.3 8.2 7 2 1 8 8 8 0 ADAM cysteine-rich domain Myosin_head PF00063.21 VDK73284.1 - 2e-145 485.7 3.4 1e-107 361.1 0.4 3.2 2 1 1 3 3 3 3 Myosin head (motor domain) MyTH4 PF00784.17 VDK73284.1 - 5.8e-58 194.1 2.8 5.6e-30 104.0 0.3 3.5 4 0 0 4 4 4 2 MyTH4 domain FERM_M PF00373.18 VDK73284.1 - 6.2e-22 78.2 0.9 5.8e-12 46.0 0.0 3.1 2 0 0 2 2 2 2 FERM central domain FERM_N PF09379.10 VDK73284.1 - 7.3e-07 29.0 0.1 0.042 13.8 0.0 2.6 2 0 0 2 2 2 2 FERM N-terminal domain AAA_22 PF13401.6 VDK73284.1 - 0.0026 18.0 0.0 0.062 13.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain IRS PF02174.17 VDK73284.1 - 0.021 14.7 0.0 0.061 13.2 0.0 1.8 1 0 0 1 1 1 0 PTB domain (IRS-1 type) AAA_16 PF13191.6 VDK73284.1 - 0.055 13.9 0.0 0.35 11.2 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 VDK73284.1 - 0.11 13.0 0.4 0.43 11.1 0.0 2.1 2 0 0 2 2 2 0 ABC transporter IQ PF00612.27 VDK73284.1 - 0.33 10.9 10.9 0.1 12.5 0.2 3.9 3 0 0 3 3 3 0 IQ calmodulin-binding motif Patched PF02460.18 VDK73285.1 - 3.4e-78 263.6 32.6 5e-51 173.7 8.3 2.2 2 0 0 2 2 2 2 Patched family NPC1_N PF16414.5 VDK73285.1 - 3.6e-63 213.4 14.6 7.6e-63 212.3 14.6 1.5 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 VDK73285.1 - 9.9e-51 171.6 6.6 9.9e-51 171.6 6.6 3.4 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation Folate_rec PF03024.14 VDK73285.1 - 0.00011 22.1 2.9 0.00039 20.3 2.9 1.9 1 0 0 1 1 1 1 Folate receptor family Nse4-Nse3_bdg PF15412.6 VDK73286.1 - 0.011 15.8 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE SH2 PF00017.24 VDK73288.1 - 7.8e-15 54.7 0.5 1.7e-14 53.7 0.5 1.6 1 0 0 1 1 1 1 SH2 domain RasGEF PF00617.19 VDK73288.1 - 0.0023 18.2 0.1 0.0043 17.3 0.1 1.4 1 0 0 1 1 1 1 RasGEF domain Ion_trans_2 PF07885.16 VDK73290.1 - 2.1e-13 50.0 3.7 5e-13 48.8 3.7 1.7 1 0 0 1 1 1 1 Ion channel BK_channel_a PF03493.18 VDK73290.1 - 2.6e-08 34.0 0.1 6.6e-08 32.6 0.1 1.7 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit TrkA_N PF02254.18 VDK73290.1 - 0.00073 19.8 0.0 0.44 10.8 0.0 2.5 2 0 0 2 2 2 2 TrkA-N domain Ion_trans PF00520.31 VDK73290.1 - 0.0029 16.9 5.5 0.006 15.8 5.5 1.5 1 0 0 1 1 1 1 Ion transport protein TrkA_C PF02080.21 VDK73290.1 - 0.052 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 TrkA-C domain AAA_33 PF13671.6 VDK73292.1 - 9.7e-26 90.6 0.6 8.5e-25 87.6 0.1 2.5 2 0 0 2 2 2 1 AAA domain SPRY PF00622.28 VDK73292.1 - 2.5e-12 47.0 0.0 6e-12 45.7 0.0 1.7 1 0 0 1 1 1 1 SPRY domain SAP PF02037.27 VDK73292.1 - 1.2e-07 31.3 0.7 3.1e-07 30.0 0.7 1.7 1 0 0 1 1 1 1 SAP domain AAA_17 PF13207.6 VDK73292.1 - 0.0043 17.5 0.0 0.021 15.3 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 VDK73292.1 - 0.0044 17.3 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK73292.1 - 0.011 16.1 0.0 0.037 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 VDK73292.1 - 0.068 12.9 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 VDK73292.1 - 0.086 12.9 0.2 0.49 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 VDK73292.1 - 0.091 12.3 0.0 0.091 12.3 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region SRP54 PF00448.22 VDK73292.1 - 0.097 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RPN1_RPN2_N PF17781.1 VDK73293.1 - 1.9e-113 379.0 0.3 3.8e-113 378.0 0.3 1.5 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 VDK73293.1 - 7.8e-29 99.5 0.1 1.5e-28 98.6 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 VDK73293.1 - 1.3e-11 44.3 19.8 6.5e-05 23.2 0.0 7.7 8 0 0 8 8 8 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 VDK73293.1 - 0.0073 16.7 0.3 1.6 9.2 0.0 3.3 2 1 1 3 3 3 1 HEAT repeats Eapp_C PF10238.9 VDK73293.1 - 0.77 9.8 6.6 3 7.9 0.2 2.7 3 0 0 3 3 3 0 E2F-associated phosphoprotein Sugar_tr PF00083.24 VDK73308.1 - 2.7e-100 336.4 30.8 1.5e-78 264.7 15.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 VDK73308.1 - 7.5e-25 87.6 28.9 3.3e-22 78.9 20.6 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 VDK73308.1 - 7.1e-08 31.3 3.3 7.1e-08 31.3 3.3 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 VDK73308.1 - 1.6e-05 24.0 0.0 0.011 14.7 4.5 2.3 2 1 0 2 2 2 1 MFS_1 like family PSI PF01437.25 VDK73308.1 - 0.056 14.0 6.9 0.12 12.9 6.9 1.5 1 0 0 1 1 1 0 Plexin repeat PSI_integrin PF17205.3 VDK73308.1 - 0.079 12.7 4.5 0.19 11.5 4.5 1.6 1 0 0 1 1 1 0 Integrin plexin domain DUF1912 PF08930.10 VDK73308.1 - 0.11 12.6 0.1 0.26 11.5 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1912) DUF2530 PF10745.9 VDK73308.1 - 0.77 10.0 6.9 1.7 8.9 4.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) DUF389 PF04087.14 VDK73308.1 - 1.2 9.2 12.8 0.081 13.0 5.7 2.7 2 2 1 3 3 3 0 Domain of unknown function (DUF389) V-SNARE_C PF12352.8 VDK73309.1 - 6e-16 58.5 1.0 6e-16 58.5 1.0 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus HCR PF07111.12 VDK73309.1 - 0.069 11.2 0.1 0.09 10.8 0.1 1.1 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) DUF1664 PF07889.12 VDK73309.1 - 0.087 12.9 1.0 2.6 8.1 0.1 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Asp_protease PF09668.10 VDK73310.1 - 2.3e-47 159.9 1.0 3.9e-47 159.1 1.0 1.4 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 VDK73310.1 - 4.4e-17 62.4 0.1 9.1e-17 61.4 0.1 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 VDK73310.1 - 4.3e-09 36.9 0.0 8.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 VDK73310.1 - 2.6e-07 30.5 0.4 6.9e-07 29.1 0.1 1.8 2 0 0 2 2 2 1 Retroviral aspartyl protease UBA PF00627.31 VDK73310.1 - 5.1e-06 26.3 1.6 1e-05 25.3 1.6 1.5 1 0 0 1 1 1 1 UBA/TS-N domain RVP PF00077.20 VDK73310.1 - 2.1e-05 24.7 0.0 4.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.6 VDK73310.1 - 0.11 12.3 0.4 0.33 10.8 0.4 1.7 1 0 0 1 1 1 0 UBA-like domain bZIP_2 PF07716.15 VDK73311.1 - 1.5e-06 28.2 4.8 1.5e-06 28.2 4.8 2.5 2 0 0 2 2 2 1 Basic region leucine zipper YabA PF06156.13 VDK73311.1 - 0.0007 20.2 2.3 0.0007 20.2 2.3 2.3 1 1 1 2 2 2 1 Initiation control protein YabA PKcGMP_CC PF16808.5 VDK73311.1 - 0.0011 18.7 3.8 0.29 11.0 0.5 2.7 2 0 0 2 2 2 2 Coiled-coil N-terminus of cGMP-dependent protein kinase Yuri_gagarin PF15934.5 VDK73311.1 - 0.0049 16.7 5.0 0.011 15.7 5.0 1.6 1 0 0 1 1 1 1 Yuri gagarin BLOC1_2 PF10046.9 VDK73311.1 - 0.0079 16.5 1.2 1.3 9.4 1.1 2.6 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 CC2-LZ PF16516.5 VDK73311.1 - 0.014 15.7 7.5 0.039 14.3 7.5 1.7 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4883 PF16224.5 VDK73311.1 - 0.028 14.7 6.1 1.1 9.5 1.7 2.3 2 0 0 2 2 2 0 DOmain of unknown function (DUF4883) FAM76 PF16046.5 VDK73311.1 - 0.29 10.5 9.7 0.43 9.9 9.7 1.2 1 0 0 1 1 1 0 FAM76 protein DUF724 PF05266.14 VDK73311.1 - 1.6 8.6 10.5 3.7 7.3 10.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 VDK73311.1 - 4.2 7.4 11.6 5.3 7.1 10.2 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 VDK73311.1 - 6.7 6.9 16.2 0.35 11.0 1.2 2.7 1 1 1 2 2 2 0 bZIP transcription factor HA2 PF04408.23 VDK73314.1 - 1.5e-19 70.3 0.1 4.6e-19 68.7 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 VDK73314.1 - 8.4e-09 35.8 0.0 2.7e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 VDK73314.1 - 1.8e-08 34.6 0.0 5.8e-08 33.0 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 VDK73314.1 - 0.074 12.8 0.1 0.23 11.2 0.1 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase UDPGP PF01704.18 VDK73317.1 - 3.7e-153 510.1 0.1 4.3e-153 509.8 0.1 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 VDK73317.1 - 0.045 12.6 0.1 1.5 7.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4301) Smg4_UPF3 PF03467.15 VDK73319.1 - 1e-37 129.8 0.9 1e-37 129.8 0.9 3.5 3 1 0 3 3 3 1 Smg-4/UPF3 family CTP_transf_like PF01467.26 VDK73320.1 - 9.2e-26 90.7 0.0 2.9e-25 89.1 0.0 1.9 2 0 0 2 2 2 1 Cytidylyltransferase-like Ank_5 PF13857.6 VDK73322.1 - 3.5e-105 342.7 24.5 1.4e-12 47.5 0.1 14.6 7 4 7 14 14 14 14 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK73322.1 - 5e-101 331.5 22.2 5.3e-16 59.0 0.0 10.6 5 4 5 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK73322.1 - 1.3e-89 293.5 18.1 4.9e-12 46.1 0.1 12.2 6 4 7 13 13 13 12 Ankyrin repeats (many copies) Ank PF00023.30 VDK73322.1 - 1.3e-85 278.4 33.0 2.3e-07 30.9 0.0 18.0 17 2 1 18 18 18 14 Ankyrin repeat Ank_3 PF13606.6 VDK73322.1 - 3.2e-84 266.7 26.7 1.1e-05 25.4 0.0 19.2 19 0 0 19 19 19 14 Ankyrin repeat PARP PF00644.20 VDK73322.1 - 1.1e-23 83.8 4.1 2.1e-21 76.4 4.1 2.3 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain SAM_1 PF00536.30 VDK73322.1 - 8.6e-08 32.5 0.1 2.6e-07 31.0 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK73322.1 - 8.1e-07 29.1 0.0 2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) UBA PF00627.31 VDK73322.1 - 0.0048 16.8 1.2 0.032 14.2 0.5 2.7 3 0 0 3 3 3 1 UBA/TS-N domain Ras PF00071.22 VDK73323.1 - 2.7e-57 192.9 0.0 3.2e-57 192.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK73323.1 - 3.5e-23 82.1 0.0 6.1e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK73323.1 - 2.2e-10 40.2 0.0 4.1e-10 39.4 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK73323.1 - 0.00042 19.9 0.0 0.00078 19.0 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 VDK73323.1 - 0.018 14.5 0.4 0.062 12.7 0.0 2.0 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 VDK73323.1 - 0.036 13.4 0.0 0.058 12.7 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Glyco_hydro_38N PF01074.22 VDK73324.1 - 2.6e-64 217.4 1.1 4.1e-42 144.5 0.2 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 VDK73324.1 - 8.9e-47 159.9 0.2 1.4e-46 159.2 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 VDK73324.1 - 1.9e-20 72.8 0.0 4.3e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain MARVEL PF01284.23 VDK73326.1 - 0.0012 18.8 17.2 0.002 18.1 17.2 1.3 1 1 0 1 1 1 1 Membrane-associating domain DUF2070 PF09843.9 VDK73326.1 - 0.37 9.0 10.1 0.43 8.8 10.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CobD_Cbib PF03186.13 VDK73326.1 - 6.6 5.8 6.9 5.2 6.2 5.9 1.3 1 1 0 1 1 1 0 CobD/Cbib protein dTDP_sugar_isom PF00908.17 VDK73328.1 - 1.1e-60 204.2 0.0 1.3e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 dTDP-4-dehydrorhamnose 3,5-epimerase zf-RanBP PF00641.18 VDK73329.1 - 3.7e-08 32.5 2.1 8.9e-08 31.3 2.1 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others YAF2_RYBP PF17219.3 VDK73329.1 - 2.5e-07 30.2 0.0 6.2e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Yaf2/RYBP C-terminal binding motif T4SS-DNA_transf PF02534.14 VDK73329.1 - 0.066 12.0 0.4 0.076 11.8 0.4 1.1 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer DUF3456 PF11938.8 VDK73331.1 - 2.2e-28 99.7 3.4 2.2e-28 99.7 3.4 1.7 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP TRM13 PF05206.14 VDK73332.1 - 1.4e-52 178.9 0.5 2.4e-52 178.1 0.5 1.3 1 0 0 1 1 1 1 Methyltransferase TRM13 Med31 PF05669.12 VDK73332.1 - 4.9e-35 119.4 9.2 2.6e-34 117.1 8.9 2.3 2 0 0 2 2 2 1 SOH1 zf-TRM13_CCCH PF11722.8 VDK73332.1 - 7.8e-09 35.1 5.1 7.8e-09 35.1 5.1 3.5 4 0 0 4 4 4 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 VDK73332.1 - 6.4e-07 29.1 1.1 1.5e-06 28.0 1.1 1.7 1 0 0 1 1 1 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.6 VDK73332.1 - 0.0011 18.9 2.0 0.005 16.9 2.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain zf-TRAF PF02176.18 VDK73332.1 - 0.01 16.5 2.8 0.041 14.6 0.2 2.9 2 0 0 2 2 2 0 TRAF-type zinc finger GidB PF02527.15 VDK73332.1 - 0.024 14.0 0.0 0.06 12.7 0.0 1.6 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G EAL PF00563.20 VDK73332.1 - 0.031 13.8 0.0 0.71 9.3 0.0 2.7 3 0 0 3 3 3 0 EAL domain DUF4286 PF14114.6 VDK73332.1 - 0.26 11.8 2.1 0.8 10.2 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4286) Glypican PF01153.19 VDK73333.1 - 4.6e-24 85.2 1.3 2.1e-21 76.4 0.6 2.0 1 1 1 2 2 2 2 Glypican Fz PF01392.22 VDK73333.1 - 0.017 15.8 2.0 0.031 14.9 1.6 1.4 1 1 0 1 1 1 0 Fz domain Glutaredoxin PF00462.24 VDK73348.1 - 5.3e-13 49.0 0.0 8.2e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 VDK73348.1 - 0.018 15.5 0.1 0.029 14.8 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 VDK73348.1 - 0.027 14.5 0.0 0.064 13.3 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin domain Thioredoxin_7 PF13899.6 VDK73348.1 - 0.066 13.4 0.1 0.13 12.5 0.1 1.6 1 1 0 1 1 1 0 Thioredoxin-like Ldl_recept_a PF00057.18 VDK73349.1 - 3.2e-07 30.4 9.7 7e-07 29.4 9.7 1.6 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A MCRS_N PF13325.6 VDK73351.1 - 1.2e-43 149.4 2.4 1.2e-43 149.4 2.4 1.7 2 0 0 2 2 2 1 N-terminal region of micro-spherule protein FHA PF00498.26 VDK73351.1 - 0.0017 18.7 0.0 0.0032 17.8 0.0 1.5 1 0 0 1 1 1 1 FHA domain FHA_2 PF17913.1 VDK73351.1 - 0.12 12.7 0.0 0.32 11.2 0.0 1.7 1 1 0 1 1 1 0 FHA domain RGS_DHEX PF18148.1 VDK73353.1 - 2.8e-45 152.5 1.1 6.8e-45 151.3 1.1 1.7 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 VDK73353.1 - 1.7e-31 108.9 0.3 1.7e-31 108.9 0.3 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain G-gamma PF00631.22 VDK73353.1 - 2.6e-11 43.4 0.2 6.8e-11 42.0 0.2 1.8 1 0 0 1 1 1 1 GGL domain DEP PF00610.21 VDK73353.1 - 1.7e-09 37.6 0.0 1.3e-08 34.7 0.0 2.5 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Neur_chan_memb PF02932.16 VDK73355.1 - 9e-75 251.8 0.4 1.2e-74 251.4 0.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 VDK73355.1 - 7.3e-52 175.9 2.8 6.9e-31 107.4 2.4 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Claudin_2 PF13903.6 VDK73355.1 - 0.073 12.8 2.1 0.13 12.0 1.3 1.8 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF21 PF01595.20 VDK73355.1 - 0.79 9.4 9.4 2.2 8.0 0.4 2.6 1 1 1 2 2 2 0 Cyclin M transmembrane N-terminal domain PET PF06297.14 VDK73360.1 - 1.9e-28 98.6 0.0 3.1e-28 97.9 0.0 1.4 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 VDK73360.1 - 3.3e-10 40.1 4.8 3.3e-10 40.1 4.8 2.7 4 1 0 4 4 4 1 LIM domain LIM PF00412.22 VDK73362.1 - 5.4e-58 193.1 65.2 1.9e-13 50.4 9.7 5.1 5 0 0 5 5 5 5 LIM domain Brix PF04427.18 VDK73364.1 - 1e-37 130.2 3.3 2.9e-37 128.7 0.1 2.6 2 1 0 2 2 2 1 Brix domain PINIT PF14324.6 VDK73366.1 - 5.8e-24 85.1 0.1 5.8e-24 85.1 0.1 2.2 2 0 0 2 2 2 1 PINIT domain Oxidored_q6 PF01058.22 VDK73366.1 - 7.2e-23 80.8 0.1 1.2e-22 80.1 0.1 1.4 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit zf-MIZ PF02891.20 VDK73366.1 - 7e-20 70.5 1.0 1.4e-19 69.5 1.0 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 VDK73366.1 - 8.2e-05 22.4 0.4 0.0002 21.1 0.4 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit MRNIP PF15749.5 VDK73366.1 - 0.0028 18.4 0.0 0.0065 17.2 0.0 1.6 1 0 0 1 1 1 1 MRN-interacting protein SRF-TF PF00319.18 VDK73367.1 - 2.2e-24 84.6 0.5 3.6e-24 84.0 0.5 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CAF1A PF12253.8 VDK73369.1 - 8.8e-24 83.5 6.3 8.8e-24 83.5 6.3 4.7 5 1 0 5 5 5 1 Chromatin assembly factor 1 subunit A DUF4650 PF15509.6 VDK73370.1 - 0.095 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) G-alpha PF00503.20 VDK73371.1 - 1.1e-103 347.1 2.8 1.3e-103 346.9 2.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 VDK73371.1 - 1.1e-15 57.5 1.8 1.4e-12 47.5 0.3 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 VDK73371.1 - 2.4e-05 24.5 1.2 0.016 15.4 0.2 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 VDK73371.1 - 3.5e-05 23.3 1.4 0.0016 17.8 0.1 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 VDK73371.1 - 0.019 14.5 0.0 0.68 9.4 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 VDK73371.1 - 0.053 12.9 0.1 0.092 12.2 0.1 1.3 1 0 0 1 1 1 0 Bacterial TniB protein CTV_P33 PF07184.11 VDK73371.1 - 0.06 12.4 0.6 0.28 10.2 0.0 2.1 2 0 0 2 2 2 0 Citrus tristeza virus P33 protein AAA_29 PF13555.6 VDK73371.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain BAF250_C PF12031.8 VDK73371.1 - 0.12 11.7 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa MIT PF04212.18 VDK73372.1 - 7.9e-25 86.7 4.5 7.9e-25 86.7 4.5 2.1 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain Tae4 PF14113.6 VDK73372.1 - 0.13 12.5 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 SH3_9 PF14604.6 VDK73389.1 - 6.3e-07 29.2 0.4 1.3e-06 28.2 0.4 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK73389.1 - 0.0003 20.4 0.0 0.00052 19.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK73389.1 - 0.017 14.7 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 SH3 domain Peptidase_S9 PF00326.21 VDK73391.1 - 1.9e-45 155.0 0.0 2.8e-45 154.4 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 VDK73391.1 - 1e-13 51.4 0.0 2e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 VDK73391.1 - 9.4e-09 34.9 0.1 0.002 17.4 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 VDK73391.1 - 2.3e-07 30.9 0.0 1.2e-06 28.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 VDK73391.1 - 6.1e-07 28.7 0.0 8.9e-07 28.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_2 PF02230.16 VDK73391.1 - 3.4e-05 23.7 0.0 0.0039 17.0 0.0 2.3 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase DUF2920 PF11144.8 VDK73391.1 - 0.00013 21.3 0.0 0.015 14.5 0.0 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF2920) Peptidase_S15 PF02129.18 VDK73391.1 - 0.00028 20.6 0.0 0.68 9.5 0.0 2.4 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 VDK73391.1 - 0.0043 16.7 0.2 2.3 7.8 0.1 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 VDK73391.1 - 0.0082 15.8 0.0 0.023 14.4 0.0 1.8 2 0 0 2 2 2 1 Serine hydrolase (FSH1) AXE1 PF05448.12 VDK73391.1 - 0.024 13.3 0.0 0.069 11.8 0.0 1.7 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase_phd PF10503.9 VDK73391.1 - 0.038 13.5 0.0 0.085 12.3 0.0 1.6 1 0 0 1 1 1 0 Esterase PHB depolymerase PD40 PF07676.12 VDK73391.1 - 0.049 13.6 0.1 0.14 12.1 0.1 1.8 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat BAAT_C PF08840.11 VDK73391.1 - 0.064 13.2 0.0 1.5 8.7 0.0 2.3 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_4 PF08386.10 VDK73391.1 - 0.2 11.8 0.0 0.45 10.7 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Cpn60_TCP1 PF00118.24 VDK73392.1 - 7.3e-149 496.5 4.8 2.8e-118 395.7 0.7 2.0 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family TraG_N PF07916.11 VDK73392.1 - 0.014 14.2 0.0 0.021 13.7 0.0 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Lipase_2 PF01674.18 VDK73394.1 - 3.1e-68 229.6 0.0 4e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 2) RBFA PF02033.18 VDK73396.1 - 9.3e-06 26.1 0.0 2e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Ribosome-binding factor A CUE PF02845.16 VDK73396.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 CUE domain SNF2_N PF00176.23 VDK73399.1 - 5.4e-52 176.7 1.3 5.4e-52 176.7 1.3 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK73399.1 - 5e-21 75.1 0.1 1.3e-18 67.3 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK73399.1 - 7e-11 42.4 0.0 2.5e-10 40.6 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 VDK73399.1 - 7.6e-07 28.6 0.1 1.8e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase CENP-P PF13096.6 VDK73399.1 - 0.00076 19.2 0.8 0.63 9.7 0.3 2.5 2 0 0 2 2 2 2 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P HHH_3 PF12836.7 VDK73399.1 - 0.0029 17.8 0.0 0.0097 16.1 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif Pkip-1 PF06878.11 VDK73399.1 - 0.23 11.5 0.0 0.23 11.5 0.0 3.5 4 2 1 5 5 5 0 Pkip-1 protein DUF2615 PF11027.8 VDK73400.1 - 3.5e-26 91.4 0.0 3.9e-26 91.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) Helicase_C_2 PF13307.6 VDK73402.1 - 3.8e-49 167.1 0.1 1.2e-48 165.5 0.1 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 VDK73402.1 - 2.3e-43 147.8 0.2 6.3e-43 146.4 0.1 1.9 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 VDK73402.1 - 3.3e-05 23.7 0.0 0.00051 19.9 0.0 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK73402.1 - 0.0002 21.4 0.3 0.011 15.7 0.1 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 VDK73402.1 - 0.073 12.5 0.0 5.2 6.5 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 VDK73402.1 - 0.14 11.2 0.0 0.27 10.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Actin PF00022.19 VDK73403.1 - 3.8e-152 506.6 0.0 1.2e-151 505.0 0.0 1.6 1 1 0 1 1 1 1 Actin Ras PF00071.22 VDK73404.1 - 6.4e-49 165.7 0.1 7.8e-49 165.4 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK73404.1 - 6.9e-29 100.5 0.0 1.2e-28 99.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK73404.1 - 4.6e-13 49.0 0.0 5.7e-13 48.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK73404.1 - 0.00037 20.5 0.6 0.034 14.0 0.1 2.3 1 1 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 VDK73404.1 - 0.00042 20.1 0.0 0.00052 19.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 VDK73404.1 - 0.0011 19.0 0.0 0.002 18.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Hpr_kinase_C PF07475.12 VDK73404.1 - 0.0066 16.0 0.1 0.036 13.6 0.0 1.9 2 0 0 2 2 2 1 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 VDK73404.1 - 0.0071 16.6 0.0 0.012 15.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK73404.1 - 0.019 15.3 0.0 0.019 15.3 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 VDK73404.1 - 0.019 14.8 0.0 0.14 12.1 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_29 PF13555.6 VDK73404.1 - 0.02 14.6 0.6 0.049 13.4 0.4 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_7 PF12775.7 VDK73404.1 - 0.023 14.2 0.0 0.045 13.3 0.0 1.7 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 VDK73404.1 - 0.025 14.6 0.0 0.031 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) MCM PF00493.23 VDK73404.1 - 0.044 12.9 0.0 0.064 12.3 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain Gtr1_RagA PF04670.12 VDK73404.1 - 0.046 13.1 0.1 0.069 12.5 0.1 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 VDK73404.1 - 0.08 13.5 0.3 0.19 12.3 0.2 1.8 1 1 1 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 VDK73404.1 - 0.097 12.4 0.1 0.24 11.1 0.1 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain TniB PF05621.11 VDK73404.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein 7tm_1 PF00001.21 VDK73406.1 - 2e-67 227.3 7.1 3.1e-67 226.7 7.1 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK73406.1 - 1.3e-07 31.3 10.8 0.00017 21.1 6.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx Ctr PF04145.15 VDK73406.1 - 0.04 14.5 1.1 0.13 12.9 0.2 2.2 1 1 1 2 2 2 0 Ctr copper transporter family DUF1129 PF06570.11 VDK73406.1 - 0.12 11.8 2.3 1.9 8.0 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Phage_holin_3_6 PF07332.11 VDK73406.1 - 0.47 10.5 3.8 5.3 7.1 3.4 2.6 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4064 PF13273.6 VDK73406.1 - 4.8 7.5 10.0 0.76 10.1 0.8 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF4064) YwcE PF17368.2 VDK73406.1 - 6.2 7.5 11.1 0.28 11.8 0.8 3.2 3 0 0 3 3 3 0 Spore morphogenesis and germination YwcE Guanylate_kin PF00625.21 VDK73410.1 - 7.2e-41 139.9 0.0 5.3e-37 127.3 0.0 2.3 2 0 0 2 2 2 2 Guanylate kinase PDZ PF00595.24 VDK73410.1 - 3.9e-13 49.6 0.3 7.2e-13 48.7 0.3 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK73410.1 - 5e-13 48.7 0.1 1e-12 47.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK73410.1 - 3.5e-05 24.0 0.1 7.7e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 PDZ domain SH3_1 PF00018.28 VDK73410.1 - 0.0057 16.2 0.0 0.03 13.9 0.0 2.4 1 1 0 1 1 1 1 SH3 domain AHJR-like PF18743.1 VDK73410.1 - 0.04 13.5 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 REase_AHJR-like PikAIV_N PF18605.1 VDK73410.1 - 0.24 11.0 1.5 0.52 9.9 1.5 1.6 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain JAB PF01398.21 VDK73412.1 - 9.9e-25 86.8 0.7 7.9e-24 83.9 0.1 2.6 2 2 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 VDK73412.1 - 4.8e-09 36.6 0.4 9e-09 35.7 0.4 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 VDK73412.1 - 5.7e-07 29.3 0.0 1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Anillin PF08174.11 VDK73413.1 - 5e-25 88.6 0.0 8.4e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Cell division protein anillin Sushi PF00084.20 VDK73431.1 - 5.3e-68 225.5 57.4 8.2e-07 29.5 2.2 13.4 13 0 0 13 13 13 13 Sushi repeat (SCR repeat) Chromadorea_ALT PF05535.12 VDK73432.1 - 3.6e-19 68.7 3.8 6.5e-19 67.9 3.8 1.4 1 0 0 1 1 1 1 Chromadorea ALT protein Beta-Casp PF10996.8 VDK73433.1 - 5.2e-24 84.7 0.0 1e-23 83.7 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 VDK73433.1 - 5.7e-16 58.2 0.0 1.7e-15 56.7 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 VDK73433.1 - 1.2e-14 54.2 0.0 1.7e-08 34.2 0.0 2.7 2 1 1 3 3 3 2 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 VDK73433.1 - 3.8e-11 43.4 1.4 2e-10 41.0 1.4 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 VDK73433.1 - 3e-10 40.0 0.7 4.9e-09 36.0 0.1 2.4 3 0 0 3 3 3 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 VDK73433.1 - 0.0002 21.3 0.0 0.00055 19.9 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF4899 PF16240.5 VDK73433.1 - 0.098 11.8 0.6 0.17 11.0 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4899) Pro_isomerase PF00160.21 VDK73435.1 - 2.9e-36 125.1 0.3 5.2e-36 124.3 0.0 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 VDK73435.1 - 9.7e-14 50.9 0.0 1.8e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK73435.1 - 0.069 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Atg14 PF10186.9 VDK73436.1 - 2e-10 40.3 6.0 3.2e-10 39.6 6.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 EzrA PF06160.12 VDK73436.1 - 0.0025 16.1 3.3 0.0037 15.5 3.3 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Sec8_exocyst PF04048.14 VDK73436.1 - 0.036 14.0 1.2 0.036 14.0 1.2 1.7 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Adaptin_binding PF10199.9 VDK73437.1 - 8.8e-06 26.3 0.2 3.2e-05 24.5 0.2 2.0 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 CAS_C PF12026.8 VDK73439.1 - 5.9e-36 124.5 0.1 1.5e-35 123.2 0.1 1.7 1 0 0 1 1 1 1 Crk-Associated Substrate C-terminal domain Serine_rich PF08824.10 VDK73439.1 - 1.3e-16 61.0 0.6 1.9e-15 57.2 0.1 2.8 2 1 0 2 2 2 1 Serine rich protein interaction domain Peptidase_C1 PF00112.23 VDK73440.1 - 1.7e-58 198.3 1.6 2.5e-58 197.7 1.6 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Beta-lactamase PF00144.24 VDK73440.1 - 1.6e-37 129.5 0.0 2.6e-37 128.8 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase Somatomedin_B PF01033.17 VDK73441.1 - 0.00085 19.7 23.0 0.0069 16.8 21.2 2.1 1 1 1 2 2 2 2 Somatomedin B domain Sterol-sensing PF12349.8 VDK73443.1 - 7.9e-12 45.3 32.4 3.1e-11 43.4 16.1 2.9 2 1 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 VDK73443.1 - 0.00019 19.7 17.5 0.00019 19.7 17.5 2.9 3 0 0 3 3 3 1 Patched family MMPL PF03176.15 VDK73443.1 - 0.00037 19.5 14.4 0.00037 19.5 14.4 3.1 2 1 0 2 2 2 1 MMPL family Sulfate_transp PF00916.20 VDK73467.1 - 3.4e-81 272.9 22.6 4.8e-81 272.4 22.6 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 VDK73467.1 - 2.8e-20 72.1 0.0 4.9e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 STAS domain Bac_export_2 PF01312.19 VDK73467.1 - 4.3 6.5 15.6 0.95 8.6 0.0 3.4 3 1 0 3 3 3 0 FlhB HrpN YscU SpaS Family Methyltransf_21 PF05050.12 VDK73470.1 - 0.081 12.9 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase FkbM domain GSHPx PF00255.19 VDK73471.1 - 1.6e-40 137.1 0.1 2.1e-40 136.7 0.1 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 VDK73471.1 - 1.1e-05 25.4 0.0 3.3e-05 23.8 0.0 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK73471.1 - 7e-05 22.6 0.1 0.00014 21.6 0.1 1.5 1 1 0 1 1 1 1 Redoxin tRNA_int_endo PF01974.17 VDK73472.1 - 6.3e-21 74.2 0.1 2.6e-20 72.2 0.0 2.1 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain DnaB_C PF03796.15 VDK73472.1 - 7.3e-17 61.5 0.2 4.1e-16 59.1 0.0 2.3 2 1 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_25 PF13481.6 VDK73472.1 - 1.5e-14 54.0 0.0 2.9e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 VDK73472.1 - 9.4e-08 31.7 0.0 2.8e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 VDK73472.1 - 4.3e-05 23.8 0.5 0.001 19.4 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 VDK73472.1 - 0.014 15.9 0.5 0.058 13.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 VDK73472.1 - 0.024 14.4 0.0 0.058 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 VDK73472.1 - 0.026 13.6 0.0 0.056 12.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 VDK73472.1 - 0.075 12.8 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 VDK73472.1 - 0.09 12.8 0.0 0.56 10.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain LSM PF01423.22 VDK73473.1 - 1.1e-16 60.3 0.1 1.4e-16 60.0 0.1 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 VDK73473.1 - 0.0029 17.7 0.1 0.0039 17.3 0.1 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain RNB PF00773.19 VDK73474.1 - 7.9e-81 271.9 0.0 2.2e-60 204.7 0.0 2.3 1 1 1 2 2 2 2 RNB domain OB_Dis3 PF17849.1 VDK73474.1 - 1.3e-22 79.6 0.0 3.3e-22 78.3 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 VDK73474.1 - 4.3e-21 75.0 0.0 9.6e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Rrp44_CSD1 PF17216.3 VDK73474.1 - 1.1e-05 25.2 0.0 3.1e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 VDK73474.1 - 0.00059 20.0 0.0 0.64 10.2 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain OB_RNB PF08206.11 VDK73474.1 - 0.04 13.6 0.1 0.086 12.5 0.1 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain RRM_5 PF13893.6 VDK73476.1 - 9.5e-43 144.8 0.2 2.9e-37 127.1 0.0 2.9 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FbpA PF05833.11 VDK73476.1 - 7.1e-35 120.6 5.5 1.3e-34 119.8 5.5 1.4 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 VDK73476.1 - 6.3e-33 113.7 0.0 4.3e-32 111.0 0.0 2.4 2 0 0 2 2 2 1 NFACT protein RNA binding domain RRM_1 PF00076.22 VDK73476.1 - 2.6e-23 81.6 0.0 2.9e-08 33.4 0.0 4.5 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NFACT-C PF11923.8 VDK73476.1 - 8.6e-22 77.1 0.0 8.6e-22 77.1 0.0 2.5 3 0 0 3 3 3 1 NFACT protein C-terminal domain RRM_8 PF11835.8 VDK73476.1 - 3.9e-12 46.2 0.0 8.6e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 RRM-like domain RRM_occluded PF16842.5 VDK73476.1 - 0.00044 20.1 0.0 0.14 12.0 0.0 3.3 3 0 0 3 3 3 1 Occluded RNA-recognition motif DUF4523 PF15023.6 VDK73476.1 - 0.0022 17.9 0.0 0.0068 16.2 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF4523) Dus PF01207.17 VDK73476.1 - 0.021 14.0 0.1 0.021 14.0 0.1 1.8 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) RRM_3 PF08777.11 VDK73476.1 - 4.2 7.5 8.2 6.1 7.0 0.0 4.1 5 0 0 5 5 5 0 RNA binding motif Nas2_N PF18265.1 VDK73478.1 - 7.7e-20 70.6 1.9 6.5e-19 67.6 0.9 2.5 2 1 0 2 2 2 1 Nas2 N_terminal domain PDZ_2 PF13180.6 VDK73478.1 - 1.8e-07 31.4 0.0 4.1e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK73478.1 - 5.6e-07 29.3 0.0 1.1e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 VDK73478.1 - 7.8e-07 29.5 0.0 1.4e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.24 VDK73478.1 - 0.01 16.2 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 0 PDZ domain DUF2170 PF09938.9 VDK73478.1 - 0.086 12.5 0.0 1.2 8.8 0.0 2.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2170) BAF PF02961.14 VDK73479.1 - 1.8e-38 130.8 0.1 2e-38 130.7 0.1 1.0 1 0 0 1 1 1 1 Barrier to autointegration factor PocR PF10114.9 VDK73479.1 - 0.083 12.7 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Sensory domain found in PocR HHH_5 PF14520.6 VDK73479.1 - 0.13 12.9 0.0 0.27 11.9 0.0 1.7 1 1 1 2 2 2 0 Helix-hairpin-helix domain Mito_carr PF00153.27 VDK73480.1 - 1.3e-63 210.9 0.2 1.2e-20 73.2 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 VDK73480.1 - 0.11 11.6 2.6 7.6 5.6 0.0 3.3 3 1 1 4 4 4 0 Gammaproteobacterial serine protease Clathrin PF00637.20 VDK73481.1 - 9e-12 45.1 32.5 0.012 15.4 0.2 10.6 6 2 5 11 11 11 6 Region in Clathrin and VPS ANAPC3 PF12895.7 VDK73481.1 - 9.3e-05 22.6 21.1 0.074 13.3 1.4 8.5 7 4 0 7 7 7 1 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_WDAD PF04053.14 VDK73481.1 - 0.00054 19.1 18.5 0.0013 17.9 1.1 5.6 2 2 3 5 5 5 2 Coatomer WD associated region TPR_1 PF00515.28 VDK73481.1 - 0.0014 18.3 25.7 13 5.8 0.0 11.4 13 1 0 13 13 13 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK73481.1 - 0.0028 17.3 9.0 1.2 8.9 0.0 7.3 7 0 0 7 7 7 1 TPR repeat TPR_2 PF07719.17 VDK73481.1 - 0.013 15.5 51.9 0.77 10.0 0.0 15.8 17 3 2 19 19 18 0 Tetratricopeptide repeat DUF410 PF04190.13 VDK73481.1 - 0.016 15.0 12.3 0.1 12.4 0.8 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF410) PA28_alpha PF02251.18 VDK73481.1 - 0.049 13.7 0.0 0.2 11.7 0.0 2.0 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit Sec16_C PF12931.7 VDK73481.1 - 0.18 11.4 4.8 1.4 8.5 0.1 3.7 3 1 2 5 5 5 0 Sec23-binding domain of Sec16 TPR_7 PF13176.6 VDK73481.1 - 0.69 10.1 26.9 5.2 7.3 0.1 11.2 12 3 1 13 13 12 0 Tetratricopeptide repeat Utp13 PF08625.11 VDK73481.1 - 4.4 7.2 6.3 69 3.3 0.1 5.3 5 2 1 6 6 6 0 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 VDK73482.1 - 3.4e-09 36.9 0.0 0.0072 16.6 0.0 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK73482.1 - 0.00015 22.5 0.1 5 8.2 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Gmad1 PF10647.9 VDK73482.1 - 0.00019 21.3 0.0 0.00024 21.0 0.0 1.1 1 0 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain eIF2A PF08662.11 VDK73482.1 - 0.0029 17.5 0.0 0.0048 16.8 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 VDK73482.1 - 0.016 13.2 0.0 0.017 13.1 0.0 1.1 1 0 0 1 1 1 0 IKI3 family PD40 PF07676.12 VDK73482.1 - 0.036 14.0 0.0 7.2 6.7 0.0 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.7 VDK73482.1 - 0.15 12.0 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Acetyltransf_16 PF05301.11 VDK73483.1 - 3.4e-56 189.8 0.0 4.5e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.7 VDK73483.1 - 0.0011 19.4 0.1 0.0043 17.5 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 VDK73483.1 - 0.0066 16.7 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 VDK73483.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 VDK73483.1 - 0.16 11.9 0.0 0.52 10.3 0.0 1.8 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase GST_N_3 PF13417.6 VDK73485.1 - 2.4e-11 43.9 0.1 4.8e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 VDK73485.1 - 2.4e-10 40.5 0.3 5.2e-10 39.4 0.3 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N_2 PF13409.6 VDK73485.1 - 4.9e-06 26.8 0.1 8.6e-05 22.8 0.0 2.5 1 1 1 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 VDK73485.1 - 4.8e-05 23.5 0.0 0.00012 22.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 VDK73485.1 - 0.0012 19.2 0.0 0.0024 18.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 VDK73485.1 - 0.003 17.6 0.0 0.0089 16.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 VDK73485.1 - 0.0032 17.6 0.0 0.0094 16.1 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 VDK73485.1 - 0.011 16.5 0.1 0.1 13.4 0.0 2.4 1 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain PUF PF00806.19 VDK73488.1 - 3.2e-69 224.9 13.1 1.8e-09 36.8 0.1 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat PLN_propep PF16485.5 VDK73488.1 - 0.0031 17.2 1.7 0.17 11.6 0.4 2.9 1 1 1 2 2 2 1 Protealysin propeptide CPL PF08144.11 VDK73488.1 - 0.0039 17.5 7.6 0.97 9.8 0.2 4.7 2 1 3 5 5 5 1 CPL (NUC119) domain DUF445 PF04286.12 VDK73488.1 - 0.0056 16.5 1.9 0.52 10.0 0.2 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF445) sCache_2 PF17200.4 VDK73488.1 - 0.017 15.0 2.5 0.9 9.4 0.0 4.0 4 1 1 5 5 5 0 Single Cache domain 2 TEX33 PF15400.6 VDK73488.1 - 0.055 14.0 0.5 30 5.1 0.0 3.6 3 2 0 4 4 4 0 Testis-expressed sequence 33 protein family Ku_PK_bind PF08785.11 VDK73488.1 - 0.28 11.3 0.9 2.8 8.1 0.2 2.7 2 1 1 3 3 3 0 Ku C terminal domain like DUF577 PF04510.12 VDK73488.1 - 0.4 10.5 2.0 0.5 10.2 0.3 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF577) RGS PF00615.19 VDK73509.1 - 5.9e-40 136.2 14.4 6.9e-24 84.4 0.8 2.5 3 0 0 3 3 3 2 Regulator of G protein signaling domain DUF1722 PF08349.11 VDK73509.1 - 0.021 15.1 0.7 0.56 10.5 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) Suf PF05843.14 VDK73511.1 - 7.7e-71 239.5 0.0 3.7e-63 214.3 0.0 4.4 3 1 0 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 VDK73511.1 - 0.011 16.5 3.5 19 6.4 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF1910 PF08928.10 VDK73512.1 - 0.1 12.6 0.0 0.71 9.9 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) NDUFA12 PF05071.16 VDK73513.1 - 1.4e-09 38.7 0.1 2e-09 38.2 0.1 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 CAAD PF14159.6 VDK73513.1 - 0.28 11.0 1.9 12 5.8 0.1 2.2 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase ATP12 PF07542.11 VDK73515.1 - 6.5e-28 97.4 0.6 9.5e-28 96.8 0.6 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein PAP2 PF01569.21 VDK73518.1 - 6.3e-27 94.0 2.3 6.3e-27 94.0 2.3 2.1 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 VDK73518.1 - 3.8e-08 33.2 7.3 1.3e-07 31.5 6.3 2.4 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 VDK73518.1 - 0.008 16.7 2.3 0.008 16.7 2.3 3.1 3 2 0 3 3 3 1 PAP2 superfamily C-terminal CRIM PF16978.5 VDK73520.1 - 2.2e-12 47.3 0.0 4.1e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 VDK73520.1 - 0.00014 22.1 0.2 0.00029 21.1 0.2 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology SwrA PF17423.2 VDK73520.1 - 0.054 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 Swarming motility protein Sec62 PF03839.16 VDK73523.1 - 2.4e-71 239.7 0.8 2.4e-71 239.7 0.8 1.7 2 0 0 2 2 2 1 Translocation protein Sec62 Presenilin PF01080.17 VDK73523.1 - 0.00017 20.5 6.5 0.00041 19.2 0.0 2.2 2 0 0 2 2 2 1 Presenilin Strabismus PF06638.11 VDK73523.1 - 0.0059 15.3 0.0 0.011 14.5 0.0 1.4 1 0 0 1 1 1 1 Strabismus protein DEP PF00610.21 VDK73523.1 - 0.008 16.2 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) VIT1 PF01988.19 VDK73523.1 - 0.038 13.9 0.4 0.086 12.7 0.4 1.5 1 1 0 1 1 1 0 VIT family DUF5308 PF17233.2 VDK73523.1 - 0.14 12.4 0.8 0.62 10.3 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5308) CDC45 PF02724.14 VDK73523.1 - 0.59 8.3 32.1 1 7.6 5.0 2.1 2 0 0 2 2 2 0 CDC45-like protein Zip PF02535.22 VDK73523.1 - 0.93 8.6 19.1 0.041 13.1 6.7 2.5 2 1 0 2 2 2 0 ZIP Zinc transporter Gti1_Pac2 PF09729.9 VDK73523.1 - 1.1 9.4 18.3 0.05 13.7 7.4 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family O-antigen_lig PF13425.6 VDK73523.1 - 5.2 5.8 4.7 82 1.8 0.0 2.2 2 0 0 2 2 2 0 O-antigen ligase like membrane protein 4HBT_3 PF13622.6 VDK73524.1 - 3e-21 76.8 0.0 4e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Motile_Sperm PF00635.26 VDK73524.1 - 2.1e-13 50.1 0.0 4.3e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Acyl_CoA_thio PF02551.15 VDK73524.1 - 5.4e-08 32.7 0.0 1.5e-05 24.9 0.1 2.5 2 0 0 2 2 2 2 Acyl-CoA thioesterase Prenyltrans PF00432.21 VDK73525.1 - 2.9e-25 87.7 4.9 1.2e-07 31.3 0.0 5.6 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat PDCD9 PF07147.12 VDK73527.1 - 4.5e-07 29.4 0.1 1e-06 28.3 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S30 (PDCD9) ANAPC4_WD40 PF12894.7 VDK73529.1 - 1.6e-06 28.3 5.2 0.04 14.2 0.1 5.5 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 VDK73529.1 - 0.00043 20.2 32.8 2.6 7.9 0.9 8.2 5 2 4 9 9 9 6 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 VDK73529.1 - 0.001 18.2 23.4 0.0013 17.9 1.4 5.3 6 1 0 7 7 7 2 Coatomer WD associated region PriX PF18689.1 VDK73529.1 - 0.15 12.5 1.1 6.8 7.1 0.1 3.1 2 0 0 2 2 2 0 Primase X DsbG_N PF18257.1 VDK73529.1 - 0.17 12.0 0.5 4.1 7.6 0.2 3.2 3 0 0 3 3 3 0 Disulfide isomerase DsbG N-terminal TPR_7 PF13176.6 VDK73529.1 - 0.46 10.6 11.3 0.98 9.6 0.2 6.3 6 1 0 6 6 6 0 Tetratricopeptide repeat PPR_2 PF13041.6 VDK73529.1 - 2.9 8.2 4.8 20 5.5 0.1 4.2 4 0 0 4 4 4 0 PPR repeat family DUF805 PF05656.14 VDK73531.1 - 0.085 13.3 9.2 0.34 11.4 3.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF805) DUF3995 PF13160.6 VDK73531.1 - 0.15 12.4 2.2 0.21 12.0 0.7 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF3995) PRA1 PF03208.19 VDK73531.1 - 0.28 10.8 12.1 0.29 10.8 5.2 2.5 2 1 0 2 2 2 0 PRA1 family protein ATP-synt PF00231.19 VDK73554.1 - 4e-80 269.5 3.3 4.5e-80 269.3 3.3 1.0 1 0 0 1 1 1 1 ATP synthase Luteo_coat PF00894.18 VDK73554.1 - 0.073 13.0 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Luteovirus coat protein Homeodomain PF00046.29 VDK73555.1 - 3.7e-23 81.1 2.9 8.5e-23 80.0 2.9 1.6 1 0 0 1 1 1 1 Homeodomain Keratin_assoc PF09775.9 VDK73556.1 - 1.3e-39 134.8 10.2 1.4e-39 134.7 10.2 1.0 1 0 0 1 1 1 1 Keratinocyte-associated protein 2 NnrS PF05940.12 VDK73556.1 - 0.027 13.9 9.5 0.033 13.6 9.5 1.1 1 0 0 1 1 1 0 NnrS protein Herpes_LMP1 PF05297.11 VDK73556.1 - 2 7.6 5.7 2.3 7.3 5.7 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) LRR_8 PF13855.6 VDK73557.1 - 3.5e-09 36.3 14.6 1.2e-05 25.0 1.7 2.9 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 VDK73557.1 - 2e-08 34.4 16.5 7.9e-07 29.3 1.5 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK73557.1 - 0.1 13.2 15.8 2.2 9.1 0.2 5.5 5 0 0 5 5 5 0 Leucine Rich Repeat Myosin_tail_1 PF01576.19 VDK73559.1 - 7e-114 381.8 123.1 4.4e-112 375.8 123.1 2.0 1 1 0 1 1 1 1 Myosin tail ADIP PF11559.8 VDK73559.1 - 0.0024 18.0 37.0 0.0048 17.0 14.6 6.8 2 1 4 7 7 7 4 Afadin- and alpha -actinin-Binding HTH_IclR PF09339.10 VDK73559.1 - 0.02 14.7 0.5 0.054 13.3 0.5 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain YabA PF06156.13 VDK73559.1 - 0.021 15.5 1.9 0.021 15.5 1.9 8.0 2 1 5 7 7 7 0 Initiation control protein YabA TPR_19 PF14559.6 VDK73564.1 - 0.0085 16.6 0.1 2.7 8.6 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat LprI PF07007.12 VDK73564.1 - 0.16 12.6 0.2 0.16 12.6 0.2 2.5 3 0 0 3 3 3 0 Lysozyme inhibitor LprI Cdc6_C PF09079.11 VDK73565.1 - 0.082 12.9 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Actin PF00022.19 VDK73571.1 - 4e-46 157.5 0.0 1.8e-43 148.7 0.0 2.7 1 1 0 1 1 1 1 Actin Nucleopor_Nup85 PF07575.13 VDK73573.1 - 2.5e-109 366.4 1.9 3.1e-109 366.1 1.9 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin C2 PF00168.30 VDK73575.1 - 1e-11 45.1 0.0 1.7e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain RBD-FIP PF09457.10 VDK73575.1 - 7e-09 35.5 1.0 1.1e-08 34.8 1.0 1.3 1 0 0 1 1 1 1 FIP domain Zap1_zf2 PF18217.1 VDK73575.1 - 1.2 9.2 3.0 0.75 9.8 0.8 1.9 2 0 0 2 2 2 0 Zap1 zinc finger 2 DNA_topoisoIV PF00521.20 VDK73594.1 - 3.1e-130 434.9 0.1 7.8e-130 433.6 0.1 1.7 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 VDK73594.1 - 5.5e-49 165.7 8.6 3.1e-48 163.3 8.6 2.5 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 VDK73594.1 - 4.3e-26 91.4 1.1 1.2e-25 90.0 1.1 1.8 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 VDK73594.1 - 6.5e-13 49.2 0.0 1.8e-12 47.7 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 VDK73594.1 - 3.8e-07 30.3 0.0 1.4e-06 28.4 0.0 2.1 1 0 0 1 1 1 1 Toprim domain ENT PF03735.14 VDK73594.1 - 0.026 14.6 1.0 0.15 12.2 0.7 2.3 2 0 0 2 2 2 0 ENT domain Viral_DNA_Zn_bi PF03728.13 VDK73595.1 - 0.031 14.8 0.6 0.13 12.8 0.0 2.3 2 0 0 2 2 2 0 Viral DNA-binding protein, zinc binding domain Smg8_Smg9 PF10220.9 VDK73596.1 - 3.7e-161 538.4 6.6 7.3e-160 534.1 6.6 2.3 1 1 0 1 1 1 1 Smg8_Smg9 Ion_trans_2 PF07885.16 VDK73597.1 - 6.1e-24 83.8 28.7 6.6e-15 54.8 6.9 3.9 4 0 0 4 4 4 3 Ion channel fn3 PF00041.21 VDK73597.1 - 5.6e-14 52.2 0.0 3.6e-06 27.2 0.0 2.3 2 0 0 2 2 2 2 Fibronectin type III domain Ion_trans PF00520.31 VDK73597.1 - 2.2e-06 27.1 0.6 2.2e-06 27.1 0.6 2.3 2 0 0 2 2 2 1 Ion transport protein Tissue_fac PF01108.17 VDK73597.1 - 0.01 15.7 2.0 4 7.3 0.0 2.6 1 1 1 2 2 2 0 Tissue factor Lig_chan PF00060.26 VDK73597.1 - 0.016 15.0 0.2 0.016 15.0 0.2 1.9 2 1 1 3 3 3 0 Ligand-gated ion channel DUF3784 PF12650.7 VDK73597.1 - 0.2 11.9 0.1 0.2 11.9 0.1 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF3784) Comm PF15957.5 VDK73597.1 - 0.57 10.5 5.8 2.5 8.4 0.1 3.1 3 0 0 3 3 3 0 Commissureless Insulin_TMD PF17870.1 VDK73597.1 - 0.74 9.9 8.5 35 4.6 0.1 3.5 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment Ank_2 PF12796.7 VDK73598.1 - 2.6e-40 136.9 9.9 8e-19 68.0 0.2 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK73598.1 - 2e-36 123.9 3.7 2.9e-15 56.4 0.0 4.7 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK73598.1 - 3e-29 100.7 11.1 1.5e-11 44.3 0.2 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK73598.1 - 3e-27 91.6 1.6 6.7e-06 26.1 0.0 5.8 5 0 0 5 5 5 5 Ankyrin repeat Ank PF00023.30 VDK73598.1 - 6.7e-27 92.7 9.2 1e-06 28.9 0.0 5.8 5 1 0 5 5 5 4 Ankyrin repeat PRKG1_interact PF15898.5 VDK73598.1 - 4.2e-23 82.2 11.3 4.2e-23 82.2 11.3 4.8 3 2 0 3 3 3 1 cGMP-dependent protein kinase interacting domain Sas10 PF09368.10 VDK73599.1 - 9.5e-22 77.3 9.5 2.1e-21 76.2 9.5 1.6 1 0 0 1 1 1 1 Sas10 C-terminal domain DUF2968 PF11180.8 VDK73599.1 - 0.042 13.5 0.7 0.098 12.3 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Sas10_Utp3 PF04000.15 VDK73599.1 - 0.15 12.7 1.8 0.44 11.2 0.2 2.5 2 0 0 2 2 2 0 Sas10/Utp3/C1D family SAPS PF04499.15 VDK73600.1 - 7.2e-22 77.8 2.6 4.1e-20 72.0 0.5 3.0 3 0 0 3 3 3 2 SIT4 phosphatase-associated protein Gtr1_RagA PF04670.12 VDK73601.1 - 2.9e-96 321.3 0.7 2e-94 315.3 0.4 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ima1_N PF09779.9 VDK73601.1 - 1.7e-28 100.2 8.7 3.9e-28 99.0 8.7 1.7 1 0 0 1 1 1 1 Ima1 N-terminal domain Arf PF00025.21 VDK73601.1 - 4e-08 32.9 0.0 1.1e-07 31.5 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK73601.1 - 5.1e-07 29.9 0.0 1.3e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK73601.1 - 9e-07 28.6 0.0 1.9e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 VDK73601.1 - 9.5e-05 22.5 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 VDK73601.1 - 0.012 14.8 1.5 3.3 6.8 0.5 2.5 1 1 1 2 2 2 0 G-protein alpha subunit DUF815 PF05673.13 VDK73601.1 - 0.041 13.1 0.2 0.34 10.0 0.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 VDK73601.1 - 0.054 13.4 0.1 2.9 7.8 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase CtIP_N PF10482.9 VDK73601.1 - 0.063 13.3 0.5 0.14 12.2 0.5 1.6 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain ABC_tran PF00005.27 VDK73601.1 - 0.14 12.7 0.0 0.39 11.2 0.0 1.7 1 0 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 VDK73601.1 - 0.18 11.6 0.0 0.63 9.8 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation zf-ribbon_3 PF13248.6 VDK73601.1 - 0.21 11.0 2.2 18 4.9 0.3 3.0 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 VDK73601.1 - 7.7 6.6 6.6 1.9 8.5 0.1 2.9 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ins_beta PF03488.14 VDK73602.1 - 0.02 14.9 0.6 0.041 13.9 0.6 1.5 1 0 0 1 1 1 0 Nematode insulin-related peptide beta type Insulin PF00049.18 VDK73602.1 - 0.14 13.2 0.8 0.23 12.5 0.2 1.7 2 0 0 2 2 2 0 Insulin/IGF/Relaxin family Neur_chan_LBD PF02931.23 VDK73616.1 - 3e-13 49.7 2.6 5.9e-13 48.8 2.6 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2070 PF09843.9 VDK73616.1 - 2.7 6.2 9.7 3.5 5.8 9.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Zona_pellucida PF00100.23 VDK73620.1 - 1.6e-09 37.9 3.9 2e-09 37.6 3.9 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain Ribosomal_L13 PF00572.18 VDK73622.1 - 0.02 15.1 0.1 0.057 13.7 0.1 1.8 1 0 0 1 1 1 0 Ribosomal protein L13 vMSA PF00695.19 VDK73623.1 - 0.065 12.3 0.0 0.066 12.3 0.0 1.1 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus CcmD PF04995.14 VDK73623.1 - 0.08 13.0 3.2 0.11 12.6 3.2 1.2 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) PsbX PF06596.11 VDK73623.1 - 6.9 6.8 7.9 1.8 8.6 1.6 2.5 3 0 0 3 3 3 0 Photosystem II reaction centre X protein (PsbX) MLANA PF14991.6 VDK73625.1 - 0.00036 20.8 0.4 0.00056 20.2 0.4 1.3 1 0 0 1 1 1 1 Protein melan-A Comm PF15957.5 VDK73625.1 - 0.015 15.7 0.0 0.023 15.0 0.0 1.4 1 1 0 1 1 1 0 Commissureless TMEM208_SND2 PF05620.11 VDK73625.1 - 0.021 14.6 1.1 0.021 14.6 1.1 2.0 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Shisa PF13908.6 VDK73625.1 - 0.025 14.8 1.9 0.027 14.7 1.3 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator CLN3 PF02487.17 VDK73625.1 - 0.032 13.3 0.3 0.034 13.2 0.3 1.2 1 0 0 1 1 1 0 CLN3 protein U1snRNP70_N PF12220.8 VDK73625.1 - 0.29 11.8 8.7 2.4 8.9 0.4 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Presenilin PF01080.17 VDK73625.1 - 0.84 8.3 5.3 1 8.1 5.3 1.2 1 0 0 1 1 1 0 Presenilin Ets PF00178.22 VDK73626.1 - 3.2e-35 120.4 0.9 6.1e-35 119.5 0.4 1.8 2 0 0 2 2 2 1 Ets-domain DUF829 PF05705.14 VDK73627.1 - 2.4e-44 152.0 3.2 2.8e-44 151.8 3.2 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Jun PF03957.13 VDK73628.1 - 4.9e-07 29.9 12.6 8.4e-07 29.1 11.9 1.8 1 1 0 1 1 1 1 Jun-like transcription factor bZIP_1 PF00170.21 VDK73628.1 - 4.5e-06 26.7 19.7 8.1e-06 25.8 19.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 VDK73628.1 - 4.2e-05 24.0 11.4 8.9e-05 22.9 11.4 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 VDK73628.1 - 9.7e-05 22.4 17.1 0.0009 19.3 17.1 2.2 1 1 0 1 1 1 1 Basic region leucine zipper DotD PF16816.5 VDK73628.1 - 0.11 12.4 0.1 0.31 11.0 0.1 1.7 1 0 0 1 1 1 0 DotD protein FapA PF03961.13 VDK73628.1 - 0.58 8.7 6.2 0.8 8.2 6.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF724 PF05266.14 VDK73628.1 - 1.2 9.0 7.9 1 9.1 6.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4140 PF13600.6 VDK73628.1 - 4.5 7.8 6.9 4.7 7.7 0.4 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) TFIIA PF03153.13 VDK73628.1 - 9 6.2 9.5 15 5.4 9.5 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Kazal_2 PF07648.15 VDK73629.1 - 1.3e-46 156.4 121.4 3.8e-09 36.5 7.8 10.9 10 1 0 10 10 10 8 Kazal-type serine protease inhibitor domain Laminin_G_1 PF00054.23 VDK73629.1 - 1e-21 77.5 0.6 2.7e-07 30.9 0.0 5.1 5 0 0 5 5 5 4 Laminin G domain Laminin_G_2 PF02210.24 VDK73629.1 - 3.1e-21 76.3 0.9 5.5e-07 30.2 0.0 3.7 3 1 0 3 3 3 3 Laminin G domain Kazal_1 PF00050.21 VDK73629.1 - 3.6e-20 71.7 117.1 3.6e-07 30.1 8.5 9.9 10 0 0 10 10 10 8 Kazal-type serine protease inhibitor domain Laminin_EGF PF00053.24 VDK73629.1 - 2.2e-12 46.9 27.9 5.7e-10 39.2 8.5 11.0 9 3 3 12 12 12 2 Laminin EGF domain EGF PF00008.27 VDK73629.1 - 0.0021 18.3 9.1 0.0021 18.3 9.1 13.3 14 0 0 14 14 14 1 EGF-like domain EF-hand_7 PF13499.6 VDK73630.1 - 2.5e-28 98.3 11.3 2e-16 60.2 3.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK73630.1 - 1.5e-27 93.1 15.3 1.6e-08 33.5 2.4 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 VDK73630.1 - 4.1e-25 85.5 12.5 8.1e-07 28.5 0.1 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 VDK73630.1 - 1.1e-18 66.8 13.0 4.8e-10 39.1 3.5 3.5 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 VDK73630.1 - 3.2e-18 65.8 0.1 2.1e-08 34.4 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 VDK73630.1 - 1.2e-11 43.5 18.1 4.1e-05 22.9 0.3 5.4 3 1 2 5 5 5 2 EF hand EF-hand_4 PF12763.7 VDK73630.1 - 1.6e-06 28.0 3.8 0.0021 18.0 0.1 2.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand PHB_acc_N PF07879.11 VDK73630.1 - 0.028 14.5 0.0 1.2 9.2 0.0 3.1 2 1 0 3 3 3 0 PHB/PHA accumulation regulator DNA-binding domain GPHH PF16905.5 VDK73630.1 - 0.1 12.4 0.0 26 4.7 0.0 3.3 4 0 0 4 4 4 0 Voltage-dependent L-type calcium channel, IQ-associated Tropomodulin PF03250.14 VDK73630.1 - 0.45 10.6 3.8 3.3 7.8 0.1 2.8 2 1 1 3 3 3 0 Tropomodulin Ribosomal_S16 PF00886.19 VDK73631.1 - 3.2e-13 49.5 0.0 8.2e-13 48.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S16 SEFIR PF08357.11 VDK73632.1 - 2.1e-17 63.8 0.1 4.1e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 SEFIR domain zf-C2H2 PF00096.26 VDK73634.1 - 4.5e-14 52.0 53.9 0.00079 19.8 1.3 7.9 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK73634.1 - 1.1e-12 47.7 50.3 0.011 16.5 1.3 8.0 8 0 0 8 8 8 5 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK73634.1 - 0.00087 19.6 39.7 0.11 13.0 0.1 8.1 8 0 0 8 8 8 3 Zinc-finger double domain zf-met PF12874.7 VDK73634.1 - 0.0079 16.6 0.1 0.0079 16.6 0.1 5.2 8 0 0 8 8 7 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 VDK73634.1 - 0.012 15.6 0.3 0.012 15.6 0.3 5.6 6 0 0 6 6 6 0 C2H2-type zinc finger zf-Di19 PF05605.12 VDK73634.1 - 0.1 12.9 24.7 0.29 11.4 4.1 4.7 3 2 1 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 VDK73634.1 - 0.12 12.6 0.0 0.12 12.6 0.0 5.7 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding Ribosomal_L33 PF00471.20 VDK73634.1 - 0.62 10.6 8.5 11 6.5 2.7 3.1 2 1 0 2 2 2 0 Ribosomal protein L33 zf-C2H2_2 PF12756.7 VDK73634.1 - 2 8.8 29.9 19 5.7 0.0 5.4 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) DUF2256 PF10013.9 VDK73634.1 - 2.6 8.2 8.0 13 6.0 0.1 4.1 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) zf_C2H2_10 PF18414.1 VDK73634.1 - 3.3 7.3 6.2 2.1 7.9 0.1 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger SIL1 PF16782.5 VDK73638.1 - 6e-08 32.2 3.5 6e-08 32.2 3.5 1.9 2 0 0 2 2 2 1 Nucleotide exchange factor SIL1 Arm PF00514.23 VDK73638.1 - 0.0056 16.7 0.7 4.4 7.5 0.0 3.1 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat RIH_assoc PF08454.11 VDK73638.1 - 0.011 15.6 2.0 0.58 10.0 0.4 2.6 2 0 0 2 2 2 0 RyR and IP3R Homology associated Fes1 PF08609.10 VDK73638.1 - 0.013 16.4 0.4 0.065 14.1 0.1 2.1 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 Atx10homo_assoc PF09759.9 VDK73638.1 - 0.064 13.3 0.6 0.3 11.1 0.0 2.4 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Orthopox_F14 PF06076.12 VDK73638.1 - 0.073 13.4 1.8 0.32 11.3 0.3 2.5 2 0 0 2 2 2 0 Orthopoxvirus F14 protein HEAT_EZ PF13513.6 VDK73638.1 - 0.16 12.5 0.2 2.7 8.6 0.0 2.6 2 0 0 2 2 2 0 HEAT-like repeat FPL PF09758.9 VDK73638.1 - 0.16 12.0 4.5 0.082 12.9 1.9 1.9 2 0 0 2 2 2 0 Uncharacterised conserved protein PhaP_Bmeg PF09602.10 VDK73638.1 - 1 9.3 5.7 1.3 8.9 0.1 2.6 3 0 0 3 3 3 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) WD40 PF00400.32 VDK73639.1 - 2.8e-27 94.4 0.1 0.00032 21.4 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat CSTF1_dimer PF16699.5 VDK73639.1 - 4.5e-23 80.8 0.1 8.1e-23 79.9 0.1 1.4 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain ANAPC4_WD40 PF12894.7 VDK73639.1 - 1.6e-14 54.0 0.0 0.0038 17.5 0.0 4.9 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK73639.1 - 6.2e-07 29.5 0.0 0.005 16.7 0.0 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 VDK73639.1 - 1.1e-06 27.9 0.1 0.01 14.8 0.0 2.4 1 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 VDK73639.1 - 0.013 13.9 0.1 0.043 12.1 0.0 1.8 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 VDK73639.1 - 0.083 11.4 0.0 0.18 10.3 0.0 1.6 1 0 0 1 1 1 0 Cytochrome D1 heme domain Nup160 PF11715.8 VDK73639.1 - 0.14 10.7 0.3 21 3.6 0.0 2.8 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DUF4718 PF15842.5 VDK73657.1 - 0.02 14.7 0.8 0.024 14.4 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) ATP_bind_1 PF03029.17 VDK73660.1 - 1.5e-86 290.1 0.3 1.7e-86 289.9 0.3 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 VDK73660.1 - 0.00029 20.7 0.0 0.00082 19.2 0.0 2.0 1 1 1 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_18 PF13238.6 VDK73660.1 - 0.0032 18.0 0.1 0.0098 16.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK73660.1 - 0.0077 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK73660.1 - 0.024 15.0 0.0 0.22 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 VDK73660.1 - 0.03 14.8 0.0 0.066 13.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 VDK73660.1 - 0.038 14.1 0.0 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 VDK73660.1 - 0.043 13.5 0.0 0.41 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 VDK73660.1 - 0.065 12.6 0.0 1 8.6 0.0 2.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 VDK73660.1 - 0.085 12.6 0.0 0.29 10.9 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 VDK73660.1 - 0.1 12.9 0.5 0.37 11.1 0.0 2.1 2 2 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 VDK73660.1 - 0.1 12.5 0.0 3.4 7.5 0.0 2.4 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 VDK73660.1 - 0.12 12.8 0.4 0.41 11.1 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 VDK73660.1 - 0.15 11.6 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region IML1 PF12257.8 VDK73662.1 - 1.2e-84 283.9 6.8 2.3e-83 279.6 6.8 2.2 1 1 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 VDK73662.1 - 0.0015 18.5 0.0 0.0049 16.9 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SF3b1 PF08920.10 VDK73664.1 - 2.6e-43 147.3 30.8 2.4e-39 134.5 7.8 5.1 2 2 0 2 2 2 1 Splicing factor 3B subunit 1 HEAT_EZ PF13513.6 VDK73664.1 - 5.5e-09 36.4 3.0 0.33 11.5 0.0 6.9 7 0 0 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 VDK73664.1 - 6.1e-09 36.2 3.8 0.011 16.1 0.0 6.5 5 2 2 7 7 6 3 HEAT repeats HEAT PF02985.22 VDK73664.1 - 1.7e-08 34.0 10.2 1.3 9.5 0.1 8.5 9 0 0 9 9 9 3 HEAT repeat Cnd1 PF12717.7 VDK73664.1 - 0.00026 21.1 10.6 2.4 8.2 0.0 5.7 6 1 1 7 7 6 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 VDK73664.1 - 0.00036 21.1 2.0 4.1 8.1 0.0 5.2 4 1 0 5 5 5 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 VDK73664.1 - 0.00088 18.9 0.3 1 8.8 0.0 3.2 3 0 0 3 3 3 2 CLASP N terminal Adaptin_N PF01602.20 VDK73664.1 - 0.0011 17.7 0.8 0.029 12.9 0.0 2.7 1 1 1 2 2 2 2 Adaptin N terminal region MMS19_C PF12460.8 VDK73664.1 - 0.0046 16.1 0.0 22 4.0 0.0 4.0 3 1 0 3 3 3 0 RNAPII transcription regulator C-terminal UNC45-central PF11701.8 VDK73664.1 - 0.0054 16.7 0.1 0.017 15.1 0.1 1.8 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central NUC173 PF08161.12 VDK73664.1 - 0.041 13.5 0.3 3.7 7.1 0.0 3.8 5 1 0 5 5 5 0 NUC173 domain TIP120 PF08623.10 VDK73664.1 - 0.071 12.9 1.3 1.3 8.8 0.0 2.9 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) DNA_pol_phi PF04931.13 VDK73664.1 - 0.17 9.9 0.1 4.4 5.3 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase phi DUF3730 PF12530.8 VDK73664.1 - 0.19 11.3 0.2 0.57 9.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3730) EBP50_C PF09007.11 VDK73665.1 - 6.4 7.8 8.2 0.21 12.6 0.7 2.3 3 0 0 3 3 3 0 EBP50, C-terminal Orf78 PF06024.12 VDK73666.1 - 0.0041 17.4 0.3 0.0068 16.7 0.3 1.3 1 0 0 1 1 1 1 Orf78 (ac78) ASFV_J13L PF05568.11 VDK73666.1 - 0.026 14.3 0.5 0.038 13.7 0.5 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein HemY_N PF07219.13 VDK73666.1 - 0.2 11.9 0.1 0.28 11.4 0.1 1.2 1 0 0 1 1 1 0 HemY protein N-terminus Pkinase_Tyr PF07714.17 VDK73668.1 - 1.7e-37 129.1 0.1 2.6e-37 128.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK73668.1 - 6.7e-26 91.2 0.1 1.1e-25 90.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 VDK73668.1 - 0.0022 17.4 0.1 0.0035 16.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4890 PF16231.5 VDK73672.1 - 0.051 14.1 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4890) Oxysterol_BP PF01237.18 VDK73674.1 - 9e-70 235.4 4.8 9e-70 235.4 4.8 2.8 2 1 0 2 2 2 1 Oxysterol-binding protein FAM76 PF16046.5 VDK73674.1 - 6.1 6.1 24.8 5.4e+02 -0.3 24.8 2.4 1 1 0 1 1 1 0 FAM76 protein BCAS3 PF12490.8 VDK73675.1 - 2.3e-12 47.0 0.3 6.3e-05 22.6 0.0 2.3 1 1 1 2 2 2 2 Breast carcinoma amplified sequence 3 LRR_8 PF13855.6 VDK73708.1 - 1.9e-14 53.2 5.4 1.9e-06 27.5 0.4 2.9 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 VDK73708.1 - 2.2e-09 37.4 9.7 0.00013 22.3 0.8 4.0 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK73708.1 - 5.5e-06 26.2 7.6 6.8 7.7 0.0 5.6 4 1 1 5 5 5 2 Leucine Rich Repeat LRR_9 PF14580.6 VDK73708.1 - 0.013 15.0 0.6 0.051 13.1 0.5 1.9 1 1 1 2 2 2 0 Leucine-rich repeat LRRCT PF01463.24 VDK73708.1 - 0.061 13.9 0.0 0.32 11.6 0.0 2.3 2 0 0 2 2 2 0 Leucine rich repeat C-terminal domain LRR_6 PF13516.6 VDK73708.1 - 0.071 13.2 11.7 4.2 7.7 0.1 4.8 5 0 0 5 5 5 0 Leucine Rich repeat BatD PF13584.6 VDK73708.1 - 0.14 10.9 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance LVIVD PF08309.11 VDK73708.1 - 0.75 9.2 2.4 12 5.4 0.2 2.6 2 0 0 2 2 2 0 LVIVD repeat ERM PF00769.19 VDK73709.1 - 1.6e-53 182.1 59.4 1.6e-53 182.1 59.4 2.2 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FERM_M PF00373.18 VDK73709.1 - 7.6e-28 97.3 0.1 7.6e-28 97.3 0.1 3.1 3 1 0 3 3 3 1 FERM central domain FERM_C PF09380.10 VDK73709.1 - 1.1e-27 96.2 0.1 6.7e-27 93.7 0.0 2.4 1 1 1 2 2 2 1 FERM C-terminal PH-like domain FERM_N PF09379.10 VDK73709.1 - 7.5e-14 51.4 0.1 2.7e-13 49.7 0.1 2.0 1 0 0 1 1 1 1 FERM N-terminal domain ACBP PF00887.19 VDK73709.1 - 0.0027 17.9 0.1 0.0027 17.9 0.1 3.0 3 0 0 3 3 3 1 Acyl CoA binding protein NPV_P10 PF05531.12 VDK73709.1 - 0.19 12.2 13.7 4 8.0 1.2 3.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Ribosomal_S15 PF00312.22 VDK73710.1 - 5.5e-10 39.3 0.2 1.1e-09 38.3 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S15 FTCD_C PF04961.12 VDK73710.1 - 0.081 12.7 0.2 0.17 11.7 0.2 1.6 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DUF3718 PF12514.8 VDK73710.1 - 0.088 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3718) Seryl_tRNA_N PF02403.22 VDK73710.1 - 0.33 11.2 6.8 0.8 10.0 6.8 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF29 PF01724.16 VDK73710.1 - 0.67 10.2 5.9 6.3 7.0 2.4 3.2 2 2 1 3 3 3 0 Domain of unknown function DUF29 FapA PF03961.13 VDK73710.1 - 2.5 6.6 9.7 7.3 5.1 8.4 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A Patched PF02460.18 VDK73711.1 - 5.1e-260 865.0 11.2 5.9e-260 864.8 11.2 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK73711.1 - 5.5e-43 146.5 5.4 5.5e-43 146.5 5.4 2.9 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK73711.1 - 3.8e-05 22.8 4.8 3.8e-05 22.8 4.8 2.3 2 0 0 2 2 2 1 MMPL family ACR_tran PF00873.19 VDK73711.1 - 0.23 9.1 16.9 0.43 8.2 16.9 1.4 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family TMCO5 PF14992.6 VDK73711.1 - 1.5 8.3 3.1 0.75 9.3 0.3 1.8 2 0 0 2 2 2 0 TMCO5 family MAD PF05557.13 VDK73713.1 - 1.1e-17 63.7 16.0 1.1e-17 63.7 16.0 3.1 2 1 1 3 3 3 2 Mitotic checkpoint protein DUF501 PF04417.12 VDK73713.1 - 0.032 14.0 0.7 0.032 14.0 0.7 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF501) DUF1664 PF07889.12 VDK73713.1 - 2.6 8.1 18.4 2.7 8.0 2.3 3.9 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) MORN PF02493.20 VDK73714.1 - 2.4e-31 105.7 72.5 3.7e-05 23.4 1.2 9.0 9 0 0 9 9 9 8 MORN repeat BIR PF00653.21 VDK73715.1 - 9.3e-20 71.1 5.4 2.4e-19 69.7 5.4 1.8 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain UQ_con PF00179.26 VDK73717.1 - 9.2e-30 103.1 0.1 1e-28 99.7 0.0 2.6 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme UEV PF05743.13 VDK73717.1 - 0.00054 19.8 0.1 0.0015 18.4 0.1 1.8 1 0 0 1 1 1 1 UEV domain XRN_M PF17846.1 VDK73719.1 - 4.1e-160 533.5 1.5 7.3e-160 532.7 1.4 1.4 2 0 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 VDK73719.1 - 1.2e-102 342.4 0.0 3.1e-102 341.1 0.0 1.7 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus CLIP1_ZNF PF16641.5 VDK73719.1 - 0.014 15.3 2.7 0.029 14.2 2.7 1.6 1 0 0 1 1 1 0 CLIP1 zinc knuckle DEAD_2 PF06733.15 VDK73728.1 - 5.9e-16 58.6 0.1 9e-16 58.0 0.1 1.2 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 VDK73728.1 - 0.011 15.8 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DEAD PF00270.29 VDK73728.1 - 0.028 14.2 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_11 PF13086.6 VDK73728.1 - 0.059 13.2 0.0 0.076 12.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain Serine_rich PF08824.10 VDK73728.1 - 0.14 12.1 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Serine rich protein interaction domain WH2 PF02205.20 VDK73729.1 - 2.3e-08 33.6 0.3 5e-08 32.5 0.3 1.6 1 0 0 1 1 1 1 WH2 motif CAP_N PF01213.19 VDK73729.1 - 0.0012 18.4 1.3 0.0012 18.4 1.3 4.0 3 2 1 5 5 5 1 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 VDK73729.1 - 0.011 15.7 5.5 0.011 15.7 5.5 4.3 4 0 0 4 4 4 0 Proline-rich membrane anchor 1 MRP-S26 PF14943.6 VDK73731.1 - 1.6e-49 168.1 15.8 2e-49 167.8 15.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 AAA_23 PF13476.6 VDK73731.1 - 0.0019 18.7 4.4 0.0024 18.4 4.4 1.1 1 0 0 1 1 1 1 AAA domain Mit_ribos_Mrp51 PF11709.8 VDK73731.1 - 0.42 10.1 5.7 0.54 9.8 5.7 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit Prominin PF05478.11 VDK73731.1 - 1.1 7.1 4.7 1.4 6.8 4.7 1.1 1 0 0 1 1 1 0 Prominin Mitofilin PF09731.9 VDK73731.1 - 2.1 7.1 20.4 2.9 6.6 20.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF883 PF05957.13 VDK73731.1 - 4.5 7.9 6.3 9.1 7.0 6.3 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Med11 PF10280.9 VDK73732.1 - 3.4e-10 40.5 1.2 5.3e-10 39.9 1.2 1.3 1 0 0 1 1 1 1 Mediator complex protein UPF0242 PF06785.11 VDK73732.1 - 0.0093 16.1 2.6 0.063 13.4 1.6 2.0 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus DHR10 PF18595.1 VDK73732.1 - 0.032 14.3 1.8 0.032 14.3 1.8 2.5 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain Cob_adeno_trans PF01923.18 VDK73732.1 - 0.085 13.0 0.6 0.14 12.2 0.5 1.5 1 1 0 1 1 1 0 Cobalamin adenosyltransferase Cluap1 PF10234.9 VDK73732.1 - 0.12 11.8 4.8 0.18 11.1 3.0 1.8 1 1 1 2 2 2 0 Clusterin-associated protein-1 KxDL PF10241.9 VDK73732.1 - 0.2 12.0 3.0 1.5 9.1 0.0 2.8 2 1 1 3 3 3 0 Uncharacterized conserved protein Acyl_transf_3 PF01757.22 VDK73733.1 - 1.4e-13 50.7 36.3 2e-13 50.2 36.3 1.1 1 0 0 1 1 1 1 Acyltransferase family TPR_1 PF00515.28 VDK73739.1 - 1.8e-05 24.3 0.4 1.8e-05 24.3 0.4 3.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK73739.1 - 8.6e-05 22.1 3.5 0.011 15.4 0.2 2.7 1 1 1 2 2 2 2 TPR repeat TPR_6 PF13174.6 VDK73739.1 - 0.0012 19.4 0.1 3.2 8.6 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK73739.1 - 0.0023 18.4 0.5 0.006 17.1 0.5 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK73739.1 - 0.0023 17.9 0.3 0.0023 17.9 0.3 4.2 6 0 0 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 VDK73739.1 - 0.0091 16.0 0.2 0.03 14.4 0.2 1.9 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 VDK73739.1 - 0.015 15.3 0.3 0.07 13.2 0.1 2.3 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 VDK73739.1 - 0.029 14.5 0.0 0.15 12.2 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 VDK73739.1 - 0.035 14.4 1.5 0.27 11.6 0.2 2.8 3 1 1 4 4 4 0 Tetratricopeptide repeat SQHop_cyclase_N PF13249.6 VDK73739.1 - 0.037 13.1 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Squalene-hopene cyclase N-terminal domain TPR_17 PF13431.6 VDK73739.1 - 0.11 12.9 0.0 0.56 10.7 0.0 2.3 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK73739.1 - 0.15 12.9 0.6 1.8 9.6 0.1 2.9 2 2 1 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK73739.1 - 1.7 9.1 6.8 7.5 7.0 0.2 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 VDK73741.1 - 2.3e-12 46.0 3.1 0.0025 17.8 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 VDK73741.1 - 2.7e-11 42.8 0.5 0.002 17.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK73741.1 - 4.5e-09 35.8 1.2 3e-06 26.8 0.0 3.7 3 1 1 4 4 4 1 TPR repeat TPR_8 PF13181.6 VDK73741.1 - 3.8e-08 32.9 1.3 0.017 15.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK73741.1 - 1.1e-06 29.1 3.3 0.002 18.6 0.0 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK73741.1 - 2.6e-06 27.4 0.5 0.00015 21.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK73741.1 - 3.8e-06 27.5 1.7 0.00031 21.3 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK73741.1 - 5.8e-05 23.6 7.0 0.0043 17.7 0.0 3.8 3 1 2 5 5 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK73741.1 - 0.00027 21.1 1.7 0.0028 17.9 0.4 3.0 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 VDK73741.1 - 0.00029 21.1 3.0 0.0047 17.2 0.1 3.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 VDK73741.1 - 0.0092 16.6 2.3 1.8 9.3 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TOM20_plant PF06552.12 VDK73741.1 - 0.027 14.2 1.8 0.4 10.4 1.8 2.5 1 1 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_10 PF13374.6 VDK73741.1 - 0.85 9.6 3.1 12 5.9 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat A_deamin PF02137.18 VDK73744.1 - 9.2e-37 127.2 0.6 2.1e-26 93.2 0.1 2.8 1 1 0 2 2 2 2 Adenosine-deaminase (editase) domain dsrm PF00035.26 VDK73744.1 - 1.8e-22 79.8 3.7 1.2e-06 29.1 0.2 4.7 4 0 0 4 4 4 3 Double-stranded RNA binding motif zf-C2H2 PF00096.26 VDK73746.1 - 4.2e-15 55.3 26.6 9.3e-05 22.7 3.7 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK73746.1 - 1.8e-12 47.1 29.1 4.4e-09 36.3 1.2 5.0 5 1 0 5 5 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK73746.1 - 6.2e-09 35.9 30.1 0.0012 19.5 0.8 5.0 5 0 0 5 5 4 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 VDK73746.1 - 6.3e-05 23.6 16.6 0.066 13.9 1.0 3.5 3 1 1 4 4 4 3 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 VDK73746.1 - 0.00024 20.6 7.4 3 7.5 0.0 4.5 4 0 0 4 4 4 2 Ubiquitin-Binding Zinc Finger zf-H2C2_5 PF13909.6 VDK73746.1 - 0.0092 15.7 3.5 0.0092 15.7 3.5 4.3 6 0 0 6 6 5 2 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 VDK73746.1 - 0.025 14.2 0.2 0.025 14.2 0.2 3.5 1 1 3 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HC_2 PF13913.6 VDK73746.1 - 0.07 13.0 0.1 0.07 13.0 0.1 3.5 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 VDK73746.1 - 0.45 10.3 27.3 0.18 11.6 2.1 5.2 6 0 0 6 6 6 0 zinc-finger C2H2-type zinc_ribbon_15 PF17032.5 VDK73746.1 - 0.67 10.7 10.2 1.7 9.4 0.6 2.5 1 1 0 2 2 2 0 zinc-ribbon family XPA_N PF01286.18 VDK73746.1 - 0.74 9.9 12.9 5.5 7.1 0.1 4.2 4 0 0 4 4 4 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 VDK73746.1 - 0.83 9.8 16.8 5.2 7.3 0.8 4.3 3 1 2 5 5 5 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 VDK73746.1 - 0.84 9.4 0.1 0.84 9.4 0.1 3.4 4 0 0 4 4 4 0 Rubredoxin metal binding domain ADK_lid PF05191.14 VDK73746.1 - 0.9 9.6 9.7 0.43 10.6 3.6 3.1 3 0 0 3 3 3 0 Adenylate kinase, active site lid zf-dskA_traR PF01258.17 VDK73746.1 - 1.3 9.0 5.6 6.2 6.9 0.0 3.1 4 0 0 4 4 4 0 Prokaryotic dksA/traR C4-type zinc finger zf-Di19 PF05605.12 VDK73746.1 - 1.6 9.1 14.3 1.5 9.2 1.8 3.6 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 VDK73746.1 - 2.7 8.5 20.7 0.82 10.2 2.1 4.5 5 0 0 5 5 4 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 VDK73746.1 - 3.7 7.7 28.1 0.15 12.1 3.7 4.1 4 0 0 4 4 3 0 C2H2-type zinc finger C1_1 PF00130.22 VDK73746.1 - 3.8 7.5 12.3 0.44 10.5 0.5 3.3 1 1 2 3 3 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_2 PF12756.7 VDK73746.1 - 3.8 7.9 15.8 15 6.0 0.9 4.0 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-trcl PF13451.6 VDK73746.1 - 6.5 6.7 11.2 22 5.0 0.1 4.0 4 0 0 4 4 4 0 Probable zinc-ribbon domain zf-MYST PF17772.1 VDK73746.1 - 6.6 6.4 10.2 8.4 6.1 0.1 3.9 3 1 1 4 4 4 0 MYST family zinc finger domain zf-Sec23_Sec24 PF04810.15 VDK73746.1 - 6.8 6.8 8.5 73 3.5 0.3 3.8 3 1 0 3 3 3 0 Sec23/Sec24 zinc finger Ank_2 PF12796.7 VDK73747.1 - 3.3e-45 152.6 14.6 7.5e-12 45.7 0.6 6.1 4 2 2 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK73747.1 - 9.2e-34 115.4 14.3 1.7e-08 34.8 0.1 8.1 7 1 1 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK73747.1 - 4.8e-28 94.1 10.3 0.0019 18.6 0.1 11.5 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.6 VDK73747.1 - 5.8e-28 96.6 7.0 2e-08 34.3 0.4 8.2 5 3 3 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 VDK73747.1 - 5.3e-21 74.1 20.3 0.00063 20.1 0.2 11.2 11 0 0 11 11 11 6 Ankyrin repeat Dpy-30 PF05186.13 VDK73747.1 - 7.5e-11 41.6 0.1 2.9e-10 39.7 0.1 2.1 1 0 0 1 1 1 1 Dpy-30 motif Cytochrom_B562 PF07361.11 VDK73747.1 - 2e-06 28.4 0.2 1.6 9.4 0.0 3.8 3 0 0 3 3 3 2 Cytochrome b562 DUF1843 PF08898.10 VDK73747.1 - 0.00015 22.2 2.8 2.9 8.5 0.0 4.2 3 0 0 3 3 3 2 Domain of unknown function (DUF1843) DUF2520 PF10728.9 VDK73747.1 - 0.05 13.4 3.1 11 5.7 0.1 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF2520) DUF5095 PF17016.5 VDK73747.1 - 0.3 10.7 2.5 0.52 10.0 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5095) Ras PF00071.22 VDK73748.1 - 1.7e-52 177.3 0.0 2e-52 177.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK73748.1 - 3.4e-20 72.4 0.0 4.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK73748.1 - 5.1e-10 39.1 0.0 6.7e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK73748.1 - 2.1e-05 24.5 1.8 0.035 14.0 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 VDK73748.1 - 0.0001 21.9 0.2 0.00036 20.1 0.0 1.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDK73748.1 - 0.00023 21.2 0.0 0.00036 20.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 VDK73748.1 - 0.00024 21.0 0.9 0.0023 17.8 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 VDK73748.1 - 0.0012 18.4 0.0 0.0021 17.6 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B G-alpha PF00503.20 VDK73748.1 - 0.0016 17.6 0.0 0.14 11.3 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 VDK73748.1 - 0.02 14.2 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 VDK73748.1 - 0.081 13.3 0.1 0.11 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 VDK73748.1 - 0.15 11.7 0.4 0.77 9.5 0.1 2.0 1 1 0 2 2 2 0 AAA domain ANAPC5 PF12862.7 VDK73749.1 - 4e-10 39.6 12.9 8.4e-10 38.6 0.9 4.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 5 TPR_MalT PF17874.1 VDK73749.1 - 7.7e-07 28.8 6.1 7.7e-07 28.8 6.1 2.5 2 1 0 2 2 2 1 MalT-like TPR region TPR_21 PF09976.9 VDK73749.1 - 0.0015 18.3 0.7 1.4 8.6 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 VDK73749.1 - 0.0016 18.7 2.2 16 5.8 0.1 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK73749.1 - 0.0073 16.3 0.5 9.4 6.6 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat CLTH PF10607.9 VDK73749.1 - 0.083 12.8 1.3 1.4 8.8 1.3 2.7 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain BAR_2 PF10455.9 VDK73749.1 - 0.1 11.7 1.6 4 6.5 0.1 2.6 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking ANAPC3 PF12895.7 VDK73749.1 - 0.1 12.8 3.5 17 5.7 0.7 3.5 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 VDK73749.1 - 0.15 12.9 3.6 34 5.6 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Gelsolin PF00626.22 VDK73750.1 - 2.2e-64 213.3 6.0 5.5e-14 51.8 0.0 6.6 6 1 0 6 6 6 5 Gelsolin repeat LRR_8 PF13855.6 VDK73750.1 - 8.3e-42 140.8 45.1 3e-08 33.3 10.9 7.4 5 2 2 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 VDK73750.1 - 2.2e-28 97.8 51.3 9.8e-05 22.7 1.3 8.5 6 1 3 9 9 9 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK73750.1 - 8e-06 25.7 43.1 7.4 7.6 0.1 12.7 14 0 0 14 14 14 5 Leucine Rich Repeat LRR_5 PF13306.6 VDK73750.1 - 0.16 11.9 0.4 12 5.9 0.1 2.4 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) TAP_C PF03943.13 VDK73751.1 - 3.8e-18 64.8 0.3 6.6e-18 64.1 0.3 1.4 1 0 0 1 1 1 1 TAP C-terminal domain Tap-RNA_bind PF09162.10 VDK73751.1 - 2.3e-10 40.2 0.0 5.4e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Tap, RNA-binding NTF2 PF02136.20 VDK73751.1 - 0.0009 19.8 0.0 0.0028 18.2 0.0 1.9 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.7 VDK73751.1 - 0.0089 16.4 1.1 0.017 15.5 0.1 2.0 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) Phage_holin_2_2 PF10746.9 VDK73751.1 - 0.048 13.3 0.1 0.098 12.3 0.1 1.5 1 0 0 1 1 1 0 Phage holin T7 family, holin superfamily II UPF0183 PF03676.14 VDK73780.1 - 1.4e-129 432.8 0.0 1.6e-129 432.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) Metallophos PF00149.28 VDK73781.1 - 1.6e-21 77.8 0.0 3e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PhoD PF09423.10 VDK73781.1 - 0.089 11.8 0.0 3.1 6.7 0.0 2.1 2 0 0 2 2 2 0 PhoD-like phosphatase DUF116 PF01976.17 VDK73781.1 - 0.13 11.8 0.0 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF116 MARVEL PF01284.23 VDK73782.1 - 8.8e-10 38.8 22.0 1.5e-09 38.0 22.0 1.4 1 1 0 1 1 1 1 Membrane-associating domain Innexin PF00876.18 VDK73783.1 - 1.2e-42 146.5 7.1 4e-42 144.8 7.1 1.7 1 1 0 1 1 1 1 Innexin Pannexin_like PF12534.8 VDK73783.1 - 0.19 10.8 1.9 0.36 9.9 0.2 1.9 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Collagen PF01391.18 VDK73784.1 - 2e-26 91.5 80.2 3.6e-10 39.5 25.7 4.1 2 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK73784.1 - 1.3e-11 44.3 1.9 1.7e-11 44.0 1.9 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain TelA PF05816.11 VDK73784.1 - 0.037 13.1 0.0 0.047 12.8 0.0 1.0 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) zf-Paramyx-P PF13008.7 VDK73784.1 - 0.12 11.8 3.4 0.25 10.8 3.4 1.5 1 0 0 1 1 1 0 Zinc-binding domain of Paramyxoviridae V protein Ufd2P_core PF10408.9 VDK73784.1 - 0.15 10.6 0.0 0.19 10.3 0.0 1.0 1 0 0 1 1 1 0 Ubiquitin elongating factor core DUF4706 PF15797.5 VDK73784.1 - 0.18 12.4 0.0 0.25 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) NRBF2 PF08961.10 VDK73785.1 - 0.04 13.5 5.6 0.072 12.7 5.6 1.5 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Spore_II_R PF09551.10 VDK73785.1 - 0.11 12.9 2.1 0.14 12.6 2.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) XhlA PF10779.9 VDK73785.1 - 0.14 12.4 4.7 0.22 11.8 4.7 1.3 1 0 0 1 1 1 0 Haemolysin XhlA CENP-F_leu_zip PF10473.9 VDK73785.1 - 0.15 12.1 13.8 0.31 11.0 13.8 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 VDK73785.1 - 0.24 11.9 13.3 0.28 11.7 0.8 2.1 1 1 1 2 2 2 0 Cell division protein ZapB YabA PF06156.13 VDK73785.1 - 1.6 9.4 9.9 2.3 8.9 4.5 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Pkinase_Tyr PF07714.17 VDK73786.1 - 8.8e-80 267.7 0.0 1.4e-79 267.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 VDK73786.1 - 3.8e-47 159.0 3.4 1.2e-22 80.1 0.2 2.6 2 0 0 2 2 2 2 Receptor L domain Pkinase PF00069.25 VDK73786.1 - 8.7e-39 133.5 0.0 1.6e-38 132.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 VDK73786.1 - 6.5e-18 65.0 41.6 6.5e-18 65.0 41.6 5.1 3 1 2 5 5 5 1 Furin-like cysteine rich region GF_recep_IV PF14843.6 VDK73786.1 - 3.9e-07 29.9 120.5 1.1e-05 25.2 17.0 7.5 2 2 4 6 6 6 4 Growth factor receptor domain IV Haspin_kinase PF12330.8 VDK73786.1 - 0.0016 17.5 0.1 0.0027 16.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 VDK73786.1 - 0.026 13.8 0.1 0.045 13.1 0.1 1.3 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 VDK73786.1 - 0.044 13.4 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 VDK73786.1 - 0.056 12.8 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK73786.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Katanin_con80 PF13925.6 VDK73788.1 - 1.1e-27 97.0 0.1 2.5e-27 95.9 0.1 1.5 1 0 0 1 1 1 1 con80 domain of Katanin WD40 PF00400.32 VDK73788.1 - 4.6e-12 46.3 0.2 0.00071 20.3 0.0 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK73788.1 - 9.9e-05 22.6 0.0 0.043 14.1 0.0 3.2 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK73788.1 - 0.014 15.2 0.0 0.17 11.8 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A S1-like PF14444.6 VDK73790.1 - 3.8e-30 103.6 0.3 9.2e-30 102.4 0.3 1.7 1 0 0 1 1 1 1 S1-like DBC1 PF14443.6 VDK73790.1 - 1.9e-29 102.2 0.7 1.7e-20 73.2 0.0 3.7 3 1 1 4 4 4 2 DBC1 SAP PF02037.27 VDK73790.1 - 6.4e-10 38.6 0.8 1.6e-09 37.3 0.8 1.8 1 0 0 1 1 1 1 SAP domain EF-hand_7 PF13499.6 VDK73790.1 - 0.026 15.0 0.1 0.097 13.1 0.1 2.1 1 0 0 1 1 1 0 EF-hand domain pair Mitoc_L55 PF09776.9 VDK73791.1 - 4.1e-24 84.6 1.4 4.8e-24 84.3 1.4 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L55 Phage_TAC_5 PF08890.11 VDK73791.1 - 0.044 13.8 0.0 0.059 13.4 0.0 1.2 1 0 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC Prok-E2_B PF14461.6 VDK73791.1 - 0.078 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Glycos_transf_2 PF00535.26 VDK73792.1 - 1.6e-34 119.1 0.0 1.9e-34 118.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 VDK73792.1 - 5.7e-15 55.8 0.0 7.5e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 VDK73792.1 - 3.6e-07 30.0 0.0 4.6e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 VDK73792.1 - 4.9e-05 22.9 0.0 8.6e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 VDK73792.1 - 0.011 16.3 0.0 0.027 15.0 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferase family 2 DUF4528 PF15031.6 VDK73793.1 - 2.9e-37 127.5 0.2 5.4e-37 126.7 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4528) PB1 PF00564.24 VDK73793.1 - 6e-12 45.3 0.0 1.2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 PB1 domain PDZ PF00595.24 VDK73793.1 - 2.8e-10 40.4 0.2 5.2e-10 39.5 0.2 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK73793.1 - 1.4e-07 31.3 0.2 3.2e-07 30.1 0.2 1.6 1 0 0 1 1 1 1 PDZ domain RWD PF05773.22 VDK73795.1 - 1.4e-19 70.4 0.1 2.7e-19 69.6 0.1 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 VDK73795.1 - 8.8e-07 29.3 0.4 8.8e-07 29.3 0.4 2.2 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 M20_dimer PF07687.14 VDK73797.1 - 2e-20 72.7 0.1 3.3e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 VDK73797.1 - 2.4e-20 73.1 0.2 4e-19 69.1 0.2 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 VDK73797.1 - 0.037 13.7 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 Astacin PF01400.24 VDK73834.1 - 4.1e-46 157.0 0.2 6.3e-46 156.4 0.2 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 VDK73834.1 - 0.00013 21.8 0.1 0.019 14.8 0.0 2.3 2 0 0 2 2 2 1 Matrixin Reprolysin_5 PF13688.6 VDK73834.1 - 0.0094 16.1 0.1 0.018 15.2 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 VDK73834.1 - 0.015 15.2 0.0 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like CUB PF00431.20 VDK73834.1 - 0.015 15.6 0.5 0.73 10.2 0.1 2.7 2 1 0 2 2 2 0 CUB domain Reprolysin_3 PF13582.6 VDK73834.1 - 0.051 14.1 0.0 0.24 11.9 0.1 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 VDK73834.1 - 0.068 12.8 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M7 PF02031.16 VDK73834.1 - 0.086 13.0 1.2 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M57 PF12388.8 VDK73834.1 - 0.088 12.4 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 VDK73834.1 - 0.11 11.7 0.3 0.21 10.8 0.3 1.3 1 0 0 1 1 1 0 Met-zincin Motile_Sperm PF00635.26 VDK73837.1 - 5.9e-25 87.2 0.0 6.5e-25 87.1 0.0 1.0 1 0 0 1 1 1 1 MSP (Major sperm protein) domain TMF_DNA_bd PF12329.8 VDK73838.1 - 0.0046 16.9 18.3 0.031 14.3 1.0 2.9 2 1 0 2 2 2 2 TATA element modulatory factor 1 DNA binding Atg14 PF10186.9 VDK73838.1 - 0.0085 15.2 11.2 0.033 13.3 0.7 2.1 1 1 1 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 ATG16 PF08614.11 VDK73838.1 - 0.025 14.8 17.1 1.8 8.7 7.6 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 VDK73838.1 - 0.028 13.3 18.2 0.034 13.0 1.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein HIP1_clath_bdg PF16515.5 VDK73838.1 - 0.06 14.0 16.4 0.66 10.6 0.4 3.2 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 T4SS PF07996.11 VDK73838.1 - 0.068 13.6 6.8 0.13 12.6 3.2 2.3 1 1 0 2 2 2 0 Type IV secretion system proteins DUF267 PF03268.14 VDK73838.1 - 0.085 11.7 0.2 0.13 11.1 0.2 1.2 1 0 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF267 Tropomyosin PF00261.20 VDK73838.1 - 0.13 11.6 18.5 0.17 11.3 10.4 2.1 1 1 1 2 2 2 0 Tropomyosin DUF1192 PF06698.11 VDK73838.1 - 0.29 11.2 10.5 1.5 9.0 1.6 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) Methyltransf_32 PF13679.6 VDK73838.1 - 0.3 11.1 2.2 0.58 10.1 2.3 1.6 1 1 0 1 1 1 0 Methyltransferase domain DUF2203 PF09969.9 VDK73838.1 - 0.37 11.5 10.1 0.53 11.0 3.9 2.3 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Laminin_II PF06009.12 VDK73838.1 - 0.5 10.4 9.8 0.18 11.9 1.0 2.2 1 1 1 2 2 2 0 Laminin Domain II Mod_r PF07200.13 VDK73838.1 - 0.51 10.4 13.3 5.4 7.1 0.2 3.0 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF641 PF04859.12 VDK73838.1 - 0.67 10.3 13.5 6.1 7.2 0.4 3.1 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF948 PF06103.11 VDK73838.1 - 0.67 10.3 6.1 4.1 7.7 0.2 2.8 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) UPF0242 PF06785.11 VDK73838.1 - 1 9.4 16.6 35 4.4 16.4 2.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CRR7 PF12095.8 VDK73838.1 - 1 9.8 4.8 1.6 9.2 0.6 2.6 2 1 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 DUF4407 PF14362.6 VDK73838.1 - 1.2 8.4 11.4 3.3 7.0 11.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) GAT PF03127.14 VDK73838.1 - 1.6 9.1 10.2 0.23 11.8 1.3 3.2 2 1 1 3 3 3 0 GAT domain Fzo_mitofusin PF04799.13 VDK73838.1 - 1.9 8.0 9.4 1.4 8.5 1.1 2.7 1 1 2 3 3 3 0 fzo-like conserved region ZapB PF06005.12 VDK73838.1 - 2.3 8.7 11.7 7.7e+02 0.6 11.7 3.2 1 1 0 1 1 1 0 Cell division protein ZapB Fez1 PF06818.15 VDK73838.1 - 3.1 8.2 14.2 11 6.4 5.2 2.2 1 1 1 2 2 2 0 Fez1 SlyX PF04102.12 VDK73838.1 - 3.7 8.2 11.3 3.9 8.2 0.3 3.6 2 1 1 3 3 3 0 SlyX Bap31_Bap29_C PF18035.1 VDK73838.1 - 3.7 7.6 13.4 1.1 9.4 4.7 3.6 3 1 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain XhlA PF10779.9 VDK73838.1 - 4.4 7.6 7.2 18 5.7 1.1 3.0 2 2 0 2 2 2 0 Haemolysin XhlA TPR_MLP1_2 PF07926.12 VDK73838.1 - 4.8 7.3 15.7 7 6.7 1.3 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4140 PF13600.6 VDK73838.1 - 5 7.6 16.7 37 4.8 1.3 3.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DPM3 PF08285.11 VDK73838.1 - 5.1 7.4 5.0 45 4.3 0.0 3.2 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Cob_adeno_trans PF01923.18 VDK73838.1 - 5.3 7.2 7.4 2.6e+02 1.7 7.4 2.2 1 1 0 1 1 1 0 Cobalamin adenosyltransferase PCRF PF03462.18 VDK73838.1 - 5.7 6.8 12.7 0.88 9.4 6.9 2.1 1 1 0 2 2 2 0 PCRF domain Cauli_AT PF03233.13 VDK73838.1 - 5.8 6.8 8.7 1.6 8.6 1.9 2.6 1 1 1 2 2 2 0 Aphid transmission protein DUF1542 PF07564.11 VDK73838.1 - 7.8 6.7 9.4 1 9.5 3.7 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) DUF1664 PF07889.12 VDK73838.1 - 9.4 6.3 10.0 72 3.4 6.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 VDK73838.1 - 9.7 4.0 8.8 8.9 4.1 7.4 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.14 VDK73838.1 - 9.9 5.9 14.1 7 6.4 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Cation_efflux PF01545.21 VDK73842.1 - 3e-25 89.1 13.0 4e-25 88.7 13.0 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 VDK73842.1 - 7.8e-12 45.2 1.1 1.6e-11 44.2 1.1 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF1129 PF06570.11 VDK73842.1 - 0.014 14.9 0.6 0.023 14.2 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF3043 PF11241.8 VDK73842.1 - 2.3 8.2 5.3 1.9 8.5 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) Glyco_hydro_18 PF00704.28 VDK73843.1 - 7.2e-50 170.5 0.3 8.7e-50 170.2 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Syntaxin-6_N PF09177.11 VDK73844.1 - 0.031 14.8 0.1 15 6.2 0.1 3.4 3 0 0 3 3 3 0 Syntaxin 6, N-terminal PH PF00169.29 VDK73844.1 - 0.034 14.7 0.2 0.15 12.5 0.1 2.2 2 0 0 2 2 2 0 PH domain DUF4359 PF14271.6 VDK73844.1 - 0.11 13.2 0.1 0.55 11.0 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4359) Pkinase PF00069.25 VDK73846.1 - 5.5e-64 216.1 0.4 5.7e-63 212.7 0.0 2.6 2 0 0 2 2 2 1 Protein kinase domain PKK PF12474.8 VDK73846.1 - 5.7e-51 172.3 71.5 3.2e-29 101.8 26.9 4.7 4 1 1 5 5 5 2 Polo kinase kinase Pkinase_Tyr PF07714.17 VDK73846.1 - 9.3e-51 172.6 0.0 2.5e-50 171.2 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase LRRFIP PF09738.9 VDK73847.1 - 2.3e-57 194.8 24.1 2.3e-57 194.8 24.1 2.1 2 0 0 2 2 2 1 LRRFIP family ATG16 PF08614.11 VDK73847.1 - 3.7e-06 27.3 16.4 3.7e-06 27.3 16.4 3.3 3 0 0 3 3 3 2 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 VDK73847.1 - 0.006 16.4 6.2 0.006 16.4 6.2 4.2 3 1 0 4 4 4 2 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 VDK73847.1 - 0.21 11.6 23.7 0.35 10.9 2.5 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF812 PF05667.11 VDK73847.1 - 0.22 10.4 37.0 0.26 10.1 16.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) FPP PF05911.11 VDK73847.1 - 2.3 6.3 34.0 6.6 4.8 34.0 1.7 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil MPS2 PF17060.5 VDK73847.1 - 4.1 6.6 31.9 0.36 10.0 9.6 3.7 2 2 2 4 4 4 0 Monopolar spindle protein 2 FlaC_arch PF05377.11 VDK73847.1 - 6.8 7.2 19.5 26 5.3 0.2 5.7 4 1 2 6 6 6 0 Flagella accessory protein C (FlaC) Ribonucleas_3_3 PF14622.6 VDK73849.1 - 0.012 15.7 0.1 0.026 14.7 0.1 1.5 1 1 0 1 1 1 0 Ribonuclease-III-like dsrm PF00035.26 VDK73849.1 - 0.028 15.1 0.0 0.066 13.9 0.0 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding motif SH3_1 PF00018.28 VDK73851.1 - 2.2e-39 132.8 0.2 4.6e-10 38.9 0.0 4.3 4 0 0 4 4 4 4 SH3 domain SH3_9 PF14604.6 VDK73851.1 - 2.3e-34 117.0 0.0 3.8e-09 36.3 0.1 4.4 4 0 0 4 4 4 4 Variant SH3 domain SH3_2 PF07653.17 VDK73851.1 - 5.1e-29 99.7 0.0 2.7e-09 36.6 0.0 4.3 4 0 0 4 4 4 4 Variant SH3 domain DUF5348 PF17295.2 VDK73851.1 - 0.063 13.2 1.0 5.9 6.9 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5348) KGK PF08872.10 VDK73851.1 - 0.15 12.5 1.8 11 6.5 0.0 3.2 2 1 1 3 3 3 0 KGK domain Bromo_TP PF07524.13 VDK73852.1 - 2.8e-20 72.1 0.2 5.3e-20 71.2 0.2 1.5 1 0 0 1 1 1 1 Bromodomain associated TAF8_C PF10406.9 VDK73852.1 - 6.6e-15 55.4 0.3 1.7e-14 54.1 0.3 1.8 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP_like PF17027.5 VDK73852.1 - 2.3e-05 24.5 0.1 6.4e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 Histone-fold protein TAF4 PF05236.14 VDK73852.1 - 0.0032 17.3 0.7 0.0059 16.4 0.7 1.6 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family CENP-T_C PF15511.6 VDK73852.1 - 0.025 14.7 0.0 0.067 13.3 0.0 1.7 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 VDK73852.1 - 0.041 14.2 3.7 0.099 12.9 0.1 2.9 2 1 1 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 VDK73852.1 - 0.087 13.0 0.2 0.18 12.0 0.2 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 VDK73852.1 - 0.13 12.7 0.1 0.3 11.5 0.1 1.7 1 0 0 1 1 1 0 CENP-S protein Aminotran_4 PF01063.19 VDK73852.1 - 0.13 12.1 0.0 3.5 7.4 0.0 2.6 2 1 1 3 3 3 0 Amino-transferase class IV AAA_33 PF13671.6 VDK73855.1 - 1.5e-09 38.2 0.0 3.4e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain Smr PF01713.21 VDK73855.1 - 4.9e-05 23.6 0.1 0.00036 20.8 0.0 2.4 3 0 0 3 3 3 1 Smr domain AAA_24 PF13479.6 VDK73855.1 - 0.0016 18.2 0.0 0.0039 16.9 0.0 1.6 2 0 0 2 2 2 1 AAA domain 6PF2K PF01591.18 VDK73855.1 - 0.009 15.3 0.0 0.02 14.2 0.0 1.5 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Zeta_toxin PF06414.12 VDK73855.1 - 0.0094 15.2 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin DUF2075 PF09848.9 VDK73855.1 - 0.03 13.6 0.0 0.65 9.2 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 VDK73855.1 - 0.16 12.5 0.1 1 9.9 0.1 2.4 1 1 0 1 1 1 0 AAA domain Sds3 PF08598.11 VDK73856.1 - 7.3e-08 32.7 19.2 5.3e-07 29.9 19.2 1.8 1 1 0 1 1 1 1 Sds3-like FapA PF03961.13 VDK73856.1 - 0.086 11.4 4.9 0.11 11.0 4.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A RdRP_1 PF00680.20 VDK73856.1 - 0.14 10.7 2.3 0.17 10.4 2.3 1.1 1 0 0 1 1 1 0 RNA dependent RNA polymerase Focal_AT PF03623.13 VDK73856.1 - 0.27 11.2 3.3 0.51 10.3 3.3 1.4 1 1 0 1 1 1 0 Focal adhesion targeting region PP2C_C PF07830.13 VDK73856.1 - 1.3 9.6 7.3 0.77 10.3 3.6 2.3 1 1 1 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain VPS13 PF16908.5 VDK73879.1 - 2.2e-66 224.0 9.9 8.1e-63 212.4 5.4 4.6 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 VDK73879.1 - 1.8e-51 174.9 16.0 3.6e-45 154.2 0.1 5.7 5 2 0 5 5 5 2 Repeating coiled region of VPS13 Chorein_N PF12624.7 VDK73879.1 - 1.8e-34 118.3 2.2 7.8e-34 116.3 0.1 3.1 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 DUF2126 PF09899.9 VDK73879.1 - 0.024 12.7 2.0 0.04 12.0 2.0 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) Alkyl_sulf_C PF14864.6 VDK73879.1 - 0.094 13.0 0.1 0.33 11.2 0.1 2.0 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal Syja_N PF02383.18 VDK73880.1 - 4.9e-73 246.2 0.0 1.1e-72 245.0 0.0 1.6 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 VDK73880.1 - 1.1e-11 44.4 0.1 1e-10 41.3 0.0 2.4 2 1 1 3 3 3 1 Inositol phosphatase Toxin_R_bind_C PF07951.12 VDK73880.1 - 0.077 12.6 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Clostridium neurotoxin, C-terminal receptor binding ubiquitin PF00240.23 VDK73884.1 - 0.0043 16.8 0.0 0.0083 15.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 VDK73884.1 - 0.0058 16.5 0.7 0.011 15.7 0.7 1.5 1 0 0 1 1 1 1 UBA/TS-N domain HOIP-UBA PF16678.5 VDK73884.1 - 0.098 12.7 0.1 0.21 11.6 0.1 1.7 1 1 0 1 1 1 0 HOIP UBA domain pair Ccdc124 PF06244.12 VDK73886.1 - 1.2e-34 119.6 11.3 1.2e-34 119.6 11.3 2.1 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 FeoB_C PF07664.12 VDK73886.1 - 0.11 12.2 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B C terminus AC_N PF16214.5 VDK73886.1 - 0.77 8.8 8.1 0.84 8.7 8.1 1.1 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Peptidase_S46 PF10459.9 VDK73886.1 - 5.2 5.6 22.4 14 4.1 22.4 1.6 1 1 0 1 1 1 0 Peptidase S46 Lectin_C PF00059.21 VDK73887.1 - 3.6e-11 43.7 4.0 3.8e-11 43.7 3.5 1.3 1 1 0 1 1 1 1 Lectin C-type domain PRY PF13765.6 VDK73887.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 SPRY-associated domain Homeodomain PF00046.29 VDK73890.1 - 1.9e-47 158.9 14.7 3.9e-17 61.9 2.1 3.9 3 0 0 3 3 3 3 Homeodomain Homeobox_KN PF05920.11 VDK73890.1 - 1.6e-08 34.3 0.3 0.0017 18.2 0.0 4.1 3 0 0 3 3 3 2 Homeobox KN domain zf-C2H2 PF00096.26 VDK73890.1 - 3.2e-08 33.6 76.9 0.071 13.6 2.5 11.5 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK73890.1 - 7.5e-06 26.4 77.5 0.16 12.9 0.6 11.8 11 1 0 11 11 11 6 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 VDK73890.1 - 0.0036 16.9 1.0 0.0036 16.9 1.0 6.3 6 1 1 7 7 7 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-H2C2_5 PF13909.6 VDK73890.1 - 0.76 9.6 11.6 0.74 9.6 5.0 3.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 VDK73891.1 - 0.0019 18.5 3.7 0.71 10.2 0.4 2.1 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 VDK73891.1 - 0.0055 16.7 2.1 0.099 12.7 0.1 2.5 2 0 0 2 2 2 1 BED zinc finger zf-H2C2_5 PF13909.6 VDK73891.1 - 0.029 14.1 0.2 0.067 13.0 0.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 VDK73891.1 - 0.065 14.1 6.6 4.8 8.3 1.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 VDK73891.1 - 0.15 12.5 0.7 0.15 12.5 0.7 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Elf1 PF05129.13 VDK73891.1 - 0.27 11.3 3.1 2.5 8.2 1.3 2.4 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like zf-CHY PF05495.12 VDK73891.1 - 0.38 11.3 6.7 2.1 8.9 0.8 2.2 2 0 0 2 2 2 0 CHY zinc finger zf-C2H2 PF00096.26 VDK73893.1 - 2.2e-09 37.2 24.1 0.00072 19.9 0.9 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 VDK73893.1 - 1.6e-08 34.2 23.6 0.00029 20.5 1.5 4.8 4 0 0 4 4 4 3 C2H2-type zinc-finger domain zf-met PF12874.7 VDK73893.1 - 9.9e-05 22.6 1.2 9.9e-05 22.6 1.2 3.7 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 VDK73893.1 - 0.0034 18.1 22.7 0.098 13.5 1.8 4.8 5 0 0 5 5 4 2 C2H2-type zinc finger LIM_bind PF01803.16 VDK73893.1 - 0.009 15.6 0.1 0.014 15.0 0.1 1.3 1 0 0 1 1 1 1 LIM-domain binding protein AKAP95 PF04988.12 VDK73893.1 - 0.02 15.1 0.2 0.02 15.1 0.2 3.4 3 1 0 4 4 4 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_2 PF12756.7 VDK73893.1 - 0.029 14.7 25.9 1.5 9.2 0.7 4.6 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) CpXC PF14353.6 VDK73893.1 - 0.03 14.4 6.8 5.4 7.1 0.1 3.3 3 0 0 3 3 3 0 CpXC protein DUF1415 PF07209.12 VDK73893.1 - 0.082 12.7 0.1 0.15 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1415) zf-H2C2_2 PF13465.6 VDK73893.1 - 0.083 13.4 22.6 2.9 8.5 1.7 5.7 5 0 0 5 5 5 0 Zinc-finger double domain zinc_ribbon_15 PF17032.5 VDK73893.1 - 0.72 10.6 10.3 19 6.1 6.1 2.8 2 1 0 2 2 2 0 zinc-ribbon family Elf1 PF05129.13 VDK73893.1 - 6.6 6.9 15.9 8 6.6 7.3 3.8 2 2 1 3 3 3 0 Transcription elongation factor Elf1 like Piwi PF02171.17 VDK73916.1 - 2.6e-107 358.6 0.4 3.8e-107 358.0 0.4 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 VDK73916.1 - 2.7e-13 49.9 0.0 6.3e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 VDK73916.1 - 1.1e-11 44.3 0.0 2.5e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoN PF16486.5 VDK73916.1 - 3.3e-10 40.7 0.0 6.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoMid PF16487.5 VDK73916.1 - 3.5e-08 33.6 0.0 7.8e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Mid domain of argonaute ArgoL2 PF16488.5 VDK73916.1 - 2.1e-07 31.2 0.0 6e-07 29.7 0.0 1.9 1 0 0 1 1 1 1 Argonaute linker 2 domain Motile_Sperm PF00635.26 VDK73918.1 - 6.7e-15 54.9 0.6 1.1e-14 54.2 0.2 1.5 2 0 0 2 2 2 1 MSP (Major sperm protein) domain MAP17 PF15807.5 VDK73918.1 - 0.055 13.7 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Motile_Sperm PF00635.26 VDK73922.1 - 3.4e-13 49.4 0.7 4.6e-13 49.0 0.0 1.6 2 0 0 2 2 2 1 MSP (Major sperm protein) domain Pkinase PF00069.25 VDK73923.1 - 1.5e-21 76.9 0.1 1.8e-21 76.7 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK73923.1 - 1.6e-14 53.8 0.0 1.9e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK73923.1 - 0.004 16.0 0.0 0.0067 15.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK73923.1 - 0.009 16.0 0.0 0.84 9.5 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 VDK73923.1 - 0.059 13.0 0.0 4.1 7.0 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Clathrin_bdg PF15045.6 VDK73926.1 - 4.1e-05 23.5 0.2 0.00015 21.7 0.2 2.0 1 0 0 1 1 1 1 Clathrin-binding box of Aftiphilin, vesicle trafficking Metallophos PF00149.28 VDK73927.1 - 4.7e-31 108.9 0.0 6.7e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK73927.1 - 0.039 14.4 1.4 0.046 14.2 0.2 1.8 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 VDK73927.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain BORG_CEP PF14957.6 VDK73927.1 - 5.4 8.2 8.4 9.2 7.4 8.4 1.3 1 0 0 1 1 1 0 Cdc42 effector Pkinase PF00069.25 VDK73928.1 - 5.1e-29 101.4 0.1 2.7e-26 92.5 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK73928.1 - 2.7e-17 62.9 0.0 3.8e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK73928.1 - 0.0066 16.4 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 VDK73928.1 - 0.019 14.0 0.0 0.032 13.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 VDK73928.1 - 0.026 13.3 0.3 3.7 6.2 0.0 2.1 1 1 1 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 VDK73928.1 - 0.053 13.1 0.5 0.098 12.2 0.4 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase ASD1 PF08688.10 VDK73932.1 - 0.051 14.0 0.0 0.087 13.2 0.0 1.3 1 0 0 1 1 1 0 Apx/Shroom domain ASD1 G2F PF07474.12 VDK73934.1 - 6.2e-55 185.8 0.1 6.2e-55 185.8 0.1 1.6 2 0 0 2 2 1 1 G2F domain EGF_3 PF12947.7 VDK73934.1 - 9.9e-45 150.4 207.4 4.3e-09 36.4 9.9 14.9 14 0 0 14 14 14 11 EGF domain Ldl_recept_b PF00058.17 VDK73934.1 - 1.1e-21 77.0 7.6 8.7e-07 29.3 0.0 6.1 6 0 0 6 6 5 5 Low-density lipoprotein receptor repeat class B EGF PF00008.27 VDK73934.1 - 2.1e-13 50.3 189.6 0.0031 17.8 5.6 15.0 14 0 0 14 14 14 10 EGF-like domain EGF_CA PF07645.15 VDK73934.1 - 1.2e-12 47.8 19.2 8.4e-12 45.1 8.8 14.1 13 1 1 14 14 12 5 Calcium-binding EGF domain NIDO PF06119.14 VDK73934.1 - 1e-11 45.6 2.0 1e-11 45.6 2.0 2.0 2 0 0 2 2 1 1 Nidogen-like EGF_MSP1_1 PF12946.7 VDK73934.1 - 3.8e-08 33.2 175.3 0.0011 19.0 6.4 13.4 14 0 0 14 14 12 10 MSP1 EGF domain 1 FXa_inhibition PF14670.6 VDK73934.1 - 7.8e-08 32.5 5.9 7.8e-08 32.5 5.9 13.6 12 1 0 13 13 12 4 Coagulation Factor Xa inhibitory site hEGF PF12661.7 VDK73934.1 - 0.00041 20.9 11.3 0.0021 18.6 1.8 16.4 16 1 0 16 16 14 3 Human growth factor-like EGF cEGF PF12662.7 VDK73934.1 - 0.003 17.4 1.9 0.003 17.4 1.9 13.0 14 0 0 14 14 13 7 Complement Clr-like EGF-like DUF5050 PF16472.5 VDK73934.1 - 0.0052 16.1 3.4 0.0066 15.7 0.0 2.8 4 0 0 4 4 4 1 Domain of unknown function (DUF5050) SGL PF08450.12 VDK73934.1 - 0.014 15.0 0.3 38 3.7 0.0 3.3 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 VDK73934.1 - 0.13 12.5 0.0 6.9 6.9 0.0 3.4 2 1 1 3 3 3 0 Arylesterase TGF_beta PF00019.20 VDK73970.1 - 2.8e-31 108.5 0.4 8.6e-31 107.0 0.4 1.9 1 0 0 1 1 1 1 Transforming growth factor beta like domain ApeC PF16977.5 VDK73970.1 - 0.047 13.6 0.1 0.087 12.7 0.1 1.4 1 0 0 1 1 1 0 C-terminal domain of apextrin DUF4448 PF14610.6 VDK73970.1 - 0.052 13.3 0.4 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF382 PF04037.13 VDK73970.1 - 0.65 10.2 6.6 3 8.0 1.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF382) Laminin_EGF PF00053.24 VDK73972.1 - 0.088 13.0 21.6 3.4 7.9 9.1 3.2 1 1 2 3 3 3 0 Laminin EGF domain COX14 PF14880.6 VDK73972.1 - 0.15 11.9 0.1 0.27 11.1 0.1 1.3 1 0 0 1 1 1 0 Cytochrome oxidase c assembly EGF_2 PF07974.13 VDK73972.1 - 2 8.9 25.5 0.38 11.2 3.2 4.0 3 1 1 4 4 4 0 EGF-like domain DSL PF01414.19 VDK73972.1 - 6.1 7.2 17.1 1.7 9.0 10.9 2.8 1 1 1 2 2 2 0 Delta serrate ligand GTP_EFTU PF00009.27 VDK73976.1 - 1.8e-18 66.8 0.0 3e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 VDK73976.1 - 1.5e-06 28.5 0.0 3.8e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 VDK73976.1 - 0.00061 19.9 0.0 0.0015 18.6 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FpoO PF10621.9 VDK73976.1 - 0.094 13.0 0.0 1.7 9.0 0.0 2.8 2 1 0 2 2 2 0 F420H2 dehydrogenase subunit FpoO ABC_tran PF00005.27 VDK73976.1 - 0.17 12.4 0.1 0.32 11.5 0.1 1.4 1 0 0 1 1 1 0 ABC transporter Striatin PF08232.12 VDK73979.1 - 2e-42 145.4 4.7 2e-42 145.4 4.7 3.2 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 VDK73979.1 - 1.8e-30 104.5 7.1 6.1e-07 30.1 0.2 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK73979.1 - 1.9e-07 31.3 0.2 0.019 15.2 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 VDK73979.1 - 0.0002 20.3 0.0 0.3 9.8 0.0 3.2 2 1 1 3 3 3 2 Nup133 N terminal like Pkinase_Tyr PF07714.17 VDK73980.1 - 7.5e-91 304.0 0.0 1.2e-90 303.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK73980.1 - 7e-37 127.2 0.0 1.1e-36 126.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain MAM PF00629.23 VDK73980.1 - 3.1e-23 82.4 3.0 6.1e-14 52.3 0.1 2.7 2 1 0 2 2 2 2 MAM domain, meprin/A5/mu Gly_rich PF12810.7 VDK73980.1 - 5.1e-20 72.4 19.5 8.6e-20 71.7 19.5 1.3 1 0 0 1 1 1 1 Glycine rich protein Pkinase_fungal PF17667.1 VDK73980.1 - 0.011 14.6 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 VDK73980.1 - 0.037 13.3 0.0 3.4 6.9 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Ldl_recept_a PF00057.18 VDK73980.1 - 0.048 13.9 7.8 0.17 12.1 7.8 2.1 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A Pkinase PF00069.25 VDK73982.1 - 5.2e-10 39.1 1.5 8.4e-10 38.4 1.5 1.3 1 0 0 1 1 1 1 Protein kinase domain MBOAT PF03062.19 VDK73983.1 - 2.2e-26 93.1 31.6 3.4e-26 92.4 31.6 1.3 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family PPI_Ypi1 PF07491.11 VDK73984.1 - 1.4e-15 56.8 0.6 1.4e-15 56.8 0.6 1.5 2 0 0 2 2 2 1 Protein phosphatase inhibitor LBP_BPI_CETP_C PF02886.17 VDK73988.1 - 4.1e-18 65.7 0.1 7.2e-18 64.9 0.1 1.4 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain SNF2_N PF00176.23 VDK73990.1 - 1.4e-54 185.2 0.3 1.4e-54 185.2 0.3 2.5 2 0 0 2 2 2 1 SNF2 family N-terminal domain HSA PF07529.13 VDK73990.1 - 1.1e-16 60.9 16.9 1.1e-16 60.9 16.9 3.3 3 0 0 3 3 3 1 HSA QLQ PF08880.11 VDK73990.1 - 8.8e-08 31.8 0.6 2.1e-07 30.6 0.6 1.7 1 0 0 1 1 1 1 QLQ BRK PF07533.16 VDK73990.1 - 2.1e-06 27.3 0.0 5.2e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 BRK domain DEAD PF00270.29 VDK73990.1 - 5.4e-05 23.0 0.3 0.00019 21.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Nucleoporin_FG PF13634.6 VDK74008.1 - 2.2e-05 25.2 25.1 0.00079 20.2 12.9 2.6 1 1 1 2 2 2 2 Nucleoporin FG repeat region Polysacc_synt_4 PF04669.13 VDK74009.1 - 8.8e-12 45.0 0.7 1.2e-07 31.5 0.0 2.1 1 1 1 2 2 2 2 Polysaccharide biosynthesis DUF1106 PF06523.11 VDK74009.1 - 0.0055 16.7 0.4 0.018 15.1 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1106) Ribosomal_L7Ae PF01248.26 VDK74010.1 - 1e-27 95.7 2.0 1.4e-27 95.2 2.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Calx-beta PF03160.14 VDK74011.1 - 1.4e-11 44.4 5.1 5e-09 36.2 3.5 2.3 2 1 0 2 2 2 2 Calx-beta domain PIF1 PF05970.14 VDK74011.1 - 0.054 12.7 0.3 0.07 12.3 0.3 1.1 1 0 0 1 1 1 0 PIF1-like helicase RRM_1 PF00076.22 VDK74012.1 - 3.4e-50 167.8 0.0 2.2e-16 59.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 VDK74012.1 - 4.9e-06 26.5 0.0 3.3 7.8 0.0 3.9 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.5 VDK74012.1 - 5.8e-05 23.1 0.0 0.19 11.9 0.0 3.6 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 VDK74012.1 - 0.16 11.8 0.0 1.9 8.4 0.0 2.6 3 0 0 3 3 3 0 Occluded RNA-recognition motif GST_N_4 PF17172.4 VDK74013.1 - 3.6e-26 91.8 0.1 6.8e-26 90.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 VDK74013.1 - 1.7e-23 82.2 0.1 4.2e-23 80.9 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 VDK74013.1 - 4e-07 30.4 0.0 7.8e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 VDK74013.1 - 1.8e-06 27.8 0.0 4.9e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 VDK74013.1 - 0.0012 19.0 0.0 0.0027 17.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 VDK74013.1 - 0.14 12.6 0.0 0.42 11.1 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain DIX PF00778.17 VDK74014.1 - 3e-08 33.4 0.5 8.3e-08 32.0 0.0 2.0 2 0 0 2 2 2 1 DIX domain RGS PF00615.19 VDK74014.1 - 1.8e-05 25.0 1.4 5.7e-05 23.4 0.1 2.4 3 0 0 3 3 3 1 Regulator of G protein signaling domain Myb_DNA-binding PF00249.31 VDK74015.1 - 0.0015 18.7 0.1 5.3 7.3 0.0 3.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain Smg4_UPF3 PF03467.15 VDK74015.1 - 0.099 12.7 0.2 10 6.1 0.1 2.6 2 0 0 2 2 2 0 Smg-4/UPF3 family PB1-F2 PF11986.8 VDK74016.1 - 0.039 14.2 0.0 0.061 13.5 0.0 1.3 1 0 0 1 1 1 0 Influenza A Proapoptotic protein WWE PF02825.20 VDK74017.1 - 1.2e-14 54.6 0.4 2.2e-14 53.8 0.4 1.4 1 0 0 1 1 1 1 WWE domain zf-RING_2 PF13639.6 VDK74017.1 - 1e-09 38.6 6.6 2.3e-09 37.4 6.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 VDK74017.1 - 5.7e-08 32.5 7.1 1.3e-07 31.4 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK74017.1 - 1.6e-07 31.0 7.8 3.3e-07 30.0 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK74017.1 - 2.1e-05 24.5 3.6 2.1e-05 24.5 3.6 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK74017.1 - 2.1e-05 24.3 13.0 3.9e-05 23.4 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK74017.1 - 0.0028 17.5 14.3 0.0029 17.4 5.3 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 VDK74017.1 - 0.004 17.3 8.6 0.0098 16.0 8.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 VDK74017.1 - 0.0052 16.5 2.6 0.0052 16.5 2.6 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 VDK74017.1 - 0.01 16.1 8.4 0.027 14.7 8.4 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 VDK74017.1 - 0.013 15.5 8.2 0.013 15.5 8.2 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 VDK74017.1 - 1.2 8.9 8.9 0.18 11.6 4.8 1.8 2 0 0 2 2 1 0 RING-like zinc finger Ribosomal_S10 PF00338.22 VDK74018.1 - 1.8e-24 85.8 0.1 5.9e-24 84.2 0.1 1.8 1 1 0 1 1 1 1 Ribosomal protein S10p/S20e Hamartin PF04388.12 VDK74019.1 - 1.2 7.7 8.0 1.4 7.5 8.0 1.0 1 0 0 1 1 1 0 Hamartin protein Ribosomal_S10 PF00338.22 VDK74021.1 - 1.8e-24 85.8 0.1 5.9e-24 84.2 0.1 1.8 1 1 0 1 1 1 1 Ribosomal protein S10p/S20e WWE PF02825.20 VDK74022.1 - 1.2e-14 54.6 0.4 2.2e-14 53.8 0.4 1.4 1 0 0 1 1 1 1 WWE domain zf-RING_2 PF13639.6 VDK74022.1 - 1e-09 38.6 6.6 2.3e-09 37.4 6.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 VDK74022.1 - 5.7e-08 32.5 7.1 1.3e-07 31.4 7.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK74022.1 - 1.6e-07 31.0 7.8 3.3e-07 30.0 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK74022.1 - 2.1e-05 24.5 3.6 2.1e-05 24.5 3.6 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK74022.1 - 2.1e-05 24.3 13.0 3.9e-05 23.4 13.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK74022.1 - 0.0028 17.5 14.3 0.0029 17.4 5.3 2.3 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 VDK74022.1 - 0.004 17.3 8.6 0.0098 16.0 8.6 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 VDK74022.1 - 0.0052 16.5 2.6 0.0052 16.5 2.6 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 VDK74022.1 - 0.01 16.1 8.4 0.027 14.7 8.4 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 VDK74022.1 - 0.013 15.5 8.2 0.013 15.5 8.2 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 VDK74022.1 - 1.2 8.9 8.9 0.18 11.6 4.8 1.8 2 0 0 2 2 1 0 RING-like zinc finger PB1-F2 PF11986.8 VDK74023.1 - 0.039 14.2 0.0 0.061 13.5 0.0 1.3 1 0 0 1 1 1 0 Influenza A Proapoptotic protein Myb_DNA-binding PF00249.31 VDK74024.1 - 0.0015 18.7 0.1 5.3 7.3 0.0 3.7 3 0 0 3 3 3 2 Myb-like DNA-binding domain Smg4_UPF3 PF03467.15 VDK74024.1 - 0.099 12.7 0.2 10 6.1 0.1 2.6 2 0 0 2 2 2 0 Smg-4/UPF3 family DIX PF00778.17 VDK74025.1 - 3e-08 33.4 0.5 8.3e-08 32.0 0.0 2.0 2 0 0 2 2 2 1 DIX domain RGS PF00615.19 VDK74025.1 - 1.8e-05 25.0 1.4 5.7e-05 23.4 0.1 2.4 3 0 0 3 3 3 1 Regulator of G protein signaling domain GST_N_4 PF17172.4 VDK74026.1 - 3.6e-26 91.8 0.1 6.8e-26 90.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 VDK74026.1 - 1.7e-23 82.2 0.1 4.2e-23 80.9 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 VDK74026.1 - 4e-07 30.4 0.0 7.8e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 VDK74026.1 - 1.8e-06 27.8 0.0 4.9e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 VDK74026.1 - 0.0012 19.0 0.0 0.0027 17.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 VDK74026.1 - 0.14 12.6 0.0 0.42 11.1 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain RRM_1 PF00076.22 VDK74027.1 - 3.4e-50 167.8 0.0 2.2e-16 59.4 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 VDK74027.1 - 4.9e-06 26.5 0.0 3.3 7.8 0.0 3.9 3 0 0 3 3 3 3 RNA binding domain RRM_7 PF16367.5 VDK74027.1 - 5.8e-05 23.1 0.0 0.19 11.9 0.0 3.6 3 0 0 3 3 3 1 RNA recognition motif RRM_occluded PF16842.5 VDK74027.1 - 0.16 11.8 0.0 1.9 8.4 0.0 2.6 3 0 0 3 3 3 0 Occluded RNA-recognition motif MRP-S31 PF15433.6 VDK74054.1 - 2.8e-82 276.9 12.9 3.9e-82 276.5 12.9 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S31 AviRa PF11599.8 VDK74054.1 - 0.015 14.7 0.5 0.015 14.7 0.5 1.8 2 0 0 2 2 2 0 RRNA methyltransferase AviRa Ldh_1_C PF02866.18 VDK74056.1 - 2.6e-48 164.1 0.1 3.5e-48 163.7 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 VDK74056.1 - 1.5e-46 158.0 0.4 2.4e-46 157.3 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 VDK74056.1 - 0.00058 19.0 0.0 0.0008 18.5 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 VDK74056.1 - 0.012 15.5 0.0 0.085 12.7 0.0 2.0 2 0 0 2 2 2 0 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 VDK74056.1 - 0.022 15.0 0.0 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 VDK74056.1 - 0.047 14.1 0.0 0.41 11.1 0.0 2.4 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain AAA PF00004.29 VDK74058.1 - 3.9e-40 137.3 0.4 6e-39 133.5 0.0 2.7 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK74058.1 - 4.9e-07 30.1 0.3 0.0057 16.9 0.1 3.2 2 1 1 3 3 3 2 AAA domain AAA_2 PF07724.14 VDK74058.1 - 1.8e-06 28.2 0.0 1e-05 25.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 VDK74058.1 - 3.1e-06 27.7 0.2 0.0053 17.2 0.1 3.5 3 1 1 4 4 4 1 AAA ATPase domain AAA_lid_3 PF17862.1 VDK74058.1 - 4.3e-06 26.4 0.2 1e-05 25.2 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 VDK74058.1 - 6.7e-06 26.1 0.3 0.00014 21.8 0.1 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 VDK74058.1 - 0.00011 22.0 0.0 0.00023 21.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 VDK74058.1 - 0.0019 18.0 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein MCM PF00493.23 VDK74058.1 - 0.0019 17.3 0.1 0.63 9.1 0.0 2.4 2 0 0 2 2 2 1 MCM P-loop domain AAA_14 PF13173.6 VDK74058.1 - 0.0031 17.5 0.0 0.016 15.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 VDK74058.1 - 0.0071 15.8 0.1 0.12 11.8 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 VDK74058.1 - 0.01 15.0 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 VDK74058.1 - 0.012 15.3 0.1 0.054 13.2 0.0 2.1 2 1 0 2 2 2 0 Sigma-54 interaction domain TIP49 PF06068.13 VDK74058.1 - 0.015 14.5 0.3 0.042 13.1 0.1 1.8 2 0 0 2 2 2 0 TIP49 P-loop domain ATPase PF06745.13 VDK74058.1 - 0.018 14.4 0.2 0.26 10.6 0.1 2.3 1 1 1 2 2 2 0 KaiC AAA_7 PF12775.7 VDK74058.1 - 0.018 14.5 0.1 0.094 12.2 0.1 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 VDK74058.1 - 0.027 14.4 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 VDK74058.1 - 0.047 13.1 0.0 0.099 12.0 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 VDK74058.1 - 0.049 13.8 0.0 0.1 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 VDK74058.1 - 0.071 13.0 0.2 0.59 10.0 0.1 2.4 2 1 1 3 3 3 0 NACHT domain NB-ARC PF00931.22 VDK74058.1 - 0.087 12.0 0.1 3.2 6.9 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.12 VDK74058.1 - 0.09 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 VDK74058.1 - 0.093 13.3 0.1 0.35 11.4 0.0 2.1 3 0 0 3 3 1 0 AAA domain AAA_25 PF13481.6 VDK74058.1 - 0.12 11.9 0.0 0.33 10.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 VDK74058.1 - 0.13 12.7 0.1 0.39 11.1 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ABC_tran PF00005.27 VDK74058.1 - 0.14 12.7 0.3 0.75 10.3 0.0 2.2 2 0 0 2 2 2 0 ABC transporter TsaE PF02367.17 VDK74058.1 - 0.14 12.1 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Prot_ATP_ID_OB PF16450.5 VDK74058.1 - 0.15 12.1 0.0 0.39 10.7 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain AAA_24 PF13479.6 VDK74058.1 - 0.16 11.7 0.4 0.5 10.1 0.1 2.0 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 VDK74058.1 - 0.26 11.2 1.3 3.5 7.5 0.3 2.8 2 1 0 2 2 2 0 NTPase Neur_chan_memb PF02932.16 VDK74061.1 - 0.0016 18.6 10.1 0.0016 18.6 10.1 2.0 1 1 1 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region LAP1C PF05609.12 VDK74061.1 - 4.9 6.1 31.4 5.8 5.9 31.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BTB PF00651.31 VDK74062.1 - 0.0012 19.1 0.0 0.0027 17.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.25 VDK74063.1 - 1.4e-24 86.9 0.1 1.7e-24 86.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74063.1 - 1.2e-12 47.7 0.1 1.6e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK74063.1 - 0.0057 15.5 0.0 0.0074 15.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 VDK74063.1 - 0.0092 15.0 0.3 0.014 14.4 0.3 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 VDK74063.1 - 0.026 14.5 0.0 0.97 9.3 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 VDK74063.1 - 0.047 13.0 0.2 0.089 12.1 0.1 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family V_ATPase_I PF01496.19 VDK74064.1 - 0 1052.5 0.0 0 1052.3 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Occludin_ELL PF07303.13 VDK74064.1 - 0.015 16.0 1.0 6.3 7.6 1.4 3.0 3 0 0 3 3 3 0 Occludin homology domain APG6_N PF17675.1 VDK74064.1 - 0.2 12.2 4.4 0.35 11.4 4.4 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region FTA4 PF13093.6 VDK74064.1 - 0.23 11.3 0.9 0.33 10.8 0.2 1.5 2 0 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 YgaB PF14182.6 VDK74064.1 - 0.6 10.5 4.5 5.5 7.5 1.2 2.5 2 0 0 2 2 2 0 YgaB-like protein FlaC_arch PF05377.11 VDK74064.1 - 0.73 10.3 5.5 0.37 11.2 1.7 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DHR10 PF18595.1 VDK74064.1 - 4.3 7.4 7.2 0.77 9.8 2.9 1.9 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain TFIID_20kDa PF03847.13 VDK74067.1 - 2.5e-21 75.9 0.3 4.5e-21 75.1 0.3 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TFIID-18kDa PF02269.16 VDK74067.1 - 0.00088 19.2 0.0 0.0023 17.9 0.0 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CBFD_NFYB_HMF PF00808.23 VDK74067.1 - 0.0078 16.5 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 VDK74067.1 - 0.015 15.4 0.5 0.045 13.8 0.1 1.9 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit DUF2478 PF10649.9 VDK74067.1 - 0.03 13.9 0.0 0.067 12.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2478) Histone PF00125.24 VDK74067.1 - 0.065 13.6 0.4 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 DUF4874 PF16173.5 VDK74067.1 - 0.12 12.1 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) DUF3398 PF11878.8 VDK74067.1 - 0.35 11.3 2.5 5.8 7.4 2.5 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3398) TPR_8 PF13181.6 VDK74069.1 - 2.6e-16 58.4 6.0 1.1e-05 25.2 0.1 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK74069.1 - 5.5e-15 54.2 15.6 3.2e-05 23.7 0.6 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 VDK74069.1 - 2e-13 49.9 3.9 0.012 16.3 0.0 7.7 6 1 2 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK74069.1 - 1.7e-12 46.6 12.5 2.9e-05 23.7 0.5 6.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK74069.1 - 9.9e-11 41.3 4.7 4.8e-05 23.4 0.4 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK74069.1 - 4.7e-10 39.8 6.6 7.4e-05 23.2 1.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK74069.1 - 3.4e-08 34.0 2.1 0.00017 22.1 2.0 3.1 1 1 1 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK74069.1 - 1.1e-07 32.0 7.4 0.038 14.2 1.1 4.2 3 0 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 VDK74069.1 - 1.2e-07 31.9 10.2 0.05 13.9 0.2 5.7 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK74069.1 - 1.9e-06 27.5 5.3 0.021 14.8 0.1 5.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 VDK74069.1 - 4.3e-06 26.1 0.7 0.03 13.6 0.2 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat PPR PF01535.20 VDK74069.1 - 4.7e-06 26.5 0.9 0.14 12.5 0.0 4.9 4 0 0 4 4 4 1 PPR repeat TPR_11 PF13414.6 VDK74069.1 - 7.5e-06 25.5 4.7 0.0018 17.9 0.8 4.5 3 2 3 6 6 6 1 TPR repeat TPR_9 PF13371.6 VDK74069.1 - 0.0016 18.6 1.0 1.5 9.0 0.0 3.3 2 1 0 3 3 3 1 Tetratricopeptide repeat DUF1824 PF08854.10 VDK74069.1 - 0.037 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1824) MAR_sialic_bdg PF10564.9 VDK74069.1 - 0.046 13.8 1.7 0.24 11.5 0.1 2.7 3 0 0 3 3 3 0 Sialic-acid binding micronemal adhesive repeat PPR_2 PF13041.6 VDK74069.1 - 0.096 12.9 0.2 8.1 6.7 0.0 3.1 2 0 0 2 2 2 0 PPR repeat family TPR_6 PF13174.6 VDK74069.1 - 0.56 11.0 9.0 5 8.0 0.1 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat Clathrin PF00637.20 VDK74069.1 - 3.5 7.5 7.6 1.8 8.5 0.1 3.6 3 2 1 4 4 4 0 Region in Clathrin and VPS TBP PF00352.21 VDK74072.1 - 3.3e-65 216.1 0.1 5.1e-32 109.7 0.0 2.2 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 VDK74072.1 - 9.6e-05 22.4 0.0 0.29 11.3 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Ribosomal_L4 PF00573.22 VDK74074.1 - 1.1e-35 123.1 0.0 1.8e-35 122.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family CBF PF03914.17 VDK74074.1 - 3.6e-21 76.0 0.0 6.6e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 CBF/Mak21 family zf-HIT PF04438.16 VDK74077.1 - 0.00012 21.8 9.0 0.00022 21.0 9.0 1.5 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 VDK74077.1 - 0.043 13.9 3.2 0.043 13.9 3.2 1.9 1 1 1 2 2 2 0 MYND finger DUF1989 PF09347.10 VDK74077.1 - 0.074 12.7 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1989) Ribosomal_L21p PF00829.21 VDK74078.1 - 2.1e-15 56.8 0.6 1.1e-14 54.5 0.1 1.9 2 0 0 2 2 2 1 Ribosomal prokaryotic L21 protein Collagen PF01391.18 VDK74079.1 - 6.8e-21 73.8 101.5 1.1e-08 34.7 35.4 4.9 3 1 2 5 5 5 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK74079.1 - 1.2e-15 57.2 0.9 1.9e-15 56.7 0.9 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain PAN_1 PF00024.26 VDK74081.1 - 1.8e-20 72.7 24.5 2.6e-08 33.7 3.9 3.3 3 0 0 3 3 3 3 PAN domain BTB PF00651.31 VDK74082.1 - 1.5e-28 99.2 0.6 6e-28 97.3 0.2 2.0 1 1 1 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.15 VDK74082.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Peptidase_M10 PF00413.24 VDK74103.1 - 1.2e-35 122.7 4.4 3.7e-35 121.1 1.8 2.4 1 1 0 2 2 2 1 Matrixin Peptidase_M66 PF10462.9 VDK74103.1 - 0.00014 20.9 0.0 0.0004 19.4 0.0 1.7 2 0 0 2 2 2 1 Peptidase M66 Reprolysin_4 PF13583.6 VDK74103.1 - 0.0019 17.9 2.0 0.0054 16.4 0.0 2.2 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 VDK74103.1 - 0.002 18.7 0.7 0.002 18.7 0.7 2.7 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 VDK74103.1 - 0.0073 16.3 0.1 0.066 13.2 0.0 2.3 1 1 1 2 2 2 1 Peptidase family M54 Metallopep PF12044.8 VDK74103.1 - 0.0077 14.9 0.0 0.013 14.1 0.0 1.3 1 0 0 1 1 1 1 Putative peptidase family ACBP PF00887.19 VDK74104.1 - 1.2e-05 25.5 0.0 1.2e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 Acyl CoA binding protein FERM_M PF00373.18 VDK74104.1 - 0.03 14.7 0.2 28 5.1 0.0 3.4 3 1 1 4 4 4 0 FERM central domain DUF1491 PF07372.12 VDK74104.1 - 0.1 13.0 2.8 0.22 11.9 2.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) RNA_GG_bind PF10258.9 VDK74105.1 - 3.5e-25 87.9 0.0 6.1e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 PHAX RNA-binding domain TAP42 PF04177.12 VDK74106.1 - 2.4e-57 194.5 15.7 1e-56 192.4 15.7 1.7 1 1 0 1 1 1 1 TAP42-like family Bud13 PF09736.9 VDK74106.1 - 0.78 10.1 7.2 0.18 12.2 3.6 1.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex YWFCY PF14293.6 VDK74109.1 - 0.26 11.6 1.4 3.3 8.1 0.9 2.6 2 0 0 2 2 2 0 YWFCY protein PEN-2 PF10251.9 VDK74110.1 - 9.3e-35 118.9 2.4 1e-34 118.8 2.4 1.0 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase TMEM144 PF07857.12 VDK74112.1 - 3.4e-122 407.6 15.5 4.2e-122 407.3 15.5 1.1 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 VDK74112.1 - 1.6e-11 44.0 18.8 4e-09 36.2 7.9 2.4 2 1 0 2 2 2 2 Sugar transport protein UPF0370 PF13980.6 VDK74112.1 - 0.042 13.9 0.7 11 6.1 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) PP2C PF00481.21 VDK74114.1 - 1.3e-55 188.8 0.0 1.7e-55 188.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 VDK74114.1 - 1.8e-06 27.8 0.0 5.1e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Protein phosphatase 2C DUF4528 PF15031.6 VDK74114.1 - 0.03 14.4 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4528) MAM33 PF02330.16 VDK74117.1 - 8.9e-22 78.1 2.5 2.3e-21 76.7 2.5 1.6 1 1 0 1 1 1 1 Mitochondrial glycoprotein Herpes_UL37_1 PF03970.13 VDK74117.1 - 0.11 11.7 0.1 0.16 11.2 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL37 tegument protein Motile_Sperm PF00635.26 VDK74119.1 - 9.1e-19 67.3 0.1 9.1e-19 67.3 0.1 2.9 2 1 0 2 2 2 1 MSP (Major sperm protein) domain DUF4834 PF16118.5 VDK74119.1 - 0.034 15.1 0.2 0.034 15.1 0.2 5.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 VDK74119.1 - 0.049 13.3 0.1 0.049 13.3 0.1 6.1 1 1 2 3 3 3 0 FAM176 family Methyltransf_31 PF13847.6 VDK74120.1 - 5.8e-17 61.9 0.1 7.8e-17 61.5 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK74120.1 - 7.7e-11 42.6 0.0 1.1e-10 42.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK74120.1 - 1.3e-10 41.9 0.0 2e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK74120.1 - 2.2e-10 41.0 0.0 3.4e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK74120.1 - 1.4e-07 31.5 0.0 3.1e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK74120.1 - 2.1e-06 27.4 0.0 3e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 VDK74120.1 - 8.4e-05 22.6 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 VDK74120.1 - 0.00021 20.7 0.0 0.00029 20.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Pox_MCEL PF03291.16 VDK74120.1 - 0.00038 19.7 0.1 0.00074 18.7 0.1 1.5 1 1 0 1 1 1 1 mRNA capping enzyme PrmA PF06325.13 VDK74120.1 - 0.00077 18.9 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 VDK74120.1 - 0.0026 17.4 0.0 0.0037 16.9 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW AdoMet_MTase PF07757.13 VDK74120.1 - 0.0052 17.1 0.0 0.0083 16.5 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase TehB PF03848.14 VDK74120.1 - 0.019 14.4 0.1 0.024 14.0 0.1 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB DUF1242 PF06842.12 VDK74120.1 - 0.083 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1242) Methyltransf_18 PF12847.7 VDK74120.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain C2 PF00168.30 VDK74121.1 - 6.9e-43 145.1 0.0 1.9e-27 95.5 0.0 2.7 3 0 0 3 3 3 2 C2 domain SMP_LBD PF17047.5 VDK74121.1 - 1.8e-41 141.6 0.0 2.8e-41 141.0 0.0 1.3 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain BCAS2 PF05700.11 VDK74122.1 - 7.9e-57 192.3 7.9 9.5e-57 192.0 7.9 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) CALM_bind PF16025.5 VDK74122.1 - 0.49 10.9 4.1 8.5 6.9 2.3 2.4 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding XPG_I PF00867.18 VDK74123.1 - 3.7e-17 62.4 0.0 8.8e-17 61.2 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 VDK74123.1 - 5.3e-12 46.1 0.0 1.1e-11 45.1 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain zf-H2C2_5 PF13909.6 VDK74128.1 - 0.00046 19.9 2.2 0.013 15.3 0.1 2.9 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 VDK74128.1 - 0.026 15.0 0.4 0.026 15.0 0.4 4.3 4 0 0 4 4 4 0 Zinc finger, C2H2 type AKAP95 PF04988.12 VDK74128.1 - 0.051 13.8 3.4 0.73 10.0 0.1 2.5 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) MRP-L28 PF09812.9 VDK74128.1 - 0.087 13.0 0.5 0.15 12.2 0.5 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 zf-C2H2_11 PF16622.5 VDK74128.1 - 0.28 11.0 0.2 0.28 11.0 0.2 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 VDK74128.1 - 0.37 11.8 0.3 0.37 11.8 0.3 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 VDK74128.1 - 0.4 10.4 3.6 3.1 7.5 3.9 2.3 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Pkinase PF00069.25 VDK74130.1 - 1.8e-47 161.9 0.0 3.2e-47 161.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74130.1 - 3.1e-16 59.4 0.0 7.7e-16 58.1 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK74130.1 - 1.1e-05 24.9 0.0 2.5e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK74130.1 - 0.078 11.7 1.9 0.091 11.5 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Carb_anhydrase PF00194.21 VDK74131.1 - 1.7e-61 208.0 0.0 2e-61 207.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase PAX PF00292.18 VDK74155.1 - 2.2e-48 163.3 1.3 2.9e-48 162.9 1.3 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 VDK74155.1 - 7e-06 25.7 0.0 1.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 VDK74155.1 - 0.00034 20.6 0.0 0.00063 19.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix MarR_2 PF12802.7 VDK74155.1 - 0.0084 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_Tnp_IS1 PF12759.7 VDK74155.1 - 0.023 14.3 0.0 0.056 13.1 0.0 1.6 1 0 0 1 1 1 0 InsA C-terminal domain HTH_32 PF13565.6 VDK74155.1 - 0.16 12.6 0.1 2 9.1 0.0 2.2 1 1 1 2 2 2 0 Homeodomain-like domain Homeodomain PF00046.29 VDK74156.1 - 3e-13 49.4 0.4 4.4e-13 48.9 0.4 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK74156.1 - 0.03 14.2 0.0 0.073 13.0 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain PAX PF00292.18 VDK74157.1 - 1.1e-48 164.3 0.7 2e-48 163.5 0.7 1.4 1 0 0 1 1 1 1 'Paired box' domain Homeodomain PF00046.29 VDK74157.1 - 1.9e-21 75.7 2.5 3.6e-21 74.8 2.5 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK74157.1 - 6.4e-06 26.0 0.5 1.9e-05 24.5 0.2 1.9 2 0 0 2 2 2 1 Homeobox KN domain HTH_23 PF13384.6 VDK74157.1 - 3.9e-05 23.3 0.1 0.00052 19.7 0.0 2.3 2 0 0 2 2 2 1 Homeodomain-like domain HTH_Tnp_IS1 PF12759.7 VDK74157.1 - 0.018 14.6 0.0 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 InsA C-terminal domain HTH_32 PF13565.6 VDK74157.1 - 0.018 15.6 3.0 0.38 11.4 0.1 3.1 2 1 1 3 3 3 0 Homeodomain-like domain DUF1510 PF07423.11 VDK74157.1 - 0.18 12.0 1.9 2.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1510) MT-A70 PF05063.14 VDK74162.1 - 1.7e-34 119.2 0.1 3.1e-34 118.4 0.1 1.4 1 0 0 1 1 1 1 MT-A70 Zip PF02535.22 VDK74163.1 - 9.5e-31 107.2 14.0 9.7e-25 87.5 10.1 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter FUSC_2 PF13515.6 VDK74163.1 - 0.62 10.2 8.0 0.1 12.7 3.0 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein-like Zip PF02535.22 VDK74164.1 - 2.2e-11 43.6 1.7 2.5e-11 43.4 1.7 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter Ebp2 PF05890.12 VDK74165.1 - 1.9e-61 208.0 32.0 2.5e-61 207.6 32.0 1.2 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 zf-CRD PF17979.1 VDK74165.1 - 0.27 11.3 2.2 0.65 10.1 2.2 1.7 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions Baculo_p24 PF05073.12 VDK74165.1 - 3.2 7.5 8.8 0.91 9.3 5.2 1.9 1 1 1 2 2 2 0 Baculovirus P24 capsid protein tRNA_m1G_MT PF01746.21 VDK74166.1 - 0.0018 18.0 0.2 0.011 15.5 0.2 2.1 1 1 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase DUF2192 PF09958.9 VDK74166.1 - 0.028 14.0 0.0 0.074 12.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2192) DUF2367 PF10164.9 VDK74172.1 - 1.4e-05 25.5 7.6 2.1e-05 25.0 7.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) zf-C2H2_9 PF16293.5 VDK74172.1 - 0.044 13.6 1.0 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 VDK74172.1 - 0.14 12.4 5.5 6.7 7.1 0.1 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Sensor PF13796.6 VDK74172.1 - 0.24 11.5 0.0 0.31 11.1 0.0 1.1 1 0 0 1 1 1 0 Putative sensor zf-piccolo PF05715.13 VDK74172.1 - 0.24 11.6 6.7 0.4 10.9 0.0 2.5 2 1 0 2 2 2 0 Piccolo Zn-finger FAM184 PF15665.5 VDK74173.1 - 0.00011 22.0 22.1 0.00011 22.0 22.1 4.0 4 1 1 5 5 5 1 Family with sequence similarity 184, A and B DUF16 PF01519.16 VDK74173.1 - 0.0011 19.4 3.6 0.0011 19.4 3.6 5.3 3 1 2 5 5 5 1 Protein of unknown function DUF16 UPF0242 PF06785.11 VDK74173.1 - 0.0037 17.4 12.8 0.0037 17.4 12.8 4.8 2 2 2 4 4 3 2 Uncharacterised protein family (UPF0242) N-terminus THP2 PF09432.10 VDK74173.1 - 0.012 15.7 3.0 0.012 15.7 3.0 3.5 2 1 1 3 3 3 0 Tho complex subunit THP2 bZIP_2 PF07716.15 VDK74173.1 - 0.071 13.2 0.3 0.071 13.2 0.3 5.7 7 1 2 9 9 8 0 Basic region leucine zipper TPD52 PF04201.15 VDK74173.1 - 0.41 10.3 29.7 0.028 14.1 3.3 4.0 2 1 1 4 4 4 0 Tumour protein D52 family WXG100 PF06013.12 VDK74173.1 - 0.92 9.8 11.8 0.11 12.8 3.0 3.4 2 1 1 3 3 2 0 Proteins of 100 residues with WXG ApoO PF09769.9 VDK74173.1 - 1.1 9.3 2.7 1.3 9.0 0.5 2.4 2 0 0 2 2 2 0 Apolipoprotein O Fez1 PF06818.15 VDK74173.1 - 2 8.8 46.3 2 8.8 10.5 3.8 2 2 1 3 3 3 0 Fez1 TACC_C PF05010.14 VDK74173.1 - 3.8 7.2 43.4 0.049 13.4 8.6 4.0 3 1 1 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Baculo_PEP_C PF04513.12 VDK74173.1 - 6.1 6.9 12.2 1.7 8.7 4.8 3.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4162 PF13732.6 VDK74173.1 - 6.2 7.6 11.8 0.12 13.1 0.9 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4162) Mce4_CUP1 PF11887.8 VDK74173.1 - 6.5 6.1 6.9 3.7 6.9 4.0 1.9 1 1 1 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Aldo_ket_red PF00248.21 VDK74175.1 - 3.4e-51 174.2 0.0 5.6e-51 173.5 0.0 1.3 1 1 0 1 1 1 1 Aldo/keto reductase family MOLO1 PF17175.4 VDK74176.1 - 5.1e-18 65.3 0.4 2.8e-17 62.9 0.0 2.1 2 0 0 2 2 2 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 VDK74176.1 - 4.6e-05 23.6 0.3 0.0025 18.0 0.1 2.9 3 0 0 3 3 3 1 TPM domain CENP-B_N PF04218.13 VDK74176.1 - 0.006 16.2 0.6 0.38 10.4 0.1 2.4 2 0 0 2 2 2 2 CENP-B N-terminal DNA-binding domain TPR_2 PF07719.17 VDK74198.1 - 0.65 10.3 6.3 4.2 7.7 0.1 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat UPF0160 PF03690.13 VDK74200.1 - 1.7e-125 418.9 0.0 1.9e-125 418.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) SH3_2 PF07653.17 VDK74200.1 - 0.068 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain RRM_1 PF00076.22 VDK74201.1 - 1.6e-05 24.7 0.0 3.1e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CH PF00307.31 VDK74202.1 - 5.1e-54 181.1 1.0 3.6e-28 97.9 0.0 3.8 4 0 0 4 4 4 2 Calponin homology (CH) domain Spectrin PF00435.21 VDK74202.1 - 2.9e-50 169.1 13.7 1.3e-17 64.2 0.4 4.5 4 0 0 4 4 4 4 Spectrin repeat EFhand_Ca_insen PF08726.10 VDK74202.1 - 2.4e-25 88.4 2.4 2.4e-25 88.4 0.1 2.3 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 VDK74202.1 - 1.3e-09 37.7 0.2 6.9e-09 35.4 0.1 2.4 3 0 0 3 3 3 1 CAMSAP CH domain YkuI_C PF10388.9 VDK74202.1 - 0.011 15.6 1.7 14 5.5 0.0 3.8 3 0 0 3 3 3 0 EAL-domain associated signalling protein domain DUF3398 PF11878.8 VDK74202.1 - 0.022 15.2 0.1 0.066 13.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3398) EF-hand_7 PF13499.6 VDK74202.1 - 0.037 14.5 0.0 0.18 12.2 0.0 2.3 1 0 0 1 1 1 0 EF-hand domain pair Sulphotransf PF09037.10 VDK74202.1 - 0.059 12.9 0.4 0.18 11.3 0.0 2.0 2 0 0 2 2 2 0 Stf0 sulphotransferase Claudin_2 PF13903.6 VDK74203.1 - 0.98 9.1 6.9 0.46 10.2 4.2 1.9 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction CD20 PF04103.15 VDK74203.1 - 2.4 8.2 18.1 0.17 11.9 10.7 2.4 2 0 0 2 2 2 0 CD20-like family MFS_1 PF07690.16 VDK74204.1 - 9.7e-29 100.4 39.0 2.2e-23 82.8 25.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 VDK74204.1 - 0.0032 16.8 0.2 0.0032 16.8 0.2 3.1 3 1 1 4 4 4 2 Uncharacterised MFS-type transporter YbfB Ion_trans_2 PF07885.16 VDK74206.1 - 2.6e-34 117.0 22.3 2e-17 62.9 1.0 2.7 3 0 0 3 3 3 2 Ion channel IRK PF01007.20 VDK74206.1 - 0.013 15.3 2.8 1.1 9.0 1.0 2.3 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain Ion_trans PF00520.31 VDK74206.1 - 0.036 13.3 16.4 1.1 8.4 0.1 2.5 1 1 1 2 2 2 0 Ion transport protein PIRT PF15099.6 VDK74206.1 - 3.4 7.2 5.3 5.6 6.6 0.8 2.9 2 1 1 3 3 3 0 Phosphoinositide-interacting protein family AOX PF01786.17 VDK74207.1 - 0.14 11.7 0.1 0.17 11.4 0.1 1.0 1 0 0 1 1 1 0 Alternative oxidase Myosin_head PF00063.21 VDK74209.1 - 1.8e-286 951.8 7.4 1.8e-286 951.8 7.4 3.4 3 1 1 4 4 4 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 VDK74209.1 - 1.8e-126 423.5 265.7 6.6e-126 421.6 265.7 1.7 1 1 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 VDK74209.1 - 3.7e-09 36.3 0.7 9.5e-09 35.0 0.7 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Filament PF00038.21 VDK74209.1 - 6.5e-07 29.2 26.6 6.5e-07 29.2 26.6 8.4 1 1 6 7 7 7 3 Intermediate filament protein TolA_bind_tri PF16331.5 VDK74209.1 - 0.0019 18.2 9.3 0.0019 18.2 9.3 14.9 6 5 8 15 15 15 5 TolA binding protein trimerisation DUF2205 PF10224.9 VDK74209.1 - 0.0056 16.6 3.3 0.0056 16.6 3.3 13.8 8 5 6 16 16 16 2 Short coiled-coil protein AAA_22 PF13401.6 VDK74209.1 - 0.37 11.1 0.0 0.37 11.1 0.0 6.5 6 2 1 7 7 7 0 AAA domain IQ PF00612.27 VDK74209.1 - 0.72 9.8 4.3 2 8.4 0.7 2.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif TPR_19 PF14559.6 VDK74234.1 - 0.015 15.8 0.4 26 5.4 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK74234.1 - 0.043 14.0 5.3 0.81 10.1 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK74234.1 - 0.87 10.6 4.1 18 6.5 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat SR-25 PF10500.9 VDK74234.1 - 4.2 6.9 7.0 6.5 6.3 7.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HEAT PF02985.22 VDK74235.1 - 2.1e-06 27.5 22.3 0.0017 18.5 0.2 9.7 9 0 0 9 9 9 2 HEAT repeat HEAT_2 PF13646.6 VDK74235.1 - 2.6e-06 27.7 5.8 0.03 14.7 0.3 7.2 5 3 1 7 7 7 2 HEAT repeats HEAT_EZ PF13513.6 VDK74235.1 - 0.01 16.3 15.8 0.1 13.1 0.1 8.0 8 0 0 8 8 8 0 HEAT-like repeat Cnd1 PF12717.7 VDK74235.1 - 0.01 15.9 3.2 8.2 6.4 0.1 4.8 4 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Condensin2nSMC PF12422.8 VDK74235.1 - 0.039 14.2 2.3 6.6 6.9 0.1 3.3 3 0 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit RTP1_C1 PF10363.9 VDK74235.1 - 0.057 13.6 1.1 51 4.1 0.0 4.6 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 VDK74235.1 - 0.5 10.5 9.7 18 5.6 0.6 4.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Plasmod_dom_1 PF09715.10 VDK74237.1 - 0.055 13.5 0.3 0.88 9.7 0.0 2.6 2 0 0 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) Miga PF10265.9 VDK74239.1 - 0.19 10.6 3.4 0.26 10.2 3.4 1.2 1 0 0 1 1 1 0 Mitoguardin Macro PF01661.21 VDK74242.1 - 5.2e-40 136.2 0.3 7.3e-40 135.7 0.3 1.2 1 0 0 1 1 1 1 Macro domain BTB_2 PF02214.22 VDK74243.1 - 1.6e-23 82.9 0.0 3e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain WD40 PF00400.32 VDK74243.1 - 0.0085 16.9 3.2 0.98 10.4 0.1 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK74243.1 - 0.071 13.4 0.0 2.3 8.6 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain BTB_3 PF16017.5 VDK74243.1 - 0.075 13.1 0.0 0.23 11.6 0.0 1.8 1 0 0 1 1 1 0 BTB/POZ domain DnaJ PF00226.31 VDK74245.1 - 4.2e-20 71.6 0.1 1.1e-19 70.3 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 VDK74245.1 - 1.7e-06 27.8 0.0 2.9e-05 23.8 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) APG6_N PF17675.1 VDK74245.1 - 0.63 10.6 13.6 0.99 9.9 13.6 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region MtrG PF04210.13 VDK74246.1 - 0.17 11.7 0.1 0.46 10.4 0.1 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G v110 PF01639.17 VDK74246.1 - 7.1 6.6 14.2 0.061 13.2 5.2 2.2 3 0 0 3 3 3 0 Viral family 110 VPS9 PF02204.18 VDK74248.1 - 7.5e-09 35.8 0.0 7.8e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF2140 PF09911.9 VDK74248.1 - 0.044 13.3 0.0 0.055 13.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) Med26_C PF15693.5 VDK74249.1 - 3.3 7.8 8.0 4.9 7.3 1.2 2.4 2 0 0 2 2 2 0 Mediator complex subunit 26 C-terminal MORN PF02493.20 VDK74250.1 - 2.1e-14 52.4 40.7 0.0089 15.9 2.5 7.9 8 0 0 8 8 8 6 MORN repeat RCC1 PF00415.18 VDK74253.1 - 4.2e-18 65.7 0.0 5.2e-11 43.0 0.0 4.5 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 VDK74253.1 - 1.4e-13 50.2 13.7 3.9e-12 45.6 0.5 4.7 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 VDK74254.1 - 1.2e-77 260.7 0.0 1.4e-77 260.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK74254.1 - 6.8e-49 166.6 0.0 8e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 VDK74254.1 - 0.0012 17.7 0.1 0.0024 16.7 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 VDK74254.1 - 0.0066 16.1 0.1 0.021 14.5 0.1 1.7 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.14 VDK74254.1 - 0.0087 15.4 0.2 0.016 14.5 0.2 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF536 PF04394.14 VDK74278.1 - 0.036 13.9 0.2 0.042 13.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF536 CGI-121 PF08617.10 VDK74279.1 - 0.076 13.1 0.0 0.094 12.8 0.0 1.1 1 0 0 1 1 1 0 Kinase binding protein CGI-121 NMT1_2 PF13379.6 VDK74279.1 - 0.19 11.4 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 NMT1-like family CGI-121 PF08617.10 VDK74280.1 - 4.8e-29 101.6 0.5 5.7e-29 101.3 0.5 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 pP_pnuc_1 PF18165.1 VDK74280.1 - 0.021 14.7 0.3 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 Predicted pPIWI-associating nuclease FlaG PF03646.15 VDK74280.1 - 0.035 14.3 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 FlaG protein His_Phos_2 PF00328.22 VDK74282.1 - 2.9e-30 105.9 0.0 7.3e-30 104.6 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Ctr PF04145.15 VDK74283.1 - 6.4e-26 91.7 9.9 8.6e-26 91.3 9.9 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Multi_Drug_Res PF00893.19 VDK74283.1 - 0.015 15.9 1.0 0.015 15.9 1.0 2.0 2 0 0 2 2 2 0 Small Multidrug Resistance protein DUF2897 PF11446.8 VDK74283.1 - 0.056 13.3 0.4 0.12 12.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) DUF3619 PF12279.8 VDK74283.1 - 0.14 12.5 0.3 0.27 11.6 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3619) DUF4191 PF13829.6 VDK74283.1 - 8 5.7 5.6 1.3 8.3 1.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Dynein_light PF01221.18 VDK74284.1 - 1.9e-20 73.0 0.5 2.7e-20 72.5 0.5 1.2 1 0 0 1 1 1 1 Dynein light chain type 1 DUF29 PF01724.16 VDK74284.1 - 0.026 14.8 0.1 0.03 14.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF29 CIAPIN1 PF05093.13 VDK74284.1 - 0.096 13.2 0.1 0.11 13.0 0.1 1.2 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Sugar_tr PF00083.24 VDK74285.1 - 2.8e-40 138.6 18.2 3.9e-40 138.1 18.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK74285.1 - 1.3e-15 57.2 23.7 1.3e-15 57.2 23.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LYRIC PF15686.5 VDK74285.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family Glyco_transf_43 PF03360.16 VDK74286.1 - 2.2e-48 164.8 0.1 3.6e-48 164.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 43 ANAPC4_WD40 PF12894.7 VDK74286.1 - 7.4e-09 35.8 0.1 0.056 13.8 0.1 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK74286.1 - 2.2e-07 31.5 8.4 0.006 17.4 3.6 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat eIF2A PF08662.11 VDK74286.1 - 4.2e-06 26.8 0.0 0.0019 18.1 0.0 2.7 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Transp_cyt_pur PF02133.15 VDK74286.1 - 0.12 11.1 0.0 0.25 10.0 0.0 1.4 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin PQQ_3 PF13570.6 VDK74286.1 - 0.16 12.5 0.2 63 4.2 0.0 3.8 3 0 0 3 3 3 0 PQQ-like domain 7tm_1 PF00001.21 VDK74287.1 - 1.2e-11 44.4 10.2 1.2e-11 44.4 10.2 2.6 2 1 1 3 3 3 2 7 transmembrane receptor (rhodopsin family) zf-RING_2 PF13639.6 VDK74288.1 - 2e-11 44.1 11.9 3.5e-11 43.3 11.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK74288.1 - 4.2e-10 39.3 9.8 7.8e-10 38.4 9.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK74288.1 - 2.9e-08 33.9 9.3 9.2e-08 32.3 9.3 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 VDK74288.1 - 2.7e-06 27.1 9.0 5.9e-06 26.1 9.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK74288.1 - 2.6e-05 24.1 3.4 2.6e-05 24.1 3.4 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 VDK74288.1 - 0.00012 22.0 4.2 0.00022 21.2 4.2 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 VDK74288.1 - 0.00022 21.1 8.4 0.00044 20.2 8.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 VDK74288.1 - 0.00032 20.4 5.9 0.00094 18.9 5.9 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 VDK74288.1 - 0.00034 20.4 8.3 0.00054 19.8 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK74288.1 - 0.0048 16.7 5.5 0.059 13.2 5.5 2.2 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 VDK74288.1 - 0.007 16.0 8.1 0.014 15.0 8.1 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RAG1_imp_bd PF12560.8 VDK74288.1 - 0.011 15.3 2.2 0.011 15.3 2.2 2.0 2 0 0 2 2 2 0 RAG1 importin binding zf-RING-like PF08746.11 VDK74288.1 - 0.016 15.5 8.7 0.032 14.5 8.7 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_4 PF15227.6 VDK74288.1 - 0.019 15.1 7.8 0.05 13.8 7.8 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SlyX PF04102.12 VDK74288.1 - 0.022 15.4 5.4 0.022 15.4 5.4 3.1 3 1 1 4 4 3 0 SlyX zf-Nse PF11789.8 VDK74288.1 - 0.031 14.1 1.7 0.078 12.8 1.7 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn-ribbon_8 PF09723.10 VDK74288.1 - 0.042 14.0 1.0 0.16 12.1 1.0 2.0 1 0 0 1 1 1 0 Zinc ribbon domain SPT16 PF08644.11 VDK74288.1 - 0.096 12.9 9.1 0.56 10.4 4.0 2.1 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) CortBP2 PF09727.9 VDK74288.1 - 0.19 11.6 10.4 0.39 10.6 10.4 1.5 1 1 0 1 1 1 0 Cortactin-binding protein-2 FANCL_C PF11793.8 VDK74288.1 - 0.24 11.6 9.5 0.86 9.8 8.6 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 VDK74288.1 - 1.8 8.7 9.8 5.2 7.3 9.8 1.8 1 1 0 1 1 1 0 RING-variant domain zf-P11 PF03854.14 VDK74288.1 - 2.6 7.8 10.2 7 6.4 10.2 1.7 1 1 0 1 1 1 0 P-11 zinc finger zf-HC5HC2H PF13771.6 VDK74288.1 - 7.5 6.9 11.5 4.7 7.5 7.4 2.6 2 1 1 3 3 3 0 PHD-like zinc-binding domain zf-RING_4 PF14570.6 VDK74288.1 - 7.8 6.4 8.5 37 4.2 8.5 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Fib_alpha PF08702.10 VDK74288.1 - 8.4 6.6 10.6 9.5 6.4 0.6 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family BSMAP PF12280.8 VDK74289.1 - 1.2e-11 45.1 18.4 6.3e-11 42.8 4.7 3.0 1 1 1 2 2 2 2 Brain specific membrane anchored protein Vicilin_N PF04702.12 VDK74289.1 - 7.5 6.4 10.0 27 4.6 10.2 1.7 1 1 0 1 1 1 0 Vicilin N terminal region Kri1_C PF12936.7 VDK74290.1 - 2.7e-26 91.6 2.5 2.7e-26 91.6 2.5 4.3 4 0 0 4 4 4 1 KRI1-like family C-terminal Kri1 PF05178.12 VDK74290.1 - 4.4e-21 75.4 11.3 4.4e-21 75.4 11.3 5.3 5 3 1 6 6 6 1 KRI1-like family HeLo PF14479.6 VDK74290.1 - 7.7 6.3 9.8 1.3 8.8 0.6 2.7 2 0 0 2 2 2 0 Prion-inhibition and propagation Piwi PF02171.17 VDK74291.1 - 7.9e-65 219.1 0.0 1.1e-64 218.5 0.0 1.2 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 VDK74291.1 - 5.4e-11 42.5 0.1 1.6e-10 41.0 0.0 1.7 2 0 0 2 2 2 1 PAZ domain ArgoMid PF16487.5 VDK74291.1 - 3.7e-05 23.9 0.1 0.00027 21.1 0.0 2.4 2 0 0 2 2 2 1 Mid domain of argonaute Nup192 PF11894.8 VDK74292.1 - 3.5e-101 339.4 50.8 1.4e-100 337.5 50.8 1.8 1 1 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 GATA PF00320.27 VDK74293.1 - 3.4e-09 36.1 3.3 7.9e-09 35.0 3.3 1.7 1 0 0 1 1 1 1 GATA zinc finger ELM2 PF01448.24 VDK74293.1 - 3.8e-05 24.4 0.1 0.00015 22.5 0.1 2.1 1 0 0 1 1 1 1 ELM2 domain TFIIA_gamma_N PF02268.16 VDK74305.1 - 3.1e-20 71.9 0.1 5.9e-20 71.0 0.1 1.5 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 VDK74305.1 - 1.2e-17 63.8 2.7 1.2e-17 63.8 2.7 1.9 2 0 0 2 2 2 1 Transcription initiation factor IIA, gamma subunit ANAPC4_WD40 PF12894.7 VDK74305.1 - 7.8e-07 29.3 0.1 0.57 10.5 0.0 3.8 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK74305.1 - 1.2e-05 24.8 0.3 0.0011 18.4 0.0 2.8 1 1 1 3 3 3 1 WD40-like domain WD40 PF00400.32 VDK74305.1 - 0.00016 22.4 11.1 7.7 7.6 0.0 6.4 7 0 0 7 7 7 2 WD domain, G-beta repeat EPL1 PF10513.9 VDK74307.1 - 6.2e-09 36.4 1.3 1.3e-08 35.4 0.0 2.2 2 1 0 2 2 2 1 Enhancer of polycomb-like Gcd10p PF04189.13 VDK74308.1 - 4.9e-48 163.8 0.0 7.8e-48 163.1 0.0 1.3 1 1 0 1 1 1 1 Gcd10p family NatB_MDM20 PF09797.9 VDK74310.1 - 1e-75 255.1 3.0 1.1e-75 255.0 0.7 2.0 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_14 PF13428.6 VDK74310.1 - 0.0018 18.9 2.5 30 5.8 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat USP8_interact PF08941.10 VDK74310.1 - 0.012 15.5 0.3 0.029 14.2 0.3 1.6 1 0 0 1 1 1 0 USP8 interacting BTAD PF03704.17 VDK74310.1 - 0.18 12.2 0.8 0.93 9.9 0.7 2.3 2 1 0 2 2 2 0 Bacterial transcriptional activator domain DUF4988 PF16378.5 VDK74314.1 - 0.0028 17.4 1.4 0.0033 17.1 1.1 1.3 1 1 0 1 1 1 1 Domain of unknown function RecG_N PF17190.4 VDK74314.1 - 0.04 14.6 2.9 0.044 14.5 0.4 1.9 1 1 1 2 2 2 0 RecG N-terminal helical domain DASH_Dad4 PF08650.10 VDK74314.1 - 0.07 13.1 4.9 0.064 13.2 2.7 1.8 1 1 1 2 2 2 0 DASH complex subunit Dad4 HTH_7 PF02796.15 VDK74314.1 - 0.12 12.5 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase DUF1296 PF06972.11 VDK74314.1 - 0.14 12.4 1.0 0.88 9.8 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1296) Spt4 PF06093.13 VDK74317.1 - 2.5e-25 88.3 2.2 2.8e-25 88.2 2.2 1.0 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger ARS2 PF04959.13 VDK74319.1 - 7.2e-51 173.4 0.0 7.2e-51 173.4 0.0 2.1 2 0 0 2 2 2 1 Arsenite-resistance protein 2 DUF3546 PF12066.8 VDK74319.1 - 2.5e-38 130.7 2.3 2.5e-38 130.7 2.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) zf-C2H2_aberr PF17017.5 VDK74319.1 - 0.19 11.8 1.7 15 5.7 0.0 2.6 2 0 0 2 2 2 0 Aberrant zinc-finger RhlB PF12300.8 VDK74319.1 - 2.9 8.0 21.9 0.25 11.5 4.5 2.3 2 0 0 2 2 2 0 ATP-dependent RNA helicase RhlB zf-RING_9 PF13901.6 VDK74320.1 - 7.8e-66 222.0 35.6 4.5e-65 219.5 15.6 2.7 3 0 0 3 3 3 2 Putative zinc-RING and/or ribbon C1_1 PF00130.22 VDK74320.1 - 4.2e-07 29.7 3.4 4.2e-07 29.7 3.4 4.4 3 1 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Thioredoxin_7 PF13899.6 VDK74320.1 - 0.19 11.9 0.9 0.55 10.5 0.1 2.2 1 1 1 2 2 2 0 Thioredoxin-like Zn_Tnp_IS1595 PF12760.7 VDK74320.1 - 0.71 9.9 25.7 3.4 7.7 2.1 4.9 4 0 0 4 4 4 0 Transposase zinc-ribbon domain HSP70 PF00012.20 VDK74320.1 - 1.1 7.3 5.1 1.6 6.8 5.1 1.1 1 0 0 1 1 1 0 Hsp70 protein Ras PF00071.22 VDK74321.1 - 3.9e-48 163.1 0.1 5.7e-48 162.6 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK74321.1 - 7e-30 103.7 0.0 1.8e-29 102.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK74321.1 - 1.9e-12 47.0 0.0 2.8e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK74321.1 - 7.1e-09 35.4 0.0 1.2e-08 34.6 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 VDK74321.1 - 1.6e-05 24.4 0.0 2.8e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 VDK74321.1 - 2.4e-05 24.4 0.0 5.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 VDK74321.1 - 8.9e-05 21.8 1.7 0.0046 16.2 0.9 3.1 1 1 2 3 3 3 1 G-protein alpha subunit ATP_bind_1 PF03029.17 VDK74321.1 - 0.0014 18.5 2.7 0.0023 17.8 0.5 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 VDK74321.1 - 0.06 13.2 0.3 7.9 6.4 0.1 2.5 1 1 1 2 2 2 0 RsgA GTPase DUF3873 PF12989.7 VDK74321.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) Peptidase_M1_N PF17900.1 VDK74322.1 - 5.8e-26 91.8 0.1 1.1e-25 90.9 0.1 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 VDK74322.1 - 2.7e-25 89.2 0.1 4.9e-25 88.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain DUF2808 PF10989.8 VDK74322.1 - 0.048 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) MFS_MOT1 PF16983.5 VDK74322.1 - 0.059 13.8 0.1 0.14 12.6 0.1 1.6 1 0 0 1 1 1 0 Molybdate transporter of MFS superfamily Synaptobrevin PF00957.21 VDK74322.1 - 8.9 6.2 6.9 0.47 10.3 1.1 1.9 2 0 0 2 2 2 0 Synaptobrevin RPA_interact_C PF14768.6 VDK74326.1 - 4.1e-10 40.1 5.5 4.1e-10 40.1 5.5 1.9 2 0 0 2 2 2 1 Replication protein A interacting C-terminal RPA_interact_N PF14766.6 VDK74326.1 - 2.3e-09 36.8 3.4 3.7e-09 36.1 3.4 1.4 1 0 0 1 1 1 1 Replication protein A interacting N-terminal zf-FPG_IleRS PF06827.14 VDK74326.1 - 0.028 14.3 0.1 0.028 14.3 0.1 2.6 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS zinc_ribbon_4 PF13717.6 VDK74326.1 - 0.038 13.9 2.5 29 4.7 0.3 3.4 3 0 0 3 3 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 VDK74326.1 - 0.051 13.5 2.3 0.14 12.1 0.3 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DUF3135 PF11333.8 VDK74326.1 - 0.067 13.5 1.1 0.14 12.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Zn_Tnp_IS91 PF14319.6 VDK74326.1 - 0.08 13.0 0.1 0.08 13.0 0.1 2.4 3 1 0 3 3 3 0 Transposase zinc-binding domain PriA_CRR PF18319.1 VDK74326.1 - 0.11 12.5 5.4 0.62 10.1 2.8 2.8 2 1 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain eIF-5_eIF-2B PF01873.17 VDK74326.1 - 0.7 9.8 8.3 1.5 8.7 0.5 3.0 2 1 1 3 3 3 0 Domain found in IF2B/IF5 Zn_ribbon_SprT PF17283.2 VDK74326.1 - 1.5 8.8 8.9 0.31 11.0 1.5 2.8 3 0 0 3 3 3 0 SprT-like zinc ribbon domain Neur_chan_LBD PF02931.23 VDK74327.1 - 3.5e-34 118.1 0.0 5.1e-34 117.6 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK74327.1 - 1.1e-29 104.1 7.5 4.1e-28 99.1 2.9 2.1 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Monooxygenase_B PF04744.12 VDK74327.1 - 0.12 11.2 0.1 0.16 10.8 0.1 1.3 1 0 0 1 1 1 0 Monooxygenase subunit B protein Acyl-CoA_dh_1 PF00441.24 VDK74329.1 - 1.3e-35 122.8 1.1 1.7e-34 119.2 1.1 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 VDK74329.1 - 1.4e-22 80.5 0.0 2.5e-22 79.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 VDK74329.1 - 6.8e-19 67.9 0.0 1.2e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 VDK74329.1 - 4.2e-10 40.0 0.0 9.4e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain CLP1_P PF16575.5 VDK74330.1 - 2.8e-71 239.2 0.0 1.8e-70 236.6 0.0 2.0 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 VDK74330.1 - 1.5e-28 98.8 0.1 2.6e-28 98.1 0.1 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 VDK74330.1 - 1.7e-27 96.2 0.1 2.6e-27 95.6 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 TniB PF05621.11 VDK74330.1 - 0.00067 19.1 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein AAA_24 PF13479.6 VDK74330.1 - 0.0026 17.5 0.0 0.0082 15.9 0.0 1.9 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 VDK74330.1 - 0.0043 17.1 0.0 0.013 15.5 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 VDK74330.1 - 0.011 15.5 0.1 0.024 14.4 0.1 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein CbiA PF01656.23 VDK74330.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 VDK74330.1 - 0.02 14.5 0.2 0.31 10.6 0.0 2.6 2 1 1 3 3 3 0 SRP54-type protein, GTPase domain AAA PF00004.29 VDK74330.1 - 0.063 13.7 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK74330.1 - 0.074 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 VDK74330.1 - 0.087 13.2 0.0 0.14 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain CK2S PF15011.6 VDK74331.1 - 0.017 15.0 6.3 0.092 12.6 4.3 2.6 2 1 0 2 2 2 0 Casein Kinase 2 substrate FlaC_arch PF05377.11 VDK74331.1 - 0.2 12.1 3.9 0.48 10.9 2.1 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) UFD1 PF03152.14 VDK74351.1 - 0.02 14.3 0.0 3.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin fusion degradation protein UFD1 Isochorismatase PF00857.20 VDK74353.1 - 1.5e-29 103.4 0.3 2.2e-29 102.9 0.3 1.2 1 0 0 1 1 1 1 Isochorismatase family HSP90 PF00183.18 VDK74355.1 - 1.7e-233 776.2 36.6 2.2e-233 775.8 36.6 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 VDK74355.1 - 6.4e-14 52.4 0.0 1.8e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 VDK74355.1 - 1.9e-11 43.9 0.1 5.5e-11 42.5 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TRAP_alpha PF03896.16 VDK74355.1 - 0.016 14.4 7.6 0.037 13.2 7.6 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit pP_pnuc_1 PF18165.1 VDK74355.1 - 0.12 12.3 3.5 1.9 8.4 0.4 2.8 2 0 0 2 2 2 0 Predicted pPIWI-associating nuclease Zip PF02535.22 VDK74355.1 - 0.57 9.3 1.4 0.94 8.6 1.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 VDK74355.1 - 2.6 8.5 7.1 5.5 7.4 7.1 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 TTL PF03133.15 VDK74356.1 - 1.8e-85 286.6 0.0 3e-85 285.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 VDK74356.1 - 9.7e-07 28.3 0.0 0.0001 21.6 0.0 2.5 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 VDK74356.1 - 1.4e-06 27.8 0.0 0.032 13.5 0.0 2.3 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp AAA_11 PF13086.6 VDK74356.1 - 0.036 13.9 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain PH PF00169.29 VDK74357.1 - 0.00023 21.6 0.1 0.00052 20.5 0.1 1.7 1 0 0 1 1 1 1 PH domain PI-PLC-X PF00388.19 VDK74360.1 - 4.4e-60 201.5 0.0 1.1e-59 200.2 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 VDK74360.1 - 1.8e-43 147.6 0.1 1.8e-43 147.6 0.1 2.7 3 0 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_14 PF17787.1 VDK74360.1 - 1.8e-27 95.8 0.0 4.3e-27 94.6 0.0 1.7 1 0 0 1 1 1 1 PH domain DUF1154 PF06631.11 VDK74360.1 - 3.5e-15 55.7 13.4 1.3e-14 53.9 13.4 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1154) EF-hand_like PF09279.11 VDK74360.1 - 1e-10 41.9 0.1 1e-10 41.9 0.1 4.3 4 0 0 4 4 4 1 Phosphoinositide-specific phospholipase C, efhand-like CobN-Mg_chel PF02514.16 VDK74360.1 - 1.1 6.9 12.7 1.7 6.3 12.7 1.3 1 0 0 1 1 1 0 CobN/Magnesium Chelatase IF4E PF01652.18 VDK74363.1 - 2.1e-55 186.9 0.9 2.7e-55 186.5 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E UCH PF00443.29 VDK74365.1 - 1.5e-51 175.4 2.7 3.3e-51 174.3 1.9 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 VDK74365.1 - 1.5e-28 99.3 1.0 1.5e-28 99.3 1.0 1.9 2 0 0 2 2 2 1 USP8 dimerisation domain UCH_1 PF13423.6 VDK74365.1 - 6.9e-18 65.3 12.9 7e-18 65.3 8.9 2.7 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase TPPII_N PF12583.8 VDK74365.1 - 0.25 11.9 1.7 0.42 11.2 0.1 2.0 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal PH PF00169.29 VDK74365.1 - 0.86 10.1 3.1 0.66 10.5 0.4 2.3 2 0 0 2 2 2 0 PH domain TGT PF01702.18 VDK74370.1 - 2.8e-39 135.3 0.0 8.5e-34 117.2 0.0 2.2 2 0 0 2 2 2 2 Queuine tRNA-ribosyltransferase DUF2315 PF10231.9 VDK74370.1 - 2.5e-36 124.5 7.3 2.5e-36 124.5 7.3 1.8 2 0 0 2 2 2 1 Apoptogenic protein 1 Spore_III_AB PF09548.10 VDK74370.1 - 3.9 7.6 5.3 9.2 6.3 5.3 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) MEA1 PF06910.11 VDK74371.1 - 6.7e-08 33.2 1.5 1.6e-07 32.0 1.5 1.8 1 1 0 1 1 1 1 Male enhanced antigen 1 (MEA1) Melibiase_2 PF16499.5 VDK74372.1 - 1.6e-132 440.9 6.4 2e-132 440.7 6.4 1.0 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 VDK74372.1 - 2.7e-09 37.0 0.0 1e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 VDK74372.1 - 4.1e-06 26.0 0.0 7.4e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Melibiase Melibiase_2_C PF17450.2 VDK74372.1 - 8.7e-05 22.7 0.0 0.00017 21.8 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain HSP70 PF00012.20 VDK74373.1 - 1.1e-270 899.1 15.1 1.7e-270 898.4 15.1 1.3 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 VDK74373.1 - 6.5e-16 58.1 1.5 2.8e-13 49.4 0.2 2.8 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 VDK74373.1 - 3.4e-05 23.7 0.1 0.0005 19.9 0.1 2.4 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 VDK74373.1 - 0.00023 21.6 2.7 0.53 10.7 0.0 3.8 3 1 0 3 3 3 2 Cell division protein FtsA Tn7_Tnp_TnsA_C PF08721.11 VDK74373.1 - 0.066 13.9 0.3 0.19 12.4 0.3 1.8 1 0 0 1 1 1 0 TnsA endonuclease C terminal FGGY_N PF00370.21 VDK74373.1 - 5.7 6.4 6.5 1.7 8.1 0.1 2.5 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain Palm_thioest PF02089.15 VDK74374.1 - 4e-84 282.2 0.0 4.7e-84 282.0 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 VDK74374.1 - 0.0067 16.1 0.0 0.14 11.8 0.0 2.3 1 1 0 2 2 2 1 alpha/beta hydrolase fold DUF676 PF05057.14 VDK74374.1 - 0.039 13.4 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) NAD_binding_1 PF00175.21 VDK74374.1 - 0.092 13.4 0.0 0.25 12.0 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain Sugar_tr PF00083.24 VDK74375.1 - 5.3e-29 101.4 18.9 9.2e-29 100.6 18.9 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK74375.1 - 1.3e-16 60.5 22.7 2.8e-11 43.0 17.2 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily tRNA_int_endo PF01974.17 VDK74395.1 - 8.7e-13 48.2 0.9 1.3e-12 47.6 0.9 1.2 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 VDK74395.1 - 0.0017 17.9 0.0 0.0028 17.3 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain IPU_b_solenoid PF18783.1 VDK74396.1 - 2 8.5 10.0 2.6 8.1 1.1 3.0 3 0 0 3 3 3 0 Isopullulanase beta-solenoid repeat DUF1002 PF06207.11 VDK74398.1 - 0.02 14.4 2.4 0.032 13.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) DUF5470 PF17564.2 VDK74398.1 - 0.033 14.4 0.9 0.092 13.0 0.9 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5470) MtmB PF05369.12 VDK74398.1 - 0.074 11.8 0.0 0.096 11.5 0.0 1.2 1 0 0 1 1 1 0 Monomethylamine methyltransferase MtmB I-set PF07679.16 VDK74400.1 - 5.5e-107 350.1 0.1 1.8e-21 76.0 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK74400.1 - 5.2e-69 228.8 0.1 1.9e-11 44.4 0.0 6.6 6 0 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.6 VDK74400.1 - 1.1e-33 115.4 0.0 9.2e-06 25.9 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 VDK74400.1 - 5.6e-24 84.1 0.0 0.0036 17.4 0.0 6.6 6 0 0 6 6 6 5 Immunoglobulin domain V-set PF07686.17 VDK74400.1 - 5.4e-12 45.9 0.5 0.059 13.5 0.0 7.6 7 2 2 9 9 8 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK74400.1 - 3.4e-08 33.5 0.0 5.8 7.1 0.0 6.6 6 0 0 6 6 6 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 VDK74400.1 - 5.3e-08 33.0 0.2 0.0095 16.1 0.0 4.9 4 1 1 5 5 5 2 Natural killer cell receptor 2B4 Ig_5 PF16681.5 VDK74400.1 - 0.00012 22.5 0.0 4 7.9 0.0 5.6 5 0 0 5 5 5 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Spectrin PF00435.21 VDK74400.1 - 0.00026 21.4 5.0 0.0016 18.9 0.8 9.6 5 3 3 8 8 8 2 Spectrin repeat Ig_6 PF18452.1 VDK74400.1 - 0.00033 20.1 0.0 0.059 12.9 0.0 3.8 5 0 0 5 5 5 1 Immunoglobulin domain DUF4198 PF10670.9 VDK74400.1 - 0.0013 19.1 0.1 0.024 15.0 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4198) Izumo-Ig PF16706.5 VDK74400.1 - 0.0015 18.5 1.1 19 5.4 0.0 5.6 7 1 0 7 7 6 0 Izumo-like Immunoglobulin domain Herpes_gE PF02480.16 VDK74400.1 - 0.0078 15.0 0.1 1.1 8.0 0.0 3.4 5 0 0 5 5 5 1 Alphaherpesvirus glycoprotein E Spin-Ssty PF02513.17 VDK74401.1 - 0.017 14.9 0.0 0.97 9.2 0.0 2.3 2 0 0 2 2 2 0 Spin/Ssty Family FKBP_C PF00254.28 VDK74402.1 - 2.7e-41 139.8 0.0 6.3e-32 109.8 0.0 2.4 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 VDK74402.1 - 3e-15 55.3 8.1 4e-06 26.4 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 VDK74402.1 - 1.1e-11 43.9 4.8 2e-05 24.3 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK74402.1 - 2.1e-08 33.7 0.8 0.0017 18.0 0.8 3.6 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 VDK74402.1 - 9.9e-08 31.6 3.4 0.00055 20.0 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK74402.1 - 3.7e-06 27.1 3.4 0.069 13.4 0.3 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 VDK74402.1 - 4.5e-06 27.0 1.9 0.0012 19.4 0.2 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK74402.1 - 9.4e-05 23.0 0.4 0.052 14.2 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK74402.1 - 0.00033 21.1 2.7 0.00061 20.2 2.1 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK74402.1 - 0.00067 19.8 0.7 0.015 15.4 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 VDK74402.1 - 0.0011 19.2 1.4 0.073 13.5 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK74402.1 - 0.0039 17.9 0.1 0.15 13.0 0.4 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK74402.1 - 0.0086 16.3 1.5 0.016 15.4 1.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 VDK74402.1 - 0.033 14.2 0.4 1.7 8.8 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat GOLD_2 PF13897.6 VDK74405.1 - 1.6e-69 232.7 2.5 2e-69 232.4 2.5 1.1 1 0 0 1 1 1 1 Golgi-dynamics membrane-trafficking F-box PF00646.33 VDK74406.1 - 5.9e-05 22.8 0.1 0.00016 21.4 0.1 1.8 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 VDK74406.1 - 0.00081 19.2 10.2 0.3 11.2 0.2 6.8 8 0 0 8 8 8 1 Leucine Rich repeat F-box-like PF12937.7 VDK74406.1 - 0.0014 18.4 2.6 0.0033 17.3 0.2 2.4 2 0 0 2 2 2 1 F-box-like LRR_8 PF13855.6 VDK74406.1 - 0.0014 18.3 3.9 8.5 6.2 0.1 5.0 5 1 0 5 5 5 2 Leucine rich repeat LRR_4 PF12799.7 VDK74406.1 - 0.016 15.6 18.3 0.36 11.3 0.0 6.8 5 2 2 7 7 7 0 Leucine Rich repeats (2 copies) ACBP PF00887.19 VDK74407.1 - 2.6e-12 46.8 0.0 3.2e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 Acyl CoA binding protein TFIID_30kDa PF03540.13 VDK74408.1 - 3e-24 84.7 0.8 1.6e-22 79.1 0.3 2.9 2 0 0 2 2 2 2 Transcription initiation factor TFIID 23-30kDa subunit FERM_C PF09380.10 VDK74410.1 - 5.1e-11 42.8 0.0 1.2e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 VDK74410.1 - 8.3e-10 39.1 0.0 3.1e-09 37.3 0.0 2.0 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 VDK74410.1 - 0.00014 21.8 0.0 0.00058 19.8 0.0 2.0 2 0 0 2 2 2 1 FERM N-terminal domain NPA PF16469.5 VDK74411.1 - 2.7e-63 212.0 32.2 1.5e-23 83.7 7.8 4.1 4 0 0 4 4 4 3 Nematode polyprotein allergen ABA-1 HTH_38 PF13936.6 VDK74411.1 - 0.0039 16.9 0.8 9.1 6.1 0.0 3.6 3 0 0 3 3 3 2 Helix-turn-helix domain HTH_Tnp_Tc3_1 PF11427.8 VDK74411.1 - 0.03 14.2 1.2 3.4 7.6 0.0 3.7 4 0 0 4 4 4 0 Tc3 transposase TetR_C_6 PF13977.6 VDK74411.1 - 0.084 13.1 0.2 0.67 10.2 0.0 2.4 2 0 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal DAGK_prokar PF01219.19 VDK74411.1 - 0.19 11.6 0.0 0.5 10.2 0.0 1.7 1 0 0 1 1 1 0 Prokaryotic diacylglycerol kinase DUF4473 PF14747.6 VDK74411.1 - 0.35 11.5 6.0 14 6.3 0.2 4.5 2 1 3 5 5 5 0 Domain of unknown function (DUF4473) SieB PF14163.6 VDK74411.1 - 0.87 9.1 5.2 5.1 6.6 0.2 3.1 3 0 0 3 3 3 0 Super-infection exclusion protein B Cnd1 PF12717.7 VDK74411.1 - 1.5 8.9 5.3 3.6 7.6 2.8 2.6 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DnaG_DnaB_bind PF08278.11 VDK74411.1 - 3 8.4 9.0 5.1 7.7 1.6 3.7 3 1 1 4 4 4 0 DNA primase DnaG DnaB-binding DUF2116 PF09889.9 VDK74434.1 - 0.012 15.6 0.1 0.029 14.3 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MMM1 PF10296.9 VDK74434.1 - 0.022 13.8 0.2 2 7.4 0.0 2.9 2 1 1 3 3 3 0 Maintenance of mitochondrial morphology protein 1 PH PF00169.29 VDK74434.1 - 0.096 13.2 0.3 0.36 11.4 0.3 2.0 1 0 0 1 1 1 0 PH domain AbiEi_3 PF11459.8 VDK74434.1 - 0.099 12.3 0.0 0.38 10.4 0.0 1.9 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system Ribosomal_L27 PF01016.19 VDK74436.1 - 6.5e-06 26.1 0.0 9.4e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein TPR_12 PF13424.6 VDK74437.1 - 4.6e-19 68.5 5.8 2.2e-08 34.2 0.4 4.3 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 VDK74437.1 - 9.4e-13 47.2 9.3 0.0072 16.4 0.1 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 VDK74437.1 - 1.5e-12 46.9 14.0 0.0023 17.8 0.1 5.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 VDK74437.1 - 5.7e-12 44.9 10.7 0.09 13.0 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK74437.1 - 5.9e-10 39.0 0.2 9.1e-06 25.3 0.1 2.3 2 1 0 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 VDK74437.1 - 2.7e-08 33.9 1.0 0.24 12.3 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK74437.1 - 4.6e-08 32.6 13.3 0.0046 16.7 0.2 5.5 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK74437.1 - 5.5e-07 30.0 4.8 5.3e-05 23.7 0.4 3.8 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 VDK74437.1 - 4.7e-05 23.5 3.8 4.3 7.9 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK74437.1 - 5.7e-05 23.7 1.4 0.27 11.9 0.0 4.2 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 VDK74437.1 - 8.8e-05 22.9 6.0 0.16 12.6 0.1 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat FAT PF02259.23 VDK74437.1 - 0.0011 18.3 1.1 0.13 11.4 0.1 2.7 3 0 0 3 3 3 1 FAT domain TPR_7 PF13176.6 VDK74437.1 - 0.0022 17.9 5.4 2.1 8.5 0.0 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat RPN7 PF10602.9 VDK74437.1 - 0.0025 17.5 1.6 0.0025 17.5 1.6 2.1 2 0 0 2 2 2 1 26S proteasome subunit RPN7 TPR_3 PF07720.12 VDK74437.1 - 0.0034 17.3 2.2 0.2 11.7 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 VDK74437.1 - 0.0057 15.9 0.4 0.066 12.4 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK74437.1 - 0.0061 16.2 5.5 3.5 7.4 0.0 3.9 4 0 0 4 4 4 2 TPR repeat SNAP PF14938.6 VDK74437.1 - 0.015 14.8 0.8 0.029 13.8 0.8 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 VDK74437.1 - 0.023 14.9 4.8 0.039 14.2 0.2 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MINDY_DUB PF04424.13 VDK74437.1 - 0.043 13.8 0.1 0.094 12.7 0.1 1.6 1 0 0 1 1 1 0 MINDY deubiquitinase ANAPC5 PF12862.7 VDK74437.1 - 0.068 13.2 0.2 0.58 10.2 0.0 2.5 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 Fe-S_biosyn PF01521.20 VDK74438.1 - 1.5e-17 63.8 0.0 1.8e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis CENP-Q PF13094.6 VDK74440.1 - 0.02 15.1 0.0 0.024 14.8 0.0 1.1 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PDZ PF00595.24 VDK74441.1 - 0.00021 21.6 0.0 0.00028 21.2 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK74441.1 - 0.00054 19.8 0.1 0.00086 19.1 0.1 1.3 1 0 0 1 1 1 1 PDZ domain CREPT PF16566.5 VDK74441.1 - 0.055 13.6 0.1 0.061 13.5 0.1 1.1 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour AAA_lid_9 PF17871.1 VDK74441.1 - 0.074 13.0 0.0 0.092 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA lid domain L27 PF02828.16 VDK74443.1 - 2.6e-14 52.7 0.0 3.4e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 L27 domain PDZ PF00595.24 VDK74443.1 - 8.8e-12 45.2 0.6 1.4e-11 44.6 0.6 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK74443.1 - 0.00011 21.9 0.1 0.0003 20.6 0.1 1.7 1 0 0 1 1 1 1 PDZ domain BsuBI_PstI_RE PF06616.11 VDK74443.1 - 0.081 12.2 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain His_Phos_2 PF00328.22 VDK74443.1 - 0.095 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) HECT PF00632.25 VDK74445.1 - 7e-77 258.9 0.0 1e-76 258.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 VDK74445.1 - 3.1e-06 26.5 1.3 7.9e-06 25.2 1.3 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif W2 PF02020.18 VDK74448.1 - 6.8e-17 61.4 0.8 1.5e-16 60.3 0.8 1.5 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 VDK74448.1 - 4.1e-06 26.3 8.5 0.034 13.9 1.9 3.6 2 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 VDK74448.1 - 0.00014 20.2 0.4 0.00025 19.4 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 VDK74448.1 - 0.0016 17.4 0.1 0.0029 16.6 0.1 1.4 1 0 0 1 1 1 1 L-fucokinase BSD PF03909.17 VDK74448.1 - 0.019 15.0 0.2 0.17 11.9 0.0 2.5 2 0 0 2 2 2 0 BSD domain Hexapep_2 PF14602.6 VDK74448.1 - 0.33 10.7 13.6 0.29 10.9 4.2 3.4 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase DUF1908 PF08926.11 VDK74451.1 - 3.5e-61 206.8 4.5 3.6e-41 141.1 0.1 3.9 5 0 0 5 5 5 2 Domain of unknown function (DUF1908) Pkinase PF00069.25 VDK74451.1 - 1.9e-60 204.4 0.0 4.5e-60 203.2 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74451.1 - 2.1e-27 96.1 0.0 4.8e-27 94.9 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase PDZ PF00595.24 VDK74451.1 - 2.4e-07 31.0 0.0 4.8e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK74451.1 - 8.9e-07 28.7 0.0 2.1e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Kinase-like PF14531.6 VDK74451.1 - 1e-05 25.0 0.0 9.8e-05 21.8 0.0 2.2 2 0 0 2 2 2 1 Kinase-like PDZ_2 PF13180.6 VDK74451.1 - 5.9e-05 23.3 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 PDZ domain APH PF01636.23 VDK74451.1 - 0.00061 19.8 0.1 0.042 13.8 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 VDK74451.1 - 0.016 14.2 0.1 0.016 14.2 0.1 2.0 2 0 0 2 2 2 0 Haspin like kinase domain SNase PF00565.17 VDK74453.1 - 0.017 15.6 0.1 0.089 13.3 0.0 2.3 2 1 0 2 2 2 0 Staphylococcal nuclease homologue Band_7 PF01145.25 VDK74454.1 - 3e-23 82.7 0.5 4.6e-23 82.1 0.5 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 VDK74454.1 - 0.013 14.6 0.2 0.018 14.1 0.2 1.1 1 0 0 1 1 1 0 SigmaW regulon antibacterial Med2 PF11214.8 VDK74454.1 - 0.076 13.2 0.3 0.15 12.2 0.3 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 DB PF01682.19 VDK74455.1 - 4.1e-19 68.7 12.6 6.7e-19 68.0 12.6 1.4 1 0 0 1 1 1 1 DB module DUF5621 PF18532.1 VDK74455.1 - 0.041 13.8 0.1 0.092 12.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5621) UQ_con PF00179.26 VDK74457.1 - 1.7e-47 160.6 0.0 1.9e-47 160.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme NAD_kinase PF01513.21 VDK74458.1 - 1.1e-14 54.4 0.0 1.6e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 VDK74458.1 - 0.0012 18.5 0.0 0.0097 15.5 0.0 2.1 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain DUF4960 PF16324.5 VDK74458.1 - 0.075 12.6 0.2 0.12 11.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4960) CDCA PF18484.1 VDK74458.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Cadmium carbonic anhydrase repeat ARID PF01388.21 VDK74461.1 - 9.4e-18 64.7 0.0 2.9e-17 63.1 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain RFX_DNA_binding PF02257.15 VDK74461.1 - 5.6e-06 26.9 0.1 2.1e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 RFX DNA-binding domain FOXP-CC PF16159.5 VDK74461.1 - 0.00059 20.4 11.2 0.22 12.1 4.4 2.9 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 VDK74461.1 - 0.048 13.8 1.6 0.093 12.9 0.3 2.2 2 1 1 3 3 3 0 Aberrant zinc-finger zf-Di19 PF05605.12 VDK74461.1 - 0.13 12.6 6.4 0.43 10.9 6.4 2.0 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF4175 PF13779.6 VDK74461.1 - 0.13 10.1 0.1 0.21 9.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Patched PF02460.18 VDK74463.1 - 4e-24 84.8 0.0 4.4e-24 84.6 0.0 1.0 1 0 0 1 1 1 1 Patched family hemP PF10636.9 VDK74463.1 - 0.15 11.9 0.0 0.42 10.5 0.0 1.8 1 0 0 1 1 1 0 Hemin uptake protein hemP Nup35_RRM_2 PF14605.6 VDK74492.1 - 8.5e-18 64.1 0.3 5e-14 52.0 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif PWI PF01480.17 VDK74492.1 - 4.6e-08 33.3 0.0 1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 PWI domain Nup35_RRM PF05172.13 VDK74492.1 - 0.00042 20.2 0.2 0.024 14.6 0.0 3.0 2 1 0 2 2 2 1 Nup53/35/40-type RNA recognition motif zf_CCCH_4 PF18345.1 VDK74492.1 - 0.0011 18.9 2.1 0.0019 18.2 2.1 1.4 1 0 0 1 1 1 1 Zinc finger domain RRM_1 PF00076.22 VDK74492.1 - 0.0023 17.7 0.1 0.13 12.1 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 VDK74492.1 - 0.0034 17.3 3.2 0.0054 16.6 3.2 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TMEM132 PF16070.5 VDK74498.1 - 9.1e-94 314.6 2.3 9.1e-94 314.6 2.3 1.7 2 0 0 2 2 2 1 Transmembrane protein family 132 HA2 PF04408.23 VDK74500.1 - 6.8e-24 84.2 0.3 2.1e-23 82.6 0.3 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 VDK74500.1 - 7.7e-22 77.5 0.0 3.1e-21 75.5 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 VDK74500.1 - 1.6e-11 44.5 0.0 4.1e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 VDK74500.1 - 1.5e-06 28.5 0.0 6.2e-06 26.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 VDK74500.1 - 4.4e-06 26.6 0.0 9.4e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 VDK74500.1 - 0.00072 19.9 0.1 0.0022 18.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 VDK74500.1 - 0.0017 18.4 0.0 0.35 10.9 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SRP54 PF00448.22 VDK74500.1 - 0.007 16.0 0.0 0.019 14.6 0.0 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain Flavi_DEAD PF07652.14 VDK74500.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_30 PF13604.6 VDK74500.1 - 0.12 12.0 0.0 0.28 10.9 0.0 1.5 1 1 1 2 2 2 0 AAA domain AAA_25 PF13481.6 VDK74500.1 - 0.12 11.9 0.0 0.26 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain NicO PF03824.16 VDK74502.1 - 2.9 7.2 13.1 3.5 6.9 13.1 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein HAD_2 PF13419.6 VDK74505.1 - 2.1e-17 63.8 0.0 2.8e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 VDK74505.1 - 2.5e-12 47.5 0.0 1.1e-07 32.4 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 VDK74505.1 - 0.00096 19.2 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 VDK74505.1 - 0.14 12.5 0.0 0.27 11.6 0.0 1.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase UCH PF00443.29 VDK74507.1 - 2.1e-31 109.4 0.0 2.6e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK74507.1 - 5.7e-10 39.3 0.0 1.1e-09 38.4 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Histone PF00125.24 VDK74508.1 - 7.6e-54 181.6 1.6 8.5e-54 181.4 1.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 VDK74508.1 - 7.9e-05 22.7 0.2 0.00017 21.7 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 VDK74508.1 - 0.00015 22.3 2.4 0.00019 22.0 2.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 VDK74508.1 - 0.00028 21.2 0.0 0.00042 20.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 VDK74508.1 - 0.054 13.8 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Metallophos_2 PF12850.7 VDK74509.1 - 8.1e-22 78.2 0.2 1e-21 77.9 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 VDK74509.1 - 9.3e-05 23.0 0.5 0.012 16.1 0.5 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Nsp2a_N PF17896.1 VDK74509.1 - 0.053 12.7 0.0 0.067 12.4 0.0 1.2 1 0 0 1 1 1 0 Replicase polyprotein 1a N-terminal domain Astacin PF01400.24 VDK74510.1 - 8e-33 113.7 0.0 9.4e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) TTR-52 PF01060.23 VDK74511.1 - 4.8e-10 40.0 0.0 5.5e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family UQ_con PF00179.26 VDK74514.1 - 4.1e-27 94.5 0.0 6.2e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme MIT_C PF16565.5 VDK74522.1 - 1e-45 155.2 0.1 1.4e-45 154.7 0.1 1.2 1 0 0 1 1 1 1 Phospholipase D-like domain at C-terminus of MIT MIT PF04212.18 VDK74522.1 - 2.3e-16 59.6 0.4 4.5e-16 58.7 0.4 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain PA28_beta PF02252.18 VDK74523.1 - 1.7e-59 199.7 0.4 2.3e-59 199.3 0.4 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 VDK74523.1 - 1.7e-11 44.0 0.3 3.7e-11 42.9 0.3 1.6 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit Glyco_hydro_38N PF01074.22 VDK74524.1 - 2.2e-56 191.4 3.4 2.6e-56 191.1 3.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain ANAPC2 PF08672.11 VDK74524.1 - 0.056 14.0 1.3 15 6.2 0.0 3.3 3 0 0 3 3 3 0 Anaphase promoting complex (APC) subunit 2 UQ_con PF00179.26 VDK74547.1 - 1.2e-41 141.7 0.0 1.7e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK74547.1 - 0.072 12.8 0.1 0.31 10.7 0.1 1.9 1 1 0 1 1 1 0 Prokaryotic E2 family B LSM PF01423.22 VDK74550.1 - 4.6e-20 71.1 0.1 5.7e-20 70.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 VDK74550.1 - 4.4e-06 26.7 0.0 5.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 VDK74550.1 - 0.0065 16.6 0.1 0.0083 16.2 0.1 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain Cation_ATPase_C PF00689.21 VDK74553.1 - 1.3e-43 148.9 2.3 1.3e-43 148.9 2.3 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 VDK74553.1 - 3.3e-32 111.5 9.7 4.3e-16 59.0 0.0 3.5 3 1 1 4 4 4 2 E1-E2 ATPase Hydrolase PF00702.26 VDK74553.1 - 2e-17 64.2 0.1 1.8e-13 51.3 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 VDK74553.1 - 2.6e-15 55.9 0.0 5.1e-15 54.9 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 VDK74553.1 - 9e-14 51.3 0.0 2.9e-13 49.7 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 VDK74553.1 - 0.00073 19.4 1.0 0.00073 19.4 1.0 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase BRCT_3 PF18428.1 VDK74554.1 - 1.6e-16 60.2 0.0 5.4e-14 52.1 0.1 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 VDK74554.1 - 2.8e-13 50.0 0.0 8.4e-12 45.3 0.0 2.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 VDK74554.1 - 1e-12 48.3 0.1 1.5e-09 38.2 0.0 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 VDK74554.1 - 8.7e-08 32.0 0.0 3.5e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain Tudor_3 PF18115.1 VDK74554.1 - 0.0019 18.0 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain SRP54 PF00448.22 VDK74555.1 - 5e-52 176.4 1.5 1.2e-51 175.2 1.5 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 VDK74555.1 - 1.8e-41 143.0 24.6 2.6e-41 142.5 24.6 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 VDK74555.1 - 1.5e-10 41.2 0.1 5.9e-10 39.2 0.1 2.1 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 VDK74555.1 - 1.7e-06 27.3 0.0 5.4e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 VDK74555.1 - 5.8e-05 22.9 0.1 0.00013 21.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 VDK74555.1 - 0.0025 17.9 5.2 0.14 12.2 0.1 3.1 4 0 0 4 4 4 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 VDK74555.1 - 0.0028 17.9 0.1 0.013 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 VDK74555.1 - 0.0051 17.0 0.1 0.022 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 VDK74555.1 - 0.0057 17.0 0.0 0.019 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 VDK74555.1 - 0.0063 15.8 0.0 0.022 14.1 0.0 1.9 1 1 0 1 1 1 1 Zeta toxin ArsA_ATPase PF02374.15 VDK74555.1 - 0.0082 15.4 0.0 0.0082 15.4 0.0 2.5 3 0 0 3 3 3 1 Anion-transporting ATPase MMR_HSR1 PF01926.23 VDK74555.1 - 0.012 15.7 3.2 0.017 15.2 0.0 2.8 3 1 0 3 3 3 0 50S ribosome-binding GTPase AAA_31 PF13614.6 VDK74555.1 - 0.014 15.4 0.2 0.062 13.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 VDK74555.1 - 0.025 14.5 0.1 1.1 9.2 0.0 3.1 3 0 0 3 3 3 0 RsgA GTPase Fer4_NifH PF00142.18 VDK74555.1 - 0.025 14.0 0.1 0.081 12.4 0.0 1.9 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 VDK74555.1 - 0.026 14.0 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase ABC_tran PF00005.27 VDK74555.1 - 0.31 11.6 5.2 0.7 10.4 0.0 3.2 2 1 0 2 2 2 0 ABC transporter DUF3452 PF11934.8 VDK74555.1 - 0.7 9.4 4.5 1.9 8.1 1.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3452) RAB3GAP2_N PF14655.6 VDK74556.1 - 3.4e-111 372.5 0.0 4.6e-111 372.0 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus RAB3GAP2_C PF14656.6 VDK74556.1 - 1.6e-42 145.6 9.9 7.3e-40 136.8 9.9 3.2 1 1 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus TB2_DP1_HVA22 PF03134.19 VDK74557.1 - 8e-23 80.2 8.0 1.4e-22 79.4 8.0 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family HpcH_HpaI PF03328.14 VDK74557.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family BCNT PF07572.12 VDK74558.1 - 4.5e-25 87.5 0.2 1.1e-24 86.3 0.2 1.6 1 0 0 1 1 1 1 Bucentaur or craniofacial development CDC45 PF02724.14 VDK74558.1 - 0.5 8.6 5.1 0.47 8.7 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SPC12 PF06645.13 VDK74561.1 - 1.6e-27 95.3 1.2 1.9e-27 95.1 1.2 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) Lon_C PF05362.13 VDK74564.1 - 1.2e-69 234.0 0.0 3.2e-58 196.7 0.0 2.6 2 0 0 2 2 2 2 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 VDK74564.1 - 2.3e-29 102.8 2.1 5.3e-29 101.6 2.1 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 VDK74564.1 - 1e-23 84.2 0.1 7.4e-23 81.4 0.0 2.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 VDK74564.1 - 7.4e-09 35.7 0.0 1.5e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 VDK74564.1 - 1.8e-08 34.2 0.0 5.4e-08 32.7 0.0 1.9 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_PrkA PF08298.11 VDK74564.1 - 1.9e-06 27.0 0.1 3.1e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 PrkA AAA domain AAA_2 PF07724.14 VDK74564.1 - 2e-06 28.1 0.1 7.8e-06 26.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 VDK74564.1 - 2.3e-06 28.1 0.3 1.1e-05 25.9 0.0 2.2 2 1 1 3 3 1 1 AAA ATPase domain AAA_22 PF13401.6 VDK74564.1 - 1.5e-05 25.3 0.6 0.00063 20.0 0.0 3.2 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 VDK74564.1 - 7e-05 22.2 1.3 9.9e-05 21.7 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain RuvB_N PF05496.12 VDK74564.1 - 0.00052 19.8 0.0 0.0027 17.5 0.0 2.1 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 VDK74564.1 - 0.0017 18.4 0.0 0.016 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK74564.1 - 0.0025 17.5 0.1 0.0081 15.9 0.0 1.9 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 VDK74564.1 - 0.0026 18.1 0.0 0.013 15.9 0.0 2.2 2 0 0 2 2 1 1 RNA helicase AAA_11 PF13086.6 VDK74564.1 - 0.0034 17.2 3.4 0.014 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain Torsin PF06309.11 VDK74564.1 - 0.0045 17.1 0.2 0.048 13.8 0.0 2.4 2 0 0 2 2 2 1 Torsin IstB_IS21 PF01695.17 VDK74564.1 - 0.0091 15.7 0.0 0.023 14.4 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 VDK74564.1 - 0.0093 16.5 1.5 0.029 14.9 0.0 2.6 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 VDK74564.1 - 0.01 15.8 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 VDK74564.1 - 0.011 15.6 0.0 0.043 13.7 0.0 2.0 1 0 0 1 1 1 0 NACHT domain AAA_33 PF13671.6 VDK74564.1 - 0.02 15.0 0.0 0.061 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 VDK74564.1 - 0.021 14.6 0.0 0.06 13.1 0.0 1.8 1 0 0 1 1 1 0 Cytidylate kinase AAA_3 PF07726.11 VDK74564.1 - 0.026 14.4 0.0 0.07 13.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 VDK74564.1 - 0.031 13.5 0.6 0.072 12.3 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain Cellulase PF00150.18 VDK74564.1 - 0.033 13.6 0.0 0.068 12.6 0.0 1.5 1 1 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) AAA_7 PF12775.7 VDK74564.1 - 0.036 13.6 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 VDK74564.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.7 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CPT PF07931.12 VDK74564.1 - 0.056 13.3 0.0 0.16 11.8 0.0 1.8 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein NTPase_1 PF03266.15 VDK74564.1 - 0.057 13.3 0.2 0.53 10.2 0.0 2.7 2 1 1 3 3 3 0 NTPase AAA_19 PF13245.6 VDK74564.1 - 0.071 13.5 0.0 0.071 13.5 0.0 2.8 2 2 0 3 3 3 0 AAA domain Baculo_LEF5_C PF11792.8 VDK74564.1 - 0.086 12.5 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain ABC_tran PF00005.27 VDK74564.1 - 0.11 13.0 1.6 0.56 10.7 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_28 PF13521.6 VDK74564.1 - 0.12 12.6 0.0 0.77 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 VDK74564.1 - 0.13 11.6 0.0 0.44 9.9 0.0 1.8 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 VDK74564.1 - 0.15 11.2 0.0 0.32 10.1 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_23 PF13476.6 VDK74564.1 - 0.24 11.9 0.0 0.24 11.9 0.0 3.1 3 1 0 3 3 1 0 AAA domain DUF968 PF06147.11 VDK74564.1 - 0.29 11.4 3.1 2.9 8.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF968) DNTTIP1_dimer PF18192.1 VDK74564.1 - 1.3 9.4 4.6 11 6.5 0.2 3.3 3 1 1 4 4 2 0 DNTTIP1 dimerisation domain Phage_sheath_1C PF17482.2 VDK74566.1 - 0.0033 17.4 0.0 0.0045 16.9 0.0 1.1 1 0 0 1 1 1 1 Phage tail sheath C-terminal domain RF-1 PF00472.20 VDK74566.1 - 0.019 14.9 0.3 0.02 14.8 0.3 1.1 1 0 0 1 1 1 0 RF-1 domain TPR_2 PF07719.17 VDK74567.1 - 6.7e-09 35.2 2.0 0.00041 20.3 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK74567.1 - 9.1e-08 31.6 3.8 6.9e-05 22.5 0.4 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK74567.1 - 3.8e-06 27.1 5.7 0.00064 20.0 0.1 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK74567.1 - 0.00026 20.8 1.1 0.08 13.0 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK74567.1 - 0.0016 19.0 0.1 0.23 12.2 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat ZapB PF06005.12 VDK74567.1 - 0.0027 18.1 1.4 0.0027 18.1 1.4 2.4 2 0 0 2 2 2 1 Cell division protein ZapB TPR_11 PF13414.6 VDK74567.1 - 0.035 13.8 2.4 10 5.9 0.0 3.5 2 1 1 3 3 3 0 TPR repeat TPR_6 PF13174.6 VDK74567.1 - 0.036 14.7 0.8 8 7.3 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK74567.1 - 0.037 14.2 2.9 1.9 8.9 0.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat UPF0242 PF06785.11 VDK74567.1 - 0.046 13.8 7.9 0.37 10.9 0.4 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus MRPL52 PF18699.1 VDK74567.1 - 0.053 13.7 0.7 0.053 13.7 0.7 2.4 2 0 0 2 2 2 0 Mitoribosomal protein mL52 SHNi-TPR PF10516.9 VDK74567.1 - 0.061 12.8 0.4 0.31 10.5 0.2 2.3 3 0 0 3 3 3 0 SHNi-TPR YcbB PF08664.10 VDK74567.1 - 0.069 13.2 1.7 0.27 11.3 0.1 2.1 2 0 0 2 2 2 0 YcbB domain DUF4407 PF14362.6 VDK74567.1 - 0.1 11.9 0.7 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TPR_10 PF13374.6 VDK74567.1 - 0.19 11.7 0.6 0.99 9.4 0.2 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4574 PF15141.6 VDK74567.1 - 2.6 8.0 7.1 0.26 11.2 1.8 1.9 2 1 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 GRIM-19 PF06212.12 VDK74568.1 - 7.7e-47 158.6 0.2 9.2e-47 158.3 0.2 1.1 1 0 0 1 1 1 1 GRIM-19 protein Ribosomal_S19e PF01090.19 VDK74569.1 - 1.2e-56 190.3 0.2 1.3e-56 190.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e IF3_C PF00707.22 VDK74569.1 - 0.089 12.8 0.1 20 5.2 0.0 2.7 2 1 1 3 3 3 0 Translation initiation factor IF-3, C-terminal domain ANAPC4_WD40 PF12894.7 VDK74570.1 - 0.00034 20.9 6.7 0.47 10.8 0.0 5.6 5 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 VDK74570.1 - 0.21 11.5 1.3 2 8.3 0.3 2.6 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Thioredoxin_6 PF13848.6 VDK74571.1 - 5.3e-08 33.0 0.0 1.8e-06 28.0 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like domain HyaE PF07449.11 VDK74571.1 - 1.9e-05 24.6 0.1 8.1e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 VDK74571.1 - 0.0025 17.7 0.0 0.015 15.1 0.0 2.2 2 1 0 2 2 2 1 F plasmid transfer operon protein HAD_SAK_2 PF18143.1 VDK74571.1 - 0.015 15.6 0.1 0.052 13.9 0.1 1.9 1 0 0 1 1 1 0 HAD domain in Swiss Army Knife RNA repair proteins ERp29_N PF07912.13 VDK74571.1 - 0.081 13.1 0.0 0.42 10.8 0.0 2.0 2 0 0 2 2 2 0 ERp29, N-terminal domain PUA PF01472.20 VDK74571.1 - 0.12 12.4 0.1 0.3 11.1 0.1 1.7 1 0 0 1 1 1 0 PUA domain DUF4820 PF16091.5 VDK74571.1 - 0.45 9.9 3.3 0.68 9.3 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) BAR PF03114.18 VDK74594.1 - 4e-67 226.3 10.7 4.6e-67 226.1 10.7 1.0 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 VDK74594.1 - 0.00049 19.3 4.9 0.00049 19.3 4.9 1.7 1 1 1 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking ERM PF00769.19 VDK74594.1 - 0.0054 16.6 0.8 0.0054 16.6 0.8 2.2 2 0 0 2 2 2 1 Ezrin/radixin/moesin family YdfA_immunity PF12127.8 VDK74594.1 - 0.08 12.0 0.2 0.12 11.5 0.2 1.2 1 0 0 1 1 1 0 SigmaW regulon antibacterial Dsl1_N PF11988.8 VDK74596.1 - 0.01 14.8 0.5 0.022 13.8 0.5 1.5 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal DUF4525 PF15027.6 VDK74596.1 - 0.024 14.4 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) AMMECR1 PF01871.17 VDK74597.1 - 2.4e-48 163.9 0.0 2.9e-48 163.6 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 DUF2194 PF09960.9 VDK74598.1 - 0.011 14.1 0.4 0.02 13.3 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2194) MCLC PF05934.11 VDK74599.1 - 0.02 13.6 0.4 0.038 12.7 0.1 1.5 1 1 1 2 2 2 0 Mid-1-related chloride channel (MCLC) EH_Signature PF15611.6 VDK74599.1 - 0.081 12.3 0.1 6.3 6.1 0.1 2.0 2 0 0 2 2 2 0 EH_Signature domain Cadherin_C_2 PF16492.5 VDK74601.1 - 8.3 7.2 6.7 2.5 8.9 2.5 1.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Pkinase PF00069.25 VDK74602.1 - 3.2e-60 203.7 0.0 4.3e-60 203.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74602.1 - 1.8e-31 109.4 0.0 2.7e-31 108.8 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK74602.1 - 0.00037 20.5 0.1 0.0034 17.4 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 VDK74602.1 - 0.00056 19.0 0.2 0.0009 18.3 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 VDK74602.1 - 0.0044 16.4 1.0 0.0082 15.5 0.9 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK74602.1 - 0.049 12.9 0.0 0.076 12.3 0.0 1.4 1 1 0 1 1 1 0 Kinase-like RIO1 PF01163.22 VDK74602.1 - 0.08 12.5 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 VDK74602.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL WD40 PF00400.32 VDK74604.1 - 5.2e-30 103.1 11.6 1.8e-06 28.5 0.2 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat ATG16 PF08614.11 VDK74604.1 - 1.3e-15 58.2 23.4 1.4e-14 54.8 23.4 2.1 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) ANAPC4_WD40 PF12894.7 VDK74604.1 - 3.9e-13 49.5 0.3 0.0028 17.9 0.0 4.5 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Occludin_ELL PF07303.13 VDK74604.1 - 0.0013 19.4 12.0 0.0047 17.6 0.0 2.5 2 0 0 2 2 2 1 Occludin homology domain Nup160 PF11715.8 VDK74604.1 - 0.0087 14.8 2.2 0.41 9.2 0.2 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 VDK74604.1 - 0.023 14.6 0.1 7.5 6.4 0.0 3.1 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 VDK74604.1 - 0.051 12.9 0.3 11 5.3 0.0 3.0 1 1 2 3 3 3 0 WD40-like domain KELK PF15796.5 VDK74604.1 - 0.46 11.0 24.1 0.041 14.3 9.9 3.0 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase LAM_C PF12544.8 VDK74604.1 - 0.92 9.7 3.0 2.4 8.3 1.8 2.2 1 1 1 2 2 2 0 Lysine-2,3-aminomutase Laminin_II PF06009.12 VDK74604.1 - 4.1 7.4 12.3 1.7 8.6 9.3 1.9 1 1 1 2 2 2 0 Laminin Domain II Exonuc_VII_L PF02601.15 VDK74604.1 - 5.3 6.5 8.6 8.4 5.9 8.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit p450 PF00067.22 VDK74607.1 - 1.1e-60 205.7 2.9 5.9e-59 200.0 2.9 2.6 1 1 0 1 1 1 1 Cytochrome P450 zf-C3HC4 PF00097.25 VDK74608.1 - 6.8e-09 35.5 9.8 1.2e-08 34.7 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK74608.1 - 2e-08 34.0 10.9 3.8e-08 33.1 10.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 VDK74608.1 - 3.4e-08 33.4 5.3 3.4e-08 33.4 5.3 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 VDK74608.1 - 3.6e-07 30.2 12.1 6.8e-07 29.3 12.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 VDK74608.1 - 6e-07 29.7 10.8 9.9e-07 29.0 10.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 VDK74608.1 - 8.9e-06 25.5 8.7 1.6e-05 24.6 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK74608.1 - 1.4e-05 24.9 12.2 5.8e-05 22.9 12.2 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK74608.1 - 0.00067 19.7 3.2 0.0013 18.7 3.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 VDK74608.1 - 0.0029 17.4 2.6 0.0029 17.4 2.6 2.0 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 VDK74608.1 - 0.035 14.0 12.7 0.73 9.7 12.9 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF2525 PF10733.9 VDK74608.1 - 0.083 13.2 0.1 1.1 9.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2525) zf-rbx1 PF12678.7 VDK74608.1 - 0.12 12.7 7.5 0.57 10.5 7.6 2.0 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-4CXXC_R1 PF10497.9 VDK74608.1 - 0.7 10.1 6.7 3.8 7.8 6.9 1.8 1 1 1 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DUF1272 PF06906.11 VDK74608.1 - 1.5 9.0 9.2 0.2 11.8 4.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-Nse PF11789.8 VDK74608.1 - 2.3 8.1 8.4 5.7 6.8 7.4 2.1 2 1 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DZR PF12773.7 VDK74608.1 - 6.4 6.9 9.9 58 3.8 10.6 2.0 1 1 1 2 2 2 0 Double zinc ribbon FYVE PF01363.21 VDK74608.1 - 9.1 6.5 11.2 30 4.8 11.2 2.0 1 1 0 1 1 1 0 FYVE zinc finger Med27 PF11571.8 VDK74610.1 - 1.3e-13 51.1 0.9 5e-13 49.2 0.9 2.1 1 0 0 1 1 1 1 Mediator complex subunit 27 Herpes_UL6 PF01763.16 VDK74610.1 - 0.0027 16.3 0.8 0.0056 15.3 0.3 1.8 2 0 0 2 2 2 1 Herpesvirus UL6 like MutS_III PF05192.18 VDK74610.1 - 0.019 15.2 5.6 3.3 7.9 5.7 2.7 1 1 0 1 1 1 0 MutS domain III Barttin PF15462.6 VDK74610.1 - 0.046 13.5 1.9 0.076 12.8 1.5 1.5 1 1 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) K-box PF01486.17 VDK74610.1 - 0.4 10.9 4.6 2.8 8.2 0.2 3.1 3 0 0 3 3 3 0 K-box region ZapB PF06005.12 VDK74610.1 - 2.4 8.7 8.1 0.58 10.6 1.0 3.0 3 0 0 3 3 3 0 Cell division protein ZapB MAGE PF01454.19 VDK74611.1 - 2.1e-08 34.1 0.0 2.9e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 MAGE family TSP_1 PF00090.19 VDK74613.1 - 2.3e-44 149.4 122.5 4.7e-10 39.5 9.7 8.3 7 1 0 7 7 7 6 Thrombospondin type 1 domain ADAM_CR_2 PF17771.1 VDK74613.1 - 6.6e-17 61.8 3.5 6.6e-17 61.8 3.5 6.8 5 2 0 5 5 5 2 ADAM cysteine-rich domain Reprolysin PF01421.19 VDK74613.1 - 9.9e-14 51.7 0.0 2.3e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 VDK74613.1 - 1.3e-10 41.6 0.1 2.6e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_5 PF13688.6 VDK74613.1 - 2.7e-09 37.5 0.1 2.7e-09 37.5 0.1 2.5 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 VDK74613.1 - 2.6e-05 24.7 0.2 5.7e-05 23.6 0.2 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 VDK74613.1 - 0.0059 16.2 0.1 0.014 15.0 0.1 1.6 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Ion_trans_2 PF07885.16 VDK74618.1 - 5.8e-32 109.5 18.3 1.4e-15 57.0 7.4 3.2 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK74618.1 - 1.7e-09 37.2 13.3 1.5e-07 30.9 0.7 2.2 2 0 0 2 2 2 2 Ion transport protein Sugar_tr PF00083.24 VDK74620.1 - 2.4e-72 244.2 30.8 2.7e-72 244.1 30.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK74620.1 - 1.8e-25 89.6 30.5 1.8e-25 89.6 30.5 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily AAA PF00004.29 VDK74621.1 - 1e-50 171.6 0.0 5.7e-43 146.5 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK74621.1 - 1.1e-16 60.3 0.3 2.1e-10 40.2 0.1 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 VDK74621.1 - 7.2e-10 39.5 1.0 0.0022 18.4 0.0 3.6 2 2 1 3 3 3 2 AAA ATPase domain RuvB_N PF05496.12 VDK74621.1 - 8.1e-08 32.2 0.0 0.017 14.8 0.0 3.0 3 1 1 4 4 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 VDK74621.1 - 2e-07 31.1 0.0 0.00076 19.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 VDK74621.1 - 1.3e-05 25.5 0.0 0.045 14.1 0.0 3.0 3 0 0 3 3 2 2 RNA helicase Zeta_toxin PF06414.12 VDK74621.1 - 0.00016 21.0 0.0 0.013 14.8 0.0 2.7 3 0 0 3 3 3 1 Zeta toxin AAA_2 PF07724.14 VDK74621.1 - 0.00019 21.6 0.0 0.0064 16.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 VDK74621.1 - 0.00027 21.0 0.0 0.19 11.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 VDK74621.1 - 0.00055 19.9 0.0 0.077 12.8 0.0 3.3 2 2 0 2 2 2 1 Bacterial dnaA protein AAA_22 PF13401.6 VDK74621.1 - 0.00066 20.0 2.8 5.2 7.3 0.0 4.5 3 2 2 5 5 4 1 AAA domain T2SSE PF00437.20 VDK74621.1 - 0.001 18.2 0.0 0.0022 17.1 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.12 VDK74621.1 - 0.0014 18.6 0.5 0.26 11.2 0.1 3.5 3 1 0 4 4 4 1 NACHT domain TIP49 PF06068.13 VDK74621.1 - 0.0025 17.1 0.0 0.0085 15.3 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 VDK74621.1 - 0.0025 17.2 0.0 0.75 9.1 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 VDK74621.1 - 0.0034 16.6 0.0 0.17 11.0 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 VDK74621.1 - 0.0037 17.4 0.0 0.15 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 VDK74621.1 - 0.0055 16.7 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 VDK74621.1 - 0.0063 17.0 0.0 0.31 11.6 0.0 2.4 2 0 0 2 2 2 1 ABC transporter Rad17 PF03215.15 VDK74621.1 - 0.007 16.3 0.0 2.4 8.0 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_25 PF13481.6 VDK74621.1 - 0.0082 15.7 0.2 20 4.7 0.0 3.4 2 1 1 3 3 3 0 AAA domain Sigma54_activat PF00158.26 VDK74621.1 - 0.011 15.5 0.0 3.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 VDK74621.1 - 0.015 15.8 0.0 6.9 7.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 VDK74621.1 - 0.02 14.1 0.0 2.5 7.2 0.1 2.7 2 1 1 3 3 3 0 NB-ARC domain AAA_23 PF13476.6 VDK74621.1 - 0.06 13.8 0.1 0.24 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 VDK74621.1 - 0.1 12.1 0.5 18 4.8 0.0 2.6 3 0 0 3 3 2 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 VDK74621.1 - 0.14 12.2 0.0 2.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF4381 PF14316.6 VDK74622.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) TRM PF02005.16 VDK74624.1 - 8.8e-134 446.4 0.4 1.1e-133 446.0 0.4 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_15 PF09445.10 VDK74624.1 - 3.6e-05 23.4 0.0 7.7e-05 22.3 0.0 1.6 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 VDK74624.1 - 5.3e-05 23.1 0.1 0.0001 22.1 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein tRNA_U5-meth_tr PF05958.11 VDK74624.1 - 9.1e-05 21.6 0.1 0.00014 21.0 0.1 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 VDK74624.1 - 0.00014 21.7 0.1 0.0003 20.6 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK74624.1 - 0.0035 18.0 0.1 0.012 16.4 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 VDK74624.1 - 0.051 12.9 1.1 0.13 11.6 0.7 1.8 1 1 1 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 VDK74624.1 - 0.097 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Swi3 PF07962.12 VDK74624.1 - 0.14 12.1 0.0 0.71 9.9 0.0 2.1 2 0 0 2 2 2 0 Replication Fork Protection Component Swi3 Integrase_H2C2 PF17921.1 VDK74625.1 - 1.9e-14 53.5 0.2 7.8e-14 51.5 0.2 2.2 1 0 0 1 1 1 1 Integrase zinc binding domain zf-H2C2 PF09337.10 VDK74625.1 - 7.4e-05 22.9 0.0 0.00051 20.2 0.0 2.6 2 0 0 2 2 2 1 H2C2 zinc finger Myb_DNA-bind_3 PF12776.7 VDK74625.1 - 0.15 13.1 2.0 6.5 7.8 0.0 3.5 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain Motile_Sperm PF00635.26 VDK74627.1 - 8.1e-17 61.1 0.0 9.5e-17 60.8 0.0 1.0 1 0 0 1 1 1 1 MSP (Major sperm protein) domain G-patch PF01585.23 VDK74629.1 - 8.8e-16 57.5 0.5 1.7e-15 56.6 0.5 1.5 1 0 0 1 1 1 1 G-patch domain OCRE PF17780.1 VDK74629.1 - 1.3e-10 41.1 24.6 3.3e-10 39.8 23.1 2.2 2 0 0 2 2 2 1 OCRE domain G-patch_2 PF12656.7 VDK74629.1 - 6e-07 29.4 0.2 1.4e-06 28.3 0.2 1.6 1 0 0 1 1 1 1 G-patch domain UPF0058 PF01893.16 VDK74629.1 - 0.14 12.5 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0058 HSP20 PF00011.21 VDK74632.1 - 3.4e-13 49.6 0.0 6.1e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Sugar_tr PF00083.24 VDK74634.1 - 7.8e-28 97.5 19.2 1e-24 87.2 3.8 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 VDK74634.1 - 7.3e-10 38.3 25.8 9.7e-09 34.6 5.9 2.3 1 1 0 2 2 2 2 Major Facilitator Superfamily DUF4807 PF16065.5 VDK74634.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4807) Baculo_E25 PF05274.11 VDK74634.1 - 0.14 12.0 0.2 0.25 11.1 0.2 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein E25 L51_S25_CI-B8 PF05047.16 VDK74650.1 - 5.9e-09 35.7 0.0 3.6e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Rtf2 PF04641.12 VDK74651.1 - 4.1e-78 262.4 10.4 4.9e-78 262.1 10.4 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 VDK74651.1 - 0.04 13.7 0.9 0.56 10.1 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit BNIP2 PF12496.8 VDK74652.1 - 6.7 7.2 9.4 16 6.0 9.4 1.6 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 IF-2B PF01008.17 VDK74653.1 - 2.1e-33 115.7 3.6 5e-30 104.7 3.6 2.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Adap_comp_sub PF00928.21 VDK74654.1 - 1.7e-89 299.7 0.1 3.5e-89 298.7 0.0 1.5 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 VDK74654.1 - 0.0011 18.9 4.5 0.0021 18.0 4.5 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4079 PF13301.6 VDK74655.1 - 0.038 14.1 0.1 0.31 11.2 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) Phosphoesterase PF04185.14 VDK74655.1 - 0.13 11.5 0.0 0.16 11.2 0.0 1.0 1 0 0 1 1 1 0 Phosphoesterase family Filament PF00038.21 VDK74656.1 - 1.8e-48 165.7 64.3 5.5e-48 164.1 64.3 1.7 1 1 0 1 1 1 1 Intermediate filament protein LTD PF00932.19 VDK74656.1 - 6.1e-17 62.0 0.1 1.8e-16 60.5 0.1 1.7 1 0 0 1 1 1 1 Lamin Tail Domain FlxA PF14282.6 VDK74656.1 - 0.013 15.5 0.4 0.013 15.5 0.4 4.6 2 1 2 4 4 4 0 FlxA-like protein GbpA_2 PF18416.1 VDK74656.1 - 0.027 14.8 0.1 0.76 10.1 0.0 3.0 2 1 1 3 3 3 0 N-acetylglucosamine binding protein domain 2 DUF4407 PF14362.6 VDK74656.1 - 0.26 10.6 34.8 0.11 11.8 12.5 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 VDK74656.1 - 0.53 10.4 55.8 0.44 10.6 22.7 5.3 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein Speriolin_N PF15058.6 VDK74656.1 - 0.69 10.0 4.5 0.33 11.0 1.2 2.2 2 0 0 2 2 2 0 Speriolin N terminus 5_3_exonuc_N PF02739.16 VDK74656.1 - 5.2 7.0 7.7 0.66 9.9 1.5 2.4 3 0 0 3 3 3 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF3584 PF12128.8 VDK74656.1 - 6.1 4.2 46.2 15 2.9 45.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Na_H_Exchanger PF00999.21 VDK74657.1 - 8.8e-60 202.5 35.7 1.1e-59 202.2 35.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PAW PF04721.17 VDK74658.1 - 1.8e-25 89.9 0.0 3.1e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 PNGase C-terminal domain, mannose-binding module PAW Thioredoxin PF00085.20 VDK74658.1 - 6.3e-25 87.2 0.0 1.8e-24 85.7 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin Transglut_core PF01841.19 VDK74658.1 - 5.5e-13 49.4 0.5 1.2e-12 48.2 0.5 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.15 VDK74658.1 - 1.4e-08 34.6 0.6 3e-08 33.5 0.6 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Thioredoxin_2 PF13098.6 VDK74658.1 - 1.1e-05 25.9 0.1 0.00015 22.2 0.1 2.7 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK74658.1 - 9.4e-05 22.7 0.4 0.0013 19.0 0.0 2.6 2 1 1 3 3 3 1 Thioredoxin-like Thioredoxin_9 PF14595.6 VDK74658.1 - 0.00015 21.6 0.3 0.008 16.0 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin TraF PF13728.6 VDK74658.1 - 0.004 17.0 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 VDK74658.1 - 0.004 17.3 0.0 0.0099 16.0 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 VDK74658.1 - 0.0047 16.8 0.0 0.0099 15.8 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK74658.1 - 0.032 13.9 0.0 0.065 12.9 0.0 1.5 1 0 0 1 1 1 0 Redoxin NuA4 PF09340.10 VDK74658.1 - 0.036 14.0 0.0 0.094 12.6 0.0 1.7 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 Pro_isomerase PF00160.21 VDK74660.1 - 7e-35 120.6 0.1 1.2e-31 110.2 0.1 2.1 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase PF00069.25 VDK74662.1 - 4.7e-31 108.1 0.0 5.8e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74662.1 - 9.1e-17 61.2 0.0 1.1e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PB1 PF00564.24 VDK74662.1 - 0.0089 15.9 0.0 0.018 14.9 0.0 1.6 1 0 0 1 1 1 1 PB1 domain Pkinase_fungal PF17667.1 VDK74662.1 - 0.052 12.3 0.0 0.073 11.8 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 VDK74662.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 VDK74664.1 - 2.3e-06 27.2 0.0 2.3e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74664.1 - 1.6e-05 24.3 0.0 1.6e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase TM2 PF05154.16 VDK74666.1 - 1.1e-13 51.3 9.2 1.7e-13 50.6 9.2 1.3 1 0 0 1 1 1 1 TM2 domain MRP-S27 PF10037.9 VDK74667.1 - 3.6e-67 226.9 3.4 3.6e-67 226.9 3.4 1.4 2 0 0 2 2 2 1 Mitochondrial 28S ribosomal protein S27 PDE4_UCR PF18100.1 VDK74667.1 - 0.12 13.0 1.1 0.59 10.8 0.8 2.1 2 0 0 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) Reprolysin_2 PF13574.6 VDK74668.1 - 9.5e-30 103.9 0.5 1.9e-29 103.0 0.5 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 VDK74668.1 - 9.5e-28 97.7 0.3 9.5e-28 97.7 0.3 2.2 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 VDK74668.1 - 5.1e-20 72.2 0.1 9.8e-20 71.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 VDK74668.1 - 1.6e-07 31.2 0.4 4.3e-07 29.8 0.4 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 VDK74668.1 - 7.7e-05 22.7 0.0 7.7e-05 22.7 0.0 2.0 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease NDUF_B7 PF05676.13 VDK74670.1 - 2.9e-24 84.5 6.2 3.8e-24 84.2 6.2 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) AAA_18 PF13238.6 VDK74670.1 - 0.073 13.6 0.6 0.086 13.4 0.6 1.2 1 0 0 1 1 1 0 AAA domain Epimerase PF01370.21 VDK74672.1 - 1.1e-50 172.3 0.0 1.4e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 VDK74672.1 - 3.2e-49 168.1 0.0 6.6e-49 167.1 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 VDK74672.1 - 1.5e-17 63.6 0.0 3e-16 59.4 0.0 2.3 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 VDK74672.1 - 1.9e-13 50.1 0.1 3.6e-13 49.1 0.1 1.4 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 VDK74672.1 - 7.8e-11 41.6 0.0 1.4e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 VDK74672.1 - 1.5e-07 30.9 0.0 6.8e-07 28.7 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 VDK74672.1 - 2.5e-07 30.8 0.0 5.3e-07 29.7 0.0 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 VDK74672.1 - 0.00014 21.9 0.0 0.00067 19.6 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 VDK74672.1 - 0.00082 18.9 0.0 0.0012 18.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 VDK74672.1 - 0.016 14.8 0.1 0.14 11.7 0.1 2.1 2 0 0 2 2 2 0 NmrA-like family Methyltransf_31 PF13847.6 VDK74672.1 - 0.049 13.4 0.1 12 5.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Ldh_1_N PF00056.23 VDK74672.1 - 0.091 12.8 0.1 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 VDK74672.1 - 0.15 11.6 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GTP_EFTU PF00009.27 VDK74673.1 - 5.9e-28 97.7 0.6 9.5e-28 97.1 0.6 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDK74673.1 - 1.4e-10 41.2 0.1 2.9e-10 40.2 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 VDK74673.1 - 9.1e-07 29.2 0.2 6.1e-05 23.3 0.1 2.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 SRPRB PF09439.10 VDK74673.1 - 7.1e-06 25.6 0.3 1.3e-05 24.7 0.3 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RIBIOP_C PF04950.12 VDK74673.1 - 1.6e-05 24.5 0.8 2.6e-05 23.8 0.8 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal FeoB_N PF02421.18 VDK74673.1 - 0.00018 21.1 1.3 0.0009 18.8 1.4 2.2 1 1 1 2 2 2 1 Ferrous iron transport protein B PduV-EutP PF10662.9 VDK74673.1 - 0.00037 20.3 0.6 0.0042 16.8 0.6 2.2 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 VDK74673.1 - 0.001 18.6 0.6 0.0027 17.2 0.2 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family cobW PF02492.19 VDK74673.1 - 0.0037 16.9 2.3 0.0049 16.5 0.3 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 VDK74673.1 - 0.0045 16.2 0.3 1.6 7.8 0.1 2.2 2 0 0 2 2 2 2 G-protein alpha subunit RsgA_GTPase PF03193.16 VDK74673.1 - 0.067 13.1 3.4 0.098 12.5 0.6 2.3 1 1 1 2 2 2 0 RsgA GTPase TbpB_C PF17483.2 VDK74673.1 - 0.14 12.6 0.1 0.33 11.3 0.1 1.6 1 0 0 1 1 1 0 C-lobe handle domain of Tf-binding protein B ABC_tran PF00005.27 VDK74673.1 - 0.16 12.5 0.3 0.49 10.9 0.1 1.9 2 0 0 2 2 2 0 ABC transporter GTP_EFTU_D4 PF14578.6 VDK74673.1 - 0.21 11.5 0.9 1.6 8.7 0.0 2.6 3 1 0 3 3 3 0 Elongation factor Tu domain 4 PWI PF01480.17 VDK74677.1 - 3.9e-29 100.8 0.1 6.7e-29 100.0 0.1 1.4 1 0 0 1 1 1 1 PWI domain Fer2 PF00111.27 VDK74679.1 - 8.4e-06 25.6 0.2 1.2e-05 25.2 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Glycos_transf_2 PF00535.26 VDK74680.1 - 5e-13 49.2 0.0 6.8e-13 48.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 VDK74680.1 - 0.00051 19.6 0.0 0.0007 19.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 VDK74680.1 - 0.014 15.3 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Motile_Sperm PF00635.26 VDK74683.1 - 1.3e-17 63.7 0.0 1.5e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 MSP (Major sperm protein) domain P19Arf_N PF07392.12 VDK74683.1 - 0.025 15.0 0.0 0.042 14.3 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus Pkinase PF00069.25 VDK74685.1 - 4.1e-62 209.9 0.3 4.8e-62 209.7 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74685.1 - 2.4e-47 161.4 0.1 3e-47 161.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK74685.1 - 3.3e-06 26.1 0.0 2.8e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 VDK74685.1 - 4.1e-05 23.1 0.0 5.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK74685.1 - 0.00065 19.1 0.3 0.002 17.5 0.3 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 VDK74685.1 - 0.044 12.7 0.8 0.094 11.6 0.8 1.6 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 VDK74685.1 - 0.26 11.2 0.0 0.44 10.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M13_N PF05649.13 VDK74695.1 - 1.2e-93 314.8 3.5 5.5e-93 312.7 3.5 1.9 1 1 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 VDK74695.1 - 2e-69 233.3 0.1 2e-69 233.3 0.1 1.9 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M4 PF01447.18 VDK74695.1 - 0.24 11.9 2.0 0.61 10.6 2.0 1.7 1 1 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain DUF1965 PF09248.10 VDK74695.1 - 0.29 10.9 1.8 0.41 10.5 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1965) Ion_trans_2 PF07885.16 VDK74697.1 - 4.7e-33 113.0 20.0 4.8e-17 61.7 1.4 2.7 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK74697.1 - 4.4e-08 32.7 5.2 0.0012 18.1 0.0 2.2 1 1 0 2 2 2 2 Ion transport protein AA_permease PF00324.21 VDK74698.1 - 9e-34 116.9 38.7 9e-34 116.9 38.7 1.5 2 0 0 2 2 2 1 Amino acid permease BRX PF08381.11 VDK74698.1 - 0.25 10.8 0.2 0.7 9.3 0.2 1.7 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 Rootletin PF15035.6 VDK74699.1 - 3.9e-33 115.1 30.8 3.9e-33 115.1 30.8 15.2 3 2 12 15 15 15 2 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.11 VDK74699.1 - 4.5e-06 25.8 7.9 4.5e-06 25.8 7.9 15.9 2 2 10 15 15 15 9 Spc7 kinetochore protein Tropomyosin PF00261.20 VDK74699.1 - 7.3e-05 22.2 26.3 7.3e-05 22.2 26.3 13.6 4 3 6 13 13 13 4 Tropomyosin HALZ PF02183.18 VDK74699.1 - 0.0007 19.8 2.4 0.0007 19.8 2.4 17.4 19 0 0 19 19 19 1 Homeobox associated leucine zipper GAS PF13851.6 VDK74699.1 - 0.0015 17.9 12.1 0.0015 17.9 12.1 17.3 3 2 12 16 16 16 8 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 VDK74699.1 - 0.0029 17.9 12.2 0.0029 17.9 12.2 17.7 4 3 13 18 18 18 7 Autophagy protein 16 (ATG16) SlyX PF04102.12 VDK74699.1 - 0.028 15.0 0.1 0.028 15.0 0.1 25.9 16 8 12 29 29 29 0 SlyX CSN7a_helixI PF18392.1 VDK74699.1 - 0.54 10.2 8.1 3 7.8 0.3 4.7 3 0 0 3 3 3 0 COP9 signalosome complex subunit 7a helix I domain zf-C2H2 PF00096.26 VDK74703.1 - 4.7e-19 67.7 55.9 0.0042 17.5 2.1 8.0 8 0 0 8 8 8 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK74703.1 - 2.9e-17 61.9 46.2 0.0038 17.9 1.1 7.6 7 0 0 7 7 7 6 C2H2-type zinc finger zf-met PF12874.7 VDK74703.1 - 3.7e-06 27.1 12.8 0.013 15.8 0.1 5.1 5 0 0 5 5 4 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK74703.1 - 4.9e-06 26.7 22.5 0.022 15.0 0.0 6.2 6 0 0 6 6 6 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK74703.1 - 0.00051 20.0 40.9 0.14 12.2 0.3 7.4 7 0 0 7 7 7 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK74703.1 - 0.00094 19.5 43.8 0.045 14.2 0.0 8.7 8 1 0 8 8 8 2 Zinc-finger double domain zf-Di19 PF05605.12 VDK74703.1 - 0.00098 19.4 21.7 0.21 11.9 1.2 4.8 3 1 1 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 VDK74703.1 - 0.0013 19.4 22.8 0.057 14.1 0.9 5.2 1 1 4 5 5 5 2 Zinc finger C2H2-type, 3 repeats zf_C2H2_ZHX PF18387.1 VDK74703.1 - 0.0038 16.8 15.6 0.13 11.9 3.0 5.1 4 1 1 5 5 5 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_11 PF16622.5 VDK74703.1 - 0.0073 16.0 23.6 0.024 14.4 1.8 5.8 5 0 0 5 5 5 2 zinc-finger C2H2-type zf-CSL PF05207.13 VDK74703.1 - 0.37 10.6 4.2 0.8 9.5 0.3 3.1 3 0 0 3 3 2 0 CSL zinc finger HNH_5 PF14279.6 VDK74703.1 - 0.45 10.4 15.5 4.6 7.2 0.2 5.8 4 1 1 5 5 5 0 HNH endonuclease Ta0938 PF11494.8 VDK74703.1 - 1.2 9.4 7.8 4.3 7.7 0.0 3.8 2 2 3 5 5 5 0 Ta0938 FOXP-CC PF16159.5 VDK74703.1 - 4.7 7.9 12.1 17 6.1 0.4 4.8 5 0 0 5 5 5 0 FOXP coiled-coil domain Zn-ribbon_8 PF09723.10 VDK74703.1 - 5.3 7.3 27.3 1.5 9.0 1.3 6.6 6 0 0 6 6 6 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 VDK74703.1 - 5.5 7.4 31.1 21 5.5 0.3 6.1 1 1 5 6 6 6 0 C2H2 type zinc-finger (2 copies) ADK_lid PF05191.14 VDK74703.1 - 5.5 7.1 9.5 35 4.5 0.7 4.6 5 1 0 5 5 5 0 Adenylate kinase, active site lid Nipped-B_C PF12830.7 VDK74707.1 - 9.8e-40 136.5 0.2 9.8e-40 136.5 0.2 6.5 6 1 0 6 6 6 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 VDK74707.1 - 9.4e-09 35.4 1.0 7.4e-08 32.6 0.2 2.9 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT_2 PF13646.6 VDK74707.1 - 1.6e-07 31.6 0.8 0.015 15.7 0.2 5.3 5 1 1 6 6 6 3 HEAT repeats Cnd1 PF12717.7 VDK74707.1 - 2.1e-07 31.1 2.1 0.0033 17.5 0.1 4.4 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 TFIIA PF03153.13 VDK74707.1 - 0.00035 20.7 44.6 0.00035 20.7 44.6 3.2 3 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit HEAT PF02985.22 VDK74707.1 - 0.00099 19.2 1.7 4.4 7.8 0.0 6.1 5 1 1 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 VDK74707.1 - 0.0018 18.7 0.0 8.6 7.0 0.0 5.5 5 0 0 5 5 5 1 HEAT-like repeat Thiolase_C PF02803.18 VDK74707.1 - 0.041 13.5 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 Thiolase, C-terminal domain HDA2-3 PF11496.8 VDK74709.1 - 0.033 13.4 0.2 0.037 13.2 0.2 1.1 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 CppA_C PF14507.6 VDK74709.1 - 0.033 14.9 0.6 0.053 14.3 0.6 1.4 1 0 0 1 1 1 0 CppA C-terminal SMP_C2CD2L PF18696.1 VDK74709.1 - 0.035 13.9 0.4 0.048 13.5 0.4 1.3 1 0 0 1 1 1 0 Synaptotagmin-like, mitochondrial and lipid-binding domain CDC37_N PF03234.14 VDK74709.1 - 0.72 10.8 7.3 1.7 9.6 7.2 1.6 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding CheY-binding PF09078.11 VDK74710.1 - 0.57 10.4 2.0 0.53 10.5 0.2 1.9 2 0 0 2 2 2 0 CheY binding Spectrin PF00435.21 VDK74725.1 - 1.1e-262 851.8 168.8 1.6e-19 70.3 5.5 17.3 17 0 0 17 17 17 17 Spectrin repeat CH PF00307.31 VDK74725.1 - 4.7e-47 158.7 3.6 1.1e-24 86.7 0.0 4.9 5 0 0 5 5 5 2 Calponin homology (CH) domain PH_9 PF15410.6 VDK74725.1 - 1.1e-15 58.1 0.8 8.4e-15 55.2 0.1 2.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 VDK74725.1 - 2e-14 54.0 2.8 3.9e-13 49.8 0.0 3.1 3 0 0 3 3 3 1 PH domain CAMSAP_CH PF11971.8 VDK74725.1 - 1e-06 28.5 0.1 8.6e-05 22.3 0.0 2.9 2 0 0 2 2 2 1 CAMSAP CH domain DUF5616 PF18481.1 VDK74725.1 - 0.003 17.9 1.3 22 5.4 0.0 4.6 4 0 0 4 4 4 2 Domain of unknown function (DUF5616) PH_11 PF15413.6 VDK74725.1 - 0.021 15.2 3.7 1.7 9.1 0.3 3.6 2 1 0 2 2 2 0 Pleckstrin homology domain RhoGAP PF00620.27 VDK74727.1 - 7.9e-27 94.0 0.1 2.5e-26 92.3 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain DUF4598 PF15370.6 VDK74727.1 - 4 8.0 6.1 4.5 7.8 2.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) Ank_2 PF12796.7 VDK74731.1 - 1.2e-11 45.0 0.0 5e-11 43.0 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 VDK74731.1 - 4.1e-08 33.3 0.1 0.00019 21.7 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 VDK74731.1 - 1.7e-06 28.4 0.1 0.00012 22.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK74731.1 - 9.5e-06 25.6 0.1 0.015 15.8 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 VDK74731.1 - 1.8e-05 24.9 0.3 0.00025 21.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DKCLD PF08068.12 VDK74731.1 - 0.077 13.1 0.0 0.2 11.8 0.0 1.7 1 0 0 1 1 1 0 DKCLD (NUC011) domain MDFI PF15316.6 VDK74731.1 - 4.6 7.3 17.0 0.038 14.1 1.9 2.5 1 1 1 2 2 2 0 MyoD family inhibitor zf-C3HC4_2 PF13923.6 VDK74733.1 - 7.1e-12 45.0 13.6 1.5e-11 43.9 13.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK74733.1 - 1.1e-09 37.9 10.4 2.3e-09 37.0 10.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK74733.1 - 3.6e-07 30.4 12.2 7.1e-07 29.5 12.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK74733.1 - 2.1e-06 27.7 9.4 4.5e-06 26.6 9.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK74733.1 - 5.6e-06 26.1 10.3 9.3e-06 25.4 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK74733.1 - 0.0001 22.2 12.2 0.00022 21.1 12.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 VDK74733.1 - 0.00015 21.9 7.9 0.00029 20.9 7.9 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING BUD22 PF09073.10 VDK74733.1 - 0.0023 17.3 2.5 0.0036 16.7 2.5 1.2 1 0 0 1 1 1 1 BUD22 zf-Nse PF11789.8 VDK74733.1 - 0.0025 17.6 6.9 0.0051 16.6 6.9 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 VDK74733.1 - 0.0091 15.8 8.6 0.027 14.3 8.6 1.8 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 VDK74733.1 - 0.029 14.6 8.1 0.029 14.6 8.1 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_6 PF14835.6 VDK74733.1 - 0.061 13.2 6.2 0.12 12.3 6.2 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_5 PF17121.5 VDK74733.1 - 0.35 10.8 7.1 0.98 9.4 7.1 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK74733.1 - 0.93 9.4 10.9 1.6 8.7 8.8 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 HYLS1_C PF15311.6 VDK74735.1 - 2.6e-08 34.5 0.1 8.8e-08 32.8 0.1 1.9 1 0 0 1 1 1 1 Hydrolethalus syndrome protein 1 C-terminus PMI_typeI PF01238.21 VDK74736.1 - 7.1e-84 282.1 0.0 9.7e-84 281.7 0.0 1.2 1 0 0 1 1 1 1 Phosphomannose isomerase type I FYVE PF01363.21 VDK74739.1 - 4.8e-19 68.3 13.4 1.9e-18 66.3 13.4 2.2 1 0 0 1 1 1 1 FYVE zinc finger TagA PF12561.8 VDK74739.1 - 0.015 15.7 0.3 6.4 7.2 0.0 4.6 3 1 0 3 3 3 0 ToxR activated gene A lipoprotein domain Deltameth_res PF16020.5 VDK74739.1 - 0.22 11.4 0.1 0.45 10.4 0.1 1.5 1 0 0 1 1 1 0 Deltamethrin resistance IBR PF01485.21 VDK74739.1 - 0.34 11.1 11.1 0.094 13.0 6.3 2.6 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Zn-ribbon_8 PF09723.10 VDK74739.1 - 5.3 7.3 10.9 37 4.6 3.1 3.2 1 1 1 2 2 2 0 Zinc ribbon domain DZR PF12773.7 VDK74739.1 - 9.2 6.4 12.0 1.2e+02 2.8 12.0 2.6 1 1 0 1 1 1 0 Double zinc ribbon ShK PF01549.24 VDK74748.1 - 7.6e-14 52.0 25.3 1.6e-07 31.8 6.7 2.8 3 0 0 3 3 3 2 ShK domain-like adh_short PF00106.25 VDK74749.1 - 3.7e-33 114.6 0.0 1.5e-31 109.4 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK74749.1 - 1.7e-19 70.3 0.0 3.3e-18 66.1 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 VDK74749.1 - 4e-07 29.7 0.0 5.7e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 VDK74749.1 - 1.7e-06 28.1 0.0 3.7e-06 27.0 0.0 1.5 1 1 1 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 VDK74749.1 - 0.00012 21.6 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 VDK74749.1 - 0.044 13.1 0.0 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain zf-HC5HC2H_2 PF13832.6 VDK74750.1 - 1.3e-19 70.4 16.0 1.1e-17 64.2 0.1 3.7 3 0 0 3 3 3 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 VDK74750.1 - 5.1e-14 52.3 19.6 2.3e-10 40.6 0.1 4.0 3 0 0 3 3 3 3 PHD-like zinc-binding domain PHD PF00628.29 VDK74750.1 - 2.7e-13 49.6 42.5 1.6e-07 31.1 13.3 4.2 5 0 0 5 5 5 3 PHD-finger PHD_2 PF13831.6 VDK74750.1 - 0.00011 21.6 8.3 0.00011 21.6 8.3 5.1 5 2 0 5 5 5 1 PHD-finger Prok-RING_1 PF14446.6 VDK74750.1 - 0.00028 20.7 19.1 0.0021 17.9 1.5 3.9 3 0 0 3 3 3 2 Prokaryotic RING finger family 1 C1_1 PF00130.22 VDK74750.1 - 0.032 14.1 39.6 0.039 13.8 9.0 5.6 4 2 2 6 6 6 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FPRL1_inhibitor PF16104.5 VDK74750.1 - 0.057 13.6 0.1 0.88 9.7 0.0 2.9 3 0 0 3 3 3 0 Formyl peptide receptor-like 1 inhibitory protein DivIC PF04977.15 VDK74750.1 - 0.13 12.0 0.3 0.41 10.4 0.3 1.8 1 0 0 1 1 1 0 Septum formation initiator DUF1451 PF07295.11 VDK74750.1 - 3.2 7.8 10.3 0.25 11.4 1.1 2.9 2 0 0 2 2 2 0 Zinc-ribbon containing domain HALZ PF02183.18 VDK74750.1 - 8.2 6.7 10.2 15 5.9 7.4 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper zf-CHY PF05495.12 VDK74751.1 - 1.1e-12 48.2 13.5 1.1e-12 48.2 13.5 4.2 4 1 0 4 4 4 1 CHY zinc finger zf-CCCH_4 PF18044.1 VDK74751.1 - 2e-05 24.3 3.9 2e-05 24.3 3.9 2.6 2 0 0 2 2 2 1 CCCH-type zinc finger RWD PF05773.22 VDK74751.1 - 0.073 13.4 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 RWD domain Blt1_C PF17183.4 VDK74751.1 - 0.14 11.8 0.0 0.38 10.4 0.0 1.7 1 0 0 1 1 1 0 Get5 carboxyl domain RNase_PH PF01138.21 VDK74753.1 - 8.7e-26 91.0 0.4 1.3e-25 90.4 0.4 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 TGF_beta PF00019.20 VDK74754.1 - 8.2e-16 58.9 0.5 1.7e-15 57.9 0.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain DC_STAMP PF07782.13 VDK74756.1 - 2.9e-22 79.4 5.7 3.2e-12 46.7 0.0 3.4 2 2 1 3 3 3 2 DC-STAMP-like protein FOP_dimer PF09398.10 VDK74756.1 - 0.076 13.3 0.1 3.3 8.0 0.0 2.6 2 0 0 2 2 2 0 FOP N terminal dimerisation domain DUF1524 PF07510.11 VDK74757.1 - 0.11 12.4 0.2 6.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1524) Nop PF01798.18 VDK74759.1 - 3.3e-67 226.3 0.0 5.4e-67 225.6 0.0 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 VDK74759.1 - 8.8e-40 136.4 4.5 1.8e-39 135.4 4.5 1.6 1 0 0 1 1 1 1 Prp31 C terminal domain Yip1 PF04893.17 VDK74760.1 - 0.00011 21.9 7.8 0.00015 21.5 4.5 2.3 2 1 0 2 2 2 1 Yip1 domain DUF2157 PF09925.9 VDK74760.1 - 0.047 13.5 0.4 0.11 12.3 0.4 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) FBA PF04300.13 VDK74761.1 - 5.7e-49 166.2 0.0 4.7e-28 98.1 0.0 2.1 2 0 0 2 2 2 2 F-box associated region F-box-like PF12937.7 VDK74761.1 - 2.1e-05 24.3 0.2 4.7e-05 23.2 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 VDK74761.1 - 0.067 12.8 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 F-box F-box PF00646.33 VDK74761.1 - 0.16 11.9 0.5 0.64 10.0 0.5 2.0 1 1 0 1 1 1 0 F-box domain Itfg2 PF15907.5 VDK74764.1 - 9.7e-14 51.1 0.0 1.7e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 VDK74764.1 - 0.11 12.5 0.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Neur_chan_LBD PF02931.23 VDK74766.1 - 5.6e-41 140.4 0.4 7.4e-41 140.0 0.4 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK74766.1 - 2e-20 73.9 1.3 3.1e-18 66.7 1.0 2.1 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Caprin-1_dimer PF18293.1 VDK74767.1 - 7.8e-15 55.4 0.2 3.8e-14 53.2 0.0 2.2 2 1 0 2 2 2 1 Caprin-1 dimerization domain TrbM PF07424.11 VDK74767.1 - 0.028 14.4 0.8 0.074 13.0 0.8 1.6 1 0 0 1 1 1 0 TrbM RE_AlwI PF09491.10 VDK74767.1 - 1.2 7.9 17.7 0.8 8.4 4.7 3.0 2 1 1 3 3 3 0 AlwI restriction endonuclease FAM163 PF15069.6 VDK74767.1 - 3.7 8.0 9.8 0.33 11.4 4.3 1.9 2 0 0 2 2 2 0 FAM163 family Pkinase PF00069.25 VDK74768.1 - 4.1e-23 82.1 0.0 5.2e-23 81.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74768.1 - 2.3e-10 40.2 0.0 2.9e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK74768.1 - 5.2e-05 22.2 0.0 6.7e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK74768.1 - 0.0018 18.2 0.0 0.004 17.1 0.0 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 VDK74768.1 - 0.0078 15.9 0.0 2.1 7.9 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 VDK74768.1 - 0.04 13.3 0.0 0.056 12.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDI PF02234.19 VDK74774.1 - 9.5e-13 48.1 0.0 1.6e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor CDI PF02234.19 VDK74775.1 - 2.1e-06 27.8 0.6 4.7e-06 26.7 0.5 1.7 1 1 0 1 1 1 1 Cyclin-dependent kinase inhibitor WD40 PF00400.32 VDK74776.1 - 2.1e-22 79.0 6.8 0.00095 19.9 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 VDK74776.1 - 3.1e-06 26.1 3.0 0.023 13.4 0.1 3.2 2 1 1 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 VDK74776.1 - 0.0014 18.5 0.0 0.012 15.5 0.0 2.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 VDK74776.1 - 0.0024 18.1 0.2 5 7.5 0.0 4.0 2 2 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK74776.1 - 0.056 12.8 0.0 0.84 8.9 0.0 2.2 1 1 1 2 2 2 0 WD40-like domain Pkinase PF00069.25 VDK74777.1 - 2.6e-66 223.7 0.0 4.2e-66 223.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74777.1 - 7.8e-31 107.3 0.0 1.4e-30 106.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK74777.1 - 4.8e-06 26.1 0.3 0.00047 19.6 0.0 2.4 1 1 1 2 2 2 2 Kinase-like TDP43_N PF18694.1 VDK74778.1 - 2.6e-24 84.8 0.0 5e-24 83.9 0.0 1.5 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_1 PF00076.22 VDK74778.1 - 1.1e-15 57.2 0.7 1.3e-08 34.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MTES_1575 PF18741.1 VDK74779.1 - 0.12 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 REase_MTES_1575 NPL4 PF05021.15 VDK74780.1 - 1e-114 383.0 0.0 1.3e-114 382.7 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 VDK74780.1 - 8.7e-58 194.6 2.0 2e-57 193.4 2.0 1.6 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region zf-RanBP PF00641.18 VDK74780.1 - 0.016 14.5 4.3 0.016 14.5 4.3 3.0 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others HEAT PF02985.22 VDK74783.1 - 0.15 12.4 6.5 58 4.3 0.3 6.2 7 0 0 7 7 7 0 HEAT repeat ACDC PF14733.6 VDK74783.1 - 0.47 10.8 3.7 0.98 9.8 0.3 3.2 3 0 0 3 3 3 0 AP2-coincident C-terminal Kunitz_BPTI PF00014.23 VDK74798.1 - 1.1e-07 32.0 0.1 1.4e-07 31.6 0.1 1.2 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Kunitz_BPTI PF00014.23 VDK74801.1 - 5.1e-135 439.7 91.0 2e-17 63.1 3.2 10.8 11 0 0 11 11 11 10 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 VDK74801.1 - 4.6e-45 151.8 114.9 4.7e-09 36.5 7.9 9.1 9 0 0 9 9 9 7 Lustrin, cysteine-rich repeated domain AMP-binding PF00501.28 VDK74802.1 - 1.3e-52 178.8 0.0 3.8e-31 108.1 0.0 2.1 1 1 1 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 VDK74802.1 - 6.9e-12 46.2 0.9 6.9e-12 46.2 0.9 2.5 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain CX PF01705.19 VDK74803.1 - 3.4e-05 24.3 1.8 3.4e-05 24.3 1.8 1.6 2 0 0 2 2 2 1 CX module G-alpha PF00503.20 VDK74806.1 - 4.6e-88 295.8 6.7 9.9e-88 294.7 3.2 1.8 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 VDK74806.1 - 1.8e-12 47.1 1.1 8.5e-12 44.9 1.1 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK74806.1 - 0.00062 19.2 1.6 0.0012 18.3 1.6 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 VDK74806.1 - 0.095 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RPN7 PF10602.9 VDK74809.1 - 3.2e-37 127.9 2.0 6.3e-37 126.9 2.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 VDK74809.1 - 2.6e-15 56.8 2.6 4.4e-15 56.1 1.6 1.9 2 0 0 2 2 2 1 PCI domain SET PF00856.28 VDK74810.1 - 1.5e-22 80.8 0.3 6.6e-22 78.7 0.3 2.2 1 1 0 1 1 1 1 SET domain preSET_CXC PF18264.1 VDK74810.1 - 6.5e-10 39.3 20.3 6.5e-10 39.3 20.3 4.0 3 1 0 3 3 3 1 CXC domain Myb_DNA-binding PF00249.31 VDK74810.1 - 0.0062 16.7 1.2 0.38 11.0 0.0 3.6 4 0 0 4 4 4 1 Myb-like DNA-binding domain Cyclin_N PF00134.23 VDK74811.1 - 1.2e-12 47.7 0.0 2.9e-09 36.8 0.0 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 VDK74811.1 - 0.0013 18.8 0.1 1.6 8.9 0.0 2.9 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 VDK74811.1 - 0.0064 16.9 0.0 0.02 15.3 0.0 1.8 1 0 0 1 1 1 1 Cyclin C-terminal domain PulA_N1 PF17999.1 VDK74813.1 - 0.045 14.5 0.8 0.2 12.4 0.1 2.5 2 0 0 2 2 2 0 Pullulanase N1-terminal domain Sulfotransfer_1 PF00685.27 VDK74815.1 - 2.7e-55 187.7 0.1 4.8e-55 186.9 0.1 1.3 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 VDK74815.1 - 7.5e-10 39.6 0.1 1.5e-05 25.5 0.0 2.8 2 1 1 3 3 3 2 Sulfotransferase family Sulfotransfer_2 PF03567.14 VDK74815.1 - 0.013 15.4 0.6 0.023 14.6 0.6 1.5 1 1 0 1 1 1 0 Sulfotransferase family EF1_GNE PF00736.19 VDK74828.1 - 7.6e-32 109.4 3.9 7.6e-32 109.4 3.9 2.1 2 1 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 VDK74828.1 - 2.2e-11 44.0 4.7 2.2e-11 44.0 4.7 2.2 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region Cyclin_C_2 PF16899.5 VDK74828.1 - 0.027 14.8 0.3 0.36 11.2 0.0 2.7 3 0 0 3 3 3 0 Cyclin C-terminal domain MRP-S26 PF14943.6 VDK74828.1 - 0.054 13.4 3.3 0.1 12.5 3.3 1.5 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 MinC_N PF05209.13 VDK74828.1 - 0.067 13.2 0.0 0.22 11.5 0.0 2.0 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain DUF1043 PF06295.12 VDK74828.1 - 0.11 12.5 0.8 0.29 11.1 0.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) DUF1664 PF07889.12 VDK74828.1 - 0.24 11.4 0.1 0.24 11.4 0.1 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) DUF4404 PF14357.6 VDK74828.1 - 0.38 11.4 3.7 0.39 11.4 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) FlaC_arch PF05377.11 VDK74828.1 - 0.45 10.9 0.1 0.45 10.9 0.1 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DHR-2 PF06920.13 VDK74829.1 - 9.8e-89 298.4 0.0 4e-87 293.0 0.0 2.2 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 VDK74829.1 - 1.4e-40 139.2 0.1 2.5e-40 138.4 0.1 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 VDK74829.1 - 9.4e-16 58.2 0.0 2.9e-15 56.7 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PH PF00169.29 VDK74829.1 - 0.028 14.9 0.0 0.16 12.5 0.0 2.5 2 1 0 2 2 2 0 PH domain TP53IP5 PF15331.6 VDK74831.1 - 0.33 11.1 7.3 0.48 10.5 7.3 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 PBP1_TM PF14812.6 VDK74831.1 - 1.3 9.5 5.7 0.18 12.2 1.2 1.9 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Motile_Sperm PF00635.26 VDK74832.1 - 1.9e-07 30.9 0.1 5.5e-07 29.4 0.1 1.7 1 1 1 2 2 2 1 MSP (Major sperm protein) domain TPR_MLP1_2 PF07926.12 VDK74833.1 - 0.0029 17.7 22.2 0.0029 17.7 22.2 9.1 3 2 5 9 9 9 3 TPR/MLP1/MLP2-like protein CCDC92 PF14916.6 VDK74833.1 - 0.15 11.9 0.1 0.15 11.9 0.1 4.7 4 0 0 4 4 4 0 Coiled-coil domain of unknown function Phosphodiest PF01663.22 VDK74835.1 - 8.4e-70 236.1 0.3 3.3e-69 234.2 0.1 1.8 1 1 1 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase HpaB_N PF11794.8 VDK74835.1 - 0.024 14.3 0.0 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal UvrA_DNA-bind PF17755.1 VDK74835.1 - 0.15 12.4 0.0 0.37 11.2 0.0 1.5 1 0 0 1 1 1 0 UvrA DNA-binding domain Kinesin PF00225.23 VDK74837.1 - 5e-114 380.7 0.0 1e-113 379.7 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 VDK74837.1 - 4.1e-30 104.7 0.5 1.2e-29 103.2 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding DUF3694 PF12473.8 VDK74837.1 - 6.3e-27 95.1 0.0 8.8e-26 91.4 0.0 3.0 2 1 0 2 2 2 1 Kinesin protein Kinesin_assoc PF16183.5 VDK74837.1 - 4.1e-24 85.7 5.5 2.5e-16 60.3 0.5 3.3 1 1 1 2 2 2 2 Kinesin-associated KIF1B PF12423.8 VDK74837.1 - 1.8e-06 28.2 2.2 1.3e-05 25.5 2.2 2.5 1 1 0 1 1 1 1 Kinesin protein 1B FHA PF00498.26 VDK74837.1 - 0.00013 22.2 0.2 0.00092 19.5 0.1 2.6 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 VDK74837.1 - 0.00019 21.7 0.1 0.00063 20.0 0.1 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain C2-C2_1 PF11618.8 VDK74837.1 - 0.0027 17.8 0.4 0.25 11.4 0.0 3.1 3 0 0 3 3 3 1 First C2 domain of RPGR-interacting protein 1 Ead_Ea22 PF13935.6 VDK74837.1 - 0.11 13.2 4.5 3.9 8.1 1.4 3.0 3 0 0 3 3 3 0 Ead/Ea22-like protein Tsc35 PF15079.6 VDK74837.1 - 0.2 11.2 2.8 6.1 6.4 1.2 2.6 2 0 0 2 2 2 0 Testis-specific protein 35 GAS PF13851.6 VDK74837.1 - 0.92 8.8 13.6 0.11 11.8 6.9 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 VDK74837.1 - 2.4 8.9 8.6 16 6.2 3.9 3.4 3 0 0 3 3 2 0 Initiation control protein YabA TSC22 PF01166.18 VDK74837.1 - 4.1 7.8 5.4 17 5.8 5.1 2.3 2 0 0 2 2 1 0 TSC-22/dip/bun family Avl9 PF09794.9 VDK74848.1 - 2.4e-56 191.1 0.1 2.9e-56 190.8 0.1 1.1 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 VDK74848.1 - 1.1e-08 35.1 0.3 8.4e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 VDK74848.1 - 0.13 11.8 3.1 0.51 9.9 1.1 2.4 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 VDK74848.1 - 0.33 10.9 2.3 0.95 9.4 1.3 2.0 2 0 0 2 2 2 0 DENN (AEX-3) domain IMS PF00817.20 VDK74849.1 - 7.4e-37 126.7 0.1 7e-36 123.5 0.0 2.5 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 VDK74849.1 - 1.3e-10 42.0 0.0 5.5e-10 40.0 0.0 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 VDK74849.1 - 2e-08 34.5 0.1 2.2e-07 31.2 0.0 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 VDK74849.1 - 2e-06 28.1 0.0 5.7e-06 26.6 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 VDK74849.1 - 0.0064 16.8 0.0 0.016 15.5 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain Oberon_cc PF16312.5 VDK74849.1 - 0.033 14.1 1.6 0.075 13.0 1.6 1.6 1 0 0 1 1 1 0 Coiled-coil region of Oberon PTCB-BRCT PF12738.7 VDK74849.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 twin BRCT domain Skp1 PF01466.19 VDK74850.1 - 2.6e-30 104.3 0.7 4.7e-30 103.4 0.7 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 VDK74850.1 - 1.8e-22 79.3 0.9 4.8e-22 77.9 0.5 2.0 2 1 0 2 2 2 1 Skp1 family, tetramerisation domain E1_dh PF00676.20 VDK74851.1 - 1.2e-100 336.4 0.3 1.5e-100 336.1 0.3 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 VDK74851.1 - 5.7e-05 23.0 0.2 0.00052 19.8 0.3 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 VDK74851.1 - 9.7e-05 21.7 0.0 0.00053 19.3 0.0 2.0 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_N PF00456.21 VDK74851.1 - 0.0002 20.4 0.1 0.00042 19.4 0.0 1.5 2 0 0 2 2 2 1 Transketolase, thiamine diphosphate binding domain DUF155 PF02582.14 VDK74852.1 - 1e-36 126.7 0.1 1.5e-36 126.1 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 tRNA-synt_1c PF00749.21 VDK74853.1 - 9.9e-111 369.6 0.0 1.7e-110 368.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 VDK74853.1 - 1.8e-40 138.6 0.4 3.3e-40 137.7 0.4 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 VDK74853.1 - 1.8e-39 135.4 0.0 3.6e-39 134.4 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 VDK74853.1 - 6.6e-23 81.4 0.5 1.5e-22 80.4 0.5 1.6 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Rio2_N PF09202.11 VDK74853.1 - 0.028 14.6 0.0 0.32 11.2 0.0 2.7 2 0 0 2 2 2 0 Rio2, N-terminal SMC_N PF02463.19 VDK74855.1 - 6.5e-56 189.2 19.4 2.1e-55 187.6 19.4 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 VDK74855.1 - 2.7e-20 72.8 0.6 1.1e-19 70.9 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 VDK74855.1 - 5.4e-07 29.7 7.2 0.00016 21.6 0.0 3.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 VDK74855.1 - 0.00038 20.1 0.0 0.00094 18.9 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ADIP PF11559.8 VDK74855.1 - 0.0028 17.8 16.1 0.0028 17.8 16.1 9.0 4 2 4 8 8 8 2 Afadin- and alpha -actinin-Binding SbcCD_C PF13558.6 VDK74855.1 - 0.0067 16.6 0.0 0.036 14.3 0.0 2.3 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Flu_NS2 PF00601.19 VDK74858.1 - 0.13 12.6 0.1 0.3 11.4 0.1 1.5 1 0 0 1 1 1 0 Influenza non-structural protein (NS2) CCDC142 PF14923.6 VDK74863.1 - 0.057 12.2 0.2 0.1 11.3 0.2 1.3 1 0 0 1 1 1 0 Coiled-coil protein 142 ECM1 PF05782.11 VDK74863.1 - 2.4 7.0 8.9 0.73 8.7 3.2 2.1 1 1 1 2 2 2 0 Extracellular matrix protein 1 (ECM1) BTB_2 PF02214.22 VDK74883.1 - 4.6e-24 84.6 0.0 7.8e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 VDK74883.1 - 9.5e-07 29.0 0.0 1.7e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Ribosomal_S18 PF01084.20 VDK74884.1 - 3.4e-13 49.6 0.2 6.7e-13 48.6 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S18 RRM_1 PF00076.22 VDK74884.1 - 1.4e-09 37.6 0.0 2.7e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 VDK74884.1 - 7.6e-06 26.6 0.1 1.7e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 VDK74884.1 - 8.1e-06 25.7 1.9 8.1e-06 25.7 1.9 2.6 3 0 0 3 3 3 1 Zinc finger domain Nup35_RRM_2 PF14605.6 VDK74884.1 - 0.0041 17.1 0.0 0.0075 16.2 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif zf-CCCH_3 PF15663.5 VDK74884.1 - 0.0054 16.9 0.3 0.013 15.7 0.3 1.6 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 VDK74884.1 - 0.01 15.6 3.2 0.01 15.6 3.2 2.3 2 0 0 2 2 2 0 CCCH-type zinc finger zf-CCCH PF00642.24 VDK74884.1 - 0.01 15.7 3.5 0.01 15.7 3.5 2.6 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 VDK74884.1 - 0.014 15.8 1.1 0.014 15.8 1.1 3.0 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger FYVE PF01363.21 VDK74884.1 - 0.024 14.8 1.0 0.024 14.8 1.0 2.6 3 0 0 3 3 3 0 FYVE zinc finger Thioredoxin PF00085.20 VDK74885.1 - 6.3e-35 119.3 1.6 1.6e-19 69.8 0.3 2.1 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 VDK74885.1 - 7.2e-08 32.1 2.8 0.0001 21.8 0.1 2.0 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 VDK74885.1 - 8.6e-06 26.2 1.7 0.049 14.1 0.1 2.7 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_3 PF13192.6 VDK74885.1 - 0.00085 19.3 0.0 0.12 12.5 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_7 PF13899.6 VDK74885.1 - 0.0011 19.1 0.5 0.19 12.0 0.3 2.3 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 VDK74885.1 - 0.026 14.9 0.1 0.52 10.7 0.1 2.5 2 1 0 2 2 2 0 Thioredoxin-like AhpC-TSA PF00578.21 VDK74885.1 - 0.11 12.5 0.9 0.27 11.2 0.3 1.9 2 0 0 2 2 2 0 AhpC/TSA family Glutaredoxin PF00462.24 VDK74885.1 - 0.13 12.5 6.3 1.1 9.5 0.5 3.1 2 2 0 2 2 2 0 Glutaredoxin JmjC PF02373.22 VDK74886.1 - 2.3e-13 50.5 0.1 7.3e-13 49.0 0.1 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 VDK74886.1 - 0.034 13.9 0.2 0.19 11.4 0.0 2.3 3 0 0 3 3 3 0 Cupin-like domain FYVE PF01363.21 VDK74886.1 - 0.081 13.1 5.6 0.27 11.4 5.6 1.9 1 0 0 1 1 1 0 FYVE zinc finger PLATZ PF04640.14 VDK74886.1 - 3.4 8.4 7.1 9.2 7.0 1.7 3.3 3 0 0 3 3 3 0 PLATZ transcription factor Pkinase PF00069.25 VDK74888.1 - 5.8e-53 179.9 0.0 7.3e-53 179.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74888.1 - 3.4e-25 88.8 0.0 5.3e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK74888.1 - 0.002 17.5 0.0 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 VDK74888.1 - 0.061 12.3 0.0 0.08 11.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Cadherin PF00028.17 VDK74890.1 - 1.7e-128 419.4 13.7 1e-19 70.8 0.1 10.0 10 0 0 10 10 10 8 Cadherin domain Laminin_G_2 PF02210.24 VDK74890.1 - 8.5e-17 61.9 0.0 1.5e-12 48.2 0.0 3.1 2 1 0 2 2 2 2 Laminin G domain Cadherin_2 PF08266.12 VDK74890.1 - 7.5e-13 48.1 1.0 0.21 11.4 0.1 6.3 6 0 0 6 6 6 5 Cadherin-like Laminin_G_1 PF00054.23 VDK74890.1 - 2.1e-09 37.7 0.0 1.2e-05 25.5 0.0 3.1 2 1 0 2 2 2 2 Laminin G domain Cadherin_3 PF16184.5 VDK74890.1 - 6.6e-09 35.7 11.8 5.2 7.1 0.1 8.6 9 0 0 9 9 9 3 Cadherin-like EGF PF00008.27 VDK74890.1 - 8.1e-05 22.8 7.4 8.1e-05 22.8 7.4 8.7 9 1 0 9 9 9 4 EGF-like domain RET_CLD1 PF17756.1 VDK74890.1 - 0.00013 22.3 0.0 62 3.9 0.0 6.2 7 0 0 7 7 7 0 RET Cadherin like domain 1 Cadherin_4 PF17803.1 VDK74890.1 - 0.013 16.1 17.8 0.47 11.1 0.1 6.4 6 0 0 6 6 6 0 Bacterial cadherin-like domain hEGF PF12661.7 VDK74890.1 - 0.11 13.2 0.1 0.026 15.2 3.8 9.0 7 1 1 8 8 8 0 Human growth factor-like EGF Big_9 PF17963.1 VDK74890.1 - 0.46 11.3 11.7 5.9 7.7 0.2 4.2 3 0 0 3 3 3 0 Bacterial Ig domain PDZ PF00595.24 VDK74891.1 - 2.1e-60 201.0 12.7 8.7e-17 61.3 0.0 5.0 5 0 0 5 5 5 4 PDZ domain PDZ_6 PF17820.1 VDK74891.1 - 3.3e-44 148.5 13.6 7.7e-12 44.9 0.3 4.7 5 0 0 5 5 5 4 PDZ domain PDZ_2 PF13180.6 VDK74891.1 - 4.6e-22 78.1 1.0 0.00012 22.3 0.4 4.9 4 1 1 5 5 5 4 PDZ domain WW PF00397.26 VDK74891.1 - 1e-16 60.7 10.5 7.2e-11 42.0 1.7 2.9 3 0 0 3 3 3 2 WW domain GRASP55_65 PF04495.14 VDK74891.1 - 0.14 12.5 0.0 11 6.3 0.0 2.8 3 0 0 3 3 3 0 GRASP55/65 PDZ-like domain Guanylate_kin PF00625.21 VDK74892.1 - 7.7e-09 35.5 0.0 1.5e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Guanylate kinase PDZ_6 PF17820.1 VDK74892.1 - 0.00023 20.9 0.1 0.00084 19.1 0.1 1.9 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDK74892.1 - 0.0091 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Pkinase PF00069.25 VDK74897.1 - 9e-73 244.9 0.0 1e-72 244.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74897.1 - 5e-34 117.8 0.0 7.6e-34 117.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK74897.1 - 0.00021 20.3 0.1 0.00041 19.4 0.1 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 VDK74897.1 - 0.00023 20.6 0.0 0.001 18.5 0.0 1.8 1 1 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 VDK74897.1 - 0.00043 19.5 0.0 0.00064 18.9 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 RIO1 PF01163.22 VDK74897.1 - 0.0018 17.9 0.0 0.0029 17.2 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 VDK74897.1 - 0.0032 17.4 0.0 0.0083 16.1 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 VDK74897.1 - 0.02 14.2 0.5 0.1 12.0 0.5 2.0 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mannosyl_trans2 PF04188.13 VDK74909.1 - 1.1e-49 170.0 42.9 5.6e-49 167.7 42.9 2.2 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) eIF2_C PF09173.11 VDK74912.1 - 7.2e-37 125.5 0.5 1.7e-36 124.4 0.5 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 VDK74912.1 - 1.7e-22 79.9 0.2 1.1e-21 77.3 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 VDK74912.1 - 4.7e-11 42.9 0.4 2.4e-10 40.6 0.4 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 VDK74912.1 - 0.0014 18.6 0.3 0.17 11.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 VDK74912.1 - 0.0017 18.4 0.0 0.0034 17.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DNA_ligase_ZBD PF03119.16 VDK74912.1 - 0.059 13.4 0.1 0.059 13.4 0.1 2.6 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain G-alpha PF00503.20 VDK74912.1 - 0.061 12.5 0.1 0.22 10.6 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit MMR_HSR1_Xtn PF16897.5 VDK74912.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Inositol_P PF00459.25 VDK74914.1 - 1.3e-71 241.3 0.0 1.5e-71 241.1 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family Tctex-1 PF03645.13 VDK74915.1 - 3.8e-24 84.9 3.5 4.4e-24 84.7 3.5 1.0 1 0 0 1 1 1 1 Tctex-1 family DUF4668 PF15701.5 VDK74917.1 - 0.014 15.3 4.3 0.1 12.4 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4668) DUF2207 PF09972.9 VDK74917.1 - 0.056 12.2 7.1 0.22 10.2 0.8 2.6 1 1 2 3 3 3 0 Predicted membrane protein (DUF2207) Claudin_3 PF06653.11 VDK74917.1 - 0.99 9.3 10.6 0.16 11.9 3.4 2.8 2 1 0 2 2 2 0 Tight junction protein, Claudin-like Vinculin PF01044.19 VDK74918.1 - 7.2e-74 249.6 9.6 6.1e-40 137.3 2.4 3.1 2 1 1 3 3 3 3 Vinculin family DUF1798 PF08807.10 VDK74918.1 - 3.8 7.7 5.9 13 6.0 0.1 3.5 5 0 0 5 5 5 0 Bacterial domain of unknown function (DUF1798) GIT1_C PF12205.8 VDK74918.1 - 5.3 7.2 6.9 17 5.5 0.1 4.3 3 2 2 5 5 5 0 G protein-coupled receptor kinase-interacting protein 1 C term Laminin_EGF PF00053.24 VDK74919.1 - 1.4e-22 79.5 301.5 0.00029 20.9 15.6 17.5 6 4 10 16 16 16 10 Laminin EGF domain DSL PF01414.19 VDK74919.1 - 0.0039 17.4 34.4 0.0048 17.1 14.4 16.7 14 3 2 16 16 16 6 Delta serrate ligand EMI PF07546.13 VDK74920.1 - 0.00032 21.4 1.5 0.00032 21.4 1.5 2.3 2 1 0 2 2 2 1 EMI domain Ras PF00071.22 VDK74921.1 - 1e-50 171.5 0.0 1.3e-50 171.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK74921.1 - 7.5e-30 103.6 0.0 2.2e-29 102.1 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK74921.1 - 3.2e-15 56.0 0.0 4.4e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK74921.1 - 6.7e-06 26.1 0.0 0.036 14.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 VDK74921.1 - 2.4e-05 24.4 0.0 4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK74921.1 - 0.0032 16.9 0.0 0.0057 16.0 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 VDK74921.1 - 0.018 15.3 0.2 0.29 11.4 0.2 2.3 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 VDK74921.1 - 0.023 14.2 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 VDK74921.1 - 0.057 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 VDK74921.1 - 0.1 11.6 0.1 0.21 10.5 0.0 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ERO1 PF04137.15 VDK74922.1 - 4e-113 378.2 0.0 4.9e-113 377.9 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) RNase_Zc3h12a PF11977.8 VDK74924.1 - 5.3e-31 107.5 0.0 6.2e-31 107.3 0.0 1.0 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain Frizzled PF01534.17 VDK74927.1 - 1.2e-103 346.6 22.7 1.6e-103 346.1 22.7 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 VDK74927.1 - 2.7e-31 108.4 2.3 2.7e-31 108.4 2.3 2.1 2 0 0 2 2 2 1 Fz domain Dicty_CAR PF05462.11 VDK74927.1 - 2.2e-06 27.0 10.0 2.2e-06 27.0 10.0 2.0 2 1 1 3 3 3 1 Slime mold cyclic AMP receptor DUF2649 PF10854.8 VDK74927.1 - 0.74 10.2 6.0 0.76 10.1 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2649) Tetraspanin PF00335.20 VDK74929.1 - 3.8e-36 124.9 11.4 4.4e-36 124.7 11.4 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF2157 PF09925.9 VDK74929.1 - 0.006 16.4 0.8 0.0099 15.7 0.7 1.6 1 1 0 1 1 1 1 Predicted membrane protein (DUF2157) Astacin PF01400.24 VDK74950.1 - 1.5e-64 217.1 0.6 3.3e-64 216.0 0.6 1.6 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Endopep_inhib PF16800.5 VDK74950.1 - 0.043 13.7 0.3 0.043 13.7 0.3 2.0 2 0 0 2 2 2 0 IseA DL-endopeptidase inhibitor HSP20 PF00011.21 VDK74951.1 - 8.7e-22 77.2 0.1 1.2e-21 76.7 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK74951.1 - 0.0041 16.6 0.0 0.0075 15.8 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Nucleotid_trans PF03407.16 VDK74952.1 - 5.6e-10 39.6 0.0 7.2e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Folate_carrier PF01770.18 VDK74954.1 - 1.8e-126 422.3 32.9 2.1e-126 422.0 32.9 1.1 1 0 0 1 1 1 1 Reduced folate carrier JAB PF01398.21 VDK74955.1 - 4.4e-32 110.5 0.2 9.9e-32 109.4 0.0 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 VDK74955.1 - 3.8e-14 53.0 1.2 3.8e-14 53.0 1.2 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 VDK74955.1 - 4.4e-06 26.5 0.0 7.3e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain SAM_1 PF00536.30 VDK74955.1 - 0.015 15.8 0.5 0.039 14.4 0.5 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) LIDHydrolase PF10230.9 VDK74956.1 - 3.1e-55 187.6 0.0 3.6e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 VDK74956.1 - 6.8e-05 23.6 0.0 8.2e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 VDK74956.1 - 0.015 14.8 0.0 0.039 13.5 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 VDK74956.1 - 0.067 12.9 0.2 0.16 11.6 0.2 1.6 1 1 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 VDK74956.1 - 0.094 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 VDK74956.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2235 PF09994.9 VDK74956.1 - 0.2 11.0 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Pkinase PF00069.25 VDK74957.1 - 9.6e-64 215.3 0.0 1.2e-63 214.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74957.1 - 8.5e-28 97.3 0.0 1.2e-27 96.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK74957.1 - 9e-05 21.6 0.2 0.00013 21.1 0.2 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 VDK74957.1 - 0.11 11.2 0.1 0.27 10.0 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase ACOX PF01756.19 VDK74958.1 - 1.6e-30 106.0 0.0 2.9e-30 105.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 VDK74958.1 - 4.7e-09 36.3 0.0 7.9e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 VDK74958.1 - 1.8e-05 25.0 0.1 8.7e-05 22.8 0.1 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Vac7 PF12751.7 VDK74959.1 - 0.0087 15.5 0.1 0.013 15.0 0.1 1.1 1 0 0 1 1 1 1 Vacuolar segregation subunit 7 Mu-like_Com PF10122.9 VDK74959.1 - 0.081 12.4 0.1 1.1 8.8 0.0 2.3 2 0 0 2 2 2 0 Mu-like prophage protein Com PriA_CRR PF18319.1 VDK74959.1 - 0.33 11.0 3.2 0.21 11.6 0.9 2.0 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain Suv3_N PF18114.1 VDK74960.1 - 5.8e-34 116.7 0.0 3.1e-33 114.4 0.0 2.4 1 0 0 1 1 1 1 Suv3 helical N-terminal domain SUV3_C PF12513.8 VDK74960.1 - 6.8e-16 57.9 0.6 2.8e-15 56.0 0.6 2.1 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Nucleoporin_C PF03177.14 VDK74960.1 - 3.9e-13 49.0 0.4 7.4e-13 48.1 0.4 1.4 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Suv3_C_1 PF18147.1 VDK74960.1 - 1e-11 44.5 0.1 3.7e-11 42.7 0.1 2.1 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 VDK74960.1 - 4.6e-08 33.4 0.0 1.7e-07 31.5 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Nucleoporin_N PF08801.11 VDK74960.1 - 0.00017 20.5 0.2 0.00035 19.4 0.2 1.5 1 1 0 1 1 1 1 Nup133 N terminal like Fcf1 PF04900.12 VDK74961.1 - 1.1e-25 89.8 0.4 2.2e-25 88.9 0.4 1.5 1 0 0 1 1 1 1 Fcf1 CX9C PF16860.5 VDK74962.1 - 0.00063 19.7 0.7 0.0037 17.3 0.7 2.1 1 1 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, AGA2 PF17366.2 VDK74962.1 - 0.057 13.1 0.3 0.096 12.4 0.3 1.4 1 0 0 1 1 1 0 A-agglutinin-binding subunit Aga2 Peroxin-3 PF04882.12 VDK74963.1 - 1.1e-20 74.1 1.8 5.8e-11 42.1 0.5 2.9 1 1 1 2 2 2 2 Peroxin-3 IF4E PF01652.18 VDK74964.1 - 5.2e-49 166.1 0.9 7e-49 165.7 0.9 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Pkinase PF00069.25 VDK74965.1 - 5.5e-26 91.5 0.0 7.6e-26 91.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK74965.1 - 1.8e-15 56.9 0.0 2.7e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK74965.1 - 0.024 14.6 0.0 0.26 11.2 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 VDK74965.1 - 0.08 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Fructosamine kinase Pkinase_fungal PF17667.1 VDK74965.1 - 0.17 10.6 3.9 0.054 12.3 0.2 1.8 2 1 0 2 2 2 0 Fungal protein kinase ATP_synt_H PF05493.13 VDK74970.1 - 6.4e-25 87.4 9.8 9.3e-25 86.9 9.8 1.3 1 0 0 1 1 1 1 ATP synthase subunit H Proteasome PF00227.26 VDK74972.1 - 9.5e-46 155.7 0.0 1.2e-45 155.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 VDK74972.1 - 2.2e-12 46.4 0.1 6.2e-12 45.0 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF1525 PF07511.11 VDK74972.1 - 0.11 12.7 0.0 0.84 9.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) HSP70 PF00012.20 VDK74974.1 - 2e-264 878.4 12.1 2.3e-264 878.1 12.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 VDK74974.1 - 2e-17 63.0 0.8 1.2e-15 57.2 0.1 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 VDK74974.1 - 0.00098 19.5 1.7 2.4 8.7 0.0 3.3 3 1 0 3 3 3 2 Cell division protein FtsA Hydantoinase_A PF01968.18 VDK74974.1 - 0.0092 15.3 1.2 0.14 11.4 0.1 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase MCLC PF05934.11 VDK74974.1 - 0.064 12.0 0.0 0.11 11.2 0.0 1.3 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) FGGY_C PF02782.16 VDK74974.1 - 0.079 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Radial_spoke_3 PF06098.11 VDK74974.1 - 3.4 6.8 10.4 0.056 12.7 2.3 1.9 2 0 0 2 2 2 0 Radial spoke protein 3 TFIIS_C PF01096.18 VDK74976.1 - 2.1e-19 69.1 3.2 2.1e-19 69.1 3.2 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 VDK74976.1 - 1e-06 28.5 4.2 1e-06 28.5 4.2 1.9 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 VDK74976.1 - 0.01 15.8 1.6 0.01 15.8 1.6 2.7 2 2 0 2 2 2 0 Transposase zinc-ribbon domain PH_17 PF18012.1 VDK74976.1 - 0.043 13.5 0.1 0.098 12.4 0.1 1.5 1 1 0 1 1 1 0 PH domain zinc-ribbons_6 PF07191.12 VDK74976.1 - 0.054 13.5 1.9 0.054 13.5 1.9 2.3 2 1 0 2 2 2 0 zinc-ribbons Ogr_Delta PF04606.12 VDK74976.1 - 0.15 12.0 13.1 0.1 12.6 2.3 3.2 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger zinc_ribbon_2 PF13240.6 VDK74976.1 - 0.27 11.0 0.2 0.27 11.0 0.2 3.4 3 1 0 3 3 3 0 zinc-ribbon domain zf-TFIIB PF13453.6 VDK74976.1 - 0.33 10.3 6.7 4.2 6.8 0.0 2.7 2 1 0 2 2 2 0 Transcription factor zinc-finger A2L_zn_ribbon PF08792.10 VDK74976.1 - 0.33 10.7 0.2 0.33 10.7 0.2 2.6 3 0 0 3 3 2 0 A2L zinc ribbon domain Zn_ribbon_recom PF13408.6 VDK74976.1 - 0.48 11.0 7.2 0.36 11.4 0.6 2.3 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain DZR PF12773.7 VDK74976.1 - 0.96 9.5 12.6 5.2 7.2 10.0 2.4 1 1 1 2 2 2 0 Double zinc ribbon HypA PF01155.19 VDK74976.1 - 1.4 9.0 5.6 28 4.8 5.6 2.3 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Nudix_N_2 PF14803.6 VDK74976.1 - 2.1 8.3 9.7 1 9.4 4.0 2.7 3 0 0 3 3 3 0 Nudix N-terminal TF_Zn_Ribbon PF08271.12 VDK74976.1 - 2.2 7.9 11.4 0.76 9.3 4.6 2.4 2 1 0 2 2 2 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 VDK74976.1 - 3.1 8.0 16.2 5.7 7.1 0.1 4.3 3 1 2 5 5 5 0 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 VDK74976.1 - 6.3 6.9 16.4 7.1 6.7 6.1 3.4 3 1 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain PhnA_Zn_Ribbon PF08274.12 VDK74976.1 - 8.1 6.5 12.6 6.9 6.7 0.5 3.5 2 2 0 2 2 2 0 PhnA Zinc-Ribbon T6PP_N PF18572.1 VDK74990.1 - 2.7e-26 91.3 3.6 6.2e-26 90.2 3.6 1.6 1 0 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain zf-FCS PF06467.14 VDK74990.1 - 0.031 14.2 0.4 0.25 11.3 0.3 2.4 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Spore_III_AB PF09548.10 VDK74990.1 - 0.85 9.7 6.2 0.24 11.5 1.4 2.2 1 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Peptidase_S8 PF00082.22 VDK74993.1 - 1.7e-42 145.7 1.1 3.9e-42 144.6 0.2 1.9 2 0 0 2 2 2 1 Subtilase family DNA_topoisoIV PF00521.20 VDK74994.1 - 1.4e-124 416.3 0.3 1.4e-124 416.3 0.3 2.0 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 VDK74994.1 - 2.5e-49 166.8 5.6 2.5e-49 166.8 5.6 3.6 3 1 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 VDK74994.1 - 3.8e-24 85.1 1.5 9.9e-24 83.8 1.5 1.8 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 VDK74994.1 - 9.6e-14 51.8 0.0 2.6e-13 50.4 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 VDK74994.1 - 6.6e-07 29.5 0.0 2.9e-06 27.4 0.0 2.2 1 0 0 1 1 1 1 Toprim domain DUF5104 PF17117.5 VDK74994.1 - 0.014 15.8 1.6 3 8.3 0.2 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5104) DNA_gyraseB_C PF00986.21 VDK74994.1 - 1.2 9.4 8.2 0.067 13.4 0.4 2.9 3 0 0 3 3 3 0 DNA gyrase B subunit, carboxyl terminus Mitoc_mL59 PF18126.1 VDK74995.1 - 0.0054 17.0 0.7 0.01 16.2 0.7 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 CDC45 PF02724.14 VDK74995.1 - 0.55 8.5 8.9 0.79 7.9 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RasGAP PF00616.19 VDK74996.1 - 1.6e-23 83.5 5.6 1.1e-13 51.4 0.2 2.9 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase Spectrin PF00435.21 VDK74996.1 - 0.33 11.4 5.0 0.1 13.1 1.7 1.8 2 0 0 2 2 2 0 Spectrin repeat CENP-B_dimeris PF09026.10 VDK74996.1 - 0.82 10.1 12.4 2.4 8.6 12.4 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DivIC PF04977.15 VDK74996.1 - 0.9 9.3 3.1 2.1 8.2 3.1 1.6 1 0 0 1 1 1 0 Septum formation initiator DNA_pol_phi PF04931.13 VDK74996.1 - 3.2 5.7 11.7 68 1.3 13.1 2.0 2 0 0 2 2 2 0 DNA polymerase phi Spt5_N PF11942.8 VDK74996.1 - 8.7 7.4 14.8 2.1 9.4 10.1 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal C2 PF00168.30 VDK74997.1 - 1.2e-09 38.4 0.0 1.3e-09 38.2 0.0 1.0 1 0 0 1 1 1 1 C2 domain zf-met PF12874.7 VDK74997.1 - 0.092 13.2 0.2 0.19 12.2 0.2 1.6 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Chorion_2 PF03964.15 VDK74999.1 - 0.014 16.2 10.3 0.026 15.4 10.3 1.4 1 0 0 1 1 1 0 Chorion family 2 T4_tail_cap PF11091.8 VDK74999.1 - 0.14 11.1 4.4 0.2 10.5 4.4 1.2 1 0 0 1 1 1 0 Tail-tube assembly protein SR-25 PF10500.9 VDK74999.1 - 0.22 11.1 19.5 0.34 10.5 19.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4171 PF13775.6 VDK74999.1 - 2.4 8.6 19.3 4.5 7.7 17.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) IMUP PF15761.5 VDK74999.1 - 3.5 8.4 22.2 7.5 7.3 22.2 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein AF-4 PF05110.13 VDK74999.1 - 6 4.8 16.1 5.6 4.9 16.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Keratin_2_head PF16208.5 VDK74999.1 - 7.8 6.6 11.0 11 6.2 11.0 1.2 1 0 0 1 1 1 0 Keratin type II head DUF1635 PF07795.11 VDK74999.1 - 8.1 6.2 7.1 15 5.4 7.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Lipase_GDSL PF00657.22 VDK75024.1 - 1.2e-07 31.9 0.0 2e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase GYD PF08734.11 VDK75024.1 - 0.17 11.9 0.0 0.42 10.6 0.0 1.6 1 0 0 1 1 1 0 GYD domain DUF4604 PF15377.6 VDK75025.1 - 5.2e-08 33.5 8.9 2e-06 28.3 8.9 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4604) Atg14 PF10186.9 VDK75025.1 - 0.041 13.0 2.7 0.045 12.8 2.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PgaPase_1 PF06162.12 VDK75026.1 - 1.7e-10 40.9 0.1 2.4e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Putative pyroglutamyl peptidase PgaPase_1 Peptidase_C15 PF01470.17 VDK75026.1 - 2.2e-06 28.0 0.0 2.8e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Pyroglutamyl peptidase Scs3p PF10261.9 VDK75028.1 - 1.8e-25 89.9 25.7 3.3e-22 79.2 25.7 3.1 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 VDK75028.1 - 1.8 8.3 12.7 0.22 11.3 6.0 2.3 1 1 1 2 2 2 0 PAP2 superfamily NmrA PF05368.13 VDK75034.1 - 6.8e-13 48.7 0.0 9.3e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 VDK75034.1 - 1.9e-12 47.4 0.0 2.8e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 VDK75034.1 - 6.8e-11 42.1 0.0 9.9e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 VDK75034.1 - 1.8e-10 40.4 0.0 4.1e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 VDK75034.1 - 9.1e-06 24.9 0.0 2.8e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 VDK75034.1 - 1.6e-05 24.2 0.3 0.063 12.4 0.0 3.0 2 1 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 VDK75034.1 - 0.023 13.8 0.0 0.043 13.0 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 VDK75034.1 - 0.029 13.8 0.0 0.078 12.4 0.0 1.7 1 1 1 2 2 2 0 short chain dehydrogenase DUF3798 PF12683.7 VDK75034.1 - 0.061 12.7 0.1 0.14 11.5 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3798) KR PF08659.10 VDK75034.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 2 0 0 2 2 2 0 KR domain Peptidase_M14 PF00246.24 VDK75035.1 - 2.7e-17 63.5 0.0 6.4e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 VDK75035.1 - 5.8e-10 39.5 0.3 1.6e-09 38.1 0.3 1.8 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Vac14_Fab1_bd PF12755.7 VDK75035.1 - 0.26 11.9 2.5 0.42 11.2 1.1 2.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Homeodomain PF00046.29 VDK75036.1 - 6.8e-23 80.3 5.4 9.8e-23 79.8 5.4 1.2 1 0 0 1 1 1 1 Homeodomain Nup_retrotrp_bd PF10599.9 VDK75036.1 - 0.027 15.1 0.6 0.054 14.2 0.6 1.5 1 0 0 1 1 1 0 Retro-transposon transporting motif GCV_H PF01597.19 VDK75037.1 - 1.5e-38 131.4 0.2 1.8e-38 131.1 0.2 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein DIE2_ALG10 PF04922.12 VDK75038.1 - 4.4e-09 36.1 2.2 4.4e-09 36.1 2.2 1.5 2 0 0 2 2 2 1 DIE2/ALG10 family CHGN PF05679.16 VDK75039.1 - 2e-147 492.2 0.0 4.7e-147 490.9 0.0 1.5 1 1 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 VDK75039.1 - 8e-16 58.2 0.0 1.3e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Glyco_transf_7C PF02709.14 VDK75039.1 - 1.7e-09 37.2 0.0 5.1e-09 35.7 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 VDK75039.1 - 4.3e-05 23.1 0.2 0.00036 20.1 0.2 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 VDK75039.1 - 0.015 15.1 0.4 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 Galactosyl_T PF01762.21 VDK75039.1 - 0.015 15.1 0.1 0.19 11.6 0.1 2.3 2 1 0 2 2 2 0 Galactosyltransferase Glyco_transf_21 PF13506.6 VDK75039.1 - 0.038 13.5 0.0 0.31 10.5 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 21 DUF4149 PF13664.6 VDK75039.1 - 0.052 13.9 0.2 0.11 12.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) Pkinase PF00069.25 VDK75040.1 - 9.9e-32 110.3 0.0 1.1e-14 54.5 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK75040.1 - 6e-17 61.8 0.0 2.6e-08 33.5 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase DEAD PF00270.29 VDK75041.1 - 2.4e-52 177.2 0.0 4e-52 176.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK75041.1 - 7.7e-26 90.6 0.0 1.3e-24 86.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SPRY PF00622.28 VDK75041.1 - 6.7e-23 81.1 0.1 1.2e-22 80.3 0.1 1.4 1 0 0 1 1 1 1 SPRY domain LIM PF00412.22 VDK75042.1 - 4.2e-32 110.1 40.0 5.9e-12 45.6 9.1 3.7 3 0 0 3 3 3 3 LIM domain SOUL PF04832.12 VDK75057.1 - 0.053 13.7 0.1 0.069 13.3 0.1 1.1 1 0 0 1 1 1 0 SOUL heme-binding protein Syndecan PF01034.20 VDK75058.1 - 9e-27 92.8 0.1 1.4e-26 92.2 0.1 1.2 1 0 0 1 1 1 1 Syndecan domain Glycophorin_A PF01102.18 VDK75058.1 - 0.0015 18.8 0.2 0.0017 18.6 0.2 1.2 1 0 0 1 1 1 1 Glycophorin A 5TM-5TMR_LYT PF07694.12 VDK75058.1 - 0.0024 17.4 0.2 0.0025 17.3 0.2 1.2 1 0 0 1 1 1 1 5TMR of 5TMR-LYT DUF4118 PF13493.6 VDK75058.1 - 0.014 15.2 0.9 0.021 14.6 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4118) Herpes_US9 PF06072.11 VDK75058.1 - 0.015 15.2 0.1 0.03 14.2 0.1 1.6 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 NEMP PF10225.9 VDK75058.1 - 0.029 14.1 0.5 0.044 13.5 0.5 1.2 1 0 0 1 1 1 0 NEMP family DUF5385 PF17359.2 VDK75058.1 - 0.17 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) FeoB_associated PF12669.7 VDK75058.1 - 0.18 12.2 2.6 0.44 11.0 2.6 1.7 1 1 0 1 1 1 0 FeoB-associated Cys-rich membrane protein UNC45-central PF11701.8 VDK75059.1 - 2.9e-30 105.3 0.7 7.4e-28 97.4 0.0 3.5 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central TPR_1 PF00515.28 VDK75059.1 - 1.1e-14 53.5 2.6 2.4e-05 24.0 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK75059.1 - 1e-11 44.0 9.1 5.7e-05 22.9 0.3 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK75059.1 - 3.6e-07 29.9 5.0 0.035 14.3 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK75059.1 - 5.6e-05 22.7 2.7 0.018 14.7 0.3 3.6 2 1 1 3 3 3 1 TPR repeat TPR_9 PF13371.6 VDK75059.1 - 0.00017 21.7 2.0 0.037 14.2 1.3 3.6 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK75059.1 - 0.00087 19.9 8.5 0.25 12.2 0.5 4.6 4 0 0 4 4 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 VDK75059.1 - 0.0021 18.1 1.1 0.015 15.4 0.1 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 VDK75059.1 - 0.0046 17.2 11.8 0.014 15.7 0.1 5.0 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK75059.1 - 0.026 15.2 8.7 0.13 13.0 0.0 3.6 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK75059.1 - 0.029 14.7 0.7 14 6.3 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK75059.1 - 0.061 14.0 8.2 0.26 12.0 0.4 4.4 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF3361 PF11841.8 VDK75059.1 - 0.064 13.2 3.3 0.54 10.2 0.1 3.0 4 0 0 4 4 3 0 Domain of unknown function (DUF3361) TPR_7 PF13176.6 VDK75059.1 - 0.59 10.3 5.8 4.3 7.6 0.0 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK75059.1 - 1.7 9.2 6.9 2.8 8.5 0.0 4.4 5 1 0 5 5 4 0 Tetratricopeptide repeat Lustrin_cystein PF14625.6 VDK75063.1 - 7.7e-68 224.6 259.9 4.4e-08 33.4 8.0 18.3 19 2 2 21 21 21 16 Lustrin, cysteine-rich repeated domain Kunitz_BPTI PF00014.23 VDK75063.1 - 1.5e-40 137.2 50.4 5.3e-15 55.4 6.5 6.2 5 0 0 5 5 5 3 Kunitz/Bovine pancreatic trypsin inhibitor domain cEGF PF12662.7 VDK75063.1 - 0.023 14.6 0.3 0.023 14.6 0.3 10.1 10 0 0 10 10 10 0 Complement Clr-like EGF-like NT-C2 PF10358.9 VDK75065.1 - 1.9e-26 92.5 0.0 2.7e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins zf-U1 PF06220.12 VDK75066.1 - 2e-06 27.4 0.1 4e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 U1 zinc finger WW PF00397.26 VDK75066.1 - 8.6e-06 25.7 0.3 2.1e-05 24.5 0.3 1.7 1 0 0 1 1 1 1 WW domain DivIC PF04977.15 VDK75066.1 - 1.6 8.6 7.4 0.45 10.3 0.9 2.4 2 0 0 2 2 2 0 Septum formation initiator Ncstrn_small PF18266.1 VDK75068.1 - 0.015 15.3 1.1 0.74 9.8 0.0 2.5 2 0 0 2 2 2 0 Nicastrin small lobe zf-RING_2 PF13639.6 VDK75069.1 - 1.1e-07 32.0 7.6 2.4e-07 31.0 7.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 VDK75069.1 - 6.4e-07 29.1 8.6 1.3e-06 28.1 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK75069.1 - 6.9e-07 29.0 7.3 1.5e-06 28.0 7.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 VDK75069.1 - 1.6e-05 24.9 7.9 4.5e-05 23.5 7.9 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 VDK75069.1 - 3.2e-05 23.7 7.0 6.6e-05 22.7 7.0 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 VDK75069.1 - 8.8e-05 22.3 8.7 0.00019 21.2 8.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK75069.1 - 0.00011 22.1 3.2 0.00054 19.9 3.6 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 VDK75069.1 - 0.00059 19.7 7.7 0.0018 18.2 7.7 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 VDK75069.1 - 0.0081 15.9 5.9 0.011 15.6 4.6 2.0 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 VDK75069.1 - 0.012 15.7 4.2 0.029 14.4 4.2 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 VDK75069.1 - 0.23 11.2 5.0 0.52 10.0 5.0 1.5 1 0 0 1 1 1 0 P-11 zinc finger Ras PF00071.22 VDK75070.1 - 1.4e-15 57.3 0.0 3.8e-07 29.9 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 VDK75070.1 - 1.8e-12 47.5 0.2 1e-07 32.2 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK75070.1 - 0.0007 19.1 0.1 0.025 14.1 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF1132 PF06575.12 VDK75070.1 - 0.02 15.3 0.3 0.034 14.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1132) DLIC PF05783.11 VDK75070.1 - 0.029 13.2 0.2 0.049 12.4 0.2 1.6 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) Methyltransf_PK PF05891.12 VDK75071.1 - 1.3e-79 266.7 0.0 1.6e-79 266.5 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 VDK75071.1 - 1.2e-08 35.5 0.0 3.9e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK75071.1 - 1.8e-08 34.9 0.0 3.3e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK75071.1 - 4.7e-08 33.7 0.0 1.1e-07 32.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK75071.1 - 1.1e-06 28.6 0.0 1.8e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 VDK75071.1 - 0.00036 19.9 0.0 0.00064 19.1 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_31 PF13847.6 VDK75071.1 - 0.00077 19.3 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 VDK75071.1 - 0.0031 16.9 0.0 0.0044 16.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 VDK75071.1 - 0.032 13.8 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Zip PF02535.22 VDK75072.1 - 3.2e-35 121.9 17.8 2.3e-22 79.6 7.3 2.8 1 1 1 2 2 2 2 ZIP Zinc transporter EVC2_like PF12297.8 VDK75072.1 - 0.043 12.5 0.9 5.1 5.7 0.1 2.1 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein WD40 PF00400.32 VDK75073.1 - 5.2e-09 36.6 23.0 0.85 10.6 0.1 7.3 5 2 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK75073.1 - 3.4e-05 24.0 0.0 4.2 7.7 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 VDK75073.1 - 0.0016 17.8 0.0 0.03 13.6 0.0 2.3 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller CNDH2_C PF16858.5 VDK75074.1 - 1e-57 196.3 2.6 1e-57 196.3 2.6 1.7 1 1 1 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CNDH2_N PF06278.11 VDK75074.1 - 1.9e-25 89.3 0.2 5.4e-25 87.8 0.2 1.8 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CNDH2_M PF16869.5 VDK75074.1 - 5.1e-06 27.2 2.3 2.4e-05 25.1 2.3 2.3 1 1 0 1 1 1 1 PF16858 RINT1_TIP1 PF04437.13 VDK75075.1 - 3.5e-62 210.9 9.3 3.5e-62 210.9 9.3 2.6 2 1 0 2 2 2 2 RINT-1 / TIP-1 family DUF601 PF04642.12 VDK75075.1 - 0.03 13.8 0.1 0.053 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF601 RSS_P20 PF11757.8 VDK75075.1 - 0.32 11.5 6.1 0.19 12.2 2.4 2.5 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain GAT PF03127.14 VDK75075.1 - 6.1 7.2 9.0 1.2 9.4 1.0 3.9 4 0 0 4 4 4 0 GAT domain LETM1 PF07766.13 VDK75076.1 - 1.1e-47 162.6 4.9 1.1e-47 162.6 4.9 1.4 2 0 0 2 2 2 1 LETM1-like protein AalphaY_MDB PF04611.12 VDK75089.1 - 0.02 14.9 0.1 0.2 11.7 0.1 2.5 2 0 0 2 2 2 0 Mating type protein A alpha Y mating type dependent binding region AhpC-TSA PF00578.21 VDK75089.1 - 8.9 6.3 10.2 0.27 11.2 0.2 3.2 4 0 0 4 4 4 0 AhpC/TSA family Laps PF10169.9 VDK75090.1 - 1.3e-15 58.1 18.4 8.4e-09 36.1 7.5 2.1 1 1 1 2 2 2 2 Learning-associated protein DUF2423 PF10338.9 VDK75090.1 - 0.00036 20.7 9.4 0.00036 20.7 9.4 2.9 2 1 0 2 2 2 1 Protein of unknown function (DUF2423) NapB PF03892.14 VDK75091.1 - 0.61 10.1 4.5 1.8 8.6 2.5 2.1 2 0 0 2 2 2 0 Nitrate reductase cytochrome c-type subunit (NapB) Thyroglobulin_1 PF00086.18 VDK75094.1 - 3.1e-13 49.2 4.5 9.7e-13 47.6 2.7 2.1 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat SPARC_Ca_bdg PF10591.9 VDK75094.1 - 2e-11 44.2 1.6 2e-11 44.2 1.6 1.6 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_1 PF00036.32 VDK75094.1 - 2.1e-05 23.8 0.1 0.013 15.0 0.0 2.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 VDK75094.1 - 0.00025 20.7 0.0 0.046 13.7 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 VDK75094.1 - 0.0022 17.4 0.0 0.02 14.3 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 VDK75094.1 - 0.11 13.0 0.2 0.24 11.8 0.2 1.6 1 1 0 1 1 1 0 EF-hand domain pair BBS2_C PF14782.6 VDK75096.1 - 5.3e-115 384.6 5.8 5.5e-115 384.6 4.8 1.4 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid PF14783.6 VDK75096.1 - 1.9e-35 121.2 1.8 7.8e-33 112.7 0.0 3.5 4 0 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region BBS2_N PF14781.6 VDK75096.1 - 1e-12 47.9 1.4 1.6e-11 44.0 1.4 2.8 1 1 0 1 1 1 1 Ciliary BBSome complex subunit 2, N-terminal PQQ_2 PF13360.6 VDK75096.1 - 0.0014 18.3 0.0 0.0029 17.2 0.0 1.5 1 0 0 1 1 1 1 PQQ-like domain Itfg2 PF15907.5 VDK75096.1 - 0.0019 17.3 0.1 0.32 10.0 0.1 3.2 2 1 1 3 3 3 1 Integrin-alpha FG-GAP repeat-containing protein 2 FG-GAP PF01839.23 VDK75096.1 - 0.012 15.7 0.1 0.032 14.4 0.1 1.6 1 0 0 1 1 1 0 FG-GAP repeat VCBS PF13517.6 VDK75096.1 - 0.044 14.4 0.8 1.9 9.1 0.4 2.7 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Pkinase PF00069.25 VDK75097.1 - 5.3e-62 209.6 0.1 6.2e-62 209.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK75097.1 - 1.4e-36 126.1 0.0 1.7e-36 125.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK75097.1 - 5.3e-05 22.7 0.0 0.00015 21.2 0.0 1.6 1 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 VDK75097.1 - 0.013 14.4 1.5 0.042 12.8 1.5 1.8 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 VDK75097.1 - 0.049 12.4 0.0 0.092 11.5 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase Ras PF00071.22 VDK75099.1 - 6.9e-43 146.1 0.0 8.8e-43 145.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK75099.1 - 4.3e-19 68.9 0.0 7.2e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK75099.1 - 0.00078 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 VDK75099.1 - 0.024 15.0 0.0 0.19 12.1 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 VDK75099.1 - 0.038 14.1 0.1 0.13 12.4 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase TniB PF05621.11 VDK75099.1 - 0.086 12.2 0.0 0.45 9.9 0.0 2.1 3 0 0 3 3 3 0 Bacterial TniB protein AAA_7 PF12775.7 VDK75099.1 - 0.13 11.8 0.0 0.36 10.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region UPF0564 PF10595.9 VDK75100.1 - 3.8e-19 69.0 35.1 7.8e-19 67.9 34.8 1.7 1 1 0 1 1 1 1 Uncharacterised protein family UPF0564 Frag1 PF10277.9 VDK75101.1 - 8e-23 81.1 18.3 9.8e-23 80.8 18.3 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family DUF2070 PF09843.9 VDK75101.1 - 3.7 5.7 15.0 1.7 6.8 11.4 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) DUF373 PF04123.13 VDK75101.1 - 4.3 6.7 6.1 6.4 6.1 6.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) ATP-synt_E PF05680.12 VDK75103.1 - 1.4e-14 54.2 0.0 1.6e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 ATP synthase E chain DUF1011 PF06237.12 VDK75104.1 - 3.6e-28 97.8 6.5 3.6e-28 97.8 6.5 3.7 4 1 1 5 5 5 1 Protein of unknown function (DUF1011) DUF2615 PF11027.8 VDK75104.1 - 0.1 12.7 0.2 0.37 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) RNase_Zc3h12a PF11977.8 VDK75106.1 - 2.4e-22 79.4 0.1 5e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain DUF2897 PF11446.8 VDK75107.1 - 1.7 8.6 3.7 29 4.7 1.1 3.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) TH1 PF04858.13 VDK75121.1 - 4.1e-40 138.0 0.7 4.6e-40 137.8 0.7 1.0 1 0 0 1 1 1 1 TH1 protein YCF90 PF17088.5 VDK75121.1 - 0.073 12.4 0.2 0.11 11.8 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family Med12-LCEWAV PF12145.8 VDK75122.1 - 1e-57 196.1 2.8 9e-41 140.2 0.1 4.1 1 1 2 4 4 4 3 Eukaryotic Mediator 12 subunit domain Med12 PF09497.10 VDK75122.1 - 9.7e-12 45.0 0.1 4.1e-11 43.0 0.1 2.1 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Hydrolase_4 PF12146.8 VDK75123.1 - 2.2e-12 46.8 0.0 3.2e-07 29.9 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK75123.1 - 1.4e-10 41.3 0.0 0.00021 21.0 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 VDK75123.1 - 1.2e-06 28.2 0.0 1.7e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 VDK75123.1 - 5.8e-06 27.1 0.0 9.1e-05 23.2 0.0 2.0 1 1 0 2 2 2 1 Alpha/beta hydrolase family DUF818 PF05677.12 VDK75123.1 - 6.7e-06 25.3 0.0 9.8e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_2 PF02230.16 VDK75123.1 - 0.00036 20.4 0.0 0.18 11.6 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase LIP PF03583.14 VDK75123.1 - 0.0028 17.0 0.1 0.17 11.2 0.0 2.1 2 0 0 2 2 2 1 Secretory lipase DUF1057 PF06342.12 VDK75123.1 - 0.013 14.6 0.0 0.18 10.8 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF1057) FSH1 PF03959.13 VDK75123.1 - 0.033 13.9 0.0 0.045 13.4 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Pes-10 PF07149.11 VDK75125.1 - 4 6.4 7.5 5.5 5.9 7.5 1.1 1 0 0 1 1 1 0 Pes-10 Big_2 PF02368.18 VDK75130.1 - 1.1e-08 34.9 2.7 0.19 11.7 0.0 5.6 6 0 0 6 6 6 3 Bacterial Ig-like domain (group 2) CitMHS PF03600.16 VDK75132.1 - 1.2 8.2 10.0 1.4 8.0 10.0 1.1 1 0 0 1 1 1 0 Citrate transporter DUF2160 PF09928.9 VDK75132.1 - 7.4 7.0 17.2 3.2 8.1 5.2 2.9 2 1 1 3 3 3 0 Predicted small integral membrane protein (DUF2160) CSTF2_hinge PF14327.6 VDK75134.1 - 1.1e-29 102.6 2.4 1.1e-29 102.6 2.4 2.4 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 VDK75134.1 - 7.9e-23 80.1 0.0 1.4e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 VDK75134.1 - 3.3e-18 65.0 13.5 2.3e-17 62.3 10.7 3.0 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_8 PF11835.8 VDK75134.1 - 0.0084 16.3 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 1 RRM-like domain RRM_occluded PF16842.5 VDK75134.1 - 0.054 13.4 0.0 0.13 12.1 0.0 1.7 1 1 0 1 1 1 0 Occluded RNA-recognition motif Ig_3 PF13927.6 VDK75145.1 - 5.5e-15 55.7 0.0 1.5e-12 47.9 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 VDK75145.1 - 1e-14 54.3 0.0 7.8e-14 51.5 0.0 2.2 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_2 PF13895.6 VDK75145.1 - 3.7e-11 43.2 0.0 7.8e-08 32.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 VDK75145.1 - 3e-09 36.9 0.0 1.8e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 Immunoglobulin domain V-set PF07686.17 VDK75145.1 - 2.3e-05 24.5 0.0 0.0018 18.4 0.0 2.6 1 1 0 1 1 1 1 Immunoglobulin V-set domain LptF_LptG PF03739.14 VDK75145.1 - 0.0097 14.8 0.0 0.02 13.7 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG GT87 PF09594.10 VDK75145.1 - 0.017 14.8 0.2 0.026 14.2 0.2 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 87 GRDP-like PF07173.12 VDK75146.1 - 1.2e-45 155.7 13.0 3.8e-38 131.3 3.8 3.5 2 1 1 3 3 3 3 Glycine-rich domain-containing protein-like CHAT PF12770.7 VDK75146.1 - 0.0079 15.6 0.1 0.013 15.0 0.1 1.2 1 0 0 1 1 1 1 CHAT domain DUF4535 PF15054.6 VDK75147.1 - 3.2e-06 26.8 0.0 6.1e-06 25.9 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4535) ATPase_gene1 PF09527.10 VDK75147.1 - 0.092 12.9 0.0 0.26 11.5 0.0 1.6 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Nfu_N PF08712.11 VDK75149.1 - 5.4e-28 96.9 0.1 1.1e-27 95.9 0.0 1.6 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 VDK75149.1 - 3.5e-25 87.9 0.2 5.7e-25 87.2 0.2 1.3 1 0 0 1 1 1 1 NifU-like domain KH_1 PF00013.29 VDK75151.1 - 7.8e-06 25.6 0.0 1.6e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 KH domain Keratin_2_head PF16208.5 VDK75151.1 - 0.014 15.6 11.8 0.014 15.6 11.8 2.5 2 0 0 2 2 2 0 Keratin type II head CDP-OH_P_transf PF01066.21 VDK75152.1 - 4.4e-10 40.2 0.7 5.3e-10 39.9 0.7 1.1 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase Carb_anhydrase PF00194.21 VDK75157.1 - 4.3e-55 187.0 0.0 5.6e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Trns_repr_metal PF02583.17 VDK75157.1 - 0.09 13.2 0.1 0.45 10.9 0.0 2.2 2 0 0 2 2 2 0 Metal-sensitive transcriptional repressor Wtap PF17098.5 VDK75158.1 - 5.3e-28 97.9 14.5 5.3e-28 97.9 14.5 1.9 2 0 0 2 2 2 1 WTAP/Mum2p family DUF4201 PF13870.6 VDK75158.1 - 0.0084 15.9 10.1 0.0084 15.9 10.1 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF4201) Swi6_N PF18530.1 VDK75158.1 - 0.012 15.7 0.2 0.05 13.7 0.1 2.0 1 1 1 2 2 2 0 Swi6 N-terminal domain SlyX PF04102.12 VDK75158.1 - 0.016 15.8 1.7 0.016 15.8 1.7 4.0 3 3 0 3 3 3 0 SlyX RecQ_Zn_bind PF16124.5 VDK75158.1 - 0.025 15.3 1.6 0.025 15.3 1.6 2.2 2 0 0 2 2 2 0 RecQ zinc-binding SpecificRecomb PF10136.9 VDK75158.1 - 0.045 12.1 2.5 0.054 11.8 2.5 1.2 1 0 0 1 1 1 0 Site-specific recombinase FemAB_like PF04339.12 VDK75158.1 - 0.06 12.5 0.5 0.1 11.7 0.3 1.3 1 1 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition Nsp1_C PF05064.13 VDK75158.1 - 0.16 11.8 6.2 1.6 8.5 0.5 3.4 2 1 2 4 4 4 0 Nsp1-like C-terminal region EzrA PF06160.12 VDK75158.1 - 0.18 9.9 12.9 0.25 9.5 12.9 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA PhoU PF01895.19 VDK75158.1 - 0.25 11.8 3.6 0.92 10.0 0.6 2.9 2 1 1 3 3 3 0 PhoU domain HlyE PF06109.13 VDK75158.1 - 0.35 10.1 3.1 0.7 9.1 2.9 1.6 1 1 0 1 1 1 0 Haemolysin E (HlyE) ATG16 PF08614.11 VDK75158.1 - 0.41 10.8 25.1 0.52 10.5 11.9 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) NYD-SP28_assoc PF14775.6 VDK75158.1 - 0.44 10.7 4.7 9.9 6.4 0.4 2.9 2 0 0 2 2 2 0 Sperm tail C-terminal domain CP12 PF02672.15 VDK75158.1 - 1.1 10.0 5.4 1.1 10.1 0.8 2.9 1 1 1 2 2 2 0 CP12 domain DUF1664 PF07889.12 VDK75158.1 - 3.3 7.8 6.0 8.8 6.4 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PKcGMP_CC PF16808.5 VDK75158.1 - 3.4 7.6 11.3 14 5.7 1.9 3.7 2 1 2 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC_tran_CTD PF16326.5 VDK75158.1 - 4.4 7.6 14.4 0.76 10.1 1.9 3.0 3 0 0 3 3 3 0 ABC transporter C-terminal domain Csm2_III-A PF03750.13 VDK75158.1 - 4.6 8.1 8.4 21 6.0 0.4 2.4 2 0 0 2 2 2 0 Csm2 Type III-A Spc7 PF08317.11 VDK75158.1 - 7.3 5.4 23.5 3.6 6.4 14.9 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein Dus PF01207.17 VDK75159.1 - 1.1e-67 228.4 0.0 1.6e-67 227.8 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) NMO PF03060.15 VDK75159.1 - 0.0023 17.4 0.6 0.0038 16.7 0.0 1.5 2 0 0 2 2 2 1 Nitronate monooxygenase ThiG PF05690.14 VDK75159.1 - 0.015 14.6 0.1 0.026 13.8 0.1 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG PEP_mutase PF13714.6 VDK75159.1 - 0.098 12.1 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase HTH_25 PF13413.6 VDK75159.1 - 0.12 12.2 1.1 0.32 10.9 1.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Proteasome PF00227.26 VDK75160.1 - 1.2e-22 80.3 0.0 1.4e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit UPF0149 PF03695.13 VDK75160.1 - 0.015 15.6 0.0 0.022 15.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0149) Ribosomal_60s PF00428.19 VDK75173.1 - 4.8e-19 68.7 0.2 5.8e-19 68.5 0.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein GUCT PF08152.12 VDK75173.1 - 0.12 12.6 0.1 0.26 11.6 0.1 1.5 1 0 0 1 1 1 0 GUCT (NUC152) domain Ion_trans PF00520.31 VDK75175.1 - 2.4e-254 839.1 88.8 4.9e-70 235.6 9.7 4.1 4 0 0 4 4 4 4 Ion transport protein Ca_chan_IQ PF08763.11 VDK75175.1 - 4.9e-29 100.4 0.0 1.3e-28 99.1 0.0 1.8 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain GPHH PF16905.5 VDK75175.1 - 4.2e-28 96.9 0.1 1e-27 95.6 0.1 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated PKD_channel PF08016.12 VDK75175.1 - 9.8e-07 27.8 95.5 4.8e-05 22.2 9.9 10.4 7 4 3 10 10 10 7 Polycystin cation channel CAC1F_C PF16885.5 VDK75175.1 - 8.8e-06 25.6 4.9 0.03 14.0 0.0 3.5 2 1 0 3 3 3 2 Voltage-gated calcium channel subunit alpha, C-term EF-hand_11 PF08976.11 VDK75175.1 - 0.17 12.8 0.0 0.47 11.4 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain AIMP2_LysRS_bd PF16780.5 VDK75176.1 - 0.12 12.1 0.6 0.32 10.7 0.6 1.7 1 0 0 1 1 1 0 AIMP2 lysyl-tRNA synthetase binding domain L51_S25_CI-B8 PF05047.16 VDK75177.1 - 1.5e-06 28.0 0.0 2.7e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Abhydrolase_6 PF12697.7 VDK75178.1 - 9.7e-14 52.5 0.0 3.5e-11 44.1 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 VDK75178.1 - 1.9e-13 50.7 0.0 6.5e-08 32.5 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK75178.1 - 4.3e-05 22.9 0.0 0.00088 18.6 0.0 2.4 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 VDK75178.1 - 0.0094 16.0 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Ser_hydrolase PF06821.13 VDK75178.1 - 0.044 13.6 0.0 0.28 11.0 0.0 2.0 1 1 0 1 1 1 0 Serine hydrolase SSF PF00474.17 VDK75179.1 - 1.1e-34 120.0 15.6 1.8e-34 119.3 15.6 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family INPP5B_PH PF16776.5 VDK75179.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Gpi1 PF05024.15 VDK75179.1 - 0.44 10.6 10.7 0.028 14.5 3.3 2.2 2 0 0 2 2 2 0 N-acetylglucosaminyl transferase component (Gpi1) DnaJ PF00226.31 VDK75180.1 - 2.1e-25 88.6 1.7 3.3e-25 88.0 1.7 1.3 1 0 0 1 1 1 1 DnaJ domain Corona_S2 PF01601.16 VDK75180.1 - 8 4.8 16.7 11 4.4 16.7 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Nitroreductase PF00881.24 VDK75182.1 - 2.9e-21 76.3 0.0 5.1e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 VDK75182.1 - 2.9e-07 30.3 0.0 0.0026 17.3 0.0 3.0 2 1 1 3 3 3 3 Putative TM nitroreductase Vezatin PF12632.7 VDK75182.1 - 0.12 11.7 0.1 0.21 10.9 0.1 1.4 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes WD40 PF00400.32 VDK75189.1 - 1.6e-14 54.0 13.1 0.00013 22.7 1.0 7.1 6 1 0 6 6 6 4 WD domain, G-beta repeat Phage_Mu_Gp45 PF06890.12 VDK75189.1 - 0.021 14.6 0.0 0.073 12.8 0.0 1.9 2 0 0 2 2 2 0 Bacteriophage Mu Gp45 protein bZIP_1 PF00170.21 VDK75190.1 - 1.9e-05 24.7 13.4 1.9e-05 24.7 13.4 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 VDK75190.1 - 0.00032 21.1 7.3 0.00032 21.1 7.3 1.7 2 0 0 2 2 2 1 bZIP Maf transcription factor bZIP_2 PF07716.15 VDK75190.1 - 0.0029 17.7 16.9 0.0029 17.7 16.9 2.1 2 1 1 3 3 3 2 Basic region leucine zipper GIT_CC PF16559.5 VDK75190.1 - 0.017 15.0 2.5 0.04 13.8 2.5 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2524 PF10732.9 VDK75190.1 - 0.32 11.3 7.6 0.64 10.4 7.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2524) DivIC PF04977.15 VDK75190.1 - 3.3 7.6 8.2 2.5 8.0 5.3 2.2 1 1 1 2 2 2 0 Septum formation initiator Fib_alpha PF08702.10 VDK75190.1 - 5.6 7.2 10.9 0.72 10.0 6.1 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ThiF PF00899.21 VDK75192.1 - 4.4e-41 140.9 0.4 3.3e-23 82.3 0.1 2.1 1 1 1 2 2 2 2 ThiF family Rhodanese PF00581.20 VDK75192.1 - 1.8e-09 38.1 0.0 4.7e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain CMV_1a_C PF12503.8 VDK75192.1 - 0.011 15.7 0.0 0.031 14.3 0.0 1.7 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein C terminal NtA PF03146.15 VDK75192.1 - 0.13 12.2 0.0 0.92 9.4 0.0 2.2 2 0 0 2 2 2 0 Agrin NtA domain fn3 PF00041.21 VDK75194.1 - 1.3e-34 118.4 0.2 4.4e-13 49.4 0.0 5.3 4 1 1 5 5 5 4 Fibronectin type III domain Oxysterol_BP PF01237.18 VDK75212.1 - 6.7e-123 410.2 0.3 1.1e-122 409.5 0.3 1.3 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 VDK75212.1 - 1.6e-12 47.5 0.1 3.3e-12 46.5 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 VDK75212.1 - 7.8e-11 42.4 0.7 2e-10 41.1 0.7 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 VDK75212.1 - 0.00045 20.6 2.4 0.008 16.6 2.4 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain Secretin_N PF03958.17 VDK75212.1 - 0.069 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain COMM_domain PF07258.14 VDK75213.1 - 0.00078 19.5 1.5 0.0086 16.2 0.3 2.7 2 1 0 2 2 2 1 COMM domain UBA_e1_thiolCys PF10585.9 VDK75213.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site JmjC PF02373.22 VDK75214.1 - 3.7e-20 72.5 4.0 3.9e-19 69.2 4.0 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 VDK75214.1 - 1.3e-10 41.4 6.1 5.7e-10 39.3 6.1 1.9 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 VDK75214.1 - 0.007 15.9 0.0 0.0099 15.4 0.0 1.2 1 0 0 1 1 1 1 Cupin superfamily protein Pox_A_type_inc PF04508.12 VDK75214.1 - 1.3 9.0 6.5 0.28 11.1 0.9 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Methyltransf_16 PF10294.9 VDK75217.1 - 7.7e-28 97.4 0.0 1e-27 97.0 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 VDK75217.1 - 0.00016 21.3 0.0 0.00023 20.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 VDK75217.1 - 0.0065 15.9 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) GidB PF02527.15 VDK75217.1 - 0.11 11.8 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G PHD PF00628.29 VDK75218.1 - 3.5e-18 65.2 29.4 1.1e-10 41.2 8.8 3.0 3 0 0 3 3 3 2 PHD-finger PHF12_MRG_bd PF16737.5 VDK75218.1 - 0.00018 21.1 0.0 0.00043 19.9 0.0 1.6 1 0 0 1 1 1 1 PHD finger protein 12 MRG binding domain PHD_2 PF13831.6 VDK75218.1 - 0.00031 20.2 19.4 0.003 17.1 1.1 3.3 3 0 0 3 3 3 2 PHD-finger C1_1 PF00130.22 VDK75218.1 - 0.018 14.9 2.2 0.018 14.9 2.2 3.3 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 VDK75218.1 - 0.045 13.9 1.1 0.045 13.9 1.1 3.0 2 0 0 2 2 2 0 KIAA1045 RING finger zf-PHD-like PF15446.6 VDK75218.1 - 1.3 8.6 16.8 0.31 10.6 4.2 3.1 2 1 0 2 2 2 0 PHD/FYVE-zinc-finger like domain GMP_PDE_delta PF05351.11 VDK75219.1 - 3.9e-73 244.7 1.9 4.8e-73 244.4 1.9 1.1 1 0 0 1 1 1 1 GMP-PDE, delta subunit SIR2 PF02146.17 VDK75220.1 - 1.6e-25 90.1 0.0 1.3e-16 61.0 0.0 2.2 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 VDK75220.1 - 0.0017 18.1 0.0 0.0082 15.9 0.0 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain AAA_17 PF13207.6 VDK75220.1 - 0.096 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DDRGK PF09756.9 VDK75221.1 - 0.025 14.2 0.5 0.066 12.8 0.5 1.6 1 0 0 1 1 1 0 DDRGK domain HTH_33 PF13592.6 VDK75221.1 - 0.06 13.0 0.0 1 9.0 0.0 2.6 3 0 0 3 3 3 0 Winged helix-turn helix 2OG-FeII_Oxy_2 PF13532.6 VDK75222.1 - 0.00029 21.1 0.2 0.0016 18.6 0.0 2.1 2 1 1 3 3 3 1 2OG-Fe(II) oxygenase superfamily Pyrophosphatase PF00719.19 VDK75224.1 - 1.1e-54 184.6 0.3 1.9e-54 183.8 0.3 1.5 1 0 0 1 1 1 1 Inorganic pyrophosphatase Cullin PF00888.22 VDK75224.1 - 1.2e-20 73.8 0.2 2.5e-20 72.7 0.2 1.4 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 VDK75224.1 - 1.1e-10 41.8 0.0 3.1e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 CCM2_C PF16545.5 VDK75224.1 - 0.044 14.3 0.0 0.15 12.6 0.0 1.9 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology Nse4_C PF08743.10 VDK75226.1 - 1.9e-25 88.9 0.1 6.2e-23 80.9 0.0 2.5 2 1 0 2 2 2 2 Nse4 C-terminal BORCS6 PF10157.9 VDK75226.1 - 0.017 15.3 0.8 0.045 14.0 0.0 2.0 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 6 tRNA-Thr_ED PF08915.11 VDK75226.1 - 0.42 10.7 2.1 8.7 6.4 0.1 2.5 2 1 1 3 3 3 0 Archaea-specific editing domain of threonyl-tRNA synthetase bVLRF1 PF18826.1 VDK75229.1 - 2.5e-46 157.3 0.0 5.6e-46 156.1 0.0 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 VDK75229.1 - 0.001 19.4 0.0 0.003 17.8 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) BRCA-2_helical PF09169.10 VDK75229.1 - 0.032 13.9 2.2 0.11 12.1 2.4 1.8 2 0 0 2 2 2 0 BRCA2, helical Perilipin PF03036.16 VDK75229.1 - 0.22 10.5 5.7 0.35 9.9 5.7 1.2 1 0 0 1 1 1 0 Perilipin family NUDIX PF00293.28 VDK75230.1 - 2.5e-14 53.5 0.0 4.8e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain SPC22 PF04573.12 VDK75231.1 - 1.4e-48 164.6 1.7 1.6e-48 164.4 1.7 1.0 1 0 0 1 1 1 1 Signal peptidase subunit CBM_3 PF00942.18 VDK75231.1 - 0.025 15.0 0.2 0.15 12.5 0.1 2.0 2 0 0 2 2 2 0 Cellulose binding domain UCH PF00443.29 VDK75232.1 - 4.2e-58 196.9 4.0 5.5e-58 196.5 4.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK75232.1 - 1.5e-28 100.3 11.0 1.9e-28 100.0 11.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 VDK75232.1 - 0.00086 18.9 14.5 0.035 13.6 14.5 2.9 1 1 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase IFT81_CH PF18383.1 VDK75232.1 - 0.07 13.4 0.2 0.86 9.9 0.1 2.4 1 1 1 2 2 2 0 Intraflagellar transport 81 calponin homology domain DUF5532 PF17673.1 VDK75232.1 - 0.13 12.4 2.2 0.25 11.4 0.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5532) DSPc PF00782.20 VDK75234.1 - 1.9e-33 115.1 0.0 5e-33 113.7 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEK_C PF08766.11 VDK75234.1 - 1.7e-12 47.1 1.5 3.9e-12 45.9 1.5 1.7 1 0 0 1 1 1 1 DEK C terminal domain Y_phosphatase PF00102.27 VDK75234.1 - 0.0067 16.0 0.4 0.021 14.4 0.4 1.8 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Vel1p PF10339.9 VDK75234.1 - 0.07 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Yeast-specific zinc responsive KCNQ2_u3 PF16642.5 VDK75234.1 - 0.12 13.4 0.8 1.9 9.5 0.2 2.6 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 MazG PF03819.17 VDK75248.1 - 0.017 15.3 0.3 0.12 12.6 0.2 2.1 2 0 0 2 2 2 0 MazG nucleotide pyrophosphohydrolase domain BTB PF00651.31 VDK75248.1 - 0.037 14.3 1.0 0.1 12.8 1.0 1.8 1 0 0 1 1 1 0 BTB/POZ domain PPI_Ypi1 PF07491.11 VDK75249.1 - 1.3e-19 69.8 4.7 1.7e-19 69.4 4.7 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor Ribosomal_L22 PF00237.19 VDK75250.1 - 1.5e-31 108.7 0.1 1.5e-31 108.7 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e NAC PF01849.18 VDK75251.1 - 2.5e-23 81.8 0.0 7.1e-23 80.3 0.0 1.9 1 0 0 1 1 1 1 NAC domain Folliculin PF11704.8 VDK75251.1 - 0.032 14.1 0.2 0.067 13.1 0.2 1.5 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Zip PF02535.22 VDK75251.1 - 0.27 10.4 0.6 0.27 10.4 0.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 VDK75251.1 - 0.76 8.5 3.3 1.3 7.8 3.3 1.3 1 0 0 1 1 1 0 Presenilin TRAM_LAG1_CLN8 PF03798.16 VDK75252.1 - 1.4e-41 142.4 27.6 1.4e-41 142.4 27.6 1.7 2 0 0 2 2 2 1 TLC domain Ribosomal_S4e PF00900.20 VDK75256.1 - 5.3e-33 112.7 0.9 2.6e-32 110.6 0.5 2.2 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 VDK75256.1 - 1.4e-23 82.3 0.1 2.9e-23 81.3 0.1 1.6 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 VDK75256.1 - 6.4e-21 74.2 6.5 1.3e-20 73.2 6.5 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 VDK75256.1 - 2.7e-08 33.4 0.1 1.4e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 S4 domain KOW PF00467.29 VDK75256.1 - 8.5e-06 25.5 0.9 8.5e-06 25.5 0.9 2.1 2 0 0 2 2 2 1 KOW motif zf-C2H2 PF00096.26 VDK75257.1 - 8.5e-18 63.7 34.2 2.7e-06 27.5 0.8 5.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK75257.1 - 6.5e-16 58.0 29.7 1.8e-07 31.2 0.3 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK75257.1 - 1.1e-07 32.1 30.3 0.0017 19.0 0.7 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger zf_ZIC PF18366.1 VDK75257.1 - 9.1e-07 28.9 11.1 1.1e-06 28.6 0.1 3.7 3 1 1 4 4 4 2 Zic proteins zinc finger domain zf-met PF12874.7 VDK75257.1 - 0.00014 22.2 10.2 1.8 9.0 0.1 4.8 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK75257.1 - 0.0044 17.3 13.5 0.056 13.8 0.1 4.6 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 VDK75257.1 - 0.082 13.5 13.2 10 6.9 0.8 4.4 3 2 2 5 5 5 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 VDK75257.1 - 0.99 9.5 6.7 0.33 11.0 0.2 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger Zap1_zf2 PF18217.1 VDK75257.1 - 2.2 8.3 5.4 46 4.1 5.4 2.9 1 1 0 1 1 1 0 Zap1 zinc finger 2 Zf_RING PF16744.5 VDK75257.1 - 5.2 7.3 8.6 1.2 9.3 0.1 3.3 2 1 0 3 3 3 0 KIAA1045 RING finger COesterase PF00135.28 VDK75259.1 - 9.5e-129 430.6 0.0 1.5e-128 429.9 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Ly-6_related PF06579.12 VDK75262.1 - 0.0026 18.0 5.3 0.0058 16.9 5.4 1.6 1 1 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein Laminin_G_2 PF02210.24 VDK75269.1 - 1.8e-23 83.5 0.0 2.2e-23 83.2 0.0 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 VDK75269.1 - 4e-21 75.6 0.1 4.9e-21 75.3 0.1 1.1 1 0 0 1 1 1 1 Laminin G domain Laminin_G_3 PF13385.6 VDK75269.1 - 8.2e-05 22.8 0.0 0.0001 22.5 0.0 1.1 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Arrestin_N PF00339.29 VDK75271.1 - 1.2e-17 64.3 0.0 7e-17 61.8 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 VDK75271.1 - 9.8e-17 61.7 0.1 3.9e-11 43.5 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Nro1 PF12753.7 VDK75271.1 - 0.029 13.3 0.0 0.043 12.8 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Arrestin_N PF00339.29 VDK75273.1 - 1.2e-17 64.3 0.0 7e-17 61.8 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 VDK75273.1 - 9.8e-17 61.7 0.1 3.9e-11 43.5 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Nro1 PF12753.7 VDK75273.1 - 0.029 13.3 0.0 0.043 12.8 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Laminin_EGF PF00053.24 VDK75274.1 - 2.1e-142 463.2 415.7 2.1e-10 40.5 11.3 22.4 21 1 1 22 22 22 21 Laminin EGF domain Laminin_G_2 PF02210.24 VDK75274.1 - 6.1e-105 346.8 6.2 2e-25 89.8 0.2 5.8 6 0 0 6 6 5 5 Laminin G domain Laminin_G_1 PF00054.23 VDK75274.1 - 7.1e-93 307.7 0.1 9.8e-23 80.8 0.0 5.7 5 1 0 5 5 5 5 Laminin G domain Laminin_N PF00055.17 VDK75274.1 - 1.8e-51 175.0 0.8 3.6e-39 134.7 0.1 4.6 3 1 1 4 4 2 2 Laminin N-terminal (Domain VI) Laminin_B PF00052.18 VDK75274.1 - 4e-20 72.1 0.0 7.9e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Laminin B (Domain IV) Laminin_G_3 PF13385.6 VDK75274.1 - 1.8e-18 67.1 1.0 0.0017 18.5 0.0 5.6 5 1 0 5 5 5 4 Concanavalin A-like lectin/glucanases superfamily Laminin_II PF06009.12 VDK75274.1 - 1.8e-14 54.0 14.6 2.5e-12 47.0 0.3 4.9 3 1 2 5 5 5 3 Laminin Domain II Aida_N PF08910.10 VDK75274.1 - 0.49 10.8 2.3 4.9 7.6 0.8 2.7 2 0 0 2 2 2 0 Aida N-terminus Med30 PF11315.8 VDK75274.1 - 2.5 8.3 10.3 0.95 9.7 1.1 2.8 3 0 0 3 3 2 0 Mediator complex subunit 30 F_actin_bind PF08919.10 VDK75274.1 - 4.3 7.5 8.2 0.82 9.8 0.1 3.4 2 1 1 3 3 3 0 F-actin binding Baculo_PEP_C PF04513.12 VDK75274.1 - 8.3 6.4 8.4 0.39 10.8 1.6 2.3 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus SecY PF00344.20 VDK75276.1 - 7.1e-76 255.4 11.7 9.4e-76 255.0 11.7 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 VDK75276.1 - 6.4e-18 64.3 1.6 9.1e-18 63.8 0.1 2.1 2 0 0 2 2 2 1 Plug domain of Sec61p MBOAT PF03062.19 VDK75277.1 - 9.4e-12 44.9 23.3 9.4e-12 44.9 23.3 3.6 3 1 1 4 4 4 1 MBOAT, membrane-bound O-acyltransferase family T_cell_tran_alt PF15128.6 VDK75277.1 - 0.49 10.2 3.2 15 5.5 0.4 3.1 2 0 0 2 2 2 0 T-cell leukemia translocation-altered Vps16_N PF04841.13 VDK75281.1 - 7.2e-54 183.1 0.1 1e-53 182.6 0.1 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 VDK75281.1 - 3.5e-29 101.9 9.9 3.5e-29 101.9 9.9 1.5 2 0 0 2 2 2 1 Vps16, C-terminal region Clathrin PF00637.20 VDK75281.1 - 0.004 17.0 0.5 0.019 14.8 0.5 2.2 1 0 0 1 1 1 1 Region in Clathrin and VPS KfrA_N PF11740.8 VDK75281.1 - 0.11 13.1 0.0 0.35 11.5 0.0 1.9 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term ArfGap PF01412.18 VDK75282.1 - 8.2e-26 90.4 1.2 9.1e-25 87.0 1.0 2.4 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf GIT_CC PF16559.5 VDK75282.1 - 1.1e-21 76.5 0.6 1.1e-21 76.5 0.6 2.0 2 0 0 2 2 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor GIT_SHD PF08518.11 VDK75282.1 - 1.4e-17 62.9 6.8 3.3e-10 39.4 1.5 3.5 3 0 0 3 3 3 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 VDK75282.1 - 3e-06 27.3 0.6 3e-06 27.3 0.6 2.6 2 1 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term Ank_4 PF13637.6 VDK75282.1 - 0.001 19.6 0.1 0.0044 17.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Phage_lysis PF03245.13 VDK75282.1 - 0.048 13.8 0.4 0.14 12.3 0.4 1.8 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein TolA_bind_tri PF16331.5 VDK75282.1 - 0.084 13.0 4.5 0.082 13.0 1.1 2.7 2 0 0 2 2 2 0 TolA binding protein trimerisation Fungal_TACC PF12709.7 VDK75282.1 - 0.11 13.0 0.4 8.6 6.9 0.0 2.9 2 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Ank PF00023.30 VDK75282.1 - 0.32 11.5 1.0 3.1 8.4 0.1 3.1 3 0 0 3 3 3 0 Ankyrin repeat Baculo_PEP_C PF04513.12 VDK75282.1 - 0.7 9.9 4.6 2.7 8.0 1.3 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 VDK75282.1 - 0.85 9.9 3.3 8.9 6.7 0.5 3.5 4 0 0 4 4 3 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 VDK75282.1 - 1.3 9.0 4.4 1.1 9.3 1.9 2.2 2 0 0 2 2 2 0 Laminin Domain II ATG16 PF08614.11 VDK75282.1 - 3.5 7.8 8.3 0.4 10.9 1.8 2.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) RNase_Zc3h12a PF11977.8 VDK75283.1 - 1e-26 93.6 0.0 1.8e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain LRR_8 PF13855.6 VDK75284.1 - 3.4e-14 52.4 1.1 2e-09 37.0 0.5 2.4 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 VDK75284.1 - 2.5e-13 50.0 5.1 1e-07 32.1 0.3 3.7 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK75284.1 - 0.0015 18.8 3.4 4.2 8.3 0.1 4.5 4 1 0 4 4 4 1 Leucine Rich Repeat LRR_9 PF14580.6 VDK75284.1 - 0.007 15.9 0.7 0.013 15.0 0.2 1.6 1 1 1 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 VDK75284.1 - 0.036 14.1 7.1 0.082 13.0 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich repeat KOW PF00467.29 VDK75290.1 - 6.4e-08 32.3 0.0 1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 KOW motif MMR_HSR1 PF01926.23 VDK75291.1 - 3.3e-16 59.4 0.0 8.5e-15 54.8 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK75291.1 - 6.7e-09 35.4 0.0 8.5e-05 22.1 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 VDK75291.1 - 1e-05 25.5 0.6 0.0062 16.5 0.1 2.9 2 0 0 2 2 2 2 RsgA GTPase AIG1 PF04548.16 VDK75291.1 - 0.036 13.4 2.1 0.078 12.3 0.0 2.5 3 0 0 3 3 3 0 AIG1 family RNB PF00773.19 VDK75291.1 - 0.66 9.2 6.4 0.16 11.3 0.3 2.7 3 0 0 3 3 3 0 RNB domain dsrm PF00035.26 VDK75292.1 - 1.5e-11 44.8 1.7 0.0038 17.9 0.0 4.2 4 0 0 4 4 4 3 Double-stranded RNA binding motif WW PF00397.26 VDK75292.1 - 0.0041 17.2 0.0 0.0081 16.2 0.0 1.5 1 0 0 1 1 1 1 WW domain MH2 PF03166.14 VDK75294.1 - 1e-13 52.0 0.0 1.8e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 VDK75294.1 - 7.8e-10 38.9 1.3 5.5e-09 36.2 0.1 2.5 1 1 1 2 2 2 1 MH1 domain HTH_29 PF13551.6 VDK75294.1 - 0.1 12.6 0.6 0.38 10.8 0.2 2.2 2 0 0 2 2 2 0 Winged helix-turn helix UPF0220 PF05255.11 VDK75298.1 - 1.6e-44 151.4 7.4 1.8e-44 151.2 7.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF3040 PF11239.8 VDK75298.1 - 0.031 14.5 1.4 1.1 9.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) ABC_membrane PF00664.23 VDK75299.1 - 1.3e-34 120.1 11.4 1.7e-34 119.7 11.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 VDK75299.1 - 2.4e-33 115.5 0.0 4.7e-33 114.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 VDK75299.1 - 3.7e-06 26.6 0.8 0.0004 19.9 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 VDK75299.1 - 0.0013 18.8 0.0 0.27 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 VDK75299.1 - 0.0016 18.1 0.0 0.0045 16.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 VDK75299.1 - 0.0035 17.1 0.1 0.0064 16.2 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 VDK75299.1 - 0.0082 15.9 0.0 0.018 14.7 0.0 1.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 VDK75299.1 - 0.013 15.6 0.1 0.026 14.6 0.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_21 PF13304.6 VDK75299.1 - 0.015 15.1 0.1 0.13 12.0 0.0 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 VDK75299.1 - 0.017 14.3 0.4 0.052 12.7 0.0 2.0 2 1 0 2 2 2 0 G-protein alpha subunit AAA_16 PF13191.6 VDK75299.1 - 0.03 14.7 0.0 0.071 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 VDK75299.1 - 0.097 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 VDK75299.1 - 0.11 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PRK PF00485.18 VDK75299.1 - 0.12 12.1 0.0 0.91 9.2 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_23 PF13476.6 VDK75299.1 - 0.17 12.3 0.0 0.33 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK75299.1 - 0.18 12.1 0.1 0.72 10.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain Defensin_like PF10868.8 VDK75300.1 - 0.049 14.4 0.1 0.12 13.1 0.1 1.6 1 0 0 1 1 1 0 Cysteine-rich antifungal protein 2, defensin-like HTH_Tnp_Tc3_2 PF01498.18 VDK75300.1 - 0.097 12.9 0.8 2 8.7 0.1 2.6 2 0 0 2 2 2 0 Transposase Arg_repressor PF01316.21 VDK75300.1 - 0.35 10.6 2.3 3.1 7.6 0.1 3.2 4 0 0 4 4 4 0 Arginine repressor, DNA binding domain zf-CCHC_2 PF13696.6 VDK75301.1 - 4.7e-09 35.9 5.0 1.1e-08 34.7 5.0 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 VDK75301.1 - 2.2e-07 30.6 6.8 6.1e-07 29.2 6.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK75301.1 - 0.00075 19.5 7.8 0.0019 18.2 7.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger U-box PF04564.15 VDK75301.1 - 0.00083 19.5 1.1 0.0037 17.4 0.0 2.8 3 0 0 3 3 3 1 U-box domain zf-RING_5 PF14634.6 VDK75301.1 - 0.0017 18.3 8.8 0.0017 18.3 8.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 VDK75301.1 - 0.0018 18.6 8.1 0.0042 17.4 8.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 VDK75301.1 - 0.0036 17.1 5.2 0.0036 17.1 5.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.23 VDK75301.1 - 0.045 13.8 2.1 0.11 12.6 2.1 1.7 1 0 0 1 1 1 0 Zinc knuckle zf-C3HC4_4 PF15227.6 VDK75301.1 - 0.083 13.1 9.4 0.18 12.0 9.4 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 VDK75301.1 - 0.44 10.4 5.4 0.97 9.3 5.4 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.6 VDK75301.1 - 0.54 10.2 14.4 0.049 13.5 7.8 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 VDK75301.1 - 0.54 10.2 3.5 1.1 9.2 3.5 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein GCV_H PF01597.19 VDK75315.1 - 0.053 13.4 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein GPCR_chapero_1 PF11904.8 VDK75316.1 - 2.7e-55 188.0 7.1 2.2e-53 181.7 7.1 2.2 1 1 0 1 1 1 1 GPCR-chaperone Ank_2 PF12796.7 VDK75316.1 - 4.3e-10 40.0 0.2 1.1e-09 38.7 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK75316.1 - 2.2e-07 31.3 2.6 3.6e-05 24.2 0.5 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 VDK75316.1 - 9.6e-07 29.0 1.0 0.058 13.9 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 VDK75316.1 - 8.9e-06 25.7 0.2 4.2 8.2 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 VDK75316.1 - 0.00067 19.9 1.5 0.0013 19.0 0.5 2.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) SdiA-regulated PF06977.11 VDK75316.1 - 0.06 12.6 0.1 0.43 9.8 0.0 2.1 1 1 1 2 2 2 0 SdiA-regulated Cytochrom_C_asm PF01578.20 VDK75317.1 - 0.012 15.4 0.1 0.013 15.2 0.1 1.1 1 0 0 1 1 1 0 Cytochrome C assembly protein MAP17 PF15807.5 VDK75317.1 - 0.097 12.9 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 MFS_1 PF07690.16 VDK75318.1 - 4e-22 78.6 39.4 4e-22 78.6 39.4 2.4 2 1 1 3 3 3 2 Major Facilitator Superfamily OSTMP1 PF09777.9 VDK75318.1 - 0.042 13.2 0.4 0.1 11.9 0.4 1.6 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor RseC_MucC PF04246.12 VDK75318.1 - 0.68 9.9 0.0 0.68 9.9 0.0 3.8 3 1 2 5 5 5 0 Positive regulator of sigma(E), RseC/MucC Pkinase PF00069.25 VDK75319.1 - 6.6e-68 228.9 0.0 7.6e-68 228.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK75319.1 - 1.2e-30 106.6 0.0 1.7e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK75319.1 - 0.00065 19.1 0.0 0.0038 16.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.25 VDK75320.1 - 2.7e-75 253.1 0.0 3.1e-75 253.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK75320.1 - 2.6e-33 115.4 0.0 6.6e-33 114.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK75320.1 - 2.5e-06 26.7 0.2 7.9e-06 25.0 0.0 1.8 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 VDK75320.1 - 0.00031 20.2 0.3 0.00073 19.0 0.3 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK75320.1 - 0.00042 19.7 0.0 0.00071 19.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 VDK75320.1 - 0.0016 18.1 0.0 0.0024 17.5 0.0 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 VDK75320.1 - 0.0039 17.1 0.0 0.0075 16.2 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 VDK75320.1 - 0.038 13.0 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 zf-CDGSH PF09360.10 VDK75321.1 - 0.0025 18.0 0.1 0.005 17.0 0.1 1.4 1 0 0 1 1 1 1 Iron-binding zinc finger CDGSH type HSP70 PF00012.20 VDK75324.1 - 2.6e-104 349.6 0.5 3.1e-104 349.3 0.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 VDK75324.1 - 3.2e-16 59.0 1.0 3.2e-16 59.0 1.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein Actin PF00022.19 VDK75324.1 - 0.00093 17.9 0.1 0.16 10.6 0.1 2.3 1 1 1 2 2 2 2 Actin Raco_middle PF17651.1 VDK75324.1 - 0.0026 17.5 0.6 0.051 13.3 0.0 2.8 3 0 0 3 3 3 1 RACo middle region StbA PF06406.11 VDK75324.1 - 0.037 13.2 0.0 0.09 12.0 0.0 1.6 1 0 0 1 1 1 0 StbA protein Humanin PF15040.6 VDK75324.1 - 0.051 13.0 0.3 0.37 10.3 0.1 2.3 2 0 0 2 2 2 0 Humanin family Metallophos PF00149.28 VDK75325.1 - 6.1e-26 92.2 0.0 1.3e-25 91.1 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase CybS PF05328.12 VDK75328.1 - 1.6e-16 60.2 2.7 1.9e-11 43.8 0.3 2.1 1 1 1 2 2 2 2 CybS, succinate dehydrogenase cytochrome B small subunit FAD_binding_1 PF00667.20 VDK75330.1 - 7e-27 94.4 0.0 1.4e-26 93.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 VDK75330.1 - 0.0097 16.5 0.0 0.019 15.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain BTB PF00651.31 VDK75331.1 - 0.027 14.7 0.4 0.1 12.8 0.1 2.0 2 0 0 2 2 2 0 BTB/POZ domain Fructosamin_kin PF03881.14 VDK75332.1 - 5.7e-74 248.9 0.0 7.5e-74 248.5 0.0 1.2 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 VDK75332.1 - 0.00014 21.8 0.0 0.0003 20.8 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 VDK75332.1 - 0.00039 20.1 0.0 0.0024 17.5 0.0 2.0 2 0 0 2 2 2 1 RIO1 family PXA PF02194.15 VDK75333.1 - 3.5e-47 160.8 1.9 5.8e-47 160.0 1.0 1.9 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 VDK75333.1 - 7.6e-27 94.1 1.0 2.4e-26 92.5 0.4 2.1 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 VDK75333.1 - 8.2e-15 54.8 0.0 1.9e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 PX domain RGS PF00615.19 VDK75333.1 - 8.2e-12 45.4 0.3 2.9e-11 43.7 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain CATSPERB PF15149.6 VDK75333.1 - 0.083 11.4 0.1 0.13 10.8 0.1 1.2 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit beta protein family Kelch_5 PF13854.6 VDK75335.1 - 9.5e-20 70.2 6.3 9.9e-07 28.6 0.2 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 VDK75335.1 - 4.3e-18 65.1 13.0 8.9e-08 32.2 0.2 5.6 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 VDK75335.1 - 5.4e-14 51.9 8.0 0.00054 20.1 0.0 6.8 6 1 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 VDK75335.1 - 1.6e-12 47.2 5.7 5.5e-08 32.7 0.0 5.6 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 VDK75335.1 - 5.1e-12 45.3 1.8 0.018 15.0 0.0 6.3 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 VDK75335.1 - 8.8e-12 44.4 1.5 0.0057 16.2 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Fibrinogen_C PF00147.18 VDK75336.1 - 3.7e-17 62.9 0.1 7.5e-17 61.9 0.1 1.6 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Ldl_recept_a PF00057.18 VDK75336.1 - 0.00031 20.9 5.3 0.00031 20.9 5.3 4.1 3 0 0 3 3 3 1 Low-density lipoprotein receptor domain class A zf-TRAF PF02176.18 VDK75336.1 - 9.1 7.1 15.2 0.37 11.5 7.5 2.8 2 1 0 2 2 2 0 TRAF-type zinc finger Peroxin-13_N PF04088.13 VDK75338.1 - 1.9e-35 122.3 0.6 2.5e-35 121.9 0.6 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 VDK75338.1 - 2.2e-05 24.0 0.0 4.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 VDK75338.1 - 5.7e-05 22.9 0.0 9.8e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK75338.1 - 0.026 14.1 0.0 0.074 12.7 0.0 1.8 1 1 0 1 1 1 0 SH3 domain Homeodomain PF00046.29 VDK75339.1 - 2.7e-20 72.0 2.7 3.9e-20 71.5 2.7 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK75339.1 - 0.022 14.7 1.0 0.1 12.5 0.2 2.4 2 0 0 2 2 2 0 Homeobox KN domain Med26_C PF15693.5 VDK75339.1 - 0.033 14.3 0.5 0.038 14.1 0.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal GST_C_6 PF17171.4 VDK75340.1 - 5.9e-15 54.8 0.0 9.4e-15 54.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 VDK75340.1 - 3.7e-07 30.1 0.0 7.5e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 VDK75340.1 - 0.00028 21.0 0.0 0.00093 19.4 0.0 1.7 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 VDK75340.1 - 0.0057 16.8 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain pEK499_p136 PF18736.1 VDK75358.1 - 0.028 14.1 0.0 0.11 12.1 0.0 1.9 1 0 0 1 1 1 0 HEPN pEK499 p136 Dna2 PF08696.11 VDK75358.1 - 0.065 13.0 4.8 0.11 12.2 1.7 2.2 2 0 0 2 2 2 0 DNA replication factor Dna2 HMG_box PF00505.19 VDK75358.1 - 0.22 12.0 11.7 4.8 7.7 0.9 4.0 3 1 0 3 3 3 0 HMG (high mobility group) box Muted PF14942.6 VDK75358.1 - 9.6 6.5 10.7 1.6 9.1 5.6 2.1 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein DSL PF01414.19 VDK75360.1 - 1.2e-15 57.5 5.3 1.2e-15 57.5 5.3 5.8 3 2 3 6 6 6 2 Delta serrate ligand EGF_2 PF07974.13 VDK75360.1 - 0.0064 16.8 11.7 0.0064 16.8 11.7 7.2 7 0 0 7 7 7 5 EGF-like domain TMEM154 PF15102.6 VDK75360.1 - 0.043 13.7 0.6 0.08 12.9 0.6 1.4 1 0 0 1 1 1 0 TMEM154 protein family Lectin_C PF00059.21 VDK75362.1 - 1.8e-14 54.4 0.0 4.8e-14 53.0 0.0 1.8 1 0 0 1 1 1 1 Lectin C-type domain UL45 PF05473.12 VDK75362.1 - 0.00022 20.9 0.1 0.00063 19.4 0.0 1.8 2 0 0 2 2 2 1 UL45 protein, carbohydrate-binding C-type lectin-like YyzF PF14116.6 VDK75362.1 - 0.00098 19.1 0.3 0.22 11.6 0.1 2.7 2 0 0 2 2 2 2 YyzF-like protein EB PF01683.18 VDK75362.1 - 2.3 8.6 40.1 1.6 9.1 7.7 5.5 4 1 1 5 5 5 0 EB module Sld5 PF05916.11 VDK75365.1 - 0.00064 20.2 0.0 0.0017 18.8 0.0 1.7 2 0 0 2 2 2 1 GINS complex protein Acetyltransf_1 PF00583.25 VDK75367.1 - 3.2e-15 56.4 0.0 4.6e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 VDK75367.1 - 1.5e-09 38.2 0.0 2.5e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 VDK75367.1 - 1.7e-09 37.7 0.1 2.8e-09 37.0 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 VDK75367.1 - 4.3e-06 26.6 0.0 7.6e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 VDK75367.1 - 0.0019 17.7 0.6 0.0057 16.1 0.6 1.8 1 1 0 1 1 1 1 Putative acetyl-transferase Glyco_trans_4_3 PF12000.8 VDK75367.1 - 0.0053 16.5 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 4 group Acetyltransf_3 PF13302.7 VDK75367.1 - 0.0062 17.2 0.0 0.011 16.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 VDK75367.1 - 0.024 14.6 0.1 0.044 13.8 0.1 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_9 PF13527.7 VDK75367.1 - 0.025 14.7 0.1 0.044 13.9 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF236 PF03057.14 VDK75368.1 - 3.3e-72 238.1 25.2 8.1e-16 57.7 0.5 5.3 5 0 0 5 5 5 5 DUF236 repeat Tweety PF04906.13 VDK75368.1 - 0.26 9.9 2.7 0.36 9.4 2.7 1.1 1 0 0 1 1 1 0 Tweety Collar PF07484.12 VDK75368.1 - 1 9.4 6.8 4.2 7.5 0.0 4.2 5 0 0 5 5 5 0 Phage Tail Collar Domain BRO1 PF03097.18 VDK75370.1 - 3.8e-28 98.4 0.0 5.4e-28 97.9 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain Fer4_8 PF13183.6 VDK75370.1 - 0.03 14.8 2.3 0.11 13.0 2.3 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 VDK75370.1 - 0.11 12.7 0.3 0.11 12.7 0.3 1.9 2 0 0 2 2 2 0 4Fe-4S dicluster domain Globin PF00042.22 VDK75372.1 - 1.9e-06 28.4 0.0 3.2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Globin DUF4719 PF15843.5 VDK75372.1 - 0.014 15.5 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) MOZ_SAS PF01853.18 VDK75379.1 - 1.4e-78 262.7 0.1 2.2e-78 262.0 0.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 VDK75379.1 - 8.9e-22 76.5 5.8 2.2e-21 75.2 5.8 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 VDK75379.1 - 1.7e-13 50.3 0.5 4.2e-13 49.0 0.1 2.0 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 VDK75379.1 - 0.0033 17.3 0.0 0.0082 16.0 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Acetyltransf_7 PF13508.7 VDK75379.1 - 0.0067 16.8 0.0 0.03 14.7 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DNA_photolyase PF00875.18 VDK75379.1 - 0.076 13.0 1.1 0.14 12.2 0.3 1.8 2 0 0 2 2 2 0 DNA photolyase H_kinase_N PF12282.8 VDK75379.1 - 0.099 12.6 0.2 0.25 11.3 0.2 1.6 1 0 0 1 1 1 0 Signal transduction histidine kinase FR47 PF08445.10 VDK75379.1 - 0.1 12.6 0.0 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 FR47-like protein TFIIF_alpha PF05793.12 VDK75380.1 - 1.4 7.4 16.2 2.6 6.5 16.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM60A PF15396.6 VDK75380.1 - 6.1 6.8 11.2 1.7 8.6 7.0 2.1 2 0 0 2 2 2 0 Protein Family FAM60A GET2 PF08690.10 VDK75380.1 - 6.4 6.3 9.9 0.3 10.7 2.6 2.2 1 1 1 2 2 2 0 GET complex subunit GET2 DUF4637 PF15470.6 VDK75380.1 - 8.2 6.1 12.2 18 5.0 12.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) IBR PF01485.21 VDK75381.1 - 1.6e-11 44.3 15.3 1.6e-11 44.3 15.3 3.8 3 1 0 3 3 3 1 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 VDK75381.1 - 0.019 14.8 7.3 0.019 14.8 7.3 4.2 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF3730 PF12530.8 VDK75383.1 - 0.33 10.5 1.3 0.38 10.3 1.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) Nuc_sug_transp PF04142.15 VDK75384.1 - 7.4e-84 281.6 18.2 1.2e-83 280.9 18.2 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter TMA7 PF09072.10 VDK75384.1 - 6.6e-24 84.5 22.8 1.5e-23 83.3 22.8 1.6 1 0 0 1 1 1 1 Translation machinery associated TMA7 PET PF06297.14 VDK75384.1 - 8e-19 67.7 0.0 1.6e-18 66.8 0.0 1.5 1 0 0 1 1 1 1 PET Domain LIM PF00412.22 VDK75384.1 - 1.7e-18 66.6 41.7 2.3e-12 47.0 9.9 4.6 4 1 0 4 4 4 2 LIM domain EamA PF00892.20 VDK75384.1 - 5.4e-05 23.4 5.4 5.4e-05 23.4 5.4 2.7 3 0 0 3 3 3 1 EamA-like transporter family EmrE PF13536.6 VDK75384.1 - 0.00096 18.8 3.6 0.0017 18.0 3.6 1.3 1 0 0 1 1 1 1 Putative multidrug resistance efflux transporter TMEM234 PF10639.9 VDK75384.1 - 0.091 12.8 2.4 0.23 11.5 2.4 1.7 1 0 0 1 1 1 0 Putative transmembrane family 234 zf-PARP PF00645.18 VDK75384.1 - 9.4 7.2 14.7 9.9 7.1 2.4 3.8 3 0 0 3 3 3 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GDP_Man_Dehyd PF16363.5 VDK75386.1 - 2.3e-160 533.5 0.1 2.6e-160 533.3 0.1 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 VDK75386.1 - 1.6e-77 260.3 0.1 2e-77 259.9 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 VDK75386.1 - 1.9e-06 27.2 0.0 3.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 VDK75386.1 - 2.1e-06 27.1 0.0 3.3e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain TAA-Trp-ring PF15401.6 VDK75386.1 - 0.035 14.5 0.4 0.074 13.5 0.4 1.5 1 0 0 1 1 1 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin NmrA PF05368.13 VDK75386.1 - 0.043 13.4 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 NmrA-like family Ribo_biogen_C PF04034.13 VDK75388.1 - 5.5e-48 161.9 0.0 1.1e-47 161.0 0.0 1.5 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal WD40 PF00400.32 VDK75388.1 - 3.7e-41 138.3 28.6 1.9e-07 31.6 0.5 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 VDK75388.1 - 8.7e-12 44.8 5.4 8.7e-12 44.8 5.4 2.4 2 0 0 2 2 2 1 F-box-like RLI PF04068.15 VDK75388.1 - 5e-11 42.2 0.4 5e-11 42.2 0.4 2.5 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI F-box PF00646.33 VDK75388.1 - 2.6e-09 36.7 5.6 7.2e-09 35.3 5.6 1.9 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 VDK75388.1 - 2.1e-08 33.3 9.7 0.0092 14.7 0.1 4.3 2 1 1 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 VDK75388.1 - 1.5e-05 25.2 7.2 0.026 14.8 1.0 4.3 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 VDK75388.1 - 0.00078 19.3 1.9 0.012 15.5 0.3 2.8 2 0 0 2 2 2 1 F-box Ge1_WD40 PF16529.5 VDK75388.1 - 0.36 9.8 5.9 6 5.7 0.2 3.4 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Methyltransf_11 PF08241.12 VDK75389.1 - 6e-12 46.1 0.0 1.3e-11 45.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK75389.1 - 2.5e-09 37.7 0.2 1.4e-08 35.3 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK75389.1 - 5.7e-07 29.4 0.8 0.00027 20.8 0.0 2.3 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 VDK75389.1 - 2.9e-05 24.7 0.1 0.1 13.4 0.1 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 VDK75389.1 - 0.00021 21.2 0.0 0.00028 20.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 VDK75389.1 - 0.011 15.6 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase CMAS PF02353.20 VDK75389.1 - 0.081 12.2 0.5 5.5 6.2 0.1 2.8 3 0 0 3 3 3 0 Mycolic acid cyclopropane synthetase AtuA PF07287.11 VDK75389.1 - 0.19 10.4 0.0 2.4 6.8 0.0 2.0 2 0 0 2 2 2 0 Acyclic terpene utilisation family protein AtuA Copine PF07002.16 VDK75390.1 - 8.6e-58 195.3 0.0 1.2e-57 194.8 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 VDK75390.1 - 6.6e-09 36.0 0.0 2e-05 24.8 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 VDK75390.1 - 0.0034 17.5 0.0 0.0056 16.8 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus LRR_8 PF13855.6 VDK75391.1 - 4e-41 138.6 26.8 1.9e-12 46.8 0.7 6.7 2 2 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 VDK75391.1 - 1e-19 70.3 35.8 4.3e-06 27.0 2.4 7.4 6 2 2 8 8 8 6 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK75391.1 - 2.2e-17 63.2 3.2 6.6e-11 42.3 0.2 3.5 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 VDK75391.1 - 6e-11 42.2 11.2 2.9e-05 23.6 2.8 4.2 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 VDK75391.1 - 8.1e-07 28.7 38.1 0.72 10.6 1.6 11.6 13 1 0 13 13 13 4 Leucine Rich Repeat LYRIC PF15686.5 VDK75391.1 - 0.21 11.1 0.0 0.31 10.6 0.0 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family LRR_6 PF13516.6 VDK75391.1 - 1.8 8.8 35.6 7.6 6.9 0.1 9.2 10 0 0 10 10 10 0 Leucine Rich repeat Exo_endo_phos PF03372.23 VDK75394.1 - 6.1e-06 25.9 0.0 2e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Nt_Gln_amidase PF09764.9 VDK75397.1 - 7.1e-60 201.8 0.7 1.2e-59 201.0 0.7 1.4 1 0 0 1 1 1 1 N-terminal glutamine amidase tRNA-synt_1b PF00579.25 VDK75397.1 - 6.6e-55 186.5 0.0 9.7e-55 185.9 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) WD40 PF00400.32 VDK75399.1 - 6.7e-15 55.2 5.6 0.00011 22.9 0.1 6.1 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK75399.1 - 1.4e-10 41.3 0.0 0.0011 19.3 0.0 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK75399.1 - 1.2e-05 25.3 0.0 0.0073 16.2 0.0 3.0 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 VDK75399.1 - 6.4e-05 22.8 3.2 0.42 10.6 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 VDK75399.1 - 0.0056 16.3 0.2 1.9 8.2 0.0 3.4 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature PQQ PF01011.21 VDK75399.1 - 0.0065 16.3 0.0 0.024 14.6 0.0 2.0 1 0 0 1 1 1 1 PQQ enzyme repeat Ge1_WD40 PF16529.5 VDK75399.1 - 0.045 12.7 0.0 1.9 7.4 0.0 2.6 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 VDK75399.1 - 0.05 13.2 0.0 0.083 12.5 0.0 1.3 1 0 0 1 1 1 0 PQQ-like domain CPSF_A PF03178.15 VDK75417.1 - 2.2e-60 204.7 0.0 2.5e-60 204.5 0.0 1.0 1 0 0 1 1 1 1 CPSF A subunit region Methyltransf_25 PF13649.6 VDK75418.1 - 9.8e-06 26.2 0.3 0.00011 22.8 0.1 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK75418.1 - 4.5e-05 23.3 0.0 0.00013 21.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK75418.1 - 0.00024 20.7 0.2 0.00055 19.5 0.1 1.6 2 0 0 2 2 2 1 Methyltransferase small domain PCMT PF01135.19 VDK75418.1 - 0.00036 20.4 0.0 0.00064 19.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.12 VDK75418.1 - 0.0011 19.5 0.1 0.0062 17.2 0.1 2.1 2 0 0 2 2 2 1 Methyltransferase domain RrnaAD PF00398.20 VDK75418.1 - 0.004 16.3 0.0 0.0067 15.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PrmA PF06325.13 VDK75418.1 - 0.0059 16.0 0.1 0.01 15.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DREV PF05219.12 VDK75418.1 - 0.037 13.1 0.0 0.071 12.2 0.0 1.4 1 0 0 1 1 1 0 DREV methyltransferase MetW PF07021.12 VDK75418.1 - 0.067 12.8 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 VDK75418.1 - 0.091 13.5 0.1 0.31 11.8 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain DUF498 PF04430.14 VDK75419.1 - 1.7e-22 79.6 0.0 2.5e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Carn_acyltransf PF00755.20 VDK75420.1 - 3.6e-153 511.3 0.0 1.9e-107 360.4 0.0 2.0 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase THEG PF14912.6 VDK75422.1 - 0.082 13.4 0.8 1.2 9.6 0.3 3.0 2 1 0 2 2 2 0 Testicular haploid expressed repeat DUF2151 PF10221.9 VDK75424.1 - 6.4e-154 514.2 0.0 2.6e-153 512.2 0.0 1.8 1 1 0 1 1 1 1 Cell cycle and development regulator zf-CCCH PF00642.24 VDK75425.1 - 9.1e-13 47.8 13.5 3.8e-06 26.7 1.6 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK75425.1 - 5.7e-08 32.6 12.5 0.00059 19.8 1.5 2.7 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 VDK75425.1 - 1.2e-06 29.1 6.8 0.0053 17.5 1.8 2.5 2 0 0 2 2 2 2 Torus domain RRM_1 PF00076.22 VDK75425.1 - 1.3e-05 24.9 0.0 3.8e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 VDK75425.1 - 0.23 11.3 13.6 0.65 9.9 4.4 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger RSB_motif PF16294.5 VDK75427.1 - 3.4e-20 72.2 10.3 3.4e-20 72.2 10.3 6.6 5 1 1 6 6 6 1 RNSP1-SAP18 binding (RSB) motif SAP PF02037.27 VDK75427.1 - 6e-10 38.7 0.9 1.5e-09 37.3 0.6 1.9 2 0 0 2 2 2 1 SAP domain RRM_1 PF00076.22 VDK75427.1 - 0.082 12.7 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAP-gamma PF07074.12 VDK75427.1 - 0.15 11.6 2.6 0.4 10.2 2.6 1.7 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) SNF2_N PF00176.23 VDK75429.1 - 8.4e-58 195.8 0.0 1.8e-57 194.6 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK75429.1 - 2.9e-15 56.6 0.0 1.5e-14 54.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK75429.1 - 1.4e-07 31.7 0.0 8.6e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 VDK75429.1 - 2e-05 24.0 0.1 3.4e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Rad54_N PF08658.10 VDK75429.1 - 4e-05 23.8 0.1 8.4e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Rad54 N terminal Hydrolase_6 PF13344.6 VDK75432.1 - 2.9e-27 94.7 0.0 7.9e-27 93.3 0.0 1.8 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 VDK75432.1 - 3e-16 59.3 0.0 6.4e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 VDK75432.1 - 2.6e-09 37.7 0.0 0.00067 20.0 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 VDK75432.1 - 1.2e-06 28.7 0.0 0.0011 19.1 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 VDK75432.1 - 0.15 11.6 0.0 1.1 8.8 0.0 2.3 3 0 0 3 3 3 0 Mitochondrial PGP phosphatase PRA1 PF03208.19 VDK75434.1 - 1.4e-26 92.9 4.8 1.6e-26 92.6 4.8 1.1 1 0 0 1 1 1 1 PRA1 family protein F-box-like PF12937.7 VDK75435.1 - 0.0026 17.6 1.0 0.03 14.2 0.1 3.0 3 0 0 3 3 3 1 F-box-like Leptin PF02024.15 VDK75435.1 - 0.036 13.8 1.5 0.1 12.3 0.0 2.5 3 1 1 4 4 4 0 Leptin F-box PF00646.33 VDK75435.1 - 0.066 13.1 4.8 0.078 12.9 0.1 3.4 4 0 0 4 4 4 0 F-box domain Arylesterase PF01731.20 VDK75436.1 - 6.2e-15 55.2 1.3 1.4e-14 54.0 0.7 1.9 2 0 0 2 2 2 1 Arylesterase SGL PF08450.12 VDK75436.1 - 0.00022 20.9 0.0 0.00033 20.3 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 VDK75436.1 - 0.0014 18.5 0.0 0.28 11.3 0.0 2.8 2 0 0 2 2 2 2 NHL repeat zf-H2C2_2 PF13465.6 VDK75437.1 - 5.6e-19 67.6 17.7 1.5e-08 34.7 1.2 5.5 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 VDK75437.1 - 4.3e-18 64.7 25.8 1.2e-05 25.5 1.8 4.9 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK75437.1 - 4.1e-13 49.0 22.5 0.0029 18.3 1.3 5.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK75437.1 - 2.9e-06 26.9 0.7 2.9e-06 26.9 0.7 3.8 4 0 0 4 4 3 2 C2H2-type zinc-finger domain zf-Di19 PF05605.12 VDK75437.1 - 0.0037 17.5 11.8 0.6 10.5 2.9 3.5 2 1 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding DUF2225 PF09986.9 VDK75437.1 - 0.022 14.5 4.0 0.037 13.7 0.9 2.6 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DZR PF12773.7 VDK75437.1 - 0.028 14.4 4.5 0.47 10.5 0.8 2.8 2 0 0 2 2 2 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 VDK75437.1 - 0.033 14.3 9.4 0.035 14.2 1.8 2.9 3 0 0 3 3 2 0 Zinc ribbon domain HypA PF01155.19 VDK75437.1 - 0.047 13.7 1.3 19 5.3 0.0 2.5 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_ZHX PF18387.1 VDK75437.1 - 0.063 12.9 10.5 0.91 9.2 2.0 4.0 1 1 3 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_jaz PF12171.8 VDK75437.1 - 0.17 12.2 0.1 0.17 12.2 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 VDK75437.1 - 0.24 12.2 6.5 1.8 9.4 0.8 2.9 1 1 0 2 2 2 0 zinc-ribbon family zf-C2H2_3rep PF18868.1 VDK75437.1 - 0.57 10.9 8.4 0.042 14.5 3.0 2.1 2 0 0 2 2 1 0 Zinc finger C2H2-type, 3 repeats DUF3268 PF11672.8 VDK75437.1 - 0.72 10.2 3.4 4.5 7.6 0.8 2.4 2 0 0 2 2 2 0 zinc-finger-containing domain Zn_ribbon_SprT PF17283.2 VDK75437.1 - 0.78 9.7 11.5 6.2 6.8 0.1 3.8 2 1 0 3 3 3 0 SprT-like zinc ribbon domain zf-met PF12874.7 VDK75437.1 - 1.6 9.2 4.0 34 5.0 0.7 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 VDK75437.1 - 3.9 7.1 7.5 6.8 6.4 0.0 3.7 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger FYVE PF01363.21 VDK75437.1 - 4.7 7.4 13.7 0.46 10.7 5.1 2.9 3 0 0 3 3 2 0 FYVE zinc finger zf-C2H2_2 PF12756.7 VDK75437.1 - 5.1 7.5 14.4 17 5.8 7.5 3.9 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) OrsD PF12013.8 VDK75437.1 - 8.6 6.8 13.1 9.3 6.7 0.6 3.6 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D CBFD_NFYB_HMF PF00808.23 VDK75449.1 - 4.5e-17 62.1 0.1 9.6e-17 61.0 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK75449.1 - 0.0011 19.3 0.9 0.0021 18.4 0.1 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-W PF15510.6 VDK75449.1 - 0.014 15.6 1.2 0.096 12.9 0.1 2.2 2 0 0 2 2 2 0 CENP-W protein MutS_I PF01624.20 VDK75449.1 - 0.019 15.2 0.1 0.12 12.6 0.0 2.0 2 0 0 2 2 2 0 MutS domain I DUF5064 PF16703.5 VDK75449.1 - 0.086 13.3 0.4 4.6 7.8 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5064) zf-MYND PF01753.18 VDK75450.1 - 0.00073 19.6 22.3 0.0013 18.7 22.3 1.5 1 0 0 1 1 1 1 MYND finger DUF5050 PF16472.5 VDK75450.1 - 0.019 14.2 0.1 0.027 13.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) CAP_N PF01213.19 VDK75452.1 - 0.53 9.7 14.8 0.08 12.4 10.5 1.7 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 VDK75452.1 - 0.91 9.6 14.7 0.72 9.9 9.7 2.1 2 0 0 2 2 2 0 Mitochondrial fission regulator FGGY_N PF00370.21 VDK75458.1 - 4.2e-33 114.9 0.1 1.6e-31 109.8 0.1 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 VDK75458.1 - 4.9e-24 85.2 0.0 8.2e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Raco_middle PF17651.1 VDK75458.1 - 0.067 12.9 0.0 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 RACo middle region TPR_2 PF07719.17 VDK75462.1 - 1.1e-32 109.4 3.1 0.00046 20.1 0.1 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 VDK75462.1 - 4e-32 108.7 10.2 6.3e-05 22.6 0.5 7.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 VDK75462.1 - 1.5e-23 82.2 11.3 1.6e-07 30.8 0.1 7.3 5 2 3 8 8 8 6 TPR repeat TPR_9 PF13371.6 VDK75462.1 - 4.7e-20 71.5 0.9 1.6e-05 24.9 0.0 5.2 3 2 2 5 5 5 5 Tetratricopeptide repeat DnaJ PF00226.31 VDK75462.1 - 5.4e-19 68.1 1.7 5.4e-19 68.1 1.7 2.5 3 1 0 3 3 2 1 DnaJ domain TPR_16 PF13432.6 VDK75462.1 - 1.1e-18 67.6 0.8 4.9e-05 23.9 0.0 5.8 4 2 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 VDK75462.1 - 2.8e-18 65.0 2.6 0.005 17.5 0.1 7.5 3 3 5 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDK75462.1 - 3.4e-18 64.3 8.5 0.0028 17.8 0.0 8.1 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 VDK75462.1 - 9.6e-16 57.0 9.5 0.0024 18.1 0.1 7.5 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 VDK75462.1 - 3.7e-15 56.0 3.8 0.0068 16.7 0.1 5.5 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_19 PF14559.6 VDK75462.1 - 9.2e-15 54.9 7.2 0.0011 19.4 0.3 5.7 3 3 3 6 6 6 3 Tetratricopeptide repeat TPR_20 PF14561.6 VDK75462.1 - 3.9e-09 36.7 4.0 0.14 12.5 0.0 4.7 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 VDK75462.1 - 1.1e-07 32.0 6.9 0.98 10.2 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 VDK75462.1 - 7.1e-07 28.7 0.4 2.9 7.0 0.0 5.1 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 VDK75462.1 - 6.9e-06 25.8 5.3 4.8 7.2 0.1 6.1 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 VDK75462.1 - 1.1e-05 25.1 1.9 5.7 7.2 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 VDK75462.1 - 2e-05 24.4 9.2 0.00013 21.8 0.5 3.1 3 1 0 3 3 3 1 Tetratricopeptide repeat-like domain SHNi-TPR PF10516.9 VDK75462.1 - 2.7e-05 23.5 0.7 0.0066 15.9 0.1 3.3 3 0 0 3 3 3 1 SHNi-TPR BTAD PF03704.17 VDK75462.1 - 8.8e-05 23.0 1.5 5.9 7.3 0.0 4.5 2 2 0 3 3 3 1 Bacterial transcriptional activator domain ANAPC3 PF12895.7 VDK75462.1 - 0.00017 21.7 6.2 0.96 9.7 0.1 4.3 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF4736 PF15883.5 VDK75462.1 - 0.024 14.4 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) TPR_4 PF07721.14 VDK75462.1 - 0.027 15.1 0.1 8.9 7.3 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 VDK75462.1 - 0.031 13.2 12.2 0.19 10.6 0.1 3.2 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 MIT PF04212.18 VDK75462.1 - 0.044 13.9 2.3 6 7.0 0.3 4.1 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain FlbT PF07378.11 VDK75462.1 - 0.15 12.2 0.8 3.4 7.7 0.1 2.7 2 0 0 2 2 2 0 Flagellar protein FlbT Sec5 PF15469.6 VDK75462.1 - 4.3 7.1 8.7 8.6 6.1 0.5 3.2 2 2 0 2 2 2 0 Exocyst complex component Sec5 SF3A2 PF16835.5 VDK75463.1 - 1.7e-40 137.3 0.3 2.8e-40 136.6 0.3 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 VDK75463.1 - 4.4e-07 30.1 2.0 4.4e-07 30.1 2.0 1.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 VDK75463.1 - 1.4e-05 25.1 0.7 2.3e-05 24.3 0.7 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein zf-C2H2_jaz PF12171.8 VDK75463.1 - 6.9 7.1 6.3 11 6.4 4.7 2.2 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Lamp PF01299.17 VDK75464.1 - 5e-08 32.9 1.4 6.8e-08 32.5 1.4 1.1 1 0 0 1 1 1 1 Lysosome-associated membrane glycoprotein (Lamp) Syndecan PF01034.20 VDK75464.1 - 5.3 7.0 6.9 0.23 11.4 0.8 1.8 2 0 0 2 2 2 0 Syndecan domain RNase_PH PF01138.21 VDK75465.1 - 5.6e-36 124.0 0.0 4.4e-17 62.8 0.0 2.4 2 0 0 2 2 2 2 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 VDK75465.1 - 1.6e-12 47.3 0.4 7.4e-08 32.3 0.1 2.5 2 0 0 2 2 2 2 3' exoribonuclease family, domain 2 PNPase PF03726.14 VDK75465.1 - 6e-06 26.7 0.0 1.5e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain KH_1 PF00013.29 VDK75465.1 - 0.0043 16.9 0.1 0.0093 15.8 0.1 1.6 1 0 0 1 1 1 1 KH domain S1 PF00575.23 VDK75465.1 - 0.042 14.2 0.0 6.5 7.2 0.0 2.5 2 0 0 2 2 2 0 S1 RNA binding domain DER1 PF04511.15 VDK75465.1 - 0.086 12.8 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Der1-like family PPP4R2 PF09184.11 VDK75466.1 - 3.1e-26 92.7 3.8 5.3e-25 88.6 3.8 2.6 1 1 0 1 1 1 1 PPP4R2 Malate_DH PF12434.8 VDK75466.1 - 0.21 11.7 1.6 0.31 11.1 0.1 2.0 2 0 0 2 2 2 0 Malate dehydrogenase enzyme IBN_N PF03810.19 VDK75468.1 - 1.3e-14 53.8 0.0 3.8e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain DUF3646 PF12362.8 VDK75468.1 - 0.032 14.6 0.0 0.18 12.1 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal Rsbr_N PF08678.10 VDK75468.1 - 0.056 13.5 0.0 0.3 11.2 0.0 2.3 1 0 0 1 1 1 0 Rsbr N terminal TAF6_C PF07571.13 VDK75468.1 - 0.11 12.8 0.0 12 6.4 0.0 4.1 4 1 1 5 5 5 0 TAF6 C-terminal HEAT repeat domain DUF1323 PF07037.11 VDK75468.1 - 0.38 11.1 2.3 4.6 7.7 0.1 3.4 3 0 0 3 3 3 0 Putative transcription regulator (DUF1323) Astro_capsid_p PF12226.8 VDK75468.1 - 0.69 9.0 5.2 1.2 8.2 5.2 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NTS_2 PF15448.6 VDK75470.1 - 0.12 12.8 0.6 0.21 12.0 0.1 1.7 2 0 0 2 2 2 0 N-terminal segments of P. falciparum erythrocyte membrane protein Reg_prop PF07494.11 VDK75482.1 - 0.012 15.8 0.2 3.1 8.3 0.0 3.5 4 0 0 4 4 4 0 Two component regulator propeller WD40 PF00400.32 VDK75482.1 - 0.19 12.6 1.0 1.4 9.9 0.1 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Cupredoxin_1 PF13473.6 VDK75483.1 - 0.088 12.9 0.9 0.16 12.1 0.4 1.6 1 1 0 1 1 1 0 Cupredoxin-like domain DUF2870 PF11069.8 VDK75483.1 - 1.7 9.0 5.1 0.99 9.8 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) Myb_DNA-binding PF00249.31 VDK75484.1 - 0.055 13.7 0.1 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 Myb-like DNA-binding domain SASRP1 PF15160.6 VDK75484.1 - 0.23 11.1 2.2 0.96 9.1 2.2 1.9 1 1 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 SnAPC_2_like PF11035.8 VDK75484.1 - 0.27 11.4 3.6 0.31 11.1 0.0 2.5 3 0 0 3 3 3 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb Peptidase_M24 PF00557.24 VDK75485.1 - 1.1e-39 136.4 0.0 1.7e-39 135.7 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 VDK75485.1 - 2.4e-37 128.5 0.0 4.3e-37 127.7 0.0 1.4 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 VDK75485.1 - 8.7e-23 80.2 0.0 2.7e-22 78.6 0.0 1.9 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 VDK75485.1 - 2.2e-13 51.0 0.0 2.9e-11 44.2 0.0 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain NTP_transf_5 PF14907.6 VDK75485.1 - 0.057 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase ABC_membrane_2 PF06472.15 VDK75486.1 - 4.9e-24 85.2 0.5 7.1e-24 84.7 0.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 VDK75486.1 - 1.4e-12 48.3 0.0 5.2e-06 27.0 0.0 2.3 1 1 0 2 2 2 2 ABC transporter NACHT PF05729.12 VDK75486.1 - 0.00013 21.9 0.0 0.00023 21.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_5 PF07728.14 VDK75486.1 - 0.0051 16.8 0.0 0.0088 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 VDK75486.1 - 0.011 16.1 0.0 0.017 15.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 VDK75486.1 - 0.016 15.0 0.0 0.037 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 VDK75486.1 - 0.024 15.2 0.0 0.039 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 VDK75486.1 - 0.025 14.5 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 VDK75486.1 - 0.026 14.4 0.0 0.078 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RNA_helicase PF00910.22 VDK75486.1 - 0.031 14.7 0.2 0.14 12.5 0.1 2.3 2 1 0 2 2 2 0 RNA helicase AAA_29 PF13555.6 VDK75486.1 - 0.038 13.7 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.6 VDK75486.1 - 0.042 14.0 0.0 0.13 12.4 0.0 1.7 1 1 1 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 VDK75486.1 - 0.062 13.6 0.3 0.62 10.3 0.3 2.2 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 VDK75486.1 - 0.095 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 VDK75486.1 - 0.1 12.1 0.0 0.27 10.7 0.0 1.6 1 1 1 2 2 2 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 VDK75486.1 - 0.12 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 VDK75486.1 - 0.14 11.8 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA12 PF10443.9 VDK75486.1 - 0.18 10.5 0.0 0.28 9.9 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein AAA_11 PF13086.6 VDK75486.1 - 0.2 11.4 0.0 2.2 8.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain Glyco_hydro_20 PF00728.22 VDK75487.1 - 1.4e-79 268.1 0.2 2.5e-79 267.2 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 VDK75487.1 - 6.5e-18 65.7 0.0 1.1e-17 65.0 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 VDK75487.1 - 5.9e-07 30.3 0.0 2e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 UPF0020 PF01170.18 VDK75488.1 - 1.4e-10 41.2 0.2 2.3e-09 37.2 0.2 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_N4_Mtase PF01555.18 VDK75488.1 - 2.4e-07 30.7 0.1 0.00038 20.2 0.0 2.3 2 0 0 2 2 2 2 DNA methylase N6_Mtase PF02384.16 VDK75488.1 - 0.00013 21.4 0.0 0.00036 19.9 0.0 1.6 1 1 0 1 1 1 1 N-6 DNA Methylase Cons_hypoth95 PF03602.15 VDK75488.1 - 0.018 14.7 0.1 0.78 9.4 0.1 2.3 1 1 0 1 1 1 0 Conserved hypothetical protein 95 MethyltransfD12 PF02086.15 VDK75488.1 - 0.019 14.6 0.1 0.67 9.6 0.0 2.3 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_25 PF13649.6 VDK75488.1 - 0.019 15.6 0.0 0.29 11.9 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_15 PF09445.10 VDK75488.1 - 0.099 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 VDK75488.1 - 0.33 10.8 1.3 1.2 8.9 0.1 2.4 2 0 0 2 2 2 0 Methyltransferase domain COMP PF11598.8 VDK75491.1 - 0.23 12.0 0.7 0.45 11.0 0.7 1.4 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein Peptidase_M28 PF04389.17 VDK75493.1 - 9.5e-22 77.7 0.0 1.8e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 VDK75493.1 - 3.7e-13 49.3 0.0 8.4e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 PA domain TFR_dimer PF04253.15 VDK75493.1 - 1.7e-09 37.8 0.1 6.5e-09 35.9 0.1 2.0 1 1 0 1 1 1 1 Transferrin receptor-like dimerisation domain Nicastrin PF05450.15 VDK75493.1 - 0.018 14.5 0.0 0.035 13.6 0.0 1.4 1 0 0 1 1 1 0 Nicastrin Peptidase_M20 PF01546.28 VDK75493.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Na_K-ATPase PF00287.18 VDK75494.1 - 9e-73 244.9 0.0 1e-72 244.7 0.0 1.0 1 0 0 1 1 1 1 Sodium / potassium ATPase beta chain HMG_box PF00505.19 VDK75506.1 - 7.1e-14 52.0 3.8 1.1e-13 51.3 3.8 1.3 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK75506.1 - 2.4e-09 37.6 4.2 4.2e-09 36.9 4.2 1.4 1 0 0 1 1 1 1 HMG-box domain Asparaginase_II PF06089.12 VDK75506.1 - 0.059 12.4 0.0 0.089 11.8 0.0 1.3 1 0 0 1 1 1 0 L-asparaginase II EMC3_TMCO1 PF01956.16 VDK75508.1 - 1.9e-53 180.7 0.4 1.9e-53 180.7 0.4 2.0 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like CotH PF08757.11 VDK75508.1 - 0.0066 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 CotH kinase protein CENP-X PF09415.10 VDK75510.1 - 5.4e-07 29.8 0.0 6.3e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 CENP-S associating Centromere protein X TFIID-18kDa PF02269.16 VDK75510.1 - 0.13 12.3 0.0 0.15 12.1 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit Prefoldin PF02996.17 VDK75512.1 - 2.2e-12 47.0 0.3 3e-12 46.5 0.3 1.3 1 1 0 1 1 1 1 Prefoldin subunit Phosducin PF02114.16 VDK75513.1 - 1.8e-31 109.1 0.1 1.2e-27 96.5 0.0 2.1 1 1 1 2 2 2 2 Phosducin NPR3 PF03666.13 VDK75514.1 - 2.4e-30 105.8 2.9 1e-25 90.5 2.1 3.0 1 1 1 2 2 2 2 Nitrogen Permease regulator of amino acid transport activity 3 Pyr_redox_2 PF07992.14 VDK75515.1 - 5.3e-14 52.1 0.0 2.4e-10 40.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 VDK75515.1 - 0.044 13.8 0.0 0.13 12.2 0.0 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 VDK75515.1 - 0.11 11.7 0.1 0.39 9.9 0.0 1.9 2 0 0 2 2 2 0 Thi4 family NAD_binding_8 PF13450.6 VDK75515.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DUF1242 PF06842.12 VDK75516.1 - 9.6e-19 66.9 1.7 1.8e-18 66.0 1.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) Rpp20 PF12328.8 VDK75516.1 - 1.9e-13 50.6 1.7 4.1e-11 43.0 1.7 2.3 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 VDK75516.1 - 8.8e-11 41.5 0.8 1.8e-10 40.5 0.8 1.6 1 0 0 1 1 1 1 Alba WD40 PF00400.32 VDK75516.1 - 6.4e-07 30.0 1.0 0.06 14.2 0.0 5.0 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK75516.1 - 0.00034 20.8 0.0 2.7 8.4 0.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3512 PF12024.8 VDK75517.1 - 7.1e-54 182.8 0.0 7.1e-54 182.8 0.0 1.8 2 1 1 3 3 3 1 Domain of unknown function (DUF3512) Bromodomain PF00439.25 VDK75517.1 - 8e-23 80.3 0.6 2.8e-22 78.6 0.4 2.0 2 0 0 2 2 2 1 Bromodomain SpoIIIAH PF12685.7 VDK75517.1 - 3 7.6 9.9 5.6 6.7 9.9 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein CDC45 PF02724.14 VDK75517.1 - 3.8 5.7 17.0 5.8 5.1 17.0 1.1 1 0 0 1 1 1 0 CDC45-like protein ABC_membrane PF00664.23 VDK75519.1 - 9.1e-60 202.6 17.2 9.1e-60 202.6 17.2 2.1 3 0 0 3 3 3 1 ABC transporter transmembrane region ABC_tran PF00005.27 VDK75519.1 - 3.6e-32 111.8 0.0 8.6e-32 110.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 VDK75519.1 - 1.5e-11 44.2 2.3 3e-09 36.7 2.3 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 VDK75519.1 - 0.012 15.5 0.0 0.037 13.9 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 VDK75519.1 - 0.019 15.3 0.1 0.11 12.9 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_PrkA PF08298.11 VDK75519.1 - 0.059 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 PrkA AAA domain AAA_5 PF07728.14 VDK75519.1 - 0.1 12.6 0.0 0.74 9.8 0.0 2.4 2 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 VDK75519.1 - 0.1 12.3 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_15 PF13175.6 VDK75519.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain SbcCD_C PF13558.6 VDK75519.1 - 0.16 12.2 0.3 1.9 8.8 0.3 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DOT1 PF08123.13 VDK75523.1 - 1e-61 208.1 0.8 3e-61 206.5 0.1 2.0 2 0 0 2 2 2 1 Histone methylation protein DOT1 bZIP_1 PF00170.21 VDK75523.1 - 0.088 12.9 7.6 7.7 6.7 1.8 4.1 3 0 0 3 3 3 0 bZIP transcription factor HALZ PF02183.18 VDK75523.1 - 0.15 12.3 3.6 3.3 8.0 0.1 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Methyltransf_4 PF02390.17 VDK75523.1 - 0.22 11.0 1.8 0.38 10.2 0.0 2.4 4 0 0 4 4 4 0 Putative methyltransferase Jnk-SapK_ap_N PF09744.9 VDK75523.1 - 5.6 7.2 9.6 40 4.4 9.0 2.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Tropomyosin_1 PF12718.7 VDK75523.1 - 9.8 6.3 11.3 0.22 11.7 2.2 2.5 2 0 0 2 2 2 0 Tropomyosin like FXR_C3 PF16097.5 VDK75524.1 - 0.2 12.4 0.8 1.1 10.0 0.1 2.6 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 3 Ctf8 PF09696.10 VDK75525.1 - 6.9e-08 32.9 5.4 7.8e-05 23.0 2.4 3.1 1 1 1 2 2 2 2 Ctf8 Leo1 PF04004.13 VDK75525.1 - 0.16 11.8 0.0 0.25 11.2 0.0 1.2 1 0 0 1 1 1 0 Leo1-like protein Ge1_WD40 PF16529.5 VDK75526.1 - 2.7e-46 158.1 1.5 2.2e-37 128.7 0.3 2.2 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 VDK75526.1 - 0.0039 17.5 0.0 0.6 10.4 0.0 3.6 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Vps51 PF08700.11 VDK75526.1 - 0.17 12.0 1.8 0.39 10.8 1.8 1.6 1 0 0 1 1 1 0 Vps51/Vps67 Sec7_N PF12783.7 VDK75526.1 - 0.77 9.7 5.4 0.17 11.8 1.6 1.9 2 0 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal PhoLip_ATPase_C PF16212.5 VDK75527.1 - 1.2e-62 211.9 28.3 1.2e-62 211.9 28.3 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 VDK75527.1 - 9.3e-14 52.2 0.8 9.2e-11 42.4 0.8 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 VDK75527.1 - 1.8e-10 40.8 0.0 6.4e-10 39.0 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 VDK75527.1 - 1e-05 25.4 0.4 0.00019 21.3 0.2 2.2 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDK75527.1 - 0.023 15.1 0.1 6.2 7.2 0.0 3.1 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Filamin PF00630.19 VDK75535.1 - 1.2e-07 32.5 0.3 1.3e-06 29.2 0.0 2.6 2 0 0 2 2 2 1 Filamin/ABP280 repeat Big_3_5 PF16640.5 VDK75535.1 - 2.8 8.2 11.7 5.3 7.3 1.6 3.1 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) Filamin PF00630.19 VDK75537.1 - 4.4e-43 146.3 0.2 4.6e-10 40.2 0.0 5.4 5 0 0 5 5 5 5 Filamin/ABP280 repeat DUF5060 PF16586.5 VDK75537.1 - 4.9e-05 23.6 0.0 1.2 9.6 0.0 4.0 4 0 0 4 4 4 2 Domain of unknown function (DUF5060) Invasin_D3 PF09134.10 VDK75537.1 - 0.0025 18.1 0.1 41 4.6 0.0 4.6 4 1 1 5 5 5 1 Invasin, domain 3 UPF0086 PF01868.16 VDK75537.1 - 0.14 12.1 0.0 2.2 8.2 0.0 2.7 1 1 0 1 1 1 0 Domain of unknown function UPF0086 zf-C2HCIx2C PF10782.9 VDK75538.1 - 0.13 12.2 0.1 0.46 10.5 0.1 2.0 1 1 0 1 1 1 0 Zinc-finger Helicase_C PF00271.31 VDK75539.1 - 1.1e-13 51.4 0.1 2.6e-13 50.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 VDK75539.1 - 8.5e-13 48.5 0.0 2.3e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) dsrm PF00035.26 VDK75539.1 - 1.8e-12 47.7 0.0 4.5e-06 27.3 0.0 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif OB_NTP_bind PF07717.16 VDK75539.1 - 7.7e-08 32.6 0.1 2.1e-07 31.2 0.1 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 VDK75539.1 - 1.6e-05 24.7 0.0 4.4e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 VDK75539.1 - 0.0011 19.3 0.0 0.0037 17.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 VDK75539.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain BTB PF00651.31 VDK75540.1 - 0.011 16.0 0.2 0.059 13.6 0.0 2.3 2 1 0 2 2 2 0 BTB/POZ domain Methyltransf_31 PF13847.6 VDK75541.1 - 0.033 14.0 0.1 0.051 13.4 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain Ribonuc_red_sm PF00268.21 VDK75542.1 - 8.4e-114 379.7 4.8 1e-113 379.5 4.8 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ribosomal_L9_N PF01281.19 VDK75544.1 - 0.26 10.9 0.2 0.26 10.9 0.2 2.0 2 0 0 2 2 2 0 Ribosomal protein L9, N-terminal domain MtN3_slv PF03083.16 VDK75565.1 - 2e-14 53.4 19.2 4.5e-08 33.0 1.7 2.5 3 0 0 3 3 3 2 Sugar efflux transporter for intercellular exchange DUF4131 PF13567.6 VDK75565.1 - 7.7 6.1 9.5 0.1 12.2 0.8 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Cystatin PF00031.21 VDK75566.1 - 4e-15 55.8 0.3 6.3e-15 55.2 0.3 1.4 1 1 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 VDK75566.1 - 0.00017 21.9 1.2 0.002 18.4 0.1 2.1 1 1 1 2 2 2 1 Aspartic acid proteinase inhibitor Cwf_Cwc_15 PF04889.12 VDK75574.1 - 1.5e-69 234.5 25.5 2.5e-45 155.2 14.9 2.0 1 1 1 2 2 2 2 Cwf15/Cwc15 cell cycle control protein DUF4407 PF14362.6 VDK75574.1 - 0.76 9.1 9.0 0.97 8.7 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CAMSAP_CC1 PF17095.5 VDK75574.1 - 6.1 6.8 12.9 0.39 10.6 6.3 2.4 2 1 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin XAP5 PF04921.14 VDK75576.1 - 2.3e-65 220.9 5.4 2.3e-65 220.9 5.4 1.9 1 1 1 2 2 2 1 XAP5, circadian clock regulator OmpH PF03938.14 VDK75576.1 - 2.7 8.4 10.4 4.1 7.7 0.9 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4706 PF15797.5 VDK75576.1 - 4.8 7.8 7.2 0.51 10.9 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4706) Mt_ATP-synt_B PF05405.14 VDK75577.1 - 2.8e-18 66.1 3.8 3.4e-18 65.8 3.8 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) ETC_C1_NDUFA5 PF04716.14 VDK75577.1 - 0.15 11.9 0.6 0.31 10.9 0.6 1.6 1 0 0 1 1 1 0 ETC complex I subunit conserved region ChaB PF06150.12 VDK75577.1 - 2.5 8.7 8.7 11 6.6 7.7 2.5 2 1 0 2 2 2 0 ChaB DcpS_C PF11969.8 VDK75579.1 - 0.012 16.1 0.1 0.022 15.2 0.1 1.4 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding DUF4922 PF16269.5 VDK75579.1 - 0.11 12.3 0.0 0.5 10.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4922) IP_trans PF02121.18 VDK75581.1 - 2.4e-89 299.1 1.0 2.8e-89 298.9 1.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Ion_trans_2 PF07885.16 VDK75584.1 - 5.1e-24 84.0 16.6 5.8e-14 51.8 0.2 2.9 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK75584.1 - 0.0026 17.0 8.9 0.0079 15.5 0.1 2.2 2 0 0 2 2 2 2 Ion transport protein WD40 PF00400.32 VDK75586.1 - 6.6e-17 61.6 17.1 0.011 16.6 0.0 7.7 8 0 0 8 8 7 5 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 VDK75586.1 - 3.8e-11 42.6 8.9 3.8e-11 42.6 8.9 2.5 3 0 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK75586.1 - 5.8e-11 42.2 8.8 5.8e-11 42.2 8.8 2.4 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 VDK75586.1 - 5.9e-09 36.1 9.6 5.9e-09 36.1 9.6 2.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 VDK75586.1 - 1.6e-08 34.3 9.0 1.6e-08 34.3 9.0 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 VDK75586.1 - 2.9e-08 33.7 10.7 2.9e-08 33.7 10.7 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING ANAPC4_WD40 PF12894.7 VDK75586.1 - 7.8e-08 32.5 1.5 3.9 7.8 0.0 5.7 2 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_5 PF14634.6 VDK75586.1 - 4.4e-07 29.7 8.1 4.4e-07 29.7 8.1 3.2 3 0 0 3 3 3 1 zinc-RING finger domain WD40_like PF17005.5 VDK75586.1 - 4.1e-06 26.3 0.0 2.3e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 WD40-like domain zf-C3HC4_3 PF13920.6 VDK75586.1 - 5e-06 26.3 5.7 5e-06 26.3 5.7 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 VDK75586.1 - 5.8e-06 26.0 7.0 7.9e-06 25.6 5.0 2.3 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit eIF2A PF08662.11 VDK75586.1 - 0.00016 21.6 0.1 0.1 12.4 0.0 3.4 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 VDK75586.1 - 0.0033 15.8 0.1 0.043 12.1 0.0 2.2 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 VDK75586.1 - 0.0045 15.7 1.9 0.017 13.8 0.1 2.5 1 1 0 2 2 2 1 Nucleoporin Nup120/160 zf-RING_10 PF16685.5 VDK75586.1 - 0.0058 16.7 5.8 0.025 14.7 5.8 2.1 1 0 0 1 1 1 1 zinc RING finger of MSL2 DUF4685 PF15737.5 VDK75586.1 - 0.0062 17.0 0.0 0.018 15.5 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4685) zf-rbx1 PF12678.7 VDK75586.1 - 0.012 15.9 12.5 0.031 14.5 7.9 3.0 2 1 0 2 2 2 0 RING-H2 zinc finger domain U-box PF04564.15 VDK75586.1 - 0.1 12.8 0.1 0.35 11.1 0.0 1.9 2 0 0 2 2 1 0 U-box domain Spectrin PF00435.21 VDK75586.1 - 0.2 12.2 1.9 0.36 11.3 0.0 2.3 3 0 0 3 3 3 0 Spectrin repeat Prok-RING_4 PF14447.6 VDK75586.1 - 0.24 11.3 19.4 0.022 14.6 10.1 3.6 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 VDK75586.1 - 0.27 11.1 10.4 0.038 13.9 5.4 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 VDK75586.1 - 0.52 10.4 8.3 0.79 9.8 0.2 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rad50_zn_hook PF04423.14 VDK75586.1 - 6 6.8 8.3 0.48 10.3 0.3 2.9 3 0 0 3 3 2 0 Rad50 zinc hook motif PTEN_C2 PF10409.9 VDK75588.1 - 8.5e-19 67.6 0.0 1.6e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DnaJ PF00226.31 VDK75588.1 - 5.4e-06 26.4 0.0 1.6e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain RRS1 PF04939.12 VDK75607.1 - 7.8e-51 172.2 8.0 7.8e-51 172.2 8.0 2.1 2 1 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) Allexi_40kDa PF05549.11 VDK75607.1 - 0.15 11.5 0.1 0.15 11.5 0.1 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein tRNA-synt_1g PF09334.11 VDK75608.1 - 5.4e-89 298.7 0.1 1.2e-86 290.9 0.1 2.3 1 1 0 1 1 1 1 tRNA synthetases class I (M) Ku PF02735.16 VDK75608.1 - 3.1e-41 141.3 0.1 6.8e-41 140.2 0.1 1.6 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain tRNA-synt_1 PF00133.22 VDK75608.1 - 4.6e-14 51.6 0.2 3.8e-06 25.4 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Ku_N PF03731.15 VDK75608.1 - 2.3e-12 47.1 0.8 8.4e-12 45.3 0.8 2.0 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Methyltransf_11 PF08241.12 VDK75608.1 - 3.3e-11 43.7 0.0 1.6e-10 41.5 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK75608.1 - 4.5e-11 43.3 0.0 1.9e-10 41.3 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_6 PF13405.6 VDK75608.1 - 6.6e-07 28.8 1.4 0.075 13.0 0.2 4.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 VDK75608.1 - 1.6e-06 28.5 3.4 0.11 13.0 0.1 4.3 2 1 0 2 2 2 2 EF-hand domain pair Anticodon_1 PF08264.13 VDK75608.1 - 5e-06 26.5 0.0 1.3e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Ubie_methyltran PF01209.18 VDK75608.1 - 7.9e-06 25.4 0.0 0.00011 21.7 0.0 2.3 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family EF-hand_13 PF17958.1 VDK75608.1 - 1e-05 25.3 0.1 0.0011 18.7 0.1 2.8 2 0 0 2 2 2 1 EF-hand domain Methyltransf_31 PF13847.6 VDK75608.1 - 1.8e-05 24.6 0.0 5e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ku_C PF03730.14 VDK75608.1 - 6.6e-05 23.5 0.3 0.0003 21.4 0.3 2.2 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm EF-hand_1 PF00036.32 VDK75608.1 - 7.6e-05 22.0 0.8 0.076 12.6 0.1 3.2 2 0 0 2 2 2 2 EF hand Methyltransf_23 PF13489.6 VDK75608.1 - 0.00018 21.4 0.0 0.00043 20.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 VDK75608.1 - 0.0002 21.2 0.0 0.00044 20.1 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) EF-hand_5 PF13202.6 VDK75608.1 - 0.00096 18.5 0.3 2 8.0 0.0 3.0 2 0 0 2 2 2 2 EF hand tRNA-synt_1e PF01406.19 VDK75608.1 - 0.0019 17.6 0.0 0.082 12.2 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 VDK75608.1 - 0.016 14.1 0.0 0.041 12.8 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (K) SPARC_Ca_bdg PF10591.9 VDK75608.1 - 0.024 14.9 0.6 1.6 9.1 0.0 3.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region VWA_2 PF13519.6 VDK75608.1 - 0.032 14.9 0.0 0.19 12.4 0.0 2.4 2 0 0 2 2 2 0 von Willebrand factor type A domain PHD PF00628.29 VDK75609.1 - 7.8e-07 28.9 9.0 1.7e-06 27.8 9.0 1.6 1 0 0 1 1 1 1 PHD-finger WHIM1 PF15612.6 VDK75609.1 - 0.1 12.2 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 zf-CHY PF05495.12 VDK75609.1 - 0.12 12.8 2.8 0.32 11.5 2.8 1.7 1 0 0 1 1 1 0 CHY zinc finger Epimerase PF01370.21 VDK75610.1 - 7.2e-14 51.8 0.1 3.4e-12 46.4 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 VDK75610.1 - 6.1e-11 41.8 0.0 3.4e-06 26.3 0.0 2.1 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 VDK75610.1 - 8e-08 32.0 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 VDK75610.1 - 2.2e-07 30.7 0.0 0.00036 20.2 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family NAD_binding_4 PF07993.12 VDK75610.1 - 2.3e-07 30.2 0.1 0.018 14.2 0.0 3.0 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 VDK75610.1 - 2.5e-06 27.5 0.0 4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 VDK75610.1 - 0.012 15.1 0.0 0.033 13.6 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase TFIIA PF03153.13 VDK75611.1 - 4.8 7.1 15.3 7 6.5 15.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase_Tyr PF07714.17 VDK75613.1 - 7.1e-90 300.8 0.2 9e-90 300.5 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK75613.1 - 9.9e-50 169.3 0.5 6.2e-49 166.7 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 VDK75613.1 - 1.2e-14 54.1 0.0 1.1e-13 51.1 0.0 2.3 2 0 0 2 2 2 1 SH2 domain Kinase-like PF14531.6 VDK75613.1 - 0.00071 19.0 0.1 0.036 13.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 VDK75613.1 - 0.036 13.4 0.7 0.091 12.1 0.7 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family A_deaminase PF00962.22 VDK75615.1 - 7.4e-114 380.5 0.3 1.1e-113 380.0 0.3 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Pkinase PF00069.25 VDK75616.1 - 3.1e-70 236.6 0.0 4.3e-70 236.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK75616.1 - 1.1e-50 172.3 0.0 1.6e-50 171.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK75616.1 - 0.00025 20.0 0.0 0.00054 18.9 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 VDK75616.1 - 0.00077 18.9 0.0 0.011 15.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like DUF1241 PF06840.11 VDK75616.1 - 0.002 17.8 0.0 0.0058 16.3 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) Haspin_kinase PF12330.8 VDK75616.1 - 0.059 12.3 0.2 0.38 9.6 0.2 2.1 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 VDK75616.1 - 0.087 12.7 0.0 2.1 8.2 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Metallophos PF00149.28 VDK75626.1 - 2.7e-13 50.9 0.6 6.1e-13 49.7 0.6 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 VDK75626.1 - 2.3e-06 27.9 0.0 4.7e-06 26.9 0.0 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain GST_C_3 PF14497.6 VDK75627.1 - 2.1e-14 53.5 0.0 3.3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 VDK75627.1 - 2.8e-14 53.2 0.0 5.3e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 VDK75627.1 - 3.9e-08 33.6 0.0 6.7e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 VDK75627.1 - 3.1e-06 27.3 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 VDK75627.1 - 0.00014 22.1 0.0 0.00024 21.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 VDK75627.1 - 0.00025 21.0 0.0 0.00049 20.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 VDK75627.1 - 0.0032 18.2 0.0 0.011 16.5 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase N-terminal domain Mito_carr PF00153.27 VDK75629.1 - 5.7e-61 202.5 1.3 1.9e-20 72.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein COPIIcoated_ERV PF07970.12 VDK75630.1 - 2e-26 93.2 1.7 2.1e-26 93.2 0.1 1.7 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 VDK75630.1 - 7.3e-12 45.5 0.0 1.6e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Patched PF02460.18 VDK75632.1 - 2.9e-171 571.4 17.5 1.3e-168 562.7 7.1 2.9 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK75632.1 - 1.7e-27 96.1 2.7 1.7e-27 96.1 2.7 3.2 2 2 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation Asn_synthase PF00733.21 VDK75634.1 - 7.3e-17 62.1 0.1 4.1e-06 26.7 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 VDK75634.1 - 9.7e-06 25.5 0.0 3.2e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 VDK75634.1 - 0.039 14.2 0.0 0.21 11.8 0.0 2.0 2 0 0 2 2 2 0 Glutamine amidotransferase domain ATP_bind_3 PF01171.20 VDK75634.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 PP-loop family TPR_8 PF13181.6 VDK75636.1 - 5.2e-27 91.8 12.8 0.00053 20.0 0.1 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 VDK75636.1 - 8.5e-26 88.0 16.4 0.0055 16.7 0.1 9.4 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_1 PF00515.28 VDK75636.1 - 4e-25 86.6 21.5 0.0021 17.8 0.0 9.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 VDK75636.1 - 3.3e-14 52.9 17.0 0.068 13.5 1.3 8.3 4 4 3 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 VDK75636.1 - 5.5e-14 51.6 9.8 0.00031 20.4 0.0 7.2 5 1 2 7 7 7 2 TPR repeat TPR_17 PF13431.6 VDK75636.1 - 2.8e-11 43.0 16.8 0.027 14.8 0.1 8.0 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 VDK75636.1 - 1.8e-08 34.5 9.8 0.38 11.7 0.3 7.4 6 2 2 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK75636.1 - 2.4e-08 34.5 3.8 0.38 11.4 0.0 5.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 VDK75636.1 - 1.8e-07 30.7 6.3 1.5 9.1 0.1 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK75636.1 - 2.6e-06 27.8 16.5 0.6 10.7 3.9 5.9 4 3 4 8 8 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 VDK75636.1 - 2e-05 24.7 8.1 0.021 15.0 0.1 5.3 3 2 2 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK75636.1 - 0.00014 22.1 14.1 0.1 12.8 0.2 5.2 2 2 4 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 VDK75636.1 - 0.031 14.9 9.2 1.8 9.4 0.0 6.2 8 0 0 8 8 7 0 Tetratricopeptide repeat PTS_EIIA_2 PF00359.22 VDK75636.1 - 0.047 13.6 0.4 1.4 8.9 0.1 2.6 2 1 1 3 3 3 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 BEX PF04538.12 VDK75636.1 - 0.11 13.1 0.3 0.29 11.7 0.3 1.7 1 0 0 1 1 1 0 Brain expressed X-linked like family TPR_10 PF13374.6 VDK75636.1 - 1.5 8.8 12.1 35 4.4 0.3 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat RRM_1 PF00076.22 VDK75638.1 - 1.1e-29 102.1 0.0 4.1e-16 58.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK75638.1 - 9.6e-09 35.2 0.2 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 2 RNA binding motif RRM_occluded PF16842.5 VDK75638.1 - 0.0076 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 VDK75638.1 - 0.041 14.0 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif CH PF00307.31 VDK75641.1 - 4e-82 271.5 2.6 1.4e-20 73.4 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK75641.1 - 4.8e-07 29.5 0.4 0.0031 17.3 0.1 3.0 3 0 0 3 3 3 2 CAMSAP CH domain Sigma70_r1_2 PF00140.20 VDK75641.1 - 0.088 12.8 0.0 0.27 11.3 0.0 1.9 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 P5CR_dimer PF14748.6 VDK75644.1 - 5.3e-33 113.4 0.9 5.3e-33 113.4 0.9 2.0 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 VDK75644.1 - 2.1e-12 47.5 0.1 4.5e-12 46.4 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent MtN3_slv PF03083.16 VDK75646.1 - 3.5e-35 119.9 11.5 6.3e-26 90.2 1.3 2.4 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange Rrf2 PF02082.20 VDK75647.1 - 0.0065 16.8 0.1 0.54 10.6 0.0 2.3 1 1 1 2 2 2 2 Transcriptional regulator AsmA PF05170.14 VDK75647.1 - 0.064 12.1 0.0 0.077 11.8 0.0 1.1 1 0 0 1 1 1 0 AsmA family ASC PF00858.24 VDK75647.1 - 0.12 11.3 1.8 0.22 10.4 1.8 1.4 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel 2OG-FeII_Oxy_3 PF13640.6 VDK75664.1 - 0.00033 21.5 0.0 0.00046 21.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2193 PF09959.9 VDK75664.1 - 0.058 11.8 0.2 0.072 11.5 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) GIDA PF01134.22 VDK75666.1 - 9.8e-137 456.2 0.0 1.2e-136 455.9 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 VDK75666.1 - 3.6e-59 200.5 0.0 5.2e-59 200.0 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 VDK75666.1 - 4.7e-06 26.1 0.4 2e-05 24.0 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 VDK75666.1 - 3e-05 23.6 1.3 5.7e-05 22.6 0.4 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 VDK75666.1 - 0.00012 21.3 0.7 0.00025 20.2 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 VDK75666.1 - 0.00047 19.0 1.4 0.039 12.7 0.2 2.6 3 0 0 3 3 3 2 HI0933-like protein AlaDh_PNT_C PF01262.21 VDK75666.1 - 0.0026 17.1 0.0 0.0052 16.1 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 VDK75666.1 - 0.015 15.8 0.1 0.033 14.7 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 VDK75666.1 - 0.12 12.6 0.8 0.35 11.1 0.8 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 VDK75666.1 - 0.17 10.9 0.7 0.38 9.8 0.3 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein DAO PF01266.24 VDK75666.1 - 1.5 8.3 4.2 2.8 7.5 1.9 2.3 2 1 0 3 3 3 0 FAD dependent oxidoreductase DCX PF03607.17 VDK75667.1 - 3e-11 43.2 0.0 6.6e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Doublecortin DUF1794 PF08768.11 VDK75669.1 - 9.4e-28 97.0 0.1 1.2e-27 96.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) ShK PF01549.24 VDK75669.1 - 3.9e-05 24.1 6.9 7.2e-05 23.2 6.9 1.5 1 0 0 1 1 1 1 ShK domain-like Toxin_TOLIP PF00087.21 VDK75669.1 - 0.083 13.1 2.6 0.19 12.0 2.6 1.6 1 0 0 1 1 1 0 Snake toxin and toxin-like protein DUF148 PF02520.17 VDK75670.1 - 2.8e-09 37.1 4.3 4.5e-09 36.4 4.3 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF148 PIN_8 PF18476.1 VDK75670.1 - 0.083 12.7 4.4 0.13 12.2 4.4 1.2 1 0 0 1 1 1 0 PIN like domain p450 PF00067.22 VDK75671.1 - 2.2e-104 349.8 0.0 2.5e-104 349.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_1 PF00561.20 VDK75672.1 - 1.8e-05 24.5 0.0 3.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 VDK75672.1 - 0.00032 20.6 0.0 0.00051 19.9 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 VDK75672.1 - 0.00069 20.3 0.0 0.0011 19.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 VDK75672.1 - 0.023 14.0 0.0 0.13 11.5 0.0 2.0 1 1 0 1 1 1 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 VDK75672.1 - 0.036 13.8 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DUF818 PF05677.12 VDK75672.1 - 0.047 12.6 0.0 6.1 5.7 0.0 2.2 2 0 0 2 2 2 0 Chlamydia CHLPS protein (DUF818) DLH PF01738.18 VDK75672.1 - 0.049 13.2 0.0 0.069 12.7 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Ser_hydrolase PF06821.13 VDK75672.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase Thioesterase PF00975.20 VDK75672.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain zf-CCCH PF00642.24 VDK75673.1 - 6.5e-18 64.2 10.3 8.3e-09 35.2 1.9 2.8 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK75673.1 - 6.3e-11 42.0 16.4 9.9e-06 25.4 2.3 2.9 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 VDK75673.1 - 7.6e-08 32.0 10.6 0.00053 19.7 2.6 2.6 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 VDK75673.1 - 5e-05 23.6 10.0 0.04 14.4 1.3 3.0 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 VDK75673.1 - 0.052 14.3 11.8 0.37 11.5 1.0 2.7 2 1 1 3 3 3 0 Torus domain DUF3331 PF11811.8 VDK75673.1 - 0.095 12.6 0.2 3.6 7.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3331) v110 PF01639.17 VDK75673.1 - 0.14 12.0 5.7 0.46 10.4 0.5 2.8 1 1 0 2 2 2 0 Viral family 110 oligo_HPY PF08352.12 VDK75673.1 - 0.66 10.5 4.0 1.7 9.3 0.5 2.6 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region CPL PF08144.11 VDK75674.1 - 2.8e-25 89.3 0.0 5.7e-22 78.6 0.0 4.0 2 1 1 3 3 3 2 CPL (NUC119) domain PLN_propep PF16485.5 VDK75674.1 - 0.1 12.4 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 Protealysin propeptide EamA PF00892.20 VDK75675.1 - 4e-13 49.7 36.7 1.6e-06 28.3 10.0 3.9 3 2 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 VDK75675.1 - 7.1e-09 35.3 5.9 1.1e-08 34.7 0.4 2.3 2 1 0 2 2 2 1 Nucleotide-sugar transporter TPT PF03151.16 VDK75675.1 - 3.1e-06 26.8 9.7 5.6e-06 25.9 9.5 1.7 1 1 0 1 1 1 1 Triose-phosphate Transporter family SLC35F PF06027.12 VDK75675.1 - 8.6e-06 25.5 16.4 3.7e-05 23.4 5.3 2.5 3 0 0 3 3 3 2 Solute carrier family 35 CRT-like PF08627.10 VDK75675.1 - 0.0025 16.8 6.5 0.0025 16.8 6.5 2.7 3 0 0 3 3 3 2 CRT-like, chloroquine-resistance transporter-like TMEM234 PF10639.9 VDK75675.1 - 0.065 13.3 2.3 0.24 11.4 0.2 2.5 2 0 0 2 2 2 0 Putative transmembrane family 234 Multi_Drug_Res PF00893.19 VDK75675.1 - 0.076 13.7 5.5 5.1 7.8 0.5 3.1 2 0 0 2 2 2 0 Small Multidrug Resistance protein tRNA-synt_1d PF00750.19 VDK75676.1 - 1.2e-57 195.4 1.4 1.6e-57 195.0 1.4 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 VDK75676.1 - 5.9e-16 58.7 0.0 1.8e-15 57.2 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain PRKCSH-like PF12999.7 VDK75677.1 - 6.5e-38 130.3 11.3 6.5e-38 130.3 11.3 2.2 1 1 1 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 VDK75677.1 - 1.5e-25 89.7 1.6 2.4e-25 89.0 0.4 2.0 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein EF-hand_5 PF13202.6 VDK75677.1 - 5.2e-08 32.0 1.2 0.0014 18.0 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 VDK75677.1 - 1e-07 30.9 1.8 0.0014 18.0 0.0 2.7 1 1 1 2 2 2 2 EF hand EF-hand_8 PF13833.6 VDK75677.1 - 2.1e-07 30.7 0.2 0.01 15.7 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 VDK75677.1 - 3e-07 29.8 0.8 0.0019 18.0 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 VDK75677.1 - 3.7e-06 27.3 5.2 0.00045 20.6 0.6 3.0 1 1 1 2 2 2 2 EF-hand domain pair PRKCSH PF07915.13 VDK75677.1 - 2.8e-05 25.0 0.5 2.8e-05 25.0 0.5 2.6 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Ldl_recept_a PF00057.18 VDK75677.1 - 0.01 16.0 18.3 0.054 13.7 2.0 2.8 2 1 0 2 2 2 0 Low-density lipoprotein receptor domain class A EF-hand_10 PF14788.6 VDK75677.1 - 0.02 14.8 0.9 5.7 6.9 0.1 2.9 1 1 1 2 2 2 0 EF hand DUF3437 PF11919.8 VDK75677.1 - 0.29 11.1 0.9 0.58 10.1 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) Peptidase_M13 PF01431.21 VDK75677.1 - 0.3 10.7 2.2 0.41 10.2 0.6 1.9 2 0 0 2 2 2 0 Peptidase family M13 Y_phosphatase PF00102.27 VDK75678.1 - 3.3e-58 197.0 0.0 4.2e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK75678.1 - 0.0031 17.3 0.0 0.0061 16.4 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Beta-lactamase PF00144.24 VDK75679.1 - 3.9e-60 203.8 0.0 3.8e-59 200.6 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase DOPA_dioxygen PF08883.11 VDK75679.1 - 0.05 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Dopa 4,5-dioxygenase family YoaP PF14268.6 VDK75679.1 - 0.16 11.5 0.0 0.35 10.4 0.0 1.5 1 0 0 1 1 1 0 YoaP-like Y_phosphatase PF00102.27 VDK75685.1 - 7.9e-78 261.3 0.0 1.1e-77 260.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK75685.1 - 0.0086 15.9 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ODV-E18 PF10717.9 VDK75700.1 - 0.095 12.6 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Shisa PF13908.6 VDK75700.1 - 3.2 8.0 8.5 1.1 9.5 5.7 1.6 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator LSR PF05624.14 VDK75703.1 - 0.045 13.7 2.6 0.098 12.7 2.6 1.6 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) PIRT PF15099.6 VDK75703.1 - 0.067 12.8 0.7 3.2 7.3 0.0 2.1 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family GBP PF02263.19 VDK75705.1 - 3.7e-50 170.6 0.0 5.6e-50 170.0 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain AflR PF08493.10 VDK75705.1 - 0.06 12.8 0.0 1.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Aflatoxin regulatory protein DKCLD PF08068.12 VDK75705.1 - 0.065 13.3 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 DKCLD (NUC011) domain Phage_holin_2_4 PF16082.5 VDK75705.1 - 0.1 12.3 1.4 0.21 11.4 1.4 1.4 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Ras PF00071.22 VDK75706.1 - 2e-38 131.6 0.0 2.2e-38 131.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK75706.1 - 2.1e-13 50.6 0.0 3.7e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 VDK75706.1 - 0.00011 21.9 0.0 0.00014 21.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 VDK75706.1 - 0.00016 21.2 0.0 0.00036 20.0 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family LAG1-DNAbind PF09271.11 VDK75706.1 - 0.031 14.9 0.1 0.04 14.5 0.1 1.1 1 0 0 1 1 1 0 LAG1, DNA binding HGTP_anticodon PF03129.20 VDK75706.1 - 0.034 14.3 0.0 0.058 13.5 0.0 1.3 1 0 0 1 1 1 0 Anticodon binding domain Ras PF00071.22 VDK75707.1 - 1.2e-57 194.1 0.0 1.4e-57 193.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK75707.1 - 3.4e-23 82.1 0.0 6e-23 81.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK75707.1 - 2.8e-10 39.9 0.0 5.7e-10 38.9 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK75707.1 - 0.00067 19.2 0.0 0.0013 18.4 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 VDK75707.1 - 0.016 14.7 0.2 0.061 12.7 0.0 2.0 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 VDK75707.1 - 0.041 14.1 0.1 2.1 8.6 0.2 2.1 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 VDK75707.1 - 0.058 12.7 0.0 0.08 12.3 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Tetraspanin PF00335.20 VDK75709.1 - 1.2e-39 136.4 14.8 1.7e-39 135.9 14.8 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF3328 PF11807.8 VDK75709.1 - 0.33 10.7 0.1 0.33 10.7 0.1 2.7 3 1 1 4 4 4 0 Domain of unknown function (DUF3328) Ets PF00178.22 VDK75710.1 - 5.2e-30 103.7 0.0 1.2e-29 102.6 0.0 1.6 1 0 0 1 1 1 1 Ets-domain SAM_PNT PF02198.16 VDK75710.1 - 3.5e-08 33.3 0.1 1.2e-07 31.6 0.1 1.9 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Frag1 PF10277.9 VDK75712.1 - 5.5e-45 153.6 13.6 6.3e-45 153.4 13.6 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family COX15-CtaA PF02628.15 VDK75712.1 - 7.6e-05 21.9 0.2 7.6e-05 21.9 0.2 1.4 2 0 0 2 2 2 1 Cytochrome oxidase assembly protein ATG13 PF10033.9 VDK75713.1 - 0.0043 16.8 0.0 0.036 13.7 0.0 2.4 1 1 1 2 2 2 1 Autophagy-related protein 13 FANCI_HD1 PF14679.6 VDK75713.1 - 0.19 11.7 0.2 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 FANCI helical domain 1 EGF PF00008.27 VDK75716.1 - 6.4e-06 26.4 3.5 2.2e-05 24.7 3.5 2.0 1 0 0 1 1 1 1 EGF-like domain DUF1794 PF08768.11 VDK75716.1 - 0.00013 22.0 0.0 0.00017 21.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) EGF_2 PF07974.13 VDK75716.1 - 0.00023 21.4 4.7 0.00023 21.4 4.7 2.1 2 0 0 2 2 2 1 EGF-like domain ShK PF01549.24 VDK75716.1 - 0.0012 19.3 7.6 0.0012 19.3 7.6 2.0 1 1 1 2 2 2 1 ShK domain-like hEGF PF12661.7 VDK75716.1 - 0.012 16.2 5.9 0.012 16.2 5.9 2.2 2 0 0 2 2 2 0 Human growth factor-like EGF MRP-L27 PF09809.9 VDK75722.1 - 1.1e-09 38.1 0.0 6e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L27 Lipase_GDSL_2 PF13472.6 VDK75722.1 - 4.9e-09 36.8 0.0 9.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 VDK75722.1 - 9.6e-05 22.4 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 VDK75722.1 - 0.038 14.1 0.0 0.08 13.1 0.0 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family PNMA PF14893.6 VDK75722.1 - 0.096 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 PNMA SHP PF03579.13 VDK75734.1 - 1.5 8.9 9.9 0.58 10.2 2.2 2.7 1 1 1 2 2 2 0 Small hydrophobic protein Patched PF02460.18 VDK75735.1 - 6.8e-275 914.2 16.8 8e-275 914.0 16.8 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK75735.1 - 1e-38 132.5 6.7 1e-38 132.5 6.7 2.8 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Cyclin_N PF00134.23 VDK75736.1 - 4.6e-15 55.5 3.0 5.4e-13 48.8 1.7 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain CAP_GLY PF01302.25 VDK75737.1 - 2e-19 69.3 1.0 3.4e-19 68.6 1.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_9 PF14580.6 VDK75737.1 - 5.5e-09 35.8 0.1 2.8e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 VDK75737.1 - 9.3e-07 29.1 12.6 0.012 16.1 1.1 5.2 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 VDK75737.1 - 4e-06 26.5 5.1 0.048 13.4 0.0 4.5 3 2 0 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 VDK75737.1 - 1.9 8.7 5.0 44 4.5 0.0 4.1 4 0 0 4 4 4 0 Leucine Rich repeat Pkinase_Tyr PF07714.17 VDK75739.1 - 9.9e-51 172.5 0.0 3.7e-50 170.6 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK75739.1 - 1.8e-50 171.8 0.0 3.8e-50 170.7 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH3_9 PF14604.6 VDK75739.1 - 1.3e-13 50.5 0.1 2.6e-13 49.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK75739.1 - 1.4e-12 47.0 0.6 2.8e-12 46.0 0.6 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK75739.1 - 8.1e-10 38.2 0.2 1.9e-09 37.0 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain Kdo PF06293.14 VDK75739.1 - 0.016 14.5 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 VDK75739.1 - 0.086 11.6 0.2 0.22 10.2 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase TUG-UBL1 PF11470.8 VDK75741.1 - 8.5e-20 70.8 0.2 2.6e-19 69.2 0.2 1.9 1 0 0 1 1 1 1 TUG ubiquitin-like domain RBD PF02196.15 VDK75741.1 - 7.8e-06 25.9 0.3 3.5e-05 23.8 0.3 2.2 2 0 0 2 2 2 1 Raf-like Ras-binding domain UBX PF00789.20 VDK75741.1 - 0.046 13.9 0.4 0.71 10.1 0.0 3.0 3 0 0 3 3 3 0 UBX domain ubiquitin PF00240.23 VDK75741.1 - 0.047 13.4 0.0 0.15 11.8 0.0 1.9 1 0 0 1 1 1 0 Ubiquitin family Rad60-SLD PF11976.8 VDK75741.1 - 0.088 12.6 0.0 0.3 11.0 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4503 PF14951.6 VDK75743.1 - 0.015 13.8 0.1 0.016 13.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) DUF155 PF02582.14 VDK75743.1 - 0.068 13.3 0.3 0.11 12.5 0.2 1.4 1 1 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 HELP PF03451.14 VDK75744.1 - 2.8e-20 72.0 0.0 4.6e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 VDK75744.1 - 9.2e-17 61.1 16.3 0.15 13.0 0.0 11.5 12 0 0 12 12 12 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK75744.1 - 8.7e-11 42.0 2.8 0.17 12.2 0.0 6.5 3 2 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK75744.1 - 0.029 13.7 3.5 0.42 9.9 0.0 3.4 4 1 1 5 5 5 0 WD40-like domain PQQ_2 PF13360.6 VDK75744.1 - 0.07 12.7 0.1 0.53 9.8 0.0 2.3 2 1 0 2 2 2 0 PQQ-like domain DUF740 PF05340.12 VDK75744.1 - 0.19 10.5 0.0 0.28 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Ground-like PF04155.18 VDK75745.1 - 2e-22 79.6 0.6 4.6e-22 78.5 0.6 1.6 1 0 0 1 1 1 1 Ground-like domain HSP20 PF00011.21 VDK75747.1 - 3.2e-22 78.6 0.3 4.1e-22 78.3 0.3 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK75747.1 - 8.6e-06 25.2 0.1 1.4e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA fn3 PF00041.21 VDK75759.1 - 9.8e-277 894.3 135.7 2.9e-13 50.0 0.0 39.0 39 1 0 39 39 39 36 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK75759.1 - 4.8e-57 190.5 80.1 0.00089 19.8 0.0 31.5 33 1 0 33 33 33 15 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 VDK75759.1 - 7.8e-18 64.7 4.5 6.2 7.2 0.0 18.6 21 0 0 21 21 21 1 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 VDK75759.1 - 1.6e-13 50.8 0.6 1.7 9.1 0.0 11.7 13 0 0 13 13 11 2 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 VDK75759.1 - 7.2e-06 26.1 2.2 12 6.2 0.0 9.0 11 0 0 11 11 10 1 Fibronectin type III domain F5_F8_type_C PF00754.25 VDK75759.1 - 1.4e-05 25.2 30.5 0.59 10.3 0.2 10.7 10 2 2 12 12 11 2 F5/8 type C domain Arylsulfotran_N PF17425.2 VDK75759.1 - 5.9e-05 23.0 3.1 1.9 8.6 0.1 5.9 5 0 0 5 5 5 1 Arylsulfotransferase Ig-like domain PhoD_N PF16655.5 VDK75759.1 - 0.0029 18.1 6.5 1.5 9.4 0.0 7.8 10 0 0 10 10 7 1 PhoD-like phosphatase, N-terminal domain COR PF16095.5 VDK75759.1 - 0.079 12.8 0.2 0.19 11.5 0.2 1.6 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain Big_5 PF13205.6 VDK75759.1 - 0.13 13.0 14.5 0.57 10.9 0.2 8.4 10 1 0 10 10 8 0 Bacterial Ig-like domain Gcd10p PF04189.13 VDK75759.1 - 3.9 6.5 6.7 6.7 5.7 6.7 1.3 1 0 0 1 1 1 0 Gcd10p family DUF4381 PF14316.6 VDK75760.1 - 0.002 18.4 4.0 0.0024 18.1 2.3 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4381) TMEM52 PF14979.6 VDK75760.1 - 0.1 12.5 0.2 0.19 11.7 0.2 1.3 1 0 0 1 1 1 0 Transmembrane 52 DUF4131 PF13567.6 VDK75760.1 - 1.4 8.6 5.6 2.6 7.7 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Collagen PF01391.18 VDK75761.1 - 1.7e-25 88.5 97.2 5.8e-10 38.8 27.2 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK75761.1 - 6.6e-14 51.7 2.3 9.5e-14 51.2 2.3 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Ag332 PF04671.12 VDK75763.1 - 0.066 13.1 0.5 0.22 11.5 0.5 1.9 1 0 0 1 1 1 0 Erythrocyte membrane-associated giant protein antigen 332 TMEM52 PF14979.6 VDK75763.1 - 3.4 7.6 4.5 0.65 9.9 0.1 2.1 2 0 0 2 2 2 0 Transmembrane 52 RED_N PF07808.13 VDK75764.1 - 5.1e-72 242.3 9.6 5.1e-72 242.3 9.6 3.3 2 1 1 3 3 3 1 RED-like protein N-terminal region RED_C PF07807.11 VDK75764.1 - 1.9e-43 147.4 7.4 1.9e-43 147.4 7.4 3.0 3 1 1 4 4 4 1 RED-like protein C-terminal region Glyco_hydro_2_N PF02837.18 VDK75765.1 - 0.0047 16.8 0.8 0.018 15.0 0.1 2.0 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain T-box PF00907.22 VDK75767.1 - 1.7e-49 168.6 0.1 2.1e-49 168.3 0.1 1.1 1 0 0 1 1 1 1 T-box Glyco_hydro_36C PF16874.5 VDK75767.1 - 0.017 15.6 0.0 0.042 14.3 0.0 1.6 1 1 0 1 1 1 0 Glycosyl hydrolase family 36 C-terminal domain EAP30 PF04157.16 VDK75769.1 - 4e-69 232.5 0.7 4.6e-69 232.3 0.7 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family CCCAP PF15964.5 VDK75769.1 - 0.04 12.2 0.2 0.062 11.6 0.2 1.2 1 0 0 1 1 1 0 Centrosomal colon cancer autoantigen protein family Spc42p PF11544.8 VDK75769.1 - 0.089 12.8 0.2 0.2 11.7 0.2 1.6 1 0 0 1 1 1 0 Spindle pole body component Spc42p ETF_QO PF05187.13 VDK75770.1 - 3.1e-44 149.4 0.1 2.4e-43 146.5 0.1 2.1 2 0 0 2 2 2 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 VDK75770.1 - 6.6e-07 28.7 0.2 0.00042 19.5 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 VDK75770.1 - 1.3e-06 27.8 0.0 9.9e-05 21.7 0.1 2.2 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 VDK75770.1 - 5.8e-06 26.4 0.1 0.00032 20.9 0.0 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 VDK75770.1 - 1.2e-05 25.0 0.3 0.00078 19.1 0.2 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 VDK75770.1 - 0.00017 20.8 0.1 0.00059 19.0 0.1 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 VDK75770.1 - 0.00059 19.2 0.0 0.00088 18.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 VDK75770.1 - 0.0017 17.7 0.2 0.0031 16.8 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 VDK75770.1 - 0.0056 15.4 0.1 0.0089 14.8 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 VDK75770.1 - 0.0083 16.7 0.2 2.1 9.0 0.2 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 VDK75770.1 - 0.013 15.5 0.1 0.029 14.4 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 VDK75770.1 - 0.042 13.1 0.0 0.075 12.3 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain K_oxygenase PF13434.6 VDK75770.1 - 0.049 12.8 0.0 0.079 12.1 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 VDK75770.1 - 0.071 11.9 0.3 0.37 9.6 0.2 2.2 3 0 0 3 3 3 0 Tryptophan halogenase Fer4_9 PF13187.6 VDK75770.1 - 0.12 12.6 4.2 0.49 10.6 2.0 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_7 PF12838.7 VDK75770.1 - 0.15 12.6 5.6 0.2 12.2 2.9 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Vinculin PF01044.19 VDK75776.1 - 0.77 7.9 6.2 0.72 8.0 6.2 1.1 1 0 0 1 1 1 0 Vinculin family HD_4 PF13328.6 VDK75777.1 - 2.9e-23 82.3 0.4 3.9e-23 81.9 0.4 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.22 VDK75777.1 - 1e-05 25.7 0.7 2.8e-05 24.3 0.2 1.9 2 1 0 2 2 2 1 HD domain ANAPC8 PF04049.13 VDK75777.1 - 0.052 13.6 0.0 0.068 13.2 0.0 1.2 1 0 0 1 1 1 0 Anaphase promoting complex subunit 8 / Cdc23 Ferrochelatase PF00762.19 VDK75778.1 - 9.3e-100 333.8 0.0 1.1e-99 333.5 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 VDK75778.1 - 8.6e-09 35.7 0.0 0.0011 19.3 0.0 2.3 2 0 0 2 2 2 2 CbiX MLANA PF14991.6 VDK75779.1 - 0.15 12.3 0.3 0.22 11.8 0.3 1.2 1 0 0 1 1 1 0 Protein melan-A ATP-synt_F6 PF05511.11 VDK75781.1 - 8e-10 39.0 0.8 5.4e-09 36.4 0.0 2.1 2 0 0 2 2 2 1 Mitochondrial ATP synthase coupling factor 6 ATP_sub_h PF10775.9 VDK75781.1 - 0.017 15.1 2.5 0.1 12.6 0.0 3.0 3 1 1 4 4 4 0 ATP synthase complex subunit h DEAD PF00270.29 VDK75782.1 - 4e-45 153.7 0.0 9.6e-45 152.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK75782.1 - 3.8e-23 81.9 0.0 2.4e-22 79.4 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 VDK75782.1 - 3.7e-15 55.9 0.0 8.7e-15 54.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 VDK75782.1 - 1.8e-07 31.3 0.0 1.2e-06 28.6 0.0 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 VDK75782.1 - 0.0072 15.7 4.7 0.35 10.2 0.0 2.5 2 0 0 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 VDK75782.1 - 0.58 10.4 2.2 0.88 9.8 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF4519 PF15012.6 VDK75782.1 - 0.64 10.2 9.1 0.39 10.9 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) UTP15_C PF09384.10 VDK75783.1 - 4.9e-32 110.6 0.5 7.7e-32 110.0 0.5 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 VDK75783.1 - 1.1e-17 64.1 7.6 0.0038 18.0 0.0 6.3 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK75783.1 - 1.4e-08 34.9 0.0 0.0095 16.2 0.0 4.4 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Mdv1 PF11542.8 VDK75783.1 - 0.1 12.6 0.3 0.5 10.4 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial division protein 1 DUF327 PF03885.13 VDK75783.1 - 0.12 12.4 0.4 0.21 11.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF327) Phage_pRha PF09669.10 VDK75783.1 - 0.13 12.9 0.1 0.76 10.4 0.1 2.2 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) HPS3_N PF14761.6 VDK75783.1 - 0.15 11.6 0.0 9.4 5.7 0.0 2.5 2 1 0 2 2 2 0 Hermansky-Pudlak syndrome 3 HLH PF00010.26 VDK75784.1 - 2.2e-09 37.1 0.3 3.5e-09 36.5 0.3 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Hist_deacetyl PF00850.19 VDK75786.1 - 2.1e-81 273.8 0.3 2.6e-81 273.4 0.3 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Pex19 PF04614.12 VDK75788.1 - 3.5e-37 128.5 12.8 4.4e-37 128.2 12.8 1.1 1 0 0 1 1 1 1 Pex19 protein family MIF4G_like_2 PF09090.11 VDK75788.1 - 0.11 12.0 6.8 0.034 13.6 2.5 2.0 2 0 0 2 2 2 0 MIF4G like RB_A PF01858.17 VDK75788.1 - 0.17 11.7 5.9 0.056 13.3 2.1 1.9 1 1 0 2 2 2 0 Retinoblastoma-associated protein A domain DUF3037 PF11236.8 VDK75788.1 - 0.37 11.2 3.4 40 4.7 0.8 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3037) MIEAP PF16026.5 VDK75788.1 - 0.45 10.7 6.1 0.44 10.7 4.6 1.7 1 1 0 1 1 1 0 Mitochondria-eating protein IZUMO PF15005.6 VDK75788.1 - 1.3 9.5 4.7 0.96 10.0 1.0 2.4 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated DUF5388 PF17363.2 VDK75788.1 - 1.4 9.1 6.7 4.7 7.5 0.4 3.6 3 1 0 3 3 3 0 Family of unknown function (DUF5388) TetR_C_19 PF17924.1 VDK75788.1 - 2.9 8.5 10.2 0.23 12.1 4.2 2.2 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF4803 PF16061.5 VDK75788.1 - 3.1 7.2 6.5 1.5 8.2 0.5 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4803) DUF4363 PF14276.6 VDK75788.1 - 5.4 7.2 9.0 4 7.6 0.2 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4363) Spt5-NGN PF03439.13 VDK75789.1 - 1.1e-24 86.1 0.4 4.8e-24 84.1 0.1 2.1 2 0 0 2 2 2 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 VDK75789.1 - 5.6e-18 64.2 21.9 3.5e-07 30.0 0.3 6.7 7 0 0 7 7 7 5 KOW motif CTD PF12815.7 VDK75789.1 - 4.2e-13 49.7 12.1 4.2e-13 49.7 12.1 2.5 3 0 0 3 3 3 1 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 VDK75789.1 - 1.8e-11 44.8 14.7 1.8e-11 44.8 14.7 3.2 2 1 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal DUF3912 PF13051.6 VDK75789.1 - 0.0069 16.6 0.4 0.08 13.2 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3912) DUF150_C PF17384.2 VDK75789.1 - 0.1 12.8 1.1 1.2 9.3 0.0 3.1 3 0 0 3 3 3 0 RimP C-terminal SH3 domain MFAP1 PF06991.11 VDK75790.1 - 1e-65 221.6 31.9 1e-65 221.6 31.9 2.3 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing RIO1 PF01163.22 VDK75791.1 - 9.1e-44 149.3 0.0 2.3e-43 148.0 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 VDK75791.1 - 6.4e-29 100.0 0.2 1.8e-28 98.6 0.2 1.8 1 0 0 1 1 1 1 Rio2, N-terminal Pribosyltran PF00156.27 VDK75791.1 - 8.1e-22 77.4 0.0 1.9e-21 76.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain APH PF01636.23 VDK75791.1 - 1.8e-08 34.6 0.0 0.0047 16.9 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 VDK75791.1 - 9.7e-07 28.3 0.1 3.5e-05 23.2 0.1 2.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family UPRTase PF14681.6 VDK75791.1 - 0.029 13.8 0.1 0.21 11.0 0.0 2.1 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase Pkinase_fungal PF17667.1 VDK75791.1 - 0.21 10.3 0.0 0.21 10.3 0.0 2.2 1 1 1 2 2 2 0 Fungal protein kinase Muted PF14942.6 VDK75792.1 - 5.3e-06 26.8 2.9 6.7e-06 26.5 2.9 1.1 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein DUF2498 PF10692.9 VDK75792.1 - 0.042 13.7 0.0 0.076 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) LPD22 PF18834.1 VDK75792.1 - 0.073 13.3 0.2 0.16 12.2 0.0 1.6 2 0 0 2 2 2 0 Large polyvalent protein associated domain 22 NGP1NT PF08153.12 VDK75793.1 - 1.8e-50 170.4 0.7 3.5e-50 169.5 0.7 1.5 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 VDK75793.1 - 3.9e-16 59.1 0.1 2.7e-13 50.0 0.0 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDK75793.1 - 6.8e-06 26.1 0.0 1.8e-05 24.7 0.0 1.8 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 VDK75793.1 - 9.1e-06 25.3 0.1 0.0021 17.6 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Arf PF00025.21 VDK75793.1 - 0.00081 18.9 0.0 0.3 10.5 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK75793.1 - 0.01 15.4 0.1 0.57 9.7 0.1 2.8 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain CsgF PF10614.9 VDK75794.1 - 0.94 9.7 5.2 0.42 10.8 0.5 2.4 1 1 1 2 2 2 0 Type VIII secretion system (T8SS), CsgF protein BTB_2 PF02214.22 VDK75807.1 - 1.6e-19 70.0 0.1 2.7e-19 69.3 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans PF00520.31 VDK75807.1 - 9.9e-16 57.7 5.0 1.4e-15 57.2 5.0 1.2 1 0 0 1 1 1 1 Ion transport protein ThiF PF00899.21 VDK75809.1 - 2.5e-22 79.4 0.0 4e-22 78.8 0.0 1.3 1 1 0 1 1 1 1 ThiF family Neur_chan_LBD PF02931.23 VDK75810.1 - 6.2e-24 84.6 0.5 6.1e-11 42.2 0.0 2.5 2 1 1 3 3 3 2 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK75810.1 - 1.1e-21 78.0 7.1 6.9e-17 62.3 1.2 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Sec20 PF03908.13 VDK75812.1 - 0.068 13.1 0.2 0.068 13.1 0.2 2.3 2 1 1 3 3 3 0 Sec20 DUF501 PF04417.12 VDK75819.1 - 0.00014 21.6 0.4 0.00031 20.6 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF501) PH PF00169.29 VDK75822.1 - 1.4e-09 38.4 1.2 2.7e-09 37.5 1.2 1.5 1 0 0 1 1 1 1 PH domain RA PF00788.23 VDK75822.1 - 0.0039 17.8 0.0 0.012 16.2 0.0 1.9 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_11 PF15413.6 VDK75822.1 - 0.031 14.7 1.8 0.061 13.8 1.8 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Caskin-Pro-rich PF16907.5 VDK75822.1 - 0.042 14.4 1.1 0.042 14.4 1.1 3.1 3 0 0 3 3 3 0 Proline rich region of Caskin proteins SmpB PF01668.18 VDK75832.1 - 0.16 11.8 2.1 0.29 11.0 2.1 1.4 1 0 0 1 1 1 0 SmpB protein Glyco_hydro_35 PF01301.19 VDK75833.1 - 2.2e-92 310.1 2.7 8.4e-72 242.5 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 VDK75833.1 - 2.4e-07 31.3 1.2 6.8e-07 29.9 0.0 2.3 3 0 0 3 3 3 1 Beta-galactosidase jelly roll domain Glyco_hydro_42 PF02449.15 VDK75833.1 - 0.01 15.2 0.2 0.24 10.7 0.1 2.6 1 1 1 2 2 2 0 Beta-galactosidase SNARE_assoc PF09335.11 VDK75834.1 - 3.2e-15 56.7 10.0 3.2e-15 56.7 10.0 2.2 3 0 0 3 3 3 1 SNARE associated Golgi protein Keratin_assoc PF09775.9 VDK75834.1 - 0.15 11.8 4.9 1.1 8.9 1.0 2.6 2 0 0 2 2 2 0 Keratinocyte-associated protein 2 DUF4658 PF15555.6 VDK75834.1 - 1.8 8.7 2.9 3.4 7.8 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4658) SIX1_SD PF16878.5 VDK75836.1 - 7.3e-34 116.6 2.7 1.3e-33 115.8 2.7 1.4 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 VDK75836.1 - 1.1e-10 41.1 1.3 1.1e-10 41.1 1.3 2.9 2 1 1 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 VDK75836.1 - 2.1e-08 33.9 1.7 3.8e-08 33.1 1.7 1.4 1 0 0 1 1 1 1 Homeobox KN domain WRW PF10206.9 VDK75836.1 - 0.011 16.0 3.7 1 9.8 0.0 2.5 2 0 0 2 2 2 0 Mitochondrial F1F0-ATP synthase, subunit f Peptidase_C1 PF00112.23 VDK75837.1 - 4.1e-70 236.3 2.4 4.1e-70 236.3 2.4 1.5 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 VDK75837.1 - 1.9e-07 31.4 0.3 4.9e-07 30.1 0.3 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 VDK75837.1 - 0.0011 17.8 1.4 0.027 13.3 0.5 2.4 2 1 0 2 2 2 2 Peptidase C1-like family Ubiq_cyt_C_chap PF03981.12 VDK75837.1 - 0.0065 16.6 0.4 0.011 15.8 0.4 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone YIF1 PF03878.15 VDK75838.1 - 1e-74 251.1 11.3 1.2e-74 250.8 11.3 1.1 1 0 0 1 1 1 1 YIF1 DUF4271 PF14093.6 VDK75838.1 - 5.6 6.8 21.5 2.8 7.8 19.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) Acyltransferase PF01553.21 VDK75840.1 - 9e-32 109.5 0.1 1.9e-31 108.5 0.1 1.5 2 0 0 2 2 2 1 Acyltransferase Reeler PF02014.16 VDK75841.1 - 2.5e-21 76.8 0.9 3.1e-21 76.5 0.9 1.1 1 0 0 1 1 1 1 Reeler domain PKcGMP_CC PF16808.5 VDK75845.1 - 0.35 10.7 10.2 12 5.8 0.2 4.4 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Xylo_C PF12529.8 VDK75845.1 - 9.6 5.8 9.1 0.44 10.1 0.4 2.5 2 0 0 2 2 2 0 Xylosyltransferase C terminal KH_1 PF00013.29 VDK75874.1 - 7.6e-44 147.4 12.5 8.4e-18 64.0 1.4 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 VDK75874.1 - 3.2e-19 68.5 7.4 1.2e-07 31.5 0.4 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 VDK75874.1 - 1.1e-09 38.2 5.4 0.0058 16.7 0.4 3.5 3 1 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 VDK75874.1 - 0.0037 17.1 12.6 0.17 11.8 0.1 4.1 3 1 1 4 4 4 2 KH domain KRBA1 PF15287.6 VDK75874.1 - 0.13 12.0 0.4 3.2 7.5 0.1 2.3 2 0 0 2 2 2 0 KRBA1 family repeat Med8 PF10232.9 VDK75874.1 - 0.16 11.5 0.1 0.23 11.0 0.1 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 dsrm PF00035.26 VDK75876.1 - 9.2e-37 125.6 7.1 4.2e-10 40.2 0.2 5.4 5 1 1 6 6 6 4 Double-stranded RNA binding motif Staufen_C PF16482.5 VDK75876.1 - 5.5e-08 33.0 1.9 0.013 15.6 0.2 4.9 3 1 0 3 3 3 2 Staufen C-terminal domain DND1_DSRM PF14709.7 VDK75876.1 - 4.3e-05 23.7 4.2 1.3 9.3 0.0 4.9 4 1 0 4 4 4 2 double strand RNA binding domain from DEAD END PROTEIN 1 HORMA PF02301.18 VDK75876.1 - 0.015 14.9 0.2 4.4 6.8 0.2 2.7 2 0 0 2 2 2 0 HORMA domain Octopine_DH PF02317.17 VDK75876.1 - 0.091 12.9 0.0 0.39 10.8 0.0 2.1 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain LPP20 PF02169.16 VDK75876.1 - 0.73 10.2 8.5 3.1 8.2 0.0 4.7 5 0 0 5 5 5 0 LPP20 lipoprotein LIN37 PF15306.6 VDK75876.1 - 1.7 8.9 4.9 14 5.9 0.2 2.8 2 0 0 2 2 2 0 LIN37 Aida_C2 PF14186.6 VDK75878.1 - 0.078 12.6 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Cytoskeletal adhesion Shisa PF13908.6 VDK75879.1 - 6 7.1 10.2 0.68 10.2 0.3 3.8 4 1 1 5 5 5 0 Wnt and FGF inhibitory regulator TRAPPC9-Trs120 PF08626.11 VDK75880.1 - 2.7e-26 91.4 0.0 1.6e-14 52.3 0.0 4.3 4 2 0 4 4 4 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TRAPPC-Trs85 PF12739.7 VDK75880.1 - 0.094 11.7 0.4 0.22 10.5 0.4 1.5 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit PKD PF00801.20 VDK75881.1 - 3e-12 46.2 0.3 0.006 16.4 0.0 5.1 5 0 0 5 5 5 3 PKD domain HemY_N PF07219.13 VDK75881.1 - 0.015 15.5 0.2 0.033 14.4 0.2 1.5 1 0 0 1 1 1 0 HemY protein N-terminus EGF_2 PF07974.13 VDK75881.1 - 0.02 15.3 7.1 0.02 15.3 7.1 2.8 2 0 0 2 2 2 0 EGF-like domain Toxin_23 PF08093.11 VDK75883.1 - 6.9 6.9 6.2 6.5 7.0 1.7 2.4 2 0 0 2 2 2 0 Magi 5 toxic peptide family Pkinase PF00069.25 VDK75887.1 - 1.7e-14 53.9 0.0 2.7e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK75887.1 - 7.8e-06 25.4 0.0 1.1e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK75887.1 - 0.0033 17.4 0.1 0.02 14.8 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Tropomyosin PF00261.20 VDK75887.1 - 1.4 8.2 6.0 0.45 9.9 1.6 2.0 2 0 0 2 2 2 0 Tropomyosin TSP_1 PF00090.19 VDK75890.1 - 0.38 11.0 13.5 0.2 11.9 10.4 2.3 2 1 0 2 2 2 0 Thrombospondin type 1 domain Homeodomain PF00046.29 VDK75892.1 - 7.4e-10 38.5 5.4 0.0001 22.0 0.3 3.0 2 1 0 2 2 2 2 Homeodomain ULD PF16534.5 VDK75892.1 - 8.8e-09 35.4 0.7 1.7e-08 34.4 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin-like oligomerisation domain of SATB Homeobox_KN PF05920.11 VDK75892.1 - 0.0033 17.3 1.5 0.074 13.0 0.3 3.0 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 VDK75892.1 - 0.027 13.9 0.0 1.6 8.2 0.0 2.5 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez AAA_14 PF13173.6 VDK75892.1 - 0.35 10.9 2.4 1.9 8.5 0.3 2.8 2 1 1 3 3 3 0 AAA domain ULD PF16534.5 VDK75893.1 - 7.9e-06 25.9 0.0 1e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like oligomerisation domain of SATB Elong_Iki1 PF10483.9 VDK75916.1 - 2e-09 37.4 3.0 7.4e-05 22.4 0.0 2.1 1 1 1 2 2 2 2 Elongator subunit Iki1 DUF835 PF05763.12 VDK75916.1 - 0.00062 19.5 0.5 0.0012 18.6 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF835) DUF659 PF04937.15 VDK75916.1 - 0.064 13.1 1.0 1.6 8.6 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF 659) Smg4_UPF3 PF03467.15 VDK75916.1 - 0.099 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Smg-4/UPF3 family ArfGap PF01412.18 VDK75918.1 - 5.2e-35 120.0 0.0 1.3e-34 118.8 0.0 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 VDK75918.1 - 1.7e-34 119.6 1.8 1.7e-34 119.6 1.8 1.7 2 0 0 2 2 2 1 BAR domain of APPL family Ank_2 PF12796.7 VDK75918.1 - 8e-19 68.0 10.8 8.7e-11 42.3 1.3 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) PH PF00169.29 VDK75918.1 - 1.9e-16 60.5 0.1 4.5e-16 59.3 0.1 1.7 1 0 0 1 1 1 1 PH domain Ank_5 PF13857.6 VDK75918.1 - 1.8e-12 47.2 0.6 3.3e-07 30.4 0.5 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 VDK75918.1 - 6.5e-11 42.5 1.7 5.7e-05 23.6 0.0 4.5 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 VDK75918.1 - 3.5e-09 36.7 3.3 0.0044 17.4 0.1 4.0 2 1 1 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 VDK75918.1 - 8e-09 35.1 0.9 0.028 15.0 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat BAR PF03114.18 VDK75918.1 - 0.016 14.9 1.7 0.071 12.7 0.1 2.4 3 0 0 3 3 3 0 BAR domain PH_11 PF15413.6 VDK75918.1 - 0.034 14.6 3.2 1.1 9.7 1.7 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain PH_8 PF15409.6 VDK75918.1 - 0.036 14.3 1.6 3 8.2 0.1 3.2 3 1 0 3 3 3 0 Pleckstrin homology domain Copine PF07002.16 VDK75920.1 - 1.3e-58 198.0 0.0 2.6e-58 197.1 0.0 1.4 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 VDK75920.1 - 1.5e-06 28.5 0.0 4.4e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 vWA found in TerF C terminus Pyocin_S PF06958.12 VDK75920.1 - 0.019 15.5 0.7 0.049 14.2 0.7 1.7 1 0 0 1 1 1 0 S-type Pyocin VWA PF00092.28 VDK75920.1 - 0.057 13.7 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain DIRP PF06584.13 VDK75920.1 - 0.19 11.9 4.0 0.2 11.8 1.2 2.5 2 1 1 3 3 3 0 DIRP zf-RING_2 PF13639.6 VDK75921.1 - 2.3e-11 43.9 9.5 4.3e-11 43.0 9.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 VDK75921.1 - 1.6e-08 34.1 5.9 1.6e-08 34.1 5.9 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 VDK75921.1 - 2.5e-07 30.6 6.7 6e-07 29.4 6.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDK75921.1 - 2.2e-06 27.4 9.4 4.4e-06 26.4 9.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK75921.1 - 1.6e-05 24.7 5.1 2.7e-05 23.9 5.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK75921.1 - 1.6e-05 24.7 7.4 2.9e-05 23.9 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK75921.1 - 0.00065 19.6 5.6 0.00065 19.6 5.6 1.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 VDK75921.1 - 0.0048 17.2 12.2 0.0048 17.2 12.2 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain FANCL_C PF11793.8 VDK75921.1 - 0.0095 16.1 8.5 0.13 12.5 8.5 2.4 1 1 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 VDK75921.1 - 0.08 13.0 7.6 0.39 10.8 7.8 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 VDK75921.1 - 0.13 12.1 10.2 17 5.3 11.0 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 VDK75921.1 - 1.8 8.2 11.3 0.056 13.1 5.4 1.6 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RabGAP-TBC PF00566.18 VDK75922.1 - 2.9e-31 108.8 12.8 4.6e-29 101.6 12.8 2.3 1 1 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 VDK75922.1 - 7.7e-17 61.3 0.0 2.1e-16 59.9 0.0 1.7 1 1 0 1 1 1 1 Rab-binding domain (RBD) CLP_protease PF00574.23 VDK75923.1 - 6.2e-76 254.4 0.4 7.5e-76 254.1 0.4 1.0 1 0 0 1 1 1 1 Clp protease ATP-synt_F PF01990.17 VDK75925.1 - 4.3e-32 110.3 0.2 4.9e-32 110.1 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit TPR_1 PF00515.28 VDK75926.1 - 4.7e-22 76.8 12.2 5.3e-07 29.2 0.2 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 VDK75926.1 - 4.8e-21 73.1 12.3 6.1e-05 22.8 0.1 5.9 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 VDK75926.1 - 8e-18 63.8 14.6 3.1e-05 23.6 0.1 5.4 3 2 2 5 5 5 5 TPR repeat TPR_19 PF14559.6 VDK75926.1 - 6.7e-17 61.8 10.2 1.2e-05 25.8 0.1 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 VDK75926.1 - 1.3e-14 53.1 11.6 0.003 17.6 0.1 6.1 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 VDK75926.1 - 1.6e-13 50.2 5.3 0.036 14.9 0.0 5.9 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 VDK75926.1 - 1.8e-11 44.5 6.0 0.00042 20.9 0.3 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 VDK75926.1 - 5.7e-11 42.0 11.2 0.0066 16.8 0.3 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK75926.1 - 5.7e-09 36.1 6.1 2.7e-06 27.6 1.3 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 VDK75926.1 - 6.5e-08 32.1 8.3 0.00041 19.7 0.4 3.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 VDK75926.1 - 9.8e-06 25.3 8.0 0.0039 17.1 0.1 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK75926.1 - 2e-05 24.7 9.4 0.073 13.3 1.4 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 VDK75926.1 - 2.2e-05 24.7 4.7 0.33 11.3 0.0 4.0 2 2 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 VDK75926.1 - 0.00092 19.3 1.1 0.52 10.5 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 VDK75926.1 - 0.0012 18.6 10.7 0.052 13.4 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat RPN7 PF10602.9 VDK75926.1 - 0.017 14.8 0.2 0.077 12.7 0.0 2.2 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_6 PF13174.6 VDK75926.1 - 0.022 15.4 4.0 11 6.9 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 VDK75926.1 - 0.77 9.9 3.3 12 6.1 0.0 3.4 3 1 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 VDK75926.1 - 4 7.6 9.0 2 8.6 0.1 4.2 4 1 0 4 4 4 0 MIT (microtubule interacting and transport) domain RRM_1 PF00076.22 VDK75929.1 - 2e-54 181.3 0.0 7.7e-20 70.5 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK75929.1 - 1.3e-07 31.6 0.1 0.41 10.8 0.0 3.9 3 1 0 3 3 3 3 RNA recognition motif RNA_bind PF08675.11 VDK75929.1 - 6.1e-06 26.2 0.0 2.1 8.4 0.0 3.8 3 1 0 3 3 3 3 RNA binding domain RRM_5 PF13893.6 VDK75929.1 - 4.4e-05 23.1 0.0 0.35 10.5 0.1 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 VDK75929.1 - 0.0065 16.7 1.9 2.1 8.6 0.2 3.8 3 2 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 VDK75929.1 - 0.014 15.4 0.0 0.61 10.1 0.0 2.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 VDK75929.1 - 0.088 12.9 1.9 0.61 10.2 0.1 3.0 4 0 0 4 4 4 0 RNA binding motif DUF2304 PF10066.9 VDK75929.1 - 0.35 11.1 2.8 19 5.5 0.4 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) AA_permease_2 PF13520.6 VDK75930.1 - 3.3e-32 111.9 38.3 3.3e-32 111.9 38.3 3.1 1 1 2 3 3 3 2 Amino acid permease AA_permease PF00324.21 VDK75930.1 - 2.5e-22 79.1 44.9 2.5e-22 79.1 44.9 3.0 2 2 1 3 3 3 1 Amino acid permease AA_permease_C PF13906.6 VDK75930.1 - 1.1e-21 76.7 8.4 1.1e-21 76.7 8.4 4.7 6 0 0 6 6 6 1 C-terminus of AA_permease DUF3361 PF11841.8 VDK75931.1 - 0.0023 17.9 4.9 0.34 10.8 0.0 4.3 1 1 0 3 3 3 1 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 VDK75931.1 - 0.017 15.2 1.9 7.4 6.7 0.0 3.6 4 0 0 4 4 4 0 V-ATPase subunit H HEAT PF02985.22 VDK75931.1 - 0.091 13.1 0.3 11 6.6 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat RTP1_C1 PF10363.9 VDK75931.1 - 0.26 11.5 2.0 22 5.2 0.0 3.5 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 VDK75931.1 - 0.7 9.9 3.8 18 5.4 0.2 3.5 3 3 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Ras PF00071.22 VDK75932.1 - 3.5e-06 26.7 0.0 5.2e-06 26.1 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 VDK75932.1 - 0.0083 16.3 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DEP PF00610.21 VDK75933.1 - 2.7e-16 59.4 0.1 7.8e-16 57.9 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ PF00595.24 VDK75933.1 - 4.8e-13 49.3 0.1 9.7e-13 48.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain DIX PF00778.17 VDK75933.1 - 1.6e-09 37.4 2.5 9.1e-09 35.0 0.4 2.7 2 1 0 2 2 2 1 DIX domain PDZ_6 PF17820.1 VDK75933.1 - 1.1e-05 25.2 0.1 2.7e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK75933.1 - 0.043 14.2 0.1 0.11 12.8 0.1 1.8 1 0 0 1 1 1 0 PDZ domain Neur_chan_LBD PF02931.23 VDK75934.1 - 2.6e-34 118.6 0.4 5.9e-34 117.4 0.4 1.6 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK75934.1 - 5.6e-19 69.2 0.1 1.2e-18 68.1 0.1 1.6 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_L30_N PF08079.12 VDK75934.1 - 1.8 8.8 6.0 3.9 7.8 6.0 1.5 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain ETF PF01012.21 VDK75969.1 - 1.8e-36 125.7 0.4 3.1e-36 124.9 0.4 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 VDK75969.1 - 4.6e-36 122.7 1.7 4.6e-36 122.7 1.7 1.8 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain RRM_1 PF00076.22 VDK75970.1 - 7.7e-10 38.5 0.1 2e-07 30.7 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CoaE PF01121.20 VDK75973.1 - 2.9e-39 134.6 0.1 5e-39 133.8 0.1 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase CTP_transf_like PF01467.26 VDK75973.1 - 8.5e-08 32.5 0.1 5.5e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 Cytidylyltransferase-like FAD_syn PF06574.12 VDK75973.1 - 0.0026 17.7 0.0 0.0061 16.5 0.0 1.6 1 0 0 1 1 1 1 FAD synthetase AAA_18 PF13238.6 VDK75973.1 - 0.0077 16.8 0.4 0.099 13.2 0.6 2.6 2 1 0 2 2 2 1 AAA domain SH2 PF00017.24 VDK75974.1 - 1.6e-10 40.9 0.0 4.6e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 SH2 domain tRNA-synt_2c PF01411.19 VDK75975.1 - 1.9e-217 723.2 0.0 2.6e-217 722.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) DHHA1 PF02272.19 VDK75975.1 - 1.7e-16 60.9 6.0 4e-16 59.7 6.0 1.7 1 0 0 1 1 1 1 DHHA1 domain tRNA_SAD PF07973.14 VDK75975.1 - 5.9e-16 58.3 0.3 2e-15 56.6 0.3 2.0 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain BshC PF10079.9 VDK75975.1 - 0.25 10.0 3.5 0.36 9.5 3.5 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC TBP PF00352.21 VDK75976.1 - 9e-40 134.5 0.0 6.4e-20 70.9 0.0 2.3 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) Cript PF10235.9 VDK75977.1 - 8.4e-27 93.6 6.5 9.7e-27 93.4 6.5 1.0 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DUF2039 PF10217.9 VDK75977.1 - 0.003 17.9 9.2 0.0041 17.4 9.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) Rhodanese_C PF12368.8 VDK75977.1 - 0.037 14.4 4.9 0.051 14.0 4.9 1.2 1 0 0 1 1 1 0 Rhodanase C-terminal PolC_DP2 PF03833.13 VDK75977.1 - 0.043 11.7 2.7 0.049 11.5 2.7 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 VDK75977.1 - 0.43 10.7 8.2 5.4 7.1 8.2 2.2 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 VDK75977.1 - 0.67 9.8 4.3 4.2 7.2 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain C1_2 PF03107.16 VDK75977.1 - 0.82 10.0 8.1 1.7 9.0 3.1 2.2 1 1 1 2 2 2 0 C1 domain Cu2_monoox_C PF03712.15 VDK75978.1 - 1.2e-31 109.4 0.0 1.8e-31 108.8 0.0 1.2 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cu2_monooxygen PF01082.20 VDK75978.1 - 3e-16 59.8 0.0 5.2e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Copper type II ascorbate-dependent monooxygenase, N-terminal domain NHL PF01436.21 VDK75979.1 - 2.1e-26 90.6 1.6 3.7e-07 29.9 0.1 4.6 4 0 0 4 4 4 4 NHL repeat SGL PF08450.12 VDK75979.1 - 7.2e-06 25.8 0.1 0.14 11.7 0.0 3.3 2 2 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 VDK75979.1 - 0.00063 19.1 0.1 0.58 9.4 0.1 2.4 1 1 0 2 2 2 2 Lactonase, 7-bladed beta-propeller DUF5128 PF17170.4 VDK75979.1 - 0.0046 16.1 0.0 1.1 8.4 0.0 2.4 2 0 0 2 2 2 2 6-bladed beta-propeller Kelch_6 PF13964.6 VDK75979.1 - 0.028 14.7 0.3 0.77 10.1 0.1 3.0 3 0 0 3 3 3 0 Kelch motif Arylesterase PF01731.20 VDK75979.1 - 0.049 13.8 0.0 6 7.1 0.0 3.0 3 0 0 3 3 3 0 Arylesterase PD40 PF07676.12 VDK75979.1 - 0.06 13.3 0.0 1.9 8.5 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Ubiq-assoc PF09145.10 VDK75979.1 - 0.17 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-associated SNF2_N PF00176.23 VDK75980.1 - 5.1e-63 212.9 1.0 1.2e-62 211.7 1.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain BRK PF07533.16 VDK75980.1 - 1.2e-30 104.9 0.0 7.2e-15 54.3 0.0 2.7 2 0 0 2 2 2 2 BRK domain Helicase_C PF00271.31 VDK75980.1 - 4.9e-19 68.7 0.2 3.3e-18 66.0 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 VDK75980.1 - 1.3e-16 60.2 4.5 7.2e-09 35.4 1.3 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain HDA2-3 PF11496.8 VDK75980.1 - 2.8e-07 30.0 0.8 1.7e-06 27.5 0.8 2.3 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 VDK75980.1 - 2.7e-06 27.5 0.2 1.9e-05 24.7 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 VDK75980.1 - 0.0011 19.2 0.6 2.1 8.6 0.0 3.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain MSP1_C PF07462.11 VDK75981.1 - 0.15 10.7 2.4 0.2 10.3 2.4 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus TMEM189_B_dmain PF10520.9 VDK75982.1 - 5e-64 215.6 7.2 6.5e-64 215.2 7.2 1.1 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain RhoGAP PF00620.27 VDK75983.1 - 1.5e-28 99.5 0.0 2.9e-28 98.6 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain HSP70 PF00012.20 VDK76001.1 - 7.8e-84 282.0 11.6 7.8e-84 282.0 11.6 3.1 2 1 1 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 VDK76001.1 - 0.0023 16.8 1.6 0.072 11.9 0.2 2.5 2 0 0 2 2 2 2 MreB/Mbl protein Ribosomal_S5 PF00333.20 VDK76003.1 - 4.5e-30 103.4 0.8 9.5e-30 102.4 0.8 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 VDK76003.1 - 8.1e-25 86.1 0.0 1.4e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 VDK76003.1 - 8.8 7.0 21.2 20 5.8 21.2 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 O-FucT PF10250.9 VDK76004.1 - 1.1e-37 130.5 0.1 1.4e-37 130.2 0.1 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Glyco_transf_11 PF01531.16 VDK76004.1 - 0.015 14.6 0.2 0.019 14.2 0.2 1.2 1 0 0 1 1 1 0 Glycosyl transferase family 11 O-FucT PF10250.9 VDK76006.1 - 3.8e-22 79.4 0.1 4.9e-22 79.1 0.1 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Sec7 PF01369.20 VDK76008.1 - 2.2e-65 219.8 0.0 3.1e-65 219.3 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 VDK76008.1 - 1.8e-23 83.0 0.3 3.6e-23 82.1 0.3 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 VDK76008.1 - 0.00043 20.7 0.1 0.00087 19.7 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 VDK76008.1 - 0.14 12.3 0.1 0.62 10.2 0.1 2.0 1 1 0 1 1 1 0 PH domain Sec7_N PF12783.7 VDK76009.1 - 6.1e-05 23.0 0.4 0.089 12.7 0.1 3.3 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Arm PF00514.23 VDK76009.1 - 0.00043 20.2 0.0 0.092 12.8 0.0 3.1 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat DUF5578 PF17741.1 VDK76009.1 - 0.009 15.5 1.5 0.11 11.9 0.0 2.6 2 1 1 3 3 3 2 Family of unknown function (DUF5578) Tti2 PF10521.9 VDK76009.1 - 0.29 10.6 4.4 1.4 8.3 0.1 3.3 2 1 2 4 4 4 0 Tti2 family Synaptobrevin PF00957.21 VDK76011.1 - 1e-23 82.9 5.9 1.2e-23 82.7 5.9 1.0 1 0 0 1 1 1 1 Synaptobrevin DUF2721 PF11026.8 VDK76011.1 - 0.00015 21.7 0.7 0.00017 21.5 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2721) Prominin PF05478.11 VDK76011.1 - 0.0014 16.7 0.7 0.0017 16.5 0.7 1.1 1 0 0 1 1 1 1 Prominin EVI2A PF05399.11 VDK76011.1 - 0.0075 15.9 0.2 0.0084 15.7 0.2 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) NEXCaM_BD PF16644.5 VDK76011.1 - 0.016 15.5 0.5 0.021 15.0 0.5 1.3 1 0 0 1 1 1 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin TMEM214 PF10151.9 VDK76011.1 - 0.022 13.3 0.2 0.022 13.2 0.2 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Sigma_reg_N PF13800.6 VDK76011.1 - 0.022 15.0 1.0 0.022 15.0 1.0 1.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal RIFIN PF02009.16 VDK76011.1 - 0.024 14.5 1.1 0.028 14.3 1.1 1.1 1 0 0 1 1 1 0 Rifin SHE3 PF17078.5 VDK76011.1 - 0.037 13.8 0.2 0.044 13.5 0.2 1.0 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Dor1 PF04124.12 VDK76011.1 - 0.047 12.4 0.2 0.056 12.1 0.2 1.1 1 0 0 1 1 1 0 Dor1-like family LAP1C PF05609.12 VDK76011.1 - 0.11 11.6 0.2 0.12 11.5 0.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Wzz PF02706.15 VDK76011.1 - 6.1 7.2 6.6 3 8.2 3.1 1.9 2 0 0 2 2 2 0 Chain length determinant protein B9-C2 PF07162.11 VDK76013.1 - 3.1e-28 99.1 0.0 5.7e-28 98.2 0.0 1.5 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein NinF PF05810.12 VDK76014.1 - 0.12 12.3 0.2 0.2 11.6 0.2 1.5 1 1 0 1 1 1 0 NinF protein bZIP_2 PF07716.15 VDK76015.1 - 1.1e-11 44.6 12.8 1.6e-11 44.1 12.8 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 VDK76015.1 - 1.3e-06 28.3 10.7 1.1e-05 25.4 10.9 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 VDK76015.1 - 0.0097 16.4 7.8 0.016 15.7 7.8 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.18 VDK76015.1 - 0.015 15.5 1.5 0.032 14.5 1.5 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper Mto2_bdg PF12808.7 VDK76015.1 - 1.6 9.1 14.0 22 5.4 14.1 2.2 1 1 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region FYVE PF01363.21 VDK76016.1 - 2.4e-17 62.8 10.1 8.1e-17 61.1 10.1 1.9 1 1 0 1 1 1 1 FYVE zinc finger Rbsn PF11464.8 VDK76016.1 - 1.7e-12 46.9 2.6 1.7e-12 46.9 2.6 2.4 2 0 0 2 2 2 1 Rabenosyn Rab binding domain zf-CRD PF17979.1 VDK76016.1 - 0.024 14.8 3.3 0.07 13.2 3.3 1.8 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions DUF4349 PF14257.6 VDK76016.1 - 0.95 8.9 6.0 0.35 10.3 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) FYVE_2 PF02318.16 VDK76016.1 - 10 6.4 14.8 0.2 11.9 2.1 3.8 4 1 0 4 4 4 0 FYVE-type zinc finger AARP2CN PF08142.12 VDK76018.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 AARP2CN (NUC121) domain CPG4 PF15481.6 VDK76044.1 - 6.6e-12 45.9 4.9 6.6e-12 45.9 4.9 1.8 2 0 0 2 2 2 1 Chondroitin proteoglycan 4 Serpin PF00079.20 VDK76046.1 - 6.7e-10 38.8 0.3 0.00036 20.0 0.0 3.4 2 1 1 3 3 3 3 Serpin (serine protease inhibitor) IBN_N PF03810.19 VDK76048.1 - 0.0035 17.2 0.2 0.012 15.5 0.2 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 VDK76048.1 - 0.0048 17.0 4.0 0.22 11.6 0.0 4.8 5 0 0 5 5 5 1 Exportin 1-like protein DUF5601 PF18151.1 VDK76048.1 - 0.14 12.5 0.6 12 6.4 0.3 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) RasGEF_N_2 PF14663.6 VDK76048.1 - 0.15 12.5 3.4 13 6.3 0.0 3.7 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain MOLO1 PF17175.4 VDK76049.1 - 2.4e-24 85.8 0.2 4.3e-24 84.9 0.2 1.4 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 VDK76049.1 - 2.8e-10 40.4 0.4 1.5e-08 34.9 0.4 2.1 1 1 0 1 1 1 1 TPM domain WBP-1 PF11669.8 VDK76049.1 - 0.014 16.0 0.5 0.014 16.0 0.5 2.6 2 1 0 2 2 2 0 WW domain-binding protein 1 Mucin PF01456.17 VDK76049.1 - 0.016 15.2 2.7 0.37 10.8 0.2 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein bVLRF1 PF18826.1 VDK76049.1 - 0.035 14.0 0.4 0.056 13.3 0.4 1.3 1 0 0 1 1 1 0 bacteroidetes VLRF1 release factor TMEM251 PF15190.6 VDK76049.1 - 0.064 13.2 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 251 Peptidase_S11 PF00768.20 VDK76049.1 - 0.19 11.1 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase FAM163 PF15069.6 VDK76049.1 - 0.52 10.7 8.0 0.52 10.8 2.1 2.3 2 0 0 2 2 2 0 FAM163 family TMEM52 PF14979.6 VDK76049.1 - 0.59 10.0 10.8 0.24 11.3 5.8 2.1 2 0 0 2 2 2 0 Transmembrane 52 Prominin PF05478.11 VDK76049.1 - 9.1 4.1 11.5 16 3.3 11.5 1.3 1 0 0 1 1 1 0 Prominin RGS_DHEX PF18148.1 VDK76050.1 - 9.7e-49 163.6 2.3 2.5e-48 162.3 2.3 1.7 1 0 0 1 1 1 1 Regulator of G-protein signalling DHEX domain RGS PF00615.19 VDK76050.1 - 1.3e-28 99.7 1.1 1.3e-28 99.7 1.1 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 VDK76050.1 - 4e-14 52.4 0.0 1e-13 51.1 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) G-gamma PF00631.22 VDK76050.1 - 7.6e-12 45.1 0.0 2e-11 43.7 0.0 1.7 1 0 0 1 1 1 1 GGL domain CDI PF02234.19 VDK76050.1 - 2.1 8.6 6.2 0.43 10.8 1.8 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor PapC_N PF13954.6 VDK76051.1 - 0.0027 17.7 0.4 0.011 15.8 0.1 2.2 2 0 0 2 2 2 1 PapC N-terminal domain MctB PF11382.8 VDK76051.1 - 0.17 11.6 4.3 7 6.3 0.1 2.9 3 0 0 3 3 3 0 Copper transport outer membrane protein, MctB DUF4790 PF16037.5 VDK76051.1 - 0.29 11.6 2.7 42 4.7 3.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4790) LRR_4 PF12799.7 VDK76051.1 - 6.2 7.4 26.1 9.4 6.8 6.9 5.3 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) SPRY PF00622.28 VDK76053.1 - 5.6e-14 52.3 0.0 9.5e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 SPRY domain fn3 PF00041.21 VDK76053.1 - 4.4e-05 23.8 0.0 8.4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain DUF1041 PF06292.17 VDK76053.1 - 0.038 14.4 0.7 0.11 12.9 0.7 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1041) UPF0004 PF00919.20 VDK76053.1 - 0.15 12.1 0.8 1.4 9.0 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein family UPF0004 Mei5 PF10376.9 VDK76053.1 - 0.5 10.2 5.9 0.81 9.5 5.9 1.3 1 0 0 1 1 1 0 Double-strand recombination repair protein Cadherin PF00028.17 VDK76065.1 - 6.7e-58 193.1 7.0 8.6e-12 45.3 0.2 9.3 9 0 0 9 9 9 7 Cadherin domain DUF4394 PF14339.6 VDK76065.1 - 0.048 13.0 1.8 4.5 6.6 0.1 3.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4394) GLE1 PF07817.13 VDK76067.1 - 4e-06 26.2 0.8 8.9e-06 25.1 0.8 1.6 1 1 0 1 1 1 1 GLE1-like protein Pyr_redox_2 PF07992.14 VDK76069.1 - 5.1e-10 39.1 0.1 0.0058 15.9 0.0 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 VDK76069.1 - 0.024 13.7 0.0 0.36 9.8 0.0 2.4 2 1 1 3 3 3 0 Lycopene cyclase protein EMC3_TMCO1 PF01956.16 VDK76070.1 - 1.2e-37 129.3 0.4 1.4e-37 129.0 0.4 1.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like TssO PF17561.2 VDK76070.1 - 0.0067 16.6 0.1 0.0067 16.6 0.1 1.7 2 0 0 2 2 2 1 Type VI secretion system, TssO 7TM_GPCR_Srx PF10328.9 VDK76070.1 - 0.014 15.1 0.4 2.6 7.6 0.1 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srx SNARE_assoc PF09335.11 VDK76070.1 - 0.024 15.1 0.3 0.096 13.2 0.3 2.0 1 1 0 1 1 1 0 SNARE associated Golgi protein ArsP_1 PF03773.13 VDK76070.1 - 0.025 13.7 0.1 0.041 13.0 0.1 1.2 1 0 0 1 1 1 0 Predicted permease Wzy_C PF04932.15 VDK76070.1 - 0.027 14.1 0.1 0.035 13.7 0.1 1.2 1 0 0 1 1 1 0 O-Antigen ligase Exonuc_VII_L PF02601.15 VDK76070.1 - 0.04 13.5 0.3 0.055 13.0 0.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DivIC PF04977.15 VDK76070.1 - 0.064 13.0 2.4 0.21 11.4 2.5 1.8 1 1 0 1 1 1 0 Septum formation initiator TRAM1 PF08390.11 VDK76070.1 - 0.077 12.7 1.1 0.48 10.1 0.1 2.2 2 0 0 2 2 2 0 TRAM1-like protein DUF3333 PF11812.8 VDK76070.1 - 0.11 12.7 0.3 0.11 12.7 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) CHD5 PF04420.14 VDK76070.1 - 0.21 11.5 2.6 0.41 10.5 2.6 1.5 1 1 0 1 1 1 0 CHD5-like protein CENP-Q PF13094.6 VDK76070.1 - 0.27 11.4 5.9 0.18 12.0 4.6 1.4 2 0 0 2 2 1 0 CENP-Q, a CENPA-CAD centromere complex subunit LapA_dom PF06305.11 VDK76070.1 - 0.32 10.8 0.0 0.32 10.8 0.0 3.2 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain MscS_TM PF12794.7 VDK76070.1 - 0.39 9.5 3.2 0.39 9.5 1.8 1.6 1 1 1 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 DUF819 PF05684.12 VDK76070.1 - 7.4 5.5 6.5 5.7 5.9 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF819) tRNA_synthFbeta PF17759.1 VDK76071.1 - 1.4e-44 152.1 0.0 2e-44 151.6 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 VDK76071.1 - 2.4e-30 104.6 0.4 1.1e-29 102.5 0.1 2.2 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 VDK76071.1 - 7.2e-24 84.4 0.0 1.2e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 VDK76071.1 - 4e-19 68.7 0.2 1.3e-15 57.4 0.1 2.7 2 0 0 2 2 2 2 tRNA synthetase B5 domain CAP_C PF08603.11 VDK76071.1 - 0.075 12.6 3.5 5.3 6.6 0.0 2.3 1 1 1 2 2 2 0 Adenylate cyclase associated (CAP) C terminal DUF2740 PF10872.8 VDK76071.1 - 0.2 11.6 0.5 0.43 10.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2740) Proteasome PF00227.26 VDK76074.1 - 8.4e-44 149.3 0.0 1e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 VDK76074.1 - 1.9e-13 49.8 1.1 2.7e-13 49.3 0.3 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5018 PF16410.5 VDK76074.1 - 0.057 12.1 0.0 1.9 7.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5018) WD40 PF00400.32 VDK76075.1 - 1.1e-57 190.6 24.7 2e-08 34.8 0.1 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK76075.1 - 2.4e-22 79.1 5.6 5.3e-05 23.4 0.0 6.5 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK76075.1 - 2.3e-08 33.4 0.3 0.057 12.4 0.0 5.1 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NLE PF08154.12 VDK76075.1 - 8.6e-08 32.6 0.2 1.7e-07 31.7 0.2 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain eIF2A PF08662.11 VDK76075.1 - 2e-07 31.1 0.0 0.012 15.5 0.0 4.0 3 1 1 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 VDK76075.1 - 7.1e-05 22.6 0.5 3.9 7.5 0.0 4.4 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 VDK76075.1 - 0.0014 18.0 0.0 2.8 7.2 0.0 3.9 5 0 0 5 5 5 1 WD40-like domain Frtz PF11768.8 VDK76075.1 - 0.0031 15.9 0.0 0.19 10.0 0.0 2.3 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 VDK76075.1 - 0.065 11.9 3.4 6.5 5.3 0.6 4.0 2 1 2 4 4 4 0 Nucleoporin Nup120/160 Methyltransf_16 PF10294.9 VDK76076.1 - 2.9e-18 66.2 0.0 5.9e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase CENP-S PF15630.6 VDK76076.1 - 1.6e-09 38.0 0.1 4.6e-09 36.5 0.1 1.8 1 0 0 1 1 1 1 CENP-S protein Methyltransf_11 PF08241.12 VDK76076.1 - 9e-08 32.7 0.0 2.5e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK76076.1 - 3.7e-07 30.8 0.1 1.5e-06 28.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK76076.1 - 1.4e-06 28.3 0.0 2.7e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK76076.1 - 9.1e-06 25.5 0.0 1.9e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 VDK76076.1 - 1.7e-05 24.3 0.0 3.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 VDK76076.1 - 0.00015 22.4 0.1 0.00088 20.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 VDK76076.1 - 0.00083 18.9 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 VDK76076.1 - 0.0019 17.7 0.0 0.004 16.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CENP-T_C PF15511.6 VDK76076.1 - 0.0027 17.8 0.2 0.015 15.4 0.0 2.1 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold UDPG_MGDP_dh_N PF03721.14 VDK76076.1 - 0.082 12.5 0.2 0.87 9.1 0.1 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain WAC_Acf1_DNA_bd PF10537.9 VDK76079.1 - 6.1e-31 106.9 0.0 2.5e-30 105.0 0.0 2.2 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal Bromodomain PF00439.25 VDK76079.1 - 1.9e-24 85.5 4.1 1.4e-23 82.8 0.4 3.2 3 0 0 3 3 3 1 Bromodomain WSD PF15613.6 VDK76079.1 - 2.1e-11 44.2 0.0 2.1e-11 44.2 0.0 3.5 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 VDK76079.1 - 6e-05 23.3 0.0 0.00023 21.4 0.0 2.0 1 0 0 1 1 1 1 DDT domain PHD PF00628.29 VDK76079.1 - 7e-05 22.6 16.2 7e-05 22.6 16.2 2.1 2 0 0 2 2 2 1 PHD-finger WHIM1 PF15612.6 VDK76079.1 - 0.018 14.6 0.0 0.049 13.2 0.0 1.8 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 DS PF01916.17 VDK76081.1 - 2.1e-116 388.2 0.0 2.8e-116 387.8 0.0 1.2 1 0 0 1 1 1 1 Deoxyhypusine synthase SPRY PF00622.28 VDK76081.1 - 3.3e-15 56.3 0.5 6.2e-08 32.8 0.0 2.8 3 0 0 3 3 3 2 SPRY domain PHD PF00628.29 VDK76081.1 - 0.012 15.4 5.3 0.035 14.0 5.3 1.8 1 0 0 1 1 1 0 PHD-finger ArlS_N PF18719.1 VDK76081.1 - 0.18 12.0 0.4 0.39 10.9 0.4 1.5 1 0 0 1 1 1 0 ArlS sensor domain LRR_4 PF12799.7 VDK76114.1 - 2.4e-29 100.9 40.9 1.9e-07 31.3 6.9 7.2 1 1 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDK76114.1 - 1.2e-21 77.0 23.4 5.1e-08 32.6 1.2 4.0 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 VDK76114.1 - 2.3e-19 68.9 32.6 7.8e-05 22.4 0.1 7.0 2 2 4 7 7 7 6 Leucine rich repeat LRR_6 PF13516.6 VDK76114.1 - 8.5e-07 28.5 20.6 0.5 10.5 0.2 7.6 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 VDK76114.1 - 3.3e-05 23.8 28.2 1.3 9.9 0.9 8.7 8 2 0 8 8 8 3 Leucine Rich Repeat FNIP PF05725.12 VDK76114.1 - 0.00052 20.1 0.0 1.8 8.8 0.3 4.9 2 2 0 2 2 2 1 FNIP Repeat Ribosomal_L50 PF10501.9 VDK76114.1 - 0.3 11.2 4.2 0.81 9.8 0.5 2.7 2 1 1 3 3 3 0 Ribosomal subunit 39S zf-BED PF02892.15 VDK76117.1 - 9.9e-08 31.9 0.2 2.4e-07 30.7 0.2 1.7 1 0 0 1 1 1 1 BED zinc finger Importin_rep_4 PF18808.1 VDK76117.1 - 3.1 8.2 6.3 5 7.5 4.6 2.2 1 1 1 2 2 2 0 Importin repeat T4_Gp59_N PF08993.10 VDK76119.1 - 0.086 13.3 0.1 0.26 11.7 0.0 1.8 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase LPD34 PF18852.1 VDK76119.1 - 0.13 11.8 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 Acetyltransf_18 PF18014.1 VDK76124.1 - 1e-06 28.6 0.0 4.2e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain AurF PF11583.8 VDK76124.1 - 0.17 11.1 0.2 0.68 9.2 0.1 1.8 2 0 0 2 2 2 0 P-aminobenzoate N-oxygenase AurF ABC_tran PF00005.27 VDK76125.1 - 3.5e-36 124.7 0.0 3e-18 66.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 VDK76125.1 - 1.1e-10 41.2 4.8 1.1e-10 41.2 4.8 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 VDK76125.1 - 1.6e-10 40.8 6.2 0.0038 16.7 0.1 4.1 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 VDK76125.1 - 9e-10 38.8 2.7 0.11 12.3 0.9 4.4 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 VDK76125.1 - 8.6e-08 31.7 3.3 8.6e-08 31.7 3.3 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_22 PF13401.6 VDK76125.1 - 3.3e-06 27.4 0.4 0.0018 18.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 VDK76125.1 - 7.6e-06 25.9 0.7 0.061 13.2 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase AAA PF00004.29 VDK76125.1 - 8.8e-06 26.2 0.0 0.053 13.9 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Fer4_7 PF12838.7 VDK76125.1 - 1.5e-05 25.5 6.7 0.00032 21.2 0.2 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain NACHT PF05729.12 VDK76125.1 - 1.6e-05 24.8 0.3 0.0068 16.3 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 VDK76125.1 - 1.9e-05 25.1 0.0 0.33 11.3 0.0 3.0 2 2 0 2 2 2 2 AAA ATPase domain Fer4_6 PF12837.7 VDK76125.1 - 2.3e-05 24.3 1.8 2.3e-05 24.3 1.8 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_15 PF13175.6 VDK76125.1 - 0.00011 22.0 0.1 0.23 11.1 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain Fer4_21 PF14697.6 VDK76125.1 - 0.00017 21.6 13.0 0.00034 20.7 13.0 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain TsaE PF02367.17 VDK76125.1 - 0.00021 21.3 1.1 0.14 12.2 0.0 3.3 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 VDK76125.1 - 0.00039 20.4 0.6 0.7 9.8 0.1 3.2 2 1 0 3 3 3 1 Rad17 P-loop domain AAA_29 PF13555.6 VDK76125.1 - 0.00062 19.5 1.4 0.76 9.6 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain Fer4_9 PF13187.6 VDK76125.1 - 0.00099 19.2 12.7 0.002 18.2 12.7 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain SRP54 PF00448.22 VDK76125.1 - 0.001 18.8 1.8 0.24 11.0 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 VDK76125.1 - 0.0014 18.8 0.0 2.2 8.5 0.0 3.5 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 VDK76125.1 - 0.0016 18.8 0.0 1.9 8.9 0.0 2.8 2 0 0 2 2 2 1 RNA helicase Fer4_16 PF13484.6 VDK76125.1 - 0.0017 19.3 6.0 0.0078 17.1 0.3 2.7 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain AAA_23 PF13476.6 VDK76125.1 - 0.0026 18.3 3.2 0.1 13.1 0.4 2.8 2 0 0 2 2 2 1 AAA domain Fer4_10 PF13237.6 VDK76125.1 - 0.0026 17.8 15.2 0.0093 16.1 2.3 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_28 PF13521.6 VDK76125.1 - 0.004 17.4 0.0 1.8 8.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.6 VDK76125.1 - 0.0042 17.6 0.0 5.9 7.4 0.0 3.0 2 0 0 2 2 2 0 AAA domain Fer4_2 PF12797.7 VDK76125.1 - 0.0048 16.9 10.6 0.0087 16.1 1.8 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain RuvB_N PF05496.12 VDK76125.1 - 0.0066 16.2 0.1 0.25 11.1 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NB-ARC PF00931.22 VDK76125.1 - 0.015 14.5 0.0 1.5 7.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 VDK76125.1 - 0.016 15.0 0.4 1.2 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain VirE PF05272.11 VDK76125.1 - 0.031 14.0 0.0 4.4 7.0 0.0 2.5 2 0 0 2 2 2 0 Virulence-associated protein E AAA_5 PF07728.14 VDK76125.1 - 0.045 13.7 0.7 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 VDK76125.1 - 0.046 13.4 2.1 3.3 7.4 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 VDK76125.1 - 0.048 13.2 0.0 1.7 8.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Thymidylate_kin PF02223.17 VDK76125.1 - 0.07 12.8 0.1 4.3 7.0 0.0 2.6 2 0 0 2 2 2 0 Thymidylate kinase NTPase_1 PF03266.15 VDK76125.1 - 0.16 11.8 2.9 16 5.4 0.0 3.6 3 0 0 3 3 3 0 NTPase Fer4_8 PF13183.6 VDK76125.1 - 0.55 10.7 10.2 0.22 12.0 1.1 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain MMR_HSR1 PF01926.23 VDK76125.1 - 0.76 9.9 2.5 28 4.8 0.1 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase Fer4_4 PF12800.7 VDK76125.1 - 0.8 10.4 16.3 0.27 11.8 3.0 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain AAA_14 PF13173.6 VDK76125.1 - 1.1 9.3 5.1 9.7 6.2 0.1 3.2 3 2 1 4 4 2 0 AAA domain Fer4_17 PF13534.6 VDK76125.1 - 1.6 9.3 12.2 19 5.9 12.4 2.4 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 VDK76125.1 - 5.9 8.1 15.5 0.33 12.0 3.9 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain DEAD PF00270.29 VDK76126.1 - 2.9e-12 46.7 0.0 7.3e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK76126.1 - 7.5e-11 42.3 0.0 2.1e-10 40.9 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 VDK76126.1 - 5.4e-08 33.2 0.0 2.3e-07 31.1 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain WBS_methylT PF12589.8 VDK76127.1 - 7e-16 58.8 5.0 1.2e-15 58.0 5.0 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 VDK76127.1 - 3e-11 43.8 0.0 9e-11 42.3 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK76127.1 - 3.7e-11 43.6 0.0 1.1e-10 42.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK76127.1 - 3.8e-07 30.0 0.0 8.1e-07 29.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK76127.1 - 5.8e-06 26.2 0.0 8.2e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK76127.1 - 4.1e-05 24.3 0.0 8.7e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain N6_N4_Mtase PF01555.18 VDK76127.1 - 0.00094 18.9 0.0 0.0051 16.6 0.0 1.9 2 0 0 2 2 2 1 DNA methylase PCMT PF01135.19 VDK76127.1 - 0.012 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 VDK76127.1 - 0.029 13.6 0.0 0.052 12.8 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 VDK76127.1 - 0.04 13.3 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 VDK76127.1 - 0.067 12.5 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AdoMet_MTase PF07757.13 VDK76127.1 - 0.083 13.2 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase TPMT PF05724.11 VDK76127.1 - 0.099 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) UNC-50 PF05216.13 VDK76130.1 - 1.4e-81 273.3 25.0 1.6e-81 273.1 25.0 1.0 1 0 0 1 1 1 1 UNC-50 family DUF2205 PF10224.9 VDK76132.1 - 6e-26 90.2 0.7 7.9e-26 89.9 0.7 1.1 1 0 0 1 1 1 1 Short coiled-coil protein CENP-H PF05837.12 VDK76132.1 - 0.0039 17.6 2.2 0.0051 17.2 2.2 1.2 1 0 0 1 1 1 1 Centromere protein H (CENP-H) TACC_C PF05010.14 VDK76132.1 - 0.0055 16.5 0.3 0.0075 16.1 0.3 1.1 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal FliT PF05400.13 VDK76132.1 - 0.0078 17.0 1.2 0.0078 17.0 1.2 1.5 2 0 0 2 2 1 1 Flagellar protein FliT UPF0242 PF06785.11 VDK76132.1 - 0.013 15.6 1.3 0.013 15.6 1.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Sas10_Utp3 PF04000.15 VDK76132.1 - 0.015 15.9 0.3 0.023 15.3 0.3 1.4 1 0 0 1 1 1 0 Sas10/Utp3/C1D family KASH_CCD PF14662.6 VDK76132.1 - 0.016 15.0 4.2 0.021 14.7 4.2 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH YabA PF06156.13 VDK76132.1 - 0.021 15.5 1.2 0.028 15.0 1.2 1.2 1 0 0 1 1 1 0 Initiation control protein YabA HalX PF08663.10 VDK76132.1 - 0.022 15.1 2.7 0.035 14.4 2.7 1.3 1 0 0 1 1 1 0 HalX domain FlaC_arch PF05377.11 VDK76132.1 - 0.036 14.5 1.4 0.058 13.8 1.4 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Myosin_tail_1 PF01576.19 VDK76132.1 - 0.039 11.8 3.8 0.049 11.4 3.8 1.0 1 0 0 1 1 1 0 Myosin tail V_ATPase_I PF01496.19 VDK76132.1 - 0.078 10.9 0.1 0.081 10.8 0.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HALZ PF02183.18 VDK76132.1 - 0.13 12.5 5.8 2.4 8.5 0.8 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper FlxA PF14282.6 VDK76132.1 - 0.76 9.8 6.9 1.2 9.2 6.9 1.2 1 0 0 1 1 1 0 FlxA-like protein Linker_histone PF00538.19 VDK76134.1 - 1.7e-25 89.2 0.1 1.7e-25 89.2 0.1 2.3 2 1 0 2 2 2 1 linker histone H1 and H5 family Chorion_2 PF03964.15 VDK76135.1 - 0.54 11.1 3.8 0.2 12.5 0.4 2.0 2 0 0 2 2 2 0 Chorion family 2 Arf PF00025.21 VDK76139.1 - 7.7e-34 116.6 0.0 9.3e-34 116.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 VDK76139.1 - 0.0011 18.4 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 VDK76139.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Sema PF01403.19 VDK76169.1 - 1.4e-106 356.9 0.0 1.8e-106 356.5 0.0 1.1 1 0 0 1 1 1 1 Sema domain PSI PF01437.25 VDK76169.1 - 1.7e-06 28.5 2.7 1.7e-06 28.5 2.7 2.2 2 0 0 2 2 2 1 Plexin repeat PSI_integrin PF17205.3 VDK76169.1 - 0.015 15.1 0.9 0.038 13.7 0.9 1.7 1 0 0 1 1 1 0 Integrin plexin domain DIL PF01843.19 VDK76172.1 - 4.9e-24 84.6 0.1 2.6e-23 82.3 0.1 2.3 1 0 0 1 1 1 1 DIL domain PDZ PF00595.24 VDK76172.1 - 3.1e-14 53.1 1.0 1e-13 51.4 1.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK76172.1 - 7.3e-09 35.4 0.0 1.5e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK76172.1 - 0.00013 22.2 0.1 0.00047 20.4 0.1 2.0 1 0 0 1 1 1 1 PDZ domain DUF5344 PF17279.2 VDK76172.1 - 1.5 9.5 5.9 32 5.2 0.4 4.4 4 0 0 4 4 4 0 Family of unknown function (DUF5344) RA PF00788.23 VDK76174.1 - 2.4e-33 114.6 0.2 3.2e-18 66.1 0.0 2.6 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain FHA PF00498.26 VDK76174.1 - 1.8e-05 25.0 0.8 3.7e-05 24.0 0.2 1.9 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 VDK76174.1 - 0.00022 21.4 0.0 0.0005 20.3 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_3 PF13920.6 VDK76176.1 - 4.6e-08 32.8 12.3 4.6e-08 32.8 12.3 3.3 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK76176.1 - 0.00082 19.2 9.0 0.00082 19.2 9.0 3.3 2 2 0 2 2 2 1 Prokaryotic RING finger family 4 HLH PF00010.26 VDK76177.1 - 1.5e-08 34.4 0.0 2.9e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain MG2 PF01835.19 VDK76199.1 - 6e-13 49.1 0.1 1.3e-12 48.0 0.0 1.6 2 0 0 2 2 2 1 MG2 domain MG3 PF17791.1 VDK76199.1 - 0.027 14.8 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 Macroglobulin domain MG3 A2M PF00207.22 VDK76200.1 - 2e-11 43.6 0.3 5e-11 42.3 0.3 1.7 1 0 0 1 1 1 1 Alpha-2-macroglobulin family A2M_BRD PF07703.14 VDK76200.1 - 6.7e-10 39.5 0.0 2.7e-09 37.5 0.0 2.1 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain HPS3_C PF14763.6 VDK76200.1 - 0.088 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3, C-terminal Methyltransf_25 PF13649.6 VDK76201.1 - 0.0052 17.5 0.0 0.0099 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK76201.1 - 0.0074 17.0 0.0 0.012 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK76201.1 - 0.011 15.6 0.1 0.027 14.3 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 VDK76201.1 - 0.021 14.6 0.1 0.031 14.0 0.1 1.2 1 0 0 1 1 1 0 Met-10+ like-protein CheR PF01739.18 VDK76201.1 - 0.047 13.2 0.0 0.074 12.5 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain LCM PF04072.14 VDK76202.1 - 1.2e-27 97.1 0.0 1.7e-27 96.6 0.0 1.3 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase CBM_19 PF03427.13 VDK76204.1 - 0.0014 18.5 0.3 0.0047 16.9 0.3 1.9 1 0 0 1 1 1 1 Carbohydrate binding domain (family 19) TSP_1 PF00090.19 VDK76205.1 - 2e-54 181.6 186.2 1.1e-09 38.3 10.8 12.6 14 0 0 14 14 14 9 Thrombospondin type 1 domain FLYWCH PF04500.16 VDK76216.1 - 0.0099 16.0 0.2 0.0099 16.0 0.2 1.9 2 0 0 2 2 2 1 FLYWCH zinc finger domain Pkinase PF00069.25 VDK76219.1 - 2.1e-63 214.2 0.0 2.1e-63 214.2 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK76219.1 - 2.1e-62 210.7 0.0 3.7e-62 209.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 VDK76219.1 - 0.001 18.7 1.3 0.0034 17.0 0.1 2.6 2 1 0 2 2 2 1 RIO1 family Kinase-like PF14531.6 VDK76219.1 - 0.0035 16.7 0.0 0.0076 15.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 VDK76219.1 - 0.04 13.8 0.1 0.04 13.8 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF5071 PF16804.5 VDK76219.1 - 0.1 12.8 0.6 1 9.6 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5071) DUF3288 PF11691.8 VDK76219.1 - 0.25 11.4 2.5 0.97 9.5 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3288) DUF2951 PF11166.8 VDK76219.1 - 0.58 10.4 3.2 1.4 9.2 3.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Met_10 PF02475.16 VDK76223.1 - 1.3e-49 168.7 0.0 3.5e-49 167.3 0.0 1.7 1 0 0 1 1 1 1 Met-10+ like-protein tRNA-synt_2b PF00587.25 VDK76223.1 - 2.6e-25 89.4 0.0 6.5e-25 88.1 0.0 1.7 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TRM PF02005.16 VDK76223.1 - 0.00022 20.5 0.3 0.0011 18.2 0.3 2.0 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase HGTP_anticodon PF03129.20 VDK76223.1 - 0.00077 19.6 0.0 0.0024 18.0 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain COesterase PF00135.28 VDK76225.1 - 4.6e-134 448.1 0.0 5.8e-134 447.8 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 VDK76225.1 - 3.5e-09 36.8 0.0 1.6e-08 34.7 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold OLF PF02191.16 VDK76227.1 - 4.7e-42 144.2 5.7 6e-41 140.6 5.7 2.0 1 1 0 1 1 1 1 Olfactomedin-like domain Collagen PF01391.18 VDK76227.1 - 5.4e-06 26.1 13.2 8.3e-06 25.5 13.2 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) UDPG_MGDP_dh_N PF03721.14 VDK76228.1 - 3.3e-63 212.6 0.0 6.7e-63 211.6 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 VDK76228.1 - 1.1e-32 112.5 0.1 8.4e-32 109.7 0.1 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 VDK76228.1 - 1.3e-27 95.9 0.0 3.1e-27 94.6 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.15 VDK76228.1 - 0.016 15.4 0.0 0.21 11.7 0.0 2.4 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 VDK76228.1 - 0.064 13.1 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 VDK76228.1 - 0.077 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 VDK76228.1 - 0.12 12.8 0.0 4 7.9 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding UIM PF02809.20 VDK76229.1 - 0.1 12.6 1.2 0.24 11.4 1.2 1.7 1 0 0 1 1 1 0 Ubiquitin interaction motif UDPGT PF00201.18 VDK76229.1 - 0.28 9.9 2.4 0.38 9.5 2.4 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase Nup54 PF13874.6 VDK76229.1 - 0.45 10.6 10.9 0.25 11.4 4.3 2.4 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 Macoilin PF09726.9 VDK76229.1 - 3.4 6.1 17.7 6.3 5.2 17.7 1.4 1 1 0 1 1 1 0 Macoilin family UQ_con PF00179.26 VDK76230.1 - 7.9e-50 168.2 0.0 9e-50 168.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PGI PF00342.19 VDK76231.1 - 2.4e-224 745.4 1.6 4.7e-223 741.2 1.6 2.0 1 1 0 1 1 1 1 Phosphoglucose isomerase CPSase_L_D3 PF02787.19 VDK76231.1 - 0.021 15.2 0.2 1.1 9.6 0.0 3.1 3 0 0 3 3 3 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Tsg PF04668.12 VDK76233.1 - 6.2e-27 94.9 7.0 6.2e-27 94.9 7.0 2.8 2 1 0 2 2 2 1 Twisted gastrulation (Tsg) protein conserved region GDPD PF03009.17 VDK76244.1 - 3e-46 158.3 0.0 3.7e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family COG6 PF06419.11 VDK76245.1 - 9.1e-152 506.5 18.8 1.2e-151 506.1 18.8 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Sec34 PF04136.15 VDK76245.1 - 5.9e-05 23.0 4.4 0.00018 21.4 2.9 2.7 1 1 0 1 1 1 1 Sec34-like family ATG16 PF08614.11 VDK76245.1 - 0.017 15.3 8.7 0.017 15.3 6.2 2.3 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF5082 PF16888.5 VDK76245.1 - 0.026 14.8 3.8 0.077 13.3 3.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) GCSF PF16647.5 VDK76245.1 - 0.039 13.8 0.2 0.12 12.2 0.2 1.8 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor Acetyltransf_11 PF13720.6 VDK76245.1 - 0.091 13.2 0.3 11 6.6 0.1 3.2 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Jnk-SapK_ap_N PF09744.9 VDK76245.1 - 0.45 10.7 10.0 0.3 11.3 4.1 2.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FAS_N PF17828.1 VDK76245.1 - 0.5 10.4 3.6 26 4.8 0.9 3.4 3 0 0 3 3 3 0 N-terminal domain in fatty acid synthase subunit beta YabA PF06156.13 VDK76245.1 - 0.69 10.6 5.4 0.93 10.2 2.4 2.7 1 1 1 2 2 2 0 Initiation control protein YabA NleF_casp_inhib PF16809.5 VDK76245.1 - 6 6.8 12.0 0.2 11.6 4.1 2.5 3 0 0 3 3 3 0 NleF caspase inhibitor GAT PF03127.14 VDK76245.1 - 6.2 7.2 7.5 24 5.4 0.8 4.3 3 1 0 3 3 3 0 GAT domain Rhomboid PF01694.22 VDK76246.1 - 4.1e-26 91.8 6.6 4.1e-26 91.8 6.6 1.7 2 0 0 2 2 2 1 Rhomboid family MFS_1 PF07690.16 VDK76247.1 - 9.5e-48 162.9 29.6 9.5e-48 162.9 29.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Amino_oxidase PF01593.24 VDK76248.1 - 7.2e-82 276.1 0.0 9.7e-82 275.6 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 VDK76248.1 - 2.5e-09 37.4 0.0 5.5e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 VDK76248.1 - 2.8e-09 37.1 1.8 5.2e-09 36.2 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain zf-CW PF07496.15 VDK76248.1 - 2.4e-08 33.8 4.2 8.2e-08 32.2 4.2 2.0 1 0 0 1 1 1 1 CW-type Zinc Finger Pyr_redox_2 PF07992.14 VDK76248.1 - 1.8e-06 27.4 0.1 0.00046 19.5 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 VDK76248.1 - 1.9e-06 27.3 0.2 3.4e-06 26.5 0.2 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 VDK76248.1 - 3.6e-06 25.9 0.7 0.00055 18.8 0.6 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.27 VDK76248.1 - 2.1e-05 25.0 0.4 5.3e-05 23.7 0.2 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 VDK76248.1 - 2.9e-05 23.8 0.6 0.00023 20.9 0.4 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 VDK76248.1 - 8e-05 22.2 0.3 0.00014 21.4 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 VDK76248.1 - 0.00053 19.4 0.0 0.00095 18.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 VDK76248.1 - 0.00088 18.5 3.0 0.0014 17.7 3.0 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 VDK76248.1 - 0.00097 18.5 0.2 0.002 17.5 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 VDK76248.1 - 0.0056 16.0 0.0 0.041 13.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 VDK76248.1 - 0.012 14.7 0.1 2.9 6.9 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 VDK76248.1 - 0.061 12.4 0.6 0.11 11.5 0.6 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 VDK76248.1 - 0.15 12.0 0.4 6.3 6.8 0.2 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 VDK76248.1 - 0.18 12.3 0.1 0.4 11.1 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding LAP1C PF05609.12 VDK76248.1 - 3.3 6.7 8.3 4.8 6.2 8.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) MTP18 PF10558.9 VDK76249.1 - 2.8e-17 63.2 1.4 5.9e-08 32.8 0.1 2.1 1 1 1 2 2 2 2 Mitochondrial 18 KDa protein (MTP18) DEAD PF00270.29 VDK76250.1 - 2.2e-41 141.6 0.0 3.5e-41 140.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK76250.1 - 7.5e-16 58.5 1.1 1.5e-13 51.1 0.2 3.2 2 2 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK76250.1 - 0.018 15.0 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 VDK76250.1 - 0.024 14.9 0.2 0.91 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Homeodomain PF00046.29 VDK76251.1 - 1.1e-18 66.8 4.7 1.9e-18 66.0 4.7 1.4 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 VDK76251.1 - 4.1e-16 58.9 20.3 3.5e-08 33.6 1.8 2.4 2 0 0 2 2 2 2 LIM domain Homeobox_KN PF05920.11 VDK76251.1 - 1.1e-05 25.2 1.0 2.5e-05 24.1 0.2 1.9 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 VDK76251.1 - 0.021 14.3 0.0 0.051 13.0 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez MADF_DNA_bdg PF10545.9 VDK76251.1 - 0.71 10.2 5.2 3 8.2 0.2 2.4 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF236 PF03057.14 VDK76252.1 - 8.9e-59 195.1 34.1 2.5e-16 59.3 1.4 5.4 5 0 0 5 5 5 5 DUF236 repeat DUF2201_N PF13203.6 VDK76253.1 - 0.0048 16.5 2.4 0.0048 16.5 2.4 2.7 1 1 1 2 2 2 1 Putative metallopeptidase domain TssN PF17555.2 VDK76255.1 - 0.029 13.8 4.5 0.027 13.9 3.8 1.3 1 1 0 1 1 1 0 Type VI secretion system, TssN Glyco_hydro_47 PF01532.20 VDK76257.1 - 3.5e-150 500.9 0.2 4.1e-150 500.7 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 XK-related PF09815.9 VDK76276.1 - 1.3e-81 274.4 30.3 1.6e-81 274.1 30.3 1.1 1 0 0 1 1 1 1 XK-related protein PMT_4TMC PF16192.5 VDK76276.1 - 3 7.4 18.4 0.39 10.3 12.4 2.4 1 1 1 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase Forkhead PF00250.18 VDK76277.1 - 7.4e-39 131.9 0.0 1.3e-38 131.1 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 VDK76277.1 - 0.11 12.9 0.1 0.24 11.8 0.1 1.5 1 0 0 1 1 1 0 linker histone H1 and H5 family LANC_like PF05147.13 VDK76278.1 - 3.3e-56 190.4 0.2 7.1e-56 189.3 0.1 1.5 1 1 1 2 2 2 2 Lanthionine synthetase C-like protein Glyco_hydro_127 PF07944.12 VDK76278.1 - 0.0053 15.3 0.1 0.0079 14.7 0.1 1.3 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Glyco_transf_17 PF04724.13 VDK76278.1 - 0.036 13.1 0.0 0.061 12.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 17 Fungal_lectin_2 PF18647.1 VDK76278.1 - 0.083 13.3 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 Alpha-galactosyl-binding fungal lectin C5-epim_C PF06662.13 VDK76278.1 - 0.21 11.1 2.7 1.3 8.5 0.1 2.4 1 1 1 2 2 2 0 D-glucuronyl C5-epimerase C-terminus LANC_like PF05147.13 VDK76279.1 - 2.1e-55 187.7 0.3 2.5e-55 187.5 0.3 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein C5-epim_C PF06662.13 VDK76279.1 - 0.026 14.1 0.2 0.11 11.9 0.1 2.0 1 1 1 2 2 2 0 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 VDK76279.1 - 0.084 11.3 0.0 0.11 11.0 0.0 1.2 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 DUF2961 PF11175.8 VDK76280.1 - 0.016 14.9 0.0 0.016 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2961) FA_desaturase PF00487.24 VDK76282.1 - 1.1e-29 104.1 21.3 1.7e-29 103.4 21.3 1.3 1 0 0 1 1 1 1 Fatty acid desaturase PSI_integrin PF17205.3 VDK76282.1 - 0.43 10.4 1.2 1 9.1 1.2 1.6 1 0 0 1 1 1 0 Integrin plexin domain CBM_14 PF01607.24 VDK76283.1 - 2.7e-06 27.4 19.5 4.5e-06 26.7 0.3 4.2 3 0 0 3 3 3 2 Chitin binding Peritrophin-A domain DUF5401 PF17380.2 VDK76283.1 - 0.088 10.9 0.7 0.16 10.0 0.2 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5401) Troponin-I_N PF11636.8 VDK76284.1 - 0.11 12.5 1.4 0.27 11.2 1.4 1.7 1 0 0 1 1 1 0 Troponin I residues 1-32 Ras PF00071.22 VDK76285.1 - 9e-48 161.9 0.0 1.1e-47 161.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK76285.1 - 6.7e-31 107.0 0.0 9.1e-31 106.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK76285.1 - 5.2e-16 58.6 0.0 5.9e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK76285.1 - 7.2e-06 26.1 0.0 9.3e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK76285.1 - 0.00014 21.3 0.0 0.00017 21.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TniB PF05621.11 VDK76285.1 - 0.019 14.4 0.0 0.063 12.7 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein SRPRB PF09439.10 VDK76285.1 - 0.021 14.3 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 VDK76285.1 - 0.064 13.3 0.0 0.15 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 VDK76285.1 - 0.089 12.3 0.0 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B Arf PF00025.21 VDK76288.1 - 1.7e-74 249.1 0.1 1.9e-74 248.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK76288.1 - 2.8e-15 56.6 0.1 4e-15 56.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK76288.1 - 3.1e-13 49.6 0.0 3.7e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 VDK76288.1 - 5e-11 42.4 0.7 3.1e-07 29.9 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 VDK76288.1 - 1.3e-09 37.7 0.0 1.4e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 VDK76288.1 - 2.1e-09 37.1 0.0 2.5e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK76288.1 - 1.8e-05 24.8 0.0 4.9e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 VDK76288.1 - 0.0065 17.0 0.0 0.0099 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 VDK76288.1 - 0.01 15.8 0.0 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase MeaB PF03308.16 VDK76288.1 - 0.012 14.6 0.0 0.36 9.8 0.0 2.2 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PduV-EutP PF10662.9 VDK76288.1 - 0.026 14.3 0.1 5.7 6.7 0.0 2.7 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 VDK76288.1 - 0.041 13.5 0.3 8.5 5.9 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SelB-wing_2 PF09106.11 VDK76288.1 - 0.078 13.2 0.0 0.23 11.7 0.0 1.7 2 0 0 2 2 2 0 Elongation factor SelB, winged helix ABC_tran PF00005.27 VDK76288.1 - 0.099 13.2 0.3 0.23 12.0 0.3 1.8 1 1 0 1 1 1 0 ABC transporter DHHC PF01529.20 VDK76290.1 - 6e-34 117.0 14.9 7.1e-34 116.8 14.9 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase Ank_2 PF12796.7 VDK76291.1 - 1.5e-39 134.4 5.5 2.4e-17 63.3 0.2 3.7 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK76291.1 - 7.8e-26 90.1 5.4 1.9e-13 50.6 0.3 4.7 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK76291.1 - 4.1e-25 87.5 10.2 8.4e-09 35.5 0.4 4.6 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK76291.1 - 9.1e-25 84.0 2.6 5.7e-05 23.2 0.2 6.7 6 0 0 6 6 6 4 Ankyrin repeat Ank PF00023.30 VDK76291.1 - 3.8e-23 80.9 6.0 2.8e-06 27.5 1.3 6.8 6 1 1 7 7 7 4 Ankyrin repeat Strabismus PF06638.11 VDK76292.1 - 5.3e-135 450.9 0.0 6.4e-135 450.7 0.0 1.0 1 0 0 1 1 1 1 Strabismus protein USP7_C2 PF14533.6 VDK76293.1 - 6.4e-54 182.8 1.3 4.5e-50 170.2 0.2 3.0 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 VDK76293.1 - 4.2e-47 160.8 0.1 7.3e-47 160.0 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 VDK76293.1 - 3.6e-27 95.2 0.0 7.7e-25 87.6 0.0 2.3 1 1 1 2 2 2 2 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 VDK76293.1 - 1.5e-18 67.5 0.0 4.7e-18 65.9 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 VDK76293.1 - 6.7e-12 45.6 0.0 4e-11 43.1 0.0 2.3 2 0 0 2 2 2 1 MATH domain UN_NPL4 PF11543.8 VDK76293.1 - 0.00018 21.9 2.5 0.33 11.5 0.1 4.0 4 0 0 4 4 4 1 Nuclear pore localisation protein NPL4 RA PF00788.23 VDK76293.1 - 0.051 14.2 0.3 1.8 9.3 0.0 3.3 4 0 0 4 4 4 0 Ras association (RalGDS/AF-6) domain Lipocalin_2 PF08212.12 VDK76295.1 - 8.5e-05 22.5 1.7 0.0003 20.7 1.7 1.9 1 1 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 VDK76295.1 - 0.021 15.0 1.3 0.056 13.6 1.3 1.7 1 1 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family ThiF PF00899.21 VDK76316.1 - 1.6e-105 351.8 0.0 3.8e-73 245.8 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 VDK76316.1 - 3.4e-89 299.1 5.4 3.4e-89 299.1 5.4 1.7 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 VDK76316.1 - 9.1e-29 100.0 1.3 9.1e-29 100.0 1.3 2.0 2 0 0 2 2 2 1 Ubiquitin fold domain E1_FCCH PF16190.5 VDK76316.1 - 1.8e-26 92.1 0.3 3.6e-26 91.1 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 VDK76316.1 - 1.3e-17 63.8 0.3 3.5e-17 62.4 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Shikimate_DH PF01488.20 VDK76316.1 - 0.0002 21.5 0.3 0.061 13.4 0.0 2.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 VDK76316.1 - 0.00031 20.2 0.1 0.097 12.0 0.0 2.6 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 VDK76316.1 - 0.057 12.6 0.1 0.37 10.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 VDK76316.1 - 0.084 13.4 2.6 3.5 8.3 0.6 3.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ELFV_dehydrog PF00208.21 VDK76316.1 - 1 9.0 3.1 1.6 8.4 0.0 2.6 3 0 0 3 3 3 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Peptidase_M17 PF00883.21 VDK76317.1 - 2.5e-52 178.1 0.0 3.7e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain CPP1-like PF11833.8 VDK76318.1 - 0.0016 18.2 9.0 0.002 17.8 9.0 1.1 1 0 0 1 1 1 1 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF998 PF06197.13 VDK76318.1 - 0.024 14.3 0.2 0.024 14.3 0.2 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF998) DUF2723 PF11028.8 VDK76318.1 - 0.2 11.5 4.7 0.14 12.1 1.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2723) EMP70 PF02990.16 VDK76318.1 - 0.4 9.3 7.9 0.5 9.0 7.9 1.0 1 0 0 1 1 1 0 Endomembrane protein 70 Pkinase PF00069.25 VDK76319.1 - 6.4e-60 202.8 0.0 9.8e-60 202.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.22 VDK76319.1 - 1.3e-53 182.4 0.2 2.4e-53 181.5 0.2 1.5 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.17 VDK76319.1 - 1.4e-37 129.4 0.0 3.9e-37 128.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK76319.1 - 4.5e-05 22.4 0.0 9.6e-05 21.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 VDK76319.1 - 0.00017 21.0 0.0 0.00039 19.8 0.0 1.5 1 0 0 1 1 1 1 Kinase-like UAA PF08449.11 VDK76320.1 - 4.3e-57 193.6 17.4 5.4e-57 193.3 17.4 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 VDK76320.1 - 9.3e-10 38.8 21.2 4.1e-05 23.8 12.5 3.0 3 2 0 3 3 3 2 EamA-like transporter family TPT PF03151.16 VDK76320.1 - 6.1e-06 25.8 1.9 6.1e-06 25.8 1.9 1.7 2 0 0 2 2 2 1 Triose-phosphate Transporter family HAT PF02184.16 VDK76321.1 - 3.5e-30 103.6 51.9 4.2e-16 58.6 2.6 12.7 13 1 0 13 13 13 5 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 VDK76321.1 - 8.6e-14 51.1 28.4 0.052 14.4 0.1 10.8 5 3 7 12 12 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 VDK76321.1 - 5.3e-12 46.1 2.0 0.024 15.1 0.1 6.2 4 2 3 8 8 7 3 Tetratricopeptide repeat Suf PF05843.14 VDK76321.1 - 1.9e-10 41.2 25.7 5.8e-06 26.5 4.3 6.5 3 3 2 5 5 5 3 Suppressor of forked protein (Suf) TPR_17 PF13431.6 VDK76321.1 - 1.5e-07 31.3 2.4 0.035 14.5 0.0 6.0 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK76321.1 - 2.3e-07 31.4 9.1 1.4 9.7 0.0 6.5 5 1 1 6 6 6 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 VDK76321.1 - 2.7e-07 30.6 23.4 0.0013 18.7 4.1 6.1 4 3 1 5 5 5 2 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 VDK76321.1 - 0.00041 20.3 12.9 13 6.2 0.0 7.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK76321.1 - 0.0016 18.5 1.0 50 4.5 0.1 5.5 5 0 0 5 5 4 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 VDK76321.1 - 0.0056 16.7 17.7 0.017 15.2 0.8 6.0 5 1 1 6 6 6 1 U3 small nucleolar RNA-associated protein 6 TPR_6 PF13174.6 VDK76321.1 - 0.0063 17.1 9.4 62 4.5 0.0 8.3 10 0 0 10 10 9 0 Tetratricopeptide repeat SNAP PF14938.6 VDK76321.1 - 0.0084 15.6 3.5 1.5 8.1 0.0 4.0 3 2 2 5 5 5 1 Soluble NSF attachment protein, SNAP TPR_9 PF13371.6 VDK76321.1 - 0.045 13.9 9.6 2.1 8.6 0.0 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 VDK76321.1 - 0.072 13.4 8.2 6.7 7.1 0.2 5.4 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 VDK76321.1 - 0.26 12.0 2.0 65 4.6 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat Piwi PF02171.17 VDK76322.1 - 5.7e-53 180.1 0.0 9.2e-53 179.4 0.0 1.3 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 VDK76322.1 - 0.0007 20.2 0.0 0.0019 18.8 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 VDK76322.1 - 0.0015 18.8 0.0 0.0051 17.1 0.0 2.0 1 0 0 1 1 1 1 Argonaute linker 2 domain CBFD_NFYB_HMF PF00808.23 VDK76323.1 - 7.3e-09 35.8 0.7 1.1e-08 35.2 0.7 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RFX5_DNA_bdg PF14621.6 VDK76323.1 - 0.019 14.7 0.2 0.031 14.1 0.2 1.3 1 0 0 1 1 1 0 RFX5 DNA-binding domain DUF1876 PF08962.11 VDK76323.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1876) Histone PF00125.24 VDK76323.1 - 0.35 11.2 0.1 0.35 11.2 0.1 2.4 3 0 0 3 3 3 0 Core histone H2A/H2B/H3/H4 Prenyltrans PF00432.21 VDK76324.1 - 1.7e-45 152.4 12.3 8.1e-11 41.5 0.0 6.2 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 VDK76324.1 - 8.1e-06 25.1 0.1 0.089 11.9 0.0 3.4 1 1 2 3 3 3 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 VDK76324.1 - 0.00097 18.3 0.0 3.4 6.7 0.0 3.3 2 1 1 3 3 3 2 Squalene-hopene cyclase N-terminal domain CBF PF03914.17 VDK76325.1 - 1.1e-37 129.7 1.2 1.1e-37 129.7 1.2 2.9 3 1 0 3 3 3 1 CBF/Mak21 family CRR7 PF12095.8 VDK76325.1 - 0.016 15.7 0.3 0.078 13.4 0.3 2.2 1 0 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 Nop14 PF04147.12 VDK76325.1 - 6.5 4.8 28.4 14 3.7 28.4 1.6 1 0 0 1 1 1 0 Nop14-like family Ribonuclease_T2 PF00445.18 VDK76326.1 - 5.3e-52 176.7 2.2 6.3e-52 176.5 2.2 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family WH1 PF00568.23 VDK76327.1 - 4.4e-21 74.9 0.0 7.1e-21 74.2 0.0 1.3 1 0 0 1 1 1 1 WH1 domain VASP_tetra PF08776.11 VDK76327.1 - 1.9e-10 40.1 1.8 3.4e-10 39.3 1.8 1.4 1 0 0 1 1 1 1 VASP tetramerisation domain Mito_fiss_reg PF05308.11 VDK76327.1 - 0.0068 16.5 3.5 0.014 15.5 3.5 1.5 1 0 0 1 1 1 1 Mitochondrial fission regulator CAP_N PF01213.19 VDK76327.1 - 0.013 15.0 4.4 0.024 14.1 4.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TubC_N PF18563.1 VDK76327.1 - 0.078 13.0 1.4 0.22 11.5 0.4 2.2 2 0 0 2 2 2 0 TubC N-terminal docking domain Ran_BP1 PF00638.18 VDK76327.1 - 0.079 13.2 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 RanBP1 domain PRIMA1 PF16101.5 VDK76327.1 - 0.72 9.9 4.7 1.7 8.7 4.7 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EF-hand_7 PF13499.6 VDK76344.1 - 6.7e-14 52.1 1.1 3e-10 40.4 0.2 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK76344.1 - 2.5e-12 45.4 2.5 2.5e-05 23.5 0.2 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 VDK76344.1 - 7.8e-12 44.1 0.9 0.00022 20.9 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 VDK76344.1 - 1.3e-06 27.6 5.9 0.0029 17.0 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 VDK76344.1 - 1.6e-06 27.8 1.4 0.041 13.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 VDK76344.1 - 4.6e-05 23.7 0.0 0.0016 18.7 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 VDK76344.1 - 0.034 14.1 0.4 0.16 11.9 0.0 2.1 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDK76344.1 - 0.037 14.3 0.7 8.6 6.7 0.1 2.6 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Transcrip_reg PF01709.20 VDK76345.1 - 1.1e-35 123.2 1.5 1.2e-35 123.1 1.5 1.0 1 0 0 1 1 1 1 Transcriptional regulator TonB_N PF16031.5 VDK76349.1 - 0.11 13.0 4.3 0.16 12.5 4.3 1.4 1 0 0 1 1 1 0 TonB polyproline region ANTH PF07651.16 VDK76351.1 - 7.5e-62 208.8 0.5 7.5e-62 208.8 0.5 2.5 2 1 0 2 2 2 1 ANTH domain I_LWEQ PF01608.17 VDK76351.1 - 1.7e-50 171.2 10.1 1.7e-50 171.2 10.1 5.2 3 1 1 5 5 5 1 I/LWEQ domain ATG16 PF08614.11 VDK76351.1 - 0.0012 19.1 23.4 0.0012 19.1 23.4 5.0 2 2 2 4 4 4 2 Autophagy protein 16 (ATG16) RNA_pol_Rpb1_4 PF05000.17 VDK76351.1 - 0.02 14.8 0.2 0.02 14.8 0.2 3.2 2 1 0 2 2 2 0 RNA polymerase Rpb1, domain 4 AAA_24 PF13479.6 VDK76351.1 - 0.075 12.7 1.7 0.26 11.0 1.7 2.1 1 0 0 1 1 1 0 AAA domain SRR PF07709.11 VDK76351.1 - 0.88 10.2 2.5 43 5.1 0.0 3.1 2 0 0 2 2 2 0 Seven Residue Repeat Dak2 PF02734.17 VDK76351.1 - 1.5 8.7 5.4 18 5.1 2.7 2.9 2 1 0 2 2 2 0 DAK2 domain Tmemb_55A PF09788.9 VDK76352.1 - 9.7e-82 273.7 10.8 1.1e-81 273.5 10.8 1.0 1 0 0 1 1 1 1 Transmembrane protein 55A CK_II_beta PF01214.18 VDK76352.1 - 0.017 14.9 1.1 0.043 13.6 1.1 1.7 1 1 0 1 1 1 0 Casein kinase II regulatory subunit zf-RING_7 PF02591.15 VDK76352.1 - 2.1 8.6 11.9 6.5 7.0 0.0 4.1 3 1 0 3 3 3 0 C4-type zinc ribbon domain IBR PF01485.21 VDK76352.1 - 3.4 8.0 23.5 3.5e+02 1.5 0.4 3.9 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain Peptidase_M22 PF00814.25 VDK76353.1 - 3e-84 282.9 0.0 4.1e-84 282.5 0.0 1.2 1 0 0 1 1 1 1 Glycoprotease family DUF953 PF06110.11 VDK76354.1 - 1.8e-33 114.7 0.1 2.3e-33 114.3 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) OST3_OST6 PF04756.13 VDK76354.1 - 9.8e-05 21.8 0.0 0.00012 21.6 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 VDK76354.1 - 0.00078 19.2 0.3 0.0029 17.4 0.3 1.9 1 1 0 1 1 1 1 Thioredoxin Thioredoxin PF00085.20 VDK76354.1 - 0.0034 17.4 0.2 0.012 15.6 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 VDK76354.1 - 0.12 12.9 0.1 0.18 12.3 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain WD40_3 PF15911.5 VDK76355.1 - 8.3e-18 64.1 0.0 2.8e-17 62.5 0.0 2.0 1 0 0 1 1 1 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 VDK76355.1 - 1.2e-08 34.4 7.9 0.23 10.5 0.0 4.6 4 1 0 4 4 4 4 Coatomer WD associated region ANAPC4_WD40 PF12894.7 VDK76355.1 - 7.9e-08 32.5 1.1 0.3 11.4 0.1 5.9 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 VDK76355.1 - 0.012 15.6 22.3 10 6.5 1.1 7.9 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK76355.1 - 0.033 14.2 8.6 6.7 7.0 0.0 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat Clathrin PF00637.20 VDK76355.1 - 0.058 13.3 14.1 0.75 9.7 0.1 5.2 4 1 1 5 5 5 0 Region in Clathrin and VPS zf-ribbon_3 PF13248.6 VDK76355.1 - 0.069 12.6 13.8 3.7 7.1 5.5 3.5 3 0 0 3 3 3 0 zinc-ribbon domain FAT PF02259.23 VDK76355.1 - 0.21 10.8 1.7 2.7 7.1 0.1 2.4 2 0 0 2 2 2 0 FAT domain DZR PF12773.7 VDK76355.1 - 0.34 11.0 10.2 7.1 6.7 8.0 2.7 1 1 1 2 2 2 0 Double zinc ribbon WD40 PF00400.32 VDK76355.1 - 2.5 9.1 6.2 1.4e+02 3.6 0.0 5.1 6 0 0 6 6 5 0 WD domain, G-beta repeat Rad50_zn_hook PF04423.14 VDK76355.1 - 3.1 7.7 7.5 4.3 7.2 0.2 3.3 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-LITAF-like PF10601.9 VDK76355.1 - 8.8 6.7 9.4 5.5e+02 0.9 9.4 2.6 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain Ribosomal_S13_N PF08069.12 VDK76356.1 - 2.4e-31 107.6 0.2 5.6e-31 106.4 0.2 1.7 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 VDK76356.1 - 3.4e-15 56.0 2.1 6.1e-15 55.2 2.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 YflT PF11181.8 VDK76356.1 - 0.0045 17.5 0.0 0.0079 16.7 0.0 1.5 1 1 0 1 1 1 1 Heat induced stress protein YflT PAX PF00292.18 VDK76356.1 - 0.0093 15.9 0.2 0.018 14.9 0.1 1.7 1 1 0 1 1 1 1 'Paired box' domain BTRD1 PF17660.1 VDK76356.1 - 0.021 14.6 0.0 0.18 11.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial tandem repeat domain 1 LexA_DNA_bind PF01726.16 VDK76356.1 - 0.026 14.3 0.1 1.4 8.8 0.0 2.5 2 0 0 2 2 2 0 LexA DNA binding domain DUF3140 PF11338.8 VDK76356.1 - 0.066 13.6 0.4 0.095 13.1 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3140) zf-HC5HC2H_2 PF13832.6 VDK76361.1 - 3.9e-28 97.8 7.5 3.9e-28 97.8 7.5 3.3 3 0 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 VDK76361.1 - 6e-20 71.3 7.4 6e-20 71.3 7.4 3.6 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 VDK76361.1 - 2.7e-05 23.6 14.9 0.0028 17.2 2.1 3.5 3 0 0 3 3 3 2 PHD-finger PHD PF00628.29 VDK76361.1 - 0.51 10.3 29.0 0.063 13.2 3.1 4.0 3 0 0 3 3 3 0 PHD-finger CoaE PF01121.20 VDK76363.1 - 4.9e-56 189.2 0.1 6e-56 188.9 0.1 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 VDK76363.1 - 0.00038 21.0 0.9 0.0021 18.6 0.9 2.0 1 1 0 1 1 1 1 AAA domain NitrOD2 PF18550.1 VDK76363.1 - 0.05 13.7 0.1 0.19 11.9 0.1 1.8 1 1 1 2 2 2 0 Nitrososphaera output domain 2 CX9C PF16860.5 VDK76364.1 - 0.064 13.3 8.0 0.34 11.0 1.7 3.7 3 0 0 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, SWIRM-assoc_2 PF16496.5 VDK76380.1 - 1.1 8.1 8.6 1.6 7.5 8.6 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Sushi PF00084.20 VDK76382.1 - 5e-11 43.0 1.4 5.6e-05 23.7 0.0 2.5 2 1 0 2 2 2 2 Sushi repeat (SCR repeat) Ank_2 PF12796.7 VDK76383.1 - 1.6e-120 393.9 34.2 1.1e-17 64.4 0.1 12.7 2 2 11 14 14 14 14 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK76383.1 - 2.1e-98 321.5 50.5 6.5e-12 45.7 0.0 18.0 8 5 10 19 19 19 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK76383.1 - 2.9e-82 260.7 54.0 9.9e-05 22.5 0.0 25.9 26 0 0 26 26 26 19 Ankyrin repeat Ank_5 PF13857.6 VDK76383.1 - 3.8e-80 262.9 41.5 9.2e-11 41.8 0.1 19.3 10 4 10 20 20 20 16 Ankyrin repeats (many copies) Ank PF00023.30 VDK76383.1 - 1.2e-75 246.8 67.0 8.2e-06 26.0 0.0 24.1 25 0 0 25 25 25 16 Ankyrin repeat Cullin PF00888.22 VDK76385.1 - 6.1e-209 695.7 12.2 7.5e-209 695.4 12.2 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 VDK76385.1 - 6.5e-27 93.4 2.1 1.8e-26 91.9 2.1 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain NusB PF01029.18 VDK76385.1 - 0.0053 17.0 0.0 0.031 14.5 0.0 2.3 2 0 0 2 2 2 1 NusB family 7tm_1 PF00001.21 VDK76387.1 - 1.8e-23 83.2 9.5 4e-14 52.6 3.5 2.1 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) Cullin PF00888.22 VDK76390.1 - 1.2e-185 618.7 22.1 1.5e-185 618.4 22.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 VDK76390.1 - 5.6e-23 80.8 1.6 5.6e-23 80.8 1.6 2.2 2 0 0 2 2 2 1 Cullin protein neddylation domain TPD52 PF04201.15 VDK76392.1 - 2.1e-35 121.8 2.7 2.1e-35 121.8 2.7 1.5 2 0 0 2 2 2 1 Tumour protein D52 family Band_3_cyto PF07565.13 VDK76392.1 - 0.0013 18.6 1.2 0.0013 18.6 1.2 1.5 2 0 0 2 2 2 1 Band 3 cytoplasmic domain MADF_DNA_bdg PF10545.9 VDK76392.1 - 0.24 11.7 1.8 1.9 8.9 0.0 2.7 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like APG6_N PF17675.1 VDK76392.1 - 0.31 11.6 6.3 0.58 10.7 6.3 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region ATP19 PF11022.8 VDK76392.1 - 3.5 8.1 6.4 1.3 9.4 0.6 3.0 2 1 0 2 2 2 0 ATP synthase subunit K AAA PF00004.29 VDK76407.1 - 1.9e-14 54.2 0.1 4.2e-14 53.1 0.1 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK76407.1 - 1.1e-08 35.5 0.1 3e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 VDK76407.1 - 2.3e-08 34.6 0.4 7.5e-07 29.7 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 VDK76407.1 - 3e-06 27.3 0.4 1.2e-05 25.3 0.4 2.1 1 0 0 1 1 1 1 AAA lid domain DUF2075 PF09848.9 VDK76407.1 - 2.6e-05 23.7 0.6 0.00014 21.3 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Cdc6_C PF09079.11 VDK76407.1 - 0.00029 20.7 0.0 0.00084 19.3 0.0 1.8 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain NB-ARC PF00931.22 VDK76407.1 - 0.00068 18.9 0.0 0.0011 18.2 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.6 VDK76407.1 - 0.00086 19.7 0.3 0.0033 17.8 0.3 2.0 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 VDK76407.1 - 0.012 14.9 0.8 0.12 11.6 1.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain AAA_32 PF13654.6 VDK76407.1 - 0.037 12.8 1.7 0.38 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain HGAL PF15666.5 VDK76407.1 - 0.051 13.7 0.5 0.13 12.4 0.5 1.6 1 0 0 1 1 1 0 Germinal center-associated lymphoma AAA_30 PF13604.6 VDK76407.1 - 0.065 12.9 0.0 0.17 11.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 VDK76407.1 - 0.065 13.6 0.7 0.15 12.4 0.7 1.6 1 0 0 1 1 1 0 AAA C-terminal domain KdpD PF02702.17 VDK76407.1 - 0.07 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain AAA_11 PF13086.6 VDK76407.1 - 0.16 11.7 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA PF00004.29 VDK76408.1 - 2e-14 54.1 0.1 4.5e-14 53.0 0.1 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK76408.1 - 1.2e-08 35.3 0.1 3.2e-08 33.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 VDK76408.1 - 2.6e-08 34.4 0.4 8.1e-07 29.6 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 VDK76408.1 - 3.6e-06 27.0 0.5 1.4e-05 25.1 0.5 2.0 1 0 0 1 1 1 1 AAA lid domain DUF2075 PF09848.9 VDK76408.1 - 3.3e-05 23.3 0.6 0.00015 21.2 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Cdc6_C PF09079.11 VDK76408.1 - 0.00026 20.9 0.0 0.0009 19.2 0.0 1.9 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain NB-ARC PF00931.22 VDK76408.1 - 0.00073 18.8 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.6 VDK76408.1 - 0.00094 19.5 0.3 0.0036 17.6 0.3 2.0 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 VDK76408.1 - 0.013 14.7 0.9 0.13 11.4 0.8 2.0 1 1 1 2 2 2 0 KAP family P-loop domain AAA_32 PF13654.6 VDK76408.1 - 0.042 12.7 1.7 0.4 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain HGAL PF15666.5 VDK76408.1 - 0.061 13.4 0.2 0.16 12.1 0.2 1.7 1 0 0 1 1 1 0 Germinal center-associated lymphoma AAA_assoc_2 PF16193.5 VDK76408.1 - 0.069 13.5 0.7 0.16 12.3 0.7 1.6 1 0 0 1 1 1 0 AAA C-terminal domain AAA_30 PF13604.6 VDK76408.1 - 0.07 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain KdpD PF02702.17 VDK76408.1 - 0.071 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain AAA_11 PF13086.6 VDK76408.1 - 0.17 11.6 1.5 0.17 11.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain zf-C4 PF00105.18 VDK76409.1 - 4.8e-29 100.6 20.5 7.8e-29 99.9 20.5 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK76409.1 - 0.00052 19.6 0.1 0.0046 16.5 0.1 2.1 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Mito_fiss_reg PF05308.11 VDK76410.1 - 0.0075 16.4 6.9 0.0092 16.1 6.9 1.1 1 0 0 1 1 1 1 Mitochondrial fission regulator Pkinase PF00069.25 VDK76412.1 - 4.6e-57 193.4 0.0 1.6e-43 149.0 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK76412.1 - 4.6e-31 108.0 0.0 1.6e-24 86.6 0.0 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK76412.1 - 3.9e-05 22.6 0.0 6.8e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 VDK76412.1 - 0.0039 16.6 0.0 0.034 13.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 VDK76412.1 - 0.17 11.5 0.2 1.5 8.4 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase PF00069.25 VDK76413.1 - 6.8e-58 196.1 0.0 3e-56 190.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK76413.1 - 2.5e-26 92.5 0.0 5e-22 78.4 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 VDK76413.1 - 0.00021 21.3 0.0 0.00081 19.4 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 VDK76413.1 - 0.0044 16.0 0.2 0.0079 15.2 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 VDK76413.1 - 0.015 14.1 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 VDK76413.1 - 0.023 14.0 0.0 0.044 13.1 0.0 1.5 1 0 0 1 1 1 0 Kinase-like HNH_3 PF13392.6 VDK76414.1 - 0.02 14.6 0.1 0.032 14.0 0.1 1.3 1 0 0 1 1 1 0 HNH endonuclease G-patch PF01585.23 VDK76484.1 - 2.6e-10 40.0 0.1 5.5e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 G-patch domain Ank_2 PF12796.7 VDK76484.1 - 4.3e-10 40.1 0.0 2.5e-09 37.6 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK76484.1 - 2.4e-09 37.5 0.1 5.1e-06 26.9 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK76484.1 - 3.8e-07 30.2 0.0 1.2e-06 28.7 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK76484.1 - 7.4e-06 25.9 0.3 0.00043 20.5 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat zf-B_box PF00643.24 VDK76484.1 - 2.3e-05 24.5 4.5 2.3e-05 24.5 4.5 5.3 5 1 0 5 5 5 2 B-box zinc finger Ank PF00023.30 VDK76484.1 - 9.8e-05 22.6 0.0 0.00027 21.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat zf-RING_5 PF14634.6 VDK76484.1 - 0.00066 19.6 6.0 0.00066 19.6 6.0 4.2 3 1 0 3 3 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 VDK76484.1 - 0.0076 16.2 6.7 0.0076 16.2 6.7 2.4 2 0 0 2 2 2 1 RING-type zinc-finger FYVE_2 PF02318.16 VDK76484.1 - 0.018 15.2 1.1 0.018 15.2 1.1 4.1 3 1 1 4 4 4 0 FYVE-type zinc finger UPF0242 PF06785.11 VDK76484.1 - 0.086 12.9 1.3 0.15 12.1 1.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Nbl1_Borealin_N PF10444.9 VDK76484.1 - 1.5 8.5 4.2 5.8 6.6 0.7 3.1 2 1 1 3 3 3 0 Nbl1 / Borealin N terminal DHR-2 PF06920.13 VDK76485.1 - 3.1e-194 646.5 3.5 5.1e-194 645.8 3.5 1.3 1 0 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 VDK76485.1 - 6.6e-47 159.8 0.0 1.3e-46 158.9 0.0 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF3398 PF11878.8 VDK76485.1 - 6.3e-18 65.2 0.7 2.3e-17 63.4 0.7 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3398) PIN_8 PF18476.1 VDK76485.1 - 0.86 9.4 3.9 3.2 7.6 0.7 2.7 2 1 1 3 3 3 0 PIN like domain LRR_9 PF14580.6 VDK76486.1 - 5.9e-73 244.1 3.0 8.3e-73 243.6 3.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 VDK76486.1 - 7.6e-07 28.8 1.4 2.5e-06 27.2 0.3 2.3 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 VDK76486.1 - 0.00014 22.1 11.7 0.00045 20.6 0.7 3.2 2 1 0 3 3 3 2 Leucine Rich repeats (2 copies) CCD48 PF15799.5 VDK76486.1 - 3 6.0 5.1 2.3 6.4 0.9 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 48 DUF778 PF05608.12 VDK76487.1 - 4.5e-34 118.5 3.8 3e-21 76.7 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF778) ABC_tran PF00005.27 VDK76489.1 - 1.3e-05 25.7 0.0 3.9e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 ABC transporter NB-ARC PF00931.22 VDK76489.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain KAP_NTPase PF07693.14 VDK76489.1 - 0.012 14.8 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain AAA_29 PF13555.6 VDK76489.1 - 0.023 14.4 1.8 0.035 13.9 0.3 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 VDK76489.1 - 0.035 14.0 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_21 PF13304.6 VDK76489.1 - 0.037 13.8 0.0 0.066 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Citrus_P18 PF05520.11 VDK76489.1 - 0.062 13.0 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Citrus tristeza virus P18 protein AAA_16 PF13191.6 VDK76489.1 - 0.067 13.6 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 VDK76489.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 VDK76489.1 - 0.073 13.2 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 VDK76489.1 - 0.078 13.5 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 VDK76489.1 - 0.095 13.2 0.5 0.19 12.2 0.5 1.5 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 VDK76489.1 - 0.099 12.7 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Dynamin family AAA_14 PF13173.6 VDK76489.1 - 0.1 12.6 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK76489.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 VDK76489.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain TPT PF03151.16 VDK76491.1 - 5.3e-77 259.0 20.6 6.7e-77 258.7 20.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 VDK76491.1 - 7e-17 61.9 32.8 4e-11 43.2 7.1 2.5 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 VDK76491.1 - 0.17 11.1 17.5 0.25 10.5 17.5 1.3 1 0 0 1 1 1 0 UAA transporter family Sod_Cu PF00080.20 VDK76493.1 - 9.3e-50 168.5 4.0 1.1e-49 168.3 4.0 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Sod_Cu PF00080.20 VDK76495.1 - 2.4e-47 160.7 1.0 2.9e-47 160.4 1.0 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) C_tripleX PF02363.19 VDK76496.1 - 0.0092 16.2 18.0 0.015 15.5 4.5 9.1 7 1 1 8 8 8 4 Cysteine rich repeat COX16 PF14138.6 VDK76498.1 - 0.0096 16.4 0.8 0.016 15.7 0.8 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 CybS PF05328.12 VDK76498.1 - 0.01 15.5 0.0 0.038 13.7 0.0 1.9 1 1 2 3 3 3 0 CybS, succinate dehydrogenase cytochrome B small subunit Oleosin PF01277.17 VDK76498.1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Oleosin LapA_dom PF06305.11 VDK76498.1 - 0.12 12.2 0.9 0.25 11.2 0.8 1.6 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Fmp27 PF10344.9 VDK76498.1 - 0.3 9.1 2.0 0.34 8.9 2.0 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 TCR PF03638.15 VDK76499.1 - 1.8e-22 79.3 57.6 2.6e-11 43.6 20.8 2.3 2 0 0 2 2 2 2 Tesmin/TSO1-like CXC domain, cysteine-rich domain MSL2-CXC PF16682.5 VDK76499.1 - 0.00048 20.2 44.7 0.053 13.7 14.4 2.6 2 0 0 2 2 2 2 CXC domain of E3 ubiquitin-protein ligase MSL2 FAA_hydrolase PF01557.18 VDK76514.1 - 2.5e-56 190.8 0.0 3.2e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Sina PF03145.16 VDK76515.1 - 2.5e-78 262.6 0.7 3.9e-78 262.0 0.7 1.3 1 0 0 1 1 1 1 Seven in absentia protein family RabGAP-TBC PF00566.18 VDK76516.1 - 6.5e-34 117.5 3.3 5.2e-30 104.7 0.9 2.4 2 1 0 2 2 2 2 Rab-GTPase-TBC domain CENP-T_C PF15511.6 VDK76518.1 - 1.2e-08 35.0 0.1 1.5e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 VDK76518.1 - 1.7e-05 25.1 0.1 2.3e-05 24.7 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 VDK76518.1 - 4.3e-05 23.7 0.1 6.6e-05 23.1 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 VDK76518.1 - 4.4e-05 23.6 0.1 6e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 VDK76518.1 - 6.4e-05 23.3 0.2 7.4e-05 23.1 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 VDK76518.1 - 0.0049 16.8 0.1 0.0075 16.3 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 VDK76518.1 - 0.0074 16.4 0.0 0.0086 16.1 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit eIF-1a PF01176.19 VDK76520.1 - 2e-21 75.6 0.0 2.9e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 DNA_pol_phi PF04931.13 VDK76520.1 - 4.1 5.4 12.3 5.3 5.0 12.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 VDK76520.1 - 6 5.0 10.5 6.6 4.8 10.5 1.1 1 0 0 1 1 1 0 Nop14-like family G-patch_2 PF12656.7 VDK76521.1 - 1.7e-18 66.4 0.0 4.9e-18 65.0 0.0 1.8 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 VDK76521.1 - 1.4e-05 24.9 0.3 3.5e-05 23.6 0.3 1.7 1 0 0 1 1 1 1 G-patch domain KOW PF00467.29 VDK76521.1 - 9.2e-05 22.3 1.1 0.044 13.7 0.0 2.9 3 0 0 3 3 3 2 KOW motif KN17_SH3 PF18131.1 VDK76521.1 - 0.0012 18.9 0.1 0.0067 16.5 0.0 2.3 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain IPTL-CTERM PF18203.1 VDK76522.1 - 0.16 11.9 0.3 0.34 10.9 0.3 1.5 1 0 0 1 1 1 0 IPTL-CTERM motif DUF2650 PF10853.8 VDK76524.1 - 4.5e-15 55.1 8.5 9.1e-15 54.1 8.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2650) zf-AD PF07776.15 VDK76529.1 - 0.016 15.5 0.2 0.021 15.1 0.2 1.1 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) zf-HYPF PF07503.12 VDK76529.1 - 0.12 12.1 0.1 0.17 11.7 0.1 1.1 1 0 0 1 1 1 0 HypF finger Pyr_redox_3 PF13738.6 VDK76530.1 - 8.3e-10 38.4 0.0 1.8e-08 34.0 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 VDK76530.1 - 5.3e-07 29.1 0.0 6.2e-06 25.6 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 VDK76530.1 - 6.5e-06 25.6 0.1 0.0047 16.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 VDK76530.1 - 0.037 13.3 0.1 0.076 12.3 0.1 1.5 2 0 0 2 2 2 0 FAD binding domain Elongin_A PF06881.11 VDK76533.1 - 0.0047 17.4 0.0 0.0087 16.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A TruD PF01142.18 VDK76534.1 - 2.1e-71 240.9 0.0 1.2e-67 228.5 0.0 3.1 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) TBCC PF07986.12 VDK76536.1 - 4.7e-41 139.3 6.8 7.5e-41 138.6 6.8 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 VDK76536.1 - 0.027 14.1 1.3 0.047 13.3 1.3 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) C terminal DUF5041 PF16444.5 VDK76537.1 - 0.0048 17.2 0.2 0.0077 16.5 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5041) Thioredoxin PF00085.20 VDK76539.1 - 1.7e-05 24.7 0.0 3.1e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 VDK76539.1 - 0.1 13.0 0.0 1.6 9.2 0.0 2.3 1 1 0 1 1 1 0 Thioredoxin-like domain HyaE PF07449.11 VDK76539.1 - 0.15 12.1 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Tyrosinase PF00264.20 VDK76560.1 - 1.2e-30 107.5 0.6 2.9e-30 106.2 0.6 1.6 1 1 0 1 1 1 1 Common central domain of tyrosinase Ge1_WD40 PF16529.5 VDK76560.1 - 0.019 14.0 0.0 0.027 13.5 0.0 1.1 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Tyrosinase PF00264.20 VDK76562.1 - 3e-33 116.0 0.5 1.1e-32 114.2 0.4 2.0 1 1 0 1 1 1 1 Common central domain of tyrosinase ShK PF01549.24 VDK76562.1 - 8.3e-16 58.2 29.3 2.1e-08 34.5 9.2 3.3 2 0 0 2 2 2 2 ShK domain-like TIL PF01826.17 VDK76563.1 - 2e-36 124.0 108.8 1.1e-12 48.0 19.4 5.2 5 0 0 5 5 5 4 Trypsin Inhibitor like cysteine rich domain DUF1075 PF06388.11 VDK76563.1 - 0.029 14.4 0.0 0.067 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) Pkinase PF00069.25 VDK76564.1 - 8.8e-40 136.7 0.0 2e-39 135.6 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK76564.1 - 5e-22 78.4 0.0 9.4e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase UNC45-central PF11701.8 VDK76564.1 - 0.023 14.7 1.2 0.061 13.3 1.2 1.7 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central Peptidase_S24 PF00717.23 VDK76565.1 - 1.5e-05 24.8 0.5 7.9e-05 22.5 0.5 2.1 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_C2 PF00648.21 VDK76567.1 - 1.7e-126 421.3 0.0 1.7e-126 421.3 0.0 1.3 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.22 VDK76567.1 - 1.4e-43 148.6 0.0 2.8e-43 147.6 0.0 1.5 1 0 0 1 1 1 1 Calpain large subunit, domain III IMS_C PF11799.8 VDK76571.1 - 0.0057 17.3 0.0 0.011 16.4 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain ubiquitin PF00240.23 VDK76571.1 - 0.077 12.8 0.4 16 5.3 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin family IMS PF00817.20 VDK76572.1 - 1.7e-44 151.5 0.1 2.4e-44 150.9 0.1 1.2 1 0 0 1 1 1 1 impB/mucB/samB family Na_Ala_symp PF01235.17 VDK76572.1 - 0.15 11.3 0.1 7.2 5.8 0.1 2.1 2 0 0 2 2 2 0 Sodium:alanine symporter family Hus1 PF04005.12 VDK76573.1 - 2.9e-31 108.7 0.0 4.1e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Hus1-like protein Rad51 PF08423.11 VDK76573.1 - 4.8e-24 85.0 0.5 6.4e-24 84.6 0.5 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 VDK76573.1 - 4.4e-07 29.7 0.0 7.5e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 VDK76573.1 - 4.7e-06 26.1 0.6 1.7e-05 24.3 0.6 1.9 1 1 0 1 1 1 1 KaiC RecA PF00154.21 VDK76573.1 - 5.2e-05 22.8 0.5 0.00032 20.3 0.5 2.0 1 1 0 1 1 1 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 VDK76573.1 - 0.00012 21.5 0.7 0.0056 16.0 0.2 2.2 1 1 1 2 2 2 1 DnaB-like helicase C terminal domain DUF4097 PF13349.6 VDK76573.1 - 0.011 15.1 0.0 0.02 14.3 0.0 1.5 1 1 0 1 1 1 0 Putative adhesin AAA_33 PF13671.6 VDK76573.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain EF-hand_7 PF13499.6 VDK76574.1 - 1.1e-11 45.0 0.1 0.00018 21.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK76574.1 - 1.1e-10 40.2 0.3 0.00017 20.9 0.0 4.5 4 1 1 5 5 5 2 EF hand EF-hand_6 PF13405.6 VDK76574.1 - 8e-10 37.9 0.1 0.0011 18.7 0.1 3.8 5 0 0 5 5 5 2 EF-hand domain EF-hand_8 PF13833.6 VDK76574.1 - 3.2e-07 30.1 0.3 0.087 12.7 0.0 3.6 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 VDK76574.1 - 3.4e-07 30.5 0.0 0.0021 18.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 VDK76574.1 - 0.051 13.6 0.0 9.5 6.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) TFIID-31kDa PF02291.15 VDK76575.1 - 2.2e-40 137.5 0.0 2.9e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 VDK76575.1 - 0.00022 21.5 0.1 0.0004 20.7 0.1 1.4 1 0 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.13 VDK76575.1 - 0.00032 20.7 0.0 0.00051 20.0 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 VDK76575.1 - 0.0016 18.5 0.0 0.0028 17.7 0.0 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 VDK76575.1 - 0.0059 17.0 0.9 0.009 16.4 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 SGS PF05002.15 VDK76576.1 - 1.3e-30 105.3 5.2 2.4e-30 104.5 5.2 1.4 1 1 0 1 1 1 1 SGS domain CS PF04969.16 VDK76576.1 - 7.5e-06 26.9 0.0 1.6e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 CS domain Proteasome PF00227.26 VDK76577.1 - 5.3e-56 189.1 0.0 6.9e-56 188.7 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 VDK76577.1 - 1.2e-06 28.1 0.0 2e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Snf7 PF03357.21 VDK76590.1 - 2.8e-15 56.4 19.2 2.8e-15 56.4 19.2 1.3 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 VDK76590.1 - 0.00035 20.5 8.0 0.00047 20.1 8.0 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway DUF3447 PF11929.8 VDK76590.1 - 0.023 14.7 0.1 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) DUF1351 PF07083.11 VDK76590.1 - 0.066 13.0 12.0 2.4 7.9 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1351) DUF3708 PF12501.8 VDK76590.1 - 0.45 10.3 4.7 0.33 10.7 2.9 1.5 1 1 0 1 1 1 0 Phosphate ATP-binding cassette transporter YlbD_coat PF14071.6 VDK76590.1 - 4.4 7.6 10.7 0.96 9.7 1.1 2.2 1 1 1 2 2 2 0 Putative coat protein Zip PF02535.22 VDK76593.1 - 4.3e-32 111.7 0.8 6e-32 111.2 0.8 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter UQ_con PF00179.26 VDK76596.1 - 2e-53 179.8 0.0 2.3e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK76596.1 - 0.016 14.9 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 VDK76596.1 - 0.02 15.2 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 VDK76596.1 - 0.058 13.3 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 UEV domain ribosomal_L24 PF17136.4 VDK76599.1 - 7.9e-07 29.4 0.0 2e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 VDK76599.1 - 2.6e-06 27.2 3.3 2.8e-06 27.1 1.7 1.9 2 0 0 2 2 2 1 KOW motif AAA PF00004.29 VDK76605.1 - 3.4e-42 144.0 0.0 9e-42 142.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 VDK76605.1 - 3.6e-19 68.5 0.5 8.4e-19 67.3 0.5 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 VDK76605.1 - 1.7e-10 40.5 0.6 3.9e-10 39.4 0.6 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 VDK76605.1 - 9e-07 29.0 2.6 2.2e-06 27.7 0.1 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 VDK76605.1 - 7.1e-06 26.5 0.3 0.0037 17.7 0.0 2.7 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 VDK76605.1 - 1.2e-05 25.1 0.0 4e-05 23.4 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 VDK76605.1 - 2.8e-05 24.3 0.0 0.00017 21.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 VDK76605.1 - 0.00027 21.2 2.7 0.0097 16.2 0.0 3.1 2 1 1 3 3 3 1 AAA domain DUF815 PF05673.13 VDK76605.1 - 0.0013 17.9 0.0 0.0024 17.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 VDK76605.1 - 0.0018 17.7 0.1 0.0054 16.1 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 VDK76605.1 - 0.0073 16.9 0.0 0.026 15.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 VDK76605.1 - 0.0093 15.5 0.0 0.024 14.2 0.0 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 VDK76605.1 - 0.012 15.8 0.0 0.04 14.1 0.0 2.0 2 0 0 2 2 1 0 AAA domain ATPase PF06745.13 VDK76605.1 - 0.012 14.9 1.3 0.067 12.5 0.0 2.4 2 0 0 2 2 2 0 KaiC IstB_IS21 PF01695.17 VDK76605.1 - 0.014 15.1 0.0 0.032 14.0 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 VDK76605.1 - 0.015 15.0 0.2 0.048 13.4 0.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 VDK76605.1 - 0.017 14.7 0.5 0.1 12.1 0.1 2.3 1 1 1 2 2 2 0 AAA domain AAA_3 PF07726.11 VDK76605.1 - 0.025 14.4 0.1 0.33 10.8 0.0 2.7 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 VDK76605.1 - 0.027 13.9 0.0 0.098 12.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein CPT PF07931.12 VDK76605.1 - 0.039 13.8 0.0 0.084 12.7 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein RNA_helicase PF00910.22 VDK76605.1 - 0.045 14.1 0.0 0.099 13.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 VDK76605.1 - 0.057 13.1 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 VDK76605.1 - 0.066 13.1 0.6 0.31 10.9 0.1 2.2 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 VDK76605.1 - 0.085 12.6 0.1 0.23 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 VDK76605.1 - 0.09 11.8 0.2 0.2 10.7 0.0 1.6 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 VDK76605.1 - 0.095 12.7 0.2 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 VDK76605.1 - 0.12 12.7 1.3 0.23 11.8 0.2 2.1 2 1 0 2 2 1 0 AAA domain TsaE PF02367.17 VDK76605.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Prot_ATP_OB_N PF17758.1 VDK76605.1 - 0.14 11.8 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain ABC_tran PF00005.27 VDK76605.1 - 0.15 12.6 0.2 1.4 9.4 0.0 2.4 2 1 0 2 2 2 0 ABC transporter ATPase_2 PF01637.18 VDK76605.1 - 0.22 11.4 1.6 7.9 6.3 0.0 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea DUF812 PF05667.11 VDK76605.1 - 0.27 10.1 6.1 0.4 9.5 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) AAA_11 PF13086.6 VDK76605.1 - 0.28 10.9 4.7 0.31 10.8 0.1 2.3 2 1 0 2 2 2 0 AAA domain Mito_carr PF00153.27 VDK76606.1 - 4.8e-34 116.1 3.2 3.2e-14 52.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L13 PF00572.18 VDK76607.1 - 2.2e-35 121.6 0.0 3e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 Ret2_MD PF18528.1 VDK76609.1 - 0.065 13.6 0.0 0.12 12.8 0.0 1.6 2 0 0 2 2 2 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Frataxin_Cyay PF01491.16 VDK76611.1 - 5e-32 110.2 0.1 6.8e-32 109.8 0.1 1.2 1 0 0 1 1 1 1 Frataxin-like domain ADH_zinc_N_2 PF13602.6 VDK76612.1 - 1.6e-11 45.3 0.0 3.2e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 VDK76612.1 - 1.2e-07 31.5 0.1 3.7e-07 30.0 0.1 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 VDK76612.1 - 4.2e-07 30.0 0.0 8.7e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 VDK76612.1 - 0.0042 16.6 0.0 0.0058 16.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 VDK76612.1 - 0.0067 16.7 0.0 0.021 15.1 0.0 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_3 PF03447.16 VDK76612.1 - 0.15 12.7 0.0 0.34 11.6 0.0 1.6 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 VDK76612.1 - 0.16 12.0 0.0 0.37 10.9 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.17 VDK76612.1 - 0.19 10.8 0.0 0.34 10.0 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Glyco_hydro_2_C PF02836.17 VDK76613.1 - 8.6e-68 228.7 0.0 2.7e-67 227.0 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 VDK76613.1 - 2.7e-19 69.7 1.0 6.7e-19 68.4 1.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 VDK76613.1 - 7e-07 29.9 0.0 1.4e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 PRCC PF10253.9 VDK76640.1 - 1.8e-21 78.0 7.3 4.9e-20 73.2 6.9 2.3 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting AcylCoA_DH_N PF12418.8 VDK76640.1 - 0.12 12.4 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase N terminal Copper-fist PF00649.18 VDK76642.1 - 0.069 12.7 0.2 0.17 11.4 0.2 1.6 1 0 0 1 1 1 0 Copper fist DNA binding domain Glyco_transf_49 PF13896.6 VDK76643.1 - 1.5e-35 123.1 1.6 6.4e-13 48.8 0.1 3.2 1 1 2 3 3 3 3 Glycosyl-transferase for dystroglycan Claudin_2 PF13903.6 VDK76644.1 - 7.2e-09 35.7 0.1 1.1e-08 35.1 0.1 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 VDK76644.1 - 0.0012 18.7 1.6 0.0016 18.3 0.7 1.6 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Neur_chan_memb PF02932.16 VDK76646.1 - 7.5e-21 75.3 3.1 7.5e-21 75.3 3.1 2.6 2 1 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 VDK76646.1 - 3.7e-20 72.3 0.1 6.2e-20 71.6 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Lectin_C PF00059.21 VDK76646.1 - 1.9e-13 51.1 0.2 4.8e-13 49.8 0.2 1.7 1 0 0 1 1 1 1 Lectin C-type domain EB PF01683.18 VDK76646.1 - 0.0077 16.5 5.9 0.017 15.4 5.9 1.6 1 0 0 1 1 1 1 EB module Drf_FH1 PF06346.12 VDK76646.1 - 0.033 13.9 55.3 0.08 12.7 22.0 3.1 1 1 2 3 3 3 0 Formin Homology Region 1 Robl_LC7 PF03259.17 VDK76646.1 - 0.049 13.4 0.0 0.093 12.5 0.0 1.4 1 0 0 1 1 1 0 Roadblock/LC7 domain Hint PF01079.20 VDK76647.1 - 1.8e-47 161.7 0.0 2.9e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Hint module Hint_2 PF13403.6 VDK76647.1 - 0.0032 17.8 0.0 0.0065 16.8 0.0 1.6 1 0 0 1 1 1 1 Hint domain Intein_splicing PF14890.6 VDK76647.1 - 0.031 14.2 0.1 0.15 12.0 0.1 2.0 2 0 0 2 2 2 0 Intein splicing domain UQ_con PF00179.26 VDK76648.1 - 8.2e-47 158.4 0.0 9.5e-47 158.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK76648.1 - 5.3e-05 22.9 0.0 6.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Ets PF00178.22 VDK76651.1 - 2.3e-31 108.1 4.5 1.3e-30 105.7 3.0 2.4 2 0 0 2 2 2 1 Ets-domain SAM_PNT PF02198.16 VDK76651.1 - 1.3e-14 53.9 0.1 2.6e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SWI-SNF_Ssr4 PF08549.10 VDK76651.1 - 0.011 14.4 3.4 0.015 13.9 3.4 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF3540 PF12059.8 VDK76651.1 - 0.086 12.7 1.2 0.16 11.8 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) RIFIN PF02009.16 VDK76651.1 - 0.87 9.4 5.8 1.7 8.5 5.8 1.4 1 0 0 1 1 1 0 Rifin Mucin PF01456.17 VDK76651.1 - 7 6.6 65.4 0.031 14.3 52.2 2.8 2 1 0 2 2 2 0 Mucin-like glycoprotein FlaG PF03646.15 VDK76671.1 - 0.025 14.7 1.3 0.033 14.4 1.3 1.2 1 0 0 1 1 1 0 FlaG protein DAG1 PF05454.11 VDK76672.1 - 9.8e-18 64.5 16.4 3.3e-17 62.8 0.3 2.4 1 1 1 2 2 2 2 Dystroglycan (Dystrophin-associated glycoprotein 1) HTH_7 PF02796.15 VDK76672.1 - 0.04 14.0 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Mito_carr PF00153.27 VDK76673.1 - 5.6e-58 192.9 1.1 1.9e-18 66.1 0.5 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein TraB PF01963.17 VDK76674.1 - 9.4e-25 88.0 0.1 1.6e-24 87.3 0.1 1.2 1 0 0 1 1 1 1 TraB family ELO PF01151.18 VDK76675.1 - 4.3e-55 187.0 26.6 5.5e-55 186.6 26.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family ELO PF01151.18 VDK76676.1 - 1.9e-51 175.0 26.2 2.4e-51 174.7 26.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PBP PF01161.20 VDK76677.1 - 1.3e-17 64.3 0.0 1.7e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein LSM PF01423.22 VDK76678.1 - 8.9e-11 41.3 0.0 1.3e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain DUF1084 PF06454.11 VDK76678.1 - 0.064 12.6 0.2 0.088 12.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1084) JmjC PF02373.22 VDK76679.1 - 1.1e-39 135.3 2.3 2.7e-39 134.1 2.3 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase PLU-1 PF08429.11 VDK76679.1 - 1.7e-30 106.3 9.1 3e-30 105.6 9.1 1.4 1 0 0 1 1 1 1 PLU-1-like protein PHD PF00628.29 VDK76679.1 - 2.9e-15 55.9 44.9 2.9e-08 33.4 10.9 4.3 4 0 0 4 4 4 3 PHD-finger JmjN PF02375.17 VDK76679.1 - 3.5e-13 49.3 3.7 1.3e-12 47.4 3.7 2.1 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 VDK76679.1 - 9.3e-13 48.4 9.3 9.3e-13 48.4 9.3 2.9 2 0 0 2 2 2 1 C5HC2 zinc finger ARID PF01388.21 VDK76679.1 - 9.5e-12 45.4 0.4 2.6e-11 44.0 0.4 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PIN_4 PF13638.6 VDK76683.1 - 5.3e-21 75.3 0.0 8.5e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 PIN domain Astacin PF01400.24 VDK76684.1 - 3.6e-64 215.9 0.0 5.9e-64 215.2 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 VDK76684.1 - 6.4e-14 52.2 21.5 6.1e-08 33.1 5.3 2.6 2 0 0 2 2 2 2 ShK domain-like Atg8 PF02991.16 VDK76685.1 - 4.5e-41 139.3 0.1 5.2e-41 139.0 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 VDK76685.1 - 8.6e-06 26.1 0.0 1.1e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Fic PF02661.18 VDK76687.1 - 9.1e-25 87.4 0.1 2.8e-24 85.9 0.0 1.9 2 1 0 2 2 2 1 Fic/DOC family TPR_19 PF14559.6 VDK76687.1 - 0.00031 21.2 0.6 0.024 15.1 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK76687.1 - 0.00092 19.2 1.3 0.56 10.4 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK76687.1 - 0.0015 18.3 0.0 0.24 11.3 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK76687.1 - 0.0015 19.2 2.8 1.7 9.7 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 VDK76687.1 - 0.0047 17.1 0.2 0.047 13.8 0.2 2.4 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK76687.1 - 0.0093 16.6 1.9 0.48 11.1 0.2 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK76687.1 - 0.04 14.2 0.4 0.17 12.2 0.4 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK76687.1 - 0.16 12.3 0.0 20 5.7 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat Alpha-amylase PF00128.24 VDK76689.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Alpha amylase, catalytic domain ArfGap PF01412.18 VDK76715.1 - 1.2e-23 83.4 0.0 3.5e-23 81.9 0.0 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf SH3_9 PF14604.6 VDK76715.1 - 4.9e-09 35.9 0.0 1.1e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 VDK76715.1 - 3.5e-07 30.7 0.3 1e-06 29.2 0.3 1.9 1 0 0 1 1 1 1 PH domain SH3_2 PF07653.17 VDK76715.1 - 6.2e-07 29.0 0.0 1.9e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK76715.1 - 4.9e-06 26.1 0.0 9.3e-06 25.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.5 VDK76715.1 - 0.00068 19.4 2.0 0.0012 18.6 2.0 1.4 1 0 0 1 1 1 1 BAR domain of APPL family Med10 PF09748.9 VDK76715.1 - 0.035 14.1 2.6 0.069 13.1 0.4 2.6 2 1 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex DNA_pol_B_exo1 PF03104.19 VDK76717.1 - 1.4e-13 50.7 1.2 2.4e-13 49.9 1.2 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 VDK76718.1 - 2.9e-97 326.2 0.0 3.7e-97 325.9 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 VDK76718.1 - 4.2e-09 36.0 0.0 7e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 VDK76718.1 - 0.046 14.2 8.9 0.11 13.0 8.9 1.7 1 0 0 1 1 1 0 C4-type zinc-finger of DNA polymerase delta Peptidase_C74 PF12387.8 VDK76718.1 - 0.089 12.3 0.0 0.28 10.6 0.0 1.8 1 1 0 1 1 1 0 Pestivirus NS2 peptidase Helicase_C PF00271.31 VDK76720.1 - 7.9e-08 32.6 0.1 2.5e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK76720.1 - 9.6e-06 25.5 0.2 2.7e-05 24.0 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Trimer_CC PF08954.11 VDK76723.1 - 0.11 12.1 0.1 0.33 10.6 0.1 1.8 1 0 0 1 1 1 0 Trimerisation motif Voltage_CLC PF00654.20 VDK76725.1 - 2.1e-95 320.0 22.4 2.1e-95 320.0 22.4 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 VDK76725.1 - 2e-15 57.0 0.8 1.9e-07 31.4 0.0 2.9 2 0 0 2 2 2 2 CBS domain tRNA-synt_2b PF00587.25 VDK76727.1 - 6.3e-35 120.8 0.0 1.1e-34 119.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 VDK76727.1 - 1.1e-17 64.0 0.6 2.3e-17 62.9 0.6 1.5 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 VDK76727.1 - 6.1e-16 58.2 0.0 1.5e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 VDK76727.1 - 4.5e-11 42.7 0.0 1.1e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain HRG PF16954.5 VDK76728.1 - 1.9e-11 44.1 7.8 1.9e-11 44.1 7.8 2.9 3 1 0 3 3 3 1 Haem-transporter, endosomal/lysosomal, haem-responsive gene CobS PF02654.15 VDK76728.1 - 5.4 7.1 10.4 0.4 10.8 2.0 2.1 1 1 1 2 2 2 0 Cobalamin-5-phosphate synthase Patatin PF01734.22 VDK76730.1 - 1e-16 61.8 3.8 1.3e-16 61.4 1.4 2.3 2 1 0 2 2 2 1 Patatin-like phospholipase ARID PF01388.21 VDK76743.1 - 1.7e-16 60.7 0.1 3.1e-16 59.8 0.1 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain GREB1 PF15782.5 VDK76743.1 - 0.015 12.5 0.4 0.02 12.0 0.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HTH_51 PF18558.1 VDK76743.1 - 0.13 12.1 1.1 4.7 7.2 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain Macoilin PF09726.9 VDK76743.1 - 1.7 7.1 6.2 2.1 6.8 6.2 1.1 1 0 0 1 1 1 0 Macoilin family RhlB PF12300.8 VDK76743.1 - 3.9 7.6 16.1 0.25 11.5 8.3 2.3 1 1 0 2 2 2 0 ATP-dependent RNA helicase RhlB CNDH2_C PF16858.5 VDK76744.1 - 0.061 13.2 0.3 0.072 13.0 0.3 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Med23 PF11573.8 VDK76747.1 - 1.3e-208 695.7 35.0 3.9e-200 667.6 27.0 2.4 2 1 1 3 3 3 2 Mediator complex subunit 23 Neur_chan_memb PF02932.16 VDK76747.1 - 2.2e-66 224.3 0.2 4.2e-66 223.4 0.2 1.5 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 VDK76747.1 - 2.4e-29 102.3 0.8 1.3e-26 93.4 0.8 3.4 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain MnmE_helical PF12631.7 VDK76747.1 - 2.5e-28 99.7 4.2 3.7e-28 99.1 0.5 2.6 2 0 0 2 2 2 1 MnmE helical domain MMR_HSR1 PF01926.23 VDK76747.1 - 3.4e-22 78.7 0.1 9.8e-22 77.2 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase TrmE_N PF10396.9 VDK76747.1 - 4.8e-20 72.0 0.0 1.3e-19 70.6 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus FeoB_N PF02421.18 VDK76747.1 - 5.3e-11 42.3 0.1 3.5e-10 39.6 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B SH2 PF00017.24 VDK76747.1 - 7.9e-11 41.9 0.1 3.1e-09 36.8 0.0 2.7 2 0 0 2 2 2 1 SH2 domain RsgA_GTPase PF03193.16 VDK76747.1 - 7.2e-05 22.7 0.2 0.00056 19.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase SOCS_box PF07525.16 VDK76747.1 - 0.00012 22.4 3.7 0.00012 22.4 3.7 2.4 2 0 0 2 2 2 1 SOCS box Ras PF00071.22 VDK76747.1 - 0.00018 21.1 0.0 0.00041 20.0 0.0 1.6 1 0 0 1 1 1 1 Ras family AIG1 PF04548.16 VDK76747.1 - 0.00026 20.4 0.4 0.00053 19.4 0.4 1.5 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 VDK76747.1 - 0.00037 20.1 0.4 0.04 13.5 0.3 3.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 VDK76747.1 - 0.0004 20.6 0.0 0.002 18.3 0.0 2.3 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 VDK76747.1 - 0.00082 19.5 0.8 0.051 13.6 0.0 3.2 2 1 1 3 3 3 1 Dynamin family ABC_tran PF00005.27 VDK76747.1 - 0.22 12.0 0.2 2.8 8.4 0.0 2.8 3 0 0 3 3 3 0 ABC transporter AAA_13 PF13166.6 VDK76748.1 - 0.0032 16.2 19.5 0.0032 16.2 19.5 5.0 3 2 2 5 5 5 2 AAA domain TMF_DNA_bd PF12329.8 VDK76748.1 - 0.0035 17.3 0.7 0.0035 17.3 0.7 11.2 7 3 3 10 10 10 2 TATA element modulatory factor 1 DNA binding PAS_11 PF14598.6 VDK76749.1 - 1.3e-23 83.3 0.7 9.6e-19 67.6 0.1 2.7 3 0 0 3 3 3 2 PAS domain HLH PF00010.26 VDK76749.1 - 3.3e-14 52.6 1.5 5.7e-14 51.8 1.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS_3 PF08447.12 VDK76749.1 - 6e-09 36.1 0.1 0.0041 17.4 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 VDK76749.1 - 6.5e-09 35.8 0.1 1.1e-06 28.6 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 VDK76749.1 - 0.00012 22.3 0.0 0.23 11.7 0.0 2.6 2 1 0 2 2 2 2 PAS domain PAS_4 PF08448.10 VDK76749.1 - 0.0087 16.3 0.1 3.2 8.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold Ank_2 PF12796.7 VDK76786.1 - 7.3e-08 32.9 0.1 1.1e-07 32.3 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK76786.1 - 0.0011 19.5 0.1 0.0025 18.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK76786.1 - 0.0047 17.3 0.1 0.32 11.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat GIT_SHD PF08518.11 VDK76786.1 - 0.089 12.4 0.1 0.089 12.4 0.1 2.0 3 0 0 3 3 3 0 Spa2 homology domain (SHD) of GIT Ank PF00023.30 VDK76786.1 - 0.11 12.9 0.2 15 6.3 0.1 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ras PF00071.22 VDK76787.1 - 1.7e-52 177.3 0.0 2e-52 177.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK76787.1 - 3.4e-20 72.4 0.0 4.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK76787.1 - 5.1e-10 39.1 0.0 6.7e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK76787.1 - 2.1e-05 24.5 1.8 0.035 14.0 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 VDK76787.1 - 0.0001 21.9 0.2 0.00036 20.1 0.0 1.8 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDK76787.1 - 0.00023 21.2 0.0 0.00036 20.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 VDK76787.1 - 0.00024 21.0 0.9 0.0023 17.8 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 VDK76787.1 - 0.0012 18.4 0.0 0.0021 17.6 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B G-alpha PF00503.20 VDK76787.1 - 0.0016 17.6 0.0 0.14 11.3 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 VDK76787.1 - 0.02 14.2 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 VDK76787.1 - 0.081 13.3 0.1 0.11 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 VDK76787.1 - 0.15 11.7 0.4 0.77 9.5 0.1 2.0 1 1 0 2 2 2 0 AAA domain ANAPC5 PF12862.7 VDK76788.1 - 4e-10 39.6 12.9 8.4e-10 38.6 0.9 4.6 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 5 TPR_MalT PF17874.1 VDK76788.1 - 7.7e-07 28.8 6.1 7.7e-07 28.8 6.1 2.5 2 1 0 2 2 2 1 MalT-like TPR region TPR_21 PF09976.9 VDK76788.1 - 0.0015 18.3 0.7 1.4 8.6 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 VDK76788.1 - 0.0016 18.7 2.2 16 5.8 0.1 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK76788.1 - 0.0073 16.3 0.5 9.4 6.6 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat CLTH PF10607.9 VDK76788.1 - 0.083 12.8 1.3 1.4 8.8 1.3 2.7 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain BAR_2 PF10455.9 VDK76788.1 - 0.1 11.7 1.6 4 6.5 0.1 2.6 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking ANAPC3 PF12895.7 VDK76788.1 - 0.1 12.8 3.5 17 5.7 0.7 3.5 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 VDK76788.1 - 0.15 12.9 3.6 34 5.6 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Gelsolin PF00626.22 VDK76796.1 - 2.2e-64 213.3 6.0 5.5e-14 51.8 0.0 6.6 6 1 0 6 6 6 5 Gelsolin repeat LRR_8 PF13855.6 VDK76796.1 - 8.3e-42 140.8 45.1 3e-08 33.3 10.9 7.4 5 2 2 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 VDK76796.1 - 2.2e-28 97.8 51.3 9.8e-05 22.7 1.3 8.5 6 1 3 9 9 9 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK76796.1 - 8e-06 25.7 43.1 7.4 7.6 0.1 12.7 14 0 0 14 14 14 5 Leucine Rich Repeat LRR_5 PF13306.6 VDK76796.1 - 0.16 11.9 0.4 12 5.9 0.1 2.4 2 0 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) TAP_C PF03943.13 VDK76797.1 - 3.8e-18 64.8 0.3 6.6e-18 64.1 0.3 1.4 1 0 0 1 1 1 1 TAP C-terminal domain Tap-RNA_bind PF09162.10 VDK76797.1 - 2.3e-10 40.2 0.0 5.4e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 Tap, RNA-binding NTF2 PF02136.20 VDK76797.1 - 0.0009 19.8 0.0 0.0028 18.2 0.0 1.9 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.7 VDK76797.1 - 0.0089 16.4 1.1 0.017 15.5 0.1 2.0 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) Phage_holin_2_2 PF10746.9 VDK76797.1 - 0.048 13.3 0.1 0.098 12.3 0.1 1.5 1 0 0 1 1 1 0 Phage holin T7 family, holin superfamily II HLH PF00010.26 VDK76798.1 - 5.3e-12 45.5 0.1 1.3e-11 44.3 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain BLOC1_2 PF10046.9 VDK76798.1 - 0.074 13.4 0.6 0.18 12.1 0.6 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Helicase_C PF00271.31 VDK76799.1 - 4.5e-20 72.0 2.7 3.8e-19 69.1 0.6 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RIG-I_C-RD PF11648.8 VDK76799.1 - 1.5e-19 70.3 1.7 4.1e-19 68.9 1.7 1.8 1 0 0 1 1 1 1 C-terminal domain of RIG-I DEAD PF00270.29 VDK76799.1 - 2.2e-17 63.4 0.2 2.5e-14 53.4 0.0 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 VDK76799.1 - 9.2e-17 61.6 0.1 1.6e-15 57.5 0.0 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 VDK76799.1 - 0.0086 16.4 0.1 0.094 13.0 0.0 2.8 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 VDK76799.1 - 0.016 14.7 0.2 0.042 13.3 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA PF00004.29 VDK76799.1 - 0.017 15.5 0.0 0.2 12.1 0.0 2.8 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 VDK76799.1 - 0.032 14.0 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 VDK76799.1 - 0.033 13.7 0.1 0.074 12.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 VDK76799.1 - 0.034 13.9 0.0 0.096 12.4 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain Yippee-Mis18 PF03226.14 VDK76799.1 - 0.04 14.1 2.5 0.11 12.7 2.5 1.7 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ATP-synt_ab PF00006.25 VDK76799.1 - 0.047 13.3 0.0 0.18 11.4 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_19 PF13245.6 VDK76799.1 - 0.062 13.6 0.0 0.3 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Sterol_MT_C PF08498.10 VDK76799.1 - 0.074 13.4 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 Sterol methyltransferase C-terminal AAA_30 PF13604.6 VDK76799.1 - 0.2 11.4 0.0 0.97 9.1 0.1 2.0 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 VDK76799.1 - 0.34 10.4 1.9 2.5 7.5 0.0 2.6 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain zf-3CxxC PF13695.6 VDK76799.1 - 0.39 11.2 4.2 1.2 9.6 0.9 3.0 2 0 0 2 2 2 0 Zinc-binding domain AMOP PF03782.17 VDK76824.1 - 0.008 16.3 0.5 0.0097 16.0 0.5 1.1 1 0 0 1 1 1 1 AMOP domain BEN PF10523.9 VDK76824.1 - 0.03 14.5 0.1 0.99 9.7 0.0 2.8 1 1 1 2 2 2 0 BEN domain SAM_2 PF07647.17 VDK76825.1 - 9.3e-21 73.7 0.6 3.4e-11 43.1 0.1 2.8 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 VDK76825.1 - 3.8e-15 56.1 2.3 1.2e-12 48.1 0.3 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) TIR_2 PF13676.6 VDK76825.1 - 8.8e-11 42.4 0.0 2.7e-10 40.9 0.0 1.9 1 0 0 1 1 1 1 TIR domain DUF3361 PF11841.8 VDK76825.1 - 0.077 12.9 0.7 0.17 11.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) DUF3035 PF11233.8 VDK76826.1 - 0.0072 16.6 0.2 0.0084 16.4 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3035) Pkinase PF00069.25 VDK76829.1 - 3.4e-41 141.4 0.4 5e-21 75.3 0.3 2.7 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK76829.1 - 1.1e-09 38.0 0.3 1.1e-09 38.0 0.3 2.9 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK76829.1 - 0.0064 15.3 0.0 0.055 12.2 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase EMC3_TMCO1 PF01956.16 VDK76829.1 - 0.28 10.9 1.8 0.59 9.8 1.8 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like PAP2_C PF14360.6 VDK76831.1 - 9.3e-22 77.4 5.5 2.9e-21 75.8 5.5 1.9 1 0 0 1 1 1 1 PAP2 superfamily C-terminal PAP2 PF01569.21 VDK76831.1 - 1.4e-05 24.9 0.7 1.4e-05 24.9 0.7 1.7 2 0 0 2 2 2 1 PAP2 superfamily Arfaptin PF06456.13 VDK76833.1 - 4.7e-52 176.8 10.7 6.1e-52 176.5 10.7 1.1 1 0 0 1 1 1 1 Arfaptin-like domain BAR PF03114.18 VDK76833.1 - 2.1e-11 44.0 10.5 3.2e-11 43.4 10.5 1.2 1 0 0 1 1 1 1 BAR domain Fam20C PF06702.12 VDK76833.1 - 0.014 15.2 0.5 0.022 14.6 0.1 1.6 2 0 0 2 2 2 0 Golgi casein kinase, C-terminal, Fam20 E2R135 PF11570.8 VDK76833.1 - 0.13 12.6 0.7 0.69 10.2 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 Arfaptin PF06456.13 VDK76834.1 - 4.7e-52 176.8 10.7 6.1e-52 176.5 10.7 1.1 1 0 0 1 1 1 1 Arfaptin-like domain BAR PF03114.18 VDK76834.1 - 2.1e-11 44.0 10.5 3.2e-11 43.4 10.5 1.2 1 0 0 1 1 1 1 BAR domain Fam20C PF06702.12 VDK76834.1 - 0.014 15.2 0.5 0.022 14.6 0.1 1.6 2 0 0 2 2 2 0 Golgi casein kinase, C-terminal, Fam20 E2R135 PF11570.8 VDK76834.1 - 0.13 12.6 0.7 0.69 10.2 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil receptor-binding R-domain of colicin E2 Ion_trans_2 PF07885.16 VDK76846.1 - 4.4e-25 87.5 16.5 2e-17 62.9 0.1 2.6 3 0 0 3 3 3 2 Ion channel PH PF00169.29 VDK76849.1 - 1.6e-05 25.4 0.2 6e-05 23.5 0.1 2.1 2 0 0 2 2 2 1 PH domain RUN PF02759.19 VDK76849.1 - 0.00024 21.1 0.2 0.00067 19.6 0.2 1.7 1 0 0 1 1 1 1 RUN domain ENTH PF01417.20 VDK76850.1 - 4.7e-47 159.1 0.1 8.2e-47 158.3 0.1 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 VDK76850.1 - 8e-10 38.2 0.1 1.1e-09 37.7 0.1 1.3 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 VDK76850.1 - 7.3e-05 22.6 0.2 0.00013 21.8 0.2 1.3 1 0 0 1 1 1 1 VHS domain zf-C2H2_4 PF13894.6 VDK76853.1 - 0.37 11.7 33.6 0.34 11.9 0.5 6.6 6 0 0 6 6 6 0 C2H2-type zinc finger AKAP95 PF04988.12 VDK76853.1 - 4.1 7.6 11.8 1.9 8.7 0.8 3.4 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) Neur_chan_memb PF02932.16 VDK76855.1 - 2.1e-66 224.4 4.6 2.7e-66 224.0 4.6 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 VDK76855.1 - 7.3e-58 195.6 0.1 1.8e-49 168.1 0.0 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel ligand binding domain Claudin_2 PF13903.6 VDK76855.1 - 0.33 10.7 4.8 0.18 11.5 2.0 1.9 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Zona_pellucida PF00100.23 VDK76860.1 - 6.3e-14 52.4 4.3 7.7e-14 52.1 4.3 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain ANF_receptor PF01094.28 VDK76861.1 - 4e-75 253.1 0.0 5.9e-75 252.6 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 VDK76861.1 - 2.4e-53 181.3 20.7 3.4e-53 180.8 20.0 1.6 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Peripla_BP_6 PF13458.6 VDK76861.1 - 1.2e-06 28.4 0.0 2e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Periplasmic binding protein NCD3G PF07562.14 VDK76861.1 - 0.00011 22.1 18.6 0.0012 18.8 18.6 2.4 1 1 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR GST_C_3 PF14497.6 VDK76862.1 - 1.8e-14 53.7 0.0 3e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 VDK76862.1 - 0.00012 22.2 0.0 0.00019 21.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 VDK76862.1 - 0.00048 20.4 0.0 0.00094 19.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 VDK76862.1 - 0.0013 19.4 0.0 0.0024 18.6 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 VDK76862.1 - 0.0084 16.1 0.0 0.011 15.7 0.0 1.4 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 VDK76862.1 - 0.0084 16.5 0.0 0.047 14.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Phage_portal PF04860.12 VDK76862.1 - 0.037 13.2 0.1 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 Phage portal protein GST_N_2 PF13409.6 VDK76862.1 - 0.047 14.0 0.0 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Adenylsucc_synt PF00709.21 VDK76871.1 - 2.9e-165 550.3 0.0 3.3e-165 550.1 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase ARF7EP_C PF14949.6 VDK76872.1 - 4.4e-27 94.7 4.6 5.7e-27 94.4 4.6 1.1 1 0 0 1 1 1 1 ARF7 effector protein C-terminus Baculo_11_kDa PF06143.11 VDK76876.1 - 0.0087 15.6 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Baculovirus 11 kDa family Virul_fac_BrkB PF03631.15 VDK76876.1 - 0.025 14.2 0.4 0.033 13.8 0.4 1.1 1 0 0 1 1 1 0 Virulence factor BrkB ASFV_J13L PF05568.11 VDK76876.1 - 0.037 13.8 0.3 0.45 10.2 0.0 2.2 2 0 0 2 2 2 0 African swine fever virus J13L protein TMEM154 PF15102.6 VDK76876.1 - 0.038 13.9 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family DUF5385 PF17359.2 VDK76876.1 - 0.059 12.9 0.0 0.093 12.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) EphA2_TM PF14575.6 VDK76876.1 - 0.06 14.2 0.0 0.1 13.5 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF1772 PF08592.11 VDK76876.1 - 0.14 12.5 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Pellino PF04710.14 VDK76882.1 - 1.9e-173 576.9 0.1 2.7e-173 576.4 0.1 1.0 1 0 0 1 1 1 1 Pellino Prok-RING_4 PF14447.6 VDK76882.1 - 0.0018 18.1 3.3 0.89 9.5 0.1 3.4 2 1 0 2 2 2 2 Prokaryotic RING finger family 4 zf-Di19 PF05605.12 VDK76882.1 - 0.041 14.2 1.6 3.1 8.1 0.2 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING_UBOX PF13445.6 VDK76882.1 - 0.074 13.1 2.8 5 7.2 0.2 3.3 1 1 2 3 3 3 0 RING-type zinc-finger zf-RING_2 PF13639.6 VDK76882.1 - 0.26 11.7 4.2 6.2 7.3 0.1 3.2 3 0 0 3 3 3 0 Ring finger domain MAPKK1_Int PF08923.10 VDK76885.1 - 3.8e-21 75.1 0.3 4.1e-21 75.0 0.3 1.0 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting Robl_LC7 PF03259.17 VDK76885.1 - 0.048 13.4 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 Roadblock/LC7 domain DEAD PF00270.29 VDK76886.1 - 4.5e-21 75.4 0.0 3.3e-17 62.8 0.0 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK76886.1 - 1.4e-18 67.2 0.6 5e-18 65.5 0.6 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK76886.1 - 1.5e-17 64.2 0.0 4.5e-15 56.1 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit RIG-I_C-RD PF11648.8 VDK76886.1 - 1.7e-15 57.3 1.9 7.1e-15 55.3 1.1 2.3 2 0 0 2 2 2 1 C-terminal domain of RIG-I RIG-I_C PF18119.1 VDK76886.1 - 1.2e-10 41.6 0.1 1.2e-10 41.6 0.1 3.0 2 0 0 2 2 2 1 RIG-I receptor C-terminal domain AAA_22 PF13401.6 VDK76886.1 - 0.0082 16.4 0.5 0.53 10.5 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_19 PF13245.6 VDK76886.1 - 0.042 14.2 0.0 0.2 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 VDK76886.1 - 0.17 11.5 0.0 0.51 9.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain Mitofilin PF09731.9 VDK76886.1 - 1.4 7.7 8.9 2.1 7.1 8.9 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ribosomal_S6e PF01092.19 VDK76887.1 - 1.7e-62 209.0 0.1 2.9e-62 208.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Dynein_light PF01221.18 VDK76891.1 - 6.4e-33 112.9 0.1 2.5e-21 75.8 0.1 2.1 2 0 0 2 2 2 2 Dynein light chain type 1 Ground-like PF04155.18 VDK76891.1 - 0.011 16.3 0.0 0.51 11.0 0.0 2.5 2 1 0 2 2 2 0 Ground-like domain 7tm_1 PF00001.21 VDK76892.1 - 0.096 12.0 21.5 4.2 6.6 21.5 2.8 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ZZ PF00569.17 VDK76904.1 - 1.6e-10 40.6 6.8 2.6e-10 39.9 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.24 VDK76904.1 - 3.1e-07 30.2 0.0 6.3e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 PB1 domain C1_2 PF03107.16 VDK76904.1 - 0.00041 20.6 7.0 0.00099 19.4 7.0 1.6 1 0 0 1 1 1 1 C1 domain SL4P PF17618.2 VDK76904.1 - 0.0031 17.5 0.1 0.0084 16.1 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized Strongylid L4 protein PLATZ PF04640.14 VDK76904.1 - 0.028 15.1 0.8 0.097 13.3 0.8 1.9 1 0 0 1 1 1 0 PLATZ transcription factor DUF4078 PF13300.6 VDK76904.1 - 0.033 14.5 0.6 0.1 12.9 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4078) HGTP_anticodon PF03129.20 VDK76904.1 - 0.037 14.2 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Anticodon binding domain zf-UBR PF02207.20 VDK76904.1 - 0.052 13.7 2.6 0.13 12.4 2.6 1.7 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) UBA_5 PF16577.5 VDK76904.1 - 0.065 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 UBA domain UBA_6 PF18039.1 VDK76904.1 - 0.15 12.0 0.1 2 8.4 0.0 2.5 2 0 0 2 2 2 0 UBA-like domain AC_N PF16214.5 VDK76904.1 - 0.26 10.4 3.4 0.39 9.8 3.4 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region HAUS6_N PF14661.6 VDK76904.1 - 2.4 7.7 5.5 0.72 9.4 1.1 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Serinc PF03348.15 VDK76905.1 - 5.7e-155 516.5 21.5 6.4e-155 516.3 21.5 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF1358 PF07096.11 VDK76905.1 - 0.0068 16.4 0.7 0.016 15.2 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1358) DUF2231 PF09990.9 VDK76905.1 - 1.2 9.6 9.1 0.3 11.5 0.2 3.5 2 1 1 3 3 3 0 Predicted membrane protein (DUF2231) Ost5 PF05251.12 VDK76907.1 - 7.4e-29 99.8 7.4 8.2e-29 99.7 7.4 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 PRA1 PF03208.19 VDK76907.1 - 0.11 12.1 6.1 0.12 12.0 6.1 1.1 1 0 0 1 1 1 0 PRA1 family protein DUF485 PF04341.12 VDK76907.1 - 0.61 10.1 8.0 0.76 9.8 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Ribosomal_S11 PF00411.19 VDK76909.1 - 3.4e-21 75.7 1.1 4.4e-21 75.3 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Gal-bind_lectin PF00337.22 VDK76910.1 - 3.8e-60 201.3 0.5 5.7e-33 113.3 0.0 2.2 2 0 0 2 2 2 2 Galactoside-binding lectin Y2_Tnp PF04986.13 VDK76910.1 - 0.03 14.4 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative transposase FERM_M PF00373.18 VDK76911.1 - 3.3e-38 130.7 0.0 1.3e-37 128.8 0.0 2.0 2 1 0 2 2 2 1 FERM central domain Kindlin_2_N PF18124.1 VDK76911.1 - 3.6e-33 113.6 0.7 9e-33 112.3 0.7 1.7 1 0 0 1 1 1 1 Kindlin-2 N-terminal domain PH PF00169.29 VDK76911.1 - 3.9e-06 27.3 0.0 8.6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 PH domain FERM_N PF09379.10 VDK76911.1 - 0.12 12.3 0.0 13 5.8 0.0 2.6 2 0 0 2 2 2 0 FERM N-terminal domain adh_short PF00106.25 VDK76912.1 - 0.00014 21.3 0.0 0.00043 19.8 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK76912.1 - 0.0004 20.0 0.0 0.001 18.7 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF3258 PF11646.8 VDK76912.1 - 0.02 15.0 0.1 4.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function DUF3258 adh_short PF00106.25 VDK76913.1 - 4.5e-20 71.9 0.0 7.8e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK76913.1 - 2e-11 43.9 0.0 3.4e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK76913.1 - 4.9e-05 23.3 0.0 7.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 VDK76913.1 - 0.014 14.8 0.0 0.058 12.9 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF773 PF05600.12 VDK76914.1 - 2.7e-100 336.5 18.8 7.3e-72 242.7 9.6 3.0 1 1 1 2 2 2 2 CDK5 regulatory subunit-associated protein 3 60KD_IMP PF02096.20 VDK76914.1 - 0.014 15.3 1.4 0.014 15.3 1.4 2.2 2 1 0 2 2 2 0 60Kd inner membrane protein DUF29 PF01724.16 VDK76914.1 - 0.36 11.1 7.6 3.5 7.9 0.1 3.3 3 1 0 3 3 3 0 Domain of unknown function DUF29 ASL_C PF08328.11 VDK76914.1 - 0.38 10.9 8.0 1 9.4 0.8 3.4 3 0 0 3 3 3 0 Adenylosuccinate lyase C-terminal DUF3450 PF11932.8 VDK76914.1 - 1.4 8.2 12.8 4.2 6.6 2.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) GTP_EFTU PF00009.27 VDK76918.1 - 1.7e-57 194.1 0.1 2.8e-57 193.4 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 VDK76918.1 - 4.1e-22 78.1 0.0 1.1e-21 76.7 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 VDK76918.1 - 5.3e-15 55.2 0.1 1.6e-14 53.7 0.1 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus RF3_C PF16658.5 VDK76918.1 - 2.9e-09 36.8 0.0 6.5e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_IV PF03764.18 VDK76918.1 - 1.1e-08 34.9 0.0 2.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 VDK76918.1 - 3.7e-05 24.0 0.0 0.00011 22.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 VDK76918.1 - 8.4e-05 22.6 0.1 0.0003 20.8 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK76918.1 - 0.0096 15.5 0.0 0.44 10.1 0.0 3.2 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 VDK76918.1 - 0.061 12.7 0.1 0.41 10.1 0.0 2.4 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit Rhomboid PF01694.22 VDK76920.1 - 4.3e-18 65.7 9.3 8.6e-18 64.8 9.3 1.4 1 0 0 1 1 1 1 Rhomboid family TauE PF01925.19 VDK76920.1 - 0.85 9.2 10.9 1.5 8.4 10.9 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE MerC PF03203.14 VDK76920.1 - 1.2 9.6 6.6 0.53 10.8 3.3 2.0 2 0 0 2 2 2 0 MerC mercury resistance protein UPA_2 PF17809.1 VDK76932.1 - 1.1e-36 125.5 0.0 2e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 UPA domain ZU5 PF00791.20 VDK76932.1 - 3.5e-34 117.1 1.7 2.1e-28 98.5 0.0 2.7 3 0 0 3 3 3 2 ZU5 domain Ank_2 PF12796.7 VDK76933.1 - 2.2e-147 480.0 42.8 1.2e-17 64.2 0.1 12.1 1 1 10 12 12 12 12 Ankyrin repeats (3 copies) Ank PF00023.30 VDK76933.1 - 7.6e-130 418.3 66.0 1.9e-08 34.4 0.0 24.1 24 0 0 24 24 24 21 Ankyrin repeat Ank_4 PF13637.6 VDK76933.1 - 4.5e-122 397.0 56.4 6.8e-12 45.7 0.4 16.4 6 5 10 18 18 18 17 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK76933.1 - 3.1e-118 371.2 37.0 1.2e-05 25.3 0.0 24.0 24 0 0 24 24 24 20 Ankyrin repeat Ank_5 PF13857.6 VDK76933.1 - 9.3e-116 376.4 49.7 1.1e-11 44.7 0.0 17.9 3 3 16 20 20 20 19 Ankyrin repeats (many copies) PK_C PF02887.16 VDK76933.1 - 0.00075 19.7 3.1 1.1 9.5 0.0 4.2 4 1 0 4 4 4 2 Pyruvate kinase, alpha/beta domain YfmQ PF10787.9 VDK76933.1 - 0.006 16.4 0.0 20 5.0 0.0 5.7 5 2 3 8 8 8 1 Uncharacterised protein from bacillus cereus group CaKB PF03185.15 VDK76933.1 - 0.16 11.6 0.0 20 4.8 0.0 2.7 3 0 0 3 3 3 0 Calcium-activated potassium channel, beta subunit Imm_superinfect PF14373.6 VDK76933.1 - 0.22 11.5 3.5 45 4.1 0.0 6.3 8 0 0 8 8 8 0 Superinfection immunity protein Spt20 PF12090.8 VDK76934.1 - 2.2 7.8 9.8 2.7 7.6 9.8 1.1 1 0 0 1 1 1 0 Spt20 family ubiquitin PF00240.23 VDK76936.1 - 0.0001 22.0 0.1 0.00038 20.2 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin family zf-AN1 PF01428.16 VDK76936.1 - 0.00052 20.1 6.6 0.00052 20.1 6.6 2.1 2 0 0 2 2 2 1 AN1-like Zinc finger Fz PF01392.22 VDK76937.1 - 5.3e-27 94.6 4.0 5.3e-27 94.6 4.0 1.9 2 0 0 2 2 2 1 Fz domain Mid1 PF12929.7 VDK76937.1 - 0.1 11.8 3.9 0.084 12.1 2.4 1.6 2 0 0 2 2 2 0 Stretch-activated Ca2+-permeable channel component FKBP_C PF00254.28 VDK76939.1 - 5.6e-31 106.7 0.0 1.2e-30 105.6 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase HMG_box PF00505.19 VDK76939.1 - 2.8e-10 40.5 12.8 0.00013 22.3 0.1 3.3 2 1 1 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK76939.1 - 3.5e-06 27.5 13.3 0.01 16.4 2.1 3.6 2 1 1 3 3 3 2 HMG-box domain Protamine_like PF06382.11 VDK76939.1 - 0.012 15.8 10.8 0.56 10.4 1.3 3.3 1 1 1 2 2 2 0 Protamine and protamine like DUF3106 PF11304.8 VDK76939.1 - 0.2 12.1 11.8 12 6.4 10.4 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) AIRS_C PF02769.22 VDK76940.1 - 6.9e-22 78.3 0.0 1.2e-21 77.5 0.0 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain HORMA PF02301.18 VDK76940.1 - 3.9e-21 75.6 0.5 2.4e-20 73.0 0.5 2.1 1 1 0 1 1 1 1 HORMA domain AIRS PF00586.24 VDK76940.1 - 2e-09 37.9 0.0 6e-09 36.5 0.0 1.8 1 1 0 1 1 1 1 AIR synthase related protein, N-terminal domain bacHORMA_2 PF18173.1 VDK76940.1 - 0.0071 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial HORMA domain 2 UbiA PF01040.18 VDK76941.1 - 9.6e-50 169.2 15.2 1.2e-49 168.9 15.2 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Glyco_transf_54 PF04666.13 VDK76942.1 - 1.3e-95 319.6 0.0 2.1e-95 319.0 0.0 1.3 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Ly49 PF08391.10 VDK76942.1 - 0.11 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region NAD_binding_4 PF07993.12 VDK76943.1 - 1.1e-53 182.1 0.0 1.3e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 VDK76943.1 - 7.1e-30 103.1 0.8 1.5e-29 102.1 0.8 1.6 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 VDK76943.1 - 0.0011 18.0 0.0 0.0028 16.7 0.0 1.6 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Peptidase_M20 PF01546.28 VDK76946.1 - 1.1e-36 126.5 0.0 1.6e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 VDK76946.1 - 9.9e-10 38.3 0.0 1.7e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 VDK76946.1 - 0.0059 16.3 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 DEAD PF00270.29 VDK76947.1 - 3.6e-35 121.3 0.0 6.9e-35 120.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK76947.1 - 1e-24 87.0 0.0 5.4e-24 84.7 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK76947.1 - 7.4e-09 35.8 0.0 2.1e-08 34.4 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 VDK76947.1 - 0.00083 19.6 0.0 0.0032 17.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK76947.1 - 0.0016 18.2 0.0 0.0036 17.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 VDK76947.1 - 0.011 16.1 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain UTP25 PF06862.12 VDK76947.1 - 0.016 14.0 0.6 0.032 13.0 0.0 1.7 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 UvrD-helicase PF00580.21 VDK76947.1 - 0.025 14.1 0.4 0.07 12.6 0.0 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA PF00004.29 VDK76947.1 - 0.045 14.2 0.0 0.52 10.7 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Helicase_RecD PF05127.14 VDK76947.1 - 0.061 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Helicase Alpha_L_fucos PF01120.17 VDK76949.1 - 5.7e-111 371.4 12.4 7.5e-111 371.0 12.4 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase Med31 PF05669.12 VDK76949.1 - 9.3 6.3 7.8 21 5.2 5.8 2.6 2 1 0 2 2 2 0 SOH1 NUC153 PF08159.12 VDK76961.1 - 1.2e-07 31.4 11.6 4.8e-06 26.3 0.1 4.3 4 0 0 4 4 4 2 NUC153 domain Tex_YqgF PF16921.5 VDK76961.1 - 0.12 12.9 0.2 0.26 11.8 0.2 1.6 1 0 0 1 1 1 0 Tex protein YqgF-like domain GvpK PF05121.12 VDK76961.1 - 5.9 7.0 9.9 16 5.6 0.1 4.1 4 0 0 4 4 4 0 Gas vesicle protein K tRNA-synt_1g PF09334.11 VDK76962.1 - 2.9e-141 470.8 0.5 3.7e-141 470.4 0.5 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA_bind PF01588.20 VDK76962.1 - 1.5e-31 108.4 0.1 3.1e-31 107.3 0.1 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain tRNA-synt_1 PF00133.22 VDK76962.1 - 1.6e-07 30.0 0.1 0.00014 20.3 0.0 2.8 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) zinc-ribbons_6 PF07191.12 VDK76962.1 - 0.22 11.5 3.7 0.53 10.3 3.7 1.6 1 0 0 1 1 1 0 zinc-ribbons C1_1 PF00130.22 VDK76962.1 - 0.24 11.3 4.3 3.5 7.6 0.3 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 VDK76962.1 - 4.2 7.5 7.9 1.4 9.0 3.3 2.4 1 1 1 2 2 2 0 Double zinc ribbon Y_phosphatase PF00102.27 VDK76963.1 - 1.6e-71 240.6 0.3 2.2e-71 240.2 0.3 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK76963.1 - 4.3e-06 26.6 0.1 1e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK76963.1 - 0.00015 21.8 0.0 0.0022 18.0 0.0 2.4 3 0 0 3 3 3 1 Tyrosine phosphatase family GRP PF07172.11 VDK76966.1 - 0.55 10.9 7.8 0.95 10.2 7.8 1.3 1 0 0 1 1 1 0 Glycine rich protein family FoP_duplication PF13865.6 VDK76966.1 - 7.1 7.3 12.6 12 6.5 12.6 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Chromadorea_ALT PF05535.12 VDK76970.1 - 6.9e-32 109.5 10.4 8.5e-32 109.2 7.5 1.9 1 1 1 2 2 2 1 Chromadorea ALT protein COPI_C PF06957.11 VDK76971.1 - 7.2e-167 555.2 0.0 1e-166 554.7 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus Coatomer_WDAD PF04053.14 VDK76971.1 - 1.2e-132 443.1 2.4 2e-132 442.5 2.4 1.3 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 VDK76971.1 - 6.9e-40 134.3 20.7 7.3e-07 29.8 0.1 8.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK76971.1 - 2.7e-11 43.6 0.9 2e-06 28.0 0.1 5.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain NUP214 PF16755.5 VDK76971.1 - 0.0028 17.0 0.0 0.0068 15.7 0.0 1.5 1 1 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Nup160 PF11715.8 VDK76971.1 - 0.045 12.4 2.9 2.7 6.6 0.6 3.4 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DSPc PF00782.20 VDK76973.1 - 1e-25 90.1 0.0 2.1e-25 89.1 0.0 1.5 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Ribosomal_S25 PF03297.15 VDK76982.1 - 1.7e-41 140.5 2.3 1.7e-41 140.5 2.3 2.2 2 0 0 2 2 2 1 S25 ribosomal protein TrmB PF01978.19 VDK76982.1 - 0.085 12.8 0.3 0.18 11.7 0.3 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.19 VDK76982.1 - 0.094 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Sec23_trunk PF04811.15 VDK76983.1 - 8.8e-66 221.9 0.0 1.2e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 VDK76983.1 - 2.3e-30 105.2 0.1 1.2e-29 102.9 0.1 2.3 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 VDK76983.1 - 7e-24 83.6 0.1 1.5e-23 82.6 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 VDK76983.1 - 9.4e-16 57.6 6.8 1.8e-15 56.7 6.8 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 VDK76983.1 - 4e-13 49.1 0.0 8e-13 48.1 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 VDK76983.1 - 0.0067 15.8 0.4 0.016 14.6 0.4 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zinc_ribbon_10 PF10058.9 VDK76983.1 - 0.48 10.2 2.6 1 9.1 2.6 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein SNAP PF14938.6 VDK76987.1 - 1.3e-18 67.4 19.6 1.7e-18 67.0 19.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 VDK76987.1 - 1.2e-05 25.4 4.7 0.00081 19.6 0.1 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK76987.1 - 9.2e-05 22.0 1.2 0.00026 20.5 0.1 1.9 2 0 0 2 2 2 1 MalT-like TPR region DUF2989 PF11207.8 VDK76987.1 - 0.00074 19.3 0.2 0.00074 19.3 0.2 2.7 3 1 0 3 3 3 1 Protein of unknown function (DUF2989) TOM20_plant PF06552.12 VDK76987.1 - 0.0012 18.6 2.8 0.047 13.4 0.2 3.0 2 1 1 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_19 PF14559.6 VDK76987.1 - 0.0032 17.9 2.6 0.047 14.2 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.9 VDK76987.1 - 0.0071 16.1 5.2 0.028 14.1 3.8 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain TPR_7 PF13176.6 VDK76987.1 - 0.011 15.7 0.7 23 5.3 0.0 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF4810 PF16068.5 VDK76987.1 - 0.02 15.4 0.3 0.02 15.4 0.3 2.0 2 1 0 2 2 1 0 Domain of unknown function (DUF4810) TPR_6 PF13174.6 VDK76987.1 - 0.022 15.4 2.9 9.6 7.1 0.0 4.3 5 0 0 5 5 3 0 Tetratricopeptide repeat Foie-gras_1 PF11817.8 VDK76987.1 - 0.026 14.1 4.7 0.011 15.3 1.8 1.9 2 1 1 3 3 3 0 Foie gras liver health family 1 CdhD PF03599.16 VDK76987.1 - 0.057 12.1 0.4 0.18 10.5 0.0 1.8 2 0 0 2 2 2 0 CO dehydrogenase/acetyl-CoA synthase delta subunit DUF3417 PF11897.8 VDK76987.1 - 0.12 12.9 0.8 0.57 10.6 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3417) TPR_8 PF13181.6 VDK76987.1 - 0.61 10.5 9.4 26 5.4 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 VDK76987.1 - 0.62 10.3 17.2 27 5.2 0.5 6.9 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK76987.1 - 0.94 9.4 18.0 11 6.0 0.0 6.6 7 1 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK76987.1 - 5.4 7.3 11.4 0.75 10.1 0.3 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF4806 PF16064.5 VDK76989.1 - 0.014 15.7 0.1 0.051 13.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4806) Cmyb_C PF09316.10 VDK76989.1 - 0.055 13.1 0.5 0.15 11.7 0.1 1.9 2 0 0 2 2 2 0 C-myb, C-terminal GTP-bdg_M PF16360.5 VDK76989.1 - 0.086 13.4 1.5 3 8.5 0.1 2.7 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region FlaC_arch PF05377.11 VDK76989.1 - 0.95 9.9 4.1 4.4 7.8 0.3 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Xan_ur_permease PF00860.20 VDK76991.1 - 1.8e-103 346.3 28.7 2.8e-103 345.6 28.7 1.2 1 0 0 1 1 1 1 Permease family Peptidase_S8 PF00082.22 VDK76994.1 - 1.9e-41 142.3 0.8 3e-41 141.6 0.8 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 VDK76994.1 - 1.9e-23 82.3 0.1 3.6e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 VDK76994.1 - 4.5e-16 59.4 0.7 8.5e-16 58.5 0.7 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain EGF_2 PF07974.13 VDK76996.1 - 2.4e-16 59.8 124.5 0.00013 22.2 8.7 7.5 7 0 0 7 7 7 5 EGF-like domain Cadherin PF00028.17 VDK76996.1 - 6.9e-07 29.6 0.2 5.1e-06 26.8 0.0 2.5 2 0 0 2 2 2 1 Cadherin domain CARDB PF07705.11 VDK76996.1 - 0.0012 19.1 0.2 0.23 11.7 0.0 4.0 3 1 0 3 3 3 1 CARDB TIG PF01833.24 VDK76996.1 - 0.0013 18.7 0.0 0.049 13.7 0.0 3.8 3 0 0 3 3 3 1 IPT/TIG domain EGF PF00008.27 VDK76996.1 - 0.0017 18.6 7.1 0.0017 18.6 7.1 7.8 7 0 0 7 7 7 4 EGF-like domain DUF2012 PF09430.10 VDK76996.1 - 0.064 13.4 1.1 4.4 7.4 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 VDK76996.1 - 0.09 13.1 2.0 2.4 8.5 0.0 3.8 4 0 0 4 4 4 0 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 VDK76996.1 - 0.12 12.7 0.4 3.2 8.0 0.1 3.1 2 0 0 2 2 2 0 SdrD B-like domain BTB PF00651.31 VDK76997.1 - 1.2e-16 60.9 1.7 1.3e-07 31.8 0.2 3.3 2 1 0 2 2 2 2 BTB/POZ domain BACK PF07707.15 VDK76997.1 - 9.5e-07 28.9 1.2 1.9e-05 24.7 0.1 3.4 3 0 0 3 3 3 1 BTB And C-terminal Kelch Pkinase_Tyr PF07714.17 VDK77003.1 - 6.1e-29 101.1 0.7 6.1e-29 101.1 0.7 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 VDK77003.1 - 1.6e-10 40.8 0.1 1.6e-10 40.8 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77004.1 - 4.8e-41 140.8 0.1 6e-41 140.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK77004.1 - 2.3e-28 99.3 0.2 2.7e-28 99.0 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK77004.1 - 2.4e-10 40.3 0.0 4.2e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 SH2 domain CP_ATPgrasp_1 PF04174.13 VDK77004.1 - 0.0081 15.2 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 A circularly permuted ATPgrasp CP_ATPgrasp_2 PF14403.6 VDK77004.1 - 0.046 12.6 0.0 0.059 12.3 0.0 1.1 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 Kdo PF06293.14 VDK77004.1 - 0.079 12.3 0.1 0.17 11.2 0.1 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Rpr2 PF04032.16 VDK77005.1 - 4.1 7.8 7.7 9.3 6.6 4.1 2.7 2 1 1 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain RRM_1 PF00076.22 VDK77006.1 - 8e-88 288.3 5.2 4e-21 74.6 0.2 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 VDK77006.1 - 3.3e-29 100.8 3.7 3.2e-27 94.5 1.8 3.2 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 VDK77006.1 - 1.4e-10 40.8 1.8 0.054 13.1 0.0 4.7 2 1 3 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 VDK77006.1 - 3.9e-10 39.6 0.9 0.17 11.9 0.0 4.4 4 0 0 4 4 4 3 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 VDK77006.1 - 3.5e-07 30.0 0.0 0.15 11.9 0.0 3.7 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 VDK77006.1 - 4.6e-07 29.9 0.6 0.067 13.3 0.1 4.9 3 1 1 4 4 4 2 RNA recognition motif SET_assoc PF11767.8 VDK77006.1 - 6.1e-06 25.8 0.5 2.3 7.9 0.1 4.4 4 0 0 4 4 4 1 Histone lysine methyltransferase SET associated RRM_3 PF08777.11 VDK77006.1 - 3.2e-05 23.9 7.4 0.21 11.6 0.1 3.8 4 0 0 4 4 4 2 RNA binding motif Limkain-b1 PF11608.8 VDK77006.1 - 4.6e-05 23.4 0.6 1.8 8.7 0.0 4.2 4 0 0 4 4 4 1 Limkain b1 OB_RNB PF08206.11 VDK77006.1 - 0.0079 15.9 3.1 11 5.7 0.0 3.5 3 0 0 3 3 3 1 Ribonuclease B OB domain PHM7_cyt PF14703.6 VDK77006.1 - 0.0093 16.2 2.3 6 7.1 0.0 4.3 4 1 1 5 5 5 1 Cytosolic domain of 10TM putative phosphate transporter DHHA1 PF02272.19 VDK77006.1 - 0.38 11.2 2.7 24 5.3 0.2 3.1 2 1 1 3 3 3 0 DHHA1 domain Tup_N PF08581.10 VDK77007.1 - 0.0097 16.2 1.7 0.0097 16.2 1.7 3.0 2 1 0 2 2 2 1 Tup N-terminal HEPN_AbiA_CTD PF18732.1 VDK77007.1 - 0.073 13.0 1.7 0.24 11.3 0.0 2.7 3 0 0 3 3 3 0 HEPN like, Abia C-terminal domain DUF2721 PF11026.8 VDK77007.1 - 1.5 8.8 3.0 12 5.8 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF4164 PF13747.6 VDK77007.1 - 4.4 7.6 11.1 0.37 11.1 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) Guanylate_cyc PF00211.20 VDK77008.1 - 7.3e-48 162.6 0.1 1.1e-47 162.0 0.1 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 VDK77008.1 - 6.6e-30 104.2 2.9 1.4e-27 96.5 2.9 2.2 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 VDK77008.1 - 4.9e-11 42.9 0.0 2.3e-10 40.6 0.0 2.2 2 0 0 2 2 2 1 Haem-NO-binding WD40 PF00400.32 VDK77009.1 - 0.0013 19.6 23.9 3.3 8.7 0.6 8.4 10 0 0 10 10 10 4 WD domain, G-beta repeat Spc7 PF08317.11 VDK77010.1 - 0.00066 18.7 21.7 0.00066 18.7 21.7 2.1 2 0 0 2 2 2 1 Spc7 kinetochore protein IFT57 PF10498.9 VDK77010.1 - 0.0074 15.3 10.0 0.0074 15.3 10.0 2.4 1 1 0 2 2 2 1 Intra-flagellar transport protein 57 DUF465 PF04325.13 VDK77010.1 - 0.014 15.4 10.0 0.014 15.4 10.0 4.7 5 1 1 6 6 6 0 Protein of unknown function (DUF465) BLOC1_2 PF10046.9 VDK77010.1 - 0.024 14.9 5.9 0.024 14.9 5.9 3.9 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2968 PF11180.8 VDK77010.1 - 3.4 7.3 25.1 0.2 11.2 12.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2968) ADIP PF11559.8 VDK77010.1 - 4.9 7.2 40.2 0.17 12.0 22.0 2.5 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding FUSC PF04632.12 VDK77010.1 - 5.1 5.5 5.3 2.9 6.3 2.9 1.6 1 1 0 2 2 2 0 Fusaric acid resistance protein family O-FucT PF10250.9 VDK77012.1 - 9.4e-62 209.6 0.6 1.1e-61 209.4 0.6 1.0 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase SNARE PF05739.19 VDK77013.1 - 1.8e-05 24.7 2.4 2.9e-05 24.0 2.4 1.4 1 0 0 1 1 1 1 SNARE domain ThrE PF06738.12 VDK77013.1 - 0.031 13.6 0.1 0.063 12.6 0.1 1.3 1 1 0 1 1 1 0 Putative threonine/serine exporter IFT81_CH PF18383.1 VDK77014.1 - 9.7e-44 148.6 1.2 9.7e-44 148.6 1.2 4.2 4 1 0 5 5 5 1 Intraflagellar transport 81 calponin homology domain DUF1948 PF09185.10 VDK77014.1 - 0.38 10.6 0.0 0.38 10.6 0.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF1948) zf-BED PF02892.15 VDK77016.1 - 1.1e-06 28.5 13.8 0.00016 21.6 5.5 2.4 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_12 PF18658.1 VDK77016.1 - 0.013 15.1 9.0 0.098 12.2 0.5 2.7 3 0 0 3 3 3 0 Zinc-finger C2H2-type FYVE PF01363.21 VDK77016.1 - 0.025 14.7 4.3 0.025 14.7 4.3 2.3 2 0 0 2 2 2 0 FYVE zinc finger OrsD PF12013.8 VDK77016.1 - 0.032 14.7 6.4 2.2 8.7 0.3 2.3 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-UDP PF14569.6 VDK77016.1 - 0.069 13.3 0.7 4.8 7.4 0.1 2.6 2 0 0 2 2 2 0 Zinc-binding RING-finger zf-BED PF02892.15 VDK77017.1 - 1.3e-05 25.1 21.6 0.0043 17.1 7.1 2.5 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_12 PF18658.1 VDK77017.1 - 0.07 12.7 9.4 0.22 11.1 3.1 2.5 2 0 0 2 2 2 0 Zinc-finger C2H2-type DUF3222 PF11519.8 VDK77017.1 - 0.32 11.3 4.7 2.2 8.6 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3222) FYVE PF01363.21 VDK77017.1 - 0.85 9.8 10.6 0.24 11.5 1.9 2.4 2 0 0 2 2 2 0 FYVE zinc finger Spermine_synth PF01564.17 VDK77036.1 - 3.3e-06 26.7 0.3 1e-05 25.1 0.1 1.8 1 1 1 2 2 2 1 Spermine/spermidine synthase domain MTS PF05175.14 VDK77036.1 - 0.0054 16.3 0.0 0.0093 15.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 VDK77036.1 - 0.0067 17.1 0.2 0.021 15.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF3176 PF11374.8 VDK77036.1 - 0.16 12.2 0.4 8.2 6.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3176) PDZ PF00595.24 VDK77037.1 - 4.5e-18 65.4 1.0 1.1e-17 64.1 1.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK77037.1 - 1.5e-10 40.8 0.0 3.9e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 VDK77037.1 - 7.9e-10 39.2 1.0 4.8e-05 23.8 0.1 2.9 3 0 0 3 3 3 2 PH domain PH_17 PF18012.1 VDK77037.1 - 2.4e-07 30.4 0.0 4.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 PH domain PDZ_2 PF13180.6 VDK77037.1 - 1.6e-06 28.4 0.1 3.7e-06 27.2 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Motile_Sperm PF00635.26 VDK77039.1 - 2.2e-18 66.1 0.8 3.3e-18 65.5 0.8 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain BslA PF17735.1 VDK77039.1 - 0.027 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 Biofilm surface layer A DUF5374 PF17344.2 VDK77039.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5374) Roc PF08477.13 VDK77041.1 - 1.4e-10 41.4 0.0 1.9e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK77041.1 - 2.8e-06 27.0 0.0 3.3e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Arf PF00025.21 VDK77041.1 - 3.1e-05 23.5 0.0 4.9e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 VDK77041.1 - 0.0063 15.7 0.0 0.51 9.5 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit AAA_18 PF13238.6 VDK77041.1 - 0.0071 16.9 0.0 0.0094 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 VDK77041.1 - 0.065 12.6 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK77041.1 - 0.15 12.2 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ras PF00071.22 VDK77042.1 - 7.9e-47 158.9 3.2 3.5e-44 150.2 0.8 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 VDK77042.1 - 8.3e-24 84.1 1.1 3.7e-19 69.1 0.2 2.4 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK77042.1 - 6.3e-11 42.0 1.7 2.1e-10 40.3 1.0 1.8 1 1 1 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK77042.1 - 1e-05 25.2 0.1 5.6e-05 22.8 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK77042.1 - 1.2e-05 25.3 0.2 0.025 14.5 0.1 2.1 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 VDK77042.1 - 0.00014 21.4 0.2 0.17 11.4 0.1 2.3 1 1 0 2 2 2 2 Ferrous iron transport protein B Gtr1_RagA PF04670.12 VDK77042.1 - 0.00025 20.5 0.3 0.0008 18.8 0.1 1.9 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK77042.1 - 0.00042 20.4 0.2 0.18 11.9 0.0 2.7 1 1 2 3 3 3 2 50S ribosome-binding GTPase AAA_22 PF13401.6 VDK77042.1 - 0.0036 17.6 0.0 0.019 15.2 0.0 1.9 1 1 1 2 2 2 1 AAA domain ATPase_2 PF01637.18 VDK77042.1 - 0.047 13.6 0.4 0.16 11.9 0.4 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 VDK77042.1 - 0.049 13.4 0.4 0.36 10.6 0.4 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 VDK77042.1 - 0.053 13.9 0.0 0.069 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain GDP_Man_Dehyd PF16363.5 VDK77043.1 - 9.2e-69 232.4 0.0 1e-68 232.2 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 VDK77043.1 - 3.6e-52 177.2 0.0 5e-52 176.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 VDK77043.1 - 5.2e-21 75.0 0.0 6e-20 71.6 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 VDK77043.1 - 4.1e-18 65.4 0.0 5.4e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 VDK77043.1 - 1.6e-14 53.7 0.2 2.1e-13 50.1 0.2 2.1 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 VDK77043.1 - 2.8e-12 46.3 0.0 4.5e-12 45.7 0.0 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain Metallophos PF00149.28 VDK77046.1 - 4.6e-35 122.0 0.8 8.1e-35 121.2 0.8 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK77046.1 - 0.014 15.8 0.1 0.036 14.5 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 VDK77046.1 - 0.059 13.0 0.0 0.092 12.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Ras PF00071.22 VDK77048.1 - 8.8e-53 178.2 0.0 1e-52 178.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK77048.1 - 1.8e-21 76.6 0.0 2.5e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK77048.1 - 2.7e-08 33.5 0.0 3.6e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK77048.1 - 0.003 17.1 0.0 0.0066 16.0 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 VDK77048.1 - 0.16 11.4 0.0 0.33 10.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF273 PF03314.14 VDK77051.1 - 0.11 12.0 0.5 0.18 11.3 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF273 ENT PF03735.14 VDK77053.1 - 4.3e-19 68.3 0.2 8.8e-19 67.4 0.2 1.6 1 0 0 1 1 1 1 ENT domain SH3_14 PF18343.1 VDK77053.1 - 0.069 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Dda helicase SH3 domain Ribosomal_L19e PF01280.20 VDK77055.1 - 4.3e-63 211.7 11.7 4.3e-63 211.7 11.7 2.0 1 1 1 2 2 2 1 Ribosomal protein L19e B9-C2 PF07162.11 VDK77056.1 - 4.4e-37 127.9 0.0 5.9e-37 127.5 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Homeodomain PF00046.29 VDK77057.1 - 3.7e-17 61.9 7.0 6e-17 61.2 7.0 1.3 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 VDK77057.1 - 2.4e-10 40.5 3.7 2.4e-10 40.5 3.7 2.0 2 0 0 2 2 2 1 LIM domain Homeobox_KN PF05920.11 VDK77057.1 - 1.2e-05 25.1 0.4 2.2e-05 24.2 0.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain RNA_pol_L_2 PF13656.6 VDK77059.1 - 8.7e-30 102.3 0.1 1.1e-29 102.0 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 VDK77059.1 - 4.4e-12 45.2 0.0 7e-12 44.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SHNi-TPR PF10516.9 VDK77059.1 - 0.083 12.4 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 SHNi-TPR Iwr1 PF08574.10 VDK77061.1 - 2.2e-09 38.2 9.5 2.2e-09 38.2 9.5 2.5 3 0 0 3 3 3 1 Transcription factor Iwr1 GP67 PF17634.2 VDK77061.1 - 0.028 14.8 1.9 0.028 14.8 1.9 2.5 2 0 0 2 2 2 0 Gene product 67 ANAPC_CDC26 PF10471.9 VDK77062.1 - 0.0049 17.7 2.5 0.0079 17.0 2.5 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Herpes_UL25 PF01499.16 VDK77062.1 - 0.072 11.6 0.2 0.079 11.5 0.2 1.0 1 0 0 1 1 1 0 Herpesvirus UL25 family Pkinase PF00069.25 VDK77063.1 - 6.9e-36 124.0 0.0 9.2e-36 123.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77063.1 - 6.5e-16 58.4 0.0 8.6e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK77063.1 - 4.3e-05 23.0 0.0 0.0055 16.1 0.0 2.8 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 VDK77063.1 - 0.00014 20.9 0.0 0.0002 20.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 VDK77063.1 - 0.0011 18.9 0.1 0.083 12.8 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 VDK77063.1 - 0.0032 16.6 0.0 0.0056 15.8 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Hexokinase_2 PF03727.16 VDK77079.1 - 4.3e-29 101.6 0.0 5.8e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Hexokinase DUF5480 PF17576.2 VDK77080.1 - 0.049 13.6 0.1 0.06 13.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5480) LRR19-TM PF15176.6 VDK77080.1 - 0.29 11.2 1.2 0.56 10.2 1.2 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain bZIP_1 PF00170.21 VDK77082.1 - 2.1e-13 50.1 11.1 4.8e-13 49.0 11.1 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 VDK77082.1 - 1.1e-06 28.7 10.0 2.5e-06 27.4 10.0 1.6 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 VDK77082.1 - 2.1e-06 28.2 5.0 4.6e-06 27.0 5.0 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor Pkinase_Tyr PF07714.17 VDK77083.1 - 4.4e-93 311.3 0.0 7.1e-93 310.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK77083.1 - 6.3e-44 150.3 0.0 8.6e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK77083.1 - 1.5e-18 66.7 0.0 3.3e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_1 PF00018.28 VDK77083.1 - 1.3e-14 53.5 0.2 3.5e-14 52.1 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 VDK77083.1 - 2.4e-14 52.9 0.1 5.9e-14 51.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK77083.1 - 6.3e-09 35.4 0.0 1.4e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 VDK77083.1 - 0.0027 17.7 0.0 0.0068 16.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 VDK77083.1 - 0.031 14.6 0.1 0.065 13.5 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain SH3_4 PF06347.13 VDK77083.1 - 0.097 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain LysM PF01476.20 VDK77084.1 - 3.8e-06 26.8 0.0 8.1e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 LysM domain PgaD PF13994.6 VDK77084.1 - 0.15 12.1 0.1 0.4 10.7 0.1 1.7 1 0 0 1 1 1 0 PgaD-like protein Iso_dh PF00180.20 VDK77085.1 - 5.5e-103 344.8 0.0 6.7e-103 344.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Ldl_recept_b PF00058.17 VDK77085.1 - 0.085 13.3 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 Low-density lipoprotein receptor repeat class B PdxA PF04166.12 VDK77085.1 - 0.093 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA BAR PF03114.18 VDK77086.1 - 1.1e-60 205.3 9.2 1.4e-60 205.0 9.2 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 VDK77086.1 - 1.6e-12 47.2 3.8 1.8e-10 40.5 2.3 2.1 2 0 0 2 2 2 2 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3 PF16746.5 VDK77086.1 - 0.00044 20.0 4.2 0.0012 18.6 4.2 1.7 1 1 0 1 1 1 1 BAR domain of APPL family SH3_1 PF00018.28 VDK77086.1 - 0.0057 16.2 0.4 0.011 15.3 0.4 1.5 1 0 0 1 1 1 1 SH3 domain TraC_F_IV PF11130.8 VDK77086.1 - 0.012 15.2 0.6 0.017 14.7 0.6 1.2 1 0 0 1 1 1 0 F pilus assembly Type-IV secretion system for plasmid transfer DUF3461 PF11944.8 VDK77086.1 - 0.39 10.8 6.8 1.5 8.9 6.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) Vac14_Fig4_bd PF11916.8 VDK77087.1 - 1.2e-59 201.0 8.0 1.2e-59 201.0 8.0 2.2 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 VDK77087.1 - 3.8e-46 155.6 0.1 8.3e-40 135.3 0.0 4.7 3 1 1 4 4 4 3 Vacuolar 14 Fab1-binding region HEAT PF02985.22 VDK77087.1 - 1.3e-10 40.6 9.3 4.6e-05 23.3 0.0 7.2 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 VDK77087.1 - 8e-10 39.0 0.4 0.028 14.8 0.0 5.2 4 2 2 6 6 6 3 HEAT repeats HEAT_EZ PF13513.6 VDK77087.1 - 4.8e-09 36.5 5.2 0.0039 17.6 0.0 5.6 6 0 0 6 6 6 2 HEAT-like repeat CLASP_N PF12348.8 VDK77087.1 - 1e-08 35.1 0.1 0.052 13.1 0.0 4.4 1 1 2 4 4 4 2 CLASP N terminal Tti2 PF10521.9 VDK77087.1 - 0.00016 21.4 2.5 1 8.8 0.0 3.9 3 1 0 3 3 3 2 Tti2 family Cnd1 PF12717.7 VDK77087.1 - 0.00057 20.0 5.7 2.3 8.2 0.0 5.0 3 1 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 DUF3437 PF11919.8 VDK77087.1 - 0.00098 19.0 0.0 0.0093 15.9 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) Arm PF00514.23 VDK77087.1 - 0.62 10.2 3.2 16 5.7 0.0 4.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat LRR_4 PF12799.7 VDK77088.1 - 9.5e-14 51.3 30.9 2e-06 28.0 9.0 5.1 1 1 6 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 VDK77088.1 - 1.6e-08 34.2 26.2 0.0031 17.3 6.4 4.9 1 1 5 6 6 6 6 Leucine rich repeat LRR_9 PF14580.6 VDK77088.1 - 1e-06 28.4 0.8 1e-06 28.4 0.8 3.4 3 1 0 4 4 4 1 Leucine-rich repeat LRR_6 PF13516.6 VDK77088.1 - 1.2e-05 24.9 11.5 1.4 9.2 0.5 6.0 6 0 0 6 6 6 3 Leucine Rich repeat IQ PF00612.27 VDK77088.1 - 5.9e-05 22.5 3.6 5.9e-05 22.5 3.6 2.7 3 0 0 3 3 3 1 IQ calmodulin-binding motif TolA_bind_tri PF16331.5 VDK77088.1 - 0.2 11.8 4.4 0.56 10.3 4.4 1.7 1 0 0 1 1 1 0 TolA binding protein trimerisation zf-C3HC PF07967.13 VDK77088.1 - 0.36 10.9 4.3 0.64 10.1 2.9 2.2 2 0 0 2 2 2 0 C3HC zinc finger-like Defensin_int PF17858.1 VDK77088.1 - 0.44 10.6 1.9 13 5.9 0.5 2.7 2 0 0 2 2 2 0 Platypus intermediate defensin-like peptide LRR_1 PF00560.33 VDK77088.1 - 0.73 10.6 24.4 3.9 8.4 0.2 6.5 6 2 0 6 6 6 0 Leucine Rich Repeat RAI1 PF08652.11 VDK77090.1 - 1.2e-18 67.0 0.2 1.6e-17 63.4 0.0 2.2 2 0 0 2 2 2 1 RAI1 like PD-(D/E)XK nuclease Vps5 PF09325.10 VDK77091.1 - 1.6e-55 188.2 7.3 2.3e-55 187.7 7.3 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 VDK77091.1 - 3.6e-23 81.7 0.9 2.7e-22 78.9 0.1 2.2 2 0 0 2 2 2 1 PX domain BAR_3_WASP_bdg PF10456.9 VDK77091.1 - 4.7e-05 23.0 0.7 0.18 11.2 0.0 2.4 2 0 0 2 2 2 2 WASP-binding domain of Sorting nexin protein BAR_3 PF16746.5 VDK77091.1 - 0.0041 16.9 6.0 0.0056 16.4 0.5 2.2 1 1 1 2 2 2 1 BAR domain of APPL family pP_pnuc_1 PF18165.1 VDK77091.1 - 0.012 15.5 0.4 0.047 13.6 0.4 1.9 2 0 0 2 2 2 0 Predicted pPIWI-associating nuclease V-SNARE PF05008.15 VDK77091.1 - 0.098 13.1 4.9 2.4 8.6 4.4 2.7 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus PriC PF07445.12 VDK77091.1 - 0.28 11.1 5.7 1.2 9.1 5.7 2.0 1 1 0 1 1 1 0 Primosomal replication protein priC Mod_r PF07200.13 VDK77091.1 - 0.61 10.2 8.5 2.8 8.0 4.0 3.1 1 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein NIF PF03031.18 VDK77094.1 - 2.5e-53 180.0 0.6 3.4e-53 179.6 0.6 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase K_channel_TID PF07941.11 VDK77094.1 - 0.017 15.6 9.3 0.039 14.4 9.3 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Cut8 PF08559.10 VDK77094.1 - 0.055 13.1 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Cut8, nuclear proteasome tether protein ERCC4 PF02732.15 VDK77096.1 - 5.9e-17 62.3 0.2 1.4e-16 61.1 0.2 1.7 1 0 0 1 1 1 1 ERCC4 domain SRI PF08236.11 VDK77096.1 - 8.1e-11 41.9 0.2 2.3e-10 40.5 0.2 1.7 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain WW PF00397.26 VDK77096.1 - 2.1e-08 34.1 0.4 4.6e-08 33.0 0.4 1.6 1 0 0 1 1 1 1 WW domain HHH_8 PF14716.6 VDK77096.1 - 0.0028 18.0 0.0 0.0073 16.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain GreA_GreB_N PF03449.15 VDK77096.1 - 0.08 13.1 1.2 0.26 11.5 1.2 1.8 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal HHH_2 PF12826.7 VDK77096.1 - 0.11 12.6 0.0 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif Peptidase_S66C PF17676.1 VDK77096.1 - 0.17 12.4 0.0 0.46 11.0 0.0 1.7 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain Collagen PF01391.18 VDK77102.1 - 4.8e-25 87.1 87.9 1.2e-10 41.0 34.0 3.8 2 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK77102.1 - 4.3e-09 36.3 0.0 6e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Clathrin PF00637.20 VDK77105.1 - 7.6e-203 664.6 49.0 3.9e-33 114.3 2.5 7.6 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 VDK77105.1 - 2.8e-40 134.7 1.9 2.6e-06 27.5 0.0 6.6 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 VDK77105.1 - 7e-31 105.9 2.0 4.4e-30 103.4 0.0 3.5 4 0 0 4 4 4 1 Clathrin-H-link Clathrin-link PF09268.10 VDK77105.1 - 1.9e-12 46.3 0.1 4.4e-12 45.1 0.1 1.7 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 VDK77105.1 - 1.5e-05 24.2 6.1 0.035 13.1 0.1 4.4 4 0 0 4 4 4 2 Coatomer WD associated region TPR_7 PF13176.6 VDK77105.1 - 0.15 12.1 13.8 1.1 9.4 0.1 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK77105.1 - 0.18 12.7 11.8 66 4.7 0.3 8.8 9 1 1 10 10 10 0 Tetratricopeptide repeat Flavodoxin_1 PF00258.25 VDK77107.1 - 1.4e-08 35.0 0.0 2.7e-08 34.1 0.0 1.5 2 0 0 2 2 2 1 Flavodoxin ABC1 PF03109.16 VDK77108.1 - 1.8e-15 57.2 0.0 4.5e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 VDK77108.1 - 0.007 16.0 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 VDK77108.1 - 0.038 13.9 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 VDK77108.1 - 0.051 12.9 0.4 0.13 11.6 0.0 1.8 3 0 0 3 3 3 0 Protein kinase domain Zn_ribbon_17 PF17120.5 VDK77109.1 - 8.8e-07 28.5 11.9 8.8e-07 28.5 11.9 2.6 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 VDK77109.1 - 4.2e-06 27.4 18.2 0.12 13.3 0.0 7.8 7 1 1 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK77109.1 - 0.015 15.6 1.1 2.4 8.5 0.4 3.7 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Mre11_DNA_bind PF04152.14 VDK77110.1 - 3.9e-17 63.1 0.2 8e-17 62.1 0.2 1.6 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 VDK77110.1 - 1.8e-15 58.0 0.2 3.7e-15 57.0 0.2 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 VDK77110.1 - 1.3e-05 25.5 0.0 0.00012 22.3 0.0 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Paf67 PF10255.9 VDK77110.1 - 0.1 11.5 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase I-associated factor PAF67 LUC7 PF03194.15 VDK77111.1 - 5e-65 219.7 30.5 4.2e-39 134.7 4.6 2.9 2 1 1 3 3 3 2 LUC7 N_terminus FAM91_C PF14648.6 VDK77111.1 - 0.19 10.6 0.8 0.34 9.7 0.8 1.5 1 0 0 1 1 1 0 FAM91 C-terminus FAM60A PF15396.6 VDK77111.1 - 4.5 7.2 21.0 6.9 6.6 1.1 2.3 2 0 0 2 2 2 0 Protein Family FAM60A Pkinase PF00069.25 VDK77112.1 - 1.7e-33 116.1 0.0 2.2e-33 115.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77112.1 - 1.6e-29 103.0 0.0 2.5e-29 102.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Activin_recp PF01064.23 VDK77112.1 - 0.0002 22.4 13.9 0.00044 21.3 13.9 1.6 1 0 0 1 1 1 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 VDK77112.1 - 0.00093 18.1 0.0 0.0013 17.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK77112.1 - 0.014 15.3 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family cNMP_binding PF00027.29 VDK77114.1 - 2e-34 117.5 0.1 8.2e-11 41.8 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Patatin PF01734.22 VDK77114.1 - 6.7e-22 78.7 0.1 1.7e-21 77.4 0.1 1.7 1 0 0 1 1 1 1 Patatin-like phospholipase zf-MYND PF01753.18 VDK77137.1 - 1.2e-08 34.8 12.3 1.2e-08 34.8 12.3 3.8 2 2 0 2 2 2 1 MYND finger TPR_12 PF13424.6 VDK77137.1 - 9.1e-05 22.7 0.0 0.00018 21.7 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 VDK77137.1 - 0.028 14.3 0.0 0.081 12.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 VDK77140.1 - 4.3e-51 173.8 0.0 6e-51 173.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77140.1 - 8.1e-31 107.2 0.0 9.9e-31 106.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK77140.1 - 3.4e-06 26.6 0.0 6.6e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK77140.1 - 0.00068 19.0 0.1 0.001 18.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 VDK77140.1 - 0.00082 18.3 0.0 0.0012 17.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 VDK77140.1 - 0.0009 18.3 0.0 0.0013 17.8 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 VDK77140.1 - 0.0013 18.8 0.1 0.0022 18.0 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 VDK77140.1 - 0.095 12.3 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ATP_synt_H PF05493.13 VDK77141.1 - 0.075 13.5 1.7 0.12 12.8 1.7 1.3 1 0 0 1 1 1 0 ATP synthase subunit H Ubiq_cyt_C_chap PF03981.12 VDK77143.1 - 3.7e-25 88.7 1.9 3.8e-25 88.6 0.8 1.6 2 0 0 2 2 2 1 Ubiquinol-cytochrome C chaperone DUF2815 PF10991.8 VDK77143.1 - 0.13 12.2 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2815) Asp_Arg_Hydrox PF05118.15 VDK77144.1 - 5.1e-32 110.9 0.0 1.2e-31 109.6 0.0 1.7 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase TPR_16 PF13432.6 VDK77144.1 - 5.8e-11 42.9 0.6 4.9e-05 23.9 0.0 4.3 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK77144.1 - 0.00034 20.6 0.3 12 6.4 0.1 4.3 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK77144.1 - 0.0004 20.6 0.7 1.5 9.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK77144.1 - 0.00044 20.2 0.7 29 5.1 0.4 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 VDK77144.1 - 0.00047 19.8 6.1 0.68 9.7 0.0 4.4 4 0 0 4 4 4 2 TPR repeat ANAPC3 PF12895.7 VDK77144.1 - 0.0039 17.4 0.2 0.38 11.0 0.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 VDK77144.1 - 0.0053 17.2 0.0 0.15 12.6 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 VDK77144.1 - 0.011 16.1 0.0 4.5 7.9 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK77144.1 - 0.017 15.9 1.8 0.36 11.8 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK77144.1 - 0.028 14.3 0.8 34 4.5 0.3 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK77144.1 - 0.069 13.8 2.5 5.5 7.8 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Connexin PF00029.19 VDK77144.1 - 0.68 9.7 0.0 0.68 9.7 0.0 3.2 2 1 0 3 3 2 0 Connexin ABC_membrane PF00664.23 VDK77147.1 - 6.8e-55 186.6 41.4 6.2e-36 124.5 18.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 VDK77147.1 - 2.8e-47 160.7 0.0 1.8e-27 96.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 VDK77147.1 - 1.1e-10 41.4 3.3 0.13 11.7 0.0 4.5 3 1 0 4 4 4 4 RecF/RecN/SMC N terminal domain DEAD PF00270.29 VDK77147.1 - 1.6e-06 28.0 1.8 0.0015 18.3 0.4 3.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_29 PF13555.6 VDK77147.1 - 5.4e-06 26.1 0.1 0.19 11.5 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 VDK77147.1 - 1.5e-05 25.3 0.4 0.73 10.1 0.1 4.0 3 1 0 3 3 3 2 AAA domain AAA_23 PF13476.6 VDK77147.1 - 2.3e-05 25.0 5.0 0.026 15.0 0.1 3.2 3 0 0 3 3 3 2 AAA domain AAA_21 PF13304.6 VDK77147.1 - 2.7e-05 24.1 3.1 0.15 11.8 0.1 3.8 3 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system ResIII PF04851.15 VDK77147.1 - 0.00011 22.2 0.0 0.039 14.0 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 VDK77147.1 - 0.00013 21.1 0.0 0.017 14.2 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 VDK77147.1 - 0.0002 21.4 1.7 0.14 12.3 0.2 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDK77147.1 - 0.00042 20.2 0.2 0.22 11.4 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 VDK77147.1 - 0.00084 19.0 0.6 0.04 13.5 0.1 2.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 VDK77147.1 - 0.0016 18.9 0.2 0.21 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 VDK77147.1 - 0.0017 17.6 0.6 0.25 10.5 0.0 2.7 2 1 0 2 2 2 1 NB-ARC domain AAA_19 PF13245.6 VDK77147.1 - 0.0079 16.5 0.1 0.92 9.8 0.0 3.3 3 0 0 3 3 3 1 AAA domain MobB PF03205.14 VDK77147.1 - 0.0095 15.8 0.4 0.68 9.8 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 VDK77147.1 - 0.012 15.6 0.1 0.26 11.2 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 VDK77147.1 - 0.014 15.1 0.1 4.8 6.9 0.0 2.8 3 0 0 3 3 2 0 IstB-like ATP binding protein ATP_bind_1 PF03029.17 VDK77147.1 - 0.026 14.3 1.7 4.4 7.0 0.0 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA PF00004.29 VDK77147.1 - 0.03 14.8 0.2 1.2 9.6 0.0 2.9 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 VDK77147.1 - 0.031 14.2 0.2 0.38 10.6 0.1 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_18 PF13238.6 VDK77147.1 - 0.052 14.1 0.1 14 6.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 VDK77147.1 - 0.064 12.8 0.1 3.8 7.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 VDK77147.1 - 0.08 13.0 6.8 2 8.5 0.2 3.4 3 1 0 3 3 3 0 Dynamin family NACHT PF05729.12 VDK77147.1 - 0.086 12.8 0.3 5.2 7.0 0.1 2.6 2 0 0 2 2 2 0 NACHT domain SbcCD_C PF13558.6 VDK77147.1 - 0.091 13.0 3.2 2.6 8.3 0.0 3.2 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit PduV-EutP PF10662.9 VDK77147.1 - 0.1 12.3 0.3 2.7 7.7 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 VDK77147.1 - 0.13 12.0 0.0 3.3 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 VDK77147.1 - 0.13 12.3 0.0 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FtsK_SpoIIIE PF01580.18 VDK77147.1 - 0.15 11.4 0.0 19 4.5 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.13 VDK77147.1 - 0.16 12.2 0.1 9.7 6.4 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 VDK77147.1 - 0.39 10.6 4.3 11 5.9 0.0 3.8 4 0 0 4 4 4 0 NTPase AAA_15 PF13175.6 VDK77147.1 - 0.41 10.3 6.5 10 5.7 0.0 3.0 2 1 0 3 3 3 0 AAA ATPase domain Efg1 PF10153.9 VDK77147.1 - 0.5 10.7 3.6 6.3 7.2 3.5 2.5 2 0 0 2 2 2 0 rRNA-processing protein Efg1 DUF87 PF01935.17 VDK77147.1 - 5.8 6.9 6.2 4.4 7.3 0.0 3.1 3 0 0 3 3 3 0 Helicase HerA, central domain F-box-like PF12937.7 VDK77148.1 - 0.00047 20.0 0.6 0.0011 18.8 0.6 1.7 1 0 0 1 1 1 1 F-box-like Ig_2 PF13895.6 VDK77157.1 - 0.008 16.5 0.0 0.01 16.2 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 VDK77157.1 - 0.011 16.3 0.0 0.013 16.1 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 VDK77157.1 - 0.12 12.6 0.0 0.13 12.5 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin V-set domain fn3 PF00041.21 VDK77158.1 - 3.9e-88 289.9 13.3 4.6e-21 74.9 0.1 6.5 6 0 0 6 6 6 6 Fibronectin type III domain I-set PF07679.16 VDK77158.1 - 5e-58 193.2 0.2 6.2e-17 61.5 0.0 6.0 6 0 0 6 6 6 4 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK77158.1 - 4e-51 171.5 5.6 2.3e-15 56.9 0.0 7.3 9 0 0 9 9 6 4 Immunoglobulin domain Ig_2 PF13895.6 VDK77158.1 - 6.3e-38 129.0 0.0 1.9e-12 47.3 0.0 4.8 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 VDK77158.1 - 2.7e-29 101.2 0.1 3.5e-10 39.9 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 VDK77158.1 - 3.6e-22 78.7 6.1 6.6e-05 23.4 0.0 6.8 6 0 0 6 6 6 4 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 VDK77158.1 - 1.2e-19 70.4 1.2 0.029 14.5 0.0 8.0 4 3 2 6 6 6 4 Immunoglobulin V-set domain Interfer-bind PF09294.10 VDK77158.1 - 4.1e-16 59.2 0.1 0.025 14.9 0.0 5.9 6 0 0 6 6 5 4 Interferon-alpha/beta receptor, fibronectin type III C2-set_2 PF08205.12 VDK77158.1 - 2.3e-10 40.4 0.1 0.018 15.1 0.0 4.1 3 0 0 3 3 3 3 CD80-like C2-set immunoglobulin domain DUF2369 PF10179.9 VDK77158.1 - 7.5e-10 39.1 0.3 0.29 11.5 0.0 5.5 5 0 0 5 5 5 2 Uncharacterised conserved protein (DUF2369) Ig_4 PF16680.5 VDK77158.1 - 1.8e-07 31.3 0.0 0.34 11.2 0.0 4.6 4 0 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 VDK77158.1 - 9.1e-06 25.2 0.0 0.32 10.6 0.0 4.4 4 0 0 4 4 4 1 Immunoglobulin domain fn3_2 PF16893.5 VDK77158.1 - 0.00071 19.7 0.0 1.1 9.5 0.0 4.4 5 0 0 5 5 4 1 Fibronectin type III domain C1-set PF07654.15 VDK77158.1 - 0.00099 19.4 0.1 5.5 7.4 0.0 4.3 5 0 0 5 5 4 1 Immunoglobulin C1-set domain C2-set PF05790.15 VDK77158.1 - 0.0012 19.0 0.0 0.86 9.8 0.0 3.5 3 0 0 3 3 3 1 Immunoglobulin C2-set domain Arylsulfotran_N PF17425.2 VDK77158.1 - 0.0025 17.8 0.6 0.13 12.3 0.0 3.5 4 0 0 4 4 2 1 Arylsulfotransferase Ig-like domain REJ PF02010.15 VDK77158.1 - 0.013 14.4 0.3 0.96 8.2 0.1 2.4 2 0 0 2 2 2 0 REJ domain Ig_C17orf99 PF17736.1 VDK77158.1 - 0.024 14.6 0.0 0.57 10.3 0.0 3.1 2 0 0 2 2 2 0 C17orf99 Ig domain TM140 PF14985.6 VDK77158.1 - 0.048 13.2 0.1 0.078 12.5 0.1 1.2 1 0 0 1 1 1 0 TM140 protein family Herpes_gE PF02480.16 VDK77158.1 - 0.063 12.0 0.1 1.2 7.8 0.0 2.9 4 0 0 4 4 4 0 Alphaherpesvirus glycoprotein E EphA2_TM PF14575.6 VDK77158.1 - 0.089 13.7 0.0 0.23 12.4 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Neogenin_C PF06583.12 VDK77158.1 - 4 7.2 13.8 1.5 8.6 5.4 3.0 2 1 1 3 3 3 0 Neogenin C-terminus BaffR-Tall_bind PF09256.10 VDK77160.1 - 0.0097 15.7 2.0 0.012 15.3 0.3 2.1 2 1 0 2 2 2 1 BAFF-R, TALL-1 binding Topoisom_I PF01028.20 VDK77162.1 - 1.7e-101 338.4 6.0 4.6e-101 336.9 6.0 1.8 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 VDK77162.1 - 1.3e-93 312.4 1.2 1.3e-93 312.4 1.2 3.2 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 VDK77162.1 - 1.9e-32 111.0 0.9 1.9e-32 111.0 0.9 2.5 2 0 0 2 2 2 1 C-terminal topoisomerase domain DUF3881 PF12997.7 VDK77165.1 - 0.049 12.9 0.2 0.093 12.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3881) HlyIII PF03006.20 VDK77167.1 - 3.2e-14 53.2 19.7 7.4e-14 52.0 19.7 1.6 1 1 0 1 1 1 1 Haemolysin-III related DUF758 PF05527.11 VDK77168.1 - 6e-56 189.3 9.6 6.9e-56 189.1 9.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF758) Pico_P2B PF01552.17 VDK77168.1 - 0.05 13.8 1.8 0.05 13.8 1.8 2.4 2 1 1 3 3 3 0 Picornavirus 2B protein Exo70 PF03081.15 VDK77169.1 - 3.2e-50 171.2 4.1 7e-50 170.1 0.3 2.3 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Sec34 PF04136.15 VDK77169.1 - 1.8e-06 27.9 5.4 2.7e-06 27.3 3.0 2.5 2 0 0 2 2 2 1 Sec34-like family HMW1C_N PF18071.1 VDK77169.1 - 0.0026 17.6 0.4 0.01 15.6 0.2 2.2 1 1 0 1 1 1 1 HMW1C N-terminal Nup54 PF13874.6 VDK77169.1 - 0.32 11.1 4.3 0.78 9.8 4.3 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 RINGv PF12906.7 VDK77170.1 - 5.5e-13 48.8 5.4 1.1e-12 47.8 5.4 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 VDK77170.1 - 0.036 14.4 5.2 0.11 12.8 5.2 1.9 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 VDK77170.1 - 0.44 10.9 2.3 1.1 9.6 2.3 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 VDK77170.1 - 1.6 8.7 4.6 4.9 7.1 4.6 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Asp2 PF16929.5 VDK77185.1 - 0.044 12.7 4.0 0.06 12.3 4.0 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Glycohydro_20b2 PF14845.6 VDK77185.1 - 1.5 9.4 7.0 2 9.1 6.2 1.5 1 1 0 1 1 1 0 beta-acetyl hexosaminidase like RNA_pol_Rpc4 PF05132.14 VDK77187.1 - 2.7e-09 37.6 2.1 2.7e-09 37.6 2.1 3.7 2 1 1 3 3 3 1 RNA polymerase III RPC4 DNA_PPF PF02916.15 VDK77187.1 - 0.025 15.0 0.1 0.06 13.8 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase processivity factor DUF5383 PF17355.2 VDK77188.1 - 0.066 13.6 0.1 0.25 11.7 0.1 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5383) Peptidase_M18 PF02127.15 VDK77189.1 - 2.2e-170 567.2 0.0 2.5e-170 567.0 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 VDK77189.1 - 7.5e-07 28.5 0.1 0.00046 19.3 0.1 2.7 2 1 1 3 3 3 2 M42 glutamyl aminopeptidase PP-binding PF00550.25 VDK77190.1 - 3.5e-09 36.9 0.0 4.9e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site DUF1493 PF07377.12 VDK77190.1 - 0.12 12.8 1.0 0.19 12.2 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Ribosomal_L36e PF01158.18 VDK77191.1 - 7.9e-42 141.4 9.2 8.7e-42 141.3 9.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e EI24 PF07264.11 VDK77192.1 - 7.5e-13 49.1 13.9 9.5e-13 48.8 13.2 1.5 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Ribosomal_S11 PF00411.19 VDK77193.1 - 2.1e-45 153.6 1.5 2.6e-45 153.3 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 DUF2252 PF10009.9 VDK77193.1 - 0.14 11.2 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) EB PF01683.18 VDK77194.1 - 1.7e-120 393.2 212.7 4.1e-13 49.4 10.7 12.5 12 1 0 12 12 12 12 EB module Dickkopf_N PF04706.12 VDK77194.1 - 0.00071 20.0 159.7 0.0035 17.8 5.3 14.7 11 3 1 12 12 12 7 Dickkopf N-terminal cysteine-rich region DUF5356 PF17309.2 VDK77196.1 - 1.7e-39 134.9 1.9 2e-39 134.7 1.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5356) DNA_pol_E_B PF04042.16 VDK77197.1 - 2.9e-36 124.8 0.0 4.3e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 VDK77197.1 - 3.1e-28 98.5 0.0 4.9e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain MerR_2 PF13591.6 VDK77197.1 - 0.046 13.6 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 MerR HTH family regulatory protein AMP-binding PF00501.28 VDK77198.1 - 1.4e-94 317.1 0.0 1.9e-94 316.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 VDK77198.1 - 1.4e-05 26.0 0.0 7.4e-05 23.6 0.0 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Med7 PF05983.11 VDK77200.1 - 2e-39 135.7 8.5 1.6e-38 132.7 8.5 2.0 1 1 0 1 1 1 1 MED7 protein zf-H2C2_2 PF13465.6 VDK77201.1 - 1.1e-08 35.1 27.0 3.1e-05 24.2 3.4 5.0 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 VDK77201.1 - 6.6e-06 26.3 33.8 3.6e-05 24.0 1.3 4.8 5 0 0 5 5 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK77201.1 - 5.4e-05 23.7 27.9 0.00014 22.4 1.2 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 VDK77201.1 - 0.0041 17.1 5.6 0.046 13.7 0.5 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK77201.1 - 0.013 15.3 4.0 0.013 15.3 4.0 3.4 3 1 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 VDK77201.1 - 0.022 15.2 13.9 0.031 14.7 0.6 3.2 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 VDK77201.1 - 0.023 15.0 9.3 0.023 15.0 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF3268 PF11672.8 VDK77201.1 - 0.22 11.9 6.0 0.056 13.8 1.9 2.1 2 1 1 3 3 3 0 zinc-finger-containing domain BRD4_CDT PF17105.5 VDK77201.1 - 0.43 10.2 1.7 0.92 9.2 1.7 1.4 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 GAGA PF09237.11 VDK77201.1 - 2.1 8.2 7.4 0.75 9.6 2.8 2.7 2 1 1 3 3 3 0 GAGA factor Zn-ribbon_8 PF09723.10 VDK77201.1 - 3.4 7.9 18.0 11 6.2 5.6 3.6 3 0 0 3 3 3 0 Zinc ribbon domain DZR PF12773.7 VDK77201.1 - 7.8 6.6 18.2 19 5.4 0.6 3.2 2 1 0 2 2 2 0 Double zinc ribbon Topoisom_bac PF01131.20 VDK77202.1 - 5.8e-110 368.1 0.0 7.3e-110 367.8 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 VDK77202.1 - 1.2e-18 67.2 0.1 4.1e-18 65.5 0.0 2.0 2 0 0 2 2 2 1 Toprim domain zf-GRF PF06839.12 VDK77202.1 - 2.1e-14 53.3 4.2 2.1e-14 53.3 4.2 3.0 2 1 0 2 2 2 1 GRF zinc finger Mito_carr PF00153.27 VDK77203.1 - 1.3e-61 204.5 2.7 4.6e-20 71.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Amastin PF07344.11 VDK77216.1 - 0.21 11.4 14.4 0.25 11.2 14.4 1.1 1 0 0 1 1 1 0 Amastin surface glycoprotein DUF2207 PF09972.9 VDK77216.1 - 2.6 6.7 8.9 2.8 6.6 8.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PRA1 PF03208.19 VDK77216.1 - 4.5 6.9 14.0 5.8 6.5 14.0 1.2 1 0 0 1 1 1 0 PRA1 family protein DUF3043 PF11241.8 VDK77216.1 - 5.4 7.0 9.1 5.9 6.9 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Promethin PF16015.5 VDK77216.1 - 8.2 6.4 21.9 11 6.0 21.9 1.2 1 0 0 1 1 1 0 Promethin Hormone_recep PF00104.30 VDK77220.1 - 3.6e-37 127.9 2.0 4.9e-37 127.5 2.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 VDK77220.1 - 1.6e-30 105.4 14.7 2.9e-30 104.5 14.7 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) THDPS_N PF14790.6 VDK77220.1 - 0.14 12.0 0.1 0.25 11.2 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal IATP PF04568.12 VDK77220.1 - 1.7 9.1 5.6 6.4 7.3 5.6 2.0 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Patched PF02460.18 VDK77221.1 - 3e-38 131.5 25.1 5.6e-36 124.0 5.4 3.2 2 1 1 3 3 3 3 Patched family ABC2_membrane_4 PF12730.7 VDK77221.1 - 0.038 14.0 0.1 0.038 14.0 0.1 3.8 4 0 0 4 4 4 0 ABC-2 family transporter protein ACR_tran PF00873.19 VDK77221.1 - 1.1 6.8 11.9 0.6 7.7 9.1 1.7 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Patched PF02460.18 VDK77222.1 - 1.4e-95 321.1 26.7 6.7e-93 312.3 26.7 2.1 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK77222.1 - 1.2e-23 83.6 7.5 1.2e-23 83.6 7.5 3.9 2 2 2 4 4 4 1 Sterol-sensing domain of SREBP cleavage-activation ATPgrasp_ST PF14397.6 VDK77222.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp ACR_tran PF00873.19 VDK77222.1 - 0.38 8.3 30.5 0.45 8.1 14.6 2.0 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family G-7-MTase PF12803.7 VDK77235.1 - 0.015 14.5 0.9 0.032 13.4 0.9 1.4 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) Csm1 PF12539.8 VDK77235.1 - 0.085 13.5 0.2 0.39 11.4 0.2 2.2 1 0 0 1 1 1 0 Chromosome segregation protein Csm1/Pcs1 DUF2371 PF10177.9 VDK77239.1 - 0.079 13.1 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) Kringle PF00051.18 VDK77240.1 - 1.2e-07 31.9 2.5 1.2e-07 31.9 2.5 2.7 2 1 0 2 2 2 1 Kringle domain Glyco_hydro_16 PF00722.21 VDK77240.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 16 LMBR1 PF04791.16 VDK77242.1 - 5.2e-81 273.1 46.8 4.4e-48 164.5 20.6 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein RCC1 PF00415.18 VDK77243.1 - 5e-35 119.9 1.6 7.7e-06 26.4 0.0 7.3 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 VDK77243.1 - 6.7e-23 79.9 4.6 0.00045 19.9 0.0 6.6 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat DNA_ligase_A_M PF01068.21 VDK77244.1 - 3.1e-36 124.9 0.0 5.5e-36 124.1 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain BRCT PF00533.26 VDK77244.1 - 3e-13 49.9 0.7 2.2e-05 24.7 0.1 2.9 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_A_N PF04675.14 VDK77244.1 - 4.3e-12 46.7 4.2 2.9e-11 44.0 2.1 2.5 2 0 0 2 2 2 1 DNA ligase N terminus BRCT_2 PF16589.5 VDK77244.1 - 1.1e-10 41.8 0.2 0.00011 22.6 0.1 2.8 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 VDK77244.1 - 1.2e-07 32.2 0.0 6e-07 30.0 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region LIG3_BRCT PF16759.5 VDK77244.1 - 5.4e-05 23.4 0.2 0.021 15.1 0.0 2.7 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain RNA_ligase PF09414.10 VDK77244.1 - 0.00084 19.7 0.0 0.0027 18.0 0.0 1.9 1 0 0 1 1 1 1 RNA ligase DUF4868 PF16162.5 VDK77244.1 - 0.069 13.1 3.1 0.1 12.5 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4868) PNKP_ligase PF16542.5 VDK77244.1 - 0.083 12.4 0.0 0.38 10.2 0.0 2.0 1 1 1 2 2 2 0 PNKP adenylyltransferase domain, ligase domain PTCB-BRCT PF12738.7 VDK77244.1 - 0.18 11.8 0.4 9.8 6.2 0.1 2.5 2 0 0 2 2 2 0 twin BRCT domain SUIM_assoc PF16619.5 VDK77245.1 - 0.07 13.2 6.7 0.1 12.7 6.7 1.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 CYSTM PF12734.7 VDK77245.1 - 6.2 7.2 13.7 9.7 6.6 0.3 2.4 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance DUF4704 PF15787.5 VDK77256.1 - 1.4e-84 283.7 0.2 1.4e-84 283.7 0.2 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 VDK77256.1 - 2.3e-10 40.8 0.0 4.6e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1797 PF08796.10 VDK77258.1 - 0.066 13.3 0.1 0.29 11.2 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1797) IPPT PF01715.17 VDK77259.1 - 6.6e-58 196.2 0.6 1.2e-57 195.4 0.6 1.4 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 VDK77259.1 - 1e-06 28.3 0.0 3.1e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Isopentenyl transferase zf-C2H2_jaz PF12171.8 VDK77259.1 - 7.1e-05 23.0 0.3 0.00022 21.4 0.0 2.1 2 0 0 2 2 1 1 Zinc-finger double-stranded RNA-binding AAA_33 PF13671.6 VDK77259.1 - 0.00041 20.5 0.4 0.0081 16.3 0.1 2.7 2 1 0 2 2 2 1 AAA domain zf-met PF12874.7 VDK77259.1 - 0.00055 20.2 0.4 0.0017 18.7 0.4 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type AAA_18 PF13238.6 VDK77259.1 - 0.00056 20.5 2.0 0.56 10.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 VDK77259.1 - 0.011 15.5 0.2 0.033 13.9 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein zf-U1 PF06220.12 VDK77259.1 - 0.019 14.7 2.5 0.032 14.0 0.4 2.3 2 0 0 2 2 2 0 U1 zinc finger PhoH PF02562.16 VDK77259.1 - 0.026 14.0 0.3 0.24 10.8 0.1 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 VDK77259.1 - 0.15 12.3 3.1 0.39 11.0 0.2 2.9 2 2 0 2 2 2 0 AAA domain zf-C2H2_2 PF12756.7 VDK77259.1 - 0.4 11.1 4.7 0.47 10.8 0.5 3.1 3 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) CEBP_ZZ PF16366.5 VDK77259.1 - 0.63 10.3 3.4 7 7.0 0.2 2.6 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain NIDO PF06119.14 VDK77265.1 - 3.4e-30 104.8 1.9 6.8e-16 59.0 0.6 3.2 3 0 0 3 3 3 2 Nidogen-like EGF_3 PF12947.7 VDK77265.1 - 3.6e-08 33.4 4.1 3.6e-08 33.4 4.1 3.6 3 2 0 3 3 3 2 EGF domain EGF_CA PF07645.15 VDK77265.1 - 7.9e-07 29.2 7.4 7.9e-07 29.2 7.4 3.9 3 1 1 4 4 4 1 Calcium-binding EGF domain cEGF PF12662.7 VDK77265.1 - 1e-05 25.3 11.8 0.0047 16.8 2.8 3.1 2 0 0 2 2 2 2 Complement Clr-like EGF-like Tweety PF04906.13 VDK77265.1 - 0.12 11.0 0.2 0.19 10.4 0.2 1.2 1 0 0 1 1 1 0 Tweety SNF2_N PF00176.23 VDK77271.1 - 2.3e-15 56.2 0.0 4.7e-08 32.1 0.0 2.3 1 1 1 2 2 2 2 SNF2 family N-terminal domain HARP PF07443.13 VDK77271.1 - 2.6e-12 46.2 1.0 6e-12 45.0 0.1 2.2 2 0 0 2 2 2 1 HepA-related protein (HARP) Helicase_C PF00271.31 VDK77271.1 - 4e-11 43.2 0.0 1.2e-10 41.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Tmemb_185A PF10269.9 VDK77278.1 - 7.3e-55 186.4 21.0 1e-54 185.9 21.0 1.2 1 0 0 1 1 1 1 Transmembrane Fragile-X-F protein DUF4059 PF13268.6 VDK77278.1 - 0.0067 16.8 2.6 0.0067 16.8 2.6 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4059) MHYT PF03707.16 VDK77278.1 - 0.55 10.4 11.1 1.7 8.8 1.8 3.6 3 0 0 3 3 3 0 Bacterial signalling protein N terminal repeat DnaJ PF00226.31 VDK77279.1 - 2.2e-11 43.7 0.0 4.4e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 VDK77279.1 - 6.1e-05 22.7 2.2 0.00013 21.6 2.2 1.6 1 0 0 1 1 1 1 CSL zinc finger Sgf11 PF08209.11 VDK77279.1 - 0.11 12.1 1.0 0.23 11.1 1.0 1.6 1 1 0 1 1 1 0 Sgf11 (transcriptional regulation protein) A2L_zn_ribbon PF08792.10 VDK77279.1 - 0.16 11.7 4.2 2.6 7.9 4.2 2.5 1 1 0 1 1 1 0 A2L zinc ribbon domain Roc PF08477.13 VDK77280.1 - 6.6e-07 29.6 0.0 2e-06 28.0 0.0 1.8 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK77280.1 - 1.3e-06 28.1 0.0 1e-05 25.2 0.0 2.0 1 1 0 1 1 1 1 Ras family Beta-lactamase PF00144.24 VDK77281.1 - 7.7e-58 196.3 0.0 1.2e-57 195.7 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase ABC_membrane PF00664.23 VDK77282.1 - 1.9e-67 227.8 45.2 6.6e-40 137.5 11.2 2.7 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 VDK77282.1 - 2.9e-50 170.3 1.1 8.1e-28 97.7 0.0 3.1 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 VDK77282.1 - 9.9e-11 41.5 0.1 2.4e-05 23.9 0.0 3.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 VDK77282.1 - 1e-06 28.8 0.5 0.068 13.3 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 VDK77282.1 - 5.2e-05 23.7 0.1 0.63 10.4 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 VDK77282.1 - 7.2e-05 22.5 1.3 0.13 12.0 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 VDK77282.1 - 0.00016 21.6 3.0 0.29 10.9 0.0 3.5 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 VDK77282.1 - 0.00017 21.6 2.0 0.047 13.6 0.1 2.9 3 0 0 3 3 3 1 RsgA GTPase DUF815 PF05673.13 VDK77282.1 - 0.0013 17.9 0.1 0.25 10.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) T2SSE PF00437.20 VDK77282.1 - 0.0018 17.4 0.0 1.2 8.1 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein NB-ARC PF00931.22 VDK77282.1 - 0.0082 15.3 0.3 0.19 10.9 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.6 VDK77282.1 - 0.018 14.8 0.2 11 5.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 VDK77282.1 - 0.028 13.7 0.3 1.9 7.7 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 VDK77282.1 - 0.031 14.5 2.4 13 6.1 0.4 3.3 2 1 0 2 2 2 0 AAA domain FAD_binding_1 PF00667.20 VDK77282.1 - 0.032 13.8 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain cobW PF02492.19 VDK77282.1 - 0.062 12.9 1.5 2.5 7.7 0.1 3.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 VDK77282.1 - 0.088 12.3 0.1 4.2 6.8 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 VDK77282.1 - 0.12 12.5 10.7 0.32 11.1 0.1 3.2 3 0 0 3 3 3 0 Helicase HerA, central domain SPX PF03105.19 VDK77282.1 - 0.13 12.2 2.9 0.19 11.6 2.9 1.1 1 0 0 1 1 1 0 SPX domain IstB_IS21 PF01695.17 VDK77282.1 - 0.53 10.0 6.6 8.2 6.1 0.0 4.5 5 0 0 5 5 5 0 IstB-like ATP binding protein AAA_15 PF13175.6 VDK77282.1 - 0.58 9.8 6.6 2.7 7.6 0.1 2.9 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.23 VDK77282.1 - 1.5 8.8 12.9 0.04 14.0 1.4 3.1 3 0 0 3 3 3 0 Dynamin family RhoGAP PF00620.27 VDK77288.1 - 6.3e-45 152.7 0.0 1.3e-44 151.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain SH3_1 PF00018.28 VDK77288.1 - 0.0094 15.5 0.1 0.028 14.0 0.1 1.8 1 1 0 1 1 1 1 SH3 domain Sipho_tail PF05709.11 VDK77288.1 - 0.054 12.9 0.2 0.25 10.7 0.2 1.9 1 1 0 1 1 1 0 Phage tail protein PutA_N PF18083.1 VDK77288.1 - 0.08 13.0 0.0 5.7 7.0 0.0 3.4 4 0 0 4 4 4 0 Proline utilization A N-terminal domain SH3_2 PF07653.17 VDK77288.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain ShK PF01549.24 VDK77290.1 - 2.2e-20 72.9 69.8 0.00013 22.4 5.3 5.2 5 0 0 5 5 5 5 ShK domain-like Imm40 PF15569.6 VDK77290.1 - 0.19 11.9 2.3 1.1 9.5 0.1 2.7 3 0 0 3 3 3 0 Immunity protein 40 RRM_1 PF00076.22 VDK77291.1 - 5.1e-36 122.3 0.0 2.8e-17 62.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 VDK77291.1 - 2e-23 83.2 0.7 4.7e-23 82.1 0.0 2.0 2 0 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 VDK77291.1 - 0.023 14.5 0.0 2 8.4 0.0 3.2 3 0 0 3 3 3 0 Occluded RNA-recognition motif RRM_5 PF13893.6 VDK77291.1 - 0.18 11.4 0.0 1.4 8.5 0.0 2.1 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 VDK77291.1 - 0.22 11.7 0.0 0.48 10.7 0.0 1.5 1 0 0 1 1 1 0 RRM-like domain Presenilin PF01080.17 VDK77291.1 - 0.71 8.6 15.4 1.1 8.0 15.4 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 VDK77291.1 - 1.6 7.9 5.8 2.3 7.4 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 VDK77291.1 - 7.7 4.9 18.0 11 4.4 18.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF936 PF06075.12 VDK77291.1 - 8.7 5.1 28.0 12 4.7 28.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) CAP_N PF01213.19 VDK77293.1 - 1.7 8.0 6.7 2.7 7.4 6.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 VDK77293.1 - 4.4 7.3 9.3 2.9 7.9 4.4 2.0 2 0 0 2 2 2 0 Mitochondrial fission regulator Myosin_head PF00063.21 VDK77310.1 - 7.2e-23 80.7 0.1 7.7e-23 80.6 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) DUF3309 PF11752.8 VDK77312.1 - 0.0019 18.2 0.1 0.0035 17.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3309) Baculo_11_kDa PF06143.11 VDK77312.1 - 0.049 13.2 1.9 0.11 12.1 1.9 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Cyclin_C PF02984.19 VDK77313.1 - 5.4e-24 84.6 0.2 1.4e-23 83.3 0.2 1.7 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 VDK77313.1 - 6.8e-21 74.3 0.7 5.7e-20 71.4 0.1 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_N PF00134.23 VDK77314.1 - 2.3e-05 24.2 1.8 0.00062 19.5 1.8 2.3 1 1 0 1 1 1 1 Cyclin, N-terminal domain IHHNV_capsid PF16530.5 VDK77314.1 - 0.051 12.7 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 Infectious hypodermal and haematopoietic necrosis virus, capsid Saf_2TM PF18303.1 VDK77316.1 - 0.15 11.6 2.2 1.4 8.5 0.3 2.3 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Colicin_V PF02674.16 VDK77316.1 - 0.25 11.3 3.8 0.63 10.0 1.3 2.1 1 1 1 2 2 2 0 Colicin V production protein TMCO5 PF14992.6 VDK77316.1 - 0.58 9.7 2.1 2.5 7.6 0.1 2.1 2 0 0 2 2 2 0 TMCO5 family Tubulin PF00091.25 VDK77317.1 - 4e-63 213.2 0.0 5.5e-63 212.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK77317.1 - 3.7e-48 162.8 0.0 7.1e-48 161.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK77317.1 - 0.0068 16.1 0.0 0.012 15.3 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 VDK77317.1 - 0.15 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Raptor_N PF14538.6 VDK77318.1 - 3.6e-67 224.9 0.0 7.2e-67 223.9 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 VDK77318.1 - 1.2e-06 29.1 0.5 2.2 9.3 0.0 5.5 4 0 0 4 4 4 2 WD domain, G-beta repeat HEAT PF02985.22 VDK77318.1 - 0.00063 19.8 0.0 0.0057 16.8 0.0 2.7 2 0 0 2 2 2 1 HEAT repeat ANAPC4_WD40 PF12894.7 VDK77318.1 - 0.0035 17.6 0.0 0.26 11.6 0.0 3.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.6 VDK77318.1 - 0.041 14.3 1.9 0.1 13.0 0.6 2.4 2 0 0 2 2 2 0 HEAT repeats CbtA_toxin PF06755.12 VDK77318.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 CbtA_toxin of type IV toxin-antitoxin system MMR_HSR1 PF01926.23 VDK77321.1 - 9.5e-18 64.3 0.0 1.9e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK77321.1 - 2e-09 37.2 0.1 3.3e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 VDK77321.1 - 3.5e-08 33.2 0.0 3.2e-07 30.1 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK77321.1 - 9.3e-07 28.9 2.2 0.028 14.3 0.1 2.9 2 1 1 3 3 3 2 RsgA GTPase Dynamin_N PF00350.23 VDK77321.1 - 0.0039 17.3 0.4 3.6 7.6 0.2 2.5 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 VDK77321.1 - 0.011 15.1 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 VDK77321.1 - 0.013 15.7 0.2 0.28 11.4 0.1 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 VDK77321.1 - 0.014 15.9 0.1 0.19 12.3 0.0 2.5 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 VDK77321.1 - 0.02 15.1 0.0 0.062 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 VDK77321.1 - 0.068 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 VDK77321.1 - 0.11 12.2 0.0 22 4.8 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 VDK77321.1 - 0.14 11.7 0.1 4.5 6.8 0.0 2.2 2 0 0 2 2 2 0 Ras family DUF2465 PF10239.9 VDK77325.1 - 1e-79 268.2 0.5 1.3e-79 267.8 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) zf-met2 PF12907.7 VDK77328.1 - 0.00013 22.1 0.5 0.00029 20.9 0.5 1.6 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 VDK77328.1 - 0.00013 22.8 7.1 0.00022 22.0 7.1 1.3 1 0 0 1 1 1 1 4F5 protein family DUF629 PF04780.12 VDK77328.1 - 0.0071 14.9 0.5 0.0078 14.8 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF629) zf-MYST PF17772.1 VDK77328.1 - 0.086 12.5 3.5 0.092 12.4 0.8 2.1 2 0 0 2 2 2 0 MYST family zinc finger domain zf-C2H2_4 PF13894.6 VDK77328.1 - 0.27 12.2 1.4 0.27 12.2 1.4 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger 4F5 PF04419.14 VDK77330.1 - 1e-09 39.1 7.8 1.7e-09 38.4 7.8 1.3 1 0 0 1 1 1 1 4F5 protein family zf-met2 PF12907.7 VDK77330.1 - 0.062 13.4 7.0 1.8 8.8 0.2 2.3 2 0 0 2 2 2 0 Zinc-binding Ribosomal_L12 PF00542.19 VDK77331.1 - 5.7e-20 71.4 7.2 8.9e-20 70.8 5.8 2.0 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 VDK77331.1 - 1.8e-07 30.7 0.1 1.8e-07 30.7 0.1 2.9 3 0 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain DUF4479 PF14794.6 VDK77331.1 - 0.025 14.4 1.2 0.14 12.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) CfAFP PF05264.11 VDK77331.1 - 0.095 12.7 0.9 0.16 11.9 0.9 1.3 1 0 0 1 1 1 0 Choristoneura fumiferana antifreeze protein (CfAFP) KH_1 PF00013.29 VDK77331.1 - 0.14 12.0 0.7 0.27 11.1 0.7 1.5 1 0 0 1 1 1 0 KH domain zf-HC5HC2H_2 PF13832.6 VDK77332.1 - 1.3e-33 115.5 8.7 1.3e-33 115.5 8.7 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 VDK77332.1 - 1.8e-23 82.6 6.0 1.8e-23 82.6 6.0 3.2 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.25 VDK77332.1 - 1.9e-22 79.1 0.2 4.7e-22 77.9 0.2 1.7 1 0 0 1 1 1 1 Bromodomain PHD_2 PF13831.6 VDK77332.1 - 2.1e-15 56.0 4.0 2.1e-15 56.0 4.0 2.8 2 0 0 2 2 2 1 PHD-finger EPL1 PF10513.9 VDK77332.1 - 1.8e-14 54.4 0.2 5.2e-14 52.9 0.2 1.8 1 0 0 1 1 1 1 Enhancer of polycomb-like PHD PF00628.29 VDK77332.1 - 2.4e-10 40.2 23.2 1.2e-08 34.7 9.6 2.9 2 0 0 2 2 2 2 PHD-finger Cullin PF00888.22 VDK77332.1 - 0.063 11.9 0.1 0.1 11.1 0.1 1.3 1 0 0 1 1 1 0 Cullin family C1_1 PF00130.22 VDK77332.1 - 0.69 9.9 27.2 0.022 14.6 5.7 3.1 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 VDK77332.1 - 2.4 8.5 24.0 0.044 14.1 7.6 2.9 2 0 0 2 2 2 0 RING-like domain C1_2 PF03107.16 VDK77332.1 - 4.2 7.8 23.4 0.091 13.1 2.5 3.2 3 1 0 3 3 3 0 C1 domain Rad21_Rec8_N PF04825.13 VDK77333.1 - 1.1e-39 135.0 0.1 2e-39 134.1 0.1 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 VDK77333.1 - 4.9e-18 64.2 0.1 2e-17 62.2 0.0 2.0 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein SMC_ScpA PF02616.14 VDK77333.1 - 0.0043 17.0 0.0 0.0098 15.8 0.0 1.5 1 0 0 1 1 1 1 Segregation and condensation protein ScpA Ras PF00071.22 VDK77345.1 - 1.6e-46 157.9 0.0 1.8e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK77345.1 - 2.7e-16 59.9 0.0 3.8e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK77345.1 - 8.1e-07 28.6 0.0 9.8e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK77345.1 - 8.2e-07 28.8 0.0 2.1e-06 27.4 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK77345.1 - 1.9e-05 24.7 0.0 0.00025 21.0 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 VDK77345.1 - 0.00015 21.9 0.0 0.00024 21.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase adh_short PF00106.25 VDK77346.1 - 1.6e-33 115.8 0.0 2.3e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK77346.1 - 2.1e-13 50.4 0.0 2.9e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK77346.1 - 0.00079 19.4 0.1 0.003 17.5 0.0 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 VDK77346.1 - 0.0074 15.8 0.1 0.013 14.9 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PdxJ PF03740.13 VDK77346.1 - 0.04 13.0 0.3 0.058 12.5 0.3 1.2 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ 3HCDH_N PF02737.18 VDK77346.1 - 0.044 13.7 0.0 0.098 12.5 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.25 VDK77347.1 - 6e-68 229.1 0.0 8.2e-68 228.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77347.1 - 2.5e-33 115.4 0.0 3.2e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 VDK77347.1 - 5.9e-10 39.7 1.0 2.1e-09 37.9 1.0 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 VDK77347.1 - 1.2e-05 24.8 0.0 2.8e-05 23.6 0.0 1.6 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 VDK77347.1 - 0.00019 21.2 0.0 0.54 9.8 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 VDK77347.1 - 0.00031 19.6 0.0 0.0005 19.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK77347.1 - 0.026 13.9 0.2 0.077 12.3 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 VDK77347.1 - 0.077 12.0 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 VDK77347.1 - 0.099 11.6 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain CRAL_TRIO PF00650.20 VDK77348.1 - 1e-22 80.5 0.0 1.4e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 VDK77348.1 - 6.9e-06 26.3 0.0 9.8e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Herpes_BLRF2 PF05812.12 VDK77348.1 - 0.2 11.8 0.0 0.31 11.2 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Motile_Sperm PF00635.26 VDK77350.1 - 9.5e-16 57.6 0.1 1.7e-15 56.8 0.1 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain SMAP PF15477.6 VDK77351.1 - 5.6e-16 59.3 0.6 1e-15 58.5 0.6 1.4 1 0 0 1 1 1 1 Small acidic protein family SelR PF01641.18 VDK77353.1 - 3.6e-52 175.6 0.4 4.2e-52 175.3 0.4 1.1 1 0 0 1 1 1 1 SelR domain Zn_ribbon_SprT PF17283.2 VDK77353.1 - 0.0057 16.5 0.3 2.2 8.2 0.1 2.3 2 0 0 2 2 2 2 SprT-like zinc ribbon domain Yippee-Mis18 PF03226.14 VDK77353.1 - 0.027 14.7 4.4 0.054 13.7 4.4 1.5 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Ribosomal_L37e PF01907.19 VDK77353.1 - 0.065 13.4 5.0 0.21 11.8 1.5 2.2 2 0 0 2 2 2 0 Ribosomal protein L37e HECT_2 PF09814.9 VDK77353.1 - 0.15 10.9 2.7 0.4 9.5 0.1 2.0 1 1 0 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding LicD PF04991.13 VDK77354.1 - 0.0045 17.2 0.6 0.13 12.4 0.5 3.0 2 1 0 3 3 3 1 LicD family Abi_HHR PF07815.14 VDK77356.1 - 2.7e-27 94.7 0.3 5.7e-27 93.7 0.3 1.6 1 0 0 1 1 1 1 Abl-interactor HHR SH3_9 PF14604.6 VDK77356.1 - 1.4e-16 60.0 0.3 2.5e-16 59.3 0.3 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK77356.1 - 1.1e-13 50.6 0.0 1.9e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK77356.1 - 7e-10 38.4 0.0 1.6e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Pkinase PF00069.25 VDK77358.1 - 5.3e-61 206.3 0.0 8.8e-61 205.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77358.1 - 9.2e-45 152.9 0.0 1.4e-44 152.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 VDK77358.1 - 3.8e-17 62.5 5.0 5.8e-16 58.6 4.0 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Kdo PF06293.14 VDK77358.1 - 8.4e-05 22.0 0.0 0.00017 21.0 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK77358.1 - 9.9e-05 21.8 0.0 0.00023 20.6 0.0 1.6 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 VDK77358.1 - 0.01 15.5 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 VDK77358.1 - 0.014 14.2 0.0 0.048 12.4 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Y_phosphatase PF00102.27 VDK77359.1 - 2.2e-76 256.5 0.2 3.1e-76 256.1 0.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PDZ PF00595.24 VDK77359.1 - 1.8e-19 69.8 0.0 3.4e-19 69.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Y_phosphatase3 PF13350.6 VDK77359.1 - 5.3e-05 23.3 0.0 8.3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PDZ_6 PF17820.1 VDK77359.1 - 0.00054 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DSPc PF00782.20 VDK77359.1 - 0.00088 19.1 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 VDK77359.1 - 0.098 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Dicty_REP PF05086.12 VDK77360.1 - 1.8 6.5 11.5 2.3 6.1 11.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AMP-binding PF00501.28 VDK77371.1 - 8.3e-59 199.3 0.7 9.7e-25 87.0 0.3 3.1 1 1 2 3 3 3 3 AMP-binding enzyme AMP-binding_C PF13193.6 VDK77371.1 - 8.1e-11 42.7 0.0 2e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Translin PF01997.16 VDK77372.1 - 8.9e-44 149.9 0.4 2.2e-36 125.8 0.0 2.1 2 0 0 2 2 2 2 Translin family AbiH PF14253.6 VDK77372.1 - 0.069 13.0 0.2 0.18 11.6 0.2 1.8 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH Cgr1 PF03879.14 VDK77373.1 - 1.7e-12 47.7 32.8 2.4e-12 47.2 32.8 1.1 1 0 0 1 1 1 1 Cgr1 family Stn1 PF10451.9 VDK77373.1 - 0.22 10.4 8.3 0.66 8.9 6.0 2.1 2 0 0 2 2 2 0 Telomere regulation protein Stn1 MCU PF04678.13 VDK77373.1 - 1.3 9.1 6.1 1.6 8.8 6.1 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter OSCP PF00213.18 VDK77375.1 - 1e-13 51.8 0.1 1.3e-13 51.5 0.1 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit HTH_17 PF12728.7 VDK77375.1 - 0.13 12.5 0.1 0.46 10.7 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain SpoIIID PF12116.8 VDK77375.1 - 0.15 12.2 0.3 6.4 7.0 0.0 2.3 1 1 1 2 2 2 0 Stage III sporulation protein D DNA_pol_lambd_f PF10391.9 VDK77375.1 - 0.24 11.2 0.8 1.1 9.2 0.3 2.3 2 1 0 2 2 2 0 Fingers domain of DNA polymerase lambda UPA PF17217.3 VDK77378.1 - 0.089 12.7 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 UPA domain OSCP PF00213.18 VDK77380.1 - 4e-20 72.6 0.1 4.3e-20 72.5 0.1 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit T6PP_N PF18572.1 VDK77380.1 - 0.1 12.4 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain TPD52 PF04201.15 VDK77380.1 - 0.17 11.5 1.9 0.63 9.6 0.1 1.9 1 1 1 2 2 2 0 Tumour protein D52 family Jiraiya PF15038.6 VDK77381.1 - 3.1e-39 134.1 14.6 3.7e-39 133.8 14.6 1.1 1 0 0 1 1 1 1 Jiraiya Saf_2TM PF18303.1 VDK77381.1 - 4.9 6.7 9.2 1.1 8.8 4.4 2.0 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DLIC PF05783.11 VDK77382.1 - 6.8e-75 252.7 6.4 6.4e-73 246.2 1.8 2.8 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) AAA_14 PF13173.6 VDK77382.1 - 0.016 15.3 0.0 0.032 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 VDK77382.1 - 0.019 15.3 0.7 0.16 12.4 0.0 2.6 3 0 0 3 3 3 0 AAA ATPase domain G-alpha PF00503.20 VDK77382.1 - 0.069 12.3 1.2 3.2 6.8 0.0 2.6 3 0 0 3 3 3 0 G-protein alpha subunit AAA_22 PF13401.6 VDK77382.1 - 0.16 12.2 0.1 1.1 9.5 0.0 2.3 2 1 0 2 2 2 0 AAA domain GET2 PF08690.10 VDK77382.1 - 0.33 10.6 4.3 0.48 10.0 4.3 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 TUDOR PF00567.24 VDK77385.1 - 1.8e-07 31.2 0.0 0.022 14.8 0.0 3.5 2 1 1 3 3 3 3 Tudor domain BLM10_N PF16547.5 VDK77385.1 - 0.1 12.9 0.1 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 Proteasome-substrate-size regulator, N-terminal Peptidase_C54 PF03416.19 VDK77389.1 - 4.6e-71 239.5 0.0 1.4e-42 146.1 0.0 2.1 1 1 1 2 2 2 2 Peptidase family C54 Tmemb_161AB PF10268.9 VDK77390.1 - 4.2e-79 266.4 23.2 2.1e-78 264.1 23.2 1.8 1 1 0 1 1 1 1 Predicted transmembrane protein 161AB Collagen PF01391.18 VDK77394.1 - 2.7e-23 81.5 107.4 3e-10 39.7 37.5 4.1 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK77394.1 - 1.5e-19 69.8 0.5 1.8e-19 69.5 0.5 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain MLANA PF14991.6 VDK77395.1 - 0.022 15.0 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A VPS28 PF03997.12 VDK77396.1 - 2.2e-59 200.3 2.2 3.3e-59 199.8 2.2 1.2 1 0 0 1 1 1 1 VPS28 protein Ribosomal_S27e PF01667.17 VDK77396.1 - 1.1e-25 89.1 6.8 1.1e-25 89.1 6.8 2.2 2 0 0 2 2 2 1 Ribosomal protein S27 DevR PF01905.16 VDK77396.1 - 0.075 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 COX4 PF02936.14 VDK77398.1 - 3.6e-29 101.5 0.1 5e-29 101.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV 3-alpha PF03475.14 VDK77398.1 - 0.077 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 3-alpha domain Pkinase_Tyr PF07714.17 VDK77412.1 - 1.4e-49 168.7 0.1 2e-49 168.2 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK77412.1 - 4.9e-24 85.1 0.0 7e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F5_F8_type_C PF00754.25 VDK77412.1 - 5.5e-20 71.8 0.0 1.5e-16 60.7 0.0 2.7 2 0 0 2 2 2 2 F5/8 type C domain Kinase-like PF14531.6 VDK77412.1 - 0.011 15.1 0.4 0.05 12.9 0.4 1.9 1 1 0 1 1 1 0 Kinase-like DUF4834 PF16118.5 VDK77412.1 - 0.16 13.0 0.0 0.37 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ribosomal_S7 PF00177.21 VDK77422.1 - 4.8e-35 120.4 0.5 6.6e-35 119.9 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e SepSecS PF05889.13 VDK77424.1 - 1.8e-122 408.8 0.0 2.2e-122 408.5 0.0 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 VDK77424.1 - 0.0023 17.2 0.0 0.0033 16.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 VDK77424.1 - 0.14 10.8 0.0 0.2 10.3 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain DUF423 PF04241.15 VDK77425.1 - 1.1e-18 67.1 0.1 1.8e-18 66.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Spectrin PF00435.21 VDK77428.1 - 0 1296.1 231.3 1.4e-25 89.8 7.5 22.1 21 1 1 22 22 22 20 Spectrin repeat EFhand_Ca_insen PF08726.10 VDK77428.1 - 2.9e-27 94.5 3.0 1.6e-25 89.0 0.1 4.2 4 0 0 4 4 4 1 Ca2+ insensitive EF hand SH3_1 PF00018.28 VDK77428.1 - 3.9e-16 58.4 0.0 1.3e-15 56.7 0.0 2.0 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK77428.1 - 1.2e-11 44.3 0.0 3e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK77428.1 - 2.9e-09 36.5 0.0 8.8e-09 34.9 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain EF-hand_1 PF00036.32 VDK77428.1 - 3.1e-09 35.7 0.3 0.00049 19.5 0.0 3.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 VDK77428.1 - 3.2e-08 33.9 0.1 3.2e-08 33.9 0.1 4.4 5 0 0 5 5 3 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK77428.1 - 6e-07 28.9 0.1 0.021 14.7 0.1 3.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 VDK77428.1 - 7.3e-05 22.5 1.1 0.027 14.3 0.0 4.0 3 1 1 4 4 4 1 EF-hand domain pair SH3_10 PF17902.1 VDK77428.1 - 0.0017 18.4 0.0 0.0063 16.6 0.0 2.0 1 0 0 1 1 1 1 SH3 domain Lyase_aromatic PF00221.19 VDK77428.1 - 0.0069 15.1 0.1 0.029 13.1 0.0 2.1 2 0 0 2 2 2 1 Aromatic amino acid lyase GvpG PF05120.12 VDK77428.1 - 0.0072 16.3 12.8 0.39 10.8 0.1 5.6 4 0 0 4 4 3 1 Gas vesicle protein G DUF4478 PF14793.6 VDK77428.1 - 0.12 12.3 1.3 12 5.9 0.0 3.6 3 0 0 3 3 3 0 Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases GlcNAc-1_reg PF18440.1 VDK77428.1 - 0.25 11.6 1.5 2.5 8.4 0.1 3.1 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain zf-MIZ PF02891.20 VDK77428.1 - 0.71 9.7 3.7 10 6.0 0.4 2.6 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger DUF5616 PF18481.1 VDK77428.1 - 5.1 7.4 9.7 32 4.8 0.0 6.1 7 0 0 7 7 6 0 Domain of unknown function (DUF5616) DUF630 PF04783.12 VDK77428.1 - 5.4 7.3 5.8 67 3.8 0.4 4.1 3 0 0 3 3 3 0 Protein of unknown function (DUF630) CnrY PF17524.2 VDK77428.1 - 10 6.5 6.0 1e+02 3.2 0.1 4.4 4 0 0 4 4 4 0 Anti-sigma factor CnrY RdRP PF05183.12 VDK77429.1 - 4.7e-145 484.5 0.0 6.4e-145 484.1 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase CUE PF02845.16 VDK77429.1 - 0.00039 20.0 0.1 0.00092 18.9 0.1 1.6 1 0 0 1 1 1 1 CUE domain PLN_propep PF16485.5 VDK77429.1 - 0.037 13.7 0.0 0.093 12.5 0.0 1.7 1 0 0 1 1 1 0 Protealysin propeptide UBA_4 PF14555.6 VDK77429.1 - 0.25 11.2 1.3 0.37 10.7 0.1 2.0 2 0 0 2 2 2 0 UBA-like domain DUF5326 PF17260.2 VDK77433.1 - 0.83 9.8 9.4 0.16 12.2 0.3 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5326) Pkinase PF00069.25 VDK77445.1 - 2.2e-29 102.6 0.1 2.8e-29 102.3 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77445.1 - 4.2e-16 59.0 0.1 5.6e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK77445.1 - 4.8e-06 25.6 0.1 6.8e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK77445.1 - 0.0072 15.7 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK77445.1 - 0.14 12.0 0.0 1.3 8.8 0.0 2.1 2 1 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 VDK77446.1 - 4.2e-61 201.5 26.4 3.8e-09 37.0 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK77446.1 - 1.2e-23 83.1 3.0 0.00047 20.4 0.0 6.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 VDK77446.1 - 1.3e-13 50.5 10.2 0.036 12.7 0.0 5.9 1 1 5 6 6 6 5 Nucleoporin Nup120/160 eIF2A PF08662.11 VDK77446.1 - 9.5e-12 45.2 0.2 2.2e-07 30.9 0.0 3.3 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 VDK77446.1 - 7.2e-09 35.0 10.1 0.14 11.1 0.5 4.4 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 VDK77446.1 - 1.5e-07 31.1 0.2 0.0013 18.2 0.0 3.8 2 1 2 4 4 4 3 WD40-like domain PALB2_WD40 PF16756.5 VDK77446.1 - 0.00015 20.8 4.1 0.32 9.9 1.6 4.5 1 1 1 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 VDK77446.1 - 0.00045 18.7 0.1 0.0084 14.5 0.0 2.2 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 VDK77446.1 - 0.0015 17.1 0.0 0.024 13.2 0.0 2.5 1 1 1 2 2 2 1 Cytochrome D1 heme domain Big_7 PF17957.1 VDK77446.1 - 0.0078 17.0 1.8 0.84 10.4 0.4 3.0 2 1 0 2 2 2 1 Bacterial Ig domain VID27 PF08553.10 VDK77446.1 - 0.017 14.2 0.0 0.049 12.7 0.0 1.8 1 1 0 1 1 1 0 VID27 C-terminal WD40-like domain Arylsulfotran_2 PF14269.6 VDK77446.1 - 0.018 14.4 0.8 0.026 13.9 0.2 1.6 2 0 0 2 2 2 0 Arylsulfotransferase (ASST) SBD PF17882.1 VDK77446.1 - 0.046 13.5 0.1 11 5.8 0.0 2.6 2 0 0 2 2 2 0 OAA-family lectin sugar binding domain Kelch_6 PF13964.6 VDK77446.1 - 0.11 12.9 5.4 2.9 8.3 0.1 4.3 3 2 1 4 4 4 0 Kelch motif Hira PF07569.11 VDK77446.1 - 0.19 11.5 4.7 6.9 6.3 0.0 4.5 5 1 1 6 6 6 0 TUP1-like enhancer of split RNA_pol_Rpb1_5 PF04998.17 VDK77447.1 - 9.9e-87 290.7 1.0 1.9e-86 289.8 1.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 VDK77447.1 - 5e-83 279.0 0.5 5e-83 279.0 0.5 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 VDK77447.1 - 4.9e-74 248.1 0.0 1e-73 247.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 VDK77447.1 - 8.5e-39 133.0 0.0 2.3e-38 131.6 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 VDK77447.1 - 2.1e-29 101.6 0.0 5.5e-29 100.3 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 HhH-GPD PF00730.25 VDK77448.1 - 2.2e-20 73.1 0.0 3.1e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 VDK77448.1 - 6.6e-09 35.2 0.0 1e-07 31.4 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 VDK77448.1 - 0.039 14.6 0.1 11 6.8 0.0 2.5 1 1 2 3 3 3 0 Helix-hairpin-helix domain HD_3 PF13023.6 VDK77449.1 - 1.3e-44 152.0 0.9 1.8e-44 151.6 0.9 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 VDK77449.1 - 3.2e-14 53.1 0.5 5.9e-14 52.2 0.5 1.4 1 1 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 VDK77449.1 - 3.5e-06 27.2 0.6 1.3e-05 25.5 0.6 1.8 1 1 0 1 1 1 1 HD domain RNA_polI_A34 PF08208.11 VDK77450.1 - 0.097 12.8 0.2 4 7.5 0.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Band_7 PF01145.25 VDK77451.1 - 1.3e-23 84.0 0.3 1.8e-23 83.5 0.3 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 VDK77451.1 - 0.0016 18.2 0.1 0.0024 17.6 0.1 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family DUF5405 PF17399.2 VDK77451.1 - 0.071 13.4 0.2 0.2 11.9 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5405) pPIWI_RE_REase PF18154.1 VDK77451.1 - 0.11 12.4 0.5 0.22 11.5 0.4 1.5 1 1 0 1 1 1 0 REase associating with pPIWI_RE 7tm_1 PF00001.21 VDK77453.1 - 1.1e-06 28.2 4.9 1.5e-06 27.7 4.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 VDK77453.1 - 0.0074 15.4 1.5 0.012 14.8 1.5 1.3 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) FAA_hydro_N_2 PF18288.1 VDK77454.1 - 0.74 10.3 6.0 1.2 9.7 0.7 3.4 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 EspB_PE PF18625.1 VDK77454.1 - 1.1 9.7 8.7 2.3 8.7 0.0 3.9 2 1 1 3 3 3 0 ESX-1 secreted protein B PE domain CALCOCO1 PF07888.11 VDK77454.1 - 6.6 5.5 58.8 0.0067 15.3 14.5 3.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like bZIP_1 PF00170.21 VDK77455.1 - 0.0014 18.7 13.6 0.0014 18.7 13.6 2.4 2 1 0 2 2 2 1 bZIP transcription factor FAM76 PF16046.5 VDK77455.1 - 0.047 13.0 5.6 1 8.7 1.0 2.3 2 0 0 2 2 2 0 FAM76 protein TSC22 PF01166.18 VDK77455.1 - 0.12 12.7 1.1 0.38 11.1 1.1 1.9 1 0 0 1 1 1 0 TSC-22/dip/bun family NRBF2 PF08961.10 VDK77455.1 - 0.26 10.9 2.8 1.2 8.7 1.2 2.5 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator FOXP-CC PF16159.5 VDK77463.1 - 0.2 12.3 9.0 0.48 11.1 0.5 3.2 2 1 0 2 2 2 0 FOXP coiled-coil domain NOT2_3_5 PF04153.18 VDK77464.1 - 1.4e-21 77.0 2.7 2.7e-21 76.0 2.7 1.5 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family NOT2_3_5 PF04153.18 VDK77467.1 - 7.4e-29 100.5 0.2 1.6e-28 99.4 0.2 1.6 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family UPF0242 PF06785.11 VDK77469.1 - 0.0068 16.5 4.9 0.0079 16.3 4.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Borrelia_REV PF03978.13 VDK77469.1 - 0.031 14.2 3.1 0.07 13.1 3.1 1.6 1 1 0 1 1 1 0 Borrelia burgdorferi REV protein GutM PF06923.11 VDK77469.1 - 0.052 13.6 0.2 12 6.1 0.1 2.2 2 0 0 2 2 2 0 Glucitol operon activator protein (GutM) Occludin_ELL PF07303.13 VDK77469.1 - 0.49 11.1 7.1 1.1 10.0 1.5 2.1 1 1 1 2 2 2 0 Occludin homology domain wnt PF00110.19 VDK77479.1 - 4e-111 371.5 22.3 4.5e-111 371.4 22.3 1.0 1 0 0 1 1 1 1 wnt family Guanylate_cyc PF00211.20 VDK77480.1 - 1.8e-54 184.1 0.1 3.6e-54 183.2 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 VDK77480.1 - 3.2e-41 141.2 4.2 2.2e-40 138.4 4.2 2.1 1 1 0 1 1 1 1 Heme NO binding associated HNOB PF07700.15 VDK77480.1 - 1.6e-30 106.3 0.3 2.8e-30 105.4 0.3 1.5 1 0 0 1 1 1 1 Haem-NO-binding DIX PF00778.17 VDK77481.1 - 9e-21 73.5 0.1 1.7e-20 72.6 0.1 1.5 1 0 0 1 1 1 1 DIX domain PDZ PF00595.24 VDK77481.1 - 1.6e-19 70.0 0.3 3.5e-19 68.9 0.3 1.6 1 0 0 1 1 1 1 PDZ domain Dishevelled PF02377.15 VDK77481.1 - 1.3e-14 55.0 11.8 3.4e-14 53.6 11.8 1.7 1 0 0 1 1 1 1 Dishevelled specific domain DEP PF00610.21 VDK77481.1 - 1.5e-14 53.8 0.0 2.8e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDZ_6 PF17820.1 VDK77481.1 - 0.00014 21.6 0.1 0.00077 19.3 0.1 2.1 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 VDK77481.1 - 0.0026 18.0 0.1 0.006 16.9 0.1 1.6 1 0 0 1 1 1 1 PDZ domain Pkinase_Tyr PF07714.17 VDK77482.1 - 3.2e-11 43.0 0.0 2.1e-10 40.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK77482.1 - 6.7e-11 42.1 0.0 1.7e-10 40.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 VDK77482.1 - 5.5e-07 28.7 4.4 4.2e-06 25.8 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase PUA_2 PF14306.6 VDK77482.1 - 0.025 14.3 0.0 0.65 9.6 0.0 2.6 2 0 0 2 2 2 0 PUA-like domain Kdo PF06293.14 VDK77482.1 - 0.027 13.8 0.1 0.048 13.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK77482.1 - 0.23 11.4 0.0 0.35 10.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family E1-E2_ATPase PF00122.20 VDK77506.1 - 5.4e-45 153.1 3.2 1.1e-44 152.1 3.2 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 VDK77506.1 - 1.7e-39 135.5 1.7 1.7e-39 135.5 1.7 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 VDK77506.1 - 9.9e-23 81.5 0.1 4.2e-20 72.9 0.1 2.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 VDK77506.1 - 2.5e-09 37.1 0.2 0.00041 20.4 0.0 3.3 2 1 1 3 3 3 2 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 VDK77506.1 - 2.8e-05 24.0 2.9 0.0014 18.4 1.5 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDK77506.1 - 0.02 15.3 0.1 0.15 12.4 0.1 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 VDK77507.1 - 4.7e-14 51.8 0.1 6e-14 51.5 0.1 1.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Ish1 PF10281.9 VDK77507.1 - 0.09 13.1 0.1 0.21 11.9 0.0 1.6 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein MIP PF00230.20 VDK77508.1 - 7.6e-15 55.2 16.9 4.1e-14 52.8 16.9 1.9 1 1 0 1 1 1 1 Major intrinsic protein DUF2439 PF10382.9 VDK77508.1 - 0.15 12.4 2.1 0.21 11.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) SET PF00856.28 VDK77509.1 - 1.3e-22 81.0 0.2 3.4e-22 79.6 0.2 1.8 1 0 0 1 1 1 1 SET domain Ank_3 PF13606.6 VDK77509.1 - 0.00085 19.6 0.6 0.67 10.7 0.0 4.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 VDK77509.1 - 0.003 18.1 0.1 0.086 13.4 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK77509.1 - 0.017 15.7 1.7 22 5.8 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeats (many copies) TDP43_N PF18694.1 VDK77510.1 - 4.8e-22 77.6 0.0 8.6e-22 76.8 0.0 1.4 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_1 PF00076.22 VDK77510.1 - 2.4e-18 65.7 2.2 1.6e-14 53.5 0.5 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 VDK77510.1 - 0.017 15.4 0.0 0.94 9.7 0.0 2.9 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 VDK77510.1 - 0.018 15.1 0.1 0.035 14.1 0.1 1.5 1 0 0 1 1 1 0 RNA binding motif Yip1 PF04893.17 VDK77511.1 - 0.00018 21.3 0.5 0.00033 20.4 0.5 1.5 1 0 0 1 1 1 1 Yip1 domain SLATT_1 PF18181.1 VDK77511.1 - 0.1 12.5 0.5 0.94 9.4 0.1 2.2 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 YIF1 PF03878.15 VDK77511.1 - 0.11 12.0 5.8 12 5.3 5.8 2.2 1 1 0 1 1 1 0 YIF1 PNP_UDP_1 PF01048.20 VDK77512.1 - 1.1e-38 132.9 0.0 1.2e-38 132.6 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily DDHD PF02862.17 VDK77513.1 - 1.6e-38 133.2 0.9 2.4e-38 132.5 0.0 1.8 2 1 0 2 2 2 1 DDHD domain WWE PF02825.20 VDK77513.1 - 0.036 14.7 1.5 0.46 11.1 0.1 3.1 3 0 0 3 3 3 0 WWE domain AIM3 PF17096.5 VDK77513.1 - 0.33 11.9 3.7 0.88 10.6 3.7 1.7 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 TUDOR PF00567.24 VDK77514.1 - 7e-18 64.8 0.2 1.7e-07 31.3 0.0 2.6 2 0 0 2 2 2 2 Tudor domain DUF4570 PF15134.6 VDK77514.1 - 0.19 11.8 0.9 9.7 6.3 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4570) Homeodomain PF00046.29 VDK77515.1 - 2.5e-22 78.5 4.5 4.2e-22 77.8 4.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK77515.1 - 0.012 15.5 0.1 0.029 14.3 0.1 1.6 1 0 0 1 1 1 0 Homeobox KN domain WD40 PF00400.32 VDK77516.1 - 2.4e-30 104.1 12.1 0.00012 22.8 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK77516.1 - 1.7e-16 60.2 0.3 4e-05 23.8 0.0 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK77516.1 - 1.2e-09 37.9 1.1 1.4e-06 27.9 0.2 2.4 1 1 1 2 2 2 2 WD40-like domain PQQ_2 PF13360.6 VDK77516.1 - 2.5e-06 27.2 0.3 3.5e-06 26.8 0.3 1.2 1 0 0 1 1 1 1 PQQ-like domain VID27 PF08553.10 VDK77516.1 - 1e-05 24.8 0.3 0.0002 20.5 0.3 2.2 1 1 0 1 1 1 1 VID27 C-terminal WD40-like domain DUF5046 PF16465.5 VDK77516.1 - 4.9e-05 22.9 0.6 0.21 11.0 0.1 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF5046) PQQ PF01011.21 VDK77516.1 - 0.00015 21.5 0.1 1.5 8.9 0.0 4.5 4 1 0 4 4 4 1 PQQ enzyme repeat Coatomer_WDAD PF04053.14 VDK77516.1 - 0.00053 19.1 0.0 0.00078 18.6 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region Ge1_WD40 PF16529.5 VDK77516.1 - 0.0014 17.7 1.0 0.68 8.8 0.0 3.0 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 VDK77516.1 - 0.003 18.0 0.2 16 6.1 0.0 4.3 4 0 0 4 4 4 1 PQQ-like domain DUF1308 PF07000.11 VDK77517.1 - 7e-60 201.7 0.1 1.1e-59 201.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1308) DUF5614 PF18474.1 VDK77517.1 - 2.6e-26 92.3 0.1 6.4e-26 91.0 0.0 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF5614) LRR_8 PF13855.6 VDK77519.1 - 2.5e-16 59.2 12.3 9.2e-07 28.5 5.4 3.5 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 VDK77519.1 - 6.6e-13 48.6 16.7 0.00045 20.5 5.1 4.3 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 VDK77519.1 - 6.9e-06 25.7 14.3 0.16 12.1 0.0 5.2 5 0 0 5 5 5 3 Leucine Rich repeat LRR_9 PF14580.6 VDK77519.1 - 0.00056 19.5 3.7 0.058 12.9 0.2 2.5 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 VDK77519.1 - 0.0074 16.7 23.1 1.5 9.6 0.1 6.1 4 2 0 4 4 4 2 Leucine Rich Repeat Spt20 PF12090.8 VDK77540.1 - 1.2 8.8 11.5 1.2 8.7 11.5 1.1 1 0 0 1 1 1 0 Spt20 family zf-3CxxC_2 PF17180.4 VDK77542.1 - 1.1e-15 58.1 2.4 1.1e-15 58.1 2.4 1.9 2 0 0 2 2 2 1 Zinc-binding domain zf-CCHC_2 PF13696.6 VDK77542.1 - 4.4e-09 36.0 6.5 4.4e-09 36.0 6.5 2.5 3 0 0 3 3 3 1 Zinc knuckle UPF0515 PF15135.6 VDK77542.1 - 9.5e-06 25.2 3.8 1.5e-05 24.5 3.8 1.3 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 zf-C2H2_11 PF16622.5 VDK77542.1 - 0.0043 16.8 0.4 0.0043 16.8 0.4 3.0 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-3CxxC PF13695.6 VDK77542.1 - 0.021 15.3 7.5 0.021 15.3 7.5 2.3 2 1 0 2 2 2 0 Zinc-binding domain zf-CCHC PF00098.23 VDK77542.1 - 0.061 13.4 2.8 0.061 13.4 2.8 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_4 PF13894.6 VDK77542.1 - 3.6 8.7 8.0 7 7.8 0.3 3.9 2 1 1 3 3 3 0 C2H2-type zinc finger eIF_4EBP PF05456.11 VDK77544.1 - 0.049 13.6 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Trehalase PF01204.18 VDK77546.1 - 1.3e-108 364.1 1.4 2e-82 277.7 0.1 2.0 1 1 1 2 2 2 2 Trehalase Glyco_hydro_63 PF03200.16 VDK77546.1 - 0.00044 19.1 0.0 0.00083 18.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Bac_rhamnosid6H PF17389.2 VDK77546.1 - 0.0017 17.7 0.0 0.038 13.3 0.0 2.2 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain GDE_C PF06202.14 VDK77546.1 - 0.099 11.6 0.2 0.35 9.7 0.2 1.8 1 1 0 1 1 1 0 Amylo-alpha-1,6-glucosidase PAN_1 PF00024.26 VDK77548.1 - 2.4e-39 133.2 38.8 1.5e-13 50.5 6.3 4.3 4 0 0 4 4 4 4 PAN domain PAN_3 PF08277.12 VDK77548.1 - 0.00027 20.7 0.5 0.00027 20.7 0.5 5.0 6 1 0 6 6 6 2 PAN-like domain PAN_4 PF14295.6 VDK77548.1 - 0.14 12.1 0.2 0.14 12.1 0.2 4.5 4 1 0 4 4 4 0 PAN domain G-alpha PF00503.20 VDK77550.1 - 4.5e-121 404.3 1.6 5.6e-121 404.0 1.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 VDK77550.1 - 8.6e-18 64.4 0.3 6.8e-13 48.4 0.1 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK77550.1 - 0.00011 21.7 1.9 0.019 14.3 0.3 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 VDK77550.1 - 0.00057 20.1 0.2 1.2 9.4 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 VDK77550.1 - 0.0027 17.1 0.1 0.0043 16.5 0.1 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_29 PF13555.6 VDK77550.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SSF PF00474.17 VDK77554.1 - 4.4e-18 65.4 28.8 2.1e-16 59.8 20.8 2.4 1 1 1 2 2 2 2 Sodium:solute symporter family AA_permease_2 PF13520.6 VDK77555.1 - 1.4e-59 202.0 40.9 1.4e-59 202.0 40.9 1.3 2 0 0 2 2 2 1 Amino acid permease AA_permease PF00324.21 VDK77555.1 - 1.3e-31 109.8 33.7 1.3e-31 109.8 33.7 1.3 1 1 0 1 1 1 1 Amino acid permease Hep_core_N PF08290.11 VDK77555.1 - 0.18 11.8 1.7 13 5.9 0.0 3.1 2 0 0 2 2 2 0 Hepatitis core protein, putative zinc finger E1-E2_ATPase PF00122.20 VDK77556.1 - 1.9e-40 138.3 0.3 1.9e-40 138.3 0.3 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 VDK77556.1 - 1.3e-18 68.1 0.0 8.1e-09 36.1 0.0 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase P5-ATPase PF12409.8 VDK77556.1 - 1.5e-17 63.9 9.0 1.5e-17 63.9 9.0 2.9 2 1 0 2 2 2 1 P5-type ATPase cation transporter Cation_ATPase_N PF00690.26 VDK77556.1 - 6.3e-10 38.6 0.0 1.4e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 VDK77556.1 - 9.4e-06 25.6 0.0 2.5e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 VDK77556.1 - 0.15 11.8 0.2 8.5 6.0 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase WD40 PF00400.32 VDK77572.1 - 1.9e-14 53.8 7.2 0.0022 18.8 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat RRM_1 PF00076.22 VDK77573.1 - 2.6e-08 33.6 0.0 3.7e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 7tm_1 PF00001.21 VDK77574.1 - 9.6e-35 120.2 4.1 1.1e-34 120.0 4.1 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 VDK77574.1 - 0.00036 20.0 6.7 0.00039 19.9 6.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srx PF10328.9 VDK77574.1 - 0.0023 17.6 10.0 0.0054 16.4 9.8 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx ATG11 PF10377.9 VDK77575.1 - 8.1e-10 38.9 0.4 2.9e-09 37.1 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein 11 TBK1_ULD PF18396.1 VDK77575.1 - 0.04 13.9 0.1 0.64 10.0 0.0 2.8 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain DUF1508 PF07411.12 VDK77575.1 - 0.064 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1508) DHHA1 PF02272.19 VDK77575.1 - 0.42 11.0 6.4 1.9 8.9 0.2 3.6 3 0 0 3 3 3 0 DHHA1 domain FadA PF09403.10 VDK77575.1 - 1.7 9.1 14.3 2.1 8.9 9.4 3.2 2 0 0 2 2 2 0 Adhesion protein FadA N_BRCA1_IG PF16158.5 VDK77577.1 - 1.8e-31 108.9 0.4 3.9e-31 107.8 0.4 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene UBA_4 PF14555.6 VDK77577.1 - 1.2e-10 41.0 0.4 2.3e-10 40.1 0.4 1.5 1 0 0 1 1 1 1 UBA-like domain CARDB PF07705.11 VDK77577.1 - 0.019 15.2 0.0 0.069 13.4 0.0 1.9 2 0 0 2 2 2 0 CARDB Aldo_ket_red PF00248.21 VDK77578.1 - 4e-49 167.4 0.2 2.9e-47 161.3 0.2 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DNA_pol_A_exo1 PF01612.20 VDK77579.1 - 6.3e-10 39.0 0.4 1.3e-09 38.0 0.4 1.5 1 0 0 1 1 1 1 3'-5' exonuclease DUF3456 PF11938.8 VDK77580.1 - 8.3e-13 49.1 5.8 5e-06 27.1 1.2 2.4 1 1 1 2 2 2 2 TLR4 regulator and MIR-interacting MSAP EGF_CA PF07645.15 VDK77580.1 - 8.9e-07 29.0 13.8 8.9e-07 29.0 13.8 5.8 3 1 1 4 4 4 1 Calcium-binding EGF domain Laminin_EGF PF00053.24 VDK77580.1 - 0.0025 17.9 7.6 0.0025 17.9 7.6 5.8 3 1 3 6 6 6 1 Laminin EGF domain cEGF PF12662.7 VDK77580.1 - 0.01 15.8 27.2 0.12 12.4 0.8 5.4 5 0 0 5 5 5 0 Complement Clr-like EGF-like Tme5_EGF_like PF09064.10 VDK77580.1 - 0.052 13.4 0.2 0.052 13.4 0.2 4.9 4 0 0 4 4 4 0 Thrombomodulin like fifth domain, EGF-like DUF443 PF04276.12 VDK77580.1 - 0.18 11.6 1.3 8.7 6.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF443) EGF_MSP1_1 PF12946.7 VDK77580.1 - 0.21 11.7 26.6 0.21 11.7 9.9 4.0 3 0 0 3 3 3 0 MSP1 EGF domain 1 PDZ_6 PF17820.1 VDK77581.1 - 1.7e-20 72.6 0.6 5.1e-10 39.1 0.1 2.3 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 VDK77581.1 - 1.5e-17 63.7 0.0 1.4e-07 31.8 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDK77581.1 - 7.9e-07 29.3 0.0 0.013 15.8 0.0 2.5 2 1 0 2 2 2 2 PDZ domain Thioredoxin_15 PF18403.1 VDK77581.1 - 0.093 12.6 0.2 11 5.9 0.0 2.3 2 0 0 2 2 2 0 Thioredoxin-like domain DSPc PF00782.20 VDK77598.1 - 6.2e-11 42.2 0.1 2.2e-10 40.5 0.1 2.0 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK77598.1 - 3.3e-08 33.4 0.0 6.3e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 VDK77598.1 - 0.0012 18.5 0.0 0.0025 17.5 0.0 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 VDK77598.1 - 0.12 12.4 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family PHO4 PF01384.20 VDK77599.1 - 6.8e-125 416.6 15.1 1e-124 416.0 15.1 1.2 1 0 0 1 1 1 1 Phosphate transporter family Fumarate_red_D PF02313.17 VDK77599.1 - 0.21 11.7 0.2 0.21 11.7 0.2 3.7 3 2 2 5 5 5 0 Fumarate reductase subunit D Zip PF02535.22 VDK77600.1 - 1.4e-38 133.0 11.4 1.2e-30 106.9 4.6 2.4 1 1 1 2 2 2 2 ZIP Zinc transporter PrgI PF12666.7 VDK77600.1 - 0.1 13.3 0.6 13 6.6 0.3 3.0 2 1 0 2 2 2 0 PrgI family protein CRCB PF02537.15 VDK77600.1 - 0.69 10.3 7.8 4.9 7.5 4.7 3.1 2 1 1 3 3 3 0 CrcB-like protein, Camphor Resistance (CrcB) Mob1_phocein PF03637.17 VDK77601.1 - 2.9e-71 238.9 0.1 3.7e-71 238.6 0.1 1.1 1 0 0 1 1 1 1 Mob1/phocein family RasGEF PF00617.19 VDK77602.1 - 3.4e-16 59.9 2.8 4.8e-16 59.5 0.5 2.5 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 VDK77602.1 - 0.0045 17.2 0.1 0.038 14.2 0.0 2.7 2 0 0 2 2 2 1 RasGEF N-terminal motif RasGEF PF00617.19 VDK77603.1 - 7.3e-22 78.4 0.1 6.9e-21 75.2 0.0 1.9 1 1 1 2 2 2 1 RasGEF domain MFS_2 PF13347.6 VDK77604.1 - 6.5e-20 71.1 28.6 9.8e-20 70.5 28.6 1.4 1 1 0 1 1 1 1 MFS/sugar transport protein KR PF08659.10 VDK77606.1 - 3.7e-46 157.3 0.2 1.2e-43 149.1 0.0 3.3 3 0 0 3 3 3 1 KR domain Thioesterase PF00975.20 VDK77606.1 - 9.9e-20 71.6 0.0 2.4e-19 70.4 0.0 1.7 1 1 0 1 1 1 1 Thioesterase domain ADH_zinc_N_2 PF13602.6 VDK77606.1 - 9.6e-18 65.5 0.1 3.8e-14 53.9 0.0 3.8 4 0 0 4 4 4 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 VDK77606.1 - 1.5e-17 63.8 0.0 3.3e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PP-binding PF00550.25 VDK77606.1 - 7.8e-09 35.8 0.2 2.3e-08 34.2 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short PF00106.25 VDK77606.1 - 2.4e-08 33.7 0.2 8.7e-05 22.1 0.0 3.1 3 0 0 3 3 3 2 short chain dehydrogenase Abhydrolase_1 PF00561.20 VDK77606.1 - 0.011 15.4 0.1 0.045 13.4 0.0 2.0 2 0 0 2 2 2 0 alpha/beta hydrolase fold Polysacc_synt_2 PF02719.15 VDK77606.1 - 0.034 13.3 0.0 0.67 9.0 0.0 2.4 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein FSH1 PF03959.13 VDK77606.1 - 0.049 13.3 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Epimerase PF01370.21 VDK77606.1 - 0.12 11.8 0.4 13 5.1 0.1 2.8 3 0 0 3 3 3 0 NAD dependent epimerase/dehydratase family AHD PF17793.1 VDK77606.1 - 0.14 12.0 0.0 0.44 10.4 0.0 1.8 1 0 0 1 1 1 0 ANC1 homology domain (AHD) YjeF_N PF03853.15 VDK77606.1 - 0.24 11.3 1.0 5.2 6.9 0.0 2.9 4 0 0 4 4 4 0 YjeF-related protein N-terminus Acyl_transf_1 PF00698.21 VDK77607.1 - 5.2e-73 246.3 0.0 7.3e-73 245.8 0.0 1.2 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 VDK77607.1 - 1.2e-65 221.6 1.3 5.1e-45 154.0 2.3 2.5 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 VDK77607.1 - 1.8e-40 137.6 0.0 3.3e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 VDK77607.1 - 1.3e-31 109.4 0.0 2.7e-31 108.3 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 VDK77607.1 - 3.8e-13 49.4 0.0 1.3e-12 47.6 0.0 1.7 1 1 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 VDK77607.1 - 0.001 18.5 0.0 0.0061 15.9 0.0 2.1 2 0 0 2 2 2 1 Thiolase, N-terminal domain Methyltransf_PK PF05891.12 VDK77607.1 - 0.0054 16.3 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.6 VDK77607.1 - 0.0073 16.2 0.0 0.015 15.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 VDK77607.1 - 0.036 13.3 0.1 0.085 12.1 0.1 1.5 1 0 0 1 1 1 0 O-methyltransferase domain ACP_syn_III PF08545.10 VDK77607.1 - 0.04 13.8 0.7 0.097 12.5 0.7 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Guanylate_cyc PF00211.20 VDK77617.1 - 4.3e-58 196.0 0.6 5.6e-58 195.6 0.6 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Kinase-PPPase PF03618.14 VDK77617.1 - 0.019 14.7 0.2 0.03 14.1 0.2 1.2 1 0 0 1 1 1 0 Kinase/pyrophosphorylase Costars PF14705.6 VDK77620.1 - 1.4e-25 89.2 0.0 2.4e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Costars TUDOR PF00567.24 VDK77622.1 - 7.4e-16 58.3 0.0 1.9e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Tudor domain Wzz PF02706.15 VDK77622.1 - 0.093 13.0 0.3 0.58 10.5 0.1 2.5 2 0 0 2 2 2 0 Chain length determinant protein MTS PF05175.14 VDK77624.1 - 1.6e-13 50.5 0.0 2.2e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 VDK77624.1 - 2.7e-12 46.7 0.0 3.5e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 VDK77624.1 - 6.5e-11 42.2 0.1 9.3e-11 41.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 VDK77624.1 - 4.6e-09 36.9 0.0 8e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 VDK77624.1 - 9.9e-07 28.6 0.0 1.4e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_11 PF08241.12 VDK77624.1 - 1.3e-05 25.8 0.0 2.3e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK77624.1 - 1.3e-05 25.0 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 VDK77624.1 - 9e-05 21.9 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain N6_Mtase PF02384.16 VDK77624.1 - 0.00024 20.5 0.0 0.00033 20.0 0.0 1.3 1 0 0 1 1 1 1 N-6 DNA Methylase Met_10 PF02475.16 VDK77624.1 - 0.001 18.9 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 VDK77624.1 - 0.0016 18.1 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 VDK77624.1 - 0.0025 17.8 0.0 0.0039 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK77624.1 - 0.0073 16.2 0.0 0.0093 15.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 VDK77624.1 - 0.016 14.8 0.1 0.024 14.2 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 VDK77624.1 - 0.021 14.3 0.0 0.081 12.4 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase PCMT PF01135.19 VDK77624.1 - 0.029 14.1 0.0 0.059 13.1 0.0 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 VDK77624.1 - 0.032 15.0 0.0 0.071 13.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 VDK77624.1 - 0.04 13.2 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase TRM PF02005.16 VDK77624.1 - 0.066 12.4 0.0 0.095 11.9 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase RhoGAP PF00620.27 VDK77625.1 - 3.7e-46 156.7 0.0 7.2e-45 152.5 0.0 2.7 3 0 0 3 3 3 1 RhoGAP domain PH PF00169.29 VDK77625.1 - 1.1e-11 45.1 0.2 2.3e-11 44.1 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 VDK77625.1 - 3.1e-11 43.7 0.1 6.2e-11 42.7 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain WW PF00397.26 VDK77625.1 - 2.6e-07 30.6 0.9 2.6e-07 30.6 0.9 2.5 3 0 0 3 3 3 1 WW domain DUF1708 PF08101.11 VDK77625.1 - 0.0014 17.8 0.0 0.003 16.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) Invas_SpaK PF03519.14 VDK77625.1 - 0.0032 17.5 0.3 0.0091 16.0 0.3 1.7 1 0 0 1 1 1 1 Invasion protein B family PH_11 PF15413.6 VDK77625.1 - 0.02 15.3 0.3 0.02 15.3 0.3 2.6 3 0 0 3 3 3 0 Pleckstrin homology domain RHH_4 PF13467.6 VDK77625.1 - 0.11 12.4 0.0 0.58 10.1 0.0 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix domain E1-E2_ATPase PF00122.20 VDK77626.1 - 1.2e-46 158.5 4.2 1.2e-46 158.5 4.2 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 VDK77626.1 - 4.5e-46 157.8 0.6 1.3e-45 156.3 0.2 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 VDK77626.1 - 4.7e-25 87.8 0.5 1.3e-13 51.2 0.5 2.6 2 0 0 2 2 2 2 Heavy-metal-associated domain Hydrolase_3 PF08282.12 VDK77626.1 - 0.0012 18.6 2.2 0.0017 18.2 0.8 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Endomucin PF07010.12 VDK77626.1 - 0.023 14.7 0.0 0.044 13.8 0.0 1.6 1 0 0 1 1 1 0 Endomucin HyaE PF07449.11 VDK77626.1 - 0.11 12.5 0.1 0.42 10.6 0.1 2.0 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TctB PF07331.11 VDK77626.1 - 10 6.4 17.7 8.6 6.6 0.4 3.8 4 0 0 4 4 4 0 Tripartite tricarboxylate transporter TctB family MRG PF05712.13 VDK77628.1 - 4.7e-43 146.8 0.1 7.4e-43 146.2 0.1 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 VDK77628.1 - 6.4e-08 32.4 1.1 1.9e-07 30.8 1.1 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Tudor_2 PF18104.1 VDK77628.1 - 0.0081 15.8 0.1 0.018 14.7 0.1 1.6 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain BAR PF03114.18 VDK77630.1 - 1.7e-36 126.1 7.5 2.6e-36 125.5 7.5 1.3 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 VDK77630.1 - 3.8e-12 45.9 0.0 6.7e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK77630.1 - 5.1e-08 32.5 0.0 9.8e-08 31.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK77630.1 - 1.8e-07 30.6 0.0 3.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain BAR_3 PF16746.5 VDK77630.1 - 3.5e-06 26.9 0.7 5.5e-06 26.3 0.7 1.2 1 0 0 1 1 1 1 BAR domain of APPL family COG5 PF10392.9 VDK77630.1 - 0.0035 17.5 0.7 0.051 13.8 0.1 2.6 3 0 0 3 3 3 1 Golgi transport complex subunit 5 DUF4736 PF15883.5 VDK77630.1 - 0.049 13.4 0.7 2.4 7.8 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) GCP_C_terminal PF04130.13 VDK77630.1 - 0.092 12.2 5.4 0.25 10.8 5.4 1.6 1 1 0 1 1 1 0 Gamma tubulin complex component C-terminal Interferon PF00143.19 VDK77630.1 - 0.17 12.0 1.0 4 7.6 0.0 2.5 2 1 0 2 2 2 0 Interferon alpha/beta domain GAS PF13851.6 VDK77630.1 - 1.4 8.2 6.0 2.1 7.7 4.3 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Macoilin PF09726.9 VDK77630.1 - 1.9 6.9 13.0 0.075 11.6 1.0 2.1 2 0 0 2 2 2 0 Macoilin family TIMELESS PF04821.14 VDK77639.1 - 2.4e-40 138.6 0.3 5.5e-40 137.4 0.3 1.6 1 0 0 1 1 1 1 Timeless protein TIMELESS_C PF05029.13 VDK77639.1 - 1.4e-24 87.2 0.5 1.4e-24 87.2 0.5 2.9 2 1 1 3 3 3 1 Timeless protein C terminal region CSD PF00313.22 VDK77640.1 - 3.7e-28 97.2 0.3 6.7e-28 96.3 0.3 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain CPG4 PF15481.6 VDK77641.1 - 0.0019 18.8 0.7 0.6 10.8 0.1 2.3 1 1 1 2 2 2 2 Chondroitin proteoglycan 4 dUTPase PF00692.19 VDK77642.1 - 7.1e-42 142.1 0.0 9.2e-42 141.8 0.0 1.1 1 0 0 1 1 1 1 dUTPase DUF5557 PF17712.1 VDK77642.1 - 0.13 12.2 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5557) E2F_TDP PF02319.20 VDK77644.1 - 1.2e-24 86.1 0.7 3.9e-14 52.5 0.1 2.8 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 VDK77644.1 - 0.015 15.2 0.0 0.044 13.7 0.0 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB PseudoU_synth_1 PF01416.20 VDK77645.1 - 4.1e-29 101.2 0.0 2.8e-27 95.3 0.0 2.6 2 1 0 2 2 2 1 tRNA pseudouridine synthase YIEGIA PF14045.6 VDK77645.1 - 0.18 10.6 0.0 0.29 9.9 0.0 1.3 1 0 0 1 1 1 0 YIEGIA protein MRP_L53 PF10780.9 VDK77649.1 - 7.5e-06 26.0 0.0 1e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 L51_S25_CI-B8 PF05047.16 VDK77649.1 - 0.0013 18.7 0.1 0.0021 18.0 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain C2 PF00168.30 VDK77661.1 - 1.1e-34 118.8 0.0 4.2e-16 59.1 0.0 2.6 2 0 0 2 2 2 2 C2 domain PDZ_6 PF17820.1 VDK77661.1 - 2.8e-10 39.9 0.2 7e-10 38.6 0.2 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDK77661.1 - 2.6e-07 30.9 0.0 5e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK77661.1 - 0.013 15.8 0.1 0.029 14.7 0.1 1.5 1 0 0 1 1 1 0 PDZ domain Sas10_Utp3 PF04000.15 VDK77663.1 - 1.3e-05 25.7 1.3 1.9e-05 25.2 0.1 1.8 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Sec16_C PF12931.7 VDK77665.1 - 2.9e-18 66.6 1.4 1.5e-17 64.2 0.1 2.5 2 1 0 2 2 2 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 VDK77665.1 - 6e-06 26.8 0.0 3.5e-05 24.4 0.0 2.5 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region RRM_1 PF00076.22 VDK77666.1 - 2.4e-27 94.5 0.0 2.1e-14 53.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK77666.1 - 0.00015 21.3 0.0 0.56 9.8 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK77666.1 - 0.0047 16.8 0.0 0.72 9.8 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif Trnau1ap PF17654.1 VDK77666.1 - 2 9.3 10.0 6.8 7.6 9.7 2.0 1 1 0 1 1 1 0 Selenocysteine tRNA 1 associated proteins ketoacyl-synt PF00109.26 VDK77668.1 - 3.5e-157 521.5 3.5 4.1e-57 193.6 0.4 3.4 3 0 0 3 3 3 3 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 VDK77668.1 - 5.8e-87 290.2 0.1 4e-43 147.4 0.0 3.9 3 0 0 3 3 3 3 KR domain Ketoacyl-synt_C PF02801.22 VDK77668.1 - 4.8e-83 275.0 9.5 2.3e-28 98.6 0.2 3.7 3 0 0 3 3 3 3 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 VDK77668.1 - 1.4e-57 192.0 2.3 6.1e-11 42.5 0.0 5.7 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding PF00501.28 VDK77668.1 - 1e-51 175.9 0.0 2.1e-51 174.9 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme Acyl_transf_1 PF00698.21 VDK77668.1 - 6.2e-45 154.1 0.0 5.1e-21 75.5 0.0 2.9 3 0 0 3 3 3 2 Acyl transferase domain Condensation PF00668.20 VDK77668.1 - 2.4e-41 141.9 0.5 6.6e-41 140.4 0.5 1.8 1 0 0 1 1 1 1 Condensation domain KAsynt_C_assoc PF16197.5 VDK77668.1 - 1.6e-35 121.9 2.5 2.8e-12 47.1 0.3 3.9 3 0 0 3 3 3 3 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 VDK77668.1 - 1.6e-29 103.1 0.0 9.4e-15 54.6 0.0 3.4 3 0 0 3 3 3 3 Polyketide synthase dehydratase adh_short PF00106.25 VDK77668.1 - 4.3e-19 68.7 2.6 9e-06 25.3 0.0 3.7 3 0 0 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 VDK77668.1 - 2.5e-13 50.2 2.7 0.00022 20.9 0.0 3.7 3 0 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase Thioesterase PF00975.20 VDK77668.1 - 2.9e-12 47.2 0.0 1e-11 45.5 0.0 1.9 1 0 0 1 1 1 1 Thioesterase domain Thiolase_N PF00108.23 VDK77668.1 - 2.3e-06 27.2 2.3 0.029 13.7 0.1 3.6 4 0 0 4 4 4 2 Thiolase, N-terminal domain Sacchrp_dh_NADP PF03435.18 VDK77668.1 - 0.00011 22.4 0.0 0.0024 18.1 0.0 3.1 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain Abhydrolase_5 PF12695.7 VDK77668.1 - 0.00018 21.3 0.5 0.0013 18.5 0.0 2.8 3 0 0 3 3 2 1 Alpha/beta hydrolase family AMP-binding_C PF13193.6 VDK77668.1 - 0.0023 18.9 0.0 0.0064 17.4 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PGAP1 PF07819.13 VDK77668.1 - 0.0029 17.3 0.1 0.027 14.2 0.0 2.6 2 0 0 2 2 2 1 PGAP1-like protein ACP_syn_III PF08545.10 VDK77668.1 - 0.0063 16.3 8.9 0.098 12.5 0.4 3.9 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Abhydrolase_1 PF00561.20 VDK77668.1 - 0.0071 16.0 0.0 0.073 12.7 0.0 2.6 3 0 0 3 3 3 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 VDK77668.1 - 0.011 15.3 0.1 0.21 11.1 0.1 2.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 VDK77668.1 - 0.019 14.3 0.1 0.07 12.4 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 VDK77668.1 - 0.026 14.4 0.0 0.083 12.7 0.0 1.8 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 VDK77668.1 - 0.056 14.1 0.0 0.37 11.4 0.0 2.3 3 0 0 3 3 2 0 Alpha/beta hydrolase family SpoVAD PF07451.11 VDK77668.1 - 0.07 11.8 2.7 0.052 12.2 0.1 2.1 2 0 0 2 2 2 0 Stage V sporulation protein AD (SpoVAD) COesterase PF00135.28 VDK77669.1 - 7.4e-87 292.3 0.0 3e-86 290.3 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 VDK77669.1 - 0.00026 20.9 0.0 0.00071 19.5 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Synaptobrevin PF00957.21 VDK77669.1 - 0.92 9.3 3.4 1.9 8.3 3.4 1.5 1 0 0 1 1 1 0 Synaptobrevin Ly49 PF08391.10 VDK77669.1 - 1.2 9.5 3.8 0.78 10.1 1.6 1.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region CDK2AP PF09806.9 VDK77676.1 - 0.0047 17.0 0.3 0.005 16.9 0.3 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein Glyco_hydro_18 PF00704.28 VDK77677.1 - 1.4e-10 41.4 0.0 1.8e-10 41.0 0.0 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Gelsolin PF00626.22 VDK77680.1 - 4.3e-57 189.9 0.2 2.1e-14 53.1 0.0 4.2 4 0 0 4 4 4 4 Gelsolin repeat PSII_BNR PF14870.6 VDK77680.1 - 0.3 10.3 3.9 0.79 8.9 0.4 3.0 3 1 1 4 4 4 0 Photosynthesis system II assembly factor YCF48 AMP-binding PF00501.28 VDK77683.1 - 1.2e-62 212.0 0.0 1.2e-61 208.6 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 VDK77683.1 - 5.2e-09 37.0 0.0 8.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain UCH PF00443.29 VDK77684.1 - 1.2e-45 156.0 0.1 1.6e-45 155.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK77684.1 - 5.1e-10 39.5 1.1 1e-07 31.9 1.1 3.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GoLoco PF02188.17 VDK77687.1 - 3.8e-23 80.6 21.6 2.5e-10 39.6 1.2 4.2 4 0 0 4 4 4 3 GoLoco motif TPR_12 PF13424.6 VDK77687.1 - 1.4e-21 76.5 24.3 5.1e-11 42.7 4.0 4.9 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 VDK77687.1 - 5.3e-17 60.8 24.1 0.00019 21.1 0.5 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 VDK77687.1 - 1.5e-10 40.4 18.9 0.0069 16.3 0.5 7.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 VDK77687.1 - 4.2e-06 26.5 32.6 0.044 13.9 0.9 7.8 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDK77687.1 - 3e-05 23.9 22.0 0.0016 18.5 0.5 6.5 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 VDK77687.1 - 0.00057 19.7 19.0 0.086 12.7 1.0 5.6 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 VDK77687.1 - 0.065 13.9 1.6 50 4.8 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK77687.1 - 0.074 13.5 5.9 7.4 7.2 0.2 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK77687.1 - 0.91 8.8 6.3 14 4.9 0.2 3.1 2 1 0 3 3 3 0 MalT-like TPR region Xpo1 PF08389.12 VDK77688.1 - 1.2e-16 61.1 0.7 2.1e-16 60.3 0.7 1.4 1 0 0 1 1 1 1 Exportin 1-like protein Thiolase_N PF00108.23 VDK77699.1 - 1.8e-19 70.1 0.7 1.9e-18 66.8 0.7 2.1 1 1 0 1 1 1 1 Thiolase, N-terminal domain SCP2 PF02036.17 VDK77699.1 - 2e-17 63.5 0.2 5.7e-17 62.1 0.2 1.8 1 0 0 1 1 1 1 SCP-2 sterol transfer family Thiolase_C PF02803.18 VDK77699.1 - 3.7e-12 46.0 1.1 2.4e-11 43.4 0.1 2.8 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 VDK77699.1 - 0.003 17.2 1.0 0.0046 16.6 0.3 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 VDK77699.1 - 0.005 16.8 0.1 1.5 8.9 0.0 2.9 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.11 VDK77699.1 - 0.026 13.2 0.1 0.048 12.4 0.1 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Alkyl_sulf_C PF14864.6 VDK77699.1 - 0.035 14.4 0.0 0.092 13.0 0.0 1.7 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal NKAIN PF05640.14 VDK77700.1 - 6.6e-18 64.7 7.8 1.1e-17 64.0 7.8 1.3 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein Sarcoglycan_1 PF04790.13 VDK77700.1 - 0.23 10.7 2.2 0.41 10.0 2.2 1.3 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein T-box PF00907.22 VDK77701.1 - 8.3e-08 32.7 0.1 1.2e-07 32.2 0.1 1.2 1 0 0 1 1 1 1 T-box T-box PF00907.22 VDK77702.1 - 7.3e-61 205.6 0.4 7.3e-61 205.6 0.4 1.4 2 0 0 2 2 2 1 T-box LRR_4 PF12799.7 VDK77705.1 - 4e-06 27.1 8.9 0.73 10.3 0.1 5.2 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) GCS PF03074.16 VDK77707.1 - 5.1e-167 555.8 0.0 6.2e-167 555.5 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase Chorion_3 PF05387.11 VDK77709.1 - 0.022 14.4 5.0 0.025 14.2 5.0 1.0 1 0 0 1 1 1 0 Chorion family 3 zf-C2H2_8 PF15909.5 VDK77711.1 - 0.0055 17.0 8.4 0.054 13.8 8.1 2.5 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 VDK77711.1 - 1.8 9.6 16.9 1.7 9.7 0.9 4.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK77711.1 - 3.6 8.2 15.1 1.2 9.7 0.3 3.5 3 0 0 3 3 3 0 Zinc finger, C2H2 type Ig_3 PF13927.6 VDK77723.1 - 4.1e-43 145.8 0.1 2.2e-09 37.8 0.0 6.1 5 0 0 5 5 5 4 Immunoglobulin domain I-set PF07679.16 VDK77723.1 - 4e-39 132.6 0.0 1.4e-08 34.6 0.0 5.7 6 0 0 6 6 6 4 Immunoglobulin I-set domain Ig_2 PF13895.6 VDK77723.1 - 1.3e-30 105.5 0.0 2.5e-07 30.9 0.0 5.5 5 0 0 5 5 5 4 Immunoglobulin domain fn3 PF00041.21 VDK77723.1 - 2.3e-28 98.4 6.5 5.8e-07 29.8 0.3 6.4 6 0 0 6 6 6 5 Fibronectin type III domain ig PF00047.25 VDK77723.1 - 7.4e-26 90.1 0.3 7.3e-06 26.1 0.0 6.0 6 0 0 6 6 6 4 Immunoglobulin domain Bravo_FIGEY PF13882.6 VDK77723.1 - 2.5e-19 70.4 1.4 2.5e-19 70.4 1.4 2.4 2 0 0 2 2 2 1 Bravo-like intracellular region V-set PF07686.17 VDK77723.1 - 1e-06 28.9 7.9 0.47 10.6 0.0 8.1 8 2 1 9 9 9 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK77723.1 - 0.0018 18.3 0.0 0.033 14.2 0.0 3.0 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Pur_ac_phosph_N PF16656.5 VDK77723.1 - 0.015 15.8 1.1 3.3 8.4 0.0 4.5 5 0 0 5 5 5 0 Purple acid Phosphatase, N-terminal domain DUF2207 PF09972.9 VDK77723.1 - 0.026 13.3 2.5 0.042 12.6 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) WBP-1 PF11669.8 VDK77723.1 - 0.041 14.5 0.0 0.096 13.3 0.0 1.6 1 0 0 1 1 1 0 WW domain-binding protein 1 Herpes_gE PF02480.16 VDK77723.1 - 0.059 12.1 1.1 0.073 11.8 0.0 1.6 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E Hum_adeno_E3A PF05393.11 VDK77723.1 - 0.12 12.4 0.3 0.32 11.0 0.3 1.7 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein EphA2_TM PF14575.6 VDK77723.1 - 1.3 9.9 0.0 1.3 9.9 0.0 3.2 2 1 1 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain VWA PF00092.28 VDK77724.1 - 2.5e-51 174.4 0.1 4e-25 89.1 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 VDK77724.1 - 3.6e-25 88.7 0.0 2e-11 44.5 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 VDK77724.1 - 1.9e-05 24.2 0.1 0.098 12.0 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 VDK77724.1 - 0.00035 20.7 0.0 0.012 15.7 0.0 2.6 3 0 0 3 3 3 1 vWA found in TerF C terminus Tir_receptor_C PF07489.11 VDK77724.1 - 0.13 12.2 9.4 0.23 11.4 9.4 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus SSP160 PF06933.11 VDK77724.1 - 0.17 10.0 10.7 0.22 9.7 10.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 VDK77724.1 - 2.2 6.2 7.2 3.1 5.7 7.2 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 VDK77724.1 - 2.3 8.2 15.6 4.6 7.2 15.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) zf-CSL PF05207.13 VDK77725.1 - 2e-20 72.3 2.6 2.5e-20 71.9 2.6 1.1 1 0 0 1 1 1 1 CSL zinc finger Pkinase PF00069.25 VDK77726.1 - 5.4e-55 186.6 0.0 6.6e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77726.1 - 5.9e-40 137.2 0.0 7.3e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK77726.1 - 4.2e-06 26.3 0.0 1.3e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDK77726.1 - 0.00037 19.4 0.0 0.0012 17.7 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 VDK77726.1 - 0.0015 17.6 0.1 0.0032 16.6 0.1 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 VDK77726.1 - 0.0034 16.4 0.0 0.0054 15.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 VDK77726.1 - 0.18 11.7 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family CD34_antigen PF06365.12 VDK77728.1 - 0.0006 19.5 0.7 0.001 18.7 0.5 1.5 1 1 0 1 1 1 1 CD34/Podocalyxin family EphA2_TM PF14575.6 VDK77728.1 - 0.0018 19.1 3.0 0.0094 16.8 0.2 2.4 1 1 1 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Laminin_EGF PF00053.24 VDK77728.1 - 0.0036 17.4 2.9 0.0067 16.6 2.9 1.5 1 0 0 1 1 1 1 Laminin EGF domain Sid-5 PF17204.3 VDK77728.1 - 0.012 15.7 0.1 0.022 14.9 0.1 1.4 1 0 0 1 1 1 0 Sid-5 family Oxidored_q3 PF00499.20 VDK77728.1 - 0.013 15.2 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 BatD PF13584.6 VDK77728.1 - 0.037 12.8 0.0 0.045 12.6 0.0 1.3 1 0 0 1 1 1 0 Oxygen tolerance CSG2 PF16965.5 VDK77728.1 - 0.039 12.9 0.2 0.042 12.8 0.2 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4051 PF13260.6 VDK77728.1 - 0.039 13.7 0.5 0.081 12.7 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) DUF4320 PF14208.6 VDK77728.1 - 0.051 13.7 1.3 0.091 12.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) DUF1366 PF07104.11 VDK77730.1 - 0.005 16.5 1.0 0.0055 16.4 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1366) Perilipin PF03036.16 VDK77730.1 - 0.025 13.6 1.0 0.03 13.3 1.0 1.0 1 0 0 1 1 1 0 Perilipin family Baculo_F PF12259.8 VDK77730.1 - 0.033 12.7 1.1 0.039 12.5 1.1 1.0 1 0 0 1 1 1 0 Baculovirus F protein AMOP PF03782.17 VDK77731.1 - 1.1e-32 113.2 9.9 3.4e-32 111.5 9.9 1.9 1 1 0 1 1 1 1 AMOP domain DUF3328 PF11807.8 VDK77731.1 - 0.042 13.6 0.3 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) NIDO PF06119.14 VDK77732.1 - 1.2e-06 29.4 0.0 1.4e-05 25.9 0.0 2.8 3 0 0 3 3 3 1 Nidogen-like F-actin_cap_A PF01267.17 VDK77748.1 - 6.6e-84 281.5 5.5 8.2e-84 281.2 5.5 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit S1FA PF04689.13 VDK77749.1 - 0.065 13.4 0.1 0.2 11.8 0.0 1.7 2 0 0 2 2 2 0 DNA binding protein S1FA 7TM_GPCR_Srx PF10328.9 VDK77749.1 - 0.12 12.0 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DENN PF02141.21 VDK77750.1 - 2e-45 155.1 2.4 1e-43 149.4 0.3 2.6 3 0 0 3 3 3 2 DENN (AEX-3) domain uDENN PF03456.18 VDK77750.1 - 1.8e-14 54.2 0.6 5.5e-14 52.7 0.6 1.9 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 VDK77750.1 - 1.5e-12 47.3 9.8 3.2e-12 46.2 9.8 1.6 1 0 0 1 1 1 1 dDENN domain PPR_2 PF13041.6 VDK77750.1 - 0.00098 19.3 0.0 0.0075 16.4 0.0 2.4 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 VDK77750.1 - 0.076 13.3 0.0 0.48 10.8 0.0 2.4 2 0 0 2 2 2 0 PPR repeat fn3 PF00041.21 VDK77751.1 - 0 1465.8 53.4 1.8e-16 60.3 0.0 31.9 31 0 0 31 31 31 31 Fibronectin type III domain I-set PF07679.16 VDK77751.1 - 0 1303.2 49.7 3.2e-24 84.8 0.0 37.6 42 0 0 42 42 38 28 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK77751.1 - 1.5e-246 797.8 35.1 2.3e-15 57.0 0.1 31.7 32 0 0 32 32 30 27 Immunoglobulin domain Ig_2 PF13895.6 VDK77751.1 - 5.9e-139 452.7 24.5 1e-07 32.2 0.2 28.9 29 0 0 29 29 28 23 Immunoglobulin domain ig PF00047.25 VDK77751.1 - 3.5e-121 395.6 39.0 8.6e-11 41.9 0.0 26.6 26 0 0 26 26 26 19 Immunoglobulin domain Pkinase PF00069.25 VDK77751.1 - 2.7e-68 230.2 0.0 5.2e-68 229.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pur_ac_phosph_N PF16656.5 VDK77751.1 - 4.6e-51 171.3 24.1 0.53 10.9 0.0 29.2 29 1 0 29 29 29 7 Purple acid Phosphatase, N-terminal domain V-set PF07686.17 VDK77751.1 - 1.1e-45 154.3 38.1 0.057 13.6 0.1 29.7 28 7 0 28 28 27 8 Immunoglobulin V-set domain Pkinase_Tyr PF07714.17 VDK77751.1 - 5e-34 117.8 0.0 8.2e-34 117.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Tissue_fac PF01108.17 VDK77751.1 - 1.7e-30 105.0 0.0 0.082 12.8 0.0 20.1 23 0 0 23 23 19 3 Tissue factor fn3_4 PF16794.5 VDK77751.1 - 7.4e-25 86.9 0.0 0.31 11.0 0.0 18.2 19 1 0 19 19 16 3 Fibronectin-III type domain Y_Y_Y PF07495.13 VDK77751.1 - 1.3e-24 85.9 27.5 0.78 9.7 0.1 21.6 25 0 0 25 25 20 4 Y_Y_Y domain C2-set_2 PF08205.12 VDK77751.1 - 7.5e-23 80.4 24.4 0.51 10.4 0.0 18.1 21 0 0 21 21 19 6 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 VDK77751.1 - 1.9e-18 66.6 21.3 0.055 13.7 0.0 20.2 24 0 0 24 24 21 2 Natural killer cell receptor 2B4 fn3_2 PF16893.5 VDK77751.1 - 1.3e-14 54.1 0.0 0.84 9.8 0.0 13.1 15 0 0 15 15 14 2 Fibronectin type III domain DUF2369 PF10179.9 VDK77751.1 - 1.5e-12 47.8 0.0 3.5 8.1 0.0 14.6 20 0 0 20 20 14 1 Uncharacterised conserved protein (DUF2369) Izumo-Ig PF16706.5 VDK77751.1 - 3.2e-11 43.1 10.8 0.3 11.2 0.0 12.9 15 0 0 15 15 12 1 Izumo-like Immunoglobulin domain BiPBP_C PF06832.12 VDK77751.1 - 7.6e-09 35.5 0.0 1.5 8.9 0.0 11.5 14 1 0 14 14 10 1 Penicillin-Binding Protein C-terminus Family Ig_5 PF16681.5 VDK77751.1 - 2.7e-08 34.1 21.6 1 9.8 0.1 13.2 15 0 0 15 15 13 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 VDK77751.1 - 1.6e-06 28.1 0.9 0.31 11.1 0.0 6.3 6 0 0 6 6 4 1 C17orf99 Ig domain Ig_6 PF18452.1 VDK77751.1 - 8.1e-06 25.3 0.1 10 5.8 0.0 8.7 13 0 0 13 13 9 0 Immunoglobulin domain DUF11 PF01345.18 VDK77751.1 - 3.5e-05 24.0 9.6 17 5.8 0.0 11.6 13 0 0 13 13 11 0 Domain of unknown function DUF11 ChitinaseA_N PF08329.10 VDK77751.1 - 4.1e-05 23.2 12.6 24 4.6 0.0 11.6 16 0 0 16 16 12 0 Chitinase A, N-terminal domain PA14 PF07691.12 VDK77751.1 - 5.1e-05 23.1 0.5 40 4.0 0.0 9.7 13 0 0 13 13 9 0 PA14 domain zf-UBP_var PF17807.1 VDK77751.1 - 0.00031 20.4 0.0 3.5 7.5 0.0 4.3 4 0 0 4 4 4 1 Variant UBP zinc finger C1-set PF07654.15 VDK77751.1 - 0.0007 19.9 18.8 6.7 7.2 0.1 12.5 16 0 0 16 16 11 0 Immunoglobulin C1-set domain Kinase-like PF14531.6 VDK77751.1 - 0.0036 16.7 0.0 0.0069 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK77751.1 - 0.011 15.1 0.1 0.023 14.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Interfer-bind PF09294.10 VDK77751.1 - 0.026 14.8 17.4 39 4.6 0.0 12.0 15 0 0 15 15 12 0 Interferon-alpha/beta receptor, fibronectin type III TusA PF01206.17 VDK77751.1 - 0.12 12.2 0.1 12 5.9 0.0 4.0 4 0 0 4 4 3 0 Sulfurtransferase TusA Choline_kinase PF01633.20 VDK77751.1 - 0.13 11.8 0.2 0.3 10.7 0.2 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ig_4 PF16680.5 VDK77751.1 - 0.2 11.9 38.5 6.3 7.1 0.2 11.7 14 0 0 14 14 9 0 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 VDK77751.1 - 1.3 9.0 12.6 4.3 7.3 0.0 6.6 7 0 0 7 7 6 0 CD47 immunoglobulin-like domain Arf PF00025.21 VDK77753.1 - 8.1e-41 139.4 0.1 9.2e-41 139.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK77753.1 - 1.1e-17 64.3 0.0 1.4e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK77753.1 - 1.6e-17 63.6 0.0 1.8e-17 63.4 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 VDK77753.1 - 1.6e-10 40.7 0.2 6.8e-07 28.8 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 VDK77753.1 - 1.1e-09 38.0 0.0 1.2e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK77753.1 - 3.6e-09 36.7 0.0 5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 VDK77753.1 - 7.6e-09 35.3 0.0 8.8e-09 35.0 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 VDK77753.1 - 0.00024 21.2 0.1 0.32 11.1 0.1 2.1 1 1 1 2 2 2 2 Dynamin family VirE PF05272.11 VDK77753.1 - 0.0056 16.4 0.0 0.0073 16.1 0.0 1.2 1 0 0 1 1 1 1 Virulence-associated protein E FeoB_N PF02421.18 VDK77753.1 - 0.0078 15.7 0.3 0.17 11.4 0.1 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 VDK77753.1 - 0.014 14.9 0.0 0.11 12.1 0.0 1.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA PF00004.29 VDK77753.1 - 0.015 15.7 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 VDK77753.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_15 PF13175.6 VDK77753.1 - 0.21 11.3 0.0 0.21 11.3 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain zf-BED PF02892.15 VDK77755.1 - 9.3e-13 48.0 1.5 2.1e-12 46.9 1.5 1.6 1 0 0 1 1 1 1 BED zinc finger H-kinase_dim PF02895.14 VDK77755.1 - 0.11 12.9 0.0 0.47 10.9 0.0 2.1 2 0 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain SNF2_N PF00176.23 VDK77763.1 - 1e-51 175.8 0.5 2e-51 174.8 0.5 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK77763.1 - 1.8e-16 60.5 0.0 7.1e-16 58.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF3535 PF12054.8 VDK77763.1 - 9.8e-14 51.4 0.1 2e-12 47.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) HEAT_EZ PF13513.6 VDK77763.1 - 2.8e-10 40.5 8.8 0.19 12.3 0.0 8.1 9 0 0 9 9 9 3 HEAT-like repeat HEAT PF02985.22 VDK77763.1 - 1.2e-09 37.6 19.6 0.21 11.9 0.1 8.7 10 0 0 10 10 10 4 HEAT repeat ResIII PF04851.15 VDK77763.1 - 2.3e-07 30.9 0.0 4.4e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HEAT_2 PF13646.6 VDK77763.1 - 1.1e-06 28.9 4.9 0.00029 21.2 0.1 4.3 6 0 0 6 6 6 2 HEAT repeats HEAT_PBS PF03130.16 VDK77763.1 - 0.028 15.1 0.1 3.1 8.7 0.0 3.8 2 1 0 2 2 2 0 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.7 VDK77763.1 - 0.31 11.7 1.1 40 4.9 0.0 4.3 4 1 1 5 5 5 0 Vacuolar 14 Fab1-binding region Evr1_Alr PF04777.13 VDK77764.1 - 3.7e-19 69.0 0.3 1.3e-18 67.3 0.3 2.0 1 0 0 1 1 1 1 Erv1 / Alr family Thioredoxin PF00085.20 VDK77764.1 - 4.6e-18 65.1 0.0 7e-16 58.1 0.0 2.8 2 0 0 2 2 2 1 Thioredoxin QSOX_Trx1 PF18108.1 VDK77764.1 - 1.1e-05 25.6 0.0 2.3e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 QSOX Trx-like domain Thioredoxin_8 PF13905.6 VDK77764.1 - 0.0013 19.0 0.2 0.017 15.5 0.0 2.6 2 1 1 3 3 3 1 Thioredoxin-like FAD_SOX PF18371.1 VDK77764.1 - 0.0034 17.7 0.0 0.045 14.1 0.0 2.3 1 1 1 2 2 2 1 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase IR1-M PF12185.8 VDK77764.1 - 0.085 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain RasGEF PF00617.19 VDK77765.1 - 4.7e-53 180.0 0.1 1e-52 178.9 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain PDZ PF00595.24 VDK77765.1 - 5.2e-12 45.9 0.2 1.5e-11 44.5 0.2 1.8 1 0 0 1 1 1 1 PDZ domain RasGEF_N PF00618.20 VDK77765.1 - 1.6e-10 41.1 0.6 3.4e-09 36.9 0.6 2.7 1 1 0 1 1 1 1 RasGEF N-terminal motif PDZ_6 PF17820.1 VDK77765.1 - 1.2e-08 34.7 0.0 2.8e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 PDZ domain RA PF00788.23 VDK77765.1 - 1.8e-08 34.9 0.1 4.6e-08 33.6 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain cNMP_binding PF00027.29 VDK77765.1 - 5.4e-08 32.8 0.0 0.0052 16.8 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain PDZ_2 PF13180.6 VDK77765.1 - 6.6e-05 23.2 0.0 0.0002 21.6 0.0 1.8 1 0 0 1 1 1 1 PDZ domain Cupin_2 PF07883.11 VDK77765.1 - 0.057 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Cupin domain Cupin_3 PF05899.12 VDK77765.1 - 0.1 12.3 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF861) WGG PF10273.9 VDK77766.1 - 1.4e-16 60.9 0.6 5.3e-16 59.1 0.3 2.0 1 1 1 2 2 2 1 Pre-rRNA-processing protein TSR2 RRP7 PF12923.7 VDK77766.1 - 0.0026 17.9 0.4 0.0039 17.3 0.4 1.4 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain PAD PF03068.15 VDK77766.1 - 0.096 11.7 0.0 0.17 10.9 0.0 1.4 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) WD40 PF00400.32 VDK77768.1 - 6.4e-47 156.6 23.7 2.1e-07 31.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK77768.1 - 2.2e-08 34.3 2.0 0.12 12.7 0.0 4.6 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK77768.1 - 0.0026 16.8 0.1 7 5.5 0.0 3.3 3 0 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 VDK77768.1 - 0.0038 15.9 10.8 0.17 10.5 0.1 4.6 3 2 3 6 6 6 2 Nucleoporin Nup120/160 PD40 PF07676.12 VDK77768.1 - 0.0069 16.3 0.1 6.4 6.8 0.0 4.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 VDK77768.1 - 0.062 12.6 0.0 8.4 5.6 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain DUF1416 PF07210.12 VDK77768.1 - 0.081 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1416) STAT_bind PF02864.15 VDK77771.1 - 1.2e-33 116.5 0.1 2.6e-33 115.4 0.1 1.6 1 0 0 1 1 1 1 STAT protein, DNA binding domain STAT_alpha PF01017.20 VDK77771.1 - 6.5e-19 68.5 9.9 9.9e-19 67.9 9.9 1.3 1 0 0 1 1 1 1 STAT protein, all-alpha domain SH2 PF00017.24 VDK77771.1 - 9.3e-06 25.7 0.0 2.6e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 SH2 domain Tup_N PF08581.10 VDK77771.1 - 0.0018 18.5 1.9 0.02 15.2 0.3 2.7 2 1 0 2 2 2 1 Tup N-terminal EF-hand_12 PF17901.1 VDK77771.1 - 0.018 15.5 2.5 0.11 12.9 2.5 2.4 1 1 0 1 1 1 0 EF-hand fold domain CENP-F_leu_zip PF10473.9 VDK77771.1 - 1.5 8.8 7.1 0.72 9.9 3.2 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CPG4 PF15481.6 VDK77775.1 - 1e-12 48.5 6.1 1e-12 48.5 6.1 2.2 2 0 0 2 2 2 1 Chondroitin proteoglycan 4 DUF4179 PF13786.6 VDK77775.1 - 0.14 12.7 0.0 0.34 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) zf-RING_2 PF13639.6 VDK77776.1 - 1.8e-10 40.9 8.0 7.9e-10 38.9 8.0 2.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK77776.1 - 5.5e-08 32.7 4.3 1.6e-07 31.2 4.3 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 VDK77776.1 - 2.6e-07 30.4 7.4 6.6e-07 29.1 7.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK77776.1 - 1.5e-06 28.0 8.1 4.4e-06 26.6 8.1 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 VDK77776.1 - 5.3e-06 26.2 6.5 1.5e-05 24.7 6.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK77776.1 - 8.2e-05 22.8 7.9 0.00032 20.9 7.9 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 VDK77776.1 - 0.00033 20.7 1.5 0.00091 19.2 1.5 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 VDK77776.1 - 0.00044 19.8 6.3 0.0012 18.5 6.3 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 VDK77776.1 - 0.00055 19.6 5.3 0.0016 18.1 5.3 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 VDK77776.1 - 0.00065 19.8 5.0 0.0025 17.9 5.0 2.2 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING FYVE PF01363.21 VDK77776.1 - 0.0012 18.9 9.7 0.0072 16.4 3.7 2.7 1 1 1 2 2 2 1 FYVE zinc finger zf-RING_4 PF14570.6 VDK77776.1 - 0.002 17.8 5.7 0.0065 16.2 5.7 1.9 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-Nse PF11789.8 VDK77776.1 - 0.0028 17.4 3.7 0.0028 17.4 3.7 2.0 2 0 0 2 2 1 1 Zinc-finger of the MIZ type in Nse subunit YabA PF06156.13 VDK77776.1 - 0.0036 17.9 9.0 0.068 13.8 3.5 2.7 1 1 1 2 2 2 1 Initiation control protein YabA zf-UDP PF14569.6 VDK77776.1 - 0.009 16.1 2.7 0.009 16.1 2.7 1.9 2 0 0 2 2 1 1 Zinc-binding RING-finger FYVE_2 PF02318.16 VDK77776.1 - 0.025 14.8 2.6 0.025 14.8 2.6 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger Prok-RING_4 PF14447.6 VDK77776.1 - 0.028 14.3 5.8 0.083 12.8 5.8 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 VDK77776.1 - 0.052 13.7 8.9 0.13 12.4 8.9 1.7 1 0 0 1 1 1 0 RING-variant domain DUF2709 PF10915.8 VDK77776.1 - 0.093 12.0 0.2 0.27 10.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2709) FANCL_C PF11793.8 VDK77776.1 - 0.1 12.8 7.9 0.47 10.7 7.2 2.5 2 1 0 2 2 1 0 FANCL C-terminal domain Uso1_p115_C PF04871.13 VDK77776.1 - 0.11 12.8 8.5 0.28 11.6 8.5 1.5 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Zn-ribbon_8 PF09723.10 VDK77776.1 - 0.12 12.5 1.9 0.42 10.8 1.9 1.9 1 0 0 1 1 1 0 Zinc ribbon domain Cnn_1N PF07989.11 VDK77776.1 - 0.78 9.9 8.8 6.6 7.0 0.1 2.7 3 0 0 3 3 2 0 Centrosomin N-terminal motif 1 zf-RING-like PF08746.11 VDK77776.1 - 1.9 8.9 8.4 4.8 7.6 8.4 1.8 1 0 0 1 1 1 0 RING-like domain HALZ PF02183.18 VDK77776.1 - 2.7 8.3 8.8 0.35 11.1 3.9 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 VDK77776.1 - 3.5 8.1 13.7 1.8 9.1 4.7 2.5 1 1 1 2 2 2 0 Cell division protein ZapB Ank_2 PF12796.7 VDK77777.1 - 4.5e-19 68.8 0.1 5.9e-09 36.4 0.0 3.5 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 VDK77777.1 - 1e-12 47.9 1.9 0.0019 18.6 0.1 5.5 6 0 0 6 6 6 2 Ankyrin repeat Ank_4 PF13637.6 VDK77777.1 - 1.1e-12 48.2 0.3 0.0015 19.0 0.1 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK77777.1 - 9.3e-12 44.1 1.7 0.0036 17.7 0.0 5.5 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 VDK77777.1 - 5.9e-07 29.6 0.5 0.00014 22.1 0.1 4.4 3 2 1 4 4 4 2 Ankyrin repeats (many copies) Neur_chan_LBD PF02931.23 VDK77793.1 - 2.2e-45 154.8 0.0 3.2e-45 154.2 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK77793.1 - 4.5e-28 98.9 0.0 6e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region LexA_DNA_bind PF01726.16 VDK77795.1 - 0.11 12.3 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 LexA DNA binding domain DUF2362 PF10154.9 VDK77797.1 - 5e-91 306.1 5.6 1.3e-54 186.0 2.0 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2362) TetR_C_24 PF17932.1 VDK77797.1 - 0.13 12.5 0.6 11 6.4 0.0 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain 7TMR-HDED PF07697.11 VDK77797.1 - 0.41 10.7 2.3 0.86 9.7 2.3 1.9 1 1 0 1 1 1 0 7TM-HD extracellular Hydrolase_4 PF12146.8 VDK77798.1 - 3.6e-18 65.7 0.0 3.4e-14 52.7 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK77798.1 - 1.6e-17 64.0 0.2 4.8e-12 46.1 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 VDK77798.1 - 8.2e-11 42.9 0.0 1.8e-10 41.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 VDK77798.1 - 9.2e-07 28.9 0.0 1.6e-06 28.2 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold LIP PF03583.14 VDK77798.1 - 0.0003 20.2 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 2 Secretory lipase DLH PF01738.18 VDK77798.1 - 0.0016 18.0 0.0 0.013 15.0 0.0 1.9 2 0 0 2 2 2 1 Dienelactone hydrolase family LIDHydrolase PF10230.9 VDK77798.1 - 0.0033 17.0 0.0 0.077 12.5 0.0 2.1 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Thioesterase PF00975.20 VDK77798.1 - 0.0047 17.1 0.0 0.0076 16.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.16 VDK77798.1 - 0.0053 16.6 0.0 0.67 9.7 0.0 2.4 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 VDK77798.1 - 0.02 14.8 0.1 0.051 13.5 0.1 1.5 1 1 0 1 1 1 0 Lipase (class 3) COesterase PF00135.28 VDK77798.1 - 0.06 12.2 0.0 0.18 10.6 0.0 1.6 2 0 0 2 2 2 0 Carboxylesterase family Peptidase_S15 PF02129.18 VDK77798.1 - 0.07 12.7 0.0 0.26 10.8 0.0 1.7 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) FSH1 PF03959.13 VDK77798.1 - 0.089 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) TIP120 PF08623.10 VDK77799.1 - 4.6e-61 205.5 11.6 5.1e-60 202.1 1.2 5.5 5 1 1 6 6 6 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 VDK77799.1 - 2.9e-14 53.2 11.4 0.026 14.9 0.0 8.8 6 2 4 10 10 10 4 HEAT repeats HEAT PF02985.22 VDK77799.1 - 1.2e-12 46.9 22.3 0.32 11.4 0.1 12.7 12 0 0 12 12 12 2 HEAT repeat HEAT_EZ PF13513.6 VDK77799.1 - 4.9e-09 36.5 16.1 2.9 8.5 0.0 10.8 11 0 0 11 11 11 2 HEAT-like repeat Cnd1 PF12717.7 VDK77799.1 - 7.3e-08 32.6 18.5 7.8e-05 22.8 0.1 6.6 4 2 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 VDK77799.1 - 3e-05 23.9 2.7 0.46 10.4 0.0 6.6 6 1 1 7 7 7 1 UME (NUC010) domain DUF3385 PF11865.8 VDK77799.1 - 0.0001 22.3 6.0 0.013 15.4 0.2 5.1 4 1 1 5 5 5 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 VDK77799.1 - 0.0009 18.9 11.5 0.081 12.5 0.1 6.2 4 2 2 6 6 6 1 CLASP N terminal ParcG PF10274.9 VDK77799.1 - 0.0019 18.4 16.1 0.15 12.2 0.1 6.7 5 2 2 7 7 7 1 Parkin co-regulated protein MMS19_N PF14500.6 VDK77799.1 - 0.037 13.6 0.1 0.037 13.6 0.1 6.5 6 2 2 9 9 9 0 Dos2-interacting transcription regulator of RNA-Pol-II Telomere_reg-2 PF10193.9 VDK77799.1 - 0.95 9.9 16.2 6 7.4 0.0 7.2 8 1 0 8 8 8 0 Telomere length regulation protein V-ATPase_H_C PF11698.8 VDK77799.1 - 1.5 9.0 7.7 0.87 9.7 0.3 4.6 4 1 0 4 4 4 0 V-ATPase subunit H Dopey_N PF04118.14 VDK77799.1 - 1.8 7.6 8.9 2.7 7.0 0.8 4.3 4 1 1 5 5 5 0 Dopey, N-terminal RTP1_C1 PF10363.9 VDK77799.1 - 3.5 7.8 9.1 1.7e+02 2.5 0.1 5.8 4 2 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Pkinase PF00069.25 VDK77800.1 - 2.4e-59 200.9 0.0 3.4e-59 200.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77800.1 - 3e-31 108.7 0.0 5.5e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK77800.1 - 2.1e-05 24.0 0.0 7.3e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDK77800.1 - 0.0054 15.6 0.0 0.0087 14.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK77800.1 - 0.0066 16.4 0.0 1.5 8.7 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 VDK77800.1 - 0.016 14.9 0.0 0.04 13.5 0.0 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 VDK77800.1 - 0.029 13.7 0.0 0.063 12.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 VDK77800.1 - 0.14 11.2 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 SIR2 PF02146.17 VDK77801.1 - 3.4e-46 157.4 0.0 2.4e-44 151.4 0.0 2.3 1 1 0 1 1 1 1 Sir2 family DUF3381 PF11861.8 VDK77801.1 - 1 9.1 13.8 0.13 12.1 4.9 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3381) Ndc1_Nup PF09531.10 VDK77803.1 - 3.1e-29 102.2 15.2 6.1e-28 97.9 13.4 2.4 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup LSM PF01423.22 VDK77804.1 - 1.1e-14 53.8 0.3 1.7e-14 53.3 0.3 1.3 1 0 0 1 1 1 1 LSM domain Borealin PF10512.9 VDK77807.1 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 Cell division cycle-associated protein 8 Ribosomal_L38e PF01781.18 VDK77808.1 - 2.1e-37 127.0 4.7 2.6e-37 126.7 4.7 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family Mus7 PF09462.10 VDK77808.1 - 0.021 13.7 0.1 0.022 13.6 0.1 1.1 1 0 0 1 1 1 0 Mus7/MMS22 family Neur_chan_LBD PF02931.23 VDK77809.1 - 2.4e-32 112.2 6.3 3.5e-32 111.6 6.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK77809.1 - 1.8e-07 31.5 5.1 5e-07 30.0 3.7 2.0 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region MFS_1 PF07690.16 VDK77809.1 - 0.9 8.4 8.3 0.15 11.0 3.9 1.7 2 0 0 2 2 2 0 Major Facilitator Superfamily ANF_receptor PF01094.28 VDK77826.1 - 2.1e-34 119.2 0.3 5.8e-29 101.3 0.1 2.2 2 0 0 2 2 2 2 Receptor family ligand binding region ANAPC_CDC26 PF10471.9 VDK77826.1 - 0.15 12.9 0.8 0.87 10.5 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 RRM_1 PF00076.22 VDK77828.1 - 0.0011 18.7 0.0 0.0018 18.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 VDK77830.1 - 1.8e-10 40.5 0.0 1.9e-08 34.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) wnt PF00110.19 VDK77833.1 - 6.3e-31 108.1 0.7 8e-31 107.8 0.7 1.0 1 0 0 1 1 1 1 wnt family Phospho_p8 PF10195.9 VDK77834.1 - 3.4 8.2 8.5 7.9 7.1 0.1 4.0 4 0 0 4 4 4 0 DNA-binding nuclear phosphoprotein p8 PCI PF01399.27 VDK77837.1 - 1e-21 77.4 1.6 1.7e-21 76.7 0.3 2.1 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 VDK77837.1 - 0.0012 18.7 1.1 21 5.4 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK77837.1 - 0.014 16.1 0.5 20 6.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK77837.1 - 0.07 13.0 5.9 0.34 10.8 0.7 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 VDK77837.1 - 0.13 12.6 3.9 4.4 7.7 0.5 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 VDK77837.1 - 0.13 12.4 7.7 0.34 11.1 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN6_N PF18055.1 VDK77837.1 - 0.41 11.0 11.7 16 5.8 0.0 3.4 1 1 2 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain C2 PF00168.30 VDK77840.1 - 2.3e-08 34.2 0.0 4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain UQ_con PF00179.26 VDK77841.1 - 8.4e-09 35.2 0.0 7.2e-08 32.2 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK77841.1 - 0.0033 17.1 0.0 0.0086 15.8 0.0 1.8 2 0 0 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 VDK77841.1 - 0.0054 17.0 0.1 2.2 8.6 0.2 2.4 2 0 0 2 2 2 2 RWD domain Josephin PF02099.17 VDK77841.1 - 0.09 12.9 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Josephin Peptidase_M48_N PF16491.5 VDK77844.1 - 5.9e-61 205.5 5.5 5.9e-61 205.5 5.5 1.7 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 VDK77844.1 - 7.6e-45 153.1 0.0 1.2e-44 152.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 DUF986 PF06173.12 VDK77844.1 - 0.69 10.0 6.8 0.27 11.3 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF986) La PF05383.17 VDK77846.1 - 1.2e-19 70.1 0.0 2.8e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 La domain RRM_3 PF08777.11 VDK77846.1 - 1.4e-18 66.8 2.6 1.4e-18 66.8 2.6 3.6 3 1 0 3 3 3 1 RNA binding motif RRM_1 PF00076.22 VDK77846.1 - 7.2e-11 41.8 11.0 3.2e-09 36.5 1.2 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRO8NT PF08082.11 VDK77846.1 - 0.0065 16.4 0.5 0.0065 16.4 0.5 2.2 2 1 1 3 3 3 1 PRO8NT (NUC069), PrP8 N-terminal domain Nup35_RRM_2 PF14605.6 VDK77846.1 - 0.0094 15.9 0.1 0.18 11.8 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif BRAP2 PF07576.12 VDK77846.1 - 0.018 15.2 0.6 0.046 13.9 0.6 1.7 1 0 0 1 1 1 0 BRCA1-associated protein 2 SAM_3 PF18016.1 VDK77846.1 - 0.087 12.6 0.1 2.8 7.8 0.0 2.5 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) PHM7_cyt PF14703.6 VDK77846.1 - 8.3 6.6 15.8 1.1 9.4 0.8 3.6 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter E1-E2_ATPase PF00122.20 VDK77853.1 - 4e-54 182.9 4.4 1.1e-52 178.2 0.1 3.0 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 VDK77853.1 - 1.7e-44 151.7 6.1 1.7e-44 151.7 6.1 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 VDK77853.1 - 8.3e-19 67.5 0.0 2e-18 66.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 VDK77853.1 - 1e-18 68.4 0.1 1.9e-17 64.3 0.1 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 VDK77853.1 - 1.9e-17 62.7 2.1 3.4e-17 61.9 0.1 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 VDK77853.1 - 2.9e-05 23.9 0.5 2.9e-05 23.9 0.5 2.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDK77853.1 - 0.00024 21.6 0.0 0.0016 18.9 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Glycos_transf_2 PF00535.26 VDK77854.1 - 1.1e-28 100.1 0.0 2.2e-28 99.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 VDK77854.1 - 1.9e-19 70.2 0.8 3.3e-19 69.4 0.8 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain SUI1 PF01253.22 VDK77854.1 - 5.3e-17 62.1 0.1 1.1e-16 61.1 0.1 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 Glyco_transf_7C PF02709.14 VDK77854.1 - 1.3e-06 27.9 0.0 3.1e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase RicinB_lectin_2 PF14200.6 VDK77854.1 - 0.00043 20.9 0.1 0.4 11.4 0.1 2.6 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Glyco_tranf_2_2 PF10111.9 VDK77854.1 - 0.0009 18.8 0.0 0.0033 16.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 ubiquitin PF00240.23 VDK77855.1 - 6e-05 22.7 0.6 0.0021 17.8 0.2 2.1 2 0 0 2 2 2 2 Ubiquitin family UTP25 PF06862.12 VDK77856.1 - 1.8e-123 412.8 8.3 2.8e-105 352.8 4.6 2.1 1 1 1 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 VDK77856.1 - 7.6e-05 22.5 0.1 0.00014 21.7 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase CDK2AP PF09806.9 VDK77858.1 - 1.2e-17 64.8 0.1 1.4e-17 64.5 0.1 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase 2-associated protein WD40 PF00400.32 VDK77859.1 - 4.1e-05 24.3 2.2 0.11 13.4 0.3 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Rgp1 PF08737.10 VDK77862.1 - 8.9e-37 127.2 2.7 1.1e-19 71.0 0.2 2.4 1 1 1 2 2 2 2 Rgp1 Arrestin_C PF02752.22 VDK77862.1 - 0.00013 22.4 0.1 0.12 12.8 0.1 2.4 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 VDK77862.1 - 0.052 13.6 0.1 16 5.5 0.0 2.8 3 0 0 3 3 3 0 Arrestin (or S-antigen), N-terminal domain Cys_box PF17869.1 VDK77862.1 - 0.053 13.7 0.7 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 Anosmin cysteine rich domain CPSase_L_D2 PF02786.17 VDK77864.1 - 0.037 13.5 0.1 0.059 12.8 0.1 1.2 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain LIAS_N PF16881.5 VDK77866.1 - 2.2e-21 76.3 0.1 4.8e-21 75.2 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 VDK77866.1 - 1.1e-14 55.1 0.0 2.6e-14 53.9 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily COPR5 PF15340.6 VDK77870.1 - 1.5 9.4 7.8 1.2 9.7 6.3 1.6 1 1 0 1 1 1 0 Cooperator of PRMT5 family Apt1 PF10351.9 VDK77870.1 - 4.8 5.9 19.3 5.6 5.7 19.3 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain MutS_V PF00488.21 VDK77879.1 - 5.3e-69 232.0 0.1 8.9e-69 231.3 0.1 1.3 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 VDK77879.1 - 5.6e-34 116.8 0.0 1.3e-33 115.6 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 VDK77879.1 - 3.4e-30 105.7 0.1 9.8e-30 104.2 0.1 1.9 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 VDK77879.1 - 1.4e-11 44.8 0.0 1.2e-10 41.8 0.0 2.5 1 1 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 VDK77879.1 - 3.4e-08 33.7 1.0 3.3e-07 30.6 0.2 2.5 2 0 0 2 2 2 1 MutS family domain IV AAA_29 PF13555.6 VDK77879.1 - 0.19 11.5 0.2 0.42 10.4 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain HBS1_N PF08938.10 VDK77880.1 - 0.0021 18.3 0.5 0.0045 17.3 0.5 1.5 1 0 0 1 1 1 1 HBS1 N-terminus API5 PF05918.11 VDK77880.1 - 0.1 11.4 3.1 0.23 10.2 3.1 1.5 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Peptidase_M24 PF00557.24 VDK77881.1 - 9.6e-41 139.8 0.1 1.3e-40 139.3 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 VDK77881.1 - 5.2e-26 90.8 0.0 8.5e-26 90.1 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain CUB PF00431.20 VDK77882.1 - 8.3e-22 77.6 0.8 1.2e-12 48.2 0.0 3.4 3 1 0 3 3 3 2 CUB domain Phage_Gp23 PF10669.9 VDK77882.1 - 0.0012 19.1 0.7 0.0041 17.4 0.1 2.0 2 0 0 2 2 2 1 Protein gp23 (Bacteriophage A118) Ldl_recept_a PF00057.18 VDK77882.1 - 0.003 17.8 12.6 0.011 16.0 6.1 2.6 1 1 1 2 2 2 2 Low-density lipoprotein receptor domain class A EphA2_TM PF14575.6 VDK77882.1 - 0.034 15.0 1.1 2.1 9.3 0.2 2.6 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SCF PF02404.15 VDK77882.1 - 0.091 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Stem cell factor Pkinase PF00069.25 VDK77885.1 - 8.1e-67 225.4 0.0 1.7e-66 224.3 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77885.1 - 2.4e-36 125.3 0.0 5.1e-36 124.3 0.0 1.5 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK77885.1 - 4.1e-09 36.2 0.0 3.8e-08 33.0 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 VDK77885.1 - 0.13 11.6 0.1 0.22 10.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BBP1_N PF15271.6 VDK77885.1 - 7.7 7.3 7.0 0.66 10.8 1.5 2.0 2 0 0 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein tRNA-synt_1 PF00133.22 VDK77886.1 - 1.2e-33 116.3 4.8 2e-15 56.1 0.2 4.8 3 1 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 VDK77886.1 - 3.4e-21 75.4 0.0 1.4e-15 56.9 0.0 3.8 3 1 1 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 VDK77886.1 - 1e-05 25.5 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Hexokinase_2 PF03727.16 VDK77887.1 - 2.1e-85 286.0 0.0 3.1e-85 285.4 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 VDK77887.1 - 4.2e-72 242.2 0.0 9.1e-72 241.1 0.0 1.6 1 0 0 1 1 1 1 Hexokinase Glyco_hydro_62 PF03664.13 VDK77887.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 62 NPA PF16469.5 VDK77895.1 - 2.4e-76 254.2 39.7 9.7e-26 90.8 11.7 5.0 5 0 0 5 5 5 4 Nematode polyprotein allergen ABA-1 TFIID_20kDa PF03847.13 VDK77895.1 - 0.0053 17.2 1.9 0.016 15.7 0.5 2.5 2 1 1 3 3 3 1 Transcription initiation factor TFIID subunit A FGGY_N PF00370.21 VDK77895.1 - 0.011 15.3 0.2 0.26 10.8 0.1 2.3 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain ZT_dimer PF16916.5 VDK77895.1 - 0.053 13.7 1.9 0.38 10.9 0.1 2.8 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter Atypical_Card PF18461.1 VDK77895.1 - 1.3 9.2 5.3 13 6.0 0.1 3.6 3 1 1 4 4 4 0 Atypical caspase recruitment domain NPA PF16469.5 VDK77897.1 - 1.5e-60 203.2 11.2 4e-24 85.5 6.1 3.2 3 0 0 3 3 3 3 Nematode polyprotein allergen ABA-1 Laminin_EGF PF00053.24 VDK77897.1 - 2.5e-11 43.5 53.5 4.9e-07 29.8 18.6 3.5 3 0 0 3 3 3 2 Laminin EGF domain WbqC PF08889.11 VDK77897.1 - 0.27 11.1 1.8 0.52 10.2 0.1 2.1 2 0 0 2 2 2 0 WbqC-like protein family CDC37_N PF03234.14 VDK77897.1 - 1.8 9.5 4.6 2.6 9.0 3.0 2.1 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding GTP_cyclohydroI PF01227.22 VDK77898.1 - 8.6e-56 188.2 1.2 5.4e-31 107.4 0.0 2.1 1 1 1 2 2 2 2 GTP cyclohydrolase I Ank_5 PF13857.6 VDK77899.1 - 7.9e-08 32.4 0.0 2.1e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK77899.1 - 1e-07 32.4 0.0 3.2e-07 30.8 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 VDK77899.1 - 2.4e-06 27.7 0.0 0.0011 19.4 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 VDK77899.1 - 0.00023 21.4 0.0 0.0015 18.9 0.0 2.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 VDK77899.1 - 0.00032 21.2 0.0 0.00075 20.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) DUF4503 PF14951.6 VDK77899.1 - 0.016 13.7 2.4 0.019 13.4 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) CUB PF00431.20 VDK77902.1 - 2.1e-301 977.6 46.6 4.1e-24 85.0 0.0 29.0 28 1 0 28 28 28 26 CUB domain EGF PF00008.27 VDK77902.1 - 5.3e-17 61.8 94.3 2.7e-08 33.9 4.6 9.3 8 0 0 8 8 8 5 EGF-like domain EGF_CA PF07645.15 VDK77902.1 - 1.9e-11 44.0 95.4 3.6e-08 33.5 5.6 9.2 5 3 3 8 8 8 4 Calcium-binding EGF domain CUB_2 PF02408.20 VDK77902.1 - 1.1e-07 31.6 32.1 0.18 11.6 0.0 12.3 16 0 0 16 16 16 4 CUB-like domain hEGF PF12661.7 VDK77902.1 - 3.5e-06 27.4 10.2 3.4e-05 24.3 1.4 9.9 8 0 0 8 8 8 3 Human growth factor-like EGF cEGF PF12662.7 VDK77902.1 - 4.4e-05 23.3 4.0 0.0018 18.1 1.2 8.4 8 0 0 8 8 8 3 Complement Clr-like EGF-like EGF_3 PF12947.7 VDK77902.1 - 0.00036 20.7 94.9 0.046 13.9 1.4 9.4 8 0 0 8 8 8 5 EGF domain EGF_2 PF07974.13 VDK77902.1 - 0.0029 17.9 7.7 0.0029 17.9 7.7 8.0 7 0 0 7 7 7 3 EGF-like domain PCMT PF01135.19 VDK77903.1 - 7.5e-140 463.6 0.0 1.4e-74 250.4 0.0 2.0 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 VDK77903.1 - 6e-15 55.3 0.0 1.1e-06 28.5 0.1 2.7 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_32 PF13679.6 VDK77903.1 - 6.1e-10 39.3 0.3 0.0013 18.8 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain PrmA PF06325.13 VDK77903.1 - 1.7e-09 37.5 1.0 0.00063 19.2 0.1 2.2 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 VDK77903.1 - 1.1e-08 35.6 0.0 0.0064 17.2 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 VDK77903.1 - 3.9e-07 29.8 0.2 0.0071 15.9 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_11 PF08241.12 VDK77903.1 - 4.5e-07 30.4 0.1 0.033 14.8 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_3 PF01596.17 VDK77903.1 - 1.5e-06 27.6 0.2 0.015 14.5 0.0 2.9 4 0 0 4 4 3 2 O-methyltransferase Methyltransf_23 PF13489.6 VDK77903.1 - 2e-06 27.8 0.0 0.021 14.7 0.0 3.0 2 1 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 VDK77903.1 - 4.9e-06 26.0 0.1 0.046 13.1 0.1 2.3 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 VDK77903.1 - 6.6e-06 26.1 0.0 0.031 14.2 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_16 PF10294.9 VDK77903.1 - 6.2e-05 22.8 0.4 0.19 11.4 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase GCD14 PF08704.10 VDK77903.1 - 0.00016 21.5 0.0 0.22 11.1 0.0 2.3 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit Methyltransf_4 PF02390.17 VDK77903.1 - 0.00025 20.5 0.0 0.77 9.2 0.0 2.4 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_24 PF13578.6 VDK77903.1 - 0.00061 20.8 0.0 1.7 9.7 0.0 2.9 3 0 0 3 3 2 2 Methyltransferase domain CMAS PF02353.20 VDK77903.1 - 0.00063 19.1 0.1 1.3 8.3 0.0 2.5 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 VDK77903.1 - 0.00065 19.3 0.1 1.1 8.8 0.0 2.3 2 0 0 2 2 2 2 Histone methylation protein DOT1 FtsJ PF01728.19 VDK77903.1 - 0.00073 19.7 0.0 1.7 8.7 0.0 2.6 2 0 0 2 2 2 2 FtsJ-like methyltransferase Fibrillarin PF01269.17 VDK77903.1 - 0.00077 18.6 0.3 0.4 9.8 0.0 2.4 2 0 0 2 2 2 2 Fibrillarin RrnaAD PF00398.20 VDK77903.1 - 0.0018 17.4 0.0 0.22 10.6 0.0 2.2 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Methyltransf_9 PF08003.11 VDK77903.1 - 0.002 17.1 0.2 1.4 7.7 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1698) ACP_syn_III_C PF08541.10 VDK77903.1 - 0.015 15.5 0.0 6.3 7.0 0.0 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Methyltr_RsmB-F PF01189.17 VDK77903.1 - 0.022 14.4 0.0 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F zf-RING_4 PF14570.6 VDK77903.1 - 0.13 12.0 1.7 0.29 11.0 1.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain CAP_GLY PF01302.25 VDK77904.1 - 8.2e-24 83.4 0.9 1.2e-23 82.9 0.9 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 VDK77904.1 - 1.5e-15 57.4 0.1 1e-14 54.7 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain SERTA PF06031.13 VDK77905.1 - 6.3e-05 22.6 0.9 6.3e-05 22.6 0.9 1.8 2 0 0 2 2 2 1 SERTA motif PAP_central PF04928.17 VDK77909.1 - 4.1e-104 347.0 0.0 7.2e-104 346.2 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 VDK77909.1 - 6.8e-26 90.9 0.2 9.7e-17 61.1 0.0 2.7 2 0 0 2 2 2 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 VDK77909.1 - 1.4e-09 38.1 0.0 3e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF3715 PF12509.8 VDK77910.1 - 1.2e-05 25.4 0.4 5.3e-05 23.2 0.0 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3715) BRCA-2_OB3 PF09104.10 VDK77910.1 - 0.11 12.1 0.0 0.3 10.7 0.0 1.7 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 PDZ_6 PF17820.1 VDK77912.1 - 7.1e-16 57.8 0.0 5.5e-10 39.0 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 VDK77912.1 - 1.2e-15 57.6 0.5 1.1e-08 35.2 0.1 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDK77912.1 - 1.3e-09 38.2 0.0 3.3e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 PDZ domain LCM PF04072.14 VDK77912.1 - 0.07 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Leucine carboxyl methyltransferase DUF3394 PF11874.8 VDK77912.1 - 0.13 12.0 0.2 1.9 8.1 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3394) FlgO PF17680.1 VDK77912.1 - 0.14 11.9 0.0 0.3 10.8 0.0 1.5 1 0 0 1 1 1 0 FlgO protein KH_8 PF17903.1 VDK77914.1 - 2.8e-32 110.6 0.1 5.9e-32 109.6 0.1 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 VDK77914.1 - 0.011 15.6 0.1 0.028 14.3 0.1 1.8 1 0 0 1 1 1 0 KH domain KH_4 PF13083.6 VDK77914.1 - 0.035 14.0 0.2 0.083 12.8 0.2 1.6 1 0 0 1 1 1 0 KH domain PWI PF01480.17 VDK77917.1 - 3.2e-15 56.2 4.4 3.8e-15 56.0 0.5 2.7 3 0 0 3 3 3 1 PWI domain RRM_1 PF00076.22 VDK77917.1 - 6e-07 29.2 0.0 1.3e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_primase_lrg PF04104.14 VDK77918.1 - 8.7e-82 274.5 0.1 1.5e-81 273.7 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit AAA PF00004.29 VDK77919.1 - 1.1e-36 126.2 0.0 2.1e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 VDK77919.1 - 1.7e-07 31.3 0.0 9.7e-07 28.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 VDK77919.1 - 3.9e-06 27.3 0.3 0.00036 20.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 VDK77919.1 - 5.2e-06 26.3 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK77919.1 - 0.00012 22.4 0.1 0.0036 17.6 0.1 2.7 1 1 2 3 3 3 1 AAA domain AAA_14 PF13173.6 VDK77919.1 - 0.00017 21.6 0.0 0.00036 20.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_lid_3 PF17862.1 VDK77919.1 - 0.00026 20.7 0.1 0.00049 19.8 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain RNA_helicase PF00910.22 VDK77919.1 - 0.00054 20.3 0.0 0.0019 18.6 0.0 2.0 2 1 0 2 2 1 1 RNA helicase AAA_2 PF07724.14 VDK77919.1 - 0.0007 19.7 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TniB PF05621.11 VDK77919.1 - 0.00096 18.6 0.0 0.14 11.6 0.0 2.4 1 1 0 2 2 2 1 Bacterial TniB protein NACHT PF05729.12 VDK77919.1 - 0.0025 17.8 0.1 0.055 13.4 0.0 2.2 1 1 1 2 2 2 1 NACHT domain AAA_25 PF13481.6 VDK77919.1 - 0.0044 16.6 0.3 0.58 9.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 VDK77919.1 - 0.007 15.8 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 VDK77919.1 - 0.0077 16.0 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 VDK77919.1 - 0.0092 16.1 0.0 0.88 9.7 0.0 2.3 2 0 0 2 2 2 1 Shikimate kinase Rad17 PF03215.15 VDK77919.1 - 0.01 15.8 0.1 0.049 13.6 0.1 2.0 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 VDK77919.1 - 0.012 16.2 0.0 0.021 15.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 VDK77919.1 - 0.015 15.8 0.0 0.043 14.3 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 VDK77919.1 - 0.017 14.7 0.0 0.047 13.2 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 VDK77919.1 - 0.02 14.6 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 VDK77919.1 - 0.03 13.5 0.0 0.061 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Glyco_hydro_3_C PF01915.22 VDK77919.1 - 0.035 14.1 0.0 0.051 13.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain AAA_33 PF13671.6 VDK77919.1 - 0.036 14.2 0.0 0.067 13.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 VDK77919.1 - 0.041 13.7 0.0 0.097 12.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 VDK77919.1 - 0.047 13.4 0.0 0.11 12.2 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 VDK77919.1 - 0.047 13.7 0.0 0.087 12.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 VDK77919.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain DAP3 PF10236.9 VDK77919.1 - 0.055 12.6 0.0 0.087 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ATPase_2 PF01637.18 VDK77919.1 - 0.055 13.4 0.1 0.28 11.0 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 VDK77919.1 - 0.067 12.4 0.1 3.2 6.9 0.0 2.3 1 1 0 2 2 2 0 KAP family P-loop domain Oxidored_nitro PF00148.19 VDK77919.1 - 0.079 11.7 0.0 0.21 10.3 0.0 1.6 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase AAA_21 PF13304.6 VDK77919.1 - 0.12 12.2 0.2 8.8 6.0 0.0 2.2 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 VDK77919.1 - 0.12 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ATPase PF06745.13 VDK77919.1 - 0.12 11.7 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 KaiC CPT PF07931.12 VDK77919.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Parvo_NS1 PF01057.17 VDK77919.1 - 0.15 11.1 0.0 0.28 10.2 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 zf-CCCH PF00642.24 VDK77920.1 - 1.1e-07 31.5 3.8 1.1e-07 31.5 3.8 1.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK77920.1 - 2.3e-06 27.5 5.0 2.3e-06 27.5 5.0 2.0 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 VDK77920.1 - 1.3e-05 24.9 4.2 2.4e-05 24.0 4.2 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 VDK77920.1 - 0.00085 20.0 1.7 0.0018 18.9 1.5 1.5 1 1 0 1 1 1 1 Torus domain zf-CCCH_2 PF14608.6 VDK77920.1 - 0.0046 17.4 5.9 0.013 16.0 5.9 1.8 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger Ribosomal_L1 PF00687.21 VDK77921.1 - 3e-24 85.9 0.8 3e-24 85.9 0.8 2.2 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family Telomere_Sde2_2 PF13297.6 VDK77921.1 - 9.4e-23 79.6 0.1 2.9e-22 78.1 0.1 1.9 1 0 0 1 1 1 1 Telomere stability C-terminal Sde2_N_Ubi PF13019.6 VDK77921.1 - 9.3e-15 54.8 4.6 9.3e-15 54.8 4.6 2.5 3 0 0 3 3 3 1 Silencing defective 2 N-terminal ubiquitin domain G-alpha PF00503.20 VDK77922.1 - 2.4e-111 372.3 6.1 3.1e-111 372.0 6.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 VDK77922.1 - 6.4e-14 51.8 2.3 7.2e-11 41.8 0.7 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 VDK77922.1 - 0.0015 18.7 0.2 1.5 9.1 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK77922.1 - 0.034 13.7 1.9 5.3 6.6 0.0 2.6 2 1 0 2 2 2 0 Ras family ABC_tran PF00005.27 VDK77922.1 - 0.084 13.4 0.0 0.23 12.0 0.0 1.8 1 0 0 1 1 1 0 ABC transporter Pkinase PF00069.25 VDK77926.1 - 1.1e-33 116.8 0.0 1.3e-33 116.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77926.1 - 1.8e-16 60.3 0.0 2.3e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Aldedh PF00171.22 VDK77928.1 - 2.6e-100 336.1 0.0 5.6e-100 335.0 0.0 1.4 2 0 0 2 2 2 1 Aldehyde dehydrogenase family TPR_2 PF07719.17 VDK77928.1 - 2.2e-11 43.0 2.4 0.027 14.6 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 VDK77928.1 - 6.5e-09 36.3 0.0 0.0069 17.0 0.1 3.6 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK77928.1 - 1e-08 34.7 0.4 0.19 12.0 0.0 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 VDK77928.1 - 4.3e-07 30.4 0.6 0.021 15.4 0.1 4.2 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 VDK77928.1 - 1.9e-05 25.1 5.4 0.073 13.9 0.2 5.4 2 2 4 6 6 6 2 Tetratricopeptide repeat NARP1 PF12569.8 VDK77928.1 - 6.9e-05 21.9 1.8 0.017 14.1 0.1 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 Alkyl_sulf_dimr PF14863.6 VDK77928.1 - 7.1e-05 23.3 0.1 0.18 12.2 0.1 2.6 1 1 1 2 2 2 2 Alkyl sulfatase dimerisation TPR_1 PF00515.28 VDK77928.1 - 0.00099 18.8 1.1 2 8.4 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 VDK77928.1 - 0.0065 17.0 0.4 79 4.2 0.1 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK77928.1 - 0.0099 15.8 2.6 8 6.7 0.1 4.8 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK77928.1 - 0.048 13.8 1.4 3.3 7.9 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Steroid_dh PF02544.16 VDK77930.1 - 1.4e-17 64.1 4.5 1.4e-17 64.1 4.5 2.0 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 VDK77930.1 - 0.0025 18.2 1.3 0.0025 18.2 1.3 2.8 2 2 0 3 3 3 1 Phospholipid methyltransferase Alpha-amyl_C PF09071.10 VDK77930.1 - 0.0041 16.9 0.3 0.034 14.0 0.1 2.4 2 0 0 2 2 2 1 Alpha-amylase, C terminal SE PF08491.10 VDK77930.1 - 0.34 9.9 6.1 2.2 7.3 0.3 2.8 2 1 0 3 3 3 0 Squalene epoxidase Trehalase PF01204.18 VDK77933.1 - 1.1e-37 130.0 0.1 1.5e-37 129.7 0.1 1.2 1 0 0 1 1 1 1 Trehalase HYLS1_C PF15311.6 VDK77933.1 - 0.095 13.5 0.1 0.22 12.3 0.1 1.6 1 0 0 1 1 1 0 Hydrolethalus syndrome protein 1 C-terminus Trehalase PF01204.18 VDK77934.1 - 1.3e-65 222.3 0.3 1.5e-65 222.0 0.3 1.0 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.16 VDK77934.1 - 0.0064 15.3 3.8 0.26 10.0 0.1 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 63 C-terminal domain Aminotran_1_2 PF00155.21 VDK77935.1 - 2e-25 89.8 0.0 2.4e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DUF4477 PF14780.6 VDK77936.1 - 4e-16 59.2 5.6 5.9e-16 58.7 5.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) PCI PF01399.27 VDK77939.1 - 7.1e-13 49.0 0.4 2.1e-12 47.5 0.1 2.0 2 0 0 2 2 2 1 PCI domain STAT_int PF02865.17 VDK77939.1 - 0.014 15.9 0.7 0.033 14.6 0.1 2.0 2 0 0 2 2 2 0 STAT protein, protein interaction domain VSG_B PF13206.6 VDK77941.1 - 0.23 10.7 4.1 0.29 10.3 4.1 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain LMBR1 PF04791.16 VDK77941.1 - 3.2 6.6 4.7 1.7 7.5 3.2 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein MIS13 PF08202.11 VDK77941.1 - 3.7 6.7 22.3 0.069 12.4 7.5 2.8 2 2 1 3 3 3 0 Mis12-Mtw1 protein family FapA PF03961.13 VDK77941.1 - 9.3 4.7 15.4 0.22 10.1 4.0 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A GILT PF03227.16 VDK77944.1 - 7.7e-27 93.6 0.8 1.4e-26 92.8 0.8 1.5 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) SapA PF02199.15 VDK77944.1 - 0.002 18.4 2.6 0.002 18.4 2.6 2.2 2 0 0 2 2 2 1 Saposin A-type domain JSRP PF15312.6 VDK77944.1 - 0.15 12.0 4.1 12 6.0 2.7 3.0 2 1 0 2 2 2 0 Junctional sarcoplasmic reticulum protein DUF2405 PF10293.9 VDK77946.1 - 0.018 15.0 0.1 0.078 12.9 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2405) GCP_C_terminal PF04130.13 VDK77946.1 - 0.022 14.3 0.2 0.022 14.3 0.2 2.1 2 1 0 2 2 2 0 Gamma tubulin complex component C-terminal Fzo_mitofusin PF04799.13 VDK77947.1 - 2.8e-49 166.8 0.1 1.6e-48 164.3 0.0 2.3 2 0 0 2 2 2 1 fzo-like conserved region Dynamin_N PF00350.23 VDK77947.1 - 7.9e-25 87.8 0.0 3.1e-24 85.9 0.0 2.1 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 VDK77947.1 - 8e-07 29.1 0.0 3.3e-06 27.2 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 VDK77947.1 - 0.01 15.2 0.0 0.15 11.4 0.0 2.5 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 VDK77947.1 - 0.081 12.8 1.1 0.61 10.0 0.0 2.8 4 0 0 4 4 4 0 RsgA GTPase KxDL PF10241.9 VDK77947.1 - 9.6 6.6 9.8 25 5.2 0.3 4.1 4 1 1 5 5 5 0 Uncharacterized conserved protein Glutaredoxin PF00462.24 VDK77957.1 - 7.7e-35 118.9 0.0 1.5e-15 57.2 0.0 3.2 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 VDK77957.1 - 4.2e-12 46.0 0.1 9.1e-12 44.9 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin DIM1 PF02966.16 VDK77957.1 - 0.00092 19.0 0.1 0.0017 18.2 0.1 1.4 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_2 PF13098.6 VDK77957.1 - 0.0014 19.1 0.1 0.37 11.3 0.2 3.3 2 1 0 2 2 2 1 Thioredoxin-like domain HyaE PF07449.11 VDK77957.1 - 0.0076 16.2 0.0 0.095 12.7 0.0 2.5 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 VDK77957.1 - 0.018 14.8 0.0 1.8 8.3 0.1 2.9 3 0 0 3 3 3 0 F plasmid transfer operon protein Val_tRNA-synt_C PF10458.9 VDK77957.1 - 0.032 14.5 0.0 14 6.1 0.0 3.1 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm Fumerase_C PF05683.12 VDK77957.1 - 0.11 11.7 0.0 8.5 5.6 0.0 2.2 2 0 0 2 2 2 0 Fumarase C-terminus F-box PF00646.33 VDK77958.1 - 4.2e-08 32.9 1.3 3e-06 27.0 0.0 3.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 VDK77958.1 - 3.3e-05 23.7 0.5 3.3e-05 23.7 0.5 3.0 3 1 0 3 3 3 1 F-box-like LysM PF01476.20 VDK77962.1 - 2.1e-08 34.1 0.0 5.2e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 LysM domain VIT PF08487.10 VDK77962.1 - 0.076 13.2 0.3 0.71 10.1 0.0 2.6 1 1 1 2 2 2 0 Vault protein inter-alpha-trypsin domain TLD PF07534.16 VDK77963.1 - 1.8e-28 99.5 0.4 3.4e-28 98.6 0.4 1.5 1 0 0 1 1 1 1 TLD F-box-like PF12937.7 VDK77964.1 - 0.0018 18.1 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like TPR_3 PF07720.12 VDK77976.1 - 0.074 13.1 0.0 0.099 12.7 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-CCCH PF00642.24 VDK77977.1 - 9.1e-06 25.5 16.5 5.9e-05 22.9 4.7 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 VDK77977.1 - 0.00015 21.6 0.1 0.00024 20.8 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 VDK77977.1 - 0.0036 18.0 3.1 0.036 14.8 0.4 2.4 2 0 0 2 2 2 1 Torus domain zf-CCCH_3 PF15663.5 VDK77977.1 - 0.0063 16.7 3.1 1.2 9.4 0.3 2.3 2 0 0 2 2 2 2 Zinc-finger containing family zf_CCCH_4 PF18345.1 VDK77977.1 - 0.012 15.6 3.1 0.012 15.6 3.1 2.6 2 0 0 2 2 2 0 Zinc finger domain Nup35_RRM_2 PF14605.6 VDK77977.1 - 0.016 15.2 0.1 0.042 13.8 0.1 1.8 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ribosomal_L9_N PF01281.19 VDK77978.1 - 3.2e-13 49.0 0.1 5.4e-13 48.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain SLC35F PF06027.12 VDK77980.1 - 1.3e-109 366.4 27.1 1.6e-109 366.0 27.1 1.1 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 VDK77980.1 - 2.7e-11 43.8 35.7 5.6e-06 26.6 18.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 VDK77980.1 - 1.8e-09 37.0 4.5 1.8e-09 37.0 4.5 2.3 1 1 1 3 3 3 2 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 VDK77980.1 - 5.7e-09 35.6 21.2 1.1e-08 34.6 21.2 1.4 1 1 0 1 1 1 1 UAA transporter family PRD1_DD PF11087.8 VDK77980.1 - 4.3 7.1 5.9 3.2 7.5 0.4 2.5 2 0 0 2 2 2 0 PRD1 phage membrane DNA delivery Hexokinase_2 PF03727.16 VDK77982.1 - 2.7e-82 275.8 0.0 4e-82 275.2 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 VDK77982.1 - 2.1e-70 236.7 0.0 2.8e-70 236.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Ldh_2 PF02615.14 VDK77983.1 - 2.1e-105 352.6 0.6 2.8e-105 352.2 0.6 1.2 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Ala_racemase_C PF00842.21 VDK77983.1 - 0.062 13.1 0.0 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 Alanine racemase, C-terminal domain CLP1_N PF16573.5 VDK77987.1 - 0.031 14.5 0.1 0.11 12.7 0.0 1.9 2 0 0 2 2 2 0 N-terminal beta-sandwich domain of polyadenylation factor DUF2719 PF10891.8 VDK77987.1 - 0.12 12.3 0.1 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2719) MAM PF00629.23 VDK77990.1 - 4.7e-11 42.9 1.7 2.2e-10 40.7 0.1 2.5 3 0 0 3 3 3 1 MAM domain, meprin/A5/mu Hydrolase_4 PF12146.8 VDK77991.1 - 8.6e-15 54.7 0.1 2.8e-08 33.3 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK77991.1 - 8.9e-13 48.5 0.5 3.7e-06 26.8 0.2 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 VDK77991.1 - 1.2e-08 35.8 0.9 2.8e-05 24.8 0.1 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 VDK77991.1 - 4.6e-05 23.0 0.0 0.0025 17.3 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF818 PF05677.12 VDK77991.1 - 0.00037 19.5 0.4 0.0019 17.2 0.1 1.9 2 0 0 2 2 2 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.13 VDK77991.1 - 0.0018 18.0 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 VDK77991.1 - 0.019 14.8 0.0 0.063 13.1 0.0 1.8 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.18 VDK77991.1 - 0.023 14.3 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family BAAT_C PF08840.11 VDK77991.1 - 0.1 12.5 0.1 11 5.8 0.1 2.2 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal UPF0227 PF05728.12 VDK77991.1 - 0.19 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) PAN_1 PF00024.26 VDK77992.1 - 1.4e-11 44.1 20.2 0.00017 21.5 0.9 3.6 3 0 0 3 3 3 3 PAN domain Pkinase PF00069.25 VDK77995.1 - 2.6e-67 227.0 0.0 4.8e-67 226.1 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK77995.1 - 4.8e-32 111.3 0.0 7.1e-32 110.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK77995.1 - 1.7e-05 24.0 0.7 3.7e-05 22.9 0.1 1.8 2 1 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 VDK77995.1 - 2e-05 24.0 0.0 9.3e-05 21.9 0.0 1.9 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 VDK77995.1 - 0.0081 16.1 0.1 0.038 13.9 0.1 1.8 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 VDK77995.1 - 0.011 15.2 0.1 0.046 13.1 0.1 2.0 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 VDK77995.1 - 0.029 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 VDK77995.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF1768 PF08719.11 VDK78009.1 - 1e-11 45.4 0.0 7.6e-08 32.8 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF1768) DUF1768 PF08719.11 VDK78011.1 - 8.8e-12 45.6 0.0 1.8e-05 25.1 0.0 2.9 2 1 0 2 2 2 2 Domain of unknown function (DUF1768) SnoaL_3 PF13474.6 VDK78011.1 - 0.076 13.3 0.1 0.22 11.8 0.1 1.7 1 0 0 1 1 1 0 SnoaL-like domain DUF2457 PF10446.9 VDK78011.1 - 2.9 7.0 14.4 4.7 6.3 14.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Microcephalin PF12258.8 VDK78011.1 - 4.4 6.4 12.4 6.6 5.9 12.4 1.2 1 0 0 1 1 1 0 Microcephalin protein FAM76 PF16046.5 VDK78012.1 - 0.01 15.2 6.6 0.015 14.7 6.6 1.2 1 0 0 1 1 1 0 FAM76 protein TAFII55_N PF04658.13 VDK78013.1 - 1.4e-55 187.4 1.9 1.8e-55 187.0 1.9 1.1 1 0 0 1 1 1 1 TAFII55 protein conserved region Rad51 PF08423.11 VDK78016.1 - 9.1e-105 349.5 0.1 1.2e-104 349.2 0.1 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 VDK78016.1 - 4.8e-09 36.1 0.1 1.3e-08 34.6 0.1 1.6 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 VDK78016.1 - 4.7e-07 29.6 0.0 7.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 VDK78016.1 - 3.5e-06 27.5 0.6 9.2e-06 26.2 0.1 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 VDK78016.1 - 1.8e-05 24.2 2.0 0.00011 21.7 2.0 2.2 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 VDK78016.1 - 0.0042 16.4 0.7 0.029 13.7 0.7 2.3 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 VDK78016.1 - 0.015 15.0 0.3 0.034 13.9 0.3 1.7 1 1 0 1 1 1 0 AAA domain PAXNEB PF05625.11 VDK78016.1 - 0.093 11.8 0.0 0.48 9.5 0.0 1.9 2 0 0 2 2 2 0 PAXNEB protein Sulfate_transp PF00916.20 VDK78021.1 - 9.1e-105 350.5 18.2 1.3e-104 350.0 18.2 1.2 1 0 0 1 1 1 1 Sulfate permease family Metallophos PF00149.28 VDK78021.1 - 1.3e-39 136.8 0.6 2.2e-39 136.1 0.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STAS PF01740.21 VDK78021.1 - 6.7e-18 64.4 0.2 1.3e-17 63.5 0.2 1.4 1 0 0 1 1 1 1 STAS domain STPPase_N PF16891.5 VDK78021.1 - 6e-13 49.0 0.0 1.7e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain STAS_2 PF13466.6 VDK78021.1 - 0.12 12.8 0.0 0.46 10.9 0.0 2.0 2 0 0 2 2 2 0 STAS domain SHP PF03579.13 VDK78024.1 - 0.13 12.3 1.1 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 Small hydrophobic protein QVR PF17064.5 VDK78024.1 - 0.18 12.1 8.4 0.19 12.0 6.1 2.2 2 1 0 2 2 2 0 Sleepless protein DUF753 PF05444.12 VDK78024.1 - 1.4 8.9 9.4 0.5 10.3 5.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF753) SMYLE_N PF18615.1 VDK78025.1 - 0.0034 17.0 0.8 0.0034 17.0 0.8 1.8 2 0 0 2 2 2 1 Short myomegalin-like EB1 binding proteins, N-terminal domain PEHE PF15275.6 VDK78025.1 - 0.27 11.9 0.0 0.27 11.9 0.0 3.3 4 0 0 4 4 4 0 PEHE domain Hat1_N PF10394.9 VDK78027.1 - 3e-35 121.8 0.6 3e-35 121.8 0.6 1.8 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 VDK78027.1 - 0.0053 17.0 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family ISP3_C PF18045.1 VDK78040.1 - 0.016 15.1 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 ISP3 C-terminal ISP1_C PF18161.1 VDK78040.1 - 0.06 13.3 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 ISP1 C-terminal ANAPC4_WD40 PF12894.7 VDK78040.1 - 0.062 13.6 0.0 0.1 12.9 0.0 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Shugoshin_C PF07557.11 VDK78041.1 - 0.00026 20.7 1.9 0.00049 19.8 0.2 2.5 2 0 0 2 2 2 1 Shugoshin C terminus DivIC PF04977.15 VDK78041.1 - 0.0031 17.3 2.5 0.0031 17.3 2.5 1.8 2 0 0 2 2 2 1 Septum formation initiator dCache_2 PF08269.11 VDK78041.1 - 0.005 16.1 2.4 0.01 15.0 2.4 1.4 1 0 0 1 1 1 1 Cache domain HMMR_N PF15905.5 VDK78041.1 - 0.0071 15.9 1.2 0.0071 15.9 1.2 2.1 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal FlxA PF14282.6 VDK78041.1 - 0.021 14.8 1.9 0.063 13.3 1.9 1.8 1 0 0 1 1 1 0 FlxA-like protein LXG PF04740.12 VDK78041.1 - 0.28 10.9 5.2 0.24 11.1 3.4 1.7 2 0 0 2 2 2 0 LXG domain of WXG superfamily DUF3461 PF11944.8 VDK78041.1 - 0.97 9.6 5.0 20 5.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3461) TMF_TATA_bd PF12325.8 VDK78041.1 - 2.2 8.5 10.3 0.75 10.0 6.3 2.2 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding VPS53_C PF16854.5 VDK78041.1 - 7 6.5 8.2 1.2 9.0 0.2 2.5 3 0 0 3 3 3 0 Vacuolar protein sorting-associated protein 53 C-terminus DUF3453 PF11935.8 VDK78043.1 - 4.7e-55 186.7 1.5 1.3e-54 185.2 1.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) Symplekin_C PF12295.8 VDK78043.1 - 3.9e-38 131.4 1.2 2.5e-37 128.8 0.1 2.6 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal IZUMO PF15005.6 VDK78043.1 - 1.4 9.4 7.4 0.15 12.6 0.5 2.9 2 1 1 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated ANAPC4_WD40 PF12894.7 VDK78045.1 - 2.2e-08 34.3 0.1 2.3e-05 24.6 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK78045.1 - 4.5e-06 27.3 1.1 0.13 13.2 0.3 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat WDCP PF15390.6 VDK78045.1 - 0.14 10.5 0.3 0.21 9.9 0.3 1.2 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family An_peroxidase PF03098.15 VDK78046.1 - 4.7e-109 365.4 0.0 8.1e-109 364.6 0.0 1.3 1 0 0 1 1 1 1 Animal haem peroxidase I-set PF07679.16 VDK78046.1 - 1.5e-38 130.7 0.0 3.5e-19 68.7 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK78046.1 - 4.8e-34 116.8 0.0 1.2e-16 61.0 0.0 2.8 3 0 0 3 3 2 2 Immunoglobulin domain LRR_8 PF13855.6 VDK78046.1 - 2.9e-20 71.8 14.8 9e-12 44.6 3.3 2.7 1 1 1 2 2 2 2 Leucine rich repeat Ig_2 PF13895.6 VDK78046.1 - 8.2e-20 70.9 0.0 9e-09 35.6 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 VDK78046.1 - 1.6e-17 63.4 0.0 6.5e-08 32.6 0.0 2.6 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 VDK78046.1 - 3.2e-08 33.7 0.3 0.0042 17.2 0.0 3.7 2 2 0 2 2 2 2 Immunoglobulin V-set domain LRR_4 PF12799.7 VDK78046.1 - 6.1e-08 32.8 7.1 0.0024 18.3 1.2 2.7 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) C2-set_2 PF08205.12 VDK78046.1 - 3.2e-07 30.3 0.0 0.0089 16.1 0.0 2.5 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_C17orf99 PF17736.1 VDK78046.1 - 0.0011 18.9 0.0 2.5 8.2 0.0 2.4 2 0 0 2 2 2 2 C17orf99 Ig domain LRRNT PF01462.18 VDK78046.1 - 0.0036 16.9 3.8 0.0036 16.9 3.8 2.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain Ig_4 PF16680.5 VDK78046.1 - 0.0074 16.5 0.0 1.8 8.9 0.0 2.9 2 0 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 VDK78046.1 - 0.0083 16.5 0.0 1.7 9.1 0.0 2.7 2 0 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain LRR_9 PF14580.6 VDK78046.1 - 0.096 12.2 0.9 0.19 11.2 0.9 1.4 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 VDK78046.1 - 4 7.7 8.8 8.5 6.7 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat An_peroxidase PF03098.15 VDK78047.1 - 4.3e-40 137.8 0.0 5.2e-40 137.5 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase PLDc_3 PF13918.6 VDK78049.1 - 1.6e-32 112.6 0.1 2.6e-32 111.9 0.1 1.3 1 0 0 1 1 1 1 PLD-like domain PLDc_2 PF13091.6 VDK78049.1 - 3.9e-24 85.0 0.0 1.6e-13 50.7 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 VDK78049.1 - 3.4e-10 39.7 7.9 4.9e-08 32.8 1.2 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif DUF1194 PF06707.11 VDK78049.1 - 0.012 14.8 0.0 0.021 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1194) Cyclin_N PF00134.23 VDK78053.1 - 8.9e-06 25.5 0.2 3.1e-05 23.7 0.1 1.9 1 1 1 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 VDK78053.1 - 0.00055 20.3 0.1 0.00055 20.3 0.1 1.6 2 0 0 2 2 2 1 Cyclin FMO-like PF00743.19 VDK78054.1 - 3.3e-158 527.4 0.0 4e-158 527.1 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 VDK78054.1 - 1.2e-26 93.7 0.0 9.7e-24 84.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 VDK78054.1 - 7.8e-15 54.9 0.0 1e-13 51.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 VDK78054.1 - 4.8e-07 29.2 0.0 6.5e-06 25.5 0.0 2.4 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 VDK78054.1 - 5.3e-05 22.1 0.1 0.2 10.3 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 VDK78054.1 - 0.00018 21.7 0.2 0.00066 19.9 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 VDK78054.1 - 0.0035 17.3 1.6 0.28 11.2 0.1 3.7 4 1 0 4 4 4 1 FAD-NAD(P)-binding Thi4 PF01946.17 VDK78054.1 - 0.0096 15.2 0.2 3.5 6.8 0.1 2.3 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 VDK78054.1 - 0.014 15.0 0.1 1.1 8.8 0.0 3.0 3 0 0 3 3 3 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 VDK78054.1 - 0.015 15.8 0.4 1.9 9.1 0.1 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 VDK78054.1 - 0.043 13.2 0.1 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 VDK78054.1 - 0.13 11.6 0.1 0.27 10.5 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Cyclin_N PF00134.23 VDK78055.1 - 7.8e-19 67.7 0.1 1.9e-18 66.4 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 VDK78055.1 - 0.0023 18.0 0.1 0.026 14.6 0.1 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain DUF3400 PF11880.8 VDK78055.1 - 0.083 12.4 2.1 2.8 7.5 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3400) Cyclin_C_2 PF16899.5 VDK78055.1 - 0.12 12.8 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 Cyclin C-terminal domain FAM195 PF14799.6 VDK78056.1 - 0.0013 19.0 0.1 0.0025 18.1 0.0 1.7 1 1 0 1 1 1 1 FAM195 family DUF4502 PF14950.6 VDK78056.1 - 0.17 11.3 0.0 0.18 11.2 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4502) GAS PF13851.6 VDK78057.1 - 0.00059 19.2 21.5 0.00059 19.2 21.5 2.8 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 VDK78057.1 - 0.023 14.9 5.1 0.023 14.9 5.1 3.7 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding Kinesin_assoc PF16183.5 VDK78057.1 - 2.2 8.4 14.1 0.37 10.9 9.2 2.1 1 1 1 2 2 2 0 Kinesin-associated DUF4600 PF15372.6 VDK78057.1 - 4.4 7.7 26.2 0.072 13.5 14.6 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4600) DUF747 PF05346.11 VDK78059.1 - 4.7e-103 345.0 22.5 6e-103 344.7 22.5 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family Myotub-related PF06602.14 VDK78071.1 - 2e-109 365.8 0.1 2.7e-109 365.3 0.1 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.21 VDK78071.1 - 2.5e-18 66.0 10.1 8.1e-18 64.3 9.6 2.2 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 VDK78071.1 - 0.00067 19.9 5.0 0.00067 19.9 5.0 2.5 2 0 0 2 2 2 1 FYVE-type zinc finger Y_phosphatase3 PF13350.6 VDK78071.1 - 0.001 19.1 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 VDK78071.1 - 0.0019 18.0 0.0 0.0047 16.7 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Cas_APE2256 PF09651.10 VDK78071.1 - 0.04 13.8 0.0 0.095 12.6 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) Y_phosphatase PF00102.27 VDK78071.1 - 0.053 13.1 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase zf-C2HC5 PF06221.13 VDK78071.1 - 0.12 12.4 4.0 0.57 10.2 4.0 2.2 1 0 0 1 1 1 0 Putative zinc finger motif, C2HC5-type DUF1104 PF06518.11 VDK78071.1 - 0.26 11.7 0.7 3.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) IBR PF01485.21 VDK78071.1 - 0.44 10.8 8.3 0.34 11.2 5.2 2.4 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Pkinase PF00069.25 VDK78074.1 - 9.1e-18 64.6 1.3 1.2e-17 64.2 1.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78074.1 - 1.5e-10 40.9 1.1 1.8e-10 40.5 1.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC2_membrane PF01061.24 VDK78074.1 - 0.029 13.8 0.1 0.039 13.4 0.1 1.2 1 0 0 1 1 1 0 ABC-2 type transporter Kinase-like PF14531.6 VDK78074.1 - 0.054 12.8 0.4 0.13 11.5 0.1 1.7 1 1 1 2 2 2 0 Kinase-like Pkinase PF00069.25 VDK78075.1 - 2.7e-41 141.7 0.0 3.1e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78075.1 - 2.8e-17 62.9 0.0 3.6e-17 62.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK78075.1 - 0.00038 19.9 0.0 0.00055 19.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 VDK78075.1 - 0.03 14.2 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 VDK78075.1 - 0.09 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 VDK78075.1 - 0.17 10.8 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain tRNA-synt_1 PF00133.22 VDK78076.1 - 0.0065 14.8 0.3 0.0095 14.2 0.1 1.3 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) FA_hydroxylase PF04116.13 VDK78080.1 - 1.6e-09 38.2 7.2 1.6e-09 38.2 7.2 3.2 3 1 0 3 3 3 1 Fatty acid hydroxylase superfamily MCM PF00493.23 VDK78082.1 - 1.9e-95 318.2 0.1 3.2e-95 317.5 0.1 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 VDK78082.1 - 7.1e-39 132.5 2.2 1.4e-38 131.5 2.2 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 VDK78082.1 - 7.9e-28 96.7 2.4 1.4e-27 95.9 1.4 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 VDK78082.1 - 5.8e-14 52.5 0.0 1.3e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 VDK78082.1 - 1.4e-06 27.8 0.0 0.00063 19.2 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 VDK78082.1 - 7.6e-06 26.0 0.0 1.8e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 VDK78082.1 - 0.01 15.7 0.0 0.033 14.0 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 VDK78082.1 - 0.017 14.8 0.0 0.24 11.1 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain zf-U11-48K PF05253.12 VDK78082.1 - 0.41 10.6 2.6 3.3 7.7 0.4 2.9 2 0 0 2 2 2 0 U11-48K-like CHHC zinc finger RNA_pol PF00940.19 VDK78084.1 - 1.3e-139 465.6 0.0 2.2e-139 464.9 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 VDK78084.1 - 3.4e-13 49.7 0.1 2.3e-12 47.0 0.0 2.1 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal MOZ_SAS PF01853.18 VDK78087.1 - 1.4e-84 282.3 0.7 2.2e-84 281.6 0.7 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 VDK78087.1 - 1.5e-22 78.9 3.7 1.5e-22 78.9 3.7 2.4 3 0 0 3 3 3 1 MYST family zinc finger domain Tudor-knot PF11717.8 VDK78087.1 - 3.3e-19 68.5 0.1 3.1e-18 65.4 0.0 2.3 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 VDK78087.1 - 7.6e-05 23.1 0.0 0.00016 22.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 VDK78087.1 - 0.00016 21.9 0.0 0.0004 20.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family zf-BED PF02892.15 VDK78087.1 - 0.058 13.4 2.0 0.14 12.2 2.0 1.7 1 0 0 1 1 1 0 BED zinc finger DUF4554 PF15091.6 VDK78088.1 - 7.8 5.3 10.4 10 4.9 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) ALMT PF11744.8 VDK78088.1 - 8.2 5.1 11.6 8.7 5.0 11.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NMT_C PF02799.15 VDK78090.1 - 3.1e-75 252.3 0.2 3.7e-75 252.0 0.2 1.1 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 VDK78090.1 - 1.3e-27 96.6 0.7 2.9e-27 95.5 0.7 1.6 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_1 PF00583.25 VDK78090.1 - 0.17 12.2 0.0 0.68 10.2 0.0 2.0 2 1 0 2 2 2 0 Acetyltransferase (GNAT) family DAAD PF18752.1 VDK78106.1 - 0.43 10.4 7.1 0.34 10.7 5.7 1.4 1 1 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase eIF-3_zeta PF05091.12 VDK78107.1 - 2.9e-194 646.9 0.2 3.3e-194 646.7 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 VDK78107.1 - 0.0027 17.2 0.0 0.0076 15.8 0.0 1.7 1 1 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus Folliculin_C PF16692.5 VDK78108.1 - 3.7e-63 213.3 0.1 5.7e-63 212.7 0.1 1.3 1 0 0 1 1 1 1 Folliculin C-terminal domain Folliculin PF11704.8 VDK78108.1 - 1.1e-42 146.0 0.4 1.6e-42 145.5 0.4 1.3 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Ion_trans_2 PF07885.16 VDK78112.1 - 4.3e-32 109.9 20.1 7.8e-16 57.8 9.2 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK78112.1 - 4e-05 23.0 8.9 0.0028 16.9 0.0 2.7 3 0 0 3 3 3 2 Ion transport protein DUF733 PF05306.11 VDK78112.1 - 5.6 7.4 9.0 16 5.9 9.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF733) Surp PF01805.20 VDK78114.1 - 2.7e-41 139.3 3.8 1.2e-19 70.0 0.6 2.5 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 VDK78114.1 - 1.6e-39 136.0 8.0 2.9e-39 135.2 8.0 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein ubiquitin PF00240.23 VDK78114.1 - 1.2e-12 47.4 0.0 5.6e-12 45.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 VDK78114.1 - 0.0091 15.8 0.0 0.036 13.9 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Copine PF07002.16 VDK78115.1 - 4.7e-66 222.4 0.1 9.8e-66 221.3 0.1 1.6 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 VDK78115.1 - 7.2e-10 39.3 0.1 2.1e-09 37.8 0.1 1.8 1 0 0 1 1 1 1 vWA found in TerF C terminus Ribosomal_S22 PF08136.11 VDK78136.1 - 0.12 12.7 0.5 1.3 9.5 0.1 2.0 2 0 0 2 2 2 0 30S ribosomal protein subunit S22 family DUF4131 PF13567.6 VDK78136.1 - 2.5 7.7 11.2 12 5.5 11.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) F-box PF00646.33 VDK78137.1 - 1.3e-07 31.3 2.7 2.9e-05 23.8 0.5 3.3 2 0 0 2 2 2 2 F-box domain RRM_1 PF00076.22 VDK78137.1 - 1.9e-07 30.8 0.0 2.4e-05 24.1 0.0 3.3 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_6 PF13516.6 VDK78137.1 - 1.3e-05 24.9 6.7 2.7 8.3 0.0 6.9 6 0 0 6 6 6 1 Leucine Rich repeat LRR_4 PF12799.7 VDK78137.1 - 0.00031 21.1 14.3 1.9 9.0 0.0 6.1 3 2 2 5 5 5 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 VDK78137.1 - 0.0018 18.1 3.0 0.0024 17.7 0.1 2.8 3 0 0 3 3 3 1 F-box-like RRM_7 PF16367.5 VDK78137.1 - 0.029 14.5 0.0 0.071 13.2 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif GhoS PF11080.8 VDK78137.1 - 0.075 13.0 0.0 0.25 11.4 0.0 1.9 1 0 0 1 1 1 0 Endoribonuclease GhoS T4_Rnl2_C PF18043.1 VDK78137.1 - 0.11 12.6 1.5 0.3 11.2 0.0 2.4 3 0 0 3 3 3 0 T4 RNA ligase 2 C-terminal LRR_1 PF00560.33 VDK78137.1 - 0.71 10.6 0.0 0.71 10.6 0.0 7.7 8 2 0 8 8 8 0 Leucine Rich Repeat YhfH PF14149.6 VDK78138.1 - 0.0028 17.6 1.6 0.033 14.2 0.1 2.3 2 0 0 2 2 2 1 YhfH-like protein Stig1 PF04885.13 VDK78138.1 - 0.11 13.0 9.9 0.75 10.3 3.7 2.2 2 0 0 2 2 2 0 Stigma-specific protein, Stig1 DUF2367 PF10164.9 VDK78138.1 - 4 8.0 14.8 0.27 11.7 10.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) DNA_ligase_ZBD PF03119.16 VDK78138.1 - 4.3 7.5 11.5 12 6.0 1.1 2.7 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain RFX_DNA_binding PF02257.15 VDK78140.1 - 8.3e-34 116.1 0.0 1.9e-33 114.9 0.0 1.7 1 0 0 1 1 1 1 RFX DNA-binding domain Pkinase PF00069.25 VDK78141.1 - 1.2e-16 60.9 0.0 3.4e-14 52.8 0.0 2.6 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78141.1 - 0.00042 19.7 0.0 0.0039 16.5 0.0 2.6 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK78141.1 - 0.066 12.0 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PKD_channel PF08016.12 VDK78142.1 - 6.6e-11 41.5 16.3 1e-10 40.9 16.4 1.3 1 1 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 VDK78142.1 - 8.2e-05 21.9 29.8 0.00017 20.9 29.8 1.6 1 1 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 VDK78152.1 - 8.3e-21 74.1 0.0 1.7e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 VDK78152.1 - 0.0023 18.2 0.0 0.0053 17.0 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain RNase_PH PF01138.21 VDK78155.1 - 1.7e-06 28.5 2.0 7.4e-06 26.5 2.0 1.9 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 EF-hand_7 PF13499.6 VDK78157.1 - 7e-28 96.9 3.6 2.8e-13 50.1 0.0 3.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 VDK78157.1 - 1e-26 90.4 10.4 5.5e-06 25.6 0.0 5.4 5 1 0 5 5 5 5 EF hand EF-hand_8 PF13833.6 VDK78157.1 - 9.4e-24 83.0 2.9 5.9e-12 45.2 0.0 4.4 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 VDK78157.1 - 7.5e-22 75.4 4.6 6.6e-05 22.5 0.0 5.2 5 0 0 5 5 5 5 EF-hand domain EF-hand_5 PF13202.6 VDK78157.1 - 1.9e-18 65.0 7.3 0.00022 20.6 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 VDK78157.1 - 0.0047 17.2 0.1 6 7.3 0.0 3.0 2 1 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 VDK78157.1 - 0.092 13.1 0.6 0.89 9.9 0.1 2.5 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region GUN4 PF05419.12 VDK78157.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.6 2 0 0 2 2 2 0 GUN4-like Sec1 PF00995.23 VDK78158.1 - 1.1e-115 388.1 2.7 1.3e-115 387.9 2.7 1.0 1 0 0 1 1 1 1 Sec1 family GlutR_dimer PF00745.20 VDK78158.1 - 0.062 13.8 0.1 14 6.2 0.0 3.6 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain TFR_dimer PF04253.15 VDK78158.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 Transferrin receptor-like dimerisation domain Collagen PF01391.18 VDK78162.1 - 1.3e-23 82.5 99.4 1.5e-09 37.5 35.2 4.1 1 1 2 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK78162.1 - 2.5e-17 62.7 0.3 3.4e-17 62.2 0.3 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain NB-ARC PF00931.22 VDK78163.1 - 3.4e-12 46.1 0.0 5.2e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain CARD PF00619.21 VDK78163.1 - 0.00022 21.2 0.0 0.00044 20.2 0.0 1.5 1 0 0 1 1 1 1 Caspase recruitment domain Viral_helicase1 PF01443.18 VDK78163.1 - 0.0016 18.3 0.1 0.0043 16.8 0.0 1.8 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 VDK78163.1 - 0.0054 17.0 0.0 0.012 15.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK78163.1 - 0.02 15.3 0.0 0.048 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 VDK78163.1 - 0.07 13.5 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF4996 PF16387.5 VDK78163.1 - 0.094 13.2 0.0 0.27 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Motile_Sperm PF00635.26 VDK78163.1 - 0.11 12.4 0.0 0.88 9.4 0.0 2.2 2 0 0 2 2 2 0 MSP (Major sperm protein) domain AAA_33 PF13671.6 VDK78163.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Acetyltransf_13 PF13880.6 VDK78171.1 - 7.8e-21 73.8 0.3 2e-20 72.5 0.0 1.9 2 0 0 2 2 2 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 VDK78171.1 - 8.1e-15 54.4 6.9 1.8e-14 53.3 6.9 1.6 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 VDK78171.1 - 0.013 15.9 0.0 0.029 14.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 VDK78171.1 - 0.041 14.1 0.0 0.081 13.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Ribosomal_S24e PF01282.19 VDK78171.1 - 0.19 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S24e RRM_1 PF00076.22 VDK78172.1 - 1e-18 66.9 0.0 1.8e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 VDK78172.1 - 0.0043 17.0 0.0 0.0087 16.0 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 VDK78172.1 - 0.03 14.4 1.8 0.074 13.1 0.1 2.4 2 0 0 2 2 2 0 Limkain b1 DUF4187 PF13821.6 VDK78173.1 - 4.7e-18 64.7 4.5 1.2e-17 63.4 4.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 VDK78173.1 - 4.4e-11 42.5 0.2 9.6e-11 41.4 0.2 1.6 1 0 0 1 1 1 1 G-patch domain DUF5561 PF17716.1 VDK78173.1 - 0.019 14.3 0.1 0.046 13.0 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5561) G-patch_2 PF12656.7 VDK78173.1 - 0.029 14.5 0.1 0.11 12.6 0.1 2.0 1 0 0 1 1 1 0 G-patch domain CwfJ_C_1 PF04677.15 VDK78174.1 - 1.7e-36 124.8 0.1 2.8e-36 124.0 0.1 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 VDK78174.1 - 2.2e-13 50.9 0.0 1.3e-12 48.4 0.0 2.3 3 0 0 3 3 3 1 Protein similar to CwfJ C-terminus 2 Pkinase PF00069.25 VDK78177.1 - 1.3e-50 172.2 0.1 2.8e-32 112.1 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78177.1 - 3.5e-24 85.5 0.5 4.3e-15 55.7 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 VDK78177.1 - 0.00023 21.8 0.7 0.0012 19.5 0.1 2.5 2 0 0 2 2 2 1 Protein kinase C terminal domain Kdo PF06293.14 VDK78177.1 - 0.0091 15.4 0.1 0.042 13.2 0.0 2.0 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK78177.1 - 0.021 14.7 1.0 1 9.2 0.1 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 VDK78177.1 - 0.058 12.4 0.0 0.092 11.7 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Glyco_hydro_38N PF01074.22 VDK78178.1 - 2.3e-90 302.9 5.1 5.4e-90 301.7 5.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 VDK78178.1 - 9.1e-27 94.5 0.0 2.6e-26 93.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 VDK78178.1 - 8.5e-23 80.3 0.8 2.7e-22 78.7 0.1 2.3 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 VDK78178.1 - 0.006 16.7 0.0 0.019 15.1 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain EGF PF00008.27 VDK78192.1 - 0.0073 16.6 2.2 0.013 15.8 2.2 1.4 1 0 0 1 1 1 1 EGF-like domain MADF_DNA_bdg PF10545.9 VDK78195.1 - 1.9e-16 60.1 0.4 4.4e-16 59.0 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK78195.1 - 8.9e-10 38.8 0.6 8.9e-10 38.8 0.6 1.7 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain AAA_lid_6 PF17866.1 VDK78195.1 - 0.016 15.4 0.5 22 5.3 0.1 3.5 3 1 0 3 3 3 0 AAA lid domain MOR2-PAG1_N PF14222.6 VDK78196.1 - 5.1e-135 451.5 5.2 8.9e-135 450.7 5.2 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 VDK78196.1 - 1.2e-39 136.7 3.3 1.2e-39 136.7 3.3 3.8 5 0 0 5 5 5 1 Cell morphogenesis C-terminal T-box PF00907.22 VDK78198.1 - 4.5e-05 23.8 0.0 8.2e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 T-box T-box PF00907.22 VDK78200.1 - 1.1e-33 117.0 0.0 1.4e-33 116.7 0.0 1.0 1 0 0 1 1 1 1 T-box PP2C_2 PF13672.6 VDK78206.1 - 1.9e-08 34.2 0.1 3.8e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 VDK78206.1 - 0.0006 19.8 0.0 0.0013 18.7 0.0 1.5 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) DUF4071 PF13281.6 VDK78207.1 - 1.1e-125 419.6 5.9 2.7e-124 415.0 5.9 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4071) Pkinase PF00069.25 VDK78207.1 - 4.2e-56 190.2 0.0 9.1e-56 189.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78207.1 - 8.6e-41 139.9 0.0 2.1e-40 138.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK78207.1 - 0.0016 17.3 0.0 0.022 13.5 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase DRMBL PF07522.14 VDK78208.1 - 0.0018 18.4 0.2 0.0058 16.8 0.1 1.9 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase ICA69 PF04629.14 VDK78208.1 - 0.14 12.5 1.9 0.2 11.9 1.9 1.2 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain Tetraspanin PF00335.20 VDK78209.1 - 7.8e-06 25.8 0.2 1.6e-05 24.7 0.2 1.5 1 1 0 1 1 1 1 Tetraspanin family DUF3112 PF11309.8 VDK78209.1 - 0.083 12.3 0.3 0.11 11.9 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) Motile_Sperm PF00635.26 VDK78210.1 - 9.2e-08 31.9 0.0 1.6e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain PRP38 PF03371.15 VDK78211.1 - 4.8e-60 202.4 1.5 6e-60 202.1 1.5 1.1 1 0 0 1 1 1 1 PRP38 family DUF4228 PF14009.6 VDK78211.1 - 0.0088 16.5 1.3 0.012 16.0 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4228) CDC45 PF02724.14 VDK78211.1 - 9.5 4.4 15.8 11 4.2 15.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF727 PF05303.12 VDK78212.1 - 1.8e-34 117.9 0.0 2.4e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Gram_pos_anchor PF00746.21 VDK78213.1 - 1.5 8.8 8.4 1.9 8.5 2.4 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif SH2 PF00017.24 VDK78214.1 - 2.3e-11 43.6 0.0 5e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 SH2 domain PID PF00640.23 VDK78214.1 - 1.9e-05 24.8 0.1 4e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF3480 PF11979.8 VDK78215.1 - 1.3e-63 215.1 0.0 1.8e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3480) FYVE PF01363.21 VDK78215.1 - 8.3e-18 64.3 13.3 1.8e-17 63.2 13.3 1.6 1 0 0 1 1 1 1 FYVE zinc finger TRAPPC9-Trs120 PF08626.11 VDK78216.1 - 0.034 11.5 0.2 0.041 11.3 0.2 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Proteasome PF00227.26 VDK78230.1 - 1e-39 136.0 0.3 1.4e-39 135.6 0.3 1.2 1 0 0 1 1 1 1 Proteasome subunit DUF4071 PF13281.6 VDK78232.1 - 0.0041 16.2 3.5 0.0075 15.4 3.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4071) DUF4363 PF14276.6 VDK78232.1 - 1.7 8.8 7.3 0.42 10.7 0.6 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4363) Fibrillarin PF01269.17 VDK78233.1 - 5.3e-107 356.1 0.0 6.4e-107 355.8 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 VDK78233.1 - 0.0006 19.6 0.0 0.00097 18.9 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 VDK78233.1 - 0.092 12.5 0.0 0.21 11.3 0.0 1.6 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 7tm_1 PF00001.21 VDK78234.1 - 6.1e-27 94.6 5.8 7.8e-27 94.2 5.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK78234.1 - 0.00011 21.7 2.5 0.00016 21.2 2.5 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 VDK78235.1 - 0.019 14.3 0.0 0.019 14.3 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) IF2_N PF04760.15 VDK78237.1 - 0.08 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Rad1 PF02144.16 VDK78241.1 - 2.8e-41 141.4 0.0 7.2e-41 140.1 0.0 1.5 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 TFIIF_alpha PF05793.12 VDK78241.1 - 6e-40 137.3 39.1 4.6e-38 131.1 39.1 2.1 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SNF PF00209.18 VDK78244.1 - 4.1e-10 39.0 5.8 4.7e-10 38.8 5.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Ig_3 PF13927.6 VDK78253.1 - 2.5e-60 201.0 0.0 4.1e-12 46.5 0.0 6.9 6 0 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 VDK78253.1 - 4.3e-59 196.6 0.0 2e-11 43.8 0.0 6.7 6 0 0 6 6 6 6 Immunoglobulin I-set domain fn3 PF00041.21 VDK78253.1 - 7.2e-42 141.6 7.3 2.2e-10 40.7 0.4 5.5 5 0 0 5 5 5 5 Fibronectin type III domain Ig_2 PF13895.6 VDK78253.1 - 2.9e-38 130.0 0.0 1.9e-07 31.3 0.0 6.5 6 0 0 6 6 6 6 Immunoglobulin domain ig PF00047.25 VDK78253.1 - 2.7e-32 110.8 0.0 6e-09 36.0 0.0 7.4 7 1 0 7 7 7 5 Immunoglobulin domain V-set PF07686.17 VDK78253.1 - 1.3e-20 73.6 2.5 0.0021 18.2 0.0 8.7 6 4 0 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK78253.1 - 9.7e-05 22.4 0.0 6.1 7.0 0.0 3.8 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 VDK78253.1 - 0.0001 21.8 0.1 3.5 7.3 0.0 4.3 5 0 0 5 5 5 2 Immunoglobulin domain Ig_4 PF16680.5 VDK78253.1 - 0.00012 22.3 0.0 0.4 11.0 0.0 4.3 5 0 0 5 5 5 1 T-cell surface glycoprotein CD3 delta chain Ig_C17orf99 PF17736.1 VDK78253.1 - 0.00031 20.7 0.1 4.8 7.3 0.0 4.7 4 1 0 4 4 4 1 C17orf99 Ig domain Izumo-Ig PF16706.5 VDK78253.1 - 0.0036 17.3 0.0 2 8.5 0.0 3.4 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Plexin_cytopl PF08337.12 VDK78254.1 - 6e-79 266.2 3.5 4.4e-49 167.6 0.0 2.1 1 1 1 2 2 2 2 Plexin cytoplasmic RasGAP domain TIG PF01833.24 VDK78254.1 - 1.1e-14 54.2 0.7 5.6e-08 32.7 0.1 3.6 3 0 0 3 3 3 2 IPT/TIG domain Chordopox_A13L PF05961.11 VDK78254.1 - 0.082 13.2 0.9 0.38 11.0 0.1 2.3 2 0 0 2 2 2 0 Chordopoxvirus A13L protein UPRTase PF14681.6 VDK78255.1 - 2.2e-68 229.8 0.1 3.4e-68 229.2 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRK PF00485.18 VDK78255.1 - 6.2e-60 202.3 0.0 9.3e-60 201.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 VDK78255.1 - 3.7e-09 37.2 0.0 7.5e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 VDK78255.1 - 2.1e-05 24.4 0.0 5.2e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 VDK78255.1 - 0.00013 22.2 0.0 0.00032 20.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 VDK78255.1 - 0.0002 21.8 0.8 0.0044 17.4 0.4 2.8 2 1 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 VDK78255.1 - 0.00035 20.4 0.0 0.092 12.5 0.0 2.3 2 0 0 2 2 2 2 Cytidylate kinase CoaE PF01121.20 VDK78255.1 - 0.00053 19.7 0.0 0.055 13.2 0.0 2.3 2 0 0 2 2 2 1 Dephospho-CoA kinase Parvo_NS1 PF01057.17 VDK78255.1 - 0.021 13.9 0.1 0.074 12.1 0.0 1.9 3 0 0 3 3 3 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 VDK78255.1 - 0.041 13.2 0.0 0.09 12.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 VDK78255.1 - 0.1 12.8 0.1 0.24 11.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF2616 PF11077.8 VDK78255.1 - 0.22 11.2 0.0 0.38 10.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) Cast PF10174.9 VDK78256.1 - 4.2e-45 154.3 97.1 7.1e-18 64.2 50.5 3.6 1 1 2 3 3 3 3 RIM-binding protein of the cytomatrix active zone DUF2570 PF10828.8 VDK78256.1 - 0.0082 16.0 3.0 0.0082 16.0 3.0 6.5 3 2 4 7 7 7 1 Protein of unknown function (DUF2570) WD40_alt PF14077.6 VDK78256.1 - 0.017 15.0 2.7 42 4.1 0.0 4.3 3 0 0 3 3 3 0 Alternative WD40 repeat motif EMC1_C PF07774.13 VDK78256.1 - 0.024 14.3 0.5 0.024 14.3 0.5 2.3 3 0 0 3 3 3 0 ER membrane protein complex subunit 1, C-terminal Endotoxin_N PF03945.14 VDK78256.1 - 0.11 12.2 2.4 0.33 10.6 0.2 2.5 2 0 0 2 2 2 0 delta endotoxin, N-terminal domain Stork_head PF10264.9 VDK78257.1 - 1.2e-14 54.2 0.1 3e-14 52.9 0.1 1.7 1 0 0 1 1 1 1 Winged helix Storkhead-box1 domain DUF4005 PF13178.6 VDK78257.1 - 0.035 14.8 0.3 0.063 13.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4005) IPK PF03770.16 VDK78258.1 - 4.1e-41 141.0 0.0 5.6e-41 140.6 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase Pkinase PF00069.25 VDK78259.1 - 9e-68 228.5 0.0 1.2e-67 228.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78259.1 - 2.9e-30 105.4 0.0 4.4e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK78259.1 - 1.2e-06 28.1 0.0 3.7e-06 26.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 VDK78259.1 - 0.00023 20.6 0.1 0.00039 19.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 VDK78259.1 - 0.042 13.5 0.1 2.8 7.5 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 VDK78259.1 - 0.065 13.2 0.0 4.6 7.1 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Sec23_trunk PF04811.15 VDK78260.1 - 3.3e-76 256.1 0.0 4.8e-76 255.5 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 VDK78260.1 - 2.5e-22 78.7 0.1 4.8e-22 77.7 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 VDK78260.1 - 7e-15 54.8 2.0 1.6e-14 53.7 2.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 VDK78260.1 - 1.1e-14 54.9 0.0 2.7e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 VDK78260.1 - 1.3e-06 28.2 0.0 3.6e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Yippee-Mis18 PF03226.14 VDK78276.1 - 5.3e-05 23.4 0.0 8.4e-05 22.7 0.0 1.3 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_2 PF13240.6 VDK78276.1 - 0.014 15.1 1.8 2.4 8.0 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 VDK78276.1 - 0.033 14.2 2.1 0.2 11.7 0.8 2.1 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 VDK78276.1 - 0.065 12.7 4.2 2.6 7.6 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain NADH_oxidored PF08040.11 VDK78276.1 - 0.11 12.2 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 MNLL subunit zinc_ribbon_4 PF13717.6 VDK78276.1 - 0.3 11.0 3.2 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn_ribbon_17 PF17120.5 VDK78276.1 - 0.49 10.1 4.5 3.3 7.4 0.1 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF1610 PF07754.11 VDK78276.1 - 0.76 9.8 6.3 0.96 9.5 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) EGF PF00008.27 VDK78277.1 - 3e-75 248.0 361.2 2.5e-07 30.9 4.0 28.3 27 1 0 27 27 27 20 EGF-like domain hEGF PF12661.7 VDK78277.1 - 2.9e-34 116.5 320.0 0.00052 20.6 6.2 28.8 28 1 0 28 28 28 20 Human growth factor-like EGF Laminin_G_2 PF02210.24 VDK78277.1 - 6.3e-23 81.7 6.1 1e-10 42.2 0.2 3.8 3 1 0 3 3 3 3 Laminin G domain Laminin_G_1 PF00054.23 VDK78277.1 - 3.9e-15 56.2 4.1 1e-08 35.5 0.0 5.7 4 2 0 4 4 4 3 Laminin G domain EGF_CA PF07645.15 VDK78277.1 - 3.3e-11 43.2 43.7 5e-07 29.8 7.2 26.5 12 7 14 26 26 26 8 Calcium-binding EGF domain EGF_2 PF07974.13 VDK78277.1 - 1e-06 29.0 401.1 0.0073 16.6 5.7 27.8 23 5 3 26 26 26 20 EGF-like domain EGF_3 PF12947.7 VDK78277.1 - 3.4e-05 23.9 14.8 0.0003 20.9 4.4 27.0 25 2 1 26 26 26 13 EGF domain 14-3-3 PF00244.20 VDK78279.1 - 1.4e-38 132.7 2.0 2.1e-38 132.0 2.0 1.3 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 VDK78279.1 - 0.0045 17.2 0.1 0.044 14.1 0.1 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TSNAXIP1_N PF15739.5 VDK78279.1 - 0.027 14.9 0.3 0.1 13.0 0.3 2.0 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus GRIP PF01465.20 VDK78280.1 - 1.2e-12 47.5 0.0 5.4e-12 45.4 0.0 2.2 2 0 0 2 2 2 1 GRIP domain Golgin_A5 PF09787.9 VDK78280.1 - 0.0025 17.3 16.3 0.0025 17.3 16.3 4.3 2 1 1 4 4 4 1 Golgin subfamily A member 5 SlyX PF04102.12 VDK78280.1 - 0.031 14.9 2.0 0.031 14.9 2.0 8.6 6 3 1 9 9 9 0 SlyX POTRA_2 PF08479.11 VDK78280.1 - 0.12 12.2 1.2 0.64 9.9 0.1 2.9 2 0 0 2 2 2 0 POTRA domain, ShlB-type SAB PF04382.13 VDK78280.1 - 1.4 9.1 6.4 1.6 8.9 1.1 3.3 2 0 0 2 2 2 0 SAB domain APC1_C PF18122.1 VDK78280.1 - 8.2 6.3 9.9 3.2 7.7 0.3 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex sub unit 1 C-terminal domain Rab5ip PF07019.12 VDK78281.1 - 5.7e-16 58.9 10.8 7.1e-16 58.6 10.8 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF3402 PF11882.8 VDK78284.1 - 0.0047 16.1 0.4 0.0085 15.2 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) Glyco_trans_2_3 PF13632.6 VDK78299.1 - 1.5e-38 132.7 2.0 1.5e-38 132.7 2.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 VDK78299.1 - 4.8e-07 29.9 0.0 6.9e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 DUF572 PF04502.13 VDK78300.1 - 6.1e-44 151.0 26.5 8e-24 84.9 13.6 2.0 2 0 0 2 2 2 2 Family of unknown function (DUF572) MCR PF18509.1 VDK78300.1 - 0.19 11.3 0.4 0.36 10.4 0.4 1.5 1 0 0 1 1 1 0 Magnetochrome domain DUF3655 PF12379.8 VDK78300.1 - 1 9.7 4.8 0.37 11.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3655) MMtag PF10159.9 VDK78300.1 - 3.4 8.0 5.6 3.5 8.0 1.4 2.5 1 1 1 2 2 2 0 Multiple myeloma tumor-associated TPR_1 PF00515.28 VDK78301.1 - 1e-20 72.6 24.2 0.00013 21.7 0.0 8.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 VDK78301.1 - 4.6e-18 63.8 25.3 0.0048 16.9 0.0 9.2 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_8 PF13181.6 VDK78301.1 - 1.2e-17 62.5 20.7 0.055 13.7 0.0 9.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 VDK78301.1 - 4.9e-14 52.4 7.3 0.00014 22.0 0.1 6.3 3 1 2 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 VDK78301.1 - 3.7e-12 46.0 1.0 0.0022 18.7 0.0 7.4 5 2 2 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK78301.1 - 6.7e-10 38.5 11.1 0.0006 19.5 0.3 4.8 5 1 1 6 6 6 3 TPR repeat TPR_7 PF13176.6 VDK78301.1 - 1.2e-09 37.5 4.5 0.2 11.8 0.2 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 VDK78301.1 - 2.3e-09 37.8 8.3 0.007 17.0 0.0 5.2 5 1 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK78301.1 - 1.2e-08 35.4 8.5 0.41 11.2 0.0 7.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK78301.1 - 9.2e-08 32.0 15.5 0.1 13.0 0.1 7.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_10 PF13374.6 VDK78301.1 - 4e-07 29.7 2.5 2.2 8.3 0.0 6.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 VDK78301.1 - 3e-05 23.4 4.9 0.029 13.6 0.2 4.0 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 VDK78301.1 - 0.00031 21.2 9.4 0.95 10.2 0.3 6.8 8 0 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK78301.1 - 0.0062 16.7 22.8 3.2 8.0 0.3 6.5 3 1 2 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 ANAPC8 PF04049.13 VDK78301.1 - 0.0072 16.4 7.0 0.0072 16.4 7.0 2.7 3 1 0 3 3 3 1 Anaphase promoting complex subunit 8 / Cdc23 ChAPs PF09295.10 VDK78301.1 - 0.02 13.9 0.0 3.1 6.7 0.0 2.8 1 1 3 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.9 VDK78301.1 - 0.067 12.9 0.9 1.8 8.2 0.0 3.1 3 1 0 3 3 3 0 26S proteasome subunit RPN7 Glyco_transf_7N PF13733.6 VDK78302.1 - 7.8e-23 80.6 0.2 1.3e-22 79.9 0.2 1.3 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 VDK78302.1 - 2.4e-22 78.4 0.0 5.2e-22 77.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase F-box PF00646.33 VDK78303.1 - 4.7e-08 32.7 0.8 1.4e-07 31.2 0.8 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 VDK78303.1 - 0.0007 19.4 1.9 0.0025 17.7 0.7 2.4 2 0 0 2 2 2 1 F-box-like ATP-synt_C PF00137.21 VDK78304.1 - 7.4e-31 106.3 35.8 5e-19 68.4 14.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C OppC_N PF12911.7 VDK78304.1 - 7.1 6.7 6.1 33 4.5 0.3 2.7 2 1 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C ATP-synt_C PF00137.21 VDK78305.1 - 1.4e-34 118.2 34.7 2.7e-22 78.9 13.7 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.8 VDK78305.1 - 1.6 8.7 7.7 0.46 10.4 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) zf-RING_2 PF13639.6 VDK78309.1 - 0.072 13.4 0.1 0.17 12.3 0.1 1.7 1 0 0 1 1 1 0 Ring finger domain CHGN PF05679.16 VDK78310.1 - 4.9e-111 372.1 0.0 6.4e-111 371.7 0.0 1.1 1 0 0 1 1 1 1 Chondroitin N-acetylgalactosaminyltransferase Fringe PF02434.16 VDK78310.1 - 0.046 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Fringe-like GTP_EFTU PF00009.27 VDK78312.1 - 3.2e-51 173.6 0.4 5.4e-51 172.9 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 VDK78312.1 - 2e-38 131.7 10.4 4.1e-38 130.7 10.4 1.6 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_C PF00679.24 VDK78312.1 - 1e-23 83.2 0.0 3.2e-23 81.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus EFG_IV PF03764.18 VDK78312.1 - 4.6e-22 78.1 0.0 9.7e-22 77.0 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 VDK78312.1 - 8.8e-12 45.2 0.0 1.7e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 VDK78312.1 - 2.4e-06 27.5 0.1 1.1e-05 25.4 0.1 2.2 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 VDK78312.1 - 4.2e-06 26.8 0.0 8.1e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 VDK78312.1 - 0.00029 21.0 0.0 0.002 18.3 0.0 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 VDK78312.1 - 0.00031 20.1 0.1 0.00053 19.3 0.1 1.3 1 0 0 1 1 1 1 Septin Dynamin_N PF00350.23 VDK78312.1 - 0.016 15.3 0.0 3.8 7.5 0.0 2.7 1 1 1 2 2 2 0 Dynamin family Ras PF00071.22 VDK78312.1 - 0.024 14.2 0.1 0.083 12.5 0.1 1.8 1 1 0 1 1 1 0 Ras family TniB PF05621.11 VDK78312.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein MFS_1 PF07690.16 VDK78313.1 - 7.2e-43 146.8 37.4 1.7e-41 142.3 34.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SDF PF00375.18 VDK78323.1 - 2.3e-131 438.4 38.7 2.7e-131 438.2 38.7 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Collagen PF01391.18 VDK78324.1 - 2.4e-24 84.8 77.8 5.9e-10 38.8 27.1 4.1 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK78324.1 - 4.8e-16 58.6 0.4 7e-16 58.0 0.4 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Collagen PF01391.18 VDK78326.1 - 2.6e-22 78.3 82.0 1.3e-08 34.4 29.5 3.9 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK78326.1 - 5.3e-17 61.6 0.4 7.2e-17 61.2 0.4 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain MDD_C PF18376.1 VDK78328.1 - 2.3e-63 213.4 0.1 3.2e-63 212.9 0.1 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 VDK78328.1 - 4.2e-05 23.7 0.7 0.00016 21.8 0.7 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain Glyco_transf_43 PF03360.16 VDK78329.1 - 9.8e-65 218.2 0.2 2.4e-64 217.0 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 43 DnaJ PF00226.31 VDK78329.1 - 4.2e-17 62.0 4.1 5.5e-17 61.7 2.0 2.4 2 0 0 2 2 2 1 DnaJ domain Ntox1 PF15500.6 VDK78329.1 - 0.063 13.6 0.5 0.16 12.3 0.5 1.7 1 0 0 1 1 1 0 Putative RNase-like toxin, toxin_1 DUF572 PF04502.13 VDK78330.1 - 4.2e-68 230.4 8.4 6.2e-68 229.9 8.4 1.2 1 1 0 1 1 1 1 Family of unknown function (DUF572) DUF951 PF06107.11 VDK78330.1 - 0.3 11.0 1.4 4.1 7.4 0.2 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) ZZ PF00569.17 VDK78330.1 - 4.5 7.2 7.6 14 5.6 0.2 3.4 4 0 0 4 4 4 0 Zinc finger, ZZ type LisH PF08513.11 VDK78331.1 - 0.021 14.8 0.1 0.038 13.9 0.1 1.4 1 0 0 1 1 1 0 LisH ATP-synt_DE_N PF02823.16 VDK78332.1 - 9.1e-16 57.5 0.0 1.3e-15 57.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain DUF4175 PF13779.6 VDK78332.1 - 0.0026 15.7 2.1 0.0032 15.5 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) ATP-synt_DE PF00401.20 VDK78332.1 - 0.0096 16.2 7.1 0.018 15.3 7.1 1.4 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, long alpha-helix domain SH3_9 PF14604.6 VDK78333.1 - 0.00017 21.4 0.0 0.00031 20.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK78333.1 - 0.00047 19.8 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PriC PF07445.12 VDK78333.1 - 0.0018 18.2 3.9 0.0038 17.2 3.9 1.5 1 0 0 1 1 1 1 Primosomal replication protein priC SH3_1 PF00018.28 VDK78333.1 - 0.0097 15.5 0.1 0.02 14.5 0.1 1.5 1 0 0 1 1 1 1 SH3 domain IL3 PF02059.15 VDK78333.1 - 0.28 11.3 4.5 0.87 9.7 4.5 1.9 1 0 0 1 1 1 0 Interleukin-3 V_ATPase_I PF01496.19 VDK78333.1 - 3.3 5.5 6.7 5.6 4.7 6.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MIP PF00230.20 VDK78336.1 - 5.1e-41 140.9 7.5 6.5e-41 140.5 7.5 1.0 1 0 0 1 1 1 1 Major intrinsic protein AcetylCoA_hyd_C PF13336.6 VDK78337.1 - 1e-57 194.4 0.0 2e-57 193.4 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 VDK78337.1 - 2.4e-17 63.6 0.0 5.3e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain I-set PF07679.16 VDK78338.1 - 1.5e-12 47.4 0.0 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK78338.1 - 7.4e-10 39.3 0.0 1.1e-09 38.8 0.0 1.2 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 VDK78338.1 - 0.00015 21.9 0.1 0.0002 21.5 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 VDK78338.1 - 0.00016 21.9 0.1 0.00022 21.5 0.1 1.2 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 VDK78338.1 - 0.00074 19.7 0.1 0.029 14.5 0.1 2.1 1 1 0 1 1 1 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK78338.1 - 0.003 17.6 0.0 0.0036 17.3 0.0 1.4 1 1 0 1 1 1 1 CD80-like C2-set immunoglobulin domain zf-C4 PF00105.18 VDK78347.1 - 2.2e-26 92.1 14.9 4.9e-26 91.0 14.9 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK78347.1 - 2.6e-22 79.5 0.0 4.5e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Ion_trans PF00520.31 VDK78349.1 - 8.6e-109 362.5 27.0 1.1e-64 218.1 8.3 3.4 3 1 0 3 3 3 3 Ion transport protein DUF2207 PF09972.9 VDK78349.1 - 0.32 9.7 2.0 0.87 8.3 1.9 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PKD_channel PF08016.12 VDK78349.1 - 1.7 7.2 22.2 0.28 9.8 0.1 5.0 4 1 1 5 5 5 0 Polycystin cation channel FAM176 PF14851.6 VDK78349.1 - 5.5 6.6 9.4 0.61 9.8 1.1 2.7 2 0 0 2 2 2 0 FAM176 family Ion_trans PF00520.31 VDK78351.1 - 2.6e-52 177.5 23.8 6.4e-29 100.9 9.4 3.1 2 1 1 3 3 3 3 Ion transport protein GPHH PF16905.5 VDK78351.1 - 1.3e-29 101.7 0.2 2.5e-29 100.8 0.2 1.5 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Ca_chan_IQ PF08763.11 VDK78351.1 - 1.7e-28 98.6 0.2 4e-28 97.4 0.2 1.7 1 0 0 1 1 1 1 Voltage gated calcium channel IQ domain PKD_channel PF08016.12 VDK78351.1 - 0.00041 19.1 1.4 0.00041 19.1 1.4 3.2 3 0 0 3 3 3 2 Polycystin cation channel E7 PF00527.18 VDK78353.1 - 0.09 13.0 2.9 0.15 12.2 2.9 1.5 1 1 0 1 1 1 0 E7 protein, Early protein ADK_lid PF05191.14 VDK78353.1 - 0.094 12.7 0.4 0.47 10.5 0.1 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf-C2H2_4 PF13894.6 VDK78353.1 - 0.12 13.3 0.7 0.23 12.4 0.7 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met PF12874.7 VDK78353.1 - 0.14 12.6 0.2 0.26 11.7 0.2 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 VDK78353.1 - 0.18 12.4 0.9 0.36 11.4 0.9 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type Pkinase PF00069.25 VDK78362.1 - 1.5e-57 195.0 0.0 2.7e-57 194.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78362.1 - 3.1e-26 92.2 0.0 9.4e-26 90.6 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 VDK78362.1 - 5.9e-06 25.8 0.0 1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK78362.1 - 2.2e-05 23.9 0.0 3.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 VDK78362.1 - 0.0015 18.1 0.1 0.0033 17.0 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 VDK78362.1 - 0.0028 16.5 0.0 0.0046 15.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK78362.1 - 0.037 13.9 0.0 0.074 13.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 VDK78362.1 - 0.13 11.9 0.1 0.24 11.0 0.1 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 LIM PF00412.22 VDK78363.1 - 1.1e-16 60.7 31.2 9.1e-10 38.6 10.5 3.1 2 1 2 4 4 4 2 LIM domain Phage_cap_P2 PF05125.12 VDK78363.1 - 0.16 11.0 1.0 0.21 10.6 1.0 1.1 1 0 0 1 1 1 0 Phage major capsid protein, P2 family Rtf2 PF04641.12 VDK78363.1 - 0.36 10.1 6.8 0.61 9.4 6.8 1.6 1 1 0 1 1 1 0 Rtf2 RING-finger ShK PF01549.24 VDK78364.1 - 1.9e-09 37.9 101.6 0.019 15.5 11.5 6.5 6 0 0 6 6 6 6 ShK domain-like YadA_head PF05658.14 VDK78364.1 - 0.02 15.3 0.4 0.02 15.3 0.4 2.2 2 0 0 2 2 2 0 Head domain of trimeric autotransporter adhesin RPAP1_N PF08621.10 VDK78366.1 - 7.8e-17 60.8 3.8 2e-16 59.5 3.8 1.8 1 0 0 1 1 1 1 RPAP1-like, N-terminal Ribosomal_S13 PF00416.22 VDK78366.1 - 0.68 10.3 3.1 0.78 10.1 1.4 2.0 2 0 0 2 2 2 0 Ribosomal protein S13/S18 CCDC24 PF15669.5 VDK78367.1 - 0.0012 18.7 0.4 0.0013 18.6 0.3 1.3 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 24 family IPP-2 PF04979.14 VDK78367.1 - 0.0013 19.5 18.7 0.15 12.8 18.7 3.0 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DUF5337 PF17272.2 VDK78367.1 - 0.014 15.2 0.3 0.025 14.4 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5337) Claudin_2 PF13903.6 VDK78367.1 - 0.019 14.7 1.7 0.019 14.7 1.7 1.7 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Med11 PF10280.9 VDK78367.1 - 0.02 15.4 1.9 0.027 14.9 1.9 1.2 1 0 0 1 1 1 0 Mediator complex protein PspB PF06667.12 VDK78367.1 - 0.024 14.7 0.1 3.1 7.9 0.0 2.5 2 0 0 2 2 2 0 Phage shock protein B Mlf1IP PF10248.9 VDK78367.1 - 0.028 14.4 9.2 0.041 13.9 9.2 1.2 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein MscS_TM PF12794.7 VDK78367.1 - 0.077 11.8 0.6 0.16 10.8 0.6 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 EssA PF10661.9 VDK78367.1 - 0.26 11.1 10.1 5.3 6.9 6.1 2.1 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA DUF2464 PF10240.9 VDK78369.1 - 1.4e-67 228.0 0.0 1.6e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 Multivesicular body subunit 12 OATP PF03137.20 VDK78373.1 - 4.7e-143 477.4 17.4 6.2e-143 477.0 17.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 VDK78373.1 - 1.3e-13 50.6 17.3 1.3e-13 50.6 17.3 3.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Kazal_2 PF07648.15 VDK78373.1 - 0.045 13.9 10.9 0.11 12.6 10.9 1.7 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain zf-C4 PF00105.18 VDK78375.1 - 5.9e-06 26.7 1.3 9.9e-06 25.9 1.3 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Y_phosphatase PF00102.27 VDK78378.1 - 8.4e-46 156.4 0.5 1.1e-45 156.0 0.5 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK78378.1 - 0.0022 17.8 0.1 0.0053 16.6 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK78378.1 - 0.0066 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Elf1 PF05129.13 VDK78394.1 - 3e-30 104.1 2.3 3.5e-30 103.9 2.3 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like hDGE_amylase PF14701.6 VDK78396.1 - 3.1e-140 468.1 0.6 5.4e-140 467.4 0.6 1.4 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 VDK78396.1 - 1.6e-119 399.2 0.2 2.4e-119 398.7 0.2 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 VDK78396.1 - 9.7e-50 169.6 4.1 7.5e-47 160.1 4.1 2.3 1 1 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 VDK78396.1 - 6.4e-06 26.2 0.0 6.9e-05 22.9 0.0 2.4 1 1 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme eIF3g PF12353.8 VDK78397.1 - 6.4e-31 107.3 1.9 1e-30 106.7 1.9 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 VDK78397.1 - 1.3e-19 69.7 0.1 2.6e-19 68.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 VDK78397.1 - 0.032 14.5 0.5 0.32 11.2 0.2 2.4 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 VDK78397.1 - 0.047 13.3 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 VDK78397.1 - 0.39 10.9 2.4 0.89 9.7 2.4 1.6 1 0 0 1 1 1 0 Zinc knuckle Arf PF00025.21 VDK78398.1 - 4.6e-71 237.9 0.3 5.1e-71 237.7 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 VDK78398.1 - 1.3e-12 47.6 1.8 4.7e-08 32.6 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 VDK78398.1 - 6.8e-12 45.3 0.0 7.9e-12 45.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK78398.1 - 9.8e-12 45.1 0.0 1.4e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 VDK78398.1 - 6.7e-10 38.7 0.0 9e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 VDK78398.1 - 4.6e-08 32.7 0.0 5.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK78398.1 - 2.1e-06 27.8 0.0 3e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 VDK78398.1 - 0.002 17.7 0.0 0.0094 15.5 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 VDK78398.1 - 0.0036 16.9 0.1 0.023 14.3 0.0 1.9 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 VDK78398.1 - 0.013 15.0 0.1 0.032 13.8 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_18 PF13238.6 VDK78398.1 - 0.068 13.7 0.1 0.11 13.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 VDK78398.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation N_BRCA1_IG PF16158.5 VDK78400.1 - 0.0026 18.4 0.1 0.0051 17.5 0.1 1.5 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PAS_11 PF14598.6 VDK78401.1 - 4.1e-17 62.3 0.2 7.8e-10 38.9 0.1 2.4 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 VDK78401.1 - 1e-13 51.4 0.0 3.2e-09 36.9 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 VDK78401.1 - 6.4e-13 48.7 0.0 5.8e-10 39.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_2 PF08446.11 VDK78401.1 - 9.1e-05 23.1 0.1 0.11 13.2 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 VDK78401.1 - 0.00041 20.6 0.0 0.018 15.3 0.0 2.5 2 1 0 2 2 2 1 PAS domain PAS_4 PF08448.10 VDK78401.1 - 0.00084 19.6 0.0 0.042 14.1 0.0 2.2 2 0 0 2 2 2 1 PAS fold HLH PF00010.26 VDK78401.1 - 0.032 14.2 0.0 0.065 13.2 0.0 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain DUF4144 PF13642.6 VDK78401.1 - 0.04 14.5 0.1 4.3 8.0 0.0 2.5 2 0 0 2 2 2 0 protein structure with unknown function PLDc PF00614.22 VDK78403.1 - 3.3e-16 58.7 2.7 1.2e-07 31.6 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 VDK78403.1 - 1.7e-13 50.6 0.0 3.1e-07 30.3 0.0 3.1 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 VDK78403.1 - 1.6e-08 34.5 0.1 0.0064 16.5 0.0 2.9 2 0 0 2 2 2 2 PX domain PH PF00169.29 VDK78403.1 - 0.0076 16.8 0.0 0.031 14.8 0.0 2.2 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 VDK78403.1 - 0.087 13.3 0.3 2.3 8.7 0.3 3.0 1 1 0 1 1 1 0 Pleckstrin homology domain FlgD PF03963.14 VDK78403.1 - 0.24 11.7 0.9 0.57 10.5 0.9 1.5 1 0 0 1 1 1 0 Flagellar hook capping protein - N-terminal region N_BRCA1_IG PF16158.5 VDK78452.1 - 0.057 14.1 0.4 8.2 7.2 0.1 2.5 2 0 0 2 2 2 0 Ig-like domain from next to BRCA1 gene HMG_box PF00505.19 VDK78454.1 - 4.3e-17 62.3 3.4 6e-17 61.8 3.4 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK78454.1 - 9.5e-12 45.4 4.1 1.4e-11 44.8 4.1 1.3 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 VDK78454.1 - 0.001 19.0 7.3 0.0013 18.6 6.4 1.8 1 1 0 1 1 1 1 HMG (high mobility group) box 5 Sulfotransfer_2 PF03567.14 VDK78455.1 - 3.1e-52 178.0 0.3 3.9e-52 177.7 0.3 1.1 1 0 0 1 1 1 1 Sulfotransferase family Sigma_reg_N PF13800.6 VDK78455.1 - 0.13 12.5 0.4 0.34 11.2 0.4 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF937 PF06078.11 VDK78456.1 - 0.027 15.1 0.1 5.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF937) Collagen PF01391.18 VDK78458.1 - 6.5e-20 70.6 117.1 3.8e-09 36.1 37.5 4.3 3 2 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK78459.1 - 1.2e-18 66.9 1.3 2.2e-18 66.0 0.5 1.8 2 0 0 2 2 2 1 Nematode cuticle collagen N-terminal domain DUF4199 PF13858.6 VDK78459.1 - 0.029 14.8 0.0 0.03 14.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) IBV_3B PF03622.13 VDK78459.1 - 0.046 13.9 0.0 0.062 13.4 0.0 1.4 1 0 0 1 1 1 0 IBV 3B protein DUF2681 PF10883.8 VDK78459.1 - 0.12 12.8 1.7 1.3 9.5 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) DUF616 PF04765.13 VDK78470.1 - 0.084 12.1 0.0 0.12 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF616) DUF2768 PF10966.8 VDK78470.1 - 5.2 7.6 10.5 5 7.6 2.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) TSP_1 PF00090.19 VDK78473.1 - 4.6e-68 225.3 165.4 1.5e-09 37.9 11.7 10.6 10 0 0 10 10 10 10 Thrombospondin type 1 domain zf-CCCH PF00642.24 VDK78474.1 - 0.00024 20.9 16.9 0.04 13.8 1.3 3.8 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 VDK78474.1 - 0.0077 16.9 18.2 0.21 12.3 0.4 3.6 1 1 2 3 3 3 3 Torus domain zf-C3H1 PF10650.9 VDK78474.1 - 1.9 8.3 5.6 3.7 7.4 0.6 3.0 3 0 0 3 3 3 0 Putative zinc-finger domain zf_CCCH_4 PF18345.1 VDK78474.1 - 2.4 8.3 16.6 0.089 12.9 0.9 3.8 3 0 0 3 3 3 0 Zinc finger domain ECR1_N PF14382.6 VDK78477.1 - 2.5e-10 40.0 0.0 9e-10 38.2 0.0 2.0 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.9 VDK78477.1 - 6.6e-08 33.1 0.0 1.3e-06 29.0 0.0 2.3 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 MCD PF05292.11 VDK78478.1 - 1.6e-86 290.0 0.0 8.8e-86 287.6 0.0 2.0 1 1 0 1 1 1 1 Malonyl-CoA decarboxylase C-terminal domain MCD_N PF17408.2 VDK78478.1 - 1.1e-18 67.1 0.0 2.8e-18 65.8 0.0 1.8 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase N-terminal domain UCH PF00443.29 VDK78480.1 - 3.5e-34 118.5 0.1 7.2e-34 117.4 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK78480.1 - 1.4e-18 67.5 2.8 9.5e-14 51.7 0.0 3.3 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase Vma12 PF11712.8 VDK78482.1 - 3.6e-29 101.6 0.0 4.9e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase TMEM70 PF06979.12 VDK78484.1 - 3.4e-18 66.3 0.9 5.2e-18 65.7 0.9 1.2 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex Trypsin PF00089.26 VDK78485.1 - 2.9e-07 30.5 0.0 7.2e-07 29.2 0.0 1.6 1 1 0 1 1 1 1 Trypsin DuoxA PF10204.9 VDK78486.1 - 8.9e-49 166.0 26.9 6.8e-41 140.1 4.5 3.0 2 1 1 3 3 3 2 Dual oxidase maturation factor DUF5534 PF17686.1 VDK78486.1 - 2.5 8.3 5.9 23 5.2 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5534) Band_7 PF01145.25 VDK78503.1 - 3.1e-30 105.5 0.8 4.1e-30 105.1 0.8 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 VDK78503.1 - 0.0049 16.6 0.3 0.0068 16.1 0.3 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 VDK78503.1 - 0.15 12.5 1.0 0.2 12.1 0.2 1.7 2 0 0 2 2 2 0 Phage protein Gp68 UCR_14kD PF02271.16 VDK78505.1 - 2.1e-22 79.0 0.1 2.8e-22 78.5 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Pro_isomerase PF00160.21 VDK78506.1 - 2.9e-47 160.9 0.3 1.3e-46 158.8 0.3 2.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_S8 PF00082.22 VDK78507.1 - 1.3e-77 261.0 0.0 2e-77 260.4 0.0 1.2 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 VDK78507.1 - 1.7e-58 197.2 0.0 3.1e-58 196.4 0.0 1.4 1 0 0 1 1 1 1 Tripeptidyl peptidase II TPPII_N PF12583.8 VDK78507.1 - 0.00037 21.1 0.1 0.00094 19.8 0.1 1.6 1 0 0 1 1 1 1 Tripeptidyl peptidase II N terminal DEAD PF00270.29 VDK78508.1 - 2.6e-45 154.3 0.2 4.6e-45 153.5 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK78508.1 - 5e-30 104.1 0.1 2.1e-29 102.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK78508.1 - 4.9e-05 23.4 0.3 0.0002 21.4 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4246 PF14033.6 VDK78508.1 - 0.074 12.2 1.5 0.11 11.5 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4246) PBP1_TM PF14812.6 VDK78508.1 - 8.6 6.8 13.5 19 5.7 13.5 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CUB PF00431.20 VDK78509.1 - 1.3e-15 57.6 0.1 2.5e-15 56.8 0.1 1.5 1 0 0 1 1 1 1 CUB domain Lectin_C PF00059.21 VDK78509.1 - 7.3e-11 42.8 0.2 2e-10 41.4 0.1 1.8 2 0 0 2 2 2 1 Lectin C-type domain DHHC PF01529.20 VDK78511.1 - 1.3e-28 99.8 13.3 1.3e-28 99.8 13.3 2.4 3 0 0 3 3 3 1 DHHC palmitoyltransferase BAR PF03114.18 VDK78519.1 - 7.2e-19 68.4 2.7 9.5e-19 68.0 2.7 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 VDK78519.1 - 4.9e-07 29.2 4.3 4.9e-07 29.2 4.3 1.4 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Imm59 PF15597.6 VDK78519.1 - 0.026 15.0 0.4 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 59 Herpes_ICP4_N PF03584.15 VDK78519.1 - 0.13 12.1 0.0 2 8.2 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus ICP4-like protein N-terminal region DBINO PF13892.6 VDK78519.1 - 0.22 11.9 7.7 0.4 11.1 6.9 1.7 1 1 0 1 1 1 0 DNA-binding domain Occludin_ELL PF07303.13 VDK78519.1 - 0.23 12.2 4.6 0.98 10.2 2.3 2.5 2 0 0 2 2 2 0 Occludin homology domain Carb_kinase PF01256.17 VDK78520.1 - 2e-58 197.7 0.0 2.3e-58 197.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 VDK78520.1 - 1.7e-05 24.4 0.0 2.5e-05 23.8 0.0 1.4 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 VDK78520.1 - 0.043 13.2 0.0 0.088 12.2 0.0 1.5 1 1 0 1 1 1 0 Phosphomethylpyrimidine kinase FAD-oxidase_C PF02913.19 VDK78521.1 - 7.7e-52 176.4 0.0 1e-51 176.0 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 VDK78521.1 - 2.5e-33 114.7 0.0 5.4e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain Ribosomal_L11_N PF03946.14 VDK78522.1 - 6.3e-24 83.6 0.2 1e-23 82.9 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 VDK78522.1 - 3.9e-18 65.7 0.7 7.3e-18 64.8 0.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain CAF1 PF04857.20 VDK78523.1 - 9.7e-20 71.0 0.1 2.1e-10 40.3 0.0 2.3 2 1 0 2 2 2 2 CAF1 family ribonuclease Peptidase_M50 PF02163.22 VDK78524.1 - 1.4e-18 67.1 0.0 4.4e-18 65.5 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M50 DUF747 PF05346.11 VDK78524.1 - 0.0083 15.6 0.5 0.029 13.8 0.0 1.9 1 1 1 2 2 2 1 Eukaryotic membrane protein family PDZ_2 PF13180.6 VDK78524.1 - 0.04 14.2 0.0 0.075 13.4 0.0 1.3 1 0 0 1 1 1 0 PDZ domain HECT_2 PF09814.9 VDK78525.1 - 5.2e-22 78.2 0.2 8.1e-22 77.6 0.2 1.2 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Peptidase_S28 PF05577.12 VDK78526.1 - 3.6e-82 276.5 4.7 3.6e-82 276.5 4.7 1.4 2 0 0 2 2 2 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 VDK78526.1 - 0.0001 22.0 0.0 0.00018 21.2 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2920 PF11144.8 VDK78526.1 - 0.0031 16.7 0.0 0.006 15.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Hydrolase_4 PF12146.8 VDK78526.1 - 0.011 15.0 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 VDK78526.1 - 0.02 14.4 0.2 0.059 12.8 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 VDK78526.1 - 0.034 14.7 0.0 0.055 14.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Myotoxins PF00819.17 VDK78526.1 - 1.2 9.4 3.8 0.61 10.4 0.9 2.0 2 0 0 2 2 2 0 Myotoxin, crotamine Peptidase_S28 PF05577.12 VDK78527.1 - 6e-96 321.9 0.0 7.4e-96 321.6 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 VDK78527.1 - 6.4e-06 25.8 0.0 1.1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 VDK78527.1 - 8.9e-06 25.1 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK78527.1 - 4.8e-05 23.1 0.0 7.6e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2920 PF11144.8 VDK78527.1 - 0.011 15.0 0.1 0.015 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Abhydrolase_6 PF12697.7 VDK78527.1 - 0.098 13.2 0.0 0.16 12.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Myotub-related PF06602.14 VDK78529.1 - 1.8e-120 402.1 1.8 9.8e-120 399.7 1.8 2.0 1 1 0 1 1 1 1 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 VDK78529.1 - 1.7e-21 76.7 0.0 2.8e-21 76.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK78529.1 - 3.8e-10 39.6 0.0 7.6e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Ogr_Delta PF04606.12 VDK78529.1 - 0.058 13.4 0.1 0.56 10.2 0.0 2.6 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger AglB_L1 PF18079.1 VDK78529.1 - 0.17 12.2 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 Archaeal glycosylation protein B long peripheral domain FtsJ PF01728.19 VDK78531.1 - 1.2e-58 198.1 0.0 3.7e-58 196.5 0.1 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.8 VDK78531.1 - 1.9e-30 105.9 9.4 1.9e-30 105.9 9.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3381) RcsD_ABL PF16359.5 VDK78531.1 - 0.0065 16.6 0.1 0.068 13.3 0.0 2.5 2 1 0 2 2 2 1 RcsD-ABL domain PVL_ORF50 PF07768.11 VDK78531.1 - 1.2 9.5 9.9 21 5.5 6.5 3.1 2 1 0 2 2 2 0 PVL ORF-50-like family Med19 PF10278.9 VDK78551.1 - 3.2e-44 151.0 5.2 4.1e-44 150.6 5.2 1.1 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 RNA_polI_A34 PF08208.11 VDK78551.1 - 0.56 10.3 18.1 0.79 9.8 18.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 AAA PF00004.29 VDK78552.1 - 3.2e-17 63.2 0.0 5.6e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 VDK78552.1 - 4.7e-16 59.0 0.0 1.2e-15 57.6 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 VDK78552.1 - 3.5e-14 52.9 0.0 6.9e-12 45.5 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_5 PF07728.14 VDK78552.1 - 8.5e-06 25.8 0.1 0.00019 21.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 VDK78552.1 - 9.9e-05 22.3 0.1 0.00027 20.9 0.0 1.9 2 1 0 2 2 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 VDK78552.1 - 0.00014 22.1 0.1 0.00071 19.9 0.0 2.0 2 0 0 2 2 2 1 AAA C-terminal domain RuvB_N PF05496.12 VDK78552.1 - 0.00027 20.7 0.0 0.00055 19.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK78552.1 - 0.00043 20.6 1.9 0.077 13.3 0.3 3.3 2 1 1 3 3 3 1 AAA domain AAA_11 PF13086.6 VDK78552.1 - 0.00074 19.4 0.1 0.0016 18.3 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK78552.1 - 0.00085 19.7 0.1 0.0045 17.4 0.0 2.3 2 1 0 2 2 1 1 AAA ATPase domain DNA_pol3_delta PF06144.13 VDK78552.1 - 0.0011 18.7 0.1 0.0017 18.1 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_24 PF13479.6 VDK78552.1 - 0.0012 18.6 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 VDK78552.1 - 0.0014 18.4 0.0 0.005 16.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 VDK78552.1 - 0.0038 16.8 0.0 0.0092 15.5 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region PhoH PF02562.16 VDK78552.1 - 0.0063 16.0 0.1 0.22 11.0 0.0 2.3 1 1 0 2 2 2 1 PhoH-like protein AAA_19 PF13245.6 VDK78552.1 - 0.0066 16.8 0.1 0.026 14.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 VDK78552.1 - 0.0075 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 VDK78552.1 - 0.017 14.5 0.1 0.16 11.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein DEAD PF00270.29 VDK78552.1 - 0.018 14.8 0.2 0.21 11.3 0.0 2.2 1 1 0 2 2 2 0 DEAD/DEAH box helicase Mg_chelatase PF01078.21 VDK78552.1 - 0.024 14.0 0.0 0.35 10.2 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI ResIII PF04851.15 VDK78552.1 - 0.025 14.6 0.1 0.9 9.5 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit RecR PF02132.15 VDK78552.1 - 0.026 14.1 0.2 0.068 12.8 0.2 1.7 1 0 0 1 1 1 0 RecR protein FtsK_SpoIIIE PF01580.18 VDK78552.1 - 0.048 13.0 0.1 0.2 11.0 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF815 PF05673.13 VDK78552.1 - 0.05 12.8 0.0 0.1 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TIP49 PF06068.13 VDK78552.1 - 0.057 12.6 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 VDK78552.1 - 0.06 13.9 0.0 0.18 12.4 0.0 1.8 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 VDK78552.1 - 0.073 13.6 0.0 0.2 12.1 0.0 1.7 2 0 0 2 2 1 0 ABC transporter SNF2_N PF00176.23 VDK78552.1 - 0.15 10.8 0.0 0.46 9.1 0.0 1.7 1 1 0 1 1 1 0 SNF2 family N-terminal domain Spt20 PF12090.8 VDK78553.1 - 1.6 8.3 22.6 0.0086 15.7 10.2 2.1 1 1 1 2 2 2 0 Spt20 family Astacin PF01400.24 VDK78554.1 - 2.4e-67 226.3 0.0 4e-67 225.6 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 VDK78554.1 - 1.3e-14 54.5 0.1 2.9e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 CUB domain Peptidase_M10 PF00413.24 VDK78554.1 - 0.00035 20.4 0.3 0.68 9.8 0.0 3.1 2 1 1 3 3 3 2 Matrixin EGF_2 PF07974.13 VDK78554.1 - 0.019 15.3 12.7 0.049 14.0 12.7 1.8 1 0 0 1 1 1 0 EGF-like domain Peptidase_M8 PF01457.16 VDK78554.1 - 0.066 11.9 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Leishmanolysin Reprolysin_4 PF13583.6 VDK78554.1 - 0.28 10.8 1.8 2.3 7.8 0.1 2.7 2 1 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Laminin_EGF PF00053.24 VDK78554.1 - 7.7 6.7 11.4 18 5.6 11.4 1.6 1 0 0 1 1 1 0 Laminin EGF domain BCL_N PF04714.13 VDK78557.1 - 6.5e-25 86.9 9.5 1.1e-24 86.2 9.5 1.4 1 0 0 1 1 1 1 BCL7, N-terminal conserver region Stealth_CR2 PF11380.8 VDK78557.1 - 0.04 14.1 0.2 0.057 13.6 0.2 1.2 1 0 0 1 1 1 0 Stealth protein CR2, conserved region 2 DUF1964 PF09244.10 VDK78557.1 - 0.08 13.4 0.8 0.84 10.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1964) Peptidase_M10 PF00413.24 VDK78558.1 - 1.2e-45 155.2 0.0 2.7e-45 154.1 0.0 1.5 1 0 0 1 1 1 1 Matrixin Hemopexin PF00045.19 VDK78558.1 - 4.9e-17 61.6 7.2 0.00015 21.7 0.1 4.5 4 0 0 4 4 4 4 Hemopexin PG_binding_1 PF01471.18 VDK78558.1 - 1.1e-06 28.7 0.0 2.3e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Metallopep PF12044.8 VDK78558.1 - 0.0073 15.0 0.0 0.011 14.4 0.0 1.2 1 0 0 1 1 1 1 Putative peptidase family Peptidase_M66 PF10462.9 VDK78558.1 - 0.062 12.2 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.5 VDK78558.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Reprolysin_3 PF13582.6 VDK78558.1 - 0.14 12.7 0.1 0.96 10.0 0.2 2.2 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 VDK78558.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M54 Cwf_Cwc_15 PF04889.12 VDK78558.1 - 0.86 9.3 6.5 1.6 8.4 6.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 VDK78558.1 - 6.8 4.7 6.7 9.4 4.2 6.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi AMP-binding PF00501.28 VDK78559.1 - 6.2e-64 216.2 0.0 1.1e-63 215.3 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 VDK78559.1 - 2.6e-55 187.4 0.1 1.3e-54 185.1 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein adh_short PF00106.25 VDK78559.1 - 1.4e-54 184.5 2.1 2.4e-54 183.8 0.5 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK78559.1 - 3.4e-39 134.8 0.1 6.6e-39 133.8 0.1 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 VDK78559.1 - 9.4e-21 74.4 2.3 8.8e-16 58.1 0.0 2.8 3 0 0 3 3 3 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 VDK78559.1 - 1.1e-19 70.5 0.6 3.9e-16 58.9 0.1 2.6 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 VDK78559.1 - 5e-18 65.2 0.1 1.3e-17 63.9 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 VDK78559.1 - 1.4e-14 54.4 1.1 3e-11 43.6 0.1 2.6 2 1 0 2 2 2 2 KR domain Polysacc_synt_2 PF02719.15 VDK78559.1 - 2.1e-14 53.3 0.9 1.3e-07 31.1 0.1 2.4 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 VDK78559.1 - 3e-11 43.3 0.0 1.5e-08 34.5 0.0 2.5 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 VDK78559.1 - 6.1e-09 35.4 0.0 1.4e-07 30.9 0.0 2.8 2 1 0 2 2 2 1 RmlD substrate binding domain AMP-binding_C PF13193.6 VDK78559.1 - 1.6e-08 35.4 0.2 7.4e-08 33.3 0.1 2.3 1 1 1 2 2 2 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 VDK78559.1 - 2e-06 27.8 0.0 0.094 12.6 0.0 3.4 2 1 0 2 2 2 2 NAD(P)H-binding Nodulin-like PF06813.13 VDK78559.1 - 0.07 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Nodulin-like Papilin_u7 PF16626.5 VDK78561.1 - 0.074 13.6 0.2 0.11 13.1 0.2 1.1 1 0 0 1 1 1 0 Linking region between Kunitz_BPTI and I-set on papilin Trypsin PF00089.26 VDK78588.1 - 1.3e-14 54.6 3.4 9.6e-13 48.4 3.4 2.2 1 1 0 1 1 1 1 Trypsin DUF316 PF03761.15 VDK78588.1 - 5e-07 29.6 0.1 0.0007 19.2 0.0 2.3 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.6 VDK78588.1 - 0.069 14.0 0.0 0.11 13.3 0.0 1.4 1 0 0 1 1 1 0 Trypsin-like peptidase domain DEAD PF00270.29 VDK78590.1 - 8.8e-46 155.9 0.7 2.1e-45 154.7 0.7 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK78590.1 - 4.2e-33 114.0 0.4 6.2e-32 110.2 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK78590.1 - 2.1e-08 34.3 0.0 3.2e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 VDK78590.1 - 0.00011 22.5 0.2 0.00037 20.8 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK78590.1 - 0.00012 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 VDK78590.1 - 0.0029 17.0 0.0 0.0077 15.6 0.0 1.7 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 VDK78590.1 - 0.0066 16.7 0.1 0.03 14.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 VDK78590.1 - 0.007 16.2 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Helicase Flavi_DEAD PF07652.14 VDK78590.1 - 0.016 15.1 0.2 0.07 13.1 0.2 2.0 1 1 0 1 1 1 0 Flavivirus DEAD domain UvrD-helicase PF00580.21 VDK78590.1 - 0.045 13.3 0.3 0.097 12.2 0.2 1.6 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain fragilysinNterm PF16376.5 VDK78590.1 - 0.077 12.7 0.4 0.61 9.8 0.1 2.5 3 0 0 3 3 3 0 N-terminal domain of fragilysin RhoGEF PF00621.20 VDK78591.1 - 6.2e-17 62.4 0.4 2.2e-16 60.7 0.2 1.9 2 0 0 2 2 2 1 RhoGEF domain SH3_9 PF14604.6 VDK78591.1 - 1.2e-14 53.9 0.0 2e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK78591.1 - 1.5e-11 43.7 0.1 2.9e-11 42.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK78591.1 - 1.4e-09 37.5 0.0 2.5e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3369 PF11849.8 VDK78591.1 - 0.0039 17.4 0.4 0.025 14.8 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3369) RE_AlwI PF09491.10 VDK78591.1 - 0.058 12.2 0.4 0.086 11.6 0.4 1.2 1 0 0 1 1 1 0 AlwI restriction endonuclease betaPIX_CC PF16523.5 VDK78592.1 - 5.2e-19 67.9 4.1 8.4e-19 67.2 4.1 1.4 1 0 0 1 1 1 1 betaPIX coiled coil COG2 PF06148.11 VDK78592.1 - 0.0035 17.4 2.8 0.005 16.9 2.8 1.2 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 CREPT PF16566.5 VDK78592.1 - 0.019 15.2 4.5 0.019 15.2 4.5 1.9 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour GlutR_dimer PF00745.20 VDK78592.1 - 0.022 15.2 1.1 0.044 14.2 1.1 1.5 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain Laminin_II PF06009.12 VDK78592.1 - 0.026 14.6 2.1 0.044 13.8 2.1 1.3 1 0 0 1 1 1 0 Laminin Domain II Cas_APE2256 PF09651.10 VDK78592.1 - 0.039 13.8 0.2 0.072 13.0 0.1 1.4 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) UPF0242 PF06785.11 VDK78592.1 - 0.063 13.4 4.6 0.088 12.9 4.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Tho2 PF11262.8 VDK78592.1 - 0.073 12.3 2.8 0.1 11.7 2.8 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 RhoGEF67_u2 PF16614.5 VDK78592.1 - 0.11 12.6 1.1 0.38 10.9 0.0 2.0 1 1 1 2 2 2 0 Unstructured region two on RhoGEF 6 and 7 DUF4810 PF16068.5 VDK78592.1 - 0.11 13.1 2.2 4.6 7.9 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4810) ABC_tran_Xtn PF12848.7 VDK78592.1 - 0.17 11.9 3.2 0.44 10.6 3.2 1.7 1 0 0 1 1 1 0 ABC transporter DUF1664 PF07889.12 VDK78592.1 - 0.25 11.4 2.4 0.42 10.6 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SlyX PF04102.12 VDK78592.1 - 1.3 9.7 11.0 2.3 8.9 0.8 2.4 1 1 1 2 2 2 0 SlyX Peptidase_S9_N PF02897.15 VDK78593.1 - 4.4e-98 328.8 1.3 1.1e-83 281.4 0.3 2.1 1 1 1 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 VDK78593.1 - 2.2e-58 197.2 0.0 3.9e-58 196.4 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 VDK78593.1 - 0.15 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Fungal_TACC PF12709.7 VDK78594.1 - 0.0071 16.8 2.3 0.0071 16.8 2.3 5.1 4 2 2 6 6 6 1 Fungal Transforming acidic coiled-coil (TACC) proteins HBB PF06777.11 VDK78605.1 - 9.2e-39 133.1 1.3 3.6e-34 118.1 0.3 2.9 3 0 0 3 3 3 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 VDK78605.1 - 7.9e-38 130.3 0.1 1.9e-37 129.0 0.0 1.7 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 VDK78605.1 - 9.6e-25 87.2 0.4 1.6e-24 86.5 0.4 1.4 1 0 0 1 1 1 1 DEAD_2 Cast PF10174.9 VDK78605.1 - 0.0055 15.0 1.8 0.0082 14.4 1.8 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Troponin PF00992.20 VDK78605.1 - 0.015 15.6 2.3 0.034 14.5 2.3 1.5 1 0 0 1 1 1 0 Troponin YabA PF06156.13 VDK78605.1 - 0.29 11.8 1.3 1.1 10.0 1.3 1.9 1 0 0 1 1 1 0 Initiation control protein YabA RhoGAP PF00620.27 VDK78606.1 - 1.1e-32 113.0 0.0 2.2e-32 112.0 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain RA PF00788.23 VDK78606.1 - 0.026 15.2 0.0 0.055 14.1 0.0 1.5 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain CSN8_PSD8_EIF3K PF10075.9 VDK78609.1 - 2.5e-29 102.1 0.1 4.3e-29 101.4 0.1 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family XLF PF09302.11 VDK78610.1 - 0.003 17.8 0.0 0.0063 16.7 0.0 1.5 1 1 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component IP_trans PF02121.18 VDK78611.1 - 3.9e-109 364.0 0.1 4.4e-109 363.8 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Thioredoxin PF00085.20 VDK78618.1 - 0.00013 21.9 0.0 0.00029 20.8 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin DUF5358 PF17311.2 VDK78618.1 - 0.014 15.5 0.9 0.023 14.7 0.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5358) BTG PF07742.12 VDK78620.1 - 9.4e-10 38.4 0.0 2.2e-09 37.2 0.0 1.6 1 1 0 1 1 1 1 BTG family SATase_N PF06426.14 VDK78620.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal GHMP_kinases_N PF00288.26 VDK78621.1 - 8e-14 51.6 0.3 2.4e-13 50.1 0.3 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 VDK78621.1 - 9.2e-08 32.4 0.0 2.4e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 VDK78621.1 - 0.017 14.6 0.0 0.036 13.6 0.0 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature Astacin PF01400.24 VDK78633.1 - 3.6e-63 212.7 0.0 5.7e-63 212.0 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 VDK78633.1 - 8.3e-05 22.5 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 2 Matrixin Reprolysin_4 PF13583.6 VDK78633.1 - 0.0016 18.2 0.0 0.0024 17.5 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 VDK78633.1 - 0.015 14.3 0.3 0.022 13.7 0.3 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.5 VDK78633.1 - 0.12 11.5 0.9 0.33 10.1 0.2 1.9 2 1 0 2 2 2 0 Met-zincin KH_1 PF00013.29 VDK78635.1 - 7.4e-05 22.5 0.4 0.00014 21.6 0.4 1.5 1 0 0 1 1 1 1 KH domain CUB PF00431.20 VDK78636.1 - 3e-13 50.1 0.0 5.4e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 CUB domain Phage_portal_2 PF05136.13 VDK78637.1 - 0.068 12.3 0.0 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 Phage portal protein, lambda family Fringe PF02434.16 VDK78638.1 - 2.5e-51 174.6 0.0 2.8e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 Fringe-like CBM_14 PF01607.24 VDK78641.1 - 1.2e-178 579.3 308.6 8e-11 41.9 5.1 27.3 27 0 0 27 27 27 26 Chitin binding Peritrophin-A domain GoLoco PF02188.17 VDK78641.1 - 0.26 10.8 1.3 0.6 9.7 1.3 1.7 1 0 0 1 1 1 0 GoLoco motif START PF01852.19 VDK78644.1 - 1.2e-13 50.9 0.0 1.4e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 START domain Pkinase PF00069.25 VDK78645.1 - 1.7e-39 135.8 0.0 2.3e-38 132.1 0.0 2.4 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78645.1 - 3.2e-15 56.1 0.0 1.6e-14 53.9 0.0 2.0 1 1 1 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 VDK78645.1 - 2.5e-05 23.7 0.0 4.8e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 VDK78645.1 - 7.6e-05 21.7 0.2 0.00013 20.9 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK78645.1 - 0.0013 18.7 0.0 0.0013 18.7 0.0 2.4 3 1 0 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 VDK78645.1 - 0.073 12.7 0.1 0.15 11.6 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 VDK78649.1 - 5.1e-85 285.0 0.0 3.7e-68 229.7 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78649.1 - 1.4e-61 208.1 0.0 2.9e-41 141.5 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Guanylate_cyc PF00211.20 VDK78649.1 - 6.6e-50 169.3 0.0 1.3e-49 168.3 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PBD PF00786.28 VDK78649.1 - 1.8e-23 82.7 0.0 5.9e-23 81.0 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain ANF_receptor PF01094.28 VDK78649.1 - 1.9e-06 27.2 0.0 3.5e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Receptor family ligand binding region Pkinase_fungal PF17667.1 VDK78649.1 - 6.6e-05 21.8 0.0 0.00016 20.6 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 VDK78649.1 - 0.00013 21.4 0.0 0.0032 16.8 0.0 2.7 1 1 1 2 2 2 1 Kinase-like HNOBA PF07701.14 VDK78649.1 - 0.0068 15.9 1.4 0.016 14.7 1.4 1.6 1 0 0 1 1 1 1 Heme NO binding associated Kdo PF06293.14 VDK78649.1 - 0.013 14.9 0.0 0.037 13.4 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 VDK78649.1 - 0.072 12.1 0.1 0.59 9.1 0.1 2.2 2 0 0 2 2 2 0 Seadornavirus VP7 IMD PF08397.11 VDK78649.1 - 0.098 12.0 1.0 0.24 10.8 1.0 1.6 1 0 0 1 1 1 0 IRSp53/MIM homology domain TFIIA PF03153.13 VDK78649.1 - 1.3 8.9 12.6 2.1 8.2 12.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_Rpb1_5 PF04998.17 VDK78650.1 - 3.7e-104 347.9 0.0 6.3e-104 347.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 VDK78650.1 - 1.3e-99 333.5 0.0 1.9e-99 332.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 VDK78650.1 - 2.1e-74 249.3 0.0 4.3e-74 248.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 VDK78650.1 - 2.3e-66 223.3 0.5 4.1e-66 222.5 0.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 VDK78650.1 - 2.2e-55 186.4 1.1 6.2e-55 184.9 1.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 VDK78650.1 - 1.9e-47 161.1 0.0 5.1e-47 159.7 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 VDK78650.1 - 5.1e-34 116.5 0.0 1.2e-33 115.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 VDK78650.1 - 5.1e-12 45.5 432.7 0.02 15.2 15.1 24.4 20 5 4 25 25 25 18 RNA polymerase Rpb1 C-terminal repeat AcetDehyd-dimer PF09290.11 VDK78650.1 - 0.18 12.0 0.2 0.86 9.8 0.1 2.1 2 0 0 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation Collagen PF01391.18 VDK78651.1 - 1e-24 86.0 85.5 3.5e-10 39.5 32.0 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Neur_chan_LBD PF02931.23 VDK78652.1 - 6.4e-53 179.4 0.8 9.5e-53 178.8 0.8 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK78652.1 - 2e-49 168.8 10.0 2.7e-48 165.1 10.0 2.0 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region NrsF PF06532.11 VDK78652.1 - 0.18 11.5 1.5 0.35 10.5 1.5 1.4 1 0 0 1 1 1 0 Negative regulator of sigma F EMP70 PF02990.16 VDK78653.1 - 1.3e-211 703.8 15.6 1.3e-211 703.8 15.6 1.4 2 0 0 2 2 2 1 Endomembrane protein 70 zf-CCCH PF00642.24 VDK78662.1 - 2.5e-12 46.4 28.2 3.2e-06 26.9 0.4 4.6 5 0 0 5 5 5 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK78662.1 - 2.1e-08 34.0 10.9 1.2e-06 28.3 2.6 5.7 6 1 1 7 7 7 2 Zinc finger domain Torus PF16131.5 VDK78662.1 - 3.6e-07 30.8 28.6 0.00088 19.9 0.5 5.3 1 1 2 5 5 5 4 Torus domain zf-CCCH_4 PF18044.1 VDK78662.1 - 6.6e-07 29.0 6.0 5.5e-06 26.0 0.3 4.7 5 0 0 5 5 5 2 CCCH-type zinc finger zf-CCHC PF00098.23 VDK78662.1 - 0.00014 21.8 29.8 0.00015 21.7 5.7 3.8 4 0 0 4 4 4 2 Zinc knuckle zf-CCCH_3 PF15663.5 VDK78662.1 - 0.0053 17.0 20.3 0.017 15.3 1.8 3.7 1 1 2 3 3 3 2 Zinc-finger containing family zf-C3H1 PF10650.9 VDK78662.1 - 0.039 13.7 13.2 0.57 10.0 0.6 4.1 3 0 0 3 3 3 0 Putative zinc-finger domain zf-CCHC_3 PF13917.6 VDK78662.1 - 0.04 13.9 7.9 0.078 13.0 0.7 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCCH_2 PF14608.6 VDK78662.1 - 0.25 11.9 30.5 0.43 11.1 1.0 5.2 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger zf-CCHC_4 PF14392.6 VDK78662.1 - 0.31 10.8 12.5 2.6 7.8 1.5 2.7 2 0 0 2 2 2 0 Zinc knuckle Sad1_UNC PF07738.13 VDK78664.1 - 3.1e-34 117.8 0.2 7.1e-34 116.7 0.2 1.7 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal PAS_12 PF18095.1 VDK78664.1 - 0.064 12.9 2.5 0.081 12.6 0.1 2.4 2 1 0 2 2 2 0 UPF0242 C-terminal PAS-like domain Peptidase_S46 PF10459.9 VDK78664.1 - 0.29 9.7 13.2 0.43 9.2 13.2 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF4834 PF16118.5 VDK78664.1 - 0.3 12.1 8.0 8.5 7.4 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Uteroglobin PF01099.17 VDK78664.1 - 3 8.2 5.2 1.6 9.1 0.1 3.2 2 2 2 4 4 4 0 Uteroglobin family DUF1077 PF06417.12 VDK78665.1 - 8.8e-46 154.8 7.0 1.1e-45 154.4 7.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) AAA PF00004.29 VDK78666.1 - 7e-43 146.2 0.0 1.9e-42 144.8 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK78666.1 - 3.1e-07 30.1 0.0 5.6e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 VDK78666.1 - 2e-05 25.0 0.1 0.00044 20.7 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 VDK78666.1 - 3e-05 24.3 0.0 0.0068 16.7 0.1 2.8 1 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 VDK78666.1 - 0.00022 21.3 0.0 0.0016 18.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 VDK78666.1 - 0.0021 18.0 0.0 0.26 11.2 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 VDK78666.1 - 0.0024 17.9 0.0 0.0045 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 VDK78666.1 - 0.0029 18.1 0.0 0.0069 16.9 0.0 1.7 2 0 0 2 2 2 1 ABC transporter RNA_helicase PF00910.22 VDK78666.1 - 0.0042 17.4 0.0 0.011 16.1 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 VDK78666.1 - 0.0095 16.5 0.0 0.031 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 VDK78666.1 - 0.01 15.4 0.0 0.021 14.3 0.0 1.6 1 1 1 2 2 2 0 P-loop containing dynein motor region ATPase_2 PF01637.18 VDK78666.1 - 0.017 15.0 0.0 0.96 9.3 0.1 2.5 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea RuvB_N PF05496.12 VDK78666.1 - 0.02 14.7 0.0 0.06 13.1 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 VDK78666.1 - 0.021 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain TsaE PF02367.17 VDK78666.1 - 0.024 14.7 0.0 0.051 13.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin PF02224.18 VDK78666.1 - 0.036 13.8 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_2 PF07724.14 VDK78666.1 - 0.044 13.9 0.0 0.14 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 VDK78666.1 - 0.049 12.8 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Cytidylate_kin2 PF13189.6 VDK78666.1 - 0.057 13.6 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase-like family AAA_17 PF13207.6 VDK78666.1 - 0.064 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 VDK78666.1 - 0.081 12.5 0.0 0.41 10.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 VDK78666.1 - 0.092 13.0 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 VDK78666.1 - 0.13 11.9 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 VDK78666.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Mg_chelatase PF01078.21 VDK78666.1 - 0.21 11.0 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI CRAL_TRIO PF00650.20 VDK78667.1 - 1.7e-21 76.6 0.2 2.7e-21 75.9 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain GOLD_2 PF13897.6 VDK78667.1 - 0.016 15.7 0.1 0.052 14.0 0.1 1.9 1 1 0 1 1 1 0 Golgi-dynamics membrane-trafficking PEX-1N PF09262.11 VDK78668.1 - 6.7e-13 48.9 0.4 1.7e-12 47.5 0.4 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA PF00004.29 VDK78668.1 - 5.4e-11 43.0 0.0 2.9e-10 40.7 0.0 2.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 VDK78668.1 - 1.8e-05 25.2 0.4 0.035 14.5 0.0 2.5 1 1 1 2 2 2 2 AAA ATPase domain AAA_14 PF13173.6 VDK78668.1 - 0.01 15.9 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRPRB PF09439.10 VDK78668.1 - 0.034 13.6 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 VDK78668.1 - 0.043 14.0 1.6 1.6 9.0 0.1 2.3 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 VDK78668.1 - 0.065 13.7 0.0 0.44 11.0 0.0 2.1 2 1 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 VDK78668.1 - 0.086 13.1 0.4 1.4 9.2 0.4 2.6 1 1 0 1 1 1 0 AAA domain STT3 PF02516.14 VDK78670.1 - 2.6e-142 475.2 44.1 4.3e-138 461.3 39.3 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 VDK78670.1 - 2.6e-06 27.8 11.6 2.6e-06 27.8 11.6 3.5 4 0 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Bac_export_2 PF01312.19 VDK78670.1 - 0.091 12.0 2.5 0.19 10.9 2.1 1.8 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family U-box PF04564.15 VDK78671.1 - 1.5e-30 105.2 0.1 6.6e-30 103.1 0.0 2.2 3 0 0 3 3 1 1 U-box domain CHIP_TPR_N PF18391.1 VDK78671.1 - 6.8e-25 87.6 13.7 1.3e-24 86.7 13.7 1.5 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_1 PF00515.28 VDK78671.1 - 1.3e-18 65.9 0.6 1.4e-07 31.0 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 VDK78671.1 - 6.1e-17 60.3 0.4 0.00022 21.1 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK78671.1 - 8.9e-11 41.9 0.8 8e-10 38.8 0.5 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 VDK78671.1 - 1.4e-10 41.3 0.9 3.3e-06 27.3 0.1 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK78671.1 - 1.6e-08 34.1 0.1 0.0012 18.5 0.0 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 VDK78671.1 - 2.2e-08 33.7 0.0 0.02 15.1 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK78671.1 - 2.3e-08 34.5 0.0 8.4e-05 23.1 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK78671.1 - 2.9e-08 34.1 0.0 0.00014 22.3 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK78671.1 - 2e-07 30.5 0.3 0.007 16.3 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK78671.1 - 1.8e-05 25.2 0.0 0.27 12.2 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK78671.1 - 3.2e-05 24.0 0.0 0.014 15.5 0.0 2.7 1 1 2 3 3 3 2 Tetratricopeptide repeat zf-NOSIP PF15906.5 VDK78671.1 - 0.0021 18.1 0.0 0.0048 17.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein DUF2785 PF10978.8 VDK78671.1 - 0.0056 16.5 0.7 0.013 15.2 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2785) TPR_6 PF13174.6 VDK78671.1 - 0.006 17.1 0.2 12 6.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK78671.1 - 0.014 15.7 0.8 8.9 6.9 0.0 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat Pex26 PF07163.12 VDK78671.1 - 0.043 13.1 0.2 0.067 12.5 0.2 1.4 1 1 0 1 1 1 0 Pex26 protein POTRA PF07244.15 VDK78671.1 - 0.064 13.8 1.1 22 5.7 0.0 2.9 3 1 0 3 3 3 0 Surface antigen variable number repeat TPR_MalT PF17874.1 VDK78671.1 - 0.067 12.6 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 MalT-like TPR region TPR_10 PF13374.6 VDK78671.1 - 0.074 13.0 0.4 8.7 6.4 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TEX29 PF15839.5 VDK78671.1 - 0.12 13.0 0.0 0.25 11.9 0.0 1.6 1 1 0 1 1 1 0 Testis-expressed sequence 29 protein Arm PF00514.23 VDK78672.1 - 2.5e-76 249.6 21.4 3.4e-12 45.9 0.3 8.9 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 VDK78672.1 - 1.6e-25 88.4 7.4 5.4e-23 80.3 4.0 3.0 3 0 0 3 3 3 2 Atypical Arm repeat IBB PF01749.20 VDK78672.1 - 2.6e-21 75.8 3.8 6e-20 71.5 3.2 2.6 2 0 0 2 2 2 1 Importin beta binding domain HEAT_EZ PF13513.6 VDK78672.1 - 2.5e-20 72.6 4.7 8.9e-08 32.5 0.1 6.1 5 1 1 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 VDK78672.1 - 3.1e-15 56.3 0.9 0.016 15.6 0.1 5.4 2 2 3 5 5 5 3 HEAT repeats HEAT PF02985.22 VDK78672.1 - 2.2e-14 52.3 4.0 0.0027 17.8 0.0 6.4 7 0 0 7 7 7 3 HEAT repeat Adaptin_N PF01602.20 VDK78672.1 - 4.7e-07 28.8 0.2 1.3e-05 24.0 0.1 2.9 1 1 1 2 2 2 2 Adaptin N terminal region V-ATPase_H_C PF11698.8 VDK78672.1 - 7.3e-06 26.1 0.4 1.3 9.2 0.0 4.8 4 1 0 5 5 5 1 V-ATPase subunit H Arm_2 PF04826.13 VDK78672.1 - 1.8e-05 24.4 4.8 0.0076 15.7 0.4 3.9 2 1 1 4 4 4 1 Armadillo-like Cnd1 PF12717.7 VDK78672.1 - 0.00052 20.1 0.2 0.97 9.5 0.1 3.6 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 PUL PF08324.11 VDK78672.1 - 0.034 13.4 1.8 1.1 8.4 0.2 2.7 2 2 0 2 2 2 0 PUL domain Mo25 PF08569.11 VDK78672.1 - 0.041 13.2 0.0 3.5 6.9 0.0 2.5 2 1 1 3 3 3 0 Mo25-like CTNNBL PF08216.11 VDK78672.1 - 0.068 13.3 2.3 13 6.0 0.1 4.4 3 2 2 5 5 5 0 Catenin-beta-like, Arm-motif containing nuclear NopRA1 PF16201.5 VDK78672.1 - 0.074 12.6 0.1 4.7 6.7 0.0 3.4 4 2 1 5 5 5 0 Nucleolar pre-ribosomal-associated protein 1 MMS19_N PF14500.6 VDK78672.1 - 0.18 11.4 0.0 0.92 9.0 0.0 2.2 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II OATP PF03137.20 VDK78674.1 - 2.3e-132 442.1 13.8 9.5e-132 440.1 13.1 1.8 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 VDK78674.1 - 3.1e-19 69.1 28.9 3.3e-18 65.8 18.5 3.4 2 2 0 2 2 2 2 Major Facilitator Superfamily PIG-P PF08510.12 VDK78674.1 - 0.86 9.5 5.6 6.9 6.6 0.0 3.8 4 1 0 4 4 4 0 PIG-P TMEM52 PF14979.6 VDK78686.1 - 0.14 12.0 0.1 0.14 12.0 0.1 2.2 2 0 0 2 2 2 0 Transmembrane 52 CopD PF05425.13 VDK78686.1 - 0.19 12.2 0.0 0.36 11.2 0.0 1.4 1 0 0 1 1 1 0 Copper resistance protein D Ribosomal_S6 PF01250.17 VDK78687.1 - 8.1e-08 32.4 0.0 1.3e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S6 BBIP10 PF14777.6 VDK78688.1 - 1.3e-19 69.5 6.7 2.6e-19 68.5 5.2 1.9 1 1 1 2 2 2 1 Cilia BBSome complex subunit 10 VWA_2 PF13519.6 VDK78691.1 - 1.6e-25 89.8 0.0 8e-25 87.6 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.14 VDK78691.1 - 1.3e-11 44.6 0.2 2.3e-11 43.9 0.2 1.3 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 VDK78691.1 - 4.1e-08 33.7 0.1 8.9e-08 32.6 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 VDK78691.1 - 7.5e-07 28.6 13.7 0.00028 20.6 1.6 3.2 3 0 0 3 3 3 2 Ubiquitin interaction motif Fer4_14 PF13394.6 VDK78691.1 - 0.0074 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain RPN13_C PF16550.5 VDK78691.1 - 0.043 14.0 0.1 0.12 12.5 0.1 1.8 1 0 0 1 1 1 0 UCH-binding domain RAP80_UIM PF18282.1 VDK78691.1 - 0.059 13.2 5.0 0.16 11.8 0.7 3.3 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif PDCD9 PF07147.12 VDK78692.1 - 1.6e-67 228.7 0.0 2.3e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S30 (PDCD9) UCH PF00443.29 VDK78693.1 - 3.6e-31 108.6 0.0 9.5e-31 107.2 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK78693.1 - 1.8e-08 34.4 6.2 1.6e-06 28.0 0.0 4.2 4 1 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 VDK78693.1 - 3.3e-05 23.6 0.1 3.3e-05 23.6 0.1 2.9 3 0 0 3 3 3 1 Ubiquitin family TBK1_ULD PF18396.1 VDK78693.1 - 0.057 13.4 0.9 10 6.1 0.6 2.6 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain zf-C3HC PF07967.13 VDK78693.1 - 0.077 13.0 2.7 1.2 9.2 0.1 3.1 2 1 0 2 2 2 0 C3HC zinc finger-like Ubiquitin_2 PF14560.6 VDK78693.1 - 0.11 13.0 0.1 0.37 11.3 0.1 1.9 1 0 0 1 1 1 0 Ubiquitin-like domain DARPP-32 PF05395.12 VDK78693.1 - 2.5 8.3 5.3 5.6 7.2 5.3 1.5 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 SNRNP27 PF08648.12 VDK78694.1 - 2.2e-28 98.1 0.5 5.2e-28 96.9 0.5 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Presenilin PF01080.17 VDK78694.1 - 2.8 6.6 8.0 3 6.5 8.0 1.0 1 0 0 1 1 1 0 Presenilin Y_phosphatase PF00102.27 VDK78695.1 - 3.4e-35 121.7 0.1 1.2e-34 120.0 0.0 1.7 1 1 1 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 VDK78695.1 - 5.6e-05 23.2 0.0 8.4e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 VDK78695.1 - 6.4e-05 22.8 0.1 0.00015 21.6 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain SMC_N PF02463.19 VDK78695.1 - 0.0094 15.4 0.1 0.45 9.9 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain Fun_ATP-synt_8 PF05933.13 VDK78695.1 - 0.027 14.7 0.1 0.072 13.3 0.1 1.8 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) C12orf66_like PF09404.10 VDK78695.1 - 0.078 11.8 0.2 4.4 6.0 0.1 2.1 2 0 0 2 2 2 0 KICSTOR complex C12orf66 like DUF1910 PF08928.10 VDK78695.1 - 0.1 12.6 0.4 1.4 9.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Adeno_Penton_B PF01686.17 VDK78695.1 - 0.13 10.7 0.1 3.1 6.2 0.1 2.2 2 0 0 2 2 2 0 Adenovirus penton base protein HORMA PF02301.18 VDK78698.1 - 6.8e-27 94.4 0.1 1.2e-26 93.7 0.1 1.4 1 0 0 1 1 1 1 HORMA domain Snf7 PF03357.21 VDK78700.1 - 4.9e-16 58.8 3.9 6.7e-16 58.4 3.9 1.2 1 0 0 1 1 1 1 Snf7 DZF PF07528.14 VDK78718.1 - 2.2e-17 63.5 0.0 3.9e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 DZF domain NTP_transf_2 PF01909.23 VDK78718.1 - 0.077 13.3 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase domain DZF PF07528.14 VDK78721.1 - 8.9e-56 189.3 0.2 1.1e-55 189.0 0.2 1.1 1 0 0 1 1 1 1 DZF domain Nuf2 PF03800.14 VDK78723.1 - 1.1e-15 58.0 0.7 1.1e-15 58.0 0.7 2.6 2 1 0 2 2 2 1 Nuf2 family Flagellar_rod PF05149.12 VDK78723.1 - 0.0026 17.3 17.0 0.0026 17.3 17.0 3.0 2 1 1 3 3 3 1 Paraflagellar rod protein Syntaxin PF00804.25 VDK78723.1 - 0.0032 17.2 12.2 0.0032 17.2 12.2 3.3 1 1 1 2 2 1 1 Syntaxin FAS_N PF17828.1 VDK78723.1 - 0.4 10.7 4.8 0.45 10.5 0.6 3.2 4 1 0 4 4 4 0 N-terminal domain in fatty acid synthase subunit beta Usp PF00582.26 VDK78723.1 - 0.49 10.9 2.7 1.5 9.4 2.6 1.9 1 1 0 1 1 1 0 Universal stress protein family MAD PF05557.13 VDK78723.1 - 0.62 8.4 41.1 1.1 7.5 41.1 1.4 1 1 0 1 1 1 0 Mitotic checkpoint protein PI3K_P85_iSH2 PF16454.5 VDK78723.1 - 0.69 9.5 37.0 0.41 10.2 16.3 4.7 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Spc7 PF08317.11 VDK78723.1 - 1.7 7.4 44.6 0.4 9.5 9.4 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 VDK78723.1 - 1.8 8.6 26.3 0.17 11.9 7.4 4.0 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) FUSC PF04632.12 VDK78723.1 - 1.9 6.9 3.2 1.2 7.6 1.2 1.6 2 1 0 2 2 2 0 Fusaric acid resistance protein family NPV_P10 PF05531.12 VDK78723.1 - 3.3 8.2 16.5 1.1 9.8 1.5 4.7 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Prominin PF05478.11 VDK78723.1 - 3.9 5.3 25.8 0.083 10.8 8.2 2.5 1 1 1 2 2 2 0 Prominin DUF4413 PF14372.6 VDK78723.1 - 4 7.9 7.0 19 5.7 0.1 4.1 3 1 2 5 5 5 0 Domain of unknown function (DUF4413) Fez1 PF06818.15 VDK78723.1 - 7.5 6.9 41.5 2.1 8.8 4.7 3.1 1 1 2 3 3 3 0 Fez1 WXG100 PF06013.12 VDK78723.1 - 8.5 6.7 7.7 23 5.3 0.1 4.5 3 1 2 5 5 5 0 Proteins of 100 residues with WXG InaF-motif PF15018.6 VDK78726.1 - 1.4e-17 63.3 4.1 2.1e-17 62.7 4.1 1.3 1 0 0 1 1 1 1 TRP-interacting helix DUF4083 PF13314.6 VDK78727.1 - 0.024 14.6 0.3 0.059 13.3 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Tmemb_9 PF05434.11 VDK78727.1 - 0.058 13.3 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 TMEM9 DUF1418 PF07214.12 VDK78727.1 - 0.081 12.8 0.1 0.89 9.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) DUF2613 PF11021.8 VDK78727.1 - 0.23 11.6 0.0 0.54 10.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) EF-hand_7 PF13499.6 VDK78728.1 - 0.0023 18.3 0.4 0.17 12.4 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 VDK78728.1 - 0.0065 16.3 0.4 0.1 12.5 0.1 2.8 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 VDK78728.1 - 0.0068 15.9 0.5 0.16 11.5 0.1 3.2 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 VDK78728.1 - 0.0091 15.9 1.1 0.45 10.6 0.0 3.3 4 0 0 4 4 4 1 EF-hand domain LAMTOR PF15454.6 VDK78730.1 - 3.9e-05 24.2 0.0 9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 7tm_7 PF08395.12 VDK78736.1 - 0.042 13.1 0.2 0.05 12.8 0.2 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor HMG_CoA_synt_C PF08540.10 VDK78738.1 - 1.2e-68 231.8 0.1 1.5e-68 231.4 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 VDK78738.1 - 4.7e-62 208.9 0.7 9.8e-62 207.9 0.7 1.5 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Metallophos PF00149.28 VDK78740.1 - 3e-19 70.3 1.9 4.5e-19 69.8 1.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 VDK78740.1 - 1.5e-08 35.0 1.7 1.8e-07 31.5 1.7 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MutL PF13941.6 VDK78740.1 - 0.31 9.6 0.0 0.41 9.2 0.0 1.1 1 0 0 1 1 1 0 MutL protein WW PF00397.26 VDK78744.1 - 6.7e-09 35.7 4.2 1.2e-08 34.9 3.1 2.0 2 0 0 2 2 2 1 WW domain Cid2 PF09774.9 VDK78745.1 - 7.9e-13 49.1 6.2 7.6e-08 32.9 0.5 2.0 1 1 1 2 2 2 2 Caffeine-induced death protein 2 DUF543 PF04418.12 VDK78747.1 - 8.6e-11 41.7 0.0 1.3e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF543) Y_phosphatase PF00102.27 VDK78749.1 - 1.2e-69 234.5 0.0 1.6e-69 234.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK78749.1 - 0.0026 17.5 0.2 0.0079 16.0 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain WD40 PF00400.32 VDK78751.1 - 8e-18 64.5 6.0 0.0034 18.2 0.2 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK78751.1 - 0.0032 17.7 0.2 0.17 12.2 0.4 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 VDK78751.1 - 0.044 12.4 0.9 0.14 10.7 0.1 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 EF-hand_1 PF00036.32 VDK78752.1 - 2.6e-21 73.5 11.1 3.6e-07 29.3 0.3 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 VDK78752.1 - 1.1e-20 73.8 8.1 2e-13 50.5 0.2 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 VDK78752.1 - 2.3e-20 70.7 7.5 5.6e-06 25.9 0.2 4.6 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 VDK78752.1 - 1.3e-12 47.3 7.6 2.3e-07 30.5 0.8 3.7 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK78752.1 - 7.1e-11 41.1 6.5 9.2e-05 21.8 0.3 3.8 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 VDK78752.1 - 5.2e-08 32.8 2.6 0.07 13.1 0.0 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDK78752.1 - 0.00055 20.2 2.9 0.23 11.8 2.6 3.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 VDK78752.1 - 0.00086 19.6 0.0 0.026 14.9 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 VDK78752.1 - 0.023 14.9 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Dockerin type I domain Homez PF11569.8 VDK78752.1 - 0.053 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez DUF5301 PF17225.3 VDK78752.1 - 0.064 13.7 0.1 0.14 12.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) Caleosin PF05042.13 VDK78752.1 - 0.9 9.5 3.7 47 3.9 0.0 3.4 3 1 1 4 4 4 0 Caleosin related protein AAA PF00004.29 VDK78753.1 - 5.2e-39 133.7 0.0 1.1e-38 132.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK78753.1 - 1.5e-11 43.9 0.7 6.2e-11 41.9 0.1 2.4 2 0 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 VDK78753.1 - 3e-08 33.5 0.0 9.6e-08 31.9 0.0 1.9 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.14 VDK78753.1 - 5.8e-05 23.3 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 VDK78753.1 - 6.8e-05 23.1 0.0 0.00021 21.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 VDK78753.1 - 8.4e-05 22.4 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 VDK78753.1 - 0.00015 21.7 0.1 0.00095 19.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 VDK78753.1 - 0.00061 20.2 0.1 0.0057 17.1 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 VDK78753.1 - 0.00082 19.7 0.3 0.034 14.4 0.2 2.7 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 VDK78753.1 - 0.0015 18.5 0.0 0.0071 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 VDK78753.1 - 0.0023 17.7 0.0 0.0047 16.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 VDK78753.1 - 0.0035 16.7 0.1 0.0073 15.7 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 VDK78753.1 - 0.0051 16.1 0.0 0.0098 15.1 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain ATPase PF06745.13 VDK78753.1 - 0.0097 15.3 0.0 2.3 7.5 0.0 2.4 1 1 1 2 2 2 1 KaiC NACHT PF05729.12 VDK78753.1 - 0.013 15.4 0.2 0.055 13.4 0.1 2.0 1 1 1 2 2 2 0 NACHT domain AAA_24 PF13479.6 VDK78753.1 - 0.016 14.9 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 VDK78753.1 - 0.024 14.6 0.0 0.047 13.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 VDK78753.1 - 0.026 15.1 0.2 0.18 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 VDK78753.1 - 0.03 13.8 0.0 0.074 12.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 VDK78753.1 - 0.035 14.3 0.1 0.09 13.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 VDK78753.1 - 0.044 13.2 0.1 0.096 12.1 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 VDK78753.1 - 0.063 13.7 0.0 0.22 11.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Guanylate_kin PF00625.21 VDK78753.1 - 0.08 12.6 0.0 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Guanylate kinase AAA_30 PF13604.6 VDK78753.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 VDK78753.1 - 0.17 11.0 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Rad10 PF03834.14 VDK78754.1 - 5.4e-37 126.3 0.0 1.2e-36 125.2 0.0 1.6 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 VDK78754.1 - 1e-06 29.2 0.0 1.6e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 VDK78754.1 - 7.4e-06 26.0 0.0 1.3e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.23 VDK78754.1 - 0.00099 18.9 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif ParA PF10609.9 VDK78755.1 - 5.5e-92 307.7 0.0 6.4e-92 307.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 VDK78755.1 - 1.2e-11 44.7 0.0 7.6e-11 42.2 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 VDK78755.1 - 6.7e-08 32.6 0.2 9.7e-07 28.9 0.2 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 VDK78755.1 - 3e-06 26.6 1.6 0.00012 21.4 0.2 2.9 1 1 2 3 3 3 1 Anion-transporting ATPase MipZ PF09140.11 VDK78755.1 - 2.1e-05 23.9 0.0 3.8e-05 23.1 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ AAA_26 PF13500.6 VDK78755.1 - 9.8e-05 22.3 0.0 0.085 12.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain Fer4_NifH PF00142.18 VDK78755.1 - 0.00025 20.6 0.0 0.015 14.8 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_16 PF13191.6 VDK78755.1 - 0.00035 21.0 0.1 0.00064 20.1 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 VDK78755.1 - 0.00091 18.9 0.0 0.0016 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain UBZ_FAAP20 PF15750.5 VDK78755.1 - 0.0069 16.3 0.2 0.0069 16.3 0.2 2.7 2 0 0 2 2 2 1 Ubiquitin-binding zinc-finger Rad17 PF03215.15 VDK78755.1 - 0.01 15.8 0.1 0.029 14.3 0.0 1.8 2 0 0 2 2 1 0 Rad17 P-loop domain AAA_5 PF07728.14 VDK78755.1 - 0.024 14.6 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CBP_BcsQ PF06564.12 VDK78755.1 - 0.027 13.9 0.1 0.081 12.4 0.1 1.9 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ RsgA_GTPase PF03193.16 VDK78755.1 - 0.029 14.3 0.0 0.068 13.1 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase DnaB_C PF03796.15 VDK78755.1 - 0.037 13.4 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_18 PF13238.6 VDK78755.1 - 0.038 14.5 0.0 0.066 13.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 VDK78755.1 - 0.039 14.3 0.0 0.16 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.20 VDK78755.1 - 0.039 13.8 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase NB-ARC PF00931.22 VDK78755.1 - 0.041 13.1 0.0 0.066 12.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 VDK78755.1 - 0.073 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 VDK78755.1 - 0.083 12.8 0.2 0.15 12.0 0.2 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 VDK78755.1 - 0.09 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 VDK78755.1 - 0.098 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 VDK78755.1 - 0.19 11.2 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ketoacyl-synt PF00109.26 VDK78757.1 - 1.8e-43 148.9 1.4 1.8e-43 148.9 1.4 1.9 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 VDK78757.1 - 6.9e-27 93.8 0.6 1.2e-26 93.0 0.6 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 VDK78757.1 - 0.0016 18.8 0.0 0.0037 17.7 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension cobW PF02492.19 VDK78757.1 - 0.059 13.0 0.1 0.098 12.2 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain C2 PF00168.30 VDK78760.1 - 3.2e-37 126.9 0.1 2.9e-19 69.3 0.1 2.2 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 VDK78760.1 - 1.3e-05 24.8 0.0 0.081 12.5 0.0 2.9 2 1 0 2 2 2 2 CEP76 C2 domain PIP5K PF01504.18 VDK78763.1 - 7.3e-73 245.2 0.5 1.1e-72 244.6 0.5 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase YfkB PF08756.10 VDK78764.1 - 0.039 13.8 0.3 0.27 11.0 0.0 2.6 2 0 0 2 2 2 0 YfkB-like domain Arr-ms PF12120.8 VDK78764.1 - 0.13 12.4 0.1 0.4 10.9 0.1 1.9 1 0 0 1 1 1 0 Rifampin ADP-ribosyl transferase Jnk-SapK_ap_N PF09744.9 VDK78764.1 - 3.6 7.8 33.0 0.73 10.0 15.5 2.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TSC22 PF01166.18 VDK78764.1 - 7.2 7.0 17.0 10 6.5 0.7 4.3 2 2 2 4 4 4 0 TSC-22/dip/bun family rRNA_processing PF08524.11 VDK78765.1 - 4.9e-12 46.1 16.4 5.9e-12 45.9 16.4 1.0 1 0 0 1 1 1 1 rRNA processing Meckelin PF09773.9 VDK78765.1 - 0.098 10.7 2.2 0.11 10.5 2.2 1.0 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) Rpr2 PF04032.16 VDK78766.1 - 6.2e-12 45.6 2.5 6.2e-12 45.6 2.5 1.5 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zinc_ribbon_15 PF17032.5 VDK78766.1 - 0.058 14.1 0.4 0.12 13.2 0.4 1.5 1 0 0 1 1 1 0 zinc-ribbon family DUF2072 PF09845.9 VDK78766.1 - 0.081 13.2 1.6 0.13 12.5 0.7 1.9 2 1 0 2 2 2 0 Zn-ribbon containing protein JAB PF01398.21 VDK78769.1 - 3.7e-32 110.8 0.9 1.8e-31 108.5 0.0 2.2 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 VDK78769.1 - 1.1e-31 109.6 0.2 2.1e-31 108.7 0.2 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Connexin PF00029.19 VDK78769.1 - 0.025 14.3 1.2 0.037 13.8 1.2 1.3 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 VDK78769.1 - 0.63 9.7 3.2 1.2 8.8 3.2 1.5 1 0 0 1 1 1 0 FAM176 family Atrophin-1 PF03154.15 VDK78769.1 - 7.7 4.7 6.8 10 4.3 6.8 1.1 1 0 0 1 1 1 0 Atrophin-1 family Hexokinase_1 PF00349.21 VDK78771.1 - 5.7e-73 245.1 0.0 7.3e-73 244.7 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 VDK78771.1 - 2.2e-49 168.1 0.0 3.4e-49 167.4 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Chromo PF00385.24 VDK78784.1 - 1.5e-14 53.6 0.4 4e-14 52.2 0.4 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 VDK78784.1 - 0.0081 16.0 0.1 0.022 14.6 0.1 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 VDK78784.1 - 0.073 13.3 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Polycomb-like MTF2 factor 2 Rubella_E2 PF05749.11 VDK78785.1 - 0.12 11.8 1.5 0.18 11.2 1.5 1.2 1 0 0 1 1 1 0 Rubella membrane glycoprotein E2 TMEM154 PF15102.6 VDK78785.1 - 0.99 9.3 7.4 1.7 8.6 7.4 1.4 1 0 0 1 1 1 0 TMEM154 protein family Cmc1 PF08583.10 VDK78787.1 - 5.8e-06 26.2 7.1 6.3e-06 26.1 6.3 1.5 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Jnk-SapK_ap_N PF09744.9 VDK78788.1 - 1e-49 168.8 20.3 1e-49 168.8 20.3 4.1 4 1 0 4 4 4 1 JNK_SAPK-associated protein-1 JIP_LZII PF16471.5 VDK78788.1 - 5.5e-31 106.6 10.5 5.5e-31 106.6 10.5 3.9 3 1 1 4 4 4 1 JNK-interacting protein leucine zipper II Atg14 PF10186.9 VDK78788.1 - 0.12 11.4 22.6 0.39 9.8 6.6 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5365 PF17326.2 VDK78788.1 - 0.52 10.7 2.6 1.6 9.2 2.6 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5365) DUF5093 PF17011.5 VDK78788.1 - 6.9 7.0 6.8 6.1 7.2 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5093) SMC_N PF02463.19 VDK78790.1 - 5.5e-67 225.4 4.5 9.3e-67 224.7 4.5 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 VDK78790.1 - 1.6e-20 73.6 0.0 5.4e-20 71.8 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain Pkinase PF00069.25 VDK78790.1 - 9.6e-17 61.2 5.1 1.9e-16 60.2 0.0 3.9 4 1 0 4 4 4 1 Protein kinase domain AAA_21 PF13304.6 VDK78790.1 - 8.4e-13 48.8 2.6 2.6e-05 24.2 0.0 3.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 VDK78790.1 - 1.9e-11 44.9 25.5 1.9e-11 44.9 25.5 7.2 2 2 2 4 4 4 1 AAA domain AAA_15 PF13175.6 VDK78790.1 - 1.4e-08 34.9 68.4 1.4e-05 25.0 26.9 4.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 VDK78790.1 - 0.0092 15.7 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain APH PF01636.23 VDK78790.1 - 0.36 10.7 0.0 0.36 10.7 0.0 2.7 3 0 0 3 3 3 0 Phosphotransferase enzyme family ABC_tran PF00005.27 VDK78790.1 - 4.7 7.7 0.0 4.7 7.7 0.0 6.2 3 2 0 4 4 4 0 ABC transporter Ras PF00071.22 VDK78795.1 - 1.3e-57 193.9 0.1 1.5e-57 193.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK78795.1 - 1.4e-21 76.9 0.0 2e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK78795.1 - 8.3e-10 38.4 0.0 9.4e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK78795.1 - 1.2e-05 25.3 0.0 0.041 13.8 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 VDK78795.1 - 6.1e-05 22.7 0.7 0.00038 20.0 0.2 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDK78795.1 - 0.00029 20.9 0.1 0.00042 20.4 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 VDK78795.1 - 0.0073 15.5 0.1 0.57 9.3 0.0 2.2 1 1 0 2 2 2 1 G-protein alpha subunit NTPase_1 PF03266.15 VDK78795.1 - 0.094 12.6 0.3 0.13 12.1 0.3 1.3 1 0 0 1 1 1 0 NTPase Ribosomal_L1 PF00687.21 VDK78796.1 - 1.6e-12 47.6 0.0 3.3e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family GTP_EFTU PF00009.27 VDK78797.1 - 2.9e-40 137.9 0.0 5.5e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 VDK78797.1 - 7.1e-27 93.9 5.4 6.4e-26 90.9 0.2 3.1 4 0 0 4 4 4 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 VDK78797.1 - 3.7e-08 33.6 1.8 5.9e-08 33.0 0.8 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 VDK78797.1 - 7.7e-05 22.7 0.0 0.00018 21.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK78797.1 - 0.04 13.5 0.0 0.08 12.5 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 VDK78797.1 - 0.055 13.4 0.1 0.89 9.4 0.1 2.2 1 1 1 2 2 2 0 RsgA GTPase SOBP PF15279.6 VDK78798.1 - 0.13 12.8 11.4 0.18 12.3 11.4 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein BtrH_N PF14399.6 VDK78798.1 - 0.14 12.4 0.8 0.26 11.5 0.8 1.5 1 0 0 1 1 1 0 Butirosin biosynthesis protein H, N-terminal Sel_put PF04328.13 VDK78798.1 - 4 7.5 11.9 2.2 8.4 0.2 3.7 4 0 0 4 4 4 0 Selenoprotein, putative Lin-8 PF03353.15 VDK78798.1 - 7.4 6.0 22.8 10 5.5 22.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PDDEXK_1 PF12705.7 VDK78799.1 - 3.3e-05 23.9 0.0 0.00028 20.9 0.0 2.0 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily MBT PF02820.18 VDK78801.1 - 1.4e-66 220.8 0.0 5.6e-21 74.7 0.0 4.3 4 0 0 4 4 4 4 mbt repeat DUF4131 PF13567.6 VDK78801.1 - 0.1 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Anth_Ig PF05587.13 VDK78801.1 - 0.19 12.0 0.0 0.5 10.7 0.0 1.6 1 0 0 1 1 1 0 Anthrax receptor extracellular domain ABC1 PF03109.16 VDK78802.1 - 7.4e-36 122.9 0.2 1.1e-35 122.3 0.2 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 VDK78802.1 - 0.00016 21.1 0.5 0.042 13.2 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain APH PF01636.23 VDK78802.1 - 0.00086 19.3 0.2 0.034 14.1 0.5 2.5 2 1 0 2 2 2 1 Phosphotransferase enzyme family UPF0240 PF06784.11 VDK78802.1 - 0.1 12.7 0.1 15 5.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0240) ApoO PF09769.9 VDK78804.1 - 0.02 14.8 1.6 1.8 8.6 0.3 3.1 2 1 1 3 3 3 0 Apolipoprotein O Abhydrolase_3 PF07859.13 VDK78806.1 - 2.8e-08 33.9 0.2 4e-08 33.4 0.2 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK78806.1 - 1.3e-05 24.6 0.0 3.2e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 VDK78806.1 - 0.0061 17.2 1.1 0.0081 16.8 1.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 VDK78806.1 - 0.01 15.4 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) LIDHydrolase PF10230.9 VDK78806.1 - 0.02 14.5 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Cutinase PF01083.22 VDK78806.1 - 0.047 13.7 0.0 0.38 10.7 0.0 2.0 1 1 0 2 2 2 0 Cutinase Abhydrolase_9_N PF15420.6 VDK78806.1 - 0.053 13.5 0.1 0.066 13.2 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Peptidase_S49_N PF08496.10 VDK78807.1 - 0.0043 17.1 1.0 0.0055 16.8 1.0 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal Tweety PF04906.13 VDK78807.1 - 0.075 11.7 0.3 0.097 11.3 0.3 1.2 1 0 0 1 1 1 0 Tweety B56 PF01603.20 VDK78808.1 - 7.9e-174 578.5 6.3 1.1e-173 578.0 6.3 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Not3 PF04065.15 VDK78823.1 - 1.5e-72 243.8 30.2 1.5e-72 243.8 30.2 2.0 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 VDK78826.1 - 6.8e-41 139.4 8.2 1.1e-40 138.7 8.2 1.4 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family SOBP PF15279.6 VDK78826.1 - 0.06 13.9 8.9 0.08 13.5 8.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein zf-RING_2 PF13639.6 VDK78829.1 - 4.9e-11 42.8 5.7 7.9e-11 42.1 5.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 VDK78829.1 - 2.4e-08 34.2 6.3 6.7e-08 32.7 6.3 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 VDK78829.1 - 3.7e-08 32.9 4.2 8.2e-08 31.9 4.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 VDK78829.1 - 7.9e-08 32.1 6.6 1.4e-07 31.2 6.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK78829.1 - 9.6e-08 31.8 6.8 1.6e-07 31.1 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK78829.1 - 1.4e-07 31.2 3.5 2.2e-07 30.7 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK78829.1 - 4.9e-07 29.7 3.3 8.8e-07 28.9 3.3 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 VDK78829.1 - 5.2e-06 26.3 5.1 8.4e-06 25.6 5.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 VDK78829.1 - 0.00015 21.7 3.7 0.00053 20.0 3.6 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 VDK78829.1 - 0.00089 18.8 4.0 0.0014 18.2 4.0 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Rtf2 PF04641.12 VDK78829.1 - 0.0014 18.1 1.3 0.0016 17.9 1.3 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 VDK78829.1 - 0.0025 17.9 5.3 0.0097 16.0 5.3 2.0 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 VDK78829.1 - 0.013 15.4 3.6 0.021 14.7 3.6 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 VDK78829.1 - 0.024 14.4 5.4 0.05 13.4 5.4 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 VDK78829.1 - 0.032 14.2 2.6 0.078 13.0 2.6 1.7 1 1 0 1 1 1 0 Zinc-finger RINGv PF12906.7 VDK78829.1 - 0.05 13.7 2.9 0.12 12.5 2.9 1.7 1 1 0 1 1 1 0 RING-variant domain DUF2951 PF11166.8 VDK78829.1 - 0.11 12.7 1.3 0.16 12.2 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) PHD PF00628.29 VDK78829.1 - 0.17 11.8 5.5 0.097 12.6 3.5 1.7 2 0 0 2 2 1 0 PHD-finger zf-RING-like PF08746.11 VDK78829.1 - 0.47 10.8 3.6 1.1 9.6 3.6 1.7 1 1 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 VDK78829.1 - 1.1 9.5 8.6 1.4 9.1 5.9 2.6 2 1 0 2 2 2 0 FANCL C-terminal domain C1_1 PF00130.22 VDK78829.1 - 1.4 8.8 7.0 2.4 8.1 4.8 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Metallophos PF00149.28 VDK78832.1 - 1.9e-29 103.6 0.0 3.1e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK78832.1 - 5.6e-08 33.1 0.0 1e-07 32.3 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain START PF01852.19 VDK78833.1 - 3.5e-31 108.2 0.0 5.2e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 START domain FRG1 PF06229.12 VDK78834.1 - 1.3e-60 204.4 0.1 1.7e-60 204.0 0.1 1.1 1 0 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 VDK78834.1 - 5.3e-05 23.4 0.0 0.00028 21.1 0.0 2.1 1 1 1 2 2 2 1 Fascin domain DUF1754 PF08555.10 VDK78834.1 - 0.017 15.9 2.6 0.017 15.9 2.6 2.2 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) MFS_1 PF07690.16 VDK78837.1 - 9.6e-36 123.4 44.5 8.2e-33 113.8 31.5 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 VDK78837.1 - 1.5e-12 47.2 11.5 1.5e-12 47.2 11.5 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 VDK78837.1 - 2e-10 39.6 29.2 2.2e-06 26.3 1.6 4.2 2 2 1 4 4 4 4 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 VDK78837.1 - 0.0023 16.6 11.1 0.0023 16.6 11.1 3.0 1 1 1 2 2 2 1 MFS/sugar transport protein Iron_permease PF04120.12 VDK78837.1 - 0.075 12.8 0.4 0.075 12.8 0.4 2.2 3 0 0 3 3 3 0 Low affinity iron permease YrhC PF14143.6 VDK78837.1 - 1.3 9.2 4.2 0.93 9.6 0.7 2.6 2 0 0 2 2 2 0 YrhC-like protein EMP70 PF02990.16 VDK78837.1 - 5.7 5.5 28.8 0.0092 14.7 3.8 3.7 2 1 2 4 4 4 0 Endomembrane protein 70 AAA_7 PF12775.7 VDK78839.1 - 0.00044 19.8 0.3 0.00094 18.7 0.3 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Vut_1 PF02592.15 VDK78839.1 - 0.043 14.2 0.5 0.077 13.3 0.5 1.4 1 0 0 1 1 1 0 Putative vitamin uptake transporter DUF4145 PF13643.6 VDK78839.1 - 0.12 12.5 0.1 2.2 8.5 0.1 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4145) Tubulin PF00091.25 VDK78840.1 - 7.7e-68 228.6 0.0 1e-67 228.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK78840.1 - 1.4e-49 167.4 0.0 2.9e-49 166.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK78840.1 - 0.00036 20.3 0.0 0.00076 19.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain DUF5567 PF17722.1 VDK78853.1 - 0.0086 16.0 0.2 0.011 15.6 0.2 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5567) DUF2512 PF10710.9 VDK78853.1 - 0.18 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2512) AbrB_C PF18277.1 VDK78853.1 - 0.51 10.0 2.8 11 5.7 0.0 2.7 2 1 1 3 3 3 0 AbrB C-terminal domain Homeodomain PF00046.29 VDK78854.1 - 1.1e-18 66.9 8.1 1.1e-18 66.9 8.1 1.7 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 VDK78854.1 - 0.00033 20.5 0.8 0.00033 20.5 0.8 1.9 2 0 0 2 2 2 1 Homeobox KN domain DUF5418 PF17439.2 VDK78864.1 - 0.045 13.8 1.0 3.8 7.6 0.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5418) Lactamase_B_6 PF16661.5 VDK78866.1 - 4.3e-57 192.7 0.0 2.2e-56 190.4 0.0 2.0 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 VDK78866.1 - 4.2e-37 127.9 0.1 1.4e-36 126.2 0.0 1.9 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 VDK78866.1 - 9.2e-21 74.2 0.0 2.8e-20 72.7 0.0 1.9 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 VDK78866.1 - 2.3e-13 49.9 0.0 5.2e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 VDK78866.1 - 1e-06 28.4 0.0 3e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 VDK78866.1 - 9.5e-05 22.5 0.0 0.00018 21.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily YedD PF13987.6 VDK78866.1 - 0.13 12.0 0.1 0.32 10.8 0.1 1.6 1 0 0 1 1 1 0 YedD-like protein WD40 PF00400.32 VDK78867.1 - 1.4e-42 142.9 13.2 1.3e-06 29.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat zf-NOSIP PF15906.5 VDK78867.1 - 1.6e-31 108.3 0.2 3.4e-31 107.2 0.2 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein ANAPC4_WD40 PF12894.7 VDK78867.1 - 5.4e-10 39.5 0.0 0.039 14.3 0.0 5.2 2 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK78867.1 - 3e-08 33.8 0.3 0.058 13.3 0.0 3.6 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 VDK78867.1 - 3.6e-06 26.2 0.8 0.16 10.9 0.0 3.7 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Rtf2 PF04641.12 VDK78867.1 - 8.2e-06 25.4 7.3 0.0047 16.3 0.1 2.8 2 1 1 3 3 3 2 Rtf2 RING-finger U-box PF04564.15 VDK78867.1 - 4.8e-05 23.5 0.0 0.00078 19.6 0.0 2.7 2 1 0 2 2 2 1 U-box domain Nup160 PF11715.8 VDK78867.1 - 0.00012 20.9 0.1 0.00041 19.1 0.0 1.8 2 0 0 2 2 2 1 Nucleoporin Nup120/160 zf-Nse PF11789.8 VDK78867.1 - 0.008 16.0 1.3 0.088 12.6 0.1 3.0 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit BPL_LplA_LipB PF03099.19 VDK78868.1 - 9.9e-07 28.7 0.0 6.1e-06 26.2 0.0 2.1 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Presenilin PF01080.17 VDK78870.1 - 5.3e-155 516.1 0.9 5.3e-155 516.1 0.9 2.0 2 0 0 2 2 2 1 Presenilin DUF4820 PF16091.5 VDK78870.1 - 0.14 11.5 0.7 0.23 10.8 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Fz PF01392.22 VDK78872.1 - 4.1e-05 24.2 1.9 4.1e-05 24.2 1.9 2.2 2 0 0 2 2 2 1 Fz domain 2Fe-2S_thioredx PF01257.19 VDK78874.1 - 2.9e-63 212.1 0.0 3.7e-63 211.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Sigma70_r4 PF04545.16 VDK78874.1 - 0.19 11.2 0.0 4.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 Collagen PF01391.18 VDK78875.1 - 5.8e-30 102.8 98.3 2.4e-10 40.0 31.7 4.1 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Ribosomal_S8e PF01201.22 VDK78877.1 - 2e-23 83.1 0.0 2.6e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e Metallophos PF00149.28 VDK78889.1 - 1.2e-37 130.4 0.1 1.6e-37 130.0 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK78889.1 - 6.6e-11 42.5 0.0 1.3e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain UBA_3 PF09288.10 VDK78889.1 - 0.071 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain PLU-1 PF08429.11 VDK78890.1 - 0.0087 15.3 1.4 0.02 14.1 1.4 1.6 1 0 0 1 1 1 1 PLU-1-like protein TFCD_C PF12612.8 VDK78890.1 - 5.8 6.7 6.3 4.5 7.1 0.3 3.4 3 0 0 3 3 3 0 Tubulin folding cofactor D C terminal Cpn60_TCP1 PF00118.24 VDK78892.1 - 5.4e-156 520.0 11.1 6.3e-156 519.8 11.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PTAC PF06130.12 VDK78892.1 - 0.085 13.0 0.2 0.28 11.4 0.2 1.9 1 0 0 1 1 1 0 Phosphate propanoyltransferase 7TM_GPCR_Srsx PF10320.9 VDK78893.1 - 6.4e-37 127.3 19.8 7.8e-37 127.0 19.8 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 VDK78893.1 - 2.7e-09 36.7 14.9 4.9e-09 35.9 14.9 1.4 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 VDK78893.1 - 0.0046 16.6 20.4 0.032 13.9 20.3 2.3 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx IRS PF02174.17 VDK78894.1 - 8.7e-21 73.7 0.3 1.6e-20 72.8 0.3 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) DnaJ_C PF01556.18 VDK78895.1 - 5.1e-43 146.7 0.1 6.8e-43 146.3 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 VDK78895.1 - 1.1e-28 99.2 5.1 2.1e-28 98.2 4.6 1.8 2 0 0 2 2 2 1 DnaJ domain RPT PF13446.6 VDK78895.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.7 1 1 0 1 1 1 0 A repeated domain in UCH-protein Peptidase_C1 PF00112.23 VDK78900.1 - 2e-45 155.5 6.0 3e-45 155.0 6.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 VDK78900.1 - 8.2e-08 32.6 0.2 1.9e-07 31.4 0.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) PFL-like PF02901.15 VDK78900.1 - 0.02 13.5 0.0 0.028 13.1 0.0 1.1 1 0 0 1 1 1 0 Pyruvate formate lyase-like Glutaminase PF04960.15 VDK78901.1 - 5.4e-87 291.6 0.0 2.4e-63 214.0 0.0 2.2 1 1 1 2 2 2 2 Glutaminase EF-hand_14 PF17959.1 VDK78901.1 - 1.9e-25 89.0 0.3 4.1e-25 87.9 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain Ank_5 PF13857.6 VDK78901.1 - 5e-07 29.9 0.0 1.7e-06 28.2 0.0 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK78901.1 - 8.4e-07 29.5 0.0 1.9e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK78901.1 - 7.9e-06 26.3 0.0 2.4e-05 24.8 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK78901.1 - 0.00043 20.5 0.0 0.0019 18.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 VDK78901.1 - 0.00046 20.5 0.0 0.0014 19.0 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat VD10_N PF08476.10 VDK78901.1 - 0.0071 16.0 0.5 0.019 14.7 0.5 1.7 1 0 0 1 1 1 1 Viral D10 N-terminal EF-hand_1 PF00036.32 VDK78910.1 - 1.7e-31 105.4 13.6 1.2e-07 30.8 0.8 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 VDK78910.1 - 2.8e-29 101.3 7.7 5.9e-15 55.5 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 VDK78910.1 - 2e-25 88.4 8.7 1.4e-11 44.1 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 VDK78910.1 - 7.5e-25 85.3 9.9 7.5e-07 28.4 0.2 4.7 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 VDK78910.1 - 5.2e-23 79.0 9.2 1.1e-05 25.0 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain SPARC_Ca_bdg PF10591.9 VDK78910.1 - 2.1e-11 44.2 0.3 0.0001 22.6 0.0 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 VDK78910.1 - 8.5e-10 38.5 7.9 0.00092 19.1 0.7 3.9 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 VDK78910.1 - 6.8e-06 26.9 0.5 0.005 17.7 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain EF-hand_9 PF14658.6 VDK78910.1 - 1.5e-05 25.2 0.7 0.061 13.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain UPF0154 PF03672.13 VDK78910.1 - 0.00013 21.9 0.0 0.4 10.7 0.0 2.4 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0154) Caleosin PF05042.13 VDK78910.1 - 0.0067 16.4 1.2 3.9 7.4 0.0 3.2 1 1 2 3 3 3 1 Caleosin related protein Dockerin_1 PF00404.18 VDK78910.1 - 0.013 15.7 8.9 0.88 9.8 0.7 3.7 1 1 3 4 4 4 0 Dockerin type I domain TPR_2 PF07719.17 VDK78913.1 - 6.3e-26 88.4 20.2 0.00039 20.3 0.1 7.9 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 VDK78913.1 - 6.5e-25 85.9 17.2 5.4e-06 26.0 0.1 7.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 VDK78913.1 - 1.3e-23 81.1 7.8 0.0011 19.0 0.0 7.9 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 VDK78913.1 - 1.1e-16 59.9 13.5 0.00097 19.4 0.1 7.7 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 VDK78913.1 - 7.8e-15 54.3 9.3 0.0033 18.1 0.1 7.0 5 1 2 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK78913.1 - 2.1e-13 49.7 12.6 0.0013 18.4 0.0 6.8 5 1 1 6 6 6 3 TPR repeat TPR_12 PF13424.6 VDK78913.1 - 3.6e-13 49.6 11.0 0.00059 20.1 0.0 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 VDK78913.1 - 2e-12 47.4 18.1 8.4e-05 23.0 0.2 5.7 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 VDK78913.1 - 2.4e-12 47.3 11.4 0.19 12.4 0.0 7.2 6 1 2 8 8 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 VDK78913.1 - 2.3e-10 40.5 5.9 0.013 15.6 0.1 6.5 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 VDK78913.1 - 1e-08 35.2 14.9 0.26 12.0 0.2 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK78913.1 - 1.8e-08 33.8 7.5 0.18 11.9 0.1 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 VDK78913.1 - 1.2e-06 28.2 13.0 0.013 15.4 0.3 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK78913.1 - 0.00035 20.7 16.2 0.094 13.0 0.3 4.9 5 1 0 6 6 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 VDK78913.1 - 0.00036 20.9 9.6 0.45 11.3 0.4 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat Rbsn PF11464.8 VDK78913.1 - 0.0011 18.6 0.5 1.8 8.3 0.0 2.7 2 0 0 2 2 2 2 Rabenosyn Rab binding domain TPR_15 PF13429.6 VDK78913.1 - 0.0027 17.0 7.8 0.048 12.9 2.2 4.0 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 VDK78913.1 - 0.0037 17.6 4.5 2.6 8.4 0.2 4.4 3 1 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 VDK78913.1 - 0.0062 16.6 0.0 0.16 12.1 0.0 3.0 1 1 0 1 1 1 1 Domain of Unknown Function (DUF3856) MIT PF04212.18 VDK78913.1 - 0.022 14.8 0.8 1.9 8.6 0.0 3.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain HrpB1_HrpK PF09613.10 VDK78913.1 - 0.024 14.3 2.8 0.32 10.6 0.1 3.2 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) PknG_TPR PF16918.5 VDK78913.1 - 0.037 12.8 2.6 1.5 7.5 0.0 3.2 2 1 1 3 3 3 0 Protein kinase G tetratricopeptide repeat BTAD PF03704.17 VDK78913.1 - 0.077 13.4 4.0 4.3 7.8 0.1 4.1 4 1 1 5 5 5 0 Bacterial transcriptional activator domain YqjK PF13997.6 VDK78913.1 - 0.29 11.4 1.1 78 3.6 0.2 3.7 3 0 0 3 3 3 0 YqjK-like protein CBP4 PF07960.11 VDK78913.1 - 0.46 10.3 5.0 1.7 8.5 1.2 2.8 3 0 0 3 3 3 0 CBP4 ANAPC5 PF12862.7 VDK78913.1 - 1.8 8.7 5.0 29 4.8 0.0 4.2 4 1 0 4 4 3 0 Anaphase-promoting complex subunit 5 Acetyltransf_18 PF18014.1 VDK78915.1 - 0.0021 17.9 0.1 1.5 8.6 0.1 3.2 3 1 0 3 3 3 1 Acetyltransferase (GNAT) domain PRA1 PF03208.19 VDK78918.1 - 6.1e-28 97.3 9.8 7.2e-28 97.0 9.8 1.0 1 0 0 1 1 1 1 PRA1 family protein Clc-like PF07062.12 VDK78918.1 - 1.1 8.7 10.5 2.1 7.7 10.4 1.5 1 1 0 1 1 1 0 Clc-like Pre-PUA PF17832.1 VDK78920.1 - 2.7e-21 76.0 0.1 7.1e-21 74.7 0.1 1.7 2 0 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 VDK78920.1 - 2.2e-16 59.5 0.3 5.7e-16 58.2 0.1 1.8 2 0 0 2 2 2 1 PUA domain WD40 PF00400.32 VDK78920.1 - 3.7e-13 49.7 16.9 0.0069 17.2 0.1 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK78920.1 - 0.00017 21.8 9.9 0.0022 18.2 0.8 4.4 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain APG6 PF04111.12 VDK78921.1 - 5.9e-59 199.0 0.1 9.6e-59 198.3 0.1 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 VDK78921.1 - 6.2e-21 75.3 20.5 1.2e-20 74.4 20.5 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region EIF4E-T PF10477.9 VDK78921.1 - 0.0059 15.5 0.6 0.008 15.1 0.6 1.1 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E FapA PF03961.13 VDK78921.1 - 0.81 8.2 8.9 0.89 8.1 7.7 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 VDK78921.1 - 5.2 7.8 10.9 27 5.5 7.6 3.1 1 1 1 2 2 2 0 Initiation control protein YabA Arf PF00025.21 VDK78923.1 - 1.5e-62 210.1 0.0 1.7e-62 209.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 VDK78923.1 - 8.7e-11 41.6 0.0 4.9e-08 32.5 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 VDK78923.1 - 3.8e-08 33.6 0.0 9.7e-08 32.3 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 VDK78923.1 - 3.4e-07 30.3 0.0 4.7e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 VDK78923.1 - 7e-07 28.9 0.0 8.7e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 VDK78923.1 - 1.8e-05 24.4 0.0 2e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 VDK78923.1 - 0.00065 19.1 0.0 0.00079 18.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region cobW PF02492.19 VDK78923.1 - 0.0021 17.7 0.0 0.11 12.1 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Neur_chan_LBD PF02931.23 VDK78927.1 - 0.00016 21.2 0.1 0.00022 20.8 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Ribosom_S12_S23 PF00164.25 VDK78928.1 - 7.6e-52 173.8 0.5 9.7e-52 173.4 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 RRM_7 PF16367.5 VDK78929.1 - 1.8e-23 82.4 0.0 8.8e-21 73.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif CEBP_ZZ PF16366.5 VDK78929.1 - 4.8e-17 62.0 5.7 4.8e-17 62.0 5.7 2.0 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 VDK78929.1 - 1.3e-16 60.1 0.0 4.2e-07 29.7 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_IE-1 PF05290.11 VDK78929.1 - 0.0076 16.2 0.5 0.018 15.0 0.4 1.6 2 0 0 2 2 2 1 Baculovirus immediate-early protein (IE-0) Coq4 PF05019.13 VDK78930.1 - 1.5e-83 279.5 0.0 1.8e-83 279.2 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 zf-DNL PF05180.12 VDK78930.1 - 5.8e-26 90.2 0.1 9.7e-26 89.5 0.1 1.4 1 0 0 1 1 1 1 DNL zinc finger zf-CSL PF05207.13 VDK78930.1 - 0.1 12.4 0.3 0.22 11.3 0.3 1.5 1 0 0 1 1 1 0 CSL zinc finger DUF2462 PF09495.10 VDK78932.1 - 6.1e-11 42.9 13.0 6.1e-11 42.9 13.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) IATP PF04568.12 VDK78935.1 - 5.7e-17 61.9 9.0 5.7e-17 61.9 9.0 2.0 1 1 1 2 2 2 1 Mitochondrial ATPase inhibitor, IATP EspA PF03433.13 VDK78935.1 - 0.031 14.1 0.5 0.036 13.9 0.5 1.1 1 0 0 1 1 1 0 EspA-like secreted protein FlxA PF14282.6 VDK78935.1 - 0.074 13.0 7.1 0.1 12.6 7.1 1.3 1 0 0 1 1 1 0 FlxA-like protein DUF4407 PF14362.6 VDK78935.1 - 0.18 11.1 3.7 0.2 11.0 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ntox15 PF15604.6 VDK78935.1 - 0.51 10.4 12.8 0.63 10.1 12.8 1.1 1 0 0 1 1 1 0 Novel toxin 15 DUF724 PF05266.14 VDK78935.1 - 0.72 9.7 11.6 0.91 9.3 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Lectin_N PF03954.14 VDK78935.1 - 1.2 8.9 4.0 1.6 8.5 4.0 1.2 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain IFT20 PF14931.6 VDK78935.1 - 3.6 7.8 16.1 4.4 7.5 16.1 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF3782 PF12644.7 VDK78935.1 - 4.4 7.5 9.7 16 5.7 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3782) Exonuc_VII_L PF02601.15 VDK78935.1 - 4.4 6.8 8.3 12 5.4 8.1 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Tho2 PF11262.8 VDK78935.1 - 4.5 6.4 9.1 5.6 6.1 9.1 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 PspB PF06667.12 VDK78935.1 - 6.1 7.0 7.2 7 6.8 6.4 1.4 1 1 0 1 1 1 0 Phage shock protein B Na_H_Exchanger PF00999.21 VDK78936.1 - 1.8e-58 198.2 28.6 1.8e-47 162.0 25.1 3.2 1 1 1 2 2 2 2 Sodium/hydrogen exchanger family DUF3995 PF13160.6 VDK78936.1 - 0.61 10.5 4.9 0.34 11.3 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3995) DUF2427 PF10348.9 VDK78936.1 - 1.8 8.4 6.4 4.8 7.0 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) BET PF17035.5 VDK78937.1 - 6.9e-23 80.6 0.0 2e-22 79.1 0.0 1.9 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Bromodomain PF00439.25 VDK78937.1 - 8.7e-21 73.8 1.3 1.2e-18 67.0 0.0 2.4 2 0 0 2 2 2 2 Bromodomain BRD4_CDT PF17105.5 VDK78937.1 - 3.1e-10 39.5 6.6 3.1e-10 39.5 6.6 2.9 2 0 0 2 2 2 1 C-terminal domain of bromodomain protein 4 ATS PF15445.6 VDK78937.1 - 0.027 13.9 7.9 0.045 13.2 7.9 1.3 1 0 0 1 1 1 0 acidic terminal segments, variant surface antigen of PfEMP1 Bromodomain PF00439.25 VDK78938.1 - 9.3e-12 44.9 0.0 1.4e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Bromodomain TIP49 PF06068.13 VDK78939.1 - 5.8e-154 512.5 2.6 7.1e-154 512.2 2.6 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 VDK78939.1 - 1.1e-19 70.4 0.1 6.5e-19 67.8 0.1 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 VDK78939.1 - 7.2e-10 39.4 1.0 6.9e-07 29.8 0.1 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK78939.1 - 3.2e-07 30.7 0.0 0.025 14.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 VDK78939.1 - 8.4e-07 29.4 0.8 6.5e-06 26.5 0.8 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK78939.1 - 1.4e-06 28.8 0.1 6.6e-06 26.6 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 VDK78939.1 - 6.1e-06 26.3 0.4 0.00034 20.6 0.0 3.1 3 1 0 3 3 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 VDK78939.1 - 1.6e-05 24.7 0.1 0.0025 17.6 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 VDK78939.1 - 0.00028 20.3 0.7 0.0037 16.7 0.3 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 VDK78939.1 - 0.00033 20.1 0.5 0.00052 19.4 0.5 1.3 1 0 0 1 1 1 1 KaiC Sigma54_activat PF00158.26 VDK78939.1 - 0.00035 20.3 0.1 0.013 15.2 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF2075 PF09848.9 VDK78939.1 - 0.00052 19.4 0.1 0.0036 16.6 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DnaB_C PF03796.15 VDK78939.1 - 0.00056 19.3 0.1 0.00097 18.5 0.1 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_7 PF12775.7 VDK78939.1 - 0.00079 19.0 0.1 0.0022 17.6 0.0 1.8 2 0 0 2 2 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 VDK78939.1 - 0.0017 18.1 0.5 0.079 12.7 0.2 2.3 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 VDK78939.1 - 0.0031 17.8 0.3 0.012 15.8 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 VDK78939.1 - 0.0041 17.6 1.5 0.16 12.4 0.4 2.9 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 VDK78939.1 - 0.0041 17.0 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 VDK78939.1 - 0.0051 16.4 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 VDK78939.1 - 0.0077 16.2 0.4 0.038 14.0 0.1 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 VDK78939.1 - 0.0092 16.5 0.2 0.11 13.0 0.3 2.3 2 1 0 2 2 2 1 AAA domain KTI12 PF08433.10 VDK78939.1 - 0.02 14.4 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 VDK78939.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PIF1 PF05970.14 VDK78939.1 - 0.044 13.0 0.4 2.7 7.1 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase ResIII PF04851.15 VDK78939.1 - 0.045 13.7 0.5 0.9 9.5 0.5 2.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit CPT PF07931.12 VDK78939.1 - 0.064 13.1 0.8 0.71 9.7 0.1 3.0 3 1 1 4 4 4 0 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 VDK78939.1 - 0.065 13.8 0.1 0.23 12.0 0.1 2.1 1 1 0 1 1 1 0 AAA domain EAP30 PF04157.16 VDK78939.1 - 0.066 12.5 0.1 4 6.7 0.0 2.5 2 0 0 2 2 2 0 EAP30/Vps36 family Sigma54_activ_2 PF14532.6 VDK78939.1 - 0.071 13.2 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 VDK78939.1 - 0.074 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 VDK78939.1 - 0.16 12.4 0.0 0.43 11.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 VDK78939.1 - 0.16 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain INT_SG_DDX_CT_C PF15300.6 VDK78940.1 - 0.028 14.2 0.3 0.084 12.7 0.3 1.8 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus CDC45 PF02724.14 VDK78956.1 - 4.9e-97 325.8 1.8 6.3e-85 285.8 0.4 3.0 1 1 1 2 2 2 2 CDC45-like protein Sin_N PF04801.13 VDK78958.1 - 5.7e-90 302.6 0.0 6.6e-90 302.4 0.0 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region DUF5452 PF17533.2 VDK78958.1 - 0.03 14.4 0.3 0.03 14.4 0.3 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5452) RRN3 PF05327.11 VDK78959.1 - 2.3e-81 274.0 5.6 2.4e-80 270.7 5.6 2.0 1 1 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF952 PF06108.12 VDK78959.1 - 0.024 14.7 0.0 0.25 11.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF952) PH_RBD PF12068.8 VDK78960.1 - 1.6e-40 138.3 3.1 2.8e-24 85.5 0.3 2.6 3 0 0 3 3 3 2 Rab-binding domain (RBD) RabGAP-TBC PF00566.18 VDK78960.1 - 3.8e-33 115.0 7.4 2.8e-32 112.1 1.7 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Selenoprotein_S PF06936.11 VDK78960.1 - 1.4 8.7 3.4 11 5.7 0.1 2.3 2 0 0 2 2 2 0 Selenoprotein S (SelS) RUN PF02759.19 VDK78961.1 - 1.2e-16 60.9 0.2 3.1e-16 59.6 0.2 1.6 1 1 0 1 1 1 1 RUN domain RecQ_Zn_bind PF16124.5 VDK78961.1 - 0.076 13.8 0.1 17 6.2 0.1 2.6 2 1 0 2 2 2 0 RecQ zinc-binding FH2 PF02181.23 VDK78962.1 - 5.8e-34 117.8 0.8 1.3e-33 116.7 0.5 1.7 1 1 0 1 1 1 1 Formin Homology 2 Domain zf-H2C2_5 PF13909.6 VDK78962.1 - 0.0034 17.1 0.6 0.0034 17.1 0.6 2.3 2 0 0 2 2 2 1 C2H2-type zinc-finger domain SK_channel PF03530.14 VDK78973.1 - 8.1e-33 112.8 0.2 8.1e-33 112.8 0.2 2.1 2 0 0 2 2 2 1 Calcium-activated SK potassium channel CaMBD PF02888.16 VDK78973.1 - 1.4e-26 92.5 2.1 1.4e-26 92.5 2.1 2.4 2 0 0 2 2 2 1 Calmodulin binding domain Ion_trans_2 PF07885.16 VDK78973.1 - 1.5e-13 50.5 4.8 5e-13 48.8 4.8 1.8 1 0 0 1 1 1 1 Ion channel Lig_chan PF00060.26 VDK78973.1 - 0.002 18.0 7.6 0.0081 16.0 5.5 2.4 1 1 1 2 2 2 1 Ligand-gated ion channel FUSC PF04632.12 VDK78973.1 - 0.0037 15.9 5.6 0.0099 14.5 5.6 1.6 1 1 0 1 1 1 1 Fusaric acid resistance protein family YlbD_coat PF14071.6 VDK78973.1 - 0.0056 16.9 6.5 0.011 16.0 6.5 1.4 1 0 0 1 1 1 1 Putative coat protein IRK PF01007.20 VDK78973.1 - 0.0061 16.4 2.1 0.019 14.8 2.1 1.8 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans PF00520.31 VDK78973.1 - 0.0096 15.2 3.4 0.0096 15.2 3.4 1.8 1 1 1 2 2 2 1 Ion transport protein Pkinase PF00069.25 VDK78983.1 - 1.9e-46 158.6 0.6 2.5e-46 158.2 0.6 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK78983.1 - 7e-28 97.6 0.1 1.1e-27 97.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.16 VDK78983.1 - 8.2e-09 35.4 0.0 2.3e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK78983.1 - 8.6e-06 26.3 0.0 2.1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin domain SH3_2 PF07653.17 VDK78983.1 - 0.0001 21.9 0.1 0.00033 20.3 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK78983.1 - 0.0017 17.9 0.1 0.033 13.8 0.0 2.9 3 0 0 3 3 3 1 SH3 domain Kinase-like PF14531.6 VDK78983.1 - 0.0044 16.4 0.0 0.007 15.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like ig PF00047.25 VDK78983.1 - 0.0044 17.2 0.1 0.011 15.9 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain SH3_3 PF08239.11 VDK78983.1 - 0.014 15.7 0.1 0.048 13.9 0.1 2.0 1 0 0 1 1 1 0 Bacterial SH3 domain WD40 PF00400.32 VDK78984.1 - 3.6e-31 106.7 10.1 1.3e-07 32.1 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK78984.1 - 8.1e-15 54.9 3.0 0.0016 18.7 0.1 5.4 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 VDK78984.1 - 6.3e-11 41.7 0.1 1.3e-10 40.7 0.1 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain Nup160 PF11715.8 VDK78984.1 - 6.5e-10 38.3 0.6 0.0015 17.3 0.2 4.0 2 1 3 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 VDK78984.1 - 7.5e-07 28.4 4.2 0.21 10.5 0.7 4.1 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 VDK78984.1 - 8.4e-06 25.8 1.0 1.1 9.1 0.0 3.9 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 VDK78984.1 - 0.00086 17.9 0.1 0.016 13.8 0.0 2.3 2 1 0 2 2 2 1 Cytochrome D1 heme domain DUF1513 PF07433.11 VDK78984.1 - 0.0068 15.5 0.1 1.8 7.6 0.0 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1513) PALB2_WD40 PF16756.5 VDK78984.1 - 0.016 14.1 0.4 1.3 7.8 0.1 2.8 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain FOP_dimer PF09398.10 VDK78984.1 - 0.14 12.4 0.1 0.45 10.8 0.1 1.8 1 0 0 1 1 1 0 FOP N terminal dimerisation domain CXCXC PF03128.14 VDK78984.1 - 0.17 12.4 0.7 0.42 11.2 0.7 1.7 1 0 0 1 1 1 0 CXCXC repeat PQQ_3 PF13570.6 VDK78984.1 - 0.19 12.3 0.5 3.5 8.2 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain Hira PF07569.11 VDK78984.1 - 0.23 11.2 5.3 7.8 6.2 0.1 3.4 3 1 1 4 4 4 0 TUP1-like enhancer of split GRASP55_65 PF04495.14 VDK78985.1 - 1.3e-72 242.6 0.0 1.2e-51 174.6 0.0 3.1 2 1 1 3 3 3 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 VDK78985.1 - 1.4e-07 31.8 0.0 0.0053 17.1 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK78985.1 - 3.3e-07 30.1 0.0 0.018 14.9 0.0 2.7 2 0 0 2 2 2 2 PDZ domain SMN PF06003.12 VDK78985.1 - 0.011 15.0 4.5 0.029 13.6 4.5 1.7 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) WD40 PF00400.32 VDK78986.1 - 4.1e-36 122.4 15.8 5e-08 33.5 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK78986.1 - 3.2e-09 37.0 0.5 0.041 14.2 0.1 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain MRPL52 PF18699.1 VDK78989.1 - 2.2e-27 95.1 0.2 3e-27 94.6 0.2 1.2 1 0 0 1 1 1 1 Mitoribosomal protein mL52 C4bp_oligo PF18453.1 VDK78989.1 - 0.017 15.3 5.0 0.029 14.6 5.0 1.4 1 0 0 1 1 1 0 Oligomerization domain of C4b-binding protein alpha DUF3882 PF07066.11 VDK78989.1 - 0.026 14.6 0.0 0.035 14.2 0.0 1.1 1 0 0 1 1 1 0 Lactococcus phage M3 protein TcpS PF17456.2 VDK78989.1 - 0.037 14.1 0.1 0.049 13.7 0.1 1.3 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S TPR_7 PF13176.6 VDK78989.1 - 0.16 12.1 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Y_phosphatase PF00102.27 VDK78991.1 - 3.9e-66 223.0 0.8 3.9e-66 223.0 0.8 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK78991.1 - 0.0075 16.1 0.2 0.0075 16.1 0.2 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain TNFR_c6 PF00020.18 VDK78993.1 - 0.61 10.5 9.4 3 8.3 0.7 2.8 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region LicD PF04991.13 VDK78994.1 - 2.3e-05 24.6 0.3 4.8e-05 23.6 0.3 1.6 1 0 0 1 1 1 1 LicD family APP_E2 PF12925.7 VDK78995.1 - 0.04 13.6 1.6 0.071 12.8 1.5 1.6 1 1 0 1 1 1 0 E2 domain of amyloid precursor protein Lyase_1 PF00206.20 VDK78997.1 - 1e-26 94.1 0.0 1.8e-26 93.3 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 VDK78997.1 - 4.7e-06 27.1 0.1 1.4e-05 25.5 0.1 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus ASL_C PF08328.11 VDK78997.1 - 0.018 15.2 1.7 0.026 14.6 0.4 1.9 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminal RRP7 PF12923.7 VDK78999.1 - 1.6e-29 102.4 8.7 1.6e-29 102.4 8.7 1.9 3 0 0 3 3 3 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF5093 PF17011.5 VDK78999.1 - 0.053 13.8 0.2 0.053 13.8 0.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5093) PrmA PF06325.13 VDK78999.1 - 0.059 12.8 0.3 0.1 12.0 0.3 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) zf-NPL4 PF05020.15 VDK78999.1 - 0.099 12.8 0.6 0.21 11.7 0.6 1.5 1 0 0 1 1 1 0 NPL4 family, putative zinc binding region GP24_25 PF17388.2 VDK78999.1 - 0.11 12.5 1.0 0.47 10.5 0.2 2.1 2 0 0 2 2 2 0 Tail assembly gene products 24 & 25 DER1 PF04511.15 VDK79008.1 - 6.1e-69 231.8 12.5 7e-69 231.6 12.5 1.0 1 0 0 1 1 1 1 Der1-like family zf-RING_2 PF13639.6 VDK79009.1 - 4.5 7.7 10.6 0.98 9.8 6.0 2.4 2 0 0 2 2 2 0 Ring finger domain Glyco_transf_92 PF01697.27 VDK79010.1 - 2.8e-38 132.1 0.0 4.9e-38 131.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 VDK79010.1 - 0.08 13.5 0.0 0.2 12.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferase family 2 Spectrin PF00435.21 VDK79011.1 - 9.6e-70 231.7 241.0 4.5e-12 46.4 1.4 28.9 21 5 8 30 30 30 21 Spectrin repeat GAS2 PF02187.17 VDK79011.1 - 4.3e-30 103.6 1.1 1.5e-29 101.9 1.1 2.1 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain FadA PF09403.10 VDK79011.1 - 0.017 15.6 0.5 0.017 15.6 0.5 13.7 15 1 1 16 16 16 0 Adhesion protein FadA EF-hand_7 PF13499.6 VDK79011.1 - 0.035 14.6 1.4 0.26 11.8 0.1 3.5 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_6 PF13405.6 VDK79011.1 - 0.049 13.6 0.2 21 5.4 0.1 3.1 2 0 0 2 2 2 0 EF-hand domain Mobilization_B PF17511.2 VDK79011.1 - 5.5 7.4 11.0 1.9 8.9 0.0 5.5 4 0 0 4 4 4 0 Mobilization protein B Plectin PF00681.20 VDK79013.1 - 2.3e-82 270.6 4.3 0.023 14.6 0.1 34.6 30 9 10 40 40 40 22 Plectin repeat Spectrin PF00435.21 VDK79013.1 - 3.3e-20 72.5 37.5 1.2e-05 25.7 1.5 8.7 7 1 0 8 8 8 6 Spectrin repeat SH3_10 PF17902.1 VDK79013.1 - 3.4e-18 65.5 0.0 1.3e-17 63.6 0.0 2.1 1 0 0 1 1 1 1 SH3 domain Spectrin_like PF18373.1 VDK79013.1 - 0.0061 16.6 0.1 0.0061 16.6 0.1 4.3 3 1 0 3 3 3 1 Spectrin like domain OCRE PF17780.1 VDK79013.1 - 0.1 12.7 0.0 6.8 6.8 0.0 3.8 3 0 0 3 3 3 0 OCRE domain LisH PF08513.11 VDK79022.1 - 0.032 14.2 0.2 0.19 11.8 0.0 2.5 2 0 0 2 2 2 0 LisH RICTOR_V PF14668.6 VDK79022.1 - 0.14 12.4 0.1 34 4.8 0.0 3.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 zf-RanBP PF00641.18 VDK79024.1 - 2.1e-12 46.1 31.4 3.4e-05 23.1 2.6 4.2 4 0 0 4 4 4 3 Zn-finger in Ran binding protein and others OTU PF02338.19 VDK79024.1 - 1.1e-08 35.6 0.0 2.1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease DZR PF12773.7 VDK79024.1 - 0.00061 19.8 17.4 0.084 12.9 0.6 2.8 2 1 0 2 2 2 2 Double zinc ribbon Ig_3 PF13927.6 VDK79025.1 - 7e-28 97.0 0.2 2.7e-08 34.3 0.0 5.2 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.25 VDK79025.1 - 2.1e-21 75.9 0.0 4.7e-08 33.1 0.2 4.7 4 0 0 4 4 4 4 Immunoglobulin domain I-set PF07679.16 VDK79025.1 - 2.9e-21 75.3 0.0 7.2e-07 29.2 0.0 4.8 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_2 PF13895.6 VDK79025.1 - 2.2e-15 56.7 0.0 0.0077 16.5 0.0 4.9 4 0 0 4 4 4 3 Immunoglobulin domain fn3 PF00041.21 VDK79025.1 - 4.8e-15 55.7 1.0 2.2e-06 27.9 0.0 2.8 2 0 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 VDK79025.1 - 8.7e-15 54.8 5.5 8.4e-05 22.7 0.2 6.4 6 2 0 6 6 6 3 Immunoglobulin V-set domain Ig_6 PF18452.1 VDK79025.1 - 3.3e-08 33.0 0.1 0.2 11.2 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_5 PF16681.5 VDK79025.1 - 0.00029 21.2 0.1 0.68 10.4 0.0 4.4 4 0 0 4 4 4 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 VDK79025.1 - 0.0012 19.0 0.3 2.6 8.4 0.0 3.9 4 0 0 4 4 3 1 T-cell surface glycoprotein CD3 delta chain V-set_CD47 PF08204.11 VDK79025.1 - 0.026 14.5 0.0 2.2 8.3 0.0 3.4 4 1 0 4 4 4 0 CD47 immunoglobulin-like domain Izumo-Ig PF16706.5 VDK79025.1 - 0.069 13.2 0.0 5.2 7.2 0.0 3.4 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain Pkinase_Tyr PF07714.17 VDK79026.1 - 5.6e-80 268.4 0.0 9.7e-80 267.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK79026.1 - 2.9e-40 138.3 0.0 6.6e-40 137.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 VDK79026.1 - 0.00055 19.3 0.0 0.0015 17.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like TIG PF01833.24 VDK79026.1 - 0.067 13.3 0.3 0.2 11.8 0.1 2.0 2 0 0 2 2 2 0 IPT/TIG domain Bromodomain PF00439.25 VDK79027.1 - 3.3e-15 55.9 0.0 9.2e-15 54.5 0.0 1.8 1 0 0 1 1 1 1 Bromodomain zf-B_box PF00643.24 VDK79027.1 - 0.004 17.3 6.4 0.004 17.3 6.4 7.5 8 1 0 8 8 8 1 B-box zinc finger Exostosin PF03016.15 VDK79033.1 - 3.9e-53 180.6 0.0 5.8e-53 180.1 0.0 1.3 1 0 0 1 1 1 1 Exostosin family Glyco_transf_64 PF09258.10 VDK79033.1 - 1.5e-17 63.7 0.0 2.7e-17 62.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 64 domain zf-H2C2_2 PF13465.6 VDK79034.1 - 5.2e-11 42.5 14.3 4.3e-05 23.7 0.6 3.8 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.7 VDK79034.1 - 0.0004 20.7 19.0 0.028 14.8 0.6 4.0 3 0 0 3 3 3 3 Zinc-finger of C2H2 type DUF4513 PF14983.6 VDK79034.1 - 0.00058 19.9 0.0 0.0015 18.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4513) zf-C2H2 PF00096.26 VDK79034.1 - 0.00061 20.1 24.1 0.003 17.9 1.5 4.3 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK79034.1 - 0.00067 20.3 22.2 0.088 13.7 1.1 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK79034.1 - 0.24 11.7 13.3 1 9.7 0.6 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 VDK79034.1 - 7.2 7.1 17.3 3.8 8.0 1.0 4.1 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 VDK79034.1 - 7.2 6.7 20.3 1.5 8.9 0.9 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger MOZART1 PF12554.8 VDK79040.1 - 0.12 12.2 0.2 0.23 11.2 0.2 1.4 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated ANAPC3 PF12895.7 VDK79041.1 - 3e-05 24.1 6.6 5.7e-05 23.3 5.5 2.1 2 0 0 2 2 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 VDK79041.1 - 0.0002 21.9 1.2 0.64 11.0 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK79041.1 - 0.00067 19.9 6.4 0.18 12.1 0.3 3.0 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 VDK79041.1 - 0.0022 17.3 0.1 0.079 12.2 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDK79041.1 - 0.0026 17.5 5.4 0.054 13.3 0.7 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK79041.1 - 0.0032 17.5 6.2 0.14 12.4 0.7 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK79041.1 - 0.0046 17.0 15.5 0.023 14.8 0.9 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK79041.1 - 0.0098 15.9 2.3 0.057 13.5 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK79041.1 - 0.023 15.2 0.5 1.7 9.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 VDK79041.1 - 0.088 13.5 0.3 3.6 8.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK79041.1 - 0.12 12.8 1.0 1.9 9.0 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK79041.1 - 0.14 12.8 0.7 3.1 8.6 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4796 PF16044.5 VDK79046.1 - 3.7e-31 108.2 0.8 4e-31 108.1 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) Ion_trans PF00520.31 VDK79046.1 - 2.3e-05 23.8 0.1 2.8e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Ion transport protein zf-H2C2_2 PF13465.6 VDK79047.1 - 8.6e-27 92.3 33.0 7.8e-07 29.2 0.2 7.4 7 0 0 7 7 7 5 Zinc-finger double domain zf-C2H2 PF00096.26 VDK79047.1 - 6.9e-22 76.6 47.4 6.4e-06 26.3 2.2 6.3 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK79047.1 - 1e-17 63.3 45.2 0.0023 18.6 1.7 6.4 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK79047.1 - 9.3e-11 41.7 32.0 0.0065 16.7 0.1 6.9 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK79047.1 - 6.4e-06 26.0 34.5 0.16 12.0 0.7 6.5 6 0 0 6 6 6 4 C2H2-type zinc finger zf-met PF12874.7 VDK79047.1 - 0.0001 22.5 32.1 0.13 12.7 0.2 6.0 6 0 0 6 6 6 3 Zinc-finger of C2H2 type zf-Di19 PF05605.12 VDK79047.1 - 0.00012 22.2 20.7 0.001 19.3 1.2 4.4 3 2 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding GAGA PF09237.11 VDK79047.1 - 0.00046 19.9 6.7 0.03 14.1 0.4 3.3 2 1 1 3 3 3 1 GAGA factor PyrI_C PF02748.15 VDK79047.1 - 0.01 15.7 17.1 0.016 15.1 0.1 5.0 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_8 PF15909.5 VDK79047.1 - 0.09 13.1 18.0 1.2 9.5 4.8 3.1 2 1 1 3 3 3 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 VDK79047.1 - 0.14 12.9 13.7 8 7.3 6.5 3.4 2 1 1 3 3 3 0 zinc-ribbon family DUF3268 PF11672.8 VDK79047.1 - 0.69 10.3 14.1 0.24 11.7 1.7 3.1 2 1 2 4 4 4 0 zinc-finger-containing domain zf-RING_11 PF17123.5 VDK79047.1 - 1.6 8.5 6.5 4.5 7.1 0.0 3.9 4 0 0 4 4 4 0 RING-like zinc finger Zn-C2H2_12 PF18112.1 VDK79047.1 - 2.2 8.8 13.2 0.9 10.1 1.1 4.7 4 0 0 4 4 4 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 VDK79047.1 - 2.5 8.5 23.6 5.6 7.4 0.4 5.0 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) C1_4 PF07975.12 VDK79047.1 - 4.4 7.6 24.8 8.1 6.8 4.6 4.8 1 1 5 6 6 6 0 TFIIH C1-like domain Cpn60_TCP1 PF00118.24 VDK79049.1 - 2.5e-156 521.1 10.2 2.8e-156 521.0 10.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Surp PF01805.20 VDK79050.1 - 4e-12 45.9 2.4 5e-12 45.6 0.4 2.3 2 0 0 2 2 2 1 Surp module CTD_bind PF04818.13 VDK79050.1 - 1.5e-11 44.9 2.1 2.8e-10 40.9 0.2 3.2 3 0 0 3 3 3 1 RNA polymerase II-binding domain. G-patch PF01585.23 VDK79050.1 - 1.3e-08 34.5 2.0 2.5e-08 33.7 2.0 1.5 1 0 0 1 1 1 1 G-patch domain Apt1 PF10351.9 VDK79050.1 - 0.013 14.4 16.4 0.022 13.6 16.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain TFIIF_alpha PF05793.12 VDK79050.1 - 1.3 7.5 19.1 2.3 6.7 19.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GREB1 PF15782.5 VDK79050.1 - 3.5 4.6 8.3 5.1 4.1 8.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SAPS PF04499.15 VDK79050.1 - 7.9 5.1 9.9 13 4.5 9.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein INTS5_C PF14838.6 VDK79057.1 - 1.6e-06 27.1 0.0 1.6e-06 27.1 0.0 1.0 1 0 0 1 1 1 1 Integrator complex subunit 5 C-terminus 2CSK_N PF08521.10 VDK79057.1 - 0.022 14.9 0.1 0.022 14.9 0.1 1.1 1 0 0 1 1 1 0 Two-component sensor kinase N-terminal DUF2807 PF10988.8 VDK79058.1 - 1.8 8.3 4.7 15 5.3 0.9 3.9 3 1 0 3 3 3 0 Putative auto-transporter adhesin, head GIN domain 7tm_1 PF00001.21 VDK79059.1 - 2.6e-13 49.9 2.3 3.1e-13 49.7 2.3 1.0 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7tm_4 PF13853.6 VDK79059.1 - 0.054 13.2 1.4 0.87 9.3 0.1 2.1 2 0 0 2 2 2 0 Olfactory receptor VGLL4 PF15245.6 VDK79059.1 - 0.22 11.6 5.4 0.13 12.3 3.0 1.7 1 1 1 2 2 2 0 Transcription cofactor vestigial-like protein 4 His_Me_b4a2 PF18275.1 VDK79059.1 - 1.6 8.9 3.9 5.8 7.1 2.0 2.2 2 0 0 2 2 2 0 His-Me finger endonuclease beta4-alpha2 domain Kunitz_BPTI PF00014.23 VDK79060.1 - 1.3e-06 28.5 4.4 3.5e-06 27.2 4.4 1.7 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain SecE PF00584.20 VDK79061.1 - 0.0023 17.8 0.1 0.0043 16.9 0.1 1.5 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex P-mevalo_kinase PF04275.14 VDK79063.1 - 1.2e-37 128.3 0.0 1.7e-37 127.8 0.0 1.2 1 0 0 1 1 1 1 Phosphomevalonate kinase AbbA_antirepres PF14156.6 VDK79065.1 - 0.12 12.2 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Antirepressor AbbA TSP_1 PF00090.19 VDK79066.1 - 0.081 13.2 9.8 0.19 12.0 9.8 1.7 1 0 0 1 1 1 0 Thrombospondin type 1 domain PTB PF08416.13 VDK79075.1 - 1.7e-15 57.4 0.0 6.6e-08 32.8 0.0 2.4 2 0 0 2 2 2 2 Phosphotyrosine-binding domain SH3_2 PF07653.17 VDK79075.1 - 2.5e-09 36.7 0.1 4.9e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK79075.1 - 1.1e-07 31.3 0.0 2.1e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK79075.1 - 1.1e-05 25.2 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.6 VDK79075.1 - 0.034 14.6 0.0 0.086 13.3 0.0 1.6 1 0 0 1 1 1 0 Helically-extended SH3 domain DUF1387 PF07139.11 VDK79075.1 - 0.25 11.0 7.6 0.09 12.5 3.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) I_LWEQ PF01608.17 VDK79075.1 - 3.9 7.7 10.3 16 5.7 4.7 2.2 2 0 0 2 2 2 0 I/LWEQ domain DUF4637 PF15470.6 VDK79075.1 - 4.1 7.1 5.9 20 4.9 3.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Sina PF03145.16 VDK79078.1 - 7.5 6.4 9.4 0.78 9.7 0.2 2.2 2 0 0 2 2 2 0 Seven in absentia protein family Oxysterol_BP PF01237.18 VDK79079.1 - 1.9e-63 214.5 0.7 3.2e-63 213.8 0.7 1.3 1 1 0 1 1 1 1 Oxysterol-binding protein Oxysterol_BP PF01237.18 VDK79080.1 - 1.9e-63 214.5 0.7 3.2e-63 213.8 0.7 1.3 1 1 0 1 1 1 1 Oxysterol-binding protein Sina PF03145.16 VDK79082.1 - 7.5 6.4 9.4 0.78 9.7 0.2 2.2 2 0 0 2 2 2 0 Seven in absentia protein family FH2 PF02181.23 VDK79088.1 - 5.7e-87 292.3 9.7 5.7e-87 292.3 9.7 1.7 1 1 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 VDK79088.1 - 1.5e-39 135.6 3.4 1.5e-39 135.6 3.4 3.1 4 0 0 4 4 4 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 VDK79088.1 - 1.2e-22 80.4 5.2 9.5e-22 77.5 0.5 2.5 2 0 0 2 2 2 2 Diaphanous GTPase-binding Domain DUF641 PF04859.12 VDK79088.1 - 1.2 9.5 6.9 12 6.3 0.1 3.2 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) EB PF01683.18 VDK79090.1 - 6.2e-21 74.4 62.1 2.3e-11 43.8 8.2 5.6 4 2 1 5 5 5 4 EB module EGF_3 PF12947.7 VDK79090.1 - 0.007 16.5 10.7 0.007 16.5 10.7 4.8 5 0 0 5 5 5 3 EGF domain Pkinase PF00069.25 VDK79092.1 - 8.1e-32 110.6 0.0 1.2e-23 83.8 0.0 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK79092.1 - 5.2e-16 58.7 0.0 8.9e-14 51.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 VDK79092.1 - 1.1e-07 31.5 0.0 4.7e-07 29.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like DUF3915 PF13054.6 VDK79092.1 - 0.016 15.2 0.1 0.039 13.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Kunitz_BPTI PF00014.23 VDK79093.1 - 3.2e-71 235.4 15.4 3.3e-18 65.7 0.2 4.3 4 0 0 4 4 4 4 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 VDK79093.1 - 2.6e-28 98.1 45.2 4.2e-09 36.6 5.2 5.9 4 1 1 5 5 5 4 Lustrin, cysteine-rich repeated domain Kunitz_BPTI PF00014.23 VDK79095.1 - 1.3e-125 409.6 65.8 1.1e-17 64.0 1.5 8.5 8 0 0 8 8 8 8 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 VDK79095.1 - 5.7e-45 151.5 89.9 4.7e-10 39.7 8.8 8.6 7 0 0 7 7 7 7 Lustrin, cysteine-rich repeated domain SAD_SRA PF02182.17 VDK79095.1 - 0.0033 17.1 0.7 27 4.4 0.0 5.0 6 0 0 6 6 6 1 SAD/SRA domain RRM_1 PF00076.22 VDK79096.1 - 6.6e-20 70.7 0.0 9e-20 70.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK79096.1 - 9.6e-07 28.8 0.0 1.8e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 VDK79096.1 - 3.4e-05 23.4 0.0 4.4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK79096.1 - 0.0092 15.8 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif PHM7_cyt PF14703.6 VDK79096.1 - 0.088 13.0 0.0 1 9.6 0.0 2.0 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter KorB_C PF06613.11 VDK79096.1 - 0.12 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 KorB C-terminal beta-barrel domain RRM_1 PF00076.22 VDK79097.1 - 7e-20 70.6 0.0 9.4e-20 70.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK79097.1 - 1.3e-06 28.4 0.0 2.2e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 VDK79097.1 - 9.2e-05 22.0 0.0 0.00012 21.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DbpA PF03880.15 VDK79097.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 DbpA RNA binding domain SET_assoc PF11767.8 VDK79097.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_occluded PF16842.5 VDK79097.1 - 0.14 12.0 0.0 0.26 11.2 0.0 1.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif SelP_N PF04592.14 VDK79098.1 - 3.9 6.8 12.0 4.7 6.5 12.0 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF148 PF02520.17 VDK79099.1 - 0.00035 20.6 2.7 0.00055 20.0 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF148 YlqD PF11068.8 VDK79099.1 - 0.09 13.2 2.2 0.19 12.1 0.1 1.9 1 1 1 2 2 2 0 YlqD protein Acetyltransf_9 PF13527.7 VDK79101.1 - 0.02 15.0 0.0 0.053 13.6 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Talin_middle PF09141.10 VDK79119.1 - 7e-48 162.7 27.0 2e-47 161.2 0.2 4.8 3 2 1 4 4 4 2 Talin, middle domain FERM_M PF00373.18 VDK79119.1 - 2.2e-28 99.0 0.1 2.2e-28 99.0 0.1 2.3 2 1 0 2 2 2 1 FERM central domain FERM_f0 PF16511.5 VDK79119.1 - 1.5e-27 95.7 0.3 2.1e-25 88.8 0.1 3.3 4 0 0 4 4 4 1 N-terminal or F0 domain of Talin-head FERM FERM_N PF09379.10 VDK79119.1 - 2e-19 69.3 0.2 2.2e-16 59.5 0.1 3.2 2 0 0 2 2 2 2 FERM N-terminal domain I_LWEQ PF01608.17 VDK79119.1 - 5.2e-10 39.8 41.4 4.1e-06 27.1 8.0 6.4 2 1 4 6 6 6 5 I/LWEQ domain IRS PF02174.17 VDK79119.1 - 1.4e-05 24.9 0.0 3.6e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 PTB domain (IRS-1 type) ACBP PF00887.19 VDK79119.1 - 0.007 16.6 1.0 0.025 14.8 0.0 2.4 2 0 0 2 2 2 1 Acyl CoA binding protein SipA_VBS PF17985.1 VDK79119.1 - 0.047 13.6 3.4 1.8 8.6 0.0 4.1 5 0 0 5 5 5 0 SipA vinculin binding site GldM_N PF12081.8 VDK79119.1 - 1.1 9.3 6.3 8.7 6.4 0.0 3.7 3 1 0 3 3 3 0 GldM N-terminal domain CheZ PF04344.13 VDK79119.1 - 8.5 6.2 15.8 0.64 9.9 5.9 3.5 2 1 2 4 4 4 0 Chemotaxis phosphatase, CheZ I_LWEQ PF01608.17 VDK79121.1 - 7.1e-45 153.0 13.4 7.1e-45 153.0 13.4 12.7 6 3 6 12 12 12 4 I/LWEQ domain VBS PF08913.10 VDK79121.1 - 4e-20 72.5 0.1 4e-20 72.5 0.1 10.2 10 3 2 12 12 12 3 Vinculin Binding Site Med28 PF11594.8 VDK79121.1 - 0.00019 21.5 3.0 0.0058 16.7 0.1 3.7 3 0 0 3 3 3 1 Mediator complex subunit 28 Phage_T7_Capsid PF05396.11 VDK79121.1 - 0.022 15.1 0.8 14 6.0 0.2 4.1 2 0 0 2 2 2 0 Phage T7 capsid assembly protein Trns_repr_metal PF02583.17 VDK79121.1 - 0.17 12.3 0.1 0.17 12.3 0.1 4.8 4 1 0 4 4 4 0 Metal-sensitive transcriptional repressor Ku_PK_bind PF08785.11 VDK79121.1 - 9.6 6.4 12.0 9.3 6.4 0.3 5.1 4 1 1 5 5 5 0 Ku C terminal domain like wnt PF00110.19 VDK79124.1 - 8.4e-66 222.7 26.7 2.4e-65 221.2 26.7 1.6 1 1 0 1 1 1 1 wnt family wnt PF00110.19 VDK79126.1 - 6.3e-31 108.1 0.7 8e-31 107.8 0.7 1.0 1 0 0 1 1 1 1 wnt family Phospho_p8 PF10195.9 VDK79128.1 - 3.4 8.2 8.5 7.9 7.1 0.1 4.0 4 0 0 4 4 4 0 DNA-binding nuclear phosphoprotein p8 PCI PF01399.27 VDK79131.1 - 1e-21 77.4 1.6 1.7e-21 76.7 0.3 2.1 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 VDK79131.1 - 0.0012 18.7 1.1 21 5.4 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK79131.1 - 0.014 16.1 0.5 20 6.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK79131.1 - 0.07 13.0 5.9 0.34 10.8 0.7 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 VDK79131.1 - 0.13 12.6 3.9 4.4 7.7 0.5 4.0 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 VDK79131.1 - 0.13 12.4 7.7 0.34 11.1 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN6_N PF18055.1 VDK79131.1 - 0.41 11.0 11.7 16 5.8 0.0 3.4 1 1 2 3 3 3 0 26S proteasome regulatory subunit RPN6 N-terminal domain C2 PF00168.30 VDK79132.1 - 2.3e-08 34.2 0.0 4e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain UQ_con PF00179.26 VDK79133.1 - 8.4e-09 35.2 0.0 7.2e-08 32.2 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK79133.1 - 0.0033 17.1 0.0 0.0086 15.8 0.0 1.8 2 0 0 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 VDK79133.1 - 0.0054 17.0 0.1 2.2 8.6 0.2 2.4 2 0 0 2 2 2 2 RWD domain Josephin PF02099.17 VDK79133.1 - 0.09 12.9 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Josephin Peptidase_M48_N PF16491.5 VDK79134.1 - 5.9e-61 205.5 5.5 5.9e-61 205.5 5.5 1.7 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 VDK79134.1 - 7.6e-45 153.1 0.0 1.2e-44 152.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 DUF986 PF06173.12 VDK79134.1 - 0.69 10.0 6.8 0.27 11.3 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF986) La PF05383.17 VDK79135.1 - 1.2e-19 70.1 0.0 2.8e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 La domain RRM_3 PF08777.11 VDK79135.1 - 1.4e-18 66.8 2.6 1.4e-18 66.8 2.6 3.6 3 1 0 3 3 3 1 RNA binding motif RRM_1 PF00076.22 VDK79135.1 - 7.2e-11 41.8 11.0 3.2e-09 36.5 1.2 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRO8NT PF08082.11 VDK79135.1 - 0.0065 16.4 0.5 0.0065 16.4 0.5 2.2 2 1 1 3 3 3 1 PRO8NT (NUC069), PrP8 N-terminal domain Nup35_RRM_2 PF14605.6 VDK79135.1 - 0.0094 15.9 0.1 0.18 11.8 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif BRAP2 PF07576.12 VDK79135.1 - 0.018 15.2 0.6 0.046 13.9 0.6 1.7 1 0 0 1 1 1 0 BRCA1-associated protein 2 SAM_3 PF18016.1 VDK79135.1 - 0.087 12.6 0.1 2.8 7.8 0.0 2.5 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) PHM7_cyt PF14703.6 VDK79135.1 - 8.3 6.6 15.8 1.1 9.4 0.8 3.6 3 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter API5 PF05918.11 VDK79143.1 - 0.37 9.5 2.1 0.41 9.4 2.1 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) GRP PF07172.11 VDK79143.1 - 0.96 10.2 17.5 1.3 9.7 17.5 1.2 1 0 0 1 1 1 0 Glycine rich protein family Pkinase PF00069.25 VDK79144.1 - 1.4e-60 204.9 0.0 3.7e-60 203.5 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK79144.1 - 7e-37 127.1 0.0 1.2e-36 126.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 VDK79144.1 - 2.8e-23 81.8 26.3 1.1e-11 44.6 7.9 3.6 3 0 0 3 3 3 3 Hr1 repeat Pkinase_C PF00433.24 VDK79144.1 - 4.3e-09 36.9 3.9 1.7e-08 35.1 3.9 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 VDK79144.1 - 1.2e-05 24.8 0.0 6.1e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 Kinase-like HAUS6_N PF14661.6 VDK79144.1 - 1.5 8.3 7.4 3.3 7.2 6.7 1.9 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus AAA_23 PF13476.6 VDK79144.1 - 1.6 9.2 9.8 2.1 8.8 7.8 2.2 2 0 0 2 2 2 0 AAA domain DUF4200 PF13863.6 VDK79144.1 - 6.9 7.1 16.2 0.49 10.8 6.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Mannosyl_trans4 PF15971.5 VDK79145.1 - 0.099 12.5 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 DolP-mannose mannosyltransferase 5TM-5TMR_LYT PF07694.12 VDK79145.1 - 0.15 11.5 1.4 0.21 11.1 1.4 1.1 1 0 0 1 1 1 0 5TMR of 5TMR-LYT Collagen PF01391.18 VDK79146.1 - 3.7e-19 68.2 104.7 1.2e-09 37.8 22.1 5.0 2 2 1 3 3 3 2 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK79146.1 - 1.7e-08 34.4 0.6 3.1e-08 33.6 0.6 1.4 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Patched PF02460.18 VDK79147.1 - 3.5e-101 339.7 11.2 4.9e-56 190.3 1.8 2.0 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK79147.1 - 4.8e-20 71.9 3.1 4.8e-20 71.9 3.1 3.3 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation TMEM100 PF16311.5 VDK79147.1 - 0.68 9.5 2.5 3 7.5 2.5 2.1 1 0 0 1 1 1 0 Transmembrane protein 100 IFT46_B_C PF12317.8 VDK79148.1 - 8.4e-76 254.4 0.1 1.1e-75 254.0 0.1 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal Troponin PF00992.20 VDK79152.1 - 0.00013 22.3 11.5 0.00013 22.3 11.5 4.6 3 2 1 4 4 4 1 Troponin Troponin PF00992.20 VDK79153.1 - 0.00013 22.3 11.5 0.00013 22.3 11.5 4.6 3 2 1 4 4 4 1 Troponin DUF1768 PF08719.11 VDK79156.1 - 1.1e-27 97.2 0.8 2.5e-16 60.4 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF1768) Annexin PF00191.20 VDK79156.1 - 0.043 13.9 0.0 0.082 13.0 0.0 1.4 1 0 0 1 1 1 0 Annexin LRR_8 PF13855.6 VDK79158.1 - 3.5e-40 135.6 30.4 2.6e-13 49.5 3.2 6.2 3 1 3 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 VDK79158.1 - 5.6e-23 80.6 25.1 6.4e-05 23.2 4.2 7.0 6 1 1 7 7 7 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDK79158.1 - 1.1e-12 47.8 10.7 0.00024 20.7 0.6 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.6 VDK79158.1 - 2.4e-09 37.2 8.5 1.8e-05 24.7 1.4 2.9 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) ig PF00047.25 VDK79158.1 - 0.0087 16.2 0.0 0.019 15.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 VDK79158.1 - 0.0096 16.5 0.0 0.021 15.4 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain LRR_6 PF13516.6 VDK79158.1 - 0.015 15.3 26.1 1.4 9.2 0.1 9.0 11 0 0 11 11 11 0 Leucine Rich repeat LRR_1 PF00560.33 VDK79158.1 - 1.5 9.7 39.8 2.4 9.0 0.3 9.7 11 1 1 12 12 12 0 Leucine Rich Repeat Wbp11 PF09429.10 VDK79159.1 - 6.8e-19 68.1 5.9 6.8e-19 68.1 5.9 2.7 2 1 1 3 3 3 1 WW domain binding protein 11 Med21 PF11221.8 VDK79159.1 - 0.33 11.2 8.4 3.8 7.7 1.8 2.9 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Beach PF02138.18 VDK79168.1 - 2.1e-124 414.4 1.5 2.3e-124 414.3 0.1 1.8 2 0 0 2 2 2 1 Beige/BEACH domain FYVE PF01363.21 VDK79168.1 - 1e-16 60.8 15.0 1e-16 60.8 15.0 2.1 2 0 0 2 2 2 1 FYVE zinc finger PH_BEACH PF14844.6 VDK79168.1 - 8.2e-13 48.3 0.1 2.3e-12 46.9 0.1 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 VDK79168.1 - 2.3e-08 34.6 10.0 0.0024 18.6 0.1 6.0 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF4704 PF15787.5 VDK79168.1 - 6.3e-06 25.6 1.6 3.7e-05 23.1 1.6 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4704) DUF4800 PF16057.5 VDK79168.1 - 0.00048 19.5 0.2 0.001 18.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) zf-RING_UBOX PF13445.6 VDK79168.1 - 5.6 7.1 10.5 18 5.4 10.5 2.0 1 0 0 1 1 1 0 RING-type zinc-finger UQ_con PF00179.26 VDK79169.1 - 9.5e-54 180.9 0.0 1.1e-53 180.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 VDK79169.1 - 0.017 15.4 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 VDK79169.1 - 0.03 14.0 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UEV PF05743.13 VDK79169.1 - 0.088 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 UEV domain MINDY_DUB PF04424.13 VDK79171.1 - 9.8e-35 119.1 0.0 2.3e-34 117.9 0.0 1.6 2 0 0 2 2 2 1 MINDY deubiquitinase HMD PF03201.16 VDK79171.1 - 0.036 14.3 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase ATG7_N PF16420.5 VDK79172.1 - 4.3e-57 194.0 0.0 1e-56 192.8 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 VDK79172.1 - 5.5e-43 147.1 0.0 8.4e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 VDK79172.1 - 0.0045 16.4 0.0 3.6 6.9 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain rRNA_methylase PF06962.12 VDK79172.1 - 0.051 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative rRNA methylase Shikimate_DH PF01488.20 VDK79172.1 - 0.07 13.2 0.0 0.48 10.5 0.0 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ubiquitin PF00240.23 VDK79175.1 - 7.9e-11 41.6 0.0 1.3e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 VDK79175.1 - 0.00088 19.7 0.0 0.0024 18.3 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain DUF5484 PF17583.2 VDK79175.1 - 0.027 14.1 0.1 0.048 13.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5484) Ubiquitin_4 PF18036.1 VDK79175.1 - 0.061 13.4 0.0 7.3 6.7 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain FNIP_M PF14637.6 VDK79177.1 - 3.2e-63 213.8 2.8 3.2e-63 213.8 1.2 1.8 2 0 0 2 2 2 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 VDK79177.1 - 1.1e-30 106.7 0.0 2.4e-30 105.6 0.0 1.5 1 0 0 1 1 1 1 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 VDK79177.1 - 0.044 14.8 5.6 0.86 10.6 0.2 3.0 2 1 1 3 3 3 0 Folliculin-interacting protein N-terminus HSP90 PF00183.18 VDK79179.1 - 1e-220 734.1 30.3 1.9e-220 733.2 30.3 1.3 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 VDK79179.1 - 3e-13 50.3 0.4 8.7e-13 48.8 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 VDK79179.1 - 1.5e-09 37.8 2.1 3.9e-09 36.5 0.0 2.6 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SieB PF14163.6 VDK79179.1 - 0.068 12.7 0.7 4.9 6.6 0.2 2.7 2 0 0 2 2 2 0 Super-infection exclusion protein B Mt_ATP-synt_B PF05405.14 VDK79179.1 - 1.2 8.8 12.8 0.052 13.2 3.5 3.0 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Peptidase_A22B PF04258.13 VDK79180.1 - 9.3e-87 291.1 2.4 2e-86 290.0 2.4 1.5 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 VDK79180.1 - 6.4e-07 29.1 3.3 1.4e-06 28.0 3.3 1.6 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease GATA PF00320.27 VDK79182.1 - 8.8e-13 47.6 7.5 8.8e-13 47.6 7.5 1.7 2 0 0 2 2 2 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 VDK79182.1 - 0.008 15.7 0.7 0.02 14.4 0.7 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Trm112p PF03966.16 VDK79182.1 - 0.14 12.8 0.1 0.66 10.6 0.0 2.2 2 0 0 2 2 2 0 Trm112p-like protein DUF4611 PF15387.6 VDK79182.1 - 0.25 11.6 4.7 1.4 9.2 0.4 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) bZIP_2 PF07716.15 VDK79182.1 - 3.1 8.0 6.1 19 5.4 0.0 3.3 3 0 0 3 3 3 0 Basic region leucine zipper PUA_2 PF14306.6 VDK79183.1 - 0.066 12.9 0.2 9.6 5.9 0.0 2.0 1 1 1 2 2 2 0 PUA-like domain SH3_9 PF14604.6 VDK79191.1 - 1.1e-25 89.3 0.2 4.6e-14 52.0 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 VDK79191.1 - 1.9e-21 75.4 0.0 8.5e-13 47.7 0.0 2.3 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 VDK79191.1 - 2.9e-16 58.9 0.0 3.7e-07 29.7 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain DUF5344 PF17279.2 VDK79192.1 - 0.052 14.1 0.0 0.065 13.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5344) PITH PF06201.13 VDK79193.1 - 1.7e-39 135.5 0.1 3.1e-39 134.6 0.1 1.4 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 VDK79193.1 - 7.9e-18 64.4 0.0 1.5e-17 63.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Sad1_UNC PF07738.13 VDK79193.1 - 0.00021 21.3 0.0 0.00031 20.8 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal OST3_OST6 PF04756.13 VDK79193.1 - 0.0011 18.3 0.0 0.002 17.6 0.0 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 VDK79193.1 - 0.0015 18.8 0.0 0.0044 17.3 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 VDK79193.1 - 0.0068 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 VDK79193.1 - 0.095 13.2 0.1 0.33 11.4 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain Vps51 PF08700.11 VDK79194.1 - 7.7e-08 32.3 0.3 2.9e-07 30.5 0.3 2.0 1 0 0 1 1 1 1 Vps51/Vps67 PhoU PF01895.19 VDK79194.1 - 0.83 10.2 2.9 2.5 8.6 0.3 2.9 3 0 0 3 3 3 0 PhoU domain PIG-U PF06728.13 VDK79195.1 - 6.4e-86 288.8 35.3 7.8e-86 288.5 35.3 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U zf-UBR PF02207.20 VDK79197.1 - 3.4e-13 49.5 12.2 3.4e-13 49.5 12.2 3.7 3 1 1 4 4 4 1 Putative zinc finger in N-recognin (UBR box) DUF2767 PF10965.8 VDK79197.1 - 0.25 11.3 1.2 1.4 8.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2767) DHHC PF01529.20 VDK79198.1 - 2e-35 121.8 11.5 2e-35 121.8 11.5 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Transglut_core3 PF13471.6 VDK79198.1 - 0.074 13.0 0.4 0.14 12.0 0.4 1.4 1 0 0 1 1 1 0 Transglutaminase-like superfamily Gaa1 PF04114.14 VDK79199.1 - 1.8e-76 258.2 1.7 2.4e-76 257.8 1.7 1.2 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component EF-hand_7 PF13499.6 VDK79201.1 - 4.8e-08 33.3 0.0 2.3e-05 24.7 0.0 1.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 VDK79201.1 - 0.00094 19.0 0.0 0.0028 17.5 0.0 1.8 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK79201.1 - 0.0096 15.8 0.0 0.21 11.6 0.0 2.9 4 0 0 4 4 4 1 EF-hand domain EF-hand_9 PF14658.6 VDK79201.1 - 0.16 12.3 0.0 0.54 10.6 0.0 1.9 1 1 1 2 2 2 0 EF-hand domain CagA PF03507.13 VDK79201.1 - 0.18 11.7 0.0 0.23 11.4 0.0 1.1 1 0 0 1 1 1 0 CagA exotoxin Hep_59 PF07052.11 VDK79202.1 - 7.2e-21 74.9 4.0 7.2e-21 74.9 4.0 1.8 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 UPF0767 PF15990.5 VDK79202.1 - 0.42 10.8 2.4 1.1 9.4 0.2 2.5 2 0 0 2 2 2 0 UPF0767 family RRM_1 PF00076.22 VDK79203.1 - 1e-39 134.1 0.0 7.5e-13 48.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK79203.1 - 2.8e-08 33.4 0.0 0.00055 19.5 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 VDK79203.1 - 1.1e-06 28.6 0.5 0.62 10.2 0.0 4.4 3 1 0 3 3 3 2 Limkain b1 RRM_occluded PF16842.5 VDK79203.1 - 0.00016 21.4 0.0 0.27 11.1 0.0 3.2 3 0 0 3 3 3 2 Occluded RNA-recognition motif DUF1509 PF07420.11 VDK79203.1 - 6.7 5.6 7.1 11 4.8 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Forkhead PF00250.18 VDK79204.1 - 0.00037 20.7 2.1 0.0031 17.7 0.4 2.7 1 1 2 3 3 3 2 Forkhead domain FGF PF00167.18 VDK79210.1 - 1.1e-06 28.8 0.7 1.3e-06 28.5 0.2 1.4 2 0 0 2 2 2 1 Fibroblast growth factor Ion_trans_2 PF07885.16 VDK79211.1 - 8.4e-11 41.7 7.9 5.3e-06 26.3 0.0 3.1 3 0 0 3 3 3 2 Ion channel Sec3_C PF09763.9 VDK79213.1 - 5.3e-108 362.3 12.1 9.8e-108 361.4 12.1 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 VDK79213.1 - 7.9e-18 64.4 0.3 2e-17 63.1 0.3 1.7 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH PH PF00169.29 VDK79213.1 - 0.011 16.2 0.1 0.036 14.6 0.1 1.8 1 0 0 1 1 1 0 PH domain PH_13 PF16652.5 VDK79213.1 - 0.068 13.0 0.2 0.17 11.7 0.2 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Acyltransferase PF01553.21 VDK79214.1 - 1.1e-06 28.3 0.0 2.3e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Coa1 PF08695.10 VDK79214.1 - 8.1e-06 25.6 0.0 1.7e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 DAGAT PF03982.13 VDK79214.1 - 0.00078 18.5 0.0 0.0013 17.7 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase zf-C2H2_jaz PF12171.8 VDK79215.1 - 2.6e-10 40.3 1.5 2.6e-10 40.3 1.5 2.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK79215.1 - 0.0045 17.3 0.8 0.0045 17.3 0.8 2.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type DUF1279 PF06916.13 VDK79216.1 - 8e-19 68.0 3.2 1.6e-18 67.0 3.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) PIG-P PF08510.12 VDK79216.1 - 0.0071 16.3 6.3 0.015 15.2 6.2 1.6 1 1 0 1 1 1 1 PIG-P TRAP-delta PF05404.12 VDK79217.1 - 5e-53 178.9 2.1 5.8e-53 178.7 2.1 1.0 1 0 0 1 1 1 1 Translocon-associated protein, delta subunit precursor (TRAP-delta) CN_hydrolase PF00795.22 VDK79219.1 - 2.9e-63 213.6 0.0 3.7e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HIT PF01230.23 VDK79219.1 - 5.8e-20 71.9 1.3 8.2e-20 71.4 0.2 1.8 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 VDK79219.1 - 9e-05 22.9 0.0 0.00021 21.7 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 VDK79219.1 - 0.13 12.1 0.0 0.35 10.7 0.0 1.7 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Glycos_transf_2 PF00535.26 VDK79220.1 - 1.6e-31 109.4 0.0 2.7e-31 108.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 VDK79220.1 - 2e-23 83.0 0.6 3.4e-23 82.3 0.6 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_2 PF10111.9 VDK79220.1 - 5.4e-08 32.7 0.0 4.8e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 VDK79220.1 - 4.4e-06 26.2 0.2 1.1e-05 25.0 0.2 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_3 PF13641.6 VDK79220.1 - 0.00015 21.7 0.0 0.00058 19.8 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 zf-C4 PF00105.18 VDK79221.1 - 5.8e-11 42.7 7.8 1.7e-10 41.2 7.8 1.9 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) DUF3403 PF11883.8 VDK79221.1 - 0.24 11.6 1.0 0.61 10.3 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3403) UDPGP PF01704.18 VDK79222.1 - 1.1e-35 123.1 0.0 1.4e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 VDK79222.1 - 0.026 14.9 0.0 0.045 14.1 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain DUF4123 PF13503.6 VDK79222.1 - 0.046 14.1 0.1 0.64 10.4 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4123) MlaC PF05494.12 VDK79222.1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 MlaC protein Mito_carr PF00153.27 VDK79223.1 - 2.3e-48 162.0 6.3 3.1e-18 65.5 0.1 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein THAP PF05485.12 VDK79234.1 - 0.00046 21.1 0.1 0.0011 19.9 0.1 1.6 1 0 0 1 1 1 1 THAP domain MazE_antitoxin PF04014.18 VDK79234.1 - 0.032 14.2 0.0 0.065 13.2 0.0 1.6 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin BLM10_mid PF16507.5 VDK79236.1 - 4.3e-68 230.2 10.4 1.7e-65 221.7 10.4 3.5 1 1 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 VDK79236.1 - 1.1e-34 118.2 0.0 3.8e-34 116.5 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) HEAT_EZ PF13513.6 VDK79236.1 - 0.00025 21.5 0.7 3.1 8.4 0.0 4.7 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 VDK79236.1 - 0.017 15.3 0.0 0.38 11.1 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat Arm PF00514.23 VDK79236.1 - 0.047 13.8 0.0 1.8 8.7 0.0 3.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Guanylate_kin PF00625.21 VDK79237.1 - 1.3e-46 158.6 0.0 2.1e-46 157.9 0.0 1.3 1 0 0 1 1 1 1 Guanylate kinase PDZ PF00595.24 VDK79237.1 - 1.4e-11 44.5 0.2 2.9e-11 43.6 0.2 1.5 1 0 0 1 1 1 1 PDZ domain SH3_2 PF07653.17 VDK79237.1 - 3.9e-09 36.1 0.0 9.1e-09 34.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK79237.1 - 2e-06 27.3 0.6 1.1e-05 24.9 0.6 2.3 1 1 0 1 1 1 1 SH3 domain PDZ_6 PF17820.1 VDK79237.1 - 4.2e-06 26.5 0.0 1.1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 PDZ domain SH3_9 PF14604.6 VDK79237.1 - 5.5e-05 22.9 0.0 0.00015 21.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain OATP PF03137.20 VDK79239.1 - 3.5e-91 306.2 16.4 2.7e-46 158.0 9.9 3.1 2 1 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family DUF2729 PF10870.8 VDK79239.1 - 0.019 14.8 0.6 0.061 13.2 0.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2729) Wzy_C PF04932.15 VDK79239.1 - 0.27 10.9 3.1 2 8.0 0.0 3.1 3 1 0 3 3 3 0 O-Antigen ligase Ank_2 PF12796.7 VDK79242.1 - 5.2e-48 161.5 19.0 4.9e-11 43.1 1.2 6.0 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK79242.1 - 1.6e-46 156.1 13.8 7.3e-09 36.0 0.6 9.4 4 3 6 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK79242.1 - 1.3e-28 95.9 19.0 0.0018 18.6 0.0 11.3 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 VDK79242.1 - 3.3e-27 94.2 16.2 9.2e-05 22.7 0.0 7.9 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 VDK79242.1 - 2.4e-20 72.0 26.2 0.003 17.9 0.2 11.0 11 0 0 11 11 11 8 Ankyrin repeat Ig_C17orf99 PF17736.1 VDK79242.1 - 0.032 14.3 0.3 8 6.6 0.0 2.8 2 0 0 2 2 2 0 C17orf99 Ig domain SAND PF01342.21 VDK79242.1 - 0.043 13.5 0.1 4.8 7.0 0.0 2.5 2 0 0 2 2 2 0 SAND domain DUF2520 PF10728.9 VDK79242.1 - 0.072 12.9 2.9 27 4.5 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF2520) TGF_beta PF00019.20 VDK79251.1 - 0.0081 17.1 2.5 0.016 16.2 2.5 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain FSH1 PF03959.13 VDK79253.1 - 1.4e-55 188.3 0.0 1.5e-55 188.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 VDK79253.1 - 3.4e-06 27.0 0.0 1.2e-05 25.3 0.0 1.9 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 VDK79253.1 - 0.0027 17.0 0.0 0.089 12.0 0.0 2.4 2 1 1 3 3 3 1 Serine aminopeptidase, S33 DLH PF01738.18 VDK79253.1 - 0.0048 16.5 0.0 0.0065 16.0 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 VDK79253.1 - 0.013 15.1 0.0 2.6 7.6 0.0 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold Thioesterase PF00975.20 VDK79253.1 - 0.021 15.0 0.0 0.33 11.0 0.0 2.4 2 1 0 2 2 2 0 Thioesterase domain Abhydrolase_4 PF08386.10 VDK79253.1 - 0.022 14.9 0.3 0.078 13.1 0.0 1.9 2 1 1 3 3 3 0 TAP-like protein BAAT_C PF08840.11 VDK79253.1 - 0.056 13.4 0.0 0.28 11.1 0.0 1.7 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal MTS PF05175.14 VDK79254.1 - 0.0031 17.1 0.0 0.54 9.8 0.0 3.1 1 1 1 2 2 2 1 Methyltransferase small domain CmcI PF04989.12 VDK79254.1 - 0.053 13.2 0.0 0.087 12.5 0.0 1.2 1 0 0 1 1 1 0 Cephalosporin hydroxylase TIR-like PF10137.9 VDK79254.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Predicted nucleotide-binding protein containing TIR-like domain Methyltransf_23 PF13489.6 VDK79254.1 - 0.19 11.5 0.0 2 8.2 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Membralin PF09746.9 VDK79255.1 - 2.8e-157 523.6 4.5 3.6e-157 523.3 4.5 1.1 1 0 0 1 1 1 1 Tumour-associated protein Collagen PF01391.18 VDK79258.1 - 9.6e-26 89.3 107.1 1.4e-10 40.7 38.4 4.1 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK79258.1 - 9.3e-14 51.2 1.4 1.3e-13 50.8 1.4 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Hemocyanin_C PF03723.14 VDK79258.1 - 0.25 10.6 0.0 0.34 10.2 0.0 1.1 1 0 0 1 1 1 0 Hemocyanin, ig-like domain Ran_BP1 PF00638.18 VDK79259.1 - 5.1e-12 46.1 0.1 1.6e-11 44.6 0.0 1.9 2 0 0 2 2 2 1 RanBP1 domain WH1 PF00568.23 VDK79259.1 - 0.0019 18.1 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 WH1 domain SGT1 PF07093.11 VDK79259.1 - 4.4 5.6 9.0 6.3 5.1 9.0 1.1 1 0 0 1 1 1 0 SGT1 protein EF-hand_1 PF00036.32 VDK79260.1 - 1.1e-11 43.3 12.6 8e-07 28.2 1.9 3.7 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 VDK79260.1 - 3.8e-10 38.9 9.9 1.2e-06 27.9 0.9 4.1 4 0 0 4 4 4 2 EF-hand domain 4HBT PF03061.22 VDK79260.1 - 3.8e-10 40.0 0.0 6.6e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily EF-hand_7 PF13499.6 VDK79260.1 - 2.2e-08 34.4 1.9 2.2e-08 34.4 1.9 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK79260.1 - 3.3e-08 32.7 4.5 0.00064 19.1 0.3 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 VDK79260.1 - 5.2e-06 26.2 2.1 0.042 13.7 0.5 2.7 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 VDK79260.1 - 0.00041 20.6 0.3 0.00041 20.6 0.3 2.4 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 VDK79260.1 - 0.009 15.9 1.8 1.3 8.9 1.5 2.6 1 1 1 2 2 2 1 Caleosin related protein Tombus_P33 PF08500.10 VDK79260.1 - 0.1 12.6 0.5 0.37 10.8 0.5 2.0 1 0 0 1 1 1 0 Tombusvirus p33 PRIMA1 PF16101.5 VDK79260.1 - 0.16 12.0 11.4 0.19 11.8 4.7 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 FAM184 PF15665.5 VDK79271.1 - 4.4e-32 111.6 25.3 4.4e-32 111.6 25.3 1.6 2 0 0 2 2 2 1 Family with sequence similarity 184, A and B Integrase_DNA PF02920.15 VDK79271.1 - 0.89 9.3 7.5 0.096 12.4 1.1 2.6 2 0 0 2 2 2 0 DNA binding domain of tn916 integrase LMBR1 PF04791.16 VDK79271.1 - 1.3 7.8 10.7 1.7 7.5 10.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ARGLU PF15346.6 VDK79271.1 - 4 7.3 34.2 1.2 9.0 3.3 2.5 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 DUF4407 PF14362.6 VDK79271.1 - 6.4 6.0 14.9 8.2 5.7 6.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 VDK79271.1 - 7.7 6.7 14.6 0.65 10.2 4.4 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FAM184 PF15665.5 VDK79273.1 - 4.4e-32 111.6 25.3 4.4e-32 111.6 25.3 1.6 2 0 0 2 2 2 1 Family with sequence similarity 184, A and B Integrase_DNA PF02920.15 VDK79273.1 - 0.89 9.3 7.5 0.096 12.4 1.1 2.6 2 0 0 2 2 2 0 DNA binding domain of tn916 integrase LMBR1 PF04791.16 VDK79273.1 - 1.3 7.8 10.7 1.7 7.5 10.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ARGLU PF15346.6 VDK79273.1 - 4 7.3 34.2 1.2 9.0 3.3 2.5 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 DUF4407 PF14362.6 VDK79273.1 - 6.4 6.0 14.9 8.2 5.7 6.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 VDK79273.1 - 7.7 6.7 14.6 0.65 10.2 4.4 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DM13 PF10517.9 VDK79276.1 - 3.4e-08 34.0 0.0 3.1e-07 30.9 0.0 2.5 2 0 0 2 2 2 1 Electron transfer DM13 Troponin PF00992.20 VDK79278.1 - 4.9e-42 143.4 16.3 4.9e-42 143.4 16.3 3.2 3 1 0 3 3 3 1 Troponin Arc_PepC_II PF06847.11 VDK79278.1 - 0.27 11.8 0.3 0.27 11.8 0.3 2.8 2 2 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II NOA36 PF06524.12 VDK79278.1 - 4.2 6.6 20.8 0.02 14.2 10.2 2.1 2 0 0 2 2 2 0 NOA36 protein Syntaxin PF00804.25 VDK79280.1 - 3.2e-28 98.8 7.4 3.2e-28 98.8 7.4 1.8 3 0 0 3 3 3 1 Syntaxin SNARE PF05739.19 VDK79280.1 - 3.2e-11 43.0 3.3 3.2e-11 43.0 3.3 2.1 2 0 0 2 2 2 1 SNARE domain Baculo_PEP_C PF04513.12 VDK79280.1 - 0.0036 17.3 15.5 0.021 14.9 1.1 3.3 3 0 0 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus H-kinase_dim PF02895.14 VDK79280.1 - 0.028 14.8 0.1 0.18 12.2 0.0 2.6 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain EVI2A PF05399.11 VDK79280.1 - 0.062 12.9 2.7 0.04 13.5 0.7 1.7 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) MCPsignal PF00015.21 VDK79280.1 - 0.16 11.8 2.7 11 5.8 0.1 2.5 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Mt_ATP-synt_B PF05405.14 VDK79280.1 - 0.18 11.4 15.2 0.42 10.2 1.0 3.6 2 1 1 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GIT1_C PF12205.8 VDK79280.1 - 0.42 10.7 5.9 3.9 7.6 0.0 3.4 3 1 0 3 3 3 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF3107 PF11305.8 VDK79280.1 - 0.98 9.7 5.7 0.94 9.8 0.3 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3107) Synaptobrevin PF00957.21 VDK79280.1 - 1.7 8.5 7.5 0.18 11.6 1.0 2.6 2 1 0 2 2 2 0 Synaptobrevin TACC_C PF05010.14 VDK79280.1 - 1.8 8.3 18.4 0.24 11.2 4.0 2.4 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal LPP PF04728.13 VDK79280.1 - 4.7 7.7 9.8 38 4.8 0.1 4.7 3 1 1 4 4 4 0 Lipoprotein leucine-zipper NPV_P10 PF05531.12 VDK79280.1 - 4.8 7.7 9.4 7.5 7.1 0.3 3.9 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein PAS_11 PF14598.6 VDK79282.1 - 1.7e-25 89.3 0.1 2.3e-21 76.0 0.0 2.4 2 0 0 2 2 2 2 PAS domain HLH PF00010.26 VDK79282.1 - 4.3e-13 49.0 0.7 8.7e-13 48.0 0.7 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PAS PF00989.25 VDK79282.1 - 3.6e-06 26.9 0.1 0.044 13.8 0.0 3.0 3 1 0 3 3 3 2 PAS fold PAS_3 PF08447.12 VDK79282.1 - 6.8e-06 26.3 0.1 0.0081 16.4 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 VDK79282.1 - 0.0096 16.2 0.0 3.9 7.8 0.0 2.6 2 1 0 2 2 2 2 PAS domain HSF_DNA-bind PF00447.17 VDK79282.1 - 0.053 14.1 0.0 0.15 12.7 0.0 1.8 1 0 0 1 1 1 0 HSF-type DNA-binding Innexin PF00876.18 VDK79283.1 - 7.1e-117 390.6 12.2 8.1e-117 390.4 12.2 1.0 1 0 0 1 1 1 1 Innexin Ribosomal_L37 PF08561.10 VDK79283.1 - 0.12 12.8 0.1 0.19 12.3 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 TPR_19 PF14559.6 VDK79284.1 - 0.0062 17.0 0.2 0.056 14.0 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat API5 PF05918.11 VDK79285.1 - 1.7e-67 228.4 12.1 3e-67 227.6 12.1 1.4 1 1 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) HEAT_2 PF13646.6 VDK79285.1 - 0.0083 16.5 0.3 0.062 13.7 0.1 2.3 1 1 1 2 2 2 1 HEAT repeats Ku_N PF03731.15 VDK79285.1 - 0.018 14.8 0.7 0.067 12.9 0.1 2.1 2 0 0 2 2 2 0 Ku70/Ku80 N-terminal alpha/beta domain RUN PF02759.19 VDK79286.1 - 1.1e-13 51.3 0.1 1.1e-13 51.3 0.1 3.0 2 2 0 2 2 2 1 RUN domain FYVE PF01363.21 VDK79286.1 - 4e-07 30.1 2.0 1.1e-06 28.6 2.0 1.7 1 0 0 1 1 1 1 FYVE zinc finger SAP PF02037.27 VDK79286.1 - 0.36 10.6 10.0 2.5 8.0 0.7 3.5 4 0 0 4 4 4 0 SAP domain FUSC PF04632.12 VDK79286.1 - 0.95 7.9 2.9 1.3 7.4 2.9 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family NPV_P10 PF05531.12 VDK79286.1 - 7.7 7.1 11.8 6.3 7.4 0.7 4.5 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 VDK79286.1 - 7.7 6.7 29.8 20 5.3 15.6 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 VDK79286.1 - 9.9 5.4 12.0 20 4.4 12.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HA2 PF04408.23 VDK79294.1 - 2.7e-15 56.6 0.0 2.7e-15 56.6 0.0 2.8 2 1 0 2 2 1 1 Helicase associated domain (HA2) R3H PF01424.22 VDK79294.1 - 1.8e-13 50.2 0.2 3e-12 46.3 0.0 2.6 2 0 0 2 2 2 1 R3H domain Helicase_C PF00271.31 VDK79294.1 - 2.1e-11 44.1 0.1 1.2e-10 41.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK79294.1 - 1.9e-10 40.8 0.2 3.5e-10 39.9 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 VDK79294.1 - 0.00093 19.6 0.2 0.002 18.5 0.2 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 VDK79294.1 - 0.001 18.5 0.0 0.0024 17.3 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 VDK79294.1 - 0.0017 18.6 0.2 0.0057 16.9 0.2 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 VDK79294.1 - 0.0049 16.6 0.0 0.0091 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 VDK79294.1 - 0.011 15.7 0.1 0.085 12.9 0.1 2.5 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 VDK79294.1 - 0.027 14.4 1.5 0.67 9.9 1.1 3.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit T2SSE PF00437.20 VDK79294.1 - 0.039 13.0 0.0 0.085 11.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Takusan PF04822.13 VDK79294.1 - 0.057 13.3 0.8 0.16 11.8 0.8 1.8 1 0 0 1 1 1 0 Takusan AAA_25 PF13481.6 VDK79294.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 VDK79294.1 - 0.16 11.4 0.0 0.31 10.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein EOS1 PF12326.8 VDK79294.1 - 0.36 10.7 2.6 1.2 9.1 2.6 1.8 1 0 0 1 1 1 0 N-glycosylation protein AAA_23 PF13476.6 VDK79294.1 - 0.52 10.8 0.0 0.52 10.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain SLC12 PF03522.15 VDK79296.1 - 6.1e-121 404.4 0.0 1.3e-120 403.3 0.0 1.5 1 0 0 1 1 1 1 Solute carrier family 12 Homeodomain PF00046.29 VDK79296.1 - 7.8e-23 80.1 11.0 1.2e-21 76.3 8.1 2.6 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 VDK79296.1 - 0.018 14.9 0.1 0.062 13.2 0.1 1.9 1 0 0 1 1 1 0 Homeobox KN domain MAGE_N PF12440.8 VDK79296.1 - 1.5 9.5 10.8 4.2 8.1 10.8 1.7 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal Motile_Sperm PF00635.26 VDK79297.1 - 6e-08 32.5 0.0 2.8e-06 27.1 0.0 2.4 2 0 0 2 2 2 1 MSP (Major sperm protein) domain FapA PF03961.13 VDK79297.1 - 0.015 13.9 7.3 0.018 13.6 7.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A I_LWEQ PF01608.17 VDK79297.1 - 0.059 13.6 6.6 0.12 12.6 6.6 1.5 1 0 0 1 1 1 0 I/LWEQ domain LktC PF06261.11 VDK79297.1 - 0.09 12.7 0.9 0.88 9.5 0.0 2.2 2 0 0 2 2 2 0 Actinobacillus actinomycetemcomitans leukotoxin activator LktC TolA_bind_tri PF16331.5 VDK79297.1 - 0.2 11.8 9.1 1.4 9.1 9.0 2.2 1 1 0 1 1 1 0 TolA binding protein trimerisation Atg14 PF10186.9 VDK79297.1 - 0.91 8.6 12.0 1.2 8.1 12.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SpmSyn_N PF17950.1 VDK79297.1 - 2.6 8.3 5.6 1.4 9.1 0.8 2.8 2 1 0 2 2 2 0 S-adenosylmethionine decarboxylase N -terminal AF-4 PF05110.13 VDK79300.1 - 0.014 13.6 14.8 0.016 13.3 14.8 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Vps55 PF04133.14 VDK79300.1 - 0.075 13.0 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting 55 DUF1180 PF06679.12 VDK79300.1 - 0.075 13.4 0.3 0.11 12.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) MLANA PF14991.6 VDK79300.1 - 0.4 11.0 5.0 0.15 12.3 0.7 2.3 1 1 2 3 3 3 0 Protein melan-A Ndc1_Nup PF09531.10 VDK79300.1 - 2.1 6.9 5.1 2.7 6.6 5.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pkinase PF00069.25 VDK79301.1 - 2.7e-25 89.2 0.0 3.4e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK79301.1 - 8.1e-15 54.8 0.0 1.1e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK79301.1 - 2e-05 24.6 0.0 0.045 13.7 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 VDK79301.1 - 7.9e-05 21.6 0.0 0.00011 21.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK79301.1 - 0.033 13.6 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SH2 PF00017.24 VDK79303.1 - 1.8e-10 40.7 0.4 3.1e-10 40.0 0.4 1.4 1 0 0 1 1 1 1 SH2 domain BTB_3 PF16017.5 VDK79309.1 - 1.7e-43 147.0 0.0 2.9e-43 146.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 VDK79309.1 - 0.0033 17.7 0.0 0.0079 16.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain LIM PF00412.22 VDK79311.1 - 7.9e-26 90.1 16.1 3.1e-13 49.7 5.6 2.1 2 0 0 2 2 2 2 LIM domain zf-RRN7 PF11781.8 VDK79311.1 - 0.0073 16.0 0.9 0.0073 16.0 0.9 2.9 4 0 0 4 4 4 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Yippee-Mis18 PF03226.14 VDK79311.1 - 0.22 11.7 8.8 7.3 6.9 1.1 3.6 2 1 1 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly XPA_N PF01286.18 VDK79311.1 - 8.4 6.5 13.5 2 8.6 0.1 3.9 5 0 0 5 5 5 0 XPA protein N-terminal Y_phosphatase PF00102.27 VDK79312.1 - 2.8e-62 210.4 0.4 4.5e-62 209.7 0.4 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK79312.1 - 9.1e-06 25.5 1.2 3.6e-05 23.6 0.1 2.4 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK79312.1 - 0.011 15.7 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 VDK79312.1 - 0.66 10.1 0.0 0.66 10.1 0.0 2.8 3 1 0 3 3 3 0 Inositol hexakisphosphate CHD5 PF04420.14 VDK79312.1 - 1.7 8.5 6.5 0.2 11.5 0.7 2.2 1 1 1 2 2 2 0 CHD5-like protein DUF4094 PF13334.6 VDK79312.1 - 2 8.9 5.5 59 4.2 5.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) Hyccin PF09790.9 VDK79313.1 - 2.1e-79 267.0 1.3 2.8e-79 266.6 1.3 1.1 1 0 0 1 1 1 1 Hyccin HA2 PF04408.23 VDK79314.1 - 8.4e-20 71.1 0.0 8.4e-20 71.1 0.0 2.8 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 VDK79314.1 - 1.8e-19 69.9 0.0 3.5e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 VDK79314.1 - 8.1e-13 48.7 0.3 4.6e-12 46.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK79314.1 - 5.1e-07 29.6 1.4 2e-06 27.7 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_22 PF13401.6 VDK79314.1 - 2.4e-05 24.6 0.0 2.4e-05 24.6 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_30 PF13604.6 VDK79314.1 - 0.00026 20.8 0.0 0.00077 19.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 VDK79314.1 - 0.00056 19.0 0.0 0.0026 16.8 0.0 2.1 2 0 0 2 2 2 1 Type II/IV secretion system protein Reprolysin PF01421.19 VDK79314.1 - 0.0027 17.7 0.1 0.0077 16.2 0.0 1.8 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease AAA_19 PF13245.6 VDK79314.1 - 0.0034 17.7 0.5 0.01 16.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 VDK79314.1 - 0.0072 16.3 0.3 0.019 15.0 0.0 1.9 2 0 0 2 2 2 1 Flavivirus DEAD domain DUF3492 PF11997.8 VDK79314.1 - 0.16 11.7 3.6 0.33 10.7 3.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) NACHT PF05729.12 VDK79314.1 - 0.18 11.7 1.7 2.6 7.9 0.0 2.5 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 VDK79314.1 - 1.3 9.5 0.0 1.3 9.5 0.0 3.0 2 1 0 2 2 1 0 AAA domain WD40 PF00400.32 VDK79315.1 - 1.5e-38 130.0 20.8 2.1e-08 34.7 0.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Nucleoporin_N PF08801.11 VDK79315.1 - 0.0036 16.1 0.2 2.6 6.7 0.0 2.9 2 1 1 3 3 3 2 Nup133 N terminal like Nup160 PF11715.8 VDK79315.1 - 0.2 10.3 2.5 1.5 7.4 0.4 3.0 1 1 3 4 4 4 0 Nucleoporin Nup120/160 FPN1 PF06963.12 VDK79316.1 - 2.8e-103 345.8 15.3 3.7e-103 345.4 15.3 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Pro_isomerase PF00160.21 VDK79317.1 - 3.7e-51 173.5 0.1 6.8e-51 172.7 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ApoL PF05461.11 VDK79317.1 - 1.6e-05 24.4 0.0 3e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Apolipoprotein L WD40 PF00400.32 VDK79317.1 - 0.00093 20.0 4.7 0.68 10.9 0.1 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat SR-25 PF10500.9 VDK79318.1 - 0.012 15.3 3.2 0.014 15.0 3.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PA28_beta PF02252.18 VDK79320.1 - 0.072 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit RBD-FIP PF09457.10 VDK79321.1 - 4.7e-11 42.4 1.5 4.7e-11 42.4 1.5 3.2 3 0 0 3 3 3 1 FIP domain ERM PF00769.19 VDK79321.1 - 0.59 9.9 39.2 0.0072 16.2 20.9 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family WD40_alt PF14077.6 VDK79321.1 - 0.75 9.7 4.5 0.36 10.7 0.3 2.7 3 0 0 3 3 3 0 Alternative WD40 repeat motif MAD PF05557.13 VDK79321.1 - 1.2 7.4 38.3 0.53 8.6 35.6 1.7 1 1 1 2 2 2 0 Mitotic checkpoint protein Ax_dynein_light PF10211.9 VDK79321.1 - 1.8 8.5 34.4 2 8.3 6.5 3.4 1 1 2 3 3 3 0 Axonemal dynein light chain BST2 PF16716.5 VDK79321.1 - 4.7 7.9 30.3 0.13 12.8 7.8 4.0 2 1 2 4 4 4 0 Bone marrow stromal antigen 2 TPR_MLP1_2 PF07926.12 VDK79321.1 - 6.6 6.8 36.2 3.1 7.9 16.0 3.6 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HLH PF00010.26 VDK79334.1 - 3.5e-12 46.1 0.9 3.5e-12 46.1 0.9 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SieB PF14163.6 VDK79334.1 - 0.0038 16.7 0.2 0.0047 16.4 0.2 1.2 1 0 0 1 1 1 1 Super-infection exclusion protein B YjeF_N PF03853.15 VDK79335.1 - 3.9e-37 127.8 0.0 5e-37 127.4 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Rab_bind PF16704.5 VDK79335.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Rab binding domain Pkinase PF00069.25 VDK79336.1 - 9.5e-63 212.0 0.0 1.1e-62 211.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK79336.1 - 7e-24 84.5 0.0 1e-23 84.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK79336.1 - 0.00018 20.9 0.0 0.0028 17.0 0.0 2.1 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 VDK79336.1 - 0.00045 20.2 0.0 0.0066 16.4 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 VDK79336.1 - 0.00064 19.1 0.1 0.00099 18.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 VDK79336.1 - 0.023 14.3 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 VDK79336.1 - 0.097 11.6 0.2 0.13 11.2 0.2 1.1 1 0 0 1 1 1 0 Haspin like kinase domain ABC1 PF03109.16 VDK79336.1 - 0.17 12.1 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 ABC1 family Pkinase PF00069.25 VDK79338.1 - 1e-66 225.0 0.2 1.2e-66 224.8 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK79338.1 - 2e-20 73.1 0.0 2.8e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK79338.1 - 1e-06 28.8 0.0 2.5e-05 24.3 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 VDK79338.1 - 0.0022 16.9 0.0 0.0088 14.9 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 VDK79338.1 - 0.0039 16.8 0.1 0.0069 16.0 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 VDK79338.1 - 0.0062 15.9 0.1 0.01 15.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 VDK79338.1 - 0.049 13.2 0.2 0.11 12.1 0.2 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase GP17 PF17420.2 VDK79338.1 - 0.082 13.1 0.9 0.72 10.1 0.2 2.5 2 0 0 2 2 2 0 Superinfection exclusion gene product 17 Aminotran_5 PF00266.19 VDK79339.1 - 1.3e-86 290.9 0.0 1.6e-86 290.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 VDK79339.1 - 4.6e-06 26.1 0.1 6.4e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 VDK79339.1 - 4.1e-05 23.1 0.5 0.00057 19.3 0.1 2.1 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 VDK79339.1 - 0.0016 17.2 0.0 0.0027 16.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Tub PF01167.18 VDK79340.1 - 6.9e-29 101.3 0.5 3e-25 89.4 0.1 2.6 2 0 0 2 2 2 2 Tub family ANAPC4_WD40 PF12894.7 VDK79340.1 - 3.5e-08 33.6 3.1 1.1 9.5 0.1 5.4 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF3527 PF12043.8 VDK79340.1 - 0.00083 19.0 0.0 0.0019 17.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3527) WD40 PF00400.32 VDK79340.1 - 0.00091 20.0 6.4 1.9 9.5 0.1 4.9 4 1 1 5 5 4 1 WD domain, G-beta repeat BLOC1_2 PF10046.9 VDK79340.1 - 0.0047 17.2 1.1 0.34 11.2 0.2 3.1 3 0 0 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 VDK79340.1 - 0.0066 16.5 3.1 3.6 7.6 0.3 3.4 2 1 1 3 3 3 1 Laminin Domain II KxDL PF10241.9 VDK79340.1 - 0.021 15.1 3.7 2 8.7 0.1 2.9 4 0 0 4 4 2 0 Uncharacterized conserved protein TBK1_CCD1 PF18394.1 VDK79340.1 - 0.058 13.0 2.2 0.058 13.0 0.8 1.7 2 0 0 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 BLI1 PF17324.2 VDK79340.1 - 0.073 13.7 0.1 0.18 12.5 0.1 1.6 1 0 0 1 1 1 0 BLOC-1 interactor 1 NPV_P10 PF05531.12 VDK79340.1 - 0.11 13.0 1.2 0.92 10.0 0.1 2.9 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 VDK79340.1 - 0.17 12.3 0.2 0.53 10.7 0.2 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Lectin_N PF03954.14 VDK79340.1 - 1.4 8.7 4.2 13 5.6 0.7 2.7 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain SCAMP PF04144.13 VDK79341.1 - 8.6e-56 189.0 24.0 1.1e-55 188.7 24.0 1.1 1 0 0 1 1 1 1 SCAMP family Spectrin PF00435.21 VDK79344.1 - 2.3e-06 28.0 3.4 2.3e-06 28.0 3.4 4.0 6 0 0 6 6 6 2 Spectrin repeat DUF4363 PF14276.6 VDK79344.1 - 0.00015 21.8 2.0 0.015 15.4 0.7 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4363) OKR_DC_1_N PF03709.15 VDK79344.1 - 0.081 13.2 0.0 0.34 11.2 0.0 2.0 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain TIP49 PF06068.13 VDK79344.1 - 0.086 12.0 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Cytochrom_B562 PF07361.11 VDK79344.1 - 0.28 11.8 6.7 0.51 11.0 0.5 3.3 1 1 2 3 3 3 0 Cytochrome b562 Histone PF00125.24 VDK79347.1 - 1.6e-15 57.6 0.0 2.3e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 VDK79347.1 - 2.3e-08 33.6 0.0 1.1e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 VDK79347.1 - 8.4e-05 22.8 0.0 0.00015 22.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone OST3_OST6 PF04756.13 VDK79348.1 - 2.1e-08 33.9 0.2 2.5e-08 33.6 0.2 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Rib_5-P_isom_A PF06026.14 VDK79349.1 - 9.5e-61 204.4 0.0 1.2e-60 204.1 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 VDK79349.1 - 0.025 14.5 0.1 0.41 10.6 0.0 2.2 1 1 1 2 2 2 0 DeoR C terminal sensor domain BpuJI_N PF11564.8 VDK79349.1 - 0.14 11.4 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease BpuJI - N terminal Sugar-bind PF04198.13 VDK79349.1 - 0.14 11.2 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain TPR_2 PF07719.17 VDK79352.1 - 6.8e-13 47.7 12.9 0.03 14.4 0.0 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 VDK79352.1 - 7.5e-13 48.8 8.3 1.5e-06 28.6 0.3 4.4 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 VDK79352.1 - 1.4e-10 41.1 12.0 0.0061 17.3 0.3 6.1 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 VDK79352.1 - 4.7e-10 39.9 9.7 0.013 16.2 0.1 5.6 4 2 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK79352.1 - 6.2e-07 29.5 13.6 0.002 18.3 0.1 3.7 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 VDK79352.1 - 1.2e-06 28.1 12.6 0.094 12.6 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK79352.1 - 9e-06 25.5 9.1 1.4 9.3 0.0 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK79352.1 - 3.5e-05 23.4 3.9 0.0089 15.7 0.1 5.0 5 1 1 6 6 6 1 TPR repeat TPR_21 PF09976.9 VDK79352.1 - 8.5e-05 22.4 9.6 0.00049 19.9 2.5 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain HrpB1_HrpK PF09613.10 VDK79352.1 - 0.00023 20.8 7.1 0.45 10.2 0.6 3.5 2 2 1 3 3 3 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_15 PF13429.6 VDK79352.1 - 0.0008 18.7 14.9 0.016 14.4 3.5 3.4 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 VDK79352.1 - 0.0054 16.6 6.5 4.3 7.3 0.1 5.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK79352.1 - 0.0061 16.8 16.2 4.5 7.6 0.1 5.8 5 3 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK79352.1 - 0.027 14.8 4.6 81 3.9 0.0 6.1 9 0 0 9 9 6 0 Tetratricopeptide repeat ChAPs PF09295.10 VDK79352.1 - 0.04 12.9 0.5 0.056 12.4 0.5 1.3 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.6 VDK79352.1 - 0.04 13.9 3.6 19 5.6 0.0 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TOM20_plant PF06552.12 VDK79352.1 - 0.05 13.3 0.5 9.1 6.0 0.1 2.7 2 0 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 RPN7 PF10602.9 VDK79352.1 - 0.19 11.4 3.5 0.13 12.0 0.9 1.9 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TED_complement PF07678.14 VDK79352.1 - 0.44 9.5 5.9 0.34 9.9 0.3 2.7 2 1 1 3 3 3 0 A-macroglobulin TED domain DUF4919 PF16266.5 VDK79352.1 - 1 9.3 3.3 28 4.6 0.1 2.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4919) Reeler PF02014.16 VDK79365.1 - 1.1e-11 45.6 0.0 1.8e-11 44.9 0.0 1.4 1 0 0 1 1 1 1 Reeler domain DOMON PF03351.17 VDK79365.1 - 0.12 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 DOMON domain Calreticulin PF00262.18 VDK79367.1 - 1.4e-55 188.7 27.5 2.9e-20 72.5 10.4 4.2 1 1 3 4 4 4 4 Calreticulin family Astro_capsid_p PF12226.8 VDK79367.1 - 0.12 11.5 3.5 0.19 10.8 3.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein MDM10 PF12519.8 VDK79367.1 - 1.2 7.9 7.4 1.7 7.5 7.4 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2681 PF10883.8 VDK79367.1 - 5.2 7.5 10.1 9.2 6.8 10.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Calreticulin PF00262.18 VDK79370.1 - 9.5e-85 284.6 21.8 6.8e-65 219.3 9.4 3.0 2 1 1 3 3 3 2 Calreticulin family MDM10 PF12519.8 VDK79370.1 - 0.18 10.7 15.6 0.25 10.2 15.6 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 VDK79370.1 - 1.1 9.3 4.3 1.3 9.0 4.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 VDK79370.1 - 1.2 9.3 8.5 1.9 8.6 8.5 1.3 1 0 0 1 1 1 0 DDHD domain UcrQ PF02939.16 VDK79372.1 - 5.8e-20 71.0 0.5 7.2e-20 70.7 0.5 1.1 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 VDK79372.1 - 0.00088 19.6 0.5 0.0013 19.1 0.2 1.6 2 0 0 2 2 2 1 Cytochrome b-c1 complex subunit 8 SET PF00856.28 VDK79374.1 - 3.8e-09 37.2 0.0 2.7e-07 31.1 0.0 2.5 1 1 0 1 1 1 1 SET domain Abhydrolase_6 PF12697.7 VDK79379.1 - 5.1e-24 86.1 0.0 6.4e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 VDK79379.1 - 1.6e-12 47.7 0.1 1.8e-11 44.2 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK79379.1 - 1.1e-09 38.0 0.2 1.5e-09 37.5 0.2 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 VDK79379.1 - 0.0056 16.8 0.0 0.01 16.0 0.0 1.4 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 VDK79379.1 - 0.013 15.3 0.6 0.082 12.7 0.6 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 VDK79379.1 - 0.015 14.9 0.6 0.25 11.0 0.3 2.5 2 1 0 2 2 2 0 Putative esterase Ser_hydrolase PF06821.13 VDK79379.1 - 0.074 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase PGAP1 PF07819.13 VDK79379.1 - 0.09 12.5 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 VDK79379.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) DUF2650 PF10853.8 VDK79380.1 - 0.0013 18.4 5.0 0.0027 17.4 5.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2650) Proteasom_Rpn13 PF04683.13 VDK79388.1 - 1.3e-28 99.3 0.1 2.5e-28 98.4 0.1 1.5 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 VDK79388.1 - 1.9e-22 79.5 0.0 4.9e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 UCH-binding domain DUF4507 PF14964.6 VDK79389.1 - 2.3e-24 86.0 0.1 3e-24 85.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) RdDM_RDM1 PF09187.10 VDK79389.1 - 0.04 14.0 0.0 0.079 13.0 0.0 1.4 1 0 0 1 1 1 0 RNA-directed DNA methylation 1 F-box-like PF12937.7 VDK79391.1 - 0.00017 21.4 0.0 0.0004 20.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 VDK79391.1 - 0.0015 18.4 0.1 0.0038 17.1 0.1 1.7 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 VDK79391.1 - 0.0026 18.1 2.7 0.19 12.2 0.2 3.3 3 1 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 VDK79391.1 - 0.011 15.8 0.5 14 6.0 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich repeat F-box_5 PF18511.1 VDK79391.1 - 0.012 15.1 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 F-box HA2 PF04408.23 VDK79392.1 - 4.3e-22 78.4 0.0 4.3e-22 78.4 0.0 3.6 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 VDK79392.1 - 6.3e-15 55.3 0.0 1.3e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 VDK79392.1 - 2e-11 44.2 0.0 4.3e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK79392.1 - 2.4e-07 30.7 0.0 6.3e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 VDK79392.1 - 9.5e-06 25.9 0.1 3.3e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK79392.1 - 0.00017 21.4 0.0 0.00035 20.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 VDK79392.1 - 0.0022 17.6 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 VDK79392.1 - 0.012 16.0 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 VDK79392.1 - 0.039 13.0 0.0 0.089 11.8 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 VDK79392.1 - 0.044 13.1 0.1 0.11 11.9 0.1 1.6 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 VDK79392.1 - 0.08 12.4 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein EMP24_GP25L PF01105.24 VDK79392.1 - 0.31 11.0 2.0 1.5 8.7 0.2 2.4 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD AAA_23 PF13476.6 VDK79392.1 - 0.32 11.5 0.0 0.32 11.5 0.0 3.4 4 0 0 4 4 4 0 AAA domain XhlA PF10779.9 VDK79392.1 - 8.3 6.7 6.6 0.97 9.7 1.5 2.0 2 0 0 2 2 2 0 Haemolysin XhlA TB2_DP1_HVA22 PF03134.19 VDK79393.1 - 4.4e-26 90.6 10.9 7.7e-26 89.8 10.9 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Mg_trans_NIPA PF05653.14 VDK79394.1 - 1.6e-123 411.5 20.6 2e-123 411.3 20.6 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 VDK79394.1 - 2.9e-07 30.7 4.1 2.9e-07 30.7 4.1 3.6 3 1 0 3 3 3 1 EamA-like transporter family DUF5383 PF17355.2 VDK79394.1 - 0.035 14.5 2.3 3.6 8.0 0.4 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5383) YlaC PF10777.9 VDK79394.1 - 3.7 7.4 7.8 3.7 7.4 1.2 2.5 2 0 0 2 2 2 0 Inner membrane protein YlaC ATP_bind_1 PF03029.17 VDK79396.1 - 4.3e-77 259.2 0.1 5.9e-77 258.7 0.1 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 VDK79396.1 - 0.0002 21.8 0.0 0.00065 20.1 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain GTP_EFTU PF00009.27 VDK79396.1 - 0.00026 20.6 0.0 0.0025 17.4 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 VDK79396.1 - 0.0005 19.1 0.1 0.04 12.9 0.1 2.2 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 VDK79396.1 - 0.00063 19.7 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain RsgA_GTPase PF03193.16 VDK79396.1 - 0.0015 18.5 1.3 1.3 8.9 0.0 2.8 3 0 0 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 VDK79396.1 - 0.0034 17.5 0.0 0.016 15.2 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_5 PF07728.14 VDK79396.1 - 0.0068 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 VDK79396.1 - 0.011 15.9 0.0 0.025 14.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK79396.1 - 0.012 15.9 0.0 0.056 13.7 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 VDK79396.1 - 0.028 14.0 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 VDK79396.1 - 0.035 14.7 0.0 0.11 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 VDK79396.1 - 0.036 14.0 0.1 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Ras PF00071.22 VDK79396.1 - 0.037 13.6 0.0 5.4 6.6 0.0 2.4 1 1 1 2 2 2 0 Ras family G-alpha PF00503.20 VDK79396.1 - 0.042 13.0 0.9 6.5 5.8 0.0 2.4 2 1 0 2 2 2 0 G-protein alpha subunit FeoB_N PF02421.18 VDK79396.1 - 0.062 12.8 0.0 0.25 10.8 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF87 PF01935.17 VDK79396.1 - 0.065 13.3 0.1 0.25 11.4 0.0 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain Viral_helicase1 PF01443.18 VDK79396.1 - 0.066 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PRK PF00485.18 VDK79396.1 - 0.069 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family SRP54 PF00448.22 VDK79396.1 - 0.082 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 VDK79396.1 - 0.15 11.9 0.0 0.34 10.8 0.0 1.6 1 0 0 1 1 1 0 NTPase Roc PF08477.13 VDK79396.1 - 0.17 12.1 0.0 3.9 7.7 0.0 2.5 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 VDK79396.1 - 0.18 11.0 0.4 0.59 9.3 0.0 1.9 3 0 0 3 3 3 0 NB-ARC domain Rep_fac-A_C PF08646.10 VDK79398.1 - 9.1e-27 93.6 4.8 1.5e-26 92.9 3.3 2.0 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 VDK79398.1 - 7.6e-20 70.7 0.0 8.9e-18 64.0 0.0 2.8 3 0 0 3 3 3 1 Replication protein A OB domain BRCA2 PF00634.18 VDK79398.1 - 6.4e-09 35.3 0.0 2.5e-08 33.5 0.0 2.1 1 0 0 1 1 1 1 BRCA2 repeat tRNA_anti-codon PF01336.25 VDK79398.1 - 3.4e-05 23.7 0.4 0.0048 16.9 0.0 2.8 3 0 0 3 3 3 1 OB-fold nucleic acid binding domain FAM35_C PF15793.5 VDK79398.1 - 0.0045 16.4 0.3 0.0079 15.6 0.3 1.3 1 0 0 1 1 1 1 Protein family FAM35, C-terminal C1_2 PF03107.16 VDK79398.1 - 0.043 14.1 1.6 0.13 12.6 1.6 1.9 1 0 0 1 1 1 0 C1 domain PaaX_C PF08223.11 VDK79398.1 - 0.15 12.3 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Glycos_transf_2 PF00535.26 VDK79399.1 - 1.7e-28 99.6 0.0 2.7e-28 98.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 VDK79399.1 - 1.5e-13 51.1 1.3 2.7e-13 50.3 1.3 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 VDK79399.1 - 4.6e-07 30.0 0.0 7.6e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 VDK79399.1 - 3.3e-06 26.8 0.0 5.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 VDK79399.1 - 2.2e-05 24.0 0.0 4.8e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase FOXP-CC PF16159.5 VDK79400.1 - 0.00081 20.0 0.1 0.026 15.1 0.0 2.9 2 0 0 2 2 2 1 FOXP coiled-coil domain RIG-I_C-RD PF11648.8 VDK79400.1 - 0.0071 16.6 0.7 0.35 11.1 0.1 3.2 2 0 0 2 2 2 1 C-terminal domain of RIG-I zf-C2H2_4 PF13894.6 VDK79400.1 - 0.43 11.5 0.2 0.43 11.5 0.2 6.2 6 0 0 6 6 6 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 VDK79400.1 - 1.9 8.7 7.4 22 5.3 0.4 3.8 3 0 0 3 3 3 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 VDK79400.1 - 4.4 7.9 12.1 22 5.7 0.5 4.9 5 0 0 5 5 5 0 Zinc-finger double domain C2 PF00168.30 VDK79426.1 - 0.044 14.1 0.0 0.055 13.8 0.0 1.1 1 0 0 1 1 1 0 C2 domain BNR_3 PF13859.6 VDK79426.1 - 0.062 12.6 0.0 0.065 12.5 0.0 1.1 1 0 0 1 1 1 0 BNR repeat-like domain DNA_ligase_A_M PF01068.21 VDK79427.1 - 3.4e-53 180.3 2.3 4.5e-53 179.9 0.7 2.1 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 VDK79427.1 - 8.9e-31 107.5 1.1 8.9e-31 107.5 1.1 2.6 4 0 0 4 4 4 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 VDK79427.1 - 5e-18 65.5 0.1 1.8e-17 63.7 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region zf-CCHH PF10283.9 VDK79427.1 - 6.5e-10 38.8 4.2 1.1e-09 38.0 4.2 1.4 1 0 0 1 1 1 1 PBZ domain RNA_ligase PF09414.10 VDK79427.1 - 2.3e-07 31.3 0.0 4.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 VDK79427.1 - 0.00063 19.6 0.4 0.0019 18.1 0.3 1.9 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain Homez PF11569.8 VDK79427.1 - 0.16 11.5 0.0 0.39 10.2 0.0 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez zf-PARP PF00645.18 VDK79428.1 - 2.1e-15 57.4 0.3 3.1e-15 56.8 0.3 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region MG4 PF17789.1 VDK79429.1 - 0.19 11.9 0.0 0.24 11.6 0.0 1.2 1 0 0 1 1 1 0 Macroglobulin domain MG4 UCH PF00443.29 VDK79430.1 - 1.5e-68 231.1 0.1 2.4e-68 230.4 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK79430.1 - 2.1e-12 47.3 4.8 1e-08 35.2 0.0 3.5 4 0 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase zf-MYND PF01753.18 VDK79430.1 - 3e-10 40.0 14.2 3e-10 40.0 14.2 3.3 3 0 0 3 3 3 1 MYND finger USP7_C2 PF14533.6 VDK79430.1 - 0.00023 20.9 0.0 0.00046 19.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal Peptidase_C98 PF15499.6 VDK79430.1 - 0.0046 16.5 1.9 0.3 10.5 0.1 3.2 3 1 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase AKAP7_NLS PF10469.9 VDK79432.1 - 3.7e-46 157.6 0.7 5.5e-46 157.1 0.7 1.3 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 VDK79432.1 - 0.00059 19.8 0.0 0.00092 19.1 0.0 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily KH_1 PF00013.29 VDK79432.1 - 0.004 16.9 0.0 0.01 15.7 0.0 1.7 1 0 0 1 1 1 1 KH domain DUF3823_C PF18003.1 VDK79432.1 - 2.6 8.8 7.6 1.2 9.9 0.2 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF3823_C) DUF4407 PF14362.6 VDK79435.1 - 0.095 12.0 4.0 0.1 11.9 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) G_path_suppress PF15991.5 VDK79435.1 - 6.1 6.9 13.8 7.5 6.6 13.8 1.1 1 0 0 1 1 1 0 G-protein pathway suppressor Fra10Ac1 PF09725.9 VDK79436.1 - 2.8e-49 166.3 5.1 6.9e-49 165.1 5.1 1.7 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 ICMT PF04140.14 VDK79437.1 - 8.7e-28 96.6 1.2 8.7e-28 96.6 1.2 2.5 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 VDK79437.1 - 3.6e-11 43.4 2.9 3.6e-11 43.4 2.9 2.2 3 0 0 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.12 VDK79437.1 - 0.0084 15.6 1.0 0.0084 15.6 1.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1295) KH_1 PF00013.29 VDK79439.1 - 6.1e-164 532.1 42.6 6.9e-14 51.4 1.0 15.3 15 0 0 15 15 15 15 KH domain SLS PF14611.6 VDK79439.1 - 8.3e-15 55.2 20.2 0.046 13.5 0.0 8.6 2 2 6 8 8 8 6 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 VDK79439.1 - 2.6e-14 52.8 20.6 0.02 14.7 0.2 9.4 8 1 1 9 9 9 5 KH domain KH_5 PF13184.6 VDK79439.1 - 0.0064 16.5 17.2 7.3 6.8 0.4 7.3 7 1 1 8 8 8 2 NusA-like KH domain DUF2431 PF10354.9 VDK79439.1 - 0.021 15.1 1.0 0.1 12.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) Ntox17 PF15524.6 VDK79439.1 - 0.03 14.6 0.0 0.091 13.1 0.0 1.9 1 0 0 1 1 1 0 Novel toxin 17 DnaB_bind PF10410.9 VDK79439.1 - 0.08 13.1 0.2 0.32 11.2 0.2 2.1 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase DUF2096 PF09869.9 VDK79439.1 - 0.38 10.8 16.1 3.2 7.8 0.4 7.7 10 1 1 11 11 11 0 Uncharacterized protein conserved in archaea (DUF2096) DUF3482 PF11981.8 VDK79439.1 - 0.43 9.9 0.0 0.43 9.9 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3482) Exonuc_VII_S PF02609.16 VDK79439.1 - 0.49 10.5 3.8 19 5.4 0.4 3.1 2 0 0 2 2 2 0 Exonuclease VII small subunit Mt_ATP-synt_D PF05873.12 VDK79439.1 - 0.59 10.0 5.5 16 5.4 0.1 3.7 3 0 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) KH_4 PF13083.6 VDK79439.1 - 0.88 9.5 15.8 15 5.5 0.0 8.0 8 1 2 10 10 10 0 KH domain DUF4974 PF16344.5 VDK79439.1 - 3.6 7.7 7.0 6 7.0 0.1 4.0 5 0 0 5 5 4 0 Domain of unknown function (DUF4974) Metallophos PF00149.28 VDK79440.1 - 2.1e-10 41.5 0.1 3e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.6 VDK79440.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily S6PP PF05116.13 VDK79452.1 - 0.029 13.9 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase Peptidase_S64 PF08192.11 VDK79452.1 - 0.06 11.8 1.9 0.075 11.5 1.9 1.2 1 0 0 1 1 1 0 Peptidase family S64 Viral_cys_rich PF08008.12 VDK79453.1 - 0.027 14.5 0.3 0.11 12.6 0.2 2.1 2 0 0 2 2 2 0 Viral cysteine rich Frizzled PF01534.17 VDK79454.1 - 2.5e-104 348.8 19.9 3.3e-104 348.4 19.9 1.1 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Dicty_CAR PF05462.11 VDK79454.1 - 1.3e-05 24.5 6.6 1.3e-05 24.5 6.6 1.7 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor WD40 PF00400.32 VDK79456.1 - 5.5e-27 93.5 15.2 0.0024 18.7 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat NLE PF08154.12 VDK79456.1 - 1.2e-12 48.2 1.4 2e-12 47.4 1.4 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Cir_N PF10197.9 VDK79457.1 - 7.8e-10 38.8 6.6 7.8e-10 38.8 6.6 3.7 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR zf-CCHC_6 PF15288.6 VDK79457.1 - 0.0005 19.9 0.3 0.0014 18.4 0.3 1.8 1 0 0 1 1 1 1 Zinc knuckle NST1 PF13945.6 VDK79457.1 - 0.017 15.2 4.7 0.017 15.2 4.7 2.6 2 1 1 3 3 3 0 Salt tolerance down-regulator CDC45 PF02724.14 VDK79457.1 - 2 6.6 20.4 4.1 5.6 20.4 1.5 1 0 0 1 1 1 0 CDC45-like protein Milton PF12448.8 VDK79467.1 - 0.00028 21.1 2.1 0.00053 20.2 2.2 1.5 1 1 0 1 1 1 1 Kinesin associated protein ClpS PF02617.17 VDK79468.1 - 2e-21 75.5 0.2 1.1e-20 73.2 0.0 2.3 2 0 0 2 2 2 1 ATP-dependent Clp protease adaptor protein ClpS zf-UBR PF02207.20 VDK79468.1 - 1.7e-17 63.3 15.2 1.7e-17 63.3 15.2 2.8 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Sec10 PF07393.11 VDK79469.1 - 3.6e-133 445.5 13.5 3e-129 432.6 13.5 3.2 1 1 0 1 1 1 1 Exocyst complex component Sec10 V_ATPase_I PF01496.19 VDK79469.1 - 0.028 12.4 3.5 0.039 11.9 3.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF948 PF06103.11 VDK79469.1 - 0.034 14.4 0.2 0.2 12.0 0.3 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Jnk-SapK_ap_N PF09744.9 VDK79469.1 - 0.036 14.3 2.7 0.14 12.3 2.7 2.0 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 FAM184 PF15665.5 VDK79469.1 - 0.59 9.9 7.9 0.15 11.8 3.6 2.1 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B RPAP3_C PF13877.6 VDK79470.1 - 1.5e-11 44.7 0.0 2.9e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_17 PF13431.6 VDK79470.1 - 0.0015 18.8 2.7 0.24 11.9 0.2 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK79470.1 - 0.002 18.1 7.3 0.19 11.9 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK79470.1 - 0.0023 18.4 2.4 0.041 14.4 1.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF3231 PF11553.8 VDK79470.1 - 0.015 15.0 0.6 0.042 13.5 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3231) TPR_1 PF00515.28 VDK79470.1 - 0.025 14.4 5.6 1.3 9.0 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK79470.1 - 0.076 13.3 6.3 19 5.8 0.4 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 VDK79470.1 - 0.11 12.2 0.5 3.5 7.4 0.1 2.7 2 1 0 2 2 2 0 TPR repeat TPR_12 PF13424.6 VDK79470.1 - 1 9.7 4.2 1 9.7 0.2 2.8 2 2 0 2 2 2 0 Tetratricopeptide repeat EB PF01683.18 VDK79473.1 - 0.054 13.8 10.6 0.091 13.1 10.6 1.3 1 0 0 1 1 1 0 EB module PLA2G12 PF06951.11 VDK79473.1 - 0.16 11.8 9.9 0.25 11.2 9.1 1.7 1 1 0 1 1 1 0 Group XII secretory phospholipase A2 precursor (PLA2G12) Phospholip_A2_1 PF00068.19 VDK79473.1 - 0.18 12.3 9.9 0.3 11.6 9.5 1.5 1 1 0 1 1 1 0 Phospholipase A2 zf-C4 PF00105.18 VDK79484.1 - 7.9e-30 103.1 13.0 1.3e-29 102.4 13.0 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK79484.1 - 3.6e-15 56.1 0.0 2e-14 53.7 0.0 2.0 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor NUDIX PF00293.28 VDK79485.1 - 5.1e-14 52.4 0.0 8.3e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain tRNA-synt_2 PF00152.20 VDK79487.1 - 7.4e-77 258.5 0.0 1.2e-76 257.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 VDK79487.1 - 5e-12 45.6 0.0 1.4e-11 44.2 0.0 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 VDK79487.1 - 2e-10 40.6 0.0 2.2e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) ATP-synt_E PF05680.12 VDK79487.1 - 7.2 7.0 9.8 0.74 10.2 5.3 1.6 2 0 0 2 2 2 0 ATP synthase E chain PCI PF01399.27 VDK79488.1 - 1.4e-08 35.2 0.4 7.4e-08 32.8 0.1 2.4 2 1 0 2 2 2 1 PCI domain SNF2_N PF00176.23 VDK79490.1 - 5.7e-61 206.2 0.0 1.1e-60 205.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK79490.1 - 6.1e-21 74.9 0.0 2.2e-20 73.0 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 VDK79490.1 - 0.0021 17.3 0.0 0.0064 15.7 0.0 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase KCNQ_channel PF03520.14 VDK79491.1 - 6.5e-30 104.4 12.8 3.2e-29 102.1 7.1 3.0 2 1 0 2 2 2 1 KCNQ voltage-gated potassium channel Ion_trans PF00520.31 VDK79491.1 - 1.8e-27 96.1 12.6 3.2e-27 95.3 12.6 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 VDK79491.1 - 5.4e-14 51.9 3.8 5.4e-14 51.9 3.8 2.3 3 0 0 3 3 3 1 Ion channel Fer4_18 PF13746.6 VDK79491.1 - 0.075 13.2 0.2 0.2 11.9 0.2 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain DUF2798 PF11391.8 VDK79491.1 - 0.19 11.8 0.1 0.19 11.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) DUF373 PF04123.13 VDK79491.1 - 1.2 8.5 3.7 2.8 7.3 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Peptidase_S8 PF00082.22 VDK79502.1 - 1.6e-56 191.8 2.2 1.6e-56 191.8 2.2 1.9 3 0 0 3 3 3 1 Subtilase family P_proprotein PF01483.20 VDK79502.1 - 5.6e-25 87.2 0.1 1.3e-24 86.0 0.1 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 VDK79502.1 - 2.2e-10 41.2 0.0 1.8e-09 38.2 0.0 2.3 2 0 0 2 2 2 1 Peptidase S8 pro-domain DUF5466 PF17554.2 VDK79502.1 - 0.14 12.4 0.7 0.33 11.2 0.7 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5466) TRAP_alpha PF03896.16 VDK79503.1 - 5.9e-82 275.1 0.6 7.5e-82 274.7 0.6 1.0 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Sec34 PF04136.15 VDK79504.1 - 3.9e-38 130.7 3.8 1.3e-37 128.9 3.8 2.0 1 0 0 1 1 1 1 Sec34-like family SHE3 PF17078.5 VDK79504.1 - 0.084 12.6 1.6 0.21 11.3 1.6 1.6 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Cyclin_N PF00134.23 VDK79505.1 - 1.7e-11 44.0 1.0 3.3e-11 43.0 1.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain zf-C2H2 PF00096.26 VDK79507.1 - 0.037 14.5 1.5 0.12 12.9 1.5 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF3603 PF12227.8 VDK79507.1 - 0.051 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3603) Myosin_head PF00063.21 VDK79508.1 - 4.6e-226 752.2 0.1 7.5e-226 751.5 0.1 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin-VI_CBD PF16521.5 VDK79508.1 - 2.7e-38 129.8 0.0 2.8e-37 126.6 0.0 2.7 2 0 0 2 2 2 1 Myosin VI cargo binding domain AAA_22 PF13401.6 VDK79508.1 - 0.015 15.5 0.1 0.12 12.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain Myosin_N PF02736.19 VDK79508.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 VDK79508.1 - 0.16 12.3 0.0 0.16 12.3 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain CBM_1 PF00734.18 VDK79508.1 - 1.8 8.6 3.7 3.7 7.6 3.7 1.5 1 0 0 1 1 1 0 Fungal cellulose binding domain CTNNBL PF08216.11 VDK79509.1 - 1.5e-34 118.3 0.6 1.5e-34 118.3 0.6 2.0 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear SEN1_N PF12726.7 VDK79509.1 - 0.0047 15.2 0.2 0.016 13.5 0.0 1.9 2 0 0 2 2 2 1 SEN1 N terminal Cnd1 PF12717.7 VDK79509.1 - 0.046 13.7 1.9 1.6 8.8 0.8 3.3 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 VDK79509.1 - 0.1 12.7 0.1 0.45 10.6 0.1 2.3 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat DUF2887 PF11103.8 VDK79509.1 - 0.17 11.9 1.7 40 4.1 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2887) RTP1_C1 PF10363.9 VDK79509.1 - 0.33 11.1 2.7 0.63 10.2 0.5 2.6 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 TFCD_C PF12612.8 VDK79510.1 - 4.9e-35 121.1 2.3 1.5e-34 119.5 0.6 2.4 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal DUF2009 PF09418.10 VDK79510.1 - 0.0012 18.0 0.4 0.1 11.6 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF2009) CTK3 PF12243.8 VDK79510.1 - 0.13 12.3 1.2 2.4 8.2 0.1 2.5 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 Hydrolase PF00702.26 VDK79517.1 - 1.9e-14 54.5 0.0 8.9e-06 26.1 0.0 2.6 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 VDK79517.1 - 0.0034 17.2 0.1 0.54 9.9 0.0 3.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase 2-Hacid_dh_C PF02826.19 VDK79517.1 - 0.058 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SET PF00856.28 VDK79518.1 - 2.3e-20 73.7 0.0 4.2e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 SET domain SCVP PF17619.2 VDK79518.1 - 0.18 12.7 0.2 4.5 8.2 0.0 2.7 3 0 0 3 3 3 0 Secreted clade V proteins Zwilch PF09817.9 VDK79520.1 - 0.0073 14.8 2.4 0.01 14.4 2.4 1.1 1 0 0 1 1 1 1 RZZ complex, subunit zwilch GldM_N PF12081.8 VDK79520.1 - 0.0099 16.0 1.3 0.015 15.4 1.3 1.2 1 0 0 1 1 1 1 GldM N-terminal domain AATF-Che1 PF13339.6 VDK79520.1 - 0.04 14.6 1.8 0.064 13.9 1.8 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF733 PF05306.11 VDK79520.1 - 0.046 14.0 1.3 0.079 13.3 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF733) YlbD_coat PF14071.6 VDK79520.1 - 0.27 11.5 4.6 0.46 10.7 3.2 1.8 1 1 1 2 2 2 0 Putative coat protein PurA PF04845.13 VDK79525.1 - 2.7e-78 262.3 0.4 3e-78 262.1 0.4 1.0 1 0 0 1 1 1 1 PurA ssDNA and RNA-binding protein DUF3276 PF11680.8 VDK79525.1 - 0.0021 18.2 0.6 0.39 10.9 0.0 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF3276) DUF3467 PF11950.8 VDK79525.1 - 0.02 15.1 0.0 1.1 9.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3467) Tubulin PF00091.25 VDK79526.1 - 3.3e-69 233.0 0.0 4.5e-69 232.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK79526.1 - 3.7e-51 172.5 0.0 6.5e-51 171.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK79526.1 - 0.00024 20.9 0.0 0.00043 20.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Histone PF00125.24 VDK79527.1 - 3.6e-18 66.2 0.0 5e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 VDK79527.1 - 2.5e-12 46.3 0.0 4.9e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 VDK79527.1 - 0.0024 18.1 0.0 0.004 17.4 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone PH_9 PF15410.6 VDK79528.1 - 1.1e-42 145.2 0.0 2.5e-42 144.0 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Sec7 PF01369.20 VDK79528.1 - 8e-38 129.9 0.0 1.4e-37 129.1 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 VDK79528.1 - 3.1e-09 37.3 0.0 6.7e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_2 PF08458.10 VDK79528.1 - 0.13 12.6 0.0 0.45 10.9 0.0 1.9 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PHD PF00628.29 VDK79529.1 - 2.5e-10 40.1 10.6 2.5e-10 40.1 10.6 4.0 3 1 0 3 3 3 2 PHD-finger zf-CpG_bind_C PF12269.8 VDK79530.1 - 5.3e-45 154.0 7.5 6.3e-45 153.8 7.5 1.1 1 0 0 1 1 1 1 CpG binding protein zinc finger C terminal domain PMM PF03332.13 VDK79531.1 - 3.9e-63 213.2 0.1 8e-49 166.4 0.0 2.0 1 1 1 2 2 2 2 Eukaryotic phosphomannomutase Ank_2 PF12796.7 VDK79532.1 - 1.9e-49 166.1 20.1 2e-10 41.1 0.0 7.9 2 2 6 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK79532.1 - 9.5e-33 112.2 26.1 3.2e-08 34.0 0.3 9.7 6 2 5 11 11 11 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK79532.1 - 1.8e-31 107.8 26.4 2.6e-09 37.1 0.1 11.4 7 5 5 12 12 12 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK79532.1 - 7e-30 99.7 25.1 0.00033 20.9 0.0 14.2 16 0 0 16 16 16 7 Ankyrin repeat Ank PF00023.30 VDK79532.1 - 1.5e-27 94.7 27.1 2.2e-05 24.7 0.0 12.8 13 1 1 14 14 14 8 Ankyrin repeat NABP PF07990.12 VDK79532.1 - 0.014 14.9 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Nucleic acid binding protein NABP DapH_N PF08503.10 VDK79532.1 - 0.1 12.8 0.0 4.7 7.5 0.0 2.7 2 0 0 2 2 2 0 Tetrahydrodipicolinate succinyltransferase N-terminal ASC PF00858.24 VDK79540.1 - 1.7e-118 396.4 9.3 7.1e-118 394.4 9.3 2.0 1 1 0 1 1 1 1 Amiloride-sensitive sodium channel Mucin PF01456.17 VDK79540.1 - 0.46 10.5 31.0 0.91 9.5 9.9 2.9 3 0 0 3 3 3 0 Mucin-like glycoprotein PPTA PF01239.22 VDK79541.1 - 4.3e-35 118.4 15.3 4.7e-08 32.5 0.3 5.7 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat LRR_4 PF12799.7 VDK79541.1 - 0.00052 20.3 0.0 0.0047 17.3 0.0 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 VDK79541.1 - 0.0089 15.8 0.2 0.023 14.4 0.2 1.8 1 0 0 1 1 1 1 Leucine rich repeat LSM PF01423.22 VDK79543.1 - 6.9e-20 70.5 0.0 1.2e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 LSM domain HECT PF00632.25 VDK79553.1 - 1.3e-79 267.8 0.1 1.9e-79 267.4 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Astacin PF01400.24 VDK79554.1 - 5.4e-71 238.2 0.0 8.6e-71 237.5 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Rotamase_2 PF13145.6 VDK79555.1 - 0.45 11.4 2.8 5.9 7.7 0.1 2.2 2 0 0 2 2 2 0 PPIC-type PPIASE domain TFIIA PF03153.13 VDK79555.1 - 3.5 7.5 7.9 3.9 7.4 7.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4127 PF13552.6 VDK79556.1 - 0.022 13.4 0.5 0.027 13.1 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) Usp PF00582.26 VDK79556.1 - 0.025 15.1 0.2 0.033 14.7 0.2 1.1 1 0 0 1 1 1 0 Universal stress protein family WD-3 PF09765.9 VDK79556.1 - 0.051 12.9 0.4 0.049 12.9 0.4 1.2 1 0 0 1 1 1 0 WD-repeat region DUF1515 PF07439.11 VDK79556.1 - 0.052 13.6 0.6 0.088 12.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) PSP PF04046.16 VDK79560.1 - 3.2e-15 55.7 0.1 6.2e-15 54.8 0.1 1.4 1 0 0 1 1 1 1 PSP TUDOR_5 PF18359.1 VDK79560.1 - 3.6e-07 29.8 0.1 2.6e-05 23.8 0.0 2.7 2 0 0 2 2 2 1 Histone methyltransferase Tudor domain 1 FBPase PF00316.20 VDK79560.1 - 0.0026 17.3 0.1 0.0054 16.2 0.1 1.4 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain DUF4537 PF15057.6 VDK79560.1 - 0.0036 17.3 0.1 0.013 15.5 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) TUDOR PF00567.24 VDK79560.1 - 0.11 12.5 0.1 0.33 11.0 0.1 1.7 1 0 0 1 1 1 0 Tudor domain PBP1_TM PF14812.6 VDK79560.1 - 1.7 9.0 5.6 6.7 7.2 4.8 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MA3 PF02847.17 VDK79567.1 - 1.8e-18 66.6 1.1 1.8e-18 66.6 1.1 3.3 3 1 1 4 4 4 1 MA3 domain MIF4G PF02854.19 VDK79567.1 - 0.0013 18.4 6.5 0.0013 18.4 6.5 2.5 2 0 0 2 2 2 1 MIF4G domain DUF3342 PF11822.8 VDK79567.1 - 0.081 13.1 0.1 0.35 11.1 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Pkinase PF00069.25 VDK79569.1 - 9.7e-66 221.8 0.0 1.3e-65 221.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK79569.1 - 4.2e-29 101.6 0.0 6.1e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 VDK79569.1 - 7.4e-19 67.6 3.6 2.3e-07 30.9 0.3 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK79569.1 - 1e-18 67.7 1.0 2.8e-08 34.2 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK79569.1 - 5e-18 65.2 0.7 7.2e-08 32.8 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK79569.1 - 5.7e-15 53.9 1.3 0.0063 16.9 0.0 5.3 5 0 0 5 5 4 3 Ankyrin repeat Ank PF00023.30 VDK79569.1 - 2.6e-12 46.6 1.3 0.14 12.7 0.0 5.0 4 0 0 4 4 4 4 Ankyrin repeat Kdo PF06293.14 VDK79569.1 - 2.1e-07 30.5 0.0 3.5e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK79569.1 - 1.5e-05 24.5 0.0 2.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK79569.1 - 4.1e-05 22.5 0.0 6.2e-05 21.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 VDK79569.1 - 0.0066 16.0 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 VDK79569.1 - 0.08 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ank_2 PF12796.7 VDK79574.1 - 8.6e-24 83.9 3.0 1.9e-14 54.0 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK79574.1 - 1.4e-18 66.7 3.3 1.1e-10 41.5 0.2 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 VDK79574.1 - 6.2e-17 61.2 6.9 2.3e-06 27.8 0.1 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 VDK79574.1 - 9e-17 61.2 1.3 3.2e-12 46.7 0.7 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK79574.1 - 3e-15 54.8 0.9 0.0002 21.5 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Death PF00531.22 VDK79575.1 - 1.4e-16 60.5 0.1 3.6e-16 59.1 0.1 1.8 1 0 0 1 1 1 1 Death domain Ank_4 PF13637.6 VDK79575.1 - 2.2e-06 28.1 0.1 7.7e-06 26.4 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK79575.1 - 3e-06 27.7 0.1 2.4e-05 24.8 0.2 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK79575.1 - 5.4e-06 26.6 0.1 1.5e-05 25.2 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Roc PF08477.13 VDK79575.1 - 4.4e-05 23.7 0.0 0.0074 16.5 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ank_3 PF13606.6 VDK79575.1 - 0.00024 21.3 0.3 0.0015 18.9 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 VDK79575.1 - 0.00039 20.7 0.1 0.001 19.4 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat COR PF16095.5 VDK79575.1 - 0.045 13.6 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain Arf PF00025.21 VDK79575.1 - 0.22 11.0 0.3 0.68 9.4 0.1 1.9 2 0 0 2 2 2 0 ADP-ribosylation factor family Innexin PF00876.18 VDK79577.1 - 8.4e-36 124.0 3.3 3.3e-31 108.9 2.2 3.0 2 1 0 2 2 2 2 Innexin LSM14 PF12701.7 VDK79578.1 - 7e-30 103.0 0.1 2.2e-29 101.4 0.0 1.9 2 0 0 2 2 2 1 Scd6-like Sm domain FDF PF09532.10 VDK79578.1 - 6.5e-16 59.1 9.3 1.6e-15 57.9 9.3 1.7 1 0 0 1 1 1 1 FDF domain SM-ATX PF14438.6 VDK79578.1 - 3e-08 33.7 0.0 5.8e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain zf-H2C2_5 PF13909.6 VDK79581.1 - 5.2e-05 22.9 11.7 0.00047 19.8 2.2 13.6 14 0 0 14 14 14 5 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 VDK79581.1 - 0.00091 19.6 16.3 0.0075 16.6 2.7 15.3 15 1 1 16 16 16 8 Zinc-finger double domain zf-C2H2_7 PF15269.6 VDK79581.1 - 0.0027 17.7 3.5 0.0027 17.7 3.5 9.5 8 4 4 12 12 12 2 Zinc-finger ICAT PF06384.11 VDK79597.1 - 1.2e-07 31.9 0.1 3.7e-07 30.3 0.0 1.9 2 1 0 2 2 2 1 Beta-catenin-interacting protein ICAT GvpG PF05120.12 VDK79597.1 - 0.041 13.9 0.5 0.041 13.9 0.5 2.3 2 1 0 2 2 2 0 Gas vesicle protein G BTB PF00651.31 VDK79598.1 - 1e-26 93.3 2.1 1.6e-25 89.5 0.7 2.3 1 1 1 2 2 2 2 BTB/POZ domain TERB2 PF15101.6 VDK79598.1 - 0.11 12.5 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TDP43_N PF18694.1 VDK79599.1 - 4.3e-22 77.7 0.0 7.8e-22 76.9 0.0 1.5 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain RRM_1 PF00076.22 VDK79599.1 - 1e-19 70.1 0.3 5e-16 58.3 0.2 2.6 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK79599.1 - 0.058 13.5 1.4 0.069 13.2 0.1 1.8 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 VDK79599.1 - 0.12 12.6 0.1 13 6.0 0.0 2.6 2 1 0 2 2 2 0 RNA recognition motif GRP PF07172.11 VDK79599.1 - 2.1 9.1 14.5 0.34 11.6 10.1 2.0 2 0 0 2 2 2 0 Glycine rich protein family NICE-3 PF07406.11 VDK79600.1 - 1.2e-38 132.9 0.3 1.5e-38 132.6 0.3 1.0 1 0 0 1 1 1 1 NICE-3 protein Bestrophin PF01062.21 VDK79602.1 - 5.8e-67 226.1 9.9 5e-65 219.8 9.9 2.0 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel GlnD_UR_UTase PF08335.11 VDK79602.1 - 0.012 15.7 0.2 0.022 14.9 0.2 1.4 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase Ras PF00071.22 VDK79603.1 - 3.3e-28 98.3 0.0 4.2e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK79603.1 - 5.9e-14 52.3 0.0 9.1e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK79603.1 - 8.8e-09 35.0 0.0 1.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK79603.1 - 3.4e-06 26.7 0.0 3.2e-05 23.6 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDK79603.1 - 7.3e-05 22.8 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDK79603.1 - 0.0015 18.4 0.0 0.029 14.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 VDK79603.1 - 0.0089 16.0 0.0 0.014 15.4 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain SRPRB PF09439.10 VDK79603.1 - 0.069 12.6 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NOG1 PF06858.14 VDK79603.1 - 0.1 12.4 0.2 0.46 10.3 0.2 2.2 2 1 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) AAA_16 PF13191.6 VDK79603.1 - 0.15 12.4 0.0 0.24 11.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ProRS-C_1 PF09180.11 VDK79604.1 - 5.8e-20 71.3 0.1 1.6e-19 69.8 0.1 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 VDK79604.1 - 4.6e-18 65.8 0.0 8.6e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 VDK79604.1 - 1e-16 60.8 0.0 2e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain Utp14 PF04615.13 VDK79605.1 - 5.2e-120 402.3 53.3 6.3e-120 402.0 53.3 1.1 1 0 0 1 1 1 1 Utp14 protein Malate_DH PF12434.8 VDK79605.1 - 0.21 11.6 2.6 1.2 9.2 2.6 2.3 1 0 0 1 1 1 0 Malate dehydrogenase enzyme zf-H2C2_2 PF13465.6 VDK79622.1 - 1e-19 70.0 12.0 3.3e-10 39.9 0.1 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 VDK79622.1 - 2.3e-14 52.9 21.3 5.2e-06 26.6 0.1 3.8 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK79622.1 - 3.8e-14 52.2 15.1 2.7e-05 24.6 0.2 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 VDK79622.1 - 1.4e-06 28.5 8.6 0.034 14.6 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK79622.1 - 4.1e-06 26.9 5.6 0.0035 17.6 0.1 3.3 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 VDK79622.1 - 9.1e-06 25.9 12.4 0.0002 21.6 3.3 2.3 1 1 2 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 VDK79622.1 - 1.6e-05 24.8 12.0 0.011 15.7 2.7 3.9 3 1 0 3 3 3 2 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 VDK79622.1 - 0.00025 21.4 3.8 0.014 15.8 0.0 3.5 3 1 0 3 3 3 1 Autophagy receptor zinc finger-C2H2 domain Zn-ribbon_8 PF09723.10 VDK79622.1 - 0.00052 20.1 5.0 0.37 10.9 0.5 2.6 2 1 0 2 2 2 2 Zinc ribbon domain zf-C2H2_11 PF16622.5 VDK79622.1 - 0.00061 19.5 11.8 0.16 11.8 4.4 3.3 3 0 0 3 3 3 2 zinc-finger C2H2-type zf_UBZ PF18439.1 VDK79622.1 - 0.003 17.1 5.1 0.36 10.4 0.1 3.3 3 0 0 3 3 3 1 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 VDK79622.1 - 0.004 17.2 6.0 1.2 9.2 0.1 3.2 3 0 0 3 3 3 2 XPA protein N-terminal zf-C2H2_3rep PF18868.1 VDK79622.1 - 0.0057 17.3 4.0 1.3 9.7 0.3 3.0 1 1 2 3 3 3 2 Zinc finger C2H2-type, 3 repeats Vitelline_membr PF10542.9 VDK79622.1 - 0.0087 15.9 0.5 0.024 14.5 0.5 1.7 1 0 0 1 1 1 1 Vitelline membrane cysteine-rich region zf-C2HC_2 PF13913.6 VDK79622.1 - 0.011 15.6 12.2 0.28 11.1 0.5 3.6 3 1 0 3 3 3 0 zinc-finger of a C2HC-type Zn_ribbon_SprT PF17283.2 VDK79622.1 - 0.012 15.5 6.6 2.6 8.0 5.5 2.9 1 1 1 2 2 2 0 SprT-like zinc ribbon domain GAGA PF09237.11 VDK79622.1 - 0.013 15.3 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 GAGA factor zf-C2H2_2 PF12756.7 VDK79622.1 - 0.018 15.4 8.7 1 9.7 1.2 2.8 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-AN1 PF01428.16 VDK79622.1 - 0.024 14.8 7.6 3.8 7.8 0.1 3.4 3 0 0 3 3 3 0 AN1-like Zinc finger zinc_ribbon_4 PF13717.6 VDK79622.1 - 0.041 13.8 8.3 4.8 7.2 0.8 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-HYPF PF07503.12 VDK79622.1 - 0.068 13.0 0.4 0.068 13.0 0.4 3.4 3 1 0 3 3 3 0 HypF finger zf-H2C2_5 PF13909.6 VDK79622.1 - 0.12 12.2 0.1 0.12 12.2 0.1 3.5 4 0 0 4 4 2 0 C2H2-type zinc-finger domain Prok-RING_1 PF14446.6 VDK79622.1 - 0.12 12.3 6.3 10 6.1 0.4 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 DUF2225 PF09986.9 VDK79622.1 - 0.14 11.8 4.3 2.3 7.9 0.1 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zinc_ribbon_15 PF17032.5 VDK79622.1 - 0.19 12.5 0.5 0.19 12.5 0.5 2.5 1 1 0 2 2 2 0 zinc-ribbon family DUF2256 PF10013.9 VDK79622.1 - 0.28 11.3 6.3 6.9 6.9 0.6 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Elf1 PF05129.13 VDK79622.1 - 0.28 11.2 8.1 0.15 12.1 0.9 2.5 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like HNH PF01844.23 VDK79622.1 - 0.4 10.9 4.7 11 6.3 0.1 3.2 3 0 0 3 3 3 0 HNH endonuclease LIM PF00412.22 VDK79622.1 - 1.1 9.6 12.0 14 6.0 3.5 3.2 1 1 2 3 3 3 0 LIM domain UBZ_FAAP20 PF15750.5 VDK79622.1 - 1.5 8.9 6.1 2.7 8.0 0.2 3.1 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger zf-C2HE PF16278.5 VDK79622.1 - 2.2 8.8 9.8 12 6.4 0.3 3.4 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_Tnp_IS1595 PF12760.7 VDK79622.1 - 7.6 6.6 10.6 3.6 7.6 3.9 2.5 1 1 1 2 2 2 0 Transposase zinc-ribbon domain TFIIS_C PF01096.18 VDK79622.1 - 8.7 6.3 9.4 15 5.5 0.1 3.2 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) LBP_BPI_CETP_C PF02886.17 VDK79623.1 - 5.8e-16 58.7 0.2 7.7e-10 38.6 0.0 3.2 3 1 1 4 4 4 2 LBP / BPI / CETP family, C-terminal domain YfhD PF14151.6 VDK79623.1 - 0.079 13.1 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 YfhD-like protein Helicase_C_2 PF13307.6 VDK79625.1 - 1.5e-54 184.7 0.0 3.8e-54 183.4 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 VDK79625.1 - 2.3e-41 141.3 1.7 2.3e-41 141.3 1.7 1.8 2 0 0 2 2 2 1 DEAD_2 ResIII PF04851.15 VDK79625.1 - 3.2e-05 24.0 0.8 0.0086 16.1 0.6 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 VDK79625.1 - 0.017 14.9 1.5 0.44 10.3 1.2 2.8 2 1 0 2 2 2 0 DEAD/DEAH box helicase PhoH PF02562.16 VDK79625.1 - 0.038 13.4 0.0 0.63 9.4 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 VDK79625.1 - 0.15 11.6 0.1 0.6 9.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK79625.1 - 0.21 11.9 1.9 26 5.1 0.0 3.2 2 1 0 2 2 2 0 AAA domain DUF3258 PF11646.8 VDK79625.1 - 0.48 10.6 4.2 2.7 8.2 2.1 2.8 2 0 0 2 2 2 0 Protein of unknown function DUF3258 Glyco_hydro_15 PF00723.21 VDK79626.1 - 7.4e-127 423.8 0.8 8.9e-127 423.6 0.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 E1_DerP2_DerF2 PF02221.15 VDK79627.1 - 4e-05 24.1 0.0 5.1e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 ML domain RINGv PF12906.7 VDK79636.1 - 0.012 15.8 4.6 0.025 14.7 4.6 1.6 1 0 0 1 1 1 0 RING-variant domain TAL_FSA PF00923.19 VDK79637.1 - 7.3e-89 297.9 0.0 8.1e-89 297.8 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase CLAG PF03805.13 VDK79637.1 - 0.093 10.3 0.1 0.12 10.0 0.1 1.2 1 0 0 1 1 1 0 Cytoadherence-linked asexual protein TFIID-18kDa PF02269.16 VDK79639.1 - 1.4e-13 50.7 0.0 3.1e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Pkinase PF00069.25 VDK79641.1 - 1.2e-63 215.0 0.0 1.7e-63 214.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK79641.1 - 1.5e-40 139.1 0.0 2.1e-40 138.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RL10P_insert PF17777.1 VDK79641.1 - 9.5e-24 83.2 0.0 2.3e-23 82.0 0.0 1.7 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 VDK79641.1 - 4.3e-23 81.3 0.2 7.8e-23 80.5 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 Haspin_kinase PF12330.8 VDK79641.1 - 0.0011 18.0 0.0 0.0017 17.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain CI-B14_5a PF07347.12 VDK79641.1 - 0.016 15.0 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Pkinase_fungal PF17667.1 VDK79641.1 - 0.025 13.4 0.0 0.059 12.1 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Kinase-like PF14531.6 VDK79641.1 - 0.053 12.8 0.0 0.35 10.2 0.0 2.0 2 0 0 2 2 2 0 Kinase-like CCSMST1 PF15013.6 VDK79642.1 - 0.043 14.0 0.3 0.12 12.5 0.3 1.8 1 1 0 1 1 1 0 CCSMST1 family DUF1768 PF08719.11 VDK79644.1 - 9.6e-29 100.7 0.0 2.2e-28 99.5 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1768) DUF468 PF04318.12 VDK79644.1 - 0.27 11.9 0.3 0.27 11.9 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF468) Glypican PF01153.19 VDK79646.1 - 0.00017 20.6 5.5 0.086 11.7 0.2 2.9 1 1 2 3 3 3 3 Glypican PH PF00169.29 VDK79651.1 - 3.2e-09 37.2 0.0 4.3e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 VDK79651.1 - 0.015 15.1 0.0 0.023 14.5 0.0 1.3 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 VDK79651.1 - 0.092 13.1 0.0 0.21 12.0 0.0 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain Dev_Cell_Death PF10539.9 VDK79651.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.6 2 0 0 2 2 2 0 Development and cell death domain Glyco_transf_41 PF13844.6 VDK79652.1 - 5e-220 730.8 0.0 7.7e-220 730.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 41 TPR_1 PF00515.28 VDK79652.1 - 8.3e-90 291.3 32.5 3.1e-08 33.1 0.0 14.1 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_11 PF13414.6 VDK79652.1 - 5.5e-79 259.6 47.5 7.9e-11 41.5 0.0 13.0 3 2 11 14 14 14 12 TPR repeat TPR_2 PF07719.17 VDK79652.1 - 2.6e-70 227.0 21.9 1.5e-06 27.8 0.1 13.4 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_17 PF13431.6 VDK79652.1 - 7.1e-60 195.2 35.0 1.6e-05 24.9 0.2 14.1 14 0 0 14 14 14 12 Tetratricopeptide repeat TPR_8 PF13181.6 VDK79652.1 - 1.2e-59 193.6 19.0 6e-05 22.9 0.2 13.0 13 0 0 13 13 12 12 Tetratricopeptide repeat TPR_16 PF13432.6 VDK79652.1 - 3.7e-45 152.3 3.4 3e-08 34.2 0.1 8.3 6 1 2 8 8 8 8 Tetratricopeptide repeat TPR_19 PF14559.6 VDK79652.1 - 2.1e-42 143.5 23.1 8.6e-07 29.4 0.2 8.5 3 2 5 9 9 9 9 Tetratricopeptide repeat TPR_14 PF13428.6 VDK79652.1 - 5.5e-42 138.8 7.8 0.0059 17.3 0.0 13.2 4 3 9 13 13 13 10 Tetratricopeptide repeat TPR_12 PF13424.6 VDK79652.1 - 7.6e-42 141.5 27.2 5e-11 42.7 1.6 9.5 4 3 4 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 VDK79652.1 - 1.9e-34 116.6 41.4 1.1e-05 25.1 0.1 12.3 12 0 0 12 12 12 9 Tetratricopeptide repeat TPR_7 PF13176.6 VDK79652.1 - 2e-31 105.7 12.3 0.00091 19.1 0.0 12.4 13 0 0 13 13 12 8 Tetratricopeptide repeat TPR_9 PF13371.6 VDK79652.1 - 5.1e-15 55.4 3.7 0.18 11.9 0.0 6.5 3 2 4 7 7 7 4 Tetratricopeptide repeat NARP1 PF12569.8 VDK79652.1 - 2.1e-12 46.7 5.3 0.0046 15.9 0.2 5.3 2 2 1 5 5 5 4 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 VDK79652.1 - 7.6e-12 45.1 13.6 0.9 10.3 0.0 10.5 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK79652.1 - 4.8e-10 39.3 9.5 0.0011 18.5 0.1 4.8 1 1 2 4 4 4 4 MalT-like TPR region TPR_4 PF07721.14 VDK79652.1 - 6.1e-09 35.7 3.7 0.22 12.2 0.2 8.2 9 0 0 9 9 7 1 Tetratricopeptide repeat FAT PF02259.23 VDK79652.1 - 4.4e-08 32.7 1.3 0.65 9.1 0.2 6.4 2 2 4 7 7 7 1 FAT domain EST1_DNA_bind PF10373.9 VDK79652.1 - 1.2e-06 28.2 7.1 0.011 15.2 0.1 4.1 3 1 1 4 4 4 3 Est1 DNA/RNA binding domain TPR_15 PF13429.6 VDK79652.1 - 6.2e-06 25.6 3.5 0.53 9.4 0.1 4.1 1 1 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 VDK79652.1 - 0.0018 18.7 2.9 4.6 7.7 0.1 4.2 2 2 1 4 4 4 1 Bacterial transcriptional activator domain TPR_3 PF07720.12 VDK79652.1 - 0.0023 17.9 12.2 0.64 10.1 0.2 5.7 7 0 0 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK79652.1 - 0.0026 17.9 13.7 0.43 10.8 3.7 4.5 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 VDK79652.1 - 0.0095 15.7 19.7 3.8 7.2 4.7 5.4 2 1 1 4 4 4 1 Tetratricopeptide repeat-like domain FAM72 PF14976.6 VDK79652.1 - 0.035 14.2 0.9 0.083 13.0 0.9 1.5 1 0 0 1 1 1 0 FAM72 protein MIT PF04212.18 VDK79652.1 - 0.085 12.9 20.4 9.8 6.3 0.3 8.1 8 1 0 8 8 7 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 VDK79652.1 - 0.093 12.4 7.5 8.5 6.0 0.1 4.9 2 1 4 6 6 6 0 26S proteasome subunit RPN7 TOM20_plant PF06552.12 VDK79652.1 - 0.17 11.6 2.9 7.6 6.2 0.0 3.9 3 1 2 5 5 5 0 Plant specific mitochondrial import receptor subunit TOM20 Mad3_BUB1_I PF08311.12 VDK79652.1 - 0.45 10.5 8.9 28 4.7 0.2 5.7 7 0 0 7 7 6 0 Mad3/BUB1 homology region 1 SHNi-TPR PF10516.9 VDK79652.1 - 1.3 8.6 9.9 17 5.0 0.0 6.0 8 0 0 8 8 8 0 SHNi-TPR Alkyl_sulf_dimr PF14863.6 VDK79652.1 - 1.5 9.3 4.1 6.3 7.3 0.2 3.1 2 1 1 3 3 3 0 Alkyl sulfatase dimerisation TPR_20 PF14561.6 VDK79652.1 - 1.8 8.9 18.3 41 4.6 2.6 6.6 5 2 3 8 8 8 0 Tetratricopeptide repeat DUF5132 PF17195.4 VDK79653.1 - 0.082 13.0 0.5 0.21 11.7 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF5132) S1 PF00575.23 VDK79654.1 - 1.1e-23 83.3 13.0 6.7e-08 32.8 0.1 10.7 11 1 1 12 12 11 5 S1 RNA binding domain Suf PF05843.14 VDK79654.1 - 3.8e-14 53.4 8.9 6.4e-06 26.4 0.6 3.5 1 1 2 3 3 3 3 Suppressor of forked protein (Suf) TPR_15 PF13429.6 VDK79654.1 - 1.8e-06 27.4 1.2 0.0019 17.5 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK79654.1 - 9.4e-06 26.1 0.0 0.0039 17.7 0.0 3.8 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK79654.1 - 0.00072 20.2 0.1 11 7.1 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK79654.1 - 0.0059 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 MalT-like TPR region PPR PF01535.20 VDK79654.1 - 0.011 15.9 0.2 11 6.6 0.0 3.4 3 0 0 3 3 3 0 PPR repeat TPR_17 PF13431.6 VDK79654.1 - 0.011 16.0 0.0 16 6.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR_2 PF13041.6 VDK79654.1 - 0.017 15.3 0.7 10 6.4 0.0 3.7 3 1 0 3 3 3 0 PPR repeat family TPR_16 PF13432.6 VDK79654.1 - 0.021 15.5 0.0 15 6.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 VDK79654.1 - 0.031 14.4 1.7 5.1 7.5 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK79654.1 - 0.14 12.5 4.6 4.7 7.7 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK79654.1 - 0.16 12.2 0.1 3.3 8.0 0.0 2.7 2 1 1 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 CsrA PF02599.16 VDK79654.1 - 0.47 10.4 6.7 6.3 6.8 0.1 4.0 3 0 0 3 3 3 0 Global regulator protein family DUF2187 PF09953.9 VDK79654.1 - 0.58 10.2 11.1 13 5.9 0.0 5.0 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2187) TPR_6 PF13174.6 VDK79654.1 - 1.5 9.6 0.0 1.5 9.6 0.0 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat G-gamma PF00631.22 VDK79656.1 - 5.9e-11 42.2 0.1 7.4e-11 41.9 0.1 1.2 1 0 0 1 1 1 1 GGL domain YebO PF13974.6 VDK79656.1 - 0.038 14.1 0.1 0.042 13.9 0.1 1.2 1 0 0 1 1 1 0 YebO-like protein FaeA PF04703.12 VDK79656.1 - 0.092 13.1 0.1 0.12 12.7 0.1 1.2 1 0 0 1 1 1 0 FaeA-like protein DEAD PF00270.29 VDK79657.1 - 4.3e-37 127.6 0.4 1.6e-36 125.7 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK79657.1 - 3e-19 69.4 1.3 2.3e-18 66.5 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 VDK79657.1 - 2.3e-15 56.6 0.0 7.8e-15 54.8 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 VDK79657.1 - 1.2e-10 41.6 1.2 1.9e-09 37.7 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 VDK79657.1 - 0.0043 17.2 0.1 0.0043 17.2 0.1 2.5 4 0 0 4 4 4 1 Helicase C-terminal domain AAA_19 PF13245.6 VDK79657.1 - 0.036 14.4 0.0 0.14 12.5 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 VDK79657.1 - 0.061 13.0 0.0 0.17 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain GAGA_bind PF06217.12 VDK79657.1 - 0.11 12.7 2.4 0.21 11.8 2.4 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_22 PF13401.6 VDK79657.1 - 0.12 12.6 0.1 5.2 7.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain UL42 PF17638.2 VDK79659.1 - 0.034 14.1 0.0 0.04 13.9 0.0 1.1 1 0 0 1 1 1 0 HCMV UL42 GYF PF02213.16 VDK79662.1 - 4.6e-05 23.0 0.1 0.00013 21.6 0.1 1.8 1 0 0 1 1 1 1 GYF domain Arf PF00025.21 VDK79663.1 - 1.5e-36 125.5 0.4 1.6e-36 125.3 0.4 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK79663.1 - 1.2e-09 38.4 0.1 1.5e-09 38.1 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 VDK79663.1 - 2.7e-08 33.4 0.8 3.4e-05 23.2 0.1 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 VDK79663.1 - 7.3e-08 32.2 0.0 8.1e-08 32.0 0.0 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 VDK79663.1 - 1.9e-06 27.4 0.0 1.9e-06 27.4 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 VDK79663.1 - 3.7e-05 23.2 0.0 3.9e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK79663.1 - 0.01 15.9 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase 6PF2K PF01591.18 VDK79663.1 - 0.011 15.0 0.1 0.011 15.0 0.1 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_33 PF13671.6 VDK79663.1 - 0.13 12.4 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 VDK79663.1 - 0.15 11.7 0.2 0.19 11.3 0.2 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain zf-RING_6 PF14835.6 VDK79684.1 - 0.089 12.7 3.5 0.22 11.4 3.5 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Metallophos PF00149.28 VDK79685.1 - 2.1e-35 123.1 0.0 3e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK79685.1 - 1.9e-11 44.2 0.4 3.6e-11 43.3 0.4 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain SF3b10 PF07189.11 VDK79686.1 - 0.11 12.6 0.0 0.33 11.1 0.0 1.8 2 0 0 2 2 2 0 Splicing factor 3B subunit 10 (SF3b10) DUF2358 PF10184.9 VDK79687.1 - 1.9e-11 44.2 0.1 2.5e-11 43.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2358) SnoaL_2 PF12680.7 VDK79687.1 - 5.5e-05 23.8 0.0 8.4e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 SnoaL-like domain zf-CCCH PF00642.24 VDK79693.1 - 2.9e-05 23.9 3.7 0.00048 20.0 0.5 2.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 VDK79693.1 - 0.0016 18.2 6.0 0.068 13.0 0.3 2.8 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 VDK79693.1 - 0.006 17.0 5.8 0.36 11.4 0.4 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Antifungal_prot PF11402.8 VDK79693.1 - 0.3 11.3 4.7 1.5 9.1 4.7 2.1 1 1 0 1 1 1 0 Antifungal protein zf_CCCH_4 PF18345.1 VDK79693.1 - 1.1 9.5 9.9 4.9 7.3 2.0 3.6 2 2 0 2 2 2 0 Zinc finger domain Motile_Sperm PF00635.26 VDK79704.1 - 3.5e-19 68.6 2.5 3.5e-19 68.6 2.5 2.1 2 0 0 2 2 2 1 MSP (Major sperm protein) domain CDC27 PF09507.10 VDK79704.1 - 6.4 6.1 51.2 8.3 5.7 51.2 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 VDK79704.1 - 6.4 5.4 24.8 8.7 5.0 24.8 1.2 1 0 0 1 1 1 0 Presenilin DEAD PF00270.29 VDK79705.1 - 9.9e-38 129.6 0.0 2.4e-36 125.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK79705.1 - 6.6e-27 94.1 0.0 3.3e-26 91.8 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK79705.1 - 0.01 15.9 0.0 0.028 14.4 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Bestrophin PF01062.21 VDK79706.1 - 1.1e-68 231.8 5.6 1.5e-68 231.4 5.6 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DB PF01682.19 VDK79706.1 - 1.2e-15 57.6 7.8 1.2e-15 57.6 7.8 2.3 2 1 1 3 3 3 1 DB module Innexin PF00876.18 VDK79708.1 - 4.1e-112 375.0 9.3 5e-112 374.7 9.3 1.1 1 0 0 1 1 1 1 Innexin Glycos_transf_2 PF00535.26 VDK79709.1 - 1.3e-30 106.4 0.0 2.5e-30 105.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 VDK79709.1 - 1.8e-15 57.3 0.8 2.9e-15 56.6 0.8 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_tranf_2_3 PF13641.6 VDK79709.1 - 1.1e-06 28.7 0.0 2e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 VDK79709.1 - 4.9e-05 22.9 0.0 0.00016 21.3 0.0 1.9 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_7C PF02709.14 VDK79709.1 - 0.00027 20.5 0.1 0.00056 19.5 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase MYEOV2 PF15004.6 VDK79709.1 - 0.00044 20.6 4.5 0.00084 19.7 3.6 1.9 2 0 0 2 2 2 1 Myeloma-overexpressed-like adh_short PF00106.25 VDK79710.1 - 5.1e-27 94.6 0.0 4.4e-25 88.3 0.0 2.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK79710.1 - 3.4e-14 53.0 0.0 4.1e-07 29.8 0.0 2.9 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK79710.1 - 0.02 14.8 0.2 0.032 14.2 0.2 1.2 1 0 0 1 1 1 0 KR domain Epimerase PF01370.21 VDK79710.1 - 0.06 12.8 0.0 0.28 10.6 0.0 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Ald_Xan_dh_C PF01315.22 VDK79710.1 - 0.15 12.5 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain zf-C3HC4_3 PF13920.6 VDK79713.1 - 4.3e-08 32.9 7.9 4.3e-08 32.9 7.9 2.9 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) AIP3 PF03915.13 VDK79713.1 - 2.3e-07 30.3 10.9 2.3e-07 30.3 10.9 2.2 2 0 0 2 2 2 1 Actin interacting protein 3 zf-RING_UBOX PF13445.6 VDK79713.1 - 4.8e-06 26.5 10.5 2.3e-05 24.3 10.5 2.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDK79713.1 - 6.8e-05 22.6 10.8 6.8e-05 22.6 10.8 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK79713.1 - 8.3e-05 22.8 10.7 8.3e-05 22.8 10.7 3.4 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 VDK79713.1 - 0.00011 22.1 10.1 0.00011 22.1 10.1 3.2 4 0 0 4 4 4 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK79713.1 - 0.0029 17.4 11.3 0.0029 17.4 11.3 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 VDK79713.1 - 0.0042 17.2 7.3 0.0042 17.2 7.3 3.6 3 1 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 VDK79713.1 - 0.0049 16.7 11.5 0.0049 16.7 11.5 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF2321 PF10083.9 VDK79713.1 - 0.059 13.0 4.8 0.045 13.4 1.9 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) AAA_13 PF13166.6 VDK79713.1 - 0.16 10.5 16.4 0.019 13.6 5.4 2.6 2 1 0 2 2 2 0 AAA domain Cript PF10235.9 VDK79713.1 - 0.79 10.3 8.5 0.081 13.5 1.7 3.0 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT EMP24_GP25L PF01105.24 VDK79714.1 - 2.7e-48 164.3 0.2 3.1e-48 164.1 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_Mx1 PF15890.5 VDK79714.1 - 0.044 13.2 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase Chitin_bind_4 PF00379.23 VDK79714.1 - 0.057 14.0 0.2 0.17 12.4 0.0 1.9 2 0 0 2 2 2 0 Insect cuticle protein Yip1 PF04893.17 VDK79716.1 - 4.5e-11 42.8 23.8 7.3e-11 42.1 23.3 1.6 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 VDK79716.1 - 1.1 9.0 11.2 1.6 8.5 11.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) DHHC PF01529.20 VDK79726.1 - 1.6e-25 89.7 18.1 3e-25 88.9 18.1 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase Ndc80_HEC PF03801.13 VDK79728.1 - 2.6e-34 118.1 0.0 7.3e-34 116.6 0.0 1.8 1 0 0 1 1 1 1 HEC/Ndc80p family DUF5595 PF18077.1 VDK79728.1 - 0.013 15.5 0.6 0.013 15.5 0.6 4.7 3 1 1 4 4 4 0 Domain of unknown function (DUF5595) YvrJ PF12841.7 VDK79728.1 - 0.31 10.6 0.8 5.2 6.7 0.1 2.7 2 0 0 2 2 2 0 YvrJ protein family Baculo_PEP_C PF04513.12 VDK79728.1 - 0.52 10.4 20.8 2.9 7.9 0.1 3.6 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3450 PF11932.8 VDK79728.1 - 3.1 7.1 37.7 3.4 6.9 4.0 3.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF948 PF06103.11 VDK79728.1 - 8.6 6.7 6.3 8.5 6.7 0.0 3.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) S4 PF01479.25 VDK79730.1 - 0.00096 18.8 0.3 0.0018 18.0 0.3 1.5 1 0 0 1 1 1 1 S4 domain Lactamase_B_6 PF16661.5 VDK79733.1 - 2.7e-10 40.0 0.0 2.1e-09 37.1 0.0 2.3 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 VDK79733.1 - 3.2e-10 40.3 0.0 6.7e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Beta_lactamase3 PF17030.5 VDK79733.1 - 0.00075 18.8 0.1 0.0023 17.2 0.1 1.9 1 1 0 1 1 1 1 Putative beta-lactamase-like family Epimerase PF01370.21 VDK79735.1 - 7.5e-21 74.7 0.0 1.2e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 VDK79735.1 - 8.8e-17 61.0 0.0 1.4e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 VDK79735.1 - 2.1e-12 47.3 0.0 3.2e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 VDK79735.1 - 4.1e-11 42.9 0.0 5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 VDK79735.1 - 4.5e-10 39.1 0.0 1.1e-09 37.9 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 VDK79735.1 - 2.7e-05 23.9 0.0 4.9e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 VDK79735.1 - 0.00073 19.0 0.0 0.0016 17.9 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 VDK79735.1 - 0.0076 16.2 0.0 0.049 13.5 0.0 2.1 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 VDK79735.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein SLAC1 PF03595.17 VDK79737.1 - 0.015 14.6 0.7 0.02 14.2 0.7 1.1 1 0 0 1 1 1 0 Voltage-dependent anion channel Fibrinogen_C PF00147.18 VDK79739.1 - 5e-46 157.3 8.3 6.7e-46 156.8 8.3 1.2 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4859 PF16151.5 VDK79739.1 - 0.043 13.7 1.1 2.6 7.9 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4859) FSA_C PF10479.9 VDK79739.1 - 0.67 8.0 5.0 0.93 7.5 5.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Glyco_hydro_38N PF01074.22 VDK79741.1 - 9.1e-74 248.4 0.6 1.4e-73 247.8 0.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 VDK79741.1 - 1.7e-26 92.2 0.8 3.8e-26 91.1 0.8 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 VDK79741.1 - 1e-23 84.5 0.2 3.3e-23 82.9 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain C2 PF00168.30 VDK79749.1 - 2.1e-52 175.7 0.1 1.6e-25 89.4 0.0 2.2 2 0 0 2 2 2 2 C2 domain PTEN_C2 PF10409.9 VDK79749.1 - 0.00069 19.4 0.4 0.41 10.4 0.1 2.9 2 1 1 3 3 3 2 C2 domain of PTEN tumour-suppressor protein PI3K_C2 PF00792.24 VDK79749.1 - 0.0039 17.1 0.1 0.014 15.3 0.0 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 Toxin_27 PF08099.11 VDK79749.1 - 0.0048 17.0 0.7 0.01 15.9 0.7 1.6 1 0 0 1 1 1 1 Scorpion calcine family DOCK-C2 PF14429.6 VDK79749.1 - 0.0057 16.5 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins RIH_assoc PF08454.11 VDK79750.1 - 9.6e-24 83.2 1.6 7.3e-23 80.3 0.0 3.4 3 0 0 3 3 3 1 RyR and IP3R Homology associated RR_TM4-6 PF06459.12 VDK79750.1 - 2.9e-19 70.0 0.0 2.9e-19 70.0 0.0 2.4 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 Ion_trans PF00520.31 VDK79750.1 - 1.1e-15 57.5 4.8 1.1e-15 57.5 4.8 2.5 3 0 0 3 3 3 1 Ion transport protein EF-hand_7 PF13499.6 VDK79750.1 - 6.9e-11 42.4 0.4 3.1e-10 40.4 0.4 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 VDK79750.1 - 6.1e-09 35.0 0.1 0.00014 21.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 VDK79750.1 - 8.2e-09 34.4 0.2 0.00085 18.7 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 VDK79750.1 - 6.5e-08 32.3 2.2 9.2e-08 31.8 0.3 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK79750.1 - 1.5e-06 27.6 2.7 0.00019 21.1 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain SPARC_Ca_bdg PF10591.9 VDK79750.1 - 0.043 14.1 0.9 0.16 12.3 0.9 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region RYDR_ITPR PF01365.21 VDK79751.1 - 5.5e-118 391.6 15.7 4.7e-69 231.9 0.3 4.0 4 0 0 4 4 4 2 RIH domain RyR PF02026.16 VDK79751.1 - 4.4e-105 344.1 0.7 2.7e-27 94.8 0.1 5.9 5 0 0 5 5 5 4 RyR domain SPRY PF00622.28 VDK79751.1 - 1.7e-55 186.3 2.2 1.7e-18 66.9 0.2 3.7 3 0 0 3 3 3 3 SPRY domain Ins145_P3_rec PF08709.11 VDK79751.1 - 3.5e-51 173.4 0.0 1.1e-50 171.8 0.1 1.9 2 0 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 VDK79751.1 - 9.7e-50 169.0 0.2 5.5e-44 150.2 0.0 2.7 2 0 0 2 2 2 2 MIR domain Ish1 PF10281.9 VDK79752.1 - 0.0072 16.6 0.0 0.025 14.9 0.0 2.0 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein Slx4 PF09494.10 VDK79752.1 - 0.017 15.1 0.0 0.062 13.3 0.0 2.0 1 0 0 1 1 1 0 Slx4 endonuclease LEM PF03020.15 VDK79752.1 - 0.029 14.0 0.0 0.095 12.3 0.0 2.0 1 1 0 1 1 1 0 LEM domain SAP PF02037.27 VDK79752.1 - 0.037 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 SAP domain TLC PF03219.14 VDK79771.1 - 0.39 9.4 9.8 0.5 9.0 9.8 1.1 1 0 0 1 1 1 0 TLC ATP/ADP transporter zf-RING_2 PF13639.6 VDK79772.1 - 1.6e-11 44.4 7.3 3.3e-11 43.3 7.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 VDK79772.1 - 6e-08 32.9 10.0 2.5e-07 30.9 10.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 VDK79772.1 - 5.8e-07 29.3 6.9 1.6e-06 27.8 6.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK79772.1 - 7.2e-07 29.1 2.8 1.7e-06 27.9 2.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDK79772.1 - 1.1e-06 28.4 6.6 2.2e-06 27.4 6.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 VDK79772.1 - 6.9e-06 25.7 2.6 1.5e-05 24.6 2.6 1.6 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 VDK79772.1 - 7.1e-06 25.6 2.9 1.5e-05 24.5 2.9 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 VDK79772.1 - 1.1e-05 25.1 6.2 3.7e-05 23.5 6.3 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK79772.1 - 4.7e-05 23.2 6.9 9.9e-05 22.2 6.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK79772.1 - 0.00015 21.5 4.3 0.00035 20.4 4.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 VDK79772.1 - 0.0033 17.4 4.9 0.011 15.7 4.9 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 VDK79772.1 - 0.017 15.3 2.5 0.041 14.0 2.5 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H PF13771.6 VDK79772.1 - 0.02 15.1 2.3 0.047 13.9 2.3 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING-like PF08746.11 VDK79772.1 - 0.052 13.9 6.7 0.1 12.9 6.7 1.5 1 0 0 1 1 1 0 RING-like domain zf-RING_6 PF14835.6 VDK79772.1 - 0.097 12.6 0.4 0.23 11.3 0.4 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RINGv PF12906.7 VDK79772.1 - 0.23 11.6 7.2 0.53 10.5 7.2 1.6 1 0 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 VDK79772.1 - 0.4 10.8 3.6 0.52 10.5 2.1 1.9 2 0 0 2 2 2 0 KIAA1045 RING finger zf-C3H2C3 PF17122.5 VDK79772.1 - 0.93 9.6 5.9 0.18 11.9 2.0 1.8 2 0 0 2 2 1 0 Zinc-finger zf-RING_4 PF14570.6 VDK79772.1 - 1.3 8.9 4.5 2.5 7.9 4.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain SNARE PF05739.19 VDK79774.1 - 3.2e-16 59.0 0.1 3.2e-16 59.0 0.1 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin-5_N PF11416.8 VDK79774.1 - 8.7e-05 21.6 0.1 0.00024 20.2 0.1 1.8 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain DUF1640 PF07798.11 VDK79774.1 - 0.0069 16.5 6.9 0.022 14.8 0.1 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF1640) SEO_N PF14576.6 VDK79774.1 - 0.21 10.7 5.0 0.13 11.4 0.2 2.5 2 1 0 2 2 2 0 Sieve element occlusion N-terminus EF-hand_7 PF13499.6 VDK79777.1 - 1.2e-07 32.1 1.6 2.3e-07 31.2 1.5 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK79777.1 - 7.4e-05 22.4 4.8 0.027 14.4 0.4 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 VDK79777.1 - 0.00013 21.2 1.1 0.028 13.9 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 VDK79777.1 - 0.004 17.1 0.4 0.97 9.4 0.1 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDK79777.1 - 0.0067 16.7 3.4 1.4 9.3 0.6 2.7 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 VDK79777.1 - 0.017 14.9 0.1 0.14 12.0 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 VDK79777.1 - 0.033 13.7 0.8 0.065 12.7 0.1 1.8 2 0 0 2 2 2 0 EF hand Aldo_ket_red PF00248.21 VDK79779.1 - 0.032 13.4 0.0 0.034 13.3 0.0 1.1 1 0 0 1 1 1 0 Aldo/keto reductase family AlkA_N PF06029.11 VDK79779.1 - 0.063 13.6 0.2 0.072 13.4 0.2 1.1 1 0 0 1 1 1 0 AlkA N-terminal domain Pox_MCEL PF03291.16 VDK79781.1 - 7.1e-88 294.9 0.0 8.7e-88 294.6 0.0 1.0 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 VDK79781.1 - 1e-12 48.6 0.0 2.5e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK79781.1 - 5.1e-09 36.7 0.0 1.1e-08 35.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK79781.1 - 9.7e-07 28.7 0.1 8.3e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK79781.1 - 5.5e-06 26.3 0.0 9.3e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK79781.1 - 9.6e-05 23.1 0.0 0.0002 22.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 VDK79781.1 - 0.0035 17.5 0.0 0.0076 16.4 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 VDK79781.1 - 0.01 15.2 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 VDK79781.1 - 0.018 14.2 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family MTS PF05175.14 VDK79781.1 - 0.037 13.6 0.0 0.32 10.5 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase small domain zf-CCCH PF00642.24 VDK79784.1 - 0.00022 21.1 2.8 0.00047 20.0 2.8 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 VDK79784.1 - 0.0051 16.6 2.2 0.013 15.2 1.8 1.9 2 0 0 2 2 2 1 CCCH-type zinc finger DUF3331 PF11811.8 VDK79784.1 - 0.037 13.9 0.4 0.15 12.0 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3331) zf_CCCH_4 PF18345.1 VDK79784.1 - 0.091 12.9 4.7 0.091 12.9 4.7 2.2 2 0 0 2 2 2 0 Zinc finger domain PI-PLC-X PF00388.19 VDK79797.1 - 1.9e-35 121.6 0.0 6.2e-35 119.9 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 VDK79797.1 - 6.8e-21 74.8 0.3 3.5e-20 72.5 0.3 2.2 1 1 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 VDK79797.1 - 2.6e-18 66.2 0.0 6.7e-18 64.9 0.0 1.7 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 VDK79797.1 - 2.8e-15 56.5 0.5 8.6e-15 55.0 0.2 2.0 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like PH_12 PF16457.5 VDK79797.1 - 2e-13 51.0 1.7 2.3e-13 50.8 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain PH_14 PF17787.1 VDK79797.1 - 6.4e-06 26.1 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 PH domain PH PF00169.29 VDK79797.1 - 0.031 14.8 0.3 0.22 12.1 0.1 2.5 2 0 0 2 2 2 0 PH domain EF-hand_7 PF13499.6 VDK79797.1 - 0.034 14.6 0.0 0.18 12.3 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair Elicitin PF00964.17 VDK79797.1 - 0.048 13.8 4.7 0.14 12.3 0.6 3.5 3 0 0 3 3 3 0 Elicitin Mcp5_PH PF12814.7 VDK79797.1 - 0.06 13.5 0.3 0.15 12.2 0.3 1.7 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Ras PF00071.22 VDK79798.1 - 7.3e-53 178.5 0.0 9.4e-53 178.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK79798.1 - 1.5e-36 125.2 0.0 2.5e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK79798.1 - 4.6e-14 52.3 0.0 6e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK79798.1 - 2.8e-07 30.1 0.0 3.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK79798.1 - 2.6e-06 27.5 0.0 4.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 VDK79798.1 - 2.5e-05 23.9 0.0 0.00011 21.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 VDK79798.1 - 9.2e-05 22.0 0.0 0.00014 21.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 VDK79798.1 - 0.00095 19.0 0.5 0.15 11.8 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein NACHT PF05729.12 VDK79798.1 - 0.013 15.5 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 VDK79798.1 - 0.016 15.1 0.1 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 VDK79798.1 - 0.017 15.5 0.1 0.025 15.0 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 VDK79798.1 - 0.022 14.3 0.2 0.044 13.3 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 VDK79798.1 - 0.023 14.7 0.1 0.05 13.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 VDK79798.1 - 0.027 14.9 0.0 0.075 13.5 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 VDK79798.1 - 0.035 14.1 0.1 0.11 12.5 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FeoB_N PF02421.18 VDK79798.1 - 0.041 13.4 0.1 0.13 11.8 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 VDK79798.1 - 0.048 13.4 0.1 0.21 11.3 0.1 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 VDK79798.1 - 0.06 13.6 0.0 0.21 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 VDK79798.1 - 0.062 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Septin Glyco_hydro_18 PF00704.28 VDK79799.1 - 2.1e-20 73.7 0.0 2.7e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 CarboxypepD_reg PF13620.6 VDK79801.1 - 1.5e-40 137.4 1.2 8.8e-08 32.3 0.0 9.3 8 1 0 8 8 8 8 Carboxypeptidase regulatory-like domain Cation_efflux PF01545.21 VDK79801.1 - 4.6e-36 124.4 25.4 7.5e-36 123.7 25.4 1.3 1 0 0 1 1 1 1 Cation efflux family SdrD_B PF17210.3 VDK79801.1 - 5.3e-22 78.2 6.6 0.0097 16.1 0.0 9.1 7 2 2 9 9 9 6 SdrD B-like domain SpaA PF17802.1 VDK79801.1 - 6.9e-12 45.5 2.6 0.022 15.1 0.0 7.2 4 2 2 7 7 7 2 Prealbumin-like fold domain bMG3 PF11974.8 VDK79801.1 - 8.5e-10 38.6 0.1 0.84 9.7 0.0 7.1 7 1 0 7 7 7 3 Bacterial alpha-2-macroglobulin MG3 domain CarbopepD_reg_2 PF13715.6 VDK79801.1 - 6.3e-09 35.7 6.4 0.054 13.5 0.1 7.9 9 0 0 9 9 9 3 CarboxypepD_reg-like domain DUF2012 PF09430.10 VDK79801.1 - 1.6e-07 31.5 0.1 0.028 14.5 0.1 4.0 4 0 0 4 4 4 2 Protein of unknown function (DUF2012) DUF4198 PF10670.9 VDK79801.1 - 2.6e-06 28.0 0.0 0.59 10.5 0.0 5.3 5 1 0 6 6 6 1 Domain of unknown function (DUF4198) DUF1416 PF07210.12 VDK79801.1 - 0.0035 17.2 0.0 0.14 12.0 0.0 3.6 4 0 0 4 4 4 1 Protein of unknown function (DUF1416) Big_1 PF02369.16 VDK79801.1 - 0.11 12.5 9.4 0.99 9.5 0.0 5.8 8 0 0 8 8 8 0 Bacterial Ig-like domain (group 1) CLU PF13236.6 VDK79802.1 - 6.3e-80 268.1 0.0 3.9e-79 265.6 0.0 2.1 1 1 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 VDK79802.1 - 2.3e-49 167.8 0.0 6.8e-49 166.3 0.0 1.9 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 VDK79802.1 - 5.4e-17 61.9 6.0 7e-11 42.3 0.3 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat CLU_N PF15044.6 VDK79802.1 - 3.7e-12 46.4 0.7 3.8e-06 27.2 0.0 2.8 2 0 0 2 2 2 2 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 VDK79802.1 - 3.7e-06 26.6 6.0 0.063 13.2 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK79802.1 - 2.9e-05 23.6 4.5 0.00014 21.4 4.2 1.9 1 1 0 1 1 1 1 MalT-like TPR region DUF727 PF05303.12 VDK79802.1 - 0.00021 21.3 0.0 0.00093 19.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF727) TPR_2 PF07719.17 VDK79802.1 - 0.00027 20.8 1.0 0.086 13.0 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDK79802.1 - 0.0015 18.3 0.4 0.0098 15.7 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 VDK79802.1 - 0.0018 18.2 0.1 4.5 7.5 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat Tom37_C PF11801.8 VDK79802.1 - 0.16 11.9 0.3 0.43 10.5 0.1 1.7 2 0 0 2 2 2 0 Tom37 C-terminal domain Ground-like PF04155.18 VDK79811.1 - 1.3e-17 64.2 0.1 2.5e-17 63.3 0.1 1.5 1 0 0 1 1 1 1 Ground-like domain zf-rbx1 PF12678.7 VDK79813.1 - 5.5e-21 74.6 16.7 8.5e-21 74.0 16.7 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 VDK79813.1 - 1.6e-17 63.4 14.1 2.2e-17 62.9 14.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 VDK79813.1 - 1.2e-07 32.0 12.9 1.2e-07 32.0 12.9 2.2 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK79813.1 - 0.00096 19.0 12.9 0.00096 19.0 12.9 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK79813.1 - 0.018 14.9 17.9 0.092 12.6 17.9 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK79813.1 - 1.3 9.1 19.6 8.6 6.4 19.9 2.1 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 VDK79813.1 - 1.3 9.0 21.3 0.097 12.5 12.7 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 VDK79813.1 - 4.9 7.2 19.5 47 4.0 0.1 3.0 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 ACOX PF01756.19 VDK79814.1 - 2.7e-49 167.2 0.1 4.4e-49 166.5 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 VDK79814.1 - 8.9e-28 97.3 0.0 3e-27 95.6 0.0 2.0 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 VDK79814.1 - 1e-12 48.1 0.0 1.8e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 VDK79814.1 - 0.042 14.1 0.0 0.093 12.9 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain mTERF PF02536.14 VDK79816.1 - 7.2e-13 48.1 0.3 2.9e-12 46.1 0.4 1.8 1 1 0 1 1 1 1 mTERF Tom22 PF04281.13 VDK79817.1 - 1.6e-12 47.4 0.1 2e-12 47.0 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 UPF0542 PF15086.6 VDK79817.1 - 0.043 13.7 0.1 0.057 13.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 TIP49 PF06068.13 VDK79818.1 - 1.5e-164 547.3 0.2 1.9e-164 547.0 0.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 VDK79818.1 - 1.4e-22 79.6 0.7 3.5e-22 78.3 0.1 2.1 2 0 0 2 2 1 1 TIP49 AAA-lid domain AAA PF00004.29 VDK79818.1 - 3.6e-12 46.9 0.1 1.5e-07 31.9 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 VDK79818.1 - 1.2e-10 41.4 0.1 8.9e-07 28.8 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK79818.1 - 3.6e-07 30.5 0.0 0.014 15.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 VDK79818.1 - 3.7e-05 24.2 0.0 0.00074 19.9 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 VDK79818.1 - 6.2e-05 23.0 0.1 0.012 15.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 VDK79818.1 - 0.00015 22.3 0.0 0.013 16.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 VDK79818.1 - 0.00042 20.0 0.0 0.00088 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 VDK79818.1 - 0.00049 19.8 0.0 0.79 9.4 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_19 PF13245.6 VDK79818.1 - 0.00058 20.2 0.2 0.36 11.1 0.1 2.7 3 0 0 3 3 2 1 AAA domain Mg_chelatase PF01078.21 VDK79818.1 - 0.00063 19.2 0.1 0.058 12.8 0.0 2.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 VDK79818.1 - 0.0029 17.9 0.0 0.0095 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 VDK79818.1 - 0.0046 16.7 0.1 0.0094 15.7 0.1 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DnaB_C PF03796.15 VDK79818.1 - 0.0097 15.3 0.0 0.025 13.9 0.0 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_14 PF13173.6 VDK79818.1 - 0.0098 15.9 0.0 5.3 7.1 0.0 3.1 4 0 0 4 4 4 1 AAA domain AAA_7 PF12775.7 VDK79818.1 - 0.011 15.2 0.1 0.047 13.2 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 VDK79818.1 - 0.019 14.4 0.1 0.056 12.9 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 VDK79818.1 - 0.025 13.9 0.1 0.05 12.9 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 VDK79818.1 - 0.027 14.3 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 VDK79818.1 - 0.028 14.6 0.0 0.094 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 VDK79818.1 - 0.042 13.9 0.1 1 9.3 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 VDK79818.1 - 0.05 14.0 0.0 0.14 12.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase TniB PF05621.11 VDK79818.1 - 0.053 12.9 0.0 4.2 6.7 0.0 2.9 3 0 0 3 3 3 0 Bacterial TniB protein AAA_30 PF13604.6 VDK79818.1 - 0.055 13.2 0.1 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 VDK79818.1 - 0.065 12.5 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_lid_2 PF17863.1 VDK79818.1 - 0.085 12.7 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA lid domain TipE PF16972.5 VDK79818.1 - 0.096 11.8 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE TsaE PF02367.17 VDK79818.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SBF PF01758.16 VDK79820.1 - 5.3e-28 98.0 15.6 5.3e-28 98.0 15.6 1.6 1 1 0 1 1 1 1 Sodium Bile acid symporter family Sedlin_N PF04628.13 VDK79822.1 - 9e-44 148.8 2.8 1e-43 148.6 2.8 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 VDK79822.1 - 4.3e-08 33.2 0.7 6.7e-08 32.6 0.7 1.4 1 1 0 1 1 1 1 Sybindin-like family Miff PF05644.11 VDK79823.1 - 4.4e-19 69.2 7.1 7e-14 52.1 1.1 2.0 1 1 1 2 2 2 2 Mitochondrial and peroxisomal fission factor Mff YabA PF06156.13 VDK79826.1 - 0.047 14.3 1.2 0.1 13.2 0.6 1.9 1 1 0 1 1 1 0 Initiation control protein YabA Actin PF00022.19 VDK79828.1 - 4e-127 424.2 0.0 4.5e-127 424.1 0.0 1.0 1 0 0 1 1 1 1 Actin UBA_4 PF14555.6 VDK79829.1 - 3.5e-08 33.1 0.0 8.9e-08 31.8 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 VDK79829.1 - 1.2e-06 28.6 0.0 3.7e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 UBX domain NHase_alpha PF02979.16 VDK79829.1 - 0.032 13.6 0.0 0.073 12.4 0.0 1.6 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain Thioredoxin_7 PF13899.6 VDK79829.1 - 0.11 12.7 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like DUF4569 PF15133.6 VDK79829.1 - 0.43 10.3 3.7 0.82 9.3 3.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Spore_coat_CotO PF14153.6 VDK79829.1 - 1.2 9.1 9.8 0.041 13.8 3.7 1.6 2 0 0 2 2 2 0 Spore coat protein CotO Hormone_recep PF00104.30 VDK79830.1 - 2.6e-15 56.6 2.3 2.9e-15 56.4 1.0 1.7 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 VDK79830.1 - 0.0054 17.2 3.4 0.0054 17.2 3.4 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Fer4_11 PF13247.6 VDK79830.1 - 0.68 10.1 3.5 1.4 9.1 3.5 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain tRNA-synt_1 PF00133.22 VDK79846.1 - 7.3e-146 486.9 0.0 1e-144 483.1 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 VDK79846.1 - 6.8e-25 87.8 0.2 1.5e-24 86.7 0.2 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 VDK79846.1 - 1.7e-16 60.0 1.2 6.3e-08 31.8 0.0 4.5 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 VDK79846.1 - 3.6e-06 26.6 0.0 5.9e-05 22.7 0.0 2.5 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 Glyco_transf_22 PF03901.17 VDK79846.1 - 1.8e-05 24.2 7.1 0.00076 18.8 7.1 2.2 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family DUF2203 PF09969.9 VDK79846.1 - 0.039 14.7 0.5 0.093 13.5 0.5 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) PWI PF01480.17 VDK79846.1 - 0.057 13.7 0.0 2.7 8.4 0.0 2.8 2 0 0 2 2 2 0 PWI domain tRNA-synt_2d PF01409.20 VDK79847.1 - 3.7e-50 170.7 3.1 1e-31 110.3 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 VDK79847.1 - 1e-18 67.5 0.0 4.6e-18 65.4 0.0 2.1 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain ASH PF15780.5 VDK79848.1 - 0.036 14.3 0.0 0.099 12.9 0.0 1.7 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Methyltransf_4 PF02390.17 VDK79848.1 - 0.077 12.5 0.1 0.4 10.1 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase RRM_1 PF00076.22 VDK79849.1 - 1e-83 275.1 2.8 4.3e-17 61.7 0.1 6.4 6 0 0 6 6 6 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 VDK79849.1 - 3.2e-11 43.1 0.8 0.00011 22.1 0.0 5.6 6 0 0 6 6 6 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 VDK79849.1 - 2.9e-07 30.5 0.7 0.88 9.7 0.0 6.1 6 1 0 6 6 6 2 RNA binding motif RRM_occluded PF16842.5 VDK79849.1 - 1.4e-06 28.1 0.0 0.02 14.7 0.0 4.3 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_7 PF16367.5 VDK79849.1 - 2.1e-05 24.5 0.0 1.3 9.2 0.0 4.9 5 0 0 5 5 5 2 RNA recognition motif Presenilin PF01080.17 VDK79849.1 - 6 5.5 6.2 0.3 9.8 0.9 1.4 2 0 0 2 2 2 0 Presenilin Myosin_head PF00063.21 VDK79851.1 - 1.6e-279 928.8 12.4 1e-251 837.0 7.1 3.9 4 0 0 4 4 4 2 Myosin head (motor domain) Myosin_tail_1 PF01576.19 VDK79851.1 - 1.3e-142 476.9 258.8 1.6e-142 476.6 258.8 1.1 1 0 0 1 1 1 1 Myosin tail Myosin_N PF02736.19 VDK79851.1 - 1.1e-13 50.8 1.2 2.7e-13 49.5 1.2 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain SHE3 PF17078.5 VDK79851.1 - 0.00091 19.0 10.5 0.00091 19.0 10.5 9.3 2 2 5 9 9 9 2 SWI5-dependent HO expression protein 3 CENP-F_leu_zip PF10473.9 VDK79851.1 - 0.0048 16.9 35.0 0.0048 16.9 35.0 11.6 2 1 9 11 11 11 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-CRD PF17979.1 VDK79855.1 - 0.054 13.6 6.4 0.11 12.6 6.4 1.5 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions zf-B_box PF00643.24 VDK79855.1 - 0.077 13.2 6.3 0.14 12.3 6.3 1.4 1 0 0 1 1 1 0 B-box zinc finger Cadherin_3 PF16184.5 VDK79865.1 - 2.7e-139 455.6 25.5 4.7e-16 58.8 0.0 15.4 15 0 0 15 15 15 15 Cadherin-like GramPos_pilinBB PF16569.5 VDK79865.1 - 0.048 14.5 0.3 5.4 7.9 0.0 3.0 2 0 0 2 2 2 0 Gram-positive pilin backbone subunit 2, Cna-B-like domain GSHPx PF00255.19 VDK79866.1 - 7.1e-39 131.7 0.2 9.5e-39 131.3 0.2 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 VDK79866.1 - 1.3e-09 38.0 0.0 6.4e-09 35.8 0.0 2.0 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK79866.1 - 1.6e-06 27.9 0.0 4.2e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Redoxin DUF4174 PF13778.6 VDK79866.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) ArgJ PF01960.18 VDK79868.1 - 0.077 11.7 0.0 0.093 11.4 0.0 1.1 1 0 0 1 1 1 0 ArgJ family BACON PF13004.7 VDK79868.1 - 0.09 12.8 0.1 0.34 10.9 0.1 2.0 2 0 0 2 2 2 0 Putative binding domain, N-terminal GSHPx PF00255.19 VDK79868.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione peroxidase HMG_box PF00505.19 VDK79870.1 - 6e-15 55.4 0.6 1.3e-14 54.3 0.6 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK79870.1 - 5.1e-10 39.8 0.6 9.7e-10 38.9 0.6 1.5 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 VDK79870.1 - 0.031 14.8 0.9 0.058 14.0 0.1 1.7 1 1 1 2 2 2 0 YABBY protein Sec7 PF01369.20 VDK79873.1 - 7.7e-70 234.3 0.0 4.7e-69 231.7 0.0 2.4 2 0 0 2 2 2 1 Sec7 domain DCB PF16213.5 VDK79873.1 - 2.1e-31 109.0 0.1 2.6e-30 105.4 0.0 2.8 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.10 VDK79873.1 - 4.7e-29 100.1 0.1 4.7e-29 100.1 0.1 5.7 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) Sec7_N PF12783.7 VDK79873.1 - 5.3e-29 101.2 22.0 5.8e-29 101.0 8.5 5.0 4 2 1 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal TYA PF01021.19 VDK79874.1 - 0.014 15.7 1.3 0.017 15.4 1.3 1.3 1 1 0 1 1 1 0 TYA transposon protein Ldl_recept_a PF00057.18 VDK79876.1 - 0.00096 19.3 5.0 0.0017 18.5 5.0 1.4 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A Mesd PF10185.9 VDK79876.1 - 0.11 12.5 0.6 0.16 11.9 0.6 1.2 1 0 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor PBP1_TM PF14812.6 VDK79876.1 - 0.19 12.1 2.3 0.34 11.3 2.3 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_L32e PF01655.18 VDK79884.1 - 1e-49 167.4 2.9 1.4e-49 167.0 2.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L32 GTP_EFTU PF00009.27 VDK79886.1 - 6.4e-64 215.1 0.1 9.4e-64 214.5 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 VDK79886.1 - 4.9e-35 119.9 0.3 1.3e-34 118.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 VDK79886.1 - 2.9e-22 78.5 0.0 7.5e-22 77.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 VDK79886.1 - 3.9e-14 52.5 0.0 9.4e-14 51.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 VDK79886.1 - 1.6e-11 44.4 0.1 5.3e-11 42.8 0.1 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 VDK79886.1 - 1.7e-05 24.9 0.1 3.7e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF4317 PF14199.6 VDK79886.1 - 0.088 12.0 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) Peptidase_A22B PF04258.13 VDK79889.1 - 4.3e-53 180.7 24.5 7.7e-53 179.9 24.5 1.3 1 0 0 1 1 1 1 Signal peptide peptidase Orf78 PF06024.12 VDK79889.1 - 0.15 12.4 1.9 6.7 7.1 0.1 3.5 3 0 0 3 3 3 0 Orf78 (ac78) Podoplanin PF05808.11 VDK79889.1 - 0.25 11.5 0.9 0.49 10.5 0.9 1.4 1 0 0 1 1 1 0 Podoplanin DUF3040 PF11239.8 VDK79889.1 - 0.68 10.2 2.5 13 6.2 2.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Sld5 PF05916.11 VDK79894.1 - 5.1e-18 65.5 0.0 7.9e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein DAP PF15228.6 VDK79896.1 - 5.4e-05 24.3 0.1 6.4e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Death-associated protein Bromodomain PF00439.25 VDK79899.1 - 1.2e-107 352.2 17.8 1.1e-19 70.2 0.3 6.8 7 0 0 7 7 7 6 Bromodomain BAH PF01426.18 VDK79899.1 - 2.3e-35 121.1 3.5 2.2e-19 69.5 0.3 3.0 3 0 0 3 3 3 2 BAH domain DUF4250 PF14056.6 VDK79899.1 - 0.13 12.2 0.9 0.95 9.5 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) N2227 PF07942.12 VDK79911.1 - 6.9e-96 320.6 0.0 1.1e-95 320.0 0.0 1.3 1 0 0 1 1 1 1 N2227-like protein Methyltransf_12 PF08242.12 VDK79911.1 - 0.0083 16.9 0.0 0.045 14.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK79911.1 - 0.043 13.6 0.1 0.49 10.2 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 VDK79911.1 - 0.11 13.2 0.0 0.38 11.4 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain L51_S25_CI-B8 PF05047.16 VDK79912.1 - 7.8e-05 22.5 0.4 0.00015 21.6 0.1 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Med10 PF09748.9 VDK79913.1 - 9.9e-35 119.1 1.6 1.7e-34 118.3 1.6 1.4 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex UPF0203 PF05254.12 VDK79913.1 - 4.4e-15 55.7 0.5 4.4e-15 55.7 0.5 2.3 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0203) MRP-L47 PF06984.13 VDK79915.1 - 1.5e-31 108.3 0.2 3.1e-31 107.3 0.2 1.5 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF896 PF05979.12 VDK79915.1 - 0.067 13.1 0.4 6.2 6.8 0.1 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) TPR_2 PF07719.17 VDK79917.1 - 0.1 12.8 0.2 0.66 10.2 0.1 2.3 2 1 1 3 3 3 0 Tetratricopeptide repeat 5_nucleotid PF05761.14 VDK79918.1 - 8.7e-114 380.9 20.2 1.4e-105 353.9 4.9 2.9 3 0 0 3 3 3 2 5' nucleotidase family DUF236 PF03057.14 VDK79919.1 - 3.1e-26 91.0 3.9 2.7e-13 49.6 0.4 2.2 2 0 0 2 2 2 2 DUF236 repeat Raftlin PF15250.6 VDK79919.1 - 1.1 7.9 10.3 1.2 7.8 10.3 1.1 1 0 0 1 1 1 0 Raftlin LAP1C PF05609.12 VDK79919.1 - 1.9 7.5 14.4 2.2 7.3 14.4 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 VDK79919.1 - 3.4 5.8 19.8 4.1 5.6 19.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 VDK79919.1 - 4.1 6.1 14.3 4.6 5.9 14.3 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 VDK79919.1 - 6 6.0 8.5 7.1 5.7 8.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5321 PF17254.2 VDK79919.1 - 9.7 5.6 19.4 32 3.9 19.4 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5321) Topoisom_bac PF01131.20 VDK79923.1 - 6e-107 358.2 0.0 1.6e-106 356.8 0.0 1.6 2 0 0 2 2 2 1 DNA topoisomerase Toprim PF01751.22 VDK79923.1 - 3e-15 56.3 0.0 5.8e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Toprim domain zinc_ribbon_4 PF13717.6 VDK79923.1 - 0.019 14.9 8.4 0.5 10.3 0.0 4.2 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_S27 PF01599.19 VDK79923.1 - 0.45 10.7 0.0 0.45 10.7 0.0 5.0 5 1 0 5 5 5 0 Ribosomal protein S27a ADK_lid PF05191.14 VDK79923.1 - 1.7 8.7 4.6 3.1 7.9 0.1 3.3 2 1 0 2 2 2 0 Adenylate kinase, active site lid zinc_ribbon_12 PF11331.8 VDK79923.1 - 2.1 8.2 8.4 4.2 7.3 2.3 3.3 2 1 0 2 2 2 0 Probable zinc-ribbon domain DUF3615 PF12274.8 VDK79923.1 - 9.4 6.8 8.6 0.62 10.6 1.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3615) PAS_3 PF08447.12 VDK79925.1 - 3.8e-06 27.1 0.5 8e-06 26.1 0.1 1.8 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 VDK79925.1 - 1.3e-05 25.2 0.0 2.9e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 VDK79925.1 - 0.0014 18.6 0.0 0.0042 17.1 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 VDK79925.1 - 0.033 14.4 0.0 0.095 13.0 0.0 1.7 1 0 0 1 1 1 0 PAS domain DUF3523 PF12037.8 VDK79927.1 - 2.4e-87 292.7 34.9 3.8e-87 292.0 34.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) AAA PF00004.29 VDK79927.1 - 7.6e-23 81.4 0.0 2.5e-22 79.7 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 VDK79927.1 - 4.6e-06 27.1 5.0 0.00052 20.4 0.0 3.8 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 VDK79927.1 - 0.00021 21.1 0.0 0.00055 19.7 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK79927.1 - 0.0023 18.2 3.7 0.24 11.6 0.0 3.1 2 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 VDK79927.1 - 0.0025 17.8 2.3 0.031 14.3 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 VDK79927.1 - 0.0032 16.9 0.3 0.023 14.1 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 VDK79927.1 - 0.0035 17.5 0.0 0.0035 17.5 0.0 2.8 2 1 0 2 2 1 1 AAA domain AAA_24 PF13479.6 VDK79927.1 - 0.011 15.5 1.7 0.012 15.3 0.1 2.0 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 VDK79927.1 - 0.016 15.6 0.0 0.044 14.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 VDK79927.1 - 0.02 14.6 1.6 0.04 13.7 0.0 2.3 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_18 PF13238.6 VDK79927.1 - 0.04 14.5 1.4 0.13 12.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 VDK79927.1 - 0.041 14.0 0.0 0.089 12.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_lid_3 PF17862.1 VDK79927.1 - 0.057 13.2 0.0 0.21 11.4 0.0 2.0 1 0 0 1 1 1 0 AAA+ lid domain TsaE PF02367.17 VDK79927.1 - 0.072 13.1 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 VDK79927.1 - 0.075 12.5 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 VDK79927.1 - 0.15 12.3 0.0 0.15 12.3 0.0 3.8 3 1 1 4 4 3 0 AAA domain Parvo_NS1 PF01057.17 VDK79927.1 - 0.18 10.9 0.0 0.18 10.9 0.0 2.5 2 1 1 3 3 3 0 Parvovirus non-structural protein NS1 Zot PF05707.12 VDK79927.1 - 0.23 11.1 0.0 0.23 11.1 0.0 3.3 3 1 0 4 4 4 0 Zonular occludens toxin (Zot) DUF2624 PF11116.8 VDK79927.1 - 1.1 10.2 5.4 0.28 12.1 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) AAA_11 PF13086.6 VDK79927.1 - 1.4 8.7 0.0 1.4 8.7 0.0 3.2 2 1 0 2 2 1 0 AAA domain DUF3216 PF11505.8 VDK79927.1 - 4.5 7.5 9.8 2.1 8.6 1.5 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3216) Integrin_beta PF00362.18 VDK79935.1 - 2.8e-106 354.7 0.0 4.6e-106 354.0 0.0 1.3 1 0 0 1 1 1 1 Integrin beta chain VWA domain Integrin_b_cyt PF08725.11 VDK79935.1 - 3.7e-20 71.3 1.7 4.4e-20 71.1 0.2 2.0 2 0 0 2 2 2 1 Integrin beta cytoplasmic domain Integrin_B_tail PF07965.12 VDK79935.1 - 1.8e-17 63.6 5.0 1.8e-17 63.6 5.0 4.4 5 1 1 6 6 6 1 Integrin beta tail domain PSI_integrin PF17205.3 VDK79935.1 - 8.5e-11 41.4 8.0 8.5e-11 41.4 8.0 3.9 3 1 0 3 3 3 1 Integrin plexin domain I-EGF_1 PF18372.1 VDK79935.1 - 2.1e-10 40.5 69.2 2.2e-05 24.4 10.2 5.7 5 0 0 5 5 5 4 Integrin beta epidermal growth factor like domain 1 EGF_2 PF07974.13 VDK79935.1 - 2.5e-07 30.9 90.6 4.1e-06 27.1 15.4 6.4 5 2 1 6 6 6 3 EGF-like domain SNF2_N PF00176.23 VDK79938.1 - 3.6e-68 229.8 1.5 7e-68 228.9 1.5 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK79938.1 - 3.2e-16 59.6 0.0 1.2e-15 57.8 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HSA PF07529.13 VDK79938.1 - 1.5e-13 50.9 13.3 7.9e-13 48.5 9.6 3.2 1 1 1 2 2 2 1 HSA ResIII PF04851.15 VDK79938.1 - 3.2e-07 30.5 0.3 4.5e-06 26.8 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2683 PF10884.8 VDK79938.1 - 0.17 12.2 2.1 0.47 10.7 2.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) NAD_binding_3 PF03447.16 VDK79938.1 - 2.3 8.9 11.7 0.46 11.2 0.2 4.0 4 0 0 4 4 4 0 Homoserine dehydrogenase, NAD binding domain zf-C2H2_4 PF13894.6 VDK79940.1 - 4.4e-07 30.2 11.5 0.0012 19.6 0.8 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 VDK79940.1 - 8.9e-06 26.0 2.6 0.0048 17.1 0.2 3.1 3 0 0 3 3 3 1 Aberrant zinc-finger zf-C2H2 PF00096.26 VDK79940.1 - 1.4e-05 25.3 12.4 0.039 14.4 1.0 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 VDK79940.1 - 0.00072 19.5 0.8 0.00072 19.5 0.8 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 VDK79940.1 - 0.0019 18.4 1.1 1.9 8.9 0.0 3.1 2 1 1 3 3 3 2 C2H2-type zinc ribbon zf-C2H2_3rep PF18868.1 VDK79940.1 - 0.022 15.4 1.0 0.94 10.2 0.0 2.7 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf_ZIC PF18366.1 VDK79940.1 - 0.026 14.6 1.0 3.3 7.9 0.0 2.8 3 0 0 3 3 3 0 Zic proteins zinc finger domain FOXP-CC PF16159.5 VDK79940.1 - 0.027 15.1 1.6 1.2 9.8 0.0 3.1 3 0 0 3 3 3 0 FOXP coiled-coil domain zf-C2HE PF16278.5 VDK79940.1 - 0.027 14.9 0.1 0.26 11.8 0.0 2.4 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF629 PF04780.12 VDK79940.1 - 0.056 12.0 3.8 0.94 7.9 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF629) zf-Di19 PF05605.12 VDK79940.1 - 0.1 12.9 2.2 1.1 9.6 0.0 3.1 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 VDK79940.1 - 0.25 11.9 11.8 0.27 11.7 0.8 3.1 3 0 0 3 3 2 0 Zinc-finger double domain zf-C2H2_2 PF12756.7 VDK79940.1 - 2.8 8.3 6.6 3.6 8.0 1.4 2.9 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) ERCC3_RAD25_C PF16203.5 VDK79941.1 - 5.3e-116 386.1 2.2 1.1e-115 385.1 2.2 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 VDK79941.1 - 4.7e-36 123.7 0.0 1e-35 122.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK79941.1 - 1.6e-17 64.1 0.0 7.1e-17 61.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 VDK79941.1 - 2.5e-12 47.1 0.2 7.2e-12 45.6 0.2 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 VDK79941.1 - 0.002 16.9 0.0 0.0031 16.3 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain UCH_1 PF13423.6 VDK79942.1 - 4.2e-31 108.7 9.3 6.9e-31 108.0 9.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MMR_HSR1 PF01926.23 VDK79942.1 - 9.6e-21 74.0 0.1 4e-20 72.0 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 VDK79942.1 - 6.5e-17 61.6 2.1 1.7e-16 60.2 2.1 1.7 1 1 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.18 VDK79942.1 - 7.2e-06 25.6 0.0 2.1e-05 24.1 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B UCH PF00443.29 VDK79942.1 - 0.001 18.7 0.2 0.0027 17.2 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ANAPC4_WD40 PF12894.7 VDK79942.1 - 0.021 15.1 0.0 0.44 10.9 0.0 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Dynamin_N PF00350.23 VDK79942.1 - 0.033 14.2 0.0 2.1 8.4 0.0 2.6 1 1 1 2 2 2 0 Dynamin family TIP120 PF08623.10 VDK79942.1 - 0.068 12.9 0.4 4.1 7.1 0.1 2.5 2 1 0 2 2 2 0 TATA-binding protein interacting (TIP20) Phos_pyr_kin PF08543.12 VDK79954.1 - 0.00076 18.9 0.0 0.00098 18.6 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Thioredoxin_6 PF13848.6 VDK79955.1 - 3.3e-47 160.8 0.0 2.9e-39 134.9 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 VDK79955.1 - 4e-22 78.1 0.0 8.5e-22 77.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 VDK79955.1 - 0.00021 21.5 0.1 0.0013 19.1 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like Calsequestrin PF01216.17 VDK79955.1 - 0.00043 19.4 0.0 0.00067 18.8 0.0 1.3 1 0 0 1 1 1 1 Calsequestrin HyaE PF07449.11 VDK79955.1 - 0.0028 17.6 0.0 0.014 15.3 0.0 2.0 1 1 1 2 2 2 1 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.21 VDK79955.1 - 0.0096 15.8 0.0 0.028 14.3 0.0 1.7 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 VDK79955.1 - 0.011 16.1 0.0 0.033 14.6 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like domain OST3_OST6 PF04756.13 VDK79955.1 - 0.06 12.7 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family IBR PF01485.21 VDK79957.1 - 7.2e-22 77.4 44.3 3.4e-15 56.0 4.6 4.6 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 VDK79957.1 - 0.0014 18.5 12.2 0.0014 18.5 12.2 5.0 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK79957.1 - 0.0026 17.6 6.3 0.0026 17.6 6.3 5.6 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) FTCD_C PF04961.12 VDK79957.1 - 0.19 11.5 0.1 0.96 9.2 0.0 2.0 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase UPF0547 PF10571.9 VDK79957.1 - 2.6 8.2 12.4 4.3 7.5 0.1 4.2 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 ATP_bind_1 PF03029.17 VDK79959.1 - 2.8e-59 200.8 0.1 3.2e-59 200.6 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CDT1 PF08839.11 VDK79961.1 - 1.4e-28 100.4 5.9 1.8e-27 96.7 0.4 3.9 3 1 0 3 3 3 1 DNA replication factor CDT1 like CDT1_C PF16679.5 VDK79961.1 - 5.4e-16 58.8 0.5 9e-15 54.9 0.2 2.7 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain Sema PF01403.19 VDK79969.1 - 1.7e-50 172.1 0.1 2.4e-50 171.6 0.1 1.2 1 0 0 1 1 1 1 Sema domain TIG_2 PF18020.1 VDK79969.1 - 2.6e-21 76.0 0.0 1.3e-20 73.7 0.0 2.2 2 0 0 2 2 2 1 TIG domain found in plexin TIG_plexin PF17960.1 VDK79969.1 - 3e-21 75.2 0.0 3.8e-18 65.3 0.0 2.7 2 0 0 2 2 2 2 TIG domain PSI PF01437.25 VDK79969.1 - 2.7e-14 53.4 62.6 1.5e-08 35.1 11.5 4.5 6 0 0 6 6 6 3 Plexin repeat Zip PF02535.22 VDK79971.1 - 5.7e-54 183.6 12.3 6.8e-54 183.3 12.3 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2721 PF11026.8 VDK79971.1 - 0.007 16.2 0.8 0.007 16.2 0.8 3.1 4 0 0 4 4 4 2 Protein of unknown function (DUF2721) DUF4203 PF13886.6 VDK79971.1 - 0.3 10.7 21.1 0.26 10.9 8.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4203) BTB PF00651.31 VDK79973.1 - 0.0024 18.1 0.0 0.0061 16.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Endonuclease_7 PF02945.15 VDK79973.1 - 0.47 10.4 4.2 1.3 9.0 4.2 1.7 1 0 0 1 1 1 0 Recombination endonuclease VII Tnp_zf-ribbon_2 PF13842.6 VDK79973.1 - 8.6 7.3 11.6 1.6 9.6 4.3 2.9 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon PET PF06297.14 VDK79975.1 - 3.6e-30 104.1 3.5 3.9e-30 104.0 0.0 2.8 2 1 1 3 3 3 1 PET Domain LIM PF00412.22 VDK79975.1 - 2.4e-24 85.3 53.7 3.4e-11 43.2 6.7 5.4 6 0 0 6 6 6 3 LIM domain Chordopox_RPO7 PF05864.12 VDK79975.1 - 0.56 10.5 5.9 17 5.8 1.2 3.7 3 0 0 3 3 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) APS_kinase PF01583.20 VDK79977.1 - 8.3e-70 233.7 0.0 1.3e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.17 VDK79977.1 - 5.2e-66 222.1 0.0 7.5e-66 221.6 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 VDK79977.1 - 4.4e-39 133.7 0.0 8.9e-39 132.7 0.0 1.5 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 VDK79977.1 - 1.8e-06 28.2 0.0 3.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain CTP_transf_like PF01467.26 VDK79977.1 - 0.0073 16.5 0.1 3.7 7.7 0.0 2.5 2 0 0 2 2 2 2 Cytidylyltransferase-like AAA_18 PF13238.6 VDK79977.1 - 0.013 16.0 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 VDK79977.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 VDK79977.1 - 0.072 13.5 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 VDK79977.1 - 0.13 12.7 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain TTR-52 PF01060.23 VDK79978.1 - 2.2e-09 37.9 0.0 3e-07 31.0 0.0 2.3 1 1 0 1 1 1 1 Transthyretin-like family Sema PF01403.19 VDK79984.1 - 1.7e-50 172.1 0.1 2.4e-50 171.6 0.1 1.2 1 0 0 1 1 1 1 Sema domain TIG_2 PF18020.1 VDK79984.1 - 2.6e-21 76.0 0.0 1.3e-20 73.7 0.0 2.2 2 0 0 2 2 2 1 TIG domain found in plexin TIG_plexin PF17960.1 VDK79984.1 - 3e-21 75.2 0.0 3.8e-18 65.3 0.0 2.7 2 0 0 2 2 2 2 TIG domain PSI PF01437.25 VDK79984.1 - 2.7e-14 53.4 62.6 1.5e-08 35.1 11.5 4.5 6 0 0 6 6 6 3 Plexin repeat Zip PF02535.22 VDK79987.1 - 5.7e-54 183.6 12.3 6.8e-54 183.3 12.3 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2721 PF11026.8 VDK79987.1 - 0.007 16.2 0.8 0.007 16.2 0.8 3.1 4 0 0 4 4 4 2 Protein of unknown function (DUF2721) DUF4203 PF13886.6 VDK79987.1 - 0.3 10.7 21.1 0.26 10.9 8.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4203) BTB PF00651.31 VDK79988.1 - 0.0024 18.1 0.0 0.0061 16.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Endonuclease_7 PF02945.15 VDK79988.1 - 0.47 10.4 4.2 1.3 9.0 4.2 1.7 1 0 0 1 1 1 0 Recombination endonuclease VII Tnp_zf-ribbon_2 PF13842.6 VDK79988.1 - 8.6 7.3 11.6 1.6 9.6 4.3 2.9 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon PET PF06297.14 VDK79990.1 - 3.6e-30 104.1 3.5 3.9e-30 104.0 0.0 2.8 2 1 1 3 3 3 1 PET Domain LIM PF00412.22 VDK79990.1 - 2.4e-24 85.3 53.7 3.4e-11 43.2 6.7 5.4 6 0 0 6 6 6 3 LIM domain Chordopox_RPO7 PF05864.12 VDK79990.1 - 0.56 10.5 5.9 17 5.8 1.2 3.7 3 0 0 3 3 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) APS_kinase PF01583.20 VDK79991.1 - 8.3e-70 233.7 0.0 1.3e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase ATP-sulfurylase PF01747.17 VDK79991.1 - 5.2e-66 222.1 0.0 7.5e-66 221.6 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 VDK79991.1 - 4.4e-39 133.7 0.0 8.9e-39 132.7 0.0 1.5 1 0 0 1 1 1 1 PUA-like domain AAA_33 PF13671.6 VDK79991.1 - 1.8e-06 28.2 0.0 3.6e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain CTP_transf_like PF01467.26 VDK79991.1 - 0.0073 16.5 0.1 3.7 7.7 0.0 2.5 2 0 0 2 2 2 2 Cytidylyltransferase-like AAA_18 PF13238.6 VDK79991.1 - 0.013 16.0 0.0 0.034 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 VDK79991.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 VDK79991.1 - 0.072 13.5 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 VDK79991.1 - 0.13 12.7 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain TTR-52 PF01060.23 VDK79992.1 - 2.2e-09 37.9 0.0 3e-07 31.0 0.0 2.3 1 1 0 1 1 1 1 Transthyretin-like family DUF4136 PF13590.6 VDK80011.1 - 0.015 15.9 0.3 0.022 15.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4136) FNIP_N PF14636.6 VDK80011.1 - 6.7 7.7 16.6 4.5 8.2 8.2 2.2 1 1 1 2 2 2 0 Folliculin-interacting protein N-terminus RGS PF00615.19 VDK80012.1 - 1.3e-23 83.5 0.2 3.2e-23 82.2 0.2 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain RBD PF02196.15 VDK80012.1 - 0.0035 17.4 0.0 0.013 15.5 0.0 1.9 2 0 0 2 2 2 1 Raf-like Ras-binding domain RRM_1 PF00076.22 VDK80013.1 - 3.4e-05 23.6 0.0 6.6e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 VDK80013.1 - 0.00041 20.8 4.2 0.00041 20.8 4.2 2.4 3 0 0 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 Ribosomal_L18 PF17135.4 VDK80014.1 - 1.2e-88 295.4 2.9 1.4e-88 295.2 2.9 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 VDK80014.1 - 0.041 14.6 0.2 0.095 13.4 0.2 1.7 1 1 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A LapA_dom PF06305.11 VDK80017.1 - 0.12 12.1 0.1 0.3 10.9 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Kinesin PF00225.23 VDK80019.1 - 1.9e-117 392.0 1.7 1.9e-117 392.0 1.7 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 VDK80019.1 - 5.7e-30 104.2 0.8 2.8e-29 102.0 0.2 2.4 2 0 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 VDK80019.1 - 0.16 12.1 12.4 0.46 10.6 10.0 2.6 2 1 0 2 2 2 0 Kinesin-associated PI31_Prot_N PF11566.8 VDK80019.1 - 0.27 11.0 5.5 0.085 12.7 1.2 2.4 3 0 0 3 3 3 0 PI31 proteasome regulator N-terminal DUF4407 PF14362.6 VDK80019.1 - 2.2 7.5 21.8 6.5 6.0 21.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF573 PF04504.14 VDK80019.1 - 5.3 7.8 11.7 0.43 11.3 3.7 3.2 3 1 0 4 4 4 0 Protein of unknown function, DUF573 Fib_alpha PF08702.10 VDK80019.1 - 6.8 6.9 24.5 0.038 14.2 4.9 3.4 2 1 3 5 5 5 0 Fibrinogen alpha/beta chain family PP2C PF00481.21 VDK80041.1 - 0.0077 15.9 0.1 0.02 14.5 0.1 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C LBP_BPI_CETP_C PF02886.17 VDK80042.1 - 1.8e-21 76.7 0.4 2.1e-21 76.5 0.4 1.1 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP_C PF02886.17 VDK80044.1 - 1.1e-27 97.0 0.0 2.4e-27 95.9 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 VDK80044.1 - 2e-22 79.6 0.0 4.5e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain KH_1 PF00013.29 VDK80045.1 - 6e-18 64.4 2.4 4.2e-14 52.1 0.3 4.4 4 0 0 4 4 4 2 KH domain SAM_1 PF00536.30 VDK80045.1 - 2.7e-14 53.3 0.1 6.4e-14 52.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK80045.1 - 4.3e-09 36.3 0.1 1.1e-08 35.1 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) KH_10 PF17905.1 VDK80045.1 - 0.00037 20.9 4.3 0.039 14.4 0.2 4.3 4 1 0 4 4 4 1 GLD-3 KH domain 5 CPG4 PF15481.6 VDK80049.1 - 0.046 14.3 10.1 0.2 12.3 10.1 2.1 1 1 0 1 1 1 0 Chondroitin proteoglycan 4 NDUFA12 PF05071.16 VDK80050.1 - 4.4e-26 91.5 6.9 8.1e-26 90.7 6.9 1.5 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 SEP PF08059.13 VDK80050.1 - 1.9e-20 73.2 0.0 1e-19 70.8 0.0 2.2 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 VDK80050.1 - 7.2e-15 55.0 0.0 1.5e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 UBX domain UPF0242 PF06785.11 VDK80051.1 - 9.4e-05 22.6 4.5 0.00012 22.2 4.5 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Prominin PF05478.11 VDK80051.1 - 0.0061 14.6 1.5 0.0068 14.4 1.5 1.1 1 0 0 1 1 1 1 Prominin ExsD PF16806.5 VDK80051.1 - 0.036 14.0 0.7 0.052 13.5 0.7 1.2 1 0 0 1 1 1 0 Antiactivator protein ExsD PSII_Pbs27 PF13326.6 VDK80051.1 - 0.054 13.8 0.6 0.38 11.1 0.6 2.2 1 1 0 1 1 1 0 Photosystem II Pbs27 DUF948 PF06103.11 VDK80051.1 - 0.074 13.3 3.4 4.1 7.7 0.4 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4972 PF16342.5 VDK80051.1 - 0.081 12.6 3.0 0.21 11.3 1.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4972) STAT_alpha PF01017.20 VDK80051.1 - 0.11 12.4 7.5 0.18 11.7 7.5 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain Syntaxin_2 PF14523.6 VDK80051.1 - 0.2 12.1 6.3 0.079 13.3 3.6 1.8 2 0 0 2 2 2 0 Syntaxin-like protein K_trans PF02705.16 VDK80051.1 - 0.31 9.5 1.1 0.39 9.2 1.1 1.1 1 0 0 1 1 1 0 K+ potassium transporter RlaP PF10127.9 VDK80051.1 - 0.33 10.5 5.6 0.41 10.2 5.6 1.1 1 0 0 1 1 1 0 RNA repair pathway DNA polymerase beta family I_LWEQ PF01608.17 VDK80051.1 - 0.62 10.3 6.9 1 9.6 6.9 1.3 1 0 0 1 1 1 0 I/LWEQ domain FliD_N PF02465.18 VDK80051.1 - 1.3 9.8 4.2 0.65 10.7 1.4 1.9 2 1 1 3 3 2 0 Flagellar hook-associated protein 2 N-terminus HIP1_clath_bdg PF16515.5 VDK80051.1 - 1.4 9.6 12.6 0.59 10.8 8.1 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF745 PF05335.13 VDK80051.1 - 1.5 8.5 4.5 2.1 8.1 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF1664 PF07889.12 VDK80051.1 - 7.9 6.5 8.4 3.1 7.9 1.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Laminin_G_2 PF02210.24 VDK80053.1 - 2.9e-32 111.9 6.7 1.6e-16 61.0 0.1 5.7 5 1 0 5 5 5 3 Laminin G domain Laminin_G_1 PF00054.23 VDK80053.1 - 1.6e-25 89.8 0.9 3.9e-13 49.8 0.0 5.2 5 1 1 6 6 6 3 Laminin G domain Laminin_G_3 PF13385.6 VDK80053.1 - 6.2e-06 26.4 7.2 0.00034 20.8 0.0 3.9 5 0 0 5 5 5 2 Concanavalin A-like lectin/glucanases superfamily EGF PF00008.27 VDK80053.1 - 3.2e-05 24.1 33.4 0.002 18.4 6.3 3.6 3 0 0 3 3 3 2 EGF-like domain Peptidase_S15 PF02129.18 VDK80066.1 - 0.11 12.0 0.4 0.2 11.2 0.4 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) PHD PF00628.29 VDK80067.1 - 0.0039 17.1 12.7 0.02 14.8 12.7 2.2 1 1 0 1 1 1 1 PHD-finger Pkinase_Tyr PF07714.17 VDK80072.1 - 5.8e-88 294.5 0.0 9.5e-88 293.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK80072.1 - 6.8e-37 127.3 0.3 1e-25 90.6 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Ig_3 PF13927.6 VDK80072.1 - 3.2e-25 88.5 0.0 0.00035 21.1 0.0 5.9 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 VDK80072.1 - 4e-24 84.5 0.2 1.3e-05 25.2 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin I-set domain ig PF00047.25 VDK80072.1 - 7.8e-19 67.6 0.3 1.8e-06 28.0 0.0 5.5 5 0 0 5 5 5 3 Immunoglobulin domain Ig_2 PF13895.6 VDK80072.1 - 2.4e-15 56.6 0.5 3.3e-05 24.1 0.0 5.2 5 0 0 5 5 5 3 Immunoglobulin domain V-set PF07686.17 VDK80072.1 - 6.2e-13 48.9 3.8 0.14 12.3 0.0 6.8 6 3 0 6 6 6 4 Immunoglobulin V-set domain LapA_dom PF06305.11 VDK80072.1 - 0.00057 19.6 0.5 0.0012 18.6 0.5 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Ig_6 PF18452.1 VDK80072.1 - 0.0013 18.2 0.0 1.2 8.7 0.0 3.3 3 0 0 3 3 3 1 Immunoglobulin domain Ig_5 PF16681.5 VDK80072.1 - 0.011 16.1 3.5 17 5.9 0.0 4.9 6 0 0 6 6 4 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 VDK80072.1 - 0.097 13.0 0.0 33 4.8 0.0 3.3 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain DUF4381 PF14316.6 VDK80072.1 - 0.2 11.9 0.2 0.38 11.0 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF2206 PF09971.9 VDK80077.1 - 0.097 11.4 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) GET2 PF08690.10 VDK80077.1 - 0.12 12.1 0.1 0.12 12.1 0.1 1.7 2 0 0 2 2 2 0 GET complex subunit GET2 SNARE PF05739.19 VDK80077.1 - 1.3 9.0 6.9 0.36 10.9 3.3 1.9 2 0 0 2 2 2 0 SNARE domain Rpr2 PF04032.16 VDK80079.1 - 0.21 11.9 3.1 0.61 10.4 2.1 2.4 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain CPG4 PF15481.6 VDK80080.1 - 2.4e-24 85.8 6.1 6e-24 84.5 6.1 1.7 1 0 0 1 1 1 1 Chondroitin proteoglycan 4 RhoGAP PF00620.27 VDK80080.1 - 0.12 12.2 0.1 0.6 9.9 0.0 1.9 2 0 0 2 2 2 0 RhoGAP domain Pkinase PF00069.25 VDK80082.1 - 8.7e-66 222.0 0.0 2.4e-65 220.6 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80082.1 - 3.4e-32 111.7 0.0 8.2e-32 110.5 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK80082.1 - 0.032 13.6 1.0 0.15 11.4 0.1 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Vinculin PF01044.19 VDK80104.1 - 0 1471.9 8.4 0 1471.7 8.4 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 VDK80104.1 - 0.0017 18.6 24.2 0.19 12.0 0.1 6.2 5 2 1 6 6 6 3 I/LWEQ domain Clusterin PF01093.17 VDK80104.1 - 0.0064 15.6 0.1 0.016 14.3 0.1 1.6 1 0 0 1 1 1 1 Clusterin Abi_C PF14355.6 VDK80104.1 - 0.027 14.6 0.2 1.7 8.8 0.0 4.1 4 1 1 5 5 5 0 Abortive infection C-terminus DUF3140 PF11338.8 VDK80104.1 - 0.17 12.3 4.6 12 6.4 0.1 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3140) DUF883 PF05957.13 VDK80104.1 - 1.2 9.7 8.0 2.8 8.6 0.1 4.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) PGM_PMM_I PF02878.16 VDK80106.1 - 1.7e-18 66.6 0.1 2.3e-09 37.1 0.1 2.7 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 VDK80106.1 - 2.5e-09 37.2 0.0 6.7e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 VDK80106.1 - 5.4e-05 23.4 0.0 0.00011 22.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 VDK80106.1 - 0.01 16.5 0.1 0.067 13.8 0.0 2.3 2 1 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Ras PF00071.22 VDK80107.1 - 1.3e-54 184.2 0.2 4.5e-54 182.4 0.1 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 VDK80107.1 - 2.8e-22 79.2 0.0 1.4e-21 76.9 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK80107.1 - 3.6e-08 33.1 0.1 1e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family PUF PF00806.19 VDK80107.1 - 9.9e-07 28.1 0.5 1.7 8.5 0.0 6.0 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat GTP_EFTU PF00009.27 VDK80107.1 - 5.4e-06 26.1 0.3 2.7e-05 23.8 0.1 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK80107.1 - 4.6e-05 23.4 0.0 0.09 12.7 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 VDK80107.1 - 0.00022 21.3 0.0 0.00058 19.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK80107.1 - 0.032 13.7 0.1 0.11 12.1 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B S-methyl_trans PF02574.16 VDK80107.1 - 0.052 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Homocysteine S-methyltransferase PHD PF00628.29 VDK80109.1 - 9.4e-10 38.2 9.9 4.4e-09 36.1 9.9 2.3 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 VDK80109.1 - 0.0013 19.1 0.0 0.0013 19.1 0.0 2.8 2 1 0 2 2 2 1 SET domain PHD_2 PF13831.6 VDK80109.1 - 1.7 8.2 6.3 0.87 9.2 3.0 2.2 2 0 0 2 2 2 0 PHD-finger RRM_1 PF00076.22 VDK80118.1 - 8.2e-13 48.0 0.1 6.1e-07 29.2 0.0 3.4 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK80119.1 - 0.005 16.7 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_1 PF00076.22 VDK80119.1 - 0.012 15.4 0.0 0.032 14.0 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4523 PF15023.6 VDK80119.1 - 0.014 15.2 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Deltaretro_Tax PF05599.11 VDK80120.1 - 0.018 15.5 0.2 0.19 12.3 0.2 2.1 2 0 0 2 2 2 0 Deltaretrovirus Tax protein Mt_ATP-synt_D PF05873.12 VDK80121.1 - 2.1e-24 86.1 7.1 2.1e-24 86.1 7.1 1.4 2 0 0 2 2 2 1 ATP synthase D chain, mitochondrial (ATP5H) FH2 PF02181.23 VDK80121.1 - 0.00084 18.6 1.4 0.0013 17.9 1.4 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain NPV_P10 PF05531.12 VDK80121.1 - 0.031 14.7 1.3 1.7 9.1 0.1 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4852 PF16144.5 VDK80121.1 - 0.072 13.2 3.0 0.3 11.2 2.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4852) DUF2730 PF10805.8 VDK80121.1 - 0.12 12.4 0.8 0.46 10.6 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DegS PF05384.11 VDK80121.1 - 0.13 11.7 1.2 0.22 11.0 1.2 1.4 1 0 0 1 1 1 0 Sensor protein DegS Prefoldin PF02996.17 VDK80121.1 - 0.18 11.8 1.4 8.9 6.3 0.0 2.5 2 0 0 2 2 2 0 Prefoldin subunit YolD PF08863.10 VDK80121.1 - 0.28 11.3 4.7 3.3 7.8 0.3 3.3 2 1 0 3 3 3 0 YolD-like protein TMPIT PF07851.13 VDK80121.1 - 0.34 10.1 2.3 0.48 9.6 2.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein PCI PF01399.27 VDK80122.1 - 1.2e-09 38.6 1.5 1.1e-08 35.5 0.1 2.4 2 1 0 2 2 2 1 PCI domain Geminin PF07412.12 VDK80122.1 - 0.003 17.3 0.0 0.006 16.4 0.0 1.4 1 0 0 1 1 1 1 Geminin zf-CCCH PF00642.24 VDK80124.1 - 1.4e-08 34.4 1.0 2.2e-08 33.8 1.0 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 VDK80124.1 - 0.002 17.9 1.3 0.0032 17.2 1.3 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 VDK80124.1 - 0.0024 17.9 0.9 0.0061 16.6 0.9 1.7 1 1 0 1 1 1 1 Zinc finger domain DUF1713 PF08213.11 VDK80125.1 - 1 9.4 23.7 0.29 11.1 20.3 1.9 1 1 1 2 2 2 0 Mitochondrial domain of unknown function (DUF1713) Fungal_TACC PF12709.7 VDK80125.1 - 7.1 7.1 12.2 0.51 10.8 1.1 2.5 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Collagen PF01391.18 VDK80126.1 - 3.5e-13 49.1 67.3 15 5.4 63.6 3.2 2 1 0 2 2 2 1 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK80127.1 - 4.2e-11 42.7 0.6 5.6e-11 42.3 0.6 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Collagen PF01391.18 VDK80127.1 - 2.8e-07 30.2 24.7 4.2e-05 23.2 14.0 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) Sulfate_transp PF00916.20 VDK80127.1 - 0.05 12.4 0.3 0.06 12.1 0.3 1.1 1 0 0 1 1 1 0 Sulfate permease family Pox_LP_H2 PF03356.15 VDK80127.1 - 0.15 11.9 0.2 0.18 11.6 0.2 1.1 1 0 0 1 1 1 0 Viral late protein H2 Hint PF01079.20 VDK80128.1 - 1.6e-39 135.7 0.0 3.2e-39 134.7 0.0 1.4 1 0 0 1 1 1 1 Hint module Hce2 PF14856.6 VDK80128.1 - 0.022 15.1 0.4 0.21 11.9 0.0 2.6 2 0 0 2 2 2 0 Pathogen effector; putative necrosis-inducing factor Hint_2 PF13403.6 VDK80128.1 - 0.086 13.1 0.0 0.22 11.8 0.0 1.7 2 0 0 2 2 2 0 Hint domain zf-RING_2 PF13639.6 VDK80140.1 - 1.1e-12 48.1 8.0 1.1e-12 48.1 8.0 2.6 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK80140.1 - 1.2e-08 34.6 7.2 4e-08 32.9 7.2 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK80140.1 - 3.6e-08 33.6 3.3 3.6e-08 33.6 3.3 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 VDK80140.1 - 5.7e-08 32.4 1.9 1.4e-07 31.1 1.9 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 VDK80140.1 - 1.8e-06 27.7 5.7 1.8e-06 27.7 5.7 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK80140.1 - 3.7e-06 26.8 3.8 3.7e-06 26.8 3.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 VDK80140.1 - 9e-05 22.5 1.8 9e-05 22.5 1.8 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 VDK80140.1 - 9.7e-05 22.2 3.4 9.7e-05 22.2 3.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK80140.1 - 0.00018 21.5 6.6 0.00018 21.5 6.6 2.4 2 0 0 2 2 2 1 RING-type zinc-finger PspB PF06667.12 VDK80140.1 - 0.0077 16.3 0.5 0.016 15.2 0.5 1.5 1 0 0 1 1 1 1 Phage shock protein B PEN-2 PF10251.9 VDK80140.1 - 0.015 15.7 0.2 0.028 14.8 0.2 1.3 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase CrgA PF06781.12 VDK80140.1 - 0.075 13.1 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Cell division protein CrgA Zn_ribbon_17 PF17120.5 VDK80140.1 - 0.13 11.9 7.6 0.024 14.3 2.7 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type NADH_4Fe-4S PF10589.9 VDK80140.1 - 0.14 12.3 0.2 0.46 10.6 0.1 1.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region Prok-RING_4 PF14447.6 VDK80140.1 - 0.24 11.3 15.6 0.036 13.9 9.7 2.6 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 F-box PF00646.33 VDK80142.1 - 0.0002 21.1 1.1 0.0033 17.3 0.1 2.9 2 0 0 2 2 2 1 F-box domain PRANC PF09372.10 VDK80142.1 - 0.0058 16.9 2.8 0.037 14.3 0.0 3.0 3 1 0 3 3 3 1 PRANC domain F-box-like PF12937.7 VDK80142.1 - 0.0082 16.0 0.0 0.026 14.4 0.0 1.9 1 0 0 1 1 1 1 F-box-like SCP-1 PF05483.12 VDK80142.1 - 0.012 13.7 0.7 0.016 13.3 0.7 1.1 1 0 0 1 1 1 0 Synaptonemal complex protein 1 (SCP-1) DUF677 PF05055.12 VDK80142.1 - 0.043 12.7 0.5 0.079 11.8 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF677) F-box_4 PF15966.5 VDK80142.1 - 0.05 13.5 0.1 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 F-box DUF4164 PF13747.6 VDK80142.1 - 0.062 13.6 0.8 2.5 8.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) CHD5 PF04420.14 VDK80142.1 - 0.13 12.2 0.5 0.22 11.4 0.1 1.6 2 0 0 2 2 2 0 CHD5-like protein Flu_B_NS1 PF02942.14 VDK80142.1 - 0.26 10.3 1.7 0.34 9.9 0.4 1.7 2 0 0 2 2 2 0 Influenza B non-structural protein (NS1) YkyA PF10368.9 VDK80142.1 - 1.3 8.7 5.8 13 5.4 0.1 2.2 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein GLTP PF08718.11 VDK80143.1 - 2.1e-39 135.2 0.1 2.5e-39 134.9 0.1 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Cu_amine_oxidN2 PF02727.16 VDK80143.1 - 0.025 14.8 0.0 0.042 14.1 0.0 1.3 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain HOIP-UBA PF16678.5 VDK80143.1 - 0.03 14.3 0.0 0.054 13.5 0.0 1.3 1 1 0 1 1 1 0 HOIP UBA domain pair HTH_5 PF01022.20 VDK80143.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Vps54 PF07928.12 VDK80143.1 - 0.17 12.4 0.7 1.3 9.4 0.2 2.2 1 1 1 2 2 2 0 Vps54-like protein ATP-synt_C PF00137.21 VDK80145.1 - 4.3e-09 36.6 11.0 6.6e-09 36.0 11.0 1.3 1 0 0 1 1 1 1 ATP synthase subunit C AMP-binding PF00501.28 VDK80147.1 - 1.4e-07 30.5 0.0 1.1e-06 27.5 0.0 1.9 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding PF00501.28 VDK80148.1 - 2.6e-88 296.5 0.0 3.2e-88 296.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 VDK80148.1 - 2.1e-21 76.7 2.3 2.8e-21 76.3 0.5 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 VDK80148.1 - 8e-05 22.5 1.6 0.00013 21.8 0.0 2.0 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus DMRL_synthase PF00885.19 VDK80148.1 - 0.026 14.4 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 6,7-dimethyl-8-ribityllumazine synthase zf-C3HC4 PF00097.25 VDK80150.1 - 3.5e-07 30.0 15.4 3.5e-07 30.0 15.4 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK80150.1 - 3.1e-05 23.7 15.1 3.1e-05 23.7 15.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK80150.1 - 6.9e-05 22.6 15.5 6.9e-05 22.6 15.5 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK80150.1 - 0.00012 22.0 7.8 0.00012 22.0 7.8 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 VDK80150.1 - 0.00023 21.1 15.0 0.00023 21.1 15.0 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 VDK80150.1 - 0.00039 20.7 15.3 0.00039 20.7 15.3 1.9 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 VDK80150.1 - 0.0011 18.7 12.8 0.0011 18.7 12.8 2.2 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 VDK80150.1 - 0.0036 17.1 10.0 0.0036 17.1 10.0 2.6 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 VDK80150.1 - 0.0042 16.9 13.5 0.0076 16.1 13.5 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 VDK80150.1 - 0.0062 16.7 14.5 0.0062 16.7 14.5 1.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING PDEase_I PF00233.19 VDK80150.1 - 0.088 12.5 0.1 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase BRCT_2 PF16589.5 VDK80153.1 - 1.2e-09 38.4 0.2 2.2e-05 24.7 0.0 2.5 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 VDK80153.1 - 2.2e-05 24.7 0.7 0.13 12.6 0.1 2.8 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 VDK80153.1 - 0.00032 20.5 0.1 0.048 13.5 0.0 2.7 2 0 0 2 2 2 2 Regulator of Ty1 transposition protein 107 BRCT domain RNA_pol_L_2 PF13656.6 VDK80153.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain TGF_beta PF00019.20 VDK80154.1 - 1.5e-22 80.5 3.2 2.8e-22 79.7 3.2 1.5 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 VDK80154.1 - 7.9e-05 22.5 0.4 0.0029 17.4 0.4 2.1 1 1 0 1 1 1 1 TGF-beta propeptide Foie-gras_1 PF11817.8 VDK80156.1 - 4.5e-28 98.6 0.0 7.1e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Foie gras liver health family 1 Gryzun-like PF12742.7 VDK80156.1 - 8.3e-05 22.5 0.2 0.00058 19.8 0.1 2.5 2 0 0 2 2 2 1 Gryzun, putative Golgi trafficking Gryzun PF07919.12 VDK80156.1 - 0.03 13.1 0.0 0.049 12.4 0.0 1.2 1 0 0 1 1 1 0 Gryzun, putative trafficking through Golgi DUF3992 PF13157.6 VDK80156.1 - 0.081 13.7 0.2 0.4 11.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3992) DUF35_N PF12172.8 VDK80156.1 - 0.16 11.9 0.1 0.32 10.9 0.1 1.6 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Cu_bind_CorA PF18252.1 VDK80156.1 - 0.17 11.5 0.0 0.48 10.0 0.0 1.7 1 0 0 1 1 1 0 Copper(I)-binding protein CorA adh_short PF00106.25 VDK80180.1 - 6.8e-47 159.5 0.9 8.5e-47 159.1 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK80180.1 - 2.1e-34 119.1 0.1 2.8e-34 118.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK80180.1 - 2.6e-14 53.5 0.6 4.2e-14 52.9 0.6 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 VDK80180.1 - 9.5e-05 21.5 1.6 0.00015 20.9 1.6 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 VDK80180.1 - 0.00058 19.1 0.6 0.00067 18.9 0.6 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein AlaDh_PNT_C PF01262.21 VDK80180.1 - 0.0018 17.6 0.6 0.0034 16.7 0.6 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain G3P_antiterm PF04309.12 VDK80180.1 - 0.023 14.1 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator 3HCDH_N PF02737.18 VDK80180.1 - 0.093 12.6 0.2 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Kelch_4 PF13418.6 VDK80180.1 - 0.16 12.0 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain RNA_pol_L_2 PF13656.6 VDK80182.1 - 1e-22 79.6 0.0 1.5e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 VDK80182.1 - 2.3e-08 33.4 0.0 3.3e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Tubulin PF00091.25 VDK80183.1 - 7.2e-63 212.4 0.0 1e-62 211.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK80183.1 - 3.9e-27 94.9 0.0 9.7e-27 93.6 0.0 1.7 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 VDK80183.1 - 0.00022 21.5 0.0 0.0004 20.7 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain UCH PF00443.29 VDK80186.1 - 7.4e-48 163.3 0.1 9.2e-48 163.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK80186.1 - 4e-12 46.4 0.1 7e-06 25.9 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 VDK80186.1 - 2.4e-07 30.4 0.0 7.7e-07 28.8 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin family Peptidase_C98 PF15499.6 VDK80186.1 - 0.029 13.9 0.0 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Prenyltransf PF01255.19 VDK80188.1 - 6.6e-63 212.2 0.1 1.4e-62 211.2 0.1 1.5 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Med14 PF08638.11 VDK80188.1 - 0.11 11.8 1.1 0.57 9.6 0.0 2.2 2 0 0 2 2 2 0 Mediator complex subunit MED14 ABA_GPCR PF12430.8 VDK80189.1 - 4.4e-12 46.1 0.9 1.5e-11 44.4 0.9 1.7 1 1 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 VDK80190.1 - 1.1e-27 95.8 0.1 2.1e-27 95.0 0.1 1.4 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal Beta_lactamase3 PF17030.5 VDK80192.1 - 0.0016 17.7 1.1 0.0017 17.6 1.1 1.0 1 0 0 1 1 1 1 Putative beta-lactamase-like family SKA1 PF07160.12 VDK80196.1 - 0.0032 17.4 0.7 0.016 15.1 0.7 2.3 1 1 0 1 1 1 1 Spindle and kinetochore-associated protein 1 zf-HIT PF04438.16 VDK80198.1 - 5.7e-11 42.1 9.9 8.8e-11 41.5 9.9 1.3 1 0 0 1 1 1 1 HIT zinc finger DPRP PF04244.13 VDK80198.1 - 0.035 14.0 2.6 0.17 11.7 2.6 1.9 1 1 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein zf-MYND PF01753.18 VDK80198.1 - 0.94 9.6 10.3 1.7 8.8 10.3 1.4 1 0 0 1 1 1 0 MYND finger PID_2 PF14719.6 VDK80201.1 - 2.8e-79 265.2 2.0 3.6e-79 264.8 2.0 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) WW PF00397.26 VDK80202.1 - 1.6e-12 47.3 9.4 6.3e-10 39.0 1.7 2.7 2 0 0 2 2 2 2 WW domain Phostensin_N PF13916.6 VDK80202.1 - 0.11 12.8 0.3 0.11 12.8 0.3 2.0 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal Jiv90 PF14901.6 VDK80211.1 - 7.7e-36 122.1 7.0 1.9e-35 120.9 7.0 1.7 1 0 0 1 1 1 1 Cleavage inducing molecular chaperone DnaJ PF00226.31 VDK80211.1 - 8.2e-16 57.9 0.4 3.3e-14 52.8 0.2 2.8 2 0 0 2 2 2 1 DnaJ domain BTB PF00651.31 VDK80212.1 - 8.6e-09 35.6 0.0 2.4e-08 34.2 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 VDK80212.1 - 1.3e-07 31.7 28.1 0.011 16.1 1.5 5.3 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK80212.1 - 0.012 16.4 2.0 0.012 16.4 2.0 6.3 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 VDK80212.1 - 0.13 12.3 8.3 0.44 10.6 0.7 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK80212.1 - 0.79 10.1 29.1 0.98 9.8 0.1 5.9 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 VDK80212.1 - 6.1 6.7 29.1 0.12 12.2 0.8 5.3 5 0 0 5 5 5 0 zinc-finger C2H2-type Peptidase_S8 PF00082.22 VDK80230.1 - 1.1e-45 156.2 2.5 1.6e-45 155.7 2.5 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 VDK80230.1 - 5.8e-23 80.7 0.1 1e-22 79.9 0.1 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 VDK80230.1 - 1.5e-13 51.3 3.3 3.4e-13 50.2 3.3 1.6 1 0 0 1 1 1 1 Peptidase S8 pro-domain Furin-like_2 PF15913.5 VDK80232.1 - 0.0033 17.6 17.5 0.0033 17.6 17.5 2.5 1 1 1 2 2 2 1 Furin-like repeat, cysteine-rich DUF3285 PF11688.8 VDK80232.1 - 0.31 11.0 1.9 0.67 9.9 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) RRF PF01765.19 VDK80233.1 - 1e-17 64.5 3.3 1e-17 64.5 3.3 1.5 2 0 0 2 2 2 1 Ribosome recycling factor DUF488 PF04343.13 VDK80233.1 - 0.015 15.9 0.4 0.038 14.6 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF488 nsp8 PF08717.10 VDK80233.1 - 0.021 14.7 1.4 0.039 13.8 1.4 1.4 1 0 0 1 1 1 0 nsp8 replicase DUF4412 PF14371.6 VDK80233.1 - 0.024 14.5 0.2 0.043 13.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4412) Csm2_III-A PF03750.13 VDK80234.1 - 0.1 13.5 0.8 0.45 11.4 0.2 2.1 1 1 1 2 2 2 0 Csm2 Type III-A V-ATPase_C PF03223.15 VDK80235.1 - 2.1e-54 185.4 5.1 2.5e-54 185.1 5.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C MannoseP_isomer PF01050.18 VDK80235.1 - 0.057 13.3 0.2 11 5.9 0.0 2.2 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase Proteasome PF00227.26 VDK80236.1 - 8.5e-34 116.7 0.0 1e-33 116.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF3912 PF13051.6 VDK80236.1 - 0.12 12.7 0.2 0.41 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3912) Ribosomal_L34e PF01199.18 VDK80237.1 - 5.6e-38 129.1 6.3 7.2e-38 128.8 6.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e DZF PF07528.14 VDK80238.1 - 1.5e-51 175.4 0.1 1.5e-51 175.4 0.1 1.7 2 0 0 2 2 2 1 DZF domain zf-met PF12874.7 VDK80238.1 - 1.7e-20 72.7 19.5 5.8e-07 29.7 1.8 3.9 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK80238.1 - 2e-15 56.6 21.4 1e-05 25.7 2.9 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDK80238.1 - 4.2e-05 23.8 19.6 0.5 10.7 3.6 4.3 3 1 1 4 4 4 3 C2H2 type zinc-finger (2 copies) LAL_C2 PF18603.1 VDK80238.1 - 0.0023 18.1 1.4 0.013 15.7 1.4 2.3 1 0 0 1 1 1 1 L-amino acid ligase C-terminal domain 2 zf-C2H2_4 PF13894.6 VDK80238.1 - 0.19 12.6 11.5 4.6 8.3 0.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger DUF3449 PF11931.8 VDK80238.1 - 0.24 11.2 0.1 0.24 11.2 0.1 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3449) zf-C2H2 PF00096.26 VDK80238.1 - 0.35 11.4 18.5 3 8.5 1.8 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-DBF PF07535.12 VDK80238.1 - 0.48 10.6 17.4 3.2 7.9 3.0 3.5 3 0 0 3 3 3 0 DBF zinc finger zf-U1 PF06220.12 VDK80238.1 - 0.82 9.5 17.4 2.2 8.1 2.0 3.5 3 0 0 3 3 3 0 U1 zinc finger HEAT PF02985.22 VDK80250.1 - 1.1e-11 44.0 5.1 0.25 11.7 0.1 6.4 5 0 0 5 5 5 4 HEAT repeat HEAT_2 PF13646.6 VDK80250.1 - 1.5e-09 38.1 4.5 0.0017 18.7 0.1 4.7 3 1 0 4 4 4 2 HEAT repeats Cnd1 PF12717.7 VDK80250.1 - 2.3e-06 27.8 2.4 0.021 14.8 0.0 3.5 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 VDK80250.1 - 0.0072 16.5 0.2 8.8 6.6 0.0 3.6 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 VDK80250.1 - 0.1 13.1 5.9 43 4.8 0.0 4.7 4 1 1 5 5 5 0 HEAT-like repeat HEAT_PBS PF03130.16 VDK80250.1 - 0.12 13.1 1.4 57 4.8 0.1 4.2 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Iso_dh PF00180.20 VDK80252.1 - 4.7e-78 262.8 0.0 5.4e-78 262.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phe_ZIP PF08916.11 VDK80252.1 - 0.14 12.9 0.9 3.3 8.5 0.2 2.4 2 0 0 2 2 2 0 Phenylalanine zipper DEAD PF00270.29 VDK80253.1 - 2.1e-22 79.7 0.0 4.7e-22 78.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK80253.1 - 2.3e-21 76.2 0.4 2e-20 73.2 0.2 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK80253.1 - 0.00071 19.6 0.1 0.0022 18.0 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Methyltr_RsmB-F PF01189.17 VDK80254.1 - 4.3e-37 127.7 0.0 5.8e-36 124.0 0.0 2.2 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 VDK80254.1 - 0.00041 20.5 0.0 0.001 19.2 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase UPF1_Zn_bind PF09416.10 VDK80255.1 - 2.2e-70 235.5 4.2 3.6e-69 231.6 3.2 2.5 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 VDK80255.1 - 6.5e-59 198.9 0.0 1.1e-58 198.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 VDK80255.1 - 2.5e-41 142.2 7.5 2.2e-21 76.8 2.0 2.4 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 VDK80255.1 - 1.1e-28 99.2 0.0 2.3e-28 98.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 VDK80255.1 - 7.6e-16 58.4 0.3 6.9e-15 55.3 0.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 VDK80255.1 - 1.4e-12 48.1 0.4 3e-12 47.1 0.4 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 VDK80255.1 - 3.6e-06 27.1 0.0 7.8e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 VDK80255.1 - 0.00025 21.0 0.0 0.00063 19.7 0.0 1.8 1 1 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 VDK80255.1 - 0.00034 20.2 0.0 0.0091 15.5 0.1 2.3 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 VDK80255.1 - 0.00043 20.1 0.2 0.72 9.6 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 VDK80255.1 - 0.00085 18.7 0.1 0.0055 16.0 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 VDK80255.1 - 0.0015 19.0 0.3 0.0036 17.7 0.3 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 VDK80255.1 - 0.0027 18.0 0.1 0.052 13.8 0.1 2.8 2 1 0 2 2 2 1 AAA domain DEAD PF00270.29 VDK80255.1 - 0.0044 16.8 0.1 0.0081 15.9 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase PhoH PF02562.16 VDK80255.1 - 0.0088 15.5 0.1 0.03 13.8 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein SRP54 PF00448.22 VDK80255.1 - 0.012 15.3 0.1 0.026 14.1 0.1 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase PF06745.13 VDK80255.1 - 0.014 14.8 0.0 0.098 12.0 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_10 PF12846.7 VDK80255.1 - 0.015 14.2 0.0 0.029 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain UvrD_C_2 PF13538.6 VDK80255.1 - 0.057 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Herpes_ori_bp PF02399.15 VDK80255.1 - 0.087 10.9 0.0 0.14 10.2 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein PIF1 PF05970.14 VDK80255.1 - 0.1 11.8 0.1 3.8 6.6 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase DUF4148 PF13663.6 VDK80257.1 - 0.29 11.4 6.3 0.91 9.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4148) ubiquitin PF00240.23 VDK80259.1 - 5.9e-28 96.4 0.2 6.5e-28 96.3 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 VDK80259.1 - 2.7e-15 56.0 0.2 2.9e-15 55.8 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 VDK80259.1 - 3.4e-05 24.2 0.0 0.0001 22.7 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 VDK80259.1 - 0.00028 20.7 0.0 0.00032 20.6 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 VDK80259.1 - 0.027 14.6 0.1 0.079 13.1 0.1 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Tetraspanin PF00335.20 VDK80260.1 - 1.6e-33 116.3 6.1 1.9e-33 116.1 6.1 1.1 1 0 0 1 1 1 1 Tetraspanin family LapA_dom PF06305.11 VDK80260.1 - 0.099 12.5 1.4 2.2 8.2 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Astacin PF01400.24 VDK80262.1 - 6.6e-15 55.2 0.0 1.8e-14 53.8 0.0 1.7 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Kelch_1 PF01344.25 VDK80273.1 - 1e-29 101.8 18.0 5.1e-07 29.2 0.6 6.6 7 0 0 7 7 7 5 Kelch motif Kelch_5 PF13854.6 VDK80273.1 - 2.8e-29 100.6 7.7 3e-05 23.9 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 VDK80273.1 - 3.6e-26 90.1 8.6 2.8e-06 27.1 0.1 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 VDK80273.1 - 3.8e-25 87.6 7.9 2.3e-05 24.3 0.0 6.1 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 VDK80273.1 - 1.9e-20 72.4 9.0 1e-08 35.2 0.1 6.9 7 0 0 7 7 7 4 Kelch motif Kelch_3 PF13415.6 VDK80273.1 - 3.8e-20 71.7 2.6 0.00092 19.4 0.0 7.2 8 0 0 8 8 8 4 Galactose oxidase, central domain Haspin_kinase PF12330.8 VDK80274.1 - 2e-55 188.3 2.6 3.1e-55 187.6 2.6 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase PF00069.25 VDK80274.1 - 1e-07 31.6 0.4 3.5e-06 26.6 0.4 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80274.1 - 0.00086 18.7 0.2 0.006 15.9 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase MNSV_P7B PF06692.11 VDK80274.1 - 0.18 11.9 0.1 7.8 6.6 0.0 2.5 2 0 0 2 2 2 0 Melon necrotic spot virus P7B protein Peptidase_M28 PF04389.17 VDK80275.1 - 1.9e-46 158.2 0.0 2.8e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 VDK80275.1 - 0.0033 17.1 0.0 0.0044 16.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 VDK80275.1 - 0.044 12.8 0.0 0.4 9.6 0.0 2.0 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase START PF01852.19 VDK80278.1 - 2.6e-17 63.0 0.1 3.7e-17 62.4 0.1 1.2 1 0 0 1 1 1 1 START domain CSN5_C PF18323.1 VDK80278.1 - 0.089 13.7 0.4 0.18 12.8 0.4 1.4 1 0 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain Phytochelatin PF05023.14 VDK80280.1 - 1.2e-85 286.1 0.0 1.5e-85 285.8 0.0 1.0 1 0 0 1 1 1 1 Phytochelatin synthase HTH_26 PF13443.6 VDK80280.1 - 0.032 14.7 0.0 0.084 13.3 0.0 1.7 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain Peptidase_C39_2 PF13529.6 VDK80280.1 - 0.16 12.5 0.1 1.4 9.5 0.1 2.1 1 1 0 1 1 1 0 Peptidase_C39 like family Pkinase_Tyr PF07714.17 VDK80291.1 - 5.4e-34 117.6 0.0 7.1e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK80291.1 - 3.4e-31 108.6 0.0 4.7e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 VDK80291.1 - 0.096 12.0 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 VDK80291.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Collagen PF01391.18 VDK80292.1 - 2.3e-23 81.7 75.7 9.6e-11 41.3 23.9 3.7 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK80292.1 - 0.053 13.6 0.3 0.093 12.8 0.3 1.4 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Nicastrin PF05450.15 VDK80292.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Nicastrin Sema PF01403.19 VDK80297.1 - 3.8e-105 352.1 0.1 5.9e-104 348.2 0.1 2.0 1 1 0 1 1 1 1 Sema domain PSI PF01437.25 VDK80297.1 - 7.1e-05 23.3 8.7 0.00015 22.2 8.7 1.6 1 0 0 1 1 1 1 Plexin repeat DUF4692 PF15763.5 VDK80297.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Pkinase PF00069.25 VDK80298.1 - 1e-72 244.7 0.0 1.5e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80298.1 - 7.8e-34 117.1 0.0 1.9e-33 115.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase C1_1 PF00130.22 VDK80298.1 - 2.1e-22 78.8 23.1 1.8e-12 46.9 3.5 3.2 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Kdo PF06293.14 VDK80298.1 - 4.1e-07 29.6 0.0 7.9e-07 28.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family C1_2 PF03107.16 VDK80298.1 - 6.3e-07 29.6 11.9 0.00017 21.8 1.7 2.6 2 0 0 2 2 2 2 C1 domain Kinase-like PF14531.6 VDK80298.1 - 2.7e-05 23.6 0.0 4.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PHD_2 PF13831.6 VDK80298.1 - 0.006 16.1 10.0 0.14 11.8 1.6 3.2 3 0 0 3 3 3 2 PHD-finger Pkinase_fungal PF17667.1 VDK80298.1 - 0.0066 15.3 0.0 0.02 13.7 0.0 1.5 1 1 0 1 1 1 1 Fungal protein kinase Spike_torovirin PF17072.5 VDK80298.1 - 0.0074 13.5 0.0 0.01 13.0 0.0 1.1 1 0 0 1 1 1 1 Torovirinae spike glycoprotein PHD PF00628.29 VDK80298.1 - 0.041 13.8 19.0 0.44 10.5 4.1 2.7 2 0 0 2 2 2 0 PHD-finger FYVE_2 PF02318.16 VDK80298.1 - 0.18 12.0 14.4 1.3 9.3 3.3 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger Prok-RING_1 PF14446.6 VDK80298.1 - 6.1 6.8 15.8 4.7 7.2 2.7 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 TF_AP-2 PF03299.14 VDK80301.1 - 6.8e-80 267.7 3.1 1.2e-79 266.8 0.0 2.2 2 0 0 2 2 2 1 Transcription factor AP-2 DUF3599 PF12206.8 VDK80301.1 - 0.0055 17.1 2.4 0.012 15.9 2.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3599) VasI PF11319.8 VDK80301.1 - 0.022 14.4 5.4 0.044 13.5 5.4 1.5 1 0 0 1 1 1 0 Type VI secretion system VasI, EvfG, VC_A0118 EPL1 PF10513.9 VDK80301.1 - 0.1 13.0 2.9 0.16 12.3 2.9 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Med15 PF09606.10 VDK80301.1 - 0.39 9.4 22.7 0.57 8.8 22.7 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 VDK80301.1 - 0.83 9.6 25.0 1.2 9.1 25.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cellulose_synt PF03552.14 VDK80301.1 - 1.2 7.5 2.7 1.7 7.1 2.7 1.1 1 0 0 1 1 1 0 Cellulose synthase Presenilin PF01080.17 VDK80301.1 - 4.9 5.8 7.1 6.3 5.5 7.1 1.1 1 0 0 1 1 1 0 Presenilin Pribosyl_synth PF14572.6 VDK80305.1 - 1.7e-93 311.8 0.3 2.5e-93 311.2 0.3 1.3 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 VDK80305.1 - 1.4e-38 131.4 0.5 2.8e-38 130.4 0.5 1.5 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 VDK80305.1 - 2e-06 27.4 0.2 7.7e-06 25.5 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase domain GRAM PF02893.20 VDK80306.1 - 1.6e-09 37.6 0.0 3.9e-09 36.4 0.0 1.6 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.8 VDK80306.1 - 0.00033 20.8 0.0 0.00082 19.5 0.0 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 MgtE PF01769.16 VDK80307.1 - 1.8e-43 147.8 25.7 1.4e-23 83.6 3.7 2.9 3 0 0 3 3 3 2 Divalent cation transporter Aminotran_1_2 PF00155.21 VDK80308.1 - 2.7e-67 227.5 0.0 3.5e-67 227.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 VDK80308.1 - 0.0013 17.4 0.0 0.0019 16.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 VDK80308.1 - 0.0019 17.2 0.0 0.0028 16.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 VDK80308.1 - 0.0056 16.0 0.0 0.012 14.9 0.0 1.5 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family HATPase_c_5 PF14501.6 VDK80308.1 - 0.052 13.4 0.1 0.099 12.6 0.1 1.5 1 0 0 1 1 1 0 GHKL domain Flg_hook PF02120.16 VDK80308.1 - 0.13 12.1 0.0 5.8 6.9 0.0 2.9 3 0 0 3 3 3 0 Flagellar hook-length control protein FliK Pro_dh PF01619.18 VDK80311.1 - 7.7e-71 239.0 7.3 1.4e-70 238.2 7.3 1.6 1 1 0 1 1 1 1 Proline dehydrogenase PPR_3 PF13812.6 VDK80311.1 - 0.0023 18.0 0.1 0.025 14.6 0.0 2.7 2 0 0 2 2 2 1 Pentatricopeptide repeat domain DUF2242 PF10001.9 VDK80311.1 - 0.015 15.4 0.1 0.37 11.0 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2242) SufE PF02657.15 VDK80311.1 - 0.033 14.0 0.0 0.2 11.5 0.0 2.3 2 0 0 2 2 2 0 Fe-S metabolism associated domain DUF424 PF04242.13 VDK80311.1 - 0.049 13.9 0.1 0.13 12.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF424) Pkinase PF00069.25 VDK80313.1 - 8.1e-57 192.6 0.0 1e-56 192.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80313.1 - 1.1e-41 142.9 0.0 1.4e-41 142.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK80313.1 - 6.4e-06 25.7 0.0 9.7e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK80313.1 - 0.0023 16.8 0.1 0.006 15.4 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 VDK80313.1 - 0.0028 16.8 0.0 0.0047 16.0 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 VDK80313.1 - 0.0047 15.9 0.1 0.012 14.6 0.1 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 VDK80313.1 - 0.075 12.0 0.2 0.11 11.4 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 VDK80313.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family ABC_membrane_2 PF06472.15 VDK80314.1 - 1e-57 195.6 0.2 1.5e-57 195.0 0.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 VDK80314.1 - 9.3e-18 65.1 0.0 2.2e-17 63.9 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 VDK80314.1 - 0.00041 20.3 0.0 0.00076 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 VDK80314.1 - 0.0025 17.3 0.2 0.11 12.0 0.1 2.4 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 VDK80314.1 - 0.0091 16.5 1.5 0.013 16.0 0.3 1.8 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 VDK80314.1 - 0.018 14.7 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 VDK80314.1 - 0.025 14.5 0.1 0.28 11.1 0.0 2.4 2 0 0 2 2 2 0 Rad17 P-loop domain ABC_membrane PF00664.23 VDK80314.1 - 0.062 12.9 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 ABC transporter transmembrane region MqsR_toxin PF15723.5 VDK80314.1 - 0.13 12.6 0.0 0.44 10.9 0.0 1.8 2 0 0 2 2 2 0 Motility quorum-sensing regulator, toxin of MqsA Tetraspanin PF00335.20 VDK80323.1 - 1.3e-38 133.1 11.8 1.6e-38 132.7 11.8 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF3810 PF12725.7 VDK80323.1 - 0.022 14.1 0.3 0.049 13.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Neurensin PF14927.6 VDK80323.1 - 0.13 12.0 0.3 0.89 9.3 0.0 2.3 1 1 1 2 2 2 0 Neurensin TctB PF07331.11 VDK80323.1 - 0.39 11.0 8.2 0.94 9.8 8.2 1.6 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF2207 PF09972.9 VDK80323.1 - 2.1 7.0 4.8 13 4.4 4.9 2.1 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MgtE PF01769.16 VDK80323.1 - 3 8.3 10.6 4.9 7.5 8.1 2.2 2 1 0 2 2 2 0 Divalent cation transporter Ribosomal_L35p PF01632.19 VDK80324.1 - 0.083 13.4 1.0 0.11 13.0 1.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L35 Pkinase PF00069.25 VDK80325.1 - 5.9e-54 183.2 0.0 7.1e-54 182.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80325.1 - 5.5e-40 137.3 0.0 7.3e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK80325.1 - 2.7e-07 30.2 0.2 7.4e-07 28.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 VDK80325.1 - 0.0031 16.6 0.1 0.007 15.5 0.1 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 Haspin_kinase PF12330.8 VDK80325.1 - 0.024 13.6 0.0 0.043 12.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 VDK80325.1 - 0.14 10.9 0.0 0.27 10.0 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase HAGH_C PF16123.5 VDK80327.1 - 6.4e-26 90.7 0.3 1.2e-25 89.8 0.3 1.4 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 VDK80327.1 - 3e-11 43.7 0.5 3.9e-06 27.0 0.1 2.4 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily DAGK_cat PF00781.24 VDK80327.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Lactamase_B_3 PF13483.6 VDK80327.1 - 0.014 15.3 0.1 0.028 14.3 0.1 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Stathmin PF00836.19 VDK80327.1 - 0.02 14.9 0.1 0.033 14.2 0.1 1.3 1 0 0 1 1 1 0 Stathmin family BcrAD_BadFG PF01869.20 VDK80327.1 - 0.059 12.9 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Tetraspanin PF00335.20 VDK80328.1 - 8e-27 94.4 9.3 1e-26 94.1 9.3 1.0 1 0 0 1 1 1 1 Tetraspanin family COX1 PF00115.20 VDK80328.1 - 0.00045 19.2 11.4 0.026 13.4 5.7 2.2 2 0 0 2 2 2 2 Cytochrome C and Quinol oxidase polypeptide I MLANA PF14991.6 VDK80328.1 - 0.027 14.8 0.1 0.057 13.7 0.1 1.5 1 0 0 1 1 1 0 Protein melan-A Nramp PF01566.18 VDK80329.1 - 1.1e-96 324.0 5.3 2.1e-96 323.0 5.3 1.5 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein UPF0182 PF03699.13 VDK80329.1 - 1.1 7.3 6.8 0.11 10.6 1.7 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0182) Tmpp129 PF10272.9 VDK80330.1 - 1.7e-104 350.0 5.6 2.2e-104 349.6 5.6 1.1 1 0 0 1 1 1 1 Putative transmembrane protein precursor IBR PF01485.21 VDK80330.1 - 4.3 7.6 9.9 18 5.7 9.9 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Histone PF00125.24 VDK80333.1 - 7.6e-54 181.6 1.6 8.5e-54 181.4 1.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 VDK80333.1 - 7.9e-05 22.7 0.2 0.00017 21.7 0.0 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 VDK80333.1 - 0.00015 22.3 2.4 0.00019 22.0 2.4 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 VDK80333.1 - 0.00028 21.2 0.0 0.00042 20.6 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 VDK80333.1 - 0.054 13.8 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone 4_1_CTD PF05902.13 VDK80339.1 - 0.35 10.9 9.6 0.78 9.8 8.1 2.3 2 0 0 2 2 2 0 4.1 protein C-terminal domain (CTD) IQCJ-SCHIP1 PF15157.6 VDK80339.1 - 5.8 6.7 7.2 15 5.4 7.2 1.7 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif fn3 PF00041.21 VDK80341.1 - 7.5e-35 119.2 0.3 9e-15 54.8 0.0 3.4 3 0 0 3 3 3 3 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK80341.1 - 2.9e-08 34.2 0.1 4.5e-05 24.0 0.0 3.2 3 0 0 3 3 3 2 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 VDK80344.1 - 9.5e-57 189.3 6.4 4.6e-16 58.9 0.7 5.4 4 1 0 4 4 4 4 Fibronectin type III domain Ig_3 PF13927.6 VDK80344.1 - 2.9e-34 117.5 0.5 1.9e-12 47.6 0.0 3.9 4 0 0 4 4 3 3 Immunoglobulin domain I-set PF07679.16 VDK80344.1 - 5.7e-34 116.1 0.0 1.6e-14 53.8 0.0 3.6 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_2 PF13895.6 VDK80344.1 - 2.1e-20 72.8 0.1 5.8e-07 29.8 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 VDK80344.1 - 6.3e-18 64.7 0.0 6.6e-05 23.0 0.0 3.8 3 1 0 3 3 3 3 Immunoglobulin domain Pur_ac_phosph_N PF16656.5 VDK80344.1 - 9e-15 55.0 1.2 0.0022 18.5 0.1 4.7 4 0 0 4 4 4 4 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 VDK80344.1 - 2.9e-08 33.7 0.0 0.025 14.6 0.0 3.6 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain V-set PF07686.17 VDK80344.1 - 1.5e-05 25.1 0.8 0.042 14.0 0.0 5.0 5 1 0 5 5 5 1 Immunoglobulin V-set domain Interfer-bind PF09294.10 VDK80344.1 - 0.00016 21.9 0.0 16 5.9 0.1 4.4 5 0 0 5 5 4 0 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 VDK80344.1 - 0.0034 17.7 0.0 2.6 8.5 0.0 3.8 4 0 0 4 4 4 1 Uncharacterised conserved protein (DUF2369) Ig_C17orf99 PF17736.1 VDK80344.1 - 0.0044 17.0 0.2 0.024 14.7 0.0 2.3 3 1 0 3 3 2 1 C17orf99 Ig domain fn3_2 PF16893.5 VDK80344.1 - 0.0082 16.3 0.3 0.27 11.4 0.0 3.4 4 0 0 4 4 4 1 Fibronectin type III domain FAM53 PF15242.6 VDK80344.1 - 0.013 15.3 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 Family of FAM53 Ion_trans_2 PF07885.16 VDK80360.1 - 3.9e-36 122.9 23.0 2.7e-18 65.7 3.5 2.9 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK80360.1 - 5.4e-11 42.2 13.8 1.9e-06 27.3 6.6 2.6 2 1 0 2 2 2 2 Ion transport protein IRK PF01007.20 VDK80360.1 - 0.00018 21.3 1.9 0.4 10.5 0.2 2.6 2 0 0 2 2 2 2 Inward rectifier potassium channel transmembrane domain GAIN PF16489.5 VDK80360.1 - 0.06 12.8 0.1 0.77 9.1 0.1 2.2 2 0 0 2 2 2 0 GPCR-Autoproteolysis INducing (GAIN) domain SAC3 PF12209.8 VDK80360.1 - 0.1 12.8 0.5 0.29 11.3 0.2 1.8 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain DNA_primase_S PF01896.19 VDK80361.1 - 3e-46 157.7 0.2 5.1e-46 156.9 0.2 1.4 1 0 0 1 1 1 1 DNA primase small subunit Band_7 PF01145.25 VDK80361.1 - 0.043 13.8 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 SPFH domain / Band 7 family Collagen PF01391.18 VDK80362.1 - 3.6 7.4 12.9 12 5.8 12.9 2.0 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) Ion_trans_2 PF07885.16 VDK80363.1 - 4.4e-33 113.1 20.1 5.8e-19 67.8 2.9 2.5 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK80363.1 - 6.6e-09 35.4 4.3 0.00039 19.7 0.2 2.1 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 VDK80363.1 - 4.4e-05 23.3 1.8 0.0011 18.8 0.3 2.6 2 0 0 2 2 2 1 Inward rectifier potassium channel transmembrane domain DUF2254 PF10011.9 VDK80363.1 - 0.0017 17.2 1.2 0.0017 17.2 1.2 2.1 2 0 0 2 2 2 1 Predicted membrane protein (DUF2254) Pkinase PF00069.25 VDK80364.1 - 1.6e-22 80.1 0.2 2.6e-22 79.5 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80364.1 - 6.5e-13 48.6 0.0 8.8e-13 48.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK80364.1 - 6.9e-05 21.8 0.3 0.00011 21.1 0.3 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK80364.1 - 0.028 13.8 0.1 0.047 13.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK80364.1 - 0.15 11.9 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 VDK80364.1 - 0.45 9.8 3.0 1.9 7.7 0.1 2.4 3 0 0 3 3 3 0 Kinase-like CSN8_PSD8_EIF3K PF10075.9 VDK80368.1 - 2.2e-29 102.3 0.2 5e-29 101.1 0.1 1.6 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family adh_short PF00106.25 VDK80370.1 - 2.1e-31 108.9 0.0 3.3e-31 108.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK80370.1 - 1.1e-26 93.9 0.2 2.4e-26 92.7 0.1 1.6 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK80370.1 - 2.8e-13 50.1 0.0 6.3e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 KR domain Rad60-SLD PF11976.8 VDK80372.1 - 7.4e-14 51.3 1.5 3e-11 43.0 0.1 3.1 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 VDK80372.1 - 0.00091 18.9 0.1 0.02 14.6 0.0 2.8 3 0 0 3 3 3 1 Ubiquitin family DnaJ PF00226.31 VDK80373.1 - 8.3e-22 77.1 3.3 1.3e-21 76.5 2.6 1.8 2 0 0 2 2 2 1 DnaJ domain DUF4216 PF13952.6 VDK80373.1 - 0.034 14.5 0.1 0.63 10.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4216) Ras PF00071.22 VDK80374.1 - 5.3e-50 169.2 0.0 6.7e-50 168.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK80374.1 - 5.6e-31 107.2 0.1 1.3e-30 106.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK80374.1 - 7.5e-11 41.8 0.0 1e-10 41.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 VDK80374.1 - 6.4e-05 23.3 0.1 0.00031 21.1 0.1 2.0 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 VDK80374.1 - 0.00016 21.7 0.0 0.0003 20.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK80374.1 - 0.0017 17.8 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 VDK80374.1 - 0.0025 17.4 0.6 0.012 15.2 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 VDK80374.1 - 0.0053 16.5 0.0 0.0091 15.7 0.0 1.4 1 1 0 1 1 1 1 AAA domain Pox_A32 PF04665.12 VDK80374.1 - 0.026 14.0 0.1 0.049 13.1 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein RsgA_GTPase PF03193.16 VDK80374.1 - 0.035 14.0 0.1 8.1 6.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Septin PF00735.18 VDK80374.1 - 0.038 13.3 0.0 0.073 12.3 0.0 1.4 1 0 0 1 1 1 0 Septin AAA_7 PF12775.7 VDK80374.1 - 0.038 13.5 0.1 0.065 12.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ArgoMid PF16487.5 VDK80374.1 - 0.045 14.0 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 Mid domain of argonaute AAA_33 PF13671.6 VDK80374.1 - 0.092 12.9 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain GCD14_N PF14801.6 VDK80374.1 - 0.096 12.5 0.5 9.3 6.2 0.1 2.3 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit N-term AAA_16 PF13191.6 VDK80374.1 - 0.1 12.9 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 VDK80374.1 - 0.11 12.5 0.1 0.25 11.3 0.1 1.5 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE G-alpha PF00503.20 VDK80374.1 - 0.12 11.5 3.4 2.2 7.3 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit ATP_bind_1 PF03029.17 VDK80374.1 - 0.17 11.6 0.1 10 5.8 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DKCLD PF08068.12 VDK80375.1 - 2.4e-32 110.8 0.1 1.1e-31 108.7 0.2 2.0 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 VDK80375.1 - 6.8e-22 77.4 0.4 1.2e-21 76.5 0.4 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 VDK80375.1 - 1.4e-18 66.6 1.4 2.5e-18 65.8 1.4 1.4 1 0 0 1 1 1 1 PUA domain TruB_N PF01509.18 VDK80375.1 - 4.9e-10 40.0 0.9 0.00026 21.4 0.1 3.5 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) UPF0113 PF03657.13 VDK80375.1 - 0.0031 17.7 0.1 0.0076 16.5 0.1 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain DUF1899 PF08953.11 VDK80376.1 - 8.3e-28 96.1 0.1 1.9e-27 94.9 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 VDK80376.1 - 5.2e-16 58.3 0.1 9.4e-16 57.4 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 VDK80376.1 - 8.5e-14 51.7 3.0 0.0056 17.5 0.2 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK80376.1 - 3.6e-07 30.4 0.9 0.012 15.9 0.0 3.9 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Calponin PF00402.18 VDK80385.1 - 3.7e-62 205.5 30.2 1.9e-13 49.8 2.2 7.3 7 0 0 7 7 7 7 Calponin family repeat TPR_2 PF07719.17 VDK80386.1 - 2e-30 102.4 2.2 0.00049 20.0 0.0 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 VDK80386.1 - 1.2e-25 88.3 7.3 0.0082 15.9 0.0 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_14 PF13428.6 VDK80386.1 - 1.1e-18 66.3 0.0 0.3 12.0 0.0 8.3 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDK80386.1 - 1.1e-16 59.6 0.4 0.007 16.5 0.0 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 VDK80386.1 - 1.9e-14 52.9 1.7 1.7 9.2 0.0 7.9 7 2 1 8 8 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 VDK80386.1 - 3.1e-14 53.2 0.0 0.061 13.8 0.0 5.5 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK80386.1 - 1.3e-12 47.8 6.2 0.018 15.3 0.0 6.7 3 1 3 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK80386.1 - 5.1e-11 42.7 12.9 0.014 15.6 0.3 4.7 4 1 1 5 5 5 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 VDK80386.1 - 2.5e-09 37.6 0.0 0.58 10.8 0.0 5.3 3 1 4 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 VDK80386.1 - 8.5e-08 31.7 2.8 25 5.2 0.0 8.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_9 PF13371.6 VDK80386.1 - 2.1e-06 27.8 0.4 0.86 9.8 0.0 5.4 4 1 3 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 VDK80386.1 - 2.3e-06 27.8 3.0 60 4.6 0.0 7.3 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 VDK80386.1 - 0.00015 21.5 0.5 0.87 9.5 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK80386.1 - 0.00019 21.0 1.1 13 5.6 0.1 5.8 6 1 3 9 9 9 0 TPR repeat TPR_15 PF13429.6 VDK80386.1 - 0.0042 16.3 0.0 0.14 11.3 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat E2F_CC-MB PF16421.5 VDK80386.1 - 0.0058 17.0 0.0 0.021 15.2 0.0 2.0 2 0 0 2 2 1 1 E2F transcription factor CC-MB domain TPR_MalT PF17874.1 VDK80386.1 - 0.0072 15.7 0.0 1 8.7 0.0 3.1 3 1 0 3 3 3 1 MalT-like TPR region Fis1_TPR_C PF14853.6 VDK80386.1 - 0.0073 16.4 2.6 1.1 9.4 0.0 4.3 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat ChAPs PF09295.10 VDK80386.1 - 0.017 14.1 0.0 1.2 8.1 0.0 2.3 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) PNKP-ligase_C PF16536.5 VDK80386.1 - 0.086 13.1 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, C-terminal region ShK PF01549.24 VDK80390.1 - 3.9e-12 46.5 51.5 3.2e-06 27.6 8.8 5.7 6 1 0 6 6 6 3 ShK domain-like Baculo_LEF-10 PF07206.11 VDK80390.1 - 3.8 7.8 6.0 9.9 6.4 1.7 2.8 3 0 0 3 3 3 0 Baculovirus late expression factor 10 (LEF-10) Bax1-I PF01027.20 VDK80391.1 - 6.4e-22 78.4 38.0 9.4e-22 77.9 38.0 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CLASP_N PF12348.8 VDK80391.1 - 4.5e-14 52.6 7.0 2.4e-07 30.6 0.1 3.3 4 0 0 4 4 4 2 CLASP N terminal HEAT PF02985.22 VDK80391.1 - 2e-09 36.9 4.3 0.0035 17.5 0.0 5.3 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 VDK80391.1 - 7e-08 32.7 3.3 0.24 11.8 0.0 4.5 4 0 0 4 4 4 3 HEAT repeats Cnd1 PF12717.7 VDK80391.1 - 1.1e-05 25.5 14.2 0.45 10.5 0.3 5.5 5 0 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 VDK80391.1 - 0.00023 21.7 1.0 3.7 8.2 0.0 4.7 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 VDK80391.1 - 0.0006 19.6 0.3 6.5 6.5 0.0 4.4 5 0 0 5 5 5 1 rRNA processing/ribosome biogenesis HEAT_EZ PF13513.6 VDK80391.1 - 0.028 14.9 0.5 15 6.3 0.0 4.2 4 0 0 4 4 4 0 HEAT-like repeat CNOT11 PF10155.9 VDK80391.1 - 0.11 12.6 0.7 2.9 8.1 0.0 2.9 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 11 CLASP_N PF12348.8 VDK80393.1 - 1.5e-14 54.2 7.1 1.5e-07 31.2 0.1 3.4 4 0 0 4 4 4 2 CLASP N terminal HEAT PF02985.22 VDK80393.1 - 5.1e-10 38.7 4.3 0.0025 17.9 0.0 5.3 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 VDK80393.1 - 1.7e-08 34.8 3.3 0.17 12.3 0.0 4.7 4 0 0 4 4 4 3 HEAT repeats Cnd1 PF12717.7 VDK80393.1 - 1.1e-06 28.7 13.7 0.31 11.1 0.3 5.7 5 0 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 VDK80393.1 - 0.00017 21.4 0.6 4.5 7.0 0.0 4.7 5 0 0 5 5 5 1 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.7 VDK80393.1 - 0.00021 21.8 2.5 2.5 8.7 0.0 4.7 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 VDK80393.1 - 0.012 16.1 0.9 10 6.7 0.0 4.3 4 0 0 4 4 4 0 HEAT-like repeat CNOT11 PF10155.9 VDK80393.1 - 0.049 13.8 0.7 2 8.6 0.0 3.0 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 11 tRNA_lig_kinase PF08303.11 VDK80393.1 - 0.072 13.2 0.6 1.2 9.2 0.0 3.2 3 0 0 3 3 3 0 tRNA ligase kinase domain RTP1_C1 PF10363.9 VDK80393.1 - 0.098 12.8 0.2 0.99 9.6 0.0 2.9 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 zf-C2H2 PF00096.26 VDK80406.1 - 0.016 15.7 13.1 0.078 13.5 0.5 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK80406.1 - 0.13 13.2 11.7 0.88 10.6 0.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger DZR PF12773.7 VDK80406.1 - 0.33 11.0 3.4 0.8 9.8 3.4 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-C2H2_jaz PF12171.8 VDK80406.1 - 0.89 9.9 10.3 4.4 7.7 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Vps39_2 PF10367.9 VDK80406.1 - 1.2 9.6 7.3 0.22 12.0 2.0 2.2 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 Nop52 PF05997.12 VDK80408.1 - 1.4e-54 185.2 3.2 1.4e-54 185.2 3.2 1.9 1 1 1 2 2 2 1 Nucleolar protein,Nop52 DUF4179 PF13786.6 VDK80408.1 - 0.049 14.1 0.0 0.25 11.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) MFS_1 PF07690.16 VDK80409.1 - 1.4e-24 86.7 36.6 1.6e-24 86.5 26.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 VDK80409.1 - 8.6e-09 34.8 15.5 8.6e-09 34.8 15.5 1.9 1 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 VDK80409.1 - 0.0088 14.4 16.8 0.68 8.1 1.6 3.6 1 1 2 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family TPR_11 PF13414.6 VDK80412.1 - 4.6e-14 51.8 2.4 0.0036 16.9 0.0 6.0 5 0 0 5 5 5 3 TPR repeat TPR_2 PF07719.17 VDK80412.1 - 3.6e-13 48.5 27.3 1.8e-05 24.5 1.8 8.8 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 VDK80412.1 - 1.1e-12 47.6 11.4 0.00048 20.7 0.1 8.3 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK80412.1 - 4e-10 40.0 4.8 0.0033 17.9 0.0 7.0 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK80412.1 - 7.3e-10 38.3 27.1 3.3e-05 23.7 0.8 9.2 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK80412.1 - 7.6e-10 38.2 17.5 0.0053 16.5 1.2 6.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 VDK80412.1 - 2.5e-09 37.6 17.7 0.052 14.2 0.0 8.2 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK80412.1 - 5.3e-09 36.2 25.2 4.5e-05 23.7 0.4 7.2 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 VDK80412.1 - 1.6e-07 31.2 11.2 0.056 13.8 0.0 6.8 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 VDK80412.1 - 9.9e-07 29.0 7.3 1.9 8.9 0.1 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 VDK80412.1 - 1e-05 24.9 1.3 0.1 11.8 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 VDK80412.1 - 9.1e-05 22.5 10.6 0.14 12.3 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK80412.1 - 0.00096 19.3 10.0 0.022 14.9 1.2 4.9 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 VDK80412.1 - 0.0044 16.0 5.8 0.26 10.2 0.3 3.4 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_6 PF13174.6 VDK80412.1 - 0.0044 17.6 10.7 19 6.2 0.0 6.7 7 0 0 7 7 6 0 Tetratricopeptide repeat Coatomer_E PF04733.14 VDK80412.1 - 0.013 14.9 0.1 5.6 6.3 0.0 3.0 2 1 0 2 2 2 0 Coatomer epsilon subunit MIT PF04212.18 VDK80412.1 - 0.37 10.9 2.8 0.49 10.5 0.1 2.7 2 0 0 2 2 1 0 MIT (microtubule interacting and transport) domain TPR_4 PF07721.14 VDK80412.1 - 1.2 10.0 7.7 32 5.6 0.1 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK80412.1 - 2.2 8.5 10.3 44 4.4 0.1 6.2 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 VDK80412.1 - 9.8 6.2 18.5 0.66 9.9 1.1 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 VDK80414.1 - 1.1e-10 41.5 0.2 3e-05 24.0 0.0 2.3 1 1 1 2 2 2 2 Mad3/BUB1 homology region 1 RNA_pol_Rbc25 PF08292.12 VDK80415.1 - 9.3e-33 113.2 6.4 4.4e-31 107.8 6.4 2.3 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 VDK80415.1 - 5.4e-19 68.3 0.0 9.7e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 VDK80415.1 - 0.0023 18.2 0.0 0.0071 16.7 0.0 1.9 1 1 0 1 1 1 1 S1 RNA binding domain SET PF00856.28 VDK80427.1 - 1.9e-24 86.9 0.1 7.2e-24 85.1 0.0 2.0 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 VDK80427.1 - 1.3e-15 58.0 5.1 1.3e-15 58.0 5.1 2.6 4 0 0 4 4 4 1 Pre-SET motif MBD PF01429.19 VDK80427.1 - 0.0011 18.6 0.0 0.0027 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyl-CpG binding domain Tudor_4 PF18358.1 VDK80427.1 - 0.0017 17.9 0.2 0.0051 16.4 0.2 1.8 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain Collagen PF01391.18 VDK80428.1 - 1.1e-25 89.2 105.1 3.5e-10 39.5 37.4 4.1 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK80428.1 - 1e-16 60.7 2.3 1.3e-16 60.4 2.3 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Mlh1_C PF16413.5 VDK80429.1 - 1.2e-63 215.0 1.6 2.1e-63 214.2 1.6 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 VDK80429.1 - 1.7e-22 79.3 0.1 3.1e-22 78.5 0.1 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 VDK80429.1 - 7.3e-12 45.3 0.0 1.8e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 VDK80429.1 - 1.8e-06 28.4 0.0 4.8e-06 27.1 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Patched PF02460.18 VDK80430.1 - 7e-184 613.2 17.6 4.6e-182 607.2 17.6 2.0 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK80430.1 - 6e-26 91.1 6.4 6e-26 91.1 6.4 3.5 4 1 0 4 4 4 1 Sterol-sensing domain of SREBP cleavage-activation DUF4791 PF16039.5 VDK80430.1 - 0.059 12.9 1.1 0.12 11.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4791) SecD_SecF PF02355.16 VDK80430.1 - 0.12 11.8 17.6 0.025 14.0 9.3 2.4 2 0 0 2 2 2 0 Protein export membrane protein DUF2627 PF11118.8 VDK80430.1 - 1.5 9.5 4.6 0.43 11.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) VCBS PF13517.6 VDK80432.1 - 1.9e-19 70.0 15.4 4.8e-09 36.7 1.3 5.5 4 1 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 VDK80432.1 - 7.5e-10 38.8 25.7 2.6e-05 24.2 0.0 6.3 6 0 0 6 6 6 3 FG-GAP repeat TcdB_toxin_midN PF12256.8 VDK80432.1 - 0.0081 15.5 1.7 10 5.4 0.0 4.5 5 1 1 6 6 6 2 Insecticide toxin TcdB middle/N-terminal region DUF3290 PF11694.8 VDK80432.1 - 0.031 14.2 0.2 0.071 13.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) POPLD PF08170.12 VDK80434.1 - 1.5e-20 73.3 4.4 2.4e-20 72.6 0.0 2.7 3 0 0 3 3 3 1 POPLD (NUC188) domain POP1 PF06978.11 VDK80434.1 - 5.3e-07 29.8 6.1 5.3e-07 29.8 6.1 2.5 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 GCV_T PF01571.21 VDK80434.1 - 0.00016 21.1 0.0 0.14 11.5 0.0 2.2 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain Ribosomal_S17 PF00366.20 VDK80436.1 - 0.0017 18.5 0.0 0.0044 17.1 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S17 Myb_DNA-bind_7 PF15963.5 VDK80436.1 - 0.068 13.1 0.3 0.14 12.1 0.3 1.5 1 0 0 1 1 1 0 Myb DNA-binding like WD40 PF00400.32 VDK80437.1 - 1.5e-56 187.1 25.1 5.1e-08 33.5 0.0 8.0 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK80437.1 - 5.4e-17 61.9 1.4 0.0097 16.2 0.0 6.0 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 VDK80437.1 - 3.4e-07 30.0 0.1 6.7e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 LisH Nup160 PF11715.8 VDK80437.1 - 2.6e-06 26.4 2.0 0.066 11.8 0.0 4.1 2 1 1 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 VDK80437.1 - 0.002 16.9 0.9 0.53 9.0 0.0 3.7 3 1 3 6 6 6 1 Nup133 N terminal like ArsA_HSP20 PF17886.1 VDK80438.1 - 0.17 11.4 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 HSP20-like domain found in ArsA COX14 PF14880.6 VDK80447.1 - 0.15 11.9 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Ldl_recept_b PF00058.17 VDK80448.1 - 3.5e-20 72.2 5.0 3.7e-06 27.3 0.0 5.3 5 0 0 5 5 5 3 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 VDK80448.1 - 4.5e-07 30.0 21.7 3.1e-06 27.3 9.8 4.7 5 0 0 5 5 5 2 Low-density lipoprotein receptor domain class A EGF_CA PF07645.15 VDK80448.1 - 4.9e-06 26.7 5.7 4.9e-06 26.7 5.7 4.9 3 1 2 5 5 5 1 Calcium-binding EGF domain FXa_inhibition PF14670.6 VDK80448.1 - 9.8e-05 22.6 6.5 9.8e-05 22.6 6.5 4.1 3 1 1 4 4 4 2 Coagulation Factor Xa inhibitory site Tme5_EGF_like PF09064.10 VDK80448.1 - 0.0072 16.2 7.5 0.0072 16.2 7.5 3.1 2 0 0 2 2 2 1 Thrombomodulin like fifth domain, EGF-like SGL PF08450.12 VDK80448.1 - 0.012 15.2 0.1 0.2 11.2 0.0 2.2 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DUF1642 PF07852.11 VDK80448.1 - 0.024 15.2 0.6 7.2 7.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1642) hEGF PF12661.7 VDK80448.1 - 1 10.1 15.0 1.1 10.0 1.5 4.1 3 0 0 3 3 3 0 Human growth factor-like EGF Ras PF00071.22 VDK80450.1 - 2.9e-63 212.3 0.4 3.3e-63 212.1 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK80450.1 - 7.7e-36 122.9 0.1 1.3e-35 122.2 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK80450.1 - 3.7e-13 49.3 0.0 4.5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK80450.1 - 1.2e-05 25.3 0.0 1.6e-05 24.9 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK80450.1 - 1.7e-05 24.3 0.0 2.1e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 VDK80450.1 - 0.00032 20.3 0.1 0.00068 19.2 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK80450.1 - 0.00084 19.3 1.5 0.34 10.8 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 VDK80450.1 - 0.018 15.5 0.2 0.029 14.7 0.2 1.4 1 1 0 1 1 1 0 AAA ATPase domain Beta-Casp PF10996.8 VDK80450.1 - 0.024 14.9 0.1 0.038 14.3 0.1 1.2 1 0 0 1 1 1 0 Beta-Casp domain B12-binding PF02310.19 VDK80450.1 - 0.041 13.9 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 B12 binding domain MCR_beta PF02241.18 VDK80450.1 - 0.052 13.2 0.2 0.065 12.8 0.2 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain AAA_22 PF13401.6 VDK80450.1 - 0.13 12.5 0.0 0.74 10.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain UQ_con PF00179.26 VDK80451.1 - 5.3e-41 139.5 0.1 6.6e-41 139.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Exog_C PF18026.1 VDK80451.1 - 0.061 13.4 0.2 0.13 12.3 0.2 1.5 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain UEV PF05743.13 VDK80451.1 - 0.073 12.9 0.2 0.16 11.9 0.2 1.5 1 1 0 1 1 1 0 UEV domain Prefoldin PF02996.17 VDK80453.1 - 3.9e-23 81.6 4.3 6.5e-23 80.9 4.3 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 VDK80453.1 - 0.056 13.4 8.3 0.084 12.8 0.5 2.4 1 1 1 2 2 2 0 Prefoldin subunit Osmo_CC PF08946.10 VDK80453.1 - 0.12 12.6 2.1 8.7 6.7 0.0 3.1 2 1 0 2 2 2 0 Osmosensory transporter coiled coil RPEL PF02755.15 VDK80455.1 - 2.6e-15 55.5 8.4 2.1e-07 30.4 4.1 2.9 2 0 0 2 2 2 2 RPEL repeat RecG_wedge PF17191.4 VDK80455.1 - 0.022 14.4 0.8 0.052 13.2 0.2 1.9 2 0 0 2 2 2 0 RecG wedge domain zf-RING_2 PF13639.6 VDK80456.1 - 4.5e-13 49.3 6.0 4.5e-13 49.3 6.0 3.4 3 1 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 VDK80456.1 - 9.9e-09 34.8 3.3 9.9e-09 34.8 3.3 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 VDK80456.1 - 2.3e-08 33.7 4.6 2.3e-08 33.7 4.6 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK80456.1 - 3.5e-08 33.6 5.3 3.5e-08 33.6 5.3 2.8 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 VDK80456.1 - 6.8e-06 25.9 3.3 6.8e-06 25.9 3.3 2.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 VDK80456.1 - 2.5e-05 24.0 4.2 2.5e-05 24.0 4.2 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK80456.1 - 8.1e-05 22.4 4.0 8.1e-05 22.4 4.0 2.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK80456.1 - 0.012 15.7 2.8 0.012 15.7 2.8 2.8 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger SYS1 PF09801.9 VDK80457.1 - 1.5e-33 116.0 10.3 2.1e-33 115.5 10.3 1.2 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network ThiF PF00899.21 VDK80458.1 - 9.1e-49 166.0 0.2 1.4e-48 165.4 0.2 1.3 1 0 0 1 1 1 1 ThiF family 2-Hacid_dh_C PF02826.19 VDK80458.1 - 0.00049 19.5 0.0 0.00089 18.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 VDK80458.1 - 0.003 18.0 0.0 0.008 16.6 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 VDK80458.1 - 0.012 15.8 2.8 0.13 12.5 1.6 2.7 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain PglD_N PF17836.1 VDK80458.1 - 0.017 15.7 0.0 0.039 14.6 0.0 1.6 1 0 0 1 1 1 0 PglD N-terminal domain UDPG_MGDP_dh_N PF03721.14 VDK80458.1 - 0.051 13.2 0.3 0.11 12.0 0.1 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 VDK80458.1 - 0.065 12.5 0.5 0.11 11.7 0.5 1.3 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 VDK80458.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 VDK80458.1 - 0.11 12.8 0.3 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain ApbA PF02558.16 VDK80458.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA BOP1NT PF08145.12 VDK80459.1 - 3.1e-97 325.6 6.5 3.7e-97 325.3 6.5 1.0 1 0 0 1 1 1 1 BOP1NT (NUC169) domain Abhydrolase_1 PF00561.20 VDK80468.1 - 1.7e-08 34.4 0.0 3e-07 30.4 0.0 2.1 1 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK80468.1 - 9.6e-05 21.7 0.1 0.00052 19.4 0.1 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S66 PF02016.15 VDK80468.1 - 0.015 15.4 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain Palm_thioest PF02089.15 VDK80468.1 - 0.046 13.5 0.0 0.064 13.1 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Cutinase PF01083.22 VDK80468.1 - 0.054 13.5 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 Cutinase Trans_coact PF16805.5 VDK80468.1 - 0.13 12.4 0.0 0.62 10.2 0.0 2.1 2 0 0 2 2 2 0 Phage late-transcription coactivator DUF915 PF06028.11 VDK80468.1 - 0.25 10.7 0.0 0.37 10.1 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) SR-25 PF10500.9 VDK80470.1 - 0.76 9.4 5.4 0.86 9.2 5.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CTD_bind PF04818.13 VDK80471.1 - 2.2e-13 50.8 0.1 9.1e-13 48.8 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 VDK80471.1 - 1.7e-06 27.8 0.0 3e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BTAD PF03704.17 VDK80471.1 - 0.011 16.1 0.1 0.18 12.3 0.1 2.3 2 0 0 2 2 2 0 Bacterial transcriptional activator domain HWE_HK PF07536.14 VDK80471.1 - 0.032 14.9 0.2 0.69 10.7 0.2 2.5 2 0 0 2 2 2 0 HWE histidine kinase COMPASS-Shg1 PF05205.12 VDK80471.1 - 0.041 14.6 0.5 0.14 12.9 0.5 1.9 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 Ndr PF03096.14 VDK80472.1 - 1.6e-87 292.8 0.0 6e-82 274.5 0.0 2.0 1 1 0 2 2 2 2 Ndr family Abhydrolase_1 PF00561.20 VDK80472.1 - 0.00044 20.0 0.0 0.00082 19.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK80472.1 - 0.0081 15.4 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF3530 PF12048.8 VDK80472.1 - 0.019 14.4 0.1 0.028 13.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Collagen PF01391.18 VDK80473.1 - 9.9e-25 86.1 95.1 1.1e-09 37.9 32.0 4.4 2 2 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK80473.1 - 5e-08 32.9 0.3 7.9e-08 32.2 0.3 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Myelin_MBP PF01669.17 VDK80473.1 - 0.011 16.4 0.3 0.02 15.5 0.3 1.5 1 0 0 1 1 1 0 Myelin basic protein TSC22 PF01166.18 VDK80481.1 - 9.3e-23 80.3 4.1 1.3e-22 79.9 4.1 1.2 1 0 0 1 1 1 1 TSC-22/dip/bun family Shugoshin_N PF07558.11 VDK80481.1 - 0.002 17.9 0.2 0.0037 17.1 0.2 1.4 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.15 VDK80481.1 - 0.11 12.6 0.2 0.11 12.6 0.2 2.0 2 0 0 2 2 2 0 Basic region leucine zipper IER PF05760.12 VDK80482.1 - 3.4e-09 37.5 0.7 1e-07 32.6 0.0 2.7 2 1 1 3 3 3 1 Immediate early response protein (IER) B277 PF17623.2 VDK80485.1 - 0.058 12.5 1.2 0.13 11.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF1759 PF03564.15 VDK80486.1 - 2.1e-06 27.7 0.0 2.8e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) RasGAP PF00616.19 VDK80487.1 - 5.9e-19 68.6 8.4 1.1e-13 51.4 0.0 3.4 2 2 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 VDK80487.1 - 1.1e-09 38.7 3.6 2e-09 37.9 0.1 3.0 4 0 0 4 4 4 1 PH domain PH_6 PF15406.6 VDK80487.1 - 0.00055 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CC2D2AN-C2 PF15625.6 VDK80493.1 - 4.4e-12 46.1 0.0 1.1e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain C2 PF00168.30 VDK80493.1 - 1.9e-07 31.3 0.1 2.8e-06 27.5 0.0 2.8 3 0 0 3 3 3 1 C2 domain EF-G-binding_N PF07299.11 VDK80493.1 - 0.14 12.7 1.5 2.8 8.5 0.0 3.0 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal Peptidase_S8 PF00082.22 VDK80494.1 - 3.1e-33 115.3 8.4 3.6e-22 79.0 1.1 2.4 2 1 1 3 3 3 2 Subtilase family S8_pro-domain PF16470.5 VDK80494.1 - 2.3e-17 63.5 2.1 4.2e-17 62.7 2.1 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain P_proprotein PF01483.20 VDK80494.1 - 2.6e-13 49.8 0.0 7.6e-13 48.3 0.0 1.8 1 0 0 1 1 1 1 Proprotein convertase P-domain Peptidase_S8_N PF16361.5 VDK80494.1 - 0.11 13.0 1.9 0.19 12.2 1.9 1.4 1 0 0 1 1 1 0 N-terminal of Subtilase family P3A PF08727.11 VDK80494.1 - 0.14 11.6 0.0 0.28 10.6 0.0 1.5 1 0 0 1 1 1 0 Poliovirus 3A protein like Apis_Csd PF11671.8 VDK80494.1 - 5.6 7.0 6.9 9.4 6.2 6.4 1.5 1 1 0 1 1 1 0 Complementary sex determiner protein CSD PF00313.22 VDK80495.1 - 1.9e-26 91.7 0.3 6.2e-26 90.0 0.0 1.9 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 VDK80495.1 - 5.6e-05 22.7 0.1 0.00012 21.7 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease B OB domain zf-CCHC PF00098.23 VDK80495.1 - 2.6 8.3 13.7 0.58 10.3 1.0 2.8 2 1 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 VDK80495.1 - 9.8 6.1 9.4 1.6 8.7 0.7 2.3 2 0 0 2 2 2 0 Zinc knuckle WD40 PF00400.32 VDK80496.1 - 8.4e-20 70.8 3.3 5.6e-06 27.0 0.0 6.8 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK80496.1 - 3.2e-19 69.0 0.0 0.0093 16.2 0.0 6.2 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 VDK80496.1 - 0.0048 16.8 0.0 19 5.4 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 VDK80496.1 - 0.0057 16.0 0.0 0.63 9.3 0.0 2.6 3 0 0 3 3 3 1 WD40-like domain Lactonase PF10282.9 VDK80496.1 - 0.0089 15.3 0.0 1.3 8.2 0.0 2.8 1 1 2 3 3 3 1 Lactonase, 7-bladed beta-propeller IKI3 PF04762.12 VDK80496.1 - 0.043 11.8 0.0 0.28 9.1 0.0 2.1 1 1 0 1 1 1 0 IKI3 family Cytochrom_D1 PF02239.16 VDK80496.1 - 0.056 12.0 0.0 11 4.5 0.0 2.4 1 1 0 2 2 2 0 Cytochrome D1 heme domain Frtz PF11768.8 VDK80496.1 - 0.062 11.6 0.0 4.2 5.6 0.0 2.5 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Ctr PF04145.15 VDK80497.1 - 0.003 18.2 0.3 0.003 18.2 0.3 1.2 1 0 0 1 1 1 1 Ctr copper transporter family TRAM_LAG1_CLN8 PF03798.16 VDK80498.1 - 1.1e-23 84.1 20.8 1.1e-23 84.1 20.8 2.7 3 0 0 3 3 3 1 TLC domain DUF2448 PF10476.9 VDK80498.1 - 0.19 11.6 2.8 0.39 10.5 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function C-terminus (DUF2448) COX5B PF01215.19 VDK80499.1 - 5.6e-08 32.5 0.0 7.5e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Peptidase_M28 PF04389.17 VDK80500.1 - 2.6e-17 63.2 0.0 4e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 VDK80500.1 - 2.2e-09 37.1 0.1 4.1e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 Nicastrin OST-HTH PF12872.7 VDK80501.1 - 5e-11 42.3 2.0 1.3e-06 28.1 0.0 3.7 3 0 0 3 3 3 3 OST-HTH/LOTUS domain TUDOR PF00567.24 VDK80501.1 - 0.00021 21.3 0.5 0.0016 18.5 0.6 2.4 1 1 1 2 2 2 1 Tudor domain BRCT_2 PF16589.5 VDK80501.1 - 0.043 14.2 0.1 10 6.6 0.0 2.9 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain FARP PF01581.16 VDK80502.1 - 0.0049 17.1 7.0 21 6.2 0.1 4.3 5 0 0 5 5 5 3 FMRFamide related peptide family HAT_KAT11 PF08214.11 VDK80504.1 - 5.1e-56 190.5 2.1 1.6e-55 188.8 2.1 1.9 1 1 0 1 1 1 1 Histone acetylation protein KIX PF02172.16 VDK80504.1 - 4.5e-34 116.6 0.8 1e-33 115.4 0.8 1.6 1 0 0 1 1 1 1 KIX domain zf-TAZ PF02135.16 VDK80504.1 - 1.9e-25 89.1 51.3 1.5e-18 67.0 13.1 4.3 5 0 0 5 5 5 2 TAZ zinc finger DUF902 PF06001.13 VDK80504.1 - 1.5e-18 67.0 5.3 1.5e-18 67.0 5.3 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF902) Bromodomain PF00439.25 VDK80504.1 - 3.4e-18 65.5 0.2 3.4e-18 65.5 0.2 2.4 2 0 0 2 2 2 1 Bromodomain ZZ PF00569.17 VDK80504.1 - 1.2e-08 34.6 7.9 1.2e-08 34.6 7.9 3.7 4 0 0 4 4 4 1 Zinc finger, ZZ type KIX_2 PF16987.5 VDK80504.1 - 1.5e-05 24.9 0.2 7.7e-05 22.6 0.2 2.3 1 0 0 1 1 1 1 KIX domain ABC_tran PF00005.27 VDK80505.1 - 2.5e-48 164.1 0.0 2.1e-23 83.3 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 VDK80505.1 - 1.4e-21 77.6 0.4 0.00034 20.5 0.3 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 VDK80505.1 - 6.4e-18 64.6 5.7 6.4e-18 64.6 5.7 3.2 3 1 0 3 3 2 1 ABC transporter SMC_N PF02463.19 VDK80505.1 - 7.6e-11 41.9 0.2 0.00063 19.2 0.1 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 VDK80505.1 - 1.6e-08 34.1 0.1 0.0077 15.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 VDK80505.1 - 1.2e-07 31.8 0.9 0.012 15.3 0.0 3.6 3 1 1 4 4 4 2 AAA ATPase domain AAA_23 PF13476.6 VDK80505.1 - 1.2e-05 25.9 8.3 0.014 15.9 0.1 3.4 4 0 0 4 4 3 2 AAA domain AAA_22 PF13401.6 VDK80505.1 - 1.4e-05 25.4 0.0 0.54 10.5 0.0 3.5 3 1 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 VDK80505.1 - 1.5e-05 25.0 0.2 0.21 11.7 0.0 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase NB-ARC PF00931.22 VDK80505.1 - 1.6e-05 24.2 0.0 0.015 14.5 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain AAA_18 PF13238.6 VDK80505.1 - 3.5e-05 24.3 0.0 0.35 11.4 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_28 PF13521.6 VDK80505.1 - 4.2e-05 23.9 0.0 0.33 11.2 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 VDK80505.1 - 6e-05 23.5 0.0 0.16 12.3 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 VDK80505.1 - 9.4e-05 22.6 0.2 0.71 10.0 0.0 3.4 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 VDK80505.1 - 0.00016 21.6 0.0 0.064 13.2 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase NACHT PF05729.12 VDK80505.1 - 0.00048 20.1 0.1 1 9.3 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_27 PF13514.6 VDK80505.1 - 0.00068 19.3 0.4 1.8 8.1 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 VDK80505.1 - 0.003 17.3 0.0 1.3 8.7 0.0 2.9 3 1 0 3 3 2 1 AAA domain AAA_24 PF13479.6 VDK80505.1 - 0.0033 17.2 0.0 0.75 9.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 VDK80505.1 - 0.0042 17.2 0.5 1.2 9.1 0.0 3.1 3 1 0 3 3 2 1 Dynamin family AAA_14 PF13173.6 VDK80505.1 - 0.0043 17.1 0.0 2.7 8.0 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_17 PF13207.6 VDK80505.1 - 0.0082 16.6 0.1 2.3 8.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 VDK80505.1 - 0.0087 16.4 0.0 1.8 9.0 0.0 2.7 2 0 0 2 2 2 1 RNA helicase AAA PF00004.29 VDK80505.1 - 0.012 16.1 0.0 3.5 8.1 0.0 3.1 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 VDK80505.1 - 0.013 15.1 0.1 2.3 7.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 VDK80505.1 - 0.015 15.4 0.3 4.9 7.2 0.0 2.9 3 0 0 3 3 2 0 Helicase HerA, central domain MukB PF04310.12 VDK80505.1 - 0.016 15.0 0.3 6.5 6.5 0.0 2.9 3 0 0 3 3 3 0 MukB N-terminal PduV-EutP PF10662.9 VDK80505.1 - 0.021 14.6 0.0 9.6 6.0 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_13 PF13166.6 VDK80505.1 - 0.029 13.1 0.7 11 4.5 0.0 3.5 4 0 0 4 4 4 0 AAA domain PhetRS_B1 PF18262.1 VDK80505.1 - 0.031 14.5 0.1 0.18 12.0 0.0 2.4 2 1 0 2 2 1 0 Phe-tRNA synthetase beta subunit B1 domain cobW PF02492.19 VDK80505.1 - 0.033 13.8 0.0 8.3 6.0 0.1 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_5 PF07728.14 VDK80505.1 - 0.042 13.9 0.1 11 6.0 0.1 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Roc PF08477.13 VDK80505.1 - 0.047 13.9 0.0 8.3 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GrpE PF01025.19 VDK80505.1 - 0.051 13.2 0.4 0.051 13.2 0.4 2.2 3 0 0 3 3 2 0 GrpE MT PF12777.7 VDK80505.1 - 0.078 12.0 2.4 0.1 11.6 0.5 1.8 2 0 0 2 2 2 0 Microtubule-binding stalk of dynein motor KapB PF08810.10 VDK80505.1 - 0.09 13.0 0.3 0.33 11.1 0.0 2.2 2 0 0 2 2 1 0 Kinase associated protein B AAA_7 PF12775.7 VDK80505.1 - 0.091 12.3 0.0 13 5.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 VDK80505.1 - 0.096 12.0 0.0 7.3 5.9 0.0 2.6 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 VDK80505.1 - 0.11 12.3 0.0 11 5.7 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF3584 PF12128.8 VDK80505.1 - 0.18 9.3 5.3 1.2 6.6 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) MeaB PF03308.16 VDK80505.1 - 0.28 10.1 1.9 4.4 6.2 0.0 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Mito_carr PF00153.27 VDK80506.1 - 3.2e-67 222.5 4.6 2e-24 85.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Antimicrobial20 PF08256.11 VDK80506.1 - 0.5 11.0 5.9 90 4.1 0.1 4.7 4 0 0 4 4 4 0 Aurein-like antibiotic peptide Pkinase PF00069.25 VDK80507.1 - 1.1e-71 241.3 0.0 1.2e-71 241.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80507.1 - 3.2e-34 118.4 0.0 4e-34 118.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK80507.1 - 0.00021 20.4 0.1 0.0018 17.3 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 VDK80507.1 - 0.13 12.1 0.2 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 VDK80507.1 - 0.29 10.4 1.1 0.58 9.5 1.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PDGF PF00341.17 VDK80508.1 - 3.3e-08 33.7 5.6 3.3e-08 33.7 5.6 2.2 2 1 0 2 2 2 1 PDGF/VEGF domain CXCXC PF03128.14 VDK80508.1 - 0.04 14.3 5.0 0.04 14.3 5.0 4.8 5 0 0 5 5 5 0 CXCXC repeat PEHE PF15275.6 VDK80534.1 - 0.013 16.2 3.6 0.013 16.2 3.6 2.2 2 0 0 2 2 2 0 PEHE domain Transmemb_17 PF09799.9 VDK80535.1 - 1.3e-17 64.3 8.8 1.4e-17 64.2 7.9 1.4 1 1 0 1 1 1 1 Predicted membrane protein PROCN PF08083.11 VDK80537.1 - 4.8e-233 773.2 7.7 4.8e-233 773.2 7.7 2.2 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 VDK80537.1 - 3.5e-127 422.7 1.1 6.1e-127 421.9 1.1 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 VDK80537.1 - 2.2e-89 297.4 2.2 5.3e-89 296.2 2.2 1.7 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 VDK80537.1 - 2.2e-88 293.9 6.9 5.1e-88 292.7 6.2 2.1 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 VDK80537.1 - 1.4e-72 242.1 0.1 2.8e-72 241.1 0.1 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 VDK80537.1 - 1.2e-51 173.8 0.1 2.9e-51 172.5 0.1 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 VDK80537.1 - 4.4e-47 158.4 1.4 6.8e-47 157.8 0.3 2.0 2 0 0 2 2 2 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 VDK80537.1 - 2.4e-07 30.7 0.0 5.9e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CR6_interact PF10147.9 VDK80537.1 - 0.079 12.7 0.0 0.26 11.0 0.0 1.9 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF3337 PF11816.8 VDK80538.1 - 1.8e-40 138.6 0.3 3.4e-40 137.7 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 VDK80538.1 - 1.1e-29 102.0 12.2 5.8e-05 23.8 0.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK80538.1 - 5e-06 26.7 1.6 0.39 11.0 0.1 4.6 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK80538.1 - 0.0091 15.0 0.2 0.24 10.3 0.0 2.3 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 VDK80538.1 - 0.01 14.5 4.3 0.36 9.4 0.4 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 WD40_like PF17005.5 VDK80538.1 - 0.079 12.3 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 WD40-like domain RAWUL PF16207.5 VDK80538.1 - 0.18 12.5 0.1 0.41 11.4 0.1 1.7 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like PB1 PF00564.24 VDK80541.1 - 1.2e-05 25.1 0.0 2.2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 PB1 domain SL4P PF17618.2 VDK80541.1 - 0.00055 19.9 0.1 0.00098 19.1 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized Strongylid L4 protein Astacin PF01400.24 VDK80550.1 - 3.8e-60 202.8 1.5 5.7e-60 202.2 1.5 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 VDK80550.1 - 0.00061 20.1 1.4 0.0016 18.8 0.1 2.2 2 0 0 2 2 2 1 CUB domain Reprolysin_5 PF13688.6 VDK80550.1 - 0.0049 17.1 0.1 0.0083 16.3 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 VDK80550.1 - 0.019 14.8 4.8 0.19 11.5 1.8 2.3 1 1 1 2 2 2 0 Matrixin Reprolysin_2 PF13574.6 VDK80550.1 - 0.023 14.6 0.7 0.063 13.2 0.4 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 VDK80550.1 - 0.023 14.3 0.3 0.049 13.3 0.1 1.7 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 VDK80550.1 - 0.13 11.8 2.0 0.24 11.0 2.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase CAMSAP_CKK PF08683.11 VDK80551.1 - 1.6e-40 138.0 0.0 3.3e-40 136.9 0.0 1.6 1 0 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH PF11971.8 VDK80551.1 - 6.4e-10 38.7 0.1 3.3e-07 30.1 0.1 2.6 1 1 1 2 2 2 2 CAMSAP CH domain FAM199X PF15814.5 VDK80551.1 - 0.031 13.3 5.7 0.088 11.9 5.7 1.7 1 0 0 1 1 1 0 Protein family FAM199X EMP24_GP25L PF01105.24 VDK80551.1 - 2.7 7.9 4.9 7.8 6.4 4.9 1.7 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Pkinase PF00069.25 VDK80553.1 - 1.7e-27 96.5 0.0 2e-27 96.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80553.1 - 9.6e-20 70.9 0.0 1.1e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK80553.1 - 0.01 15.2 0.0 0.021 14.2 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 VDK80553.1 - 0.18 12.0 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 ABC1 family DUF1768 PF08719.11 VDK80554.1 - 4.6e-24 85.5 0.9 7e-24 84.9 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) CortBP2 PF09727.9 VDK80554.1 - 0.0019 18.2 0.3 0.0033 17.3 0.3 1.3 1 0 0 1 1 1 1 Cortactin-binding protein-2 BRE1 PF08647.11 VDK80554.1 - 0.025 14.6 3.1 0.079 13.0 3.1 1.8 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase XhlA PF10779.9 VDK80554.1 - 0.031 14.5 1.8 0.031 14.5 1.8 2.3 3 0 0 3 3 3 0 Haemolysin XhlA HMMR_C PF15908.5 VDK80554.1 - 0.45 10.8 4.9 0.26 11.5 2.5 1.8 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal PHO4 PF01384.20 VDK80559.1 - 2.6e-122 408.1 18.6 3.5e-122 407.7 18.6 1.2 1 0 0 1 1 1 1 Phosphate transporter family HTH_IclR PF09339.10 VDK80559.1 - 0.36 10.7 2.0 0.99 9.3 0.1 2.4 2 0 0 2 2 2 0 IclR helix-turn-helix domain PHO4 PF01384.20 VDK80560.1 - 3.9e-121 404.2 19.9 5.7e-121 403.7 19.9 1.2 1 0 0 1 1 1 1 Phosphate transporter family DUF5600 PF18150.1 VDK80563.1 - 1.5e-46 157.4 1.4 1.5e-46 157.4 1.4 1.8 2 0 0 2 2 1 1 Domain of unknown function (DUF5600) EHD_N PF16880.5 VDK80563.1 - 1.2e-17 63.5 3.4 2.6e-17 62.4 3.4 1.6 1 0 0 1 1 1 1 N-terminal EH-domain containing protein EF-hand_4 PF12763.7 VDK80563.1 - 2.3e-17 62.8 0.0 1.2e-16 60.5 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Dynamin_N PF00350.23 VDK80563.1 - 3.4e-14 53.2 0.0 3e-13 50.2 0.0 2.4 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 VDK80563.1 - 1.6e-08 34.6 0.0 5.3e-08 32.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase EF-hand_1 PF00036.32 VDK80563.1 - 0.001 18.5 0.5 0.0072 15.8 0.1 2.8 2 0 0 2 2 2 1 EF hand Roc PF08477.13 VDK80563.1 - 0.013 15.8 0.0 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 VDK80563.1 - 0.017 15.1 0.0 2.6 8.0 0.0 3.0 2 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 VDK80563.1 - 0.018 15.5 0.1 0.77 10.1 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain EF-hand_6 PF13405.6 VDK80563.1 - 0.038 13.9 0.3 0.38 10.8 0.1 2.8 3 0 0 3 3 3 0 EF-hand domain AAA_28 PF13521.6 VDK80563.1 - 0.045 14.0 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain EF-hand_8 PF13833.6 VDK80563.1 - 0.12 12.3 4.4 3.1 7.7 0.1 2.9 3 0 0 3 3 3 0 EF-hand domain pair cobW PF02492.19 VDK80563.1 - 0.18 11.4 0.0 15 5.1 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 VDK80563.1 - 0.9 10.0 3.2 28 5.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain Innexin PF00876.18 VDK80565.1 - 4.5e-109 364.9 14.4 5.5e-109 364.7 14.4 1.1 1 0 0 1 1 1 1 Innexin Aminotran_1_2 PF00155.21 VDK80566.1 - 1.5e-07 30.9 0.0 2.2e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Gp_dh_N PF00044.24 VDK80573.1 - 1.8e-24 86.0 0.2 3.6e-24 85.0 0.2 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DUF148 PF02520.17 VDK80573.1 - 1.3e-06 28.4 1.1 1.3e-05 25.3 0.7 2.3 2 1 0 2 2 2 1 Domain of unknown function DUF148 Metal_resist PF13801.6 VDK80573.1 - 0.012 15.9 0.2 4.9 7.3 0.5 3.1 2 2 1 3 3 3 0 Heavy-metal resistance 2-Hacid_dh_C PF02826.19 VDK80573.1 - 0.043 13.2 0.0 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DapB_N PF01113.20 VDK80573.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus IGPS PF00218.21 VDK80573.1 - 0.068 12.3 0.3 0.1 11.8 0.3 1.2 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase EKAL PF17986.1 VDK80573.1 - 0.094 12.8 3.5 0.23 11.5 1.4 2.4 2 0 0 2 2 2 0 EMP3-KAHRP-like N-terminal domain HD_3 PF13023.6 VDK80573.1 - 0.46 10.4 3.6 30 4.5 2.1 2.8 2 1 1 3 3 3 0 HD domain N6-adenineMlase PF10237.9 VDK80574.1 - 1.9e-20 73.3 0.1 3.4e-20 72.5 0.1 1.5 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase CD24 PF14984.6 VDK80574.1 - 0.39 11.0 6.1 0.85 9.9 6.1 1.5 1 0 0 1 1 1 0 CD24 protein Sec6 PF06046.13 VDK80575.1 - 1.1e-94 317.9 12.3 6.8e-66 222.8 3.3 2.5 3 0 0 3 3 3 2 Exocyst complex component Sec6 DUF1786 PF08735.10 VDK80575.1 - 0.031 13.6 0.4 0.054 12.8 0.4 1.3 1 0 0 1 1 1 0 Putative pyruvate format-lyase activating enzyme (DUF1786) YabA PF06156.13 VDK80575.1 - 8.8 7.0 9.0 22 5.8 0.0 3.9 2 1 1 3 3 3 0 Initiation control protein YabA Nup54 PF13874.6 VDK80577.1 - 8.1e-05 22.8 0.3 0.00023 21.3 0.3 1.7 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 DUF3939 PF13075.6 VDK80577.1 - 0.03 14.4 0.1 0.085 12.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3939) Syntaxin_2 PF14523.6 VDK80577.1 - 2.1 8.7 6.2 13 6.2 1.9 3.0 1 1 1 2 2 2 0 Syntaxin-like protein Adaptin_N PF01602.20 VDK80579.1 - 1.5e-130 436.2 5.0 2e-130 435.8 5.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 VDK80579.1 - 1.7e-51 174.4 0.2 4.2e-51 173.1 0.2 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 VDK80579.1 - 1.5e-36 125.0 0.0 3e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 VDK80579.1 - 1.3e-18 67.1 4.3 1.6e-08 34.8 0.1 6.1 4 1 0 5 5 5 3 HEAT repeats Cnd1 PF12717.7 VDK80579.1 - 1.3e-14 54.5 6.5 1.3e-06 28.5 0.1 4.1 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 VDK80579.1 - 4.7e-05 23.8 2.3 0.0021 18.5 0.2 3.8 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 VDK80579.1 - 0.014 15.6 13.4 20 5.8 0.0 6.7 7 0 0 7 7 7 0 HEAT repeat Nipped-B_C PF12830.7 VDK80579.1 - 0.016 15.2 0.1 5.2 7.0 0.0 3.0 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus HEAT_PBS PF03130.16 VDK80579.1 - 0.058 14.1 1.0 0.57 11.0 0.2 3.3 3 0 0 3 3 2 0 PBS lyase HEAT-like repeat Vitellogenin_N PF01347.22 VDK80579.1 - 0.19 10.1 1.4 1.5 7.1 0.2 2.7 3 1 0 3 3 3 0 Lipoprotein amino terminal region UNC45-central PF11701.8 VDK80579.1 - 0.42 10.6 5.3 15 5.5 0.3 4.2 4 1 1 5 5 5 0 Myosin-binding striated muscle assembly central Trypsin PF00089.26 VDK80580.1 - 1e-12 48.4 0.2 4.7e-10 39.6 0.0 2.6 2 1 0 2 2 2 2 Trypsin DUF316 PF03761.15 VDK80580.1 - 1.2e-10 41.5 0.0 1.2e-08 34.9 0.0 2.1 2 0 0 2 2 2 2 Chymotrypsin family Peptidase-S1 Trypsin_2 PF13365.6 VDK80580.1 - 0.0027 18.6 0.0 0.0044 17.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain ARD PF03079.14 VDK80582.1 - 6.1e-37 127.2 0.1 6.6e-37 127.1 0.1 1.0 1 0 0 1 1 1 1 ARD/ARD' family EutQ PF06249.12 VDK80582.1 - 0.0039 17.0 0.1 0.0051 16.6 0.1 1.1 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_2 PF07883.11 VDK80582.1 - 0.01 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Cupin_1 PF00190.22 VDK80582.1 - 0.12 12.0 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Cupin Pkinase PF00069.25 VDK80591.1 - 1.3e-26 93.5 0.0 1.8e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80591.1 - 7.3e-13 48.4 0.0 9.3e-13 48.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK80591.1 - 0.0067 15.8 0.1 0.015 14.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PDZ_2 PF13180.6 VDK80592.1 - 0.00059 20.1 0.0 0.0017 18.7 0.0 1.7 1 0 0 1 1 1 1 PDZ domain MPC PF03650.13 VDK80593.1 - 4.1e-35 120.2 0.2 4.8e-35 120.0 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Rota_VP2 PF05087.12 VDK80593.1 - 0.015 13.5 0.0 0.017 13.3 0.0 1.0 1 0 0 1 1 1 0 Rotavirus VP2 protein Pkinase PF00069.25 VDK80595.1 - 2.8e-73 246.5 0.0 4.2e-73 246.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80595.1 - 1e-34 120.0 0.0 1.6e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK80595.1 - 8.3e-08 31.6 0.0 8.3e-08 31.6 0.0 2.0 3 0 0 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 VDK80595.1 - 2.9e-05 23.5 0.1 9.6e-05 21.8 0.1 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK80595.1 - 0.007 15.7 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 VDK80595.1 - 0.1 12.2 0.1 0.29 10.7 0.1 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 VDK80595.1 - 0.15 11.9 0.6 6.5 6.6 0.0 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family IFP_35_N PF07334.13 VDK80595.1 - 2.6 8.2 5.9 0.34 11.0 0.4 2.4 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Es2 PF09751.9 VDK80596.1 - 4.7e-73 247.4 8.0 4.7e-73 247.4 8.0 1.9 2 0 0 2 2 2 1 Nuclear protein Es2 Mst1_SARAH PF11629.8 VDK80596.1 - 0.27 11.3 1.7 14 5.8 0.2 2.6 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 Bestrophin PF01062.21 VDK80597.1 - 3.6e-56 190.7 3.9 2.7e-54 184.6 3.9 2.0 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel DBR1 PF05011.13 VDK80597.1 - 0.034 14.6 0.0 0.048 14.1 0.0 1.2 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain zf-C3Hc3H PF13891.6 VDK80598.1 - 3.5e-08 33.7 1.6 9.2e-07 29.1 1.0 2.4 2 0 0 2 2 2 1 Potential DNA-binding domain VasI PF11319.8 VDK80598.1 - 0.28 10.8 2.5 0.53 9.9 2.5 1.4 1 0 0 1 1 1 0 Type VI secretion system VasI, EvfG, VC_A0118 Dynactin_p62 PF05502.13 VDK80600.1 - 1.8e-26 93.0 22.5 2.3e-15 56.3 18.8 3.0 1 1 0 2 2 2 2 Dynactin p62 family UFC1 PF08694.11 VDK80601.1 - 1.4e-82 274.9 0.0 1.6e-82 274.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 VDK80601.1 - 0.033 13.8 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme SLATT_5 PF18160.1 VDK80601.1 - 0.05 12.9 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 RWD PF05773.22 VDK80601.1 - 0.053 13.8 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain Lig_chan PF00060.26 VDK80604.1 - 2.6e-46 157.1 0.1 3.9e-46 156.6 0.1 1.2 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 VDK80604.1 - 1.1e-07 31.6 0.0 2.1e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Ion_trans_2 PF07885.16 VDK80604.1 - 0.83 9.7 6.6 0.64 10.0 1.3 2.4 2 0 0 2 2 2 0 Ion channel Runt PF00853.19 VDK80611.1 - 2e-56 189.1 0.0 2.7e-56 188.7 0.0 1.2 1 0 0 1 1 1 1 Runt domain RRM_7 PF16367.5 VDK80613.1 - 1e-30 105.7 0.1 2.5e-29 101.2 0.0 2.7 2 0 0 2 2 2 1 RNA recognition motif CEBP_ZZ PF16366.5 VDK80613.1 - 2.8e-21 75.5 9.7 2.8e-21 75.5 9.7 2.2 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 VDK80613.1 - 2.4e-06 27.3 0.0 0.0026 17.5 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RB_A PF01858.17 VDK80616.1 - 3.1e-47 161.0 1.8 8.7e-47 159.5 1.4 2.0 2 0 0 2 2 2 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 VDK80616.1 - 2.9e-44 150.3 0.4 3.9e-43 146.6 0.1 2.5 2 0 0 2 2 2 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 VDK80616.1 - 3.2e-26 91.5 4.7 4.3e-26 91.1 0.6 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3452) TFIIB PF00382.19 VDK80616.1 - 0.019 15.0 0.0 0.65 10.1 0.0 2.9 3 0 0 3 3 3 0 Transcription factor TFIIB repeat DUF1717 PF05414.11 VDK80616.1 - 0.23 11.9 1.1 0.48 10.9 0.5 1.9 2 0 0 2 2 2 0 Viral domain of unknown function (DUF1717) Cation_efflux PF01545.21 VDK80617.1 - 3.6e-48 164.0 14.6 3.6e-48 164.0 14.6 2.9 2 1 1 3 3 3 1 Cation efflux family DUF3188 PF11384.8 VDK80617.1 - 1.2 8.9 5.6 11 5.8 0.2 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) Neur_chan_LBD PF02931.23 VDK80618.1 - 9.2e-16 57.9 0.5 1.6e-15 57.1 0.5 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK80618.1 - 0.0058 16.7 6.8 0.0058 16.7 6.8 2.3 1 1 1 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Sharpin_PH PF16764.5 VDK80618.1 - 0.11 12.3 0.1 0.72 9.6 0.1 2.1 1 1 0 1 1 1 0 Sharpin PH domain Acyltransferase PF01553.21 VDK80626.1 - 1.8e-12 47.1 0.0 2.8e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Pkinase PF00069.25 VDK80628.1 - 2.2e-42 145.3 0.0 2.3e-27 96.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80628.1 - 4.6e-20 72.0 0.0 4e-16 59.1 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK80628.1 - 1.3e-05 24.2 0.0 1.7e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK80628.1 - 0.00014 21.9 0.1 0.015 15.2 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 VDK80628.1 - 0.0033 16.8 0.1 0.0062 15.9 0.1 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 VDK80628.1 - 0.0087 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.6 VDK80628.1 - 0.011 15.1 0.0 3.3 7.0 0.0 2.2 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 VDK80628.1 - 0.02 14.5 0.0 0.038 13.6 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 LTP_2 PF14368.6 VDK80628.1 - 0.033 14.3 0.1 0.063 13.4 0.1 1.4 1 0 0 1 1 1 0 Probable lipid transfer zf-Paramyx-P PF13008.7 VDK80628.1 - 7.1 6.2 11.4 0.41 10.1 5.6 2.0 2 0 0 2 2 2 0 Zinc-binding domain of Paramyxoviridae V protein Ribosomal_L28e PF01778.17 VDK80630.1 - 2.2e-27 96.1 1.0 2.7e-27 95.8 1.0 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family Tctex-1 PF03645.13 VDK80632.1 - 2.3e-10 40.6 0.0 3.1e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Band_7 PF01145.25 VDK80632.1 - 0.044 13.8 0.0 0.049 13.6 0.0 1.1 1 0 0 1 1 1 0 SPFH domain / Band 7 family DUF3772 PF12607.8 VDK80632.1 - 0.13 12.0 0.1 0.22 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) DUF148 PF02520.17 VDK80634.1 - 1.9e-07 31.1 8.2 3.6e-07 30.2 8.2 1.4 1 0 0 1 1 1 1 Domain of unknown function DUF148 DUF2681 PF10883.8 VDK80634.1 - 2.9 8.3 9.6 1.4 9.4 5.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) AAA PF00004.29 VDK80636.1 - 1e-05 26.0 0.0 2.8e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 VDK80636.1 - 0.00059 19.7 0.0 0.0028 17.5 0.0 2.2 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_16 PF13191.6 VDK80636.1 - 0.025 14.9 0.1 0.17 12.3 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_assoc_2 PF16193.5 VDK80636.1 - 0.033 14.5 0.4 0.97 9.8 0.0 3.2 3 0 0 3 3 3 0 AAA C-terminal domain DZF PF07528.14 VDK80636.1 - 0.057 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 DZF domain DUF4158 PF13700.6 VDK80636.1 - 0.064 13.1 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) ABC_tran PF00005.27 VDK80636.1 - 0.069 13.7 0.1 0.61 10.6 0.0 2.6 2 0 0 2 2 2 0 ABC transporter DNA_pol3_delta PF06144.13 VDK80636.1 - 0.088 12.6 0.0 0.38 10.5 0.0 2.1 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_22 PF13401.6 VDK80636.1 - 0.13 12.6 0.1 9.9 6.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain Proteasome PF00227.26 VDK80637.1 - 4.6e-44 150.2 0.2 6.4e-44 149.7 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 VDK80637.1 - 5.4e-14 51.6 0.1 1.2e-13 50.4 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF5018 PF16410.5 VDK80637.1 - 5e-05 22.2 0.1 9.2e-05 21.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5018) DUF148 PF02520.17 VDK80640.1 - 0.0087 16.2 0.1 0.012 15.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF148 Ribonuc_2-5A PF06479.12 VDK80640.1 - 0.029 14.5 0.5 0.043 14.0 0.5 1.5 1 1 0 1 1 1 0 Ribonuclease 2-5A Cas_Cas6 PF01881.16 VDK80640.1 - 0.17 12.4 2.3 0.59 10.7 0.6 2.1 1 1 1 2 2 2 0 CRISPR associated protein Cas6 zf-C2H2 PF00096.26 VDK80641.1 - 0.0048 17.3 6.4 0.02 15.3 2.7 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type PBD PF00786.28 VDK80641.1 - 0.019 15.3 0.0 0.045 14.1 0.0 1.5 1 0 0 1 1 1 0 P21-Rho-binding domain XPA_N PF01286.18 VDK80641.1 - 0.054 13.5 0.3 0.054 13.5 0.3 2.6 3 0 0 3 3 3 0 XPA protein N-terminal ZYG-11_interact PF05884.12 VDK80643.1 - 3.1e-25 89.2 15.8 3.3e-25 89.1 15.8 1.0 1 0 0 1 1 1 1 Interactor of ZYG-11 Peptidase_C12 PF01088.21 VDK80644.1 - 5e-68 229.0 0.1 2.1e-67 226.9 0.0 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 VDK80644.1 - 7.9e-19 67.3 2.0 7.9e-19 67.3 2.0 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases Acetyltransf_6 PF13480.7 VDK80644.1 - 0.03 14.5 0.1 0.3 11.3 0.2 2.3 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain PRP38 PF03371.15 VDK80645.1 - 1.8e-23 83.3 0.0 2.5e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 PRP38 family PRP38 PF03371.15 VDK80646.1 - 9e-22 77.8 0.0 1.2e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 PRP38 family Gal-bind_lectin PF00337.22 VDK80647.1 - 3.9e-38 130.0 0.0 2e-31 108.3 0.0 2.0 2 0 0 2 2 2 2 Galactoside-binding lectin Alginate_lyase2 PF08787.11 VDK80647.1 - 0.00083 19.3 0.1 0.032 14.1 0.1 2.1 1 1 1 2 2 2 2 Alginate lyase Ras PF00071.22 VDK80655.1 - 1.4e-07 31.3 0.0 3.5e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Ras family DnaG_DnaB_bind PF08278.11 VDK80655.1 - 0.08 13.5 0.0 0.22 12.1 0.0 1.8 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding RNA_pol_Rpb4 PF03874.16 VDK80658.1 - 5.9e-23 81.5 3.6 7.4e-23 81.2 3.6 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 DUF2757 PF10955.8 VDK80658.1 - 0.017 15.4 0.1 0.032 14.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) HBD PF18534.1 VDK80658.1 - 0.025 14.7 0.5 0.043 13.9 0.5 1.4 1 0 0 1 1 1 0 Helical bundle domain LPD13 PF18825.1 VDK80658.1 - 0.088 12.6 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 13 RNA_pol_Rpb5_C PF01191.19 VDK80658.1 - 0.46 10.4 2.2 0.55 10.1 0.3 1.9 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain ADH_zinc_N PF00107.26 VDK80661.1 - 5.6e-17 61.9 0.0 1.4e-16 60.6 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 VDK80661.1 - 6.9e-14 51.7 0.0 1e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 VDK80661.1 - 1.8e-10 42.0 0.0 3.5e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase MH2 PF03166.14 VDK80663.1 - 1.4e-09 38.5 0.0 3e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 MH2 domain DUF745 PF05335.13 VDK80665.1 - 0.009 15.8 10.3 0.009 15.8 10.3 7.4 5 2 3 10 10 10 1 Protein of unknown function (DUF745) DUF4843 PF16132.5 VDK80665.1 - 0.017 14.7 0.5 0.11 12.1 0.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4843) zf-C2H2_2 PF12756.7 VDK80676.1 - 1.1e-06 28.9 3.0 0.0011 19.2 0.3 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) NEMO PF11577.8 VDK80676.1 - 0.081 13.0 0.7 0.19 11.8 0.7 1.6 1 0 0 1 1 1 0 NF-kappa-B essential modulator NEMO UPF1_Zn_bind PF09416.10 VDK80676.1 - 0.14 12.1 1.4 0.45 10.5 0.5 2.0 2 0 0 2 2 2 0 RNA helicase (UPF2 interacting domain) Telomere_reg-2 PF10193.9 VDK80678.1 - 8.4e-23 80.9 0.1 2.9e-22 79.2 0.1 2.0 1 0 0 1 1 1 1 Telomere length regulation protein SDA1 PF05285.12 VDK80679.1 - 9.5e-59 199.6 36.3 5.4e-57 193.8 26.5 3.1 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 VDK80679.1 - 2.7e-14 53.2 0.0 9.9e-13 48.2 0.0 2.9 2 0 0 2 2 2 1 NUC130/3NT domain HEAT_2 PF13646.6 VDK80679.1 - 0.00033 21.0 0.0 0.12 12.8 0.0 3.4 3 1 1 4 4 4 2 HEAT repeats YL1 PF05764.13 VDK80679.1 - 0.016 15.3 2.1 0.016 15.3 2.1 2.5 2 1 0 2 2 2 0 YL1 nuclear protein Cnd1 PF12717.7 VDK80679.1 - 0.051 13.6 2.9 0.11 12.6 1.2 2.5 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.8 VDK80679.1 - 0.22 11.5 5.4 4.9 7.1 0.1 3.5 4 1 0 4 4 4 0 Myosin-binding striated muscle assembly central AAA PF00004.29 VDK80681.1 - 2.7e-41 141.1 0.0 7.8e-41 139.6 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK80681.1 - 1.1e-10 41.2 1.0 2e-10 40.3 1.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 VDK80681.1 - 3.6e-10 39.6 0.0 7.3e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 VDK80681.1 - 4.7e-06 26.9 0.4 0.004 17.4 0.1 2.7 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.14 VDK80681.1 - 1.3e-05 25.4 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 VDK80681.1 - 6e-05 22.3 0.0 0.00011 21.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 VDK80681.1 - 0.00044 20.8 0.1 0.0018 18.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 VDK80681.1 - 0.00083 19.1 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Prot_ATP_OB_N PF17758.1 VDK80681.1 - 0.00084 18.9 1.0 0.005 16.5 0.0 2.5 3 0 0 3 3 3 1 Proteasomal ATPase OB N-terminal domain AAA_5 PF07728.14 VDK80681.1 - 0.0019 18.2 0.1 0.0093 16.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 VDK80681.1 - 0.0019 18.5 0.4 0.0051 17.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 VDK80681.1 - 0.0042 17.5 0.2 0.074 13.4 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 VDK80681.1 - 0.013 15.6 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 VDK80681.1 - 0.014 15.7 0.0 0.21 12.0 0.0 2.7 3 0 0 3 3 3 0 RNA helicase AAA_3 PF07726.11 VDK80681.1 - 0.023 14.5 0.1 0.066 13.1 0.0 1.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 VDK80681.1 - 0.034 13.9 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_14 PF13173.6 VDK80681.1 - 0.038 14.0 0.0 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 VDK80681.1 - 0.056 12.8 0.1 0.8 9.0 0.0 2.2 1 1 0 2 2 2 0 KaiC AAA_25 PF13481.6 VDK80681.1 - 0.065 12.8 0.5 4.9 6.7 0.2 2.4 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 VDK80681.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Pkinase PF00069.25 VDK80686.1 - 2.1e-53 181.4 0.1 3e-53 180.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK80686.1 - 8.8e-25 87.5 0.1 1.7e-24 86.5 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK80686.1 - 1.1e-07 31.4 0.0 1e-05 25.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 VDK80686.1 - 0.00011 21.8 0.0 0.00038 20.1 0.0 1.9 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.14 VDK80686.1 - 0.0013 18.2 0.1 0.0038 16.6 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK80686.1 - 0.0015 18.5 0.0 0.012 15.6 0.0 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family DUF3704 PF12488.8 VDK80686.1 - 0.027 14.1 0.2 0.056 13.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3704) DUF1840 PF08895.11 VDK80686.1 - 0.14 12.5 1.3 6 7.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Pkinase_fungal PF17667.1 VDK80686.1 - 0.8 8.4 0.0 0.8 8.4 0.0 2.3 3 0 0 3 3 3 0 Fungal protein kinase CSN5_C PF18323.1 VDK80686.1 - 1.1 10.2 5.3 11 7.0 0.4 2.8 3 0 0 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain SbcD_C PF12320.8 VDK80686.1 - 1.2 9.5 4.5 1 9.7 0.6 2.7 3 0 0 3 3 3 0 Type 5 capsule protein repressor C-terminal domain TBPIP PF07106.13 VDK80687.1 - 2.1e-15 56.4 0.1 7.3e-15 54.7 0.1 1.9 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain FlxA PF14282.6 VDK80687.1 - 0.0014 18.6 3.1 0.0014 18.6 3.1 2.2 1 1 1 2 2 2 1 FlxA-like protein Spc7 PF08317.11 VDK80687.1 - 0.0053 15.7 13.3 0.0053 15.7 13.3 1.7 1 1 1 2 2 2 1 Spc7 kinetochore protein ACP_syn_III_C PF08541.10 VDK80687.1 - 0.011 15.9 0.3 4.8 7.4 0.0 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal LZ3wCH PF18517.1 VDK80687.1 - 0.041 14.0 3.6 0.041 14.0 3.6 2.7 2 2 0 2 2 2 0 Leucine zipper with capping helix domain GUCT PF08152.12 VDK80687.1 - 0.057 13.7 0.7 0.25 11.6 0.0 2.2 2 1 0 2 2 2 0 GUCT (NUC152) domain Exonuc_VII_L PF02601.15 VDK80687.1 - 0.072 12.7 4.4 0.096 12.2 4.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DKNYY PF13644.6 VDK80687.1 - 0.11 13.3 4.8 0.17 12.7 4.8 1.3 1 0 0 1 1 1 0 DKNYY family Snapin_Pallidin PF14712.6 VDK80687.1 - 0.58 10.6 7.7 1.5 9.3 0.4 2.7 1 1 1 2 2 2 0 Snapin/Pallidin Nas2_N PF18265.1 VDK80687.1 - 1 9.3 5.0 19 5.3 0.4 3.0 2 1 1 3 3 3 0 Nas2 N_terminal domain GCR1_C PF12550.8 VDK80687.1 - 1.6 9.1 6.3 2.5 8.5 3.9 2.6 2 1 0 2 2 2 0 Transcriptional activator of glycolytic enzymes SlyX PF04102.12 VDK80687.1 - 2.4 8.8 5.5 20 5.9 0.4 3.0 1 1 2 3 3 3 0 SlyX Swi5 PF07061.11 VDK80687.1 - 5.6 7.1 13.7 5.3 7.2 5.6 2.7 1 1 1 2 2 2 0 Swi5 DUF4250 PF14056.6 VDK80687.1 - 6.8 6.7 7.8 4 7.5 0.1 3.8 4 1 0 4 4 4 0 Domain of unknown function (DUF4250) ANAPC10 PF03256.16 VDK80688.1 - 1.5e-56 190.9 0.1 1.9e-56 190.6 0.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 VDK80688.1 - 0.0029 17.7 0.1 0.0066 16.6 0.1 1.6 1 0 0 1 1 1 1 F5/8 type C domain Chitin_bind_1 PF00187.19 VDK80695.1 - 7.8 7.1 11.4 11 6.6 0.9 2.4 2 0 0 2 2 2 0 Chitin recognition protein ubiquitin PF00240.23 VDK80696.1 - 6.3e-32 109.1 0.7 9.5e-32 108.6 0.2 1.5 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 VDK80696.1 - 7.1e-26 90.1 4.2 7.1e-26 90.1 4.2 1.9 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 VDK80696.1 - 4e-13 49.0 0.2 4e-13 49.0 0.2 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 VDK80696.1 - 9.5e-06 26.0 0.6 6.4e-05 23.3 0.1 2.4 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 VDK80696.1 - 0.00053 20.1 0.9 0.0014 18.7 0.9 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 VDK80696.1 - 0.0052 17.3 0.5 0.0079 16.7 0.5 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Zn_ribbon_SprT PF17283.2 VDK80696.1 - 0.0054 16.6 0.5 0.013 15.4 0.5 1.7 1 0 0 1 1 1 1 SprT-like zinc ribbon domain TBK1_ULD PF18396.1 VDK80696.1 - 0.0062 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 VDK80696.1 - 0.0096 16.3 1.0 0.019 15.3 0.0 1.9 1 1 1 2 2 2 1 Ubiquitin-like domain IBR PF01485.21 VDK80696.1 - 0.036 14.3 1.1 0.076 13.3 1.1 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-CDGSH PF09360.10 VDK80697.1 - 3.2e-17 62.5 1.6 9.3e-10 38.6 0.3 2.3 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type IQ PF00612.27 VDK80701.1 - 1.8e-27 92.5 48.5 1.1e-05 24.8 1.6 7.9 7 0 0 7 7 7 7 IQ calmodulin-binding motif CH PF00307.31 VDK80701.1 - 8.7e-06 25.9 0.1 0.00024 21.3 0.0 3.0 2 0 0 2 2 2 1 Calponin homology (CH) domain DUF1911 PF08929.10 VDK80701.1 - 1.2 9.9 3.3 11 6.8 0.1 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1911) PG_binding_3 PF09374.10 VDK80701.1 - 1.6 9.0 7.1 34 4.8 1.0 4.3 3 2 0 3 3 3 0 Predicted Peptidoglycan domain MFS_1_like PF12832.7 VDK80702.1 - 1.1e-77 261.5 13.5 1.4e-77 261.2 13.5 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 VDK80702.1 - 5.7e-19 68.3 27.0 1.3e-07 30.9 9.5 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Nuc_H_symport PF03825.16 VDK80702.1 - 5.9e-08 32.1 16.7 9.7e-06 24.8 5.8 2.9 3 0 0 3 3 3 2 Nucleoside H+ symporter MFS_3 PF05977.13 VDK80702.1 - 0.008 14.6 0.8 0.008 14.6 0.8 3.0 3 0 0 3 3 3 1 Transmembrane secretion effector LacY_symp PF01306.19 VDK80702.1 - 0.0086 14.9 20.1 0.088 11.6 1.6 3.1 3 0 0 3 3 3 2 LacY proton/sugar symporter DUF2873 PF11395.8 VDK80702.1 - 0.19 11.6 8.9 0.54 10.1 0.0 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2873) CAP_GLY PF01302.25 VDK80703.1 - 8.8e-48 160.2 2.6 7.6e-23 80.3 0.5 2.4 2 0 0 2 2 2 2 CAP-Gly domain CLIP1_ZNF PF16641.5 VDK80703.1 - 1.6e-16 59.7 14.6 1.2e-08 34.6 5.2 2.6 2 0 0 2 2 2 2 CLIP1 zinc knuckle BCS1_N PF08740.11 VDK80704.1 - 4.2e-37 128.0 0.2 5.5e-37 127.6 0.2 1.1 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 VDK80704.1 - 6.6e-19 68.6 0.0 1.1e-18 67.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 VDK80704.1 - 0.0061 17.0 0.0 0.018 15.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 VDK80704.1 - 0.0097 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 VDK80704.1 - 0.018 15.0 0.0 0.067 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PPV_E1_C PF00519.17 VDK80704.1 - 0.065 12.1 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase AAA_33 PF13671.6 VDK80704.1 - 0.074 13.2 0.0 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Polyoma_lg_T_C PF06431.11 VDK80704.1 - 0.082 11.8 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus RNA_helicase PF00910.22 VDK80704.1 - 0.096 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 VDK80704.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 VDK80704.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 VDK80704.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ATPase PF06745.13 VDK80704.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 VDK80704.1 - 0.15 12.3 0.0 0.37 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rsa3 PF14615.6 VDK80705.1 - 0.037 13.6 0.1 0.075 12.6 0.1 1.5 1 0 0 1 1 1 0 Ribosome-assembly protein 3 DUF5315 PF17242.2 VDK80705.1 - 0.11 12.4 3.0 0.25 11.2 0.9 2.1 1 1 1 2 2 2 0 Disordered region of unknown function (DUF5315) Med9 PF07544.13 VDK80705.1 - 0.83 9.8 5.9 0.27 11.3 1.8 2.0 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Glyco_hydro_17 PF00332.18 VDK80706.1 - 0.0057 16.3 1.8 0.068 12.7 0.2 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 POB3_N PF17292.2 VDK80706.1 - 0.33 11.4 2.0 1.5 9.3 0.4 2.4 2 1 0 2 2 2 0 POB3-like N-terminal PH domain AAA_2 PF07724.14 VDK80732.1 - 2e-40 138.7 0.3 3e-40 138.1 0.3 1.2 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 VDK80732.1 - 1.8e-13 51.1 0.3 5e-13 49.6 0.1 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 VDK80732.1 - 1e-08 35.1 0.2 2.7e-08 33.8 0.1 1.8 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 VDK80732.1 - 6.8e-07 29.4 0.0 2.4e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) MCM PF00493.23 VDK80732.1 - 2.1e-06 27.0 0.1 7.1e-06 25.3 0.0 1.8 2 0 0 2 2 2 1 MCM P-loop domain Sigma54_activat PF00158.26 VDK80732.1 - 3.1e-06 27.0 0.1 3.2e-05 23.7 0.1 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 VDK80732.1 - 2.2e-05 23.9 0.3 0.11 11.9 0.1 2.8 2 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 VDK80732.1 - 5.2e-05 23.3 0.0 0.0018 18.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 VDK80732.1 - 0.00014 21.5 0.0 0.00032 20.3 0.0 1.5 2 0 0 2 2 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 VDK80732.1 - 0.00022 21.5 0.1 0.001 19.3 0.1 2.2 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 VDK80732.1 - 0.00087 19.7 1.9 0.0056 17.1 0.1 2.6 1 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 VDK80732.1 - 0.0041 16.9 0.0 0.0086 15.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 VDK80732.1 - 0.0065 16.2 0.3 0.029 14.1 0.1 2.2 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 VDK80732.1 - 0.049 14.2 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 VDK80732.1 - 0.052 13.5 0.2 5.8 6.8 0.0 3.0 3 0 0 3 3 3 0 NACHT domain ABC_tran PF00005.27 VDK80732.1 - 0.08 13.5 0.0 0.3 11.6 0.0 1.9 2 1 0 2 2 2 0 ABC transporter Sigma54_activ_2 PF14532.6 VDK80732.1 - 0.093 12.8 0.0 0.29 11.3 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain CbiA PF01656.23 VDK80732.1 - 0.094 12.8 0.0 0.27 11.3 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_3 PF07726.11 VDK80732.1 - 0.094 12.6 0.1 0.22 11.4 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 VDK80732.1 - 0.095 12.6 0.0 0.92 9.4 0.0 2.1 1 1 1 2 2 2 0 Rad17 P-loop domain AAA_24 PF13479.6 VDK80732.1 - 0.095 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 VDK80732.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 VDK80732.1 - 0.13 11.9 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_8 PF12780.7 VDK80732.1 - 0.13 11.6 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 AAA_29 PF13555.6 VDK80732.1 - 0.18 11.6 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain C1_1 PF00130.22 VDK80732.1 - 0.27 11.1 1.4 0.52 10.2 1.4 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 VDK80732.1 - 0.27 11.3 1.8 0.54 10.3 1.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon VWA PF00092.28 VDK80733.1 - 2.1e-155 513.3 35.6 1.9e-28 99.9 0.1 10.5 9 1 1 10 10 10 10 von Willebrand factor type A domain VWA_2 PF13519.6 VDK80733.1 - 5.3e-79 261.8 20.6 6.9e-14 52.4 0.2 9.8 10 1 1 11 11 11 8 von Willebrand factor type A domain VWA_3 PF13768.6 VDK80733.1 - 1.6e-16 60.6 21.6 0.0023 17.9 0.1 9.4 9 0 0 9 9 9 5 von Willebrand factor type A domain VWA_CoxE PF05762.14 VDK80733.1 - 8.6e-12 44.9 18.2 0.13 11.6 0.1 8.1 8 1 0 8 8 8 5 VWA domain containing CoxE-like protein DUF1194 PF06707.11 VDK80733.1 - 5.3e-08 32.3 12.4 0.037 13.2 0.0 8.3 9 0 0 9 9 9 2 Protein of unknown function (DUF1194) NOG1 PF06858.14 VDK80733.1 - 3.5e-05 23.5 1.5 0.27 11.0 0.0 4.1 3 0 0 3 3 3 2 Nucleolar GTP-binding protein 1 (NOG1) Integrin_beta PF00362.18 VDK80733.1 - 0.0024 17.6 0.8 3.4 7.3 0.0 4.9 5 0 0 5 5 5 1 Integrin beta chain VWA domain Toprim_3 PF13362.6 VDK80733.1 - 0.049 14.0 2.1 1.5 9.2 0.0 4.4 5 0 0 5 5 5 0 Toprim domain Ligase_CoA PF00549.19 VDK80733.1 - 0.11 12.3 0.1 1.4 8.7 0.0 2.8 2 0 0 2 2 2 0 CoA-ligase DUF5334 PF17268.2 VDK80733.1 - 0.6 10.5 4.5 4.7 7.6 0.3 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5334) DnaJ PF00226.31 VDK80743.1 - 5.1e-28 97.0 1.6 5.1e-28 97.0 1.6 1.7 2 0 0 2 2 2 1 DnaJ domain TACC_C PF05010.14 VDK80743.1 - 0.015 15.1 3.1 0.029 14.2 3.1 1.4 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal IMS_HHH PF11798.8 VDK80743.1 - 0.061 13.7 0.2 0.19 12.2 0.2 1.9 1 0 0 1 1 1 0 IMS family HHH motif Rib_recp_KP_reg PF05104.12 VDK80743.1 - 0.3 12.1 2.5 0.51 11.4 2.5 1.3 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Brix PF04427.18 VDK80746.1 - 5.1e-14 52.8 7.7 1.8e-10 41.2 0.1 2.7 2 1 1 3 3 3 2 Brix domain AP3D1 PF06375.11 VDK80746.1 - 1.2 9.4 9.5 0.52 10.5 4.1 2.2 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Phospho_p8 PF10195.9 VDK80747.1 - 9.4e-16 58.1 5.0 1.1e-15 57.8 5.0 1.1 1 0 0 1 1 1 1 DNA-binding nuclear phosphoprotein p8 TSP_1 PF00090.19 VDK80749.1 - 3.2 8.0 10.2 4.5 7.6 7.6 2.5 2 1 0 2 2 2 0 Thrombospondin type 1 domain PDE8 PF08629.10 VDK80750.1 - 0.029 14.3 0.8 0.069 13.1 0.8 1.7 1 0 0 1 1 1 0 PDE8 phosphodiesterase TSP_1 PF00090.19 VDK80750.1 - 0.12 12.6 4.0 0.41 10.9 4.0 2.0 1 1 0 1 1 1 0 Thrombospondin type 1 domain Pkinase PF00069.25 VDK80751.1 - 4e-16 59.2 0.0 7.5e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_I PF08311.12 VDK80751.1 - 1.7e-06 28.0 1.6 3.9e-06 26.8 1.6 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase_Tyr PF07714.17 VDK80751.1 - 4e-06 26.3 0.0 8.1e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK80751.1 - 0.073 11.8 0.1 0.12 11.1 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF3316 PF11777.8 VDK80752.1 - 1 9.4 4.6 2.6 8.1 4.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3316) La PF05383.17 VDK80756.1 - 3.3e-19 68.7 0.0 6.9e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 La domain ChW PF07538.11 VDK80756.1 - 0.15 12.0 0.2 0.37 10.7 0.2 1.6 1 0 0 1 1 1 0 Clostridial hydrophobic W FAD-oxidase_C PF02913.19 VDK80776.1 - 5.9e-54 183.3 0.0 8.4e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 VDK80776.1 - 2.2e-31 108.5 0.4 3.9e-31 107.7 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain RraA-like PF03737.15 VDK80776.1 - 0.034 14.3 0.6 1.8 8.7 0.1 2.3 2 0 0 2 2 2 0 Aldolase/RraA PIH1 PF08190.12 VDK80777.1 - 2.2e-18 66.3 0.2 2.9e-15 56.1 0.1 2.1 2 0 0 2 2 2 2 PIH1 N-terminal domain Yip1 PF04893.17 VDK80778.1 - 3.5e-09 36.6 16.6 4.8e-09 36.2 16.6 1.2 1 0 0 1 1 1 1 Yip1 domain DUF4006 PF13179.6 VDK80778.1 - 0.077 12.9 0.4 0.077 12.9 0.4 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF4006) DUF3377 PF11857.8 VDK80778.1 - 1.4 8.9 3.6 24 4.9 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF202 PF02656.15 VDK80778.1 - 7.9 7.0 9.1 6.8 7.2 3.1 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF202) zf-RING_2 PF13639.6 VDK80779.1 - 2.2e-07 31.1 10.0 2.2e-07 31.1 10.0 3.0 3 0 0 3 3 1 1 Ring finger domain FANCL_C PF11793.8 VDK80779.1 - 1.5e-05 25.1 6.0 6.4e-05 23.1 6.0 2.2 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 VDK80779.1 - 5e-05 23.3 4.0 0.00016 21.7 4.0 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 VDK80779.1 - 0.00012 22.3 7.4 0.00042 20.6 7.4 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain RINGv PF12906.7 VDK80779.1 - 0.00064 19.8 8.8 0.002 18.2 8.8 2.0 1 0 0 1 1 1 1 RING-variant domain Zn_ribbon_17 PF17120.5 VDK80779.1 - 0.00085 18.9 6.6 0.00085 18.9 6.6 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 VDK80779.1 - 0.017 15.4 9.5 0.054 13.8 9.5 2.0 1 0 0 1 1 1 0 RING-like domain IFRD PF05004.13 VDK80779.1 - 0.035 13.2 1.1 1.2 8.2 0.1 3.0 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) DUF2521 PF10730.9 VDK80779.1 - 0.087 12.8 2.4 0.28 11.2 0.5 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2521) PHD PF00628.29 VDK80779.1 - 0.09 12.7 8.0 0.34 10.8 8.0 2.1 1 0 0 1 1 1 0 PHD-finger zf-RING_11 PF17123.5 VDK80779.1 - 0.13 12.0 3.2 0.46 10.3 3.2 2.1 1 0 0 1 1 1 0 RING-like zinc finger Zf_RING PF16744.5 VDK80779.1 - 0.21 11.7 4.9 0.64 10.2 4.9 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_2 PF13923.6 VDK80779.1 - 1.1 9.2 17.6 0.035 13.9 9.7 2.8 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.22 VDK80779.1 - 1.4 8.9 10.8 0.064 13.2 4.3 2.2 2 0 0 2 2 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 VDK80779.1 - 1.7 8.6 20.9 0.028 14.3 9.9 3.5 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Asp PF00026.23 VDK80780.1 - 5.7e-50 170.5 2.0 2e-42 145.7 0.3 2.1 1 1 1 2 2 2 2 Eukaryotic aspartyl protease PTPS PF01242.19 VDK80780.1 - 2.7e-21 75.8 0.2 5.5e-21 74.8 0.2 1.5 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase TAXi_N PF14543.6 VDK80780.1 - 1e-10 42.1 0.2 3.3e-08 34.0 0.2 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Pex24p PF06398.11 VDK80780.1 - 0.0013 17.8 0.0 0.0019 17.3 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin zf-U1 PF06220.12 VDK80781.1 - 2e-21 75.5 2.4 3.1e-21 74.8 2.4 1.3 1 0 0 1 1 1 1 U1 zinc finger SMN PF06003.12 VDK80781.1 - 8.6 5.5 8.3 9.5 5.4 8.3 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DNA_pol_E_B PF04042.16 VDK80783.1 - 8.2e-33 113.5 6.5 3.9e-27 95.0 3.1 2.2 1 1 1 2 2 2 2 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 VDK80783.1 - 7.6e-16 58.2 0.5 1.5e-15 57.2 0.5 1.5 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal Arfaptin PF06456.13 VDK80784.1 - 9.3e-69 231.5 5.5 1.2e-68 231.1 5.5 1.1 1 0 0 1 1 1 1 Arfaptin-like domain PDZ PF00595.24 VDK80784.1 - 4.1e-10 39.9 0.3 9.6e-10 38.7 0.3 1.6 1 1 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK80784.1 - 3.5e-08 33.2 0.0 8.9e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain BAR_3 PF16746.5 VDK80784.1 - 2.1e-06 27.7 1.9 0.00011 22.0 1.9 2.1 1 1 0 1 1 1 1 BAR domain of APPL family PDZ_2 PF13180.6 VDK80784.1 - 0.00015 22.0 0.0 0.00032 20.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 VDK80784.1 - 0.016 15.2 0.0 0.036 14.0 0.0 1.6 1 0 0 1 1 1 0 Tricorn protease PDZ domain Vps5 PF09325.10 VDK80784.1 - 0.019 14.5 2.0 3.1 7.3 0.0 2.7 2 1 1 3 3 3 0 Vps5 C terminal like DUF948 PF06103.11 VDK80784.1 - 0.21 11.8 0.4 24 5.3 0.1 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FLYWCH PF04500.16 VDK80788.1 - 6.5e-06 26.2 0.8 1.3e-05 25.2 0.8 1.5 1 0 0 1 1 1 1 FLYWCH zinc finger domain Ashwin PF15323.6 VDK80788.1 - 0.064 13.3 2.8 0.17 11.9 0.2 2.1 2 0 0 2 2 2 0 Developmental protein VWA PF00092.28 VDK80803.1 - 2.1e-20 73.7 0.1 3.3e-20 73.0 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Zona_pellucida PF00100.23 VDK80803.1 - 1.1e-11 45.0 0.3 1.5e-11 44.6 0.3 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain VWA_2 PF13519.6 VDK80803.1 - 0.00013 22.6 0.0 0.00028 21.5 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 VDK80803.1 - 0.11 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain DPM3 PF08285.11 VDK80804.1 - 8.1e-24 83.6 0.1 9.5e-24 83.4 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LRR_4 PF12799.7 VDK80805.1 - 0.073 13.5 7.7 42 4.7 0.2 5.1 3 3 2 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 VDK80805.1 - 6.3 6.6 7.5 50 3.8 0.6 4.2 6 0 0 6 6 6 0 Leucine rich repeat DIRP PF06584.13 VDK80808.1 - 1.2e-33 115.5 0.0 4.1e-33 113.7 0.0 2.0 1 0 0 1 1 1 1 DIRP DUF4168 PF13767.6 VDK80808.1 - 0.046 14.9 0.2 0.13 13.4 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4168) Aa_trans PF01490.18 VDK80810.1 - 1.3e-75 254.7 35.7 1.8e-75 254.2 35.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PRT_C PF08372.10 VDK80810.1 - 0.00045 20.0 0.3 0.0013 18.5 0.3 1.8 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal PSI_PSAK PF01241.18 VDK80810.1 - 0.024 14.6 0.1 0.024 14.6 0.1 4.1 5 0 0 5 5 5 0 Photosystem I psaG / psaK ANAPC4_WD40 PF12894.7 VDK80811.1 - 1.7e-17 63.5 0.1 4.5e-17 62.1 0.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain ANAPC4 PF12896.7 VDK80811.1 - 4e-09 36.3 1.0 4.2e-08 32.9 0.2 2.7 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 WD40 PF00400.32 VDK80811.1 - 0.14 13.1 0.0 0.42 11.6 0.0 1.9 1 0 0 1 1 1 0 WD domain, G-beta repeat DSPc PF00782.20 VDK80812.1 - 1.2e-14 54.2 0.2 6.8e-14 51.8 0.0 2.1 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK80812.1 - 0.00086 19.3 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Endostatin PF06482.11 VDK80812.1 - 0.097 12.1 2.6 0.13 11.7 2.6 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Peptidase_A21 PF03566.13 VDK80812.1 - 0.32 9.2 1.9 0.48 8.6 1.9 1.2 1 0 0 1 1 1 0 Peptidase family A21 DUF4749 PF15936.5 VDK80812.1 - 1.4 10.1 6.3 3 9.0 6.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4749) KCNQC3-Ank-G_bd PF11956.8 VDK80813.1 - 0.055 13.8 0.9 0.091 13.0 0.8 1.4 1 1 0 1 1 1 0 Ankyrin-G binding motif of KCNQ2-3 CDC45 PF02724.14 VDK80813.1 - 0.072 11.4 9.1 0.078 11.3 9.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 VDK80813.1 - 0.23 9.8 1.9 0.27 9.6 1.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 VDK80813.1 - 1 9.4 4.9 1.3 9.0 4.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDFI PF15316.6 VDK80813.1 - 2 8.5 7.4 2.9 8.0 7.4 1.3 1 0 0 1 1 1 0 MyoD family inhibitor GP63 PF17471.2 VDK80814.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Gene product 63 WEMBL PF05701.11 VDK80831.1 - 0.0057 15.4 11.3 0.008 14.9 10.9 1.4 1 1 0 1 1 1 1 Weak chloroplast movement under blue light Spc7 PF08317.11 VDK80831.1 - 0.012 14.5 13.2 0.015 14.2 13.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APCDDC PF14921.6 VDK80831.1 - 0.18 11.2 5.0 0.21 11.0 5.0 1.1 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 zf-C4H2 PF10146.9 VDK80831.1 - 0.21 11.9 13.5 0.062 13.6 1.8 2.0 1 1 1 2 2 2 0 Zinc finger-containing protein PdaC PF13739.6 VDK80831.1 - 2.7 9.0 5.4 5.2 8.1 5.4 1.7 1 1 0 1 1 1 0 Deacetylase PdaC Sec2p PF06428.11 VDK80831.1 - 3.5 7.7 16.5 10 6.2 0.2 2.6 2 1 1 3 3 3 0 GDP/GTP exchange factor Sec2p Cnn_1N PF07989.11 VDK80831.1 - 4.4 7.5 16.8 3.1 8.0 1.7 2.6 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF724 PF05266.14 VDK80831.1 - 7.8 6.3 14.0 6.3 6.6 6.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF962 PF06127.11 VDK80832.1 - 0.075 13.1 0.7 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF962) RhoGEF PF00621.20 VDK80833.1 - 1.8e-35 122.8 2.4 3.6e-35 121.9 2.4 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_9 PF14604.6 VDK80833.1 - 1.5e-13 50.4 0.1 3.2e-13 49.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK80833.1 - 5.2e-10 38.8 0.0 9.4e-10 37.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK80833.1 - 8.7e-09 34.9 0.0 2.1e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 VDK80833.1 - 2.1e-06 28.2 0.0 6.9e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 VDK80833.1 - 0.0088 16.0 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 PH domain NeA_P2 PF12312.8 VDK80833.1 - 9 5.7 8.2 18 4.7 0.1 3.2 3 0 0 3 3 3 0 Nepovirus subgroup A polyprotein Abhydrolase_1 PF00561.20 VDK80835.1 - 7e-14 52.1 0.0 3.6e-13 49.8 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK80835.1 - 4.5e-11 42.5 0.0 7.3e-10 38.5 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 VDK80835.1 - 2e-09 38.4 0.0 2.4e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 VDK80835.1 - 0.049 13.8 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain HS1_rep PF02218.15 VDK80837.1 - 1.6e-147 479.5 91.5 1.4e-19 70.1 3.6 10.4 9 1 1 10 10 10 9 Repeat in HS1/Cortactin SH3_1 PF00018.28 VDK80837.1 - 2.8e-16 58.8 0.4 6.7e-16 57.6 0.4 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK80837.1 - 6.6e-16 57.9 0.3 1.3e-15 57.0 0.3 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK80837.1 - 1.9e-08 33.8 0.0 3.8e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain TMEM210 PF15195.6 VDK80837.1 - 5.6e-08 33.2 3.8 0.26 11.7 0.0 6.5 4 3 3 7 7 7 2 TMEM210 family Trehalase PF01204.18 VDK80840.1 - 6.1e-148 493.8 1.4 7.3e-148 493.6 1.4 1.0 1 0 0 1 1 1 1 Trehalase Glyco_hydro_63 PF03200.16 VDK80840.1 - 0.00045 19.1 0.3 0.063 12.0 0.1 2.4 2 0 0 2 2 2 2 Glycosyl hydrolase family 63 C-terminal domain GDE_C PF06202.14 VDK80840.1 - 0.056 12.4 0.7 0.11 11.3 0.7 1.5 1 1 0 1 1 1 0 Amylo-alpha-1,6-glucosidase TMEM51 PF15345.6 VDK80866.1 - 0.014 15.2 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 EphA2_TM PF14575.6 VDK80866.1 - 0.053 14.4 0.0 0.073 14.0 0.0 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain NicO PF03824.16 VDK80866.1 - 0.17 11.2 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein Glycophorin_A PF01102.18 VDK80866.1 - 1.3 9.3 5.5 0.69 10.2 0.9 2.2 2 1 0 2 2 2 0 Glycophorin A Pkinase_Tyr PF07714.17 VDK80868.1 - 1.5e-85 286.6 0.0 2.3e-85 286.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK80868.1 - 4.7e-43 147.5 0.0 7.9e-43 146.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain GTPase_binding PF09027.10 VDK80868.1 - 3.7e-12 46.0 0.1 1.2e-11 44.4 0.1 1.8 1 0 0 1 1 1 1 GTPase binding UBA PF00627.31 VDK80868.1 - 0.0077 16.1 1.2 0.043 13.7 0.1 2.7 1 1 1 2 2 2 1 UBA/TS-N domain UBA_4 PF14555.6 VDK80868.1 - 0.025 14.4 1.2 0.5 10.2 0.3 2.4 2 0 0 2 2 2 0 UBA-like domain Kinase-like PF14531.6 VDK80868.1 - 0.062 12.6 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 VDK80868.1 - 0.085 12.2 0.1 0.29 10.5 0.1 1.8 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 VDK80868.1 - 0.16 10.8 0.0 0.16 10.8 0.0 3.6 3 1 0 4 4 4 0 Haspin like kinase domain APH PF01636.23 VDK80868.1 - 0.19 11.6 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Lactamase_B PF00753.27 VDK80869.1 - 2.9e-16 60.1 0.4 1.7e-14 54.3 0.4 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 VDK80869.1 - 6.1e-05 22.6 0.1 9.5e-05 22.0 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 VDK80869.1 - 0.011 15.6 0.1 0.015 15.2 0.1 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 VDK80869.1 - 0.032 13.7 0.1 0.049 13.1 0.1 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain MRP-S35 PF10246.9 VDK80871.1 - 2.5e-38 130.3 0.0 3.4e-38 129.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein MRP-S35 PFK PF00365.20 VDK80872.1 - 1.5e-188 625.0 1.4 8.3e-100 333.8 0.2 2.3 2 1 0 2 2 2 2 Phosphofructokinase PGK PF00162.19 VDK80873.1 - 1.3e-150 501.6 2.3 1.5e-150 501.4 2.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 VDK80873.1 - 0.0032 17.4 0.0 0.03 14.4 0.0 2.5 3 1 0 3 3 3 1 PA domain Sulfatase PF00884.23 VDK80876.1 - 1.5e-50 172.4 0.3 2.5e-50 171.6 0.3 1.3 1 0 0 1 1 1 1 Sulfatase DUF3740 PF12548.8 VDK80876.1 - 1.8e-06 28.5 3.0 1.8e-06 28.5 3.0 2.0 2 0 0 2 2 2 1 Sulfatase protein DUF229 PF02995.17 VDK80876.1 - 0.0018 17.0 0.0 0.003 16.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Phosphodiest PF01663.22 VDK80876.1 - 0.0063 16.1 0.0 0.012 15.2 0.0 1.5 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase eIF2A PF08662.11 VDK80883.1 - 1.4e-09 38.2 0.0 1.8e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Spc29 PF17082.5 VDK80883.1 - 0.027 14.3 0.4 0.04 13.8 0.4 1.2 1 0 0 1 1 1 0 Spindle Pole Component 29 Nup160 PF11715.8 VDK80884.1 - 8.3e-11 41.2 0.7 1e-06 27.7 0.1 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 MFS_1 PF07690.16 VDK80886.1 - 3.5e-25 88.7 28.8 1e-21 77.3 14.0 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 VDK80886.1 - 1e-07 31.2 22.8 0.00067 18.6 14.2 3.2 1 1 1 3 3 3 3 MFS_1 like family Nrap_D5 PF17406.2 VDK80887.1 - 2.5e-36 124.9 1.0 3.8e-36 124.3 0.1 1.8 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D4 PF17405.2 VDK80887.1 - 2.5e-32 112.0 0.1 5.3e-32 110.9 0.1 1.5 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D3 PF17404.2 VDK80887.1 - 1.6e-27 96.5 0.1 3.4e-27 95.5 0.1 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap PF03813.14 VDK80887.1 - 1.8e-25 89.8 0.0 3.4e-25 88.9 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D6 PF17407.2 VDK80887.1 - 1.3e-18 67.5 0.0 2.7e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 6 Nrap_D2 PF17403.2 VDK80887.1 - 1.7e-11 44.1 7.3 5.5e-11 42.5 3.9 2.7 2 1 0 2 2 2 1 Nrap protein PAP/OAS-like domain Snurportin1 PF11538.8 VDK80888.1 - 6.4e-17 61.5 7.4 1e-16 60.8 7.4 1.3 1 0 0 1 1 1 1 Snurportin1 mRNA_cap_enzyme PF01331.19 VDK80888.1 - 0.002 18.0 0.0 0.0039 17.1 0.0 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain Shikimate_DH PF01488.20 VDK80889.1 - 0.034 14.2 2.4 0.048 13.7 0.1 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase MEDS PF14417.6 VDK80889.1 - 0.038 13.8 0.6 0.053 13.3 0.6 1.1 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF569 PF04601.13 VDK80889.1 - 0.056 13.1 0.6 0.088 12.5 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF569) AvrM-A PF18241.1 VDK80889.1 - 0.34 11.3 11.0 2.5 8.5 3.5 2.2 1 1 0 2 2 2 0 Flax-rust effector AvrM-A HisK_sensor PF18698.1 VDK80889.1 - 0.6 10.5 7.7 3.8 7.9 3.8 2.4 1 1 1 2 2 2 0 Histidine kinase sensor domain DCAF17 PF15802.5 VDK80890.1 - 1.7e-18 66.6 0.0 4.1e-18 65.3 0.0 1.5 1 1 0 1 1 1 1 DDB1- and CUL4-associated factor 17 PAPS_reduct PF01507.19 VDK80891.1 - 3.8e-27 95.4 0.0 4.2e-25 88.8 0.0 2.5 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family MoCF_biosynth PF00994.24 VDK80891.1 - 2e-22 79.4 0.0 4.5e-22 78.3 0.0 1.6 1 0 0 1 1 1 1 Probable molybdopterin binding domain IBR PF01485.21 VDK80892.1 - 4.2e-18 65.3 37.7 2.7e-11 43.5 0.7 3.8 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 VDK80892.1 - 3.6e-06 27.2 0.0 1.1e-05 25.7 0.0 1.9 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 VDK80892.1 - 1.3e-05 25.5 6.7 1.3e-05 25.5 6.7 4.4 3 1 1 4 4 4 1 Ring finger domain zf-RING_5 PF14634.6 VDK80892.1 - 0.0001 22.2 11.7 0.0001 22.2 11.7 4.2 3 1 0 3 3 3 2 zinc-RING finger domain zf-C3HC4 PF00097.25 VDK80892.1 - 0.00047 20.0 7.2 0.00047 20.0 7.2 4.2 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK80892.1 - 0.00077 19.3 6.0 0.00077 19.3 6.0 4.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK80892.1 - 0.0034 17.4 7.4 0.0034 17.4 7.4 3.7 4 0 0 4 4 4 2 RING-type zinc-finger zf-RING_11 PF17123.5 VDK80892.1 - 0.02 14.6 10.0 0.02 14.6 10.0 3.1 3 0 0 3 3 3 0 RING-like zinc finger zf-piccolo PF05715.13 VDK80892.1 - 0.028 14.6 8.4 0.028 14.6 8.4 3.2 3 0 0 3 3 3 0 Piccolo Zn-finger zf-rbx1 PF12678.7 VDK80892.1 - 8.4 6.8 26.6 0.28 11.5 3.9 3.5 3 0 0 3 3 3 0 RING-H2 zinc finger domain RhoGAP PF00620.27 VDK80901.1 - 4.8e-43 146.6 1.6 8e-43 145.9 0.3 1.9 1 1 1 2 2 2 1 RhoGAP domain C1_1 PF00130.22 VDK80901.1 - 3.5e-12 46.0 10.0 7.4e-12 45.0 10.0 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.24 VDK80901.1 - 1.1e-11 44.6 0.0 2.2e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 SH2 domain Acetyltransf_11 PF13720.6 VDK80901.1 - 0.03 14.8 0.0 0.087 13.3 0.0 1.7 1 1 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 EF1_GNE PF00736.19 VDK80902.1 - 4.4e-31 106.9 1.2 6.8e-31 106.3 1.2 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 VDK80902.1 - 6.6e-12 45.7 5.4 1.8e-11 44.3 5.4 1.8 1 0 0 1 1 1 1 Eukaryotic elongation factor 1 beta central acidic region RTP1_C1 PF10363.9 VDK80904.1 - 1.3e-18 67.2 5.5 1.5e-18 67.0 0.2 3.5 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 VDK80904.1 - 1.1e-08 34.6 1.8 3.8e-08 32.9 1.8 2.1 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 HEAT_2 PF13646.6 VDK80904.1 - 0.038 14.4 6.3 1.4 9.3 0.1 3.9 3 1 1 4 4 4 0 HEAT repeats Sugar_tr PF00083.24 VDK80906.1 - 1.4e-33 116.4 21.6 2e-33 116.0 21.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK80906.1 - 8e-20 71.1 29.8 9.2e-20 70.9 24.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1356 PF07092.12 VDK80906.1 - 0.19 11.0 2.6 0.48 9.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1356) H_lectin PF09458.10 VDK80907.1 - 0.28 11.4 1.2 13 6.0 0.0 2.8 2 0 0 2 2 2 0 H-type lectin domain HPD PF05044.12 VDK80909.1 - 7.7e-39 133.0 0.1 8.5e-39 132.9 0.1 1.0 1 0 0 1 1 1 1 Homeo-prospero domain DUF4422 PF14393.6 VDK80909.1 - 0.029 14.2 0.1 0.032 14.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) HPD PF05044.12 VDK80910.1 - 1.2e-24 86.9 1.8 6.2e-24 84.6 1.1 2.3 2 0 0 2 2 2 1 Homeo-prospero domain Septin PF00735.18 VDK80921.1 - 1.3e-105 352.7 0.2 1.3e-105 352.7 0.2 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 VDK80921.1 - 1.7e-07 31.3 0.4 5.2e-07 29.7 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK80921.1 - 7.2e-05 22.2 0.1 0.00025 20.5 0.0 1.9 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 VDK80921.1 - 8.6e-05 22.5 0.0 0.003 17.5 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 VDK80921.1 - 0.00064 19.1 1.6 0.0012 18.2 0.0 2.1 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 VDK80921.1 - 0.017 15.1 4.7 1.7 8.7 0.2 3.3 2 1 0 3 3 3 0 Dynamin family AAA_22 PF13401.6 VDK80921.1 - 0.037 14.3 0.0 0.12 12.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 VDK80921.1 - 0.044 13.2 0.0 0.09 12.2 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein DUF3552 PF12072.8 VDK80921.1 - 0.14 11.5 15.8 0.24 10.8 15.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF2291 PF10054.9 VDK80921.1 - 0.15 11.8 0.4 8.3 6.1 0.0 2.4 2 0 0 2 2 2 0 Predicted periplasmic lipoprotein (DUF2291) ABC_tran PF00005.27 VDK80921.1 - 0.43 11.1 5.5 1.9 9.0 0.1 2.6 2 1 0 2 2 2 0 ABC transporter TetR_C_24 PF17932.1 VDK80921.1 - 2.3 8.5 5.5 5.7 7.2 5.5 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Calponin PF00402.18 VDK80922.1 - 0.43 10.3 2.9 0.99 9.1 0.6 2.2 2 0 0 2 2 2 0 Calponin family repeat PAP2_C PF14360.6 VDK80924.1 - 2.7e-21 75.9 8.0 2.7e-21 75.9 8.0 2.8 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 VDK80924.1 - 1.3e-05 25.0 3.2 1.3e-05 25.0 3.2 3.0 3 1 0 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 VDK80924.1 - 0.00031 20.5 7.4 0.00057 19.6 7.4 1.4 1 0 0 1 1 1 1 PAP2 superfamily Sugar_tr PF00083.24 VDK80936.1 - 4.1e-24 85.3 19.3 5.5e-24 84.8 19.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK80936.1 - 1.2e-23 83.7 34.1 9.5e-20 70.8 14.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribonuc_2-5A PF06479.12 VDK80938.1 - 0.22 11.7 1.4 4.6 7.4 0.0 2.6 1 1 2 3 3 3 0 Ribonuclease 2-5A Ribosomal_S24e PF01282.19 VDK80940.1 - 9e-34 115.3 0.0 9e-34 115.3 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein S24e BTB PF00651.31 VDK80941.1 - 1.6e-21 76.6 0.8 3.1e-21 75.7 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain MATH PF00917.26 VDK80941.1 - 1.3e-19 70.4 1.1 1.3e-19 70.4 1.1 1.8 2 0 0 2 2 2 1 MATH domain NPP PF08384.10 VDK80942.1 - 0.031 14.3 2.3 0.077 13.1 2.3 1.6 1 0 0 1 1 1 0 Pro-opiomelanocortin, N-terminal region GFO_IDH_MocA PF01408.22 VDK80942.1 - 0.072 13.9 0.1 0.14 13.0 0.1 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold IMCp PF12314.8 VDK80942.1 - 0.1 12.9 0.1 0.19 12.1 0.1 1.4 1 0 0 1 1 1 0 Inner membrane complex protein Mito_carr PF00153.27 VDK80944.1 - 1e-63 211.2 3.1 3.9e-20 71.6 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Zona_pellucida PF00100.23 VDK80944.1 - 2.7e-14 53.6 2.3 4e-14 53.0 2.3 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain Serine_protease PF18405.1 VDK80944.1 - 0.0098 15.1 0.3 0.56 9.3 0.0 3.0 3 0 0 3 3 3 1 Gammaproteobacterial serine protease LicD PF04991.13 VDK80946.1 - 5.3e-08 33.3 1.2 8.4e-07 29.4 0.4 2.5 1 1 1 2 2 2 1 LicD family Nucleoside_tran PF01733.18 VDK80947.1 - 1.6e-40 139.4 11.3 1.6e-40 139.4 11.3 1.6 1 1 1 2 2 2 1 Nucleoside transporter Death PF00531.22 VDK80957.1 - 1.1e-10 41.5 0.2 3.4e-10 40.0 0.0 1.9 2 0 0 2 2 2 1 Death domain UPA_2 PF17809.1 VDK80957.1 - 0.024 14.4 0.0 0.056 13.3 0.0 1.6 1 0 0 1 1 1 0 UPA domain TENA_THI-4 PF03070.16 VDK80957.1 - 0.031 14.1 0.3 0.074 12.8 0.2 1.6 2 0 0 2 2 2 0 TENA/THI-4/PQQC family zf-ACC PF17848.1 VDK80959.1 - 3.9 7.6 4.6 10 6.3 1.7 2.8 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Collagen PF01391.18 VDK80960.1 - 6.6e-26 89.8 79.6 8.9e-11 41.4 35.2 3.9 3 0 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK80960.1 - 1.2e-13 50.9 0.2 1.8e-13 50.3 0.2 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Hormone_recep PF00104.30 VDK80961.1 - 3.1e-16 59.6 0.4 2.1e-14 53.6 0.1 2.7 1 1 1 2 2 2 2 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 VDK80961.1 - 3.4e-06 27.4 0.5 7e-06 26.4 0.5 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) TetR_C_8 PF14278.6 VDK80961.1 - 0.013 15.6 0.1 0.47 10.6 0.0 2.7 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region Proteasome PF00227.26 VDK80962.1 - 3.4e-55 186.5 0.3 4.3e-55 186.1 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 VDK80962.1 - 6.9e-14 51.2 0.0 1.3e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF1983 PF09327.11 VDK80962.1 - 0.26 11.4 1.4 1.8 8.7 0.2 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF1983) RCC1 PF00415.18 VDK80964.1 - 1.3e-48 163.4 9.9 1.9e-12 47.6 0.1 7.8 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 VDK80964.1 - 7e-35 118.1 21.7 2.1e-08 33.7 0.9 7.8 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 VDK80964.1 - 0.037 13.8 0.3 4.5 6.9 0.0 2.9 3 0 0 3 3 3 0 TUP1-like enhancer of split Med24_N PF11277.8 VDK80969.1 - 5.4e-49 167.1 19.9 2.9e-37 128.3 7.2 3.0 2 1 1 3 3 3 3 Mediator complex subunit 24 N-terminal ANAPC3 PF12895.7 VDK80969.1 - 0.13 12.5 1.2 0.42 10.9 1.2 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Homeodomain PF00046.29 VDK80971.1 - 3.8e-21 74.7 7.9 9.5e-21 73.4 7.9 1.7 1 0 0 1 1 1 1 Homeodomain MAP65_ASE1 PF03999.12 VDK80971.1 - 0.0011 17.7 11.1 0.0013 17.5 11.1 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) SatD PF16264.5 VDK80971.1 - 0.004 16.8 0.4 0.007 16.0 0.4 1.3 1 0 0 1 1 1 1 SatD family (SatD) TAL_FSA PF00923.19 VDK80971.1 - 0.025 13.9 0.5 0.039 13.3 0.5 1.3 1 0 0 1 1 1 0 Transaldolase/Fructose-6-phosphate aldolase Homeobox_KN PF05920.11 VDK80971.1 - 0.029 14.3 0.2 0.029 14.3 0.2 2.8 3 0 0 3 3 3 0 Homeobox KN domain BTB PF00651.31 VDK80972.1 - 3e-15 56.4 0.1 7.6e-15 55.1 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain PHR PF08005.12 VDK80972.1 - 1.1e-09 39.1 0.7 8.2e-09 36.3 0.1 2.3 2 0 0 2 2 2 1 PHR domain BACK PF07707.15 VDK80972.1 - 1.6e-09 37.7 0.0 5.2e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 BTB And C-terminal Kelch hnRNP_Q_AcD PF18360.1 VDK80972.1 - 0.026 14.5 0.1 0.089 12.8 0.1 2.0 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain RasGEF PF00617.19 VDK80980.1 - 1.7e-39 135.8 0.3 3.3e-39 134.9 0.3 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 VDK80980.1 - 7.7e-10 38.9 0.1 2.3e-09 37.4 0.0 1.9 2 0 0 2 2 2 1 RasGEF N-terminal motif cNMP_binding PF00027.29 VDK80980.1 - 8e-06 25.9 0.0 2.1e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CytochromB561_N PF09786.9 VDK80981.1 - 1.4e-58 199.3 27.1 3e-52 178.4 0.0 3.2 3 0 0 3 3 3 3 Cytochrome B561, N terminal DUF2054 PF10218.9 VDK80982.1 - 2.1e-40 137.9 21.2 2.9e-40 137.4 21.2 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2054) DUF3895 PF13034.6 VDK80982.1 - 0.037 14.0 0.2 1 9.4 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3895) PhoLip_ATPase_C PF16212.5 VDK80983.1 - 4.5e-76 255.9 25.2 4.5e-76 255.9 25.2 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 VDK80983.1 - 3e-25 87.7 2.5 3e-25 87.7 2.5 2.5 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 VDK80983.1 - 4.1e-12 46.0 0.1 4.2e-11 42.8 0.0 2.6 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 VDK80983.1 - 1.4e-10 41.9 2.2 1.3e-05 25.6 0.4 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 VDK80983.1 - 9.5e-06 25.2 0.6 7.4e-05 22.3 0.0 2.8 3 0 0 3 3 3 1 E1-E2 ATPase SUIM_assoc PF16619.5 VDK80983.1 - 0.0023 18.0 5.8 0.0063 16.5 5.8 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Hydrolase_3 PF08282.12 VDK80983.1 - 0.0031 17.3 0.1 0.01 15.6 0.1 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Dimer_Tnp_hAT PF05699.14 VDK80984.1 - 2.8e-08 33.5 0.7 8.5e-08 31.9 0.0 2.2 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region CobT PF06213.12 VDK80984.1 - 0.072 12.5 1.1 0.13 11.7 1.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4499 PF14934.6 VDK80993.1 - 1.3e-15 57.5 1.6 1.4e-15 57.4 1.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4499) GCN5L1 PF06320.13 VDK80994.1 - 0.0097 16.1 4.0 0.014 15.6 4.0 1.1 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) DUF945 PF06097.11 VDK80994.1 - 0.0099 15.0 1.2 0.013 14.7 1.2 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF945) DUF1754 PF08555.10 VDK80994.1 - 0.012 16.4 17.4 0.68 10.8 17.4 2.5 1 1 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Spore_III_AB PF09548.10 VDK80994.1 - 0.018 15.1 0.6 0.15 12.2 0.2 1.9 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF4897 PF16238.5 VDK80994.1 - 0.41 10.5 5.2 0.12 12.2 1.7 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4897) Atg14 PF10186.9 VDK80995.1 - 3.5e-16 59.2 7.5 1.1e-15 57.5 0.0 2.1 2 0 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 VDK80995.1 - 8.8e-06 24.8 4.4 3.6e-05 22.9 4.2 1.9 1 1 0 1 1 1 1 Vacuolar protein sorting 38 APG6 PF04111.12 VDK80995.1 - 3.7e-05 23.8 0.0 6.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Apg6 BARA domain Clathrin PF00637.20 VDK80996.1 - 5.9e-16 58.6 3.3 6.2e-16 58.6 0.2 2.6 2 1 0 2 2 2 1 Region in Clathrin and VPS Vps39_2 PF10367.9 VDK80996.1 - 2.5e-07 31.1 0.1 1.4e-06 28.7 0.1 2.4 1 1 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 VDK80996.1 - 0.002 18.4 0.3 0.088 13.1 0.0 2.8 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 zf-rbx1 PF12678.7 VDK80996.1 - 0.0053 17.0 5.7 0.015 15.5 5.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 VDK80996.1 - 0.044 13.8 1.1 0.11 12.6 1.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger WD40 PF00400.32 VDK80996.1 - 0.069 14.1 0.7 0.27 12.2 0.1 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat zf-RING_5 PF14634.6 VDK80996.1 - 0.11 12.5 7.5 0.37 10.8 7.4 2.0 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 VDK80996.1 - 0.17 11.9 5.4 0.45 10.6 5.4 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 VDK80996.1 - 0.19 11.6 7.0 2.2 8.2 7.0 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 VDK80996.1 - 0.22 11.6 3.8 0.59 10.2 3.8 1.7 1 0 0 1 1 1 0 Zinc-finger Prok-RING_4 PF14447.6 VDK80996.1 - 0.25 11.3 6.5 0.74 9.7 6.5 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 VDK80996.1 - 0.34 10.8 8.4 2.6 7.9 8.4 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK80996.1 - 0.71 10.3 12.9 0.18 12.1 8.6 2.4 2 1 0 2 2 1 0 Ring finger domain zf-C3HC4_3 PF13920.6 VDK80996.1 - 1.4 8.8 8.2 14 5.6 8.3 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 VDK80996.1 - 6.9 6.4 6.7 43 3.8 6.7 2.2 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Ctr PF04145.15 VDK80999.1 - 6.8e-40 137.1 0.6 8.2e-40 136.8 0.6 1.1 1 0 0 1 1 1 1 Ctr copper transporter family Apyrase PF06079.11 VDK81001.1 - 9.5e-123 409.1 0.8 1.1e-122 408.8 0.8 1.0 1 0 0 1 1 1 1 Apyrase SNARE PF05739.19 VDK81005.1 - 0.062 13.3 6.6 1.2 9.2 0.1 2.3 2 0 0 2 2 2 0 SNARE domain zf-LITAF-like PF10601.9 VDK81005.1 - 0.61 10.4 3.8 6.3 7.2 0.6 2.2 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Homeodomain PF00046.29 VDK81006.1 - 5.9e-23 80.5 4.5 1.2e-22 79.5 4.5 1.5 1 0 0 1 1 1 1 Homeodomain Activator_LAG-3 PF11498.8 VDK81006.1 - 0.0099 14.9 25.7 0.011 14.8 21.9 2.5 2 0 0 2 2 2 1 Transcriptional activator LAG-3 TP_methylase PF00590.20 VDK81006.1 - 0.018 15.0 0.1 0.018 15.0 0.1 3.0 4 0 0 4 4 4 0 Tetrapyrrole (Corrin/Porphyrin) Methylases Homeobox_KN PF05920.11 VDK81006.1 - 0.098 12.6 0.2 0.098 12.6 0.2 2.0 2 0 0 2 2 2 0 Homeobox KN domain Presenilin PF01080.17 VDK81006.1 - 1.2 7.8 11.3 2.4 6.9 11.3 1.5 1 0 0 1 1 1 0 Presenilin NST1 PF13945.6 VDK81006.1 - 2.4 8.2 15.4 6.9 6.7 15.4 1.8 1 0 0 1 1 1 0 Salt tolerance down-regulator Roughex PF06020.11 VDK81006.1 - 3.3 6.7 10.3 7.2 5.6 10.3 1.6 1 0 0 1 1 1 0 Drosophila roughex protein HNF-1_N PF04814.13 VDK81015.1 - 0.085 13.5 2.5 0.13 12.9 2.5 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Myco_arth_vir_N PF09610.10 VDK81015.1 - 0.16 12.1 0.6 0.31 11.1 0.6 1.5 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Med13_C PF06333.12 VDK81015.1 - 0.28 10.4 2.9 0.38 10.0 2.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain zf-C4H2 PF10146.9 VDK81016.1 - 1.1e-45 156.6 9.2 1.3e-45 156.3 9.2 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein Imm3 PF14425.6 VDK81016.1 - 1.4e-05 25.1 0.2 2.5e-05 24.3 0.2 1.4 1 0 0 1 1 1 1 Immunity protein Imm3 zinc_ribbon_15 PF17032.5 VDK81016.1 - 0.0055 17.4 0.6 0.0055 17.4 0.6 1.8 2 0 0 2 2 2 1 zinc-ribbon family FAM184 PF15665.5 VDK81016.1 - 0.0081 16.0 0.5 0.014 15.2 0.5 1.4 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B MA-Mit PF09245.10 VDK81016.1 - 0.014 14.9 0.2 0.023 14.2 0.2 1.4 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen GTP_cyclohydro2 PF00925.20 VDK81016.1 - 0.018 14.7 0.1 0.03 13.9 0.1 1.4 1 0 0 1 1 1 0 GTP cyclohydrolase II Translin PF01997.16 VDK81016.1 - 0.02 14.9 0.2 0.02 14.9 0.2 2.0 2 1 0 2 2 2 0 Translin family Tup_N PF08581.10 VDK81016.1 - 0.033 14.5 0.6 0.15 12.4 0.2 2.2 2 0 0 2 2 2 0 Tup N-terminal DZR PF12773.7 VDK81016.1 - 0.045 13.8 3.9 0.13 12.4 3.9 1.7 1 1 0 1 1 1 0 Double zinc ribbon DHR10 PF18595.1 VDK81016.1 - 0.05 13.6 2.0 0.11 12.5 1.4 1.9 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain Seryl_tRNA_N PF02403.22 VDK81016.1 - 0.094 12.9 1.9 0.16 12.2 0.5 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain V-SNARE PF05008.15 VDK81016.1 - 0.12 12.7 2.0 3.4 8.1 0.3 3.5 3 1 0 3 3 2 0 Vesicle transport v-SNARE protein N-terminus CENP-F_leu_zip PF10473.9 VDK81016.1 - 0.13 12.3 3.2 0.49 10.4 3.3 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OmpH PF03938.14 VDK81016.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) PilJ PF13675.6 VDK81016.1 - 0.17 11.9 0.3 0.95 9.5 0.1 2.1 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term zf-ACC PF17848.1 VDK81016.1 - 0.37 10.9 3.9 8.6 6.5 3.8 2.7 1 1 1 2 2 2 0 Acetyl-coA carboxylase zinc finger domain BLOC1_2 PF10046.9 VDK81016.1 - 0.65 10.3 4.3 8.9 6.7 0.8 3.3 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C4H2 PF10146.9 VDK81017.1 - 1.8e-57 195.1 14.0 2.1e-57 194.8 14.0 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein DUF2890 PF11081.8 VDK81017.1 - 0.0034 17.5 1.9 0.0048 17.0 0.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF2890) DUF2229 PF09989.9 VDK81017.1 - 0.0054 16.4 2.6 0.0087 15.7 2.6 1.3 1 0 0 1 1 1 1 CoA enzyme activase uncharacterised domain (DUF2229) Spc7 PF08317.11 VDK81017.1 - 0.01 14.8 17.2 0.015 14.2 17.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-C3HC4_3 PF13920.6 VDK81017.1 - 0.01 15.7 4.3 0.016 15.1 4.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF5343 PF17278.2 VDK81017.1 - 0.019 15.1 1.8 0.067 13.3 1.6 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5343) V_ATPase_I PF01496.19 VDK81017.1 - 0.021 12.8 1.5 0.024 12.6 1.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DZR PF12773.7 VDK81017.1 - 0.025 14.6 1.1 0.043 13.9 1.1 1.3 1 0 0 1 1 1 0 Double zinc ribbon Glutaredoxin2_C PF04399.13 VDK81017.1 - 0.058 13.2 3.9 0.11 12.3 3.9 1.6 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Prok-RING_4 PF14447.6 VDK81017.1 - 0.061 13.2 4.0 0.11 12.3 4.0 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 FIVAR PF07554.13 VDK81017.1 - 0.088 13.6 7.6 0.14 13.0 6.8 1.7 1 1 0 1 1 1 0 FIVAR domain zf-RING_4 PF14570.6 VDK81017.1 - 0.096 12.5 3.2 0.18 11.6 3.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FapA PF03961.13 VDK81017.1 - 0.16 10.6 11.4 0.21 10.1 11.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Mgr1 PF08602.10 VDK81017.1 - 0.25 10.1 3.9 0.33 9.7 3.9 1.3 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit DUF148 PF02520.17 VDK81017.1 - 0.25 11.5 14.7 0.9 9.7 14.7 1.8 1 1 0 1 1 1 0 Domain of unknown function DUF148 DUF2258 PF10015.9 VDK81017.1 - 0.27 11.4 1.7 0.56 10.4 1.1 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) DUF948 PF06103.11 VDK81017.1 - 0.34 11.2 5.4 3 8.1 0.2 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) zf-C3HC4_2 PF13923.6 VDK81017.1 - 0.39 10.6 5.2 0.7 9.8 5.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4618 PF15397.6 VDK81017.1 - 0.46 9.9 15.4 0.78 9.1 15.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) UPF0242 PF06785.11 VDK81017.1 - 0.93 9.6 19.9 1.4 9.0 19.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Golgin_A5 PF09787.9 VDK81017.1 - 1.1 8.7 15.9 1.5 8.2 15.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF773 PF05600.12 VDK81017.1 - 1.2 7.8 14.3 0.33 9.6 8.9 2.0 1 1 1 2 2 2 0 CDK5 regulatory subunit-associated protein 3 ZapD PF07072.11 VDK81017.1 - 1.3 8.8 9.1 2.5 7.8 7.7 1.9 1 1 1 2 2 2 0 Cell division protein Jnk-SapK_ap_N PF09744.9 VDK81017.1 - 1.5 9.1 16.5 2.1 8.5 16.5 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Baculo_IE-1 PF05290.11 VDK81017.1 - 3.2 7.7 6.6 3 7.8 1.3 2.3 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Sec20 PF03908.13 VDK81017.1 - 3.4 7.7 9.0 13 5.8 1.7 2.4 1 1 0 2 2 2 0 Sec20 FTCD_C PF04961.12 VDK81017.1 - 4.4 7.0 7.0 2 8.1 4.6 1.7 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase 5_nucleotid PF05761.14 VDK81017.1 - 5.6 5.8 8.9 7.7 5.3 8.9 1.2 1 0 0 1 1 1 0 5' nucleotidase family Seryl_tRNA_N PF02403.22 VDK81017.1 - 6 7.1 16.1 37 4.6 15.8 2.1 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TMF_TATA_bd PF12325.8 VDK81017.1 - 6.4 7.0 17.3 1.6 9.0 3.5 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TMPIT PF07851.13 VDK81017.1 - 6.6 5.9 10.4 10 5.3 10.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein Collagen PF01391.18 VDK81018.1 - 3.2e-23 81.2 99.7 3.1e-09 36.4 33.6 5.0 3 1 1 4 4 4 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK81018.1 - 6.4e-15 55.0 0.5 8.7e-15 54.5 0.5 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Sigma_M_inh PF17453.2 VDK81018.1 - 0.17 12.3 0.2 0.27 11.7 0.2 1.2 1 0 0 1 1 1 0 Sigma-M inhibitor Rootletin PF15035.6 VDK81020.1 - 5.1e-38 131.0 12.5 5.1e-38 131.0 12.5 12.7 3 2 7 11 11 11 1 Ciliary rootlet component, centrosome cohesion DUF5043 PF16446.5 VDK81020.1 - 2.2 8.3 6.8 1.3 9.0 1.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5043) Microtub_bind PF13931.6 VDK81028.1 - 0.032 14.6 0.2 0.046 14.1 0.2 1.3 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding Phosphodiest PF01663.22 VDK81029.1 - 1.5e-73 248.5 0.1 2.2e-73 247.9 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase IF-2B PF01008.17 VDK81030.1 - 7.5e-41 140.2 0.1 2.7e-40 138.4 0.1 1.9 1 1 0 1 1 1 1 Initiation factor 2 subunit family PC_rep PF01851.22 VDK81033.1 - 1.6e-27 94.5 7.9 1.3e-05 25.4 0.3 6.8 6 0 0 6 6 6 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 VDK81033.1 - 7.6e-05 23.0 7.9 0.025 14.9 0.1 4.6 5 1 0 5 5 5 2 HEAT repeats TPR_19 PF14559.6 VDK81033.1 - 0.077 13.5 4.7 10 6.7 0.1 4.2 4 1 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK81033.1 - 0.99 9.7 3.6 34 4.8 0.0 3.6 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 7tm_1 PF00001.21 VDK81034.1 - 1.7e-48 165.2 14.2 2.3e-48 164.8 14.2 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 VDK81034.1 - 0.00048 19.8 15.9 0.00048 19.8 15.9 2.0 1 1 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 VDK81034.1 - 0.014 14.7 19.8 0.018 14.4 17.8 1.8 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx RPN2_C PF18004.1 VDK81035.1 - 1.2e-44 152.0 8.2 1.8e-44 151.5 8.2 1.3 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 VDK81035.1 - 4.9e-12 45.6 3.8 9e-07 29.0 0.1 2.6 2 0 0 2 2 2 2 Proteasome/cyclosome repeat HEAT_2 PF13646.6 VDK81035.1 - 4.7e-05 23.7 0.0 9.7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.6 VDK81035.1 - 0.0013 19.2 0.0 0.003 18.0 0.0 1.7 1 0 0 1 1 1 1 HEAT-like repeat HEAT PF02985.22 VDK81035.1 - 0.1 12.9 0.4 19 5.9 0.0 3.1 3 0 0 3 3 3 0 HEAT repeat Pombe_5TM PF09437.10 VDK81035.1 - 0.19 11.3 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 Pombe specific 5TM protein PRORP PF16953.5 VDK81036.1 - 1.6e-24 86.8 0.2 2.8e-24 86.0 0.2 1.3 1 0 0 1 1 1 1 Protein-only RNase P COX6B PF02297.17 VDK81036.1 - 2.2e-13 50.2 9.8 6.6e-13 48.7 9.8 1.8 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb DUF1959 PF09218.10 VDK81036.1 - 0.092 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) Sec1 PF00995.23 VDK81037.1 - 1.5e-102 344.8 4.5 1.8e-102 344.5 4.5 1.0 1 0 0 1 1 1 1 Sec1 family V-ATPase_H_C PF11698.8 VDK81037.1 - 0.0048 17.0 0.1 0.023 14.8 0.0 2.2 2 0 0 2 2 2 1 V-ATPase subunit H DivIC PF04977.15 VDK81037.1 - 0.013 15.3 2.1 4.4 7.1 0.4 2.7 2 0 0 2 2 2 0 Septum formation initiator zf-Tim10_DDP PF02953.15 VDK81043.1 - 2.3e-13 49.6 0.4 3.7e-13 48.9 0.4 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger RNase_PH PF01138.21 VDK81044.1 - 2e-07 31.6 0.0 2e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 KH_6 PF15985.5 VDK81046.1 - 6.4e-14 52.0 0.0 1.5e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 VDK81046.1 - 4.5e-13 48.8 0.0 1.1e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.9 VDK81046.1 - 0.011 16.4 2.9 1 10.0 0.1 2.6 2 1 1 3 3 3 0 Exosome component EXOSC1/CSL4 Thymopoietin PF08198.11 VDK81046.1 - 0.14 11.7 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 Thymopoietin protein Glucosamine_iso PF01182.20 VDK81047.1 - 6e-64 216.0 0.0 6.9e-64 215.8 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Arrestin_N PF00339.29 VDK81049.1 - 1.2e-37 129.2 0.0 4.1e-33 114.5 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 VDK81049.1 - 9.9e-34 116.7 0.2 1.6e-33 116.0 0.2 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain ABC_tran PF00005.27 VDK81051.1 - 9.5e-55 184.9 0.0 7.2e-28 97.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 VDK81051.1 - 2.4e-22 80.1 3.0 2.6e-07 30.7 0.0 4.8 4 1 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 VDK81051.1 - 7.7e-10 38.4 51.0 1.6e-08 34.1 28.1 4.2 3 1 1 4 4 4 2 ABC-2 family transporter protein AAA_23 PF13476.6 VDK81051.1 - 5.1e-06 27.1 0.2 0.076 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 VDK81051.1 - 8e-06 25.4 0.0 0.38 10.2 0.0 3.9 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 VDK81051.1 - 9.6e-05 22.1 0.5 0.068 12.9 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.6 VDK81051.1 - 0.011 15.9 0.0 5.5 7.3 0.0 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 VDK81051.1 - 0.05 13.5 0.0 0.78 9.6 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase MukB PF04310.12 VDK81051.1 - 0.051 13.4 0.2 3.3 7.5 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal AAA_15 PF13175.6 VDK81051.1 - 0.063 13.0 0.1 0.91 9.2 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain AAA_27 PF13514.6 VDK81051.1 - 0.096 12.3 0.1 1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 VDK81051.1 - 0.15 12.4 0.1 7.5 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain WD40 PF00400.32 VDK81054.1 - 2.7e-07 31.2 0.1 21 6.2 0.0 6.2 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK81054.1 - 4.3e-06 26.9 0.0 1.5 9.2 0.0 5.2 2 2 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Importin_rep_5 PF18816.1 VDK81055.1 - 1.1e-06 28.8 0.0 1.8e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Importin repeat DUF2605 PF10792.9 VDK81055.1 - 0.027 14.4 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Phage_cap_E PF03864.15 VDK81070.1 - 0.003 16.8 0.0 2.1 7.4 0.0 2.2 2 0 0 2 2 2 2 Phage major capsid protein E Med26 PF08711.11 VDK81071.1 - 1.9e-05 24.5 0.1 5.8e-05 23.0 0.1 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Zip PF02535.22 VDK81072.1 - 0.0014 17.9 3.4 0.0014 17.9 3.4 1.8 2 0 0 2 2 2 1 ZIP Zinc transporter Plasmodium_Vir PF05795.11 VDK81072.1 - 0.34 10.3 15.6 0.0079 15.7 6.5 2.5 3 0 0 3 3 3 0 Plasmodium vivax Vir protein SAPS PF04499.15 VDK81072.1 - 0.55 9.0 13.3 1.5 7.5 13.3 1.7 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein V_ATPase_I PF01496.19 VDK81072.1 - 1.2 7.0 10.0 0.05 11.5 4.0 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF2201_N PF13203.6 VDK81072.1 - 1.5 8.3 13.8 0.23 11.0 3.5 2.4 2 0 0 2 2 2 0 Putative metallopeptidase domain BUD22 PF09073.10 VDK81072.1 - 2.6 7.3 40.8 0.085 12.2 21.7 3.0 3 0 0 3 3 3 0 BUD22 MAP17 PF15807.5 VDK81072.1 - 2.6 8.3 12.9 0.5 10.6 8.4 2.3 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PI3K_1B_p101 PF10486.9 VDK81072.1 - 5 4.8 11.5 9.5 3.8 11.5 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2052 PF09747.9 VDK81072.1 - 5.6 7.0 30.5 0.13 12.4 16.9 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) DUF913 PF06025.12 VDK81072.1 - 7.2 5.5 18.8 3.1 6.7 6.6 3.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) FANCI_HD2 PF14680.6 VDK81074.1 - 0.098 11.9 2.0 0.19 11.0 2.0 1.4 1 0 0 1 1 1 0 FANCI helical domain 2 cwf18 PF08315.12 VDK81074.1 - 2.7 8.7 11.1 0.12 13.0 3.2 2.6 2 1 0 2 2 2 0 cwf18 pre-mRNA splicing factor CPSF100_C PF13299.6 VDK81075.1 - 0.067 13.4 3.8 0.081 13.1 3.0 1.5 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sybindin PF04099.12 VDK81076.1 - 1.8e-44 151.2 0.0 2.2e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 VDK81076.1 - 5e-06 26.7 0.0 1.2e-05 25.4 0.0 1.8 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region RE_NgoFVII PF09565.10 VDK81076.1 - 0.21 10.9 0.0 0.29 10.4 0.0 1.1 1 0 0 1 1 1 0 NgoFVII restriction endonuclease fn3 PF00041.21 VDK81078.1 - 1.2e-51 173.0 12.8 9.4e-11 41.9 0.3 9.6 9 0 0 9 9 9 8 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK81078.1 - 3.4e-14 53.2 4.1 0.00081 19.9 0.0 6.4 6 1 1 7 7 7 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 VDK81078.1 - 0.00099 19.4 0.0 8.3 6.9 0.0 4.8 5 0 0 5 5 5 1 Uncharacterised conserved protein (DUF2369) fn3_2 PF16893.5 VDK81078.1 - 0.055 13.6 0.0 18 5.6 0.0 3.9 4 0 0 4 4 4 0 Fibronectin type III domain GPI-anchored PF10342.9 VDK81078.1 - 0.095 13.5 7.6 70 4.3 0.0 6.0 5 1 2 7 7 7 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family fn3_4 PF16794.5 VDK81078.1 - 1.5 8.8 3.2 96 3.0 0.0 4.6 5 0 0 5 5 5 0 Fibronectin-III type domain Arrestin_N PF00339.29 VDK81087.1 - 9.1e-43 145.8 1.7 5.1e-41 140.1 0.2 2.1 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 VDK81087.1 - 4.6e-14 53.0 0.4 1.4e-09 38.5 0.1 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Vps26 PF03643.15 VDK81087.1 - 6.5e-07 28.6 0.0 8.3e-07 28.3 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Spo0M PF07070.11 VDK81087.1 - 3.3e-05 23.5 0.5 0.006 16.1 0.1 2.6 2 1 0 2 2 2 2 SpoOM protein Rgp1 PF08737.10 VDK81087.1 - 0.015 14.5 0.1 0.19 10.8 0.0 2.0 1 1 0 2 2 2 0 Rgp1 MG2 PF01835.19 VDK81087.1 - 0.14 12.6 0.0 6.9 7.2 0.0 2.3 2 0 0 2 2 2 0 MG2 domain SAP30_Sin3_bdg PF13867.6 VDK81089.1 - 9.1e-15 54.7 0.3 9.1e-15 54.7 0.3 2.0 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-SAP30 PF13866.6 VDK81089.1 - 0.044 13.9 0.1 0.044 13.9 0.1 2.8 3 0 0 3 3 3 0 SAP30 zinc-finger Antigen_Bd37 PF11641.8 VDK81089.1 - 0.13 11.7 2.3 0.25 10.8 2.3 1.4 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein Peptidase_S30 PF01577.16 VDK81089.1 - 0.16 11.6 12.7 0.017 14.8 7.5 1.8 2 0 0 2 2 2 0 Potyvirus P1 protease VIT1 PF01988.19 VDK81089.1 - 0.39 10.5 1.2 0.85 9.4 1.2 1.5 1 0 0 1 1 1 0 VIT family DUF3456 PF11938.8 VDK81091.1 - 1.8e-16 61.1 1.0 1.8e-16 61.1 1.0 1.8 2 1 0 2 2 2 1 TLR4 regulator and MIR-interacting MSAP SapB_1 PF05184.15 VDK81091.1 - 0.37 10.8 7.7 3 8.0 0.8 3.2 3 0 0 3 3 3 0 Saposin-like type B, region 1 Glyco_hydro_85 PF03644.13 VDK81093.1 - 3.1e-80 269.8 1.7 3.9e-80 269.5 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 Rab5-bind PF09311.11 VDK81094.1 - 1.8e-43 149.1 44.5 3.5e-25 89.0 20.6 2.1 1 1 1 2 2 2 2 Rabaptin-like protein TTR-52 PF01060.23 VDK81094.1 - 8.9e-15 55.2 0.3 3.8e-14 53.1 0.0 2.3 2 0 0 2 2 2 1 Transthyretin-like family Med9 PF07544.13 VDK81094.1 - 0.0022 18.0 1.5 0.0022 18.0 1.5 4.1 3 1 0 4 4 4 1 RNA polymerase II transcription mediator complex subunit 9 bMG3 PF11974.8 VDK81094.1 - 0.016 15.2 0.1 0.17 11.9 0.0 2.5 3 0 0 3 3 3 0 Bacterial alpha-2-macroglobulin MG3 domain HTH_Tnp_Tc3_1 PF11427.8 VDK81094.1 - 0.027 14.3 0.0 0.027 14.3 0.0 2.3 3 0 0 3 3 3 0 Tc3 transposase DUF4198 PF10670.9 VDK81094.1 - 0.049 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) CarboxypepD_reg PF13620.6 VDK81094.1 - 0.058 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Pox_A_type_inc PF04508.12 VDK81094.1 - 0.15 12.0 2.4 0.39 10.7 0.5 2.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat FUSC PF04632.12 VDK81094.1 - 1.1 7.7 1.8 1.6 7.1 1.8 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family CREPT PF16566.5 VDK81094.1 - 2 8.6 25.7 0.24 11.6 8.2 3.3 1 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour zf-Tim10_DDP PF02953.15 VDK81100.1 - 1.7e-19 69.2 1.8 2e-19 69.0 1.8 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 VDK81100.1 - 0.005 16.5 1.9 0.016 14.9 1.9 1.7 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) Chromosome_seg PF13889.6 VDK81101.1 - 1.4e-11 44.4 0.1 6.7e-11 42.2 0.1 2.3 2 0 0 2 2 2 1 Chromosome segregation during meiosis DUF4210 PF13915.6 VDK81101.1 - 2.2e-07 31.4 0.0 1.2e-06 29.0 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4210) RIO1 PF01163.22 VDK81103.1 - 9.7e-73 243.8 0.0 9.7e-73 243.8 0.0 1.7 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 VDK81103.1 - 0.00091 18.6 0.1 0.013 14.9 0.1 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 VDK81103.1 - 0.0011 17.9 0.1 0.0011 17.9 0.1 2.1 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 VDK81103.1 - 0.0024 17.3 0.0 0.006 16.0 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 VDK81103.1 - 0.0073 16.3 0.0 2.2 8.2 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family XPC-binding PF09280.11 VDK81105.1 - 0.047 13.4 0.5 0.2 11.4 0.0 2.2 2 0 0 2 2 2 0 XPC-binding domain Abhydrolase_1 PF00561.20 VDK81107.1 - 1.7e-14 54.1 0.0 3.8e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 VDK81107.1 - 1.8e-14 54.9 0.0 2.6e-14 54.3 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 VDK81107.1 - 2.8e-10 39.9 0.0 5e-10 39.1 0.0 1.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 VDK81107.1 - 2.4e-08 34.0 0.1 2.1e-06 27.6 0.1 2.8 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 VDK81107.1 - 7e-06 25.7 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Thioesterase PF00975.20 VDK81107.1 - 3.6e-05 24.0 0.0 4.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Chlorophyllase2 PF12740.7 VDK81107.1 - 0.00013 20.9 0.0 0.00018 20.5 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 VDK81107.1 - 0.00024 20.2 0.0 0.00031 19.9 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Esterase PF00756.20 VDK81107.1 - 0.0086 15.8 0.1 0.029 14.0 0.1 1.9 1 1 0 1 1 1 1 Putative esterase Palm_thioest PF02089.15 VDK81107.1 - 0.016 15.0 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Lipase_2 PF01674.18 VDK81107.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 2) DUF2974 PF11187.8 VDK81107.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) RRM_1 PF00076.22 VDK81108.1 - 2.8e-14 52.7 0.0 8e-14 51.2 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP PF02037.27 VDK81108.1 - 1.5e-08 34.2 3.2 4.8e-08 32.6 2.1 2.4 2 0 0 2 2 2 1 SAP domain RRM_5 PF13893.6 VDK81108.1 - 0.0031 17.1 0.0 0.0062 16.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RUN PF02759.19 VDK81110.1 - 0.00023 21.2 0.6 0.0012 18.8 0.6 2.3 1 1 0 1 1 1 1 RUN domain Homeodomain PF00046.29 VDK81116.1 - 4.1e-21 74.6 4.1 6.6e-21 73.9 4.1 1.3 1 0 0 1 1 1 1 Homeodomain SRP-alpha_N PF04086.13 VDK81117.1 - 6.5 6.6 17.3 7.9 6.3 17.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal NPR3 PF03666.13 VDK81117.1 - 9.6 4.9 7.9 16 4.1 7.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNase_H PF00075.24 VDK81118.1 - 1.1e-06 28.9 0.0 0.069 13.3 0.0 2.7 2 0 0 2 2 2 2 RNase H RVT_3 PF13456.6 VDK81118.1 - 0.0058 16.4 0.0 0.17 11.7 0.0 2.5 2 0 0 2 2 2 1 Reverse transcriptase-like ARID PF01388.21 VDK81120.1 - 3e-21 75.9 0.0 9e-21 74.4 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain RBB1NT PF08169.11 VDK81120.1 - 6.2e-11 42.3 0.2 2.9e-10 40.2 0.2 2.3 1 0 0 1 1 1 1 RBB1NT (NUC162) domain Tudor-knot PF11717.8 VDK81120.1 - 0.00012 21.9 1.7 0.001 18.9 1.7 2.6 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain ProQ_C PF17516.2 VDK81120.1 - 0.14 11.6 1.3 0.3 10.5 1.3 1.6 1 0 0 1 1 1 0 ProQ C-terminal domain CHCH PF06747.13 VDK81122.1 - 0.0014 18.7 6.6 0.0039 17.3 6.6 1.8 1 0 0 1 1 1 1 CHCH domain Ndufs5 PF10200.9 VDK81122.1 - 0.014 15.6 1.8 0.042 14.1 1.8 1.8 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa NAR2 PF16974.5 VDK81122.1 - 0.038 13.4 0.8 0.068 12.6 0.8 1.3 1 0 0 1 1 1 0 High-affinity nitrate transporter accessory Phage_HK97_TLTM PF06120.11 VDK81122.1 - 0.05 12.8 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 Tail length tape measure protein CX9C PF16860.5 VDK81122.1 - 0.39 10.8 5.5 0.1 12.6 1.0 2.4 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, PHD PF00628.29 VDK81123.1 - 8.1e-18 64.1 20.0 1.5e-09 37.6 4.8 2.3 1 1 1 2 2 2 2 PHD-finger PHD_2 PF13831.6 VDK81123.1 - 1.4e-06 27.8 17.9 0.0013 18.2 7.7 2.9 2 1 0 2 2 2 2 PHD-finger C1_1 PF00130.22 VDK81123.1 - 7.1e-06 25.8 15.0 0.00021 21.1 2.0 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 VDK81123.1 - 0.00024 21.3 1.9 0.00024 21.3 1.9 2.9 3 0 0 3 3 3 2 C1 domain PHD_4 PF16866.5 VDK81123.1 - 0.00093 19.2 12.9 0.00093 19.2 12.9 3.0 1 1 1 2 2 2 1 PHD-finger Zn_ribbon_17 PF17120.5 VDK81123.1 - 0.0021 17.6 2.2 0.0021 17.6 2.2 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-HC5HC2H_2 PF13832.6 VDK81123.1 - 0.028 14.6 15.9 0.097 12.8 5.4 2.4 1 1 1 2 2 2 0 PHD-zinc-finger like domain Requiem_N PF14051.6 VDK81123.1 - 0.046 13.9 1.8 0.061 13.5 0.1 2.1 2 0 0 2 2 2 0 N-terminal domain of DPF2/REQ. Ca_bind_SSO6904 PF18249.1 VDK81123.1 - 0.11 12.9 0.3 0.21 11.9 0.3 1.4 1 0 0 1 1 1 0 Calcium binding protein SSO6904 OrfB_Zn_ribbon PF07282.11 VDK81123.1 - 0.54 10.2 12.9 0.075 13.0 1.4 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Zf_RING PF16744.5 VDK81123.1 - 1.5 9.0 19.0 20 5.4 6.7 2.8 1 1 1 2 2 2 0 KIAA1045 RING finger KLRAQ PF10205.9 VDK81126.1 - 3.8e-20 72.0 8.2 3.8e-20 72.0 8.2 3.9 3 1 1 4 4 4 1 Predicted coiled-coil domain-containing protein TTKRSYEDQ PF10212.9 VDK81126.1 - 1e-18 67.6 32.8 1.9e-11 43.7 13.0 5.1 2 2 1 3 3 3 2 Predicted coiled-coil domain-containing protein TMCO5 PF14992.6 VDK81126.1 - 0.0036 16.9 17.3 0.0036 16.9 17.3 3.7 4 0 0 4 4 4 1 TMCO5 family HalX PF08663.10 VDK81126.1 - 0.056 13.8 17.4 0.073 13.4 4.0 4.8 4 0 0 4 4 4 0 HalX domain Glutaredoxin2_C PF04399.13 VDK81126.1 - 1.1 9.1 9.7 6 6.7 0.1 4.0 4 0 0 4 4 4 0 Glutaredoxin 2, C terminal domain Filament PF00038.21 VDK81126.1 - 1.6 8.2 46.3 0.23 11.0 21.2 3.7 3 2 0 3 3 3 0 Intermediate filament protein IPP-2 PF04979.14 VDK81135.1 - 1.5e-06 29.0 1.5 1.5e-06 29.0 1.5 1.0 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) HECT PF00632.25 VDK81138.1 - 1e-75 255.1 0.0 2e-75 254.2 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) MIB_HERC2 PF06701.13 VDK81138.1 - 7.6e-18 64.5 7.8 8.6e-18 64.3 2.0 3.0 2 0 0 2 2 2 1 Mib_herc2 Ank_2 PF12796.7 VDK81138.1 - 1.5e-10 41.5 0.0 6.7e-10 39.4 0.0 2.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK81138.1 - 2.3e-10 40.5 0.0 6.5e-09 35.9 0.0 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK81138.1 - 1.5e-06 28.1 0.0 0.042 14.4 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Sad1_UNC PF07738.13 VDK81138.1 - 1.5e-05 25.0 0.0 0.00038 20.5 0.0 2.6 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal Ank_4 PF13637.6 VDK81138.1 - 1.7e-05 25.3 0.0 0.0017 18.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 VDK81138.1 - 3.8e-05 23.9 0.0 0.0014 19.0 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ras PF00071.22 VDK81139.1 - 2.4e-55 186.6 0.1 2.9e-55 186.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK81139.1 - 2.4e-33 114.9 0.1 3.4e-33 114.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK81139.1 - 4.3e-15 55.6 0.0 5.3e-15 55.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK81139.1 - 0.00017 21.1 0.0 0.0002 20.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK81139.1 - 0.0089 16.1 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 VDK81139.1 - 0.011 15.6 0.1 0.24 11.1 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein TsaE PF02367.17 VDK81139.1 - 0.016 15.2 0.0 0.044 13.8 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRPRB PF09439.10 VDK81139.1 - 0.018 14.5 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 VDK81139.1 - 0.021 14.8 0.0 0.032 14.2 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 VDK81139.1 - 0.021 14.6 0.1 0.11 12.2 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 VDK81139.1 - 0.041 13.4 0.1 0.069 12.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 VDK81139.1 - 0.073 13.4 0.1 0.14 12.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 VDK81139.1 - 0.11 12.2 0.1 0.17 11.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 VDK81139.1 - 0.17 12.2 0.0 0.34 11.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ATP_bind_3 PF01171.20 VDK81140.1 - 3.8e-18 65.9 0.0 6.9e-18 65.0 0.0 1.4 1 1 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 VDK81140.1 - 2.1e-11 43.1 7.5 2.1e-11 43.1 7.5 3.1 3 0 0 3 3 3 1 Zinc-ribbon PAPS_reduct PF01507.19 VDK81140.1 - 0.0059 16.7 0.0 0.0079 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family RecR PF02132.15 VDK81140.1 - 6.8 6.4 11.3 1.3 8.7 5.0 2.8 3 0 0 3 3 3 0 RecR protein IFRD PF05004.13 VDK81141.1 - 2e-38 132.3 3.7 2.7e-38 131.8 3.7 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) IFRD_C PF04836.12 VDK81141.1 - 0.00042 20.8 8.4 0.0042 17.6 4.3 2.9 2 1 0 2 2 2 1 Interferon-related protein conserved region PAX PF00292.18 VDK81142.1 - 7.5e-72 239.1 0.6 1.2e-71 238.5 0.6 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_32 PF13565.6 VDK81142.1 - 0.00022 21.8 0.2 0.047 14.3 0.0 2.4 1 1 1 2 2 2 2 Homeodomain-like domain HTH_23 PF13384.6 VDK81142.1 - 0.0031 17.3 0.1 0.0083 15.9 0.1 1.7 1 0 0 1 1 1 1 Homeodomain-like domain Ribosomal_S13_N PF08069.12 VDK81142.1 - 0.12 12.4 0.0 0.42 10.7 0.0 1.9 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain HTH_38 PF13936.6 VDK81142.1 - 0.17 11.7 1.0 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.6 VDK81142.1 - 0.4 10.9 0.0 0.4 10.9 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Shadoo PF14999.6 VDK81142.1 - 4.6 7.3 9.7 3.5 7.7 7.6 1.8 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective LSM PF01423.22 VDK81143.1 - 1.8e-20 72.4 0.1 2.7e-20 71.8 0.1 1.3 1 0 0 1 1 1 1 LSM domain Peptidase_M16_M PF16187.5 VDK81143.1 - 0.1 11.8 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 Middle or third domain of peptidase_M16 Glutaredoxin PF00462.24 VDK81143.1 - 0.17 12.1 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin Clc-like PF07062.12 VDK81153.1 - 1.2e-87 292.9 6.9 1.4e-87 292.6 6.9 1.0 1 0 0 1 1 1 1 Clc-like Claudin_3 PF06653.11 VDK81153.1 - 0.008 16.1 12.8 0.056 13.4 0.1 2.3 2 0 0 2 2 2 2 Tight junction protein, Claudin-like Glyco_hydro_47 PF01532.20 VDK81154.1 - 2e-99 333.6 0.0 2.6e-99 333.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 tRNA-synt_2 PF00152.20 VDK81155.1 - 2.2e-52 178.1 0.6 3.1e-52 177.6 0.1 1.5 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 VDK81155.1 - 0.00033 20.6 0.1 0.001 19.0 0.1 1.9 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 VDK81155.1 - 0.036 13.5 0.2 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.20 VDK81156.1 - 2.6e-32 112.1 0.0 3.2e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) CPG4 PF15481.6 VDK81157.1 - 0.0036 17.9 5.5 0.0036 17.9 5.5 2.2 1 1 0 2 2 2 1 Chondroitin proteoglycan 4 NAPRTase_N PF17767.1 VDK81157.1 - 0.024 15.0 0.1 0.77 10.1 0.0 2.6 1 1 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain C_tripleX PF02363.19 VDK81158.1 - 9.2e-05 22.4 223.0 0.02 15.1 2.3 17.4 15 2 1 16 16 16 11 Cysteine rich repeat TMEM154 PF15102.6 VDK81159.1 - 0.00097 19.1 0.3 0.0025 17.7 0.3 1.6 1 0 0 1 1 1 1 TMEM154 protein family RAMP PF04901.13 VDK81159.1 - 0.011 15.8 0.2 0.022 14.7 0.2 1.5 1 0 0 1 1 1 0 Receptor activity modifying family DUF3377 PF11857.8 VDK81159.1 - 0.035 14.0 1.6 0.086 12.8 1.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) UL41A PF17591.2 VDK81159.1 - 0.038 14.1 1.2 0.067 13.3 0.5 1.8 2 0 0 2 2 2 0 Herpesvirus UL41A DUF2207 PF09972.9 VDK81159.1 - 0.064 12.0 0.8 0.13 11.0 0.4 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Insulin_TMD PF17870.1 VDK81159.1 - 0.38 10.8 3.7 0.77 9.9 3.7 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Sid-5 PF17204.3 VDK81159.1 - 0.91 9.7 3.8 1.9 8.7 3.8 1.5 1 0 0 1 1 1 0 Sid-5 family Orf78 PF06024.12 VDK81159.1 - 2.7 8.4 4.6 0.72 10.2 1.2 1.8 2 0 0 2 2 2 0 Orf78 (ac78) UCH PF00443.29 VDK81169.1 - 1.8e-46 158.8 1.9 1.9e-46 158.6 0.3 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK81169.1 - 2.3e-36 126.0 0.8 5.8e-36 124.7 0.8 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase AP_endonuc_2 PF01261.24 VDK81170.1 - 5.9e-36 123.9 0.0 1.5e-35 122.5 0.0 1.7 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel MBOAT PF03062.19 VDK81170.1 - 2.2e-29 102.9 13.5 2.2e-29 102.9 13.5 1.8 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Ashwin PF15323.6 VDK81170.1 - 0.12 12.4 6.8 0.18 11.8 6.8 1.2 1 0 0 1 1 1 0 Developmental protein Trypsin PF00089.26 VDK81171.1 - 1.5e-54 185.1 0.1 1.8e-54 184.9 0.1 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 VDK81171.1 - 0.0027 18.6 0.0 0.006 17.5 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain Peptidase_S6 PF02395.16 VDK81171.1 - 0.015 13.4 0.0 0.021 12.9 0.0 1.1 1 0 0 1 1 1 0 Immunoglobulin A1 protease DUF1986 PF09342.11 VDK81171.1 - 0.057 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1986) MFS_1 PF07690.16 VDK81172.1 - 1.8e-09 37.0 32.0 7.1e-05 21.9 2.7 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 VDK81172.1 - 0.00064 19.5 11.8 0.00087 19.0 8.8 2.6 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF2721 PF11026.8 VDK81172.1 - 0.34 10.8 0.1 0.34 10.8 0.1 4.4 4 1 1 5 5 5 0 Protein of unknown function (DUF2721) Vps55 PF04133.14 VDK81174.1 - 3.2e-35 120.6 11.6 3.6e-35 120.5 11.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 CitMHS PF03600.16 VDK81174.1 - 1.6 7.8 11.9 2.2 7.4 11.9 1.2 1 0 0 1 1 1 0 Citrate transporter ABC2_membrane_3 PF12698.7 VDK81174.1 - 1.7 7.7 12.1 2.1 7.3 12.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4231 PF14015.6 VDK81174.1 - 3.8 8.0 10.0 1.7 9.2 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DnaJ-X PF14308.6 VDK81175.1 - 0.036 13.5 0.2 0.036 13.5 0.2 1.7 2 0 0 2 2 2 0 X-domain of DnaJ-containing Rad9 PF04139.13 VDK81186.1 - 7.5e-56 189.4 2.1 9.6e-56 189.0 2.1 1.1 1 0 0 1 1 1 1 Rad9 Acetyltransf_3 PF13302.7 VDK81187.1 - 3.7e-23 82.7 0.1 4.3e-23 82.5 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 VDK81187.1 - 7.5e-07 29.4 0.0 9.6e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 VDK81187.1 - 5.2e-06 26.7 0.2 7.1e-06 26.2 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 VDK81187.1 - 0.0002 21.2 0.0 0.00034 20.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 VDK81187.1 - 0.00069 19.3 1.0 0.0059 16.3 1.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Lustrin_cystein PF14625.6 VDK81188.1 - 1.3e-45 153.5 177.5 3.4e-08 33.7 10.5 14.5 13 1 1 14 14 14 10 Lustrin, cysteine-rich repeated domain Kunitz_BPTI PF00014.23 VDK81188.1 - 1.3e-42 143.7 51.5 2.2e-14 53.4 10.1 6.1 6 0 0 6 6 6 4 Kunitz/Bovine pancreatic trypsin inhibitor domain EB PF01683.18 VDK81188.1 - 1.1e-13 51.2 23.2 2.3e-12 47.0 8.2 12.6 9 2 0 9 9 9 2 EB module Ion_trans PF00520.31 VDK81191.1 - 7.2e-23 81.1 14.5 1.1e-22 80.5 14.5 1.2 1 0 0 1 1 1 1 Ion transport protein CLZ PF16526.5 VDK81191.1 - 6.5e-20 71.3 3.6 1.4e-19 70.2 3.6 1.6 1 0 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels cNMP_binding PF00027.29 VDK81191.1 - 5.3e-19 68.1 0.0 9.1e-19 67.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 VDK81191.1 - 1.1 9.3 6.7 5.4 7.0 6.1 2.5 1 1 1 2 2 2 0 Ion channel MITF_TFEB_C_3_N PF15951.5 VDK81193.1 - 0.069 13.8 0.0 0.13 12.9 0.0 1.4 1 0 0 1 1 1 0 MITF/TFEB/TFEC/TFE3 N-terminus YhdX PF17444.2 VDK81195.1 - 0.59 10.0 2.5 1.1 9.2 2.5 1.4 1 0 0 1 1 1 0 Uncharacterized YhdX-like TSP_1 PF00090.19 VDK81217.1 - 4.3e-48 161.3 179.6 1.8e-08 34.5 6.7 15.1 14 0 0 14 14 14 12 Thrombospondin type 1 domain ADAM_spacer1 PF05986.14 VDK81217.1 - 3.2e-29 101.3 0.1 5.6e-29 100.5 0.1 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 Reprolysin PF01421.19 VDK81217.1 - 4.3e-21 75.7 0.1 8.8e-21 74.7 0.1 1.6 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 VDK81217.1 - 3.5e-20 72.3 10.0 3.5e-20 72.3 10.0 9.7 7 3 1 8 8 8 2 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 VDK81217.1 - 1.2e-13 51.6 0.7 2.9e-13 50.4 0.7 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12 Pep_M12B_propep PF01562.19 VDK81217.1 - 4.5e-09 36.7 0.0 1.1e-08 35.5 0.0 1.7 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin_3 PF13582.6 VDK81217.1 - 7.7e-09 36.1 0.0 2e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 VDK81217.1 - 3.4e-06 27.1 0.0 7.5e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like GON PF08685.11 VDK81219.1 - 6.9e-70 235.0 0.6 1.2e-69 234.3 0.6 1.4 1 0 0 1 1 1 1 GON domain TSP_1 PF00090.19 VDK81219.1 - 1.2e-18 67.1 73.5 5e-06 26.6 3.5 6.1 6 1 0 6 6 6 5 Thrombospondin type 1 domain ATP-synt_S1 PF05827.12 VDK81220.1 - 3.6e-22 78.8 0.2 1.1e-21 77.3 0.1 1.8 2 0 0 2 2 2 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Zn_peptidase PF04228.13 VDK81232.1 - 0.0044 16.5 0.5 0.0074 15.8 0.5 1.3 1 0 0 1 1 1 1 Putative neutral zinc metallopeptidase CLIP_SPH_mas PF18398.1 VDK81232.1 - 0.32 11.4 1.6 2.5 8.6 0.1 2.7 3 0 0 3 3 3 0 Clip-domain serine protease homolog masquerade SUIM_assoc PF16619.5 VDK81235.1 - 0.018 15.1 0.6 0.018 15.1 0.6 3.5 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 CAC1F_C PF16885.5 VDK81235.1 - 0.66 9.6 10.4 0.03 14.0 2.6 2.2 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term SelP_N PF04592.14 VDK81235.1 - 0.85 9.0 32.8 0.58 9.5 23.6 2.3 2 0 0 2 2 2 0 Selenoprotein P, N terminal region PAT1 PF09770.9 VDK81235.1 - 3.2 5.9 17.3 0.24 9.6 7.5 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 ANAPC_CDC26 PF10471.9 VDK81235.1 - 5.5 7.9 20.2 17 6.3 10.1 3.1 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Tubulin PF00091.25 VDK81237.1 - 5.3e-60 203.0 0.0 1.7e-59 201.4 0.0 1.8 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK81237.1 - 4.2e-33 114.2 0.5 7.7e-32 110.1 0.5 2.3 1 1 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK81237.1 - 0.014 15.1 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 VDK81237.1 - 0.015 14.5 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Tubulin PF00091.25 VDK81238.1 - 5.6e-60 202.9 0.0 1.1e-59 202.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK81238.1 - 3.4e-43 146.8 0.1 5.7e-43 146.1 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK81238.1 - 0.0079 15.9 0.0 0.021 14.5 0.0 1.7 1 1 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 VDK81238.1 - 0.044 13.0 0.0 0.085 12.0 0.0 1.4 1 0 0 1 1 1 0 Tubulin like DUF3287 PF11690.8 VDK81239.1 - 0.00045 19.9 0.2 0.002 17.9 0.2 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3287) Shugoshin_N PF07558.11 VDK81239.1 - 0.0086 15.9 5.3 0.27 11.1 2.9 2.6 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region LPP PF04728.13 VDK81239.1 - 0.02 15.2 1.3 0.97 9.9 0.2 2.8 3 0 0 3 3 3 0 Lipoprotein leucine-zipper ZapB PF06005.12 VDK81239.1 - 0.035 14.6 0.6 0.035 14.6 0.6 2.6 1 1 1 2 2 2 0 Cell division protein ZapB MbeD_MobD PF04899.12 VDK81239.1 - 0.47 10.6 3.9 0.88 9.7 0.5 2.4 1 1 1 2 2 2 0 MbeD/MobD like Spc24 PF08286.11 VDK81239.1 - 3 8.1 9.9 3.6 7.9 0.9 3.4 2 2 1 3 3 3 0 Spc24 subunit of Ndc80 YkyA PF10368.9 VDK81239.1 - 3.6 7.2 11.6 3.5 7.3 5.7 2.4 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein RXT2_N PF08595.11 VDK81239.1 - 5.3 7.1 11.2 0.14 12.2 3.5 2.2 2 1 0 2 2 2 0 RXT2-like, N-terminal eIF2A PF08662.11 VDK81240.1 - 1.3e-72 243.8 0.0 3.1e-71 239.3 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DUF3552 PF12072.8 VDK81241.1 - 0.0057 16.1 10.9 0.0057 16.1 10.9 4.4 2 1 1 4 4 3 1 Domain of unknown function (DUF3552) Atg14 PF10186.9 VDK81241.1 - 0.0072 15.5 1.8 0.0072 15.5 1.8 4.1 1 1 2 4 4 4 1 Vacuolar sorting 38 and autophagy-related subunit 14 Fez1 PF06818.15 VDK81241.1 - 0.016 15.6 17.9 0.016 15.6 17.9 4.6 1 1 4 5 5 5 0 Fez1 SlyX PF04102.12 VDK81241.1 - 0.017 15.7 30.2 0.066 13.8 3.7 6.8 4 3 3 7 7 7 0 SlyX Filament PF00038.21 VDK81241.1 - 0.022 14.4 52.1 0.022 14.4 21.0 4.1 1 1 1 2 2 2 0 Intermediate filament protein HMMR_N PF15905.5 VDK81241.1 - 0.18 11.3 61.0 1.7 8.0 9.4 3.6 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal Lipoprotein_22 PF17294.2 VDK81241.1 - 1 9.0 13.6 0.21 11.3 3.3 3.3 2 1 1 3 3 3 0 Uncharacterised lipoprotein family Spc7 PF08317.11 VDK81241.1 - 2.5 6.9 58.1 0.14 11.1 19.2 4.6 1 1 4 5 5 5 0 Spc7 kinetochore protein DUF4407 PF14362.6 VDK81241.1 - 5 6.4 27.5 9 5.5 12.7 3.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 VDK81241.1 - 7.9 7.0 18.5 1.6 9.2 0.2 5.7 4 2 3 7 7 7 0 Nucleopolyhedrovirus P10 protein LPP PF04728.13 VDK81241.1 - 8.5 6.8 0.0 8.5 6.8 0.0 6.3 7 1 0 7 7 7 0 Lipoprotein leucine-zipper DUF3287 PF11690.8 VDK81241.1 - 8.6 6.1 11.9 0.18 11.6 1.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3287) Lipase_3 PF01764.25 VDK81242.1 - 5.2e-12 45.8 0.1 1.3e-11 44.6 0.1 1.6 1 0 0 1 1 1 1 Lipase (class 3) RabGAP-TBC PF00566.18 VDK81251.1 - 6.3e-55 186.1 3.1 1.3e-54 185.2 3.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Lebercilin PF15619.6 VDK81254.1 - 0.0064 16.2 12.8 0.0086 15.8 12.8 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DUF4208 PF13907.6 VDK81254.1 - 0.031 14.7 1.3 0.066 13.7 1.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) MIP-T3_C PF17749.1 VDK81254.1 - 0.035 14.1 1.1 0.035 14.1 1.1 2.6 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region LPD34 PF18852.1 VDK81254.1 - 0.11 12.1 3.5 0.14 11.7 3.5 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 34 DUF745 PF05335.13 VDK81254.1 - 0.13 11.9 5.2 0.2 11.4 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) MAD PF05557.13 VDK81254.1 - 0.26 9.6 15.1 0.96 7.7 14.2 1.8 1 1 1 2 2 2 0 Mitotic checkpoint protein Transcrip_act PF04949.13 VDK81254.1 - 0.28 11.1 11.2 0.064 13.1 6.2 2.1 1 1 1 2 2 2 0 Transcriptional activator Hat1_N PF10394.9 VDK81254.1 - 0.29 11.4 2.8 0.48 10.6 2.8 1.4 1 1 0 1 1 1 0 Histone acetyl transferase HAT1 N-terminus Golgin_A5 PF09787.9 VDK81254.1 - 0.35 10.3 11.8 0.43 10.0 11.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 YscO PF07321.12 VDK81254.1 - 0.65 9.9 14.4 1 9.3 14.4 1.4 1 1 0 1 1 1 0 Type III secretion protein YscO Exonuc_VII_L PF02601.15 VDK81254.1 - 0.77 9.3 5.1 0.94 9.0 5.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PspA_IM30 PF04012.12 VDK81254.1 - 0.91 9.1 11.2 0.76 9.3 8.1 2.0 1 1 1 2 2 2 0 PspA/IM30 family DUF1664 PF07889.12 VDK81254.1 - 1.1 9.3 5.5 0.62 10.1 0.7 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) THOC7 PF05615.13 VDK81254.1 - 1.3 9.3 11.2 1.8 8.8 11.2 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 DUF4446 PF14584.6 VDK81254.1 - 1.4 8.9 6.4 9.3 6.2 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF4047 PF13256.6 VDK81254.1 - 2.2 8.5 9.1 0.33 11.1 4.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) CENP-F_leu_zip PF10473.9 VDK81254.1 - 3 7.9 16.4 0.91 9.5 10.4 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMPIT PF07851.13 VDK81254.1 - 9.9 5.3 8.6 13 4.9 8.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein DDT PF02791.17 VDK81255.1 - 6.9e-14 51.9 0.5 2.2e-13 50.3 0.2 1.9 2 0 0 2 2 2 1 DDT domain PHD PF00628.29 VDK81255.1 - 2.8e-06 27.1 10.8 6.9e-06 25.9 10.8 1.6 1 0 0 1 1 1 1 PHD-finger WSD PF15613.6 VDK81255.1 - 3.6e-06 27.4 0.1 1.2e-05 25.7 0.1 2.0 1 0 0 1 1 1 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD_2 PF13831.6 VDK81255.1 - 1.7e-05 24.3 4.5 1.7e-05 24.3 4.5 2.1 2 0 0 2 2 2 1 PHD-finger WHIM1 PF15612.6 VDK81255.1 - 0.0038 16.7 0.0 0.0078 15.7 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DUF3764 PF12594.8 VDK81255.1 - 0.045 13.8 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3764) Prok-RING_1 PF14446.6 VDK81255.1 - 0.86 9.6 6.8 2.3 8.2 6.8 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 FYVE_2 PF02318.16 VDK81255.1 - 1.3 9.3 5.8 3.3 8.0 5.8 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger CxC3 PF18804.1 VDK81255.1 - 2.7 7.9 4.6 5.4 6.9 4.6 1.4 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases TPR_1 PF00515.28 VDK81264.1 - 3.2e-22 77.3 16.2 3.4e-10 39.3 0.4 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 VDK81264.1 - 5.9e-19 66.6 12.7 1.3e-07 31.1 0.4 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 VDK81264.1 - 4.4e-18 64.7 11.4 1.5e-06 27.8 1.3 3.9 3 1 1 4 4 4 3 TPR repeat SGTA_dimer PF16546.5 VDK81264.1 - 2.8e-16 59.1 5.2 4.1e-16 58.5 1.1 2.3 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_8 PF13181.6 VDK81264.1 - 5e-11 41.9 10.6 2.7e-06 27.2 0.3 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK81264.1 - 4.7e-10 38.8 7.3 2.4e-05 24.1 0.3 3.8 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK81264.1 - 3.7e-09 36.7 7.0 4.4e-08 33.3 4.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK81264.1 - 2.6e-08 34.0 7.2 0.007 17.1 0.1 4.0 2 1 1 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK81264.1 - 3e-08 34.2 5.6 0.00013 22.5 5.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 VDK81264.1 - 1.4e-05 24.5 0.7 0.003 16.8 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK81264.1 - 2e-05 25.0 3.9 2e-05 25.0 3.9 2.7 2 1 0 3 3 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 VDK81264.1 - 4.9e-05 22.7 4.4 0.11 12.0 0.2 3.4 3 0 0 3 3 3 1 SHNi-TPR TPR_17 PF13431.6 VDK81264.1 - 0.00012 22.2 14.2 0.008 16.5 0.2 4.4 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 VDK81264.1 - 0.00096 18.9 6.2 0.03 14.2 0.5 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TOM20_plant PF06552.12 VDK81264.1 - 0.0013 18.5 2.4 0.067 12.9 0.1 3.3 2 1 1 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_9 PF13371.6 VDK81264.1 - 0.0028 17.7 4.8 0.054 13.7 4.3 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat YozE_SAM_like PF06855.12 VDK81264.1 - 0.012 15.8 0.2 0.51 10.6 0.0 3.1 3 0 0 3 3 3 0 YozE SAM-like fold Fis1_TPR_C PF14853.6 VDK81264.1 - 0.063 13.3 7.7 0.45 10.6 1.2 2.7 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 VDK81264.1 - 0.095 13.1 3.3 0.61 10.5 3.0 2.2 1 1 1 2 2 2 0 Bacterial transcriptional activator domain P-mevalo_kinase PF04275.14 VDK81264.1 - 0.096 12.6 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Phosphomevalonate kinase TPR_6 PF13174.6 VDK81264.1 - 0.63 10.8 0.1 0.63 10.8 0.1 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat GerD PF17898.1 VDK81264.1 - 2.4 8.1 6.5 0.47 10.4 0.9 2.6 3 0 0 3 3 3 0 Spore germination GerD central core domain M16C_assoc PF08367.11 VDK81264.1 - 3.6 6.7 6.4 0.14 11.2 0.5 1.6 2 0 0 2 2 2 0 Peptidase M16C associated STI1 PF17830.1 VDK81264.1 - 3.8 7.5 15.5 0.44 10.5 9.1 2.7 2 0 0 2 2 2 0 STI1 domain TPR_21 PF09976.9 VDK81264.1 - 6.8 6.3 7.5 4.5 6.9 2.8 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain XPC-binding PF09280.11 VDK81264.1 - 8.1 6.3 12.0 1.9 8.3 2.6 2.5 2 0 0 2 2 2 0 XPC-binding domain PRESAN PF09687.10 VDK81265.1 - 0.37 11.4 8.7 0.077 13.5 1.4 2.6 2 0 0 2 2 2 0 Plasmodium RESA N-terminal Muted PF14942.6 VDK81265.1 - 0.59 10.5 12.0 4 7.8 6.4 2.7 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein RICTOR_N PF14664.6 VDK81266.1 - 1.3e-43 149.4 11.4 1.7e-43 149.1 11.4 1.0 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RPN1_RPN2_N PF17781.1 VDK81266.1 - 0.11 11.9 3.0 0.13 11.7 0.9 2.1 3 0 0 3 3 3 0 RPN1/RPN2 N-terminal domain RICTOR_M PF14666.6 VDK81267.1 - 1.9e-05 24.3 0.0 4.7e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, middle domain DB PF01682.19 VDK81269.1 - 1.8e-12 47.4 7.8 1.8e-12 47.4 7.8 1.9 2 0 0 2 2 2 1 DB module RICTOR_V PF14668.6 VDK81272.1 - 3.9e-14 52.6 0.0 2.2e-13 50.2 0.0 2.2 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 VDK81272.1 - 1.5e-13 51.1 0.0 9.3e-13 48.5 0.0 2.2 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 VDK81272.1 - 9.9e-07 28.5 0.0 4.9e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, middle domain VWA PF00092.28 VDK81278.1 - 1.3e-07 32.0 0.1 4e-07 30.4 0.1 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 VDK81278.1 - 1.5e-05 25.5 0.0 8.6e-05 23.1 0.0 2.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 VDK81278.1 - 0.042 13.2 0.7 0.41 10.0 0.2 2.4 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein TUDOR PF00567.24 VDK81279.1 - 5e-17 62.1 1.6 0.00016 21.7 0.0 4.8 5 0 0 5 5 5 3 Tudor domain Spc24 PF08286.11 VDK81279.1 - 0.068 13.4 4.2 4.7 7.5 3.8 2.8 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 NUDIX PF00293.28 VDK81281.1 - 1.7e-14 54.0 0.0 2.1e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Bestrophin PF01062.21 VDK81282.1 - 3.7e-72 243.2 8.5 4.8e-72 242.9 8.5 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Peptidase_A2B PF12384.8 VDK81282.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Ty3 transposon peptidase Neur_chan_LBD PF02931.23 VDK81283.1 - 1.2e-23 83.7 2.1 1.8e-23 83.2 2.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK81283.1 - 0.038 14.0 6.2 0.08 13.0 6.2 1.6 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MRP-S28 PF10213.9 VDK81285.1 - 3.4e-19 69.5 0.4 1.4e-18 67.6 0.3 2.1 2 1 0 2 2 2 1 Mitochondrial ribosomal subunit protein COG2 PF06148.11 VDK81285.1 - 0.083 13.0 0.6 6.8 6.8 0.3 2.4 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Neur_chan_memb PF02932.16 VDK81296.1 - 5.8e-58 196.8 9.7 1.1e-34 120.5 1.1 2.4 3 0 0 3 3 3 2 Neurotransmitter-gated ion-channel transmembrane region MgtE PF01769.16 VDK81296.1 - 0.43 11.0 12.4 6.4 7.2 0.2 2.6 2 1 0 2 2 2 0 Divalent cation transporter DNA_pol_phi PF04931.13 VDK81297.1 - 4e-50 170.7 33.0 2e-30 105.6 16.1 3.3 3 1 0 3 3 3 3 DNA polymerase phi SDA1 PF05285.12 VDK81297.1 - 0.048 13.1 11.8 0.075 12.4 11.8 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 VDK81297.1 - 1.2 8.4 14.4 2.1 7.6 14.4 1.3 1 0 0 1 1 1 0 BUD22 Urb2 PF10441.9 VDK81297.1 - 3.4 7.6 5.5 4.3 7.2 0.1 3.5 4 0 0 4 4 4 0 Urb2/Npa2 family Astro_capsid_p PF12226.8 VDK81297.1 - 3.5 6.7 12.1 14 4.7 12.7 1.6 2 0 0 2 2 2 0 Turkey astrovirus capsid protein CobT PF06213.12 VDK81297.1 - 8.3 5.7 17.6 15 4.9 17.6 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Neur_chan_LBD PF02931.23 VDK81298.1 - 1.4e-50 171.8 1.4 2.3e-50 171.0 1.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK81298.1 - 1.4e-35 123.5 8.6 3.4e-31 109.1 4.2 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF1634 PF07843.11 VDK81298.1 - 0.04 14.0 2.5 0.13 12.4 2.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) Methyltransf_28 PF02636.17 VDK81304.1 - 2.6e-45 155.1 0.0 3.3e-45 154.8 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Mur_ligase_C PF02875.21 VDK81304.1 - 0.15 12.4 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Psu PF07455.11 VDK81304.1 - 0.24 11.0 0.0 0.38 10.3 0.0 1.2 1 0 0 1 1 1 0 Phage polarity suppression protein (Psu) PSI PF01437.25 VDK81306.1 - 0.21 12.2 12.7 0.37 11.4 12.7 1.4 1 0 0 1 1 1 0 Plexin repeat MGC-24 PF05283.11 VDK81306.1 - 0.26 11.7 5.1 0.44 11.0 5.1 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CMAS PF02353.20 VDK81317.1 - 3.8e-77 259.2 0.0 4.9e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 VDK81317.1 - 2e-10 41.2 0.0 4.7e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK81317.1 - 2.6e-09 37.7 0.0 1.3e-08 35.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK81317.1 - 4.5e-08 33.1 0.0 7.7e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK81317.1 - 1.8e-07 31.7 0.0 3.2e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK81317.1 - 0.00031 20.6 0.0 0.00054 19.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK81317.1 - 0.00053 19.6 0.0 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DOT1 PF08123.13 VDK81317.1 - 0.0038 16.8 0.0 0.0063 16.1 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 RrnaAD PF00398.20 VDK81317.1 - 0.0074 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PrmA PF06325.13 VDK81317.1 - 0.025 14.0 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 VDK81317.1 - 0.22 11.3 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pkinase PF00069.25 VDK81318.1 - 3.1e-16 59.5 0.0 5.7e-16 58.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81318.1 - 4e-11 42.7 0.0 2.7e-10 40.0 0.0 2.1 2 1 1 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK81318.1 - 0.018 13.9 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pollen_Ole_e_I PF01190.17 VDK81318.1 - 0.03 14.7 0.0 0.065 13.6 0.0 1.5 1 0 0 1 1 1 0 Pollen proteins Ole e I like Syncollin PF15138.6 VDK81319.1 - 0.028 14.6 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 Syncollin Cyclin_N PF00134.23 VDK81321.1 - 4.8e-30 103.9 0.0 9.7e-30 102.9 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Serglycin PF04360.12 VDK81321.1 - 0.0042 17.0 3.2 0.011 15.7 3.2 1.7 1 0 0 1 1 1 1 Serglycin Keratin PF02422.16 VDK81327.1 - 0.03 14.0 0.9 0.043 13.5 0.9 1.2 1 0 0 1 1 1 0 Keratin MSP1a PF11670.8 VDK81327.1 - 2.6 7.3 4.6 2.6 7.3 2.2 1.8 1 1 1 2 2 2 0 Major surface protein 1a (MSP1a) GCP_C_terminal PF04130.13 VDK81328.1 - 9.2e-19 68.0 7.2 2.2e-18 66.8 7.2 1.7 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 VDK81328.1 - 3.1e-18 66.5 2.2 1.1e-14 54.8 0.8 2.4 1 1 1 2 2 2 2 Gamma tubulin complex component N-terminal Sedlin_N PF04628.13 VDK81329.1 - 1.9e-21 76.5 0.8 2.4e-21 76.2 0.8 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 VDK81329.1 - 4.5e-06 26.6 0.2 7.1e-06 26.0 0.1 1.3 1 1 0 1 1 1 1 Sybindin-like family Fe_hyd_lg_C PF02906.14 VDK81332.1 - 1.2e-60 205.2 0.0 2.1e-60 204.4 0.0 1.4 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain DpaA_N PF16924.5 VDK81332.1 - 0.01 15.9 0.3 4.2 7.5 0.1 2.9 3 0 0 3 3 3 0 Dipicolinate synthase subunit A N-terminal domain DUF3150 PF11348.8 VDK81332.1 - 0.065 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) DUF4801 PF16059.5 VDK81332.1 - 1.2 9.1 4.1 0.54 10.2 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4801) CAF1C_H4-bd PF12265.8 VDK81335.1 - 3.8e-18 65.5 0.9 3e-16 59.4 0.1 2.6 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 VDK81335.1 - 1.9e-17 63.3 3.8 2.1e-05 25.2 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat eIF2A PF08662.11 VDK81335.1 - 3.5e-07 30.3 0.9 2e-06 27.8 0.3 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 VDK81335.1 - 2e-05 24.8 2.1 0.038 14.3 0.3 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Occludin_ELL PF07303.13 VDK81350.1 - 1.5e-19 70.5 8.3 1.5e-19 70.5 8.3 2.5 3 0 0 3 3 3 1 Occludin homology domain ELL PF10390.9 VDK81350.1 - 3.1e-18 66.3 7.8 3.1e-18 66.3 7.8 2.8 2 1 0 2 2 2 1 RNA polymerase II elongation factor ELL Fe-S_biosyn PF01521.20 VDK81350.1 - 0.028 14.6 0.0 0.073 13.3 0.0 1.7 1 0 0 1 1 1 0 Iron-sulphur cluster biosynthesis Ras PF00071.22 VDK81351.1 - 4.7e-67 224.6 0.4 5.4e-67 224.4 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK81351.1 - 2.1e-37 128.0 0.4 4.3e-37 127.0 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK81351.1 - 1.8e-17 63.3 0.1 2e-17 63.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK81351.1 - 1.2e-06 28.6 0.3 0.021 14.8 0.1 2.3 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 VDK81351.1 - 7.6e-06 25.4 0.0 9e-06 25.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 VDK81351.1 - 1.8e-05 24.4 0.1 4.5e-05 23.1 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 VDK81351.1 - 2e-05 24.1 0.0 2.5e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 VDK81351.1 - 2.1e-05 24.6 0.0 4e-05 23.6 0.0 1.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 VDK81351.1 - 0.0057 16.4 0.1 0.26 11.0 0.0 2.2 1 1 1 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 VDK81351.1 - 0.022 15.1 0.0 0.031 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 VDK81351.1 - 0.025 14.1 0.0 0.2 11.1 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA PF00004.29 VDK81351.1 - 0.029 14.8 0.0 0.89 10.0 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK81351.1 - 0.039 14.2 0.0 0.11 12.8 0.0 1.8 1 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 VDK81351.1 - 0.054 13.0 0.0 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 VDK81351.1 - 0.06 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 VDK81351.1 - 0.066 13.2 0.0 0.1 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 VDK81351.1 - 0.14 12.7 0.1 0.25 11.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 VDK81351.1 - 0.15 12.5 0.2 1.9 8.9 0.1 2.4 1 1 1 2 2 2 0 RNA helicase TniB PF05621.11 VDK81351.1 - 0.17 11.3 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein VWA PF00092.28 VDK81355.1 - 1.1e-47 162.6 3.0 1.2e-23 84.2 0.4 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 VDK81355.1 - 1.4e-22 80.3 0.0 7.2e-11 42.7 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.6 VDK81355.1 - 1.5e-12 47.7 0.0 3.7e-06 27.0 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 VDK81355.1 - 2.3e-09 37.0 0.0 0.00099 18.6 0.0 2.5 2 1 0 2 2 2 2 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 VDK81355.1 - 6.7e-06 26.3 0.2 3.8e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 vWA found in TerF C terminus TssR PF17643.1 VDK81355.1 - 0.026 12.5 0.1 1 7.2 0.0 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssR Myb_DNA-binding PF00249.31 VDK81356.1 - 1.9e-07 31.2 0.0 4e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-C2H2_jaz PF12171.8 VDK81356.1 - 0.00079 19.6 3.0 0.002 18.3 3.0 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding NUP PF06516.11 VDK81356.1 - 0.0019 17.5 0.2 0.0031 16.8 0.2 1.3 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) zf-C2H2_6 PF13912.6 VDK81356.1 - 0.0021 18.0 2.7 0.0063 16.5 2.7 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 VDK81356.1 - 0.0097 16.3 1.9 0.0097 16.3 1.9 2.1 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 VDK81356.1 - 0.011 16.6 2.3 0.011 16.6 2.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger Coatomer_WDAD PF04053.14 VDK81392.1 - 6e-160 533.1 0.0 1.8e-158 528.3 0.0 2.2 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 VDK81392.1 - 9.4e-38 127.6 10.3 2.1e-07 31.5 0.1 8.5 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK81392.1 - 4e-08 33.4 1.8 0.15 12.4 0.0 5.5 2 2 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 VDK81392.1 - 0.00096 19.2 0.5 1.7 8.7 0.0 4.3 2 2 3 5 5 5 1 Ciliary BBSome complex subunit 2, middle region MetallophosC PF16370.5 VDK81392.1 - 0.14 12.4 0.3 0.62 10.3 0.1 2.2 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase TAFA PF12020.8 VDK81393.1 - 0.0042 17.5 0.1 0.0049 17.3 0.1 1.1 1 0 0 1 1 1 1 TAFA family FYVE PF01363.21 VDK81395.1 - 2.7e-19 69.0 11.2 4.9e-19 68.2 11.2 1.4 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 VDK81395.1 - 5.2e-08 33.3 0.6 9.2e-08 32.5 0.1 1.7 2 0 0 2 2 2 1 PH domain FYVE_2 PF02318.16 VDK81395.1 - 0.0025 18.0 6.2 0.0051 17.0 6.2 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger IQ_SEC7_PH PF16453.5 VDK81395.1 - 0.013 15.5 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 PH domain zf-SNAP50_C PF12251.8 VDK81395.1 - 6.4 6.4 9.4 1.2 8.8 4.3 2.2 2 1 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal zf-B_box PF00643.24 VDK81395.1 - 8.6 6.6 10.9 7 6.9 7.9 2.3 2 1 0 2 2 2 0 B-box zinc finger HSP20 PF00011.21 VDK81401.1 - 1.3e-17 63.8 0.0 2.2e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK81401.1 - 0.011 15.3 0.0 0.024 14.2 0.0 1.6 1 1 0 1 1 1 0 HSP20-like domain found in ArsA 7tm_3 PF00003.22 VDK81402.1 - 1.4e-34 119.9 22.3 3.7e-34 118.5 22.3 1.8 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 VDK81402.1 - 2.4e-28 99.2 1.6 2.6e-15 56.4 0.1 2.3 2 0 0 2 2 2 2 Receptor family ligand binding region Alg14 PF08660.11 VDK81402.1 - 0.0031 17.5 0.0 0.01 15.8 0.0 1.9 2 0 0 2 2 2 1 Oligosaccharide biosynthesis protein Alg14 like CrgA PF06781.12 VDK81402.1 - 5.7 7.1 6.2 0.56 10.3 0.3 2.4 2 0 0 2 2 2 0 Cell division protein CrgA ETRAMP PF09716.10 VDK81402.1 - 7.1 6.8 7.4 70 3.6 0.2 3.9 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) zf-C2HC5 PF06221.13 VDK81414.1 - 5.2 7.1 12.4 0.3 11.1 0.5 3.1 2 1 1 3 3 3 0 Putative zinc finger motif, C2HC5-type Sugar_tr PF00083.24 VDK81415.1 - 7e-22 77.9 14.8 2.2e-14 53.2 2.3 3.5 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 VDK81415.1 - 2.3e-15 56.4 26.8 1.4e-13 50.5 12.1 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 VDK81415.1 - 0.0019 16.8 7.4 0.0019 16.8 7.4 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_4 PF06779.14 VDK81415.1 - 0.046 13.0 8.0 0.15 11.3 4.0 2.2 2 0 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB SIR2 PF02146.17 VDK81416.1 - 1e-60 204.7 0.0 2e-60 203.7 0.0 1.5 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 VDK81416.1 - 0.0002 21.2 0.0 0.00039 20.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 VDK81416.1 - 0.01 15.5 0.0 0.34 10.7 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain MMM1 PF10296.9 VDK81417.1 - 1.4e-05 24.3 1.7 0.00014 21.0 0.0 2.6 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 C1_1 PF00130.22 VDK81417.1 - 0.00027 20.8 14.4 0.00028 20.7 11.2 2.6 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) GCK PF07802.11 VDK81417.1 - 0.0074 16.7 0.1 0.035 14.5 0.1 2.2 1 0 0 1 1 1 1 GCK domain PDZ_2 PF13180.6 VDK81417.1 - 0.017 15.4 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 PDZ domain C2 PF00168.30 VDK81417.1 - 0.024 14.9 0.0 10 6.5 0.0 2.7 2 0 0 2 2 2 0 C2 domain PDZ_6 PF17820.1 VDK81417.1 - 0.062 13.1 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 PDZ domain Tricorn_PDZ PF14685.6 VDK81417.1 - 0.1 12.6 0.2 0.44 10.5 0.1 2.1 1 1 1 2 2 2 0 Tricorn protease PDZ domain C1_2 PF03107.16 VDK81417.1 - 0.81 10.1 7.2 9.7 6.6 3.9 3.0 3 0 0 3 3 3 0 C1 domain Pkinase PF00069.25 VDK81418.1 - 4.9e-54 183.4 0.0 6.6e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81418.1 - 8.7e-20 71.1 0.0 1.7e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK81418.1 - 6.7e-07 29.5 2.2 0.00029 20.8 0.0 2.5 2 1 0 3 3 3 2 Phosphotransferase enzyme family RIO1 PF01163.22 VDK81418.1 - 0.025 14.2 0.1 0.059 13.0 0.1 1.6 1 1 0 1 1 1 0 RIO1 family PBP1_TM PF14812.6 VDK81418.1 - 0.028 14.8 1.1 0.061 13.7 1.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Choline_kinase PF01633.20 VDK81418.1 - 0.089 12.4 0.3 0.16 11.5 0.3 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DB PF01682.19 VDK81426.1 - 7.7e-25 87.1 10.0 7.7e-25 87.1 10.0 1.5 2 0 0 2 2 2 1 DB module Tannase PF07519.11 VDK81426.1 - 0.012 14.5 1.1 0.016 14.2 1.1 1.1 1 0 0 1 1 1 0 Tannase and feruloyl esterase Pkinase PF00069.25 VDK81428.1 - 2.4e-21 76.3 0.0 3e-21 76.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81428.1 - 1.1e-13 51.1 0.0 1.3e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK81428.1 - 2.2e-05 23.4 0.0 3.1e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK81428.1 - 0.0099 15.8 0.0 0.12 12.3 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family UPF0139 PF03669.13 VDK81429.1 - 6.6e-44 147.7 0.7 1.5e-43 146.6 0.7 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Lactamase_B_2 PF12706.7 VDK81429.1 - 7.9e-20 71.2 0.2 1.5e-18 67.1 0.1 2.5 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 VDK81429.1 - 2.1e-11 43.3 0.0 4.2e-10 39.2 0.0 2.7 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B PF00753.27 VDK81429.1 - 4.8e-06 26.7 0.0 0.00027 21.0 0.1 3.1 3 1 0 3 3 3 1 Metallo-beta-lactamase superfamily Ras PF00071.22 VDK81430.1 - 1.4e-53 180.8 0.1 1.7e-53 180.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK81430.1 - 5.9e-28 97.5 0.0 8.5e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK81430.1 - 4.6e-15 55.5 0.0 6.2e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK81430.1 - 2.9e-07 30.6 0.0 5.1e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK81430.1 - 4.7e-07 29.4 0.0 6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 VDK81430.1 - 0.009 15.9 0.1 0.36 10.7 0.0 2.6 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 VDK81430.1 - 0.011 15.2 0.2 0.77 9.3 0.1 2.6 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain MCM PF00493.23 VDK81430.1 - 0.069 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain PduV-EutP PF10662.9 VDK81430.1 - 0.096 12.4 0.1 8.1 6.2 0.0 2.8 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 VDK81430.1 - 0.17 11.3 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 VDK81430.1 - 0.19 12.0 0.0 0.59 10.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain Actin PF00022.19 VDK81432.1 - 8e-79 265.1 0.0 1.1e-77 261.4 0.0 1.9 1 1 0 1 1 1 1 Actin RRM_1 PF00076.22 VDK81433.1 - 4.7e-40 135.3 0.1 3.1e-20 71.8 0.1 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK81433.1 - 1.4e-06 27.9 0.0 0.014 15.0 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK81433.1 - 1.9e-06 27.9 0.1 0.0055 16.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 VDK81433.1 - 0.026 14.2 0.5 3.8 7.3 0.1 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain Limkain-b1 PF11608.8 VDK81433.1 - 0.069 13.2 0.2 5.9 7.1 0.0 2.2 2 0 0 2 2 2 0 Limkain b1 Acyl_transf_3 PF01757.22 VDK81434.1 - 2.2e-19 69.7 46.3 2.2e-19 69.7 46.3 1.8 2 0 0 2 2 2 1 Acyltransferase family Tmemb_9 PF05434.11 VDK81436.1 - 6.3e-51 172.1 2.4 1.1e-50 171.3 2.4 1.3 1 0 0 1 1 1 1 TMEM9 Tenui_PVC2 PF06656.11 VDK81436.1 - 0.001 17.1 1.0 0.0013 16.8 1.0 1.1 1 0 0 1 1 1 1 Tenuivirus PVC2 protein Baculo_11_kDa PF06143.11 VDK81436.1 - 0.011 15.3 2.0 0.019 14.6 0.9 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family Shisa PF13908.6 VDK81436.1 - 0.019 15.2 0.7 0.024 14.9 0.4 1.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF5527 PF17665.1 VDK81436.1 - 0.031 13.8 0.5 0.05 13.1 0.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Orf78 PF06024.12 VDK81436.1 - 0.096 13.0 1.0 0.12 12.7 0.1 1.8 2 0 0 2 2 2 0 Orf78 (ac78) zf-C4 PF00105.18 VDK81441.1 - 1.1e-29 102.7 13.1 1.1e-29 102.7 13.1 2.3 3 0 0 3 3 3 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK81441.1 - 2.1e-21 76.5 1.2 3.8e-21 75.6 1.2 1.3 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Adeno_GP19K PF04881.13 VDK81441.1 - 0.048 13.7 0.2 0.12 12.3 0.2 1.7 1 0 0 1 1 1 0 Adenovirus GP19K ALS2CR8 PF15299.6 VDK81441.1 - 4.2 7.2 7.3 25 4.7 7.3 2.1 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Trypsin PF00089.26 VDK81443.1 - 3.1e-25 89.3 0.4 1.4e-24 87.2 0.1 2.3 2 1 0 2 2 2 1 Trypsin DUF1986 PF09342.11 VDK81443.1 - 0.00059 20.2 1.0 0.0064 16.9 0.1 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 VDK81443.1 - 0.0074 17.2 0.0 0.025 15.5 0.0 1.9 2 0 0 2 2 2 1 Trypsin-like peptidase domain HMG_box_5 PF14887.6 VDK81443.1 - 0.017 15.0 0.4 0.048 13.6 0.4 1.7 1 0 0 1 1 1 0 HMG (high mobility group) box 5 PDR_CDR PF06422.12 VDK81444.1 - 0.1 12.5 0.2 0.12 12.2 0.2 1.2 1 0 0 1 1 1 0 CDR ABC transporter Pkinase PF00069.25 VDK81445.1 - 4.2e-69 232.8 0.0 5.4e-69 232.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81445.1 - 4.1e-36 124.6 0.0 6.6e-36 123.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK81445.1 - 0.00055 19.9 0.0 0.00097 19.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 VDK81445.1 - 0.0094 14.9 1.6 0.021 13.8 1.6 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 VDK81445.1 - 0.015 14.7 0.0 0.025 13.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 VDK81445.1 - 0.024 14.2 0.1 0.038 13.6 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 VDK81445.1 - 0.074 12.4 0.2 0.13 11.6 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_M3 PF01432.20 VDK81457.1 - 1.9e-83 281.3 0.0 2.5e-83 280.9 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 MutS_V PF00488.21 VDK81458.1 - 1.3e-68 230.7 0.0 3e-68 229.6 0.0 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 VDK81458.1 - 2.5e-32 112.7 0.2 7.8e-32 111.0 0.0 2.0 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 VDK81458.1 - 4.5e-07 30.1 0.1 1e-06 29.0 0.1 1.6 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 VDK81458.1 - 1.4e-06 28.6 0.3 4e-06 27.1 0.2 1.8 1 1 0 1 1 1 1 MutS domain I MutS_II PF05188.17 VDK81458.1 - 0.00023 21.4 0.8 0.00052 20.3 0.1 1.9 2 0 0 2 2 2 1 MutS domain II RNase_H2-Ydr279 PF09468.10 VDK81459.1 - 1.7e-07 31.5 2.3 2.9e-07 30.8 0.8 2.0 2 0 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 VDK81459.1 - 7.9e-05 22.8 0.0 0.00035 20.8 0.0 2.0 1 1 1 2 2 2 1 Ydr279p protein triple barrel domain EGF_CA PF07645.15 VDK81460.1 - 1.2e-78 259.1 143.6 5.5e-11 42.5 7.6 12.0 11 2 2 13 13 13 9 Calcium-binding EGF domain cEGF PF12662.7 VDK81460.1 - 4.7e-54 179.9 86.4 2.1e-09 37.2 2.5 11.0 11 0 0 11 11 11 9 Complement Clr-like EGF-like FXa_inhibition PF14670.6 VDK81460.1 - 3.9e-26 91.0 155.1 3.2e-08 33.7 5.9 11.9 12 1 0 12 12 12 9 Coagulation Factor Xa inhibitory site EGF_3 PF12947.7 VDK81460.1 - 2.2e-16 59.7 115.4 1.2e-05 25.4 4.3 11.6 10 1 0 11 11 11 9 EGF domain hEGF PF12661.7 VDK81460.1 - 4.7e-13 49.2 94.9 0.00019 21.9 3.7 13.8 13 2 0 13 13 13 5 Human growth factor-like EGF EGF PF00008.27 VDK81460.1 - 3.3e-08 33.7 113.5 0.00042 20.6 3.3 13.4 12 3 0 12 12 12 6 EGF-like domain Plasmod_Pvs28 PF06247.11 VDK81460.1 - 0.025 14.9 93.1 0.087 13.1 0.7 11.5 9 2 1 10 10 10 0 Pvs28 EGF domain Lipid_DES PF08557.10 VDK81462.1 - 0.099 12.2 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) 60KD_IMP PF02096.20 VDK81462.1 - 0.15 11.9 6.9 0.024 14.6 2.4 1.9 2 1 0 2 2 2 0 60Kd inner membrane protein PCI PF01399.27 VDK81464.1 - 2.5e-15 56.9 3.5 3.3e-15 56.5 0.5 2.6 2 1 0 2 2 2 1 PCI domain RPN7 PF10602.9 VDK81464.1 - 2.2e-05 24.2 0.7 7.3e-05 22.5 0.4 1.8 1 1 0 1 1 1 1 26S proteasome subunit RPN7 TPR_19 PF14559.6 VDK81464.1 - 0.00074 20.0 1.1 0.07 13.6 0.1 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK81464.1 - 0.0035 17.4 1.2 4.2 7.8 0.0 3.3 3 0 0 3 3 2 2 Tetratricopeptide repeat CSN4_RPN5_eIF3a PF18420.1 VDK81464.1 - 0.038 14.2 0.1 0.11 12.7 0.1 1.8 1 0 0 1 1 1 0 CSN4/RPN5/eIF3a helix turn helix domain YfdX PF10938.8 VDK81464.1 - 0.055 13.4 0.5 0.21 11.5 0.1 2.2 3 0 0 3 3 3 0 YfdX protein TPR_12 PF13424.6 VDK81464.1 - 0.12 12.7 7.8 0.11 12.8 0.6 3.8 5 1 1 6 6 6 0 Tetratricopeptide repeat DUF3926 PF13080.6 VDK81464.1 - 0.12 12.3 0.3 1.9 8.5 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3926) SPO22 PF08631.10 VDK81464.1 - 0.6 9.5 5.0 0.76 9.2 2.5 2.3 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_2 PF07719.17 VDK81464.1 - 1.5 9.1 3.5 59 4.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK81464.1 - 2.9 8.9 4.5 1.2e+02 3.9 0.1 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat DOMON PF03351.17 VDK81473.1 - 2e-88 293.0 13.4 2.2e-26 92.5 0.0 6.1 5 1 0 5 5 5 5 DOMON domain TIL PF01826.17 VDK81473.1 - 2.9e-20 72.3 71.4 3e-08 33.8 16.4 4.5 4 0 0 4 4 4 3 Trypsin Inhibitor like cysteine rich domain SEA PF01390.20 VDK81473.1 - 1.7e-05 24.9 2.0 3.3e-05 23.9 0.0 2.5 2 0 0 2 2 2 1 SEA domain Dicty_REP PF05086.12 VDK81473.1 - 3.9 5.3 6.7 6.3 4.7 6.7 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Bromodomain PF00439.25 VDK81478.1 - 4.8e-13 49.0 0.0 1.2e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 Bromodomain Zw10 PF06248.13 VDK81478.1 - 0.011 14.4 0.8 0.018 13.7 0.8 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 DUF5027 PF16430.5 VDK81479.1 - 0.094 12.5 0.0 0.16 11.7 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5027) DUF3402 PF11882.8 VDK81481.1 - 4e-91 306.5 16.8 3.9e-54 184.5 5.7 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) fn3 PF00041.21 VDK81490.1 - 9.9e-39 131.6 29.6 3.6e-10 40.0 1.4 6.5 6 0 0 6 6 6 6 Fibronectin type III domain DB PF01682.19 VDK81490.1 - 2.5e-35 120.8 102.7 2.8e-12 46.8 12.8 6.7 5 2 1 6 6 5 4 DB module I-set PF07679.16 VDK81490.1 - 1.9e-16 59.9 0.3 2.1e-08 34.1 0.0 4.6 3 1 0 3 3 3 2 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK81490.1 - 5.7e-11 42.9 10.4 3.8e-05 24.2 0.0 6.0 5 1 0 5 5 5 2 Immunoglobulin domain Lustrin_cystein PF14625.6 VDK81490.1 - 1.1e-08 35.3 8.2 1.1e-08 35.3 8.2 4.9 5 0 0 5 5 1 1 Lustrin, cysteine-rich repeated domain ig PF00047.25 VDK81490.1 - 5.9e-07 29.6 1.5 0.17 12.0 0.0 3.9 4 0 0 4 4 4 2 Immunoglobulin domain Interfer-bind PF09294.10 VDK81490.1 - 2e-05 24.8 12.9 0.015 15.6 0.0 5.6 6 0 0 6 6 6 1 Interferon-alpha/beta receptor, fibronectin type III V-set PF07686.17 VDK81490.1 - 3.6e-05 23.9 3.9 0.008 16.3 0.1 4.9 5 1 0 5 5 5 1 Immunoglobulin V-set domain Izumo-Ig PF16706.5 VDK81490.1 - 0.00074 19.5 0.1 0.0026 17.8 0.1 1.9 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Glyco_hydro_36C PF16874.5 VDK81490.1 - 0.0092 16.5 0.0 13 6.4 0.0 3.8 4 0 0 4 4 3 1 Glycosyl hydrolase family 36 C-terminal domain Adeno_E3_CR1 PF02440.15 VDK81490.1 - 0.13 12.1 1.3 0.83 9.5 0.8 2.7 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 Pur_ac_phosph_N PF16656.5 VDK81490.1 - 0.26 11.9 29.7 0.89 10.2 0.2 7.2 5 3 0 5 5 5 0 Purple acid Phosphatase, N-terminal domain SusE PF14292.6 VDK81490.1 - 1.3 9.3 5.9 2.7 8.2 0.1 3.6 3 0 0 3 3 3 0 SusE outer membrane protein RIC3 PF15361.6 VDK81491.1 - 5.9e-31 107.8 0.5 1.5e-30 106.5 0.0 1.8 2 0 0 2 2 2 1 Resistance to inhibitors of cholinesterase homologue 3 DUF2203 PF09969.9 VDK81491.1 - 0.0067 17.1 1.0 0.013 16.2 1.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) VirD1 PF07328.11 VDK81491.1 - 0.0073 16.3 0.1 0.01 15.8 0.1 1.2 1 0 0 1 1 1 1 T-DNA border endonuclease VirD1 CcmH PF03918.14 VDK81491.1 - 0.089 12.1 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Cytochrome C biogenesis protein CTP_transf_1 PF01148.20 VDK81493.1 - 6.2e-84 281.9 26.3 7.4e-84 281.6 26.3 1.0 1 0 0 1 1 1 1 Cytidylyltransferase family Mito_carr PF00153.27 VDK81495.1 - 5.4e-69 228.2 0.7 1e-24 86.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Caveolin PF01146.17 VDK81496.1 - 4.4e-36 123.8 0.4 6e-36 123.3 0.4 1.1 1 0 0 1 1 1 1 Caveolin PAN_4 PF14295.6 VDK81497.1 - 0.011 15.6 0.1 0.026 14.4 0.1 1.6 1 0 0 1 1 1 0 PAN domain PglL_A PF15864.5 VDK81497.1 - 0.33 10.7 3.3 17 5.2 0.7 2.7 2 0 0 2 2 2 0 Protein glycosylation ligase SAC3_GANP PF03399.16 VDK81505.1 - 2.4e-98 329.1 9.6 5.5e-98 328.0 9.6 1.6 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 VDK81505.1 - 0.00014 21.9 0.3 0.001 19.1 0.0 2.4 1 1 1 2 2 2 1 CSN8/PSMD8/EIF3K family Omp28 PF11551.8 VDK81505.1 - 0.13 12.1 0.1 0.28 11.0 0.1 1.5 1 0 0 1 1 1 0 Outer membrane protein Omp28 EMP24_GP25L PF01105.24 VDK81507.1 - 7.1e-10 39.1 4.1 8.3e-10 38.9 4.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD STATa_Ig PF18214.1 VDK81507.1 - 0.0039 17.2 1.8 0.0061 16.6 1.8 1.3 1 0 0 1 1 1 1 STATa Immunoglobulin-like domain G-alpha PF00503.20 VDK81508.1 - 1.4e-122 409.3 6.0 1.6e-122 409.1 6.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 VDK81508.1 - 9.2e-18 64.3 2.4 3.5e-13 49.4 0.7 2.9 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK81508.1 - 3.2e-06 26.7 8.2 5.2e-05 22.7 1.9 2.7 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region Roc PF08477.13 VDK81508.1 - 7.1e-05 23.0 0.7 0.14 12.4 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK81508.1 - 0.014 15.0 3.2 0.42 10.2 1.1 2.5 2 1 0 2 2 2 0 Ras family TniB PF05621.11 VDK81508.1 - 0.027 13.9 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 VDK81508.1 - 0.086 12.6 0.1 0.24 11.2 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain 7tm_1 PF00001.21 VDK81513.1 - 2.7e-48 164.6 11.1 2.7e-48 164.6 11.1 1.7 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK81513.1 - 1.3e-05 24.7 2.5 1.3e-05 24.7 2.5 2.2 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx GDP_Man_Dehyd PF16363.5 VDK81516.1 - 2.5e-57 194.8 0.0 7.6e-57 193.2 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 VDK81516.1 - 2.3e-49 168.1 0.1 2.9e-49 167.7 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 VDK81516.1 - 1.2e-10 41.1 0.4 7.8e-07 28.5 0.0 2.2 1 1 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 VDK81516.1 - 2.4e-10 39.9 0.0 8.6e-10 38.1 0.0 1.7 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 VDK81516.1 - 8e-10 38.3 0.0 1.1e-09 37.8 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 VDK81516.1 - 3.3e-08 33.0 0.2 0.0011 18.2 0.1 2.8 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein adh_short PF00106.25 VDK81516.1 - 0.1 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase NAD_binding_10 PF13460.6 VDK81516.1 - 0.17 11.8 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding zf_CCCH_4 PF18345.1 VDK81519.1 - 7.7e-07 29.0 2.8 1.4e-06 28.2 2.8 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 VDK81519.1 - 6.8e-05 22.6 1.9 0.00013 21.6 1.9 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 VDK81519.1 - 0.00032 21.4 0.0 0.0023 18.6 0.0 2.4 2 0 0 2 2 2 1 Torus domain zf-CCCH PF00642.24 VDK81519.1 - 0.00089 19.1 0.3 0.0017 18.2 0.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) UPF0086 PF01868.16 VDK81521.1 - 1.2e-23 82.8 0.0 1.9e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 MFP2b PF12150.8 VDK81522.1 - 3.1e-07 30.0 0.0 3.7e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Cytosolic motility protein GMP_PDE_delta PF05351.11 VDK81522.1 - 0.013 15.5 0.0 0.03 14.4 0.0 1.5 2 0 0 2 2 2 0 GMP-PDE, delta subunit DUF913 PF06025.12 VDK81523.1 - 0.078 12.0 0.2 0.1 11.6 0.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TRAPP PF04051.16 VDK81531.1 - 2e-40 137.9 0.1 2.5e-40 137.6 0.1 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4355 PF14265.6 VDK81532.1 - 3.2 8.0 8.0 0.26 11.5 2.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Sugar_tr PF00083.24 VDK81533.1 - 2.1e-24 86.2 19.6 3.3e-22 79.0 10.1 2.3 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 VDK81533.1 - 7.9e-23 80.9 36.2 7.9e-22 77.7 20.1 2.3 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_4 PF06779.14 VDK81533.1 - 7.6e-09 35.3 8.9 0.00012 21.5 0.6 2.1 1 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Caps_synth_CapC PF14102.6 VDK81533.1 - 6.3 7.2 16.0 23 5.4 0.3 4.3 4 0 0 4 4 4 0 Capsule biosynthesis CapC DUF2222 PF09984.9 VDK81534.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) TANGO2 PF05742.12 VDK81535.1 - 5.4e-49 167.5 0.0 6.1e-49 167.3 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 TANGO2 PF05742.12 VDK81537.1 - 7.2e-48 163.8 0.4 9.7e-23 81.5 0.3 2.0 1 1 1 2 2 2 2 Transport and Golgi organisation 2 TRA-1_regulated PF02343.16 VDK81537.1 - 0.015 15.3 0.0 0.3 11.2 0.0 2.2 2 0 0 2 2 2 0 TRA-1 regulated protein R03H10.4 Glycos_transf_4 PF00953.21 VDK81539.1 - 3.2e-35 121.4 14.2 3.2e-35 121.4 14.2 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF1768 PF08719.11 VDK81540.1 - 4e-43 147.4 0.0 6.2e-43 146.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) VIR_N PF15912.5 VDK81540.1 - 0.2 11.3 4.2 0.37 10.3 4.2 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal OrfB_IS605 PF01385.19 VDK81540.1 - 3.8 7.8 6.6 24 5.2 2.4 2.4 2 0 0 2 2 2 0 Probable transposase IFT20 PF14931.6 VDK81543.1 - 0.024 14.8 1.8 0.058 13.6 1.8 1.6 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 Ribosom_S30AE_C PF16321.5 VDK81543.1 - 0.041 13.6 1.2 9.5 6.0 0.0 2.6 2 0 0 2 2 2 0 Sigma 54 modulation/S30EA ribosomal protein C terminus JAB PF01398.21 VDK81553.1 - 9.4e-19 67.5 0.1 3.3e-18 65.8 0.1 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 VDK81553.1 - 6e-11 42.5 2.2 9.3e-11 41.9 2.2 1.3 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 VDK81553.1 - 1.7e-05 24.6 0.0 3.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain TACC_C PF05010.14 VDK81553.1 - 0.01 15.6 2.4 0.017 14.9 2.4 1.2 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal LIM PF00412.22 VDK81555.1 - 1.2e-11 44.6 7.7 2.3e-11 43.7 7.7 1.5 1 0 0 1 1 1 1 LIM domain LIM PF00412.22 VDK81556.1 - 4.2e-07 30.1 15.3 5.8e-07 29.7 15.3 1.2 1 0 0 1 1 1 1 LIM domain TNFR_c6 PF00020.18 VDK81556.1 - 0.055 13.9 3.6 0.055 13.9 3.6 1.9 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region PolC_DP2 PF03833.13 VDK81556.1 - 0.85 7.4 3.9 0.87 7.4 3.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Desulfoferrod_N PF06397.12 VDK81556.1 - 6.9 6.4 9.6 6.2 6.5 2.3 2.3 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Acetyltransf_18 PF18014.1 VDK81563.1 - 0.046 13.5 0.0 0.23 11.3 0.0 2.2 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain HlyIII PF03006.20 VDK81565.1 - 7.3e-68 228.6 19.1 1e-67 228.1 19.1 1.2 1 0 0 1 1 1 1 Haemolysin-III related SPW PF03779.14 VDK81565.1 - 0.057 13.0 0.3 0.057 13.0 0.3 2.5 2 0 0 2 2 2 0 SPW repeat DUF962 PF06127.11 VDK81565.1 - 2.5 8.3 6.6 0.24 11.5 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF962) PI3K_p85B PF02192.16 VDK81566.1 - 0.006 16.3 0.0 0.008 15.9 0.0 1.2 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain DUF4057 PF13266.6 VDK81566.1 - 0.084 12.6 0.1 0.1 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4057) TF_AP-2 PF03299.14 VDK81568.1 - 1.4e-70 237.3 0.3 2e-70 236.8 0.3 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 Lipoprotein_20 PF13942.6 VDK81568.1 - 0.056 13.4 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 YfhG lipoprotein OapA_N PF08525.11 VDK81576.1 - 0.45 10.5 2.9 0.65 10.0 2.9 1.3 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif zf-met PF12874.7 VDK81577.1 - 3.7e-05 24.0 7.0 0.034 14.5 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 VDK81577.1 - 4.3e-05 24.0 19.2 0.0011 19.6 1.6 3.9 3 1 1 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK81577.1 - 0.00015 22.1 0.9 0.00015 22.1 0.9 3.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf_UBZ PF18439.1 VDK81577.1 - 0.017 14.7 5.4 0.059 13.0 1.5 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 VDK81577.1 - 0.035 14.4 7.4 1.7 9.0 0.2 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK81577.1 - 0.038 14.0 10.3 0.04 13.9 0.3 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger Gag_p30 PF02093.16 VDK81577.1 - 0.097 12.2 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Gag P30 core shell protein CpXC PF14353.6 VDK81577.1 - 0.43 10.6 3.9 2.6 8.1 0.3 2.5 1 1 0 2 2 2 0 CpXC protein C1_4 PF07975.12 VDK81577.1 - 0.56 10.5 7.3 11 6.3 2.9 2.6 2 0 0 2 2 2 0 TFIIH C1-like domain zf-H2C2_2 PF13465.6 VDK81577.1 - 0.85 10.2 12.8 0.78 10.3 1.8 3.4 2 1 0 2 2 2 0 Zinc-finger double domain Zn-ribbon_8 PF09723.10 VDK81577.1 - 1.2 9.3 7.9 0.9 9.7 0.2 3.0 3 0 0 3 3 3 0 Zinc ribbon domain HypA PF01155.19 VDK81577.1 - 2.2 8.3 8.5 2 8.5 0.2 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_2 PF12756.7 VDK81577.1 - 6.8 7.1 13.4 14 6.0 2.6 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF866 PF05907.13 VDK81578.1 - 3.3e-45 153.8 0.1 5.1e-45 153.1 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) MMR_HSR1 PF01926.23 VDK81578.1 - 2.3e-16 59.9 0.1 6.2e-16 58.5 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.6 VDK81578.1 - 8.5e-11 42.4 0.2 2e-10 41.2 0.2 1.7 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal GTP-bdg_M PF16360.5 VDK81578.1 - 1.3e-06 28.9 0.2 3.7e-06 27.5 0.2 1.7 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region Dynamin_N PF00350.23 VDK81578.1 - 0.0023 18.0 0.0 0.0054 16.8 0.0 1.6 1 0 0 1 1 1 1 Dynamin family FeoB_N PF02421.18 VDK81578.1 - 0.0097 15.4 0.0 0.021 14.3 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 VDK81578.1 - 0.067 13.1 0.2 0.49 10.3 0.0 2.4 3 0 0 3 3 3 0 RsgA GTPase TatD_DNase PF01026.21 VDK81580.1 - 1.8e-21 76.7 0.0 2e-21 76.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase TatD_DNase PF01026.21 VDK81581.1 - 1.1e-22 80.7 0.0 1.2e-22 80.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase bZIP_2 PF07716.15 VDK81587.1 - 8.9e-17 60.9 42.7 3.2e-08 33.5 14.0 3.1 2 1 0 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 VDK81587.1 - 3.7e-08 33.3 38.3 1.3e-05 25.2 16.6 2.4 2 0 0 2 2 2 2 bZIP transcription factor TSC22 PF01166.18 VDK81587.1 - 2.7 8.4 15.1 5.7 7.3 6.5 2.8 2 0 0 2 2 2 0 TSC-22/dip/bun family UPF0242 PF06785.11 VDK81587.1 - 3.7 7.6 19.1 1.3 9.1 6.6 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spc24 PF08286.11 VDK81587.1 - 4.4 7.6 16.8 3.5 7.9 2.6 3.1 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 bZIP_Maf PF03131.17 VDK81587.1 - 6.1 7.4 41.3 0.37 11.3 14.9 2.6 2 0 0 2 2 2 0 bZIP Maf transcription factor Exonuc_VII_L PF02601.15 VDK81587.1 - 7.3 6.1 18.9 3.1 7.3 5.7 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit C6 PF01681.17 VDK81588.1 - 0.052 14.1 1.7 0.17 12.4 1.7 1.9 1 1 0 1 1 1 0 C6 domain Myticin-prepro PF10690.9 VDK81588.1 - 0.078 13.2 1.6 0.16 12.2 1.6 1.6 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Lectin_C PF00059.21 VDK81589.1 - 2.2e-12 47.7 0.2 2.2e-12 47.7 0.2 2.8 4 1 0 4 4 4 1 Lectin C-type domain ShK PF01549.24 VDK81589.1 - 1.8e-08 34.8 36.3 3.3e-05 24.3 3.5 4.7 5 0 0 5 5 5 3 ShK domain-like Sof1 PF04158.14 VDK81590.1 - 1.6e-29 102.0 5.2 2.5e-29 101.4 5.2 1.3 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 VDK81590.1 - 7.1e-16 58.3 14.3 0.0016 19.2 0.0 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.11 VDK81590.1 - 0.0027 17.6 0.0 0.65 9.9 0.0 3.0 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 VDK81590.1 - 0.0074 16.6 0.0 6.3 7.2 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cut12 PF11500.8 VDK81590.1 - 0.022 14.7 0.2 0.041 13.8 0.2 1.4 1 0 0 1 1 1 0 Spindle pole body formation-associated protein DUF3338 PF11819.8 VDK81590.1 - 0.027 14.5 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3338) Pkinase PF00069.25 VDK81591.1 - 1.7e-15 57.1 0.0 2e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81591.1 - 2.3e-07 30.4 0.0 2.6e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK81591.1 - 0.00016 20.6 0.0 0.00021 20.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK81591.1 - 0.018 15.0 0.0 2.2 8.1 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 VDK81591.1 - 0.033 13.4 0.0 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase Cpn60_TCP1 PF00118.24 VDK81592.1 - 4.7e-143 477.4 9.6 5.4e-143 477.2 9.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sec63 PF02889.16 VDK81594.1 - 1.5e-92 309.4 2.1 1.3e-59 201.5 0.4 3.0 2 1 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 VDK81594.1 - 1.4e-52 178.0 1.2 1.1e-26 93.7 0.7 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 VDK81594.1 - 7.5e-25 87.9 4.9 3.2e-12 46.8 0.1 3.0 3 0 0 3 3 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 VDK81594.1 - 7.4e-19 68.1 2.5 1.5e-08 35.0 0.0 4.0 3 1 0 3 3 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 VDK81594.1 - 1.4e-08 35.1 1.5 0.00051 20.3 0.1 3.8 2 1 0 2 2 2 2 AAA domain AAA PF00004.29 VDK81594.1 - 6e-05 23.5 1.2 0.96 9.9 0.7 3.6 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 VDK81594.1 - 0.00057 19.0 0.0 0.83 8.7 0.0 2.7 2 0 0 2 2 2 2 Type II/IV secretion system protein Helicase_PWI PF18149.1 VDK81594.1 - 0.0026 17.9 0.2 0.0026 17.9 0.2 2.3 2 0 0 2 2 2 1 N-terminal helicase PWI domain PhoH PF02562.16 VDK81594.1 - 0.0054 16.2 0.0 3.9 6.9 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein AAA_7 PF12775.7 VDK81594.1 - 0.015 14.8 0.3 7.6 6.0 0.0 3.6 4 0 0 4 4 4 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 VDK81594.1 - 0.016 14.9 1.1 0.53 10.0 0.0 3.8 4 0 0 4 4 4 0 IstB-like ATP binding protein Peptidase_S46 PF10459.9 VDK81594.1 - 0.29 9.7 4.4 0.47 9.0 4.4 1.2 1 0 0 1 1 1 0 Peptidase S46 AAA_23 PF13476.6 VDK81594.1 - 0.49 10.9 11.2 27 5.2 0.0 3.3 3 0 0 3 3 3 0 AAA domain Reprolysin PF01421.19 VDK81598.1 - 1.7e-46 158.7 0.0 1.7e-46 158.7 0.0 2.0 2 0 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR PF08516.12 VDK81598.1 - 2.7e-23 82.6 4.7 2.7e-23 82.6 4.7 4.4 4 1 0 4 4 4 1 ADAM cysteine-rich Disintegrin PF00200.23 VDK81598.1 - 2.3e-19 70.0 27.9 2.3e-19 70.0 27.9 4.3 5 0 0 5 5 5 1 Disintegrin Reprolysin_5 PF13688.6 VDK81598.1 - 7.4e-18 65.4 0.1 7.4e-18 65.4 0.1 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 VDK81598.1 - 2.2e-09 37.3 0.1 4e-09 36.4 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 VDK81598.1 - 2.4e-09 37.4 0.2 4.7e-09 36.4 0.2 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 VDK81598.1 - 2.6e-09 37.6 0.1 5.2e-09 36.7 0.1 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 VDK81598.1 - 0.19 11.6 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 Matrixin NAD_binding_1 PF00175.21 VDK81599.1 - 3.1e-34 117.9 0.0 5.6e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 VDK81599.1 - 7.4e-34 116.1 0.0 1.1e-33 115.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 VDK81599.1 - 5.2e-08 33.2 0.0 3.3e-07 30.6 0.0 2.0 1 1 1 2 2 2 1 Ferric reductase NAD binding domain eRF1_2 PF03464.15 VDK81601.1 - 1.4e-46 158.1 0.1 2.1e-46 157.5 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 VDK81601.1 - 3.2e-38 130.7 0.0 6.3e-38 129.7 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 VDK81601.1 - 9.8e-19 67.6 0.0 1.6e-18 66.9 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 VDK81601.1 - 1.3e-09 38.4 0.0 1.9e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 VDK81601.1 - 6.9e-09 36.1 0.1 1.2e-08 35.3 0.1 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 Syntaxin-18_N PF10496.9 VDK81602.1 - 2.9e-08 33.8 2.0 2.9e-08 33.8 2.0 2.7 2 2 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Herpes_IE2_3 PF03361.14 VDK81602.1 - 0.019 14.9 2.0 5.9 6.7 0.0 3.1 2 2 1 3 3 3 0 Herpes virus intermediate/early protein 2/3 Fungal_lectin_2 PF18647.1 VDK81602.1 - 0.062 13.8 1.1 15 6.1 0.4 2.8 2 0 0 2 2 2 0 Alpha-galactosyl-binding fungal lectin SNARE PF05739.19 VDK81602.1 - 0.089 12.8 0.8 0.27 11.3 0.8 1.9 1 0 0 1 1 1 0 SNARE domain DASH_Dad1 PF08649.10 VDK81602.1 - 0.26 11.5 2.1 0.45 10.7 0.6 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad1 DUF737 PF05300.11 VDK81602.1 - 0.68 10.3 10.9 0.39 11.0 2.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF737) DUF4208 PF13907.6 VDK81602.1 - 0.92 10.0 4.3 0.57 10.6 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4208) Sld5 PF05916.11 VDK81602.1 - 2.6 8.5 8.3 0.41 11.1 0.7 2.9 3 0 0 3 3 3 0 GINS complex protein Synaptobrevin PF00957.21 VDK81603.1 - 1.3e-34 117.9 6.1 1.4e-34 117.7 6.1 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 VDK81603.1 - 0.0024 18.0 0.2 0.0026 17.9 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF3671 PF12420.8 VDK81603.1 - 0.0094 16.0 0.5 0.013 15.6 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function LMBR1 PF04791.16 VDK81603.1 - 0.011 14.7 0.3 0.013 14.5 0.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein PRIMA1 PF16101.5 VDK81603.1 - 0.016 15.2 1.5 0.028 14.4 1.5 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RIFIN PF02009.16 VDK81603.1 - 0.021 14.7 0.9 0.025 14.5 0.9 1.0 1 0 0 1 1 1 0 Rifin Fusion_gly PF00523.18 VDK81603.1 - 0.027 12.7 1.6 0.033 12.5 1.6 1.0 1 0 0 1 1 1 0 Fusion glycoprotein F0 Orf78 PF06024.12 VDK81603.1 - 0.036 14.4 0.4 0.045 14.0 0.4 1.2 1 0 0 1 1 1 0 Orf78 (ac78) DUF3619 PF12279.8 VDK81603.1 - 0.05 13.9 0.3 0.07 13.5 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3619) Baculo_F PF12259.8 VDK81603.1 - 0.063 11.8 1.1 0.076 11.5 1.1 1.1 1 0 0 1 1 1 0 Baculovirus F protein DUF2207 PF09972.9 VDK81603.1 - 0.075 11.8 0.1 0.078 11.7 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Integrase_H2C2 PF17921.1 VDK81603.1 - 0.078 13.1 0.2 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Integrase zinc binding domain Sigma_reg_N PF13800.6 VDK81603.1 - 0.41 11.0 4.8 0.67 10.3 4.8 1.4 1 0 0 1 1 1 0 Sigma factor regulator N-terminal zf-ZPR1 PF03367.13 VDK81604.1 - 5.3e-108 357.9 6.0 1.5e-55 187.4 2.1 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain DZR PF12773.7 VDK81604.1 - 4.8 7.3 17.9 1.2 9.2 1.2 3.8 3 1 0 3 3 3 0 Double zinc ribbon ADIP PF11559.8 VDK81615.1 - 0.00026 21.1 5.4 0.00026 21.1 5.4 4.2 5 0 0 5 5 4 1 Afadin- and alpha -actinin-Binding AAA_14 PF13173.6 VDK81615.1 - 0.00041 20.4 0.2 0.0016 18.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 VDK81615.1 - 0.0013 19.1 0.0 0.0038 17.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Leu_zip PF15294.6 VDK81615.1 - 0.0027 17.3 1.4 0.0027 17.3 1.4 3.0 4 0 0 4 4 4 1 Leucine zipper RsgA_GTPase PF03193.16 VDK81615.1 - 0.0048 16.8 0.2 0.04 13.8 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 VDK81615.1 - 0.0065 16.6 0.1 0.0065 16.6 0.1 3.0 3 1 0 3 3 2 1 Helicase HerA, central domain AAA_16 PF13191.6 VDK81615.1 - 0.015 15.7 6.4 0.27 11.6 0.2 3.1 2 1 1 3 3 3 0 AAA ATPase domain SUIM_assoc PF16619.5 VDK81615.1 - 0.037 14.1 0.5 0.037 14.1 0.5 2.4 2 0 0 2 2 1 0 Unstructured region C-term to UIM in Ataxin3 Fez1 PF06818.15 VDK81615.1 - 0.044 14.2 23.8 0.041 14.3 1.2 3.5 3 0 0 3 3 3 0 Fez1 RNA_helicase PF00910.22 VDK81615.1 - 0.048 14.0 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 VDK81615.1 - 0.05 13.9 2.6 0.47 10.7 0.4 3.1 2 1 0 2 2 2 0 AAA domain MPS2 PF17060.5 VDK81615.1 - 0.29 10.4 12.6 0.029 13.6 1.9 2.7 3 0 0 3 3 3 0 Monopolar spindle protein 2 ABC_tran PF00005.27 VDK81615.1 - 0.36 11.3 0.0 0.36 11.3 0.0 3.4 5 0 0 5 5 4 0 ABC transporter Tho2 PF11262.8 VDK81615.1 - 0.44 9.7 12.9 0.75 8.9 2.1 3.1 3 0 0 3 3 3 0 Transcription factor/nuclear export subunit protein 2 DUF3972 PF13118.6 VDK81615.1 - 2.1 8.8 11.2 3.2 8.2 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) RskA PF10099.9 VDK81615.1 - 2.2 8.5 7.3 0.21 11.9 1.3 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA TSC22 PF01166.18 VDK81615.1 - 2.8 8.3 6.2 0.67 10.3 1.4 2.5 2 0 0 2 2 2 0 TSC-22/dip/bun family FapA PF03961.13 VDK81615.1 - 2.9 6.4 10.0 0.49 8.9 2.6 2.3 2 0 0 2 2 2 0 Flagellar Assembly Protein A BNIP2 PF12496.8 VDK81615.1 - 4.2 7.8 6.6 30 5.0 0.5 3.0 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Fungal_TACC PF12709.7 VDK81615.1 - 9.2 6.8 18.3 5.2 7.6 4.0 4.1 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins EspB_PE PF18625.1 VDK81616.1 - 0.12 12.8 0.1 0.21 12.1 0.1 1.4 1 0 0 1 1 1 0 ESX-1 secreted protein B PE domain FAM199X PF15814.5 VDK81617.1 - 1.1 8.2 7.7 1.2 8.1 7.7 1.0 1 0 0 1 1 1 0 Protein family FAM199X Pyridoxal_deC PF00282.19 VDK81627.1 - 1.5e-24 86.4 0.0 2.4e-24 85.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 VDK81627.1 - 4.3e-12 45.7 0.0 1.2e-11 44.2 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V SepSecS PF05889.13 VDK81627.1 - 2.1e-05 23.4 0.0 0.0001 21.1 0.0 1.9 2 0 0 2 2 2 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 VDK81627.1 - 0.00042 19.7 0.0 0.00074 18.9 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 VDK81627.1 - 0.014 13.9 0.0 0.022 13.3 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 VDK81627.1 - 0.035 13.4 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Lectin_C PF00059.21 VDK81629.1 - 1.2e-07 32.4 3.4 1.5e-07 32.1 0.1 2.8 2 0 0 2 2 2 1 Lectin C-type domain DHR-2 PF06920.13 VDK81631.1 - 1.2e-55 189.2 8.0 1.2e-55 189.2 8.0 2.2 2 1 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 VDK81631.1 - 5.5e-41 140.5 0.1 1.2e-40 139.4 0.1 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 VDK81631.1 - 4.2e-38 131.3 0.0 7.4e-38 130.4 0.0 1.4 1 0 0 1 1 1 1 DOCK N-terminus Telomere_reg-2 PF10193.9 VDK81631.1 - 0.053 14.0 0.5 0.81 10.2 0.1 3.0 2 0 0 2 2 2 0 Telomere length regulation protein SH3_2 PF07653.17 VDK81631.1 - 0.073 12.8 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain TipAS PF07739.13 VDK81631.1 - 0.12 12.9 0.1 0.52 10.9 0.1 2.1 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain RPN1_C PF18051.1 VDK81631.1 - 0.14 12.2 0.0 8.8 6.5 0.0 2.9 2 0 0 2 2 2 0 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal Oxidored_q2 PF00420.24 VDK81633.1 - 0.058 13.0 0.2 0.11 12.1 0.2 1.6 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF4692 PF15763.5 VDK81634.1 - 0.086 13.3 0.2 0.16 12.4 0.2 1.4 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Corona_S2 PF01601.16 VDK81634.1 - 0.11 10.9 5.6 0.17 10.3 5.6 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF4381 PF14316.6 VDK81634.1 - 0.2 11.9 2.2 0.37 11.0 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF3188 PF11384.8 VDK81634.1 - 3 7.6 5.6 1.3 8.7 2.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3188) DUF2046 PF09755.9 VDK81636.1 - 3e-65 220.4 37.3 6e-65 219.5 37.3 1.4 1 1 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) FAM110_C PF14160.6 VDK81636.1 - 0.53 11.4 6.3 0.29 12.2 2.8 2.4 2 0 0 2 2 2 0 Centrosome-associated C terminus DUF4094 PF13334.6 VDK81636.1 - 0.9 10.0 17.5 0.15 12.5 1.5 3.9 2 1 1 4 4 4 0 Domain of unknown function (DUF4094) AdoMet_MTase PF07757.13 VDK81652.1 - 1.9e-35 121.6 0.3 4e-35 120.5 0.3 1.6 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase RRM_1 PF00076.22 VDK81652.1 - 4.4e-13 48.8 0.0 1.9e-06 27.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MetW PF07021.12 VDK81652.1 - 0.0021 17.7 0.0 0.0053 16.4 0.0 1.6 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW T2SSM PF04612.12 VDK81652.1 - 0.065 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Methyltransf_32 PF13679.6 VDK81652.1 - 0.068 13.2 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 VDK81652.1 - 0.07 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 VDK81652.1 - 0.089 12.6 0.0 0.35 10.6 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Androgen_recep PF02166.16 VDK81652.1 - 0.21 10.4 3.1 0.088 11.6 1.0 1.4 2 0 0 2 2 2 0 Androgen receptor PSI_integrin PF17205.3 VDK81652.1 - 2.6 7.9 5.5 2.9 7.7 0.5 2.7 2 0 0 2 2 2 0 Integrin plexin domain Pkinase PF00069.25 VDK81654.1 - 1.8e-19 70.2 0.0 6.6e-19 68.3 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81654.1 - 2e-12 47.0 0.0 5.5e-11 42.2 0.0 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase N6-adenineMlase PF10237.9 VDK81655.1 - 2.2e-48 164.1 0.3 2.9e-48 163.7 0.3 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.15 VDK81655.1 - 0.13 11.9 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 AD PF09793.9 VDK81656.1 - 2.1e-18 66.2 1.0 2.9e-18 65.8 1.0 1.2 1 0 0 1 1 1 1 Anticodon-binding domain Herpes_UL79 PF03049.14 VDK81656.1 - 0.093 12.4 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 UL79 family JAB PF01398.21 VDK81658.1 - 7.5e-34 116.2 0.1 1.2e-33 115.6 0.1 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 VDK81658.1 - 2.6e-16 60.3 4.6 9.5e-16 58.5 4.6 1.9 1 1 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 VDK81658.1 - 2.1e-05 24.2 0.0 3.8e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 VDK81658.1 - 0.085 12.9 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) Ribosomal_L14 PF00238.19 VDK81659.1 - 1e-37 128.9 0.1 1.2e-37 128.7 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ras PF00071.22 VDK81660.1 - 5.6e-45 152.9 0.1 7.1e-45 152.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK81660.1 - 1e-21 77.3 0.2 1.8e-21 76.6 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK81660.1 - 1.6e-11 44.0 0.1 2e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK81660.1 - 4.4e-05 23.1 0.2 0.00014 21.4 0.2 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF1729 PF08354.10 VDK81660.1 - 0.016 14.1 0.0 0.018 14.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) DUF3873 PF12989.7 VDK81660.1 - 0.018 15.4 0.3 0.2 12.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) DUF3246 PF11596.8 VDK81661.1 - 0.0059 16.1 0.5 0.0097 15.4 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) PBP1_TM PF14812.6 VDK81661.1 - 0.013 15.8 3.1 0.031 14.7 3.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 VDK81661.1 - 0.055 13.9 6.1 0.19 12.1 6.1 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain AHH PF14412.6 VDK81661.1 - 0.076 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH RGS_DHEX PF18148.1 VDK81661.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 Regulator of G-protein signalling DHEX domain Spt5_N PF11942.8 VDK81661.1 - 0.17 12.9 3.7 0.54 11.3 3.7 1.8 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal EF-hand_7 PF13499.6 VDK81666.1 - 1.2e-10 41.6 4.6 0.00028 21.3 1.3 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 VDK81666.1 - 4.1e-08 32.5 6.1 0.79 9.8 0.0 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 VDK81666.1 - 4.7e-07 28.9 5.8 0.075 12.6 0.0 4.4 4 1 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.9 VDK81666.1 - 5e-06 26.8 2.4 0.043 14.1 0.2 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 VDK81666.1 - 3.2e-05 23.2 11.4 0.038 13.5 0.2 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 VDK81666.1 - 0.01 15.7 0.0 2.5 8.0 0.0 3.1 3 0 0 3 3 3 0 EF-hand domain pair CbtA PF09490.10 VDK81668.1 - 0.013 15.3 0.0 0.014 15.2 0.0 1.1 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) FoP_duplication PF13865.6 VDK81669.1 - 3.2e-08 34.0 3.1 3.2e-08 34.0 3.1 2.3 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 VDK81669.1 - 0.00028 20.6 0.0 0.00067 19.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP PF00230.20 VDK81670.1 - 1.1e-09 38.4 13.2 1.4e-09 38.0 13.2 1.1 1 0 0 1 1 1 1 Major intrinsic protein BCIP PF13862.6 VDK81671.1 - 5.4e-10 39.4 2.2 1.7e-08 34.5 0.0 3.3 3 0 0 3 3 3 2 p21-C-terminal region-binding protein zf-CGNR PF11706.8 VDK81676.1 - 0.41 10.5 3.8 0.48 10.3 1.9 2.1 2 0 0 2 2 2 0 CGNR zinc finger Anoct_dimer PF16178.5 VDK81677.1 - 8.3e-61 205.6 1.2 9.8e-61 205.4 1.2 1.0 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Anoctamin PF04547.12 VDK81677.1 - 7.3e-15 54.7 0.6 1.2e-14 54.1 0.6 1.3 1 0 0 1 1 1 1 Calcium-activated chloride channel Pkinase PF00069.25 VDK81690.1 - 0.05 13.0 0.0 0.057 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain LZ_Tnp_IS481 PF13011.6 VDK81690.1 - 0.17 12.4 0.0 0.23 12.0 0.0 1.2 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 Peptidase_M24 PF00557.24 VDK81691.1 - 5.6e-44 150.3 0.1 8.3e-44 149.8 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 She9_MDM33 PF05546.11 VDK81692.1 - 8.6e-05 22.4 7.1 0.00018 21.4 7.1 1.6 1 1 0 1 1 1 1 She9 / Mdm33 family KELK PF15796.5 VDK81692.1 - 0.023 15.2 6.5 0.023 15.2 6.5 3.3 2 2 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Hemerythrin PF01814.23 VDK81692.1 - 0.077 13.6 2.3 0.079 13.6 0.9 1.7 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain FTA4 PF13093.6 VDK81692.1 - 0.14 12.0 6.5 0.72 9.7 3.5 2.5 2 1 0 2 2 2 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 bZIP_1 PF00170.21 VDK81692.1 - 0.16 12.1 12.0 0.15 12.2 2.2 3.2 3 0 0 3 3 3 0 bZIP transcription factor HAUS-augmin3 PF14932.6 VDK81692.1 - 1.6 8.2 10.4 0.5 9.9 6.7 2.0 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF3450 PF11932.8 VDK81692.1 - 1.9 7.7 10.9 2.1 7.6 7.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Allexi_40kDa PF05549.11 VDK81692.1 - 2.8 7.4 10.9 0.095 12.2 1.1 2.7 2 2 1 3 3 3 0 Allexivirus 40kDa protein DUF4484 PF14831.6 VDK81692.1 - 4.7 7.2 7.5 0.35 10.9 0.8 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4484) Vinculin PF01044.19 VDK81694.1 - 0 1471.9 8.4 0 1471.7 8.4 1.0 1 0 0 1 1 1 1 Vinculin family I_LWEQ PF01608.17 VDK81694.1 - 0.0017 18.6 24.2 0.19 12.0 0.1 6.2 5 2 1 6 6 6 3 I/LWEQ domain Clusterin PF01093.17 VDK81694.1 - 0.0064 15.6 0.1 0.016 14.3 0.1 1.6 1 0 0 1 1 1 1 Clusterin Abi_C PF14355.6 VDK81694.1 - 0.027 14.6 0.2 1.7 8.8 0.0 4.1 4 1 1 5 5 5 0 Abortive infection C-terminus DUF3140 PF11338.8 VDK81694.1 - 0.17 12.3 4.6 12 6.4 0.1 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF3140) DUF883 PF05957.13 VDK81694.1 - 1.2 9.7 8.0 2.8 8.6 0.1 4.7 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) TFIID-18kDa PF02269.16 VDK81695.1 - 2.8e-32 110.6 0.2 3.6e-32 110.3 0.2 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit EF-1_beta_acid PF10587.9 VDK81695.1 - 0.0036 17.7 3.2 0.0036 17.7 3.2 2.3 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region RVT_1 PF00078.27 VDK81696.1 - 8.3e-07 28.7 0.0 0.00037 20.1 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD PF12009.8 VDK81696.1 - 7.4e-06 26.1 0.6 0.062 13.4 0.5 3.0 1 1 1 2 2 2 2 Telomerase ribonucleoprotein complex - RNA binding domain PGM_PMM_I PF02878.16 VDK81698.1 - 1.7e-18 66.6 0.1 2.3e-09 37.1 0.1 2.7 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 VDK81698.1 - 2.5e-09 37.2 0.0 6.7e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 VDK81698.1 - 5.4e-05 23.4 0.0 0.00011 22.3 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 VDK81698.1 - 0.01 16.5 0.1 0.067 13.8 0.0 2.3 2 1 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Ras PF00071.22 VDK81700.1 - 1.3e-54 184.2 0.2 4.5e-54 182.4 0.1 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 VDK81700.1 - 2.8e-22 79.2 0.0 1.4e-21 76.9 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK81700.1 - 3.6e-08 33.1 0.1 1e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family PUF PF00806.19 VDK81700.1 - 9.9e-07 28.1 0.5 1.7 8.5 0.0 6.0 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat GTP_EFTU PF00009.27 VDK81700.1 - 5.4e-06 26.1 0.3 2.7e-05 23.8 0.1 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK81700.1 - 4.6e-05 23.4 0.0 0.09 12.7 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 VDK81700.1 - 0.00022 21.3 0.0 0.00058 19.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK81700.1 - 0.032 13.7 0.1 0.11 12.1 0.1 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B S-methyl_trans PF02574.16 VDK81700.1 - 0.052 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Homocysteine S-methyltransferase Yippee-Mis18 PF03226.14 VDK81708.1 - 2.8e-12 46.7 0.5 3.7e-12 46.4 0.5 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ATPgrasp_YheCD PF14398.6 VDK81708.1 - 0.037 13.3 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 YheC/D like ATP-grasp Jas PF16135.5 VDK81708.1 - 0.054 13.7 0.6 0.054 13.7 0.6 1.6 1 1 0 1 1 1 0 TPL-binding domain in jasmonate signalling DUF4448 PF14610.6 VDK81709.1 - 0.013 15.3 0.1 0.02 14.6 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) TMEM154 PF15102.6 VDK81709.1 - 0.18 11.7 0.2 0.34 10.8 0.2 1.6 1 0 0 1 1 1 0 TMEM154 protein family Endomucin PF07010.12 VDK81709.1 - 2.1 8.2 7.0 0.74 9.7 3.4 1.6 1 1 0 1 1 1 0 Endomucin DEAD PF00270.29 VDK81710.1 - 4.4e-21 75.4 0.4 6.1e-20 71.7 0.1 2.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK81710.1 - 2.6e-13 50.3 0.0 7.1e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 VDK81710.1 - 9.7e-13 48.4 0.1 1.5e-11 44.6 0.0 2.8 2 1 0 2 2 2 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 VDK81710.1 - 0.0012 19.4 0.1 0.0034 17.9 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain Sigma70_r4 PF04545.16 VDK81710.1 - 0.0073 15.8 0.0 2.4 7.8 0.0 3.5 3 0 0 3 3 3 1 Sigma-70, region 4 SecA_DEAD PF07517.14 VDK81710.1 - 0.093 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain DUF2053 PF09767.9 VDK81711.1 - 6.8e-38 130.3 3.8 9.3e-38 129.9 3.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2053) DUF2198 PF09964.9 VDK81711.1 - 0.042 13.9 1.6 1.2 9.3 0.2 2.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) ArfGap PF01412.18 VDK81712.1 - 2e-42 144.0 0.3 7.8e-42 142.0 0.0 2.1 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf PH PF00169.29 VDK81712.1 - 2.8e-10 40.6 5.5 3.6e-05 24.2 0.1 3.0 3 0 0 3 3 3 2 PH domain Ank_2 PF12796.7 VDK81712.1 - 3.5e-09 37.1 0.2 9.1e-09 35.8 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK81712.1 - 8.6e-06 25.9 0.3 0.00011 22.5 0.3 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) PH_11 PF15413.6 VDK81712.1 - 1.3e-05 25.5 1.9 0.07 13.5 0.2 2.9 2 0 0 2 2 2 2 Pleckstrin homology domain Ank PF00023.30 VDK81712.1 - 0.00014 22.2 1.5 0.0022 18.3 0.1 2.9 3 0 0 3 3 3 1 Ankyrin repeat PH_6 PF15406.6 VDK81712.1 - 0.0015 18.8 0.5 0.0041 17.4 0.2 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Ank_4 PF13637.6 VDK81712.1 - 0.0059 17.2 0.0 1.1 9.9 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK81712.1 - 0.019 15.5 0.2 0.4 11.4 0.1 2.7 2 0 0 2 2 2 0 Ankyrin repeat PH_2 PF08458.10 VDK81712.1 - 0.061 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region COX4 PF02936.14 VDK81712.1 - 0.097 12.7 0.0 8.1 6.5 0.0 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV PH_15 PF17339.2 VDK81712.1 - 0.098 12.6 0.2 19 5.2 0.1 2.5 2 0 0 2 2 2 0 PH domain PH_13 PF16652.5 VDK81712.1 - 0.15 11.8 1.1 0.41 10.5 1.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PH_8 PF15409.6 VDK81712.1 - 0.53 10.6 4.3 22 5.4 0.1 3.1 3 0 0 3 3 3 0 Pleckstrin homology domain zf-H2C2_2 PF13465.6 VDK81725.1 - 5.8e-18 64.4 23.4 7.9e-08 32.4 0.2 4.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 VDK81725.1 - 2.3e-15 56.1 18.1 2.6e-06 27.5 0.5 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK81725.1 - 1.2e-08 35.0 21.6 0.0027 18.4 0.3 4.2 4 0 0 4 4 3 3 C2H2-type zinc finger Zf_RING PF16744.5 VDK81725.1 - 0.0068 16.5 1.7 0.31 11.2 0.1 2.8 1 1 1 2 2 2 1 KIAA1045 RING finger zf-BED PF02892.15 VDK81725.1 - 0.025 14.6 4.6 0.39 10.8 4.5 2.9 1 1 0 1 1 1 0 BED zinc finger zf-C2H2_jaz PF12171.8 VDK81725.1 - 0.036 14.3 4.7 19 5.7 0.0 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 VDK81725.1 - 0.06 13.3 10.5 1.5 8.8 0.5 3.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 VDK81725.1 - 0.071 13.1 6.9 4.3 7.4 0.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger Apc15p PF05841.11 VDK81725.1 - 1.2 10.0 7.6 16 6.3 0.0 3.8 4 0 0 4 4 4 0 Apc15p protein C1_2 PF03107.16 VDK81725.1 - 1.3 9.4 6.0 14 6.1 1.6 3.5 2 1 0 2 2 2 0 C1 domain zf-C2H2_8 PF15909.5 VDK81725.1 - 1.5 9.1 13.9 0.14 12.4 2.5 3.4 2 1 1 3 3 3 0 C2H2-type zinc ribbon CaMKII_AD PF08332.10 VDK81727.1 - 1.4e-55 186.9 0.0 3.1e-55 185.8 0.0 1.6 1 0 0 1 1 1 1 Calcium/calmodulin dependent protein kinase II association domain DUF4440 PF14534.6 VDK81727.1 - 6e-08 33.1 0.0 1.2e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 VDK81727.1 - 4.7e-06 26.9 0.0 8.3e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain Pkinase PF00069.25 VDK81728.1 - 9e-61 205.5 0.0 9.7e-51 172.6 0.0 2.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81728.1 - 7.6e-24 84.4 0.0 2.9e-19 69.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 VDK81728.1 - 0.0027 17.1 0.2 0.0057 16.0 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 VDK81728.1 - 0.0067 15.2 0.0 0.0096 14.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Nup84_Nup100 PF04121.13 VDK81733.1 - 4.5e-75 253.2 20.1 6.3e-75 252.7 20.1 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Eaf7 PF07904.13 VDK81733.1 - 2.8e-17 63.0 0.1 8.4e-17 61.5 0.1 1.8 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 Pkinase_Tyr PF07714.17 VDK81733.1 - 3.2e-16 59.4 0.1 3.6e-08 33.0 0.0 2.5 1 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 VDK81733.1 - 8.7e-09 35.1 3.4 6.3e-05 22.5 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain TrmB PF01978.19 VDK81733.1 - 0.19 11.6 1.3 2 8.3 0.1 3.3 4 0 0 4 4 4 0 Sugar-specific transcriptional regulator TrmB Atg14 PF10186.9 VDK81735.1 - 0.0018 17.4 16.1 0.0018 17.4 16.1 4.6 1 1 2 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.8 VDK81735.1 - 0.0036 17.4 12.1 0.0036 17.4 12.1 5.9 1 1 4 6 6 6 3 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 VDK81735.1 - 0.0063 17.0 21.1 0.0063 17.0 21.1 5.5 1 1 3 4 4 4 1 Apg6 coiled-coil region bZIP_1 PF00170.21 VDK81735.1 - 0.0084 16.2 5.5 0.0084 16.2 5.5 8.3 6 1 2 8 8 8 1 bZIP transcription factor zf-C2H2_assoc PF16606.5 VDK81735.1 - 0.63 10.3 3.3 1.1 9.6 2.7 1.7 1 1 0 1 1 1 0 Unstructured conserved, between two C2H2-type zinc-fingers AAA_13 PF13166.6 VDK81735.1 - 8.2 4.9 64.1 2.2 6.8 26.7 3.3 2 1 0 3 3 3 0 AAA domain zf-UBP PF02148.19 VDK81736.1 - 8.3e-18 64.5 12.0 1.2e-17 64.0 12.0 1.2 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 VDK81736.1 - 0.013 15.3 1.6 0.025 14.3 1.6 1.5 1 0 0 1 1 1 0 Variant UBP zinc finger UBA PF00627.31 VDK81738.1 - 0.0021 17.9 1.2 0.0054 16.6 1.2 1.7 1 1 0 1 1 1 1 UBA/TS-N domain DNA_pol_lambd_f PF10391.9 VDK81738.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda TFIIF_beta PF02270.15 VDK81739.1 - 7.5e-25 86.8 0.1 1.6e-24 85.8 0.1 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 VDK81739.1 - 2.6e-21 76.7 0.1 8.6e-20 71.8 0.0 2.6 2 1 0 2 2 2 1 TFIIF, beta subunit N-terminus Sec1 PF00995.23 VDK81741.1 - 7.4e-83 279.7 0.0 8.7e-83 279.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family PARP PF00644.20 VDK81743.1 - 4.7e-62 209.1 0.0 7.7e-62 208.4 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 VDK81743.1 - 3.4e-43 147.0 0.3 5.1e-43 146.4 0.3 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 VDK81743.1 - 5.6e-21 74.4 2.0 5.6e-21 74.4 2.0 2.0 2 0 0 2 2 2 1 WGR domain BORCS6 PF10157.9 VDK81743.1 - 0.015 15.5 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 WWE PF02825.20 VDK81744.1 - 5e-15 55.8 0.2 2.5e-10 40.8 0.5 2.5 2 0 0 2 2 2 2 WWE domain tRNA-synt_His PF13393.6 VDK81755.1 - 6e-34 117.7 0.0 3.1e-33 115.4 0.0 2.0 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 VDK81755.1 - 7.4e-14 51.7 0.8 1.7e-13 50.5 0.2 2.0 2 0 0 2 2 2 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 VDK81755.1 - 1.9e-09 37.5 1.1 2.9e-09 36.8 0.7 1.5 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs tRNA-synt_2 PF00152.20 VDK81755.1 - 0.00018 20.7 0.0 0.012 14.7 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 VDK81755.1 - 0.0054 16.2 0.0 0.036 13.6 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) MIF4G PF02854.19 VDK81756.1 - 3.1e-05 23.7 2.1 4.6e-05 23.2 2.1 1.2 1 0 0 1 1 1 1 MIF4G domain PAM2 PF07145.15 VDK81756.1 - 0.0038 16.8 1.1 0.0088 15.7 0.3 2.1 2 0 0 2 2 2 1 Ataxin-2 C-terminal region DZF PF07528.14 VDK81758.1 - 1.5e-51 175.4 0.1 1.5e-51 175.4 0.1 1.7 2 0 0 2 2 2 1 DZF domain zf-met PF12874.7 VDK81758.1 - 1.7e-20 72.7 19.5 5.8e-07 29.7 1.8 3.9 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK81758.1 - 2e-15 56.6 21.4 1e-05 25.7 2.9 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDK81758.1 - 4.2e-05 23.8 19.6 0.5 10.7 3.6 4.3 3 1 1 4 4 4 3 C2H2 type zinc-finger (2 copies) LAL_C2 PF18603.1 VDK81758.1 - 0.0023 18.1 1.4 0.013 15.7 1.4 2.3 1 0 0 1 1 1 1 L-amino acid ligase C-terminal domain 2 zf-C2H2_4 PF13894.6 VDK81758.1 - 0.19 12.6 11.5 4.6 8.3 0.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger DUF3449 PF11931.8 VDK81758.1 - 0.24 11.2 0.1 0.24 11.2 0.1 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3449) zf-C2H2 PF00096.26 VDK81758.1 - 0.35 11.4 18.5 3 8.5 1.8 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-DBF PF07535.12 VDK81758.1 - 0.48 10.6 17.4 3.2 7.9 3.0 3.5 3 0 0 3 3 3 0 DBF zinc finger zf-U1 PF06220.12 VDK81758.1 - 0.82 9.5 17.4 2.2 8.1 2.0 3.5 3 0 0 3 3 3 0 U1 zinc finger Ribosomal_L34e PF01199.18 VDK81760.1 - 5.6e-38 129.1 6.3 7.2e-38 128.8 6.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e Proteasome PF00227.26 VDK81761.1 - 8.5e-34 116.7 0.0 1e-33 116.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF3912 PF13051.6 VDK81761.1 - 0.12 12.7 0.2 0.41 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3912) V-ATPase_C PF03223.15 VDK81762.1 - 2.1e-54 185.4 5.1 2.5e-54 185.1 5.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C MannoseP_isomer PF01050.18 VDK81762.1 - 0.057 13.3 0.2 11 5.9 0.0 2.2 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase Csm2_III-A PF03750.13 VDK81763.1 - 0.1 13.5 0.8 0.45 11.4 0.2 2.1 1 1 1 2 2 2 0 Csm2 Type III-A DUF1168 PF06658.12 VDK81771.1 - 1.1e-32 112.7 3.4 1.1e-32 112.7 3.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) Chromo_shadow PF01393.19 VDK81772.1 - 4.8e-29 100.2 0.3 4.9e-26 90.6 0.0 2.5 2 1 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 VDK81772.1 - 1e-20 73.4 0.1 1.2e-16 60.3 0.2 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 VDK81772.1 - 0.08 12.8 0.2 0.23 11.4 0.2 1.8 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Mtf2_C PF14061.6 VDK81772.1 - 0.94 9.7 2.9 38 4.6 0.0 3.0 3 1 0 3 3 3 0 Polycomb-like MTF2 factor 2 NARP1 PF12569.8 VDK81773.1 - 5.9e-204 678.8 14.2 5.9e-204 678.8 14.2 2.1 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_8 PF13181.6 VDK81773.1 - 2.2e-16 58.6 25.2 0.00025 21.0 0.0 10.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 VDK81773.1 - 1.6e-12 46.6 28.4 4.4e-05 23.1 0.2 9.0 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 VDK81773.1 - 9.7e-12 44.1 28.6 0.0007 19.5 0.0 10.2 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK81773.1 - 2.3e-10 40.4 14.3 0.096 13.6 0.0 9.6 8 2 3 11 11 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK81773.1 - 5.7e-08 33.2 20.9 0.015 15.8 1.0 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK81773.1 - 5e-07 29.9 12.2 0.0012 19.1 0.2 6.4 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK81773.1 - 6.5e-07 28.9 0.3 9e-06 25.3 0.0 6.3 8 1 1 9 9 9 2 TPR repeat ANAPC3 PF12895.7 VDK81773.1 - 1.3e-05 25.4 19.6 0.002 18.3 0.4 6.4 5 1 2 7 7 7 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 VDK81773.1 - 2.4e-05 23.7 18.9 5.4e-05 22.6 0.8 4.2 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK81773.1 - 0.0071 16.7 13.4 14 6.3 0.0 7.7 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK81773.1 - 0.0074 16.2 5.8 0.94 9.7 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 VDK81773.1 - 0.0085 16.1 1.4 2.6 8.2 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK81773.1 - 0.029 14.5 7.9 1.5 9.0 0.5 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 VDK81773.1 - 0.04 14.6 14.5 0.49 11.1 0.0 6.4 7 1 1 8 8 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 VDK81773.1 - 0.24 11.3 2.6 11 6.1 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat EMP24_GP25L PF01105.24 VDK81773.1 - 0.24 11.3 2.8 0.12 12.3 0.3 1.7 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Fis1_TPR_C PF14853.6 VDK81773.1 - 0.43 10.7 21.4 1.3 9.2 0.2 6.4 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat Pkinase PF00069.25 VDK81774.1 - 8.1e-69 231.9 0.0 1e-68 231.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81774.1 - 5.6e-29 101.2 0.0 8.4e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK81774.1 - 4.4e-06 26.2 0.0 5.1e-05 22.7 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDK81774.1 - 7.2e-05 21.7 0.0 0.00016 20.6 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 VDK81774.1 - 0.0018 17.7 0.0 0.004 16.5 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK81774.1 - 0.012 15.6 1.9 0.14 12.0 0.4 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 VDK81774.1 - 0.036 13.6 0.0 0.07 12.6 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 VDK81774.1 - 0.047 13.3 0.1 0.37 10.4 0.0 2.2 2 0 0 2 2 2 0 RIO1 family DUF3102 PF11300.8 VDK81774.1 - 0.1 12.8 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) Bravo_FIGEY PF13882.6 VDK81775.1 - 0.053 14.9 2.1 0.098 14.0 2.1 1.5 1 0 0 1 1 1 0 Bravo-like intracellular region Spem1 PF15670.5 VDK81775.1 - 0.074 12.6 2.0 0.087 12.4 2.0 1.0 1 0 0 1 1 1 0 Spermatid maturation protein 1 PCI PF01399.27 VDK81777.1 - 5.4e-19 68.7 5.1 4.2e-18 65.8 1.2 2.6 2 1 0 2 2 2 2 PCI domain RPN6_N PF18055.1 VDK81777.1 - 9.9e-19 67.8 1.4 1.8e-18 67.0 0.2 2.1 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain BCDHK_Adom3 PF10436.9 VDK81777.1 - 0.26 11.1 1.7 0.51 10.2 0.3 2.2 2 0 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DNA_topoisoIV PF00521.20 VDK81779.1 - 6.6e-110 367.9 0.0 1.2e-109 367.0 0.0 1.4 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 VDK81779.1 - 4.5e-40 136.9 2.9 1.1e-39 135.6 2.9 1.7 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 VDK81779.1 - 1.4e-20 73.5 3.9 2.5e-20 72.7 0.2 2.3 2 0 0 2 2 2 1 DNA gyrase B Toprim PF01751.22 VDK81779.1 - 8.1e-07 29.2 0.0 2.7e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 Toprim domain WD40 PF00400.32 VDK81796.1 - 6.8e-18 64.7 0.3 1.7e-05 25.5 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat FYVE PF01363.21 VDK81796.1 - 1.4e-13 50.8 8.7 3.3e-13 49.6 8.7 1.6 1 0 0 1 1 1 1 FYVE zinc finger Nucleoporin_N PF08801.11 VDK81796.1 - 7.9e-05 21.6 0.0 0.57 8.9 0.0 3.0 2 1 1 3 3 3 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 VDK81796.1 - 0.0057 16.9 0.0 0.025 14.9 0.0 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 VDK81796.1 - 0.021 13.9 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Coatomer WD associated region CAF1 PF04857.20 VDK81797.1 - 4.9e-67 226.4 0.0 2.4e-37 128.8 0.0 2.1 1 1 1 2 2 2 2 CAF1 family ribonuclease zf-CCCH PF00642.24 VDK81797.1 - 0.019 14.9 2.2 0.04 13.8 2.2 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TRIC PF05197.13 VDK81798.1 - 6.3e-82 273.8 2.1 8.3e-82 273.4 2.1 1.2 1 0 0 1 1 1 1 TRIC channel BAR PF03114.18 VDK81800.1 - 2e-11 44.0 11.6 2.8e-11 43.5 10.9 1.5 1 1 0 1 1 1 1 BAR domain Sec5 PF15469.6 VDK81800.1 - 0.003 17.4 3.1 0.003 17.4 3.1 3.0 2 1 1 3 3 3 1 Exocyst complex component Sec5 Syntaxin-6_N PF09177.11 VDK81800.1 - 0.0084 16.6 1.4 0.0084 16.6 1.4 2.6 2 1 1 3 3 3 1 Syntaxin 6, N-terminal UPF0184 PF03670.13 VDK81800.1 - 0.017 15.5 1.2 0.099 13.0 0.2 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) Cas_DxTHG PF09455.10 VDK81800.1 - 0.32 10.5 12.0 0.45 10.0 12.0 1.2 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family APG6_N PF17675.1 VDK81800.1 - 1.4 9.4 8.0 2.7 8.5 7.7 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Methyltransf_15 PF09445.10 VDK81801.1 - 6.2e-35 120.2 0.0 1.6e-34 118.9 0.0 1.7 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 VDK81801.1 - 9.4e-06 25.5 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 VDK81801.1 - 0.0025 18.5 0.3 0.0077 16.9 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 VDK81801.1 - 0.0082 15.8 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Peptidase_S29 PF02907.15 VDK81803.1 - 0.14 11.9 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease AAA PF00004.29 VDK81805.1 - 2.1e-43 147.9 0.0 3.8e-43 147.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK81805.1 - 1.5e-12 47.1 0.2 4.1e-12 45.7 0.2 1.8 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 VDK81805.1 - 4.5e-09 36.1 0.7 9.2e-09 35.1 0.0 1.8 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 VDK81805.1 - 5.2e-07 30.2 0.1 0.00014 22.3 0.0 2.9 2 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 VDK81805.1 - 5.5e-07 29.7 0.1 0.0001 22.3 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 VDK81805.1 - 4.9e-06 26.8 0.0 9.3e-05 22.6 0.0 2.5 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 VDK81805.1 - 5.2e-06 26.8 1.2 0.0029 17.9 0.0 3.1 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 VDK81805.1 - 2.8e-05 23.9 0.0 6.4e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 VDK81805.1 - 0.00031 21.3 0.2 0.0018 18.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 VDK81805.1 - 0.0012 19.0 0.0 0.0055 16.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 VDK81805.1 - 0.0023 17.5 0.0 0.0045 16.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Thymidylate_kin PF02223.17 VDK81805.1 - 0.0052 16.5 0.2 1.7 8.3 0.0 2.6 2 1 0 2 2 2 1 Thymidylate kinase Prot_ATP_OB_N PF17758.1 VDK81805.1 - 0.006 16.2 0.4 0.019 14.6 0.1 1.9 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_24 PF13479.6 VDK81805.1 - 0.0072 16.1 0.0 0.024 14.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 VDK81805.1 - 0.0081 15.9 0.0 0.018 14.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 VDK81805.1 - 0.0086 15.9 0.0 0.023 14.5 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 VDK81805.1 - 0.0087 15.2 0.0 0.022 13.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TsaE PF02367.17 VDK81805.1 - 0.009 16.0 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 VDK81805.1 - 0.011 16.2 0.0 0.022 15.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 VDK81805.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_11 PF13086.6 VDK81805.1 - 0.016 15.0 1.6 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 VDK81805.1 - 0.018 14.2 0.0 0.039 13.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 VDK81805.1 - 0.022 14.8 0.0 0.048 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 VDK81805.1 - 0.025 14.5 0.1 0.65 9.9 0.0 2.8 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea SKI PF01202.22 VDK81805.1 - 0.079 13.1 1.8 1.4 9.1 0.0 2.8 2 1 1 3 3 3 0 Shikimate kinase NACHT PF05729.12 VDK81805.1 - 0.086 12.7 0.0 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 VDK81805.1 - 0.1 12.9 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain DivIC PF04977.15 VDK81805.1 - 0.1 12.3 1.2 0.34 10.7 1.2 1.8 1 0 0 1 1 1 0 Septum formation initiator AAA_25 PF13481.6 VDK81805.1 - 0.14 11.8 0.0 0.41 10.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain Tau95 PF09734.9 VDK81806.1 - 2.3e-30 106.2 0.1 4.8e-30 105.2 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 VDK81806.1 - 5.2e-16 59.0 0.1 2.2e-14 53.7 0.1 2.5 1 1 0 1 1 1 1 Tau95 Triple barrel domain Acetyltransf_1 PF00583.25 VDK81808.1 - 1.8e-09 37.8 0.1 2.5e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 VDK81808.1 - 3.4e-07 30.2 0.0 5.4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 VDK81808.1 - 5.7e-07 29.9 0.2 9.4e-07 29.2 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Apc13p PF05839.11 VDK81810.1 - 0.1 12.8 0.2 0.23 11.7 0.2 1.7 1 1 0 1 1 1 0 Apc13p protein LOH1CR12 PF10158.9 VDK81811.1 - 1.2e-23 83.5 0.7 1.7e-23 83.1 0.7 1.2 1 0 0 1 1 1 1 Tumour suppressor protein PUL PF08324.11 VDK81811.1 - 0.022 14.0 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 PUL domain RSS_P20 PF11757.8 VDK81811.1 - 0.09 13.2 0.5 2.1 8.8 0.0 2.5 2 1 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain CCDC53 PF10152.9 VDK81812.1 - 2.4e-26 93.0 0.2 2.8e-26 92.8 0.2 1.0 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex PDZ_2 PF13180.6 VDK81818.1 - 1.6e-13 50.8 0.0 1e-05 25.8 0.0 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK81818.1 - 2.4e-13 49.7 0.1 2.2e-06 27.4 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 VDK81818.1 - 4.1e-12 46.3 0.0 5.5e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_4 PF17816.1 VDK81818.1 - 0.0013 19.1 0.0 0.079 13.4 0.0 2.4 2 0 0 2 2 2 1 PDZ domain Leo1 PF04004.13 VDK81818.1 - 0.0053 16.6 0.3 0.038 13.8 0.2 2.1 2 0 0 2 2 2 1 Leo1-like protein Tricorn_PDZ PF14685.6 VDK81818.1 - 0.066 13.2 0.0 0.45 10.5 0.0 2.3 2 0 0 2 2 2 0 Tricorn protease PDZ domain Profilin PF00235.19 VDK81821.1 - 2.7e-32 111.7 0.0 3.1e-32 111.5 0.0 1.0 1 0 0 1 1 1 1 Profilin Skp1_POZ PF03931.15 VDK81822.1 - 3.7e-12 46.2 0.0 5.3e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain AMNp_N PF10423.9 VDK81822.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus SH3_1 PF00018.28 VDK81823.1 - 5.2e-47 157.2 4.9 1e-17 63.5 0.1 4.1 5 0 0 5 5 5 3 SH3 domain SH3_9 PF14604.6 VDK81823.1 - 2.3e-44 149.0 3.4 2.6e-17 62.4 0.2 3.7 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 VDK81823.1 - 2.9e-33 113.3 4.0 8.4e-14 51.0 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain SH2 PF00017.24 VDK81823.1 - 4.1e-19 68.5 0.0 9.6e-19 67.3 0.0 1.7 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.11 VDK81823.1 - 3.3e-12 46.5 6.0 0.00032 20.9 0.4 3.8 4 0 0 4 4 4 3 Bacterial SH3 domain SH3_10 PF17902.1 VDK81823.1 - 1.9e-06 27.8 0.2 0.044 13.9 0.0 3.1 3 0 0 3 3 3 2 SH3 domain hSH3 PF14603.6 VDK81823.1 - 0.00017 21.9 0.0 1.1 9.7 0.0 3.2 3 0 0 3 3 3 2 Helically-extended SH3 domain SH3_16 PF18348.1 VDK81823.1 - 0.00088 19.0 0.7 0.2 11.5 0.1 3.5 4 0 0 4 4 4 1 Bacterial dipeptidyl-peptidase Sh3 domain DB PF01682.19 VDK81825.1 - 3.2e-16 59.4 14.2 3.2e-16 59.4 14.2 2.1 2 0 0 2 2 2 1 DB module Patched PF02460.18 VDK81829.1 - 8.6e-204 679.0 6.8 1.1e-203 678.7 6.8 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK81829.1 - 6.9e-33 113.7 2.0 6.9e-33 113.7 2.0 3.0 4 1 0 4 4 4 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 VDK81829.1 - 7e-05 20.7 2.3 7e-05 20.7 2.3 1.9 2 0 0 2 2 2 1 AcrB/AcrD/AcrF family SecD_SecF PF02355.16 VDK81829.1 - 0.074 12.4 11.2 0.02 14.3 2.3 2.6 2 0 0 2 2 2 0 Protein export membrane protein Peptidase_S48 PF03574.15 VDK81829.1 - 0.19 11.9 0.0 0.35 11.1 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S48 APP_E2 PF12925.7 VDK81841.1 - 2.4e-65 219.8 20.2 5e-65 218.8 20.2 1.5 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein APP_N PF02177.16 VDK81841.1 - 1.2e-34 118.6 1.1 3.3e-34 117.2 0.1 2.4 2 0 0 2 2 2 1 Amyloid A4 N-terminal heparin-binding APP_Cu_bd PF12924.7 VDK81841.1 - 4.1e-21 75.5 2.9 1.4e-20 73.8 2.9 2.0 1 0 0 1 1 1 1 Copper-binding of amyloid precursor, CuBD APP_amyloid PF10515.9 VDK81841.1 - 4.5e-17 62.3 0.5 1.8e-16 60.4 0.0 2.3 2 0 0 2 2 2 1 Beta-amyloid precursor protein C-terminus DUF1140 PF06600.11 VDK81841.1 - 0.28 11.6 6.9 0.9 10.0 6.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1140) OmpH PF03938.14 VDK81841.1 - 0.86 9.9 15.3 2.4 8.5 15.3 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) YlqD PF11068.8 VDK81841.1 - 0.86 10.0 11.5 2.1 8.7 11.5 1.6 1 0 0 1 1 1 0 YlqD protein CTD_bind PF04818.13 VDK81841.1 - 2.9 8.8 5.3 18 6.2 2.8 2.8 1 1 1 2 2 2 0 RNA polymerase II-binding domain. DUF898 PF05987.13 VDK81842.1 - 0.09 11.8 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Frizzled PF01534.17 VDK81842.1 - 0.12 11.4 0.7 0.17 10.9 0.0 1.5 2 0 0 2 2 2 0 Frizzled/Smoothened family membrane region RCC1 PF00415.18 VDK81843.1 - 1.1e-14 54.8 0.1 6.9e-05 23.4 0.1 3.5 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Ank_2 PF12796.7 VDK81843.1 - 0.021 15.4 0.0 0.057 14.0 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK81843.1 - 0.026 14.9 0.0 0.069 13.5 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Homeodomain PF00046.29 VDK81844.1 - 2.7e-20 71.9 7.3 5.9e-20 70.9 7.3 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK81844.1 - 0.025 14.5 0.2 0.064 13.2 0.2 1.7 1 0 0 1 1 1 0 Homeobox KN domain NOA36 PF06524.12 VDK81844.1 - 0.45 9.8 16.9 0.96 8.7 16.9 1.5 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 VDK81844.1 - 0.48 8.6 8.8 0.83 7.8 8.8 1.4 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 VDK81844.1 - 1.7 7.8 5.1 3.4 6.8 5.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 VDK81844.1 - 3.1 5.8 15.7 0.15 10.1 10.2 1.6 2 0 0 2 2 2 0 DNA polymerase phi NOG1_N PF17835.1 VDK81845.1 - 2e-50 170.9 8.6 2.5e-50 170.6 4.0 2.6 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 VDK81845.1 - 1e-25 89.2 0.2 2.8e-25 87.9 0.2 1.8 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 VDK81845.1 - 2e-21 75.7 0.6 5.5e-21 74.3 0.6 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 VDK81845.1 - 2.3e-18 66.3 0.0 6.6e-18 64.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK81845.1 - 2.7e-12 46.5 0.1 6.5e-12 45.2 0.1 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 VDK81845.1 - 2.4e-05 24.3 0.7 0.069 13.1 0.0 3.7 3 1 0 3 3 3 2 RsgA GTPase SRPRB PF09439.10 VDK81845.1 - 0.0014 18.1 0.3 0.015 14.7 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 VDK81845.1 - 0.0036 17.4 2.1 2.7 8.0 0.0 3.3 2 1 1 3 3 3 2 Dynamin family AAA_16 PF13191.6 VDK81845.1 - 0.072 13.5 0.0 0.29 11.5 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 VDK81845.1 - 0.11 12.8 0.7 1.8 8.9 0.0 3.2 2 1 1 3 3 3 0 AAA domain GvpL_GvpF PF06386.11 VDK81845.1 - 0.17 11.8 2.5 0.48 10.3 2.5 1.7 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Methyltransf_8 PF05148.15 VDK81846.1 - 5.4e-13 49.3 0.0 1e-12 48.4 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase YolD PF08863.10 VDK81846.1 - 0.016 15.3 2.1 0.03 14.4 0.1 2.2 2 0 0 2 2 2 0 YolD-like protein DUF1943 PF09172.11 VDK81846.1 - 0.11 11.7 3.2 0.13 11.5 3.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DUF4500 PF14937.6 VDK81846.1 - 0.24 11.4 0.0 0.24 11.4 0.0 2.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4500) LEM PF03020.15 VDK81856.1 - 1.4e-15 56.6 0.0 3.5e-15 55.3 0.0 1.8 1 0 0 1 1 1 1 LEM domain MSC PF09402.10 VDK81856.1 - 0.0001 21.9 0.1 0.00019 21.0 0.1 1.4 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain RRM_1 PF00076.22 VDK81856.1 - 0.00049 19.9 0.0 0.0013 18.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 VDK81857.1 - 2.3e-67 227.1 0.0 2.7e-67 226.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK81857.1 - 1.1e-31 110.1 0.0 2e-31 109.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK81857.1 - 0.00059 19.3 0.1 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 VDK81857.1 - 0.0025 17.4 0.1 0.0045 16.6 0.1 1.5 1 1 0 1 1 1 1 RIO1 family APH PF01636.23 VDK81857.1 - 0.0037 17.2 0.0 0.0091 15.9 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 VDK81857.1 - 0.0037 16.6 0.0 0.0065 15.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 VDK81857.1 - 0.034 13.1 0.1 0.048 12.6 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Clc-like PF07062.12 VDK81858.1 - 4.2e-34 117.9 18.1 1.3e-17 64.0 3.0 2.1 2 0 0 2 2 2 2 Clc-like PMP22_Claudin PF00822.20 VDK81858.1 - 0.029 14.2 12.1 0.26 11.2 0.2 2.8 1 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family Armet PF10208.9 VDK81861.1 - 9.7e-61 204.0 7.6 1.2e-60 203.7 7.6 1.0 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding UQ_con PF00179.26 VDK81862.1 - 7.6e-47 158.5 0.0 8.6e-47 158.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK81862.1 - 0.0056 16.4 0.0 0.0072 16.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 VDK81862.1 - 0.0091 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 VDK81862.1 - 0.053 13.8 0.2 0.095 13.0 0.2 1.5 1 1 0 1 1 1 0 RWD domain Bap31 PF05529.12 VDK81863.1 - 4.2e-40 136.7 4.9 6.1e-40 136.2 4.9 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 VDK81863.1 - 1.9e-14 53.4 5.7 1.9e-14 53.4 5.7 1.9 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain Macoilin PF09726.9 VDK81863.1 - 0.016 13.8 1.1 0.02 13.5 1.1 1.2 1 0 0 1 1 1 0 Macoilin family PhoLip_ATPase_N PF16209.5 VDK81863.1 - 0.056 13.1 0.1 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal Myb_DNA-bind_3 PF12776.7 VDK81863.1 - 0.22 12.6 1.8 0.24 12.4 0.3 1.8 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain OmpH PF03938.14 VDK81863.1 - 0.3 11.4 7.4 0.47 10.8 7.4 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) MCU PF04678.13 VDK81863.1 - 0.42 10.7 3.9 0.59 10.2 3.9 1.5 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Alanine_zipper PF11839.8 VDK81863.1 - 0.56 10.6 9.8 5.7 7.4 2.2 2.6 2 1 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein UPF0242 PF06785.11 VDK81863.1 - 9.4 6.3 9.4 14 5.8 9.1 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus UQ_con PF00179.26 VDK81864.1 - 2.7e-37 127.5 0.0 3.8e-37 127.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ets PF00178.22 VDK81865.1 - 1.4e-34 118.4 1.1 2.8e-34 117.4 1.1 1.5 1 0 0 1 1 1 1 Ets-domain Ldl_recept_a PF00057.18 VDK81871.1 - 7.8e-53 176.4 114.0 1.2e-10 41.4 11.2 7.1 6 0 0 6 6 6 6 Low-density lipoprotein receptor domain class A Ldl_recept_b PF00058.17 VDK81871.1 - 9.3e-13 48.4 10.8 0.0014 19.1 0.0 5.4 5 0 0 5 5 5 4 Low-density lipoprotein receptor repeat class B cEGF PF12662.7 VDK81871.1 - 0.00022 21.1 0.6 0.00022 21.1 0.6 5.2 4 0 0 4 4 4 1 Complement Clr-like EGF-like DFRP_C PF16543.5 VDK81874.1 - 2e-20 73.0 7.5 2e-20 73.0 7.5 3.6 4 1 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 VDK81874.1 - 1.1e-09 39.0 10.0 1.6e-07 32.0 1.1 3.7 2 1 1 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 VDK81874.1 - 4e-06 26.7 17.8 1.6e-05 24.8 6.3 3.1 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 VDK81874.1 - 3.9e-05 23.3 10.3 0.00014 21.5 2.0 3.2 3 0 0 3 3 3 1 CCCH-type zinc finger zf-CCCH PF00642.24 VDK81874.1 - 0.00041 20.2 1.3 0.00041 20.2 1.3 2.7 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 VDK81874.1 - 0.0007 19.8 0.6 0.2 11.9 0.2 2.8 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 VDK81874.1 - 0.046 14.2 10.3 2.8 8.5 4.5 2.8 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger VAD1-2 PF15310.6 VDK81874.1 - 3.9 7.3 9.2 0.2 11.5 3.1 1.9 2 0 0 2 2 2 0 Vitamin A-deficiency (VAD) rat model signalling NPF PF16601.5 VDK81875.1 - 0.065 13.7 0.0 0.079 13.4 0.0 1.1 1 0 0 1 1 1 0 Rabosyn-5 repeating NPF sequence-motif Got1 PF04178.12 VDK81875.1 - 0.07 13.6 4.9 0.1 13.1 4.6 1.4 1 1 0 1 1 1 0 Got1/Sft2-like family Peptidase_S28 PF05577.12 VDK81876.1 - 1e-55 189.3 0.0 1.2e-55 189.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 VDK81876.1 - 2.1e-05 24.3 0.0 6.6e-05 22.7 0.0 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 VDK81876.1 - 0.0024 17.4 0.0 0.0093 15.5 0.0 1.8 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 VDK81876.1 - 0.0083 15.4 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S37 PF05576.11 VDK81876.1 - 0.022 13.5 0.0 0.029 13.0 0.0 1.1 1 0 0 1 1 1 0 PS-10 peptidase S37 DUF2920 PF11144.8 VDK81876.1 - 0.18 10.9 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Peptidase_S28 PF05577.12 VDK81877.1 - 2.3e-45 155.2 0.0 2.6e-45 155.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Ras PF00071.22 VDK81878.1 - 7.8e-21 74.3 0.0 1.2e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 Ras family Arf PF00025.21 VDK81878.1 - 1.3e-06 28.0 0.1 2.9e-06 26.8 0.1 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK81878.1 - 8.9e-06 25.9 0.0 1.9e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 VDK81878.1 - 0.0001 22.3 0.0 0.001 19.1 0.0 2.3 1 1 1 2 2 2 1 50S ribosome-binding GTPase DUF3439 PF11921.8 VDK81878.1 - 0.21 11.5 5.5 0.46 10.5 5.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4680 PF15730.5 VDK81879.1 - 0.76 10.1 4.5 0.45 10.9 0.1 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4680) Peptidase_U4 PF03419.13 VDK81885.1 - 0.24 10.6 1.6 0.67 9.2 1.6 1.8 1 1 0 1 1 1 0 Sporulation factor SpoIIGA Ion_trans_2 PF07885.16 VDK81886.1 - 9.6e-22 76.8 36.1 1.9e-11 43.7 0.8 4.1 4 0 0 4 4 4 2 Ion channel fn3 PF00041.21 VDK81886.1 - 1.8e-17 63.4 0.2 9.7e-10 38.7 0.1 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK81886.1 - 0.0064 17.0 0.6 4.7 7.8 0.1 2.6 2 0 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 VDK81886.1 - 0.052 13.9 0.3 0.99 9.8 0.0 2.5 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III TUDOR PF00567.24 VDK81887.1 - 4.8e-17 62.1 3.0 4.6e-08 33.1 0.0 3.8 4 0 0 4 4 4 3 Tudor domain zf-CCHC PF00098.23 VDK81887.1 - 0.12 12.5 6.8 0.12 12.5 0.6 3.0 2 0 0 2 2 2 0 Zinc knuckle bZIP_2 PF07716.15 VDK81888.1 - 6.1e-14 51.8 13.8 1.1e-13 51.0 13.8 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 VDK81888.1 - 0.00034 20.6 10.0 0.00034 20.6 10.0 1.6 1 1 0 1 1 1 1 bZIP transcription factor Macoilin PF09726.9 VDK81888.1 - 0.0014 17.3 10.9 0.0018 16.9 10.9 1.1 1 0 0 1 1 1 1 Macoilin family AF-4 PF05110.13 VDK81888.1 - 0.01 14.0 23.9 0.013 13.7 23.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein bZIP_Maf PF03131.17 VDK81888.1 - 0.011 16.3 6.1 0.011 16.3 6.1 2.2 2 0 0 2 2 2 0 bZIP Maf transcription factor Period_C PF12114.8 VDK81888.1 - 0.018 14.7 12.2 0.018 14.7 12.2 1.7 2 1 0 2 2 2 0 Period protein 2/3C-terminal region FAM76 PF16046.5 VDK81888.1 - 0.06 12.7 10.1 0.073 12.4 10.1 1.0 1 0 0 1 1 1 0 FAM76 protein RAP1 PF07218.11 VDK81888.1 - 0.11 10.8 9.2 0.14 10.4 9.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF3740 PF12548.8 VDK81888.1 - 1.1 9.7 11.6 3.5 8.1 9.6 2.3 1 1 0 1 1 1 0 Sulfatase protein Pheromone PF08015.11 VDK81888.1 - 4.1 8.5 19.5 6.4 7.9 12.4 2.5 2 0 0 2 2 2 0 Fungal mating-type pheromone Uso1_p115_C PF04871.13 VDK81888.1 - 5.7 7.3 11.7 0.56 10.6 4.8 2.3 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Nop53 PF07767.11 VDK81890.1 - 2.9e-62 211.4 20.7 2.9e-62 211.4 20.7 1.5 2 0 0 2 2 2 1 Nop53 (60S ribosomal biogenesis) SET PF00856.28 VDK81903.1 - 3.6e-17 63.2 0.1 1.2e-16 61.6 0.1 1.8 1 1 0 1 1 1 1 SET domain Pre-SET PF05033.16 VDK81903.1 - 1e-05 26.1 9.3 2.1e-05 25.1 9.3 1.5 1 0 0 1 1 1 1 Pre-SET motif EF-hand_1 PF00036.32 VDK81903.1 - 4.4e-05 22.7 0.6 0.0075 15.7 0.3 2.7 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 VDK81903.1 - 0.00024 20.8 0.5 0.085 12.8 0.2 2.8 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 VDK81903.1 - 0.0011 18.3 0.9 0.38 10.3 0.7 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 VDK81903.1 - 0.0019 18.6 0.4 0.43 11.1 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 VDK81903.1 - 0.0022 17.8 0.5 2.3 8.1 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair FPN1 PF06963.12 VDK81903.1 - 0.09 11.3 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) SH3_1 PF00018.28 VDK81904.1 - 3.7e-15 55.3 0.1 5.9e-15 54.6 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK81904.1 - 5.9e-12 45.2 0.1 1e-11 44.5 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH2 PF00017.24 VDK81904.1 - 1.2e-11 44.5 0.0 2.3e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 SH2 domain SH3_2 PF07653.17 VDK81904.1 - 2.2e-08 33.6 0.0 4.1e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain hSH3 PF14603.6 VDK81904.1 - 0.0057 17.1 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 Helically-extended SH3 domain GLTSCR1 PF15249.6 VDK81905.1 - 9.3e-20 71.0 1.1 9.3e-20 71.0 1.1 3.7 4 0 0 4 4 4 1 Conserved region of unknown function on GLTSCR protein LSM PF01423.22 VDK81906.1 - 0.00046 19.8 0.2 0.0074 16.0 0.1 2.9 2 1 0 2 2 2 1 LSM domain Xpo1 PF08389.12 VDK81907.1 - 1.3e-15 57.7 9.4 3e-09 37.1 0.1 4.2 3 1 1 4 4 4 2 Exportin 1-like protein zf-RING_4 PF14570.6 VDK81908.1 - 3.4e-15 55.6 9.9 8.5e-15 54.3 9.9 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 VDK81908.1 - 4.8e-06 26.3 0.0 1.1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 VDK81908.1 - 0.00025 20.9 4.9 0.00052 19.8 4.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF4609 PF15382.6 VDK81908.1 - 0.023 14.6 3.1 0.025 14.4 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4609) Nup35_RRM_2 PF14605.6 VDK81908.1 - 0.032 14.2 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif zf-RING_2 PF13639.6 VDK81908.1 - 0.074 13.4 7.2 0.21 11.9 7.2 1.9 1 0 0 1 1 1 0 Ring finger domain zf-CCCH_2 PF14608.6 VDK81908.1 - 0.078 13.5 1.5 0.27 11.8 1.5 2.0 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger RBM39linker PF15519.6 VDK81908.1 - 0.092 13.8 0.2 0.54 11.4 0.0 2.4 2 0 0 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein zf-C3HC4_2 PF13923.6 VDK81908.1 - 2.5 8.0 7.1 6.1 6.8 7.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MRP-S24 PF14955.6 VDK81909.1 - 9.5e-48 161.6 0.1 1.1e-47 161.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S24 zf-C3HC PF07967.13 VDK81910.1 - 1.4e-19 70.5 1.0 1.4e-19 70.5 1.0 3.2 3 1 0 3 3 3 1 C3HC zinc finger-like Sgf11 PF08209.11 VDK81910.1 - 0.012 15.2 1.0 5 6.8 0.1 2.8 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) BIR PF00653.21 VDK81910.1 - 0.012 16.3 4.9 0.034 14.8 2.2 3.2 4 0 0 4 4 4 0 Inhibitor of Apoptosis domain Rsm1 PF08600.10 VDK81910.1 - 0.021 15.0 14.6 0.032 14.4 3.9 3.6 2 2 0 2 2 2 0 Rsm1-like Kdo_hydroxy PF11004.8 VDK81910.1 - 0.12 11.6 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase zf_C2H2_6 PF18450.1 VDK81910.1 - 0.38 10.5 4.7 12 5.7 0.4 2.9 2 0 0 2 2 2 0 Zinc Finger domain Metallophos PF00149.28 VDK81914.1 - 2.1e-24 87.2 1.8 3.7e-24 86.4 1.8 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PADR1 PF08063.12 VDK81914.1 - 0.07 12.9 1.8 0.21 11.4 0.0 2.4 2 0 0 2 2 2 0 PADR1 (NUC008) domain RGM_C PF06534.13 VDK81915.1 - 3.9e-39 133.9 0.3 5.3e-39 133.5 0.3 1.2 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus RGM_N PF06535.12 VDK81915.1 - 9.2e-32 110.5 0.3 1.7e-31 109.7 0.3 1.4 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus Hemocyanin_M PF00372.19 VDK81915.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 Hemocyanin, copper containing domain zf-RING_2 PF13639.6 VDK81916.1 - 8.3e-08 32.4 16.8 6.2e-07 29.7 11.4 2.3 2 0 0 2 2 2 1 Ring finger domain PRP21_like_P PF12230.8 VDK81916.1 - 4.8e-05 23.3 0.0 5.2e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein zf-RING_11 PF17123.5 VDK81916.1 - 4.9e-05 23.0 8.3 4.9e-05 23.0 8.3 2.1 2 0 0 2 2 2 1 RING-like zinc finger RNF220 PF15926.5 VDK81916.1 - 0.0074 15.9 1.0 0.0094 15.6 1.0 1.4 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.6 VDK81916.1 - 0.056 13.3 15.5 0.33 10.8 11.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-WRNIP1_ubi PF18279.1 VDK81916.1 - 0.089 13.5 0.1 0.089 13.5 0.1 3.0 3 0 0 3 3 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf_UBZ PF18439.1 VDK81916.1 - 0.12 11.9 0.2 0.12 11.9 0.2 1.8 2 0 0 2 2 1 0 Ubiquitin-Binding Zinc Finger zf-RING_UBOX PF13445.6 VDK81916.1 - 0.22 11.6 16.8 0.19 11.8 10.7 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 VDK81916.1 - 0.25 11.2 16.3 0.73 9.7 12.4 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK81916.1 - 0.39 10.7 14.2 5.7 7.0 0.1 2.3 2 0 0 2 2 2 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 VDK81916.1 - 3.1 7.5 11.1 0.46 10.1 7.0 1.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 VDK81916.1 - 4.6 7.5 12.7 3.2 8.0 6.9 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 VDK81916.1 - 5.7 6.9 17.9 2.9 7.8 0.1 2.6 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK81916.1 - 6.3 7.2 18.6 5.7 7.3 12.1 3.0 1 1 2 3 3 3 0 RING-H2 zinc finger domain DUF5354 PF17305.2 VDK81923.1 - 2.8e-14 53.4 0.4 4.2e-14 52.8 0.4 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5354) SRP54 PF00448.22 VDK81926.1 - 7.1e-76 254.2 0.0 1.2e-75 253.5 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 VDK81926.1 - 6.7e-32 110.1 2.3 6.7e-32 110.1 2.3 4.1 2 1 2 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 VDK81926.1 - 2.5e-18 66.0 1.2 2.5e-18 66.0 1.2 2.1 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 VDK81926.1 - 8.2e-06 26.0 0.0 2.3e-05 24.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 VDK81926.1 - 0.00012 22.1 0.0 0.00038 20.5 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRPRB PF09439.10 VDK81926.1 - 0.00013 21.5 1.4 0.35 10.3 0.0 3.1 2 1 0 3 3 3 2 Signal recognition particle receptor beta subunit cobW PF02492.19 VDK81926.1 - 0.00028 20.5 0.4 0.0026 17.4 0.3 2.4 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain ResIII PF04851.15 VDK81926.1 - 0.0014 18.6 1.2 0.0088 16.1 0.2 2.5 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 VDK81926.1 - 0.0017 17.7 0.0 0.0036 16.6 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin DUF2209 PF09974.9 VDK81926.1 - 0.0027 18.0 0.2 0.0095 16.3 0.2 1.9 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2209) AAA_16 PF13191.6 VDK81926.1 - 0.004 17.6 0.0 0.0093 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 VDK81926.1 - 0.008 16.6 0.8 0.21 12.0 0.0 3.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) APS_kinase PF01583.20 VDK81926.1 - 0.012 15.6 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_31 PF13614.6 VDK81926.1 - 0.015 15.2 0.1 0.047 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 VDK81926.1 - 0.018 14.7 0.0 0.065 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 VDK81926.1 - 0.021 15.3 1.9 0.074 13.5 0.3 2.7 2 1 0 2 2 2 0 AAA domain CLP1_P PF16575.5 VDK81926.1 - 0.028 14.2 0.5 8.7 6.1 0.1 2.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 VDK81926.1 - 0.028 14.5 0.7 0.13 12.3 0.1 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase MobB PF03205.14 VDK81926.1 - 0.028 14.3 0.1 0.089 12.7 0.0 1.9 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 VDK81926.1 - 0.029 13.3 0.4 1.8 7.5 0.0 3.1 3 1 1 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Thymidylate_kin PF02223.17 VDK81926.1 - 0.051 13.2 0.1 0.16 11.6 0.1 1.8 1 0 0 1 1 1 0 Thymidylate kinase AAA_22 PF13401.6 VDK81926.1 - 0.057 13.7 0.1 0.26 11.6 0.1 2.2 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 VDK81926.1 - 0.08 12.7 0.9 0.2 11.4 0.1 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 VDK81926.1 - 0.14 12.7 0.0 0.5 10.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain 7tm_1 PF00001.21 VDK81927.1 - 9.2e-10 38.3 18.3 2.1e-09 37.1 18.3 1.7 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) LRR_8 PF13855.6 VDK81927.1 - 4.2e-09 36.0 9.1 0.0016 18.2 0.8 4.4 1 1 2 4 4 4 3 Leucine rich repeat LRR_5 PF13306.6 VDK81927.1 - 2.2e-08 34.1 0.7 0.0042 17.1 0.0 2.9 3 0 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) Recep_L_domain PF01030.24 VDK81927.1 - 0.027 14.6 0.7 0.11 12.6 0.7 2.1 1 0 0 1 1 1 0 Receptor L domain DUF4190 PF13828.6 VDK81927.1 - 0.037 13.8 0.1 0.037 13.8 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4190) LRR_4 PF12799.7 VDK81927.1 - 0.073 13.5 13.6 0.79 10.2 0.1 5.0 2 2 3 5 5 5 0 Leucine Rich repeats (2 copies) SUI1 PF01253.22 VDK81927.1 - 0.11 13.1 0.0 8.8 6.9 0.0 2.4 2 0 0 2 2 2 0 Translation initiation factor SUI1 UPF0182 PF03699.13 VDK81927.1 - 0.85 7.7 5.8 1.2 7.1 5.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) HU-CCDC81_euk_1 PF14908.6 VDK81928.1 - 0.076 13.2 0.0 13 6.0 0.0 2.3 1 1 1 2 2 2 0 CCDC81 eukaryotic HU domain 1 Memo PF01875.17 VDK81935.1 - 4.6e-79 265.4 0.0 5.2e-79 265.2 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Hypoth_Ymh PF09509.10 VDK81937.1 - 0.14 12.1 0.0 0.48 10.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) Reg_prop PF07494.11 VDK81938.1 - 0.036 14.3 0.0 0.3 11.4 0.0 2.7 1 0 0 1 1 1 0 Two component regulator propeller Glyco_tran_WbsX PF14307.6 VDK81939.1 - 1.2 8.6 8.6 0.073 12.5 2.3 2.1 2 0 0 2 2 2 0 Glycosyltransferase WbsX F-box-like PF12937.7 VDK81940.1 - 0.051 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 F-box-like Ion_trans_2 PF07885.16 VDK81941.1 - 3.5e-25 87.8 29.1 1.8e-13 50.3 1.7 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK81941.1 - 0.026 13.7 16.5 1.4 8.1 11.2 2.4 2 0 0 2 2 2 0 Ion transport protein DUF2244 PF10003.9 VDK81941.1 - 0.11 12.2 0.0 11 5.6 0.0 2.7 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) DUF4411 PF14367.6 VDK81941.1 - 0.14 12.1 1.2 0.33 10.8 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Lig_chan PF00060.26 VDK81941.1 - 0.87 9.4 2.8 1.2 9.0 0.1 2.5 2 1 0 2 2 2 0 Ligand-gated ion channel Trans_reg_C PF00486.28 VDK81943.1 - 0.026 14.6 1.5 2.8 8.1 0.2 2.3 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal BAR PF03114.18 VDK81944.1 - 9.5e-10 38.5 7.3 1.5e-09 37.9 7.3 1.2 1 0 0 1 1 1 1 BAR domain Archease PF01951.16 VDK81944.1 - 0.05 13.8 0.5 0.19 12.0 0.4 2.0 1 1 1 2 2 2 0 Archease protein family (MTH1598/TM1083) BAR_2 PF10455.9 VDK81944.1 - 0.1 11.7 8.2 0.042 13.0 5.3 1.7 2 0 0 2 2 2 0 Bin/amphiphysin/Rvs domain for vesicular trafficking HlyIII PF03006.20 VDK81957.1 - 1.9e-14 53.9 7.3 2.2e-14 53.7 7.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related QCR10 PF09796.9 VDK81957.1 - 0.0062 16.6 1.0 0.026 14.6 0.0 2.3 3 0 0 3 3 3 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) CAAD PF14159.6 VDK81957.1 - 0.41 10.5 1.8 3.8 7.4 0.1 2.2 2 0 0 2 2 2 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase Arm_2 PF04826.13 VDK81958.1 - 3.8e-10 39.7 1.7 5.9e-10 39.0 1.7 1.3 1 0 0 1 1 1 1 Armadillo-like LBP_BPI_CETP_C PF02886.17 VDK81959.1 - 0.0043 16.5 0.0 0.0096 15.4 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 VDK81959.1 - 0.011 15.4 0.2 0.039 13.6 0.1 2.0 2 0 0 2 2 2 0 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 VDK81960.1 - 3.9e-36 124.7 0.8 1e-35 123.3 0.5 1.9 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain Brix PF04427.18 VDK81960.1 - 9.5e-32 110.7 0.3 2.2e-31 109.5 0.3 1.6 1 0 0 1 1 1 1 Brix domain LBP_BPI_CETP PF01273.25 VDK81960.1 - 5.1e-11 42.5 1.9 6.1e-11 42.2 0.5 1.8 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain DUF2461 PF09365.10 VDK81960.1 - 0.012 15.5 0.2 0.056 13.4 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical protein (DUF2461) Ank_2 PF12796.7 VDK81961.1 - 3e-23 82.2 8.1 6.8e-10 39.4 0.1 3.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK81961.1 - 1.4e-20 73.4 3.4 8e-07 29.5 0.4 5.2 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK81961.1 - 2.1e-17 61.4 1.2 0.00016 21.9 0.0 5.7 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 VDK81961.1 - 2.3e-16 59.6 4.8 9.3e-05 22.6 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 VDK81961.1 - 3.1e-15 55.8 4.0 2.3e-05 24.6 0.1 5.6 5 0 0 5 5 5 4 Ankyrin repeat Death PF00531.22 VDK81961.1 - 2.6e-08 33.9 0.2 1.4e-07 31.5 0.0 2.2 2 0 0 2 2 2 1 Death domain DUF2152 PF10222.9 VDK81962.1 - 2.4e-146 488.6 0.1 2.9e-146 488.3 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2152) Porin_3 PF01459.22 VDK81964.1 - 2.7e-50 171.3 0.4 3.4e-50 171.0 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic porin DUF2255 PF10012.9 VDK81964.1 - 0.0062 16.7 0.1 0.023 14.8 0.0 1.9 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2255) SPARC_Ca_bdg PF10591.9 VDK81965.1 - 3.6e-36 123.9 2.8 3.6e-36 123.9 2.8 1.8 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region FOLN PF09289.10 VDK81965.1 - 2.3e-08 34.1 5.1 2.3e-08 34.1 5.1 2.9 3 0 0 3 3 3 1 Follistatin/Osteonectin-like EGF domain Kazal_2 PF07648.15 VDK81965.1 - 1.7e-06 28.1 16.4 1.7e-06 28.0 12.9 2.9 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain EF-hand_5 PF13202.6 VDK81965.1 - 0.0048 16.3 0.3 0.021 14.3 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 VDK81965.1 - 0.0056 16.1 0.0 0.025 14.1 0.0 2.2 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 VDK81965.1 - 0.037 14.0 0.0 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 EF-hand domain Kazal_1 PF00050.21 VDK81965.1 - 0.047 13.7 13.5 0.1 12.7 8.8 3.0 2 1 0 2 2 2 0 Kazal-type serine protease inhibitor domain Pdase_C33_assoc PF14756.6 VDK81965.1 - 0.1 12.5 3.3 0.21 11.5 3.3 1.5 1 0 0 1 1 1 0 Peptidase_C33-associated domain Innexin PF00876.18 VDK81967.1 - 2.2e-105 352.8 16.6 3.7e-99 332.3 9.9 2.0 2 0 0 2 2 2 2 Innexin NYD-SP28 PF14772.6 VDK81974.1 - 0.0015 18.6 6.7 0.0015 18.6 6.7 2.8 1 1 1 2 2 2 1 Sperm tail Filament PF00038.21 VDK81974.1 - 0.0062 16.2 14.1 0.01 15.5 14.1 1.2 1 0 0 1 1 1 1 Intermediate filament protein ENT PF03735.14 VDK81974.1 - 0.13 12.3 2.9 0.15 12.2 1.4 1.9 1 1 1 2 2 2 0 ENT domain Glyco_hydr_30_2 PF14587.6 VDK81974.1 - 0.16 11.5 1.7 0.58 9.7 0.1 2.0 2 0 0 2 2 2 0 O-Glycosyl hydrolase family 30 LMBR1 PF04791.16 VDK81974.1 - 0.2 10.5 3.8 0.23 10.3 3.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein KxDL PF10241.9 VDK81974.1 - 0.22 11.8 3.3 1.8 8.9 0.4 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein SpoOE-like PF09388.10 VDK81974.1 - 7 6.6 12.8 2.4 8.1 2.9 2.9 2 1 1 3 3 3 0 Spo0E like sporulation regulatory protein DUF775 PF05603.12 VDK81976.1 - 5.6e-54 182.7 0.2 7.3e-54 182.3 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Collagen PF01391.18 VDK81978.1 - 7.4e-23 80.1 104.7 1.1e-07 31.5 41.4 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK81978.1 - 8.1e-17 61.0 1.5 1.3e-16 60.3 1.5 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain zf-LITAF-like PF10601.9 VDK81978.1 - 0.016 15.4 0.1 0.042 14.1 0.1 1.7 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Tfb2 PF03849.14 VDK81979.1 - 2.5e-89 299.8 0.0 8.6e-89 298.0 0.0 1.7 1 1 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 VDK81979.1 - 1.7e-20 73.2 0.7 4.9e-20 71.7 0.7 1.9 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 VDK81979.1 - 0.046 13.9 0.1 0.089 12.9 0.1 1.4 1 0 0 1 1 1 0 Helicase conserved C-terminal domain CNOT11 PF10155.9 VDK81980.1 - 4.1e-36 123.9 2.3 4.1e-36 123.9 2.3 2.1 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 11 Anti-adapt_IraP PF10796.9 VDK81980.1 - 0.12 13.0 2.2 0.26 11.8 1.1 2.2 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein FAM199X PF15814.5 VDK81980.1 - 0.12 11.4 4.6 0.19 10.7 4.6 1.3 1 0 0 1 1 1 0 Protein family FAM199X Neur_chan_LBD PF02931.23 VDK81982.1 - 1.2e-05 24.9 4.4 1.5e-05 24.5 4.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF900 PF05990.12 VDK81982.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) RRM_1 PF00076.22 VDK81984.1 - 2e-23 82.0 0.0 8.5e-11 41.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPOC PF07744.13 VDK81984.1 - 1.8e-12 47.4 0.0 2.7e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 SPOC domain RRM_3 PF08777.11 VDK81984.1 - 1.2e-06 28.5 0.0 0.0034 17.4 0.0 3.4 3 0 0 3 3 3 1 RNA binding motif RRM_7 PF16367.5 VDK81984.1 - 4.9e-06 26.6 0.0 0.00075 19.6 0.0 3.5 3 1 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 VDK81984.1 - 0.0039 17.2 0.0 1.5 8.9 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF2283 PF10049.9 VDK81984.1 - 0.032 14.5 0.0 0.11 12.7 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2283) Homeodomain PF00046.29 VDK81986.1 - 2.1e-22 78.7 2.5 1.3e-21 76.2 1.7 2.3 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 VDK81986.1 - 0.00013 21.8 0.1 0.0017 18.3 0.0 2.4 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 VDK81986.1 - 0.098 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Fez1 PF06818.15 VDK81994.1 - 9.7e-10 39.2 14.7 1.6e-09 38.5 13.6 1.9 1 1 0 1 1 1 1 Fez1 Macoilin PF09726.9 VDK81994.1 - 0.011 14.3 25.0 0.063 11.8 18.3 2.4 1 1 1 2 2 2 0 Macoilin family DUF2353 PF09789.9 VDK81994.1 - 0.017 14.5 12.4 0.012 15.0 10.1 1.9 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) GrpE PF01025.19 VDK81994.1 - 0.017 14.8 0.1 0.017 14.8 0.1 3.1 2 1 1 3 3 3 0 GrpE DUF4201 PF13870.6 VDK81994.1 - 0.017 14.9 13.6 0.074 12.8 8.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Rootletin PF15035.6 VDK81994.1 - 0.045 13.8 14.8 0.069 13.2 5.9 2.6 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Hydantoinase_B PF02538.14 VDK81994.1 - 0.047 12.1 1.0 0.076 11.4 1.0 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase GOLGA2L5 PF15070.6 VDK81994.1 - 0.11 11.2 12.6 0.77 8.3 9.2 2.3 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Jnk-SapK_ap_N PF09744.9 VDK81994.1 - 0.75 10.0 21.6 0.59 10.3 13.2 2.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Filament PF00038.21 VDK81994.1 - 0.84 9.2 19.1 0.28 10.7 12.0 2.7 2 1 1 3 3 3 0 Intermediate filament protein Cnn_1N PF07989.11 VDK81994.1 - 0.92 9.7 13.3 8.4 6.6 6.0 3.0 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Tho2 PF11262.8 VDK81994.1 - 1.4 8.1 6.9 1.6 7.9 2.2 2.2 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 TPR_MLP1_2 PF07926.12 VDK81994.1 - 2.1 8.4 24.8 0.068 13.2 1.6 3.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 VDK81994.1 - 2.2 7.1 20.7 0.029 13.3 8.4 2.6 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF4140 PF13600.6 VDK81994.1 - 2.9 8.4 8.3 35 4.9 0.1 3.2 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FapA PF03961.13 VDK81994.1 - 3.3 6.2 10.8 0.43 9.1 4.1 2.1 1 1 0 2 2 2 0 Flagellar Assembly Protein A DUF1640 PF07798.11 VDK81994.1 - 3.8 7.5 15.0 0.82 9.7 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Cluap1 PF10234.9 VDK81994.1 - 4.7 6.5 14.0 0.026 14.0 4.3 2.2 3 0 0 3 3 3 0 Clusterin-associated protein-1 LBP_BPI_CETP_C PF02886.17 VDK81995.1 - 1.9e-19 70.1 0.0 1.1e-11 44.7 0.0 2.3 2 0 0 2 2 2 2 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 VDK81995.1 - 4.4e-06 26.4 0.0 8.9e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain Tetraspanin PF00335.20 VDK81996.1 - 1.6e-41 142.5 13.0 1.8e-41 142.3 13.0 1.0 1 0 0 1 1 1 1 Tetraspanin family DUF817 PF05675.12 VDK81996.1 - 0.006 16.3 0.2 0.006 16.3 0.2 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF817) DUF3566 PF12089.8 VDK81996.1 - 0.23 11.8 5.7 0.25 11.7 0.7 2.7 3 0 0 3 3 3 0 Transmembrane domain of unknown function (DUF3566) Baculo_11_kDa PF06143.11 VDK81996.1 - 1.2 8.8 0.0 1.2 8.8 0.0 2.9 3 0 0 3 3 3 0 Baculovirus 11 kDa family Neurensin PF14927.6 VDK81996.1 - 7.9 6.2 9.9 1.7 8.4 4.8 2.3 2 1 0 2 2 2 0 Neurensin Filamin PF00630.19 VDK81997.1 - 8.5e-68 225.7 0.8 1e-17 64.8 0.0 7.2 7 0 0 7 7 7 7 Filamin/ABP280 repeat Y_Y_Y PF07495.13 VDK81997.1 - 4.2e-09 36.2 1.4 0.7 9.9 0.0 6.3 7 0 0 7 7 7 2 Y_Y_Y domain YtkA PF13115.6 VDK81997.1 - 0.00043 20.8 0.9 64 4.3 0.0 5.8 5 0 0 5 5 5 0 YtkA-like DUF5060 PF16586.5 VDK81997.1 - 0.00068 20.0 0.0 21 5.6 0.1 5.6 7 0 0 7 7 7 0 Domain of unknown function (DUF5060) Big_3_5 PF16640.5 VDK81997.1 - 0.0026 17.9 0.0 4.1 7.6 0.0 4.5 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 3) DUF2125 PF09898.9 VDK81997.1 - 0.0092 15.7 0.0 7.1 6.2 0.0 3.9 4 0 0 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2125) EMP24_GP25L PF01105.24 VDK81997.1 - 0.12 12.3 0.1 30 4.5 0.0 3.6 3 1 1 4 4 4 0 emp24/gp25L/p24 family/GOLD CopC PF04234.12 VDK81997.1 - 0.15 13.1 0.1 12 7.0 0.0 3.7 4 0 0 4 4 4 0 CopC domain FixH PF05751.11 VDK81997.1 - 0.2 11.7 0.5 3.2 7.8 0.0 3.3 6 0 0 6 6 6 0 FixH DUF4364 PF14277.6 VDK81997.1 - 0.23 11.2 0.1 1.8 8.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4364) PX PF00787.24 VDK82004.1 - 1.8e-09 37.5 0.3 3.6e-09 36.6 0.3 1.5 1 0 0 1 1 1 1 PX domain Helicase_C_4 PF13871.6 VDK82004.1 - 0.0071 16.1 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue Complex1_49kDa PF00346.19 VDK82005.1 - 7e-119 395.9 0.0 9.1e-119 395.5 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 VDK82005.1 - 2.4e-05 23.4 0.0 4.6e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Nickel-dependent hydrogenase FANCI_S3 PF14677.6 VDK82006.1 - 0.013 15.2 0.2 0.029 14.1 0.0 1.7 2 0 0 2 2 2 0 FANCI solenoid 3 Ground-like PF04155.18 VDK82007.1 - 8.4e-15 55.2 2.4 2.1e-14 53.9 2.4 1.7 1 0 0 1 1 1 1 Ground-like domain YycC PF14174.6 VDK82007.1 - 1.6 8.6 4.5 25 4.8 0.7 2.5 2 0 0 2 2 2 0 YycC-like protein MFS_1 PF07690.16 VDK82009.1 - 7.6e-19 67.8 20.3 7.6e-19 67.8 20.3 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily 2OG-FeII_Oxy_3 PF13640.6 VDK82013.1 - 1.4e-18 67.6 0.0 3e-18 66.5 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 VDK82013.1 - 9e-10 39.1 0.0 2e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Patched PF02460.18 VDK82020.1 - 2.8e-168 561.6 19.9 7.7e-85 285.6 3.6 3.0 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK82020.1 - 1.4e-25 89.9 4.8 1.4e-25 89.9 4.8 3.0 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 VDK82020.1 - 7.2e-06 24.0 3.1 1.5e-05 23.0 3.1 1.4 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family MMPL PF03176.15 VDK82020.1 - 0.0017 17.4 0.5 0.0017 17.4 0.5 2.8 2 1 0 2 2 2 1 MMPL family GTP_EFTU PF00009.27 VDK82021.1 - 2.2e-44 151.3 0.0 3.6e-44 150.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 VDK82021.1 - 3.2e-14 53.2 0.1 9.9e-14 51.6 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 VDK82021.1 - 2.6e-08 33.9 0.0 0.0022 18.1 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK82021.1 - 0.032 13.8 0.1 14 5.1 0.0 2.9 2 1 1 3 3 3 0 Ferrous iron transport protein B DUF4061 PF13270.6 VDK82023.1 - 1.9e-05 24.9 1.5 3.9e-05 23.9 1.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4061) CLTH PF10607.9 VDK82025.1 - 3.6e-22 78.9 0.1 5.9e-22 78.1 0.1 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 VDK82025.1 - 0.0012 18.7 0.0 0.0032 17.4 0.0 1.7 1 0 0 1 1 1 1 LisH Yos1 PF08571.10 VDK82026.1 - 7e-26 90.3 1.7 7.7e-26 90.2 1.7 1.0 1 0 0 1 1 1 1 Yos1-like DUF1472 PF07339.12 VDK82026.1 - 0.11 13.0 0.1 0.12 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1472) Med28 PF11594.8 VDK82027.1 - 1.5e-16 60.7 2.9 1.8e-16 60.5 1.2 2.0 2 0 0 2 2 2 1 Mediator complex subunit 28 YtxH PF12732.7 VDK82027.1 - 0.0077 16.7 2.8 0.043 14.4 0.1 2.9 3 1 0 3 3 3 1 YtxH-like protein Flavodoxin_1 PF00258.25 VDK82027.1 - 0.15 12.3 0.3 2.7 8.2 0.1 2.4 2 0 0 2 2 2 0 Flavodoxin Med30 PF11315.8 VDK82027.1 - 0.67 10.1 7.3 2.1 8.6 0.4 3.1 3 0 0 3 3 3 0 Mediator complex subunit 30 ELFV_dehydrog PF00208.21 VDK82027.1 - 1.8 8.2 4.7 6 6.5 0.8 2.2 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DUF167 PF02594.16 VDK82028.1 - 6.5e-20 71.0 0.0 9.2e-20 70.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 PBD PF00786.28 VDK82029.1 - 0.0068 16.7 0.2 0.01 16.1 0.2 1.3 1 0 0 1 1 1 1 P21-Rho-binding domain GCV_T PF01571.21 VDK82046.1 - 1.8e-51 175.0 0.0 2.7e-51 174.4 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 VDK82046.1 - 1.5e-49 169.4 0.1 2.4e-49 168.8 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GCV_T_C PF08669.11 VDK82046.1 - 7.3e-09 35.4 0.0 3e-07 30.3 0.0 3.0 3 0 0 3 3 3 1 Glycine cleavage T-protein C-terminal barrel domain FAO_M PF16350.5 VDK82046.1 - 1.1e-06 28.8 0.6 2.3e-06 27.8 0.6 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain Pyr_redox_2 PF07992.14 VDK82046.1 - 0.11 11.7 0.5 1.3 8.2 0.1 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase TMEM208_SND2 PF05620.11 VDK82047.1 - 4.8e-37 127.3 0.5 1e-36 126.3 0.5 1.5 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 XTBD PF11952.8 VDK82047.1 - 8.2e-24 83.2 0.1 2.6e-23 81.6 0.1 1.9 1 0 0 1 1 1 1 XRN-Two Binding Domain, XTBD mit_SMPDase PF14724.6 VDK82047.1 - 0.0082 14.2 4.9 0.016 13.2 1.3 2.2 1 1 0 2 2 2 1 Mitochondrial-associated sphingomyelin phosphodiesterase MFS_1 PF07690.16 VDK82047.1 - 0.02 13.8 3.5 0.032 13.2 3.5 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily NTF2 PF02136.20 VDK82048.1 - 8.3e-28 97.4 0.0 9.7e-28 97.2 0.0 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 VDK82048.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 1 1 2 2 2 0 Nuclear pore RNA shuttling protein Mtr2 DUF4440 PF14534.6 VDK82048.1 - 0.11 13.0 0.0 0.16 12.4 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4440) DUF4518 PF15008.6 VDK82048.1 - 0.16 11.1 0.0 0.33 10.1 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4518) DUF4078 PF13300.6 VDK82050.1 - 1.8e-14 53.8 8.3 1.8e-14 53.8 8.3 2.9 2 2 1 3 3 3 1 Domain of unknown function (DUF4078) TMPIT PF07851.13 VDK82050.1 - 9.4 5.4 9.7 0.16 11.2 1.6 1.9 2 0 0 2 2 2 0 TMPIT-like protein S10_plectin PF03501.15 VDK82051.1 - 2.3e-46 155.8 0.4 3.1e-46 155.4 0.4 1.2 1 0 0 1 1 1 1 Plectin/S10 domain GPP34 PF05719.11 VDK82052.1 - 1.3e-58 198.5 0.1 1.8e-58 197.9 0.1 1.2 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) Arf PF00025.21 VDK82053.1 - 6.8e-38 129.9 0.0 8.1e-38 129.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK82053.1 - 2.2e-13 50.5 0.0 3.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK82053.1 - 1.2e-12 47.7 0.0 1.7e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 VDK82053.1 - 1.3e-11 44.3 0.0 1.7e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 VDK82053.1 - 8.7e-10 38.3 0.1 8.9e-06 25.1 0.0 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 VDK82053.1 - 1.6e-08 34.2 0.0 1.9e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK82053.1 - 1.2e-05 25.3 0.0 1.9e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Pox_A32 PF04665.12 VDK82053.1 - 0.02 14.3 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein ATP_bind_1 PF03029.17 VDK82053.1 - 0.022 14.6 0.0 1.9 8.2 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Thymidylate_kin PF02223.17 VDK82053.1 - 0.07 12.8 0.0 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 Thymidylate kinase Dynamin_N PF00350.23 VDK82053.1 - 0.089 12.8 0.0 0.38 10.8 0.0 1.9 2 0 0 2 2 2 0 Dynamin family KAP_NTPase PF07693.14 VDK82053.1 - 0.15 11.3 0.1 0.65 9.2 0.0 1.8 2 0 0 2 2 2 0 KAP family P-loop domain AAA_28 PF13521.6 VDK82053.1 - 0.17 12.1 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain UPF0004 PF00919.20 VDK82055.1 - 3.7e-20 71.8 0.0 9.5e-20 70.5 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 Radical_SAM PF04055.21 VDK82055.1 - 5.6e-15 56.1 0.1 1.7e-14 54.6 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily NUDIX PF00293.28 VDK82055.1 - 3.9e-13 49.6 2.0 8.3e-13 48.5 2.0 1.5 1 0 0 1 1 1 1 NUDIX domain RhoGAP PF00620.27 VDK82057.1 - 6.4e-24 84.5 0.0 8.2e-24 84.2 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain DEAD PF00270.29 VDK82063.1 - 1e-50 172.0 0.0 2.6e-50 170.6 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK82063.1 - 4.1e-27 94.7 0.0 3.9e-26 91.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK82063.1 - 0.00031 20.8 0.0 0.0011 19.0 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 VDK82063.1 - 0.022 14.1 0.0 0.31 10.3 0.0 2.2 2 0 0 2 2 2 0 SecA DEAD-like domain ThiI PF02568.14 VDK82063.1 - 0.097 12.2 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Ala_racemase_N PF01168.20 VDK82064.1 - 1.4e-22 80.4 0.0 1.7e-22 80.2 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain TPT PF03151.16 VDK82065.1 - 2.5e-19 69.7 19.4 3.1e-19 69.4 19.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 VDK82065.1 - 0.00044 20.4 35.7 0.023 14.9 13.4 2.6 2 1 0 2 2 2 2 EamA-like transporter family YwiC PF14256.6 VDK82065.1 - 6.4 7.1 13.6 0.3 11.4 2.6 3.2 2 1 0 3 3 3 0 YwiC-like protein tRNA-synt_2b PF00587.25 VDK82066.1 - 2.2e-26 92.9 0.0 5.2e-26 91.7 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 VDK82066.1 - 0.075 13.3 1.0 7.2 6.9 0.0 2.8 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF507 PF04368.13 VDK82066.1 - 0.1 12.5 0.0 4 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF507) Pkinase PF00069.25 VDK82068.1 - 6.1e-73 245.4 0.0 9e-73 244.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK82068.1 - 7.6e-39 133.5 0.0 1.1e-38 133.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK82068.1 - 3.8e-07 29.7 0.0 7.8e-07 28.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like KA1 PF02149.19 VDK82068.1 - 5.2e-07 29.4 0.9 8.7e-07 28.6 0.1 1.8 2 0 0 2 2 2 1 Kinase associated domain 1 Kdo PF06293.14 VDK82068.1 - 3.4e-05 23.3 0.1 6.1e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 VDK82068.1 - 0.00034 20.3 0.0 0.00064 19.4 0.0 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 VDK82068.1 - 0.00063 19.7 0.0 0.0068 16.3 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 VDK82068.1 - 0.00074 19.2 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 VDK82068.1 - 0.0035 16.3 0.3 0.0075 15.3 0.3 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Homeodomain PF00046.29 VDK82069.1 - 6.8e-21 73.9 6.8 1.2e-20 73.1 6.8 1.4 1 0 0 1 1 1 1 Homeodomain LCE6A PF15858.5 VDK82069.1 - 0.89 10.3 6.5 6.7 7.5 0.2 3.3 2 1 1 3 3 3 0 Late cornified envelope protein 6A family Ank_2 PF12796.7 VDK82070.1 - 4.1e-09 36.9 0.1 1.8e-08 34.8 0.1 2.0 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDK82070.1 - 6.3e-08 32.3 1.3 0.025 15.1 0.2 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 VDK82070.1 - 1.3e-06 28.6 0.4 0.077 13.5 0.6 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 VDK82070.1 - 5.3e-05 23.7 0.7 0.42 11.3 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK82070.1 - 8.2e-05 22.8 0.6 0.049 14.0 0.1 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) CTP_transf_like PF01467.26 VDK82071.1 - 1.2e-28 100.2 0.0 1.9e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like PTSIIB_sorb PF03830.15 VDK82071.1 - 0.11 12.8 0.1 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component ABC2_membrane PF01061.24 VDK82078.1 - 1.1e-28 100.2 22.0 1.1e-28 100.2 22.0 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 VDK82078.1 - 3.5e-20 72.9 0.0 7.8e-20 71.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 VDK82078.1 - 0.0023 17.8 0.1 0.0052 16.7 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 VDK82078.1 - 0.02 15.2 0.0 0.038 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 VDK82078.1 - 0.027 14.7 0.0 0.099 12.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 VDK82078.1 - 0.074 12.8 0.2 0.21 11.4 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 VDK82078.1 - 0.1 12.2 0.1 0.32 10.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 VDK82078.1 - 0.12 12.5 0.1 0.29 11.2 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase MxiM PF11441.8 VDK82078.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Pilot protein MxiM ATP-synt_ab PF00006.25 VDK82078.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain SMC_N PF02463.19 VDK82078.1 - 1.1 8.7 5.2 0.47 9.9 0.5 2.4 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain Pkinase_Tyr PF07714.17 VDK82079.1 - 2.2e-76 256.5 0.0 3.9e-76 255.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 VDK82079.1 - 1.4e-43 149.2 0.0 3e-43 148.1 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain SH2 PF00017.24 VDK82079.1 - 2.2e-10 40.5 0.0 3.8e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 SH2 domain Kinase-like PF14531.6 VDK82079.1 - 0.031 13.6 0.0 3.1 7.0 0.0 2.3 2 0 0 2 2 2 0 Kinase-like Ammonium_transp PF00909.21 VDK82080.1 - 5.4e-69 232.8 20.0 7.3e-69 232.4 20.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family MgtE PF01769.16 VDK82083.1 - 1.1e-29 103.3 30.0 1.4e-19 70.7 5.3 4.0 2 1 1 3 3 3 2 Divalent cation transporter Ground-like PF04155.18 VDK82084.1 - 5e-16 59.1 2.4 8e-16 58.5 2.4 1.3 1 0 0 1 1 1 1 Ground-like domain DM PF00751.18 VDK82086.1 - 2.7e-19 68.8 11.6 5.2e-19 67.9 11.6 1.5 1 0 0 1 1 1 1 DM DNA binding domain Activator_LAG-3 PF11498.8 VDK82086.1 - 0.018 14.0 23.1 0.028 13.4 23.1 1.5 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF2722 PF10846.8 VDK82086.1 - 0.027 13.4 18.1 0.064 12.2 18.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) V_ATPase_I PF01496.19 VDK82086.1 - 0.034 12.1 5.1 0.018 13.0 2.5 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 VDK82086.1 - 0.11 11.2 2.2 0.14 10.9 2.2 1.2 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 VDK82086.1 - 0.12 12.4 10.1 0.19 11.7 10.1 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4834 PF16118.5 VDK82086.1 - 0.17 12.9 8.4 0.48 11.4 8.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) BRF1 PF07741.13 VDK82086.1 - 0.31 11.4 7.0 0.92 9.9 7.0 1.7 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Rpp20 PF12328.8 VDK82086.1 - 0.36 10.8 5.7 0.83 9.6 5.7 1.6 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P EOS1 PF12326.8 VDK82086.1 - 0.38 10.7 5.7 0.62 10.0 5.2 1.4 1 1 0 1 1 1 0 N-glycosylation protein RED_N PF07808.13 VDK82086.1 - 0.49 9.9 11.2 3.8 7.0 11.4 2.1 2 0 0 2 2 2 0 RED-like protein N-terminal region Band_3_cyto PF07565.13 VDK82086.1 - 0.5 10.1 10.8 0.045 13.5 5.8 1.7 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF3464 PF11947.8 VDK82086.1 - 0.63 9.8 6.2 1.2 8.9 6.2 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PepSY_TM_like_2 PF16357.5 VDK82086.1 - 0.87 9.5 3.5 2.1 8.3 3.5 1.6 1 0 0 1 1 1 0 Putative PepSY_TM-like CDC37_N PF03234.14 VDK82086.1 - 1.6 9.6 11.6 2.8 8.9 8.6 2.3 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding TERB2 PF15101.6 VDK82086.1 - 1.9 8.5 10.3 4.8 7.2 10.3 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Spt20 PF12090.8 VDK82086.1 - 2.2 7.8 30.9 0.1 12.2 23.6 2.3 3 0 0 3 3 3 0 Spt20 family ORF6N PF10543.9 VDK82089.1 - 0.14 12.4 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 ORF6N domain TFIIE_beta PF02186.15 VDK82090.1 - 3.6e-16 59.2 0.5 8.6e-16 58.0 0.1 1.9 2 0 0 2 2 2 1 TFIIE beta subunit core domain TFA2_Winged_2 PF18121.1 VDK82090.1 - 1.7e-09 37.2 0.2 5.2e-09 35.7 0.0 2.0 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 4HBT PF03061.22 VDK82091.1 - 2.5e-10 40.6 0.0 3.6e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 VDK82091.1 - 0.034 14.4 0.0 0.041 14.1 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily DUF4442 PF14539.6 VDK82091.1 - 0.047 13.8 0.1 0.062 13.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) SUI1 PF01253.22 VDK82092.1 - 1.9e-17 63.6 0.0 4.6e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 VDK82092.1 - 1.3e-12 48.2 0.2 1.1e-11 45.2 0.1 2.8 2 1 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 VDK82092.1 - 0.0041 17.1 0.0 0.031 14.3 0.0 2.3 1 1 0 1 1 1 1 PUA domain Reo_sigma1 PF01664.16 VDK82092.1 - 0.15 11.4 0.2 11 5.2 0.0 2.4 2 0 0 2 2 2 0 Reovirus viral attachment protein sigma 1 zf-SNAP50_C PF12251.8 VDK82093.1 - 3.8e-53 180.2 2.0 5.3e-53 179.7 2.0 1.2 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal SARAF PF06682.12 VDK82099.1 - 7.2e-77 259.3 0.3 9.3e-77 258.9 0.3 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis MotB_plug PF13677.6 VDK82099.1 - 0.14 11.8 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB RRM_1 PF00076.22 VDK82101.1 - 4.2e-24 84.1 0.5 4.1e-18 65.0 0.1 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Suf PF05843.14 VDK82101.1 - 6.8e-06 26.3 1.2 0.075 13.0 0.0 3.6 3 0 0 3 3 3 2 Suppressor of forked protein (Suf) RRM_3 PF08777.11 VDK82101.1 - 0.0079 16.2 0.1 0.057 13.5 0.1 2.5 1 0 0 1 1 1 1 RNA binding motif RRM_7 PF16367.5 VDK82101.1 - 0.0096 16.0 0.0 0.2 11.8 0.0 2.9 3 0 0 3 3 3 1 RNA recognition motif RRM_8 PF11835.8 VDK82101.1 - 0.018 15.3 0.0 0.047 13.9 0.0 1.6 1 0 0 1 1 1 0 RRM-like domain DUF4283 PF14111.6 VDK82101.1 - 0.018 14.6 0.0 0.29 10.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4283) MSC PF09402.10 VDK82101.1 - 0.03 13.8 1.9 0.055 12.9 1.9 1.4 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Nup35_RRM_2 PF14605.6 VDK82101.1 - 0.14 12.1 0.0 0.49 10.4 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RhoGEF PF00621.20 VDK82103.1 - 7.9e-20 71.9 0.1 1.7e-19 70.7 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain ERM PF00769.19 VDK82103.1 - 7 6.4 8.2 0.85 9.4 3.1 2.0 2 0 0 2 2 2 0 Ezrin/radixin/moesin family RhoGEF PF00621.20 VDK82108.1 - 6.8e-28 98.1 6.1 7.3e-28 98.0 2.3 2.5 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 VDK82108.1 - 9.1e-13 48.6 0.1 4.1e-05 24.0 0.0 3.2 3 0 0 3 3 3 2 PH domain FYVE PF01363.21 VDK82108.1 - 0.00083 19.4 15.7 0.0025 17.9 15.7 1.8 1 0 0 1 1 1 1 FYVE zinc finger PH_13 PF16652.5 VDK82108.1 - 0.0031 17.3 2.1 4.2 7.2 0.0 3.7 4 0 0 4 4 4 2 Pleckstrin homology domain XRN_M PF17846.1 VDK82108.1 - 0.026 13.5 0.4 0.026 13.5 0.4 1.7 2 0 0 2 2 2 0 Xrn1 helical domain OHCU_decarbox PF09349.10 VDK82108.1 - 0.067 13.7 0.1 0.3 11.6 0.1 2.1 1 0 0 1 1 1 0 OHCU decarboxylase zf-C3HC4_2 PF13923.6 VDK82108.1 - 4 7.4 12.6 32 4.5 8.9 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 VDK82108.1 - 9.1 6.5 17.6 0.019 15.2 5.4 2.8 4 0 0 4 4 4 0 FYVE-type zinc finger DUF550 PF04447.12 VDK82109.1 - 0.073 13.2 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF550) DUF2198 PF09964.9 VDK82109.1 - 0.23 11.5 1.0 0.57 10.3 0.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) TDP43_N PF18694.1 VDK82111.1 - 1.1e-22 79.6 0.0 3.4e-22 78.1 0.0 1.7 2 0 0 2 2 2 1 Transactive response DNA-binding protein N-terminal domain Solute_trans_a PF03619.16 VDK82112.1 - 6.4e-92 307.8 17.5 7.7e-92 307.6 17.5 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Ten1_2 PF15490.6 VDK82113.1 - 0.11 12.2 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit CBFB_NFYA PF02045.15 VDK82114.1 - 4.2e-27 94.5 5.0 7.8e-27 93.7 5.0 1.5 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Peptidase_M2 PF01401.18 VDK82126.1 - 7.4e-172 572.9 5.5 8.9e-172 572.6 5.5 1.1 1 0 0 1 1 1 1 Angiotensin-converting enzyme EB PF01683.18 VDK82126.1 - 7.6e-06 26.1 0.6 1.6e-05 25.1 0.6 1.4 1 0 0 1 1 1 1 EB module Trypan_PARP PF05887.11 VDK82126.1 - 0.021 14.8 1.6 1.1 9.3 0.1 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.25 VDK82127.1 - 1.5e-63 214.6 0.0 2.8e-63 213.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK82127.1 - 1.7e-36 125.8 0.0 4.2e-36 124.6 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase C1_1 PF00130.22 VDK82127.1 - 2.7e-33 113.6 30.0 8.7e-18 64.0 11.6 2.8 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C2 PF00168.30 VDK82127.1 - 1e-23 83.6 0.0 2.5e-23 82.3 0.0 1.7 1 0 0 1 1 1 1 C2 domain Pkinase_C PF00433.24 VDK82127.1 - 0.0072 17.0 0.6 0.015 16.0 0.6 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain C1_2 PF03107.16 VDK82127.1 - 0.23 11.8 16.0 0.67 10.3 3.1 3.0 2 0 0 2 2 2 0 C1 domain RNA_POL_M_15KD PF02150.16 VDK82127.1 - 0.37 10.7 10.3 0.072 13.0 0.6 3.2 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit FYVE_2 PF02318.16 VDK82127.1 - 0.47 10.7 13.3 3.9 7.7 1.7 3.8 3 0 0 3 3 3 0 FYVE-type zinc finger Zf_RING PF16744.5 VDK82127.1 - 3.6 7.7 16.5 1.8 8.8 3.0 3.1 3 0 0 3 3 3 0 KIAA1045 RING finger zf-RING-like PF08746.11 VDK82127.1 - 6.7 7.1 23.3 0.85 10.0 7.4 3.2 2 0 0 2 2 2 0 RING-like domain FolB PF02152.18 VDK82133.1 - 0.17 12.5 0.3 0.84 10.2 0.0 2.3 3 0 0 3 3 3 0 Dihydroneopterin aldolase RRM_1 PF00076.22 VDK82137.1 - 6.6e-11 41.9 0.2 7.7e-08 32.1 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 VDK82137.1 - 0.0015 18.5 0.2 0.023 14.7 0.1 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF1659 PF07872.11 VDK82137.1 - 0.16 11.6 0.0 0.34 10.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1659) ICAT PF06384.11 VDK82138.1 - 0.0095 16.2 0.1 0.09 13.0 0.0 2.6 2 0 0 2 2 2 1 Beta-catenin-interacting protein ICAT PrmA PF06325.13 VDK82139.1 - 6.6e-09 35.6 0.0 1.1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 VDK82139.1 - 4.6e-08 33.7 0.0 1.6e-07 32.0 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 VDK82139.1 - 1.2e-07 31.5 0.0 3.4e-07 30.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain PRMT5 PF05185.16 VDK82139.1 - 3.7e-06 26.9 0.0 6.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_11 PF08241.12 VDK82139.1 - 1.6e-05 25.4 0.0 7.3e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK82139.1 - 0.00029 20.7 0.0 0.0005 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PRMT5_C PF17286.2 VDK82139.1 - 0.0013 18.7 0.1 0.003 17.5 0.1 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_9 PF08003.11 VDK82139.1 - 0.0026 16.7 0.0 0.0043 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 VDK82139.1 - 0.0027 17.6 0.0 0.0054 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 VDK82139.1 - 0.0038 16.9 0.0 0.0067 16.1 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 VDK82139.1 - 0.0038 17.1 0.0 0.01 15.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK82139.1 - 0.0042 17.8 0.0 0.0085 16.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 VDK82139.1 - 0.007 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G DREV PF05219.12 VDK82139.1 - 0.012 14.7 0.0 0.081 12.0 0.0 2.1 1 1 1 2 2 2 0 DREV methyltransferase CMAS PF02353.20 VDK82139.1 - 0.036 13.3 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pyridoxal_deC PF00282.19 VDK82142.1 - 3.3e-146 486.8 0.0 3.9e-146 486.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain SepSecS PF05889.13 VDK82142.1 - 0.041 12.6 0.0 0.069 11.8 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 VDK82142.1 - 0.097 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase fn3 PF00041.21 VDK82143.1 - 1.8e-27 95.5 5.0 9.7e-06 25.8 0.0 8.4 8 0 0 8 8 8 7 Fibronectin type III domain Big_5 PF13205.6 VDK82143.1 - 0.021 15.5 0.6 7.3 7.3 0.0 3.9 5 1 0 6 6 6 0 Bacterial Ig-like domain 14-3-3 PF00244.20 VDK82151.1 - 5.8e-103 343.2 3.3 6.5e-103 343.0 3.3 1.0 1 0 0 1 1 1 1 14-3-3 protein Peptidase_C98 PF15499.6 VDK82151.1 - 0.0048 16.4 0.1 0.0077 15.7 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF573 PF04504.14 VDK82152.1 - 0.15 12.8 0.1 0.53 11.0 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function, DUF573 CPSF_A PF03178.15 VDK82154.1 - 7.9e-60 202.8 0.2 8.1e-59 199.5 0.0 2.6 3 0 0 3 3 3 1 CPSF A subunit region MMS1_N PF10433.9 VDK82154.1 - 8.8e-36 123.6 0.0 1.3e-35 123.0 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CBM_20 PF00686.19 VDK82155.1 - 2.3e-07 30.6 0.0 4.6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Starch binding domain GDPD PF03009.17 VDK82156.1 - 1.1e-15 58.0 0.0 1.6e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Nop16 PF09420.10 VDK82166.1 - 0.00033 20.8 31.4 8.1 6.4 31.4 3.1 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 Phage_Gp19 PF09355.10 VDK82166.1 - 0.0037 17.7 0.5 1.5 9.3 0.0 2.7 2 0 0 2 2 2 2 Phage protein Gp19/Gp15/Gp42 ACPS PF01648.20 VDK82167.1 - 2.7e-14 53.3 0.0 4.8e-13 49.2 0.0 2.2 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily RRM_1 PF00076.22 VDK82168.1 - 8.6e-14 51.1 0.1 3.2e-08 33.3 0.1 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 VDK82168.1 - 8.6e-05 22.7 23.0 8.6e-05 22.7 23.0 4.1 2 1 1 4 4 4 1 Transcription factor IIA, alpha/beta subunit RRM_7 PF16367.5 VDK82168.1 - 0.0077 16.3 0.1 0.27 11.4 0.0 3.0 3 1 0 3 3 3 1 RNA recognition motif Sarcoglycan_2 PF05510.13 VDK82172.1 - 3e-24 85.5 0.2 4.1e-24 85.1 0.2 1.2 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon Exog_C PF18026.1 VDK82173.1 - 0.04 14.0 0.0 0.072 13.2 0.0 1.4 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain Pkinase PF00069.25 VDK82174.1 - 3.1e-63 213.6 0.0 4.5e-63 213.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK82174.1 - 6.5e-33 114.1 0.0 9.4e-33 113.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 VDK82174.1 - 2e-09 37.7 0.8 6.2e-09 36.1 0.8 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Kinase-like PF14531.6 VDK82174.1 - 1.1e-06 28.2 0.0 1.8e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK82174.1 - 3.1e-05 22.9 0.0 5.7e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK82174.1 - 0.072 12.4 0.0 0.27 10.5 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 VDK82174.1 - 0.44 10.1 2.5 16 5.0 0.0 3.0 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Astacin PF01400.24 VDK82184.1 - 1.6e-67 226.8 0.0 3.4e-67 225.8 0.0 1.5 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 VDK82184.1 - 2.4e-13 50.4 0.2 1.1e-11 45.0 0.1 2.5 2 0 0 2 2 2 1 CUB domain Peptidase_M10 PF00413.24 VDK82184.1 - 0.0024 17.8 1.6 0.21 11.4 0.4 2.6 1 1 1 2 2 2 1 Matrixin Peptidase_M66 PF10462.9 VDK82184.1 - 0.0033 16.4 0.1 0.0053 15.7 0.1 1.2 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_3 PF13582.6 VDK82184.1 - 0.015 15.8 0.1 0.064 13.8 0.0 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 VDK82184.1 - 0.064 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 VDK82184.1 - 0.12 11.0 0.0 0.22 10.1 0.0 1.3 1 0 0 1 1 1 0 Putative peptidase family Fasciclin PF02469.22 VDK82185.1 - 4e-44 149.9 0.0 1.8e-18 67.0 0.0 5.1 4 1 0 4 4 4 4 Fasciclin domain PrmC_N PF17827.1 VDK82185.1 - 0.045 14.3 0.1 0.5 11.0 0.0 2.5 2 0 0 2 2 2 0 PrmC N-terminal domain COX7C PF02935.16 VDK82186.1 - 0.16 12.2 1.7 0.19 12.0 1.7 1.3 1 1 0 1 1 1 0 Cytochrome c oxidase subunit VIIc I-set PF07679.16 VDK82188.1 - 2.6e-38 130.0 0.0 4.1e-13 49.2 0.0 3.4 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK82188.1 - 2.7e-37 127.2 0.4 3.2e-17 62.9 0.0 3.8 4 0 0 4 4 4 3 Immunoglobulin domain ig PF00047.25 VDK82188.1 - 2e-25 88.8 0.1 5.3e-11 42.5 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 VDK82188.1 - 1.9e-21 76.2 0.0 3.3e-09 37.0 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 VDK82188.1 - 2.5e-18 66.2 2.1 3.2e-06 27.3 0.0 5.4 4 2 0 4 4 4 3 Immunoglobulin V-set domain Izumo-Ig PF16706.5 VDK82188.1 - 6e-05 23.0 0.1 1.2 9.3 0.0 3.9 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Adeno_E3_CR1 PF02440.15 VDK82188.1 - 0.00036 20.3 0.8 0.041 13.7 0.0 3.2 3 1 0 3 3 3 1 Adenovirus E3 region protein CR1 Ig_6 PF18452.1 VDK82188.1 - 0.00037 20.0 0.0 0.54 9.9 0.0 3.2 3 0 0 3 3 3 2 Immunoglobulin domain C2-set_2 PF08205.12 VDK82188.1 - 0.0023 18.0 0.1 0.18 11.9 0.0 2.9 2 1 1 3 3 3 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 VDK82188.1 - 0.024 14.9 2.9 8.3 6.7 0.1 4.5 4 2 0 4 4 4 0 T-cell surface glycoprotein CD3 delta chain DUF4611 PF15387.6 VDK82188.1 - 1.7 8.9 4.7 0.93 9.8 1.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Aconitase PF00330.20 VDK82189.1 - 1.7e-137 459.2 0.0 2.1e-137 458.9 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 VDK82189.1 - 6.6e-43 146.2 0.1 2.3e-42 144.4 0.0 1.9 2 0 0 2 2 2 1 Aconitase C-terminal domain PH PF00169.29 VDK82191.1 - 1e-10 42.1 0.0 2.7e-10 40.7 0.0 1.8 1 0 0 1 1 1 1 PH domain NdhM PF10664.9 VDK82191.1 - 0.046 14.0 1.0 19 5.6 0.1 3.5 3 0 0 3 3 3 0 Cyanobacterial and plastid NDH-1 subunit M Tyrosinase PF00264.20 VDK82198.1 - 4.8e-32 112.0 1.0 2.5e-31 109.7 1.0 1.9 1 1 0 1 1 1 1 Common central domain of tyrosinase Metallophos PF00149.28 VDK82199.1 - 2.3e-33 116.4 0.0 3.2e-33 116.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 VDK82199.1 - 0.006 16.0 0.0 0.0086 15.4 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5378) GrpE PF01025.19 VDK82200.1 - 2.5e-44 150.9 1.3 3e-44 150.6 1.3 1.2 1 0 0 1 1 1 1 GrpE Ribosomal_L16 PF00252.18 VDK82201.1 - 8e-19 68.0 0.0 1.3e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Frag1 PF10277.9 VDK82203.1 - 1.5e-28 99.9 13.7 2e-28 99.4 13.7 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family zf-LYAR PF08790.11 VDK82203.1 - 4e-10 39.4 6.3 4e-10 39.4 6.3 3.4 3 0 0 3 3 3 1 LYAR-type C2HC zinc finger NPM1-C PF16276.5 VDK82203.1 - 0.004 17.1 0.2 0.011 15.7 0.2 1.7 1 0 0 1 1 1 1 Nucleophosmin C-terminal domain TMEM192 PF14802.6 VDK82203.1 - 0.09 11.9 0.2 0.17 10.9 0.2 1.4 1 0 0 1 1 1 0 TMEM192 family zf_UBZ PF18439.1 VDK82203.1 - 0.12 12.0 2.0 0.74 9.5 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 VDK82203.1 - 0.14 12.6 2.2 0.7 10.5 0.2 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3611 PF12263.8 VDK82203.1 - 0.2 11.5 0.1 0.2 11.5 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3611) Chalcone_3 PF16036.5 VDK82203.1 - 0.29 11.2 2.1 4 7.5 0.2 2.2 2 0 0 2 2 2 0 Chalcone isomerase-like UNC-79 PF14776.6 VDK82206.1 - 3.7e-175 583.6 9.1 9.1e-175 582.3 8.1 1.9 2 0 0 2 2 2 1 Cation-channel complex subunit UNC-79 Zn_ribbon_SprT PF17283.2 VDK82206.1 - 0.75 9.8 4.2 0.77 9.7 0.6 2.7 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DUF1088 PF06469.11 VDK82211.1 - 1.5e-54 184.2 6.2 1.5e-54 184.2 6.2 1.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1088) PH_BEACH PF14844.6 VDK82211.1 - 0.0023 18.0 0.0 0.015 15.4 0.0 2.3 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH Mab-21 PF03281.14 VDK82213.1 - 4.3e-74 249.5 0.0 5.4e-74 249.2 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein Beach PF02138.18 VDK82214.1 - 2.6e-121 404.2 0.4 3.5e-121 403.8 0.4 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 VDK82214.1 - 5.9e-17 61.6 0.1 1.3e-16 60.5 0.1 1.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 VDK82214.1 - 2.3e-11 44.1 4.3 0.0037 18.1 0.3 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK82214.1 - 0.00021 21.5 0.1 0.025 14.9 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 VDK82214.1 - 0.0016 18.4 0.0 0.0079 16.2 0.0 2.1 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.16 VDK82214.1 - 0.038 12.5 0.0 0.068 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain WD40 PF00400.32 VDK82216.1 - 9.3e-17 61.1 0.8 0.014 16.3 0.0 7.7 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK82216.1 - 1.1e-09 38.4 0.0 0.015 15.6 0.0 5.8 6 0 0 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Prefoldin PF02996.17 VDK82218.1 - 2.7e-23 82.2 0.2 3.4e-23 81.8 0.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit RNase_PH PF01138.21 VDK82219.1 - 2.3e-19 70.2 0.0 4.5e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 VDK82219.1 - 1.4e-11 44.2 0.0 2.9e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Alba PF01918.21 VDK82219.1 - 0.02 14.7 0.3 0.12 12.2 0.0 2.5 2 1 0 2 2 2 0 Alba Sec63 PF02889.16 VDK82233.1 - 1.5e-16 60.4 0.0 1.8e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain Transketolase_N PF00456.21 VDK82234.1 - 1.8e-38 132.4 0.2 3.1e-38 131.6 0.2 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 VDK82234.1 - 4.5e-35 120.9 0.0 7.4e-35 120.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 VDK82234.1 - 6.4e-29 100.4 0.2 1.5e-28 99.2 0.2 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_C PF02775.21 VDK82234.1 - 0.0022 17.8 0.4 0.012 15.4 0.4 2.1 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 VDK82234.1 - 0.014 14.4 0.1 0.022 13.7 0.1 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component PFOR_II PF17147.4 VDK82234.1 - 0.062 13.6 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II tRNA-synt_1c PF00749.21 VDK82236.1 - 1.7e-111 372.1 1.0 1.7e-111 372.1 1.0 2.4 3 0 0 3 3 2 1 tRNA synthetases class I (E and Q), catalytic domain WHEP-TRS PF00458.20 VDK82236.1 - 1.6e-52 175.5 23.6 9.5e-19 67.3 0.5 4.8 4 0 0 4 4 4 4 WHEP-TRS domain tRNA-synt_1c_C PF03950.18 VDK82236.1 - 1.5e-32 112.9 1.2 6.1e-32 110.9 1.2 2.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain ProRS-C_1 PF09180.11 VDK82236.1 - 1.7e-19 69.8 0.1 5.4e-19 68.2 0.1 2.0 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 VDK82236.1 - 4e-17 62.8 0.0 2.2e-16 60.3 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 VDK82236.1 - 2.1e-16 59.9 2.2 1.9e-15 56.7 0.3 2.9 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_1e PF01406.19 VDK82236.1 - 0.00013 21.4 0.2 0.00033 20.1 0.2 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF5460 PF17544.2 VDK82236.1 - 0.0011 18.1 1.7 0.35 9.8 0.3 3.2 2 1 1 3 3 3 2 Family of unknown function (DUF5460) GST_C_3 PF14497.6 VDK82236.1 - 0.013 15.7 0.1 0.086 13.0 0.1 2.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain TMEM192 PF14802.6 VDK82236.1 - 0.12 11.4 1.5 28 3.7 0.1 4.0 4 1 0 4 4 4 0 TMEM192 family GST_C PF00043.25 VDK82236.1 - 0.15 12.3 0.3 1.3 9.3 0.0 2.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Peptidase_S46 PF10459.9 VDK82236.1 - 0.66 8.5 17.5 0.074 11.7 11.7 2.1 1 1 1 2 2 2 0 Peptidase S46 WW PF00397.26 VDK82237.1 - 1.3e-06 28.3 1.4 3.4e-06 27.0 1.4 1.8 1 0 0 1 1 1 1 WW domain CRISPR_assoc PF08798.11 VDK82237.1 - 0.045 13.8 0.1 0.063 13.4 0.1 1.2 1 0 0 1 1 1 0 CRISPR associated protein RPGR1_C PF18111.1 VDK82239.1 - 6e-07 29.5 0.0 1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Retinitis pigmentosa G-protein regulator interacting C-terminal DUF4248 PF14053.6 VDK82239.1 - 0.17 11.9 0.1 45 4.2 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4248) C2-C2_1 PF11618.8 VDK82242.1 - 1.4e-33 115.9 0.1 1.8e-28 99.4 0.1 3.5 3 0 0 3 3 3 2 First C2 domain of RPGR-interacting protein 1 C2 PF00168.30 VDK82242.1 - 0.00073 19.8 0.0 0.0015 18.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain GH97_N PF14508.6 VDK82242.1 - 0.14 11.7 0.0 0.14 11.7 0.0 2.6 2 1 1 3 3 3 0 Glycosyl-hydrolase 97 N-terminal Acetyltransf_11 PF13720.6 VDK82242.1 - 3.3 8.3 14.4 3.6 8.1 0.1 4.6 3 1 2 5 5 5 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DASH_Spc34 PF08657.10 VDK82242.1 - 4 7.2 47.9 4.1 7.1 6.1 4.4 2 2 1 4 4 4 0 DASH complex subunit Spc34 DUF3800 PF12686.7 VDK82242.1 - 4.6 7.9 6.6 3.2e+02 1.9 6.4 3.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) PDZ PF00595.24 VDK82243.1 - 8.1e-11 42.1 0.1 1.3e-10 41.4 0.1 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK82243.1 - 1.2e-08 34.7 0.1 2e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK82243.1 - 2.7e-06 27.6 0.0 4.7e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDK82244.1 - 1e-38 131.5 3.1 1.7e-18 66.7 0.5 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK82244.1 - 2.2e-19 69.0 3.4 5.4e-09 35.8 0.6 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDK82244.1 - 3e-15 56.3 4.0 5.1e-07 29.9 0.4 2.7 2 1 0 2 2 2 2 PDZ domain Crinivirus_P26 PF07416.11 VDK82244.1 - 0.16 11.7 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Crinivirus P26 protein Thyroglobulin_1 PF00086.18 VDK82248.1 - 4e-12 45.6 3.0 4e-12 45.6 3.0 1.8 2 0 0 2 2 2 1 Thyroglobulin type-1 repeat SPARC_Ca_bdg PF10591.9 VDK82248.1 - 3e-11 43.6 0.9 3e-11 43.6 0.9 1.8 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 PF13499.6 VDK82248.1 - 0.00036 20.9 0.9 0.0035 17.7 0.5 2.6 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 VDK82248.1 - 0.0023 17.4 0.2 1.8 8.3 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 VDK82248.1 - 0.015 15.2 0.0 7.5 6.8 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain Chromo PF00385.24 VDK82249.1 - 0.00035 20.4 2.7 0.0018 18.1 0.6 2.6 2 1 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain NSP2-B_epitope PF14757.6 VDK82249.1 - 0.053 13.2 0.3 0.066 12.9 0.3 1.1 1 0 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein ANAPC_CDC26 PF10471.9 VDK82249.1 - 0.82 10.6 4.0 1.3 9.9 4.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 FAM104 PF15434.6 VDK82250.1 - 3.7 8.1 11.0 0.099 13.2 1.6 2.6 2 1 1 3 3 3 0 Family 104 MARVEL PF01284.23 VDK82251.1 - 0.00025 21.1 13.4 0.00035 20.6 13.4 1.2 1 0 0 1 1 1 1 Membrane-associating domain YwiC PF14256.6 VDK82251.1 - 0.15 12.4 3.9 0.24 11.7 3.9 1.5 1 0 0 1 1 1 0 YwiC-like protein RDD PF06271.12 VDK82251.1 - 1.2 9.4 7.3 3.5 7.8 0.0 2.6 1 1 2 3 3 3 0 RDD family DUF2842 PF11003.8 VDK82251.1 - 3.4 8.0 8.1 1.1 9.6 4.6 1.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2842) Kinesin PF00225.23 VDK82252.1 - 1.7e-17 63.4 0.0 1.7e-17 63.4 0.0 3.7 4 1 0 4 4 4 1 Kinesin motor domain Plus-3 PF03126.18 VDK82252.1 - 1.7e-15 57.5 1.4 8.6e-12 45.5 0.4 3.3 1 1 1 2 2 2 2 Plus-3 domain Viral_P18 PF04521.13 VDK82252.1 - 1 9.2 9.6 5 6.9 0.4 2.8 2 0 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein UIM PF02809.20 VDK82252.1 - 1.3 9.1 5.4 0.75 9.9 2.1 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif DUF2400 PF09674.10 VDK82257.1 - 0.12 12.4 1.7 0.19 11.7 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) PX PF00787.24 VDK82258.1 - 6.6e-26 90.5 0.0 8.3e-26 90.2 0.0 1.1 1 0 0 1 1 1 1 PX domain Vps51 PF08700.11 VDK82259.1 - 3.4e-21 75.1 4.4 3.4e-21 75.1 4.4 2.4 2 0 0 2 2 2 1 Vps51/Vps67 Sec5 PF15469.6 VDK82259.1 - 5.3e-13 49.2 3.2 5.3e-13 49.2 3.2 2.5 3 1 0 3 3 3 1 Exocyst complex component Sec5 Dor1 PF04124.12 VDK82259.1 - 4.1e-10 38.9 3.4 4.1e-10 38.9 3.4 2.1 3 0 0 3 3 3 1 Dor1-like family COG2 PF06148.11 VDK82259.1 - 0.00013 22.0 3.8 0.00013 22.0 3.8 2.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps54_N PF10475.9 VDK82259.1 - 0.00039 19.8 6.5 0.00039 19.8 6.5 3.1 2 1 1 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex Vps53_N PF04100.12 VDK82259.1 - 0.0007 18.7 10.5 0.00099 18.2 4.6 2.9 3 0 0 3 3 3 1 Vps53-like, N-terminal COG5 PF10392.9 VDK82259.1 - 0.0022 18.2 1.6 0.0022 18.2 1.6 2.9 3 0 0 3 3 3 1 Golgi transport complex subunit 5 Occludin_ELL PF07303.13 VDK82259.1 - 0.042 14.6 0.8 0.17 12.6 0.8 2.2 1 0 0 1 1 1 0 Occludin homology domain DUF4472 PF14739.6 VDK82259.1 - 0.061 14.1 1.3 0.16 12.7 0.5 2.2 2 0 0 2 2 1 0 Domain of unknown function (DUF4472) MbeB_N PF04837.12 VDK82259.1 - 0.39 11.1 3.3 0.64 10.4 0.7 2.7 2 1 0 2 2 2 0 MbeB-like, N-term conserved region SKA2 PF16740.5 VDK82259.1 - 0.83 9.5 9.0 0.18 11.6 1.4 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF1664 PF07889.12 VDK82259.1 - 1.5 8.8 6.1 12 6.0 0.7 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 VDK82259.1 - 5.5 7.0 10.0 1.1 9.3 3.1 3.2 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Peptidase_M14 PF00246.24 VDK82260.1 - 3.5e-74 250.2 0.1 1.4e-73 248.2 0.0 1.9 1 1 1 2 2 2 1 Zinc carboxypeptidase Propep_M14 PF02244.16 VDK82260.1 - 5.6e-10 39.5 1.1 1.2e-09 38.5 1.1 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide ShK PF01549.24 VDK82260.1 - 1.2e-06 28.9 4.9 2.4e-06 28.0 4.9 1.6 1 0 0 1 1 1 1 ShK domain-like Peptidase_M14 PF00246.24 VDK82261.1 - 1.4e-90 304.0 0.0 2e-90 303.5 0.0 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase ShK PF01549.24 VDK82261.1 - 1.7e-05 25.3 7.6 3.7e-05 24.2 7.6 1.6 1 0 0 1 1 1 1 ShK domain-like SR-25 PF10500.9 VDK82261.1 - 0.081 12.5 7.4 0.13 11.9 7.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GYF_2 PF14237.6 VDK82276.1 - 2.1e-14 53.0 0.6 4.2e-14 52.1 0.6 1.6 1 0 0 1 1 1 1 GYF domain 2 DnaJ PF00226.31 VDK82276.1 - 4.9e-11 42.6 0.1 1.1e-10 41.4 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain Innexin PF00876.18 VDK82278.1 - 1.5e-121 406.0 13.5 1.8e-121 405.7 13.5 1.0 1 0 0 1 1 1 1 Innexin Innexin PF00876.18 VDK82279.1 - 4.2e-103 345.3 10.5 5e-103 345.1 10.5 1.0 1 0 0 1 1 1 1 Innexin GNT-I PF03071.15 VDK82280.1 - 3.4e-116 388.6 0.1 4.5e-116 388.2 0.1 1.0 1 0 0 1 1 1 1 GNT-I family Beta-Casp PF10996.8 VDK82280.1 - 0.18 12.1 0.0 0.34 11.2 0.0 1.4 1 0 0 1 1 1 0 Beta-Casp domain PrmA PF06325.13 VDK82286.1 - 3.5e-10 39.8 0.1 5.8e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 VDK82286.1 - 3.5e-08 34.0 0.0 1.3e-07 32.2 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK82286.1 - 1.6e-06 28.0 0.0 2.7e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK82286.1 - 1.7e-06 28.6 0.0 4.5e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK82286.1 - 3.1e-05 23.6 1.0 5.2e-05 22.9 0.2 1.7 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_23 PF13489.6 VDK82286.1 - 0.00021 21.2 0.0 0.00042 20.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 VDK82286.1 - 0.00025 21.0 0.2 0.00049 20.1 0.2 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 VDK82286.1 - 0.00029 20.7 0.3 0.00049 19.9 0.3 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_12 PF08242.12 VDK82286.1 - 0.0012 19.5 0.0 0.0034 18.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 VDK82286.1 - 0.002 17.5 0.1 0.003 16.9 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PRMT5 PF05185.16 VDK82286.1 - 0.0024 17.7 0.1 0.0043 16.9 0.1 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_16 PF10294.9 VDK82286.1 - 0.0026 17.5 0.9 0.014 15.2 0.1 2.1 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_9 PF08003.11 VDK82286.1 - 0.0042 16.1 0.0 0.0062 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) DOT1 PF08123.13 VDK82286.1 - 0.0045 16.5 0.1 0.01 15.4 0.1 1.5 1 0 0 1 1 1 1 Histone methylation protein DOT1 PCMT PF01135.19 VDK82286.1 - 0.006 16.4 0.0 0.0093 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 VDK82286.1 - 0.0091 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 VDK82286.1 - 0.069 13.1 0.1 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_24 PF13578.6 VDK82286.1 - 0.093 13.8 0.0 0.21 12.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 VDK82286.1 - 0.095 11.7 0.1 0.18 10.8 0.1 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Acetyltransf_1 PF00583.25 VDK82288.1 - 1.3e-16 60.9 0.0 1.9e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 VDK82288.1 - 1.5e-10 41.4 0.0 2.5e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 VDK82288.1 - 2.7e-10 40.3 0.0 5.1e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 VDK82288.1 - 4.9e-09 36.0 0.0 1.1e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 VDK82288.1 - 0.00067 19.3 0.0 0.001 18.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 VDK82288.1 - 0.0025 17.9 0.3 0.027 14.6 0.0 2.1 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 VDK82288.1 - 0.0034 18.1 0.0 0.0044 17.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 VDK82288.1 - 0.014 15.5 0.0 0.026 14.7 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Pan3_PK PF18101.1 VDK82288.1 - 0.028 14.4 0.1 0.07 13.1 0.1 1.6 1 0 0 1 1 1 0 Pan3 Pseudokinase domain PanZ PF12568.8 VDK82288.1 - 0.073 12.8 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ HTH_41 PF14502.6 VDK82288.1 - 0.092 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Acetyltransf_CG PF14542.6 VDK82288.1 - 0.1 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase SPT16 PF08644.11 VDK82289.1 - 4.7e-55 185.9 0.1 4.7e-55 185.9 0.1 2.8 3 0 0 3 3 3 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 VDK82289.1 - 2.5e-44 150.9 0.5 2.5e-44 150.9 0.5 2.2 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 VDK82289.1 - 4.1e-25 88.7 0.0 6.5e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 VDK82289.1 - 1.1e-16 61.0 0.2 3.2e-16 59.5 0.2 1.9 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Sulfatase PF00884.23 VDK82290.1 - 8.3e-69 232.3 0.0 1.2e-68 231.8 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 VDK82290.1 - 4.8e-30 104.9 0.5 1.1e-29 103.7 0.5 1.5 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 VDK82290.1 - 0.00012 21.8 0.0 0.0011 18.7 0.0 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 VDK82290.1 - 0.0054 15.4 0.0 0.0069 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Ribul_P_3_epim PF00834.19 VDK82291.1 - 5.5e-63 211.9 0.2 6.5e-63 211.7 0.2 1.0 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 VDK82291.1 - 0.0012 18.7 0.0 0.0037 17.0 0.0 1.7 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 VDK82291.1 - 0.0036 16.8 0.2 0.42 10.0 0.1 2.4 1 1 1 2 2 2 2 Histidine biosynthesis protein GATase PF00117.28 VDK82291.1 - 0.14 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferase class-I YkyA PF10368.9 VDK82292.1 - 0.23 11.1 9.9 2.8 7.6 5.3 2.6 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein EST1 PF10374.9 VDK82292.1 - 1 10.0 4.2 2.5 8.7 1.5 2.5 2 2 0 2 2 2 0 Telomerase activating protein Est1 HAUS6_N PF14661.6 VDK82292.1 - 1.7 8.2 8.5 23 4.5 8.4 2.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus HR1 PF02185.16 VDK82292.1 - 7.2 6.8 8.8 5.2 7.3 4.9 2.6 2 1 0 2 2 2 0 Hr1 repeat zf-C4H2 PF10146.9 VDK82292.1 - 8.2 6.7 11.1 1.2e+02 2.9 11.0 2.4 1 1 0 1 1 1 0 Zinc finger-containing protein APG6_N PF17675.1 VDK82292.1 - 8.6 6.9 9.4 1.1 9.9 2.8 2.5 3 0 0 3 3 3 0 Apg6 coiled-coil region Homeobox_KN PF05920.11 VDK82296.1 - 1.4e-18 66.4 0.1 4e-18 65.0 0.1 1.8 1 0 0 1 1 1 1 Homeobox KN domain Meis_PKNOX_N PF16493.5 VDK82296.1 - 3.4e-14 52.9 0.3 1.3e-13 51.1 0.1 2.0 2 0 0 2 2 2 1 N-terminal of Homeobox Meis and PKNOX1 Homeodomain PF00046.29 VDK82296.1 - 4.5e-07 29.6 0.2 1e-06 28.5 0.2 1.6 1 0 0 1 1 1 1 Homeodomain zf-C4 PF00105.18 VDK82298.1 - 4.1e-15 56.0 7.4 4.1e-15 56.0 7.4 1.7 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK82298.1 - 6.4e-07 29.1 0.6 2.2e-06 27.4 0.3 2.0 2 0 0 2 2 2 1 Ligand-binding domain of nuclear hormone receptor DNA_repr_REX1B PF14966.6 VDK82300.1 - 0.069 13.8 0.0 0.13 13.0 0.0 1.5 1 1 0 1 1 1 0 DNA repair REX1-B DUF4914 PF16260.5 VDK82300.1 - 0.12 10.5 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) MATH PF00917.26 VDK82302.1 - 2e-13 50.5 0.1 2e-13 50.5 0.1 2.5 3 0 0 3 3 3 1 MATH domain DUF812 PF05667.11 VDK82302.1 - 0.00023 20.2 33.8 0.00023 20.2 33.8 4.0 3 1 1 4 4 4 1 Protein of unknown function (DUF812) DUF4211 PF13926.6 VDK82303.1 - 9.1e-09 35.5 0.2 2.9e-08 33.9 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4211) Dus PF01207.17 VDK82313.1 - 2.2e-64 217.5 0.0 2.8e-64 217.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) NanE PF04131.14 VDK82313.1 - 3.6e-05 23.0 0.0 5.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase TMP-TENI PF02581.17 VDK82313.1 - 0.044 13.1 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase SOR_SNZ PF01680.17 VDK82313.1 - 0.045 13.5 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 SOR/SNZ family DUF561 PF04481.12 VDK82313.1 - 0.067 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF561) BKACE PF05853.12 VDK82313.1 - 0.17 11.1 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme SNF2_N PF00176.23 VDK82315.1 - 2.2e-72 243.7 0.6 4.1e-72 242.8 0.6 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 VDK82315.1 - 2.2e-42 143.7 3.7 2.2e-42 143.7 3.7 4.3 5 0 0 5 5 5 1 SLIDE HAND PF09110.11 VDK82315.1 - 2.1e-30 105.7 4.6 2.1e-30 105.7 4.6 4.1 4 0 0 4 4 4 1 HAND Helicase_C PF00271.31 VDK82315.1 - 2.4e-21 76.2 0.1 2.4e-20 73.0 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK82315.1 - 4.6e-11 43.0 0.0 4.6e-11 43.0 0.0 2.7 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 VDK82315.1 - 1.8e-06 27.9 0.1 7.4e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 VDK82315.1 - 1.1e-05 24.8 0.5 3.2e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DUF1086 PF06461.11 VDK82315.1 - 0.00039 20.3 0.7 0.0019 18.1 0.4 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1086) Myb_DNA-binding PF00249.31 VDK82315.1 - 0.0012 19.0 6.0 0.034 14.3 0.1 3.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain Linker_histone PF00538.19 VDK82316.1 - 5.5e-27 93.9 0.3 5.5e-27 93.9 0.3 1.9 2 0 0 2 2 2 1 linker histone H1 and H5 family Histone PF00125.24 VDK82317.1 - 9.2e-54 181.3 1.9 1e-53 181.1 1.9 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 VDK82317.1 - 5.5e-05 23.2 0.1 0.00043 20.4 0.0 2.0 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 VDK82317.1 - 0.00061 20.4 2.3 0.00079 20.0 2.3 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-S PF15630.6 VDK82317.1 - 0.00082 19.7 0.0 0.0016 18.7 0.0 1.5 2 0 0 2 2 2 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 VDK82317.1 - 0.029 14.6 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 VDK82317.1 - 0.087 12.9 0.2 0.17 12.0 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Histone_H2A_C PF16211.5 VDK82318.1 - 3.2e-20 71.5 1.0 6.1e-20 70.7 1.0 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 VDK82318.1 - 2e-16 60.6 0.0 2.4e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 VDK82318.1 - 1.4e-05 25.3 0.0 1.9e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK82319.1 - 3.8e-11 43.5 0.2 4.9e-11 43.1 0.2 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 VDK82319.1 - 0.012 15.8 0.3 0.02 15.2 0.1 1.5 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 VDK82319.1 - 0.015 15.8 0.1 0.027 15.0 0.1 1.5 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A DUF1931 PF09123.11 VDK82319.1 - 0.12 12.4 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) Tospo_nucleocap PF01533.16 VDK82321.1 - 0.088 12.3 0.1 0.088 12.3 0.1 1.0 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein CENP-T_C PF15511.6 VDK82323.1 - 3.6e-08 33.5 0.1 4.4e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 VDK82323.1 - 1.8e-05 25.0 0.1 2.4e-05 24.6 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein TAF PF02969.17 VDK82323.1 - 6.9e-05 22.9 0.1 9.7e-05 22.5 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 VDK82323.1 - 7e-05 23.0 0.1 0.00012 22.3 0.1 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK82323.1 - 0.00023 21.5 0.2 0.00026 21.3 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 VDK82323.1 - 0.0036 17.3 0.0 0.0055 16.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 VDK82323.1 - 0.009 16.1 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CWC25 PF12542.8 VDK82326.1 - 1.2e-10 42.2 0.1 1.2e-10 42.2 0.1 3.6 2 1 1 3 3 3 1 Pre-mRNA splicing factor NTP_transferase PF00483.23 VDK82327.1 - 2.1e-45 155.2 0.0 2.8e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 VDK82327.1 - 5.8e-14 51.2 36.9 3.4e-07 29.7 2.3 3.6 1 1 4 5 5 5 5 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 VDK82327.1 - 2.9e-08 34.2 0.0 4.6e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 VDK82327.1 - 9.6e-05 22.1 11.3 0.00085 19.0 1.2 3.6 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 VDK82327.1 - 0.0048 15.1 0.5 0.0074 14.5 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) IspD PF01128.19 VDK82327.1 - 0.0059 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase INCENP_ARK-bind PF03941.15 VDK82328.1 - 1e-17 63.8 0.2 2.4e-17 62.6 0.2 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region HlyD_D23 PF16576.5 VDK82328.1 - 0.019 14.2 5.2 0.014 14.6 2.6 2.0 2 0 0 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion DUF5114 PF17141.4 VDK82328.1 - 0.028 14.9 1.3 0.19 12.3 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5114) Alg6_Alg8 PF03155.15 VDK82330.1 - 7.2e-76 256.1 32.5 2.5e-68 231.2 24.8 3.0 1 1 2 3 3 3 3 ALG6, ALG8 glycosyltransferase family Aminotran_1_2 PF00155.21 VDK82340.1 - 3.4e-34 118.6 0.0 3.7e-34 118.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 VDK82340.1 - 0.052 12.8 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family SLD5_C PF16922.5 VDK82342.1 - 2.1e-06 27.8 0.0 2.2e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 VDK82342.1 - 0.00054 20.4 0.4 0.00097 19.6 0.4 1.5 1 0 0 1 1 1 1 GINS complex protein DNA_pol3_a_NII PF11490.8 VDK82342.1 - 0.04 13.8 0.2 0.1 12.5 0.2 1.7 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II SWIRM-assoc_1 PF16495.5 VDK82343.1 - 1.8e-30 104.7 14.8 3.9e-30 103.6 14.8 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 SWIRM PF04433.17 VDK82343.1 - 2.3e-29 101.5 0.6 4.3e-29 100.7 0.0 1.8 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_3 PF16498.5 VDK82343.1 - 2.2e-23 82.3 3.7 2.2e-23 82.3 3.7 2.6 2 0 0 2 2 2 1 SWIRM-associated domain at the C-terminal Myb_DNA-binding PF00249.31 VDK82343.1 - 4.1e-10 39.7 0.0 7.5e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 VDK82343.1 - 2.2e-07 31.0 0.0 4.6e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain HalX PF08663.10 VDK82344.1 - 0.00095 19.4 3.9 0.0012 19.1 1.7 2.1 1 1 1 2 2 2 2 HalX domain Flagellar_rod PF05149.12 VDK82344.1 - 0.0016 18.0 7.3 0.011 15.2 6.9 1.9 1 1 0 1 1 1 1 Paraflagellar rod protein Dynactin_p22 PF07426.11 VDK82344.1 - 0.0023 17.8 3.8 0.0026 17.6 3.1 1.5 1 1 0 1 1 1 1 Dynactin subunit p22 NYD-SP28 PF14772.6 VDK82344.1 - 0.0025 17.8 5.1 0.1 12.6 0.8 2.6 1 1 1 2 2 2 1 Sperm tail DASH_Spc34 PF08657.10 VDK82344.1 - 0.0045 16.8 6.6 0.017 15.0 6.6 1.8 1 1 0 1 1 1 1 DASH complex subunit Spc34 Fib_alpha PF08702.10 VDK82344.1 - 0.0055 16.9 8.5 0.04 14.1 4.2 2.0 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family FliJ PF02050.16 VDK82344.1 - 0.017 15.3 3.2 0.017 15.3 3.2 2.1 1 1 1 2 2 2 0 Flagellar FliJ protein Spc7 PF08317.11 VDK82344.1 - 0.042 12.7 8.7 0.06 12.2 8.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YvfG PF09628.10 VDK82344.1 - 0.049 14.0 1.9 0.32 11.4 0.2 2.2 2 0 0 2 2 2 0 YvfG protein WXG100 PF06013.12 VDK82344.1 - 0.08 13.2 1.9 6.1 7.2 0.1 2.6 2 1 0 2 2 2 0 Proteins of 100 residues with WXG T4SS PF07996.11 VDK82344.1 - 0.082 13.3 2.6 0.81 10.1 0.1 2.1 1 1 0 2 2 2 0 Type IV secretion system proteins DUF1192 PF06698.11 VDK82344.1 - 0.089 12.9 3.7 0.33 11.0 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF948 PF06103.11 VDK82344.1 - 0.1 12.9 1.0 1.2 9.5 1.0 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 VDK82344.1 - 0.1 13.1 2.4 0.76 10.3 0.7 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin_2 PF14523.6 VDK82344.1 - 0.11 12.9 3.8 0.42 11.0 2.2 2.5 1 1 2 3 3 3 0 Syntaxin-like protein FapA PF03961.13 VDK82344.1 - 0.14 10.7 7.7 0.2 10.2 7.7 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A Cep57_MT_bd PF06657.13 VDK82344.1 - 0.19 12.2 9.4 1.8 9.0 1.0 2.7 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Seryl_tRNA_N PF02403.22 VDK82344.1 - 0.21 11.8 8.7 0.3 11.3 2.8 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DASH_Dad3 PF08656.10 VDK82344.1 - 0.21 11.7 5.8 4 7.6 0.3 2.8 2 1 0 2 2 2 0 DASH complex subunit Dad3 Nup54 PF13874.6 VDK82344.1 - 0.21 11.7 5.6 5.1 7.2 0.3 2.0 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF2508 PF10704.9 VDK82344.1 - 0.23 11.6 0.3 0.23 11.6 0.3 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2508) MutS_III PF05192.18 VDK82344.1 - 0.26 11.5 1.9 0.31 11.2 1.9 1.1 1 0 0 1 1 1 0 MutS domain III Phage_Mu_Gam PF07352.12 VDK82344.1 - 0.3 11.0 8.2 1 9.2 2.6 2.2 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein ZnuA PF01297.17 VDK82344.1 - 0.38 10.1 2.9 0.58 9.5 2.9 1.5 1 1 0 1 1 1 0 Zinc-uptake complex component A periplasmic DUF4140 PF13600.6 VDK82344.1 - 0.41 11.1 2.9 1 9.8 0.3 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF16 PF01519.16 VDK82344.1 - 0.41 11.2 5.2 4.4 7.8 5.2 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 RasGAP_C PF03836.15 VDK82344.1 - 0.49 10.5 8.0 0.3 11.2 5.2 1.9 1 1 1 2 2 2 0 RasGAP C-terminus DUF1664 PF07889.12 VDK82344.1 - 0.51 10.4 5.9 0.43 10.6 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 VDK82344.1 - 0.81 9.0 4.8 1.5 8.1 4.8 1.5 1 1 0 1 1 1 0 FAM76 protein BLOC1_2 PF10046.9 VDK82344.1 - 1 9.7 9.3 4.5 7.6 5.2 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UPF0242 PF06785.11 VDK82344.1 - 1.9 8.6 11.4 4 7.5 11.4 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMPIT PF07851.13 VDK82344.1 - 1.9 7.7 5.9 6.2 6.0 1.3 2.0 1 1 1 2 2 2 0 TMPIT-like protein LsmAD PF06741.13 VDK82344.1 - 2.7 8.6 7.0 5.3 7.7 0.5 2.7 1 1 2 3 3 3 0 LsmAD domain GCP_C_terminal PF04130.13 VDK82347.1 - 5.8e-16 58.8 4.1 5.8e-16 58.8 4.1 2.3 2 1 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 VDK82347.1 - 0.0082 15.8 0.9 0.062 12.9 0.0 2.5 2 1 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF5099 PF17025.5 VDK82347.1 - 0.066 13.6 0.1 0.26 11.7 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5099) ASC PF00858.24 VDK82350.1 - 3.2e-16 59.4 24.5 7.3e-16 58.2 20.5 2.5 2 1 0 2 2 2 1 Amiloride-sensitive sodium channel Vps54_N PF10475.9 VDK82351.1 - 3.4e-12 46.3 1.2 5.3e-12 45.6 1.2 1.2 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Sec8_exocyst PF04048.14 VDK82351.1 - 0.024 14.5 0.2 0.052 13.4 0.2 1.5 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain TPR_1 PF00515.28 VDK82351.1 - 0.083 12.7 0.0 0.3 11.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF354 PF04007.12 VDK82354.1 - 0.16 11.0 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF354) Oxidored_q5_N PF01059.17 VDK82354.1 - 3.2 7.9 9.6 0.1 12.7 1.7 2.3 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus MIP PF00230.20 VDK82354.1 - 6.6 6.4 9.0 11 5.6 2.8 2.5 2 1 0 2 2 2 0 Major intrinsic protein Glyco_transf_11 PF01531.16 VDK82356.1 - 2.5e-26 92.6 10.9 5.2e-25 88.3 10.9 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 11 NodZ PF05830.11 VDK82356.1 - 0.074 11.8 0.1 0.13 11.0 0.1 1.5 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) MRP-S31 PF15433.6 VDK82357.1 - 0.44 10.2 12.0 0.52 9.9 12.0 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 PIEZO PF15917.5 VDK82357.1 - 0.65 9.4 10.5 0.9 9.0 10.5 1.2 1 0 0 1 1 1 0 Piezo BTB PF00651.31 VDK82359.1 - 0.0002 21.6 0.0 0.00039 20.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2 PF00096.26 VDK82359.1 - 0.013 15.9 27.1 0.014 15.8 1.9 4.4 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 VDK82359.1 - 0.021 15.2 7.6 0.081 13.3 1.0 2.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 VDK82359.1 - 0.023 15.0 3.7 2.3 8.6 0.2 3.5 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 VDK82359.1 - 0.047 14.5 25.4 0.4 11.7 1.3 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK82359.1 - 1.6 8.6 14.9 0.65 9.8 0.4 3.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain RNA_POL_M_15KD PF02150.16 VDK82359.1 - 1.6 8.6 7.0 2.5 8.1 0.1 2.9 2 1 1 3 3 3 0 RNA polymerases M/15 Kd subunit zf_C2H2_ZHX PF18387.1 VDK82359.1 - 1.8 8.3 8.7 0.91 9.2 0.5 2.8 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_9 PF16293.5 VDK82359.1 - 2.5 8.0 5.2 30 4.6 0.2 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Ion_trans PF00520.31 VDK82360.1 - 3.6e-68 229.4 33.5 8.5e-39 133.2 16.7 2.2 2 0 0 2 2 2 2 Ion transport protein BTB_2 PF02214.22 VDK82360.1 - 4.7e-27 94.2 0.0 1.1e-26 92.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 VDK82360.1 - 2.1e-19 69.2 27.0 1.1e-10 41.4 5.4 3.2 3 0 0 3 3 3 2 Ion channel DUF1616 PF07760.11 VDK82360.1 - 0.078 12.4 1.2 3.4 7.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) PKD_channel PF08016.12 VDK82360.1 - 0.41 9.3 24.4 0.14 10.8 8.1 2.2 2 0 0 2 2 2 0 Polycystin cation channel AtpR PF12966.7 VDK82360.1 - 2.8 8.5 12.1 0.68 10.4 1.3 3.3 3 0 0 3 3 3 0 N-ATPase, AtpR subunit FixQ PF05545.11 VDK82360.1 - 6.4 6.8 8.0 6.8 6.7 0.2 3.3 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ AAA PF00004.29 VDK82362.1 - 2.7e-27 95.8 0.0 1.5e-25 90.1 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK82362.1 - 2.3e-07 30.5 1.0 5.8e-07 29.2 0.8 1.9 1 1 0 1 1 1 1 AAA+ lid domain PDZ PF00595.24 VDK82364.1 - 5.4e-06 26.7 0.0 1.8e-05 25.0 0.0 1.9 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK82364.1 - 0.022 14.6 0.0 0.07 13.0 0.0 1.9 1 0 0 1 1 1 0 PDZ domain PDZ_2 PF13180.6 VDK82364.1 - 0.079 13.3 0.0 0.21 11.9 0.0 1.7 1 0 0 1 1 1 0 PDZ domain ProQ_C PF17516.2 VDK82365.1 - 0.0047 16.3 3.2 0.28 10.7 0.7 2.7 2 0 0 2 2 2 2 ProQ C-terminal domain Peptidase_M10 PF00413.24 VDK82366.1 - 5.6e-47 159.5 0.2 9.2e-47 158.8 0.2 1.3 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 VDK82366.1 - 9.4e-10 38.6 0.0 2.8e-09 37.0 0.0 1.9 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Reprolysin_5 PF13688.6 VDK82366.1 - 8.5e-06 26.0 0.0 1.3e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 VDK82366.1 - 3e-05 23.7 0.0 6.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 VDK82366.1 - 9.9e-05 22.0 1.2 0.0026 17.4 0.2 2.4 2 0 0 2 2 2 1 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 VDK82366.1 - 0.00034 21.1 0.0 0.00062 20.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 VDK82366.1 - 0.001 19.0 0.0 0.0021 18.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Hemopexin PF00045.19 VDK82366.1 - 0.0022 17.9 0.3 0.18 11.8 0.0 3.0 3 0 0 3 3 3 1 Hemopexin Peptidase_M7 PF02031.16 VDK82366.1 - 0.0095 16.1 0.2 0.076 13.1 0.1 2.4 2 1 0 2 2 2 1 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M54 PF07998.11 VDK82366.1 - 0.011 15.7 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M54 DUF4953 PF16313.5 VDK82366.1 - 0.02 14.1 3.7 0.25 10.5 3.7 2.1 1 1 0 1 1 1 0 Met-zincin Metallopep PF12044.8 VDK82366.1 - 0.024 13.3 0.0 0.039 12.6 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M43 PF05572.13 VDK82366.1 - 0.057 13.3 0.0 0.16 11.9 0.0 1.6 1 1 0 1 1 1 0 Pregnancy-associated plasma protein-A Peptidase_M57 PF12388.8 VDK82366.1 - 0.11 12.1 0.5 0.28 10.7 0.4 1.6 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase HD_4 PF13328.6 VDK82368.1 - 2.4e-26 92.3 0.3 3e-26 92.0 0.3 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.22 VDK82368.1 - 1.4e-06 28.6 0.3 4.3e-06 26.9 0.2 1.9 2 1 0 2 2 2 1 HD domain FGAR-AT_N PF18076.1 VDK82368.1 - 0.096 12.7 0.2 16 5.5 0.0 2.8 2 1 1 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase N-terminal RIO1 PF01163.22 VDK82375.1 - 3.9e-52 176.6 0.6 3.9e-52 176.6 0.6 1.7 2 0 0 2 2 2 1 RIO1 family Pkinase_fungal PF17667.1 VDK82375.1 - 0.028 13.2 0.1 0.036 12.8 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 VDK82375.1 - 0.06 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family NAD_binding_1 PF00175.21 VDK82376.1 - 3.9e-07 30.7 0.1 6.6e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF1451 PF07295.11 VDK82376.1 - 0.022 14.8 0.0 0.024 14.7 0.0 1.3 1 1 0 1 1 1 0 Zinc-ribbon containing domain bacHORMA_1 PF18138.1 VDK82376.1 - 0.027 14.4 0.1 1.9 8.4 0.0 2.0 2 0 0 2 2 2 0 Bacterial HORMA domain family 1 PGM_PMM_I PF02878.16 VDK82376.1 - 0.063 13.0 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I DUF3225 PF11533.8 VDK82376.1 - 0.34 10.6 2.7 0.86 9.3 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3225) FAD_binding_1 PF00667.20 VDK82377.1 - 1.4e-64 217.7 0.0 1.9e-64 217.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 VDK82377.1 - 3e-32 111.8 0.1 4.7e-32 111.2 0.1 1.3 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 VDK82377.1 - 0.00057 20.5 0.0 0.0028 18.3 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain SH2 PF00017.24 VDK82380.1 - 3.4e-13 49.5 0.0 1.3e-12 47.6 0.0 2.1 2 0 0 2 2 2 1 SH2 domain PH PF00169.29 VDK82380.1 - 9.7e-08 32.5 0.0 2.4e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 PH domain Phe_ZIP PF08916.11 VDK82380.1 - 0.00036 21.2 1.8 0.00042 21.0 0.3 1.9 2 0 0 2 2 2 1 Phenylalanine zipper SH2_2 PF14633.6 VDK82380.1 - 0.0049 16.3 0.0 0.0085 15.5 0.0 1.3 1 0 0 1 1 1 1 SH2 domain Frag1 PF10277.9 VDK82386.1 - 7.6e-28 97.5 26.9 1.8e-27 96.3 26.9 1.6 1 1 0 1 1 1 1 Frag1/DRAM/Sfk1 family zf-Di19 PF05605.12 VDK82388.1 - 0.0011 19.2 0.5 0.0028 17.9 0.5 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding DUF3795 PF12675.7 VDK82388.1 - 0.037 14.4 0.8 0.12 12.8 0.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3795) zf-C2H2_4 PF13894.6 VDK82388.1 - 0.049 14.5 7.7 0.35 11.8 1.7 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-RRPl_C4 PF17026.5 VDK82388.1 - 0.12 12.5 1.0 0.31 11.2 1.0 1.7 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type RNA_pol_I_TF PF04090.12 VDK82388.1 - 0.17 11.3 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific initiation factor zf-met PF12874.7 VDK82388.1 - 0.18 12.2 0.9 0.43 11.0 0.9 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK82388.1 - 0.21 11.9 1.4 0.64 10.4 1.4 1.9 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 VDK82388.1 - 0.44 10.3 3.9 0.17 11.7 0.8 1.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 VDK82388.1 - 0.74 10.5 4.3 1.2 9.8 2.3 2.5 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 VDK82388.1 - 0.82 10.0 5.9 0.64 10.4 0.4 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_4 PF13717.6 VDK82388.1 - 1.3 9.0 3.8 13 5.8 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2HE PF16278.5 VDK82388.1 - 1.5 9.3 5.5 11 6.6 1.8 3.1 2 1 1 3 3 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 VDK82388.1 - 3.5 8.3 8.7 7 7.3 2.4 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ribosomal_L11_N PF03946.14 VDK82390.1 - 3.6e-22 78.0 0.2 8e-22 76.9 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 VDK82390.1 - 5.9e-19 68.3 0.2 9.5e-19 67.7 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain DEAD PF00270.29 VDK82390.1 - 0.1 12.4 0.1 0.16 11.7 0.1 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase Ribosomal_L3 PF00297.22 VDK82391.1 - 2.1e-18 66.5 1.9 1.9e-17 63.3 1.6 1.9 1 1 1 2 2 2 1 Ribosomal protein L3 SPRY PF00622.28 VDK82391.1 - 4.2e-15 55.9 0.0 8.3e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 SPRY domain F-box-like PF12937.7 VDK82391.1 - 0.012 15.5 0.7 0.03 14.2 0.7 1.7 1 0 0 1 1 1 0 F-box-like Bystin PF05291.11 VDK82392.1 - 1.5e-133 444.5 4.4 2.1e-133 444.1 4.4 1.2 1 0 0 1 1 1 1 Bystin Orbi_NS3 PF01616.16 VDK82392.1 - 0.084 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Orbivirus NS3 Lectin_C PF00059.21 VDK82393.1 - 3.8e-06 27.6 0.0 0.012 16.3 0.0 2.8 2 1 0 2 2 2 2 Lectin C-type domain FERM_f0 PF16511.5 VDK82394.1 - 0.054 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM FerA PF08165.11 VDK82394.1 - 0.073 13.0 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 FerA (NUC095) domain zf-RING_10 PF16685.5 VDK82394.1 - 0.39 10.9 14.4 2.8 8.1 3.8 2.5 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-C3HC4 PF00097.25 VDK82394.1 - 1 9.3 20.8 0.26 11.2 8.5 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 VDK82394.1 - 2.2 8.1 18.8 0.67 9.8 3.5 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_2 PF13639.6 VDK82394.1 - 5.8 7.3 20.7 2.3 8.6 5.1 3.0 2 1 0 3 3 3 0 Ring finger domain DUF21 PF01595.20 VDK82395.1 - 4.3e-35 121.0 0.4 7e-35 120.3 0.4 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 VDK82395.1 - 0.0022 18.4 4.3 0.082 13.4 0.3 3.2 3 0 0 3 3 3 2 CBS domain Peptidase_M14 PF00246.24 VDK82401.1 - 7.4e-87 291.8 0.0 1.3e-86 291.1 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 VDK82401.1 - 3.6e-14 52.9 0.1 7.7e-14 51.9 0.1 1.5 1 0 0 1 1 1 1 Carboxypeptidase activation peptide LBP_BPI_CETP_C PF02886.17 VDK82402.1 - 5.8e-06 25.9 0.0 8.3e-05 22.1 0.0 2.5 3 0 0 3 3 3 1 LBP / BPI / CETP family, C-terminal domain TFIIS_M PF07500.14 VDK82403.1 - 1.9e-31 108.8 1.2 1.9e-31 108.8 1.2 1.6 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 VDK82403.1 - 1.9e-18 66.0 7.9 3.4e-18 65.2 7.9 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 VDK82403.1 - 4e-13 49.1 2.5 7.7e-13 48.3 2.5 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ku_C PF03730.14 VDK82403.1 - 0.11 13.2 1.5 0.17 12.6 0.2 2.0 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm GFA PF04828.14 VDK82403.1 - 0.72 10.2 7.6 3 8.2 0.8 3.0 2 1 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme Esterase PF00756.20 VDK82404.1 - 6.9e-50 170.0 0.0 8.1e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 VDK82404.1 - 0.002 17.1 0.0 0.003 16.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 VDK82404.1 - 0.0032 16.8 0.0 0.0046 16.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 VDK82404.1 - 0.006 16.1 0.0 0.0086 15.6 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family zf-C4 PF00105.18 VDK82405.1 - 1.2e-29 102.5 14.7 2.8e-29 101.4 14.7 1.6 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK82405.1 - 6.4e-09 35.7 1.3 6.4e-09 35.7 1.3 1.7 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor DnaGprimase_HBD PF16730.5 VDK82405.1 - 0.064 13.3 2.3 0.15 12.1 2.3 1.6 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain DUF3333 PF11812.8 VDK82405.1 - 0.079 13.2 0.0 2.7 8.2 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3333) Branch PF02485.21 VDK82410.1 - 4.2e-27 95.2 0.3 6.5e-27 94.6 0.3 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme WSC PF01822.19 VDK82410.1 - 6.9e-15 55.0 3.0 1.7e-14 53.7 3.0 1.7 1 0 0 1 1 1 1 WSC domain Xylo_C PF12529.8 VDK82410.1 - 3.3e-10 39.9 0.1 5.3e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 Xylosyltransferase C terminal PCO_ADO PF07847.12 VDK82411.1 - 3.3e-25 88.7 0.0 4.4e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 PCO_ADO DUF4711 PF15829.5 VDK82412.1 - 0.002 18.1 0.0 0.0022 18.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4711) DUF4577 PF15145.6 VDK82412.1 - 0.025 14.6 0.1 0.031 14.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) UL45 PF05473.12 VDK82412.1 - 0.067 12.8 0.0 0.081 12.6 0.0 1.1 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like DUF3675 PF12428.8 VDK82412.1 - 0.07 13.7 1.5 0.12 12.9 1.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3675) DUF5383 PF17355.2 VDK82412.1 - 0.12 12.8 0.1 0.18 12.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5383) DUF5305 PF17231.2 VDK82412.1 - 0.14 11.5 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Orf78 PF06024.12 VDK82412.1 - 0.18 12.1 0.0 0.23 11.8 0.0 1.1 1 0 0 1 1 1 0 Orf78 (ac78) Ribosomal_S30 PF04758.14 VDK82414.1 - 3.5e-28 97.6 7.9 3.5e-28 97.6 7.9 2.4 3 0 0 3 3 3 1 Ribosomal protein S30 AROS PF15684.5 VDK82414.1 - 1.6e-06 28.7 16.5 3.2e-06 27.7 6.3 3.5 1 1 1 2 2 2 1 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 Ubiquitin_4 PF18036.1 VDK82414.1 - 0.057 13.5 3.0 13 5.9 0.0 4.2 4 2 1 5 5 5 0 Ubiquitin-like domain Fe-S_biosyn PF01521.20 VDK82416.1 - 1.8e-18 66.8 0.0 2.5e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis RMI1_N PF08585.12 VDK82417.1 - 4.6e-20 72.3 8.2 1e-16 61.4 0.1 3.6 3 1 1 4 4 4 2 RecQ mediated genome instability protein SMN PF06003.12 VDK82417.1 - 3.2e-05 23.3 0.4 3.2e-05 23.3 0.4 2.7 2 1 1 3 3 3 1 Survival motor neuron protein (SMN) Tudor_2 PF18104.1 VDK82417.1 - 0.0021 17.7 0.0 0.005 16.5 0.0 1.7 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain Acetyltransf_1 PF00583.25 VDK82418.1 - 1.1e-09 38.6 0.0 1.4e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 VDK82418.1 - 1.3e-06 28.7 0.5 3.4e-06 27.3 0.4 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 VDK82418.1 - 2e-05 24.6 0.0 2.9e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 VDK82418.1 - 9.4e-05 22.8 0.0 0.00016 22.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 VDK82418.1 - 0.033 14.3 0.0 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase FR47 PF08445.10 VDK82418.1 - 0.034 14.1 0.0 0.086 12.8 0.0 1.6 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_3 PF13302.7 VDK82418.1 - 0.07 13.8 0.2 0.098 13.3 0.2 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain PRP21_like_P PF12230.8 VDK82425.1 - 1e-39 136.6 8.0 1.8e-39 135.9 8.0 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein ubiquitin PF00240.23 VDK82425.1 - 1.3e-12 47.3 0.0 4e-12 45.7 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 VDK82425.1 - 0.0062 16.3 0.0 0.026 14.3 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like TPR_8 PF13181.6 VDK82425.1 - 0.62 10.4 1.8 2.7 8.4 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Copine PF07002.16 VDK82426.1 - 4.8e-66 222.3 0.1 9.9e-66 221.3 0.1 1.6 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 VDK82426.1 - 7.3e-10 39.3 0.1 2.1e-09 37.8 0.1 1.8 1 0 0 1 1 1 1 vWA found in TerF C terminus LRR19-TM PF15176.6 VDK82428.1 - 0.00068 19.6 0.0 0.00084 19.3 0.0 1.2 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain PspB PF06667.12 VDK82428.1 - 0.0088 16.1 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Phage shock protein B DUF4381 PF14316.6 VDK82428.1 - 0.056 13.7 0.1 0.071 13.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Zn_peptidase_2 PF04298.12 VDK82428.1 - 0.08 12.3 0.0 0.093 12.1 0.0 1.1 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase Get5_bdg PF16843.5 VDK82429.1 - 0.037 13.5 0.0 0.076 12.5 0.0 1.5 1 0 0 1 1 1 0 Binding domain to Get4 on Get5, Golgi to ER traffic protein DUF2935 PF11155.8 VDK82429.1 - 0.047 14.0 0.0 0.18 12.1 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) FerA PF08165.11 VDK82429.1 - 0.076 13.0 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 FerA (NUC095) domain APG6_N PF17675.1 VDK82429.1 - 2.2 8.8 11.0 2.8 8.5 0.7 3.4 3 1 0 3 3 3 0 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 VDK82429.1 - 6.3 7.1 15.4 10 6.5 4.3 3.7 4 0 0 4 4 4 0 ABC transporter C-terminal domain Arf PF00025.21 VDK82432.1 - 6.2e-42 143.0 2.9 4e-29 101.3 0.5 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family SRPRB PF09439.10 VDK82432.1 - 4e-08 32.9 0.9 4.3e-05 23.0 0.0 2.3 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit Roc PF08477.13 VDK82432.1 - 1.8e-07 31.4 0.2 3.5e-07 30.5 0.2 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 VDK82432.1 - 8.3e-06 25.9 0.0 1.4e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 VDK82432.1 - 2.4e-05 23.7 1.4 0.0053 16.0 0.3 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 VDK82432.1 - 7.3e-05 22.4 0.1 0.00011 21.8 0.1 1.3 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 VDK82432.1 - 7.7e-05 22.1 0.5 0.00048 19.6 0.5 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 VDK82432.1 - 0.009 16.5 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter NitrOD1 PF18549.1 VDK82432.1 - 0.012 15.6 1.0 0.02 14.8 0.2 1.7 2 0 0 2 2 2 0 Nitrosopumilus output domain 1 AAA_14 PF13173.6 VDK82432.1 - 0.16 12.0 0.9 0.37 10.8 0.2 2.0 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 VDK82432.1 - 0.17 11.5 0.4 0.79 9.3 0.1 2.1 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain phage_tail_N PF08400.10 VDK82438.1 - 0.099 12.6 0.3 0.22 11.5 0.3 1.5 1 0 0 1 1 1 0 Prophage tail fibre N-terminal Destabilase PF05497.12 VDK82439.1 - 8e-22 77.8 14.2 9.1e-22 77.6 14.2 1.0 1 0 0 1 1 1 1 Destabilase CSN8_PSD8_EIF3K PF10075.9 VDK82440.1 - 4.8e-07 29.9 0.5 2.4e-06 27.6 0.2 2.0 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family zf-ANAPC11 PF12861.7 VDK82441.1 - 4e-32 110.1 11.0 6e-32 109.6 11.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 VDK82441.1 - 3.2e-21 75.4 15.7 5.7e-21 74.6 15.7 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 VDK82441.1 - 1.7e-05 25.1 18.5 0.00013 22.2 18.5 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 VDK82441.1 - 0.0013 18.6 13.6 0.0034 17.2 13.6 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK82441.1 - 0.45 10.5 14.6 1.2 9.1 14.6 1.8 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING-like PF08746.11 VDK82441.1 - 0.47 10.8 10.4 1 9.7 10.4 1.6 1 0 0 1 1 1 0 RING-like domain zf-Nse PF11789.8 VDK82441.1 - 0.98 9.3 8.2 2.2 8.1 8.2 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 VDK82441.1 - 1.5 8.6 12.6 9.1 6.1 12.6 2.2 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 VDK82441.1 - 2.3 8.1 17.5 14 5.6 17.5 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK82441.1 - 2.5 8.0 14.9 1.4 8.8 9.9 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Mitofilin PF09731.9 VDK82442.1 - 3.6e-120 402.7 32.0 4.7e-120 402.3 32.0 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Fapy_DNA_glyco PF01149.24 VDK82442.1 - 0.033 14.8 0.2 0.13 12.9 0.2 2.0 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase N-terminal domain DUF4366 PF14283.6 VDK82442.1 - 0.23 11.5 0.0 0.23 11.5 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) RNaseH_like PF04308.12 VDK82442.1 - 0.34 10.8 3.9 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease H-like Ntox28 PF15605.6 VDK82442.1 - 0.47 10.7 7.2 0.27 11.5 1.2 3.2 2 2 0 2 2 2 0 Bacterial toxin 28 7tm_1 PF00001.21 VDK82443.1 - 1e-66 225.0 9.7 1.5e-66 224.5 9.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK82443.1 - 8.8e-09 35.1 7.0 2.2e-08 33.8 7.0 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 VDK82443.1 - 6.6e-07 29.3 8.4 2.8e-06 27.3 5.2 2.7 2 1 1 3 3 3 1 Olfactory receptor 7TM_GPCR_Srx PF10328.9 VDK82443.1 - 5.4e-05 23.0 11.7 0.00011 22.0 11.7 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF621 PF04789.15 VDK82443.1 - 0.017 14.3 9.7 0.035 13.3 9.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF621) YtpI PF14007.6 VDK82443.1 - 0.04 14.0 6.9 1.4 9.1 0.0 3.4 2 1 1 3 3 3 0 YtpI-like protein Serpentine_r_xa PF03383.15 VDK82443.1 - 1.9 8.5 10.4 0.17 11.8 4.3 2.4 2 1 0 2 2 2 0 Caenorhabditis serpentine receptor-like protein, class xa DUF1700 PF08006.11 VDK82443.1 - 5 6.6 18.0 2 7.9 0.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1700) DUF5389 PF17364.2 VDK82443.1 - 6.9 6.8 8.6 17 5.6 0.1 3.3 3 1 0 3 3 3 0 Family of unknown function (DUF5389) DUF3671 PF12420.8 VDK82443.1 - 8.3 6.5 9.7 0.6 10.2 1.6 2.6 3 0 0 3 3 3 0 Protein of unknown function 7tm_1 PF00001.21 VDK82449.1 - 0.00017 21.0 17.9 0.00018 20.9 17.5 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srbc PF10316.9 VDK82449.1 - 0.0003 20.4 15.2 0.0003 20.4 15.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc RseC_MucC PF04246.12 VDK82449.1 - 0.034 14.1 1.2 0.1 12.6 0.0 2.4 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC DAO PF01266.24 VDK82450.1 - 4.1e-61 207.5 0.0 8.5e-61 206.5 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 VDK82450.1 - 0.00014 22.0 0.1 0.00034 20.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 VDK82450.1 - 0.0006 18.5 0.0 0.016 13.8 0.0 2.1 2 0 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) Thi4 PF01946.17 VDK82450.1 - 0.001 18.4 0.1 0.0017 17.7 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 VDK82450.1 - 0.0029 16.7 0.0 0.0048 16.0 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 VDK82450.1 - 0.0031 16.8 0.1 0.0066 15.7 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 VDK82450.1 - 0.15 11.3 0.0 13 4.9 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 VDK82450.1 - 0.26 10.1 0.0 0.37 9.6 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase TACC_C PF05010.14 VDK82451.1 - 2.1e-23 83.2 26.7 4e-22 79.0 26.2 2.8 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal SOAR PF16533.5 VDK82451.1 - 1.3 9.1 9.2 0.39 10.7 3.0 3.2 1 1 0 2 2 2 0 STIM1 Orai1-activating region DNA_pol3_a_NII PF11490.8 VDK82451.1 - 2.9 7.8 9.2 8.9 6.2 0.5 3.4 2 1 0 2 2 2 0 DNA polymerase III polC-type N-terminus II NYD-SP28_assoc PF14775.6 VDK82451.1 - 5.2 7.3 11.1 6.9 6.8 0.4 3.7 3 0 0 3 3 3 0 Sperm tail C-terminal domain RNA_POL_M_15KD PF02150.16 VDK82452.1 - 1.2e-13 50.6 4.6 3.9e-13 49.0 4.6 1.9 1 0 0 1 1 1 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 VDK82452.1 - 2.4e-12 46.5 7.5 2.3e-11 43.3 0.5 3.2 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Robl_LC7 PF03259.17 VDK82452.1 - 1.4e-07 31.2 0.1 2.5e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 Roadblock/LC7 domain Zn_ribbon_recom PF13408.6 VDK82452.1 - 0.00036 21.0 0.7 0.006 17.1 0.1 2.3 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain DZR PF12773.7 VDK82452.1 - 0.052 13.6 5.1 0.06 13.4 2.0 2.2 2 0 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.6 VDK82452.1 - 0.074 13.4 0.1 0.074 13.4 0.1 2.4 2 0 0 2 2 2 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.7 VDK82452.1 - 0.23 11.5 5.4 4.1 7.5 0.3 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-C4_Topoisom PF01396.19 VDK82452.1 - 4.4 7.2 7.7 0.35 10.7 1.3 2.2 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger RecR PF02132.15 VDK82452.1 - 7.2 6.3 8.4 32 4.2 3.6 3.0 2 1 1 3 3 3 0 RecR protein CpXC PF14353.6 VDK82452.1 - 9.6 6.3 8.4 3.1 7.9 0.6 2.7 1 1 2 3 3 3 0 CpXC protein vATP-synt_E PF01991.18 VDK82453.1 - 5.1e-66 221.9 9.7 5.8e-66 221.7 9.7 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit zf-CRD PF17979.1 VDK82453.1 - 0.15 12.2 2.0 4.4 7.4 0.0 2.1 1 1 0 2 2 2 0 Cysteine rich domain with multizinc binding regions Glutaminase PF04960.15 VDK82465.1 - 5.4e-31 107.8 0.0 7.9e-31 107.3 0.0 1.2 1 0 0 1 1 1 1 Glutaminase EF-hand_14 PF17959.1 VDK82465.1 - 1e-26 93.1 0.0 1.7e-26 92.4 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain Nsp1_C PF05064.13 VDK82466.1 - 3.1e-14 52.8 2.5 3.1e-14 52.8 2.5 2.3 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 VDK82466.1 - 1.4e-05 25.8 165.5 0.0076 17.1 16.4 8.2 1 1 6 7 7 7 3 Nucleoporin FG repeat region BLOC1_2 PF10046.9 VDK82466.1 - 0.11 12.8 10.2 0.96 9.8 1.3 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 VDK82466.1 - 2.4 7.0 12.5 0.084 11.7 0.7 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Bac_export_2 PF01312.19 VDK82466.1 - 8.7 5.4 10.6 0.45 9.7 4.3 2.1 2 1 1 3 3 3 0 FlhB HrpN YscU SpaS Family NPV_P10 PF05531.12 VDK82466.1 - 10 6.7 11.2 22 5.6 5.3 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein MFP2b PF12150.8 VDK82467.1 - 1.7e-164 547.1 0.0 2e-164 546.9 0.0 1.0 1 0 0 1 1 1 1 Cytosolic motility protein GP38 PF05268.11 VDK82467.1 - 0.002 17.8 0.0 0.81 9.3 0.0 2.1 2 0 0 2 2 2 2 Phage tail fibre adhesin Gp38 DUF3421 PF11901.8 VDK82467.1 - 0.007 16.3 0.1 0.077 13.0 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF3421) EGF_alliinase PF04863.13 VDK82467.1 - 0.079 13.4 0.2 0.23 11.9 0.2 1.7 1 0 0 1 1 1 0 Alliinase EGF-like domain PAN_1 PF00024.26 VDK82468.1 - 1.2e-19 70.1 40.6 1e-06 28.6 4.3 4.6 4 0 0 4 4 4 4 PAN domain Peptidase_M13_N PF05649.13 VDK82469.1 - 2.4e-79 267.8 2.3 3.9e-79 267.1 2.3 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 VDK82469.1 - 2.3e-74 249.4 0.8 2.3e-74 249.4 0.8 1.8 2 0 0 2 2 2 1 Peptidase family M13 Tetraspanin PF00335.20 VDK82475.1 - 2.1e-29 102.8 6.1 2.5e-29 102.6 6.1 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF2207 PF09972.9 VDK82475.1 - 0.0012 17.7 1.1 0.0012 17.7 1.1 1.4 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) Ceramidase PF05875.12 VDK82475.1 - 0.0021 17.5 0.9 0.0044 16.5 0.1 1.7 1 1 1 2 2 2 1 Ceramidase YrvL PF14184.6 VDK82475.1 - 0.0031 17.6 7.2 0.0031 17.6 7.2 1.8 2 0 0 2 2 2 1 Regulatory protein YrvL CD52 PF15116.6 VDK82475.1 - 0.036 14.1 0.1 0.036 14.1 0.1 2.2 3 0 0 3 3 2 0 CAMPATH-1 antigen Bacteriocin_IId PF09221.10 VDK82475.1 - 0.045 13.9 0.3 0.085 13.1 0.3 1.4 1 0 0 1 1 1 0 Bacteriocin class IId cyclical uberolysin-like Phage_holin_3_6 PF07332.11 VDK82475.1 - 0.13 12.3 5.5 0.87 9.6 3.1 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Claudin_2 PF13903.6 VDK82475.1 - 0.31 10.8 5.3 0.26 11.0 4.2 1.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction DUF2157 PF09925.9 VDK82475.1 - 0.71 9.7 11.8 0.038 13.8 2.6 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) DUF4131 PF13567.6 VDK82475.1 - 2.8 7.6 4.3 0.78 9.4 0.7 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) BTK PF00779.19 VDK82475.1 - 7.3 6.5 7.9 40 4.1 0.1 3.7 4 0 0 4 4 4 0 BTK motif UDPG_MGDP_dh_C PF03720.15 VDK82477.1 - 5.8e-06 26.7 0.9 0.34 11.3 0.3 3.2 1 1 2 3 3 3 3 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain MIT_C PF16565.5 VDK82477.1 - 0.051 13.6 0.4 12 5.9 0.1 2.6 1 1 1 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT Sushi PF00084.20 VDK82478.1 - 9.7e-08 32.5 0.6 0.0069 17.0 0.1 2.4 2 0 0 2 2 2 2 Sushi repeat (SCR repeat) tRNA-synt_1b PF00579.25 VDK82479.1 - 2.5e-19 69.7 0.0 2.7e-11 43.3 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) DUF2853 PF11015.8 VDK82479.1 - 0.1 13.3 0.3 0.38 11.4 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2853) zf-C2H2_4 PF13894.6 VDK82480.1 - 3.4e-15 55.4 39.7 3.1e-05 24.4 1.5 6.0 6 0 0 6 6 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK82480.1 - 8.1e-13 48.1 31.8 0.0029 18.0 1.6 5.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK82480.1 - 6.7e-11 42.1 27.5 0.0019 18.5 1.2 5.6 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 VDK82480.1 - 2.5e-10 40.4 23.8 0.031 14.6 0.2 5.6 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK82480.1 - 3.8e-09 36.3 28.8 0.00066 19.6 1.8 5.4 4 1 1 5 5 5 4 C2H2-type zinc finger Zn-C2H2_12 PF18112.1 VDK82480.1 - 0.001 19.5 0.6 0.001 19.5 0.6 4.7 5 0 0 5 5 5 1 Autophagy receptor zinc finger-C2H2 domain zf_Hakai PF18408.1 VDK82480.1 - 0.018 14.7 16.8 0.053 13.2 1.0 4.6 4 0 0 4 4 4 0 C2H2 Hakai zinc finger domain PX PF00787.24 VDK82480.1 - 0.038 14.0 0.8 0.072 13.1 0.4 1.7 1 1 0 1 1 1 0 PX domain zf-met PF12874.7 VDK82480.1 - 0.057 13.8 26.4 0.28 11.6 0.6 5.5 5 1 0 5 5 5 0 Zinc-finger of C2H2 type RuBisCO_large PF00016.20 VDK82480.1 - 0.061 12.5 0.1 0.073 12.2 0.1 1.1 1 0 0 1 1 1 0 Ribulose bisphosphate carboxylase large chain, catalytic domain BolA PF01722.18 VDK82480.1 - 0.23 11.7 4.0 0.16 12.3 1.1 2.1 1 1 1 2 2 2 0 BolA-like protein zf-C2HC_2 PF13913.6 VDK82480.1 - 0.27 11.2 17.7 1.8 8.6 0.1 5.8 6 1 0 6 6 5 0 zinc-finger of a C2HC-type Zn_Tnp_IS1595 PF12760.7 VDK82480.1 - 1.9 8.6 20.3 0.58 10.2 1.9 4.1 4 0 0 4 4 4 0 Transposase zinc-ribbon domain PHD_4 PF16866.5 VDK82480.1 - 5.5 7.2 15.3 1 9.5 1.4 3.5 2 1 0 3 3 3 0 PHD-finger CxC7 PF18866.1 VDK82480.1 - 6.5 7.0 11.0 0.64 10.2 0.2 3.4 3 1 0 4 4 4 0 CxC7 like cysteine cluster associated with KDZ transposases Zn-ribbon_8 PF09723.10 VDK82480.1 - 6.9 6.9 20.1 4.8 7.4 0.4 4.9 3 1 2 5 5 5 0 Zinc ribbon domain Aquarius_N PF16399.5 VDK82481.1 - 7.4e-236 785.0 5.7 1.4e-119 400.5 9.2 2.4 1 1 1 2 2 2 2 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 VDK82481.1 - 9.7e-28 97.1 0.0 4.9e-27 94.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 VDK82481.1 - 1.1e-27 97.4 0.3 2.3e-13 50.6 0.0 2.7 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 VDK82481.1 - 2.3e-08 34.5 0.0 1.1e-07 32.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 VDK82481.1 - 7e-06 25.9 0.0 0.0032 17.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 VDK82481.1 - 9.6e-06 25.7 0.8 2.9e-05 24.1 0.0 2.2 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 VDK82481.1 - 0.00021 21.1 0.0 0.00041 20.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 VDK82481.1 - 0.0028 17.2 0.0 0.011 15.3 0.0 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Parvo_NS1 PF01057.17 VDK82481.1 - 0.015 14.4 0.0 0.031 13.4 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA PF00004.29 VDK82481.1 - 0.015 15.7 0.0 0.039 14.4 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 VDK82481.1 - 0.023 14.5 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.6 VDK82481.1 - 0.026 14.8 0.1 0.23 11.7 0.0 2.5 2 1 1 3 3 2 0 AAA domain DnaB_C PF03796.15 VDK82481.1 - 0.032 13.6 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain RecA PF00154.21 VDK82481.1 - 0.038 13.5 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein DUF2075 PF09848.9 VDK82481.1 - 0.039 13.2 0.6 0.064 12.5 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TCTP PF00838.17 VDK82481.1 - 0.042 14.2 0.5 0.089 13.1 0.5 1.5 1 0 0 1 1 1 0 Translationally controlled tumour protein AAA_16 PF13191.6 VDK82481.1 - 0.042 14.2 0.0 0.13 12.6 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 VDK82481.1 - 0.044 13.2 0.0 0.093 12.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Viral_helicase1 PF01443.18 VDK82481.1 - 0.089 12.5 0.0 1.9 8.2 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 VDK82481.1 - 0.11 12.1 0.0 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF3987 PF13148.6 VDK82481.1 - 0.44 9.5 2.5 29 3.5 3.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) NPR2 PF06218.11 VDK82494.1 - 7.6e-79 265.5 8.1 4.6e-34 117.9 3.1 3.1 1 1 2 3 3 3 3 Nitrogen permease regulator 2 PIG-F PF06699.11 VDK82494.1 - 1.6e-18 67.5 3.5 3e-18 66.6 3.5 1.4 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F DUF2684 PF10885.8 VDK82494.1 - 0.002 18.2 0.2 0.0054 16.8 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2684) Afi1 PF07792.12 VDK82494.1 - 0.017 15.6 0.0 0.027 15.0 0.0 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking HTH_47 PF16221.5 VDK82494.1 - 0.066 12.8 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 winged helix-turn-helix NAD_Gly3P_dh_N PF01210.23 VDK82496.1 - 5.6e-17 62.2 0.6 1.9e-10 40.9 0.1 2.1 1 1 1 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Innexin PF00876.18 VDK82497.1 - 2.6e-97 326.3 8.2 6.5e-91 305.2 5.7 2.1 1 1 1 2 2 2 2 Innexin DUF3394 PF11874.8 VDK82497.1 - 0.0082 15.8 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3394) TA0956 PF11513.8 VDK82497.1 - 0.41 10.9 2.0 1.9 8.8 0.1 2.3 1 1 1 2 2 2 0 Thermoplasma acidophilum protein TA0956 ADK PF00406.22 VDK82498.1 - 2.2e-46 157.7 0.1 1.3e-24 87.0 0.0 2.6 3 0 0 3 3 3 2 Adenylate kinase AAA_17 PF13207.6 VDK82498.1 - 2.4e-30 105.7 0.3 6.8e-19 68.6 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 VDK82498.1 - 8.7e-07 29.5 0.2 0.0021 18.6 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 VDK82498.1 - 5.5e-05 23.4 0.0 1 9.5 0.0 3.7 2 1 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 VDK82498.1 - 0.0012 18.1 0.0 0.014 14.7 0.0 2.6 3 0 0 3 3 3 1 Zeta toxin AAA_5 PF07728.14 VDK82498.1 - 0.0025 17.8 0.0 1.1 9.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 VDK82498.1 - 0.0043 17.3 0.0 0.15 12.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain Dpy-30 PF05186.13 VDK82498.1 - 0.016 14.9 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Dpy-30 motif DUF5582 PF17819.1 VDK82498.1 - 0.042 14.3 3.3 0.062 13.8 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5582) AAA_22 PF13401.6 VDK82498.1 - 0.048 13.9 0.0 6.1 7.1 0.0 3.4 4 0 0 4 4 4 0 AAA domain Mg_chelatase PF01078.21 VDK82498.1 - 0.1 11.9 0.0 5.6 6.3 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF902 PF06001.13 VDK82499.1 - 0.17 12.4 1.1 4.3 7.9 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF902) WW PF00397.26 VDK82501.1 - 3.8e-13 49.3 1.9 5.3e-08 32.8 1.3 2.6 2 0 0 2 2 2 2 WW domain MOLO1 PF17175.4 VDK82503.1 - 0.015 15.4 0.9 0.07 13.3 0.7 2.2 2 1 0 2 2 2 0 Modulator of levamisole receptor-1 CUB PF00431.20 VDK82511.1 - 4e-71 236.4 0.8 1.2e-18 67.4 0.0 5.7 5 1 1 6 6 6 5 CUB domain Ldl_recept_a PF00057.18 VDK82511.1 - 0.028 14.6 4.9 0.07 13.4 4.9 1.8 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A PgaD PF13994.6 VDK82511.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 PgaD-like protein SPRY PF00622.28 VDK82512.1 - 1.1e-25 90.0 0.3 2.1e-25 89.1 0.3 1.5 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 VDK82512.1 - 3.5e-12 46.4 0.0 5.9e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 VDK82512.1 - 0.055 13.5 0.0 0.16 12.0 0.0 1.9 1 0 0 1 1 1 0 LisH Dus PF01207.17 VDK82513.1 - 8.1e-51 173.0 0.5 4.4e-50 170.5 0.5 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) dsrm PF00035.26 VDK82513.1 - 1.1e-07 32.5 0.4 6.6e-07 29.9 0.1 2.2 2 0 0 2 2 2 1 Double-stranded RNA binding motif His_biosynth PF00977.21 VDK82513.1 - 0.019 14.4 0.2 0.082 12.4 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein Zf_RING PF16744.5 VDK82513.1 - 0.023 14.8 1.1 0.31 11.2 0.1 2.7 3 0 0 3 3 3 0 KIAA1045 RING finger PEP_mutase PF13714.6 VDK82513.1 - 0.035 13.6 0.0 0.2 11.1 0.0 2.1 1 1 1 2 2 2 0 Phosphoenolpyruvate phosphomutase DND1_DSRM PF14709.7 VDK82513.1 - 0.51 10.6 1.7 2.7 8.3 0.7 2.6 2 1 0 2 2 2 0 double strand RNA binding domain from DEAD END PROTEIN 1 Peptidase_M1 PF01433.20 VDK82515.1 - 3.8e-49 167.2 0.4 5.7e-49 166.6 0.4 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 VDK82515.1 - 1.5e-24 86.2 0.0 3e-24 85.3 0.0 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 VDK82515.1 - 1.4e-19 71.0 0.0 3.5e-19 69.7 0.0 1.6 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain RNA_lig_T4_1 PF09511.10 VDK82515.1 - 0.029 14.2 0.0 4.4 7.1 0.0 2.4 1 1 1 2 2 2 0 RNA ligase NatB_MDM20 PF09797.9 VDK82515.1 - 0.046 12.7 0.1 0.068 12.1 0.1 1.2 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit Zn_peptidase PF04228.13 VDK82515.1 - 0.16 11.4 0.0 1.1 8.7 0.0 2.0 2 0 0 2 2 2 0 Putative neutral zinc metallopeptidase Methyltransf_16 PF10294.9 VDK82518.1 - 1.3e-29 103.2 0.0 1.5e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 VDK82518.1 - 2.3e-07 31.4 0.0 5.6e-07 30.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK82518.1 - 5.2e-07 30.3 0.0 9.1e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK82518.1 - 6.2e-07 29.4 0.0 8.5e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK82518.1 - 1.1e-06 28.5 0.0 1.6e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK82518.1 - 7.3e-06 26.5 0.0 1.4e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 VDK82518.1 - 0.00072 19.0 0.0 0.00096 18.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 VDK82518.1 - 0.0017 17.8 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 VDK82518.1 - 0.0075 15.8 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 VDK82518.1 - 0.0084 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW DREV PF05219.12 VDK82518.1 - 0.01 15.0 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Cons_hypoth95 PF03602.15 VDK82518.1 - 0.023 14.3 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CMAS PF02353.20 VDK82518.1 - 0.15 11.3 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 VDK82518.1 - 0.17 12.0 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 VDK82518.1 - 0.19 11.5 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) bZIP_2 PF07716.15 VDK82519.1 - 3.6e-11 42.9 12.3 3.6e-11 42.9 12.3 3.2 4 0 0 4 4 4 1 Basic region leucine zipper Sas10_Utp3 PF04000.15 VDK82519.1 - 1.9e-09 38.0 3.1 3.1e-09 37.3 0.0 2.8 3 0 0 3 3 3 1 Sas10/Utp3/C1D family bZIP_1 PF00170.21 VDK82519.1 - 0.0069 16.5 8.0 0.0069 16.5 8.0 3.2 3 0 0 3 3 3 1 bZIP transcription factor Ribosomal_L50 PF10501.9 VDK82523.1 - 1.8e-12 47.4 0.1 2.4e-12 46.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal subunit 39S RPA_C PF08784.11 VDK82524.1 - 0.0016 19.1 0.0 0.0038 17.9 0.0 1.6 1 0 0 1 1 1 1 Replication protein A C terminal UQ_con PF00179.26 VDK82525.1 - 7.4e-33 113.1 0.6 1.2e-32 112.5 0.4 1.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK82525.1 - 2e-05 24.3 0.0 3.1e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 VDK82525.1 - 0.047 14.0 0.4 0.073 13.4 0.3 1.6 1 1 0 1 1 1 0 RWD domain Prok-E2_A PF14457.6 VDK82525.1 - 0.06 13.0 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family A UEV PF05743.13 VDK82525.1 - 0.092 12.6 0.2 0.21 11.5 0.2 1.5 1 1 0 1 1 1 0 UEV domain zf-CCCH PF00642.24 VDK82526.1 - 2.2e-16 59.3 2.6 1.9e-07 30.8 0.3 2.7 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK82526.1 - 1.3e-11 44.1 4.2 1.8e-05 24.6 0.4 2.6 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 VDK82526.1 - 1.7e-08 34.1 8.1 0.00045 20.0 4.1 3.1 2 1 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 VDK82526.1 - 0.002 18.5 8.0 0.036 14.5 0.1 2.8 3 0 0 3 3 3 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 VDK82526.1 - 0.098 13.4 1.6 15 6.3 0.2 2.5 2 0 0 2 2 2 0 Torus domain DZF PF07528.14 VDK82527.1 - 1.5e-51 175.4 0.1 1.5e-51 175.4 0.1 1.7 2 0 0 2 2 2 1 DZF domain zf-met PF12874.7 VDK82527.1 - 1.7e-20 72.7 19.5 5.8e-07 29.7 1.8 3.9 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK82527.1 - 2e-15 56.6 21.4 1e-05 25.7 2.9 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDK82527.1 - 4.2e-05 23.8 19.6 0.5 10.7 3.6 4.3 3 1 1 4 4 4 3 C2H2 type zinc-finger (2 copies) LAL_C2 PF18603.1 VDK82527.1 - 0.0023 18.1 1.4 0.013 15.7 1.4 2.3 1 0 0 1 1 1 1 L-amino acid ligase C-terminal domain 2 zf-C2H2_4 PF13894.6 VDK82527.1 - 0.19 12.6 11.5 4.6 8.3 0.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger DUF3449 PF11931.8 VDK82527.1 - 0.24 11.2 0.1 0.24 11.2 0.1 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3449) zf-C2H2 PF00096.26 VDK82527.1 - 0.35 11.4 18.5 3 8.5 1.8 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-DBF PF07535.12 VDK82527.1 - 0.48 10.6 17.4 3.2 7.9 3.0 3.5 3 0 0 3 3 3 0 DBF zinc finger zf-U1 PF06220.12 VDK82527.1 - 0.82 9.5 17.4 2.2 8.1 2.0 3.5 3 0 0 3 3 3 0 U1 zinc finger Ribosomal_L34e PF01199.18 VDK82528.1 - 5.6e-38 129.1 6.3 7.2e-38 128.8 6.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e Proteasome PF00227.26 VDK82529.1 - 8.5e-34 116.7 0.0 1e-33 116.4 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF3912 PF13051.6 VDK82529.1 - 0.12 12.7 0.2 0.41 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3912) V-ATPase_C PF03223.15 VDK82530.1 - 2.1e-54 185.4 5.1 2.5e-54 185.1 5.1 1.0 1 0 0 1 1 1 1 V-ATPase subunit C MannoseP_isomer PF01050.18 VDK82530.1 - 0.057 13.3 0.2 11 5.9 0.0 2.2 2 0 0 2 2 2 0 Mannose-6-phosphate isomerase Csm2_III-A PF03750.13 VDK82531.1 - 0.1 13.5 0.8 0.45 11.4 0.2 2.1 1 1 1 2 2 2 0 Csm2 Type III-A UPF0184 PF03670.13 VDK82532.1 - 7.1e-05 23.1 2.0 7.1e-05 23.1 2.0 2.6 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0184) PKK PF12474.8 VDK82532.1 - 0.016 15.4 5.9 0.016 15.4 5.9 2.5 3 0 0 3 3 3 0 Polo kinase kinase Rootletin PF15035.6 VDK82532.1 - 0.044 13.8 9.6 0.088 12.8 9.6 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Cortex-I_coil PF09304.10 VDK82532.1 - 9.8 6.5 11.2 2.5 8.4 3.1 2.6 3 0 0 3 3 3 0 Cortexillin I, coiled coil Radical_SAM_C PF16199.5 VDK82535.1 - 3.8e-31 106.9 0.2 1.2e-30 105.4 0.1 2.0 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 VDK82535.1 - 2.3e-22 80.2 0.2 1.2e-20 74.5 0.1 2.6 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 VDK82535.1 - 8.6e-11 42.1 0.1 1.8e-10 41.0 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 VDK82535.1 - 2.7e-05 24.1 0.1 6.7e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 VDK82535.1 - 0.0027 18.1 0.0 0.0053 17.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AP_endonuc_2 PF01261.24 VDK82535.1 - 0.16 11.4 0.0 0.35 10.3 0.0 1.6 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel zf-met PF12874.7 VDK82537.1 - 3.3e-06 27.3 0.6 1.4e-05 25.3 0.6 2.1 1 0 0 1 1 1 1 Zinc-finger of C2H2 type NTP_transf_2 PF01909.23 VDK82537.1 - 0.00022 21.5 0.0 0.00073 19.8 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain RRM_1 PF00076.22 VDK82537.1 - 0.0008 19.2 0.1 0.0022 17.8 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.8 VDK82537.1 - 0.0021 18.3 0.3 0.006 16.8 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding RL PF17797.1 VDK82537.1 - 0.021 14.8 0.0 0.05 13.6 0.0 1.6 1 0 0 1 1 1 0 RL domain zf-U1 PF06220.12 VDK82537.1 - 0.073 12.9 1.4 1.1 9.1 0.6 2.7 2 0 0 2 2 2 0 U1 zinc finger Cmc1 PF08583.10 VDK82538.1 - 0.0026 17.7 2.7 0.0075 16.3 2.7 1.9 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 VDK82538.1 - 0.68 10.0 3.8 17 5.5 0.0 3.0 3 0 0 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, FMO-like PF00743.19 VDK82540.1 - 3.4e-174 580.2 0.0 4.4e-174 579.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 VDK82540.1 - 4.3e-19 68.9 0.0 8.4e-15 54.8 0.0 3.0 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 VDK82540.1 - 1.9e-10 40.5 0.0 1.3e-09 37.7 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 VDK82540.1 - 3.3e-07 30.5 0.0 7.9e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 VDK82540.1 - 1.3e-06 27.8 0.1 6.2e-05 22.3 0.0 3.1 4 0 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 VDK82540.1 - 0.00013 21.3 0.2 0.0003 20.1 0.2 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 VDK82540.1 - 0.0014 18.6 0.0 0.0052 16.8 0.0 2.0 1 1 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 VDK82540.1 - 0.0039 16.8 0.5 1.2 8.6 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 VDK82540.1 - 0.0081 15.3 0.4 0.013 14.6 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 VDK82540.1 - 0.011 15.1 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 VDK82540.1 - 0.017 13.8 0.5 0.028 13.2 0.5 1.3 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 VDK82540.1 - 0.1 11.9 0.1 0.19 11.0 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mak10 PF04112.13 VDK82548.1 - 3.1e-25 88.6 2.7 1.6e-18 66.8 0.7 2.6 1 1 1 2 2 2 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Ribosomal_S2 PF00318.20 VDK82549.1 - 5.2e-36 123.9 1.8 1.6e-18 66.8 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 Phage_holin_T PF11031.8 VDK82549.1 - 0.056 12.9 0.0 0.096 12.2 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage T holin Apt1 PF10351.9 VDK82551.1 - 2.3e-82 277.4 8.2 1.6e-77 261.4 8.2 2.7 1 1 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 VDK82551.1 - 2.3e-29 102.5 0.0 5.2e-29 101.4 0.0 1.7 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 VDK82551.1 - 4.2e-06 26.8 0.2 1.6e-05 24.9 0.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF2405) Dpy-30 PF05186.13 VDK82552.1 - 1.2e-20 72.9 1.3 1.7e-20 72.4 1.3 1.2 1 0 0 1 1 1 1 Dpy-30 motif Borrelia_P83 PF05262.11 VDK82552.1 - 0.044 12.3 9.5 0.054 12.0 9.5 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Zip PF02535.22 VDK82552.1 - 0.36 10.0 1.4 0.34 10.1 1.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 VDK82552.1 - 0.62 10.1 3.7 0.68 10.0 3.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 VDK82552.1 - 1.6 7.4 8.0 1.6 7.4 8.0 1.2 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 VDK82552.1 - 3.5 5.6 8.5 3.4 5.7 8.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4050 PF13259.6 VDK82552.1 - 3.6 7.9 10.5 25 5.1 10.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) RRM_1 PF00076.22 VDK82553.1 - 1.3e-09 37.8 0.2 2.1e-05 24.2 0.1 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK82553.1 - 0.03 14.4 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif zf-CCHC PF00098.23 VDK82553.1 - 0.05 13.7 1.8 0.1 12.7 1.8 1.6 1 0 0 1 1 1 0 Zinc knuckle Med16 PF11635.8 VDK82553.1 - 0.42 8.5 0.8 0.79 7.6 0.7 1.3 1 1 0 1 1 1 0 Mediator complex subunit 16 Laminin_G_1 PF00054.23 VDK82557.1 - 0.17 12.1 0.0 0.2 11.9 0.0 1.1 1 0 0 1 1 1 0 Laminin G domain CCDC24 PF15669.5 VDK82557.1 - 0.68 9.8 5.6 0.71 9.7 5.6 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Frag1 PF10277.9 VDK82558.1 - 1.1e-19 70.9 17.2 1.4e-19 70.5 17.2 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Ephrin PF00812.17 VDK82559.1 - 3.9e-29 101.4 0.0 7e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 Ephrin DUF4228 PF14009.6 VDK82559.1 - 0.022 15.2 0.1 0.031 14.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF1283 PF06932.11 VDK82559.1 - 0.33 11.2 2.8 0.62 10.3 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1283) KCT2 PF17818.1 VDK82561.1 - 5.5e-09 36.4 1.8 1.6e-08 34.9 0.3 1.8 1 1 1 2 2 2 1 Keratinocyte-associated gene product Peptidase_M16_C PF05193.21 VDK82563.1 - 4.4e-08 33.4 0.0 7.6e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 VDK82563.1 - 9.3e-08 32.2 0.0 1.6e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) LIM PF00412.22 VDK82569.1 - 2.5e-26 91.6 25.6 4.5e-14 52.4 10.6 2.1 2 0 0 2 2 2 2 LIM domain DUF627 PF04781.12 VDK82569.1 - 0.0095 15.9 0.2 0.019 15.0 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF627) Myotub-related PF06602.14 VDK82570.1 - 5e-76 255.9 0.0 1.4e-74 251.2 0.0 2.3 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain SBF2 PF12335.8 VDK82570.1 - 3e-70 236.4 1.0 4.9e-70 235.7 1.0 1.3 1 0 0 1 1 1 1 Myotubularin protein DENN PF02141.21 VDK82570.1 - 2.6e-36 125.3 2.2 6.4e-36 124.0 2.2 1.7 1 0 0 1 1 1 1 DENN (AEX-3) domain GRAM PF02893.20 VDK82570.1 - 1.2e-13 50.9 0.8 2.5e-11 43.4 0.2 3.7 3 1 0 3 3 3 1 GRAM domain PH PF00169.29 VDK82570.1 - 8e-13 48.8 0.0 1.8e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 PH domain uDENN PF03456.18 VDK82570.1 - 1.3e-09 38.7 0.0 3.4e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 uDENN domain C1_1 PF00130.22 VDK82570.1 - 3e-06 27.0 5.6 6.4e-06 26.0 5.6 1.6 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PH_11 PF15413.6 VDK82570.1 - 7e-06 26.4 0.1 2.5e-05 24.6 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 VDK82570.1 - 1.2e-05 25.4 0.1 3.2e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain dDENN PF03455.19 VDK82570.1 - 5.9e-05 23.0 1.8 0.00024 21.0 1.8 2.2 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 VDK82570.1 - 0.00031 20.7 0.1 0.00097 19.1 0.1 1.8 1 0 0 1 1 1 1 Stabilization of polarity axis FYVE PF01363.21 VDK82570.1 - 0.73 10.0 6.8 1.9 8.7 6.8 1.7 1 0 0 1 1 1 0 FYVE zinc finger DUF563 PF04577.14 VDK82571.1 - 0.00027 21.1 0.0 0.00052 20.2 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF563) TMEMspv1-c74-12 PF11044.8 VDK82572.1 - 0.0075 16.2 2.2 0.038 14.0 0.9 2.4 2 0 0 2 2 2 1 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF1218 PF06749.12 VDK82572.1 - 0.09 13.3 7.1 0.12 13.0 2.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) DUF563 PF04577.14 VDK82573.1 - 3.8e-15 56.6 0.2 4.6e-14 53.0 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF563) BAH PF01426.18 VDK82588.1 - 1.3e-24 86.4 0.1 9.4e-17 61.0 0.0 2.4 2 0 0 2 2 2 2 BAH domain MTA_R1 PF17226.2 VDK82588.1 - 1.7e-21 76.1 2.8 6.3e-21 74.3 2.8 2.1 1 0 0 1 1 1 1 MTA R1 domain ELM2 PF01448.24 VDK82588.1 - 5.2e-13 49.5 2.3 5.9e-13 49.4 0.1 2.4 3 0 0 3 3 3 1 ELM2 domain Myb_DNA-binding PF00249.31 VDK82588.1 - 1.1e-07 31.9 0.1 2.5e-07 30.8 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain GATA PF00320.27 VDK82588.1 - 2.1e-05 24.0 3.2 4.1e-05 23.1 3.2 1.5 1 0 0 1 1 1 1 GATA zinc finger Myb_DNA-bind_7 PF15963.5 VDK82588.1 - 0.023 14.6 0.4 0.065 13.1 0.4 1.7 1 0 0 1 1 1 0 Myb DNA-binding like COG7 PF10191.9 VDK82589.1 - 4.6e-11 41.7 0.3 1.8e-10 39.8 0.0 1.9 1 1 1 2 2 2 1 Golgi complex component 7 (COG7) SprT-like PF10263.9 VDK82590.1 - 3.5e-28 97.7 0.0 6.7e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 SprT-like family PRP21_like_P PF12230.8 VDK82590.1 - 0.0044 16.9 0.1 0.0078 16.1 0.1 1.4 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein zf-WRNIP1_ubi PF18279.1 VDK82590.1 - 0.015 15.9 2.0 0.043 14.4 2.0 1.8 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf_UBZ PF18439.1 VDK82590.1 - 0.027 14.0 0.1 0.059 13.0 0.1 1.6 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger WLM PF08325.10 VDK82590.1 - 0.05 13.7 0.5 0.29 11.2 0.1 2.1 2 0 0 2 2 2 0 WLM domain CRM1_C PF08767.11 VDK82591.1 - 2e-107 359.1 7.1 2e-107 359.1 7.1 3.5 4 1 1 5 5 5 1 CRM1 C terminal Xpo1 PF08389.12 VDK82591.1 - 1.9e-37 128.6 1.9 1.9e-37 128.6 1.9 5.8 6 1 0 6 6 6 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 VDK82591.1 - 5.3e-35 118.9 3.0 2.6e-34 116.7 3.0 2.3 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 VDK82591.1 - 2.7e-30 104.2 1.4 3.6e-29 100.6 0.9 3.0 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 VDK82591.1 - 2.7e-19 68.4 1.9 6.8e-19 67.1 1.9 1.8 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 VDK82591.1 - 4.5e-11 42.5 1.2 1.9e-10 40.5 0.2 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain MOZART2 PF12926.7 VDK82591.1 - 0.43 10.2 2.3 5.9 6.6 0.0 3.0 3 0 0 3 3 3 0 Mitotic-spindle organizing gamma-tubulin ring associated GCP_N_terminal PF17681.1 VDK82592.1 - 7.7e-26 91.4 0.1 9.9e-26 91.1 0.1 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 VDK82592.1 - 0.0017 17.9 1.4 0.0027 17.3 0.5 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal SAND PF01342.21 VDK82594.1 - 2.3e-22 78.5 0.1 4.5e-22 77.6 0.1 1.5 1 0 0 1 1 1 1 SAND domain AA_permease PF00324.21 VDK82596.1 - 7e-60 203.0 29.9 9.7e-58 195.9 29.9 2.1 1 1 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 VDK82596.1 - 1.9e-24 86.5 2.6 5e-09 35.7 0.0 4.1 3 1 1 4 4 4 4 Solute carrier family 12 Bac_GH3_C PF18034.1 VDK82596.1 - 0.0016 18.2 0.0 0.0041 16.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial Glycosyl hydrolase family 3 C-terminal domain PX PF00787.24 VDK82596.1 - 0.089 12.8 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 PX domain BTB PF00651.31 VDK82597.1 - 1.1e-15 57.8 0.0 7e-10 39.1 0.0 2.7 2 0 0 2 2 2 2 BTB/POZ domain BACK PF07707.15 VDK82597.1 - 0.03 14.4 0.5 6.8 6.9 0.1 3.2 3 0 0 3 3 3 0 BTB And C-terminal Kelch DUF4370 PF14290.6 VDK82597.1 - 0.094 12.6 0.2 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4370) UAA PF08449.11 VDK82602.1 - 5.4e-58 196.6 19.6 8.1e-58 196.0 19.6 1.3 1 0 0 1 1 1 1 UAA transporter family WD40 PF00400.32 VDK82602.1 - 1.1e-27 95.6 19.8 1.2e-05 26.0 0.0 9.4 10 0 0 10 10 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK82602.1 - 4.3e-22 78.2 0.4 0.0017 18.6 0.0 8.9 4 3 6 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 VDK82602.1 - 1.3e-16 60.9 1.6 2.7e-16 59.8 1.6 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family EamA PF00892.20 VDK82602.1 - 1.3e-12 48.1 12.1 6.3e-07 29.6 8.8 2.6 2 0 0 2 2 2 2 EamA-like transporter family Ge1_WD40 PF16529.5 VDK82602.1 - 7e-08 31.8 8.9 0.0043 16.1 0.0 7.1 3 1 3 8 8 8 2 WD40 region of Ge1, enhancer of mRNA-decapping protein TPT PF03151.16 VDK82602.1 - 1.9e-06 27.5 10.5 4e-06 26.4 10.5 1.4 1 0 0 1 1 1 1 Triose-phosphate Transporter family eIF2A PF08662.11 VDK82602.1 - 2e-06 27.8 0.7 0.0037 17.2 0.1 4.4 4 2 1 5 5 5 1 Eukaryotic translation initiation factor eIF2A Gmad1 PF10647.9 VDK82602.1 - 7.8e-06 25.8 4.2 0.0013 18.6 0.0 3.4 2 1 2 4 4 4 2 Lipoprotein LpqB beta-propeller domain Utp21 PF04192.12 VDK82602.1 - 0.0019 17.7 1.7 0.0031 17.1 1.7 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain Nup160 PF11715.8 VDK82602.1 - 0.0019 16.9 8.2 0.0046 15.7 1.9 3.2 2 1 0 2 2 2 1 Nucleoporin Nup120/160 Utp13 PF08625.11 VDK82602.1 - 0.053 13.4 6.4 0.18 11.7 6.4 1.9 1 1 0 1 1 1 0 Utp13 specific WD40 associated domain DUF1513 PF07433.11 VDK82602.1 - 0.062 12.4 2.1 1.4 8.0 0.3 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1513) T-box PF00907.22 VDK82603.1 - 1.6e-62 211.0 0.2 2.2e-62 210.6 0.2 1.1 1 0 0 1 1 1 1 T-box Homeodomain PF00046.29 VDK82604.1 - 4.2e-14 52.1 13.7 3.2e-09 36.5 2.0 2.5 2 0 0 2 2 2 2 Homeodomain TMEM251 PF15190.6 VDK82611.1 - 0.032 14.2 0.2 0.065 13.2 0.2 1.5 1 1 0 1 1 1 0 Transmembrane protein 251 TAF6_C PF07571.13 VDK82612.1 - 8.4e-24 83.7 0.1 1.6e-23 82.8 0.1 1.5 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 VDK82612.1 - 2.1e-14 53.4 0.1 4.7e-14 52.3 0.1 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) SPC25 PF06703.11 VDK82613.1 - 2.8e-42 144.3 0.1 3.4e-42 144.0 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) TTRAP PF14203.6 VDK82613.1 - 0.04 13.9 0.1 0.38 10.8 0.1 2.2 1 1 0 1 1 1 0 Putative tranposon-transfer assisting protein zf-C2H2 PF00096.26 VDK82615.1 - 3.8e-13 49.1 29.7 0.00045 20.5 0.5 5.6 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK82615.1 - 1.7e-12 47.0 29.5 0.0035 18.0 3.1 5.6 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK82615.1 - 3e-09 36.9 34.4 0.0033 17.8 3.3 6.9 7 0 0 7 7 7 4 Zinc-finger double domain zf-met PF12874.7 VDK82615.1 - 1.6e-06 28.3 21.6 0.0019 18.5 0.1 5.4 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-Di19 PF05605.12 VDK82615.1 - 8.3e-06 26.0 22.1 0.0018 18.5 4.4 3.6 3 1 1 4 4 4 3 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 VDK82615.1 - 1.3e-05 25.0 28.3 0.01 15.8 0.4 6.0 5 1 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK82615.1 - 0.0016 18.6 20.5 0.051 13.9 0.0 5.1 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDK82615.1 - 0.032 14.5 19.7 1 9.7 0.8 4.6 2 2 3 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-C2H2_8 PF15909.5 VDK82615.1 - 0.081 13.2 9.5 0.11 12.9 1.2 2.7 2 1 1 3 3 3 0 C2H2-type zinc ribbon Molybdop_Fe4S4 PF04879.16 VDK82615.1 - 0.15 12.1 1.4 0.29 11.2 0.2 2.1 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain GAGA PF09237.11 VDK82615.1 - 0.83 9.5 0.0 0.83 9.5 0.0 3.9 2 2 3 5 5 5 0 GAGA factor zf-H2C2_5 PF13909.6 VDK82615.1 - 1.8 8.4 6.9 5.5 6.8 3.9 3.1 2 1 0 2 2 2 0 C2H2-type zinc-finger domain CpXC PF14353.6 VDK82615.1 - 2.7 8.1 10.1 15 5.7 0.8 3.4 2 1 1 3 3 3 0 CpXC protein zf-MYST PF17772.1 VDK82615.1 - 8.4 6.1 9.3 0.52 10.0 0.1 3.3 4 0 0 4 4 4 0 MYST family zinc finger domain DZR PF12773.7 VDK82615.1 - 9.8 6.3 11.6 0.88 9.7 3.2 2.9 2 2 0 2 2 2 0 Double zinc ribbon PTPA PF03095.15 VDK82616.1 - 3.2e-111 371.6 0.0 3.7e-111 371.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Nup35_RRM_2 PF14605.6 VDK82616.1 - 0.23 11.5 0.5 1.2 9.2 0.0 2.3 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif AbiJ_NTD5 PF18865.1 VDK82617.1 - 0.008 16.0 0.1 0.02 14.7 0.1 1.8 1 0 0 1 1 1 1 AbiJ N-terminal domain 5 F-box-like PF12937.7 VDK82618.1 - 0.008 16.1 1.7 2.4 8.1 0.6 2.6 3 0 0 3 3 3 2 F-box-like F-box PF00646.33 VDK82618.1 - 0.11 12.5 0.5 12 5.9 0.0 2.5 2 0 0 2 2 2 0 F-box domain AAA_12 PF13087.6 VDK82621.1 - 8.1e-43 146.4 0.1 1.5e-42 145.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain Dna2 PF08696.11 VDK82621.1 - 1.8e-39 135.6 0.1 3.4e-39 134.8 0.1 1.5 1 0 0 1 1 1 1 DNA replication factor Dna2 Cas_Cas4 PF01930.17 VDK82621.1 - 1e-07 32.2 0.0 3.4e-05 24.0 0.0 2.7 1 1 1 2 2 2 2 Domain of unknown function DUF83 Csa1 PF06023.12 VDK82621.1 - 0.00067 19.1 0.2 0.0042 16.5 0.0 2.2 3 0 0 3 3 3 1 CRISPR-associated exonuclease Csa1 UvrD_C_2 PF13538.6 VDK82621.1 - 0.0057 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 VDK82621.1 - 0.012 15.3 0.1 0.044 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 VDK82621.1 - 0.041 13.7 0.2 2.8 7.7 0.0 2.5 2 1 1 3 3 3 0 AAA domain Voltage_CLC PF00654.20 VDK82625.1 - 4.5e-74 249.8 29.3 4.5e-74 249.8 29.3 1.9 1 1 1 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 VDK82625.1 - 9.8e-06 25.9 0.1 0.062 13.8 0.0 3.3 3 0 0 3 3 3 2 CBS domain SQS_PSY PF00494.19 VDK82628.1 - 5.7e-16 58.8 0.1 6.4e-16 58.6 0.1 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase MiaE PF06175.11 VDK82628.1 - 0.037 13.6 0.1 0.041 13.5 0.1 1.2 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) UPF0259 PF06790.11 VDK82628.1 - 0.15 11.9 0.2 0.16 11.7 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0259) CBM_14 PF01607.24 VDK82632.1 - 1.1e-51 172.8 75.3 6.5e-10 39.0 4.7 6.2 6 0 0 6 6 6 6 Chitin binding Peritrophin-A domain Miga PF10265.9 VDK82633.1 - 1.9e-112 377.0 1.9 1.9e-112 377.0 1.9 3.4 2 2 1 4 4 4 1 Mitoguardin SURF6 PF04935.12 VDK82633.1 - 5.6e-34 117.7 54.8 5.6e-34 117.7 54.8 2.8 2 1 1 3 3 3 1 Surfeit locus protein 6 I-set PF07679.16 VDK82636.1 - 1.1e-293 948.4 6.5 5.2e-18 64.9 0.0 21.4 21 0 0 21 21 21 21 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK82636.1 - 1.8e-257 832.7 35.4 2.1e-14 53.9 0.0 21.3 21 0 0 21 21 21 21 Immunoglobulin domain Ig_2 PF13895.6 VDK82636.1 - 5.5e-186 603.4 18.6 6.1e-11 42.5 0.0 21.4 16 4 5 21 21 21 20 Immunoglobulin domain ig PF00047.25 VDK82636.1 - 4.9e-145 472.1 12.4 9.2e-09 35.4 0.0 21.9 21 1 0 21 21 21 21 Immunoglobulin domain V-set PF07686.17 VDK82636.1 - 1.3e-51 173.3 40.6 0.15 12.2 0.0 30.0 20 14 3 23 23 23 12 Immunoglobulin V-set domain Ig_5 PF16681.5 VDK82636.1 - 3.1e-44 149.3 0.0 0.015 15.6 0.0 19.1 18 0 0 18 18 18 7 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 VDK82636.1 - 5.4e-42 141.8 16.6 0.017 15.2 0.0 17.9 19 0 0 19 19 19 12 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 VDK82636.1 - 1.8e-41 139.5 0.0 0.1 12.2 0.0 18.1 18 0 0 18 18 18 8 Immunoglobulin domain EGF_CA PF07645.15 VDK82636.1 - 6.1e-31 106.4 71.2 2.1e-08 34.2 6.7 7.2 8 0 0 8 8 6 5 Calcium-binding EGF domain Ig_4 PF16680.5 VDK82636.1 - 4.5e-30 103.7 0.6 0.54 10.6 0.0 18.0 17 0 0 17 17 17 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 VDK82636.1 - 3.4e-17 62.3 0.0 12 6.1 0.0 15.1 17 0 0 17 17 17 0 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 VDK82636.1 - 1.1e-14 54.6 3.5 0.014 15.6 0.0 9.8 12 0 0 12 12 10 3 Natural killer cell receptor 2B4 Ig_C17orf99 PF17736.1 VDK82636.1 - 8.2e-10 38.6 7.3 11 6.1 0.0 14.1 19 2 0 19 19 17 0 C17orf99 Ig domain EGF PF00008.27 VDK82636.1 - 0.0021 18.3 53.3 0.2 12.0 5.0 7.1 5 1 0 5 5 5 3 EGF-like domain EGF_3 PF12947.7 VDK82636.1 - 0.0024 18.0 3.8 0.0024 18.0 3.8 6.2 4 1 1 5 5 5 2 EGF domain cEGF PF12662.7 VDK82636.1 - 0.0025 17.7 40.5 0.017 15.1 3.3 6.4 6 0 0 6 6 6 3 Complement Clr-like EGF-like GBP_PSP PF02425.15 VDK82636.1 - 3 7.6 6.4 1.8 8.3 0.1 3.3 3 0 0 3 3 3 0 Paralytic/GBP/PSP peptide FXa_inhibition PF14670.6 VDK82636.1 - 3.4 8.0 56.8 1.8 8.9 8.3 6.1 4 1 1 5 5 4 0 Coagulation Factor Xa inhibitory site ICAM_N PF03921.14 VDK82636.1 - 8.3 6.2 8.4 0.31 10.8 0.0 3.1 4 0 0 4 4 3 0 Intercellular adhesion molecule (ICAM), N-terminal domain Ly-6_related PF06579.12 VDK82640.1 - 7.1e-30 103.8 0.3 8.3e-30 103.6 0.3 1.0 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein QVR PF17064.5 VDK82640.1 - 0.024 14.9 0.8 0.56 10.5 0.8 2.1 1 1 0 1 1 1 0 Sleepless protein LRR_8 PF13855.6 VDK82642.1 - 3.3e-26 90.8 39.4 4.6e-13 48.7 7.2 3.7 2 1 2 4 4 4 3 Leucine rich repeat ig PF00047.25 VDK82642.1 - 7.1e-07 29.3 0.2 1.4e-06 28.3 0.2 1.5 1 0 0 1 1 1 1 Immunoglobulin domain LRR_9 PF14580.6 VDK82642.1 - 1.7e-06 27.6 0.2 3.3e-05 23.5 0.1 2.3 2 0 0 2 2 2 1 Leucine-rich repeat I-set PF07679.16 VDK82642.1 - 5.6e-06 26.3 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain LRR_4 PF12799.7 VDK82642.1 - 6.2e-06 26.5 15.5 0.0006 20.1 3.1 3.8 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Ig_2 PF13895.6 VDK82642.1 - 3.1e-05 24.2 0.1 7.1e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain Ig_3 PF13927.6 VDK82642.1 - 4.9e-05 23.8 0.1 0.0001 22.8 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain C1-set PF07654.15 VDK82642.1 - 0.0026 18.1 0.4 0.0085 16.5 0.4 1.9 1 0 0 1 1 1 1 Immunoglobulin C1-set domain LRR_1 PF00560.33 VDK82642.1 - 0.0089 16.4 14.5 0.54 11.0 0.2 5.8 5 0 0 5 5 5 2 Leucine Rich Repeat V-set PF07686.17 VDK82642.1 - 0.085 13.0 0.1 0.5 10.5 0.1 2.2 1 1 0 1 1 1 0 Immunoglobulin V-set domain 7tm_2 PF00002.24 VDK82642.1 - 0.13 11.5 13.7 0.44 9.8 0.6 3.0 2 1 0 3 3 3 0 7 transmembrane receptor (Secretin family) zf-C4 PF00105.18 VDK82644.1 - 1.1e-27 96.2 14.4 1.1e-27 96.2 14.4 1.9 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK82644.1 - 2e-11 43.9 0.0 3.2e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Ets PF00178.22 VDK82646.1 - 1.6e-36 124.6 0.4 2.7e-36 123.9 0.4 1.4 1 0 0 1 1 1 1 Ets-domain HSF_DNA-bind PF00447.17 VDK82646.1 - 0.0026 18.3 0.2 0.0037 17.8 0.2 1.2 1 0 0 1 1 1 1 HSF-type DNA-binding Sec7 PF01369.20 VDK82664.1 - 7.5e-58 195.2 0.0 1.2e-57 194.5 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain IQ_SEC7_PH PF16453.5 VDK82664.1 - 1.4e-50 170.8 0.3 2.4e-50 170.1 0.3 1.4 1 0 0 1 1 1 1 PH domain Mog1 PF04603.12 VDK82664.1 - 0.013 15.8 0.0 0.032 14.6 0.0 1.6 1 0 0 1 1 1 0 Ran-interacting Mog1 protein DNA_pol3_a_NII PF11490.8 VDK82666.1 - 0.079 12.9 2.4 0.15 12.0 2.4 1.4 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Uso1_p115_head PF04869.14 VDK82667.1 - 7.2e-53 179.7 2.0 4.8e-52 177.0 0.3 2.5 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Arm_vescicular PF18770.1 VDK82667.1 - 6.6e-16 58.0 5.8 9.9e-16 57.4 2.4 2.7 2 0 0 2 2 2 1 Armadillo tether-repeat of vescicular transport factor Uso1_p115_C PF04871.13 VDK82667.1 - 1.5e-09 38.3 17.0 1.5e-09 38.3 17.0 3.0 1 1 1 2 2 2 1 Uso1 / p115 like vesicle tethering protein, C terminal region Atx10homo_assoc PF09759.9 VDK82667.1 - 0.00034 20.6 0.8 0.0068 16.4 0.4 3.2 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain ETRAMP PF09716.10 VDK82667.1 - 0.011 15.8 0.0 0.55 10.3 0.0 3.4 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF948 PF06103.11 VDK82667.1 - 0.73 10.1 3.4 4.2 7.7 0.3 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Phage_Mu_Gam PF07352.12 VDK82667.1 - 0.99 9.3 17.6 0.79 9.6 3.6 3.2 3 1 0 3 3 3 0 Bacteriophage Mu Gam like protein SepSecS PF05889.13 VDK82667.1 - 1.2 7.7 6.6 0.24 10.0 0.7 2.4 3 0 0 3 3 3 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Myosin_head PF00063.21 VDK82668.1 - 1.8e-82 277.6 0.0 1.8e-82 277.6 0.0 2.8 2 1 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 VDK82668.1 - 4.5e-07 28.1 122.6 5.7e-07 27.8 73.0 2.7 1 1 1 2 2 2 1 Myosin tail PDZ_6 PF17820.1 VDK82668.1 - 0.00034 20.4 0.0 0.0011 18.7 0.0 2.0 1 0 0 1 1 1 1 PDZ domain LEF-8 PF04941.12 VDK82668.1 - 0.00094 17.6 0.0 0.0017 16.7 0.0 1.3 1 0 0 1 1 1 1 Late expression factor 8 (LEF-8) AAA_16 PF13191.6 VDK82668.1 - 0.018 15.5 0.0 0.018 15.5 0.0 5.7 4 1 0 4 4 4 0 AAA ATPase domain PDZ PF00595.24 VDK82668.1 - 0.048 14.0 0.0 0.21 12.0 0.0 2.1 2 0 0 2 2 2 0 PDZ domain AAA_22 PF13401.6 VDK82668.1 - 0.17 12.1 0.0 0.17 12.1 0.0 4.9 5 1 0 5 5 5 0 AAA domain AAA_19 PF13245.6 VDK82668.1 - 0.34 11.2 2.5 0.5 10.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain zf-H2C2_2 PF13465.6 VDK82671.1 - 1.7e-26 91.4 54.7 1.1e-06 28.8 1.3 7.2 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2 PF00096.26 VDK82671.1 - 1.8e-26 91.0 61.4 3.1e-06 27.3 0.7 6.8 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK82671.1 - 6.8e-18 63.8 54.0 0.0017 19.0 0.4 6.7 7 0 0 7 7 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK82671.1 - 7.7e-08 32.4 40.0 0.046 14.0 0.3 7.0 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK82671.1 - 2.9e-06 27.1 48.0 0.0044 17.0 0.7 6.7 7 0 0 7 7 6 4 C2H2-type zinc finger zf-met PF12874.7 VDK82671.1 - 7.5e-05 23.0 37.7 0.32 11.4 0.4 7.1 6 1 2 8 8 8 3 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 VDK82671.1 - 0.0047 17.6 22.9 0.0087 16.8 4.2 3.2 1 1 2 3 3 3 1 zinc-ribbon family FYVE PF01363.21 VDK82671.1 - 0.0052 16.9 9.2 0.0052 16.9 9.2 4.1 1 1 2 3 3 3 1 FYVE zinc finger zf-H2C2_5 PF13909.6 VDK82671.1 - 0.012 15.3 3.1 0.012 15.3 3.1 5.2 5 2 0 5 5 4 0 C2H2-type zinc-finger domain zf_UBZ PF18439.1 VDK82671.1 - 0.023 14.3 19.3 0.46 10.1 0.1 5.8 5 2 0 5 5 5 0 Ubiquitin-Binding Zinc Finger zf-Sec23_Sec24 PF04810.15 VDK82671.1 - 0.039 14.0 21.8 1.8 8.7 0.7 5.7 5 1 0 5 5 5 0 Sec23/Sec24 zinc finger Zn_ribbon_SprT PF17283.2 VDK82671.1 - 0.067 13.1 18.6 0.15 11.9 4.4 3.7 2 2 0 2 2 2 0 SprT-like zinc ribbon domain XPA_N PF01286.18 VDK82671.1 - 0.1 12.7 22.5 2.7 8.1 0.4 6.3 6 0 0 6 6 6 0 XPA protein N-terminal CpXC PF14353.6 VDK82671.1 - 0.24 11.5 0.3 0.24 11.5 0.3 4.7 1 1 4 5 5 5 0 CpXC protein GAGA PF09237.11 VDK82671.1 - 0.28 11.0 13.3 8.4 6.3 1.1 5.1 2 2 3 5 5 5 0 GAGA factor Rep_fac-A_C PF08646.10 VDK82671.1 - 0.3 10.8 16.6 0.48 10.2 4.6 3.6 2 2 1 3 3 3 0 Replication factor-A C terminal domain BolA PF01722.18 VDK82671.1 - 0.33 11.3 7.5 3.3 8.1 0.1 3.6 3 1 0 3 3 3 0 BolA-like protein Zn-ribbon_8 PF09723.10 VDK82671.1 - 0.46 10.7 29.6 0.12 12.5 2.8 4.8 3 1 1 4 4 4 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 VDK82671.1 - 0.71 9.7 0.0 0.71 9.7 0.0 5.8 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2HC_2 PF13913.6 VDK82671.1 - 1 9.3 15.9 4.9 7.2 1.0 5.4 4 0 0 4 4 4 0 zinc-finger of a C2HC-type Zn_Tnp_IS1595 PF12760.7 VDK82671.1 - 1.8 8.6 26.5 0.46 10.5 3.5 3.6 4 0 0 4 4 3 0 Transposase zinc-ribbon domain zf-AN1 PF01428.16 VDK82671.1 - 3.3 8.0 37.5 2.5 8.4 0.9 6.2 5 1 1 6 6 6 0 AN1-like Zinc finger TF_Zn_Ribbon PF08271.12 VDK82671.1 - 5.7 6.6 12.9 27 4.4 0.2 3.9 3 1 0 3 3 3 0 TFIIB zinc-binding Zf_RING PF16744.5 VDK82671.1 - 9.5 6.4 27.7 1.9 8.7 1.5 5.3 1 1 4 5 5 5 0 KIAA1045 RING finger PilZ PF07238.14 VDK82672.1 - 0.16 12.3 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 PilZ domain Pkinase PF00069.25 VDK82681.1 - 6.7e-32 110.9 0.0 9.1e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK82681.1 - 7.1e-09 35.3 0.0 1.3e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 VDK82682.1 - 5.5e-06 26.7 0.6 0.042 14.2 0.1 4.0 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.22 VDK82682.1 - 9.6e-06 25.4 2.7 0.23 11.8 0.0 4.9 4 0 0 4 4 4 2 HEAT repeat HEAT PF02985.22 VDK82686.1 - 0.0025 17.9 0.1 0.19 12.1 0.1 2.6 2 0 0 2 2 2 2 HEAT repeat CENP-T_C PF15511.6 VDK82689.1 - 1.2e-08 35.0 0.1 1.5e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 VDK82689.1 - 1.7e-05 25.1 0.1 2.3e-05 24.7 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 VDK82689.1 - 4.3e-05 23.7 0.1 6.6e-05 23.1 0.1 1.4 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 VDK82689.1 - 4.4e-05 23.6 0.1 6e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 VDK82689.1 - 6.4e-05 23.3 0.2 7.4e-05 23.1 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 VDK82689.1 - 0.0049 16.8 0.1 0.0075 16.3 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 VDK82689.1 - 0.0074 16.4 0.0 0.0086 16.1 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone_H2A_C PF16211.5 VDK82690.1 - 1.1e-20 73.1 1.0 2.5e-20 71.9 1.0 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 VDK82690.1 - 3.4e-16 59.8 0.0 4.1e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 VDK82690.1 - 3.7e-07 30.3 0.0 5e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK82691.1 - 3.4e-24 85.7 0.7 4.4e-24 85.3 0.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 VDK82691.1 - 1.6e-06 28.3 0.1 2.8e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 VDK82691.1 - 0.0011 19.4 0.0 0.0023 18.4 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 VDK82691.1 - 0.0017 18.4 0.3 0.0021 18.1 0.3 1.1 1 0 0 1 1 1 1 YscO-like protein Radical_SAM PF04055.21 VDK82691.1 - 0.006 17.0 0.0 0.0081 16.6 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily DUF1931 PF09123.11 VDK82691.1 - 0.14 12.3 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1931) Lzipper-MIP1 PF14389.6 VDK82708.1 - 0.09 13.1 0.3 0.26 11.6 0.1 1.8 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Cep57_CLD_2 PF14197.6 VDK82710.1 - 0.0057 16.7 1.5 0.0057 16.7 1.5 14.0 9 4 5 14 14 14 1 Centrosome localisation domain of PPC89 GIT_CC PF16559.5 VDK82710.1 - 0.0058 16.5 2.3 0.0058 16.5 2.3 11.1 8 3 5 13 13 13 2 GIT coiled-coil Rho guanine nucleotide exchange factor Calx-beta PF03160.14 VDK82710.1 - 0.033 14.4 0.0 0.21 11.8 0.0 2.4 1 0 0 1 1 1 0 Calx-beta domain POTRA PF07244.15 VDK82710.1 - 0.11 13.1 0.3 0.11 13.1 0.3 3.6 4 0 0 4 4 4 0 Surface antigen variable number repeat Tetraspanin PF00335.20 VDK82712.1 - 3.5e-23 82.5 8.5 4.1e-23 82.3 8.5 1.1 1 0 0 1 1 1 1 Tetraspanin family FtsX PF02687.21 VDK82712.1 - 0.18 12.3 12.3 0.4 11.2 5.3 2.3 2 0 0 2 2 2 0 FtsX-like permease family Lipase_GDSL_2 PF13472.6 VDK82714.1 - 0.00014 22.3 0.0 0.00017 22.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 VDK82714.1 - 0.00068 19.7 0.0 0.0013 18.8 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase ubiquitin PF00240.23 VDK82731.1 - 1.7e-34 117.3 0.7 2.9e-34 116.6 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 VDK82731.1 - 5.5e-31 106.2 11.4 8.4e-31 105.6 11.4 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 VDK82731.1 - 1.2e-16 60.3 2.2 1.7e-16 59.8 0.6 1.8 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 VDK82731.1 - 1e-05 25.9 0.2 4.1e-05 23.9 0.2 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 VDK82731.1 - 0.0024 18.2 0.1 0.0046 17.3 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 VDK82731.1 - 0.004 17.0 0.0 0.0054 16.6 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 VDK82731.1 - 0.0043 17.1 0.1 0.0086 16.2 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 VDK82731.1 - 0.0096 15.9 1.1 3 8.0 0.2 2.2 2 0 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 VDK82731.1 - 0.016 15.8 0.1 0.022 15.3 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 VDK82731.1 - 0.048 13.5 0.0 0.067 13.0 0.0 1.2 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain Fer2_3 PF13085.6 VDK82731.1 - 0.28 11.2 2.4 0.53 10.3 0.1 2.1 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Pkinase PF00069.25 VDK82733.1 - 3.8e-28 98.6 0.1 4.9e-28 98.2 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK82733.1 - 1.1e-14 54.4 0.0 1.4e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK82733.1 - 0.00024 20.0 0.0 0.00036 19.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK82733.1 - 0.024 14.0 0.1 0.049 13.0 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TMEM131_like PF12371.8 VDK82735.1 - 1.1e-09 38.4 4.8 0.00017 21.8 0.1 5.1 4 1 1 5 5 5 2 Transmembrane protein 131-like ASH PF15780.5 VDK82735.1 - 3e-09 37.0 7.0 0.67 10.2 0.0 6.4 6 1 1 7 7 7 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF1573 PF07610.11 VDK82735.1 - 0.14 12.2 0.7 38 4.4 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1573) Metallophos PF00149.28 VDK82737.1 - 3.4e-32 112.6 0.0 4.8e-32 112.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK82737.1 - 8.7e-07 29.3 0.1 2.4e-06 27.9 0.1 1.8 1 1 1 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Pkinase_Tyr PF07714.17 VDK82738.1 - 1.8e-58 197.9 0.0 3.4e-58 197.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Recep_L_domain PF01030.24 VDK82738.1 - 6.4e-41 139.0 1.4 1.5e-25 89.5 0.2 3.3 2 1 0 2 2 2 2 Receptor L domain Pkinase PF00069.25 VDK82738.1 - 1.5e-32 113.0 0.0 2.5e-32 112.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Furin-like PF00757.20 VDK82738.1 - 7.8e-21 74.5 35.5 7.8e-21 74.5 35.5 1.7 2 0 0 2 2 2 1 Furin-like cysteine rich region fn3 PF00041.21 VDK82738.1 - 5e-16 58.8 0.5 0.0014 19.0 0.0 4.5 4 0 0 4 4 4 4 Fibronectin type III domain RGS-like PF09128.11 VDK82744.1 - 5.9e-45 153.3 2.3 7.5e-44 149.7 0.0 2.0 2 0 0 2 2 2 1 Regulator of G protein signalling-like domain RGS PF00615.19 VDK82744.1 - 5.4e-05 23.4 0.1 0.00011 22.4 0.1 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain L27_2 PF09045.10 VDK82744.1 - 0.0096 15.9 0.1 0.022 14.7 0.1 1.6 1 0 0 1 1 1 1 L27_2 DUF1870 PF08965.10 VDK82744.1 - 0.039 14.0 1.6 0.49 10.4 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) Lustrin_cystein PF14625.6 VDK82745.1 - 2.5e-05 24.6 38.6 3.6e-05 24.0 11.0 3.4 3 0 0 3 3 3 2 Lustrin, cysteine-rich repeated domain Mucin PF01456.17 VDK82745.1 - 0.0021 18.1 17.4 0.0036 17.3 17.4 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein FSA_C PF10479.9 VDK82745.1 - 2.8 6.0 10.0 3.8 5.5 10.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 VDK82745.1 - 5.4 5.1 15.0 7.9 4.5 15.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Hid1 PF12722.7 VDK82746.1 - 5.6e-259 861.6 7.4 3.5e-215 716.8 2.7 2.1 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 VDK82746.1 - 5e-220 732.2 1.6 5.6e-220 732.0 1.6 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein M-inducer_phosp PF06617.13 VDK82746.1 - 0.13 11.5 0.0 0.32 10.3 0.0 1.5 1 0 0 1 1 1 0 M-phase inducer phosphatase zf-C2H2 PF00096.26 VDK82747.1 - 1.8e-18 65.9 63.9 0.0031 17.9 5.8 8.2 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK82747.1 - 7.8e-18 64.0 54.7 4.1e-06 27.0 0.8 8.7 9 0 0 9 9 9 5 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK82747.1 - 1.6e-13 50.2 58.0 0.014 16.2 0.5 8.1 7 0 0 7 7 7 7 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK82747.1 - 7.2e-12 44.8 58.6 3.2e-06 26.8 5.6 8.1 8 1 0 8 8 8 5 C2H2-type zinc-finger domain Actin_micro PF17003.5 VDK82747.1 - 0.0013 18.0 2.4 0.0013 18.0 2.4 3.5 1 1 0 2 2 2 1 Putative actin-like family zf_C2H2_ZHX PF18387.1 VDK82747.1 - 0.068 12.8 0.2 0.068 12.8 0.2 6.0 5 1 1 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF1593 PF07632.11 VDK82747.1 - 0.073 12.5 0.4 0.12 11.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) zf-met PF12874.7 VDK82747.1 - 0.16 12.4 31.1 1.1 9.8 1.7 6.7 5 1 1 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 VDK82747.1 - 5.5 6.8 13.9 1.3 8.9 0.1 4.5 4 0 0 4 4 4 0 zinc-finger C2H2-type SpdB PF05122.13 VDK82747.1 - 7.4 6.8 12.1 2.6 8.3 2.1 3.3 3 0 0 3 3 3 0 Mobile element transfer protein zf-C2H2 PF00096.26 VDK82748.1 - 5.3e-08 32.9 17.1 0.0015 18.9 5.8 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK82748.1 - 5.2e-07 29.8 13.7 3.9e-06 27.0 1.0 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-H2C2_5 PF13909.6 VDK82748.1 - 1.6e-06 27.7 5.6 1.6e-06 27.7 5.6 3.4 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 VDK82748.1 - 0.00012 22.6 17.0 0.033 15.0 4.2 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger Actin_micro PF17003.5 VDK82748.1 - 0.00069 18.9 3.9 0.00095 18.4 3.9 1.3 1 0 0 1 1 1 1 Putative actin-like family zf_C2H2_ZHX PF18387.1 VDK82748.1 - 0.012 15.2 0.2 0.031 13.9 0.2 1.7 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF1593 PF07632.11 VDK82748.1 - 0.028 13.9 0.4 0.036 13.5 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) zf-C2HE PF16278.5 VDK82748.1 - 0.2 12.1 6.8 0.55 10.7 6.5 1.9 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 VDK82748.1 - 0.85 9.6 8.4 0.094 12.6 3.6 1.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type FYVE PF01363.21 VDK82748.1 - 1.6 8.9 6.5 3.3 7.9 6.4 1.5 1 1 0 1 1 1 0 FYVE zinc finger Hid1 PF12722.7 VDK82749.1 - 5.9e-259 861.6 7.3 3.7e-215 716.7 2.7 2.1 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 VDK82749.1 - 5.3e-220 732.1 1.6 5.9e-220 731.9 1.6 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein M-inducer_phosp PF06617.13 VDK82749.1 - 0.13 11.5 0.0 0.32 10.2 0.0 1.5 1 0 0 1 1 1 0 M-phase inducer phosphatase Annexin PF00191.20 VDK82755.1 - 4e-96 315.1 10.6 1.7e-25 88.9 0.3 4.1 4 0 0 4 4 4 4 Annexin DEAD PF00270.29 VDK82757.1 - 3.6e-44 150.6 0.0 8.7e-44 149.4 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK82757.1 - 3e-28 98.4 0.9 8.6e-28 96.9 0.9 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK82757.1 - 3.6e-06 27.1 0.0 1.2e-05 25.4 0.0 1.9 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 VDK82757.1 - 0.019 14.2 0.3 0.032 13.5 0.3 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase IpaB_EvcA PF03278.13 VDK82758.1 - 0.16 11.7 0.3 0.47 10.2 0.1 1.8 2 0 0 2 2 2 0 IpaB/EvcA family Hydrolase_2 PF07486.12 VDK82758.1 - 0.5 11.3 1.7 0.72 10.7 0.1 2.1 3 0 0 3 3 3 0 Cell Wall Hydrolase Dynamin_M PF01031.20 VDK82759.1 - 0.051 12.8 1.0 0.12 11.5 1.0 1.6 1 0 0 1 1 1 0 Dynamin central region I-set PF07679.16 VDK82765.1 - 1.8e-171 556.7 2.9 1.2e-18 66.9 0.0 12.3 12 0 0 12 12 12 11 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK82765.1 - 2.5e-125 409.3 8.3 1.3e-14 54.6 0.0 10.6 10 0 0 10 10 10 10 Immunoglobulin domain ig PF00047.25 VDK82765.1 - 2e-68 226.6 9.7 9.7e-08 32.1 0.4 10.5 10 0 0 10 10 10 10 Immunoglobulin domain Ig_2 PF13895.6 VDK82765.1 - 9.2e-68 224.6 12.2 1.1e-08 35.2 0.0 11.3 11 0 0 11 11 11 10 Immunoglobulin domain V-set PF07686.17 VDK82765.1 - 1.3e-38 131.5 28.1 4.7e-05 23.5 0.6 16.3 10 7 0 10 10 10 8 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK82765.1 - 2.3e-13 50.0 11.6 0.014 15.5 0.0 10.5 11 1 2 13 13 12 3 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 VDK82765.1 - 2.8e-11 43.5 19.3 0.0057 16.9 0.2 10.8 10 3 0 10 10 10 3 T-cell surface glycoprotein CD3 delta chain C1-set PF07654.15 VDK82765.1 - 4.2e-10 39.9 3.0 5.7 7.4 0.0 8.0 7 0 0 7 7 7 2 Immunoglobulin C1-set domain Ig_6 PF18452.1 VDK82765.1 - 1.7e-09 37.1 5.3 0.0037 16.8 0.0 7.6 9 0 0 9 9 9 1 Immunoglobulin domain Ig_5 PF16681.5 VDK82765.1 - 7.7e-09 35.9 15.7 0.027 14.9 0.1 9.8 11 0 0 11 11 9 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_C17orf99 PF17736.1 VDK82765.1 - 2.6e-08 33.8 3.0 0.53 10.3 0.0 7.5 9 0 0 9 9 8 2 C17orf99 Ig domain Receptor_2B4 PF11465.8 VDK82765.1 - 6e-08 32.9 1.4 5 7.4 0.0 7.5 9 0 0 9 9 8 1 Natural killer cell receptor 2B4 Izumo-Ig PF16706.5 VDK82765.1 - 7.9e-08 32.3 10.3 9.4 6.4 0.0 9.7 11 0 0 11 11 11 1 Izumo-like Immunoglobulin domain Herpes_gE PF02480.16 VDK82765.1 - 2e-05 23.5 7.8 2.2 6.9 0.1 6.8 7 1 1 8 8 8 2 Alphaherpesvirus glycoprotein E V-set_CD47 PF08204.11 VDK82765.1 - 0.00011 22.2 1.9 9.4 6.2 0.0 6.8 7 0 0 7 7 7 1 CD47 immunoglobulin-like domain fn3 PF00041.21 VDK82765.1 - 0.00011 22.4 0.0 0.0012 19.2 0.0 2.9 2 0 0 2 2 1 1 Fibronectin type III domain UL141 PF16758.5 VDK82765.1 - 0.001 18.8 4.1 0.057 13.1 0.0 4.8 6 0 0 6 6 6 1 Herpes-like virus membrane glycoprotein UL141 PDZ_2 PF13180.6 VDK82766.1 - 1.5e-13 50.9 0.7 2.1e-05 24.8 0.2 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK82766.1 - 3.9e-12 45.8 1.3 1.2e-06 28.3 0.1 2.6 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 VDK82766.1 - 4.1e-11 43.1 0.4 0.00015 22.1 0.1 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 VDK82766.1 - 0.00038 20.4 0.0 0.13 12.2 0.0 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain PDZ_4 PF17816.1 VDK82766.1 - 0.0006 20.2 0.1 0.16 12.4 0.0 2.4 2 0 0 2 2 2 2 PDZ domain TUDOR PF00567.24 VDK82768.1 - 1.9e-05 24.7 0.7 0.011 15.7 0.0 3.3 3 1 0 3 3 3 2 Tudor domain WD40 PF00400.32 VDK82770.1 - 4.7e-19 68.4 4.6 5.2e-05 23.9 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK82770.1 - 0.0022 18.3 0.0 1.6 9.0 0.0 4.0 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Cystatin PF00031.21 VDK82772.1 - 8.1e-09 35.6 0.0 1.3e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 VDK82772.1 - 2.6e-06 27.7 0.1 3.9e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 VDK82773.1 - 4.6e-08 33.2 0.6 5.7e-08 32.9 0.6 1.1 1 0 0 1 1 1 1 Cystatin domain An_peroxidase PF03098.15 VDK82777.1 - 6e-136 454.1 0.0 7.9e-136 453.7 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase NAD_binding_6 PF08030.12 VDK82777.1 - 1.1e-27 97.1 0.0 2.2e-27 96.1 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 VDK82777.1 - 1e-16 61.0 0.1 5.5e-16 58.6 0.0 2.2 2 1 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 VDK82777.1 - 2.9e-15 56.5 8.2 2.9e-15 56.5 8.2 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component EF-hand_8 PF13833.6 VDK82777.1 - 0.0017 18.2 0.1 0.005 16.7 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK82777.1 - 0.0065 16.3 0.1 0.23 11.5 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 VDK82777.1 - 0.026 15.0 3.2 0.12 12.8 0.1 3.5 3 1 1 4 4 4 0 EF-hand domain pair EF-hand_1 PF00036.32 VDK82777.1 - 0.03 13.9 0.0 0.15 11.7 0.0 2.3 1 0 0 1 1 1 0 EF hand HSP20 PF00011.21 VDK82778.1 - 3.7e-12 46.3 0.1 4.5e-12 46.0 0.1 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK82778.1 - 0.00045 19.7 0.0 0.0008 18.9 0.0 1.4 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Thioredoxin PF00085.20 VDK82779.1 - 2.1e-95 313.5 1.0 6.4e-31 106.4 0.0 3.4 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 VDK82779.1 - 7e-25 88.0 7.9 5.2e-14 52.6 0.5 4.3 2 1 2 4 4 4 4 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK82779.1 - 6.9e-17 61.6 2.3 8.5e-05 22.8 0.0 6.8 4 3 2 6 6 6 3 Thioredoxin-like Thioredoxin_2 PF13098.6 VDK82779.1 - 1.3e-14 54.5 7.0 0.00038 20.9 0.1 6.2 4 3 0 4 4 4 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 VDK82779.1 - 2.3e-12 46.9 0.0 0.0016 18.6 0.0 3.7 3 0 0 3 3 3 3 Thioredoxin-like OST3_OST6 PF04756.13 VDK82779.1 - 2.1e-11 43.7 0.0 0.0016 17.9 0.0 3.6 2 1 1 3 3 3 3 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 VDK82779.1 - 2.2e-11 43.7 2.5 0.0037 17.2 0.0 4.7 4 1 0 4 4 4 3 AhpC/TSA family Calsequestrin PF01216.17 VDK82779.1 - 8.9e-08 31.6 3.2 5.2e-07 29.0 1.1 2.8 2 1 1 3 3 3 1 Calsequestrin Thioredoxin_4 PF13462.6 VDK82779.1 - 2.1e-06 28.0 3.5 0.55 10.4 0.1 5.1 3 2 2 5 5 5 1 Thioredoxin TraF PF13728.6 VDK82779.1 - 2.3e-06 27.6 0.0 0.32 10.8 0.0 3.6 3 0 0 3 3 3 2 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 VDK82779.1 - 4.3e-06 26.7 0.0 0.64 10.1 0.0 3.6 3 0 0 3 3 3 2 Thioredoxin domain Redoxin PF08534.10 VDK82779.1 - 5e-05 23.1 5.6 1.9 8.2 0.0 4.7 5 0 0 5 5 5 2 Redoxin Glutaredoxin PF00462.24 VDK82779.1 - 0.0024 18.1 6.2 7.6 6.8 0.2 4.6 4 1 0 4 4 4 2 Glutaredoxin Thioredoxin_5 PF13743.6 VDK82779.1 - 0.014 15.1 2.5 58 3.3 0.1 5.0 4 2 2 6 6 6 0 Thioredoxin Chordopox_A35R PF05989.12 VDK82779.1 - 0.021 14.7 0.1 0.042 13.7 0.1 1.4 1 0 0 1 1 1 0 Chordopoxvirus A35R protein HyaE PF07449.11 VDK82779.1 - 0.023 14.7 0.0 5.6 7.0 0.0 3.1 3 0 0 3 3 3 0 Hydrogenase-1 expression protein HyaE UCH_1 PF13423.6 VDK82779.1 - 0.063 12.9 0.1 9.4 5.7 0.0 2.8 2 1 1 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase DUF3228 PF11539.8 VDK82779.1 - 0.066 12.7 1.9 24 4.4 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3228) Sigma_reg_C PF13791.6 VDK82779.1 - 0.11 12.7 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Sigma factor regulator C-terminal IBR PF01485.21 VDK82780.1 - 0.0002 21.5 5.0 0.0002 21.5 5.0 3.4 2 1 1 3 3 3 1 IBR domain, a half RING-finger domain Trypsin PF00089.26 VDK82781.1 - 2.7e-17 63.3 0.0 4e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 VDK82781.1 - 1.1e-05 26.4 0.0 1.8e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain PUF PF00806.19 VDK82783.1 - 4.9e-39 129.8 2.0 8.8e-05 22.0 0.0 7.8 8 0 0 8 8 8 7 Pumilio-family RNA binding repeat Fez1 PF06818.15 VDK82784.1 - 0.0022 18.5 17.3 0.0022 18.5 17.3 4.3 1 1 2 3 3 3 1 Fez1 CRISPR_Cse1 PF09481.10 VDK82784.1 - 2.8 6.9 7.2 0.15 11.1 1.8 1.7 2 0 0 2 2 2 0 CRISPR-associated protein Cse1 (CRISPR_cse1) E1_dh PF00676.20 VDK82791.1 - 3.8e-22 78.6 0.1 8e-22 77.5 0.1 1.5 1 1 1 2 2 2 1 Dehydrogenase E1 component Nucleoplasmin PF03066.15 VDK82791.1 - 0.14 12.6 0.0 0.15 12.6 0.0 1.2 1 0 0 1 1 1 0 Nucleoplasmin/nucleophosmin domain E1_dh PF00676.20 VDK82792.1 - 3.3e-78 262.7 0.1 3.8e-78 262.5 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component E1_dh PF00676.20 VDK82793.1 - 1.6e-109 365.4 0.0 2e-109 365.2 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 VDK82793.1 - 0.024 14.4 1.0 0.046 13.5 1.0 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 VDK82793.1 - 0.086 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase Ufd2P_core PF10408.9 VDK82794.1 - 1.1e-155 519.8 14.7 1.4e-155 519.4 14.7 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 VDK82794.1 - 8.8e-28 96.3 2.9 4.8e-27 93.9 1.6 2.6 2 0 0 2 2 2 1 U-box domain DUF2368 PF10166.9 VDK82795.1 - 7.7e-11 41.7 0.1 9.3e-11 41.5 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) DUF2368 PF10166.9 VDK82796.1 - 1.8e-10 40.6 1.0 3.5e-10 39.6 0.1 1.7 1 1 1 2 2 2 1 Uncharacterised conserved protein (DUF2368) Pkinase PF00069.25 VDK82797.1 - 0.071 12.5 0.0 0.094 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain FANCI_HD2 PF14680.6 VDK82801.1 - 3e-30 105.3 4.6 1.2e-29 103.3 4.6 2.2 1 0 0 1 1 1 1 FANCI helical domain 2 FANCI_HD1 PF14679.6 VDK82801.1 - 3.7e-05 23.6 4.3 5.1e-05 23.2 0.3 3.4 3 0 0 3 3 3 1 FANCI helical domain 1 T3SS_needle_E PF08988.10 VDK82803.1 - 0.027 14.6 0.1 0.63 10.2 0.0 2.4 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle FlaC_arch PF05377.11 VDK82803.1 - 0.19 12.2 1.9 3.6 8.0 0.0 2.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) EGF PF00008.27 VDK82805.1 - 1.2e-08 35.1 76.9 0.00042 20.6 4.5 9.6 8 3 0 8 8 8 6 EGF-like domain EGF_2 PF07974.13 VDK82805.1 - 0.00045 20.5 6.7 0.00045 20.5 6.7 8.2 7 2 0 7 7 7 3 EGF-like domain FAM176 PF14851.6 VDK82805.1 - 0.014 15.1 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 FAM176 family Methyltransf_10 PF05971.12 VDK82807.1 - 5.5e-77 259.0 0.0 7e-77 258.7 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 VDK82807.1 - 1.9e-08 34.0 0.0 3.8e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 VDK82807.1 - 4.1e-07 29.7 0.0 5.8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_3 PF01596.17 VDK82807.1 - 0.0026 17.0 0.0 0.0053 16.0 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_25 PF13649.6 VDK82807.1 - 0.015 15.9 0.0 0.039 14.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_18 PF12847.7 VDK82807.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 VDK82807.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 VDK82807.1 - 0.18 11.6 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain LIM PF00412.22 VDK82809.1 - 4.6e-61 202.9 50.7 2.9e-16 59.4 5.1 4.3 4 0 0 4 4 4 4 LIM domain zf_C2H2_13 PF18508.1 VDK82809.1 - 0.7 9.5 0.0 0.7 9.5 0.0 6.2 5 2 2 7 7 7 0 Zinc finger domain DUF3725 PF12523.8 VDK82809.1 - 2 8.8 18.9 2 8.8 0.4 5.0 5 0 0 5 5 5 0 Protein of unknown function (DUF3725) Serpin PF00079.20 VDK82810.1 - 7.4e-64 216.4 0.7 8.7e-64 216.1 0.7 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Urb2 PF10441.9 VDK82810.1 - 0.094 12.6 0.5 0.17 11.8 0.5 1.3 1 0 0 1 1 1 0 Urb2/Npa2 family GST_N_3 PF13417.6 VDK82811.1 - 2.8e-14 53.3 0.0 4.3e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 VDK82811.1 - 6.6e-11 42.4 0.1 1e-10 41.8 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 VDK82811.1 - 1.1e-08 35.3 0.0 1.8e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 VDK82811.1 - 4.7e-07 29.9 0.1 6.5e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 VDK82811.1 - 0.00029 21.2 0.0 0.00048 20.5 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) OFCC1 PF15680.5 VDK82815.1 - 1 9.9 7.7 4.9 7.8 0.5 2.8 3 0 0 3 3 3 0 Orofacial cleft 1 candidate gene 1 protein 2-Hacid_dh_C PF02826.19 VDK82818.1 - 5.9e-51 172.3 0.0 9.1e-51 171.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 VDK82818.1 - 3.1e-27 94.8 0.0 6.9e-27 93.7 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 VDK82818.1 - 4e-06 27.1 1.0 2e-05 24.8 0.0 2.6 4 0 0 4 4 4 1 NAD binding domain of 6-phosphogluconate dehydrogenase THAP PF05485.12 VDK82820.1 - 3.4e-05 24.7 1.0 9.3e-05 23.3 1.0 1.7 1 1 0 1 1 1 1 THAP domain Ras PF00071.22 VDK82821.1 - 2.7e-23 82.4 1.5 3.1e-23 82.2 1.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK82821.1 - 2.2e-10 40.8 0.1 3.2e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 VDK82821.1 - 4e-06 26.9 0.0 4.9e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 VDK82821.1 - 0.0015 19.1 0.1 0.0035 17.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 VDK82821.1 - 0.006 16.3 0.1 0.0081 15.9 0.1 1.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 VDK82821.1 - 0.018 14.9 0.3 0.13 12.2 0.0 2.1 2 1 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 VDK82821.1 - 0.13 12.8 0.1 0.16 12.5 0.1 1.3 1 1 0 1 1 1 0 ABC transporter LIM PF00412.22 VDK82822.1 - 2.5e-21 75.7 26.1 9.2e-11 41.8 9.1 2.3 2 0 0 2 2 2 2 LIM domain Aa_trans PF01490.18 VDK82825.1 - 1.3e-23 83.4 11.3 1.5e-23 83.2 11.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2070 PF09843.9 VDK82825.1 - 0.095 11.0 5.3 0.1 10.9 5.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DNA_pol_A_exo1 PF01612.20 VDK82826.1 - 1.1e-20 74.0 0.0 3e-20 72.7 0.0 1.7 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 VDK82826.1 - 2.7e-13 50.4 0.1 2.7e-12 47.2 0.0 2.6 3 0 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.23 VDK82826.1 - 4.8e-12 45.7 0.2 2.6e-11 43.4 0.0 2.4 2 0 0 2 2 2 1 HRDC domain Glyco_transf_22 PF03901.17 VDK82828.1 - 1.1e-89 301.6 31.8 1.3e-89 301.3 31.8 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family MRP-S22 PF10245.9 VDK82829.1 - 1.5e-71 241.0 0.0 2.5e-71 240.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S22 GYF PF02213.16 VDK82830.1 - 6.2e-16 57.8 0.1 1.2e-15 56.9 0.1 1.5 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 VDK82830.1 - 0.021 14.6 0.6 0.065 13.0 0.1 2.2 2 0 0 2 2 2 0 GYF domain 2 DUF5401 PF17380.2 VDK82830.1 - 6.5 4.7 50.4 10 4.1 50.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) EF-hand_7 PF13499.6 VDK82832.1 - 6.1e-10 39.4 0.1 1.6e-07 31.6 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 VDK82832.1 - 3.5e-06 26.8 0.0 0.1 12.4 0.0 3.3 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 VDK82832.1 - 2.1e-05 24.1 1.7 0.015 15.2 0.0 3.9 5 0 0 5 5 5 1 EF-hand domain EF-hand_1 PF00036.32 VDK82832.1 - 0.00062 19.1 3.3 0.7 9.6 0.1 3.3 4 0 0 4 4 4 2 EF hand RST PF12174.8 VDK82832.1 - 0.045 13.7 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain LPD11 PF18824.1 VDK82832.1 - 0.1 12.7 0.4 3.8 7.7 0.1 2.6 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 NUDE_C PF04880.13 VDK82838.1 - 3.3e-12 47.2 4.5 3.3e-12 47.2 4.5 3.2 1 1 2 3 3 3 1 NUDE protein, C-terminal conserved region APG6_N PF17675.1 VDK82838.1 - 0.056 14.0 35.2 2.9 8.4 32.7 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region WD40_alt PF14077.6 VDK82838.1 - 0.095 12.6 0.7 0.095 12.6 0.7 2.5 2 0 0 2 2 2 0 Alternative WD40 repeat motif Serine_rich PF08824.10 VDK82838.1 - 0.11 12.4 9.8 0.44 10.5 9.5 2.2 1 1 0 1 1 1 0 Serine rich protein interaction domain SpecificRecomb PF10136.9 VDK82838.1 - 2.1 6.5 6.4 2.9 6.1 6.4 1.2 1 0 0 1 1 1 0 Site-specific recombinase DUF4410 PF14366.6 VDK82838.1 - 4.4 7.2 5.1 1.4 8.8 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4410) V_ATPase_I PF01496.19 VDK82838.1 - 6.5 4.5 13.0 9.4 4.0 13.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ras PF00071.22 VDK82839.1 - 1.2e-54 184.3 0.0 1.4e-54 184.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK82839.1 - 1.2e-22 80.4 0.0 1.7e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK82839.1 - 8.5e-09 35.1 0.0 1e-08 34.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family C2 PF00168.30 VDK82840.1 - 5.8e-19 68.3 0.0 1.2e-18 67.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 VDK82840.1 - 0.01 16.5 0.0 0.7 10.6 0.0 2.6 2 0 0 2 2 2 0 Putative heavy-metal-binding FH2 PF02181.23 VDK82843.1 - 5.1e-91 305.6 1.3 5.1e-91 305.6 1.3 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 VDK82843.1 - 2.4e-29 102.2 13.5 3.6e-15 56.0 0.3 2.9 3 0 0 3 3 3 2 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 VDK82843.1 - 1.7e-24 86.5 12.9 4e-24 85.3 12.9 1.7 1 0 0 1 1 1 1 Diaphanous FH3 Domain zf-C4H2 PF10146.9 VDK82843.1 - 0.016 15.5 4.4 0.058 13.7 4.4 2.0 1 0 0 1 1 1 0 Zinc finger-containing protein Spc7 PF08317.11 VDK82843.1 - 0.027 13.4 15.2 0.053 12.4 15.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 VDK82843.1 - 0.092 12.8 3.2 0.32 11.0 3.2 1.9 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0242 PF06785.11 VDK82843.1 - 0.97 9.5 13.2 2.3 8.3 13.2 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 VDK82843.1 - 2.1 6.9 11.2 2.6 6.6 9.4 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A JIP_LZII PF16471.5 VDK82843.1 - 2.6 8.3 15.5 4.8 7.4 5.5 2.9 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II CHD5 PF04420.14 VDK82843.1 - 2.9 7.7 6.8 2 8.3 4.5 1.9 1 1 0 1 1 1 0 CHD5-like protein CLZ PF16526.5 VDK82843.1 - 4.2 7.8 17.4 2.4 8.6 5.0 3.2 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Totivirus_coat PF05518.11 VDK82843.1 - 5.7 4.9 7.7 8.4 4.3 7.7 1.1 1 0 0 1 1 1 0 Totivirus coat protein DUF4407 PF14362.6 VDK82843.1 - 6.2 6.1 7.9 14 4.9 7.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YlqD PF11068.8 VDK82843.1 - 7.6 6.9 11.7 9.7 6.6 10.2 2.0 1 1 0 1 1 1 0 YlqD protein DUF1664 PF07889.12 VDK82843.1 - 8.4 6.4 8.5 26 4.8 8.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Y_phosphatase PF00102.27 VDK82845.1 - 3.5e-57 193.7 0.3 3.5e-57 193.7 0.3 2.6 2 1 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK82845.1 - 9e-05 22.3 0.0 0.00029 20.7 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK82845.1 - 0.0071 16.3 1.5 0.016 15.1 0.0 2.1 2 0 0 2 2 2 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 VDK82845.1 - 0.15 12.2 0.0 0.15 12.2 0.0 2.6 2 1 1 3 3 3 0 Inositol hexakisphosphate Dicty_REP PF05086.12 VDK82845.1 - 5.9 4.7 9.9 8.6 4.2 9.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SIP1 PF04938.12 VDK82847.1 - 7.1e-37 127.2 0.1 9.5e-31 107.2 0.0 3.0 1 1 2 3 3 3 3 Survival motor neuron (SMN) interacting protein 1 (SIP1) PHD PF00628.29 VDK82849.1 - 2.1e-24 85.2 79.6 3.9e-09 36.3 5.8 8.4 7 1 2 9 9 9 5 PHD-finger FYRN PF05964.14 VDK82849.1 - 2.3e-18 65.7 0.0 6.5e-18 64.3 0.0 1.8 1 0 0 1 1 1 1 F/Y-rich N-terminus SET PF00856.28 VDK82849.1 - 1.4e-17 64.6 6.5 1.6e-17 64.4 0.1 3.7 4 1 0 4 4 4 1 SET domain FYRC PF05965.14 VDK82849.1 - 6.6e-16 58.2 0.0 1.9e-15 56.8 0.0 1.9 1 0 0 1 1 1 1 F/Y rich C-terminus zf-HC5HC2H PF13771.6 VDK82849.1 - 1.2e-09 38.3 6.5 1.2e-09 38.3 6.5 7.0 5 1 2 7 7 6 2 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 VDK82849.1 - 2.1e-09 37.5 7.6 2.1e-09 37.5 7.6 6.5 4 2 2 6 6 4 2 PHD-zinc-finger like domain HMG_box_2 PF09011.10 VDK82849.1 - 0.072 13.7 7.5 0.013 16.1 2.7 2.3 2 0 0 2 2 1 0 HMG-box domain DUF3450 PF11932.8 VDK82849.1 - 0.094 12.0 3.0 0.22 10.8 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HMG_box PF00505.19 VDK82849.1 - 0.13 12.7 9.3 0.023 15.1 2.2 3.1 3 0 0 3 3 3 0 HMG (high mobility group) box zf-PHD-like PF15446.6 VDK82849.1 - 0.53 9.9 31.1 0.0058 16.3 4.4 4.4 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain AAA_9 PF12781.7 VDK82849.1 - 1.3 8.1 4.7 0.21 10.7 0.2 1.8 2 0 0 2 2 2 0 ATP-binding dynein motor region HscB_4_cys PF18256.1 VDK82849.1 - 8.9 6.2 17.2 3.2 7.6 2.9 5.9 5 0 0 5 5 5 0 Co-chaperone HscB tetracysteine metal binding motif AAA PF00004.29 VDK82850.1 - 8.8e-44 149.1 0.4 3.1e-43 147.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK82850.1 - 3.7e-12 45.8 0.1 8.9e-12 44.6 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 VDK82850.1 - 1.7e-07 31.5 1.8 5.1e-07 30.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 VDK82850.1 - 1.2e-06 28.5 0.0 4.8e-06 26.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_ID_OB PF16450.5 VDK82850.1 - 1.5e-06 28.1 0.2 3.8e-06 26.8 0.2 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 VDK82850.1 - 3.3e-06 27.6 0.1 7.9e-05 23.1 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 VDK82850.1 - 6.3e-05 22.8 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK82850.1 - 0.00023 21.4 3.9 0.015 15.6 0.1 3.0 2 2 1 3 3 3 1 AAA domain APG6_N PF17675.1 VDK82850.1 - 0.00042 20.9 0.6 0.0009 19.8 0.6 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region IstB_IS21 PF01695.17 VDK82850.1 - 0.0011 18.7 0.3 0.0063 16.3 0.0 2.1 2 1 1 3 3 3 1 IstB-like ATP binding protein AAA_33 PF13671.6 VDK82850.1 - 0.0014 18.8 0.3 0.0039 17.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain DUF2072 PF09845.9 VDK82850.1 - 0.0015 18.8 1.1 0.0029 17.8 1.1 1.5 1 0 0 1 1 1 1 Zn-ribbon containing protein AAA_11 PF13086.6 VDK82850.1 - 0.0016 18.3 1.4 0.44 10.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 VDK82850.1 - 0.002 17.4 0.0 0.0059 15.8 0.0 1.8 1 0 0 1 1 1 1 TIP49 P-loop domain Filament PF00038.21 VDK82850.1 - 0.003 17.2 5.9 0.0053 16.4 5.9 1.3 1 0 0 1 1 1 1 Intermediate filament protein AAA_18 PF13238.6 VDK82850.1 - 0.0039 17.7 0.1 0.017 15.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain MscS_porin PF12795.7 VDK82850.1 - 0.0064 16.1 4.7 0.011 15.3 4.7 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Mg_chelatase PF01078.21 VDK82850.1 - 0.0073 15.7 0.0 0.02 14.3 0.0 1.7 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 VDK82850.1 - 0.0082 15.5 0.5 0.027 13.8 0.0 2.0 2 0 0 2 2 2 1 KaiC AAA_3 PF07726.11 VDK82850.1 - 0.0098 15.8 0.0 0.029 14.2 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DUF1090 PF06476.12 VDK82850.1 - 0.011 15.9 6.9 0.14 12.3 4.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) Prominin PF05478.11 VDK82850.1 - 0.012 13.6 0.3 0.018 13.1 0.3 1.2 1 0 0 1 1 1 0 Prominin PhoH PF02562.16 VDK82850.1 - 0.013 15.0 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_28 PF13521.6 VDK82850.1 - 0.022 15.0 0.9 0.038 14.2 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_24 PF13479.6 VDK82850.1 - 0.026 14.3 0.0 0.075 12.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 VDK82850.1 - 0.027 14.2 0.1 0.13 11.9 0.0 2.2 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 VDK82850.1 - 0.037 13.5 0.0 0.077 12.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 VDK82850.1 - 0.043 14.2 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DUF815 PF05673.13 VDK82850.1 - 0.046 12.9 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TsaE PF02367.17 VDK82850.1 - 0.047 13.7 0.0 0.097 12.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 VDK82850.1 - 0.051 13.6 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 VDK82850.1 - 0.06 12.9 0.0 0.19 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 VDK82850.1 - 0.076 11.9 5.0 0.14 11.0 5.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein V_ATPase_I PF01496.19 VDK82850.1 - 0.082 10.8 1.7 0.12 10.3 1.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GAS PF13851.6 VDK82850.1 - 0.095 12.0 11.3 0.44 9.9 7.7 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding AAA_19 PF13245.6 VDK82850.1 - 0.11 12.9 0.1 0.36 11.2 0.0 1.9 2 0 0 2 2 1 0 AAA domain ABC_tran PF00005.27 VDK82850.1 - 0.11 13.0 0.4 1.3 9.5 0.0 2.6 2 1 0 2 2 2 0 ABC transporter AAA_17 PF13207.6 VDK82850.1 - 0.17 12.3 1.6 0.72 10.3 0.0 2.7 3 0 0 3 3 2 0 AAA domain SlyX PF04102.12 VDK82850.1 - 0.21 12.2 2.5 0.67 10.6 2.5 1.9 1 0 0 1 1 1 0 SlyX RILP PF11461.8 VDK82850.1 - 0.24 11.6 4.7 0.3 11.3 3.6 1.7 1 1 0 1 1 1 0 Rab interacting lysosomal protein HAUS-augmin3 PF14932.6 VDK82850.1 - 0.29 10.7 5.3 0.47 10.0 5.3 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 NPV_P10 PF05531.12 VDK82850.1 - 0.75 10.3 3.2 4.4 7.9 1.0 3.0 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 VDK82850.1 - 1.4 9.0 5.1 0.91 9.6 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 VDK82850.1 - 1.4 8.9 6.2 3.8 7.5 3.1 2.7 3 0 0 3 3 2 0 Laminin Domain II FlaC_arch PF05377.11 VDK82850.1 - 3 8.3 6.4 3.6 8.0 3.3 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) B9-C2 PF07162.11 VDK82862.1 - 6.9e-27 94.7 0.0 7.8e-27 94.5 0.0 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Thioredoxin_6 PF13848.6 VDK82864.1 - 4.4e-36 124.5 2.8 4.6e-34 118.0 0.2 2.5 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 VDK82864.1 - 4.3e-16 58.8 0.2 1.2e-15 57.3 0.2 1.8 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 VDK82864.1 - 0.00015 22.2 0.6 0.00094 19.6 0.1 2.4 2 1 0 3 3 3 1 Thioredoxin-like domain Calsequestrin PF01216.17 VDK82864.1 - 0.0013 17.9 0.5 0.0022 17.1 0.1 1.6 2 0 0 2 2 2 1 Calsequestrin Cation_efflux PF01545.21 VDK82865.1 - 4e-25 88.7 14.7 5.2e-25 88.4 14.7 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 VDK82865.1 - 2e-07 31.1 3.0 4.3e-07 30.0 3.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter NEMP PF10225.9 VDK82865.1 - 0.0027 17.4 1.6 0.0027 17.4 1.6 1.7 2 0 0 2 2 2 1 NEMP family Voltage_CLC PF00654.20 VDK82865.1 - 0.021 14.1 3.8 0.036 13.3 3.8 1.4 1 0 0 1 1 1 0 Voltage gated chloride channel DUF4220 PF13968.6 VDK82865.1 - 0.085 12.3 1.6 0.094 12.1 0.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4220) Phage_holin_8 PF16931.5 VDK82865.1 - 0.28 11.1 2.9 0.36 10.8 1.4 1.9 1 1 1 2 2 2 0 Putative phage holin Sdh_cyt PF01127.22 VDK82865.1 - 0.56 10.2 3.7 2.6 8.1 0.5 2.4 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1282 PF06930.12 VDK82865.1 - 1.6 8.5 10.7 0.088 12.6 5.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1282) PCAF_N PF06466.11 VDK82866.1 - 4.1e-39 134.6 0.2 6.8e-39 133.9 0.2 1.3 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain PF00439.25 VDK82866.1 - 8.2e-17 61.1 0.1 2.5e-16 59.5 0.1 1.9 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 VDK82866.1 - 1.3e-07 31.9 0.1 3.2e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 VDK82866.1 - 1.5e-05 24.9 0.2 3.1e-05 23.9 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 VDK82866.1 - 6.2e-05 23.3 1.4 0.00016 22.0 1.4 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Redoxin PF08534.10 VDK82866.1 - 0.069 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Redoxin VWA_N2 PF16164.5 VDK82866.1 - 0.12 12.6 0.3 0.27 11.4 0.3 1.5 1 0 0 1 1 1 0 VWA N-terminal SIS PF01380.22 VDK82868.1 - 1.4e-55 186.7 0.0 2e-33 115.0 0.0 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 VDK82868.1 - 2.6e-19 69.8 0.0 5.8e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 VDK82868.1 - 2.1e-14 53.5 0.2 8.3e-14 51.6 0.0 2.1 3 0 0 3 3 3 1 Glutamine amidotransferase domain GATase_4 PF13230.6 VDK82868.1 - 2.2e-06 26.8 0.1 4.2e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 VDK82868.1 - 0.00054 20.0 0.0 0.0078 16.2 0.0 2.5 2 0 0 2 2 2 1 SIS domain GATase_2 PF00310.21 VDK82868.1 - 0.13 10.9 0.0 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 Glutamine amidotransferases class-II B9-C2 PF07162.11 VDK82869.1 - 8.6e-07 29.3 0.0 8.8e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein SH2_2 PF14633.6 VDK82874.1 - 4.6e-78 261.5 2.4 4.6e-78 261.5 2.4 2.0 2 0 0 2 2 1 1 SH2 domain HHH_7 PF14635.6 VDK82874.1 - 3.3e-37 127.0 0.0 7.8e-37 125.8 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 VDK82874.1 - 2.4e-36 124.8 0.0 5.5e-36 123.6 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 VDK82874.1 - 7.4e-18 65.1 4.6 2.2e-17 63.5 4.6 1.9 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 Tex_N PF09371.10 VDK82874.1 - 4.6e-09 36.2 0.7 0.0048 16.6 0.0 3.1 2 1 1 3 3 3 2 Tex-like protein N-terminal domain SH2 PF00017.24 VDK82874.1 - 1e-07 32.0 0.1 2e-05 24.6 0.1 3.0 2 0 0 2 2 2 1 SH2 domain HHH_9 PF17674.1 VDK82874.1 - 3.5e-07 31.0 0.1 1.8e-06 28.8 0.1 2.4 1 0 0 1 1 1 1 HHH domain Tex_YqgF PF16921.5 VDK82874.1 - 4.7e-05 23.8 0.0 0.0001 22.8 0.0 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain S1 PF00575.23 VDK82874.1 - 7.7e-05 23.0 0.0 0.00018 21.8 0.0 1.7 1 0 0 1 1 1 1 S1 RNA binding domain HHH_3 PF12836.7 VDK82874.1 - 0.00021 21.5 0.0 0.0019 18.4 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif SPT6_acidic PF14632.6 VDK82874.1 - 0.012 16.1 33.3 0.012 16.1 33.3 5.9 1 1 3 4 4 2 0 Acidic N-terminal SPT6 DUF3464 PF11947.8 VDK82874.1 - 6 6.6 6.1 13 5.5 6.1 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 GAGA_bind PF06217.12 VDK82874.1 - 7.2 6.8 8.1 40 4.4 8.1 2.3 1 0 0 1 1 1 0 GAGA binding protein-like family Erf4 PF10256.9 VDK82875.1 - 1.2e-10 41.5 0.0 1.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family GKAP PF03359.13 VDK82876.1 - 7.6e-22 78.3 4.7 7.6e-22 78.3 4.7 2.1 3 0 0 3 3 3 1 Guanylate-kinase-associated protein (GKAP) protein SbcD_C PF12320.8 VDK82876.1 - 0.15 12.4 2.2 0.35 11.2 0.8 2.3 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain GEMIN8 PF15348.6 VDK82877.1 - 2.2e-24 87.0 14.8 5.4e-22 79.2 4.3 2.0 1 1 1 2 2 2 2 Gemini of Cajal bodies-associated protein 8 Wbp11 PF09429.10 VDK82877.1 - 1.9 8.9 8.8 2.4 8.6 0.9 3.0 3 0 0 3 3 3 0 WW domain binding protein 11 DUF1770 PF08589.10 VDK82877.1 - 9 7.3 9.5 51 4.9 6.5 2.7 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF1770) SHS2_Rpb7-N PF03876.17 VDK82878.1 - 0.0011 19.2 0.0 0.0021 18.4 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 HCO3_cotransp PF00955.21 VDK82884.1 - 6.3e-66 223.2 1.3 6.3e-66 223.2 1.3 1.4 2 0 0 2 2 2 1 HCO3- transporter family Cpn60_TCP1 PF00118.24 VDK82885.1 - 6.7e-161 536.2 1.3 7.6e-161 536.1 1.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cofilin_ADF PF00241.20 VDK82886.1 - 1.3e-29 102.4 0.2 1.6e-29 102.1 0.2 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2043 PF09740.9 VDK82887.1 - 3.2e-37 127.5 0.5 9.9e-37 125.9 0.1 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2043) PAF-AH_p_II PF03403.13 VDK82887.1 - 0.13 10.7 0.8 0.23 9.9 0.8 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Ocnus PF05005.15 VDK82888.1 - 8.3e-37 125.6 0.7 9.2e-37 125.5 0.7 1.0 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) ADK PF00406.22 VDK82888.1 - 0.077 13.1 0.0 0.88 9.7 0.0 1.9 1 1 1 2 2 2 0 Adenylate kinase Ocnus PF05005.15 VDK82889.1 - 1.6e-38 131.1 0.3 1.8e-38 131.0 0.3 1.0 1 0 0 1 1 1 1 Janus/Ocnus family (Ocnus) DUF148 PF02520.17 VDK82891.1 - 3e-12 46.6 9.9 0.0021 18.1 0.4 4.1 3 1 1 4 4 4 4 Domain of unknown function DUF148 Lipase_chap PF03280.14 VDK82891.1 - 5.6e-05 23.2 9.1 0.0044 17.0 2.1 3.6 2 2 1 3 3 3 2 Proteobacterial lipase chaperone protein RhoGAP PF00620.27 VDK82891.1 - 0.00057 19.7 6.5 0.36 10.6 0.2 3.7 1 1 3 4 4 4 2 RhoGAP domain Metal_resist PF13801.6 VDK82891.1 - 0.0018 18.5 0.2 14 5.9 0.1 3.3 3 0 0 3 3 3 1 Heavy-metal resistance Sec23_helical PF04815.15 VDK82891.1 - 0.017 15.0 0.2 0.051 13.4 0.0 2.0 2 1 0 2 2 2 0 Sec23/Sec24 helical domain DUF3886 PF13025.6 VDK82891.1 - 0.046 13.9 4.4 2.5 8.4 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3886) BID PF06393.11 VDK82891.1 - 0.11 12.0 2.4 0.28 10.7 0.1 2.3 2 1 0 2 2 2 0 BH3 interacting domain (BID) Ribosomal_S10 PF00338.22 VDK82892.1 - 0.011 15.9 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S10p/S20e Mod_r PF07200.13 VDK82894.1 - 9.5e-12 45.2 2.3 1.1e-11 45.0 2.3 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein RNB PF00773.19 VDK82894.1 - 0.024 14.0 0.4 0.026 13.8 0.4 1.1 1 0 0 1 1 1 0 RNB domain IKI3 PF04762.12 VDK82896.1 - 8.5e-156 520.5 0.1 1.1e-155 520.1 0.1 1.1 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 VDK82896.1 - 7.4e-08 32.6 0.1 0.011 16.0 0.0 4.0 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Pox_F15 PF04596.12 VDK82896.1 - 0.12 12.2 2.3 0.24 11.1 2.3 1.5 1 0 0 1 1 1 0 Poxvirus protein F15 Clathrin PF00637.20 VDK82898.1 - 0.00048 20.0 9.7 0.052 13.4 0.3 3.5 1 1 2 3 3 3 2 Region in Clathrin and VPS PhaP_Bmeg PF09602.10 VDK82898.1 - 0.026 14.5 0.3 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF1402 PF07182.11 VDK82898.1 - 0.069 12.2 0.2 0.1 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1402) Vps39_1 PF10366.9 VDK82898.1 - 0.45 10.8 2.8 28 5.1 0.2 2.8 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 VDK82898.1 - 3 8.2 6.2 5.2 7.4 0.7 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat DEAD PF00270.29 VDK82909.1 - 6e-30 104.3 0.0 1.1e-29 103.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK82909.1 - 5.5e-27 94.3 0.2 2.2e-26 92.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 VDK82909.1 - 0.00012 22.4 0.0 0.095 13.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 VDK82909.1 - 0.00088 19.3 0.0 0.0019 18.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 VDK82909.1 - 0.072 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Patched PF02460.18 VDK82911.1 - 5e-56 190.3 34.1 2.1e-29 102.2 8.7 3.3 2 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK82911.1 - 2e-34 118.7 5.2 2e-34 118.7 5.2 3.6 4 0 0 4 4 4 1 Sterol-sensing domain of SREBP cleavage-activation IL4Ra_N PF09238.10 VDK82911.1 - 0.032 14.5 0.4 8.7 6.8 0.2 2.8 2 0 0 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal Methyltransf_32 PF13679.6 VDK82916.1 - 9.5e-20 71.2 3.8 2.3e-19 70.0 3.8 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK82916.1 - 2.7e-08 34.4 0.1 5.8e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK82916.1 - 1.8e-07 31.1 0.4 4.5e-07 29.8 0.4 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK82916.1 - 3.8e-05 24.3 0.1 8.1e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK82916.1 - 4.8e-05 24.0 0.0 0.0001 23.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 VDK82916.1 - 0.0027 17.5 0.0 0.0044 16.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 VDK82916.1 - 0.0029 17.5 0.0 0.0051 16.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 VDK82916.1 - 0.0059 16.1 0.1 0.012 15.2 0.1 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 VDK82916.1 - 0.015 14.9 0.1 0.027 14.0 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 VDK82916.1 - 0.021 14.1 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 VDK82916.1 - 0.043 13.7 0.1 0.076 12.9 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 VDK82916.1 - 0.049 13.2 0.1 0.086 12.4 0.1 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_4 PF02390.17 VDK82916.1 - 0.07 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase NodS PF05401.11 VDK82916.1 - 0.083 12.5 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) MetW PF07021.12 VDK82916.1 - 0.14 11.7 0.3 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW U-box PF04564.15 VDK82917.1 - 0.04 14.1 0.1 0.076 13.2 0.1 1.4 1 0 0 1 1 1 0 U-box domain COPIIcoated_ERV PF07970.12 VDK82918.1 - 9.8e-34 117.1 0.1 1.7e-33 116.4 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 VDK82918.1 - 4.7e-26 91.0 0.3 1.2e-25 89.6 0.0 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) LIM PF00412.22 VDK82925.1 - 1.2e-54 182.3 69.6 3.1e-15 56.1 5.2 5.2 5 0 0 5 5 5 5 LIM domain Flavodoxin_4 PF12682.7 VDK82925.1 - 0.0078 15.9 0.2 0.061 13.0 0.0 2.1 2 0 0 2 2 2 1 Flavodoxin DUF2784 PF10861.8 VDK82926.1 - 0.065 13.3 0.0 0.072 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) Lung_7-TM_R PF06814.13 VDK82928.1 - 2.9e-61 207.3 13.4 3.7e-61 207.0 13.4 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 VDK82928.1 - 0.014 14.8 20.3 0.021 14.3 20.3 1.3 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain Kin17_mid PF10357.9 VDK82930.1 - 1.9e-44 150.6 6.0 1.9e-44 150.6 6.0 1.9 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein Rotamase_3 PF13616.6 VDK82930.1 - 3.8e-19 69.3 0.6 7e-18 65.3 0.1 3.1 2 1 0 2 2 2 1 PPIC-type PPIASE domain KN17_SH3 PF18131.1 VDK82930.1 - 5.6e-16 58.4 3.1 6.1e-14 51.9 0.2 2.9 3 0 0 3 3 3 2 KN17 SH3-like C-terminal domain Rotamase PF00639.21 VDK82930.1 - 1.3e-14 54.9 0.0 1.3e-14 54.9 0.0 2.6 3 1 0 3 3 3 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 VDK82930.1 - 0.00095 20.0 2.9 0.012 16.5 0.0 3.3 2 1 1 3 3 3 1 PPIC-type PPIASE domain zf-met PF12874.7 VDK82930.1 - 0.0044 17.4 6.5 0.013 15.9 6.5 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 VDK82930.1 - 0.21 12.0 7.3 0.21 11.9 2.0 3.0 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) CarbpepA_inh PF02977.15 VDK82930.1 - 3.6 7.5 6.9 3.5 7.5 3.4 2.3 2 0 0 2 2 2 0 Carboxypeptidase A inhibitor Aminotran_1_2 PF00155.21 VDK82931.1 - 1.1e-77 261.6 0.0 1.3e-77 261.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Adap_comp_sub PF00928.21 VDK82933.1 - 4.3e-72 242.7 0.0 5.2e-72 242.4 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 VDK82933.1 - 0.0028 17.6 0.5 0.0063 16.4 0.5 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Gar1 PF04410.14 VDK82934.1 - 3.2e-36 124.4 0.2 8.4e-36 123.1 0.0 1.8 2 0 0 2 2 2 1 Gar1/Naf1 RNA binding region RDD PF06271.12 VDK82935.1 - 1.7e-08 34.8 0.9 1.3e-07 31.9 0.9 2.0 1 1 0 1 1 1 1 RDD family Snapin_Pallidin PF14712.6 VDK82936.1 - 1.1e-09 38.6 0.2 1.6e-09 38.0 0.2 1.3 1 0 0 1 1 1 1 Snapin/Pallidin GIT_CC PF16559.5 VDK82936.1 - 0.017 15.0 0.3 0.022 14.6 0.3 1.3 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ADIP PF11559.8 VDK82936.1 - 0.037 14.1 1.7 0.04 14.0 1.7 1.0 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Prefoldin PF02996.17 VDK82936.1 - 0.087 12.7 0.2 0.12 12.3 0.2 1.2 1 0 0 1 1 1 0 Prefoldin subunit CLZ PF16526.5 VDK82936.1 - 0.21 11.9 2.3 0.34 11.3 2.3 1.5 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels XhlA PF10779.9 VDK82936.1 - 0.49 10.6 1.8 0.31 11.3 0.4 1.5 2 0 0 2 2 2 0 Haemolysin XhlA Cadherin PF00028.17 VDK82940.1 - 0.00026 21.4 0.0 1.1 9.8 0.0 3.3 3 0 0 3 3 3 2 Cadherin domain N_BRCA1_IG PF16158.5 VDK82940.1 - 0.093 13.5 0.0 0.18 12.5 0.0 1.5 1 0 0 1 1 1 0 Ig-like domain from next to BRCA1 gene SH3_16 PF18348.1 VDK82940.1 - 0.21 11.4 0.1 0.44 10.4 0.1 1.5 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain Cadherin PF00028.17 VDK82941.1 - 2.1e-125 409.5 25.0 6e-15 55.5 0.2 12.5 12 1 0 12 12 12 12 Cadherin domain Cadherin_3 PF16184.5 VDK82941.1 - 3.5e-07 30.2 11.4 6.6 6.8 0.0 9.0 8 1 0 8 8 8 3 Cadherin-like RET_CLD1 PF17756.1 VDK82941.1 - 1.1e-06 29.0 0.0 0.032 14.5 0.0 4.1 5 0 0 5 5 5 2 RET Cadherin like domain 1 Cadherin_pro PF08758.11 VDK82941.1 - 8.8e-05 22.6 0.1 0.0028 17.8 0.0 3.7 4 0 0 4 4 4 1 Cadherin prodomain like Phosphorylase PF00343.20 VDK82945.1 - 0 1033.3 0.0 0 1033.0 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Ank_2 PF12796.7 VDK82946.1 - 1.5e-17 63.9 2.1 1.4e-09 38.4 0.6 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 VDK82946.1 - 1.6e-16 59.9 0.5 6.8e-05 23.1 0.0 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 VDK82946.1 - 2.1e-15 56.9 0.7 2e-06 28.2 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK82946.1 - 4.2e-15 54.3 0.4 9.7e-06 25.6 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 VDK82946.1 - 1.3e-13 50.8 0.2 4.4e-07 30.0 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ion_trans PF00520.31 VDK82946.1 - 3.6e-09 36.2 20.6 5.5e-09 35.6 20.6 1.2 1 0 0 1 1 1 1 Ion transport protein DnaJ PF00226.31 VDK82948.1 - 6.4e-21 74.3 0.5 1.2e-20 73.4 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain Nmad5 PF18757.1 VDK82948.1 - 0.13 12.4 1.8 0.22 11.7 1.8 1.3 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 TM_helix PF05552.12 VDK82948.1 - 0.48 10.4 1.8 0.88 9.6 1.8 1.3 1 0 0 1 1 1 0 Conserved TM helix DnaJ PF00226.31 VDK82949.1 - 3.6e-18 65.4 5.9 6.5e-18 64.6 5.9 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ PF00226.31 VDK82951.1 - 1.5e-15 57.1 1.3 4e-15 55.7 1.3 1.8 1 1 0 1 1 1 1 DnaJ domain UPF0767 PF15990.5 VDK82952.1 - 5.6e-10 39.2 0.0 6.3e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 UPF0767 family HECA PF15353.6 VDK82957.1 - 3.3e-06 27.3 0.0 3.4e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Headcase protein family homologue Vps16_C PF04840.12 VDK82958.1 - 2.3e-06 26.9 4.5 0.0023 17.0 0.5 2.4 2 1 0 2 2 2 2 Vps16, C-terminal region Vps16_C PF04840.12 VDK82959.1 - 2.9e-09 36.4 7.8 2e-05 23.8 1.5 2.4 2 1 0 2 2 2 2 Vps16, C-terminal region HECA PF15353.6 VDK82960.1 - 3.3e-06 27.3 0.0 3.4e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Headcase protein family homologue MMS19_N PF14500.6 VDK82961.1 - 1.5e-26 93.6 7.6 2.6e-16 60.0 0.7 3.6 2 1 1 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II DUF4042 PF13251.6 VDK82961.1 - 0.016 15.0 0.5 0.016 15.0 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4042) HEAT PF02985.22 VDK82961.1 - 0.18 12.2 1.5 0.6 10.5 0.2 2.7 2 0 0 2 2 2 0 HEAT repeat COX17 PF05051.13 VDK82961.1 - 0.92 9.9 4.1 0.61 10.5 1.0 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) TMEM100 PF16311.5 VDK82972.1 - 0.00044 19.8 0.9 0.00063 19.4 0.9 1.2 1 0 0 1 1 1 1 Transmembrane protein 100 PRIMA1 PF16101.5 VDK82972.1 - 0.0061 16.6 1.0 0.0091 16.0 1.0 1.2 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 Pox_P21 PF05313.12 VDK82972.1 - 0.0061 16.2 0.1 0.0066 16.1 0.1 1.1 1 0 0 1 1 1 1 Poxvirus P21 membrane protein E1-E2_ATPase PF00122.20 VDK82972.1 - 0.013 15.0 0.1 0.015 14.8 0.1 1.1 1 0 0 1 1 1 0 E1-E2 ATPase GTP_EFTU PF00009.27 VDK82973.1 - 2.5e-50 170.7 0.0 4e-50 170.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 VDK82973.1 - 4.2e-17 61.9 0.0 1.1e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 VDK82973.1 - 2.6e-06 27.7 0.1 6.5e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 VDK82973.1 - 0.0028 17.4 0.0 0.012 15.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV FeoB_N PF02421.18 VDK82973.1 - 0.0039 16.7 0.2 0.0082 15.7 0.2 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 VDK82973.1 - 0.013 15.6 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase PDZ PF00595.24 VDK82973.1 - 0.079 13.3 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Endosulfine PF04667.17 VDK82975.1 - 1.3e-13 50.9 1.0 2.4e-13 50.0 1.0 1.5 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Anillin_N PF16018.5 VDK82975.1 - 0.073 13.7 0.7 0.24 12.0 0.2 2.1 2 0 0 2 2 2 0 Anillin N-terminus TYW3 PF02676.14 VDK82976.1 - 0.046 13.1 0.1 0.14 11.5 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase TYW3 Glycolytic PF00274.19 VDK82982.1 - 1e-177 590.2 0.0 1.1e-177 590.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I SapC PF07277.11 VDK82982.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 SapC Med1 PF10744.9 VDK82985.1 - 4.3e-05 22.8 0.0 0.00016 20.9 0.0 2.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 UBX PF00789.20 VDK82986.1 - 2.5e-12 46.8 0.0 5.1e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 UBX domain Hid1 PF12722.7 VDK82986.1 - 0.0053 15.0 5.9 0.007 14.6 5.9 1.2 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Membralin PF09746.9 VDK82986.1 - 0.96 8.4 6.9 5.9 5.8 7.5 1.9 2 0 0 2 2 2 0 Tumour-associated protein HLH PF00010.26 VDK82987.1 - 7.3e-16 57.9 1.2 1.7e-15 56.7 1.2 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain COE1_HLH PF16423.5 VDK82987.1 - 0.0012 18.5 0.0 0.0023 17.6 0.0 1.4 1 0 0 1 1 1 1 Transcription factor COE1 helix-loop-helix domain Rrp15p PF07890.12 VDK82987.1 - 0.21 11.9 3.9 0.46 10.8 3.9 1.5 1 0 0 1 1 1 0 Rrp15p BBS2_Mid PF14783.6 VDK82988.1 - 0.0018 18.3 0.0 0.0041 17.1 0.0 1.6 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region LemA PF04011.12 VDK82988.1 - 0.0043 16.9 0.0 0.0089 15.9 0.0 1.4 1 0 0 1 1 1 1 LemA family PHTB1_N PF14727.6 VDK82988.1 - 0.026 13.9 0.0 0.28 10.5 0.0 2.2 2 0 0 2 2 2 0 PTHB1 N-terminus DUF4686 PF15742.5 VDK82988.1 - 0.052 12.7 1.3 5.8 5.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) CENP-F_leu_zip PF10473.9 VDK82988.1 - 0.066 13.2 1.8 6.7 6.7 0.2 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF349 PF03993.12 VDK82988.1 - 0.11 12.8 0.0 0.25 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) EzrA PF06160.12 VDK82988.1 - 0.49 8.5 3.8 1.3 7.1 0.3 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Pkinase PF00069.25 VDK83001.1 - 6.2e-63 212.6 0.0 9e-63 212.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK83001.1 - 2.8e-33 115.3 0.0 4.4e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 VDK83001.1 - 3.8e-08 33.4 0.0 0.01 16.0 0.0 3.4 3 0 0 3 3 3 2 POLO box duplicated region Pkinase_fungal PF17667.1 VDK83001.1 - 3.6e-07 29.3 0.0 5.6e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 VDK83001.1 - 0.00075 18.9 0.0 0.0049 16.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 VDK83001.1 - 0.00096 18.2 0.0 0.0017 17.3 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 VDK83001.1 - 0.0022 18.0 0.0 0.0043 17.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 VDK83001.1 - 0.0033 17.1 0.0 0.0056 16.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 VDK83001.1 - 0.067 12.8 0.1 0.41 10.2 0.0 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase C2 PF00168.30 VDK83002.1 - 4.5e-58 193.9 0.1 2e-30 105.1 0.1 2.3 2 0 0 2 2 2 2 C2 domain Nucleoside_tran PF01733.18 VDK83002.1 - 0.0015 18.0 0.0 0.0029 17.1 0.0 1.4 1 0 0 1 1 1 1 Nucleoside transporter CEP76-C2 PF15627.6 VDK83002.1 - 0.0028 17.2 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 2 CEP76 C2 domain PTEN_C2 PF10409.9 VDK83002.1 - 0.012 15.3 0.9 6.6 6.5 0.0 3.2 2 1 1 3 3 3 0 C2 domain of PTEN tumour-suppressor protein MFS_1 PF07690.16 VDK83002.1 - 0.018 14.0 0.0 0.026 13.5 0.0 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily PMT_2 PF13231.6 VDK83002.1 - 0.028 14.7 0.2 0.044 14.0 0.2 1.3 1 0 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase FeoB_associated PF12669.7 VDK83002.1 - 0.17 12.3 0.1 0.17 12.3 0.1 2.0 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein DUF2207 PF09972.9 VDK83002.1 - 0.19 10.5 1.5 0.25 10.0 0.5 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DASH_Hsk3 PF08227.11 VDK83002.1 - 0.66 10.4 2.7 10 6.6 0.9 2.4 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Homeodomain PF00046.29 VDK83006.1 - 3.8e-09 36.3 0.2 6.7e-09 35.5 0.2 1.4 1 0 0 1 1 1 1 Homeodomain SOBP PF15279.6 VDK83007.1 - 0.4 11.3 8.3 0.58 10.7 8.3 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Apt1 PF10351.9 VDK83007.1 - 1 8.1 13.4 1.3 7.8 13.4 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain GREB1 PF15782.5 VDK83007.1 - 2.5 5.1 12.4 2.8 4.9 12.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer WD40 PF00400.32 VDK83022.1 - 2.7e-12 47.0 5.9 0.081 13.8 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK83022.1 - 0.0016 18.7 0.1 1.3 9.3 0.0 4.4 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain fn3 PF00041.21 VDK83023.1 - 2.4e-18 66.2 11.4 3.9e-08 33.5 0.1 5.4 4 1 0 4 4 4 3 Fibronectin type III domain WAP PF00095.21 VDK83023.1 - 3.2e-08 33.8 14.3 3.2e-08 33.8 14.3 2.4 3 0 0 3 3 3 1 WAP-type (Whey Acidic Protein) 'four-disulfide core' Glyco_hydro_31 PF01055.26 VDK83026.1 - 1.1e-42 146.8 2.6 2.4e-41 142.3 2.6 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Med13_C PF06333.12 VDK83028.1 - 1.1e-92 310.8 0.0 1.1e-92 310.8 0.0 3.5 4 0 0 4 4 4 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 VDK83028.1 - 5e-30 105.1 0.5 3.6e-28 99.0 0.0 3.0 3 0 0 3 3 3 1 MID domain of medPIWI Med13_N PF11597.8 VDK83028.1 - 1.1e-24 87.5 2.0 2.4e-24 86.3 2.0 1.6 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal zf-ANAPC11 PF12861.7 VDK83042.1 - 1.9e-29 101.5 12.0 2.5e-29 101.2 12.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 VDK83042.1 - 1.3e-19 70.3 15.3 2.1e-19 69.5 15.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 VDK83042.1 - 4.7e-05 23.6 21.2 0.00014 22.1 18.6 2.5 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 VDK83042.1 - 0.0023 17.8 14.8 0.012 15.4 14.8 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK83042.1 - 0.0023 17.9 12.9 0.0061 16.6 10.6 2.3 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 VDK83042.1 - 0.015 15.5 3.9 0.015 15.5 3.9 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 VDK83042.1 - 3 7.7 17.1 22 4.9 17.1 2.2 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 VDK83042.1 - 4 7.5 16.8 15 5.6 16.8 2.1 1 1 0 1 1 1 0 zinc-RING finger domain RRM_1 PF00076.22 VDK83044.1 - 0.0022 17.8 0.0 0.0055 16.5 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Viral_Rep PF02407.16 VDK83044.1 - 0.043 14.1 0.3 0.13 12.5 0.1 2.0 2 0 0 2 2 2 0 Putative viral replication protein DUF588 PF04535.12 VDK83045.1 - 0.023 14.5 1.7 0.052 13.3 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF588) DUF4131 PF13567.6 VDK83045.1 - 0.61 9.7 7.8 0.81 9.3 2.3 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF202 PF02656.15 VDK83045.1 - 2.1 8.8 11.9 0.8 10.2 1.5 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF202) DUF4728 PF15860.5 VDK83045.1 - 4.1 8.1 15.4 0.77 10.5 8.8 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4728) DEAD PF00270.29 VDK83048.1 - 1.3e-47 161.9 0.0 1.8e-46 158.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK83048.1 - 1.1e-29 103.0 0.1 7e-29 100.4 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK83048.1 - 0.00014 21.9 0.0 0.0038 17.2 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 VDK83048.1 - 0.031 14.6 0.0 0.86 9.9 0.0 2.9 1 1 1 2 2 2 0 AAA domain zf-CCHC PF00098.23 VDK83048.1 - 0.12 12.5 2.0 0.21 11.7 2.0 1.4 1 0 0 1 1 1 0 Zinc knuckle preATP-grasp_3 PF18301.1 VDK83053.1 - 0.053 13.8 0.0 0.053 13.8 0.0 1.1 1 0 0 1 1 1 0 pre ATP-grasp 3 domain MutS_V PF00488.21 VDK83054.1 - 2.5e-36 125.5 0.0 7.1e-20 71.8 0.0 2.7 1 1 1 2 2 2 2 MutS domain V MutS_III PF05192.18 VDK83054.1 - 6.3e-24 85.3 3.1 2.3e-23 83.4 3.1 2.0 1 1 0 1 1 1 1 MutS domain III MutS_II PF05188.17 VDK83054.1 - 3.6e-11 43.5 0.3 1.2e-10 41.8 0.2 2.0 1 1 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 VDK83054.1 - 1.4e-05 25.4 0.0 4.6e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 MutS family domain IV AAA_23 PF13476.6 VDK83054.1 - 0.0027 18.2 0.6 0.021 15.3 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_27 PF13514.6 VDK83054.1 - 0.015 14.9 0.1 0.054 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain DUF3671 PF12420.8 VDK83054.1 - 0.03 14.4 0.7 0.078 13.1 0.7 1.8 1 1 0 1 1 1 0 Protein of unknown function AAA_29 PF13555.6 VDK83054.1 - 0.15 11.8 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pkinase PF00069.25 VDK83055.1 - 4.9e-57 193.3 0.0 7.6e-57 192.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK83055.1 - 2.4e-23 82.7 0.0 2.4e-23 82.7 0.0 1.9 3 0 0 3 3 3 1 Protein tyrosine kinase APH PF01636.23 VDK83055.1 - 0.024 14.5 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 VDK83056.1 - 4.8e-25 87.3 3.8 0.0001 23.0 0.0 7.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK83056.1 - 1.1e-11 44.8 0.1 0.7 10.2 0.0 6.3 2 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK83056.1 - 0.02 13.9 0.0 5.3 5.9 0.0 2.5 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 VDK83056.1 - 0.45 9.1 4.0 4.8 5.7 0.2 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF630 PF04783.12 VDK83057.1 - 1.6 8.9 6.4 0.12 12.6 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF630) Amino_oxidase PF01593.24 VDK83062.1 - 3.2e-10 39.9 0.0 2.3e-09 37.1 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 VDK83062.1 - 1.5e-05 25.2 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 VDK83062.1 - 0.051 13.6 0.2 0.1 12.6 0.1 1.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lustrin_cystein PF14625.6 VDK83063.1 - 4.2e-06 27.0 2.4 7e-06 26.3 2.4 1.4 1 0 0 1 1 1 1 Lustrin, cysteine-rich repeated domain InvH PF04741.12 VDK83063.1 - 0.046 13.7 0.0 0.051 13.5 0.0 1.2 1 0 0 1 1 1 0 InvH outer membrane lipoprotein ATG16 PF08614.11 VDK83064.1 - 0.003 17.8 13.1 0.003 17.8 13.1 3.1 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) FAM76 PF16046.5 VDK83064.1 - 0.19 11.1 30.1 0.03 13.7 7.4 3.1 1 1 2 3 3 3 0 FAM76 protein ERM PF00769.19 VDK83064.1 - 0.42 10.4 43.3 0.054 13.3 8.9 2.8 2 1 1 3 3 3 0 Ezrin/radixin/moesin family FPP PF05911.11 VDK83064.1 - 2.5 6.2 32.5 0.025 12.8 9.8 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil B56 PF01603.20 VDK83066.1 - 3.2e-184 612.7 9.2 4.1e-184 612.3 9.2 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 VDK83066.1 - 0.016 15.1 2.7 0.27 11.1 0.2 2.9 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal RIH_assoc PF08454.11 VDK83066.1 - 0.041 13.7 0.4 0.64 9.9 0.0 2.4 2 0 0 2 2 2 0 RyR and IP3R Homology associated GST_C_3 PF14497.6 VDK83067.1 - 3.8e-09 36.6 0.1 6.9e-09 35.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 VDK83067.1 - 5.3e-07 30.0 0.0 8.4e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 VDK83067.1 - 1.7e-06 28.1 0.0 2.4e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 VDK83067.1 - 0.0032 17.8 0.0 0.0068 16.7 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 VDK83067.1 - 0.0075 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ly-6_related PF06579.12 VDK83069.1 - 5.8e-42 142.9 3.4 7.8e-42 142.5 3.4 1.2 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein QVR PF17064.5 VDK83069.1 - 0.062 13.6 9.7 0.52 10.6 4.3 3.2 1 1 1 2 2 2 0 Sleepless protein DUF4125 PF13526.6 VDK83073.1 - 0.0015 18.2 1.0 0.0016 18.1 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4125) RNase_H2-Ydr279 PF09468.10 VDK83073.1 - 0.0072 16.5 0.7 0.008 16.4 0.7 1.1 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain ING PF12998.7 VDK83073.1 - 0.0081 16.7 1.2 0.0096 16.5 1.2 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding DUF3220 PF11516.8 VDK83073.1 - 0.056 13.7 0.0 0.073 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) Fungal_TACC PF12709.7 VDK83073.1 - 0.057 13.9 3.0 0.091 13.2 3.0 1.5 1 1 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins Abi_C PF14355.6 VDK83073.1 - 0.068 13.3 0.0 0.095 12.8 0.0 1.2 1 0 0 1 1 1 0 Abortive infection C-terminus Neur_chan_LBD PF02931.23 VDK83074.1 - 5e-73 245.1 0.8 7.8e-73 244.5 0.8 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK83074.1 - 5.2e-44 151.1 1.2 7.7e-44 150.5 1.2 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF2678 PF10856.8 VDK83074.1 - 0.016 15.1 1.8 0.038 13.9 1.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) PDZ PF00595.24 VDK83076.1 - 1.1e-14 54.5 0.5 3.4e-14 53.0 0.5 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK83076.1 - 6.4e-07 29.1 0.0 2e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 PDZ domain PolyA_pol PF01743.20 VDK83077.1 - 1.5e-23 83.5 0.4 8.3e-12 45.6 0.1 2.7 1 1 1 2 2 2 2 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 VDK83077.1 - 4e-05 23.3 0.0 0.00016 21.4 0.0 2.0 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 VDK83077.1 - 0.00044 20.3 0.2 0.0007 19.6 0.2 1.3 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative AAA PF00004.29 VDK83078.1 - 3.6e-38 131.0 0.0 7.3e-38 130.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK83078.1 - 8e-11 41.6 0.8 6.9e-10 38.6 0.0 2.7 3 0 0 3 3 3 1 AAA+ lid domain RuvB_N PF05496.12 VDK83078.1 - 8.2e-06 25.7 0.0 2.1e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 VDK83078.1 - 1.3e-05 25.4 0.0 2.7e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 VDK83078.1 - 6.2e-05 23.0 0.2 0.00075 19.5 0.2 2.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 VDK83078.1 - 6.4e-05 22.3 0.0 0.00018 20.9 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 VDK83078.1 - 0.00016 20.9 0.0 0.00043 19.5 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 VDK83078.1 - 0.00019 21.9 0.5 0.14 12.5 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 VDK83078.1 - 0.00034 20.9 0.5 0.022 15.0 0.0 2.8 2 1 1 3 3 3 1 AAA domain Vps4_C PF09336.10 VDK83078.1 - 0.00071 19.5 0.0 0.0027 17.7 0.0 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_14 PF13173.6 VDK83078.1 - 0.0011 19.0 0.1 0.0062 16.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 VDK83078.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 VDK83078.1 - 0.0094 15.3 0.2 0.045 13.1 0.2 2.0 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 VDK83078.1 - 0.012 15.0 0.0 4.5 6.6 0.0 2.5 1 1 1 2 2 2 0 Bacterial TniB protein MIT PF04212.18 VDK83078.1 - 0.012 15.6 1.5 0.012 15.6 1.5 2.4 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain AAA_18 PF13238.6 VDK83078.1 - 0.013 16.1 0.0 0.03 14.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 VDK83078.1 - 0.022 15.1 0.0 0.11 12.9 0.0 2.3 2 0 0 2 2 2 0 RNA helicase PELOTA_1 PF15608.6 VDK83078.1 - 0.063 13.2 0.4 0.21 11.5 0.3 2.0 1 1 0 1 1 1 0 PELOTA RNA binding domain TPR_8 PF13181.6 VDK83078.1 - 0.064 13.5 0.0 0.22 11.8 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat AAA_33 PF13671.6 VDK83078.1 - 0.069 13.3 0.0 0.21 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 VDK83078.1 - 0.073 12.6 0.0 0.3 10.6 0.0 2.0 2 1 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 VDK83078.1 - 0.14 11.5 1.0 13 5.0 0.0 2.7 2 1 1 3 3 3 0 KaiC ABC_membrane PF00664.23 VDK83088.1 - 6.3e-39 134.3 11.5 8.4e-39 133.9 11.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 VDK83088.1 - 1.4e-32 113.1 0.2 3.1e-32 112.0 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 VDK83088.1 - 5.1e-08 32.6 0.7 1.1e-06 28.2 0.7 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 VDK83088.1 - 3.3e-06 27.6 0.0 8.1e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 VDK83088.1 - 0.00062 18.7 0.0 0.0011 17.9 0.0 1.3 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_29 PF13555.6 VDK83088.1 - 0.0012 18.5 0.1 0.0027 17.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 VDK83088.1 - 0.002 18.4 0.0 0.013 15.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 VDK83088.1 - 0.0044 16.3 0.0 0.011 15.0 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_21 PF13304.6 VDK83088.1 - 0.0048 16.7 0.1 0.047 13.5 0.0 2.1 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 VDK83088.1 - 0.022 14.5 0.5 0.19 11.4 0.1 2.6 2 1 0 2 2 2 0 AAA domain PRK PF00485.18 VDK83088.1 - 0.036 13.8 0.1 0.76 9.5 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family TniB PF05621.11 VDK83088.1 - 0.037 13.4 0.0 0.26 10.7 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_23 PF13476.6 VDK83088.1 - 0.041 14.4 0.1 0.15 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 VDK83088.1 - 0.089 12.5 0.8 0.12 12.1 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain Ribosomal_L10 PF00466.20 VDK83089.1 - 7.3e-23 80.6 0.1 2.2e-22 79.1 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 VDK83089.1 - 1.8e-20 72.7 0.2 1.1e-19 70.2 0.1 2.1 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 VDK83089.1 - 2.4e-15 56.9 6.5 2.4e-15 56.9 6.5 1.7 2 0 0 2 2 2 1 60s Acidic ribosomal protein TCTP PF00838.17 VDK83090.1 - 3.4e-46 157.6 0.5 3.9e-46 157.4 0.5 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF327 PF03885.13 VDK83090.1 - 0.01 15.8 0.9 0.04 13.9 0.9 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF327) SapB_1 PF05184.15 VDK83090.1 - 0.08 13.0 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Saposin-like type B, region 1 DUF5433 PF17498.2 VDK83091.1 - 0.024 14.9 0.1 0.093 12.9 0.1 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5433) DAGK_acc PF00609.19 VDK83093.1 - 5.3e-53 179.6 0.0 8.6e-53 178.9 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain RA PF00788.23 VDK83093.1 - 1.3e-27 96.2 0.4 1.2e-13 51.5 0.1 2.5 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain DAGK_cat PF00781.24 VDK83093.1 - 2e-22 79.2 0.0 4.6e-22 78.0 0.0 1.7 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain TUG-UBL1 PF11470.8 VDK83093.1 - 0.0003 20.9 0.0 1.5 9.1 0.0 3.1 2 0 0 2 2 2 2 TUG ubiquitin-like domain DUF2188 PF09954.9 VDK83093.1 - 0.021 14.9 0.2 0.059 13.5 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) Cwf_Cwc_15 PF04889.12 VDK83093.1 - 0.024 14.4 1.2 0.042 13.6 1.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Desmo_N PF06771.11 VDK83093.1 - 0.082 13.3 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Viral Desmoplakin N-terminus VMA21 PF09446.10 VDK83098.1 - 4.5e-10 39.5 14.6 1.1e-09 38.3 14.6 1.6 1 0 0 1 1 1 1 VMA21-like domain ORC3_N PF07034.11 VDK83098.1 - 2.6e-06 26.8 0.1 4.7e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus DUF3021 PF11457.8 VDK83098.1 - 0.0082 16.5 2.5 0.0082 16.5 2.5 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3021) Cytomega_TRL10 PF06084.11 VDK83098.1 - 0.13 12.2 0.2 6 6.9 0.2 2.4 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein RseC_MucC PF04246.12 VDK83098.1 - 0.56 10.2 3.3 1 9.3 3.3 1.4 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC PDCD2_C PF04194.13 VDK83102.1 - 9.6e-42 143.0 0.0 4.7e-40 137.5 0.0 2.7 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 VDK83102.1 - 4.6e-10 39.4 18.1 4.6e-10 39.4 18.1 3.2 5 0 0 5 5 5 1 MYND finger VMA21 PF09446.10 VDK83102.1 - 0.057 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 VMA21-like domain DUF1858 PF08984.11 VDK83103.1 - 0.056 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) Homeodomain PF00046.29 VDK83104.1 - 2.3e-21 75.4 4.5 3.3e-21 74.9 4.5 1.2 1 0 0 1 1 1 1 Homeodomain Mago-bind PF09282.10 VDK83105.1 - 4.5e-15 55.2 1.2 7.9e-15 54.4 1.2 1.4 1 0 0 1 1 1 1 Mago binding DUF1018 PF06252.12 VDK83105.1 - 0.063 14.3 0.3 0.12 13.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) PHD PF00628.29 VDK83106.1 - 6.1e-08 32.4 10.0 9.8e-08 31.8 10.0 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 VDK83106.1 - 0.0004 20.6 2.4 0.00092 19.4 2.4 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 VDK83106.1 - 0.0034 17.5 0.3 0.0065 16.6 0.3 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain ING PF12998.7 VDK83106.1 - 0.0072 16.9 1.8 0.013 16.1 0.5 1.9 1 1 1 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding CAS_CSE1 PF03378.15 VDK83106.1 - 0.033 12.7 0.0 0.045 12.2 0.0 1.1 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus zf-RING-like PF08746.11 VDK83106.1 - 0.15 12.4 5.8 0.26 11.6 5.8 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_2 PF13639.6 VDK83106.1 - 0.41 11.0 8.7 0.68 10.3 8.7 1.3 1 0 0 1 1 1 0 Ring finger domain zf-4CXXC_R1 PF10497.9 VDK83106.1 - 4.8 7.5 10.3 17 5.7 10.3 1.8 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 GCN5L1 PF06320.13 VDK83107.1 - 1.7e-42 144.2 12.7 1.9e-42 144.0 12.7 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Erf4 PF10256.9 VDK83107.1 - 0.023 14.8 0.9 0.13 12.4 0.6 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family DUF4264 PF14084.6 VDK83107.1 - 0.034 13.8 0.0 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4264) Peptidase_M17 PF00883.21 VDK83107.1 - 0.039 13.2 0.6 0.045 13.0 0.6 1.0 1 0 0 1 1 1 0 Cytosol aminopeptidase family, catalytic domain DUF2009 PF09418.10 VDK83107.1 - 0.25 10.4 5.3 0.28 10.2 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) DUF4446 PF14584.6 VDK83107.1 - 0.33 10.9 4.4 0.13 12.2 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF1664 PF07889.12 VDK83107.1 - 0.54 10.3 6.8 0.62 10.1 3.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 VDK83107.1 - 1 9.9 11.3 11 6.6 11.3 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region Arm-DNA-bind_5 PF17293.2 VDK83107.1 - 4.3 7.8 8.0 0.65 10.5 2.1 2.0 1 1 1 2 2 2 0 Arm DNA-binding domain ASD2 PF08687.11 VDK83108.1 - 7e-14 52.1 16.5 7e-14 52.1 16.5 2.1 2 1 0 2 2 2 1 Apx/Shroom domain ASD2 GRAB PF10375.9 VDK83108.1 - 0.083 12.8 0.3 0.18 11.7 0.3 1.6 1 0 0 1 1 1 0 GRIP-related Arf-binding domain ABC_tran_CTD PF16326.5 VDK83108.1 - 0.5 10.7 7.5 0.54 10.5 4.2 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain Laminin_EGF PF00053.24 VDK83113.1 - 1e-08 35.2 27.6 1e-07 32.0 17.4 2.4 2 0 0 2 2 2 2 Laminin EGF domain MCPsignal PF00015.21 VDK83113.1 - 0.0099 15.7 5.4 0.0099 15.7 5.4 5.9 3 1 3 6 6 6 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2935 PF11155.8 VDK83113.1 - 0.059 13.7 15.8 1.9e+03 -0.8 15.8 4.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) Apo-CIII PF05778.12 VDK83113.1 - 0.07 12.8 6.0 0.71 9.6 0.1 4.3 4 0 0 4 4 4 0 Apolipoprotein CIII (Apo-CIII) DASH_Dam1 PF08653.10 VDK83113.1 - 0.98 9.3 5.6 1.3 8.9 0.1 3.5 3 0 0 3 3 3 0 DASH complex subunit Dam1 Latarcin PF10279.9 VDK83113.1 - 4.9 7.6 15.0 0.45 10.9 0.1 5.0 3 3 0 3 3 3 0 Latarcin precursor Alanine_zipper PF11839.8 VDK83113.1 - 7.5 7.0 82.4 0.13 12.7 10.3 8.1 7 1 1 8 8 8 0 Alanine-zipper, major outer membrane lipoprotein Thioredoxin PF00085.20 VDK83114.1 - 4e-27 94.2 0.0 5.7e-27 93.7 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 VDK83114.1 - 3.6e-06 27.4 0.0 1e-05 25.9 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 VDK83114.1 - 6.5e-05 23.0 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 VDK83114.1 - 7.2e-05 23.0 0.1 0.43 11.0 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like Thioredoxin_9 PF14595.6 VDK83114.1 - 0.0057 16.4 0.0 0.0078 16.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 VDK83114.1 - 0.015 15.2 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_3 PF13192.6 VDK83114.1 - 0.085 12.9 1.1 0.27 11.3 0.3 2.0 1 1 1 2 2 2 0 Thioredoxin domain Imm6 PF14434.6 VDK83116.1 - 0.00073 19.5 0.7 0.76 9.7 0.1 2.5 1 1 1 2 2 2 2 Immunity protein Imm6 Peptidase_M3_N PF08439.10 VDK83116.1 - 0.036 14.4 1.2 0.16 12.2 0.6 2.5 1 1 1 2 2 2 0 Oligopeptidase F Acetyltransf_10 PF13673.7 VDK83117.1 - 1.6e-07 31.3 0.0 2e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 VDK83117.1 - 3.1e-06 27.5 0.1 4e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 VDK83117.1 - 0.00012 22.3 0.2 0.00018 21.7 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 VDK83117.1 - 0.022 15.4 0.3 0.036 14.8 0.2 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Cupin_8 PF13621.6 VDK83118.1 - 4.5e-46 157.6 0.0 5.8e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 VDK83118.1 - 2.8e-08 33.6 0.0 5.2e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 VDK83118.1 - 0.0011 19.4 0.0 0.0027 18.1 0.0 1.8 1 1 0 1 1 1 1 JmjC domain, hydroxylase Tht1 PF04163.12 VDK83118.1 - 0.16 10.7 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein FKBP_N PF01346.18 VDK83119.1 - 0.074 14.0 2.2 0.091 13.7 2.2 1.2 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Spt20 PF12090.8 VDK83119.1 - 0.11 12.1 4.3 0.11 12.1 4.3 1.1 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 VDK83119.1 - 4.2 6.1 5.8 4.2 6.1 5.8 1.0 1 0 0 1 1 1 0 Androgen receptor DUF4407 PF14362.6 VDK83124.1 - 0.003 17.0 6.7 0.0041 16.5 6.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF1664 PF07889.12 VDK83124.1 - 0.0037 17.3 3.2 0.0037 17.3 3.2 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 VDK83124.1 - 0.0042 17.1 20.7 0.012 15.7 14.8 2.1 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 VDK83124.1 - 0.0083 15.0 15.3 0.011 14.7 15.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein V-SNARE PF05008.15 VDK83124.1 - 0.079 13.3 10.0 0.48 10.8 5.5 2.5 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Bacillus_HBL PF05791.11 VDK83124.1 - 0.095 12.5 4.8 0.21 11.4 1.6 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) NleF_casp_inhib PF16809.5 VDK83124.1 - 0.12 12.3 10.7 0.15 12.0 1.5 2.3 1 1 1 2 2 2 0 NleF caspase inhibitor SLX9 PF15341.6 VDK83124.1 - 0.13 12.7 7.1 0.19 12.1 7.1 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Uso1_p115_C PF04871.13 VDK83124.1 - 0.13 12.6 8.6 0.045 14.1 5.1 1.9 1 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region UPF0242 PF06785.11 VDK83124.1 - 0.13 12.3 20.6 0.93 9.6 7.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 VDK83124.1 - 0.14 12.5 11.2 1.9 8.9 1.4 3.3 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 VDK83124.1 - 0.27 11.7 14.3 1.2 9.7 3.1 3.2 2 1 1 3 3 3 0 Cell division protein ZapB DUF848 PF05852.11 VDK83124.1 - 0.45 10.6 12.8 0.4 10.8 3.9 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) LPP PF04728.13 VDK83124.1 - 0.56 10.6 6.1 2 8.9 0.8 3.1 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Swi5 PF07061.11 VDK83124.1 - 0.97 9.6 12.6 1.4 9.0 2.6 3.0 2 1 0 2 2 2 0 Swi5 HMMR_C PF15908.5 VDK83124.1 - 1.1 9.5 11.3 0.069 13.4 3.3 2.2 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal TSC22 PF01166.18 VDK83124.1 - 1.1 9.6 10.6 0.98 9.8 1.9 3.3 2 2 1 3 3 3 0 TSC-22/dip/bun family Fib_alpha PF08702.10 VDK83124.1 - 1.4 9.1 15.2 0.28 11.3 3.8 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4140 PF13600.6 VDK83124.1 - 1.7 9.2 8.4 3.4 8.2 0.2 2.8 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4200 PF13863.6 VDK83124.1 - 1.8 8.9 22.1 0.14 12.5 7.1 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) SlyX PF04102.12 VDK83124.1 - 2 9.1 11.6 10 6.8 0.9 2.7 2 1 0 2 2 2 0 SlyX DUF1043 PF06295.12 VDK83124.1 - 5.7 7.0 10.8 0.55 10.2 3.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Atg14 PF10186.9 VDK83124.1 - 7 5.6 18.9 5.1 6.1 4.7 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HIP1_clath_bdg PF16515.5 VDK83124.1 - 7.3 7.3 17.0 2.1 9.0 3.0 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Csm1_N PF18504.1 VDK83124.1 - 8.9 6.7 14.7 2 8.8 0.7 3.2 2 1 1 3 3 3 0 Csm1 N-terminal domain Exonuc_VII_L PF02601.15 VDK83124.1 - 9.6 5.7 11.5 15 5.0 11.5 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit TIR_3 PF18567.1 VDK83125.1 - 0.091 12.8 1.7 0.81 9.7 1.5 2.1 1 1 1 2 2 2 0 Toll/interleukin-1 receptor domain Peptidase_C1 PF00112.23 VDK83127.1 - 4.9e-75 252.4 0.8 2.4e-74 250.1 0.1 2.0 2 0 0 2 2 2 1 Papain family cysteine protease Cystatin PF00031.21 VDK83127.1 - 2.5e-11 43.7 0.1 5.9e-11 42.5 0.1 1.7 1 0 0 1 1 1 1 Cystatin domain Inhibitor_I29 PF08246.12 VDK83127.1 - 6e-10 39.4 0.7 1.5e-09 38.2 0.7 1.7 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 VDK83127.1 - 0.0014 17.5 1.1 0.026 13.3 0.1 2.2 2 0 0 2 2 2 1 Peptidase C1-like family SQAPI PF16845.5 VDK83127.1 - 0.09 13.1 0.7 0.17 12.2 0.1 1.8 2 0 0 2 2 2 0 Aspartic acid proteinase inhibitor DUF3685 PF12452.8 VDK83127.1 - 0.16 11.7 1.3 0.24 11.1 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) Kazal_2 PF07648.15 VDK83128.1 - 1.9e-51 172.0 89.7 1.4e-09 37.9 3.9 10.4 9 1 1 10 10 10 9 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 VDK83128.1 - 5.7e-41 138.3 97.1 9.9e-07 28.7 4.0 11.0 10 1 0 10 10 10 10 Kazal-type serine protease inhibitor domain Mito_carr PF00153.27 VDK83129.1 - 3.7e-55 183.8 3.2 4.2e-18 65.1 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Peptidase_C97 PF05903.14 VDK83130.1 - 1.3e-30 106.2 0.0 2e-30 105.6 0.0 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 VDK83130.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Lecithin retinol acyltransferase MCM PF00493.23 VDK83146.1 - 1.2e-93 312.4 0.0 3e-93 311.0 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 VDK83146.1 - 3.1e-39 133.7 0.3 6.3e-39 132.7 0.3 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 VDK83146.1 - 4.9e-24 84.6 0.1 1.3e-23 83.2 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 VDK83146.1 - 1.8e-12 47.8 3.2 9e-12 45.5 1.7 2.9 2 1 1 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 VDK83146.1 - 1.7e-09 37.4 0.4 3.4e-06 26.6 0.0 2.7 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 VDK83146.1 - 5.5e-09 36.1 0.0 1.8e-08 34.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 VDK83146.1 - 1.3e-05 25.1 0.1 4.4e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Elf1 PF05129.13 VDK83146.1 - 0.00081 19.4 0.7 0.0043 17.1 0.3 2.1 2 0 0 2 2 2 1 Transcription elongation factor Elf1 like Sigma54_activat PF00158.26 VDK83146.1 - 0.0047 16.7 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain Med31 PF05669.12 VDK83146.1 - 0.0073 16.3 2.0 0.036 14.1 1.7 2.1 2 0 0 2 2 2 1 SOH1 AAA PF00004.29 VDK83146.1 - 0.1 13.0 0.0 0.42 11.0 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) EF-hand_1 PF00036.32 VDK83148.1 - 1.1e-25 87.2 15.6 9.3e-05 21.7 0.1 6.5 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 VDK83148.1 - 2.8e-24 85.3 19.8 9.5e-09 35.6 1.7 3.7 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_8 PF13833.6 VDK83148.1 - 1.3e-19 69.7 9.5 0.00015 21.5 0.1 5.4 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_6 PF13405.6 VDK83148.1 - 1.2e-18 65.4 14.8 0.00086 19.1 0.1 6.6 6 0 0 6 6 6 6 EF-hand domain EF-hand_5 PF13202.6 VDK83148.1 - 2.5e-17 61.5 17.6 0.0004 19.7 0.1 6.6 6 0 0 6 6 6 4 EF hand SPARC_Ca_bdg PF10591.9 VDK83148.1 - 1.3e-06 28.7 11.0 0.0098 16.2 1.3 3.5 3 1 0 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 VDK83148.1 - 0.00014 21.7 5.8 4.5 7.2 0.1 4.8 5 0 0 5 5 5 3 EF hand DUF1636 PF07845.11 VDK83148.1 - 0.12 12.8 0.0 0.68 10.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1636) HECT PF00632.25 VDK83149.1 - 3.5e-100 335.5 0.0 5.2e-100 334.9 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 VDK83149.1 - 3.1e-35 119.9 4.1 8.2e-13 48.2 0.1 3.9 3 0 0 3 3 3 3 WW domain C2 PF00168.30 VDK83149.1 - 4.1e-16 59.1 0.1 7.4e-15 55.1 0.1 2.4 1 1 0 1 1 1 1 C2 domain ThuA PF06283.11 VDK83149.1 - 0.14 12.4 0.4 15 5.7 0.1 2.4 2 0 0 2 2 2 0 Trehalose utilisation adh_short PF00106.25 VDK83150.1 - 4.3e-21 75.3 0.1 1.3e-18 67.2 0.1 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK83150.1 - 3.2e-09 36.7 0.0 1.3e-08 34.8 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 VDK83150.1 - 3.4e-07 30.0 0.1 5.5e-07 29.3 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 VDK83150.1 - 1.3e-05 24.9 0.0 2.5e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 VDK83150.1 - 2.1e-05 24.5 0.0 3.8e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 VDK83150.1 - 0.0007 19.1 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 VDK83150.1 - 0.0011 18.9 0.0 0.0027 17.7 0.0 1.6 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 VDK83150.1 - 0.011 14.8 0.0 0.018 14.2 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 VDK83150.1 - 0.033 13.3 0.0 0.065 12.4 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 VDK83150.1 - 0.037 13.2 0.0 0.067 12.3 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein Semialdhyde_dh PF01118.24 VDK83150.1 - 0.06 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain GD_AH_C PF04295.13 VDK83150.1 - 0.096 11.5 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 D-galactarate dehydratase / Altronate hydrolase, C terminus DapB_N PF01113.20 VDK83150.1 - 0.12 12.5 0.0 0.53 10.4 0.0 2.1 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Ints3 PF10189.9 VDK83152.1 - 1.2e-39 135.9 0.2 7.8e-39 133.3 0.2 2.4 1 1 0 1 1 1 1 Integrator complex subunit 3 EST1_DNA_bind PF10373.9 VDK83153.1 - 0.00044 19.8 1.4 0.0012 18.4 0.3 2.0 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain Moulting_cycle PF04870.16 VDK83160.1 - 2.2e-66 224.5 4.5 2.2e-66 224.5 4.5 3.7 3 1 1 4 4 4 2 Moulting cycle DUF4201 PF13870.6 VDK83160.1 - 0.0043 16.8 3.1 0.0043 16.8 3.1 3.3 4 0 0 4 4 4 1 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 VDK83160.1 - 7.5 6.6 13.5 0.062 13.4 2.4 2.7 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Eapp_C PF10238.9 VDK83161.1 - 4.3e-39 134.0 2.5 4.3e-39 134.0 2.5 2.6 4 0 0 4 4 4 1 E2F-associated phosphoprotein SAM_4 PF18017.1 VDK83161.1 - 5.2e-16 58.4 0.1 2.9e-15 56.0 0.1 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF5577 PF17740.1 VDK83161.1 - 3.2e-05 23.8 0.2 0.0001 22.1 0.2 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5577) SAM_1 PF00536.30 VDK83161.1 - 4.7e-05 23.7 0.0 0.00013 22.3 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK83161.1 - 0.067 13.3 0.1 0.18 11.9 0.1 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) 7TM_GPCR_Srbc PF10316.9 VDK83162.1 - 1.6e-18 67.2 11.0 3.5e-18 66.1 11.0 1.6 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srsx PF10320.9 VDK83162.1 - 2.1e-10 40.4 11.2 3.3e-10 39.8 11.2 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_1 PF00001.21 VDK83162.1 - 5.1e-10 39.1 6.4 7.4e-10 38.6 6.4 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 VDK83162.1 - 5.4e-05 23.0 11.3 0.00015 21.5 11.3 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx LPG_synthase_TM PF03706.13 VDK83163.1 - 0.0014 18.3 1.1 0.0016 18.0 1.1 1.1 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region TMEM154 PF15102.6 VDK83163.1 - 0.14 12.0 3.2 0.11 12.4 1.1 1.8 1 1 1 2 2 2 0 TMEM154 protein family Y_phosphatase PF00102.27 VDK83171.1 - 2.2e-74 250.0 0.9 2.8e-74 249.6 0.9 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 VDK83171.1 - 0.004 17.1 0.2 0.013 15.5 0.2 2.0 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 VDK83171.1 - 0.0081 16.3 0.5 0.043 13.9 0.3 2.2 2 0 0 2 2 2 1 Inositol hexakisphosphate DSPc PF00782.20 VDK83171.1 - 0.015 15.1 0.0 0.049 13.4 0.0 1.9 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain TAF PF02969.17 VDK83173.1 - 0.0016 18.6 0.1 0.0029 17.7 0.1 1.4 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Ribosomal_L7Ae PF01248.26 VDK83175.1 - 2.1e-24 85.0 0.6 3.5e-24 84.4 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family MFS_1 PF07690.16 VDK83176.1 - 6.6e-11 41.7 47.2 8e-08 31.6 15.5 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily Glycophorin_A PF01102.18 VDK83176.1 - 0.024 14.9 0.1 0.1 12.9 0.1 2.1 1 0 0 1 1 1 0 Glycophorin A Arm PF00514.23 VDK83177.1 - 1.4e-14 53.5 4.6 0.014 15.5 0.0 7.1 7 0 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT PF02985.22 VDK83177.1 - 0.0075 16.4 0.1 0.33 11.3 0.0 3.2 2 0 0 2 2 2 1 HEAT repeat HEAT_2 PF13646.6 VDK83177.1 - 0.013 15.9 1.4 0.089 13.2 0.1 2.9 3 0 0 3 3 3 0 HEAT repeats Adaptin_N PF01602.20 VDK83177.1 - 0.028 13.0 3.1 0.21 10.1 3.1 2.2 1 1 0 1 1 1 0 Adaptin N terminal region DUF3636 PF12331.8 VDK83177.1 - 0.095 12.5 2.5 0.32 10.8 2.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) SRR1 PF07985.12 VDK83189.1 - 2.3e-06 27.5 0.0 5.1e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 SRR1 MADF_DNA_bdg PF10545.9 VDK83191.1 - 4.5e-16 58.9 1.2 1e-15 57.8 1.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like BESS PF02944.20 VDK83191.1 - 0.00016 21.4 0.2 0.00036 20.3 0.0 1.7 2 0 0 2 2 2 1 BESS motif Myb_DNA-bind_4 PF13837.6 VDK83191.1 - 0.2 12.1 0.9 0.43 11.0 0.4 1.8 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain dNK PF01712.19 VDK83192.1 - 3.3e-41 141.4 0.8 5.2e-41 140.8 0.8 1.3 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 VDK83192.1 - 0.0094 15.6 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Thymidylate kinase SKI PF01202.22 VDK83192.1 - 0.064 13.4 0.6 24 5.0 0.0 3.0 2 1 1 3 3 3 0 Shikimate kinase Cytidylate_kin2 PF13189.6 VDK83192.1 - 0.07 13.3 0.0 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase-like family DUF2070 PF09843.9 VDK83192.1 - 0.36 9.1 6.9 0.52 8.5 6.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Bromodomain PF00439.25 VDK83196.1 - 1.6e-21 76.1 0.1 4.1e-21 74.8 0.1 1.7 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 VDK83196.1 - 9.2e-18 63.9 20.4 2.2e-11 43.5 5.5 3.0 3 0 0 3 3 3 2 PHD-finger MBD PF01429.19 VDK83196.1 - 2.4e-13 49.6 0.0 5.7e-13 48.4 0.0 1.7 1 0 0 1 1 1 1 Methyl-CpG binding domain WSD PF15613.6 VDK83196.1 - 1.6e-08 34.9 0.1 1.1e-07 32.3 0.0 2.5 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif PHD_2 PF13831.6 VDK83196.1 - 1.2e-06 28.0 15.5 0.00085 18.8 1.3 3.5 3 0 0 3 3 3 2 PHD-finger DDT PF02791.17 VDK83196.1 - 0.0009 19.5 0.6 0.0028 17.9 0.6 1.9 1 0 0 1 1 1 1 DDT domain Prok-RING_1 PF14446.6 VDK83196.1 - 0.029 14.3 16.7 0.14 12.1 0.9 3.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 MADF_DNA_bdg PF10545.9 VDK83196.1 - 0.067 13.5 1.9 0.091 13.1 0.1 2.2 2 0 0 2 2 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like PHD_4 PF16866.5 VDK83196.1 - 0.078 13.1 17.6 0.029 14.5 4.4 3.1 2 0 0 2 2 2 0 PHD-finger C1_1 PF00130.22 VDK83196.1 - 0.14 12.1 14.7 0.093 12.6 1.7 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 VDK83196.1 - 0.22 11.1 14.5 0.12 11.9 1.8 4.0 4 0 0 4 4 4 0 PHD/FYVE-zinc-finger like domain Zf_RING PF16744.5 VDK83196.1 - 0.49 10.5 13.0 0.4 10.8 0.7 3.4 3 0 0 3 3 2 0 KIAA1045 RING finger zf-RING_9 PF13901.6 VDK83196.1 - 7.3 6.5 19.1 2.3 8.2 6.7 3.2 2 1 1 3 3 3 0 Putative zinc-RING and/or ribbon BAR_3_WASP_bdg PF10456.9 VDK83202.1 - 1.6e-72 243.8 1.0 2.7e-72 243.0 1.0 1.4 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein PX PF00787.24 VDK83202.1 - 8.3e-21 74.1 0.1 2.1e-20 72.8 0.1 1.7 1 0 0 1 1 1 1 PX domain SH3_9 PF14604.6 VDK83202.1 - 8.8e-12 44.7 0.0 2e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK83202.1 - 9.3e-09 34.8 0.0 2.7e-08 33.3 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK83202.1 - 4.4e-08 32.7 0.1 1e-07 31.5 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain Syntaxin-18_N PF10496.9 VDK83202.1 - 0.14 12.5 0.3 0.43 10.9 0.3 1.9 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus Vps5 PF09325.10 VDK83202.1 - 0.73 9.3 5.1 5.5 6.5 0.2 3.4 2 1 1 3 3 3 0 Vps5 C terminal like PDZ PF00595.24 VDK83204.1 - 5.1e-39 132.5 8.4 1.3e-12 47.9 0.1 3.8 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 VDK83204.1 - 6.6e-23 80.3 2.3 5.7e-07 29.3 0.1 4.4 4 0 0 4 4 4 3 PDZ domain FERM_M PF00373.18 VDK83204.1 - 1e-21 77.5 0.6 5.2e-21 75.2 0.0 2.3 2 0 0 2 2 2 1 FERM central domain PDZ_2 PF13180.6 VDK83204.1 - 1.8e-11 44.2 8.0 0.016 15.6 0.2 5.3 5 0 0 5 5 5 3 PDZ domain FERM_C PF09380.10 VDK83204.1 - 1.7e-10 41.1 0.4 3.9e-10 40.0 0.4 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 VDK83204.1 - 2.3e-08 33.9 0.0 4.9e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 FERM N-terminal domain Ribosomal_S13_N PF08069.12 VDK83204.1 - 0.17 11.9 0.1 0.46 10.6 0.1 1.7 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Pkinase_Tyr PF07714.17 VDK83205.1 - 3.7e-83 278.8 0.0 4.9e-83 278.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK83205.1 - 2.3e-44 151.8 0.0 3.5e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PBD PF00786.28 VDK83205.1 - 0.0031 17.8 0.4 0.0082 16.5 0.1 1.9 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 VDK83205.1 - 0.011 15.1 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 VDK83205.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acyltransferase PF01553.21 VDK83206.1 - 2e-28 98.7 0.2 4.5e-28 97.5 0.1 1.6 2 0 0 2 2 2 1 Acyltransferase Pex2_Pex12 PF04757.14 VDK83207.1 - 1.4e-05 24.8 3.0 0.0036 16.9 3.0 2.9 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 VDK83207.1 - 0.023 14.6 8.7 0.076 12.9 6.6 2.7 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 VDK83207.1 - 0.49 10.2 12.6 0.22 11.3 9.7 2.1 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_5 PF14634.6 VDK83207.1 - 0.85 9.6 13.7 1.1 9.3 11.7 2.2 2 0 0 2 2 2 0 zinc-RING finger domain RRM_1 PF00076.22 VDK83208.1 - 2.7e-07 30.3 0.2 4.4e-07 29.6 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Helicase_C_3 PF13625.6 VDK83208.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.4 1 1 0 1 1 1 0 Helicase conserved C-terminal domain RRM_occluded PF16842.5 VDK83208.1 - 0.13 12.2 0.1 0.43 10.5 0.1 1.8 1 1 0 1 1 1 0 Occluded RNA-recognition motif WH1 PF00568.23 VDK83211.1 - 7.3e-24 83.8 0.0 1.1e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 VDK83211.1 - 1.1e-08 35.3 0.0 2.6e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain VHS PF00790.19 VDK83213.1 - 1.9e-41 141.2 0.1 1.9e-41 141.2 0.1 2.2 2 0 0 2 2 2 1 VHS domain Hrs_helical PF12210.8 VDK83213.1 - 1.4e-33 115.3 9.4 1.4e-33 115.3 9.4 3.7 2 1 1 3 3 3 1 Hepatocyte growth factor-regulated tyrosine kinase substrate FYVE PF01363.21 VDK83213.1 - 8.8e-18 64.2 8.4 2.7e-17 62.7 8.4 1.8 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 VDK83213.1 - 0.0036 17.5 5.5 0.0036 17.5 5.5 3.2 3 1 0 3 3 3 1 FYVE-type zinc finger PknG_rubred PF16919.5 VDK83213.1 - 1.1 9.4 6.1 0.3 11.2 0.8 2.9 2 0 0 2 2 2 0 Protein kinase G rubredoxin domain Anillin_N PF16018.5 VDK83213.1 - 1.8 9.2 7.6 3.7 8.2 2.9 3.5 2 0 0 2 2 2 0 Anillin N-terminus DZR PF12773.7 VDK83213.1 - 2.2 8.3 8.8 16 5.6 0.8 2.8 1 1 1 2 2 2 0 Double zinc ribbon Glyco_hydro_15 PF00723.21 VDK83214.1 - 2.2e-95 320.1 0.0 2.6e-95 319.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 TTR-52 PF01060.23 VDK83233.1 - 8e-22 77.7 0.0 1.8e-21 76.6 0.0 1.6 1 1 0 1 1 1 1 Transthyretin-like family TTR-52 PF01060.23 VDK83234.1 - 1.2e-14 54.7 0.0 1.6e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family MBF1 PF08523.10 VDK83235.1 - 7.5e-21 74.4 2.0 7.5e-21 74.4 2.0 1.9 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 VDK83235.1 - 6.8e-13 48.5 0.1 1.5e-12 47.3 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 VDK83235.1 - 1.5e-06 28.4 0.1 8.7e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 VDK83235.1 - 0.00016 21.6 0.1 0.00032 20.6 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain MMS1_N PF10433.9 VDK83236.1 - 9.9e-77 258.6 0.0 2.6e-76 257.2 0.0 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 VDK83236.1 - 5.9e-74 249.3 1.8 1.2e-73 248.2 0.4 2.2 3 0 0 3 3 3 1 CPSF A subunit region VWA_N PF08399.11 VDK83237.1 - 1.1e-27 96.9 0.1 5e-27 94.8 0.0 2.2 2 0 0 2 2 2 1 VWA N-terminal dCache_1 PF02743.18 VDK83237.1 - 3.2e-14 53.3 0.4 4.5e-09 36.5 0.1 2.6 2 0 0 2 2 2 2 Cache domain VWA_2 PF13519.6 VDK83237.1 - 7e-08 33.1 0.0 2.2e-07 31.5 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 VDK83237.1 - 1.8e-07 31.6 0.1 5.7e-07 29.9 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 VDK83237.1 - 1.2e-05 25.3 0.0 6e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VGCC_alpha2 PF08473.11 VDK83237.1 - 0.0023 16.8 15.1 0.0039 16.0 1.8 4.4 3 1 0 4 4 4 2 Neuronal voltage-dependent calcium channel alpha 2acd dCache_1 PF02743.18 VDK83242.1 - 1.1e-07 31.9 0.0 0.0089 15.8 0.0 2.5 2 0 0 2 2 2 2 Cache domain Pkinase_Tyr PF07714.17 VDK83244.1 - 2.4e-92 308.9 0.0 3.8e-92 308.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK83244.1 - 5.9e-47 160.2 0.0 1.1e-46 159.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain EphA2_TM PF14575.6 VDK83244.1 - 1.3e-15 58.1 0.0 2.5e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain fn3 PF00041.21 VDK83244.1 - 2.6e-09 37.3 0.8 6.1e-07 29.7 0.1 3.6 3 0 0 3 3 3 1 Fibronectin type III domain Ephrin_rec_like PF07699.13 VDK83244.1 - 0.00013 21.6 2.0 0.00013 21.6 2.0 3.3 2 1 1 3 3 3 1 Putative ephrin-receptor like Interfer-bind PF09294.10 VDK83244.1 - 0.036 14.4 0.2 0.43 10.9 0.0 2.4 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III SAM_2 PF07647.17 VDK83244.1 - 0.092 12.9 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF4945 PF16303.5 VDK83244.1 - 0.098 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4945) SAM_1 PF00536.30 VDK83244.1 - 0.17 12.4 0.0 0.32 11.5 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ephrin_lbd PF01404.19 VDK83245.1 - 1.9e-39 135.6 0.9 2.5e-39 135.2 0.9 1.1 1 0 0 1 1 1 1 Ephrin receptor ligand binding domain Tox-HDC PF15656.6 VDK83245.1 - 0.005 17.0 0.1 0.0082 16.3 0.1 1.3 1 0 0 1 1 1 1 Toxin with a H, D/N and C signature Sushi PF00084.20 VDK83245.1 - 0.32 11.6 0.1 0.32 11.6 0.1 2.7 3 0 0 3 3 3 0 Sushi repeat (SCR repeat) Plasmod_Pvs28 PF06247.11 VDK83245.1 - 0.41 11.0 7.3 0.28 11.5 4.5 2.3 2 1 0 2 2 2 0 Pvs28 EGF domain Myelin_PLP PF01275.19 VDK83253.1 - 6.1e-12 45.9 9.1 7.8e-12 45.6 9.1 1.1 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) UCH PF00443.29 VDK83254.1 - 3.8e-47 160.9 0.6 3.8e-47 160.9 0.6 3.4 4 1 1 5 5 5 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK83254.1 - 4.1e-24 85.7 0.0 3.5e-23 82.7 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Thioredoxin_11 PF18078.1 VDK83263.1 - 0.12 12.5 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin-like SNTX domain Motile_Sperm PF00635.26 VDK83264.1 - 1.3e-05 25.0 0.0 0.00017 21.4 0.0 2.2 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Ibs_toxin PF13956.6 VDK83264.1 - 0.65 10.1 7.3 1.5 8.9 7.3 1.6 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system Carn_acyltransf PF00755.20 VDK83269.1 - 1.3e-180 601.9 0.0 1.5e-180 601.7 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CPT_N PF16484.5 VDK83269.1 - 2e-19 69.3 0.2 4.3e-19 68.2 0.2 1.6 1 0 0 1 1 1 1 Carnitine O-palmitoyltransferase N-terminus 2OG-FeII_Oxy_2 PF13532.6 VDK83272.1 - 5.3e-10 39.8 0.8 1.2e-07 32.1 0.0 2.1 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily DUF1798 PF08807.10 VDK83272.1 - 0.043 14.0 0.1 0.97 9.6 0.0 2.4 2 1 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) DnaB PF00772.21 VDK83272.1 - 0.12 12.5 0.2 0.49 10.5 0.0 2.0 3 0 0 3 3 3 0 DnaB-like helicase N terminal domain Snf7 PF03357.21 VDK83274.1 - 2.7e-41 141.1 30.4 2.7e-41 141.1 30.4 1.4 2 0 0 2 2 2 1 Snf7 Peptidase_M57 PF12388.8 VDK83274.1 - 0.059 13.0 1.4 0.088 12.4 1.0 1.6 1 1 1 2 2 2 0 Dual-action HEIGH metallo-peptidase Robl_LC7 PF03259.17 VDK83274.1 - 0.074 12.8 0.2 0.23 11.3 0.1 1.9 2 0 0 2 2 2 0 Roadblock/LC7 domain Chitin_synth_2 PF03142.15 VDK83276.1 - 1.6e-24 86.5 2.8 1.6e-24 86.5 2.8 2.3 2 0 0 2 2 2 1 Chitin synthase PAP2_C PF14360.6 VDK83276.1 - 1.6e-19 70.2 12.6 1.6e-19 70.2 12.6 4.9 6 0 0 6 6 6 1 PAP2 superfamily C-terminal Glyco_trans_2_3 PF13632.6 VDK83276.1 - 1.4e-11 44.7 1.4 1.4e-11 44.7 1.4 2.6 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 VDK83276.1 - 0.00081 19.3 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 VDK83276.1 - 0.049 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF5337 PF17272.2 VDK83276.1 - 2.8 7.8 4.9 0.5 10.2 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5337) Pkinase PF00069.25 VDK83282.1 - 1.7e-50 171.9 0.2 4.7e-37 127.8 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK83282.1 - 4.6e-25 88.4 0.0 2.3e-19 69.7 0.2 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase PQQ PF01011.21 VDK83282.1 - 1.2e-05 25.0 0.0 0.17 11.9 0.0 3.5 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_2 PF13360.6 VDK83282.1 - 1.7e-05 24.6 0.0 0.00019 21.1 0.0 2.4 1 1 0 1 1 1 1 PQQ-like domain PQQ_3 PF13570.6 VDK83282.1 - 0.0033 17.9 0.0 0.44 11.1 0.0 3.9 4 0 0 4 4 4 1 PQQ-like domain Kinase-like PF14531.6 VDK83282.1 - 0.03 13.6 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 VDK83282.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family MFS_1 PF07690.16 VDK83285.1 - 1.8e-33 115.9 35.6 1.1e-24 87.1 7.5 2.5 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_4 PF06779.14 VDK83285.1 - 3.4e-11 43.1 19.3 1.4e-08 34.5 9.1 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 VDK83285.1 - 9.3e-08 31.3 5.8 0.003 16.5 11.0 2.7 1 1 1 2 2 2 2 MFS_1 like family DMP1 PF07263.11 VDK83285.1 - 0.097 11.5 14.8 0.17 10.7 14.8 1.3 1 0 0 1 1 1 0 Dentin matrix protein 1 (DMP1) Ldl_recept_a PF00057.18 VDK83287.1 - 1.9e-52 175.2 133.8 7.4e-10 38.9 10.0 10.5 9 1 1 10 10 10 8 Low-density lipoprotein receptor domain class A PRKCSH-like PF12999.7 VDK83287.1 - 2.1e-05 24.4 44.5 5.6e-05 23.0 14.8 5.6 1 1 4 5 5 5 2 Glucosidase II beta subunit-like Smoa_sbd PF17885.1 VDK83287.1 - 0.0006 19.9 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 Styrene monooxygenase A putative substrate binding domain MPS2 PF17060.5 VDK83287.1 - 0.28 10.4 0.3 0.4 9.9 0.3 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 MAM PF00629.23 VDK83290.1 - 1.2e-13 51.3 0.0 3.6e-08 33.5 0.0 2.7 2 1 0 2 2 2 2 MAM domain, meprin/A5/mu EGF_CA PF07645.15 VDK83294.1 - 1.3e-13 50.9 27.1 3.9e-06 27.0 6.6 9.5 7 1 2 9 9 9 4 Calcium-binding EGF domain Ldl_recept_a PF00057.18 VDK83294.1 - 2e-13 50.3 38.7 2.8e-05 24.2 5.2 9.2 6 1 3 9 9 9 4 Low-density lipoprotein receptor domain class A EGF_3 PF12947.7 VDK83294.1 - 2.1e-08 34.2 25.7 0.00022 21.3 5.0 8.7 7 1 1 8 8 8 4 EGF domain EGF PF00008.27 VDK83294.1 - 1.2e-06 28.7 11.4 2.3e-05 24.6 3.8 9.5 10 0 0 10 10 10 5 EGF-like domain EGF_MSP1_1 PF12946.7 VDK83294.1 - 2.4e-05 24.3 11.7 0.00035 20.6 2.6 7.4 7 0 0 7 7 7 3 MSP1 EGF domain 1 hEGF PF12661.7 VDK83294.1 - 0.0052 17.4 70.6 0.0064 17.1 2.5 10.3 10 1 0 10 10 10 4 Human growth factor-like EGF EGF_CA PF07645.15 VDK83295.1 - 1.2e-133 435.1 569.4 1.8e-07 31.2 4.1 46.2 45 1 1 46 46 46 36 Calcium-binding EGF domain EGF_3 PF12947.7 VDK83295.1 - 6.3e-102 333.5 556.8 1.1e-06 28.8 4.2 46.5 46 1 1 47 47 47 35 EGF domain EGF PF00008.27 VDK83295.1 - 9.5e-97 316.7 502.0 7.9e-06 26.1 2.8 45.9 45 0 0 45 45 45 38 EGF-like domain hEGF PF12661.7 VDK83295.1 - 5.5e-85 277.4 430.0 2.4e-05 24.8 3.4 47.3 46 1 0 46 46 46 35 Human growth factor-like EGF VWA PF00092.28 VDK83295.1 - 1.9e-41 142.2 0.1 3.1e-41 141.5 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain FXa_inhibition PF14670.6 VDK83295.1 - 5.5e-14 52.2 527.6 0.0019 18.4 5.1 45.6 45 0 0 45 45 45 34 Coagulation Factor Xa inhibitory site VWA_2 PF13519.6 VDK83295.1 - 5.7e-14 52.7 0.0 1e-13 51.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain cEGF PF12662.7 VDK83295.1 - 4.5e-11 42.5 343.4 0.0059 16.5 0.2 42.8 44 1 0 44 44 44 24 Complement Clr-like EGF-like SEA PF01390.20 VDK83295.1 - 3.2e-05 23.9 0.0 0.2 11.7 0.0 2.5 2 0 0 2 2 2 2 SEA domain Plasmod_Pvs28 PF06247.11 VDK83295.1 - 0.00071 19.8 6.7 0.00071 19.8 6.7 44.7 46 0 0 46 46 46 24 Pvs28 EGF domain DUF4777 PF16007.5 VDK83296.1 - 0.077 13.3 0.0 12 6.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4777) Paf67 PF10255.9 VDK83300.1 - 8.2e-139 463.1 1.4 1.1e-138 462.7 1.4 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 PCI PF01399.27 VDK83300.1 - 0.056 14.0 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 PCI domain DUF368 PF04018.13 VDK83300.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF368) DEP PF00610.21 VDK83302.1 - 5.5e-10 39.2 0.8 1.4e-09 37.8 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF148 PF02520.17 VDK83302.1 - 0.25 11.5 4.0 0.3 11.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF148 Tubulin PF00091.25 VDK83303.1 - 6.7e-65 219.0 0.0 1.3e-64 218.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK83303.1 - 4.8e-43 146.3 0.1 8.1e-43 145.6 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 VDK83303.1 - 1.6e-05 25.2 0.1 4.4e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 VDK83303.1 - 0.021 14.5 0.0 0.044 13.5 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain TrmK PF04816.12 VDK83303.1 - 0.052 13.1 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase Pkinase PF00069.25 VDK83304.1 - 4.1e-40 137.8 0.0 6.4e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ribonuc_2-5A PF06479.12 VDK83304.1 - 1.4e-38 131.9 2.5 1.6e-38 131.7 1.0 1.9 2 0 0 2 2 2 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 VDK83304.1 - 4.8e-26 91.6 0.0 8.8e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK83304.1 - 9.2e-07 28.0 0.0 0.00023 20.1 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase Kdo PF06293.14 VDK83304.1 - 0.0065 15.8 0.0 0.017 14.5 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ASC PF00858.24 VDK83305.1 - 3.5e-114 382.2 15.3 4.8e-114 381.7 15.3 1.2 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Saf_2TM PF18303.1 VDK83305.1 - 0.027 14.0 0.1 0.06 12.9 0.1 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain PQQ_2 PF13360.6 VDK83306.1 - 1.3e-08 34.8 0.0 0.00019 21.1 0.0 2.6 1 1 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 VDK83306.1 - 2.3e-08 33.6 0.4 0.0023 17.8 0.0 3.2 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_3 PF13570.6 VDK83306.1 - 0.0035 17.8 0.9 3.2 8.4 0.0 4.4 5 0 0 5 5 5 1 PQQ-like domain RRM_7 PF16367.5 VDK83309.1 - 1.9e-36 124.0 0.0 3.6e-33 113.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif CEBP_ZZ PF16366.5 VDK83309.1 - 1e-18 67.3 8.8 2.7e-18 66.0 8.8 1.8 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 VDK83309.1 - 5.2e-09 35.8 0.0 2.1e-05 24.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.29 VDK83316.1 - 5.4e-91 301.9 0.0 3.8e-46 156.8 0.0 3.5 2 1 1 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK83316.1 - 1.1e-26 92.4 3.6 4.6e-13 48.7 0.6 3.0 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 VDK83316.1 - 2.1e-21 75.9 1.4 5e-21 74.7 1.4 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_16 PF13191.6 VDK83316.1 - 5.6e-14 52.9 0.0 1.5e-05 25.5 0.0 3.7 2 2 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.12 VDK83316.1 - 3.2e-13 49.7 0.0 2.7e-05 24.0 0.0 3.1 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain CDC48_2 PF02933.17 VDK83316.1 - 2.4e-11 43.3 0.0 5.2e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_5 PF07728.14 VDK83316.1 - 6.6e-11 42.4 0.1 9.1e-05 22.5 0.0 3.6 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 VDK83316.1 - 6.2e-10 39.4 0.0 0.00017 21.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 VDK83316.1 - 1e-09 38.8 0.1 0.0064 16.8 0.0 3.8 2 2 1 3 3 3 2 AAA domain AAA_2 PF07724.14 VDK83316.1 - 6.6e-09 36.1 0.0 0.00056 20.1 0.0 3.3 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 VDK83316.1 - 9.2e-09 35.0 0.0 0.002 17.4 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 VDK83316.1 - 1.3e-08 35.5 0.0 0.005 17.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 VDK83316.1 - 1.8e-07 31.1 0.3 9.5e-06 25.5 0.1 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 VDK83316.1 - 3.3e-07 30.6 0.0 0.0083 16.5 0.0 3.0 3 0 0 3 3 2 2 RNA helicase IstB_IS21 PF01695.17 VDK83316.1 - 3.7e-07 30.0 0.0 0.033 13.9 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 VDK83316.1 - 3.9e-07 29.7 0.1 0.027 13.9 0.0 2.8 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 VDK83316.1 - 1.4e-06 28.6 0.3 0.043 14.1 0.0 3.2 3 1 1 4 4 3 2 AAA domain Parvo_NS1 PF01057.17 VDK83316.1 - 1.7e-06 27.4 0.1 0.019 14.1 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 VDK83316.1 - 3.4e-06 26.8 0.1 0.33 10.5 0.0 3.5 2 1 1 3 3 3 2 AAA domain ABC_tran PF00005.27 VDK83316.1 - 3.9e-06 27.4 0.0 0.005 17.4 0.0 3.4 2 1 0 2 2 2 1 ABC transporter ATPase PF06745.13 VDK83316.1 - 6.1e-06 25.8 0.0 0.43 9.9 0.0 3.4 3 0 0 3 3 3 2 KaiC NACHT PF05729.12 VDK83316.1 - 9.8e-06 25.6 0.1 0.033 14.1 0.0 3.3 3 0 0 3 3 3 1 NACHT domain UFD1 PF03152.14 VDK83316.1 - 1.6e-05 24.5 0.0 3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 AAA_7 PF12775.7 VDK83316.1 - 3e-05 23.6 0.0 0.23 11.0 0.0 2.9 3 0 0 3 3 2 2 P-loop containing dynein motor region ATPase_2 PF01637.18 VDK83316.1 - 4.3e-05 23.5 0.0 0.23 11.3 0.0 3.5 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 VDK83316.1 - 6.8e-05 22.7 0.0 0.13 11.9 0.0 2.6 2 1 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 VDK83316.1 - 9e-05 22.4 0.0 0.36 10.6 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein TsaE PF02367.17 VDK83316.1 - 9.1e-05 22.5 0.0 0.34 10.9 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 VDK83316.1 - 0.00013 22.0 0.0 0.3 11.1 0.0 3.4 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 VDK83316.1 - 0.00014 22.3 0.2 0.92 9.9 0.0 3.3 4 0 0 4 4 2 2 AAA domain Sigma54_activat PF00158.26 VDK83316.1 - 0.00017 21.4 0.0 0.62 9.7 0.0 3.0 2 1 0 2 2 2 2 Sigma-54 interaction domain NB-ARC PF00931.22 VDK83316.1 - 0.00045 19.5 0.1 0.33 10.1 0.0 2.7 3 0 0 3 3 2 1 NB-ARC domain PhoH PF02562.16 VDK83316.1 - 0.00085 18.8 0.1 1.5 8.2 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein Zeta_toxin PF06414.12 VDK83316.1 - 0.0011 18.4 0.0 0.76 9.0 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin Sigma54_activ_2 PF14532.6 VDK83316.1 - 0.0012 19.0 0.0 0.92 9.6 0.0 3.1 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF815 PF05673.13 VDK83316.1 - 0.0013 18.0 0.0 1.2 8.3 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) DUF2075 PF09848.9 VDK83316.1 - 0.0016 17.8 0.0 0.55 9.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 VDK83316.1 - 0.0017 18.4 0.0 0.22 11.5 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_3 PF07726.11 VDK83316.1 - 0.0017 18.2 0.0 2.1 8.2 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 VDK83316.1 - 0.0029 17.4 0.2 2.4 7.9 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 VDK83316.1 - 0.004 17.5 0.5 3.6 7.9 0.2 3.2 3 1 0 3 3 2 0 AAA domain Cytidylate_kin2 PF13189.6 VDK83316.1 - 0.0043 17.2 0.0 2.4 8.2 0.0 2.7 2 0 0 2 2 2 1 Cytidylate kinase-like family Rad17 PF03215.15 VDK83316.1 - 0.0055 16.6 0.0 0.63 9.9 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 VDK83316.1 - 0.0065 16.2 0.0 0.19 11.4 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 VDK83316.1 - 0.028 14.1 0.1 3.3 7.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 VDK83316.1 - 0.04 13.8 0.2 9.2 6.1 0.0 3.5 4 1 0 4 4 2 0 NTPase KAP_NTPase PF07693.14 VDK83316.1 - 0.051 12.8 0.0 2.7 7.2 0.0 3.0 2 2 1 4 4 4 0 KAP family P-loop domain Cytidylate_kin PF02224.18 VDK83316.1 - 0.056 13.2 0.0 10 5.8 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase TniB PF05621.11 VDK83316.1 - 0.1 12.0 0.0 14 5.0 0.0 3.2 3 0 0 3 3 3 0 Bacterial TniB protein SKI PF01202.22 VDK83316.1 - 0.13 12.4 0.7 15 5.6 0.0 2.9 3 0 0 3 3 2 0 Shikimate kinase AAA_23 PF13476.6 VDK83316.1 - 0.17 12.4 0.2 22 5.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain Troponin PF00992.20 VDK83318.1 - 0.0077 16.5 10.1 0.0077 16.5 10.1 3.9 3 1 1 4 4 4 1 Troponin Y_phosphatase PF00102.27 VDK83326.1 - 7.6e-162 536.2 0.2 2.4e-84 282.6 0.0 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 VDK83326.1 - 2.5e-08 34.2 0.7 0.0038 17.2 0.1 3.1 3 0 0 3 3 3 2 Tyrosine phosphatase family PTPlike_phytase PF14566.6 VDK83326.1 - 3.9e-07 30.3 0.1 0.0099 16.0 0.0 3.4 4 0 0 4 4 4 2 Inositol hexakisphosphate DSPc PF00782.20 VDK83326.1 - 3.1e-06 27.0 0.0 0.072 12.9 0.0 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain DUF3827 PF12877.7 VDK83326.1 - 0.096 11.1 0.2 0.15 10.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Chromo PF00385.24 VDK83346.1 - 4.7e-12 45.6 0.1 1.1e-11 44.5 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mtf2_C PF14061.6 VDK83346.1 - 0.45 10.7 0.1 0.45 10.7 0.1 2.3 3 0 0 3 3 3 0 Polycomb-like MTF2 factor 2 PDZ PF00595.24 VDK83347.1 - 6.6e-13 48.8 0.1 5.8e-07 29.8 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDK83347.1 - 5.7e-11 42.6 0.2 8.5e-05 22.8 0.1 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK83347.1 - 1.2e-10 41.0 0.1 9.5e-06 25.4 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 VDK83347.1 - 0.00015 21.7 0.1 0.82 9.7 0.0 2.9 2 1 0 2 2 2 2 Tricorn protease PDZ domain HHH_9 PF17674.1 VDK83347.1 - 0.087 13.7 0.1 0.64 11.0 0.0 2.5 3 1 0 3 3 3 0 HHH domain Ribosomal_L16 PF00252.18 VDK83348.1 - 9.2e-42 142.2 0.1 1.3e-41 141.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Pkinase PF00069.25 VDK83349.1 - 1.3e-27 96.8 0.0 2.2e-27 96.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK83349.1 - 2.3e-12 46.7 0.0 3.9e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEPN_LA2681 PF18733.1 VDK83349.1 - 0.07 12.4 0.1 0.21 10.9 0.0 1.8 1 1 0 1 1 1 0 LA2681-like HEPN PDZ_6 PF17820.1 VDK83350.1 - 9.2e-05 22.2 0.0 0.013 15.3 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDK83350.1 - 0.0049 17.2 0.0 0.17 12.2 0.0 2.5 2 1 0 2 2 2 1 PDZ domain PDZ PF00595.24 VDK83350.1 - 0.064 13.6 0.0 7.4 7.0 0.0 2.9 3 0 0 3 3 3 0 PDZ domain TPR_1 PF00515.28 VDK83351.1 - 3e-23 80.6 11.2 1.3e-05 24.8 0.5 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 VDK83351.1 - 1.4e-20 72.1 13.8 2.6e-05 24.3 0.1 5.0 6 0 0 6 6 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 VDK83351.1 - 6.1e-20 69.7 8.4 0.00015 21.6 0.7 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDK83351.1 - 7.7e-18 63.2 6.9 0.0013 18.8 0.0 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 VDK83351.1 - 8.7e-18 63.7 11.2 6.5e-06 25.7 0.2 5.3 3 3 2 5 5 5 3 TPR repeat TPR_19 PF14559.6 VDK83351.1 - 9.5e-16 58.1 2.8 8.1e-05 23.1 0.2 4.2 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 VDK83351.1 - 1.1e-12 48.1 7.0 6.8e-06 26.3 1.5 3.9 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 VDK83351.1 - 1.3e-12 47.4 0.2 0.08 13.8 0.2 4.6 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 VDK83351.1 - 1.5e-10 41.5 3.5 5.1e-06 27.0 0.5 3.7 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 VDK83351.1 - 3.3e-09 36.3 12.4 0.00021 21.0 0.6 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 VDK83351.1 - 7.4e-08 31.9 1.0 0.65 10.2 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK83351.1 - 0.00012 22.3 5.6 0.32 11.2 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 VDK83351.1 - 0.00016 21.8 0.0 0.052 13.7 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF1736 PF08409.11 VDK83351.1 - 0.00022 21.1 0.1 0.00059 19.8 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1736) TPR_15 PF13429.6 VDK83351.1 - 0.003 16.8 1.3 0.031 13.5 0.4 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF4014 PF13198.6 VDK83351.1 - 0.052 13.9 1.9 0.052 13.9 1.9 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4014) Fis1_TPR_C PF14853.6 VDK83351.1 - 0.08 13.0 1.1 0.68 10.1 0.0 2.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 VDK83351.1 - 0.16 12.6 5.4 29 5.6 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4956 PF16316.5 VDK83351.1 - 0.23 11.1 6.0 2 8.1 5.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4956) TPR_20 PF14561.6 VDK83351.1 - 0.49 10.8 2.0 54 4.2 0.0 3.0 2 1 2 4 4 4 0 Tetratricopeptide repeat Glyco_hydro_38C PF07748.13 VDK83361.1 - 2e-18 67.3 0.0 3e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro38C2 PF17677.1 VDK83361.1 - 8.2e-07 29.1 0.0 1.3e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_38N PF01074.22 VDK83362.1 - 7.2e-76 255.3 1.2 1.1e-75 254.7 1.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 VDK83362.1 - 1.9e-18 66.4 0.0 4.9e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 VDK83362.1 - 3.2e-16 60.1 0.1 6.6e-16 59.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro_57 PF03065.15 VDK83362.1 - 0.0024 17.1 0.0 0.005 16.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 ECH_1 PF00378.20 VDK83366.1 - 2.3e-73 246.6 0.2 3.5e-73 246.0 0.2 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 VDK83366.1 - 4.5e-28 98.7 0.9 1.3e-20 74.2 0.4 2.6 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 VDK83366.1 - 0.0014 18.6 0.0 0.7 9.8 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 DUF5444 PF17519.2 VDK83366.1 - 0.18 11.8 0.2 0.52 10.3 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5444) Helicase_C_2 PF13307.6 VDK83367.1 - 8.2e-52 175.8 0.2 3.9e-51 173.6 0.0 2.2 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 VDK83367.1 - 1e-47 162.0 4.4 2.2e-47 160.9 4.4 1.6 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 VDK83367.1 - 1.2e-06 28.4 0.6 3.4e-05 23.7 0.2 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK83367.1 - 5.2e-06 26.6 0.4 4.9e-05 23.4 0.2 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit HBB PF06777.11 VDK83367.1 - 0.0019 17.9 0.1 0.0073 16.0 0.0 2.0 2 0 0 2 2 2 1 Helical and beta-bridge domain PhoH PF02562.16 VDK83367.1 - 0.1 12.0 0.4 0.71 9.3 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein Cmc1 PF08583.10 VDK83367.1 - 0.42 10.7 3.7 3.9 7.6 0.1 2.9 3 0 0 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like TraT PF05818.12 VDK83377.1 - 0.91 9.2 6.4 0.66 9.6 5.1 1.4 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein GRP PF07172.11 VDK83378.1 - 0.0016 19.1 6.9 0.002 18.8 6.9 1.1 1 0 0 1 1 1 1 Glycine rich protein family Herpes_capsid PF06112.11 VDK83378.1 - 5.3 7.1 7.9 6.8 6.7 7.9 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Thia_YuaJ PF09515.10 VDK83379.1 - 0.0098 15.9 0.2 0.01 15.9 0.2 1.1 1 0 0 1 1 1 1 Thiamine transporter protein (Thia_YuaJ) SARAF PF06682.12 VDK83380.1 - 0.012 15.3 1.7 0.013 15.1 1.7 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Activator_LAG-3 PF11498.8 VDK83380.1 - 0.051 12.5 14.0 0.061 12.3 14.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 VDK83380.1 - 0.056 13.4 6.8 0.059 13.4 6.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 VDK83380.1 - 1.4 7.8 7.2 1.9 7.3 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 VDK83380.1 - 2.9 7.4 13.1 4.3 6.9 13.1 1.2 1 0 0 1 1 1 0 Spt20 family TTR-52 PF01060.23 VDK83383.1 - 4.2e-06 27.4 0.1 9.3e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 Transthyretin-like family CBF_beta PF02312.17 VDK83385.1 - 5.2e-22 78.3 0.1 5.3e-21 75.0 0.1 2.2 1 1 0 1 1 1 1 Core binding factor beta subunit SWIRM-assoc_1 PF16495.5 VDK83385.1 - 0.066 13.2 1.6 0.097 12.6 0.0 2.0 2 0 0 2 2 2 0 SWIRM-associated region 1 PXB PF12828.7 VDK83385.1 - 0.087 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 PX-associated Ribosomal_L37 PF08561.10 VDK83387.1 - 2.3e-07 31.3 0.2 2.6e-07 31.2 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 ADAM_CR_2 PF17771.1 VDK83393.1 - 2.9e-07 30.9 15.3 1.2e-05 25.8 1.9 5.4 3 2 1 4 4 4 2 ADAM cysteine-rich domain TSP_1 PF00090.19 VDK83393.1 - 6.2e-05 23.1 7.3 6.2e-05 23.1 7.3 5.6 6 1 0 6 6 6 2 Thrombospondin type 1 domain Antistasin PF02822.14 VDK83393.1 - 0.082 13.6 0.3 0.082 13.6 0.3 4.8 6 0 0 6 6 6 0 Antistasin family Reprolysin PF01421.19 VDK83394.1 - 1.5e-12 47.9 1.8 2.5e-12 47.1 1.8 1.4 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_5 PF13688.6 VDK83394.1 - 3.6e-10 40.3 3.6 9.3e-10 39.0 3.6 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 VDK83394.1 - 1.4e-07 31.4 0.1 2.2e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 VDK83394.1 - 1.9e-07 31.2 0.0 2.5e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 VDK83394.1 - 4.4e-06 27.2 0.2 6.1e-06 26.8 0.2 1.5 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 VDK83394.1 - 0.0054 15.7 0.0 0.008 15.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M10 PF00413.24 VDK83394.1 - 0.0091 15.9 0.3 0.011 15.6 0.3 1.3 1 1 0 1 1 1 1 Matrixin Acetyltransf_1 PF00583.25 VDK83395.1 - 3.3e-12 46.7 0.0 7.6e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 VDK83395.1 - 4.2e-09 36.4 0.2 1.7e-08 34.5 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 VDK83395.1 - 2.5e-08 34.2 0.0 5.2e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 VDK83395.1 - 0.001 19.2 0.0 0.0035 17.5 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CtsR_C PF17727.1 VDK83395.1 - 0.0031 17.6 2.5 0.011 15.8 2.5 1.9 1 0 0 1 1 1 1 CtsR C-terminal dimerization domain FR47 PF08445.10 VDK83395.1 - 0.0039 17.1 0.0 0.0094 15.9 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 VDK83395.1 - 0.032 13.9 0.0 0.059 13.0 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 VDK83395.1 - 0.076 13.1 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain BIR PF00653.21 VDK83397.1 - 4.2e-21 75.4 0.3 6.2e-21 74.8 0.3 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 VDK83397.1 - 0.00056 19.9 0.2 0.0011 19.0 0.0 1.6 2 0 0 2 2 2 1 C3HC zinc finger-like DUF3694 PF12473.8 VDK83399.1 - 1.2e-26 94.2 0.2 8.5e-26 91.5 0.2 2.3 1 1 0 1 1 1 1 Kinesin protein PID PF00640.23 VDK83399.1 - 4.5e-06 26.8 0.1 1.4e-05 25.2 0.1 1.8 1 1 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 VDK83399.1 - 0.00016 21.9 0.0 0.00029 21.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain RabGAP-TBC PF00566.18 VDK83400.1 - 2.5e-50 171.1 1.4 5.5e-50 170.0 1.4 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain YabA PF06156.13 VDK83400.1 - 0.033 14.8 16.5 0.035 14.7 0.9 3.6 2 1 1 3 3 3 0 Initiation control protein YabA UPF0242 PF06785.11 VDK83400.1 - 0.07 13.2 26.2 1.2 9.2 1.8 3.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Rootletin PF15035.6 VDK83400.1 - 0.076 13.0 24.6 0.035 14.1 3.0 2.5 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion zf-C2H2_9 PF16293.5 VDK83400.1 - 0.17 11.7 0.7 0.53 10.2 0.1 2.1 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) APG6_N PF17675.1 VDK83400.1 - 0.23 12.0 24.4 2.8 8.5 0.9 3.4 1 1 1 3 3 3 0 Apg6 coiled-coil region DUF1090 PF06476.12 VDK83400.1 - 0.53 10.4 8.0 4.7 7.4 0.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1090) TMF_TATA_bd PF12325.8 VDK83400.1 - 2.2 8.5 25.0 0.076 13.2 11.4 3.3 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding Spc24 PF08286.11 VDK83400.1 - 4.1 7.7 17.2 0.1 12.8 1.6 3.7 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 ZapB PF06005.12 VDK83400.1 - 4.2 7.9 17.9 1.3 9.5 1.8 3.7 2 1 1 3 3 3 0 Cell division protein ZapB DUF1664 PF07889.12 VDK83400.1 - 9.4 6.3 7.6 13 5.9 1.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) GalKase_gal_bdg PF10509.9 VDK83410.1 - 1.7e-20 72.3 0.0 3.4e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 VDK83410.1 - 3.1e-16 59.5 0.2 7.3e-15 55.1 0.0 2.8 2 0 0 2 2 2 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 VDK83410.1 - 5.1e-14 52.3 0.9 1.8e-13 50.5 0.9 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain Nup54 PF13874.6 VDK83412.1 - 3.5e-35 121.1 4.2 3.5e-35 121.1 4.2 1.9 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 DEAD PF00270.29 VDK83412.1 - 2.6e-29 102.2 0.0 7.3e-29 100.8 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK83412.1 - 2.2e-25 89.1 0.4 1.3e-24 86.7 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK83412.1 - 4.1e-08 33.4 0.0 2.2e-07 31.0 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MnmE_helical PF12631.7 VDK83412.1 - 0.014 15.5 1.3 0.056 13.6 0.1 2.4 2 0 0 2 2 2 0 MnmE helical domain HWE_HK PF07536.14 VDK83412.1 - 0.019 15.6 4.6 0.22 12.3 0.6 3.5 3 0 0 3 3 3 0 HWE histidine kinase Nucleoporin_FG PF13634.6 VDK83412.1 - 3.8 8.4 22.1 17 6.3 21.6 2.4 2 1 0 2 2 2 0 Nucleoporin FG repeat region AAA_22 PF13401.6 VDK83412.1 - 6.6 7.0 9.6 3 8.1 1.5 3.7 3 1 0 3 3 3 0 AAA domain Tom37 PF10568.9 VDK83413.1 - 1.1e-29 103.3 0.1 3.3e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 VDK83413.1 - 1.7e-23 83.2 0.0 3.2e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 VDK83413.1 - 6e-22 77.2 0.2 1.8e-21 75.7 0.2 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 VDK83413.1 - 0.00052 20.0 0.0 0.00082 19.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 VDK83413.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Zona_pellucida PF00100.23 VDK83414.1 - 8.1e-05 22.5 0.0 0.00014 21.8 0.0 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain SSrecog PF03531.14 VDK83416.1 - 0.078 12.9 0.0 0.094 12.6 0.0 1.2 1 0 0 1 1 1 0 Structure-specific recognition protein (SSRP1) zf-HC5HC2H_2 PF13832.6 VDK83417.1 - 7.8e-28 96.8 10.0 7.8e-28 96.8 10.0 2.2 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 VDK83417.1 - 1.8e-20 73.0 6.4 1.8e-20 73.0 6.4 3.4 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 VDK83417.1 - 3e-12 45.9 3.5 3e-12 45.9 3.5 3.2 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 VDK83417.1 - 2.1e-09 37.1 11.1 2.1e-09 37.1 11.1 3.4 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.9 VDK83417.1 - 0.00035 21.0 0.0 0.00064 20.1 0.0 1.5 1 1 0 1 1 1 1 Enhancer of polycomb-like Prok-RING_1 PF14446.6 VDK83417.1 - 3.4 7.7 22.5 0.13 12.2 8.1 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-HC5HC2H_2 PF13832.6 VDK83420.1 - 7.8e-28 96.8 10.0 7.8e-28 96.8 10.0 2.2 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 VDK83420.1 - 1.8e-20 73.0 6.4 1.8e-20 73.0 6.4 3.4 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 VDK83420.1 - 3e-12 45.9 3.5 3e-12 45.9 3.5 3.2 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 VDK83420.1 - 2.1e-09 37.1 11.1 2.1e-09 37.1 11.1 3.4 3 0 0 3 3 3 2 PHD-finger EPL1 PF10513.9 VDK83420.1 - 0.00035 21.0 0.0 0.00064 20.1 0.0 1.5 1 1 0 1 1 1 1 Enhancer of polycomb-like Prok-RING_1 PF14446.6 VDK83420.1 - 3.4 7.7 22.5 0.13 12.2 8.1 2.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 HemY_N PF07219.13 VDK83426.1 - 0.015 15.5 0.6 0.036 14.3 0.6 1.6 1 0 0 1 1 1 0 HemY protein N-terminus zf-rbx1 PF12678.7 VDK83427.1 - 2.7e-25 88.4 12.9 4e-25 87.9 12.9 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 VDK83427.1 - 2.9e-17 62.5 9.9 4e-17 62.1 9.9 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 VDK83427.1 - 3.1e-06 27.4 14.6 9.9e-05 22.6 14.6 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 VDK83427.1 - 0.0023 17.8 11.9 0.031 14.1 11.9 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK83427.1 - 0.0047 16.7 14.9 0.28 11.0 14.9 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK83427.1 - 0.28 11.1 11.2 0.61 10.0 4.8 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 VDK83427.1 - 0.28 11.0 15.3 0.21 11.3 8.5 2.5 1 1 1 2 2 2 0 RING-like zinc finger FANCL_C PF11793.8 VDK83427.1 - 0.63 10.3 9.2 3.1 8.0 9.4 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 VDK83427.1 - 0.64 9.7 15.4 0.09 12.4 5.1 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 VDK83427.1 - 0.64 10.1 7.9 2.4 8.3 7.9 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C2H2_9 PF16293.5 VDK83428.1 - 0.026 14.4 0.2 0.043 13.7 0.2 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (1 copy) DUF3793 PF12672.7 VDK83428.1 - 0.072 13.1 0.1 0.14 12.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3793) Acetyltransf_1 PF00583.25 VDK83431.1 - 1.1e-12 48.3 0.1 1.5e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 VDK83431.1 - 6.8e-08 32.8 0.3 9.3e-08 32.4 0.3 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 VDK83431.1 - 1.8e-07 31.1 0.4 2.2e-07 30.8 0.4 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 VDK83431.1 - 5.5e-05 23.1 0.0 9.2e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 VDK83431.1 - 0.00052 20.1 0.1 0.0008 19.5 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Melibiase_2 PF16499.5 VDK83431.1 - 0.043 13.0 0.1 0.07 12.3 0.0 1.3 2 0 0 2 2 2 0 Alpha galactosidase A DUF4536 PF15055.6 VDK83432.1 - 0.0015 18.7 1.4 0.0022 18.2 0.8 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4536) PTRF_SDPR PF15237.6 VDK83434.1 - 0.0063 16.2 3.3 0.01 15.5 3.3 1.3 1 0 0 1 1 1 1 PTRF/SDPR family MCR_C PF04609.12 VDK83434.1 - 0.012 14.7 0.8 0.96 8.5 0.1 2.1 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein C AAA_PrkA PF08298.11 VDK83434.1 - 0.02 13.8 0.1 0.033 13.1 0.1 1.3 1 1 0 1 1 1 0 PrkA AAA domain BLOC1_2 PF10046.9 VDK83434.1 - 0.023 15.0 6.0 0.32 11.3 0.3 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TerD PF02342.18 VDK83434.1 - 0.028 13.9 1.1 0.042 13.3 0.5 1.5 1 1 1 2 2 2 0 TerD domain DUF3161 PF11362.8 VDK83434.1 - 0.088 12.8 0.1 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3161) TP_methylase PF00590.20 VDK83434.1 - 0.098 12.6 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases Hrs_helical PF12210.8 VDK83434.1 - 0.13 12.9 5.3 2.9 8.5 1.3 2.3 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate zf-C4H2 PF10146.9 VDK83434.1 - 0.22 11.8 3.4 0.49 10.7 3.4 1.5 1 1 0 1 1 1 0 Zinc finger-containing protein CorA PF01544.18 VDK83434.1 - 0.35 10.1 4.1 0.44 9.8 4.1 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Tropomyosin_1 PF12718.7 VDK83434.1 - 0.54 10.4 8.9 0.5 10.5 1.7 2.2 1 1 0 2 2 2 0 Tropomyosin like Uso1_p115_C PF04871.13 VDK83434.1 - 0.59 10.5 8.0 2.1 8.7 1.2 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region POX PF07526.11 VDK83434.1 - 0.61 10.7 3.6 0.89 10.1 0.2 2.4 2 1 1 3 3 3 0 Associated with HOX Prefoldin_2 PF01920.20 VDK83434.1 - 1.3 9.0 7.8 1.6 8.7 0.5 2.2 2 0 0 2 2 2 0 Prefoldin subunit HU-CCDC81_bac_2 PF18175.1 VDK83434.1 - 2.5 8.0 4.6 23 4.9 0.4 2.3 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 WD40 PF00400.32 VDK83436.1 - 7.3e-07 29.8 5.0 0.066 14.1 0.0 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK83436.1 - 0.00055 20.2 0.0 0.095 13.0 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SAM_2 PF07647.17 VDK83443.1 - 2e-08 34.2 0.3 3.5e-08 33.4 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 VDK83443.1 - 3.4e-05 24.2 0.5 5.5e-05 23.5 0.5 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 VDK83443.1 - 0.052 13.5 0.2 0.092 12.7 0.2 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Aa_trans PF01490.18 VDK83444.1 - 5.9e-71 239.3 32.1 7.5e-71 239.0 32.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Gp-FAR-1 PF05823.12 VDK83445.1 - 7.5e-46 156.2 13.0 8.6e-46 156.0 13.0 1.0 1 0 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF3106 PF11304.8 VDK83445.1 - 0.0015 19.0 1.5 0.059 13.8 1.2 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF3106) Syntaxin PF00804.25 VDK83445.1 - 0.0019 17.9 4.0 0.0026 17.5 4.0 1.2 1 0 0 1 1 1 1 Syntaxin DUF2063 PF09836.9 VDK83445.1 - 0.0068 16.6 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 Putative DNA-binding domain DctP PF03480.13 VDK83445.1 - 0.0075 15.6 0.7 0.0075 15.6 0.7 2.0 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein, family 7 PET10 PF17316.2 VDK83445.1 - 0.0091 15.6 3.3 0.012 15.2 0.3 2.0 1 1 1 2 2 2 1 Petite colonies protein 10 DUF3435 PF11917.8 VDK83445.1 - 0.013 14.5 2.9 0.016 14.2 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) ApoLp-III PF07464.11 VDK83445.1 - 0.014 15.5 3.2 3.9 7.5 0.3 2.2 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) SieB PF14163.6 VDK83445.1 - 0.02 14.4 0.4 0.25 10.8 0.0 2.3 1 1 1 2 2 2 0 Super-infection exclusion protein B EF-G-binding_N PF07299.11 VDK83445.1 - 0.028 14.9 4.0 0.04 14.4 0.6 2.6 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal YkyA PF10368.9 VDK83445.1 - 0.056 13.1 12.7 0.15 11.8 10.5 2.4 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein TAFII28 PF04719.14 VDK83445.1 - 0.068 13.3 1.1 0.091 12.9 0.2 1.9 2 0 0 2 2 1 0 hTAFII28-like protein conserved region ARL2_Bind_BART PF11527.8 VDK83445.1 - 0.14 12.3 2.2 0.57 10.3 0.3 2.4 1 1 0 2 2 2 0 The ARF-like 2 binding protein BART HGD-D PF06050.13 VDK83445.1 - 0.14 11.9 4.0 0.29 10.9 3.7 1.7 1 1 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component HsbA PF12296.8 VDK83445.1 - 0.23 11.9 2.9 0.43 11.0 1.3 2.2 2 1 0 2 2 2 0 Hydrophobic surface binding protein A TEX12 PF15219.6 VDK83445.1 - 0.25 11.7 3.9 0.092 13.1 0.9 1.8 2 0 0 2 2 2 0 Testis-expressed 12 CHASE3 PF05227.13 VDK83445.1 - 0.27 11.1 3.5 0.36 10.7 3.5 1.2 1 0 0 1 1 1 0 CHASE3 domain DUF3365 PF11845.8 VDK83445.1 - 0.31 11.4 2.0 2.5 8.4 2.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3365) Fzo_mitofusin PF04799.13 VDK83445.1 - 0.32 10.5 2.3 0.39 10.3 0.5 1.9 1 1 0 2 2 2 0 fzo-like conserved region DUF3919 PF13057.6 VDK83445.1 - 0.38 10.3 4.5 3.1 7.3 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3919) VSG_B PF13206.6 VDK83445.1 - 0.75 9.0 6.1 0.86 8.8 6.1 1.0 1 0 0 1 1 1 0 Trypanosomal VSG domain FliD_N PF02465.18 VDK83445.1 - 0.78 10.5 5.4 7.9 7.3 1.8 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus YtxH PF12732.7 VDK83445.1 - 1.6 9.3 8.9 53 4.4 8.9 2.7 1 1 0 1 1 1 0 YtxH-like protein Pet100 PF09803.9 VDK83445.1 - 2.3 8.8 5.8 2.7 8.6 0.3 2.9 1 1 1 2 2 2 0 Pet100 AAA_6 PF12774.7 VDK83447.1 - 6.8e-127 422.9 0.2 4.3e-126 420.3 0.0 2.5 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 VDK83447.1 - 9e-119 397.6 16.2 9e-119 397.6 16.2 3.4 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 VDK83447.1 - 7.6e-112 374.3 15.1 7.6e-112 374.3 15.1 6.1 4 2 2 7 7 7 1 Dynein heavy chain, N-terminal region 2 AAA_5 PF07728.14 VDK83447.1 - 4.5e-19 68.8 0.1 2e-13 50.5 0.0 3.5 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 VDK83447.1 - 8.6e-11 42.0 0.5 4.7e-10 39.7 0.1 2.7 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 VDK83447.1 - 3.2e-06 27.6 0.7 0.05 14.0 0.0 4.5 5 0 0 5 5 3 2 AAA ATPase domain AAA_22 PF13401.6 VDK83447.1 - 1.9e-05 25.0 0.1 0.074 13.3 0.0 3.7 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.6 VDK83447.1 - 7.1e-05 23.0 0.0 0.003 17.7 0.0 3.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 VDK83447.1 - 0.00051 20.5 2.1 0.27 11.7 0.0 3.8 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 VDK83447.1 - 0.00064 20.3 0.1 1 9.9 0.0 4.1 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 VDK83447.1 - 0.0015 18.1 0.1 1.3 8.5 0.0 3.4 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_30 PF13604.6 VDK83447.1 - 0.0055 16.5 0.9 0.76 9.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 VDK83447.1 - 0.0062 15.9 0.1 0.026 13.9 0.0 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_24 PF13479.6 VDK83447.1 - 0.068 12.9 0.0 20 4.8 0.0 3.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 VDK83447.1 - 0.11 12.8 0.0 5.6 7.2 0.0 3.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 VDK83447.1 - 0.13 12.7 0.0 11 6.5 0.0 3.0 2 0 0 2 2 2 0 RNA helicase Goodbye PF17109.5 VDK83447.1 - 6.7 7.2 6.4 4.3 7.8 0.4 4.1 4 0 0 4 4 3 0 fungal STAND N-terminal Goodbye domain TMPIT PF07851.13 VDK83455.1 - 4.7e-123 410.6 10.0 5.4e-123 410.4 10.0 1.0 1 0 0 1 1 1 1 TMPIT-like protein K-box PF01486.17 VDK83455.1 - 0.29 11.3 4.3 4.5 7.5 0.1 2.7 2 1 1 3 3 3 0 K-box region DEAD PF00270.29 VDK83458.1 - 8e-43 146.2 0.1 1.2e-42 145.6 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK83458.1 - 1.4e-29 102.7 1.0 2.1e-28 98.8 0.7 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 VDK83458.1 - 0.14 11.4 0.1 0.28 10.5 0.1 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF842 PF05811.13 VDK83459.1 - 1.4e-41 141.2 4.4 1.6e-41 141.1 4.4 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) zf-Tim10_DDP PF02953.15 VDK83459.1 - 0.0075 15.9 0.2 0.0075 15.9 0.2 2.6 1 1 2 3 3 3 1 Tim10/DDP family zinc finger Ank_4 PF13637.6 VDK83459.1 - 0.11 13.1 0.0 0.26 11.9 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) FHA PF00498.26 VDK83460.1 - 3.6e-18 65.7 0.4 9.7e-18 64.3 0.4 1.8 1 0 0 1 1 1 1 FHA domain dsrm PF00035.26 VDK83460.1 - 3.6e-08 34.0 0.2 1.4e-07 32.1 0.0 2.2 2 0 0 2 2 2 1 Double-stranded RNA binding motif Yop-YscD_cpl PF16697.5 VDK83460.1 - 5.5e-07 29.8 0.0 1.6e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Dicer_dimer PF03368.14 VDK83460.1 - 0.0001 22.4 0.0 0.00044 20.3 0.0 2.1 2 0 0 2 2 2 1 Dicer dimerisation domain DUF1980 PF09323.10 VDK83460.1 - 0.75 9.7 3.4 1.4 8.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) APG6_N PF17675.1 VDK83460.1 - 4.5 7.8 14.9 0.04 14.5 4.2 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region His_Phos_2 PF00328.22 VDK83462.1 - 3.3e-22 79.4 3.6 3.5e-21 76.0 0.4 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) His_Phos_1 PF00300.22 VDK83462.1 - 0.087 12.5 0.0 0.34 10.6 0.0 1.9 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) Nop14 PF04147.12 VDK83463.1 - 5.7e-140 468.2 37.0 5.4e-139 465.0 37.0 2.0 1 1 0 1 1 1 1 Nop14-like family Egh16-like PF11327.8 VDK83463.1 - 0.18 12.2 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 Egh16-like virulence factor GOLD_2 PF13897.6 VDK83463.1 - 5.1 7.6 11.1 0.21 12.1 0.3 3.1 1 1 2 3 3 3 0 Golgi-dynamics membrane-trafficking Ssl1 PF04056.14 VDK83464.1 - 6.4e-33 114.2 0.0 8.9e-33 113.7 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 VDK83464.1 - 3.9e-10 39.8 12.0 3.9e-10 39.8 12.0 3.2 2 2 0 2 2 2 1 TFIIH C1-like domain DZR PF12773.7 VDK83464.1 - 0.0022 18.0 16.2 8.3 6.5 16.2 2.9 1 1 0 1 1 1 1 Double zinc ribbon zf-HIT PF04438.16 VDK83464.1 - 0.0029 17.5 1.0 0.0029 17.5 1.0 3.8 5 0 0 5 5 5 1 HIT zinc finger Defensin_big PF14862.6 VDK83464.1 - 0.1 13.0 0.5 0.1 13.0 0.5 2.3 2 0 0 2 2 2 0 Big defensin IBR PF01485.21 VDK83464.1 - 0.72 10.1 19.5 0.66 10.2 9.2 3.0 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 VDK83464.1 - 4.1 7.3 22.2 0.23 11.3 7.9 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pribosyltran_N PF13793.6 VDK83466.1 - 1.5e-46 157.1 2.0 6.9e-46 154.9 0.2 2.4 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 VDK83466.1 - 7.2e-43 146.7 1.2 7.1e-36 124.0 0.3 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 VDK83466.1 - 3.4e-14 52.6 0.2 6.7e-14 51.7 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 VDK83466.1 - 4.2e-05 23.1 0.1 8.4e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase SpoVIF PF14069.6 VDK83469.1 - 0.039 13.7 0.3 0.077 12.8 0.3 1.5 1 0 0 1 1 1 0 Stage VI sporulation protein F BLI1 PF17324.2 VDK83469.1 - 0.073 13.7 0.0 1.1 9.9 0.0 2.3 1 1 1 2 2 2 0 BLOC-1 interactor 1 DUF1115 PF06544.12 VDK83470.1 - 7.9e-07 29.3 1.0 4e-06 27.0 0.0 2.2 2 1 1 3 3 3 1 Protein of unknown function (DUF1115) RWD PF05773.22 VDK83470.1 - 0.0072 16.6 0.2 0.013 15.7 0.2 1.5 1 0 0 1 1 1 1 RWD domain HLH PF00010.26 VDK83475.1 - 2.6e-08 33.7 1.0 5.4e-06 26.3 0.1 2.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DivIC PF04977.15 VDK83475.1 - 0.0056 16.4 1.0 0.023 14.4 1.0 2.1 1 0 0 1 1 1 1 Septum formation initiator Cortex-I_coil PF09304.10 VDK83475.1 - 0.0066 16.7 0.9 0.021 15.0 0.9 1.8 1 0 0 1 1 1 1 Cortexillin I, coiled coil Paralemmin PF03285.15 VDK83475.1 - 0.018 14.6 1.2 0.018 14.6 1.2 1.8 2 0 0 2 2 2 0 Paralemmin Lzipper-MIP1 PF14389.6 VDK83475.1 - 0.056 13.8 1.4 0.22 11.9 0.2 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Sin3_corepress PF08295.12 VDK83475.1 - 0.084 13.0 0.2 0.24 11.5 0.2 1.8 1 0 0 1 1 1 0 Sin3 family co-repressor DUF3492 PF11997.8 VDK83475.1 - 0.13 11.9 1.8 0.23 11.2 1.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3492) DUF16 PF01519.16 VDK83475.1 - 0.2 12.2 1.4 0.59 10.7 1.4 1.8 1 0 0 1 1 1 0 Protein of unknown function DUF16 SseC PF04888.12 VDK83475.1 - 0.22 11.1 2.8 0.36 10.4 2.8 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family SlyX PF04102.12 VDK83475.1 - 0.26 12.0 4.7 0.094 13.3 1.2 2.1 2 0 0 2 2 2 0 SlyX DUF3847 PF12958.7 VDK83475.1 - 1.2 9.3 6.1 0.15 12.2 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) TMF_TATA_bd PF12325.8 VDK83475.1 - 4.2 7.6 10.1 0.11 12.7 3.4 1.8 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding DUF1192 PF06698.11 VDK83475.1 - 6.1 7.0 8.3 9.4 6.4 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Fib_alpha PF08702.10 VDK83475.1 - 8.8 6.5 8.5 0.25 11.5 0.7 2.5 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 VDK83476.1 - 0.00053 20.6 0.0 0.002 18.7 0.0 2.0 2 0 0 2 2 2 1 SlyX NPV_P10 PF05531.12 VDK83477.1 - 0.1 13.0 0.4 0.34 11.4 0.3 1.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF725 PF05267.12 VDK83477.1 - 0.13 12.2 0.2 0.72 9.9 0.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF725) SQS_PSY PF00494.19 VDK83482.1 - 1.7e-07 31.0 0.0 2e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase MMgT PF10270.9 VDK83483.1 - 2.2e-16 60.0 0.0 3.2e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Membrane magnesium transporter PRELI PF04707.14 VDK83484.1 - 2.6e-32 111.8 0.9 5.9e-32 110.7 0.9 1.6 1 0 0 1 1 1 1 PRELI-like family PXA PF02194.15 VDK83484.1 - 6.7e-26 91.4 5.5 7.8e-26 91.2 3.9 2.0 2 0 0 2 2 2 1 PXA domain PIG-P PF08510.12 VDK83484.1 - 5.5e-20 71.5 0.1 1.6e-19 70.0 0.1 1.8 1 0 0 1 1 1 1 PIG-P PX PF00787.24 VDK83484.1 - 3.6e-11 43.0 2.3 1.1e-10 41.5 0.5 2.7 3 0 0 3 3 3 1 PX domain RGS PF00615.19 VDK83484.1 - 2.6e-06 27.7 0.3 0.0001 22.6 0.0 2.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain Nexin_C PF08628.12 VDK83484.1 - 2.8e-05 24.7 0.1 0.00017 22.2 0.0 2.4 2 0 0 2 2 2 1 Sorting nexin C terminal DPM2 PF07297.12 VDK83484.1 - 0.00011 22.4 9.7 0.00045 20.5 9.7 2.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) MMR_HSR1 PF01926.23 VDK83484.1 - 0.0046 17.0 0.0 0.051 13.7 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase Read-through PF16814.5 VDK83484.1 - 0.093 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Read-through domain WASH_WAHD PF11945.8 VDK83486.1 - 1.2e-22 80.9 0.3 1.9e-22 80.2 0.3 1.3 1 0 0 1 1 1 1 WAHD domain of WASH complex Mito_fiss_reg PF05308.11 VDK83486.1 - 0.009 16.1 3.3 0.015 15.4 1.8 2.2 2 0 0 2 2 2 1 Mitochondrial fission regulator CAP_N PF01213.19 VDK83486.1 - 0.011 15.3 2.2 0.011 15.3 2.2 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Ssu72 PF04722.13 VDK83491.1 - 5.1e-68 228.4 0.1 6.7e-68 228.0 0.1 1.1 1 0 0 1 1 1 1 Ssu72-like protein DUF4030 PF13222.6 VDK83491.1 - 0.025 14.7 0.4 0.049 13.8 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4030) Methyltransf_31 PF13847.6 VDK83495.1 - 6.9e-17 61.6 0.0 1.3e-16 60.7 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK83495.1 - 1.5e-15 57.7 0.0 3.5e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK83495.1 - 1.5e-14 54.4 0.0 3.2e-14 53.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK83495.1 - 1.5e-11 44.9 0.0 2.6e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 VDK83495.1 - 2.4e-09 36.9 0.3 8e-09 35.2 0.3 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 VDK83495.1 - 3.1e-08 33.2 0.1 5.1e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 VDK83495.1 - 6.7e-08 32.5 0.0 1.3e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 VDK83495.1 - 3.9e-05 23.3 0.0 6.6e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 VDK83495.1 - 5.4e-05 22.7 0.0 0.00014 21.4 0.0 1.7 2 1 0 2 2 2 1 Putative methyltransferase MetW PF07021.12 VDK83495.1 - 0.052 13.1 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW BrkDBD PF09607.10 VDK83495.1 - 0.17 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 Brinker DNA-binding domain LRAT PF04970.13 VDK83498.1 - 3.6e-25 88.7 0.0 6.5e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Lecithin retinol acyltransferase Peptidase_C97 PF05903.14 VDK83498.1 - 0.018 14.9 0.3 0.049 13.5 0.3 1.7 1 0 0 1 1 1 0 PPPDE putative peptidase domain SH3_9 PF14604.6 VDK83499.1 - 2.1e-17 62.7 0.2 4.4e-17 61.7 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK83499.1 - 3.8e-12 45.6 0.0 5.8e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK83499.1 - 1.3e-06 27.9 0.1 2.7e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 VDK83500.1 - 4.7e-25 87.2 0.0 2.1e-12 46.7 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 VDK83500.1 - 8.4e-25 86.1 0.0 1.9e-11 43.4 0.0 2.9 3 0 0 3 3 3 2 SH3 domain SH3_2 PF07653.17 VDK83500.1 - 1.1e-20 73.1 0.0 2.2e-09 36.9 0.0 3.0 3 0 0 3 3 3 2 Variant SH3 domain Sorb PF02208.16 VDK83501.1 - 0.003 17.4 0.2 0.0074 16.1 0.2 1.6 1 0 0 1 1 1 1 Sorbin homologous domain DUF4698 PF15769.5 VDK83501.1 - 4.5 6.2 8.8 0.22 10.5 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4698) PRIMA1 PF16101.5 VDK83501.1 - 7.7 6.6 12.7 31 4.6 12.7 2.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 EF-hand_1 PF00036.32 VDK83507.1 - 1.4e-37 124.5 20.9 2.7e-09 35.9 0.2 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 VDK83507.1 - 4.5e-31 107.1 9.6 3.6e-15 56.2 0.2 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 VDK83507.1 - 3.5e-28 97.2 19.0 4.5e-13 48.8 4.2 4.3 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 VDK83507.1 - 4.7e-28 94.7 8.9 2.4e-09 36.3 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 VDK83507.1 - 3.2e-21 73.8 9.3 4e-06 26.1 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 VDK83507.1 - 4.3e-12 46.2 0.8 1.5e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 VDK83507.1 - 4.7e-09 36.1 4.0 0.00046 20.1 0.2 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDK83507.1 - 3.6e-07 30.5 0.7 0.0081 16.5 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 VDK83507.1 - 0.00059 19.8 7.3 0.099 12.7 0.1 3.4 3 1 1 4 4 4 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 VDK83507.1 - 0.0014 19.5 0.2 0.1 13.4 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain EFhand_Ca_insen PF08726.10 VDK83507.1 - 0.0029 17.7 2.5 0.019 15.1 0.3 2.6 2 1 1 3 3 3 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 VDK83507.1 - 0.003 17.7 1.2 0.53 10.5 0.7 3.0 1 1 1 2 2 2 1 Dockerin type I domain Caleosin PF05042.13 VDK83507.1 - 0.0058 16.6 0.9 2.7 7.9 0.0 3.2 1 1 1 3 3 3 1 Caleosin related protein Phage_TAC_12 PF12363.8 VDK83507.1 - 0.022 15.2 0.3 1.1 9.7 0.0 2.5 2 1 0 2 2 2 0 Phage tail assembly chaperone protein, TAC TerB PF05099.13 VDK83507.1 - 0.044 13.7 0.6 2.9 7.8 0.1 2.4 1 1 1 2 2 2 0 Tellurite resistance protein TerB FGAR-AT_linker PF18072.1 VDK83507.1 - 0.085 13.4 0.2 1 9.9 0.1 2.5 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain DUF3349 PF11829.8 VDK83507.1 - 0.097 13.5 0.2 7.8 7.4 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3349) MFP2b PF12150.8 VDK83508.1 - 3.6e-83 279.7 0.0 4.5e-83 279.4 0.0 1.0 1 0 0 1 1 1 1 Cytosolic motility protein PnpCD_PnpD_N PF18191.1 VDK83508.1 - 0.03 13.9 0.0 0.098 12.2 0.0 1.8 2 0 0 2 2 2 0 Hydroquinone 1,2-dioxygenase large subunit N-terminal Ank_2 PF12796.7 VDK83509.1 - 2.8e-16 59.9 5.8 1.1e-06 29.1 0.8 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK83509.1 - 2.9e-15 56.1 0.3 9.3e-08 32.2 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK83509.1 - 2.1e-14 52.2 1.8 1.6e-05 24.9 0.0 5.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 VDK83509.1 - 5.3e-14 52.4 0.7 1.9e-06 28.3 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 VDK83509.1 - 7.3e-11 42.0 0.5 0.069 13.6 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ion_trans PF00520.31 VDK83509.1 - 0.00047 19.5 34.7 0.003 16.8 34.7 2.0 1 1 0 1 1 1 1 Ion transport protein Molybdopterin PF00384.22 VDK83510.1 - 8.3e-67 226.0 0.0 1.2e-65 222.2 0.0 2.0 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 VDK83510.1 - 1.3e-18 66.8 0.0 2.5e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 VDK83510.1 - 1.9e-15 56.1 0.1 1.9e-15 56.1 0.1 2.6 3 0 0 3 3 3 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 VDK83510.1 - 1e-12 48.5 0.1 2.4e-12 47.4 0.1 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 VDK83510.1 - 3e-09 36.7 1.2 3.9e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 VDK83510.1 - 0.00035 20.3 0.4 0.038 13.7 0.1 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 VDK83510.1 - 8.4 6.4 8.1 8.4 6.4 0.4 3.3 3 0 0 3 3 3 0 4Fe-4S binding domain CcmH PF03918.14 VDK83512.1 - 0.027 13.7 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Zip PF02535.22 VDK83515.1 - 8.5e-46 156.7 9.3 1e-45 156.5 9.3 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF5367 PF17329.2 VDK83515.1 - 0.092 12.9 0.4 0.092 12.9 0.4 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5367) MatE PF01554.18 VDK83515.1 - 3.6 7.2 16.6 1.1 8.9 0.2 3.5 3 1 0 3 3 3 0 MatE Complex1_LYR PF05347.15 VDK83516.1 - 1.6e-07 31.2 0.2 1.6e-07 31.2 0.2 1.8 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Ank_5 PF13857.6 VDK83517.1 - 1.9e-18 66.2 0.1 1.4e-08 34.9 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK83517.1 - 5.8e-18 65.3 0.1 1.1e-17 64.3 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK83517.1 - 1.2e-16 60.8 0.1 3.6e-08 33.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) SH3_1 PF00018.28 VDK83517.1 - 1.2e-15 56.8 0.0 1.9e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 SH3 domain Ank PF00023.30 VDK83517.1 - 6.4e-15 54.8 1.0 4.1e-08 33.3 0.4 3.3 3 0 0 3 3 3 3 Ankyrin repeat SH3_9 PF14604.6 VDK83517.1 - 1.9e-13 50.0 0.0 2.8e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK83517.1 - 1.7e-12 46.8 0.0 3e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Ank_3 PF13606.6 VDK83517.1 - 7.5e-08 32.1 0.1 0.25 12.0 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat SH3_10 PF17902.1 VDK83517.1 - 0.002 18.1 0.0 0.015 15.3 0.0 2.1 2 0 0 2 2 2 1 SH3 domain Nop10p PF04135.12 VDK83519.1 - 7.2e-22 77.2 0.1 1.1e-21 76.6 0.1 1.3 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family FA_hydroxylase PF04116.13 VDK83521.1 - 8.2e-13 48.9 13.8 8.2e-13 48.9 13.8 2.1 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily Cyt-b5 PF00173.28 VDK83521.1 - 2e-09 37.5 0.8 2.4e-08 34.0 0.0 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain TMEM189_B_dmain PF10520.9 VDK83521.1 - 0.83 9.8 6.8 1.3 9.1 1.0 2.4 2 0 0 2 2 2 0 B domain of TMEM189, localisation domain OLF PF02191.16 VDK83523.1 - 1.5e-23 83.6 1.1 2.1e-23 83.1 1.1 1.2 1 0 0 1 1 1 1 Olfactomedin-like domain C2 PF00168.30 VDK83525.1 - 5.9e-12 45.8 0.0 8.2e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 C2 domain Cytochrom_C1 PF02167.15 VDK83531.1 - 3.3e-74 249.3 0.0 4.6e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 VDK83531.1 - 0.006 16.9 0.0 0.015 15.6 0.0 1.7 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 VDK83531.1 - 0.0071 17.5 0.3 0.015 16.4 0.3 1.8 1 1 0 1 1 1 1 Cytochrome c DUF2048 PF09752.9 VDK83532.1 - 1.6e-74 251.1 0.0 3.6e-65 220.4 0.0 2.0 1 1 1 2 2 2 2 Abhydrolase domain containing 18 Peptidase_S15 PF02129.18 VDK83532.1 - 0.032 13.8 0.1 0.046 13.3 0.1 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 VDK83532.1 - 0.11 11.8 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Maf PF02545.14 VDK83533.1 - 7.1e-51 172.3 0.0 8.3e-51 172.1 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein Pkinase PF00069.25 VDK83534.1 - 3.7e-129 429.7 0.0 1.2e-64 218.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK83534.1 - 1.2e-62 211.6 0.0 2.5e-30 105.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 VDK83534.1 - 1.3e-12 47.7 0.0 2.8e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 VDK83534.1 - 2.1e-09 37.7 0.0 0.0028 17.6 0.0 3.6 3 1 1 4 4 4 3 Phosphotransferase enzyme family Kdo PF06293.14 VDK83534.1 - 1.9e-08 33.9 0.3 9.8e-06 25.1 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 VDK83534.1 - 2.3e-07 30.1 0.8 0.013 14.5 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain Pkinase_C PF00433.24 VDK83534.1 - 5.9e-07 30.1 2.1 6.6e-07 29.9 0.4 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Pkinase_fungal PF17667.1 VDK83534.1 - 3.5e-06 26.1 0.0 0.023 13.5 0.0 2.8 2 1 1 3 3 3 2 Fungal protein kinase RIO1 PF01163.22 VDK83534.1 - 9.5e-05 22.1 1.0 0.0055 16.3 0.1 2.3 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.9 VDK83534.1 - 0.0068 15.9 0.1 0.2 11.2 0.0 2.4 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 VDK83534.1 - 0.007 16.0 0.1 0.04 13.5 0.0 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase SAM_decarbox PF01536.16 VDK83536.1 - 1.2e-102 343.6 0.0 1.4e-102 343.4 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase Pkinase PF00069.25 VDK83539.1 - 3.5e-17 62.6 0.2 9e-17 61.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK83539.1 - 7.5e-12 45.1 0.0 1.2e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 VDK83543.1 - 5.8e-16 58.6 10.5 9.9e-07 29.4 0.0 5.7 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK83543.1 - 8.7e-07 29.2 0.2 0.061 13.6 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH_TPL PF17814.1 VDK83543.1 - 2.2e-05 24.0 0.0 4.5e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 LisH-like dimerisation domain Ge1_WD40 PF16529.5 VDK83543.1 - 0.0077 15.2 0.5 6.5 5.6 0.0 3.4 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_3 PF15911.5 VDK83543.1 - 0.11 12.5 0.0 0.41 10.7 0.0 2.0 1 0 0 1 1 1 0 WD domain, G-beta repeat MFS_1 PF07690.16 VDK83544.1 - 2.5e-41 141.8 35.6 5.2e-36 124.3 29.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily COMPASS-Shg1 PF05205.12 VDK83547.1 - 3.1e-09 37.5 0.1 5.7e-09 36.6 0.1 1.6 1 1 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 DUF2608 PF11019.8 VDK83547.1 - 0.069 12.6 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) TelA PF05816.11 VDK83547.1 - 0.07 12.2 0.3 0.085 11.9 0.3 1.1 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) DUF4844 PF16133.5 VDK83547.1 - 0.1 13.2 0.1 0.16 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) VWA PF00092.28 VDK83549.1 - 1.4e-59 201.3 0.7 2.4e-30 106.1 0.1 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 VDK83549.1 - 1.3e-31 109.4 0.1 9e-16 58.5 0.0 2.7 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 VDK83549.1 - 2.6e-13 49.9 0.0 8.6e-09 35.1 0.0 2.5 2 1 0 2 2 2 2 VWA domain containing CoxE-like protein VWA_3 PF13768.6 VDK83549.1 - 6.5e-06 26.2 0.0 0.061 13.3 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain DUF1194 PF06707.11 VDK83549.1 - 1.8e-05 24.0 2.7 0.00019 20.7 0.0 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF1194) vWA-TerF-like PF10138.9 VDK83549.1 - 5.4e-05 23.4 2.4 0.008 16.3 0.0 3.0 3 0 0 3 3 3 2 vWA found in TerF C terminus WD40 PF00400.32 VDK83551.1 - 8.6e-41 137.2 18.0 1.9e-07 31.6 0.5 11.8 11 1 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK83551.1 - 1.8e-22 79.5 1.0 5.6e-06 26.6 0.0 8.5 4 2 6 10 10 10 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK83551.1 - 1.4e-13 51.2 0.2 6.1e-05 23.0 0.1 4.6 2 1 3 5 5 5 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 VDK83551.1 - 4.6e-08 32.8 8.7 2.5 8.1 0.0 7.6 8 0 0 8 8 8 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 VDK83551.1 - 3.1e-06 26.2 0.8 1.5 7.5 0.0 4.8 4 1 0 4 4 4 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region Coatomer_WDAD PF04053.14 VDK83551.1 - 0.00019 20.6 0.1 0.0096 15.0 0.1 2.9 3 0 0 3 3 3 1 Coatomer WD associated region Lactonase PF10282.9 VDK83551.1 - 0.00021 20.6 0.1 0.017 14.4 0.0 3.2 4 0 0 4 4 4 1 Lactonase, 7-bladed beta-propeller Ge1_WD40 PF16529.5 VDK83551.1 - 0.0014 17.7 0.9 0.75 8.7 0.0 4.7 4 2 1 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein HPS3_N PF14761.6 VDK83551.1 - 0.0032 17.0 0.0 0.073 12.6 0.0 3.0 3 1 0 3 3 3 1 Hermansky-Pudlak syndrome 3 Gmad1 PF10647.9 VDK83551.1 - 0.013 15.3 0.1 0.86 9.3 0.0 3.2 3 0 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain IKI3 PF04762.12 VDK83551.1 - 0.021 12.9 0.1 0.44 8.5 0.1 2.6 3 0 0 3 3 3 0 IKI3 family Nbas_N PF15492.6 VDK83551.1 - 0.024 14.0 2.5 1.5 8.1 0.0 4.3 4 2 1 5 5 5 0 Neuroblastoma-amplified sequence, N terminal DUF3700 PF12481.8 VDK83551.1 - 0.074 12.5 0.2 5.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Aluminium induced protein TFIIIC_delta PF12657.7 VDK83551.1 - 3.9 7.4 9.1 31 4.4 0.3 4.2 4 2 0 4 4 4 0 Transcription factor IIIC subunit delta N-term Ras PF00071.22 VDK83553.1 - 8.3e-31 106.8 0.0 2.4e-30 105.3 0.0 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 VDK83553.1 - 2.3e-13 50.4 0.0 5.8e-13 49.1 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SOCS_box PF07525.16 VDK83553.1 - 0.00032 21.0 3.5 0.00041 20.7 0.1 2.8 3 0 0 3 3 3 1 SOCS box Arf PF00025.21 VDK83553.1 - 0.03 13.8 0.0 0.046 13.2 0.0 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family NCD2 PF04905.13 VDK83560.1 - 3.7e-53 178.8 0.1 6.1e-53 178.1 0.1 1.4 1 0 0 1 1 1 1 NAB conserved region 2 (NCD2) NCD1 PF04904.13 VDK83560.1 - 4.6e-39 132.3 0.1 5e-38 129.0 0.0 2.3 2 0 0 2 2 2 1 NAB conserved region 1 (NCD1) EMP70 PF02990.16 VDK83561.1 - 0.036 12.7 0.3 0.048 12.3 0.3 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 DUF2207 PF09972.9 VDK83561.1 - 0.062 12.1 1.5 0.71 8.6 1.5 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DHHC PF01529.20 VDK83561.1 - 4.9 7.3 6.2 32 4.6 6.2 2.0 1 1 0 1 1 1 0 DHHC palmitoyltransferase adh_short PF00106.25 VDK83562.1 - 3.1e-28 98.6 0.0 4.1e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK83562.1 - 1.1e-10 41.4 0.0 1.8e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK83562.1 - 1.4e-06 28.4 0.0 1.5e-05 25.0 0.0 2.0 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 VDK83562.1 - 8.1e-05 21.9 0.0 0.00012 21.3 0.0 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 VDK83562.1 - 0.036 13.5 0.0 0.26 10.7 0.0 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Dymeclin PF09742.9 VDK83563.1 - 3.1e-98 329.8 9.8 3.5e-98 329.7 9.8 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 VDK83563.1 - 6.8e-12 44.4 14.5 8.6e-10 37.4 5.1 2.7 2 1 1 3 3 3 2 High-temperature-induced dauer-formation protein DUF3043 PF11241.8 VDK83563.1 - 0.062 13.3 0.2 0.12 12.4 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3043) DUF5411 PF17424.2 VDK83563.1 - 0.089 12.8 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5411) Arf PF00025.21 VDK83576.1 - 1.9e-36 125.2 0.2 2.6e-36 124.7 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 VDK83576.1 - 1.9e-09 37.8 0.0 3e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 VDK83576.1 - 3.2e-09 36.5 0.0 4.4e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 VDK83576.1 - 1.6e-07 30.9 0.4 5.4e-07 29.1 0.4 1.6 1 1 1 2 2 2 1 G-protein alpha subunit Ras PF00071.22 VDK83576.1 - 0.00015 21.4 0.0 0.00023 20.8 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 VDK83576.1 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 VDK83576.1 - 0.002 17.6 0.0 0.0027 17.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GBP PF02263.19 VDK83577.1 - 2.4e-95 318.7 0.0 3.5e-95 318.2 0.0 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 VDK83577.1 - 2.9e-07 30.2 0.1 5.6e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Tiam_CC_Ex PF18385.1 VDK83577.1 - 0.0031 17.9 0.2 0.011 16.1 0.0 2.0 2 0 0 2 2 2 1 T-lymphoma invasion and metastasis CC-Ex domain PalH PF08733.10 VDK83577.1 - 0.043 12.8 0.8 0.069 12.1 0.8 1.3 1 0 0 1 1 1 0 PalH/RIM21 His_Phos_1 PF00300.22 VDK83579.1 - 2.9e-22 79.3 0.0 1.2e-21 77.3 0.0 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) SelK_SelG PF10961.8 VDK83580.1 - 7.9e-12 45.6 11.2 2.5e-10 40.8 11.2 2.1 1 1 0 1 1 1 1 Selenoprotein SelK_SelG EF-hand_7 PF13499.6 VDK83582.1 - 1.5e-08 35.0 1.0 1.5e-08 35.0 1.0 2.7 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK83582.1 - 4.8e-07 29.2 0.1 0.00086 19.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 VDK83582.1 - 5.3e-05 22.5 0.1 0.2 11.3 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 VDK83582.1 - 0.00032 20.5 0.9 0.3 11.0 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK83582.1 - 0.0042 16.5 0.1 2.9 7.5 0.0 3.3 2 0 0 2 2 2 2 EF hand Cir_N PF10197.9 VDK83582.1 - 3.6 7.9 0.0 3.6 7.9 0.0 5.6 5 1 1 6 6 6 0 N-terminal domain of CBF1 interacting co-repressor CIR PRMT5 PF05185.16 VDK83592.1 - 2.6e-56 190.2 0.0 4.4e-56 189.4 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_TIM PF17285.2 VDK83592.1 - 5.9e-30 104.3 0.1 8.3e-30 103.8 0.1 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain ATP-synt_ab PF00006.25 VDK83594.1 - 6.6e-61 205.7 0.0 1.1e-60 204.9 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain LRR_6 PF13516.6 VDK83594.1 - 1.4e-20 71.5 24.6 0.11 12.6 0.0 13.4 14 0 0 14 14 14 6 Leucine Rich repeat ATP-synt_ab_N PF02874.23 VDK83594.1 - 1.9e-20 73.1 1.9 1.9e-20 73.1 1.9 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain LRR_4 PF12799.7 VDK83594.1 - 2.7e-10 40.3 23.1 0.75 10.3 0.1 8.7 7 2 2 9 9 9 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 VDK83594.1 - 6.4e-06 25.8 32.2 0.22 11.3 1.7 9.0 5 5 1 6 6 6 3 Leucine rich repeat LRR_1 PF00560.33 VDK83594.1 - 2.2e-05 24.4 10.8 39 5.3 0.1 10.3 11 0 0 11 11 11 0 Leucine Rich Repeat RsgA_GTPase PF03193.16 VDK83594.1 - 0.0076 16.2 0.1 0.02 14.8 0.1 1.7 1 0 0 1 1 1 1 RsgA GTPase NB-ARC PF00931.22 VDK83594.1 - 0.045 12.9 0.5 0.13 11.4 0.2 1.9 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 VDK83594.1 - 0.051 13.5 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TBD PF12845.7 VDK83594.1 - 0.15 11.9 0.0 0.45 10.4 0.0 1.8 1 0 0 1 1 1 0 TBD domain ATPase PF06745.13 VDK83594.1 - 0.94 8.8 3.8 0.92 8.8 0.2 2.7 3 0 0 3 3 3 0 KaiC R3H PF01424.22 VDK83596.1 - 1.3e-17 63.5 0.1 2.8e-17 62.5 0.1 1.6 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 VDK83596.1 - 9e-07 28.8 29.9 2.9e-05 24.0 10.0 13.1 12 3 1 13 13 13 3 NF-X1 type zinc finger Sec1 PF00995.23 VDK83597.1 - 8.5e-66 223.4 0.3 1.7e-65 222.4 0.1 1.5 2 0 0 2 2 2 1 Sec1 family zf-RING_2 PF13639.6 VDK83605.1 - 8.8e-06 26.0 5.8 8.8e-06 26.0 5.8 2.5 2 1 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 VDK83605.1 - 5.6e-05 22.8 1.0 5.6e-05 22.8 1.0 2.1 2 0 0 2 2 2 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 VDK83605.1 - 7.7e-05 22.2 3.6 7.7e-05 22.2 3.6 2.6 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 VDK83605.1 - 0.0002 21.6 4.1 0.0002 21.6 4.1 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 VDK83605.1 - 0.0012 18.9 2.4 0.0012 18.9 2.4 2.6 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 VDK83605.1 - 0.0017 18.2 3.4 0.0017 18.2 3.4 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK83605.1 - 0.11 12.6 8.7 0.19 11.8 8.1 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-B_box PF00643.24 VDK83605.1 - 0.14 12.3 18.9 0.19 11.9 10.0 3.1 3 0 0 3 3 3 0 B-box zinc finger SPT_ssu-like PF11779.8 VDK83606.1 - 2.5e-12 46.2 1.7 2.5e-12 46.2 1.7 1.8 2 0 0 2 2 2 1 Small subunit of serine palmitoyltransferase-like APG12 PF04110.13 VDK83607.1 - 2.7e-31 107.8 0.0 3e-31 107.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 VDK83607.1 - 1.3e-06 28.5 0.0 1.5e-06 28.3 0.0 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Rft-1 PF04506.13 VDK83608.1 - 3.1e-46 158.2 29.1 1.5e-17 63.5 7.7 3.0 2 1 1 3 3 3 3 Rft protein THUMP PF02926.17 VDK83609.1 - 2.8e-09 37.2 0.0 1.5e-08 34.9 0.0 2.0 1 1 1 2 2 2 1 THUMP domain Kelch_1 PF01344.25 VDK83610.1 - 1.1e-78 258.6 14.8 9.4e-17 60.3 0.7 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 VDK83610.1 - 2.1e-44 148.4 3.8 5.3e-07 29.7 0.0 6.5 3 2 3 6 6 6 6 Kelch motif BTB PF00651.31 VDK83610.1 - 7e-28 97.1 0.8 1.2e-27 96.3 0.8 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 VDK83610.1 - 1.1e-26 92.9 0.4 2.1e-26 92.0 0.2 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_2 PF07646.15 VDK83610.1 - 8.7e-26 88.9 5.7 4.4e-07 29.6 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 VDK83610.1 - 2.5e-24 85.0 5.5 2.1e-05 24.4 0.0 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 VDK83610.1 - 2.2e-18 66.0 11.9 0.0047 17.2 0.2 6.4 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 VDK83610.1 - 0.0002 21.3 8.1 6.1 7.0 0.0 5.5 6 0 0 6 6 6 3 Kelch motif DUF3342 PF11822.8 VDK83610.1 - 0.023 14.9 0.4 0.16 12.2 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3342) Pro_isomerase PF00160.21 VDK83611.1 - 6.8e-47 159.7 0.4 1.3e-46 158.8 0.4 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SF1-HH PF16275.5 VDK83611.1 - 2.5e-34 118.0 0.5 2.5e-34 118.0 0.5 2.1 2 0 0 2 2 1 1 Splicing factor 1 helix-hairpin domain RRM_1 PF00076.22 VDK83611.1 - 4.8e-19 68.0 0.0 9.7e-19 67.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 PF00013.29 VDK83611.1 - 2.1e-07 30.7 0.1 4.9e-07 29.5 0.1 1.6 1 0 0 1 1 1 1 KH domain zf-CCHC_3 PF13917.6 VDK83611.1 - 6e-05 22.9 3.4 0.027 14.4 0.5 2.7 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 VDK83611.1 - 0.00025 21.0 9.3 0.00044 20.2 1.1 2.6 2 0 0 2 2 2 1 Zinc knuckle Presenilin PF01080.17 VDK83611.1 - 0.0079 15.0 10.0 0.012 14.4 10.0 1.2 1 0 0 1 1 1 1 Presenilin Apt1 PF10351.9 VDK83611.1 - 0.013 14.4 14.8 0.018 13.9 14.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 VDK83611.1 - 0.33 9.5 10.8 0.42 9.1 10.8 1.1 1 0 0 1 1 1 0 Macoilin family zf-CCHC_4 PF14392.6 VDK83611.1 - 2.8 7.8 4.6 2.6 7.8 0.8 2.4 2 0 0 2 2 2 0 Zinc knuckle DUF4551 PF15087.6 VDK83611.1 - 6.2 5.5 11.8 8.8 5.0 11.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF4618 PF15397.6 VDK83620.1 - 0.0044 16.5 9.8 0.019 14.4 9.6 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4618) ZapB PF06005.12 VDK83620.1 - 0.008 16.6 2.2 2.8 8.4 0.1 3.5 3 2 0 3 3 3 1 Cell division protein ZapB Phage_TAC_8 PF10666.9 VDK83620.1 - 0.11 12.7 3.4 0.31 11.3 1.6 2.4 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Gp14 ()A118 TRPM_tetra PF16519.5 VDK83620.1 - 2.6 8.2 6.5 5.7 7.1 0.0 4.0 4 1 1 5 5 5 0 Tetramerisation domain of TRPM DUF1664 PF07889.12 VDK83620.1 - 2.8 8.0 8.2 0.75 9.8 0.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) 7tm_1 PF00001.21 VDK83621.1 - 3.1e-35 121.8 19.8 4.3e-35 121.3 19.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK83621.1 - 8.6e-05 22.0 20.7 0.00028 20.3 14.4 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 VDK83621.1 - 0.0004 20.1 15.1 0.0004 20.1 15.1 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx DUF4635 PF15466.6 VDK83621.1 - 0.13 11.8 0.1 0.24 10.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) DUF962 PF06127.11 VDK83621.1 - 1 9.5 7.2 5.4 7.2 3.6 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Cadherin PF00028.17 VDK83623.1 - 7.4e-53 177.0 6.2 1.4e-10 41.4 0.2 8.7 8 1 0 8 8 8 8 Cadherin domain Cadherin_3 PF16184.5 VDK83623.1 - 0.017 15.1 7.1 16 5.5 0.0 5.5 5 1 0 5 5 5 0 Cadherin-like RhoGEF PF00621.20 VDK83631.1 - 1.1e-19 71.3 4.3 1.1e-19 71.3 4.3 3.1 2 1 1 3 3 3 1 RhoGEF domain PH_16 PF17838.1 VDK83631.1 - 2.7e-09 36.9 0.0 9.8e-09 35.1 0.0 1.9 1 0 0 1 1 1 1 PH domain Cwf_Cwc_15 PF04889.12 VDK83632.1 - 5.7 6.6 10.6 6.2 6.5 10.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4191 PF13829.6 VDK83633.1 - 8.8 5.6 12.5 10 5.4 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Baculo_F PF12259.8 VDK83633.1 - 9.5 4.6 12.1 11 4.4 12.1 1.1 1 0 0 1 1 1 0 Baculovirus F protein Golgin_A5 PF09787.9 VDK83645.1 - 6.6e-30 104.6 53.3 2e-16 60.4 7.0 3.2 2 1 1 3 3 3 2 Golgin subfamily A member 5 Bacillus_HBL PF05791.11 VDK83645.1 - 0.0077 16.1 9.6 0.0077 16.1 9.6 3.6 1 1 3 4 4 4 2 Bacillus haemolytic enterotoxin (HBL) DUF1843 PF08898.10 VDK83645.1 - 0.03 14.8 3.9 3.6 8.2 0.4 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) CENP-F_N PF10481.9 VDK83645.1 - 0.062 12.9 45.7 0.76 9.4 3.0 3.3 2 2 1 3 3 3 0 Cenp-F N-terminal domain Img2 PF05046.14 VDK83645.1 - 1.5 9.2 4.1 7.6 6.9 1.0 3.1 2 1 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) ATG16 PF08614.11 VDK83645.1 - 4 7.6 59.1 1.9 8.7 7.3 3.8 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 VDK83645.1 - 9.5 6.3 31.4 2.6 8.1 0.4 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Vta1 PF04652.16 VDK83647.1 - 6.5e-47 159.1 1.6 1e-46 158.5 0.6 1.8 2 0 0 2 2 2 1 Vta1 like RhoGAP PF00620.27 VDK83647.1 - 8.5e-29 100.3 2.0 1.4e-28 99.7 0.4 2.2 3 0 0 3 3 3 1 RhoGAP domain Vta1_C PF18097.1 VDK83647.1 - 6.8e-10 38.5 2.5 6.8e-10 38.5 2.5 2.0 2 0 0 2 2 2 1 Vta1 C-terminal domain LRR_8 PF13855.6 VDK83649.1 - 7.6e-42 140.9 57.2 3e-11 42.9 10.1 6.1 3 1 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 VDK83649.1 - 4.7e-16 58.6 44.7 1.9e-06 28.1 2.1 6.7 4 1 3 7 7 7 7 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 VDK83649.1 - 3.2e-15 56.2 4.5 5.6e-07 29.6 0.0 3.9 3 1 1 4 4 4 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 VDK83649.1 - 4.5e-08 32.6 40.2 0.25 12.0 0.1 11.4 12 0 0 12 12 12 4 Leucine Rich Repeat LRR_6 PF13516.6 VDK83649.1 - 0.15 12.2 36.5 7.8 6.8 0.3 10.3 11 0 0 11 11 11 0 Leucine Rich repeat COMMD1_N PF17221.3 VDK83651.1 - 0.0017 18.6 2.4 0.13 12.6 0.3 2.1 1 1 1 2 2 2 2 COMMD1 N-terminal domain Auts2 PF15336.6 VDK83651.1 - 2.2 8.4 4.0 3 7.9 4.0 1.2 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein polyprenyl_synt PF00348.17 VDK83653.1 - 2.1e-73 246.6 0.3 2.6e-73 246.3 0.3 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Peptidase_S9 PF00326.21 VDK83654.1 - 9.9e-49 165.7 0.0 1.5e-48 165.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.21 VDK83654.1 - 1.5e-45 155.5 0.0 2.3e-45 154.9 0.0 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DLH PF01738.18 VDK83654.1 - 2.8e-07 30.3 0.0 6.7e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 VDK83654.1 - 2.2e-05 25.2 0.6 0.00039 21.1 0.2 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 VDK83654.1 - 2.6e-05 24.0 0.1 0.00027 20.6 0.2 2.3 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 VDK83654.1 - 0.00028 20.2 0.0 0.0017 17.7 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK83654.1 - 0.00047 19.9 0.0 0.00088 19.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 VDK83654.1 - 0.0075 15.9 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase AXE1 PF05448.12 VDK83654.1 - 0.026 13.2 0.3 0.42 9.2 0.0 2.3 2 1 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF2920 PF11144.8 VDK83654.1 - 0.036 13.3 0.0 0.059 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Abhydrolase_2 PF02230.16 VDK83654.1 - 0.074 12.9 0.0 13 5.5 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 VDK83654.1 - 0.13 12.0 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold SCAPER_N PF16501.5 VDK83655.1 - 6.2e-22 77.5 0.4 3.9e-21 74.9 0.4 2.4 1 0 0 1 1 1 1 S phase cyclin A-associated protein in the endoplasmic reticulum Stathmin PF00836.19 VDK83655.1 - 0.00019 21.4 26.4 0.00019 21.4 26.4 4.7 5 1 0 5 5 5 1 Stathmin family DUF4177 PF13783.6 VDK83655.1 - 0.025 14.9 0.0 0.093 13.0 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) Pkinase PF00069.25 VDK83672.1 - 1.7e-67 227.6 0.0 2e-67 227.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK83672.1 - 7.4e-44 150.0 0.0 8.8e-44 149.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 VDK83672.1 - 0.0047 16.6 0.1 0.031 13.9 0.0 2.2 3 0 0 3 3 3 1 RIO1 family Haspin_kinase PF12330.8 VDK83672.1 - 0.0059 15.6 0.0 0.0096 14.9 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 VDK83672.1 - 0.01 15.2 0.0 0.15 11.3 0.0 2.4 2 1 0 2 2 2 0 Kinase-like YrbL-PhoP_reg PF10707.9 VDK83672.1 - 0.053 13.0 0.1 0.1 12.1 0.1 1.6 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL MADF_DNA_bdg PF10545.9 VDK83673.1 - 1e-15 57.8 0.1 1.5e-15 57.3 0.1 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK83673.1 - 6.2e-09 36.1 0.1 9e-09 35.6 0.1 1.3 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-binding PF00249.31 VDK83673.1 - 0.87 9.8 3.9 2.3 8.5 3.9 1.8 1 1 0 1 1 1 0 Myb-like DNA-binding domain KH_1 PF00013.29 VDK83674.1 - 4.8e-41 138.4 15.1 3.4e-16 58.8 2.5 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 VDK83674.1 - 8.6e-16 57.5 10.6 1.9e-06 27.6 0.2 3.3 2 1 1 3 3 3 3 KH domain KH_5 PF13184.6 VDK83674.1 - 3.5e-07 30.2 6.8 0.034 14.2 0.2 3.5 3 0 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 VDK83674.1 - 2.5e-06 27.2 4.4 0.074 12.9 0.1 3.6 3 0 0 3 3 3 3 KH domain zf_CCCH_4 PF18345.1 VDK83675.1 - 5e-08 32.7 4.5 9.9e-08 31.8 4.5 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 VDK83675.1 - 4.3e-07 29.7 1.4 8e-07 28.8 1.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 VDK83675.1 - 2.8e-05 24.8 0.9 5.4e-05 23.8 0.4 1.8 1 1 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 VDK83675.1 - 0.00033 20.4 4.3 0.00058 19.6 4.3 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger EutB PF06751.11 VDK83675.1 - 0.017 14.0 0.1 0.023 13.5 0.1 1.1 1 0 0 1 1 1 0 Ethanolamine ammonia lyase large subunit (EutB) zf-CCCH_2 PF14608.6 VDK83675.1 - 0.05 14.1 5.6 0.17 12.4 5.6 1.9 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF3990 PF13151.6 VDK83675.1 - 0.05 13.3 0.5 0.089 12.5 0.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3990) HeH PF12949.7 VDK83675.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 1 0 0 1 1 1 0 HeH/LEM domain Fer2_3 PF13085.6 VDK83675.1 - 0.14 12.2 1.1 0.46 10.5 1.1 1.8 1 1 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain AAA_28 PF13521.6 VDK83679.1 - 2e-20 73.7 0.1 3.6e-20 72.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 VDK83679.1 - 0.0083 15.8 0.0 0.022 14.4 0.0 1.6 1 1 0 1 1 1 1 Thymidylate kinase KTI12 PF08433.10 VDK83679.1 - 0.0095 15.4 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Myosin_head PF00063.21 VDK83680.1 - 8.6e-209 695.1 5.4 1.1e-208 694.8 5.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 VDK83680.1 - 3.9e-41 140.8 0.2 6.5e-41 140.1 0.2 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 VDK83680.1 - 3.5e-16 58.5 0.1 6.4e-16 57.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK83680.1 - 4.7e-15 55.2 0.1 1.1e-14 54.0 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK83680.1 - 7e-11 41.6 0.0 1.5e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_22 PF13401.6 VDK83680.1 - 0.018 15.3 0.1 0.95 9.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 VDK83680.1 - 0.03 14.7 0.0 0.15 12.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain NAD_kinase PF01513.21 VDK83686.1 - 3.1e-07 29.9 0.0 6.5e-07 28.8 0.0 1.5 2 0 0 2 2 2 1 ATP-NAD kinase MSV199 PF10553.9 VDK83686.1 - 0.14 12.4 0.2 2.2 8.5 0.1 2.1 2 0 0 2 2 2 0 MSV199 domain m_DGTX_Dc1a_b_c PF17491.2 VDK83688.1 - 0.0065 17.1 0.7 3.7 8.3 0.3 2.6 2 0 0 2 2 2 2 Spider Toxins mu-diguetoxin-1 a, b and c DUF1041 PF06292.17 VDK83689.1 - 1.8e-24 86.2 0.5 1.8e-24 86.2 0.5 2.7 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1041) PH PF00169.29 VDK83689.1 - 4e-07 30.5 1.7 1.3e-06 28.9 0.1 2.5 2 0 0 2 2 2 1 PH domain HTH_Tnp_4 PF13613.6 VDK83691.1 - 0.054 13.2 0.3 0.16 11.7 0.3 1.8 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease Ibs_toxin PF13956.6 VDK83691.1 - 0.12 12.4 7.1 0.69 10.0 7.1 2.4 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system HMG_box PF00505.19 VDK83695.1 - 8.6e-27 93.4 2.0 1.6e-26 92.5 2.0 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK83695.1 - 8.3e-10 39.1 1.2 1.7e-09 38.1 1.2 1.5 1 0 0 1 1 1 1 HMG-box domain Ribosomal_60s PF00428.19 VDK83695.1 - 0.021 15.4 3.9 0.021 15.4 3.9 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein Shadoo PF14999.6 VDK83695.1 - 0.024 14.7 3.5 0.024 14.7 3.5 2.2 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective DUF4148 PF13663.6 VDK83695.1 - 0.2 11.9 9.5 0.34 11.1 1.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) K_channel_TID PF07941.11 VDK83695.1 - 0.35 11.4 18.5 0.28 11.7 8.5 2.5 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Nnf1 PF03980.14 VDK83702.1 - 0.0026 18.1 0.1 0.006 16.9 0.0 1.7 2 1 0 2 2 2 1 Nnf1 CPL PF08144.11 VDK83702.1 - 0.014 15.7 1.0 0.02 15.3 1.0 1.2 1 0 0 1 1 1 0 CPL (NUC119) domain FHIPEP PF00771.20 VDK83702.1 - 0.036 12.5 0.2 0.048 12.1 0.2 1.1 1 0 0 1 1 1 0 FHIPEP family MIR PF02815.19 VDK83702.1 - 0.065 13.1 0.0 0.099 12.5 0.0 1.3 1 0 0 1 1 1 0 MIR domain UT PF03253.14 VDK83702.1 - 0.24 10.5 0.0 0.3 10.2 0.0 1.1 1 0 0 1 1 1 0 Urea transporter Rhomboid PF01694.22 VDK83703.1 - 3.4e-34 118.0 7.7 3.4e-34 118.0 7.7 1.9 3 0 0 3 3 3 1 Rhomboid family EF-hand_7 PF13499.6 VDK83703.1 - 1.7e-11 44.4 0.6 2.7e-11 43.7 0.6 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 VDK83703.1 - 1.4e-07 31.2 0.1 0.017 14.9 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK83703.1 - 7.7e-07 28.2 0.2 0.057 13.0 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 VDK83703.1 - 3.6e-05 23.3 1.3 0.043 13.7 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 VDK83703.1 - 0.001 18.5 1.8 0.06 12.9 0.2 2.4 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 VDK83703.1 - 0.012 16.0 0.1 0.021 15.1 0.1 1.5 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region PDZ PF00595.24 VDK83704.1 - 4.6e-18 65.4 0.0 6.1e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK83704.1 - 1.1e-08 34.8 0.0 1.9e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK83704.1 - 2.4e-07 31.0 0.0 3.1e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PFK PF00365.20 VDK83705.1 - 1e-191 635.3 1.8 1.6e-106 355.8 1.1 2.5 2 0 0 2 2 2 2 Phosphofructokinase ABC_tran PF00005.27 VDK83705.1 - 1.5e-42 145.4 0.0 4.9e-27 95.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 VDK83705.1 - 6.3e-31 107.7 55.9 1.3e-17 64.0 16.2 3.6 2 2 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 VDK83705.1 - 7.4e-13 49.0 5.5 3.6e-06 27.0 0.0 3.7 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 VDK83705.1 - 1.3e-05 24.8 0.2 0.021 14.2 0.0 3.1 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 VDK83705.1 - 2.9e-05 24.7 1.7 0.075 13.5 0.0 3.2 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 VDK83705.1 - 0.00012 22.1 1.8 0.011 15.6 0.0 2.9 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 VDK83705.1 - 0.0012 18.5 2.2 0.086 12.6 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 VDK83705.1 - 0.018 14.4 0.1 0.29 10.4 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_27 PF13514.6 VDK83705.1 - 0.085 12.4 0.2 16 5.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 VDK83705.1 - 0.089 13.3 0.0 3.6 8.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 VDK83705.1 - 0.092 12.8 0.1 14 5.8 0.1 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_15 PF13175.6 VDK83705.1 - 0.094 12.4 4.3 0.14 11.8 0.0 3.0 3 1 0 3 3 3 0 AAA ATPase domain DLIC PF05783.11 VDK83705.1 - 0.16 10.8 1.2 0.37 9.6 0.0 2.1 3 0 0 3 3 3 0 Dynein light intermediate chain (DLIC) AAA_30 PF13604.6 VDK83705.1 - 0.36 10.5 0.8 4.1 7.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain Kinesin PF00225.23 VDK83706.1 - 3.6e-90 302.3 0.3 3.6e-90 302.3 0.3 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 VDK83706.1 - 1.4e-24 86.8 0.1 1.4e-24 86.8 0.1 2.9 3 0 0 3 3 3 1 Microtubule binding AAA_21 PF13304.6 VDK83706.1 - 1.9e-07 31.2 0.1 8.5e-07 29.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Fib_alpha PF08702.10 VDK83706.1 - 0.0038 17.4 8.5 0.0038 17.4 8.5 2.8 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family ABC_tran PF00005.27 VDK83706.1 - 0.0048 17.4 0.0 0.0048 17.4 0.0 3.5 3 1 0 3 3 3 1 ABC transporter Cnn_1N PF07989.11 VDK83706.1 - 0.35 11.1 18.5 2 8.6 9.3 3.3 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 zf-C4H2 PF10146.9 VDK83706.1 - 0.44 10.8 20.9 0.39 11.0 11.3 3.0 3 0 0 3 3 3 0 Zinc finger-containing protein ATG16 PF08614.11 VDK83706.1 - 0.89 9.7 24.4 0.57 10.4 12.9 3.0 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) UPF0242 PF06785.11 VDK83706.1 - 7.4 6.6 24.4 0.022 14.9 8.8 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus PP2C PF00481.21 VDK83715.1 - 6.5e-55 186.5 0.0 1.1e-54 185.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 VDK83715.1 - 0.091 12.4 0.0 0.4 10.3 0.1 2.0 2 1 0 2 2 2 0 Protein phosphatase 2C Kelch_4 PF13418.6 VDK83716.1 - 1.1e-32 111.8 1.2 9e-11 41.6 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 VDK83716.1 - 4.4e-23 81.0 0.3 8.7e-05 22.7 0.0 6.0 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 VDK83716.1 - 1.9e-21 75.6 9.1 1.8e-07 30.9 0.0 6.5 6 1 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 VDK83716.1 - 5.7e-20 70.6 7.2 2.7e-07 30.1 0.7 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 VDK83716.1 - 2.8e-17 62.3 8.9 7.2e-06 26.1 0.8 5.8 4 1 2 6 6 6 3 Kelch motif Kelch_2 PF07646.15 VDK83716.1 - 5.3e-13 48.4 9.7 0.00059 19.7 0.5 5.8 5 0 0 5 5 5 3 Kelch motif F-box-like PF12937.7 VDK83716.1 - 1.1e-07 31.7 0.8 5.5e-07 29.4 0.0 2.4 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 VDK83716.1 - 0.00077 19.0 0.1 0.0014 18.1 0.1 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 VDK83716.1 - 0.0009 19.1 0.0 0.0024 17.7 0.0 1.7 1 0 0 1 1 1 1 F-box domain Cofilin_ADF PF00241.20 VDK83717.1 - 3e-24 85.1 0.0 3.5e-24 84.9 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein EF-hand_1 PF00036.32 VDK83718.1 - 8.6e-21 71.9 8.3 0.0077 15.7 0.0 8.2 8 0 0 8 8 8 7 EF hand EF-hand_6 PF13405.6 VDK83718.1 - 4.2e-15 54.3 9.8 0.21 11.6 0.0 8.5 8 0 0 8 8 8 5 EF-hand domain EF-hand_7 PF13499.6 VDK83718.1 - 5.3e-13 49.2 15.9 6.8e-05 23.2 0.3 6.6 3 2 2 5 5 5 4 EF-hand domain pair EF-hand_5 PF13202.6 VDK83718.1 - 7.5e-11 41.0 9.9 0.087 12.4 0.0 7.2 7 0 0 7 7 7 4 EF hand EF-hand_8 PF13833.6 VDK83718.1 - 4.1e-07 29.7 2.4 0.034 14.0 0.2 4.6 3 1 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 VDK83718.1 - 4.2e-06 27.1 8.8 0.055 13.8 0.2 5.8 3 2 2 5 5 5 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 VDK83718.1 - 0.033 14.1 0.1 3.8 7.5 0.0 3.8 4 0 0 4 4 4 0 EF hand CNDH2_N PF06278.11 VDK83718.1 - 0.41 10.9 0.0 0.41 10.9 0.0 4.8 4 0 0 4 4 4 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal NAD_binding_7 PF13241.6 VDK83719.1 - 0.012 16.0 0.8 0.033 14.6 0.1 1.9 2 1 0 2 2 2 0 Putative NAD(P)-binding DUF4058 PF13267.6 VDK83719.1 - 0.2 11.0 3.6 0.3 10.5 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) CHCH PF06747.13 VDK83722.1 - 1.9e-07 31.0 6.8 3.4e-07 30.2 6.8 1.4 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.9 VDK83722.1 - 7.4e-06 26.2 4.9 8.1e-06 26.1 4.9 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) PBD PF00786.28 VDK83728.1 - 9.2e-12 45.1 0.0 1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 P21-Rho-binding domain 7TM_GPCR_Srab PF10292.9 VDK83729.1 - 9.7e-07 28.0 4.9 1.2e-06 27.7 4.9 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR receptor class ab chemoreceptor Sre PF03125.18 VDK83729.1 - 0.0001 21.6 3.3 0.00015 21.1 3.3 1.3 1 0 0 1 1 1 1 C. elegans Sre G protein-coupled chemoreceptor DUF4271 PF14093.6 VDK83729.1 - 0.0036 17.3 7.2 0.0064 16.4 7.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4271) PMP22_Claudin PF00822.20 VDK83729.1 - 0.025 14.5 2.5 0.045 13.6 2.5 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Cys_knot PF00007.22 VDK83730.1 - 5.1e-08 33.2 4.6 9.1e-08 32.3 4.6 1.3 1 0 0 1 1 1 1 Cystine-knot domain 7tm_1 PF00001.21 VDK83731.1 - 9.5e-17 61.2 0.1 9.5e-17 61.2 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK83731.1 - 0.00094 18.6 1.2 0.0013 18.2 1.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srv PF10323.9 VDK83731.1 - 0.0026 17.2 1.4 0.0035 16.8 1.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv IF-2B PF01008.17 VDK83733.1 - 3.9e-65 219.9 0.1 4.8e-65 219.6 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family ThiG PF05690.14 VDK83733.1 - 0.13 11.5 0.3 0.23 10.7 0.3 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG SWIB PF02201.18 VDK83735.1 - 9.4e-19 67.1 0.0 2e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 VDK83735.1 - 3.4e-07 30.1 2.2 6.2e-07 29.3 2.2 1.5 1 0 0 1 1 1 1 DEK C terminal domain CCDC71L PF15374.6 VDK83735.1 - 0.023 14.0 5.9 0.032 13.5 5.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Tox-ART-HYD1 PF15633.6 VDK83735.1 - 0.028 15.1 0.5 0.064 13.9 0.4 1.7 1 1 0 1 1 1 0 HYD1 signature containing ADP-ribosyltransferase RcsD_ABL PF16359.5 VDK83735.1 - 0.034 14.3 0.3 0.074 13.2 0.3 1.6 1 0 0 1 1 1 0 RcsD-ABL domain DUF2766 PF10964.8 VDK83735.1 - 0.054 13.5 0.2 0.11 12.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2766) Ion_trans PF00520.31 VDK83736.1 - 5e-16 58.7 1.3 7.1e-16 58.2 1.3 1.2 1 0 0 1 1 1 1 Ion transport protein cNMP_binding PF00027.29 VDK83736.1 - 1.1e-13 51.0 0.0 6.2e-13 48.6 0.0 2.2 3 0 0 3 3 3 1 Cyclic nucleotide-binding domain Ion_trans_2 PF07885.16 VDK83736.1 - 1.9e-10 40.6 2.4 1.9e-10 40.6 2.4 1.9 2 0 0 2 2 2 1 Ion channel IRK PF01007.20 VDK83736.1 - 2.6 7.8 8.4 24 4.7 8.4 2.0 1 1 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain Ion_trans PF00520.31 VDK83737.1 - 6.7e-15 55.0 3.4 8.1e-15 54.7 3.4 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 VDK83737.1 - 0.051 12.2 0.6 0.062 12.0 0.6 1.1 1 0 0 1 1 1 0 Polycystin cation channel I-set PF07679.16 VDK83743.1 - 1.5e-103 339.1 1.0 1.5e-16 60.2 0.0 8.4 8 0 0 8 8 8 8 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK83743.1 - 3.4e-97 319.2 12.4 8.5e-16 58.3 0.0 8.5 8 0 0 8 8 8 8 Immunoglobulin domain Ig_2 PF13895.6 VDK83743.1 - 8.5e-74 243.9 9.6 3.6e-10 40.0 0.0 8.3 7 1 1 8 8 8 7 Immunoglobulin domain ig PF00047.25 VDK83743.1 - 2.4e-59 197.5 8.4 9.6e-08 32.1 0.0 9.2 8 1 0 8 8 8 8 Immunoglobulin domain V-set PF07686.17 VDK83743.1 - 1.8e-26 92.4 17.6 0.00019 21.6 0.1 13.3 8 7 3 11 11 11 6 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK83743.1 - 6.1e-24 83.9 7.0 6.7e-05 22.9 0.0 7.0 6 0 0 6 6 6 4 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 VDK83743.1 - 6.3e-19 68.2 0.0 0.0057 17.0 0.0 8.0 8 1 0 8 8 8 5 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 VDK83743.1 - 1.8e-17 63.4 0.8 0.32 11.3 0.0 8.5 8 1 0 8 8 8 4 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 VDK83743.1 - 2.8e-15 55.6 0.0 0.025 14.1 0.0 7.0 7 0 0 7 7 7 3 Immunoglobulin domain Izumo-Ig PF16706.5 VDK83743.1 - 7.4e-12 45.2 1.4 0.0031 17.5 0.0 7.3 8 0 0 8 8 8 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 VDK83743.1 - 6.8e-11 42.1 0.8 0.13 12.3 0.0 7.1 7 2 0 7 7 7 3 C17orf99 Ig domain BiPBP_C PF06832.12 VDK83743.1 - 3.3e-05 23.9 0.0 6.5 6.9 0.0 5.8 5 2 1 6 6 6 1 Penicillin-Binding Protein C-terminus Family V-set_CD47 PF08204.11 VDK83743.1 - 0.00019 21.4 5.8 11 6.0 0.0 6.5 7 1 0 7 7 6 1 CD47 immunoglobulin-like domain C2-set PF05790.15 VDK83743.1 - 0.0016 18.5 1.2 25 5.1 0.0 5.5 6 0 0 6 6 5 0 Immunoglobulin C2-set domain Big_6 PF17936.1 VDK83743.1 - 0.16 12.2 0.5 23 5.3 0.0 3.6 3 0 0 3 3 3 0 Bacterial Ig domain Y_phosphatase PF00102.27 VDK83745.1 - 3.8e-60 203.4 0.2 7.5e-60 202.4 0.2 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase IRS PF02174.17 VDK83745.1 - 0.00058 19.7 0.0 0.0025 17.6 0.0 2.2 1 0 0 1 1 1 1 PTB domain (IRS-1 type) PH PF00169.29 VDK83745.1 - 0.0076 16.7 0.0 0.026 15.0 0.0 1.9 1 0 0 1 1 1 1 PH domain DSPc PF00782.20 VDK83745.1 - 0.017 14.9 0.2 0.069 13.0 0.1 2.0 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK83745.1 - 0.097 12.6 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family MADF_DNA_bdg PF10545.9 VDK83758.1 - 5.5e-18 65.1 0.1 1.1e-17 64.1 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK83758.1 - 2.7e-05 24.5 0.0 5.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 VDK83758.1 - 0.0012 18.9 0.5 0.0025 17.8 0.5 1.5 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain HLH PF00010.26 VDK83759.1 - 8.7e-11 41.6 4.0 1.6e-10 40.8 4.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Reprolysin PF01421.19 VDK83760.1 - 1.2e-09 38.4 0.1 3.7e-09 36.8 0.1 1.8 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 VDK83760.1 - 6.9e-06 26.6 1.0 2.3e-05 24.9 0.4 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 VDK83760.1 - 4.3e-05 23.8 1.7 7.5e-05 23.0 0.0 2.1 3 0 0 3 3 3 1 Metallo-peptidase family M12 MOZ_SAS PF01853.18 VDK83762.1 - 3.1e-78 261.6 0.0 4.6e-78 261.0 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 VDK83762.1 - 1.9e-20 72.2 5.4 3.8e-20 71.2 5.4 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 VDK83762.1 - 2.8e-12 46.3 0.2 1.6e-11 43.9 0.2 2.3 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 VDK83762.1 - 0.00033 21.0 0.0 0.0007 20.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TLE_N PF03920.15 VDK83762.1 - 0.0076 16.3 0.1 0.02 15.0 0.1 1.7 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain Acetyltransf_1 PF00583.25 VDK83762.1 - 0.023 14.9 0.0 0.069 13.4 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family ApoO PF09769.9 VDK83763.1 - 1.8e-13 50.6 0.0 2.4e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Apolipoprotein O Cadherin_C_2 PF16492.5 VDK83764.1 - 0.051 14.3 0.9 0.087 13.6 0.0 1.8 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal MyTH4 PF00784.17 VDK83764.1 - 0.16 12.5 0.7 0.77 10.3 0.7 2.2 1 1 0 1 1 1 0 MyTH4 domain Pkinase_Tyr PF07714.17 VDK83777.1 - 3.4e-89 298.5 1.1 1.6e-88 296.4 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase I-set PF07679.16 VDK83777.1 - 1.9e-43 146.4 1.5 4.1e-16 58.8 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK83777.1 - 3.3e-36 123.7 6.9 7.5e-14 52.1 0.1 4.3 4 0 0 4 4 4 3 Immunoglobulin domain Pkinase PF00069.25 VDK83777.1 - 8e-29 100.8 6.2 7.6e-20 71.4 0.0 3.0 3 1 0 3 3 3 2 Protein kinase domain ig PF00047.25 VDK83777.1 - 5.8e-23 80.9 17.7 1.6e-10 41.0 0.1 4.3 5 0 0 5 5 3 3 Immunoglobulin domain Ig_2 PF13895.6 VDK83777.1 - 1.9e-21 76.2 1.4 1.5e-07 31.6 0.0 4.4 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 VDK83777.1 - 6.2e-15 55.3 12.7 1.4e-05 25.2 0.3 4.9 4 2 0 4 4 3 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK83777.1 - 4.3e-08 33.1 0.2 0.023 14.8 0.0 3.8 3 0 0 3 3 3 2 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 VDK83777.1 - 1.4e-06 27.7 0.0 0.59 9.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain Izumo-Ig PF16706.5 VDK83777.1 - 0.00074 19.5 0.1 2.4 8.3 0.0 3.5 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 VDK83777.1 - 0.0041 17.3 0.0 5.3 7.3 0.0 3.1 2 0 0 2 2 2 2 Natural killer cell receptor 2B4 V-set_CD47 PF08204.11 VDK83777.1 - 0.036 14.0 5.5 1.1 9.2 0.0 2.8 1 1 1 2 2 2 0 CD47 immunoglobulin-like domain Adeno_E3_CR1 PF02440.15 VDK83777.1 - 0.17 11.7 6.2 0.88 9.4 0.1 3.3 3 0 0 3 3 3 0 Adenovirus E3 region protein CR1 Plk4_PB1 PF18190.1 VDK83777.1 - 0.44 10.7 2.9 0.5 10.6 0.7 2.2 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 1 TFIIA PF03153.13 VDK83777.1 - 0.59 10.1 21.9 0.073 13.1 16.0 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit APOBEC_N PF08210.11 VDK83778.1 - 1.4e-21 77.2 2.8 1.4e-21 77.2 2.8 2.4 1 1 1 2 2 2 1 APOBEC-like N-terminal domain TCR PF03638.15 VDK83778.1 - 0.015 15.6 21.6 0.015 15.6 21.6 5.1 3 1 1 4 4 4 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain Rab3-GTPase_cat PF13890.6 VDK83779.1 - 6.3e-50 169.0 0.3 1.2e-49 168.1 0.3 1.5 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit Tub PF01167.18 VDK83785.1 - 1.9e-88 296.3 0.0 2.2e-88 296.1 0.0 1.0 1 0 0 1 1 1 1 Tub family DUF3527 PF12043.8 VDK83785.1 - 0.00089 18.9 0.0 0.0036 16.9 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3527) RE_ScaI PF09569.10 VDK83785.1 - 0.058 13.1 0.0 0.096 12.4 0.0 1.3 1 0 0 1 1 1 0 ScaI restriction endonuclease RNA_pol_Rpb5_C PF01191.19 VDK83787.1 - 5.1e-35 119.2 0.2 5.1e-35 119.2 0.2 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 VDK83787.1 - 2.2e-34 117.9 0.1 4.5e-34 116.9 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain DUF4817 PF16087.5 VDK83787.1 - 0.029 14.2 0.0 0.067 13.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) Mrr_cat PF04471.12 VDK83787.1 - 0.097 12.7 0.0 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 Restriction endonuclease TMEM138 PF14935.6 VDK83790.1 - 8.6e-21 74.8 13.4 8.6e-21 74.8 13.4 1.5 2 0 0 2 2 2 1 Transmembrane protein 138 SPC25 PF06703.11 VDK83790.1 - 3.7 7.3 9.6 0.75 9.6 2.6 2.1 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) AAA PF00004.29 VDK83791.1 - 1.1e-29 103.6 0.0 2.3e-29 102.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK83791.1 - 6.3e-08 33.0 0.0 1.7e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK83791.1 - 2.9e-06 27.8 0.0 1.1e-05 25.8 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 VDK83791.1 - 3.3e-05 24.4 0.0 7.8e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 VDK83791.1 - 4.2e-05 23.4 0.0 7.9e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 VDK83791.1 - 0.00014 21.9 0.0 0.00029 20.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 VDK83791.1 - 0.00025 20.7 0.4 0.2 11.2 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_28 PF13521.6 VDK83791.1 - 0.00027 21.2 0.0 0.00043 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 VDK83791.1 - 0.00027 21.3 0.0 0.00069 20.0 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 VDK83791.1 - 0.00039 20.6 0.0 0.0012 19.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 VDK83791.1 - 0.00075 19.3 0.0 0.0069 16.1 0.0 2.1 1 1 0 2 2 2 1 IstB-like ATP binding protein NACHT PF05729.12 VDK83791.1 - 0.00089 19.2 0.0 0.0021 18.0 0.0 1.7 1 1 0 1 1 1 1 NACHT domain AAA_11 PF13086.6 VDK83791.1 - 0.0015 18.4 0.0 0.0031 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 VDK83791.1 - 0.0019 17.9 0.0 0.0042 16.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 VDK83791.1 - 0.002 18.1 0.0 0.0039 17.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 VDK83791.1 - 0.0021 17.9 0.0 0.004 16.9 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 VDK83791.1 - 0.0022 17.2 0.1 0.026 13.7 0.1 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF815) Cytidylate_kin PF02224.18 VDK83791.1 - 0.0025 17.6 0.0 0.0038 17.0 0.0 1.4 1 0 0 1 1 1 1 Cytidylate kinase TIP49 PF06068.13 VDK83791.1 - 0.0031 16.8 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain Rad17 PF03215.15 VDK83791.1 - 0.0036 17.3 0.1 0.014 15.3 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain SpmSyn_N PF17950.1 VDK83791.1 - 0.0045 17.1 0.0 1.5 9.1 0.0 3.8 3 0 0 3 3 3 1 S-adenosylmethionine decarboxylase N -terminal AAA_17 PF13207.6 VDK83791.1 - 0.0064 16.9 0.0 0.017 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 VDK83791.1 - 0.0066 15.8 0.4 0.3 10.4 0.2 2.4 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region AAA_19 PF13245.6 VDK83791.1 - 0.011 16.0 0.1 0.073 13.4 0.1 2.3 2 1 0 2 2 1 0 AAA domain AAA_30 PF13604.6 VDK83791.1 - 0.012 15.3 0.0 0.027 14.2 0.0 1.5 2 0 0 2 2 1 0 AAA domain DnaB_C PF03796.15 VDK83791.1 - 0.012 14.9 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_5 PF07728.14 VDK83791.1 - 0.013 15.5 0.3 0.035 14.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 VDK83791.1 - 0.018 14.4 0.0 1.5 8.1 0.0 2.4 1 1 1 2 2 2 0 KaiC Zot PF05707.12 VDK83791.1 - 0.024 14.3 0.0 0.069 12.8 0.0 1.8 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_7 PF12775.7 VDK83791.1 - 0.033 13.7 0.0 0.069 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ECH_1 PF00378.20 VDK83791.1 - 0.035 13.4 0.0 0.23 10.7 0.0 2.2 3 0 0 3 3 2 0 Enoyl-CoA hydratase/isomerase AAA_3 PF07726.11 VDK83791.1 - 0.041 13.7 0.0 0.091 12.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 VDK83791.1 - 0.047 13.6 0.2 0.5 10.2 0.1 2.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 VDK83791.1 - 0.068 12.4 0.0 13 4.9 0.0 2.4 1 1 1 2 2 2 0 KAP family P-loop domain PduV-EutP PF10662.9 VDK83791.1 - 0.071 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 VDK83791.1 - 0.078 13.5 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter PhoH PF02562.16 VDK83791.1 - 0.09 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Mg_chelatase PF01078.21 VDK83791.1 - 0.097 12.0 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_6 PF12774.7 VDK83791.1 - 0.12 11.3 0.0 0.42 9.5 0.0 1.8 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region DUF2075 PF09848.9 VDK83791.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 VDK83791.1 - 0.12 12.3 0.1 0.34 10.9 0.1 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_35 PF14516.6 VDK83791.1 - 0.14 11.0 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain Sigma54_activat PF00158.26 VDK83791.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PQ-loop PF04193.14 VDK83792.1 - 3.1e-34 116.6 9.6 3.5e-18 65.1 5.3 3.5 4 0 0 4 4 4 2 PQ loop repeat 2OG-FeII_Oxy_4 PF13661.6 VDK83794.1 - 7.5e-22 77.8 0.1 1.3e-21 77.1 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 VDK83794.1 - 4e-15 56.5 0.0 6.2e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ofd1_CTDD PF10637.9 VDK83794.1 - 6.7e-09 35.5 1.7 0.00056 19.3 0.6 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term BAF250_C PF12031.8 VDK83800.1 - 6.6e-84 281.2 2.8 1.3e-83 280.3 0.4 2.4 3 0 0 3 3 3 1 SWI/SNF-like complex subunit BAF250/Osa PhoLip_ATPase_C PF16212.5 VDK83801.1 - 8.9e-50 169.8 22.4 8.9e-50 169.8 22.4 3.0 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 VDK83801.1 - 6e-19 67.5 2.3 1.7e-18 66.0 2.3 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 VDK83801.1 - 1.4e-13 51.6 0.3 3.2e-06 27.6 0.1 2.7 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 VDK83801.1 - 8.1e-13 48.3 0.0 8.1e-13 48.3 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 VDK83801.1 - 5.4e-10 39.2 0.0 1e-08 35.1 0.0 2.8 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 VDK83801.1 - 0.0036 17.1 0.0 0.011 15.5 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Aph-1 PF06105.12 VDK83802.1 - 7.4e-68 228.4 19.8 9.4e-68 228.1 19.8 1.1 1 0 0 1 1 1 1 Aph-1 protein NMD3 PF04981.13 VDK83804.1 - 1.1e-65 221.5 9.0 1.8e-65 220.8 9.0 1.3 1 0 0 1 1 1 1 NMD3 family NinF PF05810.12 VDK83804.1 - 0.012 15.5 1.6 0.53 10.2 1.3 2.7 2 0 0 2 2 2 0 NinF protein DZR PF12773.7 VDK83804.1 - 0.013 15.5 5.5 0.18 11.9 1.5 3.0 2 1 0 2 2 2 0 Double zinc ribbon TMEM37 PF15108.6 VDK83804.1 - 0.032 14.1 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family Ank_2 PF12796.7 VDK83805.1 - 7.3e-45 151.5 16.7 5.4e-13 49.3 0.5 6.2 4 2 2 6 6 6 6 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDK83805.1 - 1.1e-36 120.7 12.2 2.5e-05 24.3 0.0 10.1 9 0 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.6 VDK83805.1 - 5.1e-32 109.8 13.2 3.4e-06 27.5 0.0 7.3 7 1 0 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 VDK83805.1 - 2.8e-28 97.1 18.8 9.7e-06 25.8 0.3 9.1 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 VDK83805.1 - 9.8e-26 89.5 16.9 6.9e-05 23.0 0.0 9.0 7 2 3 10 10 10 5 Ankyrin repeats (many copies) Roc PF08477.13 VDK83805.1 - 2.1e-21 76.4 0.1 2.1e-17 63.4 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase LRR_4 PF12799.7 VDK83805.1 - 6.2e-21 74.1 35.9 1.8e-05 25.0 0.5 8.3 5 2 5 10 10 10 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 VDK83805.1 - 1.7e-19 69.3 35.0 5.3e-05 22.9 2.6 7.1 7 1 0 7 7 7 4 Leucine rich repeat COR PF16095.5 VDK83805.1 - 2.6e-17 63.3 0.0 4.7e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal of Roc, COR, domain Ras PF00071.22 VDK83805.1 - 2.4e-07 30.5 0.0 6.3e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Ras family AAA_16 PF13191.6 VDK83805.1 - 0.0043 17.4 1.7 0.2 12.0 0.1 2.7 2 0 0 2 2 2 1 AAA ATPase domain LRR_1 PF00560.33 VDK83805.1 - 0.007 16.8 28.3 5.7 7.9 0.0 9.9 10 1 0 10 10 8 1 Leucine Rich Repeat NACHT PF05729.12 VDK83805.1 - 0.15 12.0 2.4 0.62 10.0 0.5 2.7 2 0 0 2 2 2 0 NACHT domain LRR_6 PF13516.6 VDK83805.1 - 0.35 11.0 25.8 1.3 9.2 0.1 8.5 10 0 0 10 10 9 0 Leucine Rich repeat Ldl_recept_a PF00057.18 VDK83807.1 - 5.3e-11 42.5 4.9 1.1e-10 41.5 4.9 1.5 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A PEPCK_GTP PF00821.18 VDK83808.1 - 2.9e-165 549.4 0.1 3.5e-165 549.1 0.1 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 VDK83808.1 - 2.6e-93 311.6 0.0 3.5e-93 311.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain Mito_carr PF00153.27 VDK83809.1 - 1.2e-47 159.8 1.5 7.6e-18 64.2 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein ECF_trnsprt PF12822.7 VDK83809.1 - 0.013 15.6 1.3 1.1 9.3 0.0 2.4 3 0 0 3 3 3 0 ECF transporter, substrate-specific component Fuseless PF15993.5 VDK83809.1 - 0.033 13.4 0.5 0.064 12.4 0.4 1.5 1 1 0 1 1 1 0 Fuseless LapA_dom PF06305.11 VDK83809.1 - 0.059 13.2 1.1 14 5.5 0.0 3.0 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain tRNA-synt_1 PF00133.22 VDK83810.1 - 6.7e-25 87.4 0.0 6.3e-24 84.2 0.0 2.5 2 1 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 VDK83810.1 - 4.5e-14 52.7 0.0 1.1e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 VDK83810.1 - 4.1e-07 29.1 0.3 5.2e-06 25.5 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 VDK83810.1 - 3.4e-05 23.3 0.0 7.6e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF4159 PF13709.6 VDK83810.1 - 0.014 14.9 0.1 0.12 11.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4159) BatA PF07584.11 VDK83811.1 - 0.042 14.2 0.5 0.05 14.0 0.5 1.2 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Arm PF00514.23 VDK83816.1 - 0.046 13.8 6.8 3.4 7.8 0.0 5.0 5 1 1 6 6 6 0 Armadillo/beta-catenin-like repeat INSC_LBD PF16748.5 VDK83817.1 - 0.15 11.5 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Inscuteable LGN-binding domain GSH_synth_ATP PF03917.17 VDK83819.1 - 6.4e-117 390.5 0.0 7.4e-117 390.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 VDK83819.1 - 1.4e-30 105.8 0.0 4.5e-30 104.1 0.0 1.9 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Noc2 PF03715.13 VDK83821.1 - 1.3e-79 267.6 7.5 6.9e-79 265.2 8.4 1.7 2 0 0 2 2 2 1 Noc2p family RIX1 PF08167.12 VDK83821.1 - 0.0012 18.6 2.1 0.0012 18.6 0.3 1.9 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Cys_Met_Meta_PP PF01053.20 VDK83826.1 - 2.3e-123 411.6 0.3 2.5e-123 411.4 0.3 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 VDK83826.1 - 6e-06 25.7 0.1 9.5e-06 25.0 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Met_gamma_lyase PF06838.11 VDK83826.1 - 0.00014 20.5 0.0 0.00018 20.1 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Cys_Met_Meta_PP PF01053.20 VDK83827.1 - 9.1e-14 50.8 0.0 9.7e-14 50.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PTPLA PF04387.14 VDK83833.1 - 3.2e-60 202.6 12.5 3.2e-60 202.6 12.5 1.4 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA CRAL_TRIO PF00650.20 VDK83834.1 - 1.1e-15 57.8 0.0 1.5e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Trigger_N PF05697.13 VDK83834.1 - 0.051 13.9 0.0 0.085 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) Glyco_hydro_30 PF02055.16 VDK83835.1 - 3e-150 500.0 1.0 3.7e-150 499.7 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 VDK83835.1 - 1.3e-09 38.1 0.0 2.6e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_59 PF02057.15 VDK83835.1 - 5.2e-05 22.6 0.0 8e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 CRAL_TRIO PF00650.20 VDK83836.1 - 6.3e-23 81.2 0.0 1e-22 80.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 VDK83836.1 - 0.018 15.2 0.4 0.085 13.0 0.3 2.0 2 1 0 2 2 2 0 Divergent CRAL/TRIO domain MAM PF00629.23 VDK83837.1 - 3.5e-11 43.3 0.0 0.0003 20.7 0.0 2.2 2 0 0 2 2 2 2 MAM domain, meprin/A5/mu RhoGEF PF00621.20 VDK83838.1 - 6.5e-36 124.3 1.3 1.4e-35 123.2 1.3 1.5 1 0 0 1 1 1 1 RhoGEF domain PTCB-BRCT PF12738.7 VDK83838.1 - 2.1e-13 50.0 0.4 1.3e-12 47.5 0.1 2.3 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 VDK83838.1 - 4.3e-05 23.7 0.3 0.00081 19.6 0.1 2.7 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain BRCT PF00533.26 VDK83838.1 - 0.00013 22.3 0.0 0.008 16.5 0.0 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 VDK83838.1 - 0.011 16.1 0.1 0.069 13.6 0.1 2.2 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Sec8_exocyst PF04048.14 VDK83838.1 - 0.12 12.3 0.0 0.56 10.1 0.0 2.2 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain PAX PF00292.18 VDK83839.1 - 9.6e-26 90.2 0.5 1.3e-25 89.7 0.5 1.2 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 VDK83839.1 - 5.1e-09 35.7 0.0 9.9e-09 34.8 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.6 VDK83839.1 - 1.9e-05 24.3 0.0 3.9e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 VDK83839.1 - 2.6e-05 24.1 0.0 6.7e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn helix HTH_28 PF13518.6 VDK83839.1 - 0.0027 17.8 0.0 0.0053 16.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_1 PF11427.8 VDK83839.1 - 0.009 15.8 0.2 0.019 14.8 0.2 1.5 1 0 0 1 1 1 1 Tc3 transposase Terminase_5 PF06056.12 VDK83839.1 - 0.018 14.9 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) PBP_sp32 PF07222.12 VDK83839.1 - 0.019 14.5 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 HTH_7 PF02796.15 VDK83839.1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DUF4817 PF16087.5 VDK83839.1 - 2.2 8.2 4.5 8.5 6.3 0.1 3.2 4 1 0 4 4 4 0 Helix-turn-helix domain (DUF4817) ELFV_dehydrog_N PF02812.18 VDK83843.1 - 3.6e-56 188.6 0.0 6.2e-56 187.8 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 VDK83843.1 - 7.6e-49 166.6 0.0 1.8e-45 155.6 0.0 2.2 1 1 1 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 VDK83843.1 - 0.052 12.9 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DEAD PF00270.29 VDK83845.1 - 1.8e-39 135.3 0.1 2.2e-39 135.0 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK83845.1 - 2.6e-08 34.0 0.0 3.8e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 VDK83845.1 - 2.6e-05 23.7 0.0 3.6e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Helicase_C PF00271.31 VDK83846.1 - 4.8e-26 91.3 0.1 7.5e-26 90.7 0.1 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CTX_RstB PF07459.11 VDK83846.1 - 0.081 13.2 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 CTX phage RstB protein KTI12 PF08433.10 VDK83847.1 - 6.6e-16 58.6 0.3 9.5e-16 58.0 0.3 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 VDK83847.1 - 3.9e-09 36.8 0.0 7.3e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 VDK83847.1 - 1.1e-06 29.2 0.0 3e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 VDK83847.1 - 2.6e-06 27.7 0.1 2.2e-05 24.8 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK83847.1 - 3.4e-06 27.5 0.1 5.7e-05 23.6 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 VDK83847.1 - 4.7e-05 23.8 0.0 0.00011 22.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 VDK83847.1 - 7.8e-05 23.0 0.0 0.00027 21.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 VDK83847.1 - 0.00089 19.7 0.1 0.0026 18.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.14 VDK83847.1 - 0.0012 18.9 0.0 0.0036 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 VDK83847.1 - 0.0013 18.0 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin NACHT PF05729.12 VDK83847.1 - 0.0079 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain PduV-EutP PF10662.9 VDK83847.1 - 0.0086 15.8 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 VDK83847.1 - 0.011 16.1 0.0 0.047 14.1 0.0 2.1 2 0 0 2 2 2 0 RNA helicase ATP_bind_1 PF03029.17 VDK83847.1 - 0.018 14.8 1.3 0.055 13.2 0.1 2.2 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 VDK83847.1 - 0.028 14.2 0.1 0.087 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 VDK83847.1 - 0.033 13.9 0.1 1.3 8.6 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase Viral_helicase1 PF01443.18 VDK83847.1 - 0.036 13.8 0.2 0.093 12.5 0.1 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 VDK83847.1 - 0.078 12.9 0.2 0.34 10.8 0.1 2.0 2 0 0 2 2 2 0 NTPase AAA_14 PF13173.6 VDK83847.1 - 0.099 12.7 0.0 0.29 11.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 VDK83847.1 - 0.1 13.0 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 VDK83847.1 - 0.12 12.3 0.1 3.1 7.7 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_30 PF13604.6 VDK83847.1 - 0.18 11.5 0.1 0.29 10.8 0.1 1.3 1 0 0 1 1 1 0 AAA domain FLYWCH PF04500.16 VDK83848.1 - 0.011 15.8 2.5 0.011 15.8 2.5 2.0 2 0 0 2 2 2 0 FLYWCH zinc finger domain Metalloenzyme PF01676.18 VDK83850.1 - 8.4e-77 257.9 0.1 9.8e-77 257.7 0.1 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 VDK83850.1 - 1.2e-73 247.2 0.2 1.7e-73 246.7 0.2 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 VDK83850.1 - 9.5e-06 25.4 0.0 1.5e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 VDK83850.1 - 0.0026 17.2 0.0 0.0058 16.1 0.0 1.7 1 1 0 1 1 1 1 Sulfatase Alk_phosphatase PF00245.20 VDK83850.1 - 0.0047 15.9 0.0 0.0095 14.9 0.0 1.5 1 0 0 1 1 1 1 Alkaline phosphatase Voltage_CLC PF00654.20 VDK83855.1 - 2.9e-61 207.7 39.5 5.4e-40 137.7 11.4 3.0 1 1 2 3 3 3 3 Voltage gated chloride channel CBS PF00571.28 VDK83855.1 - 1.1e-07 32.2 0.3 0.0051 17.2 0.0 2.8 2 0 0 2 2 2 2 CBS domain Thioredoxin_7 PF13899.6 VDK83856.1 - 2.6e-14 53.2 0.1 4.8e-14 52.3 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredox_DsbH PF03190.15 VDK83856.1 - 9.5e-09 35.4 0.1 1.5e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_2 PF13098.6 VDK83856.1 - 0.0006 20.2 0.5 0.002 18.6 0.7 2.0 2 1 0 2 2 2 1 Thioredoxin-like domain AhpC-TSA PF00578.21 VDK83856.1 - 0.0011 18.9 0.2 0.0015 18.4 0.2 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 VDK83856.1 - 0.0027 18.0 0.9 0.019 15.2 0.7 2.5 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin PF00085.20 VDK83856.1 - 0.066 13.2 1.0 0.082 12.9 0.2 1.6 2 0 0 2 2 2 0 Thioredoxin HLH PF00010.26 VDK83857.1 - 3.6e-17 62.1 5.2 3.6e-17 62.1 5.2 1.9 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF1616 PF07760.11 VDK83857.1 - 0.005 16.3 1.8 0.0096 15.3 1.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF1616) Trans_reg_C PF00486.28 VDK83857.1 - 0.038 14.1 1.2 6.6 6.9 0.6 2.4 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal Sec63 PF02889.16 VDK83858.1 - 1.2e-70 237.6 1.0 1.7e-70 237.2 1.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 VDK83858.1 - 1.9e-05 24.5 0.1 8.8e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF603 PF04645.12 VDK83858.1 - 0.00064 19.5 0.1 0.0015 18.3 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF603 CAP PF00188.26 VDK83861.1 - 1.7e-25 90.3 1.7 2.3e-25 89.9 1.7 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peptidase_C2 PF00648.21 VDK83862.1 - 1.1e-45 155.9 0.0 2.1e-45 155.0 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease MIT PF04212.18 VDK83862.1 - 7.9e-18 64.3 11.2 6.4e-10 39.0 1.8 2.5 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Calpain_III PF01067.22 VDK83862.1 - 0.0029 17.9 1.6 0.11 12.7 0.0 3.1 3 0 0 3 3 3 1 Calpain large subunit, domain III BRO1 PF03097.18 VDK83862.1 - 0.027 13.3 0.9 0.04 12.7 0.9 1.2 1 0 0 1 1 1 0 BRO1-like domain DUF236 PF03057.14 VDK83863.1 - 0.0083 16.1 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 DUF236 repeat Cas_VVA1548 PF09652.10 VDK83863.1 - 0.009 16.2 0.1 1.3 9.3 0.0 2.3 2 0 0 2 2 2 2 Putative CRISPR-associated protein (Cas_VVA1548) Methyltransf_11 PF08241.12 VDK83864.1 - 1.1e-13 51.7 0.0 2.2e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK83864.1 - 4.8e-11 43.2 0.0 1e-10 42.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain 2OG-FeII_Oxy_2 PF13532.6 VDK83864.1 - 1.2e-07 32.1 0.1 8.4e-07 29.4 0.0 2.2 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Methyltransf_31 PF13847.6 VDK83864.1 - 2e-05 24.4 0.6 0.00011 22.1 0.4 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 VDK83864.1 - 0.0002 21.3 0.3 0.00038 20.4 0.3 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.12 VDK83864.1 - 0.00027 21.6 0.1 0.0016 19.1 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 VDK83864.1 - 0.00092 18.6 0.0 0.0036 16.7 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 VDK83864.1 - 0.0039 17.0 0.0 0.0097 15.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain RRM_1 PF00076.22 VDK83864.1 - 0.015 15.1 0.1 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Methyltransf_9 PF08003.11 VDK83864.1 - 0.079 11.9 0.0 0.87 8.5 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1698) SH2 PF00017.24 VDK83877.1 - 4.2e-11 42.8 0.2 7.1e-11 42.1 0.2 1.4 1 0 0 1 1 1 1 SH2 domain SOCS_box PF07525.16 VDK83877.1 - 2.9e-07 30.7 0.0 7.3e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 SOCS box RFC1 PF08519.12 VDK83881.1 - 1.1e-45 155.6 0.0 8.6e-45 152.7 0.0 2.5 3 0 0 3 3 3 1 Replication factor RFC1 C terminal domain AAA PF00004.29 VDK83881.1 - 4.1e-14 53.1 0.0 1.2e-13 51.6 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 VDK83881.1 - 0.00024 20.9 1.5 0.014 15.2 0.1 2.6 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_18 PF13238.6 VDK83881.1 - 0.0003 21.3 0.1 0.0015 19.1 0.1 2.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 VDK83881.1 - 0.00035 20.6 0.0 0.00098 19.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 VDK83881.1 - 0.00054 19.7 0.0 0.0018 18.0 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK83881.1 - 0.0025 18.1 0.3 0.02 15.2 0.3 2.4 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 VDK83881.1 - 0.0087 16.0 2.4 0.063 13.2 0.7 3.0 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 VDK83881.1 - 0.015 15.7 0.0 0.044 14.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 VDK83881.1 - 0.038 13.9 2.0 0.084 12.8 0.0 2.6 2 1 1 3 3 3 0 NTPase AAA_25 PF13481.6 VDK83881.1 - 0.039 13.5 0.0 0.094 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 VDK83881.1 - 0.051 13.7 0.0 0.17 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 VDK83881.1 - 0.071 13.2 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 VDK83881.1 - 0.12 12.8 0.1 0.51 10.8 0.1 2.1 1 1 0 1 1 1 0 RNA helicase ResIII PF04851.15 VDK83881.1 - 0.35 10.9 5.9 2.3 8.2 0.0 3.1 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit HSP20 PF00011.21 VDK83883.1 - 3.5e-11 43.1 0.2 6.8e-11 42.2 0.2 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK83883.1 - 0.0033 16.9 0.0 0.0058 16.2 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA zf-C3HC4_3 PF13920.6 VDK83884.1 - 1.2e-09 37.9 15.0 1.2e-09 37.9 15.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF3584 PF12128.8 VDK83884.1 - 0.0034 15.0 20.8 0.0047 14.5 20.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Prok-RING_4 PF14447.6 VDK83884.1 - 0.005 16.7 13.9 0.005 16.7 13.9 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 VDK83884.1 - 0.022 15.1 18.4 0.041 14.2 14.1 2.6 2 0 0 2 2 2 0 Ring finger domain CC2-LZ PF16516.5 VDK83884.1 - 0.083 13.3 20.9 0.56 10.6 10.1 3.0 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator zf-RING_5 PF14634.6 VDK83884.1 - 0.097 12.7 17.5 0.063 13.2 13.0 2.5 2 0 0 2 2 2 0 zinc-RING finger domain UBA_2 PF08587.11 VDK83884.1 - 0.12 12.5 0.7 0.48 10.6 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) GAS PF13851.6 VDK83884.1 - 0.35 10.2 28.0 2.3 7.5 8.4 2.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding ERM PF00769.19 VDK83884.1 - 0.88 9.3 23.3 4.4 7.0 12.1 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family GAGA_bind PF06217.12 VDK83884.1 - 0.94 9.7 6.0 1.3 9.2 6.0 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family USP8_interact PF08941.10 VDK83884.1 - 0.99 9.2 8.1 4.3 7.1 1.4 2.5 1 1 2 3 3 3 0 USP8 interacting ADIP PF11559.8 VDK83884.1 - 1.3 9.1 23.9 0.26 11.3 7.2 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 VDK83884.1 - 1.5 9.5 14.7 2.4 8.9 2.5 3.1 1 1 1 2 2 2 0 Initiation control protein YabA DUF745 PF05335.13 VDK83884.1 - 1.6 8.4 12.8 0.16 11.7 4.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF745) Lebercilin PF15619.6 VDK83884.1 - 3.9 7.1 30.1 3.5 7.2 4.3 2.7 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF641 PF04859.12 VDK83884.1 - 5 7.5 21.1 6.7 7.1 5.0 3.8 2 1 2 4 4 4 0 Plant protein of unknown function (DUF641) Cauli_VI PF01693.16 VDK83900.1 - 9.5e-19 67.4 2.4 1.1e-18 67.2 2.4 1.1 1 0 0 1 1 1 1 Caulimovirus viroplasmin Snf7 PF03357.21 VDK83904.1 - 1e-30 106.6 19.2 1.4e-30 106.2 19.2 1.1 1 0 0 1 1 1 1 Snf7 YqaH PF17448.2 VDK83904.1 - 0.014 15.7 1.9 1.2 9.4 0.2 2.6 1 1 1 2 2 2 0 Uncharacterized YqaH-like LPD14 PF18827.1 VDK83904.1 - 0.033 14.5 0.7 0.063 13.5 0.7 1.6 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 14 CENP-Q PF13094.6 VDK83904.1 - 0.083 13.1 6.4 0.16 12.2 6.4 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Methyltrans_Mon PF14314.6 VDK83904.1 - 0.11 10.4 2.5 0.15 10.1 2.5 1.1 1 0 0 1 1 1 0 Virus-capping methyltransferase zf-CCCH_6 PF18585.1 VDK83904.1 - 0.2 11.6 1.7 1.4 8.9 0.2 2.8 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DUF3490 PF11995.8 VDK83904.1 - 1.9 8.3 9.5 1.2 9.0 7.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3490) Mss4 PF04421.13 VDK83905.1 - 2.6e-18 65.9 0.3 4.9e-18 65.1 0.0 1.5 2 0 0 2 2 2 1 Mss4 protein DUF2552 PF10827.8 VDK83905.1 - 0.00029 21.0 0.0 0.00079 19.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2552) Ribosomal_L37e PF01907.19 VDK83905.1 - 0.0097 16.0 3.2 0.074 13.2 1.5 2.3 2 0 0 2 2 2 1 Ribosomal protein L37e DUF2452 PF10504.9 VDK83905.1 - 0.035 13.6 0.2 0.049 13.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) Peptidase_M10 PF00413.24 VDK83906.1 - 2e-35 122.0 0.0 2.4e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Matrixin DUF4953 PF16313.5 VDK83906.1 - 0.00052 19.3 0.7 0.00082 18.7 0.7 1.2 1 0 0 1 1 1 1 Met-zincin Peptidase_M57 PF12388.8 VDK83906.1 - 0.0012 18.5 0.1 0.0018 18.0 0.1 1.4 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Reprolysin_3 PF13582.6 VDK83906.1 - 0.0016 18.9 0.1 0.0023 18.4 0.1 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 VDK83906.1 - 0.012 15.6 0.0 0.019 15.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M54 Metallopep PF12044.8 VDK83906.1 - 0.014 14.0 0.1 0.021 13.5 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_5 PF13688.6 VDK83906.1 - 0.024 14.8 0.1 0.036 14.2 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M66 PF10462.9 VDK83906.1 - 0.051 12.5 0.7 0.091 11.7 0.7 1.5 2 0 0 2 2 2 0 Peptidase M66 Reprolysin_4 PF13583.6 VDK83906.1 - 0.093 12.4 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 VDK83906.1 - 0.13 11.9 0.1 0.25 11.0 0.1 1.5 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Shisa PF13908.6 VDK83907.1 - 0.019 15.2 2.1 0.02 15.2 0.3 1.8 1 1 2 3 3 3 0 Wnt and FGF inhibitory regulator TadF PF16964.5 VDK83907.1 - 0.02 14.7 4.7 0.035 13.9 4.7 1.6 1 1 0 1 1 1 0 Putative tight adherence pilin protein F ChlamPMP_M PF07548.11 VDK83907.1 - 0.074 13.0 3.0 0.095 12.7 3.0 1.2 1 0 0 1 1 1 0 Chlamydia polymorphic membrane protein middle domain DUF4834 PF16118.5 VDK83907.1 - 0.28 12.2 8.1 2.2 9.3 8.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Anillin PF08174.11 VDK83908.1 - 2.8e-14 53.7 0.2 9.9e-14 52.0 0.2 2.1 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 VDK83908.1 - 2.6e-11 44.0 0.1 1.5e-09 38.3 0.0 3.3 3 0 0 3 3 3 1 PH domain WRW PF10206.9 VDK83909.1 - 5.4e-23 81.3 0.2 7.5e-23 80.8 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f Thymidylate_kin PF02223.17 VDK83910.1 - 1.1e-41 142.6 0.0 1.3e-41 142.3 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase PPK2 PF03976.14 VDK83910.1 - 0.076 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) AAA_18 PF13238.6 VDK83910.1 - 0.14 12.7 0.0 0.28 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-H2C2_2 PF13465.6 VDK83911.1 - 4.3e-17 61.7 24.9 5.8e-09 36.0 0.8 5.0 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 VDK83911.1 - 8.1e-17 60.7 22.6 3.9e-06 27.0 1.4 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK83911.1 - 9.4e-09 35.4 26.0 0.00048 20.7 0.9 4.0 4 0 0 4 4 3 3 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK83911.1 - 1.2e-07 31.3 7.3 1.9e-06 27.5 2.2 4.8 5 1 0 5 5 4 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 VDK83911.1 - 2.3e-05 24.6 11.7 0.021 15.1 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK83911.1 - 7.7e-05 22.6 21.1 0.011 15.7 0.3 3.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-BED PF02892.15 VDK83911.1 - 0.00066 19.6 11.3 0.035 14.1 0.2 3.0 1 1 2 3 3 3 2 BED zinc finger zf-C2H2_11 PF16622.5 VDK83911.1 - 0.001 18.8 4.3 0.018 14.8 0.3 3.7 4 0 0 4 4 4 2 zinc-finger C2H2-type GAGA PF09237.11 VDK83911.1 - 0.0036 17.1 9.3 0.95 9.3 0.2 3.6 1 1 2 3 3 3 2 GAGA factor PyrI_C PF02748.15 VDK83911.1 - 0.065 13.1 10.8 0.24 11.4 0.4 3.7 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-Di19 PF05605.12 VDK83911.1 - 0.099 12.9 8.5 0.78 10.1 2.9 2.5 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-MYST PF17772.1 VDK83911.1 - 0.19 11.4 4.6 2.5 7.8 0.0 3.2 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C2HE PF16278.5 VDK83911.1 - 0.26 11.8 13.2 1.3 9.5 3.0 3.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_2 PF12756.7 VDK83911.1 - 0.4 11.1 8.7 2.2 8.7 0.1 3.2 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) DUF3070 PF11270.8 VDK83911.1 - 0.54 10.5 6.6 0.13 12.5 2.8 2.0 2 0 0 2 2 1 0 Protein of unknown function (DUF3070) zf-met PF12874.7 VDK83911.1 - 2.3 8.7 13.7 2 8.9 0.2 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 VDK83911.1 - 6.6 7.6 13.4 0.7 10.7 0.8 3.3 3 1 0 4 4 4 0 zinc-ribbon family zf-AN1 PF01428.16 VDK83911.1 - 6.8 7.0 14.5 8.6 6.6 0.2 4.1 4 0 0 4 4 4 0 AN1-like Zinc finger C1_1 PF00130.22 VDK83911.1 - 8 6.4 11.7 0.45 10.4 0.2 3.0 2 1 2 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-met2 PF12907.7 VDK83911.1 - 8.4 6.6 7.7 1.8 8.8 1.3 2.8 2 0 0 2 2 2 0 Zinc-binding zf-C2H2_3rep PF18868.1 VDK83911.1 - 9.4 6.9 10.5 11 6.7 0.2 3.2 2 1 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats Ribosomal_L26 PF16906.5 VDK83917.1 - 3.9e-26 91.3 0.5 5.8e-26 90.8 0.5 1.3 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 VDK83917.1 - 7e-07 29.0 2.4 1.8e-06 27.7 1.5 2.1 3 0 0 3 3 3 1 KOW motif DUF1445 PF07286.12 VDK83917.1 - 0.09 12.7 0.2 0.12 12.3 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1445) UPF0242 PF06785.11 VDK83918.1 - 0.14 12.3 15.2 0.33 11.0 15.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CC PF04942.14 VDK83919.1 - 1.7e-07 31.3 20.7 0.00066 19.8 0.6 4.0 4 0 0 4 4 4 3 CC domain Motile_Sperm PF00635.26 VDK83920.1 - 9.7e-20 70.5 0.1 9.7e-20 70.5 0.1 2.7 2 2 1 3 3 3 1 MSP (Major sperm protein) domain PapD_N PF00345.20 VDK83920.1 - 0.00053 19.9 0.0 0.002 18.0 0.0 2.0 1 0 0 1 1 1 1 Pili and flagellar-assembly chaperone, PapD N-terminal domain ASH PF15780.5 VDK83920.1 - 0.0028 17.8 0.0 0.0044 17.2 0.0 1.2 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Smg8_Smg9 PF10220.9 VDK83920.1 - 0.66 8.2 15.6 0.68 8.2 15.6 1.1 1 0 0 1 1 1 0 Smg8_Smg9 CDC27 PF09507.10 VDK83920.1 - 2.2 7.6 47.0 2.6 7.3 47.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MCM PF00493.23 VDK83922.1 - 1.4e-100 335.0 0.0 4.2e-100 333.5 0.0 1.7 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 VDK83922.1 - 1.1e-31 109.3 0.2 2.1e-31 108.4 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 VDK83922.1 - 3.9e-26 91.3 0.5 1e-25 90.0 0.5 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 VDK83922.1 - 2.5e-13 50.6 29.7 2.5e-13 50.6 29.7 2.7 2 1 1 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 VDK83922.1 - 3.4e-12 46.8 2.6 6.2e-12 46.0 0.1 2.8 4 0 0 4 4 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 VDK83922.1 - 1.5e-08 34.3 0.1 8.4e-07 28.6 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 VDK83922.1 - 3.5e-08 33.5 0.0 6.7e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 VDK83922.1 - 3.9e-05 23.5 0.0 0.00016 21.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 VDK83922.1 - 0.005 17.3 0.0 0.04 14.4 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 VDK83922.1 - 0.016 15.0 0.0 0.73 9.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_lid_2 PF17863.1 VDK83922.1 - 0.053 13.4 0.5 0.25 11.2 0.1 2.4 2 0 0 2 2 2 0 AAA lid domain AAA_2 PF07724.14 VDK83922.1 - 0.15 12.1 2.8 0.46 10.6 0.0 2.8 2 1 1 3 3 3 0 AAA domain (Cdc48 subfamily) MADF_DNA_bdg PF10545.9 VDK83923.1 - 3.1e-16 59.4 0.6 3.1e-16 59.4 0.6 2.1 2 1 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.6 VDK83923.1 - 0.00071 19.6 0.4 0.0021 18.1 0.4 1.7 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 VDK83923.1 - 0.0014 19.0 0.2 0.0014 19.0 0.2 2.3 2 1 0 3 3 3 1 Myb/SANT-like DNA-binding domain BESS PF02944.20 VDK83923.1 - 0.0029 17.4 0.7 0.0067 16.2 0.7 1.5 1 0 0 1 1 1 1 BESS motif GRP PF07172.11 VDK83924.1 - 3.9 8.2 28.0 4.5 8.0 28.0 1.1 1 0 0 1 1 1 0 Glycine rich protein family ATG_C PF09333.11 VDK83939.1 - 3.6e-18 65.7 0.0 1.2e-17 64.0 0.0 1.9 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 VDK83939.1 - 6e-08 32.7 0.0 4.4e-07 29.8 0.0 2.4 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal ATG2_CAD PF13329.6 VDK83939.1 - 0.002 17.9 0.9 0.038 13.7 0.0 2.6 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif SAM_2 PF07647.17 VDK83940.1 - 5.1e-24 84.2 1.1 3.1e-09 36.8 0.0 4.0 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 VDK83940.1 - 3.9e-23 81.7 1.5 6.3e-10 39.3 0.1 4.3 4 0 0 4 4 4 3 SAM domain (Sterile alpha motif) GAS PF13851.6 VDK83940.1 - 0.16 11.3 103.9 0.047 13.1 15.3 7.1 2 1 5 7 7 7 0 Growth-arrest specific micro-tubule binding TraF_2 PF13729.6 VDK83940.1 - 0.22 10.8 2.6 30 3.9 1.7 3.1 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein Mtc PF03820.17 VDK83941.1 - 1.1e-108 363.1 1.3 1.2e-108 362.9 1.3 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier SH3_1 PF00018.28 VDK83942.1 - 3.4e-35 119.4 1.2 2.3e-16 59.1 0.1 3.2 3 0 0 3 3 3 2 SH3 domain SH3_9 PF14604.6 VDK83942.1 - 4.5e-31 106.5 0.1 4.6e-16 58.4 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 VDK83942.1 - 6.9e-28 96.1 0.0 3.5e-15 55.4 0.0 2.6 2 1 0 2 2 2 2 Variant SH3 domain SH2 PF00017.24 VDK83942.1 - 2.8e-26 91.4 0.0 6.2e-26 90.3 0.0 1.6 1 0 0 1 1 1 1 SH2 domain SH3_3 PF08239.11 VDK83942.1 - 0.00033 20.9 1.7 0.0021 18.3 0.0 2.5 3 0 0 3 3 3 1 Bacterial SH3 domain DUF5093 PF17011.5 VDK83942.1 - 0.0093 16.3 0.0 0.021 15.1 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5093) SH3_10 PF17902.1 VDK83942.1 - 0.12 12.5 0.0 28 4.9 0.0 2.6 3 0 0 3 3 3 0 SH3 domain TTR-52 PF01060.23 VDK83943.1 - 1.2e-28 99.6 0.0 1.7e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Transthyretin-like family bMG3 PF11974.8 VDK83943.1 - 0.2 11.7 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain Rap_GAP PF02145.15 VDK83949.1 - 4.8e-67 225.1 0.1 8.3e-67 224.3 0.1 1.4 1 0 0 1 1 1 1 Rap/ran-GAP PDZ_6 PF17820.1 VDK83949.1 - 1.7e-06 27.8 0.0 2e-05 24.3 0.0 2.4 2 0 0 2 2 2 1 PDZ domain FAM86 PF14904.6 VDK83949.1 - 0.11 12.6 0.1 6.8 6.9 0.0 2.9 2 0 0 2 2 2 0 Family of unknown function Swi5 PF07061.11 VDK83949.1 - 0.76 9.9 3.6 2.2 8.4 3.6 1.7 1 0 0 1 1 1 0 Swi5 Cnd3 PF12719.7 VDK83950.1 - 1.3e-12 47.5 0.1 9e-12 44.8 0.1 2.3 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 VDK83950.1 - 3.2e-06 27.4 0.0 3.2e-05 24.2 0.0 2.7 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 VDK83950.1 - 0.003 17.7 0.0 18 6.0 0.0 4.5 4 0 0 4 4 4 2 HEAT repeat Patched PF02460.18 VDK83959.1 - 3.2e-84 283.5 5.8 3.8e-84 283.3 5.8 1.0 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK83959.1 - 3.8e-38 130.7 2.5 1e-37 129.3 2.5 1.7 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK83959.1 - 8.8e-07 28.2 1.4 1.3e-06 27.6 1.4 1.2 1 0 0 1 1 1 1 MMPL family Pox_H7 PF04787.12 VDK83959.1 - 0.098 13.2 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Late protein H7 Peptidase_S10 PF00450.22 VDK83960.1 - 4.3e-123 411.8 0.3 6.3e-123 411.3 0.3 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase ANAPC4_WD40 PF12894.7 VDK83960.1 - 5.3e-07 29.8 2.2 0.027 14.8 0.1 4.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK83960.1 - 1.1e-06 29.3 13.4 0.054 14.4 0.0 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat Hira PF07569.11 VDK83960.1 - 0.042 13.6 0.2 0.11 12.2 0.2 1.7 1 0 0 1 1 1 0 TUP1-like enhancer of split Peptidase_S9 PF00326.21 VDK83960.1 - 0.084 12.3 0.0 0.24 10.8 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family Mucin PF01456.17 VDK83961.1 - 0.13 12.3 16.8 0.17 11.9 16.8 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein SDF PF00375.18 VDK83961.1 - 0.22 10.5 10.2 0.29 10.1 10.2 1.1 1 0 0 1 1 1 0 Sodium:dicarboxylate symporter family ATP-synt_C PF00137.21 VDK83963.1 - 1.2e-21 76.8 37.6 8.6e-12 45.2 8.8 2.7 3 0 0 3 3 3 2 ATP synthase subunit C DUF1539 PF07560.11 VDK83964.1 - 0.0097 16.0 0.1 0.011 15.8 0.1 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1539) Sec63 PF02889.16 VDK83965.1 - 5.5e-86 287.9 0.2 9.5e-86 287.1 0.2 1.4 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_PWI PF18149.1 VDK83965.1 - 2.5e-37 127.5 2.1 2.5e-37 127.5 2.1 2.0 2 0 0 2 2 2 1 N-terminal helicase PWI domain DEAD PF00270.29 VDK83965.1 - 6e-25 88.0 0.1 2.1e-24 86.2 0.1 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK83965.1 - 4.3e-15 56.1 0.0 1.3e-14 54.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 VDK83965.1 - 3.8e-07 30.4 0.0 6.2e-06 26.5 0.0 2.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 VDK83965.1 - 0.00072 19.8 0.1 0.0044 17.3 0.0 2.4 2 1 0 2 2 2 1 AAA domain SNF2_N PF00176.23 VDK83965.1 - 0.027 13.2 0.1 0.062 12.0 0.1 1.6 1 0 0 1 1 1 0 SNF2 family N-terminal domain RuvB_N PF05496.12 VDK83965.1 - 0.04 13.7 0.3 5.8 6.6 0.0 3.1 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 VDK83965.1 - 0.16 11.7 1.9 0.51 10.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Vinculin PF01044.19 VDK83972.1 - 2.6e-201 671.4 25.7 1.2e-163 546.7 20.7 3.4 2 1 1 3 3 3 3 Vinculin family ODR4-like PF14778.6 VDK83972.1 - 0.019 14.0 1.9 0.028 13.4 0.1 2.2 2 0 0 2 2 2 0 Olfactory receptor 4-like U62_UL91 PF17442.2 VDK83972.1 - 0.031 14.3 0.1 0.18 11.8 0.0 2.3 2 0 0 2 2 2 0 Functional domain of U62 and UL91 proteins Cas_DxTHG PF09455.10 VDK83972.1 - 0.12 11.9 2.0 0.38 10.3 1.3 2.2 2 0 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family DUF4363 PF14276.6 VDK83972.1 - 0.23 11.6 2.0 1.1 9.5 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) I_LWEQ PF01608.17 VDK83972.1 - 9.5 6.5 17.6 0.094 13.0 3.6 3.6 3 1 1 4 4 4 0 I/LWEQ domain Syja_N PF02383.18 VDK83974.1 - 4.5e-80 269.3 0.1 6.1e-80 268.9 0.1 1.2 1 0 0 1 1 1 1 SacI homology domain EAF PF09816.9 VDK83975.1 - 2e-18 66.6 0.0 3.6e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor FH2 PF02181.23 VDK83977.1 - 4.5e-66 223.5 1.5 6.4e-66 223.0 0.0 1.8 2 0 0 2 2 2 1 Formin Homology 2 Domain Metallophos PF00149.28 VDK83990.1 - 3.6e-35 122.3 0.1 4.5e-35 122.0 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SGL PF08450.12 VDK83991.1 - 3.2e-05 23.7 0.0 0.00051 19.7 0.0 2.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 VDK83991.1 - 4.8e-05 23.4 0.0 0.00079 19.5 0.0 2.7 2 1 1 3 3 3 1 Strictosidine synthase zf-C3HC4_3 PF13920.6 VDK83992.1 - 4.9e-11 42.3 8.3 7.3e-11 41.8 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK83992.1 - 2.9e-09 36.6 7.6 4.7e-09 36.0 7.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 VDK83992.1 - 1.1e-08 35.2 11.2 1.9e-08 34.5 11.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK83992.1 - 3.9e-08 33.2 6.8 1.1e-07 31.7 6.9 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 VDK83992.1 - 1.1e-07 31.5 11.1 1.8e-07 30.9 11.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK83992.1 - 1.4e-07 31.4 10.4 2.7e-07 30.4 10.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 VDK83992.1 - 5.6e-07 29.3 10.3 1e-06 28.4 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 VDK83992.1 - 3.8e-06 27.0 11.3 7.5e-06 26.0 11.3 1.5 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 VDK83992.1 - 7.6e-06 26.1 7.9 1.4e-05 25.3 7.9 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 VDK83992.1 - 0.0063 16.5 5.8 0.019 15.0 5.8 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 VDK83992.1 - 0.083 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 U-box domain zf-RING_11 PF17123.5 VDK83992.1 - 0.83 9.5 9.3 0.56 10.0 6.9 2.0 2 1 0 2 2 2 0 RING-like zinc finger ODR4-like PF14778.6 VDK83993.1 - 4.9e-61 206.7 0.0 5.9e-61 206.4 0.0 1.1 1 0 0 1 1 1 1 Olfactory receptor 4-like DUF1091 PF06477.13 VDK83994.1 - 0.29 11.6 3.8 3.6 8.1 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1091) Gpi16 PF04113.14 VDK83996.1 - 1.4e-90 304.4 1.8 6.9e-60 203.1 0.0 3.0 1 1 2 3 3 3 3 Gpi16 subunit, GPI transamidase component EGF PF00008.27 VDK84006.1 - 0.002 18.4 52.9 0.005 17.1 7.4 5.6 5 1 0 5 5 5 3 EGF-like domain hEGF PF12661.7 VDK84006.1 - 0.0047 17.5 46.3 0.0048 17.5 6.2 5.2 5 0 0 5 5 5 3 Human growth factor-like EGF EGF_2 PF07974.13 VDK84006.1 - 0.012 16.0 52.5 0.016 15.5 11.8 4.6 5 0 0 5 5 5 0 EGF-like domain FOLN PF09289.10 VDK84006.1 - 0.59 10.4 8.1 0.46 10.7 4.6 2.8 2 0 0 2 2 2 0 Follistatin/Osteonectin-like EGF domain PDEase_I PF00233.19 VDK84009.1 - 1.7e-61 208.0 6.8 1.7e-61 208.0 3.9 2.3 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I_N PF08499.12 VDK84009.1 - 8.4e-21 73.6 0.1 2.4e-20 72.1 0.1 1.8 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase N-terminal DSPc PF00782.20 VDK84011.1 - 7.3e-32 110.0 0.0 9.1e-32 109.7 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK84011.1 - 0.0012 18.5 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DAG1 PF05454.11 VDK84011.1 - 0.22 10.9 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DSPc PF00782.20 VDK84012.1 - 1.2e-33 115.7 0.0 1.7e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK84012.1 - 0.0015 18.1 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK84013.1 - 1.3e-26 93.0 0.0 1.7e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DEAD PF00270.29 VDK84014.1 - 1.1e-44 152.2 0.2 2.7e-44 151.0 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK84014.1 - 2.4e-25 89.0 0.0 5.4e-24 84.7 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 VDK84014.1 - 1.3e-18 66.9 0.2 2.8e-18 65.9 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 VDK84014.1 - 5e-07 29.9 0.4 1.2e-06 28.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 VDK84014.1 - 0.00093 18.6 0.0 0.0027 17.0 0.0 1.7 2 0 0 2 2 2 1 SecA DEAD-like domain DUF2075 PF09848.9 VDK84014.1 - 0.04 13.2 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 VDK84014.1 - 0.41 10.9 1.5 1.4 9.2 1.5 2.0 1 1 0 1 1 1 0 AAA domain Archease PF01951.16 VDK84016.1 - 2.7e-40 137.8 0.3 3.1e-40 137.6 0.3 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) Maf1 PF09174.10 VDK84017.1 - 1.3e-46 158.9 0.6 1.6e-46 158.6 0.6 1.1 1 0 0 1 1 1 1 Maf1 regulator TSC22 PF01166.18 VDK84018.1 - 0.14 12.5 0.1 0.14 12.5 0.1 7.4 7 1 1 9 9 9 0 TSC-22/dip/bun family DUF851 PF05867.11 VDK84022.1 - 6.3e-16 58.6 3.6 8.7e-16 58.1 3.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF851) BACK PF07707.15 VDK84023.1 - 4e-07 30.1 0.1 1.4e-06 28.3 0.1 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch CobD_Cbib PF03186.13 VDK84023.1 - 0.079 12.2 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 CobD/Cbib protein Pkinase PF00069.25 VDK84024.1 - 1.9e-59 201.2 0.0 4.5e-59 200.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84024.1 - 1.9e-34 119.1 0.0 4.3e-34 118.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK84024.1 - 9.4e-06 25.1 0.0 1.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Coiled-coil_56 PF09813.9 VDK84024.1 - 0.0025 17.8 0.1 0.0067 16.5 0.1 1.7 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 Metallophos PF00149.28 VDK84026.1 - 1.4e-37 130.2 0.2 1.8e-37 129.9 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK84026.1 - 0.0024 18.3 0.2 0.0041 17.5 0.2 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Thioredoxin PF00085.20 VDK84030.1 - 1.6e-10 40.9 0.1 4e-08 33.2 0.1 2.6 2 0 0 2 2 2 2 Thioredoxin FAD_SOX PF18371.1 VDK84030.1 - 1.1e-05 25.7 0.0 0.013 15.9 0.0 2.6 1 1 1 2 2 2 2 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase QSOX_Trx1 PF18108.1 VDK84030.1 - 0.0001 22.4 0.1 0.00031 20.9 0.0 1.8 1 1 1 2 2 2 1 QSOX Trx-like domain Thioredoxin_8 PF13905.6 VDK84030.1 - 0.00026 21.3 0.4 0.0027 18.0 0.1 2.6 1 1 1 2 2 2 1 Thioredoxin-like SAS4 PF15460.6 VDK84032.1 - 0.041 14.0 0.1 0.049 13.7 0.1 1.1 1 0 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 Swi3 PF07962.12 VDK84034.1 - 9.9e-19 67.1 0.1 2e-18 66.1 0.1 1.5 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 DUF1725 PF08333.11 VDK84035.1 - 0.12 12.0 0.8 0.17 11.5 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1725) HMG-CoA_red PF00368.18 VDK84036.1 - 1.5e-129 432.2 2.3 1.9e-129 431.9 2.3 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Peptidase_M28 PF04389.17 VDK84038.1 - 4.9e-20 72.1 0.0 1.2e-19 70.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M28 TFR_dimer PF04253.15 VDK84038.1 - 1.1e-13 51.3 0.4 3e-13 49.9 0.1 1.8 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain PA PF02225.22 VDK84038.1 - 2.7e-13 49.7 0.0 6.2e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 VDK84038.1 - 0.00037 20.0 0.0 0.0009 18.8 0.0 1.6 1 0 0 1 1 1 1 Nicastrin Baculo_11_kDa PF06143.11 VDK84038.1 - 0.0096 15.5 0.1 0.022 14.4 0.1 1.6 1 0 0 1 1 1 1 Baculovirus 11 kDa family tRNA_anti-like PF12869.7 VDK84038.1 - 0.011 15.4 0.1 0.026 14.2 0.1 1.5 1 0 0 1 1 1 0 tRNA_anti-like ODV-E18 PF10717.9 VDK84038.1 - 0.011 15.5 0.2 0.025 14.5 0.2 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ABC2_membrane_3 PF12698.7 VDK84038.1 - 0.058 12.5 0.1 0.095 11.8 0.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Actin PF00022.19 VDK84048.1 - 3.4e-111 371.7 0.0 2.4e-110 369.0 0.0 1.8 1 1 0 1 1 1 1 Actin Peptidase_M16_M PF16187.5 VDK84049.1 - 7.9e-81 271.4 6.4 7.9e-81 271.4 6.4 1.6 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 VDK84049.1 - 5.6e-41 140.0 0.0 1.4e-40 138.7 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 VDK84049.1 - 8e-32 110.7 0.0 3.3e-20 72.9 0.0 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain Toxin-deaminase PF14424.6 VDK84049.1 - 0.061 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases DUF2779 PF11074.8 VDK84049.1 - 0.073 13.5 0.4 0.35 11.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function(DUF2779) PH PF00169.29 VDK84050.1 - 4.2e-14 52.9 0.2 1.4e-13 51.2 0.2 2.0 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 VDK84050.1 - 0.013 15.8 1.8 0.04 14.2 1.8 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Mucin PF01456.17 VDK84050.1 - 0.013 15.4 48.7 0.033 14.2 48.7 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein RsgA_N PF16745.5 VDK84050.1 - 0.58 9.9 1.7 13 5.7 0.6 2.4 2 0 0 2 2 2 0 RsgA N-terminal domain DUF2407 PF10302.9 VDK84050.1 - 1.1 9.9 5.4 3.6 8.2 4.5 2.5 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF1664 PF07889.12 VDK84050.1 - 4 7.5 18.4 3.8 7.6 10.5 3.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) adh_short PF00106.25 VDK84051.1 - 1.3e-33 116.2 0.0 1.7e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK84051.1 - 5.5e-23 81.7 0.0 7.6e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 VDK84051.1 - 0.13 11.6 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) zf-CHCC PF10276.9 VDK84061.1 - 7.9e-18 64.2 3.0 1.3e-17 63.6 3.0 1.3 1 0 0 1 1 1 1 Zinc-finger domain Pkinase PF00069.25 VDK84062.1 - 2.9e-46 158.0 0.6 2.9e-46 158.0 0.6 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84062.1 - 2.5e-22 79.4 0.1 6.1e-22 78.1 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 VDK84062.1 - 0.0035 16.4 0.1 0.007 15.4 0.1 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase G-patch PF01585.23 VDK84063.1 - 1.3e-15 57.0 1.3 2.9e-15 55.9 1.3 1.6 1 0 0 1 1 1 1 G-patch domain OCRE PF17780.1 VDK84063.1 - 4e-15 55.6 10.2 8.8e-15 54.5 10.2 1.6 1 0 0 1 1 1 1 OCRE domain G-patch_2 PF12656.7 VDK84063.1 - 3.4e-10 39.9 0.2 8.7e-10 38.6 0.2 1.7 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 VDK84063.1 - 5.2e-07 29.4 0.0 0.015 15.1 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer PF06495.11 VDK84063.1 - 0.011 15.8 26.7 0.03 14.4 26.7 1.7 1 0 0 1 1 1 0 Fruit fly transformer protein zf-RanBP PF00641.18 VDK84063.1 - 0.014 14.7 5.4 0.038 13.3 5.4 1.7 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zf-C2H2_jaz PF12171.8 VDK84063.1 - 0.1 12.9 0.2 0.25 11.7 0.2 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 VDK84063.1 - 0.22 11.3 1.4 0.68 9.7 1.4 1.9 1 0 0 1 1 1 0 zinc-finger C2H2-type Homeodomain PF00046.29 VDK84067.1 - 6e-22 77.2 2.0 9.2e-22 76.6 2.0 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK84067.1 - 0.0073 16.2 0.0 0.023 14.6 0.0 1.9 1 0 0 1 1 1 1 Homeobox KN domain UCR_Fe-S_N PF10399.9 VDK84067.1 - 0.61 9.5 3.1 1.3 8.4 3.1 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal His_Phos_2 PF00328.22 VDK84071.1 - 6e-31 108.2 0.1 8.4e-28 97.8 0.1 2.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) COesterase PF00135.28 VDK84072.1 - 3.4e-130 435.3 0.0 3.9e-130 435.1 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 VDK84072.1 - 3.7e-10 40.0 0.7 4e-09 36.6 0.7 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold zf-CCCH PF00642.24 VDK84073.1 - 2.7e-15 55.8 19.9 2e-08 34.0 2.7 2.9 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK84073.1 - 1.2e-06 28.4 20.2 0.00064 19.7 6.0 2.7 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 VDK84073.1 - 0.013 16.2 4.1 0.99 10.1 0.4 2.4 2 0 0 2 2 2 0 Torus domain zf-CCCH_4 PF18044.1 VDK84073.1 - 1.9 8.4 14.2 0.39 10.6 2.2 2.8 2 0 0 2 2 2 0 CCCH-type zinc finger zf-CCCH PF00642.24 VDK84075.1 - 1e-15 57.1 8.3 1.2e-09 37.9 2.2 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK84075.1 - 1.4e-09 37.6 8.1 7.1e-05 22.7 3.0 2.7 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 VDK84075.1 - 6.7e-08 32.1 7.4 0.002 17.9 1.7 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 VDK84075.1 - 0.0028 18.3 5.9 0.043 14.5 1.0 2.5 1 1 1 2 2 2 2 Torus domain zf-CCCH_2 PF14608.6 VDK84075.1 - 0.0033 17.9 6.3 1 10.0 2.2 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Ank_2 PF12796.7 VDK84078.1 - 9.1e-36 122.3 1.3 6.5e-09 36.3 0.3 5.7 3 1 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK84078.1 - 4.5e-25 87.7 8.3 0.00019 21.9 0.0 8.0 4 2 5 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK84078.1 - 8.7e-19 65.7 13.0 0.035 14.6 0.4 10.9 11 0 0 11 11 11 5 Ankyrin repeat Ank PF00023.30 VDK84078.1 - 1.5e-15 56.8 15.8 0.051 14.0 0.0 9.5 9 1 1 10 10 10 4 Ankyrin repeat Ank_5 PF13857.6 VDK84078.1 - 2e-12 47.0 12.1 0.0042 17.4 0.0 8.2 3 1 7 10 10 10 5 Ankyrin repeats (many copies) SOCS_box PF07525.16 VDK84078.1 - 1.1e-07 32.1 0.7 2.9e-07 30.7 0.7 1.8 1 0 0 1 1 1 1 SOCS box Viral_Beta_CD PF04530.12 VDK84080.1 - 0.013 15.8 0.4 0.019 15.2 0.4 1.3 1 0 0 1 1 1 0 Viral Beta C/D like family ASFV_J13L PF05568.11 VDK84080.1 - 0.33 10.7 2.0 0.47 10.2 2.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein SUR7 PF06687.12 VDK84080.1 - 0.36 10.4 5.4 0.16 11.6 2.8 1.6 2 0 0 2 2 2 0 SUR7/PalI family Syndecan PF01034.20 VDK84080.1 - 1.5 8.8 5.9 3 7.8 5.9 1.5 1 0 0 1 1 1 0 Syndecan domain Malectin PF11721.8 VDK84083.1 - 2e-38 132.1 0.0 3.8e-38 131.2 0.0 1.5 1 0 0 1 1 1 1 Malectin domain Helicase_C PF00271.31 VDK84083.1 - 1.4e-18 67.3 0.0 3.5e-16 59.5 0.0 3.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK84083.1 - 1.9e-18 66.8 0.0 4.3e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HTH_40 PF14493.6 VDK84083.1 - 3.6e-11 43.4 0.0 1e-10 41.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain RQC PF09382.10 VDK84083.1 - 6e-10 38.9 0.0 1.4e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 VDK84083.1 - 6.3e-07 29.3 0.0 3.4e-06 27.0 0.0 2.4 3 0 0 3 3 3 1 HRDC domain ResIII PF04851.15 VDK84083.1 - 1.8e-05 24.8 0.0 4.6e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Malectin_like PF12819.7 VDK84083.1 - 0.027 13.6 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 Malectin-like domain SecA_DEAD PF07517.14 VDK84083.1 - 0.12 11.7 0.0 0.92 8.7 0.0 2.3 3 0 0 3 3 3 0 SecA DEAD-like domain SH3_19 PF18597.1 VDK84083.1 - 0.18 11.6 0.1 0.48 10.3 0.1 1.7 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain CPG4 PF15481.6 VDK84083.1 - 1.6 9.4 5.1 1.5 9.5 1.4 2.8 3 1 0 3 3 3 0 Chondroitin proteoglycan 4 NNMT_PNMT_TEMT PF01234.17 VDK84084.1 - 1.1e-10 41.1 0.6 1e-08 34.7 0.6 2.0 1 1 0 1 1 1 1 NNMT/PNMT/TEMT family WD40 PF00400.32 VDK84085.1 - 0.00024 21.9 3.1 1.2 10.1 0.1 5.0 4 0 0 4 4 4 2 WD domain, G-beta repeat zf-CCCH PF00642.24 VDK84086.1 - 2.2e-06 27.4 4.5 5e-06 26.3 4.5 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK84086.1 - 0.00085 19.3 7.2 0.0016 18.4 7.2 1.5 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 VDK84086.1 - 0.0027 18.4 0.7 0.0083 16.8 0.7 1.9 1 0 0 1 1 1 1 Torus domain zf-CCCH_4 PF18044.1 VDK84086.1 - 0.015 15.1 4.2 0.027 14.3 4.2 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger V-SNARE_C PF12352.8 VDK84087.1 - 3.9e-09 36.7 0.2 1.6e-08 34.7 0.2 2.1 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus DUF3347 PF11827.8 VDK84087.1 - 0.0022 18.2 0.4 2.1 8.5 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3347) ING PF12998.7 VDK84087.1 - 0.0026 18.3 3.9 0.032 14.8 1.0 2.3 1 1 1 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding APG17 PF04108.12 VDK84087.1 - 0.017 14.3 0.6 0.017 14.3 0.6 2.1 1 1 0 2 2 2 0 Autophagy protein Apg17 TipAS PF07739.13 VDK84087.1 - 0.024 15.2 0.2 0.12 12.9 0.2 2.1 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain FliD_N PF02465.18 VDK84087.1 - 0.026 15.2 2.5 0.47 11.2 1.3 2.5 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus T3SSipB PF16535.5 VDK84087.1 - 0.035 14.6 0.4 2.1 8.8 0.0 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB DUF1664 PF07889.12 VDK84087.1 - 0.063 13.3 1.7 1.8 8.6 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sad1_UNC PF07738.13 VDK84087.1 - 0.065 13.3 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal BLOC1_2 PF10046.9 VDK84087.1 - 0.084 13.2 2.5 0.14 12.4 0.2 2.4 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_9 PF12781.7 VDK84088.1 - 5.6e-72 241.4 5.6 8.8e-72 240.8 0.0 3.4 3 0 0 3 3 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 VDK84088.1 - 4.7e-69 232.6 0.0 1.1e-68 231.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 VDK84088.1 - 9.8e-44 149.8 0.5 9.8e-44 149.8 0.5 1.9 2 0 0 2 2 1 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 VDK84088.1 - 1.9e-41 141.6 0.0 6.1e-39 133.4 0.0 2.9 3 0 0 3 3 3 1 P-loop containing dynein motor region MT PF12777.7 VDK84088.1 - 6.2e-38 130.7 3.8 1e-37 130.0 3.8 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 VDK84088.1 - 1.8e-35 122.2 0.0 3.8e-35 121.1 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 VDK84088.1 - 1.6e-27 96.0 0.0 3.7e-26 91.5 0.0 3.2 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 VDK84088.1 - 2.9e-15 56.5 0.0 1.4e-06 28.3 0.0 3.4 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 VDK84088.1 - 7e-12 45.8 0.2 8.6e-05 22.8 0.0 4.7 4 1 0 4 4 3 2 AAA domain AAA PF00004.29 VDK84088.1 - 1.3e-11 45.0 0.0 0.00036 21.0 0.0 3.5 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 VDK84088.1 - 6.2e-07 28.7 0.0 0.011 14.8 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_19 PF13245.6 VDK84088.1 - 6.4e-06 26.6 0.2 0.015 15.6 0.0 3.8 2 1 1 3 3 3 1 AAA domain AAA_18 PF13238.6 VDK84088.1 - 1.8e-05 25.3 0.0 0.14 12.7 0.0 3.3 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 VDK84088.1 - 2.4e-05 24.4 0.0 0.19 11.7 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_lid_1 PF17857.1 VDK84088.1 - 0.0001 22.4 0.0 0.00067 19.8 0.0 2.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_33 PF13671.6 VDK84088.1 - 0.00019 21.6 1.4 1 9.5 0.1 3.5 4 0 0 4 4 2 2 AAA domain AAA_16 PF13191.6 VDK84088.1 - 0.00026 21.4 5.2 0.69 10.3 0.1 4.5 4 1 0 5 5 3 2 AAA ATPase domain FtsK_SpoIIIE PF01580.18 VDK84088.1 - 0.00077 18.9 0.0 0.044 13.1 0.0 2.6 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.6 VDK84088.1 - 0.00086 19.0 0.1 0.1 12.4 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 VDK84088.1 - 0.00088 18.9 0.8 0.059 12.9 0.0 3.0 3 0 0 3 3 2 1 AAA domain Mg_chelatase PF01078.21 VDK84088.1 - 0.0016 17.9 0.0 0.75 9.1 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 VDK84088.1 - 0.0023 18.4 1.6 3.2 8.3 0.0 3.7 4 0 0 4 4 2 1 ABC transporter AAA_30 PF13604.6 VDK84088.1 - 0.0049 16.6 0.0 5.1 6.8 0.0 3.5 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 VDK84088.1 - 0.0059 16.3 0.0 0.14 11.9 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein Rad17 PF03215.15 VDK84088.1 - 0.0067 16.4 0.0 6.4 6.7 0.0 2.7 2 0 0 2 2 2 0 Rad17 P-loop domain BRE1 PF08647.11 VDK84088.1 - 0.0076 16.3 2.1 0.0076 16.3 2.1 3.6 3 1 1 4 4 2 1 BRE1 E3 ubiquitin ligase RsgA_GTPase PF03193.16 VDK84088.1 - 0.014 15.3 1.1 3.5 7.5 0.0 3.2 3 0 0 3 3 3 0 RsgA GTPase AAA_28 PF13521.6 VDK84088.1 - 0.014 15.6 1.1 5 7.3 0.0 3.3 3 0 0 3 3 2 0 AAA domain RuvB_N PF05496.12 VDK84088.1 - 0.02 14.7 0.0 0.51 10.1 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 VDK84088.1 - 0.028 14.3 0.5 22 4.9 0.0 3.7 4 0 0 4 4 3 0 NACHT domain AAA_21 PF13304.6 VDK84088.1 - 0.041 13.7 0.0 6.6 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 VDK84088.1 - 0.062 13.0 0.0 13 5.4 0.0 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 VDK84088.1 - 0.17 11.5 0.5 3 7.4 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.6 VDK84088.1 - 0.28 10.9 0.0 0.28 10.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain Taxilin PF09728.9 VDK84088.1 - 0.35 10.0 25.9 0.13 11.5 21.6 2.2 2 1 0 2 2 1 0 Myosin-like coiled-coil protein DUF948 PF06103.11 VDK84088.1 - 0.74 10.1 10.0 8.2 6.8 0.1 4.0 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) FapA PF03961.13 VDK84088.1 - 0.74 8.4 24.5 0.31 9.6 0.6 3.1 3 0 0 3 3 3 0 Flagellar Assembly Protein A Fez1 PF06818.15 VDK84088.1 - 2.7 8.4 27.5 2.8 8.3 1.0 3.4 3 0 0 3 3 3 0 Fez1 DUF390 PF04094.14 VDK84088.1 - 3 6.0 5.8 5.9 5.0 5.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF390) AAA_23 PF13476.6 VDK84088.1 - 4 7.9 0.0 4 7.9 0.0 4.7 5 0 0 5 5 4 0 AAA domain Glu-tRNAGln PF02686.15 VDK84092.1 - 2.2e-09 37.5 0.3 4.9e-09 36.3 0.3 1.6 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Kinesin PF00225.23 VDK84093.1 - 2.8e-107 358.5 1.2 2.8e-107 358.5 1.2 2.7 2 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 VDK84093.1 - 9e-24 84.1 1.2 3.4e-23 82.2 0.0 2.7 2 0 0 2 2 2 1 Microtubule binding Spc7 PF08317.11 VDK84093.1 - 0.00072 18.5 15.2 0.00072 18.5 15.2 3.3 2 1 1 3 3 3 1 Spc7 kinetochore protein CALCOCO1 PF07888.11 VDK84093.1 - 0.00077 18.4 20.6 0.00077 18.4 20.6 2.4 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.12 VDK84093.1 - 0.0077 16.3 13.9 0.0077 16.3 13.9 5.4 3 2 3 6 6 6 3 TPR/MLP1/MLP2-like protein PAP2_C PF14360.6 VDK84094.1 - 5e-25 87.8 11.0 5e-25 87.8 11.0 2.5 3 0 0 3 3 3 1 PAP2 superfamily C-terminal SAM_1 PF00536.30 VDK84094.1 - 2.1e-12 47.3 0.0 5e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 VDK84094.1 - 0.0001 22.2 0.1 0.0006 19.7 0.0 2.1 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 VDK84094.1 - 0.00089 19.3 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PAP2 PF01569.21 VDK84094.1 - 0.0036 17.1 12.6 0.0036 17.1 12.6 2.0 1 1 1 2 2 2 1 PAP2 superfamily SAM_3 PF18016.1 VDK84094.1 - 0.044 13.6 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2721 PF11026.8 VDK84094.1 - 0.74 9.7 5.2 6.5 6.6 0.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) ubiquitin PF00240.23 VDK84096.1 - 5.8e-170 551.4 24.0 2.8e-33 113.5 0.4 5.0 5 0 0 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 VDK84096.1 - 1.3e-79 262.0 26.2 2.8e-15 55.9 0.5 5.0 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 VDK84096.1 - 5.2e-29 100.5 12.0 0.00043 20.7 0.1 6.9 5 5 0 5 5 5 5 Ubiquitin-like domain Ubiquitin_5 PF18037.1 VDK84096.1 - 1.5e-18 66.9 10.8 0.039 14.3 0.1 5.1 1 1 3 5 5 5 5 Ubiquitin-like domain TBK1_ULD PF18396.1 VDK84096.1 - 2e-18 66.1 7.8 0.054 13.4 0.1 5.3 5 0 0 5 5 5 5 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 VDK84096.1 - 3.4e-17 62.5 5.6 0.16 12.1 0.0 6.0 5 4 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 VDK84096.1 - 5.5e-16 59.0 1.8 0.31 11.6 0.1 5.2 1 1 1 5 5 5 5 DUF2407 ubiquitin-like domain Big_7 PF17957.1 VDK84096.1 - 2.3e-12 47.5 0.2 4.6 8.1 0.0 5.2 5 0 0 5 5 5 5 Bacterial Ig domain Sde2_N_Ubi PF13019.6 VDK84096.1 - 6.3e-11 42.4 0.5 3.3 7.5 0.0 5.1 1 1 4 5 5 5 5 Silencing defective 2 N-terminal ubiquitin domain Methyltrans_RNA PF04452.14 VDK84096.1 - 3.5e-09 36.3 3.0 1.1 8.5 0.0 4.3 4 0 0 4 4 4 4 RNA methyltransferase UDP-g_GGTase PF06427.11 VDK84096.1 - 1.2e-07 31.8 6.2 6.6 6.9 0.0 5.2 5 0 0 5 5 5 4 UDP-glucose:Glycoprotein Glucosyltransferase DUF2870 PF11069.8 VDK84096.1 - 2.8e-07 30.8 0.0 43 4.6 0.0 5.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2870) Ubiquitin_4 PF18036.1 VDK84096.1 - 7.3e-07 29.2 33.8 24 5.0 0.2 9.9 10 0 0 10 10 10 0 Ubiquitin-like domain Big_3_3 PF13750.6 VDK84096.1 - 2.6e-06 27.2 0.0 28 4.3 0.0 5.0 5 0 0 5 5 5 0 Bacterial Ig-like domain (group 3) DUF3861 PF12977.7 VDK84096.1 - 3.7e-06 27.0 6.2 24 5.2 0.0 5.2 5 0 0 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3861) DUF969 PF06149.12 VDK84096.1 - 3.5e-05 23.3 0.2 33 3.8 0.0 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF969) PDGLE PF13190.6 VDK84096.1 - 0.00029 20.7 10.8 25 4.8 0.1 5.8 1 1 2 5 5 5 0 PDGLE domain ACT_5 PF13710.6 VDK84096.1 - 0.00055 19.7 6.0 37 4.3 0.1 5.2 5 0 0 5 5 5 0 ACT domain ORF11CD3 PF10549.9 VDK84096.1 - 0.00059 19.9 0.0 1.3e+02 2.8 0.0 5.6 5 0 0 5 5 5 0 ORF11CD3 domain ACT_4 PF13291.6 VDK84096.1 - 0.002 18.7 2.2 1.7e+02 2.9 0.0 5.1 5 0 0 5 5 5 0 ACT domain ProRS-C_2 PF09181.10 VDK84096.1 - 0.041 14.0 9.1 1.1e+02 3.0 0.1 5.2 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal Baculo_p48 PF04878.13 VDK84096.1 - 0.12 11.3 0.0 1.4e+02 1.2 0.0 3.7 4 0 0 4 4 4 0 Baculovirus P48 protein FlgD_ig PF13860.6 VDK84096.1 - 1.5 8.8 12.8 1.3e+02 2.6 0.1 5.2 5 0 0 5 5 5 0 FlgD Ig-like domain YcgR_2 PF12945.7 VDK84096.1 - 2.7 8.2 6.5 3.9e+02 1.3 0.0 4.8 5 0 0 5 5 5 0 Flagellar protein YcgR Phage_sheath_1N PF17481.2 VDK84096.1 - 5.5 7.5 10.5 1.3e+02 3.1 0.8 4.6 1 1 0 2 2 2 0 Phage tail sheath protein beta-sandwich domain Xpo1 PF08389.12 VDK84097.1 - 5.7e-10 39.4 0.6 5.7e-10 39.4 0.6 4.8 5 1 1 6 6 6 2 Exportin 1-like protein Importin_rep_3 PF18806.1 VDK84097.1 - 1.4e-05 25.1 0.5 0.0002 21.3 0.1 3.0 3 1 0 3 3 3 1 Importin 13 repeat Hydrolase_4 PF12146.8 VDK84105.1 - 0.009 15.3 0.0 0.038 13.2 0.0 2.1 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Colipase PF01114.18 VDK84106.1 - 0.077 12.7 10.6 0.59 9.8 1.9 2.4 2 0 0 2 2 2 0 Colipase, N-terminal domain OSTMP1 PF09777.9 VDK84108.1 - 3.3e-34 118.3 18.0 7.1e-28 97.6 5.5 2.5 2 1 1 3 3 3 2 Osteopetrosis-associated transmembrane protein 1 precursor UCR_hinge PF02320.16 VDK84108.1 - 4e-17 62.2 2.7 4e-17 62.2 2.7 2.6 3 0 0 3 3 3 1 Ubiquinol-cytochrome C reductase hinge protein zf-AD PF07776.15 VDK84108.1 - 6.8 7.0 8.4 1.4 9.2 0.3 3.0 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) SCO1-SenC PF02630.14 VDK84109.1 - 4.2e-47 159.4 0.0 6.4e-47 158.8 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 VDK84109.1 - 0.001 19.3 0.3 0.0028 17.9 0.1 2.0 2 1 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 VDK84109.1 - 0.012 15.5 0.1 0.027 14.4 0.1 1.7 1 1 0 1 1 1 0 AhpC/TSA family TFIIF_alpha PF05793.12 VDK84110.1 - 1.2e-103 347.5 43.4 1e-101 341.2 43.4 2.0 1 1 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SNF PF00209.18 VDK84111.1 - 4.1e-10 39.0 5.8 4.7e-10 38.8 5.8 1.0 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Mito_carr PF00153.27 VDK84119.1 - 6.9e-39 131.7 1.5 8.8e-20 70.4 0.2 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Mito_carr PF00153.27 VDK84120.1 - 4.6e-18 64.9 0.2 8.1e-17 60.9 0.2 2.0 1 1 0 1 1 1 1 Mitochondrial carrier protein Neur_chan_memb PF02932.16 VDK84121.1 - 0.037 14.1 1.2 0.046 13.8 1.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DAGK_cat PF00781.24 VDK84122.1 - 2e-11 43.6 0.0 3.1e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain EloA-BP1 PF15870.5 VDK84123.1 - 2.6e-30 105.9 0.0 2.6e-30 105.9 0.0 3.6 2 1 0 3 3 3 1 ElonginA binding-protein 1 PGM_PMM_I PF02878.16 VDK84125.1 - 1.5e-32 112.1 0.0 2.4e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 VDK84125.1 - 5.5e-30 103.9 0.0 9.1e-30 103.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 VDK84125.1 - 7.2e-17 61.9 0.0 1.5e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 VDK84125.1 - 1.6e-06 28.2 0.0 3.3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain HMG-CoA_red PF00368.18 VDK84125.1 - 0.058 12.4 0.0 0.092 11.7 0.0 1.2 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A reductase Ribosomal_L37e PF01907.19 VDK84127.1 - 2.3e-28 98.1 12.8 4.1e-28 97.3 12.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 VDK84127.1 - 0.018 15.1 1.5 0.029 14.4 1.5 1.3 1 0 0 1 1 1 0 Double zinc ribbon SelR PF01641.18 VDK84127.1 - 0.027 14.5 0.4 0.03 14.4 0.4 1.1 1 0 0 1 1 1 0 SelR domain DUF1462 PF07315.11 VDK84127.1 - 0.16 12.3 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) DUF1258 PF06869.12 VDK84127.1 - 0.18 11.3 1.0 0.23 10.9 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) DUF35_N PF12172.8 VDK84127.1 - 0.22 11.5 4.6 0.47 10.4 4.6 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HypA PF01155.19 VDK84127.1 - 0.45 10.5 2.5 0.64 10.1 2.2 1.4 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 VDK84127.1 - 0.64 9.8 4.8 3 7.7 0.6 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain zn-ribbon_14 PF16503.5 VDK84127.1 - 0.72 9.4 5.2 1.5 8.3 0.3 2.2 2 0 0 2 2 2 0 Zinc-ribbon Globin PF00042.22 VDK84133.1 - 1.6e-07 31.8 0.0 2.1e-05 25.1 0.0 2.3 1 1 0 1 1 1 1 Globin Y_phosphatase PF00102.27 VDK84134.1 - 1.5e-26 93.4 0.1 2.8e-25 89.3 0.1 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase EF-hand_1 PF00036.32 VDK84136.1 - 3.5e-38 126.3 9.9 8.1e-10 37.5 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 VDK84136.1 - 5.8e-33 113.2 2.1 9.6e-16 58.0 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 VDK84136.1 - 6.1e-30 102.8 9.4 3e-13 49.4 0.1 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 VDK84136.1 - 1.5e-27 93.1 5.2 1.4e-09 37.1 0.1 4.5 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 VDK84136.1 - 8.2e-25 85.2 7.3 7.9e-07 28.3 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 VDK84136.1 - 1.4e-13 50.9 0.1 2.5e-09 37.3 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 VDK84136.1 - 1.5e-06 28.1 0.2 0.054 13.5 0.1 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDK84136.1 - 5e-06 26.8 0.0 0.063 13.6 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 VDK84136.1 - 2.1e-05 24.4 0.0 0.045 13.8 0.0 2.8 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 VDK84136.1 - 4.8e-05 24.2 0.0 0.019 15.8 0.0 2.0 1 1 1 2 2 2 2 EF-hand domain EFhand_Ca_insen PF08726.10 VDK84136.1 - 0.00031 20.8 0.2 0.001 19.1 0.0 1.9 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 VDK84136.1 - 0.00079 19.6 5.1 0.11 12.7 0.5 3.1 1 1 2 3 3 3 2 Dockerin type I domain Caleosin PF05042.13 VDK84136.1 - 0.0021 18.0 0.3 0.57 10.1 0.0 3.0 1 1 2 3 3 3 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 VDK84136.1 - 0.0049 17.2 1.1 1.7 9.0 0.1 2.5 3 0 0 3 3 3 1 RNA polymerase Rpb4 DUF1103 PF06513.11 VDK84136.1 - 0.0054 16.4 1.8 0.0064 16.1 1.8 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) MotA_activ PF09114.10 VDK84136.1 - 0.0097 16.0 0.6 0.12 12.5 0.1 2.3 1 1 0 2 2 2 1 Transcription factor MotA, activation domain DUF4497 PF14924.6 VDK84136.1 - 0.011 16.2 0.0 1.6 9.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4497) TerB PF05099.13 VDK84136.1 - 0.011 15.7 0.3 0.65 9.9 0.0 2.1 1 1 1 2 2 2 0 Tellurite resistance protein TerB dCache_2 PF08269.11 VDK84136.1 - 0.016 14.4 0.1 0.95 8.6 0.0 2.2 1 1 0 2 2 2 0 Cache domain Poly_export PF02563.16 VDK84136.1 - 0.019 15.2 0.1 0.93 9.8 0.0 2.9 2 2 1 3 3 3 0 Polysaccharide biosynthesis/export protein SurA_N_2 PF13623.6 VDK84136.1 - 0.059 13.2 0.4 3.1 7.7 0.1 2.2 1 1 1 2 2 2 0 SurA N-terminal domain Fe_hyd_lg_C PF02906.14 VDK84136.1 - 0.09 12.4 0.2 0.3 10.7 0.2 1.8 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain EF-hand_14 PF17959.1 VDK84136.1 - 0.091 13.1 0.1 9.9 6.6 0.0 2.3 1 1 1 2 2 2 0 EF-hand domain TetR_C_7 PF14246.6 VDK84136.1 - 0.11 12.6 0.0 8.4 6.5 0.0 2.6 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain RuvA_C PF07499.13 VDK84136.1 - 0.17 12.4 0.1 14 6.3 0.0 2.9 3 0 0 3 3 3 0 RuvA, C-terminal domain Laminin_I PF06008.14 VDK84137.1 - 0.0049 16.6 0.8 0.0063 16.2 0.8 1.0 1 0 0 1 1 1 1 Laminin Domain I DivIVA PF05103.13 VDK84137.1 - 0.016 15.3 1.4 0.12 12.4 1.4 2.1 1 1 0 1 1 1 0 DivIVA protein KASH_CCD PF14662.6 VDK84137.1 - 0.016 15.0 2.3 0.031 14.1 2.3 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Seryl_tRNA_N PF02403.22 VDK84137.1 - 0.055 13.7 1.2 0.08 13.2 1.2 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.8 VDK84137.1 - 0.057 12.7 0.3 0.073 12.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) MerR-DNA-bind PF09278.11 VDK84137.1 - 0.075 13.6 0.9 0.26 11.9 0.5 2.0 1 1 2 3 3 3 0 MerR, DNA binding HAUS-augmin3 PF14932.6 VDK84137.1 - 0.091 12.3 0.8 0.13 11.8 0.8 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 VDK84137.1 - 0.1 11.4 2.7 0.14 11.0 2.7 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 VDK84137.1 - 0.14 12.8 0.8 0.59 10.8 0.1 2.1 1 1 2 3 3 3 0 SlyX FlaC_arch PF05377.11 VDK84137.1 - 0.15 12.5 1.4 0.73 10.3 0.5 2.2 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Mic1 PF07035.12 VDK84139.1 - 2e-35 121.9 3.1 4e-35 120.8 3.1 1.5 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like Frigida PF07899.11 VDK84139.1 - 0.0049 16.2 0.0 0.0086 15.4 0.0 1.3 1 0 0 1 1 1 1 Frigida-like protein wnt PF00110.19 VDK84155.1 - 4.2e-112 374.7 26.5 4.9e-112 374.5 26.5 1.0 1 0 0 1 1 1 1 wnt family Glyco_transf_43 PF03360.16 VDK84156.1 - 5.9e-56 189.6 0.0 7.5e-56 189.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 43 Y_phosphatase PF00102.27 VDK84166.1 - 6e-13 48.9 0.3 6e-13 48.9 0.3 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DUF2839 PF10999.8 VDK84166.1 - 0.24 11.8 0.1 0.24 11.8 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2839) DUF4048 PF13257.6 VDK84166.1 - 0.37 10.6 13.1 0.63 9.8 13.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) Presenilin PF01080.17 VDK84166.1 - 0.86 8.3 8.7 0.93 8.2 8.7 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 VDK84166.1 - 0.99 7.6 10.6 1 7.6 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF5421 PF17458.2 VDK84166.1 - 1.1 8.5 8.0 1.5 8.1 8.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) EFTUD2 PF16004.5 VDK84166.1 - 1.8 9.2 8.5 1.1 9.8 5.1 2.3 1 1 1 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Neur_chan_memb PF02932.16 VDK84166.1 - 3.8 7.5 5.4 4.5 7.3 5.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ORC_WH_C PF18137.1 VDK84166.1 - 8.4 6.5 14.7 0.15 12.1 5.5 2.1 1 1 1 2 2 2 0 Origin recognition complex winged helix C-terminal ATP-grasp_2 PF08442.10 VDK84167.1 - 4.6e-71 238.6 0.1 9.9e-71 237.5 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 VDK84167.1 - 6.4e-23 81.3 2.2 1.3e-22 80.3 2.2 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 VDK84167.1 - 2.6e-05 23.8 0.0 0.00026 20.5 0.0 2.7 1 1 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 VDK84167.1 - 0.021 14.6 0.0 0.06 13.1 0.0 1.8 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain OKR_DC_1_N PF03709.15 VDK84167.1 - 0.089 13.1 0.2 0.23 11.8 0.2 1.7 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain RXT2_N PF08595.11 VDK84167.1 - 6 6.9 10.1 2.9 7.9 7.5 1.8 1 1 1 2 2 2 0 RXT2-like, N-terminal Peptidase_M17 PF00883.21 VDK84168.1 - 8.4e-96 320.9 0.0 1.2e-95 320.4 0.0 1.2 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Pdase_M17_N2 PF18295.1 VDK84168.1 - 5.2e-08 33.2 0.0 9.3e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 M17 aminopeptidase N-terminal domain 2 DUF4470 PF14737.6 VDK84168.1 - 0.046 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) fn3 PF00041.21 VDK84171.1 - 0.00017 21.9 0.1 0.9 9.9 0.0 2.4 2 0 0 2 2 2 2 Fibronectin type III domain Interfer-bind PF09294.10 VDK84171.1 - 0.051 13.9 0.0 0.096 13.0 0.0 1.4 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III Vwaint PF14624.6 VDK84172.1 - 0.0071 16.5 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 VWA / Hh protein intein-like fn3 PF00041.21 VDK84172.1 - 0.026 14.9 0.0 0.046 14.1 0.0 1.4 1 0 0 1 1 1 0 Fibronectin type III domain Cation_ATPase_C PF00689.21 VDK84177.1 - 2.2e-31 109.0 2.3 3.2e-31 108.4 2.3 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 VDK84177.1 - 4.3e-14 53.3 0.0 1.1e-08 35.6 0.0 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 VDK84177.1 - 6.2e-05 22.9 0.2 0.23 11.2 0.2 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF4345 PF14248.6 VDK84177.1 - 0.29 11.0 3.7 1.8 8.5 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4345) E1-E2_ATPase PF00122.20 VDK84178.1 - 3.5e-34 117.9 1.8 3.5e-34 117.9 1.8 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 VDK84178.1 - 3.2e-14 52.8 0.0 6.6e-14 51.8 0.0 1.7 1 1 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 VDK84178.1 - 1.5e-09 37.4 0.1 1.6e-08 34.1 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Acyl_transf_3 PF01757.22 VDK84178.1 - 0.011 14.9 1.4 0.011 14.9 1.4 2.0 2 0 0 2 2 2 0 Acyltransferase family Hydrolase PF00702.26 VDK84178.1 - 0.011 16.0 0.0 0.043 14.1 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase AOX PF01786.17 VDK84178.1 - 0.041 13.5 0.1 0.11 12.0 0.0 1.7 1 1 0 1 1 1 0 Alternative oxidase DUF3784 PF12650.7 VDK84178.1 - 2.4 8.4 13.8 2.1 8.6 4.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) DUF4131 PF13567.6 VDK84178.1 - 2.4 7.8 4.7 0.3 10.7 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DHHC PF01529.20 VDK84178.1 - 7.4 6.7 14.1 13 5.8 5.4 2.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF2207 PF09972.9 VDK84178.1 - 9.4 4.9 9.3 1.1 8.0 0.5 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ashwin PF15323.6 VDK84186.1 - 0.18 11.8 11.2 0.21 11.6 11.2 1.2 1 0 0 1 1 1 0 Developmental protein PI3K_1B_p101 PF10486.9 VDK84186.1 - 5 4.8 12.1 5.8 4.6 12.1 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LRR_8 PF13855.6 VDK84187.1 - 6e-57 189.3 41.3 1.2e-08 34.5 5.3 9.8 5 3 5 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 VDK84187.1 - 8.2e-40 134.2 57.9 6e-08 32.9 2.3 10.7 9 3 3 12 12 12 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK84187.1 - 5.2e-10 38.5 42.2 2.9 8.8 0.2 15.1 15 3 0 15 15 15 5 Leucine Rich Repeat LRR_9 PF14580.6 VDK84187.1 - 5.1e-08 32.6 28.4 0.009 15.5 0.3 5.8 1 1 5 7 7 7 6 Leucine-rich repeat LRR_5 PF13306.6 VDK84187.1 - 4.8e-06 26.6 0.2 0.019 15.0 0.1 4.0 2 1 1 4 4 4 2 BspA type Leucine rich repeat region (6 copies) DUF2322 PF10084.9 VDK84187.1 - 0.04 14.0 1.2 30 4.7 0.0 3.8 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2322) DUF1118 PF06549.12 VDK84187.1 - 0.11 12.9 0.1 0.36 11.2 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) LRR_6 PF13516.6 VDK84187.1 - 0.53 10.5 50.2 0.3 11.2 0.5 12.9 15 0 0 15 15 15 0 Leucine Rich repeat SNF2_N PF00176.23 VDK84188.1 - 8.4e-41 139.8 0.0 1.7e-40 138.9 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK84188.1 - 6.6e-14 52.2 0.0 1.5e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 VDK84188.1 - 0.00033 19.9 0.1 0.0035 16.6 0.0 2.4 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DUF2439 PF10382.9 VDK84188.1 - 0.022 15.1 0.0 0.066 13.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) ResIII PF04851.15 VDK84188.1 - 0.052 13.5 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Vps26 PF03643.15 VDK84190.1 - 4.1e-125 416.3 4.8 5.5e-125 415.9 4.8 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Sulfotransfer_1 PF00685.27 VDK84190.1 - 2.7e-20 73.0 0.0 5.1e-19 68.8 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 VDK84190.1 - 1.7e-05 25.3 0.2 7.5e-05 23.2 0.2 1.9 1 1 0 1 1 1 1 Sulfotransferase family Arrestin_N PF00339.29 VDK84190.1 - 0.00012 22.2 0.6 0.024 14.7 0.0 3.3 3 1 1 4 4 4 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 VDK84190.1 - 0.00028 21.3 0.0 0.19 12.2 0.0 3.3 3 1 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Sulfotransfer_2 PF03567.14 VDK84190.1 - 0.025 14.5 0.0 0.047 13.6 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase family HTH_28 PF13518.6 VDK84190.1 - 0.061 13.5 0.4 0.15 12.2 0.4 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HMG_box PF00505.19 VDK84194.1 - 3.2e-24 85.1 2.0 5.4e-24 84.4 2.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK84194.1 - 2.1e-09 37.8 0.8 4.1e-09 36.9 0.8 1.4 1 0 0 1 1 1 1 HMG-box domain DM13 PF10517.9 VDK84196.1 - 4.7e-34 117.1 0.0 4.1e-18 65.9 0.0 2.7 2 0 0 2 2 2 2 Electron transfer DM13 DM13 PF10517.9 VDK84197.1 - 4.3e-15 56.2 1.0 6.5e-08 33.1 0.0 3.7 2 1 2 4 4 4 2 Electron transfer DM13 DUF4005 PF13178.6 VDK84197.1 - 0.13 12.9 0.1 0.31 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4005) DUF5600 PF18150.1 VDK84203.1 - 1.2e-15 58.0 2.1 1.2e-15 58.0 2.1 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF5600) MMR_HSR1 PF01926.23 VDK84203.1 - 3.5e-08 33.5 0.0 1.1e-07 31.9 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 VDK84203.1 - 7.9e-08 32.5 4.3 2.4e-07 30.9 0.0 2.9 2 1 0 2 2 2 1 Dynamin family EHD_N PF16880.5 VDK84203.1 - 6.7e-05 22.7 1.1 6.7e-05 22.7 1.1 1.8 2 0 0 2 2 2 1 N-terminal EH-domain containing protein Gtr1_RagA PF04670.12 VDK84203.1 - 0.0041 16.5 0.8 0.73 9.1 0.1 2.6 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 VDK84203.1 - 0.011 16.0 0.1 2.7 8.2 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 VDK84203.1 - 0.046 13.6 0.1 9 6.2 0.0 2.7 2 1 0 2 2 2 0 RsgA GTPase GTP_EFTU PF00009.27 VDK84203.1 - 0.05 13.1 1.2 0.15 11.5 0.7 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain UQ_con PF00179.26 VDK84204.1 - 4.2e-47 159.3 0.0 4.8e-47 159.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme HisKA PF00512.25 VDK84205.1 - 0.02 14.9 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain T3SS_needle_E PF08988.10 VDK84205.1 - 0.05 13.8 1.4 13 6.0 0.1 3.0 2 1 1 3 3 3 0 Type III secretion system, cytoplasmic E component of needle HTH_24 PF13412.6 VDK84205.1 - 0.079 12.5 0.1 0.23 11.1 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TrmB PF01978.19 VDK84205.1 - 0.14 12.1 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Thioredoxin PF00085.20 VDK84206.1 - 3.5e-17 62.3 0.9 2.6e-16 59.5 0.2 2.3 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 VDK84206.1 - 8.6e-17 61.6 8.9 1.3e-11 44.7 1.7 2.1 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK84206.1 - 1.8e-08 34.6 1.0 0.00032 20.9 0.0 2.9 2 1 0 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 VDK84206.1 - 2.3e-05 24.1 0.3 0.00019 21.1 0.0 2.1 2 0 0 2 2 2 1 Redoxin AhpC-TSA PF00578.21 VDK84206.1 - 8.9e-05 22.4 0.8 0.00078 19.4 0.1 2.3 2 1 0 2 2 2 1 AhpC/TSA family Thioredoxin_2 PF13098.6 VDK84206.1 - 0.0017 18.8 0.9 0.0059 17.0 0.2 2.3 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 VDK84206.1 - 0.049 13.8 0.0 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like TraF PF13728.6 VDK84206.1 - 0.25 11.1 0.0 0.25 11.1 0.0 2.4 3 0 0 3 3 3 0 F plasmid transfer operon protein Kelch_1 PF01344.25 VDK84207.1 - 2.7e-84 276.5 9.7 5.4e-17 61.1 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 VDK84207.1 - 2.2e-44 148.3 1.8 1.7e-06 28.1 0.0 6.3 1 1 5 6 6 6 6 Kelch motif Kelch_2 PF07646.15 VDK84207.1 - 2e-34 116.2 7.2 2.2e-07 30.6 0.0 6.7 7 0 0 7 7 7 6 Kelch motif BTB PF00651.31 VDK84207.1 - 1.1e-30 106.2 0.1 1.7e-30 105.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 VDK84207.1 - 4.5e-30 103.8 0.3 1.2e-29 102.5 0.1 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Kelch_3 PF13415.6 VDK84207.1 - 8.3e-28 96.1 2.1 0.00038 20.7 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 VDK84207.1 - 2.4e-27 94.7 0.5 0.00018 21.4 0.0 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 VDK84207.1 - 5.5e-08 32.6 9.9 0.003 17.5 0.2 4.9 5 0 0 5 5 5 3 Kelch motif DUF3342 PF11822.8 VDK84207.1 - 9.5e-05 22.5 0.3 0.0041 17.3 0.1 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3342) YjcQ PF09639.10 VDK84207.1 - 0.043 14.0 0.0 12 6.2 0.0 3.1 3 0 0 3 3 3 0 YjcQ protein Thioredoxin PF00085.20 VDK84218.1 - 5.9e-59 196.4 0.2 2.1e-28 98.3 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 VDK84218.1 - 2.6e-24 86.2 4.7 5.1e-19 68.9 5.7 3.0 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK84218.1 - 3.7e-09 36.8 0.3 0.12 12.7 0.0 5.3 3 3 2 5 5 5 2 Thioredoxin-like Thioredoxin_2 PF13098.6 VDK84218.1 - 1.3e-08 35.2 2.6 0.00015 22.2 0.1 3.4 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 VDK84218.1 - 7.3e-08 32.5 0.1 0.012 15.8 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 VDK84218.1 - 9e-06 25.2 0.0 0.0037 16.7 0.0 3.0 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 VDK84218.1 - 9.6e-06 25.5 1.0 0.22 11.5 0.1 3.2 2 1 1 3 3 3 2 AhpC/TSA family Redoxin PF08534.10 VDK84218.1 - 0.001 18.8 0.1 1.5 8.5 0.0 2.7 3 0 0 3 3 3 2 Redoxin TraF PF13728.6 VDK84218.1 - 0.1 12.4 0.0 1.5 8.6 0.0 2.4 2 1 0 2 2 2 0 F plasmid transfer operon protein zf-H2C2_2 PF13465.6 VDK84219.1 - 8.7e-26 89.2 41.8 2.4e-07 30.9 0.1 7.7 9 0 0 9 9 8 5 Zinc-finger double domain zf-C2H2 PF00096.26 VDK84219.1 - 3e-17 62.0 43.9 0.012 16.0 0.5 7.7 7 0 0 7 7 7 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK84219.1 - 6.1e-12 45.3 42.0 0.012 16.4 0.2 7.8 7 0 0 7 7 7 6 C2H2-type zinc finger zf-RING_7 PF02591.15 VDK84219.1 - 0.00073 19.7 3.2 0.22 11.7 0.1 3.6 3 0 0 3 3 3 1 C4-type zinc ribbon domain zf-C2H2_11 PF16622.5 VDK84219.1 - 0.00079 19.1 13.2 1.1 9.1 0.1 5.1 4 0 0 4 4 4 3 zinc-finger C2H2-type TF_Zn_Ribbon PF08271.12 VDK84219.1 - 0.0059 16.1 1.5 13 5.3 0.1 4.1 3 0 0 3 3 3 0 TFIIB zinc-binding zf_C2H2_6 PF18450.1 VDK84219.1 - 0.023 14.4 10.1 0.99 9.2 0.0 5.0 5 0 0 5 5 5 0 Zinc Finger domain zinc_ribbon_12 PF11331.8 VDK84219.1 - 0.056 13.3 5.1 0.82 9.5 0.3 2.7 2 0 0 2 2 2 0 Probable zinc-ribbon domain Ribosomal_S27e PF01667.17 VDK84219.1 - 0.18 11.5 5.8 2.6 7.8 0.8 3.5 3 0 0 3 3 3 0 Ribosomal protein S27 zinc_ribbon_15 PF17032.5 VDK84219.1 - 0.98 10.2 16.0 1.4 9.7 1.7 4.3 4 0 0 4 4 4 0 zinc-ribbon family zf_C2H2_ZHX PF18387.1 VDK84219.1 - 1.3 8.7 17.3 1.8 8.3 0.1 4.6 3 1 1 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 VDK84219.1 - 2 9.1 11.6 1.7 9.3 0.4 3.9 3 2 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats DUF3268 PF11672.8 VDK84219.1 - 3.6 8.0 8.3 1.1 9.5 0.9 3.1 2 1 0 2 2 2 0 zinc-finger-containing domain zf-C2H2_jaz PF12171.8 VDK84219.1 - 8.3 6.8 8.2 55 4.2 0.0 5.0 6 0 0 6 6 6 0 Zinc-finger double-stranded RNA-binding zf-DNA_Pol PF08996.10 VDK84219.1 - 8.6 6.1 11.6 4.2 7.1 1.8 3.1 2 1 1 3 3 3 0 DNA Polymerase alpha zinc finger zf-CHCC PF10276.9 VDK84219.1 - 9.6 6.4 10.4 6.2 7.0 0.2 4.4 4 0 0 4 4 4 0 Zinc-finger domain LEM PF03020.15 VDK84220.1 - 1.8e-16 59.4 0.2 2.1e-15 56.0 0.0 2.5 3 0 0 3 3 3 1 LEM domain G-alpha PF00503.20 VDK84221.1 - 4.4e-96 322.1 1.2 5.8e-96 321.7 1.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 VDK84221.1 - 1.1e-10 41.2 0.7 4.6e-10 39.2 0.2 2.2 2 1 0 2 2 2 1 ADP-ribosylation factor family Collectrin PF16959.5 VDK84221.1 - 0.059 13.2 1.6 0.13 12.0 1.6 1.5 1 0 0 1 1 1 0 Renal amino acid transporter DUF1477 PF07346.11 VDK84221.1 - 0.22 11.8 1.9 0.64 10.3 1.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1477) FARP PF01581.16 VDK84226.1 - 0.38 11.4 0.6 0.38 11.4 0.6 3.8 5 0 0 5 5 5 0 FMRFamide related peptide family DUF2045 PF09741.9 VDK84227.1 - 6e-85 284.3 0.1 8.6e-85 283.8 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) rve PF00665.26 VDK84227.1 - 0.011 15.9 0.2 0.22 11.7 0.1 2.4 2 0 0 2 2 2 0 Integrase core domain Bim_N PF06773.11 VDK84227.1 - 0.065 12.9 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Bim protein N-terminus PDZ PF00595.24 VDK84231.1 - 1.3e-32 112.0 0.0 1.3e-11 44.7 0.0 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_6 PF17820.1 VDK84231.1 - 1.1e-20 73.2 0.0 3e-05 23.8 0.0 3.2 3 0 0 3 3 3 3 PDZ domain PDZ_2 PF13180.6 VDK84231.1 - 3.2e-09 37.0 0.0 3.9e-05 23.9 0.0 3.2 3 0 0 3 3 3 2 PDZ domain Pkinase PF00069.25 VDK84235.1 - 1e-61 208.6 0.1 1.7e-61 207.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84235.1 - 1.4e-34 119.5 0.0 2.3e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK84235.1 - 0.0001 22.3 0.1 0.0031 17.5 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 VDK84235.1 - 0.001 18.4 0.0 0.002 17.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 VDK84235.1 - 0.0016 17.5 0.2 0.0032 16.5 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 VDK84235.1 - 0.015 14.9 0.2 0.032 13.8 0.2 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 VDK84235.1 - 0.028 13.8 0.1 0.052 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RNA_Me_trans PF04252.13 VDK84235.1 - 0.12 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase Choline_kinase PF01633.20 VDK84236.1 - 1.5e-50 171.8 4.8 2.4e-50 171.1 1.4 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 VDK84236.1 - 2.2e-07 31.1 0.0 3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ank_2 PF12796.7 VDK84240.1 - 3.1e-08 34.1 4.2 0.012 16.2 0.0 4.4 2 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDK84240.1 - 2.4e-05 24.3 3.6 0.79 10.5 0.0 5.2 5 0 0 5 5 5 2 Ankyrin repeat MCM_lid PF17855.1 VDK84240.1 - 6.5e-05 23.3 0.6 0.019 15.4 0.1 3.0 3 0 0 3 3 3 1 MCM AAA-lid domain Ank_5 PF13857.6 VDK84240.1 - 6.8e-05 23.1 3.3 0.78 10.1 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeats (many copies) BTB PF00651.31 VDK84240.1 - 0.0001 22.5 0.0 0.00044 20.5 0.0 2.1 1 0 0 1 1 1 1 BTB/POZ domain Ank PF00023.30 VDK84240.1 - 0.039 14.4 2.9 0.21 12.1 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeat Tetraspanin PF00335.20 VDK84247.1 - 7.1e-21 75.0 13.6 2.7e-14 53.4 3.7 2.6 1 1 1 2 2 2 2 Tetraspanin family FXa_inhibition PF14670.6 VDK84247.1 - 1.2e-09 38.3 2.2 3e-09 37.0 2.2 1.8 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site FLYWCH PF04500.16 VDK84247.1 - 0.014 15.5 1.6 0.057 13.5 0.3 2.5 2 0 0 2 2 2 0 FLYWCH zinc finger domain HrpB1_HrpK PF09613.10 VDK84247.1 - 0.056 13.1 0.6 0.39 10.4 0.1 2.3 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) Pkinase PF00069.25 VDK84249.1 - 1.1e-45 156.1 0.0 2.3e-45 155.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84249.1 - 1.8e-24 86.5 0.0 3.6e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.18 VDK84249.1 - 4.3e-13 49.1 12.8 9.5e-08 32.0 0.6 2.5 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Kdo PF06293.14 VDK84249.1 - 3.3e-05 23.3 0.0 6.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PMEI PF04043.15 VDK84249.1 - 0.016 15.5 0.9 0.52 10.6 0.0 2.3 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor DUF1609 PF07753.11 VDK84249.1 - 0.043 13.3 0.1 0.088 12.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1609) Flavodoxin_NdrI PF07972.11 VDK84249.1 - 0.13 12.5 0.1 0.49 10.6 0.0 1.9 2 0 0 2 2 2 0 NrdI Flavodoxin like DUF3829 PF12889.7 VDK84249.1 - 0.16 11.4 5.5 0.96 8.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) TPR_2 PF07719.17 VDK84249.1 - 0.16 12.1 2.1 18 5.7 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat AcylCoA_dehyd_C PF12186.8 VDK84249.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.2 3 0 0 3 3 3 0 Acyl-CoA dehydrogenase C terminal CHASE3 PF05227.13 VDK84249.1 - 0.42 10.5 3.7 0.32 10.9 1.1 2.0 2 0 0 2 2 2 0 CHASE3 domain HAD_SAK_2 PF18143.1 VDK84249.1 - 0.61 10.4 3.4 0.37 11.1 1.2 1.7 2 0 0 2 2 2 0 HAD domain in Swiss Army Knife RNA repair proteins DNA_topoisoIV PF00521.20 VDK84249.1 - 7.7 5.3 8.4 1.1e+02 1.5 8.4 2.0 1 1 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A LRR_9 PF14580.6 VDK84252.1 - 1.1e-06 28.3 1.5 0.0093 15.5 0.0 3.3 1 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 VDK84252.1 - 3.3e-06 27.3 13.5 0.12 12.9 0.0 5.4 2 1 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 VDK84252.1 - 0.00026 20.8 0.5 26 5.2 0.0 5.1 4 0 0 4 4 4 0 Leucine Rich repeat Ubiquitin_2 PF14560.6 VDK84252.1 - 0.004 17.6 0.1 0.016 15.6 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain LRR_8 PF13855.6 VDK84252.1 - 0.0099 15.6 13.7 0.14 11.9 0.2 4.3 3 1 2 5 5 5 2 Leucine rich repeat ubiquitin PF00240.23 VDK84252.1 - 0.013 15.3 0.0 0.17 11.6 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin family LRR_1 PF00560.33 VDK84252.1 - 0.067 13.8 9.6 4.6 8.2 0.3 5.5 4 1 0 4 4 4 0 Leucine Rich Repeat PDZ_6 PF17820.1 VDK84260.1 - 5.3e-11 42.2 0.0 1.1e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDK84260.1 - 1.8e-10 41.0 0.0 3.5e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK84260.1 - 1.5e-06 28.4 0.1 6.7e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PPS_PS PF02006.16 VDK84260.1 - 0.072 12.6 0.5 0.13 11.9 0.5 1.3 1 0 0 1 1 1 0 Phosphopantothenate/pantothenate synthetase Tricorn_PDZ PF14685.6 VDK84260.1 - 0.12 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Tricorn protease PDZ domain Hexapep PF00132.24 VDK84262.1 - 2.2e-08 33.5 20.7 0.00046 19.8 1.7 4.5 3 2 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 VDK84262.1 - 0.079 12.7 14.2 0.66 9.8 3.9 3.7 2 2 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Brix PF04427.18 VDK84263.1 - 1e-32 113.8 0.1 1.5e-32 113.3 0.1 1.3 1 0 0 1 1 1 1 Brix domain Homeodomain PF00046.29 VDK84264.1 - 1.4e-19 69.7 4.4 2.7e-19 68.8 4.4 1.5 1 0 0 1 1 1 1 Homeodomain KdgM PF06178.13 VDK84264.1 - 0.025 14.2 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 Oligogalacturonate-specific porin protein (KdgM) Phi-29_GP16_7 PF06720.11 VDK84265.1 - 0.031 14.1 0.4 0.061 13.2 0.4 1.5 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 DUF4578 PF15147.6 VDK84276.1 - 5.7 7.8 11.7 0.55 11.1 2.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) Med18 PF09637.10 VDK84279.1 - 2.7e-27 96.2 0.0 2e-20 73.7 0.0 2.0 1 1 1 2 2 2 2 Med18 protein dsDNA_bind PF01984.20 VDK84280.1 - 7.7e-25 87.3 8.3 1.1e-24 86.9 8.3 1.2 1 0 0 1 1 1 1 Double-stranded DNA-binding domain PCI PF01399.27 VDK84280.1 - 0.0033 17.9 0.5 0.0095 16.4 0.4 1.9 1 1 0 1 1 1 1 PCI domain DUF853 PF05872.12 VDK84280.1 - 0.035 12.7 3.8 0.041 12.5 3.8 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) FeoC PF09012.10 VDK84280.1 - 0.11 12.6 0.2 0.22 11.6 0.2 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator Asp PF00026.23 VDK84281.1 - 7.7e-72 242.4 0.0 8.7e-72 242.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 VDK84281.1 - 1.2e-15 58.2 0.2 1.2e-06 28.8 0.0 2.2 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 VDK84281.1 - 0.00074 19.3 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 VDK84281.1 - 0.13 13.0 0.1 12 6.7 0.0 3.0 3 0 0 3 3 3 0 Aspartyl protease 7tm_1 PF00001.21 VDK84282.1 - 4.7e-14 52.3 19.3 6.4e-14 51.9 19.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF5600 PF18150.1 VDK84283.1 - 1.3e-12 48.2 0.6 1.3e-12 48.2 0.6 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5600) EHD_N PF16880.5 VDK84283.1 - 1.4e-08 34.5 0.3 3.3e-08 33.3 0.3 1.7 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 VDK84283.1 - 1e-07 32.2 6.5 2.1e-07 31.1 0.0 3.7 2 2 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 VDK84283.1 - 7.2e-07 29.3 0.0 2.3e-06 27.7 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Effector_1 PF04518.12 VDK84283.1 - 3.3 6.7 10.4 0.34 10.0 1.5 2.5 2 0 0 2 2 2 0 Effector from type III secretion system ASC PF00858.24 VDK84288.1 - 1.1e-55 189.4 11.4 1.3e-55 189.1 11.4 1.0 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel TROVE PF05731.11 VDK84290.1 - 2.2e-30 106.1 0.2 6.4e-26 91.4 0.0 3.4 2 2 0 2 2 2 2 TROVE domain RuvB_C PF05491.13 VDK84290.1 - 0.12 12.3 0.2 0.36 10.8 0.2 1.8 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain Ank_2 PF12796.7 VDK84293.1 - 1.1e-14 54.8 0.1 2.3e-07 31.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK84293.1 - 7e-14 51.7 0.5 0.0016 18.7 0.0 3.6 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 VDK84293.1 - 3.2e-10 40.3 0.7 6e-05 23.5 0.1 3.6 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK84293.1 - 6.2e-10 38.5 0.2 0.12 13.0 0.0 4.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 VDK84293.1 - 3.9e-06 27.1 0.1 0.2 12.1 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat TspO_MBR PF03073.15 VDK84297.1 - 1.1e-15 57.9 7.5 1.7e-15 57.3 7.5 1.2 1 0 0 1 1 1 1 TspO/MBR family TspO_MBR PF03073.15 VDK84298.1 - 1.8e-05 24.8 1.6 2.5e-05 24.3 1.6 1.2 1 0 0 1 1 1 1 TspO/MBR family TspO_MBR PF03073.15 VDK84299.1 - 5.2e-19 68.6 7.5 7.1e-19 68.2 7.5 1.1 1 0 0 1 1 1 1 TspO/MBR family SMN PF06003.12 VDK84300.1 - 4.6e-29 101.5 13.9 7.7e-15 54.8 7.5 3.0 1 1 1 2 2 2 2 Survival motor neuron protein (SMN) TUDOR PF00567.24 VDK84300.1 - 0.00016 21.6 0.1 0.00034 20.6 0.1 1.5 1 0 0 1 1 1 1 Tudor domain SIN1 PF05422.12 VDK84300.1 - 0.081 13.5 2.8 0.1 13.2 0.1 2.1 2 1 0 2 2 2 0 Stress-activated map kinase interacting protein 1 (SIN1) 4F5 PF04419.14 VDK84301.1 - 4.2e-14 53.1 8.1 4.2e-14 53.1 8.1 2.4 2 1 0 2 2 2 1 4F5 protein family DUF4574 PF15141.6 VDK84301.1 - 1 9.3 7.1 1.4 8.9 7.1 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Peptidase_C1 PF00112.23 VDK84302.1 - 1.1e-34 120.5 0.0 1.8e-34 119.7 0.0 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 VDK84302.1 - 3.6e-06 27.3 0.0 9.4e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) DUF4081 PF13312.6 VDK84302.1 - 0.014 15.6 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4081) Peptidase_C1 PF00112.23 VDK84305.1 - 1.7e-54 185.2 0.0 2.6e-54 184.6 0.0 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 VDK84305.1 - 1.4e-08 35.0 0.6 2.8e-08 34.1 0.6 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Ribosomal_L24e PF01246.20 VDK84307.1 - 3.2e-15 56.1 0.3 3.2e-15 56.1 0.3 2.1 2 1 0 2 2 2 1 Ribosomal protein L24e MAS20 PF02064.15 VDK84307.1 - 4.4 7.4 13.4 2.1 8.5 10.7 1.7 2 0 0 2 2 2 0 MAS20 protein import receptor TMEM214 PF10151.9 VDK84307.1 - 5.9 5.2 12.0 7.8 4.8 12.0 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Motile_Sperm PF00635.26 VDK84308.1 - 4.7e-06 26.4 0.1 8e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 MSP (Major sperm protein) domain FAD_binding_1 PF00667.20 VDK84315.1 - 3.8e-20 72.4 0.0 5.2e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 VDK84315.1 - 1.2e-12 48.4 0.0 2e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 VDK84315.1 - 0.14 12.5 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Flavodoxin_1 PF00258.25 VDK84316.1 - 4.7e-28 98.2 0.0 5.5e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 VDK84316.1 - 0.016 15.5 0.0 0.41 10.9 0.0 2.1 1 1 1 2 2 2 0 Flavodoxin domain Flavodoxin_3 PF12641.7 VDK84316.1 - 0.18 11.5 0.0 0.33 10.6 0.0 1.5 1 1 1 2 2 2 0 Flavodoxin domain Zip PF02535.22 VDK84317.1 - 4e-37 128.2 9.4 2.2e-28 99.4 6.6 2.9 1 1 1 2 2 2 2 ZIP Zinc transporter Peptidase_A8 PF01252.18 VDK84317.1 - 0.093 13.0 1.8 0.39 11.0 1.7 2.0 1 1 0 1 1 1 0 Signal peptidase (SPase) II UAA PF08449.11 VDK84319.1 - 5.6e-81 272.1 19.4 6.2e-81 271.9 19.4 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 VDK84319.1 - 4.4e-05 23.0 10.9 0.0013 18.1 0.7 2.4 2 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 VDK84319.1 - 0.0024 18.0 14.9 0.0024 18.0 14.9 2.6 2 1 0 2 2 2 1 EamA-like transporter family PgpA PF04608.13 VDK84319.1 - 0.0089 16.1 1.4 0.0089 16.1 1.4 2.4 1 1 1 2 2 2 1 Phosphatidylglycerophosphatase A Phage_holin_5_2 PF16079.5 VDK84319.1 - 0.046 14.1 2.5 0.065 13.6 0.5 2.4 2 1 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V TMEM234 PF10639.9 VDK84319.1 - 0.21 11.6 7.2 2.5 8.2 1.4 2.4 2 0 0 2 2 2 0 Putative transmembrane family 234 WD40 PF00400.32 VDK84326.1 - 4.1e-16 59.1 5.7 1.6e-06 28.7 0.0 7.9 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK84326.1 - 1.9e-09 37.7 0.1 0.036 14.3 0.0 5.4 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 VDK84326.1 - 7.7e-08 31.8 7.6 0.0064 15.6 0.2 6.7 4 2 2 7 7 7 2 Coatomer WD associated region Clathrin PF00637.20 VDK84326.1 - 7.3e-05 22.7 1.9 0.046 13.6 0.6 3.5 1 1 2 3 3 3 1 Region in Clathrin and VPS eIF2A PF08662.11 VDK84326.1 - 0.0011 18.9 0.0 0.0092 15.9 0.0 2.6 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A TPR_14 PF13428.6 VDK84326.1 - 1.1 10.3 3.4 20 6.3 0.6 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 VDK84327.1 - 1.1e-41 142.9 0.0 3e-41 141.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84327.1 - 2.4e-39 135.2 0.0 4.8e-39 134.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase zf-C2H2_4 PF13894.6 VDK84327.1 - 0.0024 18.6 16.4 0.16 12.9 0.5 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK84327.1 - 0.0051 17.1 1.8 0.013 15.8 0.3 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK84327.1 - 0.026 14.9 0.6 0.1 13.0 0.6 2.1 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 VDK84327.1 - 0.065 13.7 16.4 0.19 12.3 0.8 4.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type Mob1_phocein PF03637.17 VDK84328.1 - 5.9e-75 250.9 0.1 8.3e-75 250.5 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family Metallophos PF00149.28 VDK84330.1 - 7.4e-35 121.3 0.8 1.4e-34 120.4 0.5 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DUF722 PF05263.11 VDK84330.1 - 0.0037 17.5 0.0 0.0074 16.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF722) STPPase_N PF16891.5 VDK84330.1 - 0.0082 16.6 0.2 0.025 15.0 0.2 1.8 1 1 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain RPW8 PF05659.11 VDK84330.1 - 0.022 14.4 0.6 1.3 8.7 0.2 2.3 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF5378 PF17349.2 VDK84330.1 - 0.24 10.7 0.0 0.34 10.2 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5378) WD40 PF00400.32 VDK84331.1 - 0.0001 23.0 2.7 0.11 13.4 0.4 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF3290 PF11694.8 VDK84331.1 - 0.086 12.8 0.0 0.37 10.8 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) ZU5 PF00791.20 VDK84339.1 - 4e-20 72.0 0.0 7.9e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 ZU5 domain UPA PF17217.3 VDK84339.1 - 2.3e-14 53.5 0.0 4.2e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 UPA domain Death PF00531.22 VDK84339.1 - 3.7e-11 43.0 0.0 6.6e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Death domain TSP_1 PF00090.19 VDK84339.1 - 2e-06 27.9 25.8 4.7e-05 23.5 10.8 3.5 3 0 0 3 3 3 2 Thrombospondin type 1 domain UPF0560 PF10577.9 VDK84339.1 - 0.0041 15.7 1.1 0.0064 15.1 1.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 Thioredoxin_8 PF13905.6 VDK84340.1 - 1.4e-20 73.4 0.1 3e-20 72.4 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 VDK84340.1 - 1.2e-12 47.8 0.0 1.8e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK84340.1 - 2.1e-10 40.5 0.0 3e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin PF00085.20 VDK84340.1 - 5.6e-10 39.1 0.2 7.5e-08 32.3 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 VDK84340.1 - 2.1e-05 24.9 0.0 3.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 VDK84340.1 - 4.4e-05 23.3 0.0 0.00021 21.0 0.0 2.0 1 1 1 2 2 2 1 Thioredoxin SCO1-SenC PF02630.14 VDK84340.1 - 0.0034 17.3 0.0 0.023 14.6 0.0 2.1 1 1 1 2 2 2 1 SCO1/SenC Thioredoxin_7 PF13899.6 VDK84340.1 - 0.012 15.8 0.0 0.04 14.1 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin-like Glutaredoxin PF00462.24 VDK84340.1 - 0.075 13.3 0.1 0.31 11.3 0.0 2.1 2 1 0 2 2 2 0 Glutaredoxin PARG_cat PF05028.14 VDK84342.1 - 1.9e-122 408.8 0.0 4.5e-122 407.6 0.0 1.6 2 0 0 2 2 2 1 Poly (ADP-ribose) glycohydrolase (PARG) E1_dh PF00676.20 VDK84344.1 - 4.1e-70 236.1 0.0 5.7e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 VDK84344.1 - 1.5e-64 217.0 0.0 2.4e-64 216.3 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 VDK84344.1 - 1.4e-50 170.9 0.0 3.3e-50 169.7 0.0 1.7 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 VDK84344.1 - 1.6e-16 59.6 1.1 1.6e-16 59.6 1.1 3.1 3 0 0 3 3 3 1 2-oxoglutarate dehydrogenase N-terminus UQ_con PF00179.26 VDK84345.1 - 2.6e-53 179.4 0.1 3.2e-53 179.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK84345.1 - 0.00096 18.9 0.0 0.0014 18.3 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 VDK84345.1 - 0.0032 17.7 0.1 0.0056 17.0 0.1 1.5 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 VDK84345.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain UFC1 PF08694.11 VDK84345.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Alpha-amylase PF00128.24 VDK84347.1 - 2.6e-33 116.0 1.3 3.4e-33 115.6 1.3 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain SLC3A2_N PF16028.5 VDK84347.1 - 1.3e-21 75.9 1.6 2.1e-21 75.3 1.6 1.3 1 0 0 1 1 1 1 Solute carrier family 3 member 2 N-terminus BatD PF13584.6 VDK84347.1 - 0.079 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance DUF1218 PF06749.12 VDK84347.1 - 0.085 13.4 0.3 0.14 12.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) Mem_trans PF03547.18 VDK84347.1 - 0.14 10.5 1.3 0.21 9.9 1.3 1.2 1 0 0 1 1 1 0 Membrane transport protein 7TM_GPCR_Srw PF10324.9 VDK84350.1 - 0.41 9.9 25.0 9.5 5.4 25.0 2.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Spem1 PF15670.5 VDK84350.1 - 0.91 9.0 6.8 0.37 10.3 2.8 2.0 2 0 0 2 2 2 0 Spermatid maturation protein 1 SH2 PF00017.24 VDK84351.1 - 1e-19 70.4 0.1 4.1e-09 36.4 0.0 2.5 2 0 0 2 2 2 2 SH2 domain PI3K_P85_iSH2 PF16454.5 VDK84351.1 - 3.8e-09 36.3 12.2 6.4e-09 35.6 12.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain PEPcase PF00311.17 VDK84351.1 - 0.029 12.5 6.9 0.038 12.1 6.9 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Terminase_3C PF17288.2 VDK84351.1 - 0.082 13.3 1.3 0.18 12.1 0.7 1.8 1 1 0 1 1 1 0 Terminase RNAseH like domain 5_nucleotid PF05761.14 VDK84353.1 - 2e-166 554.4 0.5 2.4e-166 554.2 0.5 1.0 1 0 0 1 1 1 1 5' nucleotidase family USP8_dimer PF08969.11 VDK84353.1 - 0.053 13.7 0.9 0.053 13.7 0.9 1.8 2 0 0 2 2 2 0 USP8 dimerisation domain MAM PF00629.23 VDK84356.1 - 9.3e-09 35.4 0.9 0.0034 17.3 0.1 3.3 2 2 0 2 2 2 2 MAM domain, meprin/A5/mu PTPLA PF04387.14 VDK84363.1 - 6.6e-36 123.5 6.0 9.6e-36 123.0 6.0 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA MIP PF00230.20 VDK84365.1 - 4.1e-38 131.4 6.1 5.5e-38 130.9 6.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein C6 PF01681.17 VDK84366.1 - 5.1e-05 23.7 0.4 5.8e-05 23.5 0.4 1.2 1 0 0 1 1 1 1 C6 domain DUF2406 PF10295.9 VDK84366.1 - 0.043 14.5 0.0 0.066 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein (DUF2406) Hist_deacetyl PF00850.19 VDK84368.1 - 1.1e-84 284.5 0.7 6.1e-82 275.5 0.0 2.2 2 0 0 2 2 2 2 Histone deacetylase domain BACK PF07707.15 VDK84370.1 - 9.5e-06 25.7 0.0 2.5e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 BTB And C-terminal Kelch Neur_chan_LBD PF02931.23 VDK84375.1 - 2.2e-06 27.3 0.2 8.9e-06 25.3 0.0 1.9 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK84375.1 - 0.0021 18.2 0.8 0.0041 17.2 0.4 1.6 1 1 1 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Dynactin PF12455.8 VDK84376.1 - 4.3e-45 154.2 0.1 4.3e-45 154.2 0.1 4.7 3 2 1 4 4 4 1 Dynein associated protein CAP_GLY PF01302.25 VDK84376.1 - 4.4e-24 84.3 2.6 8e-24 83.4 2.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain MbeD_MobD PF04899.12 VDK84376.1 - 0.013 15.6 2.7 0.013 15.6 2.7 5.1 6 0 0 6 6 6 0 MbeD/MobD like OrfB_IS605 PF01385.19 VDK84377.1 - 0.07 13.4 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 Probable transposase Tex_YqgF PF16921.5 VDK84378.1 - 1.1e-33 116.3 0.1 2.3e-33 115.3 0.1 1.5 1 0 0 1 1 1 1 Tex protein YqgF-like domain Tex_N PF09371.10 VDK84378.1 - 6.8e-26 91.0 0.1 1.7e-25 89.8 0.2 1.6 2 0 0 2 2 2 1 Tex-like protein N-terminal domain HHH_3 PF12836.7 VDK84378.1 - 1.5e-24 86.0 0.0 6.9e-24 83.9 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_7 PF14635.6 VDK84378.1 - 5.5e-10 39.5 0.7 1.8e-09 37.9 0.1 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_9 PF17674.1 VDK84378.1 - 1.2e-08 35.7 0.0 1.2e-08 35.7 0.0 2.8 4 0 0 4 4 2 1 HHH domain S1 PF00575.23 VDK84378.1 - 0.0024 18.1 0.0 0.0048 17.2 0.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain YqgF PF14639.6 VDK84378.1 - 0.0041 16.9 0.0 0.012 15.4 0.0 1.9 1 1 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH PF00633.23 VDK84378.1 - 0.0069 16.2 0.0 0.19 11.7 0.0 2.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 VDK84378.1 - 0.015 15.9 0.5 5.4 7.7 0.0 3.2 3 0 0 3 3 3 0 Helix-hairpin-helix domain HTH_44 PF14641.6 VDK84378.1 - 0.051 14.0 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 TT_ORF2 PF02957.15 VDK84378.1 - 0.061 14.2 0.4 3.1 8.7 0.0 2.3 2 0 0 2 2 2 0 TT viral ORF2 Forkhead PF00250.18 VDK84383.1 - 1.4e-27 95.8 0.5 4.4e-27 94.2 0.5 1.9 1 1 0 1 1 1 1 Forkhead domain DUF3530 PF12048.8 VDK84383.1 - 0.12 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) 7tm_1 PF00001.21 VDK84384.1 - 4.8e-14 52.3 14.1 1.3e-13 50.9 8.3 2.0 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 VDK84384.1 - 3.7e-05 23.2 3.5 3.7e-05 23.2 3.5 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF2530 PF10745.9 VDK84384.1 - 0.52 10.6 3.3 0.29 11.4 0.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2530) bZIP_2 PF07716.15 VDK84385.1 - 2.4e-14 53.1 13.7 3.8e-14 52.5 13.7 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 VDK84385.1 - 9.6e-05 22.4 9.1 0.00021 21.3 9.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor SR-25 PF10500.9 VDK84385.1 - 0.00042 20.0 5.7 0.00069 19.3 5.7 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Cas_Csy4 PF09618.10 VDK84385.1 - 0.014 15.5 2.3 0.023 14.9 2.3 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) bZIP_Maf PF03131.17 VDK84385.1 - 0.21 12.1 10.8 0.068 13.7 7.5 1.8 1 1 1 2 2 2 0 bZIP Maf transcription factor Transket_pyr PF02779.24 VDK84386.1 - 1.3e-40 139.0 0.0 1.8e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 VDK84386.1 - 1.3e-33 115.5 0.0 2.1e-33 114.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain NTP_transf_7 PF07984.12 VDK84388.1 - 2.5e-137 457.4 0.1 3.4e-137 457.0 0.1 1.2 1 0 0 1 1 1 1 Nucleotidyltransferase Homeobox_KN PF05920.11 VDK84392.1 - 0.017 15.0 1.2 0.041 13.8 0.5 2.1 2 0 0 2 2 2 0 Homeobox KN domain Pacs-1 PF10254.9 VDK84394.1 - 6.5e-66 223.0 4.5 2.3e-65 221.2 0.2 3.1 2 1 0 2 2 2 1 PACS-1 cytosolic sorting protein APG9 PF04109.16 VDK84396.1 - 8.3e-132 440.6 2.6 1e-131 440.3 2.6 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 DUF1744 PF08490.12 VDK84402.1 - 6.3e-96 321.4 0.0 9.2e-96 320.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 VDK84402.1 - 3.8e-69 233.4 0.7 7.6e-69 232.4 0.7 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 VDK84402.1 - 9.1e-14 51.0 2.2 3.1e-09 36.1 0.2 3.8 4 1 0 4 4 4 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 VDK84402.1 - 3.7e-07 30.0 0.5 1.6e-06 28.0 0.5 2.0 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 VDK84402.1 - 5.4e-05 23.2 0.0 0.00031 20.8 0.0 2.3 2 0 0 2 2 2 1 RNase_H superfamily zf-RING_2 PF13639.6 VDK84403.1 - 5.2e-13 49.1 9.1 5.2e-13 49.1 9.1 2.1 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 VDK84403.1 - 1.4e-10 41.3 6.6 3.5e-10 40.0 6.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 VDK84403.1 - 2.7e-10 39.9 8.4 2.7e-10 39.9 8.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 VDK84403.1 - 2.7e-08 33.4 5.2 2.7e-08 33.4 5.2 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 VDK84403.1 - 1.3e-07 31.5 13.1 1.5e-07 31.2 7.2 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zinc_ribbon_9 PF14369.6 VDK84403.1 - 2.6e-07 30.8 1.2 2.6e-07 30.8 1.2 2.7 3 0 0 3 3 2 1 zinc-ribbon zf-RING_UBOX PF13445.6 VDK84403.1 - 4.9e-07 29.7 3.8 4.9e-07 29.7 3.8 2.7 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK84403.1 - 1.2e-06 28.3 5.0 1.2e-06 28.3 5.0 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK84403.1 - 1.9e-06 27.6 8.3 1.9e-06 27.6 8.3 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK84403.1 - 3.8e-06 26.8 3.6 9e-06 25.7 3.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 VDK84403.1 - 1e-05 25.3 5.0 1e-05 25.3 5.0 2.1 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 VDK84403.1 - 0.00075 19.1 5.4 0.00075 19.1 5.4 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 VDK84403.1 - 0.0013 18.7 11.9 0.006 16.5 1.5 3.2 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 HypA PF01155.19 VDK84403.1 - 0.003 17.6 3.9 0.14 12.2 0.2 2.3 2 0 0 2 2 2 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 VDK84403.1 - 0.03 14.3 8.9 0.51 10.4 0.2 2.7 2 1 1 3 3 3 0 zinc-ribbons zf-ribbon_3 PF13248.6 VDK84403.1 - 0.08 12.4 4.6 0.16 11.4 0.7 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-Nse PF11789.8 VDK84403.1 - 0.09 12.6 5.4 0.25 11.2 5.4 1.8 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 VDK84403.1 - 0.097 12.6 0.9 0.26 11.2 0.9 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DZR PF12773.7 VDK84403.1 - 0.14 12.2 6.8 4.5 7.4 0.3 2.5 2 0 0 2 2 2 0 Double zinc ribbon FANCL_C PF11793.8 VDK84403.1 - 0.15 12.3 6.2 1.2 9.4 6.2 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain DUF1272 PF06906.11 VDK84403.1 - 0.18 11.9 9.0 1.3 9.1 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) TF_Zn_Ribbon PF08271.12 VDK84403.1 - 0.54 9.8 8.3 0.28 10.7 2.7 3.0 3 1 0 3 3 3 0 TFIIB zinc-binding RINGv PF12906.7 VDK84403.1 - 0.54 10.4 7.9 1.5 9.1 7.9 1.8 1 0 0 1 1 1 0 RING-variant domain zf_UBZ PF18439.1 VDK84403.1 - 0.57 9.8 7.6 8.4 6.1 0.0 4.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger OrfB_Zn_ribbon PF07282.11 VDK84403.1 - 0.76 9.7 11.4 4.9 7.1 0.4 4.2 5 0 0 5 5 4 0 Putative transposase DNA-binding domain PHD PF00628.29 VDK84403.1 - 4.2 7.3 15.2 1.2 9.1 5.6 3.1 2 2 1 3 3 3 0 PHD-finger zf-RING_4 PF14570.6 VDK84403.1 - 4.9 7.0 11.9 0.44 10.4 5.2 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain NOB1_Zn_bind PF08772.11 VDK84404.1 - 4.3e-28 97.3 0.1 9.1e-28 96.2 0.1 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 VDK84404.1 - 6.4e-27 93.9 0.0 1.2e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 PIN domain of ribonuclease UPF0184 PF03670.13 VDK84404.1 - 0.022 15.2 0.8 0.049 14.0 0.8 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) zf-TFIIB PF13453.6 VDK84404.1 - 0.066 12.6 0.3 7.3 6.0 0.1 2.5 2 0 0 2 2 2 0 Transcription factor zinc-finger DZR PF12773.7 VDK84404.1 - 0.088 12.9 0.2 0.19 11.8 0.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon WD40 PF00400.32 VDK84407.1 - 2.4e-34 116.8 15.0 2.8e-05 24.8 0.1 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat PRP4 PF08799.11 VDK84407.1 - 2.6e-11 42.9 1.3 2.6e-11 42.9 1.3 2.3 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 VDK84407.1 - 3.3e-06 27.3 0.1 0.26 11.6 0.0 5.2 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain FANCI_S1-cap PF14674.6 VDK84407.1 - 0.25 11.5 0.5 5.5 7.2 0.1 2.5 2 0 0 2 2 2 0 FANCI solenoid 1 cap Ofd1_CTDD PF10637.9 VDK84415.1 - 3e-13 49.7 0.0 4.9e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 VDK84415.1 - 0.042 14.5 0.0 0.07 13.8 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 VDK84416.1 - 0.0092 16.5 4.3 0.0092 16.5 4.3 2.6 3 0 0 3 3 3 1 ShK domain-like ZYG-11_interact PF05884.12 VDK84418.1 - 1.4e-29 103.5 6.1 1.6e-29 103.2 6.1 1.0 1 0 0 1 1 1 1 Interactor of ZYG-11 Bax1-I PF01027.20 VDK84418.1 - 1.5 8.6 20.1 34 4.2 19.9 2.1 1 1 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Imm5 PF14423.6 VDK84420.1 - 0.13 12.4 0.0 0.47 10.7 0.0 1.9 2 0 0 2 2 2 0 Immunity protein Imm5 Adaptin_binding PF10199.9 VDK84420.1 - 0.9 10.2 4.6 2.2 8.9 4.6 1.6 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 SlyX PF04102.12 VDK84421.1 - 0.056 14.1 0.3 0.063 13.9 0.3 1.3 1 0 0 1 1 1 0 SlyX PfkB PF00294.24 VDK84422.1 - 6.6e-61 206.2 0.0 1.1e-60 205.5 0.0 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 VDK84422.1 - 1.1e-07 31.6 0.0 1.7e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase SAM_1 PF00536.30 VDK84423.1 - 3.5e-05 24.2 0.0 6.4e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK84423.1 - 0.00083 19.4 0.0 0.002 18.2 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HDC PF02329.16 VDK84423.1 - 0.0027 16.8 0.0 0.006 15.6 0.0 1.5 1 0 0 1 1 1 1 Histidine carboxylase PI chain SAM_PNT PF02198.16 VDK84423.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain zf-MYND PF01753.18 VDK84423.1 - 0.46 10.6 2.5 0.6 10.2 0.6 2.2 2 0 0 2 2 2 0 MYND finger Globin PF00042.22 VDK84428.1 - 8.3e-16 58.5 1.2 1.2e-15 58.1 1.2 1.2 1 0 0 1 1 1 1 Globin Xpo1 PF08389.12 VDK84428.1 - 0.065 13.3 0.1 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Exportin 1-like protein Hist_deacetyl PF00850.19 VDK84429.1 - 7e-47 160.4 0.0 8.1e-47 160.2 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain WD40 PF00400.32 VDK84430.1 - 3.7e-17 62.4 0.7 0.00011 22.9 0.0 5.1 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK84430.1 - 0.0076 16.5 0.1 10 6.5 0.0 3.6 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 VDK84430.1 - 0.23 9.7 0.0 0.37 9.1 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Peptidase_M1 PF01433.20 VDK84431.1 - 3.5e-61 206.6 1.2 4.5e-61 206.2 1.2 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 VDK84431.1 - 8.1e-24 84.8 0.0 1.3e-23 84.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF45 PF01863.17 VDK84431.1 - 0.022 14.8 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF45 Peptidase_M78 PF06114.13 VDK84431.1 - 0.038 13.9 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 IrrE N-terminal-like domain FA_desaturase PF00487.24 VDK84431.1 - 0.048 13.5 0.4 0.11 12.4 0.4 1.5 1 0 0 1 1 1 0 Fatty acid desaturase Collagen PF01391.18 VDK84438.1 - 9.5 6.1 23.4 34 4.3 13.7 2.5 1 1 1 2 2 2 0 Collagen triple helix repeat (20 copies) zf-LITAF-like PF10601.9 VDK84439.1 - 4.9e-20 71.6 2.9 8.8e-20 70.8 2.9 1.4 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Tmemb_9 PF05434.11 VDK84439.1 - 0.0048 16.8 0.3 0.0095 15.8 0.0 1.6 1 1 0 1 1 1 1 TMEM9 zf-FPG_IleRS PF06827.14 VDK84439.1 - 0.02 14.8 3.1 0.22 11.4 0.1 2.5 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS GFA PF04828.14 VDK84439.1 - 0.022 15.1 0.9 0.074 13.4 0.1 2.0 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme THF_DHG_CYH_C PF02882.19 VDK84439.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain zf-C4_Topoisom PF01396.19 VDK84439.1 - 0.27 11.1 4.9 5.3 6.9 0.1 2.4 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf_C2H2_10 PF18414.1 VDK84439.1 - 0.87 9.2 7.0 2.4 7.8 0.2 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger RNA_POL_M_15KD PF02150.16 VDK84439.1 - 3.3 7.7 7.6 4.5 7.2 0.3 2.5 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit Cys_rich_KTR PF14205.6 VDK84439.1 - 9.9 6.1 8.9 9.7 6.1 0.3 2.6 3 0 0 3 3 3 0 Cysteine-rich KTR ANAPC1 PF12859.7 VDK84440.1 - 0.058 14.0 2.7 4 8.0 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 1 BSD PF03909.17 VDK84441.1 - 1.5e-21 76.1 2.7 4.9e-16 58.5 0.1 2.6 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 VDK84441.1 - 3.6e-18 65.7 0.0 4.2e-16 59.1 0.0 2.4 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain RolB_RolC PF02027.17 VDK84441.1 - 0.48 10.1 2.6 14 5.3 2.6 3.1 1 1 0 1 1 1 0 RolB/RolC glucosidase family UAE_UbL PF14732.6 VDK84441.1 - 1.3 9.7 6.3 1 10.0 0.6 3.3 3 0 0 3 3 3 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain TetR_C_19 PF17924.1 VDK84441.1 - 1.9 9.1 6.4 1.4 9.5 0.7 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain AIF-MLS PF14962.6 VDK84442.1 - 0.019 14.9 0.2 0.026 14.5 0.1 1.2 1 1 0 1 1 1 0 Mitochondria Localisation Sequence SIT PF15330.6 VDK84442.1 - 0.14 12.6 0.0 0.21 12.1 0.0 1.2 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT LUD_dom PF02589.15 VDK84446.1 - 0.082 12.6 0.1 0.19 11.4 0.0 1.5 1 1 0 2 2 2 0 LUD domain Pkinase PF00069.25 VDK84448.1 - 9e-22 77.7 0.1 1.1e-21 77.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84448.1 - 1.2e-10 41.2 0.0 1.5e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK84448.1 - 0.00075 18.4 0.8 0.0027 16.6 0.1 1.9 2 0 0 2 2 2 1 Fungal protein kinase RRM_1 PF00076.22 VDK84450.1 - 5.6e-26 90.2 0.1 2.5e-16 59.2 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK84450.1 - 0.0034 17.4 0.0 0.087 12.9 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif DbpA PF03880.15 VDK84450.1 - 0.022 14.8 0.8 4.9 7.2 0.0 2.7 3 0 0 3 3 3 0 DbpA RNA binding domain RRM_5 PF13893.6 VDK84450.1 - 0.026 14.1 0.0 0.46 10.1 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK84450.1 - 0.033 14.0 0.0 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 VDK84450.1 - 0.039 13.9 0.0 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif PRP38_assoc PF12871.7 VDK84450.1 - 0.071 13.7 43.3 0.26 11.9 43.3 2.0 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term CDC45 PF02724.14 VDK84450.1 - 0.34 9.2 12.4 0.42 8.8 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Apt1 PF10351.9 VDK84450.1 - 2.1 7.1 18.3 2.7 6.7 18.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_M22 PF00814.25 VDK84452.1 - 9.6e-59 199.3 0.0 1.2e-58 199.0 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family FEZ PF07763.13 VDK84453.1 - 3.8e-79 265.8 5.7 4.7e-79 265.5 5.7 1.1 1 0 0 1 1 1 1 FEZ-like protein ER PF01133.17 VDK84453.1 - 0.026 14.5 0.5 0.2 11.7 0.2 2.3 2 0 0 2 2 2 0 Enhancer of rudimentary FTO_CTD PF12934.7 VDK84453.1 - 5 6.9 8.4 1.1 9.0 1.3 2.6 2 1 1 3 3 3 0 FTO C-terminal domain WD40 PF00400.32 VDK84455.1 - 3.9e-10 40.1 9.4 0.045 14.7 1.2 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Dynein_IC2 PF11540.8 VDK84455.1 - 4.6e-06 26.5 0.6 1.5e-05 24.9 0.6 1.8 1 0 0 1 1 1 1 Cytoplasmic dynein 1 intermediate chain 2 ANAPC4_WD40 PF12894.7 VDK84455.1 - 0.00044 20.5 0.3 0.029 14.6 0.1 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PNP_phzG_C PF10590.9 VDK84464.1 - 5.4e-18 64.8 0.6 9.8e-18 64.0 0.6 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 VDK84464.1 - 7.6e-17 61.3 0.0 1.2e-16 60.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 VDK84464.1 - 1.2e-06 29.1 0.0 2.6e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 VDK84464.1 - 0.068 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like Herpes_UL49_5 PF05702.11 VDK84464.1 - 0.11 12.5 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL49.5 envelope/tegument protein Lectin_C PF00059.21 VDK84465.1 - 2e-31 108.9 10.3 5.6e-11 43.1 0.0 5.4 4 2 0 4 4 4 4 Lectin C-type domain Chordopox_A33R PF05966.12 VDK84465.1 - 0.028 13.7 9.9 0.47 9.7 0.1 3.4 4 0 0 4 4 4 0 Chordopoxvirus A33R protein UL45 PF05473.12 VDK84465.1 - 0.075 12.7 1.2 8.2 6.0 0.0 3.6 3 0 0 3 3 3 0 UL45 protein, carbohydrate-binding C-type lectin-like Leo1 PF04004.13 VDK84465.1 - 0.15 11.9 0.0 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Leo1-like protein Motile_Sperm PF00635.26 VDK84466.1 - 4.5e-25 87.6 0.0 4.9e-25 87.5 0.0 1.0 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Glyco_hydro_30C PF17189.4 VDK84466.1 - 0.026 14.8 0.1 0.035 14.3 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain DUF4381 PF14316.6 VDK84467.1 - 0.11 12.7 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) ETX_MTX2 PF03318.13 VDK84468.1 - 3.2e-05 23.8 0.0 3.2e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 MOZ_SAS PF01853.18 VDK84473.1 - 3.3e-71 238.7 0.0 6.9e-71 237.6 0.0 1.6 1 0 0 1 1 1 1 MOZ/SAS family Pkinase_Tyr PF07714.17 VDK84473.1 - 2.2e-64 217.2 0.0 3.7e-64 216.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK84473.1 - 2.1e-39 135.5 0.0 4.1e-39 134.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain zf-MYST PF17772.1 VDK84473.1 - 8.5e-16 57.3 0.3 2.4e-15 55.8 0.0 2.0 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 VDK84473.1 - 0.0037 17.7 0.0 0.009 16.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RepL PF05732.11 VDK84473.1 - 0.14 11.6 0.1 0.36 10.2 0.0 1.7 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) IF2_N PF04760.15 VDK84473.1 - 0.18 11.7 0.4 0.78 9.6 0.1 2.3 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region MFS_1 PF07690.16 VDK84474.1 - 5.1e-11 42.1 0.5 5.6e-11 42.0 0.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 VDK84474.1 - 0.00016 20.7 2.5 0.00019 20.5 2.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK84477.1 - 4.9e-29 101.4 13.2 4.9e-29 101.4 13.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ion_trans_2 PF07885.16 VDK84478.1 - 3.3e-31 107.1 22.1 1.4e-17 63.5 5.7 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 VDK84478.1 - 5.7e-06 25.7 17.7 0.0045 16.2 3.7 2.3 2 0 0 2 2 2 2 Ion transport protein IRK PF01007.20 VDK84478.1 - 0.00069 19.5 3.3 0.044 13.6 0.3 2.5 2 0 0 2 2 2 2 Inward rectifier potassium channel transmembrane domain UPF0640 PF15114.6 VDK84478.1 - 0.0087 15.8 3.8 0.033 14.0 0.4 2.4 2 0 0 2 2 2 1 Uncharacterised protein family UPF0640 Mononeg_mRNAcap PF14318.6 VDK84478.1 - 0.15 11.3 1.3 0.25 10.5 1.3 1.2 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V Jnk-SapK_ap_N PF09744.9 VDK84487.1 - 3.8e-29 101.9 11.7 3.8e-29 101.9 11.7 3.4 2 1 2 4 4 4 1 JNK_SAPK-associated protein-1 RILP PF11461.8 VDK84487.1 - 1.4e-10 41.2 5.8 7.1e-10 39.0 5.8 2.2 1 0 0 1 1 1 1 Rab interacting lysosomal protein CP12 PF02672.15 VDK84487.1 - 0.027 15.2 4.1 9.3 7.1 0.0 3.4 2 1 1 3 3 3 0 CP12 domain TSC22 PF01166.18 VDK84487.1 - 0.26 11.6 0.1 0.26 11.6 0.1 4.4 3 1 1 4 4 4 0 TSC-22/dip/bun family CDC45 PF02724.14 VDK84488.1 - 0.33 9.2 3.0 0.42 8.8 3.0 1.1 1 0 0 1 1 1 0 CDC45-like protein TLP-20 PF06088.11 VDK84488.1 - 1.5 8.7 4.2 24 4.7 0.0 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) P4Ha_N PF08336.11 VDK84491.1 - 3.6e-35 120.9 0.2 1.5e-34 118.9 0.1 2.0 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 VDK84491.1 - 1.5e-14 54.7 0.0 5.8e-14 52.7 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 VDK84491.1 - 3.3e-07 30.7 0.0 4.6e-05 23.8 0.0 2.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.17 VDK84491.1 - 0.0013 18.7 1.3 0.0064 16.5 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK84491.1 - 0.03 15.0 0.0 0.062 14.0 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK84491.1 - 0.043 14.0 0.3 0.38 11.0 0.4 2.5 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 EMP24_GP25L PF01105.24 VDK84494.1 - 1.1e-43 149.3 0.0 2e-43 148.5 0.0 1.4 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD P4Ha_N PF08336.11 VDK84494.1 - 1.3e-30 106.1 2.8 1.3e-30 106.1 2.8 1.8 2 0 0 2 2 2 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2OG-FeII_Oxy_3 PF13640.6 VDK84494.1 - 1.6e-16 61.0 0.0 5.4e-16 59.3 0.0 2.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 VDK84494.1 - 1.4e-08 35.1 0.0 3.3e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_2 PF07719.17 VDK84494.1 - 5.4e-05 23.0 1.9 0.00042 20.2 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat SPO22 PF08631.10 VDK84494.1 - 0.0037 16.8 0.1 0.014 14.9 0.0 1.9 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like Fis1_TPR_C PF14853.6 VDK84494.1 - 0.012 15.7 0.1 0.024 14.7 0.1 1.6 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 VDK84494.1 - 0.063 13.8 0.1 0.16 12.5 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK84494.1 - 0.16 12.2 0.1 0.58 10.4 0.1 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 VDK84494.1 - 0.25 11.3 1.2 0.51 10.3 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 VDK84496.1 - 2.7e-66 223.5 2.2 1.7e-65 220.9 2.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK84496.1 - 6.1e-33 114.3 1.1 2.8e-29 102.3 0.8 2.1 2 0 0 2 2 2 2 Protein kinase domain SH2 PF00017.24 VDK84496.1 - 2.9e-09 36.9 0.0 6.1e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 SH2 domain zf-C3HC4 PF00097.25 VDK84497.1 - 8.9e-06 25.5 29.2 0.00064 19.5 0.8 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK84497.1 - 2.2e-05 24.7 33.9 0.00029 21.1 18.9 3.3 3 1 0 3 3 3 2 Ring finger domain zf-RING_UBOX PF13445.6 VDK84497.1 - 0.00024 21.1 20.9 0.0087 16.1 13.1 2.9 2 1 0 2 2 2 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDK84497.1 - 0.0003 20.6 27.3 0.026 14.4 17.9 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK84497.1 - 0.00052 19.9 33.3 0.019 14.9 21.2 2.8 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_11 PF17123.5 VDK84497.1 - 0.0018 18.0 4.9 0.0018 18.0 4.9 3.5 2 1 1 3 3 3 1 RING-like zinc finger CBM_17_28 PF03424.14 VDK84497.1 - 0.14 11.9 0.1 0.29 10.8 0.1 1.5 2 0 0 2 2 2 0 Carbohydrate binding domain (family 17/28) zf-RING_6 PF14835.6 VDK84497.1 - 6.3 6.8 14.9 1.6 8.6 8.5 2.5 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Laminin_EGF PF00053.24 VDK84501.1 - 2.5e-93 306.1 251.8 4e-10 39.7 10.1 15.2 13 2 2 15 15 15 14 Laminin EGF domain Laminin_N PF00055.17 VDK84501.1 - 1.8e-79 266.7 3.1 2.1e-79 266.4 0.3 2.8 2 0 0 2 2 2 1 Laminin N-terminal (Domain VI) F5_F8_type_C PF00754.25 VDK84501.1 - 0.011 15.9 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 F5/8 type C domain GARP PF16731.5 VDK84501.1 - 6.9 6.3 49.3 0.019 14.6 14.5 4.7 2 2 3 5 5 5 0 Glutamic acid/alanine-rich protein of Trypanosoma UCH PF00443.29 VDK84503.1 - 9.9e-23 80.9 0.0 3.4e-22 79.2 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK84503.1 - 2e-05 24.4 5.0 2e-05 24.4 5.0 2.7 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ANT PF03374.14 VDK84503.1 - 0.046 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Phage antirepressor protein KilAC domain Beta_helix PF13229.6 VDK84514.1 - 1.3e-57 194.1 39.0 1.2e-27 96.7 5.8 4.1 1 1 3 4 4 4 3 Right handed beta helix region NosD PF05048.13 VDK84514.1 - 1.1e-38 132.9 22.0 4.8e-18 65.3 2.9 3.7 1 1 2 4 4 4 3 Periplasmic copper-binding protein (NosD) zf-UBR PF02207.20 VDK84514.1 - 1.9e-08 34.4 14.8 4.4e-08 33.2 14.8 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Lipocalin_7 PF14651.6 VDK84515.1 - 0.016 15.2 0.1 0.02 14.9 0.1 1.2 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family RHS_repeat PF05593.14 VDK84515.1 - 0.05 14.1 0.0 1.1 9.8 0.0 2.2 2 0 0 2 2 2 0 RHS Repeat Shisa PF13908.6 VDK84516.1 - 0.033 14.4 0.0 0.07 13.4 0.0 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Herpes_gE PF02480.16 VDK84516.1 - 0.074 11.8 0.0 0.098 11.4 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Cullin PF00888.22 VDK84517.1 - 2.7e-149 498.7 10.7 9.8e-122 407.6 5.4 2.1 1 1 1 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 VDK84517.1 - 3.7e-17 62.1 1.9 3.7e-17 62.1 1.9 2.3 3 0 0 3 3 3 1 Cullin protein neddylation domain Stork_head PF10264.9 VDK84517.1 - 0.0087 16.2 0.0 0.029 14.5 0.0 1.9 1 0 0 1 1 1 1 Winged helix Storkhead-box1 domain MOZ_SAS PF01853.18 VDK84519.1 - 2.6e-77 258.5 0.2 4.3e-77 257.8 0.2 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 VDK84519.1 - 1.2e-20 72.8 1.6 3.3e-20 71.4 1.6 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 VDK84519.1 - 0.0037 17.6 0.0 0.0084 16.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RepL PF05732.11 VDK84519.1 - 0.0058 16.1 0.0 0.018 14.4 0.1 1.7 2 0 0 2 2 2 1 Firmicute plasmid replication protein (RepL) SH2 PF00017.24 VDK84520.1 - 5.5e-15 55.2 0.1 1.1e-14 54.3 0.1 1.6 1 0 0 1 1 1 1 SH2 domain GvpL_GvpF PF06386.11 VDK84520.1 - 0.51 10.2 8.2 1.4 8.8 8.2 1.7 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Cwf_Cwc_15 PF04889.12 VDK84520.1 - 4.1 7.1 27.9 5.9 6.6 10.1 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Pro_isomerase PF00160.21 VDK84522.1 - 1.2e-52 178.4 0.0 1.4e-52 178.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ELO PF01151.18 VDK84523.1 - 2.5e-69 233.6 22.9 2.9e-69 233.4 22.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family BBS1 PF14779.6 VDK84525.1 - 7.2e-94 314.0 0.8 2.7e-92 308.8 0.0 2.7 3 0 0 3 3 3 2 Ciliary BBSome complex subunit 1 Fcf2 PF08698.11 VDK84526.1 - 2.6e-35 120.7 0.7 6.1e-35 119.5 0.7 1.7 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing LRR_4 PF12799.7 VDK84527.1 - 2.4e-09 37.3 10.9 0.23 11.9 0.3 6.7 2 1 4 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 VDK84527.1 - 4e-09 36.2 0.7 8e-09 35.3 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 VDK84527.1 - 1.7e-06 27.7 3.6 7e-06 25.8 0.8 2.7 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 VDK84527.1 - 4.1e-06 26.4 4.8 0.067 13.3 0.0 6.5 7 1 0 7 7 7 1 Leucine Rich repeat LRR_1 PF00560.33 VDK84527.1 - 0.0066 16.8 3.0 52 5.0 0.0 6.4 6 2 0 6 6 6 0 Leucine Rich Repeat Preseq_ALAS PF09029.10 VDK84527.1 - 0.045 14.3 4.1 3.7 8.0 0.1 3.9 4 0 0 4 4 4 0 5-aminolevulinate synthase presequence LRR_8 PF13855.6 VDK84527.1 - 0.11 12.2 9.0 12 5.7 0.1 5.1 3 2 1 4 4 4 0 Leucine rich repeat Dynamin_N PF00350.23 VDK84528.1 - 2.6e-40 138.2 0.2 2.6e-40 138.2 0.2 3.1 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 VDK84528.1 - 4.4e-05 23.5 0.0 0.00022 21.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK84528.1 - 6.3e-05 22.6 0.2 0.0039 16.7 0.3 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 VDK84528.1 - 0.0014 18.0 0.3 0.019 14.3 0.3 2.5 2 0 0 2 2 2 1 AIG1 family DUF1593 PF07632.11 VDK84528.1 - 0.012 15.1 0.6 0.039 13.4 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1593) Roc PF08477.13 VDK84528.1 - 0.024 14.9 0.0 0.64 10.2 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 VDK84528.1 - 0.035 14.4 1.7 3.1 8.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 VDK84528.1 - 0.057 13.8 0.7 0.52 10.7 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain OST3_OST6 PF04756.13 VDK84528.1 - 0.18 11.1 1.1 0.32 10.3 1.1 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family ASD1 PF08688.10 VDK84528.1 - 0.32 11.4 6.3 2.3 8.6 6.3 2.3 1 1 0 1 1 1 0 Apx/Shroom domain ASD1 Lactamase_B PF00753.27 VDK84548.1 - 5.2e-14 52.7 0.1 6.4e-14 52.4 0.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 VDK84548.1 - 5.4e-07 29.3 0.0 6.9e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 VDK84548.1 - 0.00053 19.5 0.0 0.00069 19.1 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Antibiotic_NAT PF02522.14 VDK84548.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.1 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase Lactamase_B_3 PF13483.6 VDK84548.1 - 0.055 13.4 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Tmemb_cc2 PF10267.9 VDK84551.1 - 5.3e-93 312.3 15.3 1.1e-92 311.3 15.3 1.4 1 1 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein DUF2935 PF11155.8 VDK84551.1 - 0.0033 17.7 0.0 0.033 14.5 0.0 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF2935) DUF4618 PF15397.6 VDK84551.1 - 0.0039 16.6 17.7 0.12 11.8 1.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4618) V-set_CD47 PF08204.11 VDK84551.1 - 0.0083 16.1 0.6 0.025 14.5 0.2 2.0 2 0 0 2 2 2 1 CD47 immunoglobulin-like domain HAD_2 PF13419.6 VDK84551.1 - 0.051 13.7 4.4 0.12 12.5 0.2 2.7 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase CCDC92 PF14916.6 VDK84551.1 - 0.056 13.2 5.7 1.4 8.7 0.6 2.9 2 0 0 2 2 2 0 Coiled-coil domain of unknown function Exonuc_VII_L PF02601.15 VDK84551.1 - 0.097 12.2 9.7 1.9 8.0 0.3 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Lipoprotein_20 PF13942.6 VDK84551.1 - 0.13 12.2 13.1 0.89 9.4 1.6 2.5 2 0 0 2 2 2 0 YfhG lipoprotein KMP11 PF03037.16 VDK84551.1 - 0.16 12.8 10.4 1.1 10.1 0.9 2.7 3 0 0 3 3 2 0 Kinetoplastid membrane protein 11 SlyX PF04102.12 VDK84551.1 - 0.23 12.1 19.3 0.38 11.4 1.5 4.4 3 1 1 4 4 4 0 SlyX PhoU PF01895.19 VDK84551.1 - 0.26 11.8 7.2 1.2 9.6 0.0 3.5 3 1 0 4 4 3 0 PhoU domain Dna2 PF08696.11 VDK84551.1 - 0.33 10.7 4.4 0.15 11.8 1.0 2.1 2 0 0 2 2 2 0 DNA replication factor Dna2 DUF2937 PF11157.8 VDK84551.1 - 0.4 10.4 2.1 0.42 10.3 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) SpoOE-like PF09388.10 VDK84551.1 - 0.59 10.1 0.1 0.59 10.1 0.1 4.1 5 0 0 5 5 3 0 Spo0E like sporulation regulatory protein MCC-bdg_PDZ PF10506.9 VDK84551.1 - 0.81 9.7 16.3 16 5.6 0.5 4.5 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome ADIP PF11559.8 VDK84551.1 - 0.82 9.8 23.4 0.18 11.9 1.0 3.9 3 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding TMF_TATA_bd PF12325.8 VDK84551.1 - 0.85 9.9 22.6 0.65 10.2 6.9 3.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4140 PF13600.6 VDK84551.1 - 0.89 10.0 6.5 32 5.1 0.1 3.8 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) UPF0242 PF06785.11 VDK84551.1 - 0.92 9.6 17.0 4.3 7.4 8.7 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SKA2 PF16740.5 VDK84551.1 - 0.97 9.2 16.4 0.076 12.8 4.8 3.5 3 1 1 4 4 4 0 Spindle and kinetochore-associated protein 2 Myc-LZ PF02344.15 VDK84551.1 - 0.99 9.6 12.7 1.5 9.0 5.3 2.6 2 0 0 2 2 2 0 Myc leucine zipper domain GTP-bdg_M PF16360.5 VDK84551.1 - 1.4 9.6 7.5 18 6.0 0.0 3.9 4 1 1 5 5 5 0 GTP-binding GTPase Middle Region Cep57_MT_bd PF06657.13 VDK84551.1 - 1.5 9.3 15.5 0.53 10.8 0.4 3.9 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 TMPIT PF07851.13 VDK84551.1 - 1.8 7.7 13.8 5.9 6.0 0.4 2.8 2 1 0 2 2 2 0 TMPIT-like protein DUF2203 PF09969.9 VDK84551.1 - 2.2 9.0 13.7 1.4 9.6 1.0 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Cob_adeno_trans PF01923.18 VDK84551.1 - 3.3 7.8 7.5 5.4 7.1 0.3 3.0 2 2 1 3 3 3 0 Cobalamin adenosyltransferase PIN_8 PF18476.1 VDK84551.1 - 3.6 7.4 14.2 2 8.2 6.9 2.2 2 0 0 2 2 2 0 PIN like domain Csm1_N PF18504.1 VDK84551.1 - 4.1 7.8 21.0 4.5 7.7 0.2 4.7 4 1 1 5 5 5 0 Csm1 N-terminal domain CCDC74_C PF14917.6 VDK84551.1 - 4.6 7.8 9.5 9.3 6.8 3.0 3.2 2 2 1 3 3 3 0 Coiled coil protein 74, C terminal Uds1 PF15456.6 VDK84551.1 - 5 7.3 13.9 0.27 11.4 2.4 2.8 2 1 0 2 2 2 0 Up-regulated During Septation BST2 PF16716.5 VDK84551.1 - 6 7.5 18.5 0.27 11.8 3.4 3.3 3 1 1 4 4 3 0 Bone marrow stromal antigen 2 Baculo_PEP_C PF04513.12 VDK84551.1 - 6.8 6.7 17.4 12 5.9 10.0 3.0 2 2 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YlqD PF11068.8 VDK84551.1 - 7.1 7.0 21.1 0.18 12.2 3.4 2.9 2 1 1 3 3 3 0 YlqD protein DUF2802 PF10975.8 VDK84551.1 - 8.1 6.6 9.8 23 5.2 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2802) Arrestin_N PF00339.29 VDK84552.1 - 4.4e-17 62.5 0.0 3.2e-14 53.2 0.0 2.8 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 VDK84552.1 - 6.3e-13 49.3 0.0 3e-12 47.1 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 VDK84552.1 - 0.0015 17.8 0.0 0.004 16.4 0.0 1.6 1 1 0 2 2 2 1 Rgp1 Spo0M PF07070.11 VDK84552.1 - 0.039 13.5 0.0 0.16 11.5 0.0 2.0 3 0 0 3 3 3 0 SpoOM protein RRM_1 PF00076.22 VDK84554.1 - 7.6e-17 60.9 0.0 1.1e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Adaptin_N PF01602.20 VDK84565.1 - 4.8e-137 457.7 4.0 6.2e-137 457.3 4.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region AP3D1 PF06375.11 VDK84565.1 - 3.4e-32 111.9 3.6 3.4e-32 111.9 3.6 3.2 2 1 1 3 3 3 1 AP-3 complex subunit delta-1 Cnd1 PF12717.7 VDK84565.1 - 3.5e-15 56.4 0.1 1.5e-11 44.6 0.0 2.8 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 VDK84565.1 - 2.6e-06 27.2 1.4 0.87 10.0 0.0 5.1 4 0 0 4 4 4 2 HEAT repeat RTP1_C1 PF10363.9 VDK84565.1 - 1.3e-05 25.4 0.9 0.22 11.7 0.0 3.5 3 0 0 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 VDK84565.1 - 2.1e-05 24.8 0.1 0.14 12.6 0.0 3.6 3 1 2 5 5 5 3 HEAT repeats RasGEF_N_2 PF14663.6 VDK84565.1 - 0.011 16.1 0.0 1 9.8 0.0 3.1 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Vac14_Fab1_bd PF12755.7 VDK84565.1 - 0.056 14.0 0.4 0.69 10.6 0.1 3.0 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region SHQ1 PF04925.15 VDK84566.1 - 2.1e-52 177.2 0.8 3e-52 176.7 0.8 1.2 1 0 0 1 1 1 1 SHQ1 protein adh_short PF00106.25 VDK84567.1 - 8e-05 22.2 1.2 0.00018 21.0 1.2 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK84567.1 - 0.00056 19.5 0.2 0.00069 19.2 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 VDK84567.1 - 0.0045 16.5 0.1 0.013 15.0 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ribosomal_S5 PF00333.20 VDK84567.1 - 0.037 14.0 0.1 0.078 13.0 0.1 1.5 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain FF PF01846.19 VDK84568.1 - 1.3e-67 223.8 40.1 2.8e-14 53.0 3.1 6.6 6 0 0 6 6 6 6 FF domain WW PF00397.26 VDK84568.1 - 2.4e-26 91.5 25.7 9.1e-10 38.5 5.0 3.9 3 0 0 3 3 3 3 WW domain Glyco_hyd_101C PF17451.2 VDK84568.1 - 0.0023 18.2 5.4 1.2 9.5 0.0 3.7 3 0 0 3 3 3 2 Glycosyl hydrolase 101 beta sandwich domain Rer1 PF03248.13 VDK84568.1 - 0.3 10.8 2.0 22 4.7 0.6 2.9 2 0 0 2 2 2 0 Rer1 family DUF1794 PF08768.11 VDK84576.1 - 2.3e-16 60.1 0.0 2.8e-16 59.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) Adaptin_N PF01602.20 VDK84579.1 - 5.9e-150 500.3 6.0 7.7e-150 499.9 6.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 VDK84579.1 - 6e-41 139.2 0.1 2.4e-40 137.3 0.0 2.1 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 VDK84579.1 - 1e-12 48.3 0.1 2.1e-12 47.3 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 VDK84579.1 - 7.9e-09 35.8 0.1 4.1e-07 30.2 0.0 3.0 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 VDK84579.1 - 0.00014 22.2 1.3 0.23 11.9 0.1 4.0 3 0 0 3 3 3 1 HEAT repeats B2-adapt-app_C PF09066.10 VDK84579.1 - 0.0012 18.9 0.4 0.025 14.6 0.0 2.6 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 VDK84579.1 - 0.0076 16.4 2.0 43 4.7 0.0 5.3 5 0 0 5 5 5 0 HEAT repeat PI3_PI4_kinase PF00454.27 VDK84581.1 - 1.1e-12 48.4 0.0 1.5e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Adeno_PIX PF03955.14 VDK84581.1 - 0.064 13.4 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Rootletin PF15035.6 VDK84582.1 - 1.2e-35 123.2 53.6 4e-35 121.5 24.7 14.6 6 3 7 13 13 13 4 Ciliary rootlet component, centrosome cohesion TPR_MLP1_2 PF07926.12 VDK84582.1 - 0.00018 21.6 17.4 0.00018 21.6 17.4 19.7 9 5 7 18 18 18 8 TPR/MLP1/MLP2-like protein ADIP PF11559.8 VDK84582.1 - 0.0043 17.2 19.4 0.0043 17.2 19.4 20.6 6 3 13 21 21 21 9 Afadin- and alpha -actinin-Binding SlyX PF04102.12 VDK84582.1 - 0.014 16.0 2.3 0.014 16.0 2.3 27.4 12 7 17 30 30 30 0 SlyX Vps39_1 PF10366.9 VDK84589.1 - 3.6e-29 101.2 5.6 1.4e-28 99.3 0.5 2.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 VDK84589.1 - 5.9e-18 65.5 0.0 1.8e-17 63.9 0.0 1.8 1 0 0 1 1 1 1 CNH domain Vps39_2 PF10367.9 VDK84589.1 - 3.6e-13 49.9 1.6 2.5e-09 37.5 0.2 3.1 3 0 0 3 3 3 2 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 VDK84589.1 - 1.4e-10 41.2 7.0 1.6e-06 28.1 0.3 3.1 2 1 0 2 2 2 2 Region in Clathrin and VPS D123 PF07065.14 VDK84589.1 - 0.012 14.7 0.2 1.8 7.6 0.2 2.3 2 0 0 2 2 2 0 D123 TPR_12 PF13424.6 VDK84589.1 - 0.99 9.7 4.4 0.68 10.3 0.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TBCA PF02970.16 VDK84590.1 - 4e-25 88.0 3.6 6.3e-25 87.3 3.6 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor A Val_tRNA-synt_C PF10458.9 VDK84590.1 - 0.043 14.1 1.4 0.12 12.7 1.0 1.9 1 1 1 2 2 2 0 Valyl tRNA synthetase tRNA binding arm FliG_N PF14842.6 VDK84590.1 - 0.057 14.0 0.2 0.14 12.7 0.1 1.6 1 1 1 2 2 2 0 FliG N-terminal domain Prion PF00377.18 VDK84590.1 - 0.11 12.3 0.8 0.54 10.1 0.8 2.0 1 1 0 1 1 1 0 Prion/Doppel alpha-helical domain Med2 PF11214.8 VDK84590.1 - 0.24 11.6 3.1 0.45 10.7 0.3 2.1 1 1 1 2 2 2 0 Mediator complex subunit 2 CENP-F_leu_zip PF10473.9 VDK84590.1 - 0.34 10.9 8.1 2.3 8.2 8.2 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Ran_BP1 PF00638.18 VDK84592.1 - 1.7e-72 241.4 7.8 5.5e-37 126.8 1.5 2.7 2 0 0 2 2 2 2 RanBP1 domain zf-RanBP PF00641.18 VDK84592.1 - 0.00012 21.3 5.3 0.00024 20.4 5.3 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others WH1 PF00568.23 VDK84592.1 - 0.0021 18.0 0.3 0.54 10.2 0.0 2.9 2 0 0 2 2 2 2 WH1 domain SLC12 PF03522.15 VDK84593.1 - 1.3e-11 44.2 2.5 7e-05 22.0 3.1 3.0 2 1 0 2 2 2 2 Solute carrier family 12 Peptidase_C1 PF00112.23 VDK84599.1 - 2.8e-47 161.6 8.1 4.1e-47 161.1 8.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 VDK84599.1 - 0.14 10.9 2.6 5.8 5.6 0.6 2.1 2 0 0 2 2 2 0 Peptidase C1-like family Na_H_Exchanger PF00999.21 VDK84601.1 - 2e-72 244.1 36.8 2.3e-72 243.9 36.8 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Beta-lactamase PF00144.24 VDK84602.1 - 1e-48 166.3 0.0 1.5e-48 165.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Thioredoxin_7 PF13899.6 VDK84603.1 - 7.3e-19 67.7 0.1 1.5e-18 66.8 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 VDK84603.1 - 1.6e-12 47.0 0.4 2.1e-11 43.5 0.1 2.7 3 0 0 3 3 3 1 UBA-like domain UBX PF00789.20 VDK84603.1 - 1.9e-06 28.0 0.0 3.7e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 UBX domain Thioredoxin_2 PF13098.6 VDK84603.1 - 0.033 14.6 0.0 0.072 13.5 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Pkinase PF00069.25 VDK84604.1 - 1.9e-20 73.3 0.0 4.1e-20 72.3 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84604.1 - 1.2e-11 44.5 0.0 2e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK84604.1 - 0.017 13.9 0.0 0.031 13.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Cadherin PF00028.17 VDK84606.1 - 4.7e-45 151.9 0.0 4.5e-11 43.0 0.0 8.2 8 0 0 8 8 8 6 Cadherin domain Cadherin PF00028.17 VDK84608.1 - 6e-06 26.6 0.1 0.00065 20.1 0.0 2.5 2 0 0 2 2 2 2 Cadherin domain Comm PF15957.5 VDK84608.1 - 0.1 12.9 0.2 0.33 11.3 0.2 1.9 1 0 0 1 1 1 0 Commissureless TMEM135_C_rich PF15982.5 VDK84609.1 - 6e-26 91.6 1.6 7.2e-26 91.4 0.7 1.6 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 DSPc PF00782.20 VDK84614.1 - 7.9e-28 96.9 0.2 1.4e-27 96.1 0.2 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK84614.1 - 3.2e-05 23.6 0.0 4.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 VDK84614.1 - 0.0048 17.2 0.1 0.011 16.1 0.1 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 VDK84614.1 - 0.079 12.9 0.0 0.099 12.6 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Peptidase_M23 PF01551.22 VDK84615.1 - 8.2e-10 38.8 0.0 6.4e-07 29.5 0.0 2.3 2 0 0 2 2 2 2 Peptidase family M23 NUDIX PF00293.28 VDK84616.1 - 4.3e-14 52.7 0.0 6.1e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Tax PF02959.16 VDK84616.1 - 0.015 14.8 0.2 0.15 11.5 0.1 2.1 1 1 1 2 2 2 0 HTLV Tax HOOK PF05622.12 VDK84617.1 - 8.1e-89 298.6 76.6 1e-88 298.3 76.6 1.0 1 0 0 1 1 1 1 HOOK protein TPR_MLP1_2 PF07926.12 VDK84617.1 - 0.0067 16.5 12.4 0.0067 16.5 12.4 7.1 4 1 2 7 7 7 3 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 VDK84617.1 - 1.9 8.5 98.2 0.066 13.2 14.0 6.5 1 1 5 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PHD PF00628.29 VDK84619.1 - 0.00032 20.5 8.4 0.0008 19.3 8.4 1.7 1 0 0 1 1 1 1 PHD-finger Integrase_1 PF12835.7 VDK84619.1 - 0.11 12.6 0.1 0.21 11.7 0.1 1.3 1 0 0 1 1 1 0 Integrase C1_1 PF00130.22 VDK84619.1 - 1.2 9.0 4.4 0.53 10.2 1.0 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_2 PF13639.6 VDK84619.1 - 2.6 8.5 9.0 20 5.6 9.0 2.4 1 1 0 1 1 1 0 Ring finger domain DERM PF14704.6 VDK84627.1 - 0.00075 20.0 1.2 0.0013 19.2 1.2 1.4 1 0 0 1 1 1 1 Dermatopontin CCDC73 PF15818.5 VDK84627.1 - 0.068 11.0 0.1 0.08 10.8 0.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 73 family Kelch_1 PF01344.25 VDK84628.1 - 2.9e-60 199.6 12.9 3.2e-12 45.8 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 VDK84628.1 - 1.7e-25 88.4 7.6 1.7e-05 24.9 0.1 6.7 3 2 3 6 6 6 5 Kelch motif Kelch_4 PF13418.6 VDK84628.1 - 6.6e-21 74.1 1.4 0.0011 18.9 0.1 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain BTB PF00651.31 VDK84628.1 - 1.2e-15 57.7 0.7 1.7e-14 54.0 0.7 2.3 1 1 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 VDK84628.1 - 1.9e-15 56.7 1.6 0.078 13.3 0.0 6.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 VDK84628.1 - 7.5e-14 51.1 8.6 0.00012 21.9 0.0 6.6 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 VDK84628.1 - 1.4e-07 31.3 6.4 0.016 15.2 0.0 4.5 4 0 0 4 4 4 2 Kelch motif BACK PF07707.15 VDK84628.1 - 0.0063 16.6 0.1 0.013 15.6 0.1 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch Arch_fla_DE PF04659.13 VDK84628.1 - 0.12 12.3 0.2 0.3 11.0 0.2 1.6 1 0 0 1 1 1 0 Archaeal flagella protein Galactosyl_T PF01762.21 VDK84630.1 - 2e-34 119.1 1.0 2.6e-34 118.8 1.0 1.1 1 0 0 1 1 1 1 Galactosyltransferase Fringe PF02434.16 VDK84630.1 - 0.00027 20.5 0.1 0.00041 19.9 0.1 1.4 1 1 0 1 1 1 1 Fringe-like THAP PF05485.12 VDK84630.1 - 0.05 14.5 0.1 0.43 11.5 0.1 2.1 2 0 0 2 2 2 0 THAP domain KOG2701 PF09762.9 VDK84631.1 - 0.011 15.9 1.7 0.032 14.5 1.7 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) DUF1664 PF07889.12 VDK84631.1 - 0.093 12.8 6.6 0.28 11.2 0.7 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) YkuI_C PF10388.9 VDK84631.1 - 0.19 11.5 1.7 0.44 10.3 1.7 1.5 1 0 0 1 1 1 0 EAL-domain associated signalling protein domain Thioredoxin PF00085.20 VDK84632.1 - 1.6e-59 198.2 0.0 2.4e-28 98.1 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 VDK84632.1 - 4.2e-08 32.9 0.0 0.0053 16.2 0.0 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_6 PF13848.6 VDK84632.1 - 2.8e-07 30.6 0.0 7.4e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_2 PF13098.6 VDK84632.1 - 8.4e-07 29.4 2.8 0.022 15.2 0.3 4.3 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK84632.1 - 1.4e-05 25.4 0.2 0.2 12.0 0.0 4.1 3 2 1 5 5 5 2 Thioredoxin-like Thioredoxin_7 PF13899.6 VDK84632.1 - 0.0001 22.4 0.1 0.56 10.4 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like Thioredoxin_9 PF14595.6 VDK84632.1 - 0.0011 18.7 0.0 0.26 11.1 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.6 VDK84632.1 - 0.0024 17.9 0.0 1.3 9.1 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin domain TraF PF13728.6 VDK84632.1 - 0.0067 16.3 0.0 2.5 7.9 0.0 2.5 2 0 0 2 2 2 2 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 VDK84632.1 - 0.014 15.6 0.2 9 6.4 0.0 2.8 2 1 1 3 3 3 0 Thioredoxin Thioredoxin_5 PF13743.6 VDK84632.1 - 0.039 13.6 0.0 16 5.1 0.0 3.0 2 1 1 3 3 3 0 Thioredoxin AhpC-TSA PF00578.21 VDK84632.1 - 0.047 13.6 0.1 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 AhpC/TSA family HlyC PF02794.16 VDK84632.1 - 0.066 13.1 0.0 3.1 7.7 0.0 2.3 2 0 0 2 2 2 0 RTX toxin acyltransferase family DDE_Tnp_1_2 PF13586.6 VDK84632.1 - 0.1 13.0 0.0 25 5.3 0.0 2.3 2 0 0 2 2 2 0 Transposase DDE domain DDE_Tnp_IS1595 PF12762.7 VDK84633.1 - 1.5e-25 90.0 0.0 2.1e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain DIM1 PF02966.16 VDK84634.1 - 3.4e-62 208.1 0.2 1.1e-61 206.4 0.1 1.8 2 0 0 2 2 2 1 Mitosis protein DIM1 Med21 PF11221.8 VDK84634.1 - 1.8e-15 57.5 5.0 2.4e-13 50.6 5.0 2.2 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Thioredoxin PF00085.20 VDK84634.1 - 5.2e-06 26.4 0.0 1.3e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 VDK84634.1 - 0.0048 17.2 0.2 0.014 15.7 0.1 1.8 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.6 VDK84634.1 - 0.039 14.1 0.0 0.093 12.9 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like Thioredox_DsbH PF03190.15 VDK84634.1 - 0.16 11.9 0.1 0.31 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF255 bZIP_1 PF00170.21 VDK84646.1 - 2.5e-07 30.7 4.2 5.6e-07 29.6 4.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 VDK84646.1 - 5.2e-06 26.4 5.0 5.2e-06 26.4 5.0 2.0 2 0 0 2 2 2 1 Basic region leucine zipper TPR_MLP1_2 PF07926.12 VDK84646.1 - 0.017 15.2 2.3 0.034 14.2 2.3 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 VDK84646.1 - 0.017 15.4 1.4 0.034 14.4 1.4 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 SOGA PF11365.8 VDK84646.1 - 0.019 16.1 1.9 0.028 15.5 0.2 2.2 2 1 0 2 2 2 0 Protein SOGA DUF1330 PF07045.11 VDK84646.1 - 0.03 14.7 0.0 0.055 13.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) UPF0242 PF06785.11 VDK84646.1 - 0.034 14.3 3.1 0.054 13.6 3.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus EB PF01683.18 VDK84647.1 - 1.7e-10 41.0 15.0 0.00023 21.4 0.1 3.8 1 1 3 4 4 4 4 EB module Dickkopf_N PF04706.12 VDK84647.1 - 2.3e-06 28.0 32.9 0.15 12.6 0.2 5.1 5 0 0 5 5 5 5 Dickkopf N-terminal cysteine-rich region Connexin PF00029.19 VDK84647.1 - 1.7 8.3 9.9 0.045 13.5 3.4 1.7 2 0 0 2 2 2 0 Connexin DX PF01666.17 VDK84647.1 - 3 8.4 18.9 3.1 8.3 0.3 4.0 2 1 2 4 4 4 0 DX module Collagen PF01391.18 VDK84648.1 - 3.6e-22 77.9 104.4 0.00017 21.3 13.0 4.5 2 1 1 3 3 3 1 Collagen triple helix repeat (20 copies) MCM6_C PF18263.1 VDK84649.1 - 0.0039 17.4 0.1 0.0052 17.0 0.1 1.2 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain H-kinase_dim PF02895.14 VDK84649.1 - 0.06 13.7 0.1 0.11 13.0 0.1 1.4 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain TrbC_Ftype PF09673.10 VDK84649.1 - 0.073 13.1 0.0 0.098 12.7 0.0 1.3 1 1 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein NfI_DNAbd_pre-N PF10524.9 VDK84650.1 - 2.7e-21 75.1 0.5 4.9e-21 74.3 0.5 1.4 1 0 0 1 1 1 1 Nuclear factor I protein pre-N-terminus MH1 PF03165.16 VDK84650.1 - 1.8e-11 44.1 0.3 4e-11 43.1 0.3 1.6 1 0 0 1 1 1 1 MH1 domain malic PF00390.19 VDK84651.1 - 3.3e-75 251.9 0.0 5.1e-75 251.3 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Malic_M PF03949.15 VDK84651.1 - 1.1e-58 198.6 0.0 1.4e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain Lipocalin_2 PF08212.12 VDK84653.1 - 0.00079 19.4 0.0 0.0032 17.4 0.0 1.9 1 1 0 1 1 1 1 Lipocalin-like domain Lipocalin_2 PF08212.12 VDK84654.1 - 0.0055 16.6 0.0 0.049 13.6 0.0 2.1 1 1 0 1 1 1 1 Lipocalin-like domain RabGAP-TBC PF00566.18 VDK84655.1 - 9.9e-32 110.3 4.2 1.6e-31 109.7 4.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 VDK84655.1 - 2.8e-11 43.9 0.0 4.9e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 VDK84656.1 - 2.6e-16 59.8 0.0 5.4e-16 58.8 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84656.1 - 1.8e-11 43.8 0.0 2.6e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PWWP PF00855.17 VDK84661.1 - 8.1e-07 29.4 0.0 2.2e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 PWWP domain DUF1759 PF03564.15 VDK84662.1 - 4.6e-12 46.1 0.0 2.6e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Ras PF00071.22 VDK84672.1 - 2.1e-39 134.7 0.1 2.5e-39 134.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK84672.1 - 2.9e-27 95.3 0.1 4.3e-27 94.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK84672.1 - 9.9e-14 51.2 0.1 1.3e-13 50.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK84672.1 - 2e-06 27.5 0.1 0.00031 20.4 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 VDK84672.1 - 1e-05 25.5 0.1 0.00054 19.8 0.0 2.0 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 VDK84672.1 - 7.4e-05 22.2 0.0 9.1e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDK84672.1 - 0.00023 21.2 0.0 0.00044 20.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDK84672.1 - 0.0014 18.6 0.0 0.57 10.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_5 PF07728.14 VDK84672.1 - 0.0018 18.3 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 VDK84672.1 - 0.0019 17.7 0.0 0.0033 17.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region TniB PF05621.11 VDK84672.1 - 0.0027 17.1 0.0 0.0062 16.0 0.0 1.7 1 0 0 1 1 1 1 Bacterial TniB protein AAA_22 PF13401.6 VDK84672.1 - 0.0049 17.1 0.0 0.011 16.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 VDK84672.1 - 0.016 15.0 0.0 0.15 11.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 VDK84672.1 - 0.025 14.9 0.0 0.075 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 VDK84672.1 - 0.027 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MCM PF00493.23 VDK84672.1 - 0.048 12.8 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_29 PF13555.6 VDK84672.1 - 0.061 13.1 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 VDK84672.1 - 0.071 12.9 0.1 0.18 11.6 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 VDK84672.1 - 0.072 12.2 0.0 0.13 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IIGP PF05049.13 VDK84672.1 - 0.073 12.1 0.0 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) eRF1_2 PF03464.15 VDK84672.1 - 0.11 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 eRF1 domain 2 Sua5_yciO_yrdC PF01300.18 VDK84673.1 - 4.7e-35 120.7 0.0 5.6e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Telomere recombination Ribosomal_L24e PF01246.20 VDK84675.1 - 1e-32 112.1 7.1 1.9e-32 111.3 7.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L24e DUF2175 PF09943.9 VDK84675.1 - 3.6 7.9 8.2 0.68 10.3 4.0 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) SH3_1 PF00018.28 VDK84676.1 - 4.3e-15 55.0 0.1 6.1e-15 54.6 0.1 1.2 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK84676.1 - 3.6e-12 45.9 0.1 5.1e-12 45.5 0.1 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK84676.1 - 6.1e-10 38.6 0.0 9.2e-10 38.1 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain DUF707 PF05212.12 VDK84676.1 - 0.00033 20.0 0.0 0.0004 19.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF707) Pkinase_Tyr PF07714.17 VDK84677.1 - 2.4e-93 312.1 0.0 3.1e-93 311.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK84677.1 - 1.8e-47 161.9 0.0 2.6e-47 161.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK84677.1 - 9.3e-25 86.5 0.2 1.7e-24 85.7 0.2 1.5 1 0 0 1 1 1 1 SH2 domain Haspin_kinase PF12330.8 VDK84677.1 - 3.1e-05 23.1 0.0 9.5e-05 21.5 0.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 VDK84677.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like SRP19 PF01922.17 VDK84679.1 - 4e-27 95.0 0.0 5e-27 94.7 0.0 1.1 1 0 0 1 1 1 1 SRP19 protein DEAD PF00270.29 VDK84680.1 - 2.6e-50 170.6 0.9 1.2e-49 168.4 0.0 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK84680.1 - 4e-23 81.9 0.1 4.5e-22 78.5 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 VDK84680.1 - 2.1e-16 59.9 5.3 2.1e-16 59.9 5.3 2.4 2 0 0 2 2 2 1 DBP10CT (NUC160) domain DNA_pol3_chi PF04364.13 VDK84680.1 - 0.11 12.6 1.3 0.36 11.0 0.2 2.4 2 0 0 2 2 2 0 DNA polymerase III chi subunit, HolC Pox_A32 PF04665.12 VDK84680.1 - 0.69 9.3 3.9 0.59 9.5 0.6 2.4 3 0 0 3 3 3 0 Poxvirus A32 protein TPR_MLP1_2 PF07926.12 VDK84681.1 - 0.19 11.8 49.6 0.062 13.4 11.1 3.2 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Plasmid_parti PF01672.16 VDK84681.1 - 0.41 11.3 6.2 1.9 9.2 0.3 3.0 2 0 0 2 2 2 0 Putative plasmid partition protein MCPsignal PF00015.21 VDK84681.1 - 0.65 9.8 14.3 0.059 13.2 2.1 2.6 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DivIC PF04977.15 VDK84681.1 - 1.4 8.7 35.5 0.18 11.6 6.5 4.4 3 2 1 4 4 4 0 Septum formation initiator KASH_CCD PF14662.6 VDK84681.1 - 2 8.2 41.4 1.2 8.9 11.4 3.1 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH AAA_13 PF13166.6 VDK84681.1 - 2.6 6.6 30.3 1.8 7.1 29.0 1.3 2 0 0 2 2 2 0 AAA domain Spc7 PF08317.11 VDK84681.1 - 2.8 6.8 42.7 0.018 13.9 20.7 2.6 1 1 2 3 3 3 0 Spc7 kinetochore protein REC1 PF18501.1 VDK84681.1 - 2.8 7.8 25.6 4.1 7.2 12.7 2.2 1 1 1 2 2 2 0 Alpha helical recognition lobe domain YabA PF06156.13 VDK84681.1 - 2.9 8.6 32.6 0.1 13.2 4.8 4.0 1 1 2 3 3 3 0 Initiation control protein YabA Folliculin PF11704.8 VDK84681.1 - 3.5 7.5 17.5 2.4 8.0 4.4 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Fib_alpha PF08702.10 VDK84681.1 - 4.1 7.6 28.9 2.3 8.4 4.1 3.3 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family UPF0184 PF03670.13 VDK84681.1 - 6.2 7.3 15.7 9.8 6.6 5.7 3.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) DUF4400 PF14348.6 VDK84681.1 - 6.3 6.2 6.0 3.5 7.1 0.3 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4400) DUF948 PF06103.11 VDK84681.1 - 9.7 6.5 11.5 3.9 7.8 1.1 3.0 2 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Methyltransf_31 PF13847.6 VDK84684.1 - 5.5e-07 29.5 0.0 1.2e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK84684.1 - 3e-05 24.6 0.0 0.0001 22.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 VDK84684.1 - 0.00019 21.0 0.0 0.0004 20.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 VDK84684.1 - 0.0018 17.7 0.0 0.0042 16.6 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase RRM_1 PF00076.22 VDK84684.1 - 0.016 15.0 0.0 0.038 13.8 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PrmA PF06325.13 VDK84684.1 - 0.022 14.1 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 VDK84684.1 - 0.03 13.7 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 VDK84684.1 - 0.084 12.9 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Sec16_N PF12935.7 VDK84684.1 - 0.12 12.5 2.5 0.41 10.8 0.5 2.1 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 N-terminus Methyltransf_23 PF13489.6 VDK84684.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ADAM_CR_2 PF17771.1 VDK84686.1 - 8.6e-15 55.0 1.4 1.8e-14 54.0 1.4 1.5 1 0 0 1 1 1 1 ADAM cysteine-rich domain Reprolysin_5 PF13688.6 VDK84686.1 - 8.9e-09 35.8 2.4 9.8e-08 32.4 2.4 2.0 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin PF01421.19 VDK84686.1 - 1.3e-08 35.0 1.8 1.4e-08 34.9 0.2 1.9 2 1 1 3 3 3 1 Reprolysin (M12B) family zinc metalloprotease Reprolysin_3 PF13582.6 VDK84686.1 - 4e-07 30.6 0.0 6.3e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 VDK84686.1 - 3.8e-05 23.4 0.3 5.3e-05 23.0 0.3 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 VDK84686.1 - 6.6e-05 22.9 0.1 9.8e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Astacin PF01400.24 VDK84686.1 - 0.082 12.5 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) WD40 PF00400.32 VDK84687.1 - 1.6e-06 28.7 14.8 8.9e-05 23.2 0.1 5.7 7 0 0 7 7 7 2 WD domain, G-beta repeat DUF2415 PF10313.9 VDK84687.1 - 0.0012 18.7 0.1 0.011 15.7 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) ANAPC4_WD40 PF12894.7 VDK84687.1 - 0.011 16.1 0.0 0.24 11.7 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain YhhN PF07947.14 VDK84689.1 - 1.4e-12 47.6 19.1 1.9e-12 47.2 19.1 1.1 1 0 0 1 1 1 1 YhhN family Alg14 PF08660.11 VDK84692.1 - 1.5e-57 194.4 0.1 1.9e-57 194.0 0.1 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_transf_28 PF03033.20 VDK84692.1 - 0.003 17.6 0.0 0.0043 17.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain zf-C2H2_2 PF12756.7 VDK84693.1 - 2.7e-11 43.7 0.3 4.3e-11 43.0 0.3 1.4 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) YyzF PF14116.6 VDK84693.1 - 0.012 15.6 2.2 24 5.1 0.1 3.4 3 0 0 3 3 3 0 YyzF-like protein zf-HC5HC2H PF13771.6 VDK84693.1 - 0.03 14.6 0.1 3 8.2 0.0 2.3 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-BED PF02892.15 VDK84693.1 - 0.049 13.7 0.4 3.9 7.6 0.0 2.5 2 0 0 2 2 2 0 BED zinc finger SOR_SNZ PF01680.17 VDK84693.1 - 0.11 12.2 0.1 0.7 9.6 0.0 1.9 2 0 0 2 2 2 0 SOR/SNZ family Glyco_transf_24 PF18404.1 VDK84697.1 - 1e-142 474.3 3.4 1.7e-142 473.6 3.4 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_15 PF18403.1 VDK84697.1 - 3.1e-46 158.0 0.6 2.2e-45 155.2 0.2 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 VDK84697.1 - 2.3e-39 133.9 0.0 1e-38 131.8 0.0 2.1 2 0 0 2 2 2 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 VDK84697.1 - 5.3e-08 32.7 0.4 1e-07 31.8 0.4 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 Ribosomal_L23 PF00276.20 VDK84699.1 - 8.8e-11 42.0 0.6 1.3e-10 41.5 0.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 BBS1 PF14779.6 VDK84699.1 - 0.2 11.1 0.4 0.3 10.5 0.4 1.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 Herpes_UL52 PF03121.15 VDK84704.1 - 1.3e-09 37.8 3.0 1.3e-09 37.8 3.0 1.8 2 0 0 2 2 2 1 Herpesviridae UL52/UL70 DNA primase PPL4 PF18188.1 VDK84704.1 - 0.032 14.2 0.1 0.082 12.8 0.1 1.7 1 0 0 1 1 1 0 Prim-pol 4 PALP PF00291.25 VDK84705.1 - 6e-125 416.5 0.0 5.6e-64 216.4 0.0 2.0 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme DUF374 PF04028.13 VDK84705.1 - 0.00018 21.0 0.1 0.073 12.6 0.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF374) YccV-like PF08755.11 VDK84705.1 - 0.11 13.1 0.0 4.8 7.8 0.0 3.1 3 0 0 3 3 3 0 Hemimethylated DNA-binding protein YccV like MtN3_slv PF03083.16 VDK84706.1 - 7.1e-11 42.0 17.6 4.9e-06 26.5 5.0 2.8 2 1 1 3 3 3 2 Sugar efflux transporter for intercellular exchange PRIMA1 PF16101.5 VDK84706.1 - 0.14 12.2 3.8 0.69 10.0 0.3 3.1 4 0 0 4 4 4 0 Proline-rich membrane anchor 1 Neurensin PF14927.6 VDK84706.1 - 0.65 9.7 4.3 7.9 6.2 0.9 2.8 2 1 1 3 3 3 0 Neurensin Syndecan PF01034.20 VDK84706.1 - 2.3 8.2 6.3 16 5.5 0.1 3.5 3 0 0 3 3 3 0 Syndecan domain Peptidase_C2 PF00648.21 VDK84709.1 - 3.3e-103 344.8 1.2 5.3e-102 340.8 1.2 2.1 1 1 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 VDK84709.1 - 1.2e-22 80.7 0.1 3.7e-22 79.1 0.0 1.9 2 0 0 2 2 2 1 Calpain large subunit, domain III TSP_1 PF00090.19 VDK84711.1 - 1e-11 44.8 5.8 2.4e-11 43.6 5.8 1.7 1 0 0 1 1 1 1 Thrombospondin type 1 domain INTS2 PF14750.6 VDK84712.1 - 1.4e-252 840.7 32.8 5.9e-243 808.8 27.7 2.0 1 1 1 2 2 2 2 Integrator complex subunit 2 SAE2 PF08573.10 VDK84713.1 - 5.1e-07 30.8 7.3 0.00014 23.0 0.1 3.3 3 1 1 4 4 4 2 DNA repair protein endonuclease SAE2/CtIP C-terminus Prefoldin_2 PF01920.20 VDK84714.1 - 1.2e-22 79.9 14.2 1.4e-22 79.6 14.2 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF1192 PF06698.11 VDK84714.1 - 0.0073 16.3 0.5 0.019 15.0 0.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) Osmo_CC PF08946.10 VDK84714.1 - 0.0074 16.5 1.6 0.0074 16.5 1.6 1.8 2 0 0 2 2 2 1 Osmosensory transporter coiled coil ERp29 PF07749.12 VDK84714.1 - 0.025 15.5 6.7 0.051 14.5 1.0 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Prefoldin_3 PF13758.6 VDK84714.1 - 0.028 14.5 5.3 0.077 13.1 5.2 1.8 1 1 0 1 1 1 0 Prefoldin subunit Snf7 PF03357.21 VDK84714.1 - 0.25 10.9 13.5 0.03 13.9 5.8 2.0 2 0 0 2 2 2 0 Snf7 PHM7_cyt PF14703.6 VDK84714.1 - 0.36 11.0 6.3 0.69 10.1 6.3 1.4 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter FlxA PF14282.6 VDK84714.1 - 9 6.4 13.9 0.49 10.4 5.8 2.0 2 0 0 2 2 2 0 FlxA-like protein Piezo_RRas_bdg PF12166.8 VDK84717.1 - 1.4e-18 67.4 0.5 1.5e-18 67.3 0.5 1.0 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain DUF1664 PF07889.12 VDK84718.1 - 0.0029 17.6 0.5 0.0029 17.6 0.5 5.3 4 1 2 6 6 6 2 Protein of unknown function (DUF1664) DUF3563 PF12086.8 VDK84718.1 - 0.0072 16.0 0.8 0.13 12.0 0.1 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF3563) APG6_N PF17675.1 VDK84718.1 - 0.0085 16.6 5.4 0.0085 16.6 5.4 5.1 2 1 2 4 4 4 1 Apg6 coiled-coil region DASH_Dad1 PF08649.10 VDK84718.1 - 0.056 13.6 4.4 5.6 7.2 0.2 3.5 2 0 0 2 2 2 0 DASH complex subunit Dad1 Thioredoxin PF00085.20 VDK84718.1 - 0.058 13.4 2.2 0.12 12.4 0.4 2.5 2 1 0 2 2 2 0 Thioredoxin PI_PP_I PF18363.1 VDK84718.1 - 0.14 12.3 0.2 0.14 12.3 0.2 3.6 3 1 1 4 4 4 0 Phosphoinositide phosphatase insertion domain HJURP_C PF12347.8 VDK84718.1 - 0.23 11.5 5.7 8.2 6.6 0.2 3.3 4 0 0 4 4 4 0 Holliday junction regulator protein family C-terminal repeat DUF99 PF01949.16 VDK84718.1 - 2.7 7.4 5.8 2.1 7.7 0.4 3.2 4 0 0 4 4 4 0 Protein of unknown function DUF99 DUF948 PF06103.11 VDK84718.1 - 5.1 7.4 12.4 3 8.2 0.2 4.2 4 2 0 4 4 4 0 Bacterial protein of unknown function (DUF948) PH PF00169.29 VDK84719.1 - 0.031 14.8 0.7 0.062 13.8 0.7 1.5 1 0 0 1 1 1 0 PH domain DRY_EERY PF09750.9 VDK84719.1 - 1.6 9.0 7.1 22 5.3 7.0 2.2 1 1 1 2 2 2 0 Alternative splicing regulator adh_short PF00106.25 VDK84720.1 - 3.4e-40 137.6 0.1 4.8e-40 137.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK84720.1 - 1.1e-17 64.4 0.0 1.7e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK84720.1 - 2.4e-06 27.6 0.1 6.9e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 VDK84720.1 - 0.00084 18.9 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 VDK84720.1 - 0.00087 19.6 0.2 0.0051 17.1 0.1 2.0 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 VDK84720.1 - 0.016 14.6 0.6 0.3 10.4 0.6 2.1 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Exog_C PF18026.1 VDK84720.1 - 0.096 12.8 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 Endo/exonuclease (EXOG) C-terminal domain Pkinase PF00069.25 VDK84723.1 - 2.1e-71 240.4 0.0 7.6e-71 238.6 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84723.1 - 2.6e-41 141.6 0.1 7.7e-41 140.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Rad4 PF03835.15 VDK84723.1 - 2.1e-23 82.7 4.1 2.1e-23 82.7 4.1 2.6 3 0 0 3 3 3 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 VDK84723.1 - 3.1e-20 72.3 0.0 7.8e-20 71.1 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 VDK84723.1 - 5.2e-15 55.0 0.7 2.3e-14 52.9 0.3 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 VDK84723.1 - 3.5e-08 34.3 0.3 3.5e-08 34.3 0.3 2.3 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 2 Kinase-like PF14531.6 VDK84723.1 - 0.0002 20.8 0.0 0.00038 19.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like YdaS_antitoxin PF15943.5 VDK84723.1 - 0.41 10.5 1.8 2.1 8.3 0.5 2.5 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Urm1 PF09138.11 VDK84724.1 - 5e-29 100.5 0.0 5.6e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 VDK84724.1 - 1.1e-05 26.0 0.0 2.8e-05 24.7 0.0 1.7 1 1 0 1 1 1 1 ThiS family RRM_1 PF00076.22 VDK84725.1 - 1.7e-38 130.3 0.1 7.4e-14 51.3 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK84725.1 - 0.0078 16.1 0.0 5.2 7.0 0.0 3.0 2 0 0 2 2 2 2 Occluded RNA-recognition motif Phage_TAC_13 PF16459.5 VDK84725.1 - 0.013 15.9 0.1 0.44 11.0 0.0 2.9 3 0 0 3 3 3 0 Phage tail assembly chaperone, TAC tRNA-synt_1c PF00749.21 VDK84726.1 - 1.4e-20 73.4 0.0 1.9e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain HEAT_2 PF13646.6 VDK84727.1 - 1.3e-05 25.5 0.0 0.0015 18.9 0.0 3.0 1 1 1 2 2 2 2 HEAT repeats RPN13_C PF16550.5 VDK84727.1 - 0.019 15.2 0.1 0.16 12.2 0.0 2.2 2 0 0 2 2 2 0 UCH-binding domain ELO PF01151.18 VDK84728.1 - 1.3e-15 57.6 7.9 1.5e-15 57.4 7.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family WTF PF03303.13 VDK84728.1 - 0.046 13.5 0.8 0.053 13.2 0.8 1.2 1 0 0 1 1 1 0 WTF protein Lactamase_B PF00753.27 VDK84747.1 - 2.3e-07 31.0 0.2 5e-07 29.9 0.2 1.5 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily ERCC4 PF02732.15 VDK84748.1 - 2.8e-17 63.4 0.0 9.7e-17 61.6 0.0 2.0 1 0 0 1 1 1 1 ERCC4 domain NAGLU_C PF12972.7 VDK84749.1 - 0.013 15.1 0.0 0.029 13.9 0.0 1.5 2 0 0 2 2 2 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NRDE-2 PF08424.10 VDK84751.1 - 1.5e-47 162.3 1.8 6e-42 143.9 0.1 2.7 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference DUF846 PF05832.12 VDK84751.1 - 3.2e-46 156.8 13.7 6.1e-46 155.9 13.7 1.5 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Actin PF00022.19 VDK84753.1 - 3.9e-28 98.2 0.0 1.2e-27 96.5 0.0 1.9 1 0 0 1 1 1 1 Actin Y_phosphatase PF00102.27 VDK84765.1 - 3.4e-62 210.1 5.0 3.4e-62 210.1 5.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK84765.1 - 5.1e-06 26.3 0.0 1.8e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Macoilin PF09726.9 VDK84765.1 - 0.69 8.4 9.5 0.99 7.9 9.5 1.1 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 VDK84765.1 - 6.3 6.1 10.5 12 5.2 10.5 1.4 1 0 0 1 1 1 0 FAM76 protein Zip PF02535.22 VDK84765.1 - 7.1 5.7 7.5 11 5.1 7.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Ank_2 PF12796.7 VDK84768.1 - 1.1e-32 112.5 4.6 3.5e-16 59.6 0.7 5.3 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK84768.1 - 7.9e-27 93.0 7.4 2e-07 31.2 0.3 6.6 4 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK84768.1 - 5.4e-26 87.8 8.6 8e-05 22.8 0.0 8.4 8 0 0 8 8 8 6 Ankyrin repeat Ank_4 PF13637.6 VDK84768.1 - 4.1e-23 81.4 5.4 2.7e-08 34.2 0.1 5.6 3 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 VDK84768.1 - 9.2e-18 63.8 12.6 2.9e-05 24.3 0.2 7.6 7 1 0 7 7 7 5 Ankyrin repeat SAM_1 PF00536.30 VDK84768.1 - 7e-08 32.8 0.0 1.7e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK84768.1 - 7.5e-08 32.4 0.1 3.7e-07 30.2 0.1 2.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Sigma70_ner PF04546.13 VDK84768.1 - 0.39 10.6 4.3 0.68 9.8 4.3 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region NOA36 PF06524.12 VDK84768.1 - 0.56 9.5 6.7 0.89 8.8 6.7 1.3 1 0 0 1 1 1 0 NOA36 protein BUD22 PF09073.10 VDK84768.1 - 6.9 5.9 11.3 1.2 8.4 7.6 1.5 2 0 0 2 2 2 0 BUD22 Ground-like PF04155.18 VDK84770.1 - 2.7e-14 53.6 0.0 7.3e-14 52.2 0.0 1.8 1 0 0 1 1 1 1 Ground-like domain TFIIA PF03153.13 VDK84770.1 - 0.35 10.8 17.3 0.48 10.4 17.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Dynein_light PF01221.18 VDK84770.1 - 1.5 9.2 0.0 1.5 9.2 0.0 2.4 3 0 0 3 3 3 0 Dynein light chain type 1 Spt20 PF12090.8 VDK84770.1 - 1.8 8.1 20.8 3.3 7.3 20.8 1.4 1 0 0 1 1 1 0 Spt20 family DUF2981 PF11200.8 VDK84770.1 - 4.2 7.0 7.1 5.5 6.6 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Presenilin PF01080.17 VDK84770.1 - 4.9 5.8 7.9 5.6 5.6 7.9 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 VDK84770.1 - 5.7 5.5 6.1 6.6 5.3 6.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Coilin_N PF15862.5 VDK84770.1 - 8.4 6.2 10.5 17 5.2 10.5 1.6 1 0 0 1 1 1 0 Coilin N-terminus EIF_2_alpha PF07541.12 VDK84771.1 - 4.2e-34 117.1 0.2 3.5e-33 114.1 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 VDK84771.1 - 1.2e-13 51.2 0.6 2.5e-13 50.1 0.6 1.5 1 0 0 1 1 1 1 S1 RNA binding domain DUF4388 PF14332.6 VDK84771.1 - 0.078 13.3 0.0 0.18 12.1 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4388) Band_7 PF01145.25 VDK84772.1 - 4.8e-21 75.6 1.1 4.8e-21 75.6 1.1 1.9 1 1 1 2 2 2 1 SPFH domain / Band 7 family Peptidase_S66 PF02016.15 VDK84772.1 - 0.15 12.2 0.2 0.47 10.6 0.1 1.9 1 1 1 2 2 2 0 LD-carboxypeptidase N-terminal domain TMEM51 PF15345.6 VDK84779.1 - 0.015 15.2 0.5 0.031 14.1 0.4 1.4 1 1 0 1 1 1 0 Transmembrane protein 51 Cadherin_C_2 PF16492.5 VDK84779.1 - 0.056 14.2 0.6 0.46 11.3 0.1 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Sec61_beta PF03911.16 VDK84779.1 - 0.11 12.5 2.0 0.22 11.6 2.0 1.4 1 0 0 1 1 1 0 Sec61beta family SKG6 PF08693.10 VDK84779.1 - 0.35 10.3 3.5 0.88 9.0 3.5 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RabGAP-TBC PF00566.18 VDK84781.1 - 1.4e-39 136.0 0.8 1.5e-38 132.7 0.8 2.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain C2 PF00168.30 VDK84784.1 - 1.5e-09 38.1 0.0 4.5e-09 36.5 0.0 1.8 1 1 0 1 1 1 1 C2 domain SMP_C2CD2L PF18696.1 VDK84784.1 - 0.00043 20.1 0.0 0.00086 19.2 0.0 1.4 1 0 0 1 1 1 1 Synaptotagmin-like, mitochondrial and lipid-binding domain Pkinase PF00069.25 VDK84793.1 - 5.6e-141 468.5 0.0 2.7e-70 236.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84793.1 - 3.1e-76 256.1 0.0 2.4e-38 131.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 VDK84793.1 - 2e-14 53.6 0.0 4.4e-07 29.5 0.0 2.5 2 1 0 2 2 2 2 Kinase-like Kdo PF06293.14 VDK84793.1 - 1.1e-09 37.9 0.0 6.4e-05 22.4 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 VDK84793.1 - 2.5e-07 29.8 0.0 0.012 14.4 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase APH PF01636.23 VDK84793.1 - 5e-07 29.9 0.1 0.0007 19.6 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 VDK84793.1 - 2.9e-05 23.2 0.1 0.025 13.5 0.0 2.2 2 0 0 2 2 2 2 Haspin like kinase domain Pkinase_C PF00433.24 VDK84793.1 - 5.7e-05 23.7 0.2 0.00017 22.2 0.2 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain YrbL-PhoP_reg PF10707.9 VDK84793.1 - 0.0022 17.6 0.0 0.0098 15.4 0.0 2.1 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 VDK84793.1 - 0.012 15.2 0.1 0.54 9.8 0.0 2.7 2 1 0 3 3 3 0 Choline/ethanolamine kinase RIO1 PF01163.22 VDK84793.1 - 0.021 14.4 0.7 0.056 13.0 0.0 2.0 3 0 0 3 3 3 0 RIO1 family FTA2 PF13095.6 VDK84793.1 - 0.052 13.2 0.1 27 4.3 0.0 3.1 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 PALP PF00291.25 VDK84795.1 - 1.3e-61 208.6 0.0 5.2e-61 206.6 0.0 1.7 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CTP-dep_RFKase PF01982.16 VDK84795.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF120 Laminin_EGF PF00053.24 VDK84796.1 - 8.2e-112 365.2 388.5 6.2e-11 42.3 12.5 20.0 19 1 1 20 20 20 19 Laminin EGF domain Laminin_G_2 PF02210.24 VDK84796.1 - 1e-80 268.5 2.4 5.1e-20 72.3 0.0 5.6 5 0 0 5 5 5 5 Laminin G domain Laminin_N PF00055.17 VDK84796.1 - 2e-71 240.3 0.0 1.6e-70 237.4 0.0 2.8 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) Laminin_G_1 PF00054.23 VDK84796.1 - 4.1e-70 234.1 0.1 1.5e-20 73.7 0.0 5.6 5 0 0 5 5 5 5 Laminin G domain Laminin_B PF00052.18 VDK84796.1 - 2e-55 186.4 0.1 1.4e-28 99.5 0.0 2.6 2 0 0 2 2 2 2 Laminin B (Domain IV) Laminin_II PF06009.12 VDK84796.1 - 6.2e-11 42.5 6.2 6.2e-11 42.5 6.2 3.2 4 0 0 4 4 4 1 Laminin Domain II Gas_vesicle_C PF01304.17 VDK84796.1 - 0.14 12.2 0.0 0.41 10.7 0.0 1.8 1 0 0 1 1 1 0 Gas vesicles protein GVPc repeated domain ANAPC15 PF15243.6 VDK84796.1 - 2.8 8.4 6.0 8.1 6.9 6.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 BLOC1_2 PF10046.9 VDK84796.1 - 5.8 7.3 9.2 4 7.8 0.9 3.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-RING_5 PF14634.6 VDK84804.1 - 0.046 13.7 0.1 0.046 13.7 0.1 2.3 2 0 0 2 2 2 0 zinc-RING finger domain Aa_trans PF01490.18 VDK84805.1 - 1.9e-61 208.0 23.1 1.9e-61 208.0 23.1 1.8 1 1 1 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 VDK84805.1 - 1.6e-08 34.0 20.3 1.6e-08 34.0 20.3 1.9 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family DUF1761 PF08570.10 VDK84805.1 - 0.0071 16.6 0.0 0.0071 16.6 0.0 3.8 4 2 0 4 4 4 1 Protein of unknown function (DUF1761) Rootletin PF15035.6 VDK84806.1 - 0.022 14.8 1.3 0.022 14.8 1.3 2.4 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.21 VDK84806.1 - 0.024 14.7 9.5 0.086 12.9 1.6 3.1 3 0 0 3 3 3 0 bZIP transcription factor CLZ PF16526.5 VDK84806.1 - 0.05 14.0 8.6 0.41 11.0 1.4 3.0 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Uds1 PF15456.6 VDK84806.1 - 0.32 11.2 9.2 1.5 9.0 1.3 3.4 4 0 0 4 4 4 0 Up-regulated During Septation DUF4140 PF13600.6 VDK84806.1 - 1.2 9.6 9.6 1.5 9.3 0.8 3.0 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF4094 PF13334.6 VDK84806.1 - 1.3 9.5 6.5 8.5 6.9 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) Fib_alpha PF08702.10 VDK84806.1 - 2.2 8.5 6.4 1.5 9.0 1.5 2.4 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family UPF0449 PF15136.6 VDK84807.1 - 3.1 8.3 13.2 0.89 10.1 0.7 2.7 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 Phage_Gp23 PF10669.9 VDK84807.1 - 6.9 7.0 8.0 1.5 9.2 4.5 1.7 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) zf-RING_2 PF13639.6 VDK84808.1 - 9.4e-12 45.1 9.7 2.1e-11 44.0 9.7 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 VDK84808.1 - 8.7e-09 35.5 10.0 2.7e-08 34.0 10.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 VDK84808.1 - 1.1e-07 31.6 9.9 2.5e-07 30.4 9.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK84808.1 - 7.7e-06 25.9 2.8 1.5e-05 25.0 2.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 VDK84808.1 - 1.5e-05 24.6 4.1 4.7e-05 23.0 4.1 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 VDK84808.1 - 7.6e-05 22.5 8.1 0.00013 21.8 8.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK84808.1 - 0.0002 21.3 8.1 0.00052 19.9 8.0 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 VDK84808.1 - 0.00069 19.4 9.2 0.0015 18.4 9.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK84808.1 - 0.001 19.0 8.9 0.0031 17.5 8.9 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 VDK84808.1 - 0.0038 17.0 7.3 0.0078 16.1 7.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 DUF1664 PF07889.12 VDK84808.1 - 0.014 15.5 0.6 0.014 15.5 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Spore_II_R PF09551.10 VDK84808.1 - 0.015 15.8 6.6 0.5 10.8 0.2 2.6 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) Zn_ribbon_17 PF17120.5 VDK84808.1 - 0.032 13.8 7.7 0.064 12.9 7.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 VDK84808.1 - 0.15 12.3 8.8 0.41 10.9 8.8 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 VDK84808.1 - 0.41 10.5 5.1 0.91 9.4 5.1 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FANCL_C PF11793.8 VDK84808.1 - 0.42 10.8 7.1 1.9 8.7 7.1 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Snf7 PF03357.21 VDK84809.1 - 8.1e-26 90.7 8.3 1.2e-25 90.0 8.3 1.3 1 0 0 1 1 1 1 Snf7 PspA_IM30 PF04012.12 VDK84809.1 - 0.00035 20.2 13.6 0.0006 19.5 13.6 1.3 1 0 0 1 1 1 1 PspA/IM30 family DUF4032 PF13224.6 VDK84809.1 - 0.0035 17.2 1.6 0.0084 16.0 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4032) DUF5082 PF16888.5 VDK84809.1 - 0.067 13.5 4.0 0.96 9.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF5596 PF18082.1 VDK84809.1 - 0.072 12.9 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5596) GrpE PF01025.19 VDK84809.1 - 0.12 12.0 5.0 0.23 11.1 5.0 1.5 1 0 0 1 1 1 0 GrpE DUF1192 PF06698.11 VDK84809.1 - 0.19 11.8 2.9 0.24 11.5 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) RecX PF02631.16 VDK84809.1 - 0.98 9.9 9.5 5 7.6 0.0 2.6 1 1 1 2 2 2 0 RecX family FapA PF03961.13 VDK84809.1 - 4.2 5.9 8.4 6.1 5.3 7.6 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A I-set PF07679.16 VDK84821.1 - 1.6e-73 242.8 0.0 1.3e-22 79.7 0.0 4.1 4 0 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK84821.1 - 1e-63 211.9 0.0 3.3e-15 56.4 0.0 4.1 4 0 0 4 4 4 4 Immunoglobulin domain ig PF00047.25 VDK84821.1 - 6.3e-44 148.1 0.0 9.5e-13 48.1 0.0 4.4 4 0 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 VDK84821.1 - 2.6e-42 143.1 0.0 1.8e-11 44.2 0.0 4.2 4 0 0 4 4 4 4 Immunoglobulin domain V-set PF07686.17 VDK84821.1 - 6.4e-32 110.0 0.2 4.5e-06 26.8 0.0 7.5 4 4 1 5 5 5 5 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK84821.1 - 6.9e-14 51.7 0.0 0.04 14.0 0.0 4.3 4 0 0 4 4 4 4 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 VDK84821.1 - 4.2e-12 45.4 0.0 0.017 14.7 0.0 4.3 4 0 0 4 4 4 4 Immunoglobulin domain Izumo-Ig PF16706.5 VDK84821.1 - 6e-06 26.2 0.0 1.8 8.7 0.0 4.4 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 VDK84821.1 - 1.2e-05 25.2 0.0 7.2 6.7 0.0 4.6 5 0 0 5 5 5 2 C17orf99 Ig domain zf-RRN7 PF11781.8 VDK84821.1 - 0.00046 19.8 1.8 25 4.6 0.0 4.7 5 0 0 5 5 5 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 C1-set PF07654.15 VDK84821.1 - 0.0071 16.7 0.0 0.28 11.6 0.0 3.2 3 0 0 3 3 3 1 Immunoglobulin C1-set domain V-set_CD47 PF08204.11 VDK84821.1 - 0.031 14.3 0.0 26 4.8 0.0 3.7 4 1 0 4 4 4 0 CD47 immunoglobulin-like domain BiPBP_C PF06832.12 VDK84821.1 - 0.066 13.3 0.0 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family XRN1_DBM PF18245.1 VDK84821.1 - 0.2 11.6 1.7 0.66 10.0 0.5 2.3 2 0 0 2 2 2 0 5-3 exonuclease XRN1 DCP1-binding motif Nop14 PF04147.12 VDK84824.1 - 7.7 4.6 7.9 7.7 4.6 7.9 1.0 1 0 0 1 1 1 0 Nop14-like family fn3 PF00041.21 VDK84826.1 - 1.4e-34 118.3 3.6 3.1e-12 46.7 0.0 4.0 4 0 0 4 4 4 3 Fibronectin type III domain I-set PF07679.16 VDK84826.1 - 2.3e-17 62.8 0.0 5.9e-17 61.5 0.0 1.7 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK84826.1 - 3e-16 59.8 0.0 7.2e-15 55.4 0.0 3.0 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 VDK84826.1 - 2.3e-13 50.1 0.1 5.6e-13 48.9 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 VDK84826.1 - 1.5e-07 31.6 0.0 4.9e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 VDK84826.1 - 4.1e-07 30.2 0.1 1.1e-05 25.5 0.1 2.7 1 1 0 1 1 1 1 Immunoglobulin V-set domain Herpes_gE PF02480.16 VDK84826.1 - 0.001 17.9 0.0 0.0022 16.8 0.0 1.5 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Pur_ac_phosph_N PF16656.5 VDK84826.1 - 0.0088 16.6 4.3 14 6.3 0.0 4.4 5 1 0 5 5 4 2 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 VDK84826.1 - 0.017 15.2 0.0 0.052 13.6 0.0 1.9 1 0 0 1 1 1 0 CD80-like C2-set immunoglobulin domain Ig_6 PF18452.1 VDK84826.1 - 0.018 14.6 0.0 0.04 13.5 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain Ig_4 PF16680.5 VDK84826.1 - 0.18 12.1 0.0 0.51 10.6 0.0 1.8 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain AbrB PF05145.12 VDK84828.1 - 0.0027 16.7 0.2 0.0035 16.3 0.2 1.2 1 0 0 1 1 1 1 Transition state regulatory protein AbrB Ninjurin PF04923.12 VDK84828.1 - 0.0049 16.8 1.4 0.011 15.7 0.5 1.8 2 0 0 2 2 2 1 Ninjurin FA_desaturase PF00487.24 VDK84828.1 - 4.5 7.0 9.2 4.1 7.2 8.3 1.4 1 1 0 1 1 1 0 Fatty acid desaturase GRIP PF01465.20 VDK84830.1 - 2.8e-08 33.5 0.7 5.3e-08 32.6 0.7 1.4 1 0 0 1 1 1 1 GRIP domain ATG16 PF08614.11 VDK84830.1 - 0.016 15.5 3.4 0.016 15.5 3.4 3.1 3 1 0 4 4 4 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 VDK84830.1 - 0.11 12.5 8.8 0.88 9.6 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.6 VDK84830.1 - 0.19 11.5 18.1 0.12 12.2 2.7 2.8 2 1 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH Sec2p PF06428.11 VDK84830.1 - 0.24 11.4 9.9 0.26 11.3 1.4 3.3 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p DUF641 PF04859.12 VDK84830.1 - 0.55 10.6 11.1 1.5 9.1 0.7 3.2 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Fez1 PF06818.15 VDK84830.1 - 0.74 10.2 14.9 10 6.5 14.9 2.4 1 1 0 1 1 1 0 Fez1 Csm1_N PF18504.1 VDK84830.1 - 1.1 9.7 5.9 5.3 7.4 0.7 3.4 2 1 1 3 3 3 0 Csm1 N-terminal domain ENT PF03735.14 VDK84830.1 - 1.4 9.0 7.0 0.19 11.8 0.4 2.7 3 0 0 3 3 3 0 ENT domain DUF2120 PF09893.9 VDK84830.1 - 2.3 8.3 6.1 1.6 8.9 1.0 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) FlaC_arch PF05377.11 VDK84830.1 - 2.5 8.6 6.1 28 5.2 0.0 3.3 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) FAM76 PF16046.5 VDK84830.1 - 3.2 7.0 10.8 3.9 6.7 4.3 2.2 1 1 1 2 2 2 0 FAM76 protein Semialdhyde_dh PF01118.24 VDK84837.1 - 0.048 14.1 0.0 0.048 14.1 0.0 1.2 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain AP_endonuc_2 PF01261.24 VDK84837.1 - 0.1 12.0 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel DEAD PF00270.29 VDK84838.1 - 7e-21 74.8 0.1 1.6e-20 73.6 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK84838.1 - 3.6e-18 65.9 0.0 7.7e-17 61.6 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C2H2 PF00096.26 VDK84838.1 - 2.6e-11 43.3 25.2 7.6e-05 23.0 1.6 4.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type RecQ_Zn_bind PF16124.5 VDK84838.1 - 6.3e-09 36.4 3.2 6.3e-09 36.4 3.2 2.5 2 0 0 2 2 1 1 RecQ zinc-binding zf-H2C2_2 PF13465.6 VDK84838.1 - 1e-07 32.0 15.3 0.00038 20.7 0.1 3.9 3 0 0 3 3 3 2 Zinc-finger double domain ResIII PF04851.15 VDK84838.1 - 6.9e-07 29.4 0.0 1.6e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C2H2_4 PF13894.6 VDK84838.1 - 7.3e-05 23.3 31.6 0.061 14.2 0.5 4.7 5 0 0 5 5 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK84838.1 - 0.0023 18.1 15.3 0.067 13.5 2.6 4.0 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK84838.1 - 0.022 14.7 0.2 0.022 14.7 0.2 4.5 5 0 0 5 5 5 0 C2H2-type zinc finger zf-AN1 PF01428.16 VDK84838.1 - 0.075 13.2 10.7 0.86 9.8 1.4 3.8 3 0 0 3 3 3 0 AN1-like Zinc finger SecA_DEAD PF07517.14 VDK84838.1 - 0.087 12.1 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain ArsA_ATPase PF02374.15 VDK84838.1 - 0.14 11.3 0.4 0.3 10.2 0.3 1.6 1 1 0 1 1 1 0 Anion-transporting ATPase C1_4 PF07975.12 VDK84838.1 - 0.93 9.8 7.9 14 6.0 0.0 2.9 2 0 0 2 2 2 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 VDK84838.1 - 2.1 8.6 7.9 0.21 11.8 1.5 2.7 2 0 0 2 2 2 0 Zinc ribbon domain GPS2_interact PF15784.5 VDK84838.1 - 8.7 6.9 9.4 0.75 10.3 2.8 2.5 3 0 0 3 3 3 0 G-protein pathway suppressor 2-interacting domain RskA PF10099.9 VDK84839.1 - 0.00067 20.0 1.1 0.00082 19.7 1.1 1.1 1 0 0 1 1 1 1 Anti-sigma-K factor rskA MBOAT PF03062.19 VDK84841.1 - 5.3e-29 101.7 16.3 7.3e-29 101.2 16.3 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family ubiquitin PF00240.23 VDK84843.1 - 4.3e-16 58.4 0.1 7.4e-16 57.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family STI1 PF17830.1 VDK84843.1 - 2.5e-09 36.9 13.0 0.00011 22.1 0.7 5.1 3 1 2 5 5 5 2 STI1 domain UBA PF00627.31 VDK84843.1 - 1.6e-08 34.3 0.3 3.7e-08 33.1 0.3 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 VDK84843.1 - 7.5e-07 28.9 0.2 1.3e-06 28.1 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 VDK84843.1 - 0.0082 16.7 0.0 0.17 12.4 0.0 2.7 3 0 0 3 3 3 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 VDK84843.1 - 0.033 14.3 0.0 0.18 11.9 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like XPC-binding PF09280.11 VDK84843.1 - 0.044 13.5 26.2 0.1 12.4 2.1 6.0 3 2 3 6 6 6 0 XPC-binding domain HOIP-UBA PF16678.5 VDK84843.1 - 0.056 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair UBA_6 PF18039.1 VDK84843.1 - 0.085 12.8 0.4 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain SIL1 PF16782.5 VDK84843.1 - 0.12 11.6 0.1 0.26 10.5 0.1 1.5 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 CSTF2_hinge PF14327.6 VDK84843.1 - 4.2 7.9 7.4 3.4 8.2 0.1 3.9 3 1 1 4 4 4 0 Hinge domain of cleavage stimulation factor subunit 2 Mucin PF01456.17 VDK84843.1 - 9.7 6.2 30.0 0.3 11.1 20.6 2.8 3 0 0 3 3 3 0 Mucin-like glycoprotein SNF2_N PF00176.23 VDK84847.1 - 5.7e-66 222.6 1.5 2.2e-64 217.4 1.4 2.4 2 0 0 2 2 2 1 SNF2 family N-terminal domain Chromo PF00385.24 VDK84847.1 - 2e-26 91.6 13.2 2.7e-18 65.6 0.9 4.2 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain CDH1_2_SANT_HL1 PF18375.1 VDK84847.1 - 4.7e-24 84.9 1.0 4.7e-24 84.9 1.0 4.9 5 0 0 5 5 5 1 CDH1/2 SANT-Helical linker 1 Helicase_C PF00271.31 VDK84847.1 - 1.3e-19 70.6 0.0 4.7e-19 68.8 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK84847.1 - 2.1e-10 40.8 0.0 2.1e-10 40.8 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF4208 PF13907.6 VDK84847.1 - 1.8e-09 37.9 0.6 1.8e-09 37.9 0.6 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF4208) Nuc_deoxyri_tr2 PF15891.5 VDK84853.1 - 9.5e-17 61.3 0.0 5.9e-15 55.5 0.0 2.8 3 0 0 3 3 3 1 Nucleoside 2-deoxyribosyltransferase like zf-Tim10_DDP PF02953.15 VDK84854.1 - 5.4e-16 58.0 7.4 6.7e-16 57.7 7.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Band_7 PF01145.25 VDK84855.1 - 7.5e-15 55.4 0.3 1.4e-11 44.7 0.1 2.2 1 1 1 2 2 2 2 SPFH domain / Band 7 family Band_7_1 PF13421.6 VDK84855.1 - 0.062 13.0 0.0 0.098 12.3 0.0 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family IRK_C PF17655.1 VDK84856.1 - 5.4e-45 153.1 0.0 7.4e-45 152.7 0.0 1.2 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain Strumpellin PF10266.9 VDK84859.1 - 2.3e-40 138.3 1.9 2.7e-40 138.0 1.9 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin DUF1674 PF07896.12 VDK84860.1 - 1.7e-18 66.8 5.2 5.4e-18 65.2 5.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Oxysterol_BP PF01237.18 VDK84861.1 - 2.2e-76 257.1 0.0 1.3e-74 251.4 0.0 2.4 1 1 0 1 1 1 1 Oxysterol-binding protein PH PF00169.29 VDK84861.1 - 5e-14 52.7 0.0 1.2e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 VDK84861.1 - 2.6e-08 34.2 1.3 7.9e-07 29.5 1.3 2.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 VDK84861.1 - 3.1e-07 30.6 0.1 7.5e-07 29.3 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 VDK84861.1 - 0.0011 19.0 0.0 0.0033 17.5 0.0 1.8 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 VDK84861.1 - 0.048 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PP2C PF00481.21 VDK84862.1 - 4.5e-33 115.0 0.0 5e-31 108.3 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SSXT PF05030.12 VDK84863.1 - 1.5e-22 79.0 2.8 2.6e-11 43.0 0.0 2.4 2 1 0 2 2 2 2 SSXT protein (N-terminal region) DUF758 PF05527.11 VDK84863.1 - 0.026 14.5 0.0 0.04 13.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF758) ETC_C1_NDUFA4 PF04800.12 VDK84864.1 - 1.8e-35 121.1 0.8 2.5e-35 120.6 0.8 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Fcf1 PF04900.12 VDK84865.1 - 1.2e-35 121.9 2.1 1.2e-35 121.9 2.1 1.6 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 VDK84865.1 - 4.2e-15 56.1 0.3 9.2e-13 48.5 0.0 2.1 2 0 0 2 2 2 2 PIN like domain Flp_N PF03930.14 VDK84865.1 - 0.15 12.1 1.8 1.7 8.7 0.2 2.3 1 1 1 2 2 2 0 Recombinase Flp protein N-terminus PH_17 PF18012.1 VDK84866.1 - 1.7e-20 72.5 0.1 6.5e-19 67.4 0.0 2.3 2 0 0 2 2 2 1 PH domain PDZ PF00595.24 VDK84866.1 - 5e-18 65.2 0.8 9.1e-18 64.4 0.8 1.5 1 0 0 1 1 1 1 PDZ domain PH PF00169.29 VDK84866.1 - 2.3e-13 50.5 0.1 1.4e-08 35.2 0.0 2.6 2 1 0 2 2 2 2 PH domain PDZ_6 PF17820.1 VDK84866.1 - 1.2e-07 31.5 0.1 2.4e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK84866.1 - 0.00044 20.5 0.1 0.00079 19.7 0.1 1.4 1 0 0 1 1 1 1 PDZ domain IPK PF03770.16 VDK84867.1 - 8.6e-48 162.8 0.0 1.4e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase TPT PF03151.16 VDK84868.1 - 5.6e-15 55.4 10.2 7.2e-15 55.1 10.2 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 VDK84868.1 - 2.7e-08 34.1 27.6 4.5e-05 23.6 12.8 3.1 3 0 0 3 3 3 3 EamA-like transporter family PUNUT PF16913.5 VDK84868.1 - 0.00051 19.4 4.5 0.00051 19.4 4.5 2.4 2 1 0 2 2 2 1 Purine nucleobase transmembrane transport DUF4748 PF15932.5 VDK84868.1 - 0.092 12.5 0.7 1 9.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) Tlr3_TMD PF17968.1 VDK84868.1 - 1.1 9.5 6.7 0.21 11.8 1.4 2.6 2 0 0 2 2 2 0 Toll-like receptor 3 trans-membrane domain ALIX_LYPXL_bnd PF13949.6 VDK84872.1 - 6.4e-70 235.8 17.4 5e-68 229.6 13.2 2.8 2 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV BRO1 PF03097.18 VDK84872.1 - 6.3e-40 137.2 0.3 6.3e-40 137.2 0.3 2.2 2 0 0 2 2 2 1 BRO1-like domain BRO1 PF03097.18 VDK84874.1 - 2.6e-45 154.9 0.1 2.8e-45 154.8 0.1 1.0 1 0 0 1 1 1 1 BRO1-like domain SEA PF01390.20 VDK84875.1 - 8.3e-10 38.7 0.1 0.00017 21.6 0.0 2.6 2 0 0 2 2 2 2 SEA domain gpUL132 PF11359.8 VDK84883.1 - 0.021 14.4 1.7 4.1 6.9 0.0 3.7 4 0 0 4 4 4 0 Glycoprotein UL132 Ribosomal_L7Ae PF01248.26 VDK84884.1 - 6.3e-23 80.3 0.1 1.5e-22 79.2 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 VDK84884.1 - 0.04 14.0 0.0 0.055 13.5 0.0 1.2 1 0 0 1 1 1 0 RNase P subunit Pop3 OPA3 PF07047.12 VDK84884.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) SOG2 PF10428.9 VDK84894.1 - 0.012 14.9 8.7 0.014 14.6 8.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Trehalase PF01204.18 VDK84895.1 - 1.9e-135 452.6 3.2 2.3e-135 452.3 3.2 1.0 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 VDK84895.1 - 0.011 14.7 0.7 0.049 12.6 0.7 2.1 1 1 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Trehalase PF01204.18 VDK84897.1 - 1.9e-142 475.7 8.4 2.3e-142 475.5 8.4 1.0 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 VDK84897.1 - 0.00038 19.5 0.6 0.0023 16.9 0.6 2.1 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Glyco_hydro_63 PF03200.16 VDK84897.1 - 0.049 12.4 3.8 1 8.1 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 63 C-terminal domain zf-MYND PF01753.18 VDK84902.1 - 2.3e-05 24.4 14.4 2.3e-05 24.4 14.4 3.8 3 1 0 3 3 3 1 MYND finger TPR_12 PF13424.6 VDK84902.1 - 0.0029 17.9 0.0 0.017 15.4 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDK84902.1 - 0.12 12.2 0.3 0.35 10.8 0.3 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat FYDLN_acid PF09538.10 VDK84902.1 - 0.59 10.8 3.3 2.7 8.7 1.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (FYDLN_acid) ATP_Ca_trans_C PF12424.8 VDK84903.1 - 0.00018 21.9 0.2 0.00029 21.2 0.2 1.6 1 1 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal ATP_Ca_trans_C PF12424.8 VDK84906.1 - 0.00018 21.9 0.2 0.00029 21.2 0.2 1.6 1 1 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal zf-MYND PF01753.18 VDK84907.1 - 2.3e-05 24.4 14.4 2.3e-05 24.4 14.4 3.8 3 1 0 3 3 3 1 MYND finger TPR_12 PF13424.6 VDK84907.1 - 0.0029 17.9 0.0 0.017 15.4 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDK84907.1 - 0.12 12.2 0.3 0.35 10.8 0.3 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat FYDLN_acid PF09538.10 VDK84907.1 - 0.59 10.8 3.3 2.7 8.7 1.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (FYDLN_acid) UEV PF05743.13 VDK84909.1 - 1.2e-35 122.0 0.0 2.4e-35 121.0 0.0 1.5 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 VDK84909.1 - 3e-21 75.1 0.1 5.7e-21 74.2 0.1 1.5 1 0 0 1 1 1 1 Vps23 core domain Vps54_N PF10475.9 VDK84909.1 - 0.056 12.7 2.4 0.082 12.2 2.4 1.2 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex CENP-F_leu_zip PF10473.9 VDK84909.1 - 0.1 12.6 1.9 0.17 11.9 1.9 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4058 PF13267.6 VDK84909.1 - 3.3 7.0 5.1 1 8.7 0.7 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF4058) zf-C2H2_4 PF13894.6 VDK84910.1 - 0.068 14.0 8.6 1.4 10.0 0.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-FCS PF06467.14 VDK84910.1 - 0.079 12.9 5.7 3.6 7.6 0.2 2.3 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2 PF00096.26 VDK84910.1 - 0.36 11.4 6.5 5.1 7.7 0.2 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type DnaJ PF00226.31 VDK84911.1 - 4.7e-18 65.1 1.2 1.4e-17 63.5 1.2 1.9 1 0 0 1 1 1 1 DnaJ domain SP24 PF16504.5 VDK84911.1 - 0.012 15.7 0.7 2.5 8.1 0.2 2.4 2 0 0 2 2 2 0 Putative virion membrane protein of plant and insect virus PTS_IIB PF02302.17 VDK84911.1 - 0.1 13.3 0.5 42 4.9 0.0 3.0 3 0 0 3 3 3 0 PTS system, Lactose/Cellobiose specific IIB subunit Sec61_beta PF03911.16 VDK84911.1 - 0.17 12.0 0.4 0.34 11.0 0.4 1.4 1 0 0 1 1 1 0 Sec61beta family COX14 PF14880.6 VDK84911.1 - 0.89 9.4 0.0 0.89 9.4 0.0 4.0 4 0 0 4 4 4 0 Cytochrome oxidase c assembly Peptidase_S49_N PF08496.10 VDK84911.1 - 5.9 6.9 8.0 0.35 10.9 0.6 2.3 3 0 0 3 3 3 0 Peptidase family S49 N-terminal CCDC53 PF10152.9 VDK84912.1 - 0.00044 20.7 0.2 0.00053 20.4 0.2 1.1 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex NPV_P10 PF05531.12 VDK84912.1 - 0.026 15.0 0.1 0.65 10.5 0.0 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Methyltransf_11 PF08241.12 VDK84914.1 - 3.2e-14 53.3 0.2 4.9e-14 52.8 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK84914.1 - 3.4e-13 49.7 0.0 4.6e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK84914.1 - 8.9e-12 45.6 0.3 3.9e-11 43.5 0.2 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK84914.1 - 5.5e-11 42.5 0.0 7.4e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK84914.1 - 3.9e-08 33.9 0.0 6.2e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 VDK84914.1 - 4.4e-06 26.2 0.0 5.9e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 VDK84914.1 - 0.00019 21.1 0.1 0.00027 20.6 0.1 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) PrmA PF06325.13 VDK84914.1 - 0.00023 20.6 0.0 0.00032 20.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 VDK84914.1 - 0.00034 20.2 0.0 0.00055 19.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 VDK84914.1 - 0.0028 17.1 0.0 0.0036 16.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 VDK84914.1 - 0.016 15.2 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 VDK84914.1 - 0.019 14.4 0.0 0.03 13.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB GDI PF00996.18 VDK84915.1 - 1.4e-223 742.2 0.1 1.6e-223 742.0 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor YodL PF14191.6 VDK84915.1 - 0.11 13.4 0.0 2 9.3 0.0 2.5 2 0 0 2 2 2 0 YodL-like SH3_14 PF18343.1 VDK84915.1 - 0.13 12.4 0.8 21 5.2 0.0 2.9 3 1 0 3 3 3 0 Dda helicase SH3 domain DUF5641 PF18701.1 VDK84920.1 - 0.0075 16.4 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5641) Ank_2 PF12796.7 VDK84921.1 - 2e-37 127.6 16.1 5.4e-12 46.1 0.3 5.0 3 1 5 8 8 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK84921.1 - 6.5e-30 103.1 7.7 1.4e-07 31.9 0.1 6.7 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 VDK84921.1 - 9.3e-29 98.6 8.2 0.00029 21.1 0.3 9.1 8 1 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 VDK84921.1 - 4.3e-28 97.0 8.9 2.3e-09 37.3 0.3 6.6 5 1 1 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK84921.1 - 1e-16 59.3 14.9 0.00012 22.2 0.2 9.4 9 1 0 9 9 9 3 Ankyrin repeat zf-C3HC4_3 PF13920.6 VDK84921.1 - 3.7e-14 52.3 28.5 4.4e-08 32.8 6.5 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK84921.1 - 1.6e-07 31.0 26.9 1.9e-05 24.4 5.7 2.6 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 VDK84921.1 - 0.04 13.9 29.8 0.52 10.3 15.3 2.7 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 VDK84921.1 - 0.058 13.2 29.6 0.46 10.4 13.9 3.4 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK84921.1 - 0.24 11.3 26.7 0.32 10.9 5.5 3.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) TerY_C PF15616.6 VDK84921.1 - 9.8 6.3 15.8 2.4 8.3 4.2 2.6 2 0 0 2 2 2 0 TerY-C metal binding domain RBR PF17208.3 VDK84922.1 - 0.027 15.2 5.3 3.8 8.3 0.5 2.7 2 0 0 2 2 2 0 RNA binding Region NICE-1 PF15845.5 VDK84922.1 - 0.051 14.4 1.5 0.12 13.2 1.5 1.5 1 0 0 1 1 1 0 Cysteine-rich C-terminal 1 family Det1 PF09737.9 VDK84923.1 - 0.081 12.0 0.1 0.081 12.0 0.1 1.2 1 0 0 1 1 1 0 De-etiolated protein 1 Det1 Pkinase PF00069.25 VDK84927.1 - 4.2e-36 124.7 0.0 1.1e-34 120.0 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK84927.1 - 5.8e-35 120.8 0.0 1.9e-30 106.0 0.0 3.3 4 0 0 4 4 4 2 Protein tyrosine kinase FTA2 PF13095.6 VDK84927.1 - 0.16 11.6 0.0 8.4 5.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Bax1-I PF01027.20 VDK84928.1 - 5.5e-32 111.3 15.5 9.5e-32 110.5 15.5 1.4 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 LSM PF01423.22 VDK84928.1 - 6.8e-07 28.9 0.0 1.4e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 LSM domain Myotub-related PF06602.14 VDK84929.1 - 1.9e-137 457.9 0.2 2.5e-137 457.5 0.2 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 VDK84929.1 - 3.5e-11 43.0 0.0 7.7e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DSPc PF00782.20 VDK84929.1 - 3.9e-05 23.5 0.0 9.7e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain 3-PAP PF12578.8 VDK84929.1 - 0.00045 20.0 0.5 0.018 14.8 0.0 2.8 3 0 0 3 3 3 1 Myotubularin-associated protein Y_phosphatase PF00102.27 VDK84929.1 - 0.00097 18.8 0.0 0.0022 17.6 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 VDK84929.1 - 0.0078 16.2 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Cse1 PF08506.10 VDK84930.1 - 3.2e-116 388.2 9.2 1.2e-115 386.2 9.2 2.0 1 1 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 VDK84930.1 - 3.9e-59 200.3 2.1 3.9e-59 200.3 2.1 1.8 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 VDK84930.1 - 2.5e-11 43.3 0.0 7.9e-11 41.7 0.0 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain Xpo1 PF08389.12 VDK84930.1 - 0.014 15.5 7.9 0.024 14.7 0.8 3.8 4 0 0 4 4 4 0 Exportin 1-like protein DUF3177 PF11375.8 VDK84930.1 - 0.02 14.6 0.2 0.058 13.2 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3177) Activin_recp PF01064.23 VDK84932.1 - 0.051 14.7 10.1 0.11 13.6 10.1 1.6 1 1 0 1 1 1 0 Activin types I and II receptor domain DUF2642 PF10842.8 VDK84934.1 - 0.15 12.0 0.2 0.21 11.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2642) ANAPC3 PF12895.7 VDK84935.1 - 0.01 16.1 1.6 0.018 15.2 1.6 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 VDK84935.1 - 0.033 14.7 0.0 0.055 14.0 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Cadherin PF00028.17 VDK84943.1 - 4.9e-50 167.9 0.9 1.3e-13 51.2 0.0 6.0 6 1 2 8 8 8 5 Cadherin domain Oscp1 PF10188.9 VDK84945.1 - 1.4e-53 181.6 2.6 2e-53 181.1 2.6 1.2 1 0 0 1 1 1 1 Organic solute transport protein 1 Cadherin PF00028.17 VDK84946.1 - 1.1e-201 654.0 22.3 6.3e-21 74.6 0.1 18.6 19 0 0 19 19 19 17 Cadherin domain Cadherin_pro PF08758.11 VDK84946.1 - 6.9e-16 58.2 0.3 1.9e-05 24.7 0.0 8.8 11 0 0 11 11 11 3 Cadherin prodomain like Cadherin_2 PF08266.12 VDK84946.1 - 2.3e-11 43.3 0.0 13 5.7 0.0 10.5 12 0 0 12 12 12 2 Cadherin-like Cadherin_3 PF16184.5 VDK84946.1 - 3.2e-09 36.7 17.4 1.4 8.9 0.0 11.4 14 0 0 14 14 14 3 Cadherin-like RET_CLD1 PF17756.1 VDK84946.1 - 2.5e-07 31.0 2.4 2.6 8.4 0.0 8.9 10 1 0 10 10 10 1 RET Cadherin like domain 1 Y_Y_Y PF07495.13 VDK84946.1 - 0.084 12.8 0.0 75 3.4 0.0 4.9 4 0 0 4 4 4 0 Y_Y_Y domain Promethin PF16015.5 VDK84946.1 - 0.089 12.7 0.8 0.17 11.8 0.8 1.3 1 0 0 1 1 1 0 Promethin Shugoshin_N PF07558.11 VDK84951.1 - 0.025 14.4 2.1 0.059 13.3 2.1 1.7 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region CARD_2 PF16739.5 VDK84951.1 - 0.57 10.2 3.8 2.3 8.3 3.2 2.3 1 1 1 2 2 2 0 Caspase recruitment domain SNCAIP_SNCA_bd PF16700.5 VDK84951.1 - 0.81 9.5 6.5 0.33 10.7 2.4 2.5 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain PID PF00640.23 VDK84952.1 - 0.017 15.2 0.1 0.029 14.4 0.1 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) PID PF00640.23 VDK84953.1 - 2.9e-12 46.8 0.0 3.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PRKCSH PF07915.13 VDK84962.1 - 6.7e-13 49.4 3.2 6.7e-13 49.4 3.2 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 VDK84962.1 - 0.00075 19.2 0.7 0.00075 19.2 0.7 1.9 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein Ham1p_like PF01725.16 VDK84963.1 - 4.5e-50 170.2 0.0 5.4e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Bac_surface_Ag PF01103.23 VDK84966.1 - 6.9e-33 114.5 0.3 1e-32 113.9 0.3 1.3 1 0 0 1 1 1 1 Surface antigen ShlB PF03865.13 VDK84966.1 - 0.055 12.9 0.5 0.3 10.5 0.0 2.0 2 0 0 2 2 2 0 Haemolysin secretion/activation protein ShlB/FhaC/HecB HSP20 PF00011.21 VDK84969.1 - 4.2e-20 71.8 1.0 6.5e-20 71.2 0.1 1.6 2 0 0 2 2 2 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK84969.1 - 0.0025 17.3 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA zf-C2H2_4 PF13894.6 VDK84970.1 - 0.0094 16.7 26.8 0.32 12.0 1.7 4.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK84970.1 - 0.033 14.7 21.7 0.2 12.2 1.7 4.9 4 0 0 4 4 4 0 Zinc finger, C2H2 type GAGA PF09237.11 VDK84970.1 - 0.038 13.8 0.2 0.13 12.1 0.1 1.9 2 0 0 2 2 2 0 GAGA factor zf-C2H2_jaz PF12171.8 VDK84970.1 - 0.84 10.0 11.1 10 6.5 0.6 4.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding TIL PF01826.17 VDK84971.1 - 8.2e-07 29.2 20.6 1.1e-06 28.8 20.6 1.2 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain TIL PF01826.17 VDK84972.1 - 3.6e-06 27.1 14.4 4.6e-06 26.8 14.4 1.1 1 0 0 1 1 1 1 Trypsin Inhibitor like cysteine rich domain Ig_2 PF13895.6 VDK84978.1 - 5e-08 33.2 0.1 0.0025 18.1 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain Ig_3 PF13927.6 VDK84978.1 - 8.6e-08 32.7 0.3 0.013 16.1 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin domain I-set PF07679.16 VDK84978.1 - 1.7e-06 28.0 0.3 0.016 15.2 0.1 2.1 2 0 0 2 2 2 2 Immunoglobulin I-set domain ig PF00047.25 VDK84978.1 - 6.2e-06 26.3 0.3 0.071 13.3 0.0 2.2 2 0 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 VDK84978.1 - 4e-05 23.7 0.1 0.058 13.6 0.0 2.1 2 0 0 2 2 2 2 Immunoglobulin V-set domain Ig_6 PF18452.1 VDK84978.1 - 0.047 13.3 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Pro_isomerase PF00160.21 VDK84979.1 - 7.8e-49 166.0 0.1 7.8e-49 166.0 0.1 1.5 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD fn3 PF00041.21 VDK84980.1 - 2.2e-23 82.4 4.5 4.5e-08 33.3 0.1 4.2 5 0 0 5 5 5 3 Fibronectin type III domain I-set PF07679.16 VDK84980.1 - 0.0001 22.3 0.0 0.0011 19.0 0.0 2.4 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK84980.1 - 0.0018 18.8 0.0 0.01 16.4 0.0 2.4 1 0 0 1 1 1 1 Immunoglobulin domain Ig_2 PF13895.6 VDK84980.1 - 0.0065 16.8 0.3 0.11 12.8 0.0 2.7 2 0 0 2 2 2 1 Immunoglobulin domain ig PF00047.25 VDK84980.1 - 0.094 12.9 0.0 0.3 11.3 0.0 1.8 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 VDK84980.1 - 0.12 12.6 0.4 4.7 7.4 0.0 3.2 4 0 0 4 4 4 0 Immunoglobulin V-set domain DAO PF01266.24 VDK84981.1 - 2.2e-50 172.2 0.2 4e-48 164.8 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase DAO_C PF16901.5 VDK84981.1 - 1.1e-40 138.3 0.1 2.2e-40 137.4 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase EF-hand_7 PF13499.6 VDK84981.1 - 2.8e-11 43.7 1.6 6.6e-11 42.5 1.6 1.7 1 0 0 1 1 1 1 EF-hand domain pair FAD_binding_2 PF00890.24 VDK84981.1 - 1.7e-08 34.0 2.7 0.00015 21.0 1.1 2.3 2 0 0 2 2 2 2 FAD binding domain EF-hand_1 PF00036.32 VDK84981.1 - 3.3e-08 32.5 0.1 0.0045 16.5 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 VDK84981.1 - 3.4e-07 29.7 1.5 0.0047 16.8 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain Pyr_redox_2 PF07992.14 VDK84981.1 - 4.4e-06 26.2 0.4 0.0078 15.5 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_8 PF13833.6 VDK84981.1 - 0.00011 22.0 0.5 0.0004 20.2 0.3 2.1 1 1 1 2 2 2 1 EF-hand domain pair FAD_oxidored PF12831.7 VDK84981.1 - 0.00094 18.6 2.2 0.00099 18.6 0.5 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 VDK84981.1 - 0.0016 17.6 0.4 0.031 13.4 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A EF-hand_5 PF13202.6 VDK84981.1 - 0.0091 15.5 0.3 0.61 9.7 0.0 3.2 3 0 0 3 3 3 1 EF hand DUF5580 PF17743.1 VDK84981.1 - 0.01 14.5 0.2 0.015 13.9 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Pyr_redox PF00070.27 VDK84981.1 - 0.011 16.3 0.5 2.6 8.7 0.2 2.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 VDK84981.1 - 0.036 14.5 0.5 9.4 6.7 0.1 2.9 1 1 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 VDK84981.1 - 0.052 12.2 0.2 0.15 10.7 0.2 1.8 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox_3 PF13738.6 VDK84981.1 - 0.073 12.3 0.4 1.3 8.2 0.1 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF771 PF05595.11 VDK84981.1 - 0.11 12.5 0.1 0.28 11.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF771) NAD_binding_8 PF13450.6 VDK84981.1 - 0.34 11.2 3.1 0.72 10.1 0.3 2.8 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain zf-A20 PF01754.16 VDK84982.1 - 7.8e-13 48.1 6.2 7.8e-13 48.1 6.2 2.4 3 0 0 3 3 3 1 A20-like zinc finger zf-AN1 PF01428.16 VDK84982.1 - 6.1e-09 35.9 7.6 6.1e-09 35.9 7.6 2.5 2 0 0 2 2 2 1 AN1-like Zinc finger zf-C5HC2 PF02928.16 VDK84982.1 - 0.049 14.0 6.1 0.051 14.0 3.8 2.2 2 0 0 2 2 2 0 C5HC2 zinc finger DUF3185 PF11381.8 VDK84991.1 - 0.16 12.0 0.1 0.29 11.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) ADK PF00406.22 VDK84992.1 - 9.3e-53 178.4 0.0 1.1e-52 178.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 VDK84992.1 - 6.9e-37 126.9 0.1 8.9e-37 126.5 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 VDK84992.1 - 1.3e-05 25.4 0.0 2.4e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 VDK84992.1 - 0.00031 21.3 0.0 0.0005 20.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 VDK84992.1 - 0.024 14.3 0.1 2.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase Gln-synt_N PF03951.19 VDK84993.1 - 0.079 12.7 0.3 0.14 11.9 0.3 1.3 1 0 0 1 1 1 0 Glutamine synthetase, beta-Grasp domain Bud13 PF09736.9 VDK84995.1 - 7.2e-41 140.0 15.2 7.2e-41 140.0 15.2 4.5 4 1 0 4 4 4 1 Pre-mRNA-splicing factor of RES complex Serine_rich PF08824.10 VDK84995.1 - 0.29 11.1 2.7 0.84 9.6 2.7 1.8 1 0 0 1 1 1 0 Serine rich protein interaction domain DAD PF02109.16 VDK84996.1 - 5.7e-44 148.9 3.8 6.2e-44 148.8 3.8 1.0 1 0 0 1 1 1 1 DAD family DUF3278 PF11683.8 VDK84996.1 - 0.0019 18.3 0.8 0.0029 17.7 0.4 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF3278) BaxI_1 PF12811.7 VDK84996.1 - 0.046 13.3 0.9 0.062 12.9 0.9 1.2 1 0 0 1 1 1 0 Bax inhibitor 1 like DUF4389 PF14333.6 VDK84996.1 - 0.08 12.9 0.4 0.08 12.9 0.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) Cyt_b-c1_8 PF10890.8 VDK84996.1 - 0.12 12.7 0.1 0.21 12.0 0.1 1.3 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 DUF2207 PF09972.9 VDK84996.1 - 0.16 10.7 0.3 0.17 10.6 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Zip PF02535.22 VDK84997.1 - 3.9e-74 249.8 12.4 3.9e-74 249.8 12.4 2.0 2 0 0 2 2 2 1 ZIP Zinc transporter TMEM237 PF15383.6 VDK84997.1 - 0.52 9.4 2.9 1.3 8.1 0.1 2.3 2 0 0 2 2 2 0 Transmembrane protein 237 DUF3267 PF11667.8 VDK84997.1 - 1 9.7 6.9 0.16 12.2 0.4 2.5 2 1 0 2 2 2 0 Putative zincin peptidase TMEM132D_C PF15706.5 VDK84997.1 - 1.6 8.5 0.0 1.6 8.5 0.0 3.1 2 2 1 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term V_ATPase_I PF01496.19 VDK84997.1 - 2.1 6.1 12.4 0.7 7.7 8.0 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family HeH PF12949.7 VDK84997.1 - 4.2 7.2 6.4 1 9.1 0.1 2.6 3 0 0 3 3 3 0 HeH/LEM domain AAA PF00004.29 VDK84998.1 - 2e-15 57.4 0.0 5.3e-15 56.0 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 VDK84998.1 - 1.1e-12 48.0 0.0 1.6e-11 44.3 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 VDK84998.1 - 4.5e-07 30.2 0.0 0.0021 18.4 0.0 2.8 1 1 1 2 2 2 2 Replication factor C C-terminal domain Rad17 PF03215.15 VDK84998.1 - 2.5e-06 27.5 0.0 4.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_24 PF13479.6 VDK84998.1 - 3.9e-05 23.5 0.0 6.9e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 VDK84998.1 - 4.3e-05 23.8 0.0 0.00046 20.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK84998.1 - 4.8e-05 23.8 0.0 0.001 19.5 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 VDK84998.1 - 0.0012 18.7 0.0 0.0022 17.9 0.0 1.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 VDK84998.1 - 0.0015 18.3 0.0 0.0026 17.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 VDK84998.1 - 0.0018 18.6 0.0 0.005 17.2 0.0 1.8 2 0 0 2 2 1 1 AAA C-terminal domain TIP49 PF06068.13 VDK84998.1 - 0.0022 17.3 0.0 0.0033 16.7 0.0 1.4 1 1 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 VDK84998.1 - 0.0038 17.6 0.0 0.0088 16.4 0.0 1.8 1 1 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 VDK84998.1 - 0.0048 16.6 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 VDK84998.1 - 0.0049 17.0 0.0 0.0084 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 VDK84998.1 - 0.005 16.2 0.0 0.06 12.7 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 VDK84998.1 - 0.011 15.5 0.0 0.021 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 VDK84998.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 VDK84998.1 - 0.015 14.5 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DEAD PF00270.29 VDK84998.1 - 0.016 15.0 0.1 5.9 6.6 0.0 2.5 2 1 1 3 3 2 0 DEAD/DEAH box helicase DUF2075 PF09848.9 VDK84998.1 - 0.017 14.4 0.0 0.058 12.6 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 VDK84998.1 - 0.023 14.7 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 VDK84998.1 - 0.027 14.1 0.0 0.07 12.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 VDK84998.1 - 0.042 13.8 0.0 0.17 11.9 0.0 2.0 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 VDK84998.1 - 0.044 14.3 0.0 0.12 13.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 VDK84998.1 - 0.054 12.9 0.0 0.91 8.9 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 VDK84998.1 - 0.063 13.6 0.0 0.57 10.5 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 VDK84998.1 - 0.083 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_2 PF07724.14 VDK84998.1 - 0.087 12.9 0.0 0.41 10.7 0.0 2.1 2 1 1 3 3 2 0 AAA domain (Cdc48 subfamily) AAA_28 PF13521.6 VDK84998.1 - 0.11 12.7 0.0 0.28 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 VDK84998.1 - 0.13 11.7 0.0 1.3 8.4 0.0 2.3 1 1 0 1 1 1 0 Bacterial TniB protein Homeodomain PF00046.29 VDK84999.1 - 1.4e-17 63.3 0.2 1.4e-17 63.3 0.2 1.7 2 0 0 2 2 2 1 Homeodomain LIM PF00412.22 VDK84999.1 - 3.2e-15 56.1 8.4 5.6e-15 55.3 8.4 1.4 1 0 0 1 1 1 1 LIM domain Homeobox_KN PF05920.11 VDK84999.1 - 0.0034 17.3 0.0 0.0094 15.8 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Sgf11 PF08209.11 VDK84999.1 - 0.056 13.0 4.1 1.8 8.2 0.3 2.5 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) HypA PF01155.19 VDK84999.1 - 0.3 11.1 4.8 0.1 12.6 1.9 1.7 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-SNAP50_C PF12251.8 VDK84999.1 - 1.7 8.2 8.5 0.42 10.2 4.5 1.8 1 1 1 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal FAD-SLDH PF12318.8 VDK85006.1 - 0.14 12.2 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase HLH PF00010.26 VDK85007.1 - 6e-11 42.1 4.0 6.5e-11 42.0 2.9 1.7 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Myf5 PF12232.8 VDK85007.1 - 0.076 13.8 0.2 0.22 12.3 0.2 1.9 1 0 0 1 1 1 0 Myogenic determination factor 5 MCPVI PF02993.14 VDK85007.1 - 0.46 10.3 2.7 0.73 9.6 1.7 1.8 1 1 0 1 1 1 0 Minor capsid protein VI PAX PF00292.18 VDK85008.1 - 4.4e-15 55.7 0.2 6.4e-15 55.2 0.2 1.3 1 0 0 1 1 1 1 'Paired box' domain HTH_23 PF13384.6 VDK85008.1 - 1.7e-08 34.0 0.1 2.7e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.6 VDK85008.1 - 5.9e-08 32.3 0.4 1.1e-07 31.5 0.4 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.6 VDK85008.1 - 2.3e-06 27.6 0.1 3.9e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.15 VDK85008.1 - 1.5e-05 24.9 0.2 2.7e-05 24.1 0.2 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_29 PF13551.6 VDK85008.1 - 0.0075 16.3 0.1 0.014 15.4 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn helix CENP-B_N PF04218.13 VDK85008.1 - 0.0089 15.6 0.3 0.037 13.7 0.2 1.9 1 1 1 2 2 2 1 CENP-B N-terminal DNA-binding domain Terminase_5 PF06056.12 VDK85008.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_50 PF18024.1 VDK85008.1 - 0.069 12.8 0.5 0.57 9.8 0.4 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_40 PF14493.6 VDK85008.1 - 0.14 12.6 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Tnp_1 PF01527.20 VDK85008.1 - 0.16 12.3 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Transposase Y_phosphatase PF00102.27 VDK85010.1 - 5.4e-21 75.2 0.9 8.2e-21 74.6 0.2 1.6 1 1 1 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 VDK85010.1 - 0.00021 21.3 0.1 0.00037 20.6 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 VDK85010.1 - 0.00044 20.1 0.3 0.00071 19.4 0.2 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Phi-29_GP16_7 PF06720.11 VDK85010.1 - 0.016 15.0 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 PTPlike_phytase PF14566.6 VDK85010.1 - 0.14 12.3 0.3 0.24 11.5 0.1 1.5 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 VDK85011.1 - 2e-39 135.6 1.9 3e-39 135.0 1.9 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase ANAPC3 PF12895.7 VDK85012.1 - 1.4e-05 25.2 4.2 7.8e-05 22.8 0.3 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 VDK85012.1 - 2.9e-05 23.7 12.7 0.0019 17.9 0.4 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK85012.1 - 7.8e-05 22.6 3.1 0.02 15.1 0.5 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK85012.1 - 0.0039 17.7 2.4 0.037 14.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK85012.1 - 0.0064 16.5 10.9 0.09 12.9 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK85012.1 - 0.029 14.5 0.1 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK85012.1 - 0.11 12.6 1.7 1.5 9.0 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK85012.1 - 0.15 12.5 2.7 0.33 11.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK85012.1 - 0.64 10.8 0.1 0.64 10.8 0.1 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Ribosomal_S6e PF01092.19 VDK85013.1 - 0.15 12.1 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein S6e Ras PF00071.22 VDK85015.1 - 4.2e-14 52.4 0.0 1.3e-13 50.9 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 VDK85015.1 - 0.00022 21.4 0.2 0.0073 16.5 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SelP_N PF04592.14 VDK85016.1 - 0.022 14.2 26.6 0.065 12.6 11.5 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region TCP PF03634.13 VDK85016.1 - 3.4 8.2 13.8 5.9 7.4 2.8 2.3 2 0 0 2 2 2 0 TCP family transcription factor Androgen_recep PF02166.16 VDK85016.1 - 4.8 5.9 19.7 0.048 12.5 5.3 2.4 2 0 0 2 2 2 0 Androgen receptor Ribosomal_L32e PF01655.18 VDK85030.1 - 0.049 14.0 0.1 0.11 13.0 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L32 DUF2408 PF10303.9 VDK85030.1 - 0.059 13.9 9.5 0.045 14.3 5.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) DUF3683 PF12447.8 VDK85030.1 - 1 9.5 5.7 0.5 10.5 0.2 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF3683) DASH_Duo1 PF08651.10 VDK85030.1 - 1.8 8.4 7.4 0.99 9.2 0.4 3.5 2 2 1 4 4 4 0 DASH complex subunit Duo1 Collagen PF01391.18 VDK85033.1 - 1.5e-24 85.5 91.7 2.6e-09 36.7 31.7 4.2 2 1 2 4 4 4 4 Collagen triple helix repeat (20 copies) Mitofilin PF09731.9 VDK85034.1 - 4.9 5.9 48.2 6.2 5.5 48.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Voldacs PF03517.13 VDK85035.1 - 3.9e-29 101.5 1.5 3.9e-29 101.5 1.5 1.6 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling CAP_N PF01213.19 VDK85036.1 - 7.2 6.0 12.4 12 5.3 12.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Taxilin PF09728.9 VDK85037.1 - 1.7e-42 145.7 40.1 2.3e-42 145.3 40.1 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein Cortex-I_coil PF09304.10 VDK85037.1 - 0.0048 17.1 6.1 0.0048 17.1 6.1 3.6 1 1 3 4 4 4 2 Cortexillin I, coiled coil Ubiquitin_3 PF14836.6 VDK85037.1 - 0.082 12.9 0.3 0.082 12.9 0.3 2.4 1 1 1 3 3 3 0 Ubiquitin-like domain UPF0242 PF06785.11 VDK85037.1 - 0.093 12.8 32.8 0.36 10.9 9.4 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Laminin_II PF06009.12 VDK85037.1 - 1.3 9.1 21.4 0.077 13.0 2.0 3.6 1 1 3 4 4 4 0 Laminin Domain II Spc7 PF08317.11 VDK85037.1 - 1.7 7.4 35.4 0.11 11.3 19.0 2.8 1 1 1 2 2 2 0 Spc7 kinetochore protein OMS28_porin PF03532.13 VDK85037.1 - 2.3 7.4 13.0 0.77 8.9 3.8 2.1 1 1 1 2 2 2 0 OMS28 porin GAS PF13851.6 VDK85037.1 - 7.7 5.8 39.2 2.8 7.3 10.2 2.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Rootletin PF15035.6 VDK85037.1 - 8.8 6.3 29.4 0.15 12.0 6.8 2.5 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF1664 PF07889.12 VDK85037.1 - 8.9 6.4 17.1 5.5 7.0 3.0 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Sulfate_transp PF00916.20 VDK85038.1 - 0.12 11.1 0.1 0.16 10.7 0.1 1.1 1 0 0 1 1 1 0 Sulfate permease family LRR_12 PF18837.1 VDK85038.1 - 0.86 9.3 4.0 10 5.8 0.0 3.0 3 0 0 3 3 3 0 Leucine-rich repeat DUF2207 PF09972.9 VDK85039.1 - 0.048 12.4 0.2 0.047 12.5 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HECA PF15353.6 VDK85039.1 - 0.15 12.3 1.6 0.38 11.0 1.6 1.7 1 1 0 1 1 1 0 Headcase protein family homologue DUF4512 PF14975.6 VDK85040.1 - 4.2e-07 30.6 2.8 5.7e-07 30.2 2.8 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4512) DUF4187 PF13821.6 VDK85040.1 - 2.3 8.1 5.4 3.8 7.4 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) Methyltr_RsmB-F PF01189.17 VDK85041.1 - 1.4e-38 132.6 0.5 1.1e-37 129.7 0.0 2.3 2 1 1 3 3 3 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 VDK85041.1 - 0.0018 18.1 0.0 0.004 17.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Acyl_transf_2 PF02273.15 VDK85041.1 - 0.0052 16.1 0.0 0.013 14.8 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase FumaraseC_C PF10415.9 VDK85041.1 - 0.007 16.8 0.7 0.021 15.2 0.1 2.1 2 0 0 2 2 2 1 Fumarase C C-terminus FtsJ PF01728.19 VDK85041.1 - 0.015 15.4 0.5 0.041 14.0 0.1 2.0 2 1 0 2 2 2 0 FtsJ-like methyltransferase MRG PF05712.13 VDK85041.1 - 0.021 14.2 0.9 0.083 12.2 0.1 2.3 2 0 0 2 2 2 0 MRG Ubie_methyltran PF01209.18 VDK85041.1 - 0.032 13.6 0.0 0.068 12.5 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Fibrillarin PF01269.17 VDK85041.1 - 0.082 12.0 0.0 0.19 10.8 0.0 1.6 1 1 0 1 1 1 0 Fibrillarin Zona_pellucida PF00100.23 VDK85043.1 - 9.9e-14 51.8 4.0 1.2e-13 51.5 4.0 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain TUDOR PF00567.24 VDK85045.1 - 0.00012 22.1 0.0 0.00023 21.2 0.0 1.5 1 0 0 1 1 1 1 Tudor domain DUF2599 PF10783.9 VDK85045.1 - 0.036 14.7 0.1 0.094 13.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2599) zf-CCCH PF00642.24 VDK85050.1 - 3.5e-09 36.3 1.6 3.5e-09 36.3 1.6 1.8 2 0 0 2 2 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 VDK85050.1 - 3.7e-08 33.1 9.1 6.5e-08 32.3 9.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 VDK85050.1 - 1.9e-06 27.7 3.3 1.9e-06 27.7 3.3 1.9 2 0 0 2 2 1 1 Zinc finger domain zf-C3HC4_2 PF13923.6 VDK85050.1 - 4.3e-06 26.5 12.3 4.3e-06 26.5 12.3 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 VDK85050.1 - 1.1e-05 25.1 1.9 1.1e-05 25.1 1.9 2.6 2 0 0 2 2 2 1 CCCH-type zinc finger zf-RING_5 PF14634.6 VDK85050.1 - 1.7e-05 24.7 14.0 3.1e-05 23.8 14.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 VDK85050.1 - 2.1e-05 24.3 13.2 4.4e-05 23.3 13.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK85050.1 - 9.9e-05 22.6 11.4 9.9e-05 22.6 11.4 1.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK85050.1 - 0.00034 20.6 11.3 0.00078 19.4 11.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_10 PF16685.5 VDK85050.1 - 0.00098 19.2 6.3 0.00098 19.2 6.3 1.7 2 0 0 2 2 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 VDK85050.1 - 0.0064 16.3 8.8 0.012 15.4 8.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 VDK85050.1 - 0.023 14.9 11.4 0.06 13.5 11.4 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 VDK85050.1 - 0.091 12.6 7.5 0.2 11.5 7.5 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-CCCH_2 PF14608.6 VDK85050.1 - 1.2 9.7 7.4 0.11 13.1 2.3 2.0 2 0 0 2 2 1 0 RNA-binding, Nab2-type zinc finger HAD_2 PF13419.6 VDK85051.1 - 1.7e-14 54.3 0.0 2.3e-14 53.9 0.0 1.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 VDK85051.1 - 7.2e-07 29.7 0.0 8.6e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 VDK85051.1 - 0.00012 22.1 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like STT3 PF02516.14 VDK85052.1 - 2.8e-139 465.2 46.4 1.3e-134 449.8 42.2 2.8 2 1 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit Polyketide_cyc PF03364.20 VDK85053.1 - 1.3e-19 70.7 0.1 1.6e-19 70.4 0.1 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport dsrm PF00035.26 VDK85054.1 - 2e-19 70.1 0.8 2e-09 38.0 0.2 3.3 3 0 0 3 3 3 2 Double-stranded RNA binding motif Dicer_dimer PF03368.14 VDK85054.1 - 0.00048 20.2 0.1 1.5 9.0 0.0 3.4 3 1 0 3 3 3 2 Dicer dimerisation domain DND1_DSRM PF14709.7 VDK85054.1 - 0.032 14.5 3.6 7.1 7.0 0.3 4.2 3 2 0 3 3 3 0 double strand RNA binding domain from DEAD END PROTEIN 1 FAA_hydro_N_2 PF18288.1 VDK85054.1 - 0.1 13.0 0.1 0.24 11.8 0.1 1.6 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 LPP20 PF02169.16 VDK85054.1 - 5.9 7.3 5.7 33 4.9 0.0 3.9 4 1 0 4 4 4 0 LPP20 lipoprotein COX14 PF14880.6 VDK85055.1 - 3.2e-08 33.3 0.0 4.2e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c assembly Sensor PF13796.6 VDK85055.1 - 0.11 12.6 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Putative sensor Pkinase PF00069.25 VDK85060.1 - 0.00091 18.7 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85060.1 - 0.018 14.3 0.0 0.029 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase SapB_2 PF03489.17 VDK85062.1 - 3.6e-11 43.0 6.9 0.00025 21.1 0.3 4.6 4 0 0 4 4 4 2 Saposin-like type B, region 2 SapB_1 PF05184.15 VDK85062.1 - 1.2e-06 28.4 21.0 0.0064 16.5 0.6 5.5 7 0 0 7 7 7 3 Saposin-like type B, region 1 PA28_alpha PF02251.18 VDK85062.1 - 0.013 15.5 3.7 0.68 10.0 0.0 3.4 4 0 0 4 4 4 0 Proteasome activator pa28 alpha subunit DUF445 PF04286.12 VDK85062.1 - 0.058 13.2 0.3 0.22 11.3 0.1 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF445) CP12 PF02672.15 VDK85062.1 - 0.31 11.8 7.4 0.33 11.7 0.1 3.8 4 1 1 5 5 5 0 CP12 domain DUF5332 PF17266.2 VDK85062.1 - 3.2 7.4 11.6 12 5.5 0.4 3.8 2 1 1 3 3 3 0 Family of unknown function (DUF5332) Synapsin_C PF02750.14 VDK85063.1 - 4.5e-50 170.0 0.0 6e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 VDK85063.1 - 2.3e-17 63.1 0.1 2.1e-15 56.9 0.0 2.7 2 0 0 2 2 2 1 Synapsin, N-terminal domain RimK PF08443.11 VDK85063.1 - 6.5e-06 25.9 0.0 1.1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp PF02222.22 VDK85063.1 - 0.0095 15.5 0.0 0.023 14.2 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain Dscam_C PF12355.8 VDK85063.1 - 1.2 10.2 6.3 0.11 13.5 0.9 2.0 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal Ank_5 PF13857.6 VDK85064.1 - 1.4e-08 34.8 0.3 0.00053 20.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK85064.1 - 3.1e-08 34.1 0.2 1.9e-07 31.6 0.2 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK85064.1 - 1.8e-06 28.3 0.1 0.00028 21.4 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK85064.1 - 6.1e-05 23.1 0.7 0.059 14.0 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 VDK85064.1 - 8.5e-05 22.8 1.0 0.003 17.9 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Cauli_VI PF01693.16 VDK85064.1 - 0.0081 16.5 0.2 0.0081 16.5 0.2 2.2 3 0 0 3 3 3 1 Caulimovirus viroplasmin Sulfotransfer_1 PF00685.27 VDK85071.1 - 1.1e-10 41.5 1.0 5.4e-09 35.9 0.1 2.1 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 VDK85071.1 - 0.00033 21.1 0.1 0.042 14.2 0.1 2.1 1 1 1 2 2 2 2 Sulfotransferase family efThoc1 PF11957.8 VDK85073.1 - 2.7e-105 352.9 15.4 3.8e-105 352.4 15.4 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Death PF00531.22 VDK85073.1 - 0.00025 21.1 0.2 0.00086 19.4 0.2 2.0 1 0 0 1 1 1 1 Death domain PIGA PF08288.12 VDK85074.1 - 1.6e-37 128.0 2.2 1.7e-37 127.9 0.7 1.9 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 VDK85074.1 - 8e-28 97.6 0.3 2.7e-27 95.8 0.3 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 VDK85074.1 - 7.6e-25 87.4 0.0 1.3e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 VDK85074.1 - 5.7e-22 78.6 0.0 1.1e-21 77.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 VDK85074.1 - 2.8e-11 44.1 0.0 5.7e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 VDK85074.1 - 0.0014 19.0 0.0 0.0022 18.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 VDK85074.1 - 0.032 14.3 0.1 0.063 13.3 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like MH1 PF03165.16 VDK85074.1 - 0.089 13.0 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 MH1 domain AhpC-TSA PF00578.21 VDK85075.1 - 0.14 12.0 0.3 0.38 10.7 0.3 1.8 1 0 0 1 1 1 0 AhpC/TSA family Spc7 PF08317.11 VDK85075.1 - 0.36 9.7 42.7 3.4 6.5 15.3 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein CEP63 PF17045.5 VDK85075.1 - 2.2 8.1 42.5 0.24 11.3 6.3 4.1 1 1 2 3 3 3 0 Centrosomal protein of 63 kDa AAA_13 PF13166.6 VDK85075.1 - 2.4 6.7 37.4 0.24 10.0 19.4 2.2 1 1 1 2 2 2 0 AAA domain JmjC PF02373.22 VDK85076.1 - 5.4e-29 100.9 2.2 1e-28 100.0 0.8 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase TPR_1 PF00515.28 VDK85076.1 - 1.2e-15 56.6 11.4 0.00015 21.4 0.0 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 VDK85076.1 - 3.1e-11 42.5 12.0 0.00035 20.5 0.1 6.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK85076.1 - 2.3e-10 40.6 4.3 0.0011 19.2 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK85076.1 - 1.1e-07 31.7 2.9 0.11 13.0 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK85076.1 - 8.8e-07 29.5 0.2 0.044 14.4 0.0 3.8 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 VDK85076.1 - 3.4e-05 23.7 6.5 3.9 7.9 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK85076.1 - 0.00012 22.6 0.2 0.64 11.0 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK85076.1 - 0.00072 20.0 1.2 0.49 10.9 0.4 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK85076.1 - 0.002 17.7 1.9 4.7 7.0 0.0 4.1 4 0 0 4 4 4 2 TPR repeat TPR_9 PF13371.6 VDK85076.1 - 0.032 14.4 0.2 0.12 12.5 0.2 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK85076.1 - 0.033 14.8 0.4 25 5.8 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK85076.1 - 0.13 12.4 3.3 69 3.8 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK85077.1 - 0.00031 20.4 0.4 0.054 13.3 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK85077.1 - 0.0012 18.8 1.7 0.024 14.8 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK85077.1 - 0.0028 17.7 2.0 0.14 12.4 0.3 3.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK85077.1 - 0.0096 16.2 0.0 0.39 11.0 0.0 1.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK85077.1 - 0.082 13.6 0.0 0.16 12.7 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 VDK85077.1 - 0.15 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 SHNi-TPR RhoGEF PF00621.20 VDK85078.1 - 5.2e-36 124.6 0.8 8.2e-36 123.9 0.8 1.2 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 VDK85078.1 - 0.014 15.9 0.2 0.034 14.7 0.2 1.6 1 0 0 1 1 1 0 PH domain V_ATPase_I_N PF18670.1 VDK85080.1 - 0.086 13.3 0.7 1.3 9.5 0.1 2.4 2 0 0 2 2 2 0 V-type ATPase subunit I, N-terminal domain Piwi PF02171.17 VDK85086.1 - 3.6e-64 216.9 1.8 5.8e-64 216.2 1.8 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 VDK85086.1 - 7e-14 51.8 1.1 4.1e-13 49.3 0.2 2.6 3 0 0 3 3 3 1 PAZ domain ArgoN PF16486.5 VDK85086.1 - 0.00036 21.2 0.0 0.0011 19.6 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoMid PF16487.5 VDK85086.1 - 0.054 13.8 0.1 0.25 11.6 0.1 2.2 1 0 0 1 1 1 0 Mid domain of argonaute Glyco_transf_7N PF13733.6 VDK85087.1 - 2.2e-57 192.5 0.0 3.6e-57 191.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 VDK85087.1 - 2.3e-29 100.9 0.8 5e-29 99.8 0.4 1.8 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase EF-hand_7 PF13499.6 VDK85089.1 - 1.5e-15 57.3 7.7 2.1e-12 47.3 3.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK85089.1 - 1.8e-11 42.7 4.7 9.5e-05 21.7 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 VDK85089.1 - 1.8e-08 33.7 5.4 0.00063 19.5 0.5 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 VDK85089.1 - 0.00037 20.3 8.4 0.0019 18.0 1.3 2.9 2 1 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 VDK85089.1 - 0.0016 18.7 0.3 0.003 17.8 0.3 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 VDK85089.1 - 0.038 13.5 0.8 1.3 8.6 0.0 3.0 2 0 0 2 2 2 0 EF hand DUF3349 PF11829.8 VDK85089.1 - 0.055 14.3 0.1 0.092 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) PMBR PF09373.10 VDK85089.1 - 0.062 13.5 0.1 4.2 7.7 0.0 3.4 3 0 0 3 3 3 0 Pseudomurein-binding repeat Band_7 PF01145.25 VDK85090.1 - 1.8e-28 99.7 1.3 1.8e-28 99.7 1.3 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 VDK85090.1 - 1.9e-24 85.5 1.0 1.9e-24 85.5 1.0 2.4 3 0 0 3 3 3 1 C-terminal region of band_7 Band_7_1 PF13421.6 VDK85090.1 - 0.03 14.0 0.2 0.067 12.9 0.2 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family Med2 PF11214.8 VDK85090.1 - 0.12 12.6 1.1 1.7 8.9 0.0 3.3 3 2 1 4 4 4 0 Mediator complex subunit 2 Myb_CC_LHEQLE PF14379.6 VDK85090.1 - 0.24 11.1 3.4 0.29 10.9 1.0 2.3 2 0 0 2 2 2 0 MYB-CC type transfactor, LHEQLE motif Flot PF15975.5 VDK85090.1 - 2.7 8.2 15.7 0.039 14.2 4.5 2.6 1 1 1 2 2 2 0 Flotillin PID PF00640.23 VDK85091.1 - 1.5e-14 54.2 0.0 2.1e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) SH2 PF00017.24 VDK85091.1 - 1.8e-14 53.6 0.0 3.6e-14 52.6 0.0 1.6 1 0 0 1 1 1 1 SH2 domain NDUF_B5 PF09781.9 VDK85099.1 - 1.5e-21 76.9 0.2 1.7e-21 76.6 0.2 1.0 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit Collagen_bind_2 PF12904.7 VDK85099.1 - 0.11 12.5 1.0 0.18 11.8 1.0 1.4 1 1 0 1 1 1 0 Putative collagen-binding domain of a collagenase BPL_LplA_LipB PF03099.19 VDK85100.1 - 4.4e-09 36.3 0.0 2.8e-08 33.7 0.0 2.3 1 1 1 2 2 2 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 VDK85100.1 - 1.7e-05 24.7 0.0 3.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain EFP_N PF08207.12 VDK85100.1 - 0.14 12.2 0.7 3 7.9 0.0 2.4 2 0 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain WD40 PF00400.32 VDK85101.1 - 1.2e-39 133.6 20.8 3.1e-07 31.0 0.1 10.3 10 0 0 10 10 10 7 WD domain, G-beta repeat Utp12 PF04003.12 VDK85101.1 - 2.9e-19 69.4 0.2 6e-19 68.3 0.2 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 VDK85101.1 - 2e-15 56.9 3.8 0.0042 17.3 0.0 7.4 5 2 4 9 9 9 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK85101.1 - 1.9e-06 27.4 0.2 0.17 11.2 0.0 4.5 3 1 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 VDK85101.1 - 0.0028 16.7 6.8 2.2 7.2 0.0 5.2 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ThiD2 PF17792.1 VDK85101.1 - 0.018 15.5 0.1 0.082 13.4 0.1 2.1 2 0 0 2 2 2 0 ThiD2 family BTB PF00651.31 VDK85102.1 - 8.1e-11 42.1 1.0 1.2e-07 31.9 0.2 2.9 2 1 0 2 2 2 2 BTB/POZ domain Prok-E2_C PF14459.6 VDK85102.1 - 0.11 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic E2 family C I-set PF07679.16 VDK85118.1 - 2.8e-65 216.4 0.0 1.2e-15 57.3 0.0 5.0 5 0 0 5 5 5 5 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK85118.1 - 1.8e-61 204.7 0.2 2.6e-16 60.0 0.2 5.1 5 0 0 5 5 5 5 Immunoglobulin domain Ig_2 PF13895.6 VDK85118.1 - 7.6e-44 147.9 0.0 2e-12 47.3 0.0 5.1 5 0 0 5 5 5 4 Immunoglobulin domain ig PF00047.25 VDK85118.1 - 2.2e-39 133.5 0.0 1.3e-10 41.3 0.0 5.3 5 0 0 5 5 5 5 Immunoglobulin domain V-set PF07686.17 VDK85118.1 - 1.4e-25 89.5 2.0 0.00068 19.8 0.0 8.4 6 3 0 6 6 6 5 Immunoglobulin V-set domain Ig_6 PF18452.1 VDK85118.1 - 4.2e-16 58.2 0.0 0.035 13.7 0.0 5.4 5 0 0 5 5 5 5 Immunoglobulin domain Ig_5 PF16681.5 VDK85118.1 - 1.4e-14 54.2 0.0 0.0017 18.7 0.0 5.4 5 0 0 5 5 5 4 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 VDK85118.1 - 1.1e-08 35.0 0.1 0.77 9.9 0.0 4.5 4 0 0 4 4 4 2 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 VDK85118.1 - 1.2e-08 35.1 0.0 1 9.7 0.0 5.1 5 0 0 5 5 5 3 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 VDK85118.1 - 5.2e-07 29.6 0.0 0.014 15.5 0.0 4.5 5 0 0 5 5 5 1 Izumo-like Immunoglobulin domain V-set_CD47 PF08204.11 VDK85118.1 - 0.00076 19.5 0.0 13 5.8 0.0 4.8 5 1 0 5 5 5 0 CD47 immunoglobulin-like domain Ig_C17orf99 PF17736.1 VDK85118.1 - 0.0012 18.8 0.0 0.07 13.2 0.0 3.2 4 0 0 4 4 4 1 C17orf99 Ig domain Receptor_2B4 PF11465.8 VDK85118.1 - 0.0012 19.0 0.0 8.9 6.6 0.0 4.2 4 0 0 4 4 4 1 Natural killer cell receptor 2B4 C1-set PF07654.15 VDK85118.1 - 0.012 16.0 0.1 2.8 8.4 0.0 3.8 4 1 0 4 4 4 0 Immunoglobulin C1-set domain BiPBP_C PF06832.12 VDK85118.1 - 0.11 12.6 0.0 19 5.4 0.0 2.9 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family Ribosomal_L7Ae PF01248.26 VDK85124.1 - 5.6e-12 45.2 0.1 1.5e-11 43.9 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Abhydrolase_2 PF02230.16 VDK85125.1 - 5.8e-75 251.8 0.0 6.4e-75 251.7 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 VDK85125.1 - 2.4e-06 27.0 0.5 0.0012 18.1 0.1 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.18 VDK85125.1 - 2.6e-06 27.2 0.0 4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 VDK85125.1 - 4.9e-06 27.3 0.0 5.4e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 VDK85125.1 - 0.00012 21.8 1.5 0.00062 19.5 1.5 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 VDK85125.1 - 0.017 15.0 0.0 0.034 14.0 0.0 1.4 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 VDK85125.1 - 0.031 13.8 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Lipase_3 PF01764.25 VDK85125.1 - 0.055 13.3 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 VDK85125.1 - 0.25 11.0 0.2 0.39 10.3 0.2 1.6 1 1 0 1 1 1 0 Putative esterase EMP70 PF02990.16 VDK85126.1 - 1.7e-156 522.0 0.5 1.7e-156 522.0 0.5 1.9 2 0 0 2 2 2 1 Endomembrane protein 70 CopD PF05425.13 VDK85126.1 - 0.8 10.1 12.7 0.052 14.0 5.4 2.4 2 0 0 2 2 2 0 Copper resistance protein D TM2 PF05154.16 VDK85127.1 - 0.0054 17.0 1.1 0.0054 17.0 1.1 2.8 3 0 0 3 3 3 1 TM2 domain DUF4064 PF13273.6 VDK85127.1 - 3.8 7.8 17.2 0.1 12.9 3.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) zf-H2C2_2 PF13465.6 VDK85133.1 - 2e-19 69.0 28.7 1.9e-08 34.4 0.7 4.6 5 0 0 5 5 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK85133.1 - 4.3e-15 55.1 19.4 0.00019 22.0 1.8 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK85133.1 - 4.1e-14 52.2 25.4 6.6e-05 23.1 1.7 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-met PF12874.7 VDK85133.1 - 9.5e-08 32.2 13.7 0.0015 18.9 1.3 3.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zinc_ribbon_9 PF14369.6 VDK85133.1 - 1.8e-07 31.3 8.6 0.008 16.4 0.2 3.3 3 0 0 3 3 3 3 zinc-ribbon zf-Di19 PF05605.12 VDK85133.1 - 8.4e-06 26.0 6.7 0.0017 18.6 2.9 2.5 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 VDK85133.1 - 3.8e-05 23.8 9.6 0.041 14.2 0.1 4.0 4 0 0 4 4 3 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 VDK85133.1 - 0.00019 20.9 10.7 0.47 10.1 0.1 3.6 4 0 0 4 4 3 3 Ubiquitin-Binding Zinc Finger Zn-ribbon_8 PF09723.10 VDK85133.1 - 0.00023 21.2 7.7 0.019 15.0 3.6 2.7 1 1 2 3 3 3 2 Zinc ribbon domain zf-C2H2_6 PF13912.6 VDK85133.1 - 0.00027 20.9 20.9 0.013 15.5 0.1 4.3 5 0 0 5 5 4 3 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 VDK85133.1 - 0.0003 20.6 10.6 0.04 13.8 6.0 3.3 2 1 1 3 3 3 1 SprT-like zinc ribbon domain zf-LYAR PF08790.11 VDK85133.1 - 0.00069 19.5 3.2 1.1 9.2 0.1 3.4 3 0 0 3 3 3 1 LYAR-type C2HC zinc finger zf-HIT PF04438.16 VDK85133.1 - 0.0016 18.3 13.4 1.4 8.8 1.7 3.5 3 0 0 3 3 3 2 HIT zinc finger C1_2 PF03107.16 VDK85133.1 - 0.0044 17.3 6.6 5.2 7.5 0.1 3.4 3 0 0 3 3 3 0 C1 domain C1_4 PF07975.12 VDK85133.1 - 0.013 15.7 10.1 6.5 7.1 5.4 3.4 1 1 2 3 3 3 0 TFIIH C1-like domain zf-C2H2_9 PF16293.5 VDK85133.1 - 0.014 15.2 6.6 6 6.8 0.0 3.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (1 copy) PHD PF00628.29 VDK85133.1 - 0.019 14.8 4.4 6.5 6.7 0.1 3.3 3 0 0 3 3 3 0 PHD-finger zf-4CXXC_R1 PF10497.9 VDK85133.1 - 0.026 14.7 8.9 2.1 8.6 0.3 3.2 1 1 2 3 3 3 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C2H2_2 PF12756.7 VDK85133.1 - 0.027 14.8 10.9 6.3 7.2 0.1 3.5 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) HCMV_UL139 PF12507.8 VDK85133.1 - 0.034 14.5 0.2 0.043 14.2 0.2 1.3 1 0 0 1 1 1 0 Human Cytomegalovirus UL139 protein zf-C2H2_11 PF16622.5 VDK85133.1 - 0.034 13.9 2.3 0.034 13.9 2.3 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type ADK_lid PF05191.14 VDK85133.1 - 0.041 13.9 8.7 0.35 10.9 1.8 3.3 2 1 1 3 3 3 0 Adenylate kinase, active site lid zinc-ribbons_6 PF07191.12 VDK85133.1 - 0.073 13.1 9.5 4.8 7.2 7.5 3.0 2 1 0 2 2 1 0 zinc-ribbons HypA PF01155.19 VDK85133.1 - 0.081 12.9 5.1 0.26 11.3 1.2 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-Dof PF02701.15 VDK85133.1 - 0.094 12.9 12.4 2.7 8.2 0.2 2.9 1 1 1 2 2 2 0 Dof domain, zinc finger TerY_C PF15616.6 VDK85133.1 - 0.14 12.3 3.5 0.19 11.8 0.6 2.2 1 1 1 2 2 2 0 TerY-C metal binding domain Zn_Tnp_IS1595 PF12760.7 VDK85133.1 - 0.15 12.0 12.1 0.23 11.5 2.1 2.6 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-Sec23_Sec24 PF04810.15 VDK85133.1 - 0.18 11.8 11.3 0.32 11.1 0.5 3.2 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-HYPF PF07503.12 VDK85133.1 - 0.2 11.5 7.0 0.72 9.7 0.6 3.2 3 0 0 3 3 3 0 HypF finger TF_Zn_Ribbon PF08271.12 VDK85133.1 - 0.24 11.0 10.8 11 5.6 0.1 3.4 3 0 0 3 3 3 0 TFIIB zinc-binding XPA_N PF01286.18 VDK85133.1 - 0.38 10.8 7.0 6.2 6.9 0.1 3.4 3 0 0 3 3 3 0 XPA protein N-terminal Zn_Tnp_IS91 PF14319.6 VDK85133.1 - 0.47 10.5 11.1 1.4e+02 2.6 11.1 3.1 1 1 0 1 1 1 0 Transposase zinc-binding domain Zn_ribbon_recom PF13408.6 VDK85133.1 - 0.56 10.8 9.8 11 6.6 6.3 2.8 2 1 1 3 3 2 0 Recombinase zinc beta ribbon domain zf-H2C2_5 PF13909.6 VDK85133.1 - 0.58 10.0 33.3 1.5 8.6 2.9 6.0 4 3 0 4 4 4 0 C2H2-type zinc-finger domain zf_C2H2_ZHX PF18387.1 VDK85133.1 - 0.6 9.8 5.8 2.9 7.6 0.0 3.1 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain GAGA PF09237.11 VDK85133.1 - 0.68 9.8 6.9 2 8.3 0.1 3.3 1 1 2 3 3 3 0 GAGA factor Nudix_N_2 PF14803.6 VDK85133.1 - 0.77 9.7 10.7 2.1 8.3 3.3 3.2 2 1 1 3 3 3 0 Nudix N-terminal DUF629 PF04780.12 VDK85133.1 - 0.93 7.9 7.3 5.7 5.3 2.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf_C2H2_10 PF18414.1 VDK85133.1 - 1.1 8.8 11.9 4.2 7.0 0.0 3.7 3 1 0 3 3 3 0 C2H2 type zinc-finger zf-RING_7 PF02591.15 VDK85133.1 - 1.7 8.9 9.4 12 6.1 0.2 3.7 4 0 0 4 4 3 0 C4-type zinc ribbon domain A2L_zn_ribbon PF08792.10 VDK85133.1 - 1.9 8.3 7.4 46 3.9 0.1 3.3 3 0 0 3 3 3 0 A2L zinc ribbon domain FYDLN_acid PF09538.10 VDK85133.1 - 2.6 8.8 9.1 62 4.3 0.4 3.5 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-TFIIB PF13453.6 VDK85133.1 - 3.1 7.2 8.6 8.7 5.8 2.9 3.2 2 1 1 3 3 3 0 Transcription factor zinc-finger zinc_ribbon_15 PF17032.5 VDK85133.1 - 3.2 8.6 9.6 1.6 9.5 2.0 2.6 1 1 2 3 3 3 0 zinc-ribbon family ARS2 PF04959.13 VDK85133.1 - 3.6 7.9 6.8 2 8.7 0.3 2.8 2 2 1 3 3 3 0 Arsenite-resistance protein 2 zinc_ribbon_4 PF13717.6 VDK85133.1 - 3.7 7.6 14.7 10 6.2 0.9 3.4 3 0 0 3 3 3 0 zinc-ribbon domain zf-UDP PF14569.6 VDK85133.1 - 3.7 7.7 10.8 34 4.6 0.1 3.1 1 1 2 3 3 3 0 Zinc-binding RING-finger DNA_RNApol_7kD PF03604.13 VDK85133.1 - 3.8 7.3 8.1 22 4.8 0.4 3.6 4 0 0 4 4 3 0 DNA directed RNA polymerase, 7 kDa subunit Opy2 PF09463.10 VDK85133.1 - 3.9 7.9 11.1 24 5.4 0.1 3.5 4 0 0 4 4 3 0 Opy2 protein TFIIS_C PF01096.18 VDK85133.1 - 4.2 7.3 10.0 26 4.8 0.4 3.5 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) zinc_ribbon_10 PF10058.9 VDK85133.1 - 4.3 7.2 11.0 46 3.9 6.9 3.0 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zinc_ribbon_5 PF13719.6 VDK85133.1 - 4.6 7.1 8.0 49 3.8 0.4 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Rep_fac-A_C PF08646.10 VDK85133.1 - 4.9 6.9 7.2 20 4.9 3.0 2.9 1 1 1 2 2 2 0 Replication factor-A C terminal domain PhnA_Zn_Ribbon PF08274.12 VDK85133.1 - 6 6.9 10.8 4.5 7.3 3.2 3.2 3 1 0 3 3 2 0 PhnA Zinc-Ribbon IBR PF01485.21 VDK85133.1 - 7.9 6.8 12.9 25 5.2 0.5 3.2 1 1 2 3 3 3 0 IBR domain, a half RING-finger domain Secretogranin_V PF05281.11 VDK85135.1 - 5.1e-38 130.9 0.1 6.9e-38 130.5 0.1 1.1 1 0 0 1 1 1 1 Neuroendocrine protein 7B2 precursor (Secretogranin V) PI3_PI4_kinase PF00454.27 VDK85137.1 - 5.9e-31 108.2 0.0 8.2e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase CTP_synth_N PF06418.14 VDK85138.1 - 1.2e-117 392.0 0.1 1.6e-117 391.5 0.1 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 VDK85138.1 - 1.4e-45 155.4 1.9 2.3e-37 128.6 0.2 2.4 1 1 1 2 2 2 2 Glutamine amidotransferase class-I MRP-S34 PF16053.5 VDK85138.1 - 1.3e-37 128.3 0.1 2.6e-37 127.4 0.1 1.5 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 Peptidase_C26 PF07722.13 VDK85138.1 - 0.00027 20.8 1.1 0.48 10.1 0.2 2.6 2 0 0 2 2 2 2 Peptidase C26 CbiA PF01656.23 VDK85138.1 - 0.00035 20.6 0.0 0.00063 19.8 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 VDK85138.1 - 0.03 13.3 0.2 0.065 12.2 0.2 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ArsA_ATPase PF02374.15 VDK85138.1 - 0.087 12.0 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Anion-transporting ATPase DAGK_cat PF00781.24 VDK85140.1 - 5.1e-24 84.3 0.0 8.7e-24 83.5 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Tim54 PF11711.8 VDK85140.1 - 0.13 11.0 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Band_7 PF01145.25 VDK85142.1 - 2.3e-31 109.2 0.5 3e-31 108.8 0.5 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 VDK85142.1 - 0.0043 16.8 0.2 0.0067 16.2 0.2 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family GP68 PF17469.2 VDK85142.1 - 0.15 12.5 0.1 0.31 11.5 0.1 1.5 1 0 0 1 1 1 0 Phage protein Gp68 Requiem_N PF14051.6 VDK85144.1 - 6.6e-26 90.3 1.3 1.4e-25 89.3 1.3 1.6 1 0 0 1 1 1 1 N-terminal domain of DPF2/REQ. PHD PF00628.29 VDK85144.1 - 1.5e-20 72.8 24.3 4.6e-13 48.9 4.3 3.2 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.6 VDK85144.1 - 0.0048 16.4 0.5 0.0048 16.4 0.5 4.2 4 1 1 5 5 5 2 PHD-finger zf-C2H2_11 PF16622.5 VDK85144.1 - 0.025 14.4 0.2 0.025 14.4 0.2 4.1 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 VDK85144.1 - 0.082 13.8 1.0 0.082 13.8 1.0 6.2 6 1 1 7 7 7 0 C2H2-type zinc finger zf-PHD-like PF15446.6 VDK85144.1 - 0.092 12.4 10.7 0.8 9.3 1.1 2.9 1 1 1 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 VDK85144.1 - 0.65 9.9 29.5 0.059 13.3 3.8 5.0 2 1 3 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 VDK85144.1 - 4.9 7.3 22.7 8.7 6.5 5.2 4.1 1 1 1 2 2 2 0 KIAA1045 RING finger zf-RING_2 PF13639.6 VDK85144.1 - 6.9 7.1 22.8 5.2 7.5 8.5 3.4 2 1 2 4 4 4 0 Ring finger domain PHD_4 PF16866.5 VDK85144.1 - 7.5 6.7 25.7 0.032 14.3 10.6 3.6 3 1 1 4 4 4 0 PHD-finger SURF1 PF02104.15 VDK85146.1 - 1e-37 130.1 0.0 1.3e-37 129.8 0.0 1.1 1 0 0 1 1 1 1 SURF1 family HSP20 PF00011.21 VDK85148.1 - 1e-11 44.8 0.1 1.4e-11 44.4 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK85148.1 - 0.11 12.0 0.1 0.44 10.1 0.0 1.9 2 0 0 2 2 2 0 HSP20-like domain found in ArsA STAR_dimer PF16544.5 VDK85152.1 - 3.6e-07 29.7 0.2 8.7e-07 28.4 0.2 1.6 1 0 0 1 1 1 1 Homodimerisation region of STAR domain protein KH_1 PF00013.29 VDK85152.1 - 1.7e-05 24.6 0.0 3.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 KH domain Peptidase_C2 PF00648.21 VDK85153.1 - 8.1e-73 245.0 0.0 1.1e-72 244.6 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease DZR PF12773.7 VDK85153.1 - 0.12 12.4 1.1 0.3 11.1 1.1 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-RanBP PF00641.18 VDK85153.1 - 0.16 11.3 4.2 0.35 10.2 4.2 1.6 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zinc_ribbon_2 PF13240.6 VDK85153.1 - 0.41 10.4 2.3 0.91 9.3 2.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Myb_DNA-binding PF00249.31 VDK85154.1 - 1.1e-11 44.7 5.6 5.6e-07 29.7 0.0 3.3 4 0 0 4 4 4 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 VDK85154.1 - 4.5e-11 42.5 8.3 1.2e-06 28.3 0.9 2.5 2 0 0 2 2 2 2 Myb DNA-binding like ELM2 PF01448.24 VDK85154.1 - 3.7e-05 24.4 0.2 0.0001 23.0 0.2 1.8 1 0 0 1 1 1 1 ELM2 domain GATA PF00320.27 VDK85154.1 - 0.0033 17.0 2.8 0.0079 15.8 2.8 1.7 1 0 0 1 1 1 1 GATA zinc finger FAM60A PF15396.6 VDK85154.1 - 0.091 12.7 4.8 0.048 13.7 1.5 2.2 2 0 0 2 2 2 0 Protein Family FAM60A UBA_4 PF14555.6 VDK85154.1 - 0.1 12.5 0.8 1 9.2 0.1 2.7 2 0 0 2 2 2 0 UBA-like domain zinc_ribbon_9 PF14369.6 VDK85154.1 - 0.11 12.8 0.8 0.4 11.0 0.8 2.0 1 0 0 1 1 1 0 zinc-ribbon Myb_DNA-bind_6 PF13921.6 VDK85154.1 - 0.24 11.7 4.1 12 6.3 0.2 3.9 4 0 0 4 4 4 0 Myb-like DNA-binding domain Hydrolase_3 PF08282.12 VDK85154.1 - 0.84 9.3 5.6 0.29 10.8 2.5 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase KASH PF10541.9 VDK85156.1 - 0.037 14.3 0.4 0.057 13.7 0.4 1.4 1 0 0 1 1 1 0 Nuclear envelope localisation domain PP2C PF00481.21 VDK85157.1 - 3.5e-75 253.0 0.0 4.6e-75 252.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_C PF07830.13 VDK85157.1 - 3.7e-23 81.8 0.0 9e-23 80.5 0.0 1.7 1 0 0 1 1 1 1 Protein serine/threonine phosphatase 2C, C-terminal domain PP2C_2 PF13672.6 VDK85157.1 - 2.3e-07 30.7 0.1 6.5e-07 29.2 0.1 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C EnY2 PF10163.9 VDK85157.1 - 0.011 16.1 0.1 0.039 14.3 0.1 1.9 2 0 0 2 2 2 0 Transcription factor e(y)2 Nucleolin_bd PF16725.5 VDK85157.1 - 0.11 12.1 0.0 0.33 10.7 0.0 1.7 1 0 0 1 1 1 0 Nucleolin binding domain Sec66 PF09802.9 VDK85157.1 - 0.15 11.6 0.1 0.26 10.9 0.1 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Pkinase PF00069.25 VDK85160.1 - 3e-43 148.1 0.0 4.6e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85160.1 - 2.9e-28 98.9 0.0 4.6e-28 98.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase MFS_1 PF07690.16 VDK85161.1 - 2.1e-16 59.8 20.0 2.1e-16 59.8 20.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Annexin PF00191.20 VDK85162.1 - 2.9e-25 88.1 1.3 3.8e-09 36.5 0.1 4.1 4 1 0 4 4 4 3 Annexin Pkinase PF00069.25 VDK85163.1 - 1.9e-05 24.2 0.1 2.2e-05 23.9 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Clat_adaptor_s PF01217.20 VDK85165.1 - 1.4e-53 180.6 2.5 1.8e-53 180.3 2.5 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribosomal_L39 PF00832.20 VDK85166.1 - 5.1e-22 77.2 14.3 6.4e-22 76.9 14.3 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein CS PF04969.16 VDK85167.1 - 1.4e-17 64.4 0.7 3.1e-17 63.4 0.7 1.6 1 0 0 1 1 1 1 CS domain Nudc_N PF14050.6 VDK85167.1 - 3.2e-11 43.1 0.1 1.5e-10 40.9 0.0 2.2 2 1 0 2 2 2 1 N-terminal conserved domain of Nudc. Hid1 PF12722.7 VDK85167.1 - 1.3 7.1 7.4 2.1 6.3 7.4 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ank_5 PF13857.6 VDK85169.1 - 3.9e-14 52.5 0.6 7.7e-08 32.5 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 VDK85169.1 - 4.6e-13 49.4 0.2 0.0058 17.2 0.0 5.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK85169.1 - 8.6e-13 48.7 1.8 0.0019 18.7 0.0 5.6 5 1 0 6 6 6 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDK85169.1 - 4.8e-12 44.9 0.7 0.0011 19.3 0.0 5.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 VDK85169.1 - 1.5e-08 34.7 0.2 0.0037 17.6 0.0 3.4 2 0 0 2 2 2 2 Ankyrin repeat TPR_8 PF13181.6 VDK85169.1 - 3.9e-06 26.6 2.3 0.014 15.6 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK85169.1 - 1.9e-05 24.2 0.3 0.12 12.2 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK85169.1 - 3.9e-05 23.4 0.5 0.18 12.0 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat LRR_4 PF12799.7 VDK85169.1 - 0.00016 22.0 24.8 0.14 12.6 5.1 5.2 3 1 0 4 4 4 2 Leucine Rich repeats (2 copies) TPR_12 PF13424.6 VDK85169.1 - 0.00017 21.8 5.2 0.27 11.5 0.0 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat RPN7 PF10602.9 VDK85169.1 - 0.49 10.1 16.9 0.76 9.5 0.3 4.7 5 0 0 5 5 5 0 26S proteasome subunit RPN7 AAT PF03417.16 VDK85169.1 - 1.6 8.4 4.1 0.39 10.4 0.2 1.9 2 0 0 2 2 2 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase LRR_6 PF13516.6 VDK85169.1 - 2 8.6 24.5 0.051 13.7 0.5 6.4 8 0 0 8 8 5 0 Leucine Rich repeat LRR_8 PF13855.6 VDK85169.1 - 3.9 7.3 22.8 9.3 6.1 2.0 4.8 2 2 3 5 5 5 0 Leucine rich repeat HSBP1 PF06825.12 VDK85170.1 - 2.1e-24 85.1 5.1 3.6e-24 84.4 5.1 1.4 1 0 0 1 1 1 1 Heat shock factor binding protein 1 KH_6 PF15985.5 VDK85170.1 - 1.4e-12 47.7 0.3 2.8e-12 46.8 0.3 1.4 1 0 0 1 1 1 1 KH domain EspB PF05802.11 VDK85170.1 - 0.017 15.1 3.5 0.028 14.4 3.5 1.3 1 0 0 1 1 1 0 Enterobacterial EspB protein CLZ PF16526.5 VDK85170.1 - 0.051 13.9 1.6 0.077 13.4 1.4 1.5 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TrbI PF03743.14 VDK85170.1 - 0.2 11.5 0.8 0.38 10.6 0.5 1.5 2 0 0 2 2 2 0 Bacterial conjugation TrbI-like protein DUF883 PF05957.13 VDK85170.1 - 0.23 12.1 0.6 0.48 11.1 0.6 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) UPF0242 PF06785.11 VDK85170.1 - 0.57 10.3 4.3 0.84 9.7 4.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TLD PF07534.16 VDK85172.1 - 4.8e-29 101.4 0.9 8.6e-29 100.5 0.9 1.4 1 0 0 1 1 1 1 TLD Complex1_30kDa PF00329.19 VDK85173.1 - 1.3e-39 135.6 0.0 2e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2087 PF09860.9 VDK85173.1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) Myb_DNA-binding PF00249.31 VDK85178.1 - 7.6e-15 54.8 0.4 1.9e-06 28.0 0.0 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 VDK85178.1 - 1.2e-08 35.1 2.8 0.00038 20.6 0.6 3.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain YlzJ PF14035.6 VDK85178.1 - 5.1 7.4 9.9 10 6.4 6.6 3.3 2 0 0 2 2 2 0 YlzJ-like protein Glyco_hydro_38C PF07748.13 VDK85179.1 - 8.4e-18 65.2 0.2 1.6e-17 64.3 0.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 VDK85179.1 - 2.5e-13 50.0 0.0 6.2e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38N PF01074.22 VDK85179.1 - 9.9e-11 41.5 0.1 1.5e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain EF-hand_7 PF13499.6 VDK85179.1 - 0.0019 18.6 0.3 0.006 17.0 0.3 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK85179.1 - 0.093 12.7 0.1 0.61 10.2 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 VDK85179.1 - 0.11 12.1 0.1 7.3 6.4 0.0 2.6 2 0 0 2 2 2 0 EF hand SNF2_N PF00176.23 VDK85188.1 - 3.3e-62 210.2 0.0 5.9e-61 206.1 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain ResIII PF04851.15 VDK85188.1 - 6.2e-07 29.6 0.0 2.1e-06 27.8 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 VDK85188.1 - 0.00055 19.8 0.0 0.01 15.6 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase FtsJ PF01728.19 VDK85189.1 - 2.4e-30 105.9 0.0 4.6e-30 105.0 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 VDK85189.1 - 7.3e-09 35.4 1.6 1.9e-08 34.1 1.6 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 VDK85189.1 - 0.00011 22.3 0.3 0.00025 21.1 0.3 1.6 1 0 0 1 1 1 1 G-patch domain KH_9 PF17904.1 VDK85192.1 - 6e-32 109.9 1.0 1.1e-30 105.8 0.5 2.4 2 0 0 2 2 2 1 FMRP KH0 domain KH_1 PF00013.29 VDK85192.1 - 2e-17 62.7 0.2 3.7e-10 39.5 0.2 3.2 4 0 0 4 4 4 2 KH domain Tudor_FRX1 PF18336.1 VDK85192.1 - 2.1e-11 43.6 0.0 6.7e-11 41.9 0.0 1.9 1 0 0 1 1 1 1 Fragile X mental retardation Tudor domain FXMRP1_C_core PF12235.8 VDK85192.1 - 2.9e-05 24.7 17.5 9.7e-05 23.0 17.5 1.8 1 1 0 1 1 1 1 Fragile X-related 1 protein core C terminal DUF4537 PF15057.6 VDK85192.1 - 0.0094 16.0 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Asp1 PF16993.5 VDK85192.1 - 0.01 15.1 0.3 0.014 14.6 0.3 1.1 1 0 0 1 1 1 0 Accessory Sec system protein Asp1 KH_4 PF13083.6 VDK85192.1 - 0.019 14.8 1.2 0.59 10.0 0.4 3.2 2 1 1 3 3 3 0 KH domain KH_2 PF07650.17 VDK85192.1 - 0.085 12.7 0.5 23 4.9 0.5 2.7 2 0 0 2 2 2 0 KH domain Tudor_2 PF18104.1 VDK85192.1 - 0.38 10.5 1.6 0.41 10.4 0.0 1.9 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain SYF2 PF08231.12 VDK85193.1 - 1e-42 146.3 9.1 1e-42 146.3 9.1 1.7 2 0 0 2 2 2 1 SYF2 splicing factor Ank_4 PF13637.6 VDK85197.1 - 5.9e-39 132.0 4.1 4e-11 43.2 0.0 5.1 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK85197.1 - 1.1e-37 128.4 0.8 2.3e-14 53.7 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK85197.1 - 5.2e-31 106.3 3.1 1.6e-09 37.8 0.2 5.8 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK85197.1 - 7.2e-29 96.6 0.8 4.8e-06 26.5 0.0 5.9 5 0 0 5 5 5 5 Ankyrin repeat Ank PF00023.30 VDK85197.1 - 1.6e-28 97.9 3.6 2.2e-07 31.0 0.1 5.9 5 0 0 5 5 5 5 Ankyrin repeat COX17 PF05051.13 VDK85197.1 - 9.2e-20 70.7 7.5 9.2e-20 70.7 7.5 2.0 2 0 0 2 2 2 1 Cytochrome C oxidase copper chaperone (COX17) Sec20 PF03908.13 VDK85197.1 - 1.1e-13 50.9 1.3 1.1e-13 50.9 1.3 2.8 2 1 0 2 2 2 1 Sec20 DUF2207 PF09972.9 VDK85197.1 - 8 5.1 6.9 2 7.1 0.4 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) UQ_con PF00179.26 VDK85198.1 - 4.2e-44 149.6 0.0 5.9e-44 149.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 VDK85198.1 - 0.00015 21.5 0.0 0.00029 20.5 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 VDK85198.1 - 0.0068 16.7 0.2 0.013 15.8 0.1 1.6 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 VDK85198.1 - 0.028 14.3 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 UEV domain UBA PF00627.31 VDK85198.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 UBA/TS-N domain ApoC-I PF04691.12 VDK85199.1 - 0.064 13.2 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) CBM60 PF16841.5 VDK85199.1 - 0.077 13.4 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 Ca-dependent carbohydrate-binding module xylan-binding Dpy19 PF10034.9 VDK85202.1 - 4.1e-155 517.6 25.6 1.7e-89 300.8 5.8 2.1 1 1 1 2 2 2 2 Q-cell neuroblast polarisation HPIH PF13323.6 VDK85202.1 - 0.11 12.3 0.0 0.59 10.0 0.0 1.9 2 0 0 2 2 2 0 N-terminal domain with HPIH motif DUF4500 PF14937.6 VDK85202.1 - 0.22 11.6 0.7 0.58 10.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) Y_phosphatase PF00102.27 VDK85206.1 - 1e-35 123.5 0.4 1.7e-35 122.7 0.4 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CPG4 PF15481.6 VDK85207.1 - 0.034 14.8 4.1 0.034 14.8 4.1 2.0 2 1 0 2 2 2 0 Chondroitin proteoglycan 4 Y_phosphatase PF00102.27 VDK85209.1 - 7.8e-51 172.9 0.7 7.4e-39 133.7 1.6 2.2 2 0 0 2 2 2 2 Protein-tyrosine phosphatase Rhabdo_M1 PF03342.13 VDK85209.1 - 0.072 12.4 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) Pkinase_C PF00433.24 VDK85213.1 - 2e-11 44.4 2.0 2.4e-11 44.2 2.0 1.1 1 0 0 1 1 1 1 Protein kinase C terminal domain PAN_1 PF00024.26 VDK85214.1 - 4.7e-07 29.7 9.8 1.8e-05 24.6 1.6 2.9 2 0 0 2 2 2 2 PAN domain Sec20 PF03908.13 VDK85215.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.4 1 1 0 1 1 1 0 Sec20 An_peroxidase PF03098.15 VDK85217.1 - 1e-189 631.6 0.0 1.3e-189 631.3 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase T-box PF00907.22 VDK85226.1 - 1.7e-07 31.7 0.0 2.3e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 T-box DUF384 PF04064.13 VDK85228.1 - 1e-07 31.7 0.0 1.1e-06 28.4 0.0 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF384) DUF383 PF04063.14 VDK85230.1 - 5.6e-19 68.5 0.7 9e-19 67.9 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF383) Mo25 PF08569.11 VDK85230.1 - 0.0039 16.6 0.6 0.3 10.4 0.0 2.1 1 1 1 2 2 2 2 Mo25-like DUF5463 PF17551.2 VDK85232.1 - 2.9 7.9 6.4 6.4 6.8 6.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5463) Trehalase PF01204.18 VDK85233.1 - 1.1e-162 542.4 0.0 1.4e-162 542.2 0.0 1.1 1 0 0 1 1 1 1 Trehalase GDE_C PF06202.14 VDK85233.1 - 1.7e-05 23.9 0.1 7.4e-05 21.9 0.1 1.9 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Glyco_hydro_63 PF03200.16 VDK85233.1 - 0.01 14.6 0.0 0.018 13.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain DUF832 PF05734.11 VDK85233.1 - 0.083 12.4 0.2 0.15 11.5 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus protein of unknown function (DUF832) Mucin PF01456.17 VDK85233.1 - 1.5 8.8 19.3 2.2 8.2 19.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein His_Phos_1 PF00300.22 VDK85239.1 - 5e-10 39.4 0.0 8.7e-10 38.6 0.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF4384 PF14326.6 VDK85239.1 - 0.035 14.2 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) Mei5 PF10376.9 VDK85241.1 - 0.35 10.7 6.1 0.7 9.7 6.1 1.5 1 1 0 1 1 1 0 Double-strand recombination repair protein Josephin PF02099.17 VDK85242.1 - 3e-45 154.3 0.0 8.1e-45 152.9 0.0 1.7 1 0 0 1 1 1 1 Josephin UIM PF02809.20 VDK85242.1 - 0.00061 19.5 13.0 0.00078 19.2 0.2 3.6 4 0 0 4 4 4 2 Ubiquitin interaction motif DUF4902 PF16245.5 VDK85242.1 - 0.06 13.2 0.3 4.1 7.3 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4902) Foamy_BEL PF03274.14 VDK85242.1 - 0.17 11.2 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 Foamy virus BEL 1/2 protein Sds3 PF08598.11 VDK85252.1 - 0.00072 19.6 13.8 0.00072 19.6 13.8 1.6 2 0 0 2 2 2 1 Sds3-like 2H-phosphodiest PF08975.10 VDK85252.1 - 0.16 11.9 0.5 0.57 10.2 0.2 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1868) SprA-related PF12118.8 VDK85252.1 - 0.28 10.3 4.6 0.43 9.7 4.6 1.2 1 0 0 1 1 1 0 SprA-related family KNOX2 PF03791.13 VDK85252.1 - 0.34 10.4 3.1 4.1 7.0 0.1 2.8 2 1 1 3 3 2 0 KNOX2 domain CFAP91 PF14738.6 VDK85252.1 - 0.6 10.1 21.0 0.049 13.7 15.5 1.9 1 1 1 2 2 2 0 Cilia- and flagella-associated protein 91 RNase_H_2 PF13482.6 VDK85253.1 - 0.032 14.2 0.1 0.41 10.6 0.1 2.4 2 0 0 2 2 2 0 RNase_H superfamily 2-oxoacid_dh PF00198.23 VDK85254.1 - 4.7e-66 222.6 2.2 4.7e-65 219.3 2.2 2.0 1 1 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 VDK85254.1 - 3.1e-18 65.4 0.0 5.6e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 VDK85254.1 - 6.9e-06 25.8 0.1 9.2e-05 22.2 0.0 2.4 1 1 1 2 2 2 1 Biotin-lipoyl like GCV_H PF01597.19 VDK85254.1 - 0.00046 20.1 0.0 0.00089 19.2 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage H-protein HlyD_D23 PF16576.5 VDK85254.1 - 0.0064 15.7 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion RnfC_N PF13375.6 VDK85254.1 - 0.13 12.3 0.0 4.3 7.3 0.0 2.3 1 1 1 2 2 2 0 RnfC Barrel sandwich hybrid domain adh_short PF00106.25 VDK85255.1 - 1.8e-24 86.3 0.0 1.1e-16 60.8 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 VDK85255.1 - 5.7e-16 58.8 0.0 3.8e-10 39.7 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK85255.1 - 3.9e-06 26.9 0.0 7.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 VDK85255.1 - 0.0014 18.2 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 VDK85255.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 VDK85255.1 - 0.15 11.4 0.0 0.32 10.4 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain EMP24_GP25L PF01105.24 VDK85256.1 - 1e-53 182.0 0.2 1.2e-53 181.8 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF2960 PF11173.8 VDK85256.1 - 0.12 12.9 0.7 0.2 12.1 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2960) Glycos_transf_2 PF00535.26 VDK85257.1 - 7.5e-24 84.4 0.0 1.2e-23 83.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ricin_B_lectin PF00652.22 VDK85257.1 - 3.7e-13 49.9 0.4 6.1e-13 49.1 0.4 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 VDK85257.1 - 9.6e-07 28.4 0.0 2.3e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase Glyco_tranf_2_2 PF10111.9 VDK85257.1 - 0.00018 21.1 0.0 0.00069 19.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 MH2 PF03166.14 VDK85260.1 - 5.5e-61 206.0 0.0 1.1e-60 205.1 0.0 1.5 1 0 0 1 1 1 1 MH2 domain IRF-3 PF10401.9 VDK85260.1 - 0.037 13.8 0.0 0.089 12.6 0.0 1.6 1 1 0 1 1 1 0 Interferon-regulatory factor 3 Collagen PF01391.18 VDK85261.1 - 4.3e-23 80.8 120.8 5.4e-10 38.9 34.8 4.2 3 2 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK85261.1 - 1.6e-19 69.7 0.1 2e-19 69.3 0.1 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain COX14 PF14880.6 VDK85261.1 - 0.0064 16.3 2.7 0.0099 15.7 2.7 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c assembly PT PF04886.12 VDK85262.1 - 0.0075 15.8 0.1 0.013 15.0 0.1 1.4 1 0 0 1 1 1 1 PT repeat Collagen PF01391.18 VDK85263.1 - 8.9e-07 28.6 15.9 0.0011 18.6 9.2 2.6 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) MIP-T3 PF10243.9 VDK85264.1 - 7.4e-31 106.5 0.6 7.4e-31 106.5 0.6 2.1 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 CH-like domain MIP-T3_C PF17749.1 VDK85264.1 - 3.2e-24 85.6 12.9 3.2e-24 85.6 12.9 2.5 2 1 0 2 2 2 1 Microtubule-binding protein MIP-T3 C-terminal region DUF2992 PF11208.8 VDK85264.1 - 0.011 15.9 7.1 0.011 15.9 7.1 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF2992) SpecificRecomb PF10136.9 VDK85264.1 - 0.11 10.8 5.1 0.15 10.4 5.1 1.2 1 0 0 1 1 1 0 Site-specific recombinase XhlA PF10779.9 VDK85264.1 - 6 7.2 10.8 16 5.8 0.4 3.6 1 1 0 2 2 2 0 Haemolysin XhlA Synaptobrevin PF00957.21 VDK85264.1 - 8.1 6.3 8.2 1.1 9.1 2.2 2.6 2 1 0 2 2 2 0 Synaptobrevin Pkinase_C PF00433.24 VDK85265.1 - 0.15 12.7 0.3 0.5 11.1 0.0 2.1 2 0 0 2 2 2 0 Protein kinase C terminal domain DB PF01682.19 VDK85267.1 - 2.9e-15 56.4 9.8 3.6e-15 56.1 9.8 1.1 1 0 0 1 1 1 1 DB module TGase_elicitor PF16683.5 VDK85267.1 - 1.3 7.7 4.1 1.5 7.5 4.1 1.1 1 0 0 1 1 1 0 Transglutaminase elicitor 3Beta_HSD PF01073.19 VDK85268.1 - 1.6e-40 138.9 0.0 2.1e-40 138.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 VDK85268.1 - 1.4e-24 86.9 0.0 1.8e-24 86.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 VDK85268.1 - 3.5e-10 39.8 0.0 6.6e-10 38.9 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 VDK85268.1 - 1.2e-09 38.3 0.0 2.1e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 VDK85268.1 - 5.8e-08 32.2 0.0 8.1e-08 31.7 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 VDK85268.1 - 1.5e-06 27.6 0.1 5.3e-06 25.8 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 VDK85268.1 - 2.4e-05 23.7 0.0 4.5e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Male sterility protein NmrA PF05368.13 VDK85268.1 - 8.1e-05 22.3 0.0 0.00022 20.9 0.0 1.8 1 1 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 VDK85268.1 - 0.01 16.1 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain adh_short PF00106.25 VDK85268.1 - 0.028 13.9 0.2 0.88 9.0 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase LURAP PF14854.6 VDK85270.1 - 0.043 13.8 0.0 0.093 12.7 0.0 1.6 1 0 0 1 1 1 0 Leucine rich adaptor protein Paramyxo_P_V_N PF13825.6 VDK85272.1 - 0.064 12.7 0.0 0.071 12.5 0.0 1.0 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus CorA PF01544.18 VDK85273.1 - 0.014 14.8 3.5 0.028 13.7 3.5 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Com_YlbF PF06133.11 VDK85273.1 - 0.13 12.9 10.8 0.62 10.7 10.8 2.2 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA HSBP1 PF06825.12 VDK85273.1 - 2.1 8.2 7.9 16 5.4 0.8 3.7 4 0 0 4 4 4 0 Heat shock factor binding protein 1 Mod_r PF07200.13 VDK85273.1 - 4.7 7.3 15.1 20 5.3 11.1 2.8 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FancD2 PF14631.6 VDK85274.1 - 3.1e-45 154.2 35.6 1.9e-31 108.5 2.9 4.0 2 1 0 2 2 2 2 Fanconi anaemia protein FancD2 nuclease Per1 PF04080.13 VDK85275.1 - 6.7e-65 219.4 24.6 9.3e-65 218.9 24.6 1.1 1 0 0 1 1 1 1 Per1-like family DUF2304 PF10066.9 VDK85275.1 - 0.88 9.8 21.5 0.21 11.8 2.3 3.3 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2304) JAMP PF05571.12 VDK85276.1 - 1.2e-90 304.1 22.3 1.3e-90 304.0 22.3 1.0 1 0 0 1 1 1 1 JNK1/MAPK8-associated membrane protein Seipin PF06775.14 VDK85278.1 - 1.5e-25 90.5 0.9 2.1e-25 90.0 0.9 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) p12I PF12233.8 VDK85278.1 - 1.6 9.3 7.6 0.21 12.1 2.3 2.1 2 0 0 2 2 2 0 Human adult T cell leukemia/lymphoma virus protein Dishevelled PF02377.15 VDK85286.1 - 0.035 14.6 0.1 0.048 14.1 0.1 1.2 1 0 0 1 1 1 0 Dishevelled specific domain HGTP_anticodon PF03129.20 VDK85287.1 - 2.4e-14 53.2 0.0 8.8e-14 51.4 0.0 2.1 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 VDK85287.1 - 5.8e-11 42.7 0.1 2.5e-10 40.6 0.0 2.3 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS PF00458.20 VDK85287.1 - 5.3e-10 39.3 4.4 1.5e-09 37.8 4.4 1.8 1 0 0 1 1 1 1 WHEP-TRS domain APG6_N PF17675.1 VDK85287.1 - 0.74 10.4 7.3 0.59 10.7 0.3 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Rpn3_C PF08375.11 VDK85288.1 - 1.1e-24 86.7 2.3 1.1e-24 86.7 2.3 2.1 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 VDK85288.1 - 2.1e-18 66.7 0.1 2.1e-18 66.7 0.1 2.3 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 VDK85288.1 - 0.0077 16.3 5.2 0.12 12.5 0.5 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 VDK85288.1 - 0.018 15.0 0.1 0.042 13.8 0.1 1.7 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family CKAP2_C PF15297.6 VDK85288.1 - 0.023 13.8 0.8 0.039 13.1 0.8 1.3 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus TPR_16 PF13432.6 VDK85288.1 - 0.067 13.9 2.5 11 6.8 1.8 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK85288.1 - 5.3 7.0 7.6 12 5.9 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L32p PF01783.23 VDK85289.1 - 0.014 15.6 3.2 0.024 14.9 3.2 1.4 1 0 0 1 1 1 0 Ribosomal L32p protein family RecR PF02132.15 VDK85289.1 - 0.043 13.4 1.3 0.12 12.0 1.3 1.7 1 0 0 1 1 1 0 RecR protein zinc-ribbons_6 PF07191.12 VDK85289.1 - 0.071 13.1 2.0 0.12 12.4 2.0 1.3 1 0 0 1 1 1 0 zinc-ribbons OHCU_decarbox PF09349.10 VDK85289.1 - 0.18 12.3 0.0 0.23 12.0 0.0 1.2 1 0 0 1 1 1 0 OHCU decarboxylase HSP70 PF00012.20 VDK85292.1 - 3.6e-172 573.7 7.1 3.6e-172 573.7 7.1 2.2 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 VDK85292.1 - 1.3e-05 24.2 0.0 2.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 VDK85292.1 - 0.0034 17.1 0.0 0.0075 16.0 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain ANAPC4_WD40 PF12894.7 VDK85302.1 - 1e-08 35.3 0.7 0.16 12.2 0.0 5.5 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 VDK85302.1 - 4.4e-05 22.7 16.4 0.002 17.3 0.3 5.0 6 0 0 6 6 6 2 Coatomer WD associated region WD40 PF00400.32 VDK85302.1 - 0.007 17.2 5.5 57 4.8 0.1 5.7 6 0 0 6 6 6 0 WD domain, G-beta repeat PD40 PF07676.12 VDK85302.1 - 0.0078 16.1 0.1 0.87 9.6 0.0 2.9 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat TPR_12 PF13424.6 VDK85302.1 - 0.019 15.2 7.2 0.044 14.1 0.1 4.0 3 1 0 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.20 VDK85302.1 - 0.14 12.1 9.8 2.3 8.1 0.4 4.9 5 0 0 5 5 5 0 Region in Clathrin and VPS TPR_16 PF13432.6 VDK85302.1 - 0.2 12.3 7.0 1.8 9.3 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 VDK85302.1 - 0.25 11.6 10.3 0.31 11.2 1.2 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK85302.1 - 0.28 11.3 8.8 0.6 10.3 0.5 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK85302.1 - 2 8.3 7.0 0.52 10.2 0.8 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK85302.1 - 2.3 8.5 14.0 0.3 11.3 0.6 4.6 4 2 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-C4H2 PF10146.9 VDK85302.1 - 3.3 8.0 6.9 19 5.5 6.9 2.2 1 1 0 1 1 1 0 Zinc finger-containing protein Septin PF00735.18 VDK85306.1 - 4.5e-97 324.7 0.2 7.3e-97 324.0 0.2 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 VDK85306.1 - 0.00064 19.8 0.0 0.0015 18.6 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 VDK85306.1 - 0.0017 18.0 1.2 2 7.9 0.7 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 VDK85306.1 - 0.0032 17.8 0.0 0.01 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDK85306.1 - 0.011 16.1 0.0 0.05 14.0 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 VDK85306.1 - 0.012 15.8 0.0 0.043 14.0 0.0 1.9 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 VDK85306.1 - 0.014 15.3 0.0 0.83 9.5 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 VDK85306.1 - 0.021 14.3 0.0 0.042 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF1890 PF09001.11 VDK85306.1 - 0.032 14.6 0.1 0.14 12.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1890) PduV-EutP PF10662.9 VDK85306.1 - 0.071 12.8 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF87 PF01935.17 VDK85306.1 - 0.11 12.5 1.5 13 5.7 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 VDK85306.1 - 0.29 10.5 1.5 9.3 5.5 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Motile_Sperm PF00635.26 VDK85310.1 - 9.4e-17 60.8 0.2 1.5e-16 60.2 0.2 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain TB2_DP1_HVA22 PF03134.19 VDK85310.1 - 2.4e-05 24.2 0.2 5.1e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family WD40 PF00400.32 VDK85311.1 - 7.8e-05 23.4 5.6 0.059 14.3 0.9 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 VDK85312.1 - 8.3e-05 23.3 7.3 0.0069 17.2 0.9 4.5 3 2 0 3 3 3 2 WD domain, G-beta repeat DUF19 PF01579.18 VDK85314.1 - 0.0019 18.0 6.6 0.0019 18.0 6.6 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF19) TMEM154 PF15102.6 VDK85317.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family HEAT_2 PF13646.6 VDK85318.1 - 0.00043 20.6 0.4 0.81 10.1 0.0 3.9 3 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 VDK85318.1 - 0.0019 18.3 0.9 29 5.3 0.0 5.5 5 0 0 5 5 5 2 HEAT repeat Arm PF00514.23 VDK85318.1 - 0.018 15.0 0.0 0.097 12.7 0.0 2.3 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat His_Phos_1 PF00300.22 VDK85319.1 - 1.3e-25 90.2 0.0 1.6e-25 89.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Metallophos PF00149.28 VDK85322.1 - 1.3e-06 29.0 0.3 1.7e-06 28.7 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NIR_SIR PF01077.22 VDK85322.1 - 0.051 13.1 0.0 0.13 11.8 0.0 1.6 1 1 0 1 1 1 0 Nitrite and sulphite reductase 4Fe-4S domain DCP1 PF06058.13 VDK85327.1 - 2.9e-36 123.9 0.0 4.5e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family DUF4993 PF16384.5 VDK85327.1 - 0.091 11.7 0.0 0.15 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function Dynamin_M PF01031.20 VDK85328.1 - 1.9e-100 335.8 0.1 5.2e-100 334.3 0.0 1.8 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 VDK85328.1 - 1.3e-52 178.2 0.5 2e-51 174.4 0.0 2.5 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 VDK85328.1 - 2.4e-31 107.7 3.8 5.8e-31 106.5 3.8 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 VDK85328.1 - 0.0011 19.1 1.9 0.021 14.9 0.4 3.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase FHA PF00498.26 VDK85330.1 - 4.2e-15 55.9 0.0 1.1e-14 54.6 0.0 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 VDK85330.1 - 0.0069 16.7 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF1465 PF07323.12 VDK85330.1 - 2.2 8.1 10.2 0.98 9.3 3.1 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1465) NTF2 PF02136.20 VDK85331.1 - 1.9e-27 96.2 0.3 5.6e-27 94.7 0.3 1.9 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 VDK85331.1 - 0.00073 19.3 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA PF00004.29 VDK85332.1 - 4.6e-12 46.5 0.0 1.2e-11 45.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 VDK85332.1 - 3.9e-06 27.3 0.0 1.6e-05 25.4 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 VDK85332.1 - 1.6e-05 25.0 0.0 3.7e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 VDK85332.1 - 4.1e-05 22.9 0.0 7.6e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 VDK85332.1 - 4.4e-05 23.7 0.0 0.00032 20.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 VDK85332.1 - 0.00011 22.0 0.0 0.00027 20.7 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 VDK85332.1 - 0.00032 20.5 0.0 0.00061 19.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 VDK85332.1 - 0.00034 20.6 0.0 0.0014 18.7 0.0 2.1 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 VDK85332.1 - 0.00064 19.5 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 VDK85332.1 - 0.00065 20.3 2.6 0.0047 17.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.6 VDK85332.1 - 0.0015 18.6 0.0 0.006 16.7 0.0 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_28 PF13521.6 VDK85332.1 - 0.0048 17.1 0.2 0.015 15.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain Rad17 PF03215.15 VDK85332.1 - 0.0052 16.7 0.0 0.23 11.4 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain PhoH PF02562.16 VDK85332.1 - 0.006 16.1 0.0 0.016 14.6 0.0 1.7 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 VDK85332.1 - 0.0061 16.8 0.1 0.082 13.2 0.1 2.7 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 VDK85332.1 - 0.0073 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 VDK85332.1 - 0.0099 15.5 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 VDK85332.1 - 0.022 14.8 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_6 PF12774.7 VDK85332.1 - 0.022 13.7 0.0 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region TIP49 PF06068.13 VDK85332.1 - 0.026 13.7 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain IPT PF01745.16 VDK85332.1 - 0.032 13.6 0.1 0.064 12.6 0.1 1.5 1 0 0 1 1 1 0 Isopentenyl transferase AAA_7 PF12775.7 VDK85332.1 - 0.039 13.5 0.0 0.12 11.9 0.0 1.8 2 0 0 2 2 1 0 P-loop containing dynein motor region NACHT PF05729.12 VDK85332.1 - 0.04 13.8 0.2 0.19 11.7 0.2 2.1 1 1 0 2 2 2 0 NACHT domain Cytidylate_kin PF02224.18 VDK85332.1 - 0.084 12.6 0.1 0.17 11.6 0.1 1.5 1 0 0 1 1 1 0 Cytidylate kinase T2SSE PF00437.20 VDK85332.1 - 0.15 11.1 0.0 0.3 10.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein SRP54 PF00448.22 VDK85332.1 - 0.21 11.2 0.0 0.41 10.2 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_17 PF13207.6 VDK85332.1 - 0.21 12.0 0.2 0.7 10.3 0.0 2.0 2 0 0 2 2 1 0 AAA domain TP6A_N PF04406.14 VDK85334.1 - 1.7e-14 53.6 0.2 3.1e-14 52.7 0.2 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase RRM_1 PF00076.22 VDK85343.1 - 1.4e-28 98.5 0.0 2.8e-17 62.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 VDK85343.1 - 0.0016 18.7 0.0 1.9 8.7 0.1 2.6 1 1 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RRM_3 PF08777.11 VDK85343.1 - 0.023 14.7 0.0 0.62 10.1 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 VDK85343.1 - 0.031 14.4 0.0 0.27 11.4 0.0 2.3 2 1 0 2 2 2 0 RNA recognition motif F-box-like PF12937.7 VDK85344.1 - 6.1e-14 51.6 3.7 1.4e-13 50.5 0.4 2.9 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 VDK85344.1 - 1.7e-08 34.1 0.7 6.2e-08 32.3 0.1 2.4 2 0 0 2 2 2 1 F-box domain MinC_N PF05209.13 VDK85344.1 - 0.14 12.1 0.0 28 4.7 0.0 2.9 3 0 0 3 3 3 0 Septum formation inhibitor MinC, N-terminal domain Protocadherin PF08374.11 VDK85360.1 - 0.0025 17.8 5.9 0.0025 17.8 5.9 2.3 1 1 1 2 2 2 1 Protocadherin SIT PF15330.6 VDK85360.1 - 0.058 13.8 0.2 0.058 13.8 0.2 2.5 2 1 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Neur_chan_memb PF02932.16 VDK85360.1 - 2.1 8.3 11.7 4.7 7.2 11.7 1.5 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1179 PF06678.11 VDK85360.1 - 5 7.2 13.5 4 7.5 0.5 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1179) RRM_1 PF00076.22 VDK85361.1 - 2.1e-60 200.5 1.0 6.4e-22 77.2 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDK85361.1 - 7.4e-09 35.3 0.0 0.0006 19.4 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDK85361.1 - 2e-07 30.7 0.0 0.00018 21.3 0.0 2.5 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_7 PF16367.5 VDK85361.1 - 1.2e-05 25.3 0.5 0.43 10.7 0.0 4.6 3 2 0 3 3 3 1 RNA recognition motif PHM7_cyt PF14703.6 VDK85361.1 - 4e-05 23.9 0.0 0.12 12.6 0.0 3.4 3 0 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 VDK85361.1 - 0.0003 20.7 0.3 1.1 9.3 0.0 3.5 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 VDK85361.1 - 0.00089 19.1 0.0 0.017 14.9 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1866) Limkain-b1 PF11608.8 VDK85361.1 - 0.00096 19.2 0.2 0.046 13.8 0.0 2.9 3 0 0 3 3 3 1 Limkain b1 DUF4523 PF15023.6 VDK85361.1 - 0.0013 18.6 0.0 0.066 13.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4523) RRM_3 PF08777.11 VDK85361.1 - 0.0043 17.1 0.1 0.9 9.6 0.0 3.1 3 0 0 3 3 3 1 RNA binding motif Calcipressin PF04847.12 VDK85361.1 - 0.022 14.5 0.2 0.078 12.7 0.0 1.9 2 0 0 2 2 2 0 Calcipressin RL PF17797.1 VDK85361.1 - 0.043 13.8 0.0 2.1 8.3 0.0 2.6 2 0 0 2 2 2 0 RL domain SET_assoc PF11767.8 VDK85361.1 - 0.18 11.5 0.5 52 3.6 0.0 3.1 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Thioredoxin_8 PF13905.6 VDK85362.1 - 2e-33 114.6 0.0 2.4e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 VDK85362.1 - 3.2e-12 46.3 0.0 6.8e-09 35.7 0.0 2.1 2 0 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 VDK85362.1 - 4.1e-11 42.8 0.0 4.8e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 VDK85362.1 - 5e-10 39.4 0.0 5.7e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 VDK85362.1 - 3.1e-07 30.8 0.0 3.9e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 VDK85362.1 - 8.7e-06 25.5 0.0 0.00011 22.0 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 VDK85362.1 - 0.00023 21.3 0.1 0.0032 17.6 0.1 2.2 1 1 1 2 2 2 1 Thioredoxin-like TraF PF13728.6 VDK85362.1 - 0.00083 19.2 0.0 0.0011 18.8 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Glutaredoxin PF00462.24 VDK85362.1 - 0.046 13.9 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin Thioredoxin_4 PF13462.6 VDK85362.1 - 0.094 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin DUF953 PF06110.11 VDK85362.1 - 0.1 12.3 0.1 0.46 10.1 0.1 2.1 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Toprim_3 PF13362.6 VDK85362.1 - 0.12 12.7 0.0 4.1 7.8 0.0 2.3 1 1 1 2 2 2 0 Toprim domain DSBA PF01323.20 VDK85362.1 - 0.17 11.6 0.1 9.4 6.0 0.1 2.1 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Thioredoxin_8 PF13905.6 VDK85363.1 - 5.3e-34 116.4 0.0 6.6e-34 116.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 VDK85363.1 - 2.1e-12 46.9 0.2 6.5e-09 35.7 0.1 2.2 1 1 1 2 2 2 2 Thioredoxin AhpC-TSA PF00578.21 VDK85363.1 - 1.2e-10 41.3 0.0 1.5e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK85363.1 - 2.1e-10 40.5 0.0 2.4e-10 40.3 0.0 1.0 1 0 0 1 1 1 1 Redoxin Thioredoxin_2 PF13098.6 VDK85363.1 - 3e-08 34.1 0.0 3.7e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 VDK85363.1 - 1.3e-05 25.0 0.0 0.00024 20.9 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin TraF PF13728.6 VDK85363.1 - 0.00058 19.8 0.0 0.0008 19.3 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 VDK85363.1 - 0.0021 18.2 0.1 0.03 14.5 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like SCO1-SenC PF02630.14 VDK85363.1 - 0.0039 17.1 0.0 0.0049 16.8 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_4 PF13462.6 VDK85363.1 - 0.016 15.4 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin DUF953 PF06110.11 VDK85363.1 - 0.026 14.1 0.1 0.14 11.8 0.1 2.1 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin_3 PF13192.6 VDK85363.1 - 0.049 13.7 0.0 8.6 6.5 0.1 2.6 1 1 1 2 2 2 0 Thioredoxin domain DSBA PF01323.20 VDK85363.1 - 0.059 13.1 0.1 5.7 6.7 0.1 2.1 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Toprim_3 PF13362.6 VDK85363.1 - 0.067 13.6 0.0 8.5 6.8 0.0 2.2 1 1 1 2 2 2 0 Toprim domain Atg8 PF02991.16 VDK85364.1 - 1.7e-49 166.3 0.2 2e-49 166.1 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 VDK85364.1 - 8.8e-06 26.0 0.0 1.1e-05 25.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 SH3_2 PF07653.17 VDK85376.1 - 1.9e-15 56.3 0.0 8.5e-08 31.8 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 VDK85376.1 - 2.2e-10 40.2 0.0 0.00034 20.4 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 VDK85376.1 - 1.7e-05 24.3 0.3 0.14 11.8 0.0 2.9 2 2 0 2 2 2 2 SH3 domain COMM_domain PF07258.14 VDK85377.1 - 0.0014 18.7 0.3 0.0018 18.3 0.3 1.2 1 0 0 1 1 1 1 COMM domain tRNA_anti-codon PF01336.25 VDK85378.1 - 7.8e-07 29.0 0.1 1e-06 28.6 0.1 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain SAM_1 PF00536.30 VDK85378.1 - 0.098 13.1 0.1 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) tRNA-synt_2 PF00152.20 VDK85380.1 - 4.4e-66 223.1 0.0 5.5e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Dimeth_Pyl PF09505.10 VDK85380.1 - 0.17 10.4 0.0 0.32 9.5 0.0 1.4 1 1 0 1 1 1 0 Dimethylamine methyltransferase (Dimeth_PyL) Zincin_2 PF10103.9 VDK85380.1 - 0.18 11.1 0.0 0.24 10.6 0.0 1.1 1 0 0 1 1 1 0 Zincin-like metallopeptidase RNase_P_Rpp14 PF01900.19 VDK85381.1 - 1.7e-17 63.6 0.1 3.2e-17 62.7 0.0 1.5 2 0 0 2 2 2 1 Rpp14/Pop5 family ACBP PF00887.19 VDK85383.1 - 2.6e-19 69.2 0.0 4.2e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein DUF5423 PF17461.2 VDK85383.1 - 0.087 11.7 0.1 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) CENP-F_leu_zip PF10473.9 VDK85384.1 - 0.00096 19.2 4.4 0.00096 19.2 4.4 2.1 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Wbp11 PF09429.10 VDK85384.1 - 0.11 12.9 9.4 3.3 8.2 0.2 2.3 2 0 0 2 2 2 0 WW domain binding protein 11 Suppressor_APC PF11414.8 VDK85384.1 - 0.11 12.6 4.6 0.32 11.1 1.8 2.2 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein Myb_DNA-bind_3 PF12776.7 VDK85384.1 - 0.16 12.9 3.3 0.12 13.4 1.7 1.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain bZIP_2 PF07716.15 VDK85384.1 - 0.33 11.1 12.3 0.087 12.9 5.3 2.8 2 1 1 3 3 3 0 Basic region leucine zipper DUF2951 PF11166.8 VDK85384.1 - 0.39 11.0 12.4 1.7 8.9 10.0 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF2951) DUF4140 PF13600.6 VDK85384.1 - 0.45 11.0 3.8 3.3 8.2 1.1 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF5102 PF17104.5 VDK85384.1 - 1.1 9.2 6.0 4.1 7.3 2.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) XhlA PF10779.9 VDK85384.1 - 4 7.7 11.0 2.4 8.4 3.8 2.9 2 1 2 4 4 4 0 Haemolysin XhlA ATP-synt_D PF01813.17 VDK85385.1 - 1.7e-70 236.9 1.0 2.2e-70 236.5 1.0 1.2 1 0 0 1 1 1 1 ATP synthase subunit D Methyltransf_3 PF01596.17 VDK85391.1 - 8.8e-53 178.6 0.1 1.1e-52 178.3 0.1 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 VDK85391.1 - 4.8e-08 34.0 0.0 1.1e-07 32.8 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK85391.1 - 7e-05 22.7 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK85391.1 - 0.0052 17.5 0.0 0.016 15.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain DUF2187 PF09953.9 VDK85391.1 - 0.027 14.4 0.3 0.051 13.6 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) CMAS PF02353.20 VDK85391.1 - 0.075 12.3 0.0 0.26 10.6 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 VDK85391.1 - 0.11 12.2 0.1 0.23 11.2 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PAP_assoc PF03828.19 VDK85392.1 - 2.6e-14 53.2 0.3 7.8e-14 51.6 0.3 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 VDK85392.1 - 0.065 13.5 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Nucleotidyltransferase domain Peptidase_M1 PF01433.20 VDK85394.1 - 5.3e-86 287.7 0.3 8.9e-86 286.9 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 VDK85394.1 - 6.8e-68 229.5 0.0 5.4e-67 226.6 0.0 2.1 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 VDK85394.1 - 2.9e-52 177.6 0.1 4.7e-52 176.9 0.1 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF3458 PF11940.8 VDK85394.1 - 0.0025 18.2 0.0 0.06 13.8 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3458) Ig-like fold SprT-like PF10263.9 VDK85394.1 - 0.09 12.6 0.1 3.8 7.4 0.0 2.9 3 0 0 3 3 3 0 SprT-like family Clc-like PF07062.12 VDK85395.1 - 6.2e-43 146.7 13.0 1.1e-42 145.9 13.0 1.3 1 1 0 1 1 1 1 Clc-like Claudin_2 PF13903.6 VDK85395.1 - 5.7e-06 26.2 9.6 5.7e-06 26.2 9.6 1.7 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction PMP22_Claudin PF00822.20 VDK85395.1 - 0.0047 16.8 16.3 0.03 14.2 0.1 2.3 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin family Claudin_3 PF06653.11 VDK85395.1 - 1.1 9.1 19.3 37 4.2 19.3 2.3 1 1 0 1 1 1 0 Tight junction protein, Claudin-like Neurensin PF14927.6 VDK85395.1 - 1.7 8.4 4.6 1.7 8.3 0.0 2.7 3 1 0 3 3 3 0 Neurensin DUF4491 PF14898.6 VDK85395.1 - 1.8 9.1 7.9 0.53 10.8 1.1 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4491) LapA_dom PF06305.11 VDK85395.1 - 3.5 7.5 7.6 0.71 9.7 2.5 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Clc-like PF07062.12 VDK85396.1 - 7.6e-15 55.0 7.8 1.1e-11 44.7 3.6 2.1 2 0 0 2 2 2 2 Clc-like DUF2721 PF11026.8 VDK85396.1 - 0.54 10.1 5.0 0.21 11.5 2.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) PrmA PF06325.13 VDK85397.1 - 7.3e-08 32.1 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 VDK85397.1 - 8.5e-06 26.4 0.0 5.7e-05 23.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 VDK85397.1 - 8.7e-05 22.1 0.2 0.0025 17.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 VDK85397.1 - 0.00084 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 VDK85397.1 - 0.0023 17.1 0.1 0.0058 15.7 0.0 1.6 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase Cons_hypoth95 PF03602.15 VDK85397.1 - 0.0052 16.5 0.1 0.021 14.4 0.1 1.8 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 VDK85397.1 - 0.0077 16.9 0.0 0.021 15.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 VDK85397.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 VDK85397.1 - 0.018 15.0 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 VDK85397.1 - 0.047 13.5 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ank_2 PF12796.7 VDK85398.1 - 1.2e-13 51.4 0.1 1.7e-10 41.3 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK85398.1 - 9.3e-13 48.1 0.1 1.2e-07 31.9 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 VDK85398.1 - 4.8e-10 39.8 0.1 0.00023 21.7 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK85398.1 - 1.2e-05 25.3 0.1 0.06 13.9 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat zf-MYND PF01753.18 VDK85398.1 - 1.7e-05 24.8 16.8 4.7e-05 23.4 16.8 1.8 1 0 0 1 1 1 1 MYND finger Ank PF00023.30 VDK85398.1 - 2.4e-05 24.5 0.1 0.26 11.8 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat YpjP PF14005.6 VDK85398.1 - 0.11 12.6 0.4 1.1 9.3 0.1 2.3 2 0 0 2 2 2 0 YpjP-like protein DUF1836 PF08876.11 VDK85398.1 - 0.16 12.0 1.2 1.6 8.8 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1836) cwf18 PF08315.12 VDK85399.1 - 9.3e-30 104.0 12.7 1.2e-29 103.7 12.7 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor Cnn_1N PF07989.11 VDK85399.1 - 0.054 13.7 6.9 1.1 9.5 3.1 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 RHH_1 PF01402.21 VDK85399.1 - 4.3 7.4 10.7 0.59 10.1 3.6 2.6 2 1 0 2 2 2 0 Ribbon-helix-helix protein, copG family Ribosomal_L22 PF00237.19 VDK85400.1 - 7.4e-16 58.3 0.3 1.1e-15 57.7 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Exo_endo_phos PF03372.23 VDK85403.1 - 3.2e-16 59.6 0.0 4.3e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Syd PF07348.12 VDK85403.1 - 0.13 12.0 0.1 0.36 10.5 0.0 1.7 2 0 0 2 2 2 0 Syd protein (SUKH-2) COX6A PF02046.15 VDK85405.1 - 1.7e-09 38.1 1.1 2.4e-09 37.6 1.1 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIa I-set PF07679.16 VDK85415.1 - 5.3e-35 119.4 0.6 1.3e-15 57.2 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK85415.1 - 2e-34 118.0 0.7 4e-17 62.6 0.3 3.3 3 0 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 VDK85415.1 - 7.3e-25 87.0 0.1 2.3e-11 43.7 0.0 3.5 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 VDK85415.1 - 1.4e-23 83.2 1.3 5.1e-07 29.8 0.0 4.2 3 1 1 4 4 4 4 Immunoglobulin V-set domain Ig_2 PF13895.6 VDK85415.1 - 4.9e-23 81.3 0.5 6e-13 48.9 0.1 3.2 3 0 0 3 3 3 3 Immunoglobulin domain C2-set_2 PF08205.12 VDK85415.1 - 4.8e-06 26.5 0.1 0.0046 17.0 0.0 2.8 2 0 0 2 2 2 2 CD80-like C2-set immunoglobulin domain Ig_5 PF16681.5 VDK85415.1 - 7.2e-05 23.1 0.2 0.04 14.3 0.0 3.4 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 VDK85415.1 - 0.00033 20.8 0.2 0.014 15.6 0.0 3.2 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Izumo-Ig PF16706.5 VDK85415.1 - 0.0011 19.0 0.2 2.2 8.4 0.0 2.8 3 1 0 3 3 3 2 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 VDK85415.1 - 0.089 12.8 0.0 0.63 10.1 0.0 2.3 2 0 0 2 2 2 0 C17orf99 Ig domain Ig_6 PF18452.1 VDK85415.1 - 0.093 12.3 0.0 0.47 10.0 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain I-set PF07679.16 VDK85416.1 - 6.2e-05 23.0 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Immunoglobulin I-set domain fn3 PF00041.21 VDK85416.1 - 0.0029 17.9 0.1 0.0072 16.6 0.1 1.7 1 1 0 1 1 1 1 Fibronectin type III domain Ig_3 PF13927.6 VDK85416.1 - 0.0057 17.2 0.1 0.012 16.2 0.1 1.5 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 VDK85416.1 - 0.025 14.7 0.0 0.048 13.8 0.0 1.5 1 0 0 1 1 1 0 Immunoglobulin domain V-set PF07686.17 VDK85416.1 - 0.04 14.1 1.3 0.064 13.4 0.3 1.8 2 0 0 2 2 2 0 Immunoglobulin V-set domain SR-25 PF10500.9 VDK85423.1 - 4.9 6.7 21.7 9.3 5.8 21.7 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein C2 PF00168.30 VDK85424.1 - 9.2e-08 32.3 0.0 2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain Dus PF01207.17 VDK85425.1 - 9.1e-51 172.8 0.0 1.9e-50 171.8 0.0 1.5 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) MADF_DNA_bdg PF10545.9 VDK85425.1 - 4.2e-06 27.0 3.2 1.4e-05 25.3 3.2 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like zf-CCCH PF00642.24 VDK85425.1 - 0.033 14.1 7.3 0.084 12.8 3.6 2.9 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF241 PF03087.14 VDK85425.1 - 0.13 12.1 1.3 0.66 9.8 0.8 2.4 2 1 0 2 2 2 0 Arabidopsis protein of unknown function Mnd1 PF03962.15 VDK85438.1 - 1.1e-20 73.7 0.1 2.9e-20 72.3 0.1 1.8 1 0 0 1 1 1 1 Mnd1 HTH domain LZ3wCH PF18517.1 VDK85438.1 - 2.4e-20 72.4 2.4 2.4e-20 72.4 2.4 1.9 2 0 0 2 2 1 1 Leucine zipper with capping helix domain Fmp27_WPPW PF10359.9 VDK85438.1 - 0.0014 17.6 5.2 0.0018 17.3 5.2 1.0 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain FapA PF03961.13 VDK85438.1 - 0.0018 17.0 5.0 0.0022 16.7 5.0 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A Laminin_II PF06009.12 VDK85438.1 - 0.0022 18.0 5.3 0.004 17.2 5.3 1.4 1 0 0 1 1 1 1 Laminin Domain II ABC_tran_CTD PF16326.5 VDK85438.1 - 0.0026 18.0 12.5 0.0032 17.7 11.4 1.7 2 0 0 2 2 1 1 ABC transporter C-terminal domain Cob_adeno_trans PF01923.18 VDK85438.1 - 0.0029 17.8 0.5 0.0044 17.2 0.5 1.3 1 0 0 1 1 1 1 Cobalamin adenosyltransferase DUF2730 PF10805.8 VDK85438.1 - 0.0065 16.5 1.0 0.015 15.4 1.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2730) Allexi_40kDa PF05549.11 VDK85438.1 - 0.008 15.7 0.6 0.0097 15.5 0.6 1.1 1 0 0 1 1 1 1 Allexivirus 40kDa protein CK2S PF15011.6 VDK85438.1 - 0.011 15.6 1.3 0.054 13.4 0.6 2.0 1 1 1 2 2 2 0 Casein Kinase 2 substrate CENP-F_leu_zip PF10473.9 VDK85438.1 - 0.011 15.7 10.4 0.019 15.0 10.4 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Wx5_PLAF3D7 PF09688.10 VDK85438.1 - 0.024 14.7 3.8 0.033 14.2 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (Wx5_PLAF3D7) LPP PF04728.13 VDK85438.1 - 0.035 14.5 5.9 0.6 10.5 0.5 2.8 2 1 0 2 2 2 0 Lipoprotein leucine-zipper DUF812 PF05667.11 VDK85438.1 - 0.058 12.3 7.7 0.073 11.9 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) V_ATPase_I PF01496.19 VDK85438.1 - 0.1 10.5 1.7 0.11 10.4 1.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Seryl_tRNA_N PF02403.22 VDK85438.1 - 0.1 12.8 9.8 0.42 10.9 9.7 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.7 VDK85438.1 - 0.11 12.6 14.8 0.19 11.9 14.7 1.4 1 1 0 1 1 1 0 Tropomyosin like Atg14 PF10186.9 VDK85438.1 - 0.12 11.4 3.5 0.15 11.1 3.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NPV_P10 PF05531.12 VDK85438.1 - 0.15 12.6 5.9 1.9 9.0 4.3 2.6 2 1 1 3 3 2 0 Nucleopolyhedrovirus P10 protein XhlA PF10779.9 VDK85438.1 - 0.17 12.1 7.8 0.8 10.0 3.4 2.5 1 1 1 2 2 2 0 Haemolysin XhlA Med9 PF07544.13 VDK85438.1 - 0.17 12.0 8.0 0.44 10.7 8.0 1.7 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 FAM76 PF16046.5 VDK85438.1 - 0.2 11.0 9.5 0.069 12.5 6.5 1.6 2 0 0 2 2 2 0 FAM76 protein DUF1515 PF07439.11 VDK85438.1 - 0.22 11.6 1.3 0.36 10.9 0.7 1.6 1 1 1 2 2 1 0 Protein of unknown function (DUF1515) Spc24 PF08286.11 VDK85438.1 - 0.23 11.7 9.3 1.2 9.4 2.1 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DivIC PF04977.15 VDK85438.1 - 0.24 11.2 9.3 1.6 8.5 1.1 2.4 1 1 1 2 2 2 0 Septum formation initiator DHR10 PF18595.1 VDK85438.1 - 0.24 11.5 11.7 0.62 10.1 11.7 1.7 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain SlyX PF04102.12 VDK85438.1 - 0.28 11.8 4.1 3.2 8.4 0.2 2.4 1 1 1 2 2 2 0 SlyX DUF4140 PF13600.6 VDK85438.1 - 0.4 11.2 8.6 4.7 7.7 1.5 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Synaptonemal_3 PF15191.6 VDK85438.1 - 0.41 10.5 3.3 0.43 10.4 1.0 2.1 1 1 1 2 2 2 0 Synaptonemal complex central element protein 3 GAS PF13851.6 VDK85438.1 - 0.42 9.9 13.6 0.92 8.8 13.6 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding CLZ PF16526.5 VDK85438.1 - 0.43 11.0 8.9 2 8.9 8.3 2.2 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ZapB PF06005.12 VDK85438.1 - 0.46 11.0 13.5 0.65 10.5 6.4 2.3 1 1 1 2 2 2 0 Cell division protein ZapB YabA PF06156.13 VDK85438.1 - 0.63 10.7 6.5 1.2 9.8 6.5 1.7 1 1 0 1 1 1 0 Initiation control protein YabA Uso1_p115_C PF04871.13 VDK85438.1 - 0.79 10.1 15.7 0.34 11.3 12.7 1.7 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FlaC_arch PF05377.11 VDK85438.1 - 1.1 9.7 7.0 5.1 7.6 0.8 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) FlxA PF14282.6 VDK85438.1 - 1.5 8.9 7.9 5.9 6.9 7.9 2.0 1 1 0 1 1 1 0 FlxA-like protein DUF1664 PF07889.12 VDK85438.1 - 1.5 8.9 5.0 4.7 7.3 4.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) CSN5_C PF18323.1 VDK85438.1 - 1.6 9.7 9.8 0.69 10.9 4.0 2.7 2 1 1 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain TPR_MLP1_2 PF07926.12 VDK85438.1 - 2.7 8.1 15.0 2.1 8.4 10.8 2.2 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF724 PF05266.14 VDK85438.1 - 4.5 7.1 11.0 2.7 7.8 7.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.13 VDK85438.1 - 4.9 6.3 6.6 7.1 5.8 6.0 1.5 1 1 0 1 1 1 0 TMPIT-like protein GrpE PF01025.19 VDK85438.1 - 5.1 6.7 10.9 2.7e+02 1.1 10.9 2.2 1 1 0 1 1 1 0 GrpE Swi5 PF07061.11 VDK85438.1 - 6.1 7.0 10.8 6.9 6.8 4.4 2.6 1 1 1 2 2 2 0 Swi5 DUF465 PF04325.13 VDK85438.1 - 7.4 6.7 12.1 26 5.0 4.4 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF465) Ax_dynein_light PF10211.9 VDK85438.1 - 9.3 6.2 14.5 21 5.0 6.4 2.5 1 1 2 3 3 3 0 Axonemal dynein light chain PspA_IM30 PF04012.12 VDK85440.1 - 0.0085 15.7 0.2 0.024 14.2 0.2 1.8 1 0 0 1 1 1 1 PspA/IM30 family Cnn_1N PF07989.11 VDK85440.1 - 3.7 7.8 10.0 2.9 8.1 4.0 3.0 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Pro_isomerase PF00160.21 VDK85442.1 - 2.7e-49 167.5 0.3 3e-49 167.3 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-C2H2_4 PF13894.6 VDK85443.1 - 9e-08 32.3 59.8 0.0054 17.5 1.5 8.7 8 0 0 8 8 8 4 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK85443.1 - 8.4e-05 22.8 63.2 0.04 14.4 2.0 8.8 8 0 0 8 8 8 6 Zinc finger, C2H2 type zf-Di19 PF05605.12 VDK85443.1 - 0.00011 22.4 40.7 0.0012 19.1 3.2 5.4 3 1 1 5 5 5 2 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 VDK85443.1 - 0.033 14.6 0.1 0.033 14.6 0.1 6.2 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK85443.1 - 0.035 14.4 0.9 0.035 14.4 0.9 6.4 7 0 0 7 7 7 0 Zinc-finger double-stranded RNA-binding Hint_2 PF13403.6 VDK85443.1 - 0.069 13.4 0.0 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 Hint domain Zn-C2H2_12 PF18112.1 VDK85443.1 - 0.24 11.9 7.6 1.2 9.7 0.2 4.0 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_3rep PF18868.1 VDK85443.1 - 0.32 11.7 22.4 0.83 10.3 0.2 4.7 3 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats DUF629 PF04780.12 VDK85443.1 - 0.82 8.1 0.0 0.82 8.1 0.0 4.2 4 1 0 4 4 4 0 Protein of unknown function (DUF629) zf-C2H2_9 PF16293.5 VDK85443.1 - 4.6 7.2 12.8 5.1 7.0 0.1 4.2 5 0 0 5 5 5 0 C2H2 type zinc-finger (1 copy) Collagen PF01391.18 VDK85445.1 - 1.8e-09 37.2 20.0 2.2e-09 36.9 20.0 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TUDOR PF00567.24 VDK85450.1 - 8.5e-19 67.8 0.6 2.7e-07 30.6 0.1 3.3 3 0 0 3 3 3 3 Tudor domain Ribosomal_L10 PF00466.20 VDK85452.1 - 0.011 15.9 0.1 0.024 14.8 0.1 1.6 1 1 0 1 1 1 0 Ribosomal protein L10 DAP3 PF10236.9 VDK85453.1 - 1e-49 169.4 0.0 1.3e-49 169.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 ResIII PF04851.15 VDK85453.1 - 0.086 12.8 0.3 0.22 11.5 0.2 1.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit HEAT_2 PF13646.6 VDK85454.1 - 5.1e-27 94.1 1.4 4.3e-11 43.1 0.1 3.7 2 2 2 4 4 4 3 HEAT repeats HEAT_PBS PF03130.16 VDK85454.1 - 4.1e-20 70.4 1.2 0.0077 16.8 0.0 6.4 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 VDK85454.1 - 5.6e-06 26.2 4.1 0.26 11.7 0.0 5.9 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 VDK85454.1 - 2.6e-05 24.6 0.4 0.9 10.1 0.0 4.6 4 1 1 5 5 5 1 HEAT-like repeat DNA_pol_A_exo1 PF01612.20 VDK85455.1 - 9.8e-20 71.0 0.0 2.6e-11 43.6 0.0 2.3 2 0 0 2 2 2 2 3'-5' exonuclease Collagen PF01391.18 VDK85457.1 - 2e-16 59.5 55.5 2.2e-09 37.0 28.6 3.6 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK85457.1 - 0.00065 19.7 0.1 0.0011 19.0 0.1 1.4 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Glutaminase PF04960.15 VDK85460.1 - 8.3e-81 271.3 0.0 1.1e-80 270.9 0.0 1.1 1 0 0 1 1 1 1 Glutaminase Ank_2 PF12796.7 VDK85460.1 - 4.2e-11 43.3 0.0 1.9e-06 28.4 0.0 2.5 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK85460.1 - 1.9e-09 37.9 0.1 0.00016 22.2 0.0 3.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 VDK85460.1 - 0.00011 22.5 0.0 0.0095 16.4 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 VDK85460.1 - 0.00022 21.4 0.0 0.13 12.6 0.1 3.2 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK85460.1 - 0.00034 20.8 0.0 0.0039 17.6 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat Filo_VP35 PF02097.15 VDK85460.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Filoviridae VP35 Reprolysin_2 PF13574.6 VDK85461.1 - 2e-33 115.9 0.1 3.7e-33 115.1 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 VDK85461.1 - 3.7e-33 115.4 0.7 3.7e-33 115.4 0.7 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 VDK85461.1 - 9.2e-17 61.7 0.3 1.5e-16 61.0 0.3 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 VDK85461.1 - 1.4e-15 57.9 17.6 1.4e-15 57.9 17.6 3.2 2 1 0 2 2 2 1 Disintegrin ADAM17_MPD PF16698.5 VDK85461.1 - 2.2e-12 47.1 13.9 2.2e-12 47.1 13.9 3.7 2 1 1 3 3 3 1 Membrane-proximal domain, switch, for ADAM17 Reprolysin_4 PF13583.6 VDK85461.1 - 4.4e-11 42.8 1.3 2.5e-09 37.1 1.3 2.2 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 VDK85461.1 - 2.5e-07 30.8 0.0 0.00014 21.8 0.0 3.2 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 VDK85461.1 - 7.2e-07 29.5 0.1 1.5e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 Reprolysin family propeptide Peptidase_M66 PF10462.9 VDK85461.1 - 0.074 12.0 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 V-ATPase_H_N PF03224.14 VDK85462.1 - 1.6e-96 323.4 6.4 2.4e-96 322.7 6.4 1.3 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 VDK85462.1 - 2.7e-37 127.4 0.2 2.7e-37 127.4 0.2 2.6 3 0 0 3 3 3 1 V-ATPase subunit H Arm PF00514.23 VDK85462.1 - 0.0032 17.4 0.0 0.089 12.9 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat GDPD PF03009.17 VDK85462.1 - 0.1 12.3 0.8 2.9 7.6 0.1 2.9 1 1 2 4 4 4 0 Glycerophosphoryl diester phosphodiesterase family RIH_assoc PF08454.11 VDK85462.1 - 0.38 10.6 2.5 0.71 9.8 0.3 2.6 3 0 0 3 3 3 0 RyR and IP3R Homology associated Ribosomal_L5 PF00281.19 VDK85463.1 - 5.2e-22 77.9 0.0 2.3e-21 75.9 0.0 2.0 2 0 0 2 2 2 1 Ribosomal protein L5 Ribosomal_L5_C PF00673.21 VDK85463.1 - 1.6e-19 69.9 0.1 3.5e-19 68.8 0.0 1.6 2 0 0 2 2 2 1 ribosomal L5P family C-terminus RRN3 PF05327.11 VDK85464.1 - 2.5 6.5 9.7 3.9 5.9 9.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pkinase PF00069.25 VDK85465.1 - 4.4e-08 32.8 0.0 7.1e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85465.1 - 1.2e-05 24.7 0.0 1.7e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TniB PF05621.11 VDK85465.1 - 0.01 15.2 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Cupin_4 PF08007.12 VDK85470.1 - 4.7e-54 184.0 0.0 1.4e-53 182.5 0.0 1.7 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_8 PF13621.6 VDK85470.1 - 0.00053 19.8 4.7 0.00053 19.8 4.7 3.4 1 1 1 2 2 2 1 Cupin-like domain Cupin_1 PF00190.22 VDK85470.1 - 0.008 15.8 0.0 0.016 14.8 0.0 1.4 1 0 0 1 1 1 1 Cupin PXB PF12828.7 VDK85470.1 - 0.02 14.9 0.2 0.053 13.5 0.2 1.7 1 0 0 1 1 1 0 PX-associated Methyltransf_3 PF01596.17 VDK85472.1 - 7.2e-37 126.6 0.0 8.5e-37 126.4 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 VDK85472.1 - 2.1e-07 31.9 0.0 3.9e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PLDc_3 PF13918.6 VDK85473.1 - 1.9e-34 118.9 0.1 4.6e-34 117.6 0.1 1.7 2 0 0 2 2 2 1 PLD-like domain PLDc_2 PF13091.6 VDK85473.1 - 4.7e-24 84.8 0.1 1.4e-14 54.1 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 VDK85473.1 - 5.9e-14 51.6 3.7 3.2e-08 33.4 0.3 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PP_kinase_C PF13090.6 VDK85473.1 - 0.065 12.7 0.0 13 5.2 0.0 2.9 3 0 0 3 3 3 0 Polyphosphate kinase C-terminal domain 2 F-box PF00646.33 VDK85474.1 - 5.6e-12 45.2 1.1 1.9e-11 43.5 1.1 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 VDK85474.1 - 2.1e-10 40.3 0.5 5.5e-10 39.0 0.5 1.7 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 VDK85474.1 - 0.03 14.7 0.0 0.088 13.1 0.0 1.8 1 0 0 1 1 1 0 PRANC domain C2 PF00168.30 VDK85477.1 - 2.9e-44 149.6 0.1 5.7e-22 78.0 0.0 3.0 3 0 0 3 3 3 2 C2 domain FYVE_2 PF02318.16 VDK85477.1 - 4.7e-30 104.2 8.1 1.5e-29 102.6 8.1 1.9 1 0 0 1 1 1 1 FYVE-type zinc finger FYVE PF01363.21 VDK85477.1 - 1.8 8.8 9.4 5.2 7.3 9.4 1.7 1 0 0 1 1 1 0 FYVE zinc finger DUF525 PF04379.14 VDK85479.1 - 2.2e-12 47.1 0.1 3.6e-12 46.3 0.1 1.3 1 0 0 1 1 1 1 ApaG domain YccV-like PF08755.11 VDK85479.1 - 5.5e-06 26.8 0.0 2.1e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Hemimethylated DNA-binding protein YccV like Ubie_methyltran PF01209.18 VDK85480.1 - 1.4e-87 292.9 0.1 1.7e-87 292.6 0.1 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 VDK85480.1 - 1e-19 71.1 0.0 2.3e-19 69.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK85480.1 - 4e-19 69.0 0.0 9.4e-19 67.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK85480.1 - 1.7e-11 44.1 0.0 2.8e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK85480.1 - 5.5e-10 39.9 0.0 1.1e-09 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK85480.1 - 1.6e-08 34.5 0.0 2.4e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 VDK85480.1 - 0.0011 18.8 0.0 0.012 15.5 0.0 2.2 2 1 1 3 3 3 1 Hypothetical methyltransferase Darcynin PF17074.5 VDK85480.1 - 0.098 12.9 0.0 0.25 11.6 0.0 1.6 2 0 0 2 2 2 0 Darcynin, domain of unknown function Methyltransf_29 PF03141.16 VDK85480.1 - 0.15 10.6 0.0 0.18 10.3 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CAP_GLY PF01302.25 VDK85482.1 - 2.6e-16 59.4 2.2 7e-07 29.2 0.1 3.3 3 0 0 3 3 3 2 CAP-Gly domain UCH PF00443.29 VDK85482.1 - 0.0053 16.3 0.1 0.024 14.2 0.1 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Helicase_C PF00271.31 VDK85488.1 - 2.1e-05 24.8 0.1 4.7e-05 23.7 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Hamartin PF04388.12 VDK85489.1 - 4.1e-49 168.0 18.6 4.1e-49 168.0 18.6 3.4 2 1 0 2 2 2 1 Hamartin protein DUF4169 PF13770.6 VDK85489.1 - 0.0056 16.9 0.2 0.02 15.1 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4169) Fungal_TACC PF12709.7 VDK85489.1 - 4.7 7.7 14.2 25 5.4 0.1 4.2 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Peptidase_M10 PF00413.24 VDK85490.1 - 4.7e-34 117.5 0.0 6.1e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 VDK85490.1 - 0.004 17.7 0.1 0.0059 17.1 0.1 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 VDK85490.1 - 0.0052 16.5 0.0 0.0084 15.8 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 VDK85490.1 - 0.0064 15.8 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Met-zincin Astacin PF01400.24 VDK85490.1 - 0.017 14.8 0.2 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_5 PF13688.6 VDK85490.1 - 0.018 15.2 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M57 PF12388.8 VDK85490.1 - 0.028 14.0 0.0 0.037 13.6 0.0 1.2 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M54 PF07998.11 VDK85490.1 - 0.11 12.5 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 Peptidase family M54 Metallopep PF12044.8 VDK85490.1 - 0.13 10.8 0.2 0.2 10.2 0.2 1.1 1 0 0 1 1 1 0 Putative peptidase family Gtr1_RagA PF04670.12 VDK85492.1 - 4.9e-64 215.9 2.0 6.8e-64 215.4 2.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 VDK85492.1 - 2.5e-05 23.8 0.0 4.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 VDK85492.1 - 0.0003 20.8 0.0 0.00061 19.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 VDK85492.1 - 0.009 15.5 0.0 0.015 14.8 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA PF00004.29 VDK85492.1 - 0.076 13.4 0.0 0.15 12.5 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 VDK85492.1 - 0.089 13.2 0.0 0.3 11.4 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 VDK85495.1 - 5.8e-66 222.6 0.0 6.6e-66 222.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85495.1 - 6.3e-32 110.9 0.0 7.9e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK85495.1 - 3.9e-05 22.8 0.1 0.00012 21.1 0.1 1.7 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 VDK85495.1 - 0.007 16.3 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 VDK85495.1 - 0.029 13.4 0.0 0.043 12.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 MCM PF00493.23 VDK85496.1 - 1.8e-99 331.4 0.0 3.1e-99 330.6 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 VDK85496.1 - 3.2e-33 114.3 1.0 5.4e-33 113.5 1.0 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 VDK85496.1 - 1.1e-22 80.2 0.6 2.6e-22 79.0 0.6 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 VDK85496.1 - 1.8e-16 60.6 2.0 2.9e-16 59.9 1.1 1.9 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 VDK85496.1 - 9.3e-08 31.7 0.0 7.4e-06 25.5 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 VDK85496.1 - 1.3e-06 28.5 0.0 6.2e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 VDK85496.1 - 0.0073 16.2 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 VDK85496.1 - 0.0089 15.8 0.0 0.053 13.2 0.0 2.0 2 0 0 2 2 2 1 Sigma-54 interaction domain HP1451_C PF18472.1 VDK85496.1 - 0.13 12.2 0.3 4.5 7.3 0.1 3.1 2 1 0 2 2 2 0 HP1451 C-terminal domain RhoGAP PF00620.27 VDK85512.1 - 1.1e-19 70.8 0.0 1.7e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain C5-epim_C PF06662.13 VDK85514.1 - 5.3e-69 231.5 0.1 9.2e-69 230.7 0.1 1.4 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus HD_6 PF18019.1 VDK85514.1 - 0.0087 16.2 0.2 0.032 14.4 0.0 1.9 2 0 0 2 2 2 1 HD domain DUF5348 PF17295.2 VDK85514.1 - 0.15 12.0 0.2 1.3 9.0 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5348) FRD2 PF03197.13 VDK85514.1 - 0.22 11.8 2.1 2.6 8.4 0.5 2.5 2 0 0 2 2 2 0 Bacteriophage FRD2 protein Neur_chan_LBD PF02931.23 VDK85515.1 - 2.1e-17 63.3 0.1 1.1e-16 60.9 0.1 1.9 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel ligand binding domain Ig_3 PF13927.6 VDK85519.1 - 1.3e-61 205.2 14.2 3.2e-10 40.5 0.4 7.2 6 0 0 6 6 6 6 Immunoglobulin domain Ig_2 PF13895.6 VDK85519.1 - 4.5e-53 177.5 10.4 1.6e-09 38.0 0.3 7.2 6 1 0 6 6 6 6 Immunoglobulin domain I-set PF07679.16 VDK85519.1 - 9.5e-45 150.6 5.6 3.7e-11 42.9 0.0 8.6 7 3 0 7 7 7 7 Immunoglobulin I-set domain ig PF00047.25 VDK85519.1 - 1.9e-33 114.5 9.6 4.7e-07 29.9 0.0 8.5 7 3 0 7 7 7 6 Immunoglobulin domain C2-set_2 PF08205.12 VDK85519.1 - 9.4e-13 48.1 5.2 0.00031 20.8 0.1 5.6 6 0 0 6 6 6 3 CD80-like C2-set immunoglobulin domain V-set PF07686.17 VDK85519.1 - 2e-10 40.8 17.7 0.11 12.7 0.1 9.7 7 5 2 9 9 9 4 Immunoglobulin V-set domain C1-set PF07654.15 VDK85519.1 - 1.5e-08 34.9 2.7 0.065 13.6 0.2 6.2 6 0 0 6 6 6 2 Immunoglobulin C1-set domain Ig_5 PF16681.5 VDK85519.1 - 1.6e-07 31.6 3.0 1.5 9.3 0.1 7.1 7 1 0 7 7 7 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain fn3 PF00041.21 VDK85519.1 - 2.9e-06 27.5 0.1 6.9e-05 23.1 0.1 2.8 1 1 0 1 1 1 1 Fibronectin type III domain Ig_6 PF18452.1 VDK85519.1 - 0.0011 18.5 4.1 0.37 10.4 0.0 4.4 5 1 1 6 6 6 1 Immunoglobulin domain V-set_CD47 PF08204.11 VDK85519.1 - 0.0022 17.9 2.2 21 5.1 0.1 4.3 4 0 0 4 4 4 0 CD47 immunoglobulin-like domain DnaJ PF00226.31 VDK85524.1 - 1.4e-26 92.4 0.4 2.2e-26 91.8 0.4 1.3 1 0 0 1 1 1 1 DnaJ domain FPL PF09758.9 VDK85525.1 - 7.1e-59 198.1 11.8 1.5e-58 197.1 11.8 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein RIX1 PF08167.12 VDK85525.1 - 0.0036 17.1 0.1 0.94 9.2 0.0 2.5 2 1 0 2 2 2 2 rRNA processing/ribosome biogenesis Herpes_heli_pri PF05774.11 VDK85525.1 - 0.054 13.7 1.6 1.4 9.2 0.1 2.5 2 0 0 2 2 2 0 Herpesvirus helicase-primase complex component zf-C3HC4_3 PF13920.6 VDK85527.1 - 9e-09 35.1 12.9 9e-09 35.1 12.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 VDK85531.1 - 2.5e-38 132.0 0.0 6.2e-38 130.7 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85531.1 - 2.8e-24 85.8 0.0 6.5e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Adaptin_N PF01602.20 VDK85535.1 - 6.9e-136 453.9 9.8 7.9e-136 453.7 9.8 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 VDK85535.1 - 3.2e-10 40.3 9.6 5.3e-08 33.1 0.9 2.9 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Myb_DNA-bind_7 PF15963.5 VDK85536.1 - 5.3e-22 77.5 0.1 4.4e-21 74.6 0.0 2.6 2 1 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 VDK85536.1 - 0.0049 17.0 0.0 0.016 15.4 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Calponin PF00402.18 VDK85537.1 - 1.8e-22 78.6 2.6 6.2e-12 44.9 0.0 2.2 2 0 0 2 2 2 2 Calponin family repeat Calponin PF00402.18 VDK85539.1 - 3.5e-70 231.2 42.7 1.2e-11 44.1 0.7 7.2 7 0 0 7 7 7 7 Calponin family repeat YicC_N PF03755.13 VDK85539.1 - 4.1 7.9 9.1 1.3e+02 3.0 0.1 5.3 6 0 0 6 6 6 0 YicC-like family, N-terminal region IFN-gamma PF00714.17 VDK85543.1 - 0.011 15.5 0.1 0.025 14.4 0.1 1.5 1 0 0 1 1 1 0 Interferon gamma Globin PF00042.22 VDK85543.1 - 0.019 15.6 0.0 0.034 14.7 0.0 1.4 1 0 0 1 1 1 0 Globin Protoglobin PF11563.8 VDK85543.1 - 0.036 14.0 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Protoglobin Metal_resist PF13801.6 VDK85543.1 - 0.062 13.5 2.0 0.23 11.7 0.4 2.5 2 1 1 3 3 3 0 Heavy-metal resistance CARD_2 PF16739.5 VDK85543.1 - 0.077 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Caspase recruitment domain RRM_1 PF00076.22 VDK85544.1 - 1.6e-16 59.9 0.3 3e-15 55.8 0.0 2.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BolA PF01722.18 VDK85545.1 - 4.7e-20 71.7 0.1 1.6e-19 70.0 0.1 1.8 1 1 0 1 1 1 1 BolA-like protein Ank_5 PF13857.6 VDK85546.1 - 1.9e-19 69.4 0.1 1.9e-13 50.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK85546.1 - 3.2e-16 59.7 0.0 6.7e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 VDK85546.1 - 9.5e-16 57.5 0.0 2.1e-06 27.9 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat ACBP PF00887.19 VDK85546.1 - 3.1e-15 56.2 0.0 5.9e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein Ank_3 PF13606.6 VDK85546.1 - 5.6e-15 54.0 0.0 1.9e-06 27.7 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 VDK85546.1 - 9.6e-15 54.8 0.0 2.3e-14 53.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) OST3_OST6 PF04756.13 VDK85548.1 - 4.7e-101 338.0 0.8 5.8e-101 337.7 0.8 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Yip1 PF04893.17 VDK85548.1 - 9.8e-05 22.1 7.4 0.00074 19.3 7.4 2.1 1 1 0 1 1 1 1 Yip1 domain DUF4131 PF13567.6 VDK85548.1 - 0.00028 20.6 4.5 0.0029 17.3 0.7 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4131) HisKA_7TM PF16927.5 VDK85548.1 - 0.00037 20.6 5.3 0.00037 20.6 5.3 1.5 2 0 0 2 2 2 1 N-terminal 7TM region of histidine kinase Thioredoxin PF00085.20 VDK85548.1 - 0.0081 16.1 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin DUF3382 PF11862.8 VDK85548.1 - 0.0098 16.2 7.7 0.2 11.9 2.8 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF3382) DUF998 PF06197.13 VDK85548.1 - 1.4 8.5 7.4 7.1 6.2 7.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF998) DUF3098 PF11297.8 VDK85548.1 - 9.1 6.0 11.5 5.4 6.7 0.0 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF3098) zf-C2H2_jaz PF12171.8 VDK85549.1 - 5e-07 29.8 0.7 9.5e-07 28.9 0.7 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK85549.1 - 2.3e-05 24.6 0.7 4.3e-05 23.7 0.7 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 VDK85549.1 - 5.8e-05 22.8 1.6 0.00012 21.8 1.6 1.5 1 0 0 1 1 1 1 U1 zinc finger SNRNP27 PF08648.12 VDK85549.1 - 0.0025 17.9 1.8 0.0059 16.6 0.2 2.6 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins PDGLE PF13190.6 VDK85549.1 - 0.015 15.2 0.1 0.033 14.1 0.1 1.6 1 0 0 1 1 1 0 PDGLE domain zf-C2H2 PF00096.26 VDK85549.1 - 0.2 12.2 0.6 0.44 11.1 0.6 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type RIBIOP_C PF04950.12 VDK85549.1 - 0.73 9.2 8.4 0.65 9.4 3.4 2.2 2 0 0 2 2 2 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal ORC5_C PF14630.6 VDK85549.1 - 0.83 9.1 4.9 0.2 11.1 0.3 1.9 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus Mitoc_L55 PF09776.9 VDK85549.1 - 6.4 6.6 14.7 1.5 8.6 1.5 3.8 3 1 1 4 4 4 0 Mitochondrial ribosomal protein L55 LRR_8 PF13855.6 VDK85550.1 - 2.3e-21 75.3 20.2 4.2e-09 36.0 7.1 3.8 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 VDK85550.1 - 7.4e-19 67.5 19.7 8.3e-08 32.4 3.9 4.6 3 2 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK85550.1 - 1.4e-11 43.2 16.9 1.6 9.6 0.7 8.1 8 0 0 8 8 8 5 Leucine Rich Repeat LRR_6 PF13516.6 VDK85550.1 - 0.00024 20.9 21.9 2.9 8.2 0.1 7.1 7 0 0 7 7 7 2 Leucine Rich repeat NKWYS PF10364.9 VDK85550.1 - 0.01 16.0 0.8 1 9.5 0.1 2.5 2 1 1 3 3 3 1 Putative capsular polysaccharide synthesis protein Tubulin PF00091.25 VDK85551.1 - 9.5e-68 228.3 0.0 1.3e-67 227.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK85551.1 - 5.5e-42 142.9 0.0 9e-42 142.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDK85551.1 - 0.003 17.3 0.0 0.0048 16.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain MSP PF01716.18 VDK85551.1 - 0.18 11.0 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 Manganese-stabilising protein / photosystem II polypeptide RasGEF_N PF00618.20 VDK85555.1 - 0.028 14.6 0.0 0.12 12.7 0.0 1.9 1 1 0 1 1 1 0 RasGEF N-terminal motif NT-C2 PF10358.9 VDK85556.1 - 6e-17 61.7 0.3 1.4e-16 60.5 0.1 1.7 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins CH PF00307.31 VDK85556.1 - 6.4e-15 55.3 0.0 1.9e-14 53.8 0.0 1.8 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK85556.1 - 3.9e-06 26.6 0.0 1.1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain DUF3585 PF12130.8 VDK85556.1 - 0.00023 21.3 3.9 0.00023 21.3 3.9 2.5 2 0 0 2 2 2 1 Bivalent Mical/EHBP Rab binding domain MADF_DNA_bdg PF10545.9 VDK85561.1 - 0.00034 20.9 4.4 0.00048 20.4 2.8 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like ACBP PF00887.19 VDK85563.1 - 2.8e-08 33.9 0.0 3.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein Pkinase PF00069.25 VDK85564.1 - 3.6e-16 59.3 0.0 1.1e-15 57.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85564.1 - 7.8e-11 41.7 0.0 3.8e-10 39.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 VDK85564.1 - 3.5e-07 30.8 9.9 0.00029 21.6 0.0 5.5 4 1 0 4 4 4 1 WD domain, G-beta repeat HEAT PF02985.22 VDK85564.1 - 5.4e-05 23.1 3.4 1.9 9.0 0.0 6.2 6 0 0 6 6 6 1 HEAT repeat ANAPC4_WD40 PF12894.7 VDK85564.1 - 0.006 16.8 0.0 5.3 7.4 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Adaptin_N PF01602.20 VDK85564.1 - 0.0096 14.5 3.3 0.033 12.8 3.3 1.9 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 VDK85564.1 - 0.011 15.7 2.7 11 6.1 0.1 3.6 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 VDK85564.1 - 0.021 14.3 2.7 0.14 11.6 0.2 2.4 2 0 0 2 2 2 0 Armadillo-like Xpo1 PF08389.12 VDK85564.1 - 0.082 13.0 0.8 2.3 8.3 0.1 2.9 2 0 0 2 2 2 0 Exportin 1-like protein Myosin_head PF00063.21 VDK85573.1 - 1.4e-224 747.3 0.8 1.4e-224 747.3 0.8 2.2 2 1 0 2 2 2 1 Myosin head (motor domain) DUF3439 PF11921.8 VDK85573.1 - 0.0029 17.6 3.8 0.0029 17.6 3.8 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) APG6_N PF17675.1 VDK85573.1 - 0.0074 16.8 15.4 0.0074 16.8 15.4 6.2 3 2 2 5 5 5 2 Apg6 coiled-coil region AAA_16 PF13191.6 VDK85573.1 - 0.078 13.4 0.0 0.078 13.4 0.0 3.0 4 0 0 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 VDK85573.1 - 0.14 12.4 0.1 0.14 12.4 0.1 4.2 3 1 0 3 3 3 0 AAA domain TFA2_Winged_2 PF18121.1 VDK85573.1 - 1.2 8.9 4.6 0.79 9.5 0.7 2.8 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 Mucin PF01456.17 VDK85573.1 - 1.9 8.5 25.9 3.7 7.5 25.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Nup35_RRM PF05172.13 VDK85574.1 - 2.6e-17 62.6 0.0 1e-16 60.8 0.0 2.0 1 1 1 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 VDK85574.1 - 7.5e-11 41.9 0.0 1.5e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Cytochrom_C PF00034.21 VDK85574.1 - 7.7e-09 36.6 0.0 2.9e-08 34.7 0.0 2.0 2 1 1 3 3 3 1 Cytochrome c Cytochrome_CBB3 PF13442.6 VDK85574.1 - 0.0026 18.0 0.0 0.0082 16.4 0.0 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 VDK85574.1 - 0.0081 15.9 0.0 0.026 14.2 0.0 1.8 1 0 0 1 1 1 1 Cytochrome c-550 domain AAA PF00004.29 VDK85575.1 - 3.8e-42 143.9 0.0 8e-42 142.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK85575.1 - 2.9e-10 39.8 0.0 8.2e-10 38.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 VDK85575.1 - 4.6e-06 26.8 0.0 1.2e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 VDK85575.1 - 3.4e-05 23.6 0.0 6.2e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 VDK85575.1 - 4.5e-05 23.9 0.5 0.00023 21.6 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 VDK85575.1 - 0.00022 21.5 0.3 0.012 15.9 0.3 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 VDK85575.1 - 0.00048 20.1 0.0 0.0014 18.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 VDK85575.1 - 0.0028 16.9 0.0 0.011 15.0 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 VDK85575.1 - 0.01 16.2 0.0 0.042 14.3 0.0 2.1 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 VDK85575.1 - 0.01 15.8 0.0 0.3 11.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 VDK85575.1 - 0.011 15.8 0.3 0.035 14.1 0.0 2.0 3 0 0 3 3 1 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 VDK85575.1 - 0.011 16.3 0.0 0.04 14.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 VDK85575.1 - 0.014 15.5 0.0 0.03 14.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 VDK85575.1 - 0.016 14.8 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region KTI12 PF08433.10 VDK85575.1 - 0.016 14.7 3.1 1.5 8.2 0.0 3.1 3 0 0 3 3 3 0 Chromatin associated protein KTI12 Mg_chelatase PF01078.21 VDK85575.1 - 0.018 14.4 0.2 0.052 12.9 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 VDK85575.1 - 0.018 14.3 0.6 0.069 12.4 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) RuvB_N PF05496.12 VDK85575.1 - 0.024 14.4 0.0 0.067 12.9 0.0 1.7 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 VDK85575.1 - 0.032 13.8 0.0 0.069 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 VDK85575.1 - 0.037 13.8 5.5 0.38 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 VDK85575.1 - 0.038 13.1 0.0 0.079 12.0 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 VDK85575.1 - 0.062 13.0 0.0 0.19 11.4 0.0 1.8 1 1 1 2 2 2 0 Sigma-54 interaction domain AAA_33 PF13671.6 VDK85575.1 - 0.065 13.4 0.2 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 VDK85575.1 - 0.069 13.4 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 VDK85575.1 - 0.077 13.5 0.0 0.3 11.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter ATPase_2 PF01637.18 VDK85575.1 - 0.12 12.2 0.0 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea zf-LITAF-like PF10601.9 VDK85578.1 - 1.9e-21 76.1 16.8 2.4e-21 75.7 16.8 1.2 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain IFT20 PF14931.6 VDK85579.1 - 1e-31 109.6 5.1 1.1e-31 109.4 5.1 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 DUF641 PF04859.12 VDK85579.1 - 0.038 14.3 2.6 0.052 13.9 2.6 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) I_LWEQ PF01608.17 VDK85579.1 - 0.084 13.1 5.0 0.27 11.4 5.0 1.7 1 1 0 1 1 1 0 I/LWEQ domain Morc6_S5 PF17942.1 VDK85579.1 - 0.13 12.3 0.2 0.44 10.6 0.1 1.9 2 1 0 2 2 2 0 Morc6 ribosomal protein S5 domain 2-like DUF4200 PF13863.6 VDK85579.1 - 0.35 11.3 8.7 0.54 10.7 8.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Lustrin_cystein PF14625.6 VDK85580.1 - 0.0076 16.6 3.1 0.021 15.2 3.1 1.8 1 0 0 1 1 1 1 Lustrin, cysteine-rich repeated domain ChiC PF06483.11 VDK85581.1 - 0.051 13.5 2.0 0.091 12.7 2.0 1.5 1 0 0 1 1 1 0 Chitinase C Pkinase PF00069.25 VDK85582.1 - 1.3e-49 169.0 0.0 1.6e-49 168.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85582.1 - 3.7e-24 85.4 0.1 5.3e-24 84.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 VDK85582.1 - 0.0029 17.2 1.3 0.0057 16.3 0.8 1.7 1 1 1 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 VDK85582.1 - 0.058 13.3 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AMPK1_CBM PF16561.5 VDK85583.1 - 2.3e-06 27.7 0.0 6e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase ATG16 PF08614.11 VDK85583.1 - 0.014 15.6 0.1 0.014 15.6 0.1 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SlyX PF04102.12 VDK85583.1 - 0.036 14.7 4.2 8.7 7.0 0.4 3.2 3 0 0 3 3 3 0 SlyX Ntox28 PF15605.6 VDK85583.1 - 0.066 13.5 1.1 4.3 7.6 0.1 3.0 1 1 1 2 2 2 0 Bacterial toxin 28 ERM PF00769.19 VDK85583.1 - 0.55 10.0 16.0 0.99 9.2 15.8 1.3 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Spc7 PF08317.11 VDK85583.1 - 0.82 8.5 12.2 0.096 11.6 7.0 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4200 PF13863.6 VDK85583.1 - 1.7 9.0 15.6 3.9 7.9 9.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4472 PF14739.6 VDK85583.1 - 2.2 9.1 11.1 2.1 9.1 8.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) ZapB PF06005.12 VDK85583.1 - 2.9 8.4 19.7 0.74 10.3 4.6 2.5 1 1 1 2 2 2 0 Cell division protein ZapB ADIP PF11559.8 VDK85583.1 - 3.2 7.8 15.1 0.29 11.2 10.0 1.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 VDK85583.1 - 4.3 7.3 17.3 9.8 6.2 12.7 2.1 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IgGFc_binding PF17517.2 VDK85584.1 - 4.9e-05 22.8 3.1 0.0004 19.8 0.4 2.6 2 1 0 2 2 2 1 IgGFc binding protein DUF961 PF06125.11 VDK85584.1 - 0.11 12.8 0.1 7.4 7.0 0.0 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF961) zf-BED PF02892.15 VDK85585.1 - 0.00011 22.1 0.1 0.00031 20.7 0.1 1.8 1 0 0 1 1 1 1 BED zinc finger OGG_N PF07934.12 VDK85586.1 - 4.5e-17 62.3 0.0 4.1e-16 59.2 0.0 2.1 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain DUF3579 PF12112.8 VDK85587.1 - 0.13 12.9 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3579) HMG_box PF00505.19 VDK85588.1 - 2.7e-13 50.1 0.9 5e-13 49.3 0.9 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK85588.1 - 3.4e-10 40.4 4.8 5.9e-10 39.6 4.8 1.4 1 0 0 1 1 1 1 HMG-box domain zf-C2H2_aberr PF17017.5 VDK85588.1 - 0.00012 22.2 3.5 0.00012 22.2 3.5 1.5 2 0 0 2 2 2 1 Aberrant zinc-finger Protamine_like PF06382.11 VDK85588.1 - 0.017 15.3 0.2 0.031 14.5 0.2 1.4 1 0 0 1 1 1 0 Protamine and protamine like DUF1059 PF06348.11 VDK85588.1 - 0.054 13.7 0.0 7.2 6.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1059) FOXP-CC PF16159.5 VDK85588.1 - 0.076 13.7 3.2 0.13 12.9 0.7 2.3 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 VDK85588.1 - 0.21 12.1 3.8 6.1 7.5 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 VDK85588.1 - 1.7 8.5 4.2 3.6 7.4 0.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DcpS PF05652.12 VDK85589.1 - 8.7e-17 61.9 0.0 1.5e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C PF11969.8 VDK85589.1 - 2.7e-06 27.8 0.0 5.6e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding GNT-I PF03071.15 VDK85590.1 - 6.3e-114 381.1 0.0 8.6e-114 380.6 0.0 1.1 1 0 0 1 1 1 1 GNT-I family PND PF17949.1 VDK85590.1 - 0.078 13.2 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 FANCM pseudonuclease domain Defensin_beta_2 PF13841.6 VDK85591.1 - 0.027 15.0 1.7 0.054 14.0 1.7 1.5 1 0 0 1 1 1 0 Beta defensin Pkinase PF00069.25 VDK85592.1 - 1.2e-19 70.7 0.1 1.4e-19 70.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85592.1 - 2.5e-09 36.8 0.0 2.8e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK85592.1 - 0.0012 18.8 0.0 0.15 11.9 0.0 2.1 1 1 0 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 VDK85592.1 - 0.0015 17.4 0.0 0.002 17.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK85592.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UCH PF00443.29 VDK85593.1 - 9.3e-47 159.7 0.2 1.3e-46 159.2 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 VDK85593.1 - 2.2e-21 76.2 0.1 3.5e-10 40.4 0.0 3.4 3 0 0 3 3 3 2 DUSP domain UCH_1 PF13423.6 VDK85593.1 - 1.8e-16 60.6 0.4 1.3e-12 47.9 0.1 2.6 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Mu-like_Com PF10122.9 VDK85593.1 - 0.069 12.6 0.2 0.2 11.1 0.0 1.9 2 0 0 2 2 2 0 Mu-like prophage protein Com Cnd1 PF12717.7 VDK85594.1 - 7.4e-25 87.9 10.4 1e-16 61.4 0.4 4.8 3 1 1 4 4 4 4 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 VDK85594.1 - 6.4e-11 41.5 19.8 0.052 13.8 0.1 8.5 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 VDK85594.1 - 7.9e-08 32.6 6.4 0.3 11.5 0.2 5.2 5 0 0 5 5 5 3 HEAT repeats Cnd3 PF12719.7 VDK85594.1 - 3.1e-06 26.6 4.7 6.5e-06 25.6 0.7 3.1 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 VDK85594.1 - 0.00097 18.8 2.4 5 6.6 0.0 4.1 2 2 1 3 3 3 1 CLASP N terminal HEAT_EZ PF13513.6 VDK85594.1 - 0.0046 17.4 6.5 2.1 9.0 0.1 5.6 5 1 0 5 5 5 1 HEAT-like repeat Uricase PF01014.18 VDK85594.1 - 0.0056 16.9 0.1 0.67 10.2 0.0 2.6 2 0 0 2 2 2 1 Uricase RTP1_C1 PF10363.9 VDK85594.1 - 0.0095 16.1 2.0 13 6.0 0.0 4.4 3 1 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 SASP PF00269.20 VDK85594.1 - 0.057 13.4 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Small, acid-soluble spore proteins, alpha/beta type Cohesin_HEAT PF12765.7 VDK85594.1 - 3 8.2 4.9 3.9 7.9 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion UBN_AB PF14075.6 VDK85595.1 - 0.82 9.4 4.2 1.2 8.8 2.0 2.1 1 1 1 2 2 2 0 Ubinuclein conserved middle domain EF_assoc_2 PF08356.12 VDK85597.1 - 1.6e-29 101.7 0.0 5.6e-29 100.0 0.0 2.0 2 0 0 2 2 1 1 EF hand associated Ras PF00071.22 VDK85597.1 - 8.3e-25 87.3 0.0 5.6e-18 65.1 0.0 2.9 2 1 0 2 2 2 2 Ras family EF_assoc_1 PF08355.12 VDK85597.1 - 9.5e-22 76.4 0.1 7.8e-21 73.5 0.2 2.2 2 0 0 2 2 2 1 EF hand associated Roc PF08477.13 VDK85597.1 - 4.9e-14 52.6 0.0 5.9e-10 39.4 0.0 3.0 3 1 0 3 3 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_6 PF13405.6 VDK85597.1 - 7e-09 34.9 1.9 0.00057 19.6 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 VDK85597.1 - 2.8e-08 32.7 1.2 0.0012 18.2 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 VDK85597.1 - 2.2e-07 31.3 0.3 9.5e-06 26.0 0.8 2.9 2 1 0 2 2 2 1 EF-hand domain pair PduV-EutP PF10662.9 VDK85597.1 - 1.3e-05 24.9 2.2 0.11 12.3 0.3 4.1 2 2 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 VDK85597.1 - 2.5e-05 23.8 0.1 0.00013 21.4 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 VDK85597.1 - 4.7e-05 23.3 0.2 0.1 12.4 0.0 3.6 3 1 1 4 4 4 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 VDK85597.1 - 5.2e-05 23.7 0.0 0.011 16.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 VDK85597.1 - 6e-05 23.5 0.3 0.088 13.2 0.0 3.4 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Arf PF00025.21 VDK85597.1 - 6.8e-05 22.4 0.0 0.00077 19.0 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 VDK85597.1 - 0.00012 22.1 3.3 0.75 9.7 0.0 5.0 4 1 2 6 6 5 1 RsgA GTPase AAA_22 PF13401.6 VDK85597.1 - 0.00015 22.0 0.1 0.3 11.3 0.0 3.1 2 2 0 2 2 2 1 AAA domain AAA_24 PF13479.6 VDK85597.1 - 0.00018 21.3 0.0 0.11 12.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 VDK85597.1 - 0.00022 21.2 0.0 0.47 10.3 0.0 2.4 2 0 0 2 2 2 2 NACHT domain EF-hand_8 PF13833.6 VDK85597.1 - 0.00035 20.4 0.3 0.86 9.5 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain pair AAA_5 PF07728.14 VDK85597.1 - 0.00037 20.5 0.0 0.016 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.23 VDK85597.1 - 0.001 19.1 0.1 0.077 13.1 0.0 3.1 2 2 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 VDK85597.1 - 0.0012 19.4 0.0 1.9 9.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_28 PF13521.6 VDK85597.1 - 0.0014 18.9 0.0 0.26 11.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain Septin PF00735.18 VDK85597.1 - 0.0016 17.8 0.0 0.22 10.8 0.0 2.3 2 0 0 2 2 2 1 Septin AAA_7 PF12775.7 VDK85597.1 - 0.0027 17.2 0.0 0.38 10.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Pox_A32 PF04665.12 VDK85597.1 - 0.0041 16.6 0.1 2.6 7.5 0.0 2.9 3 1 0 3 3 2 1 Poxvirus A32 protein AAA_33 PF13671.6 VDK85597.1 - 0.005 17.0 0.0 4.5 7.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain SPARC_Ca_bdg PF10591.9 VDK85597.1 - 0.0055 17.0 0.0 1.4 9.3 0.0 2.4 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TsaE PF02367.17 VDK85597.1 - 0.021 14.8 0.0 9 6.3 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EF-hand_5 PF13202.6 VDK85597.1 - 0.024 14.1 7.0 0.046 13.2 0.0 2.8 3 0 0 3 3 2 0 EF hand RNA_helicase PF00910.22 VDK85597.1 - 0.027 14.8 0.0 5.1 7.5 0.0 2.7 2 0 0 2 2 2 0 RNA helicase EF-hand_10 PF14788.6 VDK85597.1 - 0.029 14.2 1.1 0.73 9.7 0.2 2.5 2 0 0 2 2 2 0 EF hand AAA_14 PF13173.6 VDK85597.1 - 0.049 13.7 0.0 2 8.5 0.0 2.8 2 2 0 2 2 2 0 AAA domain AAA_25 PF13481.6 VDK85597.1 - 0.059 12.9 0.0 1.8 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 VDK85597.1 - 0.069 12.9 0.0 4 7.2 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain MCM PF00493.23 VDK85597.1 - 0.088 11.9 0.0 0.36 9.9 0.0 1.9 2 0 0 2 2 2 0 MCM P-loop domain RuvB_N PF05496.12 VDK85597.1 - 0.089 12.5 0.0 2.2 8.0 0.0 2.7 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 VDK85597.1 - 0.092 12.5 0.0 8.5 6.1 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein ATPase PF06745.13 VDK85597.1 - 0.099 12.0 0.1 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.6 VDK85597.1 - 0.2 12.2 0.0 2.6 8.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 VDK85597.1 - 0.2 12.0 0.2 3.3 8.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain Alpha_kinase PF02816.18 VDK85598.1 - 8.2e-39 133.6 0.6 2.2e-38 132.2 0.1 1.8 2 0 0 2 2 2 1 Alpha-kinase family TetR_C_10 PF16295.5 VDK85598.1 - 0.015 15.5 1.6 0.06 13.6 0.2 2.3 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Sel1 PF08238.12 VDK85599.1 - 0.11 13.2 0.2 21 5.9 0.0 3.2 3 0 0 3 3 3 0 Sel1 repeat Sel1 PF08238.12 VDK85603.1 - 0.11 13.2 0.2 21 5.9 0.0 3.2 3 0 0 3 3 3 0 Sel1 repeat V-SNARE_C PF12352.8 VDK85609.1 - 2.3e-06 27.8 11.4 6.7e-05 23.1 4.1 2.5 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus DUF5089 PF17002.5 VDK85609.1 - 0.00065 19.6 9.7 0.05 13.5 0.3 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF5089) DUF745 PF05335.13 VDK85609.1 - 0.0059 16.3 5.1 0.043 13.6 0.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF745) LPP PF04728.13 VDK85609.1 - 0.013 15.9 2.5 0.033 14.6 2.5 1.8 1 0 0 1 1 1 0 Lipoprotein leucine-zipper DUF1664 PF07889.12 VDK85609.1 - 0.025 14.6 6.3 0.68 10.0 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2584 PF10763.9 VDK85609.1 - 0.042 14.0 0.0 0.13 12.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2584) FliD_C PF07195.12 VDK85609.1 - 0.042 13.3 6.0 0.061 12.7 6.0 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus CREPT PF16566.5 VDK85609.1 - 0.071 13.3 5.0 1.8 8.7 1.0 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour EMP24_GP25L PF01105.24 VDK85609.1 - 0.1 12.5 0.1 0.1 12.5 0.1 2.4 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Spc7 PF08317.11 VDK85609.1 - 0.47 9.3 12.4 1.6 7.5 4.5 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Sec2p PF06428.11 VDK85609.1 - 0.51 10.3 9.5 1.1 9.3 0.4 3.4 2 2 1 3 3 3 0 GDP/GTP exchange factor Sec2p DUF3053 PF11254.8 VDK85609.1 - 0.8 9.2 7.8 0.26 10.8 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3053) UPF0242 PF06785.11 VDK85609.1 - 1.3 9.1 8.9 0.87 9.7 0.6 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Vps53_N PF04100.12 VDK85609.1 - 1.8 7.4 7.6 3.7 6.4 1.6 2.1 2 0 0 2 2 2 0 Vps53-like, N-terminal DUF724 PF05266.14 VDK85609.1 - 2.7 7.8 7.4 3.4 7.5 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Laminin_II PF06009.12 VDK85609.1 - 3.2 7.8 9.8 5.1 7.1 1.3 2.9 2 2 0 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 VDK85609.1 - 4.3 7.7 9.5 1.5 9.2 0.4 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMPIT PF07851.13 VDK85609.1 - 8.3 5.5 7.6 7.4 5.7 0.8 2.0 2 0 0 2 2 2 0 TMPIT-like protein Ground-like PF04155.18 VDK85610.1 - 8.9e-19 67.9 0.7 8.9e-19 67.9 0.7 1.7 2 0 0 2 2 2 1 Ground-like domain FERM_M PF00373.18 VDK85610.1 - 0.069 13.6 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 FERM central domain AdoHcyase_NAD PF00670.21 VDK85610.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain PRONE PF03759.13 VDK85611.1 - 0.0077 15.1 5.8 0.0077 15.1 5.8 1.6 2 1 0 2 2 2 1 PRONE (Plant-specific Rop nucleotide exchanger) DUF2347 PF09804.9 VDK85611.1 - 0.27 10.8 8.2 0.1 12.2 3.7 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2347) ArAE_1_C PF11728.8 VDK85611.1 - 0.53 10.3 13.4 0.078 13.0 1.7 2.4 1 1 2 3 3 3 0 Putative aromatic acid exporter C-terminal domain DUF5398 PF17376.2 VDK85611.1 - 0.75 10.5 0.1 0.75 10.5 0.1 2.7 2 1 2 4 4 4 0 Family of unknown function (DUF5398) Ku_C PF03730.14 VDK85611.1 - 6.6 7.5 8.3 5.6 7.7 2.7 2.9 2 1 1 3 3 3 0 Ku70/Ku80 C-terminal arm DNA_pol_E_B PF04042.16 VDK85612.1 - 6.3e-34 117.2 0.0 1.4e-33 116.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B ATG101 PF07855.12 VDK85612.1 - 1.3e-22 80.4 3.1 1.1e-21 77.5 1.0 2.9 2 1 0 2 2 2 1 Autophagy-related protein 101 R3H PF01424.22 VDK85612.1 - 0.12 12.4 0.7 0.42 10.6 0.0 2.2 2 0 0 2 2 2 0 R3H domain DRY_EERY PF09750.9 VDK85613.1 - 9.6e-20 71.2 1.9 9.6e-20 71.2 1.9 4.2 5 1 0 5 5 5 1 Alternative splicing regulator Surp PF01805.20 VDK85613.1 - 7.5e-18 64.3 3.9 1.3e-11 44.3 0.1 3.1 3 0 0 3 3 3 2 Surp module IRF-2BP1_2 PF11261.8 VDK85623.1 - 9.6e-33 111.5 3.3 9.6e-33 111.5 3.3 2.0 2 0 0 2 2 2 1 Interferon regulatory factor 2-binding protein zinc finger zf-C3HC4 PF00097.25 VDK85623.1 - 0.0015 18.4 8.1 0.0046 16.8 8.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 VDK85623.1 - 1.2 9.1 7.6 0.055 13.4 0.8 2.0 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_2 PF13923.6 VDK85623.1 - 1.4 8.8 13.2 0.11 12.4 7.8 2.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 VDK85623.1 - 6 7.1 13.0 0.22 11.7 5.3 2.5 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 VDK85623.1 - 6.6 6.7 16.3 0.042 13.7 6.3 2.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Tyr_Deacylase PF02580.16 VDK85624.1 - 6e-42 143.6 0.0 6.8e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase rve PF00665.26 VDK85625.1 - 6.9e-05 23.0 0.0 0.00016 21.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DUF1180 PF06679.12 VDK85631.1 - 2.1 8.7 11.1 0.23 11.9 4.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) 7tm_2 PF00002.24 VDK85632.1 - 2e-52 177.9 19.0 2.8e-52 177.5 19.0 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) GAIN PF16489.5 VDK85632.1 - 2.2e-21 76.3 0.6 3.1e-21 75.8 0.6 1.2 1 0 0 1 1 1 1 GPCR-Autoproteolysis INducing (GAIN) domain Gal_Lectin PF02140.18 VDK85632.1 - 6.5e-15 55.3 6.2 6e-08 33.0 0.4 2.9 3 0 0 3 3 3 2 Galactose binding lectin domain GPS PF01825.21 VDK85632.1 - 1.8e-14 54.0 9.7 5.2e-14 52.5 9.7 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif HRM PF02793.22 VDK85632.1 - 2e-05 24.8 2.3 4.8e-05 23.6 2.3 1.7 1 0 0 1 1 1 1 Hormone receptor domain IL4Ra_N PF09238.10 VDK85632.1 - 0.058 13.7 0.3 0.16 12.3 0.3 1.7 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal DUF21 PF01595.20 VDK85641.1 - 1.3e-32 113.0 2.5 2.5e-32 112.0 2.5 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 VDK85641.1 - 1.1e-07 32.1 1.0 0.025 15.0 0.0 2.7 2 0 0 2 2 2 2 CBS domain UL141 PF16758.5 VDK85642.1 - 0.045 13.5 0.0 0.074 12.8 0.0 1.4 1 0 0 1 1 1 0 Herpes-like virus membrane glycoprotein UL141 Inositol_P PF00459.25 VDK85644.1 - 2.1e-40 138.9 0.2 6.7e-40 137.3 0.2 1.6 1 1 0 1 1 1 1 Inositol monophosphatase family Phospholip_A2_2 PF05826.12 VDK85644.1 - 0.033 14.4 0.1 0.12 12.6 0.1 1.9 1 0 0 1 1 1 0 Phospholipase A2 RRM_1 PF00076.22 VDK85645.1 - 0.066 13.0 0.0 0.47 10.3 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RINGv PF12906.7 VDK85646.1 - 8.2e-16 57.9 10.5 1.3e-15 57.2 10.5 1.3 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 VDK85646.1 - 0.0033 17.7 10.1 0.0066 16.8 10.1 1.5 1 0 0 1 1 1 1 Ring finger domain DUF587 PF04532.12 VDK85646.1 - 0.039 13.2 0.5 0.053 12.8 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF587) zf-RING_4 PF14570.6 VDK85646.1 - 0.067 13.0 4.5 0.16 11.8 4.5 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 VDK85646.1 - 0.16 12.1 8.4 1.4 9.2 8.4 2.1 1 1 1 2 2 2 0 FANCL C-terminal domain zf-C3HC4 PF00097.25 VDK85646.1 - 0.87 9.5 6.8 7.9 6.4 7.1 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Globin PF00042.22 VDK85650.1 - 5e-09 36.7 0.2 8.4e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 Globin WD40 PF00400.32 VDK85651.1 - 7.3e-49 162.7 31.4 8.1e-09 36.0 0.3 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK85651.1 - 9.6e-13 48.3 6.7 0.077 13.3 0.2 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 VDK85651.1 - 3e-12 46.2 0.3 7.2e-12 45.0 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 VDK85651.1 - 2.1e-09 37.0 0.4 4.4e-09 36.0 0.4 1.6 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 VDK85651.1 - 9.3e-08 31.2 14.2 0.14 10.8 0.2 6.0 2 2 4 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 VDK85651.1 - 1.3e-07 31.0 10.7 0.042 12.8 0.2 5.3 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 VDK85651.1 - 0.0089 15.4 0.1 0.23 10.7 0.0 2.7 2 1 0 3 3 3 1 WD40-like domain DDE_Tnp_4 PF13359.6 VDK85651.1 - 0.033 13.9 0.1 0.58 9.8 0.0 2.3 2 0 0 2 2 2 0 DDE superfamily endonuclease MPP6 PF10175.9 VDK85651.1 - 0.036 14.6 2.5 0.063 13.8 2.5 1.3 1 0 0 1 1 1 0 M-phase phosphoprotein 6 SMN PF06003.12 VDK85651.1 - 0.21 10.8 2.4 0.39 9.9 2.4 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) FAM176 PF14851.6 VDK85651.1 - 2.9 7.5 5.6 6.5 6.4 5.6 1.5 1 0 0 1 1 1 0 FAM176 family Rhodanese PF00581.20 VDK85652.1 - 1.8e-09 38.1 0.0 4.6e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain DUF4315 PF14193.6 VDK85653.1 - 0.0062 16.5 3.7 0.02 14.9 3.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4315) UvrA_inter PF17760.1 VDK85653.1 - 0.014 15.5 0.8 0.014 15.5 0.8 1.9 2 0 0 2 2 2 0 UvrA interaction domain TLE_N PF03920.15 VDK85653.1 - 0.02 15.0 2.1 0.046 13.8 2.1 1.6 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain DUF2935 PF11155.8 VDK85653.1 - 0.061 13.7 2.8 0.11 12.8 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) BNIP2 PF12496.8 VDK85653.1 - 0.66 10.4 7.4 0.34 11.3 0.3 2.7 2 1 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF16 PF01519.16 VDK85653.1 - 8.2 7.0 12.7 0.74 10.3 6.3 2.5 2 1 1 3 3 3 0 Protein of unknown function DUF16 Rhodanese PF00581.20 VDK85654.1 - 4.2e-14 53.0 0.2 2.2e-13 50.6 0.1 1.9 2 0 0 2 2 2 1 Rhodanese-like domain HLH PF00010.26 VDK85663.1 - 5.7e-15 55.0 5.0 9.9e-15 54.2 5.0 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Neuro_bHLH PF12533.8 VDK85663.1 - 1.1e-08 36.3 19.7 3.8e-08 34.6 19.7 2.0 1 1 0 1 1 1 1 Neuronal helix-loop-helix transcription factor Androgen_recep PF02166.16 VDK85663.1 - 0.028 13.3 7.8 0.034 13.0 7.8 1.2 1 0 0 1 1 1 0 Androgen receptor DUF5349 PF17298.2 VDK85663.1 - 0.033 13.9 18.1 0.067 13.0 18.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5349) TFIIA PF03153.13 VDK85663.1 - 0.18 11.8 21.0 0.22 11.5 21.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 VDK85663.1 - 0.71 8.6 3.2 0.74 8.5 3.2 1.2 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 VDK85663.1 - 1.2 10.1 8.6 0.17 12.9 4.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DivIC PF04977.15 VDK85663.1 - 1.4 8.7 9.7 0.2 11.4 4.8 2.0 2 0 0 2 2 2 0 Septum formation initiator ALMT PF11744.8 VDK85663.1 - 1.6 7.4 8.7 2 7.2 8.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter YfhO PF09586.10 VDK85663.1 - 2.6 6.2 12.1 2.9 6.0 12.1 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO WD40 PF00400.32 VDK85664.1 - 2.7e-27 94.5 30.5 0.00038 21.2 0.2 10.7 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK85664.1 - 8.8e-05 22.7 4.1 8.3 6.8 0.0 6.4 4 2 4 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_S28e PF01200.18 VDK85665.1 - 6.4e-32 109.3 0.2 7e-32 109.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e SSrecog PF03531.14 VDK85666.1 - 3e-27 94.3 0.6 2.7e-25 88.0 0.0 4.1 5 0 0 5 5 5 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 VDK85666.1 - 2.3e-24 85.6 0.7 3.6e-23 81.8 0.0 3.0 4 1 0 4 4 4 1 Histone chaperone Rttp106-like POB3_N PF17292.2 VDK85666.1 - 8e-23 80.7 1.4 7.3e-21 74.4 0.5 2.6 2 0 0 2 2 2 1 POB3-like N-terminal PH domain HMG_box PF00505.19 VDK85666.1 - 1.4e-15 57.5 9.1 4.3e-15 55.9 9.1 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK85666.1 - 2.4e-11 44.0 9.4 1e-10 42.1 9.4 2.1 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 VDK85666.1 - 0.1 12.6 6.3 0.31 11.1 6.3 1.8 1 0 0 1 1 1 0 HMG (high mobility group) box 5 PID PF00640.23 VDK85667.1 - 2.6e-29 102.1 0.1 3.9e-29 101.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 VDK85667.1 - 5.7e-08 33.0 0.1 9.6e-08 32.3 0.1 1.3 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 VDK85667.1 - 3.8e-06 26.9 0.0 5.9e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) MIS13 PF08202.11 VDK85667.1 - 0.012 14.9 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Mis12-Mtw1 protein family PEX-2N PF09263.10 VDK85667.1 - 0.089 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal Ecm29 PF13001.7 VDK85675.1 - 6.5e-76 256.0 5.5 6.5e-76 256.0 5.5 3.2 3 0 0 3 3 3 1 Proteasome stabiliser Vac14_Fab1_bd PF12755.7 VDK85675.1 - 3.9e-08 33.8 4.9 0.00021 21.8 0.1 6.5 6 1 1 7 7 7 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 VDK85675.1 - 7.7e-05 23.1 0.3 18 6.0 0.0 6.0 6 0 0 6 6 6 1 HEAT-like repeat DRMBL PF07522.14 VDK85675.1 - 0.0016 18.6 0.1 0.0067 16.6 0.1 2.1 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase HEAT PF02985.22 VDK85675.1 - 0.0044 17.1 7.3 6.4 7.3 0.1 7.4 7 0 0 7 7 7 1 HEAT repeat Lactamase_B_2 PF12706.7 VDK85675.1 - 0.025 14.1 0.1 0.049 13.1 0.1 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B PF00753.27 VDK85675.1 - 0.025 14.6 0.1 0.14 12.2 0.1 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily EAP30 PF04157.16 VDK85675.1 - 0.15 11.3 0.8 0.47 9.7 0.0 2.2 2 0 0 2 2 2 0 EAP30/Vps36 family Glyco_hydro_31 PF01055.26 VDK85676.1 - 1.5e-139 466.0 2.4 1.5e-139 466.0 2.4 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 VDK85676.1 - 1.4e-21 76.6 0.1 5.6e-20 71.4 0.1 2.7 2 0 0 2 2 2 1 Galactose mutarotase-like HAD_2 PF13419.6 VDK85682.1 - 4.9e-26 91.9 0.0 6.2e-26 91.6 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 VDK85682.1 - 1.9e-11 44.6 0.0 2.2e-09 37.9 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDK85682.1 - 0.0034 17.8 0.0 0.0053 17.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 VDK85682.1 - 0.014 15.5 0.0 5.4 7.2 0.0 2.4 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 VDK85682.1 - 0.061 13.4 0.0 0.095 12.8 0.0 1.3 1 0 0 1 1 1 0 HAD-hyrolase-like TDP43_N PF18694.1 VDK85683.1 - 2e-17 62.8 0.0 4.1e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain MscS_porin PF12795.7 VDK85683.1 - 1.4e-05 24.8 17.2 1.4e-05 24.8 17.2 9.0 5 3 3 9 9 9 4 Mechanosensitive ion channel porin domain APG6_N PF17675.1 VDK85683.1 - 0.00022 21.8 8.4 0.00022 21.8 8.4 12.8 5 2 8 13 13 13 2 Apg6 coiled-coil region DUF641 PF04859.12 VDK85683.1 - 0.0022 18.3 3.1 0.0022 18.3 3.1 14.6 8 5 5 15 15 15 3 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 VDK85683.1 - 0.0027 17.9 5.9 0.0027 17.9 5.9 11.5 2 2 9 11 11 11 4 Uncharacterised protein family (UPF0242) N-terminus Pam17 PF08566.10 VDK85683.1 - 3.3 7.5 6.7 0.77 9.6 0.3 3.1 4 0 0 4 4 4 0 Mitochondrial import protein Pam17 Sugarporin_N PF11471.8 VDK85683.1 - 5.3 7.1 14.2 23 5.0 0.1 6.0 5 0 0 5 5 5 0 Maltoporin periplasmic N-terminal extension Integrin_alpha2 PF08441.12 VDK85685.1 - 7.4e-81 272.4 0.2 1e-80 271.9 0.2 1.1 1 0 0 1 1 1 1 Integrin alpha FG-GAP PF01839.23 VDK85685.1 - 1.1e-16 60.6 26.8 3e-10 40.0 2.3 4.6 4 0 0 4 4 4 3 FG-GAP repeat Integrin_alpha PF00357.20 VDK85685.1 - 9.2e-05 22.1 0.4 0.00025 20.8 0.4 1.8 1 0 0 1 1 1 1 Integrin alpha cytoplasmic region VCBS PF13517.6 VDK85685.1 - 0.00027 21.5 8.2 0.14 12.8 1.2 3.5 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Na_sulph_symp PF00939.19 VDK85690.1 - 1.5e-66 225.4 24.5 3.4e-35 122.0 4.2 2.0 1 1 1 2 2 2 2 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 VDK85690.1 - 6.1e-30 104.4 44.5 9.6e-15 54.5 9.3 3.2 2 1 1 3 3 3 3 Citrate transporter Glyco_hydro_20 PF00728.22 VDK85691.1 - 1.2e-09 38.0 0.1 2.7e-09 36.9 0.1 1.7 1 1 1 2 2 2 1 Glycosyl hydrolase family 20, catalytic domain Glutaredoxin PF00462.24 VDK85693.1 - 3.1e-12 46.5 0.0 4.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 VDK85693.1 - 0.032 14.3 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_2 PF13098.6 VDK85693.1 - 0.14 12.7 0.0 0.23 11.9 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin-like domain Pkinase PF00069.25 VDK85701.1 - 4.6e-74 249.1 0.0 7.1e-74 248.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK85701.1 - 1.2e-46 159.1 0.0 1.9e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 VDK85701.1 - 2.1e-18 65.8 0.0 3.7e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 VDK85701.1 - 1.1e-07 31.5 0.0 1.9e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK85701.1 - 8.4e-05 22.0 0.2 0.00016 21.1 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 VDK85701.1 - 0.00098 18.8 0.3 0.002 17.8 0.3 1.4 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 VDK85701.1 - 0.0042 16.1 0.0 0.0084 15.1 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain UBA PF00627.31 VDK85701.1 - 0.071 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain 53-BP1_Tudor PF09038.10 VDK85701.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 Tumour suppressor p53-binding protein-1 Tudor Zona_pellucida PF00100.23 VDK85709.1 - 0.00025 20.9 0.6 0.0003 20.7 0.6 1.0 1 0 0 1 1 1 1 Zona pellucida-like domain Pex24p PF06398.11 VDK85709.1 - 0.13 11.2 0.1 0.13 11.2 0.1 1.4 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Bestrophin PF01062.21 VDK85716.1 - 1.7e-78 264.0 7.2 2.9e-78 263.2 7.2 1.4 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel cwf21 PF08312.12 VDK85718.1 - 7.8e-11 42.0 1.2 7.8e-11 42.0 1.2 1.9 2 0 0 2 2 2 1 cwf21 domain Transposase_22 PF02994.14 VDK85718.1 - 0.036 14.2 0.2 2.5 8.3 0.0 2.4 2 0 0 2 2 2 0 L1 transposable element RBD-like domain Bromodomain PF00439.25 VDK85720.1 - 2.6e-23 81.9 0.6 5.1e-23 80.9 0.6 1.5 1 0 0 1 1 1 1 Bromodomain PHD PF00628.29 VDK85720.1 - 9.5e-20 70.2 25.1 4.3e-11 42.5 6.7 2.5 2 0 0 2 2 2 2 PHD-finger PHD_2 PF13831.6 VDK85720.1 - 0.00013 21.4 13.8 0.042 13.4 4.0 2.7 2 0 0 2 2 2 2 PHD-finger PHD_4 PF16866.5 VDK85720.1 - 3.3 7.9 19.9 5 7.3 3.8 3.2 2 1 1 3 3 3 0 PHD-finger PBP1_TM PF14812.6 VDK85722.1 - 0.0093 16.3 2.1 0.0093 16.3 2.1 2.8 3 0 0 3 3 3 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Myc_N PF01056.18 VDK85722.1 - 0.017 15.0 0.4 0.035 14.0 0.4 1.5 1 0 0 1 1 1 0 Myc amino-terminal region CDC27 PF09507.10 VDK85722.1 - 9.1 5.6 9.2 14 4.9 2.2 2.5 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 CBFD_NFYB_HMF PF00808.23 VDK85724.1 - 2.4e-24 85.4 0.1 3.9e-24 84.7 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK85724.1 - 3.9e-06 27.3 0.8 1.2e-05 25.7 0.0 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 NAPRTase PF04095.16 VDK85725.1 - 8.6e-64 215.4 0.0 1.3e-63 214.9 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family DUF5598 PF18127.1 VDK85725.1 - 9.7e-40 135.0 0.9 4.4e-39 132.9 0.4 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF5598) Flavokinase PF01687.17 VDK85725.1 - 1e-30 106.3 0.0 2.3e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 Riboflavin kinase RF-1 PF00472.20 VDK85725.1 - 4.3e-14 52.4 0.5 8.5e-14 51.5 0.5 1.4 1 0 0 1 1 1 1 RF-1 domain Fibin PF15819.5 VDK85725.1 - 0.12 12.1 0.2 0.22 11.3 0.2 1.3 1 0 0 1 1 1 0 Fin bud initiation factor homologue BP28CT PF08146.12 VDK85730.1 - 2.4e-12 47.0 0.5 2.3e-11 43.8 0.2 2.7 2 0 0 2 2 2 1 BP28CT (NUC211) domain MMS19_N PF14500.6 VDK85730.1 - 0.00034 20.3 0.1 0.0097 15.5 0.0 3.1 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II RNB PF00773.19 VDK85731.1 - 2.5e-87 293.3 0.5 5.4e-87 292.2 0.5 1.5 1 1 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 VDK85731.1 - 7.4e-17 61.2 0.0 1.8e-16 59.9 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 VDK85731.1 - 1.1e-15 57.7 0.0 2.2e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 VDK85731.1 - 6.8e-07 29.4 0.0 3.8e-05 23.8 0.0 2.6 2 0 0 2 2 2 1 Cold shock domain Rrp44_S1 PF17215.3 VDK85731.1 - 2.6e-05 24.1 1.8 2.6e-05 24.1 1.8 2.5 2 1 0 2 2 2 1 S1 domain OB_RNB PF08206.11 VDK85731.1 - 0.0027 17.4 0.0 0.0059 16.3 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease B OB domain Luciferase_N PF05295.11 VDK85731.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain DUF667 PF05018.13 VDK85732.1 - 8.9e-92 305.9 0.6 1e-91 305.7 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Ashwin PF15323.6 VDK85733.1 - 1.7e-05 24.9 0.7 6e-05 23.2 0.1 1.8 1 1 1 2 2 2 1 Developmental protein Myb_Cef PF11831.8 VDK85738.1 - 6.4e-35 120.8 5.6 6.4e-35 120.8 5.6 4.2 4 0 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 VDK85738.1 - 4.3e-19 68.4 6.1 4.2e-11 42.8 1.8 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 VDK85738.1 - 1.7e-17 63.4 6.6 2.7e-12 46.8 2.9 3.1 2 1 1 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.8 VDK85738.1 - 0.48 10.6 5.9 0.23 11.6 0.2 3.4 4 0 0 4 4 4 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain TPR_2 PF07719.17 VDK85740.1 - 8.1e-08 31.8 7.0 0.011 15.8 0.8 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 VDK85740.1 - 1.2e-07 31.2 7.4 0.00035 20.3 0.6 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK85740.1 - 5.7e-07 29.7 8.0 8.1e-05 22.8 5.7 2.5 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK85740.1 - 0.00011 22.1 6.2 0.2 12.0 0.3 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK85740.1 - 0.00054 20.4 3.7 0.00054 20.4 3.7 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDK85740.1 - 0.00094 18.8 0.9 0.00094 18.8 0.9 3.1 2 1 1 3 3 3 1 TPR repeat TPR_14 PF13428.6 VDK85740.1 - 0.0092 16.7 4.1 1.6 9.8 0.6 3.7 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK85740.1 - 0.015 15.4 0.1 0.034 14.3 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK85740.1 - 0.036 14.4 4.2 0.32 11.5 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 VDK85740.1 - 0.31 11.0 10.2 0.87 9.6 1.1 4.4 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK85740.1 - 1 9.5 3.2 1.2e+02 3.1 0.1 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 VDK85740.1 - 1.4 9.6 6.0 4.3 8.1 4.0 2.6 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK85740.1 - 4.8 8.0 6.7 1.5e+02 3.4 0.3 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Ank_4 PF13637.6 VDK85741.1 - 2.9e-08 34.1 1.1 0.00041 20.9 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDK85741.1 - 2.2e-06 28.2 0.1 4.4e-06 27.2 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK85741.1 - 1.1e-05 25.6 0.1 3.2e-05 24.1 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) LEM PF03020.15 VDK85741.1 - 6.3e-05 22.4 1.7 0.007 15.9 1.7 2.5 1 1 0 1 1 1 1 LEM domain Ank_3 PF13606.6 VDK85741.1 - 0.00017 21.8 0.2 0.029 14.9 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 VDK85741.1 - 0.00022 21.5 0.2 0.0013 19.1 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat TetR_C_28 PF17937.1 VDK85741.1 - 0.034 14.6 0.4 0.081 13.4 0.4 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TetR_C_33 PF13305.6 VDK85741.1 - 0.15 12.8 0.0 0.45 11.3 0.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain CEBP1_N PF16368.5 VDK85742.1 - 0.0022 17.6 2.8 0.0032 17.0 2.8 1.2 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein 1 N-terminus CENP-O PF09496.10 VDK85742.1 - 0.058 13.4 0.9 7.8 6.4 0.1 2.3 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component Poxvirus_B22R_C PF13168.6 VDK85742.1 - 0.068 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Poxvirus B22R protein C-terminal PALP PF00291.25 VDK85753.1 - 2.3e-26 92.9 0.7 6.9e-26 91.3 0.7 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DnaJ PF00226.31 VDK85755.1 - 5.4e-13 48.9 0.5 5.4e-13 48.9 0.5 2.3 2 1 0 2 2 2 1 DnaJ domain DUF3391 PF11871.8 VDK85755.1 - 0.14 12.7 12.1 0.046 14.3 1.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) dCMP_cyt_deam_1 PF00383.23 VDK85756.1 - 9.8e-24 83.2 0.1 1.2e-23 82.9 0.1 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 VDK85756.1 - 9.3e-13 48.1 0.0 1.1e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 VDK85756.1 - 0.12 12.5 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 Homeodomain PF00046.29 VDK85757.1 - 3.3e-20 71.7 1.4 5.2e-20 71.1 1.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK85757.1 - 1.7e-05 24.6 0.1 4.2e-05 23.4 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain Neur_chan_LBD PF02931.23 VDK85766.1 - 8.7e-29 100.5 0.0 1e-28 100.3 0.0 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Diphthami_syn_2 PF01902.17 VDK85766.1 - 0.097 12.2 0.0 0.2 11.1 0.0 1.4 1 1 0 1 1 1 0 Diphthamide synthase Sugar_tr PF00083.24 VDK85767.1 - 7e-31 107.6 18.6 9.5e-31 107.1 18.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK85767.1 - 5.1e-20 71.7 32.8 1.5e-18 66.8 21.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TB2_DP1_HVA22 PF03134.19 VDK85769.1 - 9e-22 76.8 4.1 9.7e-22 76.7 2.2 2.0 2 0 0 2 2 2 1 TB2/DP1, HVA22 family SSB PF00436.25 VDK85775.1 - 0.00015 21.8 0.0 0.00067 19.7 0.0 1.9 1 1 0 1 1 1 1 Single-strand binding protein family tRNA_anti-codon PF01336.25 VDK85775.1 - 0.07 13.1 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain SSB PF00436.25 VDK85777.1 - 5.9e-09 35.9 0.1 9.7e-09 35.2 0.1 1.3 1 0 0 1 1 1 1 Single-strand binding protein family NCBP3 PF10309.9 VDK85777.1 - 0.026 14.4 0.0 4.6 7.2 0.0 2.4 2 0 0 2 2 2 0 Nuclear cap-binding protein subunit 3 DUF4131 PF13567.6 VDK85777.1 - 0.15 11.7 0.3 7.6 6.2 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Epimerase PF01370.21 VDK85779.1 - 6.1e-43 147.0 0.0 2e-40 138.8 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 VDK85779.1 - 5.9e-13 48.9 1.5 6.5e-07 29.1 0.0 2.9 2 1 1 3 3 3 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 VDK85779.1 - 5.9e-08 32.2 0.0 1.1e-07 31.2 0.0 1.4 2 0 0 2 2 2 1 RmlD substrate binding domain KR PF08659.10 VDK85779.1 - 0.015 15.2 1.4 2 8.3 0.2 2.3 1 1 1 2 2 2 0 KR domain Polysacc_synt_2 PF02719.15 VDK85779.1 - 0.027 13.6 3.1 1 8.4 0.1 3.0 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein UQ_con PF00179.26 VDK85780.1 - 7e-42 142.4 0.1 8.8e-42 142.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 VDK85780.1 - 0.0019 18.5 0.0 0.0025 18.1 0.0 1.4 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 VDK85780.1 - 0.0027 17.6 0.0 0.012 15.4 0.0 2.0 2 0 0 2 2 2 1 UEV domain Prok-E2_B PF14461.6 VDK85780.1 - 0.046 13.4 0.0 0.068 12.9 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B MCM PF00493.23 VDK85781.1 - 4.1e-99 330.2 0.1 6.4e-99 329.6 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 VDK85781.1 - 1.8e-35 121.5 0.4 4.5e-35 120.3 0.4 1.6 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 VDK85781.1 - 1.4e-26 92.8 3.9 1.4e-26 92.8 3.9 2.3 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 VDK85781.1 - 5.6e-25 87.6 1.9 1.1e-24 86.7 0.5 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 VDK85781.1 - 1.2e-13 51.6 0.9 1.2e-13 51.6 0.9 2.4 3 0 0 3 3 3 1 MCM N-terminal domain Mg_chelatase PF01078.21 VDK85781.1 - 3.8e-07 29.7 0.0 1.3e-06 28.0 0.0 1.9 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 VDK85781.1 - 7.5e-05 22.6 0.0 0.00021 21.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 VDK85781.1 - 0.00026 21.0 0.0 0.00068 19.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 VDK85781.1 - 0.006 16.3 0.0 0.022 14.5 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 VDK85781.1 - 0.17 12.5 2.0 0.64 10.7 0.2 2.9 3 1 1 4 4 4 0 Magnesium chelatase, subunit ChlI C-terminal TPR_12 PF13424.6 VDK85782.1 - 2.9e-17 62.7 20.5 1.9e-05 24.8 0.6 6.4 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 VDK85782.1 - 1.1e-08 34.6 11.0 0.0086 15.9 0.1 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 VDK85782.1 - 4.7e-07 29.5 22.9 0.054 13.7 0.1 8.5 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK85782.1 - 1.8e-05 24.3 8.3 0.00091 18.7 0.6 3.7 1 1 1 3 3 3 2 MalT-like TPR region TPR_2 PF07719.17 VDK85782.1 - 0.00015 21.6 39.0 0.093 12.9 0.0 10.0 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_7 PF13176.6 VDK85782.1 - 0.00028 20.7 13.1 7.4 6.9 0.1 6.8 5 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDK85782.1 - 0.052 14.1 11.5 17 6.0 0.4 5.9 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK85782.1 - 0.14 12.1 37.3 2.5 8.0 0.1 8.4 10 0 0 10 10 10 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK85782.1 - 0.79 10.0 21.8 4.1 7.7 0.1 6.6 6 1 1 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 VDK85782.1 - 1.9 9.3 6.4 3.5e+02 2.2 0.0 5.6 6 0 0 6 6 4 0 Tetratricopeptide repeat YfiO PF13525.6 VDK85782.1 - 2.7 7.7 6.4 1.3 8.7 0.1 3.0 4 0 0 4 4 4 0 Outer membrane lipoprotein Lipid_DES PF08557.10 VDK85785.1 - 7.5e-19 66.9 0.2 1.2e-18 66.3 0.2 1.3 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) FA_desaturase PF00487.24 VDK85785.1 - 4.8e-10 39.7 2.4 5.4e-10 39.5 1.4 1.5 2 0 0 2 2 2 1 Fatty acid desaturase ILEI PF15711.5 VDK85786.1 - 1.4e-36 124.8 1.6 2.2e-25 89.0 0.0 2.8 3 0 0 3 3 3 2 Interleukin-like EMT inducer Methyltransf_11 PF08241.12 VDK85787.1 - 2.8e-13 50.3 0.0 8.1e-11 42.4 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK85787.1 - 6.8e-13 49.1 0.0 5.7e-09 36.6 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 VDK85787.1 - 2.8e-10 40.2 0.5 9.2e-09 35.3 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK85787.1 - 3.7e-07 30.1 0.0 0.016 15.0 0.0 2.6 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 VDK85787.1 - 2.2e-06 28.3 0.0 0.00017 22.3 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Spermine_synth PF01564.17 VDK85787.1 - 9.4e-06 25.2 0.2 0.00015 21.2 0.0 2.7 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Ubie_methyltran PF01209.18 VDK85787.1 - 3.8e-05 23.1 0.3 0.00014 21.3 0.1 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 VDK85787.1 - 0.00041 19.9 0.0 0.22 11.1 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase small domain PrmA PF06325.13 VDK85787.1 - 0.023 14.1 0.0 0.19 11.1 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_3 PF01596.17 VDK85787.1 - 0.029 13.5 0.0 0.067 12.3 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_2 PF00891.18 VDK85787.1 - 0.084 12.2 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain Snf7 PF03357.21 VDK85791.1 - 4.9e-51 172.8 20.0 5.8e-51 172.5 20.0 1.1 1 0 0 1 1 1 1 Snf7 Spc7 PF08317.11 VDK85791.1 - 0.013 14.4 12.7 0.011 14.6 11.5 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Prefoldin_2 PF01920.20 VDK85791.1 - 0.02 14.8 0.1 0.02 14.8 0.1 3.8 2 1 0 3 3 3 0 Prefoldin subunit FUSC PF04632.12 VDK85791.1 - 0.036 12.6 1.5 0.045 12.3 1.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3549 PF12069.8 VDK85791.1 - 0.044 12.8 2.7 0.061 12.4 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3549) BORCS8 PF10167.9 VDK85791.1 - 0.17 11.9 4.4 0.14 12.1 2.3 1.9 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 8 Flagellin_N PF00669.20 VDK85791.1 - 0.22 11.6 7.1 2.2 8.4 0.4 2.5 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region Leu_zip PF15294.6 VDK85791.1 - 0.32 10.5 14.9 0.63 9.5 14.8 1.3 1 1 0 1 1 1 0 Leucine zipper DUF948 PF06103.11 VDK85791.1 - 0.46 10.8 2.3 2.7 8.3 0.7 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin PF02996.17 VDK85791.1 - 0.55 10.1 0.1 0.55 10.1 0.1 3.5 2 1 2 4 4 4 0 Prefoldin subunit NPV_P10 PF05531.12 VDK85791.1 - 0.64 10.5 9.7 1.4 9.4 1.8 3.4 2 1 2 4 4 4 0 Nucleopolyhedrovirus P10 protein RPW8 PF05659.11 VDK85791.1 - 0.71 9.6 10.8 0.39 10.4 4.2 2.7 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 NuA4 PF09340.10 VDK85791.1 - 0.82 9.6 3.8 1.1 9.2 0.6 2.6 3 1 0 3 3 3 0 Histone acetyltransferase subunit NuA4 GTP-bdg_M PF16360.5 VDK85791.1 - 1.3 9.7 8.8 4.3 8.0 2.1 3.1 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region Uso1_p115_C PF04871.13 VDK85791.1 - 1.8 9.0 19.4 4.4 7.7 14.6 2.8 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Prominin PF05478.11 VDK85791.1 - 1.9 6.3 6.6 2.7 5.8 6.6 1.2 1 0 0 1 1 1 0 Prominin MerR-DNA-bind PF09278.11 VDK85791.1 - 2 9.0 0.0 2 9.0 0.0 3.1 4 0 0 4 4 4 0 MerR, DNA binding DUF1664 PF07889.12 VDK85791.1 - 2.4 8.2 15.1 13 5.8 3.5 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) SOGA PF11365.8 VDK85791.1 - 3 9.1 10.1 6.2 8.0 5.3 2.4 1 1 1 2 2 2 0 Protein SOGA FlaC_arch PF05377.11 VDK85791.1 - 3.4 8.1 12.2 3.2 8.2 0.3 3.1 2 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Atg14 PF10186.9 VDK85791.1 - 3.6 6.6 11.2 5.6 6.0 10.9 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 VDK85791.1 - 6.9 5.1 17.6 0.83 8.2 7.4 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A WXG100 PF06013.12 VDK85791.1 - 7.7 6.8 14.7 28 5.1 7.2 3.8 3 1 1 4 4 4 0 Proteins of 100 residues with WXG ABC_tran_CTD PF16326.5 VDK85791.1 - 8.9 6.7 17.6 3.3 8.0 2.3 3.3 1 1 3 4 4 4 0 ABC transporter C-terminal domain tRNA-synt_1 PF00133.22 VDK85793.1 - 0.073 11.3 0.0 0.077 11.2 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) SMK-1 PF04802.15 VDK85795.1 - 3e-70 236.0 2.7 7e-70 234.7 2.7 1.7 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 Ground-like PF04155.18 VDK85796.1 - 2.7e-10 40.7 0.2 3.1e-10 40.6 0.2 1.1 1 0 0 1 1 1 1 Ground-like domain ARL2_Bind_BART PF11527.8 VDK85796.1 - 0.0096 16.0 0.1 0.013 15.6 0.1 1.1 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART MADF_DNA_bdg PF10545.9 VDK85797.1 - 4.8e-11 42.8 0.1 1.4e-10 41.3 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK85797.1 - 0.00092 19.5 0.0 0.0027 18.1 0.0 1.8 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain zf-CCCH_2 PF14608.6 VDK85802.1 - 0.002 18.5 3.5 0.002 18.5 3.5 3.1 3 0 0 3 3 3 1 RNA-binding, Nab2-type zinc finger NYN PF01936.18 VDK85803.1 - 0.049 14.1 0.0 0.1 13.0 0.0 1.6 2 0 0 2 2 2 0 NYN domain zf-HC5HC2H PF13771.6 VDK85804.1 - 0.00011 22.3 2.3 0.00079 19.6 0.2 2.8 2 1 0 2 2 2 1 PHD-like zinc-binding domain DUF4706 PF15797.5 VDK85804.1 - 0.23 12.0 3.0 0.34 11.5 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) Mpp10 PF04006.12 VDK85804.1 - 0.46 8.9 11.0 0.54 8.6 11.0 1.0 1 0 0 1 1 1 0 Mpp10 protein Eapp_C PF10238.9 VDK85804.1 - 5.1 7.2 8.4 64 3.6 8.4 2.2 1 1 0 1 1 1 0 E2F-associated phosphoprotein F-box PF00646.33 VDK85805.1 - 0.00019 21.2 0.2 0.0003 20.6 0.2 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 VDK85805.1 - 0.0034 17.2 0.1 0.005 16.7 0.1 1.2 1 0 0 1 1 1 1 F-box-like DUF2153 PF09921.9 VDK85805.1 - 0.024 14.5 0.1 0.027 14.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) F-box_4 PF15966.5 VDK85805.1 - 0.062 13.2 0.1 0.078 12.9 0.1 1.1 1 0 0 1 1 1 0 F-box zf-H2C2_5 PF13909.6 VDK85807.1 - 8.2e-11 41.5 3.4 1.2e-06 28.1 0.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 VDK85807.1 - 0.042 14.7 8.8 0.41 11.6 1.7 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger GAGA PF09237.11 VDK85807.1 - 0.043 13.6 0.4 2.4 8.0 0.0 2.6 2 0 0 2 2 2 0 GAGA factor zf-Di19 PF05605.12 VDK85807.1 - 0.083 13.2 2.4 3.4 8.0 0.1 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding AKAP95 PF04988.12 VDK85807.1 - 0.16 12.2 0.7 1.2 9.4 0.1 2.2 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2 PF00096.26 VDK85807.1 - 0.17 12.4 10.6 0.061 13.8 2.5 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type Zn_Tnp_IS1595 PF12760.7 VDK85807.1 - 1.3 9.0 3.1 16 5.6 0.3 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain DUF3290 PF11694.8 VDK85814.1 - 0.033 14.2 0.1 0.1 12.6 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3290) Phage_CII PF05269.11 VDK85814.1 - 0.085 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage CII protein KHA PF11834.8 VDK85814.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.6 1 1 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel NDK PF00334.19 VDK85816.1 - 1e-09 38.5 0.0 1.3e-09 38.2 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Tim44 PF04280.15 VDK85819.1 - 1.1e-39 135.8 0.0 3.4e-39 134.3 0.0 1.8 1 0 0 1 1 1 1 Tim44-like domain MIF4G PF02854.19 VDK85819.1 - 0.0025 17.5 1.4 0.0049 16.5 1.4 1.5 1 0 0 1 1 1 1 MIF4G domain HMGL-like PF00682.19 VDK85819.1 - 0.062 12.8 1.2 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 HMGL-like Complex1_LYR PF05347.15 VDK85819.1 - 0.17 11.9 3.8 0.44 10.6 3.4 2.0 1 1 0 1 1 1 0 Complex 1 protein (LYR family) GlnE PF03710.15 VDK85819.1 - 1.9 7.8 6.6 6.1 6.2 6.6 1.8 1 1 0 1 1 1 0 Glutamate-ammonia ligase adenylyltransferase DivIC PF04977.15 VDK85819.1 - 2.3 8.1 12.6 0.1 12.4 4.7 2.4 2 0 0 2 2 2 0 Septum formation initiator HeLo PF14479.6 VDK85819.1 - 6.9 6.4 13.1 12 5.7 10.4 2.3 1 1 1 2 2 2 0 Prion-inhibition and propagation Cas_DxTHG PF09455.10 VDK85819.1 - 7 6.1 14.9 4.8 6.7 13.4 1.5 1 1 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family DUF3347 PF11827.8 VDK85819.1 - 7.7 6.7 11.2 2.9 8.0 4.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3347) DivIVA PF05103.13 VDK85819.1 - 7.8 6.6 20.9 8.5 6.5 1.9 3.3 1 1 1 2 2 2 0 DivIVA protein DUF3509 PF12021.8 VDK85821.1 - 0.094 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3509) 6PF2K PF01591.18 VDK85823.1 - 6.5e-89 297.0 0.0 9.9e-89 296.4 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 VDK85823.1 - 2e-41 141.8 0.0 3e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 VDK85823.1 - 1.2e-05 25.5 0.0 2.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 VDK85823.1 - 0.049 14.2 0.0 0.16 12.5 0.0 1.9 2 1 1 3 3 3 0 AAA domain AAA_17 PF13207.6 VDK85823.1 - 0.17 12.3 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 VDK85823.1 - 0.18 11.0 0.1 0.75 9.0 0.0 2.0 3 0 0 3 3 3 0 Zeta toxin RhoGEF PF00621.20 VDK85827.1 - 4.2e-26 92.3 2.4 4.2e-26 92.3 2.4 2.4 2 1 0 2 2 2 1 RhoGEF domain PH_13 PF16652.5 VDK85827.1 - 3.1e-11 43.3 1.2 5.7e-11 42.5 0.2 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 VDK85827.1 - 0.00026 21.4 0.4 0.00094 19.7 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_16 PF17838.1 VDK85827.1 - 0.0012 18.7 0.3 0.011 15.6 0.3 2.4 1 1 0 1 1 1 1 PH domain PH_5 PF15405.6 VDK85827.1 - 0.0013 18.9 0.0 0.0045 17.1 0.0 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_10 PF15411.6 VDK85827.1 - 0.032 14.5 0.2 0.081 13.2 0.2 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 VDK85827.1 - 0.3 11.1 3.7 0.35 10.8 1.4 2.2 2 1 0 2 2 2 0 PH domain TRAPPC10 PF12584.8 VDK85828.1 - 0.057 13.1 0.0 0.27 10.9 0.0 2.1 1 1 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 FOG_N PF15888.5 VDK85832.1 - 0.0013 19.1 0.0 0.0017 18.7 0.0 1.2 1 0 0 1 1 1 1 Folded gastrulation N-terminus CoA_binding_3 PF13727.6 VDK85832.1 - 0.02 14.9 0.3 0.031 14.3 0.3 1.3 1 0 0 1 1 1 0 CoA-binding domain WASH-7_C PF14746.6 VDK85833.1 - 0.08 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal zf-C2H2_2 PF12756.7 VDK85833.1 - 1.5 9.2 16.2 1.4 9.3 0.5 3.9 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 VDK85833.1 - 6.6 7.9 15.3 25 6.0 0.3 4.1 3 0 0 3 3 3 0 C2H2-type zinc finger Dzip-like_N PF13815.6 VDK85834.1 - 4.4e-10 39.5 1.0 6.8e-10 38.9 1.0 1.2 1 0 0 1 1 1 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal bZIP_1 PF00170.21 VDK85834.1 - 0.0043 17.1 0.1 0.0082 16.2 0.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor Ribonuc_red_lgN PF00317.21 VDK85834.1 - 0.025 14.6 0.1 0.045 13.8 0.1 1.4 1 0 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain GIT_CC PF16559.5 VDK85834.1 - 0.031 14.1 0.5 0.056 13.3 0.5 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor APC_N_CC PF16689.5 VDK85834.1 - 0.13 12.3 2.0 0.41 10.7 2.0 1.9 1 1 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain YabA PF06156.13 VDK85834.1 - 0.15 12.7 1.6 0.22 12.2 1.6 1.2 1 0 0 1 1 1 0 Initiation control protein YabA Tmemb_14 PF03647.13 VDK85837.1 - 2.4e-20 73.0 14.2 3.4e-20 72.6 14.2 1.2 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF608 PF04685.13 VDK85838.1 - 2.8e-15 56.3 0.3 3.1e-15 56.2 0.3 1.0 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region TSC22 PF01166.18 VDK85844.1 - 0.12 12.7 0.2 0.25 11.7 0.2 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family XRN_M PF17846.1 VDK85845.1 - 7.1e-92 308.7 3.1 7.1e-92 308.7 3.1 2.2 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 VDK85845.1 - 8.4e-90 300.4 0.0 2e-89 299.2 0.0 1.7 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 VDK85845.1 - 1.4e-26 93.4 1.0 1.8e-26 93.1 0.0 1.7 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 VDK85845.1 - 1.7e-13 50.4 0.0 5.1e-13 48.9 0.0 1.9 1 0 0 1 1 1 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 VDK85845.1 - 0.0026 17.9 0.0 0.008 16.4 0.0 1.9 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain Meiosis_expr PF15163.6 VDK85845.1 - 1.7 9.4 5.0 0.6 10.8 1.4 2.1 2 0 0 2 2 2 0 Meiosis-expressed Vitellogenin_N PF01347.22 VDK85846.1 - 3.4e-57 194.2 0.3 3.4e-57 194.2 0.3 1.5 2 0 0 2 2 2 1 Lipoprotein amino terminal region DUF1943 PF09172.11 VDK85846.1 - 2.3e-47 161.8 0.4 4.4e-47 160.8 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) ACT_4 PF13291.6 VDK85846.1 - 0.068 13.8 0.2 0.34 11.5 0.2 2.2 1 0 0 1 1 1 0 ACT domain zf-C2H2_3rep PF18868.1 VDK85849.1 - 6.5e-05 23.6 3.3 1.3 9.7 0.0 3.7 3 0 0 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 VDK85849.1 - 0.0033 17.7 7.7 0.061 13.6 0.1 3.1 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 VDK85849.1 - 0.0039 17.9 14.2 0.28 12.1 2.2 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK85849.1 - 0.006 17.0 2.6 0.006 17.0 2.6 3.8 3 0 0 3 3 3 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 VDK85849.1 - 0.019 15.6 0.1 12 6.7 0.1 2.9 2 0 0 2 2 2 0 FOXP coiled-coil domain zf_Hakai PF18408.1 VDK85849.1 - 0.025 14.3 0.1 0.055 13.2 0.1 1.6 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain zf-C2H2_11 PF16622.5 VDK85849.1 - 0.043 13.6 2.2 0.15 11.8 2.2 2.0 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 VDK85849.1 - 0.18 12.3 10.0 6.2 7.4 0.0 4.3 5 0 0 5 5 5 0 Zinc-finger double domain zinc_ribbon_10 PF10058.9 VDK85849.1 - 0.24 11.2 2.4 7.8 6.3 0.3 2.5 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-C2H2_jaz PF12171.8 VDK85849.1 - 0.29 11.5 2.3 0.83 10.0 2.3 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding E3_UbLigase_EDD PF11547.8 VDK85852.1 - 1.3e-28 98.5 4.2 3.3e-28 97.1 4.2 1.8 1 0 0 1 1 1 1 E3 ubiquitin ligase EDD KORA PF16509.5 VDK85852.1 - 0.035 14.4 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 TrfB plasmid transcriptional repressor Ank_2 PF12796.7 VDK85852.1 - 0.067 13.8 0.1 7.5 7.2 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Ras PF00071.22 VDK85857.1 - 4.2e-58 195.5 0.1 5.7e-58 195.1 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK85857.1 - 1.9e-31 108.8 0.0 3.1e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK85857.1 - 9.1e-11 41.5 0.0 1.7e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK85857.1 - 2.6e-06 27.5 0.0 4.4e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDK85857.1 - 0.00037 20.4 0.1 0.0074 16.2 0.1 2.5 3 0 0 3 3 3 1 RsgA GTPase Gtr1_RagA PF04670.12 VDK85857.1 - 0.00047 19.6 0.0 0.00076 18.9 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 VDK85857.1 - 0.011 15.3 0.0 0.23 11.0 0.0 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 VDK85857.1 - 0.015 15.6 0.0 0.034 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 VDK85857.1 - 0.02 14.3 0.1 0.039 13.4 0.1 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 VDK85857.1 - 0.024 15.0 0.0 0.043 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 VDK85857.1 - 0.028 13.9 0.1 0.049 13.1 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 VDK85857.1 - 0.041 13.1 0.1 0.076 12.3 0.1 1.4 1 0 0 1 1 1 0 Septin AAA_24 PF13479.6 VDK85857.1 - 0.05 13.3 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 VDK85857.1 - 0.077 12.6 0.0 0.24 11.0 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 VDK85857.1 - 0.086 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 VDK85857.1 - 0.097 12.4 0.6 0.28 10.9 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 VDK85857.1 - 0.15 11.3 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain MCM PF00493.23 VDK85857.1 - 0.17 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain DAP3 PF10236.9 VDK85857.1 - 0.17 11.0 0.1 0.26 10.4 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 GILT PF03227.16 VDK85858.1 - 3.2e-29 101.3 0.1 4.3e-29 100.9 0.1 1.2 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) YTH PF04146.15 VDK85859.1 - 1.7e-23 83.4 5.5 7.4e-22 78.1 0.0 3.8 3 1 0 3 3 3 2 YT521-B-like domain Fer2_4 PF13510.6 VDK85859.1 - 0.06 13.4 0.1 0.2 11.7 0.1 1.9 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain U1snRNP70_N PF12220.8 VDK85860.1 - 1.5e-23 83.2 5.3 1.5e-23 83.2 5.3 2.2 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 VDK85860.1 - 2.6e-15 56.0 0.2 1.3e-13 50.5 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 VDK85860.1 - 0.11 12.5 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 RL domain TTR-52 PF01060.23 VDK85861.1 - 9.6e-27 93.5 0.0 1.3e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family Ribosomal_L50 PF10501.9 VDK85861.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal subunit 39S TTR-52 PF01060.23 VDK85862.1 - 9.5e-26 90.3 0.0 1.2e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family CarboxypepD_reg PF13620.6 VDK85862.1 - 0.04 14.2 0.0 0.062 13.6 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Glug PF07581.12 VDK85862.1 - 0.48 10.9 3.6 2.9 8.5 1.1 2.5 2 0 0 2 2 2 0 The GLUG motif TTR-52 PF01060.23 VDK85863.1 - 2e-26 92.5 0.0 2.8e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family bMG3 PF11974.8 VDK85863.1 - 0.053 13.5 0.0 0.074 13.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain UPF0731 PF14982.6 VDK85863.1 - 0.1 12.8 0.2 0.31 11.2 0.0 1.7 2 0 0 2 2 2 0 UPF0731 family CarboxypepD_reg PF13620.6 VDK85863.1 - 0.13 12.5 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain DUF4198 PF10670.9 VDK85863.1 - 0.27 11.6 0.0 0.39 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) MADF_DNA_bdg PF10545.9 VDK85864.1 - 5.4e-10 39.5 1.7 8.4e-10 38.8 0.1 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK85864.1 - 0.01 16.2 0.0 0.028 14.8 0.0 1.8 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Nucleoporin_FG PF13634.6 VDK85868.1 - 0.006 17.4 4.5 0.0091 16.8 4.5 1.3 1 1 0 1 1 1 1 Nucleoporin FG repeat region Endonuc-EcoRV PF09233.11 VDK85868.1 - 0.083 12.2 0.1 0.093 12.1 0.1 1.0 1 0 0 1 1 1 0 Restriction endonuclease EcoRV DUF273 PF03314.14 VDK85870.1 - 2e-56 191.0 2.5 2e-56 191.0 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF273 Glyco_transf_34 PF05637.12 VDK85870.1 - 0.014 15.1 0.4 0.85 9.3 0.0 2.2 1 1 1 2 2 2 0 galactosyl transferase GMA12/MNN10 family Anp1 PF03452.14 VDK85870.1 - 0.05 13.0 0.1 0.084 12.3 0.1 1.3 1 0 0 1 1 1 0 Anp1 OLF PF02191.16 VDK85871.1 - 6.3e-60 202.8 6.2 7.5e-60 202.5 6.2 1.1 1 0 0 1 1 1 1 Olfactomedin-like domain Collagen PF01391.18 VDK85871.1 - 4.7e-08 32.7 24.9 7.4e-08 32.0 24.9 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) APP_E2 PF12925.7 VDK85871.1 - 0.14 11.8 0.2 0.33 10.6 0.0 1.6 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein Hexokinase_2 PF03727.16 VDK85872.1 - 2.8e-67 226.6 0.0 3.9e-67 226.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 VDK85872.1 - 9e-67 224.8 0.1 2e-66 223.7 0.0 1.6 2 0 0 2 2 2 1 Hexokinase Raco_middle PF17651.1 VDK85872.1 - 0.01 15.5 0.8 0.35 10.6 0.0 2.8 3 0 0 3 3 3 0 RACo middle region SH3BP5 PF05276.14 VDK85877.1 - 2.3e-78 263.2 25.0 2.8e-78 262.9 25.0 1.0 1 0 0 1 1 1 1 SH3 domain-binding protein 5 (SH3BP5) DNA_pol_B_2 PF03175.13 VDK85877.1 - 0.026 13.4 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral DegQ PF08181.11 VDK85877.1 - 0.44 10.7 6.3 4.1 7.6 0.4 3.1 3 0 0 3 3 3 0 DegQ (SacQ) family Nrap_D5 PF17406.2 VDK85877.1 - 0.67 9.7 4.1 0.28 10.9 1.6 1.6 2 0 0 2 2 2 0 Nrap protein PAP/OAS1-like domain 5 DUF1664 PF07889.12 VDK85877.1 - 0.77 9.8 11.1 0.14 12.2 1.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Ribosomal_L35p PF01632.19 VDK85879.1 - 0.00026 21.4 0.0 0.00049 20.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L35 Pkinase_Tyr PF07714.17 VDK85881.1 - 8.9e-71 238.2 0.0 1.3e-70 237.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK85881.1 - 4.6e-41 140.9 0.0 1e-40 139.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK85881.1 - 2.1e-08 34.1 0.0 9.1e-08 32.1 0.0 2.1 2 0 0 2 2 2 1 SH2 domain DUF87 PF01935.17 VDK85881.1 - 0.8 9.8 4.4 1.6 8.8 4.4 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain PP2C_C PF07830.13 VDK85881.1 - 7.3 7.1 6.6 9.8 6.7 4.9 2.2 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Coatomer_E PF04733.14 VDK85883.1 - 4.1e-96 321.8 10.1 4.7e-96 321.6 10.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 VDK85883.1 - 5e-06 26.9 11.3 0.0063 17.0 0.4 3.8 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_20 PF14561.6 VDK85883.1 - 8.5e-05 22.8 2.9 0.03 14.6 0.1 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK85883.1 - 0.00027 21.1 5.5 0.032 14.5 0.2 2.7 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 VDK85883.1 - 0.0023 18.6 9.5 0.57 11.1 0.1 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK85883.1 - 0.0067 16.5 3.1 0.26 11.5 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK85883.1 - 0.009 16.3 1.8 1.4 9.3 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 VDK85883.1 - 0.02 14.5 1.0 1.6 8.4 0.1 2.6 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_10 PF13374.6 VDK85883.1 - 0.025 14.5 1.6 0.23 11.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF725 PF05267.12 VDK85883.1 - 0.073 13.1 0.1 1.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF725) Bin3 PF06859.12 VDK85883.1 - 0.079 13.6 0.2 5.2 7.8 0.1 2.5 2 0 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) TPR_8 PF13181.6 VDK85883.1 - 0.079 13.2 2.8 15 6.1 0.1 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK85883.1 - 0.52 10.5 2.5 9.7 6.5 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 VDK85883.1 - 7.8 7.2 7.4 1.9 9.2 0.1 3.5 6 0 0 6 6 4 0 Tetratricopeptide repeat FCH PF00611.23 VDK85884.1 - 2e-16 60.1 0.8 2e-16 60.1 0.8 2.5 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain HR1 PF02185.16 VDK85884.1 - 2.1e-10 40.6 1.8 2.1e-10 40.6 1.8 2.5 2 1 1 3 3 3 1 Hr1 repeat SH3_1 PF00018.28 VDK85884.1 - 1.9e-08 33.8 0.0 3.5e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK85884.1 - 1.4e-05 24.8 0.1 2.3e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain Dynamitin PF04912.14 VDK85884.1 - 0.00039 19.9 9.0 0.00079 18.9 0.2 3.2 2 1 1 3 3 3 1 Dynamitin SH3_3 PF08239.11 VDK85884.1 - 0.016 15.5 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain SpmSyn_N PF17950.1 VDK85884.1 - 0.052 13.7 0.5 18 5.6 0.0 2.7 2 0 0 2 2 2 0 S-adenosylmethionine decarboxylase N -terminal DUF2408 PF10303.9 VDK85884.1 - 0.28 11.8 7.3 1.3 9.6 3.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) Peptidase_C13 PF01650.18 VDK85895.1 - 1.2e-33 116.7 0.4 1.6e-33 116.3 0.4 1.1 1 0 0 1 1 1 1 Peptidase C13 family LSM PF01423.22 VDK85896.1 - 1.2e-15 56.9 1.2 1.5e-15 56.6 1.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 VDK85896.1 - 0.0067 16.0 0.0 0.0092 15.6 0.0 1.4 1 0 0 1 1 1 1 Hfq protein DUF777 PF05606.11 VDK85896.1 - 0.04 13.7 0.8 0.051 13.3 0.8 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF777) TMIE PF16038.5 VDK85897.1 - 7.9e-14 51.3 7.4 7.5e-12 44.9 7.4 2.2 1 1 0 1 1 1 1 TMIE protein HECT PF00632.25 VDK85899.1 - 2.7e-92 309.5 0.1 4.9e-92 308.7 0.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 VDK85899.1 - 0.0051 16.5 0.4 0.13 12.2 0.1 3.0 3 0 0 3 3 3 1 IQ calmodulin-binding motif ARID PF01388.21 VDK85899.1 - 0.019 15.6 0.0 0.9 10.2 0.0 2.9 2 0 0 2 2 2 0 ARID/BRIGHT DNA binding domain DUF3072 PF11272.8 VDK85902.1 - 0.14 12.1 0.9 0.75 9.7 0.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3072) Ecotin PF03974.13 VDK85902.1 - 0.19 11.7 2.0 0.24 11.4 0.1 2.1 2 1 0 2 2 2 0 Ecotin AAA_6 PF12774.7 VDK85907.1 - 4.1e-128 426.9 0.7 6.5e-126 419.7 0.0 3.4 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_9 PF12781.7 VDK85907.1 - 3.9e-64 215.8 3.4 3.9e-64 215.8 3.4 3.6 4 0 0 4 4 4 1 ATP-binding dynein motor region DHC_N2 PF08393.13 VDK85907.1 - 1.4e-59 202.2 0.3 1.4e-59 202.2 0.3 4.1 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 VDK85907.1 - 1.7e-40 139.0 0.8 1.8e-39 135.7 0.0 3.1 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 AAA_lid_11 PF18198.1 VDK85907.1 - 1.9e-35 122.1 0.7 6.1e-35 120.5 0.1 2.3 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 VDK85907.1 - 5.4e-35 120.4 0.0 8.9e-22 77.6 0.0 5.9 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 VDK85907.1 - 7.6e-30 103.5 4.9 5.8e-29 100.6 0.1 4.6 5 0 0 5 5 5 1 Dynein heavy chain region D6 P-loop domain Dynein_C PF18199.1 VDK85907.1 - 2.5e-29 102.5 0.4 2.5e-29 102.5 0.4 2.9 2 1 0 2 2 2 1 Dynein heavy chain C-terminal domain MT PF12777.7 VDK85907.1 - 1.5e-23 83.4 13.2 1.3e-22 80.4 13.2 2.2 1 1 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 VDK85907.1 - 9.8e-23 80.6 0.0 8.5e-18 64.5 0.0 4.0 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_16 PF13191.6 VDK85907.1 - 8.8e-12 45.7 0.2 0.099 13.0 0.0 5.9 5 1 0 5 5 4 3 AAA ATPase domain AAA PF00004.29 VDK85907.1 - 6.7e-09 36.3 0.0 0.047 14.1 0.0 5.2 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 VDK85907.1 - 7.5e-08 32.7 6.8 0.66 10.2 0.0 7.6 8 0 0 8 8 6 2 AAA domain Rad17 PF03215.15 VDK85907.1 - 1.9e-06 27.9 0.1 0.17 11.8 0.0 3.7 3 0 0 3 3 3 2 Rad17 P-loop domain AAA_18 PF13238.6 VDK85907.1 - 2.4e-06 28.1 0.0 0.046 14.3 0.0 4.4 4 0 0 4 4 3 1 AAA domain RsgA_GTPase PF03193.16 VDK85907.1 - 4.5e-06 26.7 0.1 0.021 14.7 0.0 3.1 3 0 0 3 3 2 2 RsgA GTPase AAA_lid_1 PF17857.1 VDK85907.1 - 5.7e-06 26.5 0.7 2.3e-05 24.6 0.1 2.4 2 0 0 2 2 1 1 AAA+ lid domain ABC_tran PF00005.27 VDK85907.1 - 1.1e-05 26.0 5.6 0.013 16.0 0.0 5.3 6 0 0 6 6 5 1 ABC transporter ATPase_2 PF01637.18 VDK85907.1 - 3.9e-05 23.7 1.1 0.055 13.4 0.0 4.9 3 1 1 4 4 4 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 VDK85907.1 - 9.1e-05 22.8 0.1 0.82 10.1 0.0 4.3 4 0 0 4 4 4 1 RNA helicase AAA_24 PF13479.6 VDK85907.1 - 0.0002 21.1 0.0 0.11 12.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK85907.1 - 0.0003 20.6 0.2 1.3 8.7 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_29 PF13555.6 VDK85907.1 - 0.0013 18.4 0.0 0.075 12.8 0.0 3.1 3 0 0 3 3 2 1 P-loop containing region of AAA domain AAA_lid_7 PF17867.1 VDK85907.1 - 0.004 17.3 0.8 0.025 14.8 0.1 2.7 2 0 0 2 2 2 1 Midasin AAA lid domain T2SSE PF00437.20 VDK85907.1 - 0.0092 15.1 0.0 0.59 9.1 0.0 3.4 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_33 PF13671.6 VDK85907.1 - 0.01 16.0 0.1 3.5 7.8 0.0 4.2 4 0 0 4 4 3 0 AAA domain IstB_IS21 PF01695.17 VDK85907.1 - 0.017 14.8 0.1 3.1 7.5 0.0 3.1 3 0 0 3 3 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 VDK85907.1 - 0.017 14.8 0.0 1 9.1 0.0 3.2 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_28 PF13521.6 VDK85907.1 - 0.023 14.9 0.0 13 5.9 0.0 3.3 4 0 0 4 4 2 0 AAA domain Ribosomal_S7 PF00177.21 VDK85907.1 - 0.04 13.6 1.7 1.1 8.9 1.3 3.0 2 0 0 2 2 2 0 Ribosomal protein S7p/S5e AAA_23 PF13476.6 VDK85907.1 - 0.046 14.2 23.9 13 6.3 0.0 6.8 6 0 0 6 6 6 0 AAA domain Terminase_2 PF03592.16 VDK85907.1 - 0.061 13.8 1.6 0.4 11.2 1.6 2.5 1 0 0 1 1 1 0 Terminase small subunit Nup88 PF10168.9 VDK85907.1 - 1.1 7.0 19.7 0.43 8.3 8.8 2.9 2 0 0 2 2 2 0 Nuclear pore component G-alpha PF00503.20 VDK85907.1 - 1.2 8.2 6.4 0.22 10.6 0.0 3.1 4 0 0 4 4 4 0 G-protein alpha subunit YebO PF13974.6 VDK85907.1 - 1.6 8.9 4.9 3.2 7.9 0.7 3.1 2 0 0 2 2 2 0 YebO-like protein Caps_synth_GfcC PF06251.11 VDK85907.1 - 3.1 7.4 5.8 5.5 6.5 0.0 3.1 3 0 0 3 3 2 0 Capsule biosynthesis GfcC Suppressor_APC PF11414.8 VDK85907.1 - 6.3 6.9 6.8 1.9 8.6 1.6 3.0 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein VGLL4 PF15245.6 VDK85908.1 - 0.0025 17.9 5.8 0.36 10.9 1.5 3.0 2 1 0 2 2 2 2 Transcription cofactor vestigial-like protein 4 Vg_Tdu PF07545.14 VDK85908.1 - 0.021 14.6 0.1 1.4 8.7 0.1 2.3 2 0 0 2 2 2 0 Vestigial/Tondu family PI3_PI4_kinase PF00454.27 VDK85910.1 - 2.3e-31 109.5 0.0 7e-30 104.7 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Cyt-b5 PF00173.28 VDK85910.1 - 8.7e-23 80.3 0.0 1.8e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ATE_N PF04376.13 VDK85910.1 - 0.084 13.3 0.8 13 6.2 0.9 2.8 2 0 0 2 2 2 0 Arginine-tRNA-protein transferase, N terminus PI3_PI4_kinase PF00454.27 VDK85911.1 - 2.2e-31 109.6 0.0 6.8e-30 104.7 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Cyt-b5 PF00173.28 VDK85911.1 - 8.6e-23 80.3 0.0 1.7e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain IF4E PF01652.18 VDK85912.1 - 1.1e-50 171.5 0.0 1.5e-50 171.1 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E LepA_C PF06421.12 VDK85912.1 - 0.11 12.7 0.0 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 GTP-binding protein LepA C-terminus CH PF00307.31 VDK85918.1 - 2.5e-23 82.3 0.1 2.9e-23 82.1 0.1 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK85918.1 - 0.012 15.5 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain RhoGAP PF00620.27 VDK85919.1 - 9e-06 25.6 0.1 1.9e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain Glyco_transf_22 PF03901.17 VDK85920.1 - 3.6e-73 247.2 33.7 4.4e-73 246.9 33.7 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family SUI1 PF01253.22 VDK85920.1 - 6.9e-16 58.5 0.5 3.4e-08 33.9 0.2 2.3 2 0 0 2 2 2 2 Translation initiation factor SUI1 DUF1422 PF07226.11 VDK85920.1 - 8.4 6.5 8.8 0.84 9.7 3.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1422) Globin PF00042.22 VDK85921.1 - 1.7e-06 28.6 0.0 2.4e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Globin Ribosomal_L27A PF00828.19 VDK85924.1 - 1.9e-08 35.0 0.0 3.8e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A UBA_2 PF08587.11 VDK85924.1 - 0.0085 16.2 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) DUF4224 PF13986.6 VDK85924.1 - 0.66 9.9 3.2 22 5.0 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4224) SprT-like PF10263.9 VDK85925.1 - 1.9e-23 82.5 0.0 4.5e-23 81.3 0.0 1.6 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 VDK85925.1 - 2.1e-07 30.7 1.7 2.1e-07 30.7 1.7 2.6 3 0 0 3 3 3 1 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 VDK85925.1 - 0.02 15.0 0.3 0.065 13.4 0.3 1.9 1 0 0 1 1 1 0 Zinc ribbon domain GvpH PF05455.11 VDK85925.1 - 0.38 10.8 7.1 0.033 14.3 1.2 2.2 2 1 0 2 2 2 0 GvpH Fib_alpha PF08702.10 VDK85926.1 - 0.042 14.0 0.9 0.042 14.0 0.9 2.9 2 1 0 3 3 3 0 Fibrinogen alpha/beta chain family GAS PF13851.6 VDK85926.1 - 0.048 13.0 15.7 0.021 14.1 1.6 3.1 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding FUSC PF04632.12 VDK85926.1 - 0.065 11.8 0.3 0.087 11.3 0.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family YabA PF06156.13 VDK85926.1 - 8.3 7.1 11.7 1.6 9.4 1.1 3.2 3 2 0 3 3 3 0 Initiation control protein YabA Adenyl_transf PF04439.12 VDK85930.1 - 0.097 11.8 0.4 0.93 8.6 0.0 2.2 1 1 1 2 2 2 0 Streptomycin adenylyltransferase ARTD15_N PF18084.1 VDK85935.1 - 0.07 13.4 0.0 0.078 13.2 0.0 1.1 1 0 0 1 1 1 0 ARTD15 N-terminal domain Glyco_transf_92 PF01697.27 VDK85936.1 - 1.1e-39 136.7 7.3 1.1e-39 136.7 7.3 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 VDK85936.1 - 0.041 14.4 0.1 0.17 12.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 2 DUF1449 PF07290.11 VDK85938.1 - 0.097 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) ANF_receptor PF01094.28 VDK85939.1 - 6e-66 223.0 0.0 8.3e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 VDK85939.1 - 1.6e-21 77.1 18.3 3e-21 76.2 18.3 1.5 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR NCD3G PF07562.14 VDK85939.1 - 1.6e-09 37.6 14.3 1.6e-09 37.6 14.3 2.4 2 0 0 2 2 2 1 Nine Cysteines Domain of family 3 GPCR Peripla_BP_6 PF13458.6 VDK85939.1 - 0.00015 21.5 0.1 0.00026 20.8 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein SNF PF00209.18 VDK85941.1 - 2.8e-146 488.3 43.9 6.1e-146 487.2 43.9 1.5 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family P34-Arc PF04045.14 VDK85943.1 - 1.1e-97 326.5 0.0 1.4e-97 326.1 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Phage_int_SAM_5 PF13102.6 VDK85943.1 - 0.039 14.3 0.2 0.12 12.7 0.2 1.8 1 0 0 1 1 1 0 Phage integrase SAM-like domain Dynein_light PF01221.18 VDK85944.1 - 1.3e-40 137.6 1.0 1.4e-40 137.5 1.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ectatomin PF06457.11 VDK85944.1 - 0.13 12.2 0.2 0.2 11.6 0.2 1.3 1 0 0 1 1 1 0 Ectatomin NOA36 PF06524.12 VDK85945.1 - 0.17 11.2 16.0 0.24 10.7 16.0 1.2 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 VDK85945.1 - 3.7 7.6 11.8 4.3 7.4 11.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein RRN3 PF05327.11 VDK85945.1 - 6.2 5.2 9.4 7.5 5.0 9.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RRM_1 PF00076.22 VDK85947.1 - 0.007 16.2 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Alpha-2-MRAP_C PF06401.11 VDK85953.1 - 0.042 13.8 0.2 0.051 13.5 0.2 1.1 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF229 PF02995.17 VDK85954.1 - 1.9e-123 412.7 0.5 2.5e-123 412.3 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 VDK85954.1 - 0.00016 21.2 0.1 0.00031 20.2 0.1 1.5 1 1 0 1 1 1 1 Sulfatase DUF5106 PF17127.4 VDK85954.1 - 0.12 12.7 0.9 0.2 11.9 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5106) Prefoldin_2 PF01920.20 VDK85955.1 - 1.3e-19 70.1 3.5 1.5e-19 69.9 3.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit HMMR_N PF15905.5 VDK85955.1 - 0.005 16.4 4.3 0.0072 15.8 4.3 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal DASH_Dad2 PF08654.10 VDK85955.1 - 0.0075 16.7 2.9 0.39 11.2 0.2 2.2 2 0 0 2 2 2 1 DASH complex subunit Dad2 SKA2 PF16740.5 VDK85955.1 - 0.011 15.5 3.2 0.25 11.2 0.3 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 STAT_alpha PF01017.20 VDK85955.1 - 0.012 15.5 2.0 0.017 15.0 2.0 1.2 1 0 0 1 1 1 0 STAT protein, all-alpha domain Spc7 PF08317.11 VDK85955.1 - 0.012 14.5 4.3 0.015 14.2 4.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein RmuC PF02646.16 VDK85955.1 - 0.014 14.5 1.9 0.95 8.5 0.1 2.0 2 0 0 2 2 2 0 RmuC family DUF4795 PF16043.5 VDK85955.1 - 0.024 14.3 5.0 0.03 13.9 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Apolipoprotein PF01442.18 VDK85955.1 - 0.027 14.4 5.1 0.16 11.8 0.6 2.1 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Spc24 PF08286.11 VDK85955.1 - 0.032 14.5 5.5 0.67 10.2 0.9 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 HSCB_C PF07743.13 VDK85955.1 - 0.032 14.7 4.6 2.9 8.4 0.4 2.2 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain KxDL PF10241.9 VDK85955.1 - 0.034 14.4 3.6 3.3 8.1 0.2 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein Stathmin PF00836.19 VDK85955.1 - 0.035 14.1 0.8 0.035 14.1 0.8 1.9 2 0 0 2 2 2 0 Stathmin family YabA PF06156.13 VDK85955.1 - 0.036 14.7 4.1 1.5 9.5 0.2 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Phasin PF05597.11 VDK85955.1 - 0.041 13.9 0.9 0.36 10.8 0.1 2.0 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) YtxH PF12732.7 VDK85955.1 - 0.057 14.0 1.3 0.24 12.0 1.3 2.0 1 1 0 1 1 1 0 YtxH-like protein Fzo_mitofusin PF04799.13 VDK85955.1 - 0.058 13.0 3.2 2.5 7.6 0.2 2.1 2 0 0 2 2 2 0 fzo-like conserved region DXP_synthase_N PF13292.6 VDK85955.1 - 0.062 12.5 0.1 0.078 12.2 0.1 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase FliD_N PF02465.18 VDK85955.1 - 0.064 13.9 1.1 5.9 7.6 0.1 2.1 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF883 PF05957.13 VDK85955.1 - 0.065 13.8 1.5 1.6 9.3 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) YojJ PF10372.9 VDK85955.1 - 0.16 12.1 3.1 0.69 10.0 0.6 2.4 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Snapin_Pallidin PF14712.6 VDK85955.1 - 0.18 12.2 6.9 2.3 8.7 1.2 2.3 2 0 0 2 2 2 0 Snapin/Pallidin GHMP_kinases_C PF08544.13 VDK85955.1 - 0.2 12.0 0.8 3.5 8.1 0.1 2.3 2 1 0 2 2 2 0 GHMP kinases C terminal DASH_Dam1 PF08653.10 VDK85955.1 - 0.22 11.4 1.2 3.6 7.5 0.0 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 Med3 PF11593.8 VDK85955.1 - 0.24 10.5 2.7 0.3 10.2 0.3 1.9 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal GP41 PF00517.17 VDK85955.1 - 0.28 11.1 4.4 3.6 7.4 0.2 2.1 1 1 1 2 2 2 0 Retroviral envelope protein MtrG PF04210.13 VDK85955.1 - 0.3 11.0 0.8 0.61 10.0 0.1 1.9 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G LPP PF04728.13 VDK85955.1 - 0.63 10.5 4.8 1.7 9.1 0.4 2.7 2 1 0 2 2 2 0 Lipoprotein leucine-zipper XhlA PF10779.9 VDK85955.1 - 1 9.6 7.9 1.2 9.4 2.1 2.4 2 1 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 VDK85955.1 - 1.1 9.4 5.4 1.3 9.0 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Pup PF05639.11 VDK85955.1 - 1.1 10.2 9.4 3.4 8.6 1.7 2.3 2 0 0 2 2 2 0 Pup-like protein bZIP_1 PF00170.21 VDK85955.1 - 1.3 9.1 8.6 5.1 7.3 3.0 2.3 2 0 0 2 2 2 0 bZIP transcription factor DUF5595 PF18077.1 VDK85955.1 - 4.6 7.4 7.8 0.99 9.5 2.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) G6PD_C PF02781.16 VDK85956.1 - 1.2e-112 375.9 0.0 1.4e-112 375.6 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 VDK85956.1 - 2.6e-58 197.6 0.0 7.5e-58 196.1 0.0 1.7 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Ank_5 PF13857.6 VDK85963.1 - 4.8e-14 52.2 0.1 1.1e-10 41.5 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 VDK85963.1 - 1.2e-13 50.8 0.4 9.1e-06 25.9 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 VDK85963.1 - 2.5e-13 50.4 0.0 5.9e-13 49.2 0.0 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDK85963.1 - 8.1e-13 47.3 0.1 1.2e-05 25.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 VDK85963.1 - 4.7e-10 39.8 0.0 2.3e-09 37.6 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) BTB_2 PF02214.22 VDK85966.1 - 1.6e-15 57.2 0.0 3.1e-15 56.3 0.0 1.4 1 1 0 1 1 1 1 BTB/POZ domain VPS13 PF16908.5 VDK85966.1 - 0.028 14.2 0.0 0.034 13.9 0.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal MFS_1 PF07690.16 VDK85967.1 - 9.3e-38 130.0 27.4 3.8e-22 78.7 13.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily S1FA PF04689.13 VDK85967.1 - 0.12 12.5 0.8 24 5.1 0.7 2.8 2 0 0 2 2 2 0 DNA binding protein S1FA SpecificRecomb PF10136.9 VDK85967.1 - 0.18 10.1 4.0 0.35 9.1 4.0 1.4 1 0 0 1 1 1 0 Site-specific recombinase MFS_3 PF05977.13 VDK85967.1 - 1.6 7.0 9.9 0.11 10.8 0.4 2.5 2 1 0 2 2 2 0 Transmembrane secretion effector CBM_21 PF03370.13 VDK85971.1 - 2.2e-27 95.5 0.1 4.7e-27 94.4 0.1 1.6 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 VDK85971.1 - 2.1e-11 44.3 0.2 5.1e-11 43.0 0.2 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) CBAH PF02275.18 VDK85974.1 - 3.8e-13 49.8 0.4 1e-12 48.3 0.1 1.7 1 1 1 2 2 2 1 Linear amide C-N hydrolases, choloylglycine hydrolase family NAAA-beta PF15508.6 VDK85974.1 - 2.2e-11 43.9 2.5 4.4e-11 42.9 1.9 1.8 2 0 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase AAT PF03417.16 VDK85974.1 - 0.013 15.2 0.1 0.029 14.0 0.1 1.5 1 1 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase OmpH PF03938.14 VDK85975.1 - 0.011 16.0 2.0 0.011 16.0 2.0 11.7 2 2 10 12 12 12 0 Outer membrane protein (OmpH-like) PNP_UDP_1 PF01048.20 VDK85976.1 - 7.4e-18 64.6 0.3 2.3e-10 40.1 0.0 2.1 1 1 1 2 2 2 2 Phosphorylase superfamily AMNp_N PF10423.9 VDK85976.1 - 0.17 11.5 0.0 0.71 9.5 0.0 1.9 2 0 0 2 2 2 0 Bacterial AMP nucleoside phosphorylase N-terminus FAIM1 PF06905.13 VDK85977.1 - 2e-78 262.1 4.7 2.3e-78 261.9 4.7 1.0 1 0 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) IPP-2 PF04979.14 VDK85978.1 - 6.3e-05 23.7 7.0 0.019 15.7 0.3 2.2 1 1 1 2 2 2 2 Protein phosphatase inhibitor 2 (IPP-2) DMAP1 PF05499.12 VDK85991.1 - 2e-59 200.2 3.2 2.4e-59 199.9 1.7 1.9 2 0 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) SANT_DAMP1_like PF16282.5 VDK85991.1 - 2.7e-29 101.2 0.8 1.1e-28 99.2 0.4 2.2 2 0 0 2 2 2 1 SANT/Myb-like domain of DAMP1 FapA PF03961.13 VDK85991.1 - 0.98 7.9 4.0 1.5 7.3 1.9 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A CNRIP1 PF15043.6 VDK85993.1 - 2e-47 160.6 0.0 2.4e-47 160.4 0.0 1.0 1 0 0 1 1 1 1 CB1 cannabinoid receptor-interacting protein 1 LIM PF00412.22 VDK85994.1 - 2.3e-16 59.8 22.6 4.5e-08 33.2 4.3 2.5 2 0 0 2 2 2 2 LIM domain zf-BED PF02892.15 VDK85994.1 - 5.1e-09 36.0 0.2 5.1e-09 36.0 0.2 2.4 2 1 1 3 3 3 1 BED zinc finger WD40 PF00400.32 VDK85995.1 - 2.2e-27 94.8 6.3 1.2e-07 32.3 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK85995.1 - 2.6e-13 50.1 0.2 1.4e-05 25.3 0.0 4.5 2 2 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK85995.1 - 0.00045 20.2 0.0 0.035 14.0 0.0 2.7 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 VDK85995.1 - 0.079 10.9 0.0 8.2 4.3 0.0 2.3 2 0 0 2 2 2 0 IKI3 family PALB2_WD40 PF16756.5 VDK85995.1 - 0.11 11.4 0.2 2.3 7.1 0.0 2.1 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain QWRF PF04484.12 VDK85995.1 - 0.9 9.2 7.8 1.5 8.5 7.8 1.3 1 0 0 1 1 1 0 QWRF family Utp12 PF04003.12 VDK85996.1 - 2e-17 63.4 0.4 3.3e-17 62.8 0.4 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ERAP1_C PF11838.8 VDK86001.1 - 1.6e-09 37.8 0.0 1.8e-09 37.6 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain CAF1C_H4-bd PF12265.8 VDK86003.1 - 2.7e-29 101.2 1.5 2.2e-28 98.3 0.5 2.7 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 VDK86003.1 - 2e-28 98.1 12.7 1.7e-07 31.8 0.0 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK86003.1 - 9e-06 25.9 0.3 0.011 16.0 0.0 3.8 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 VDK86003.1 - 2.1e-05 24.5 2.2 0.02 14.8 0.1 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Isy1 PF06246.12 VDK86004.1 - 1.8e-84 283.3 10.0 2e-84 283.1 10.0 1.0 1 0 0 1 1 1 1 Isy1-like splicing family Spec3 PF15795.5 VDK86005.1 - 3.8e-31 107.5 8.2 5.7e-31 106.9 8.2 1.3 1 0 0 1 1 1 1 Ectodermal ciliogenesis protein Acyl_transf_3 PF01757.22 VDK86006.1 - 1.3e-20 73.8 45.8 5.2e-20 71.8 44.5 2.0 2 0 0 2 2 2 1 Acyltransferase family DNA_pol_E_B PF04042.16 VDK86006.1 - 0.0028 17.0 0.0 0.0058 16.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B GPR15L PF15854.5 VDK86006.1 - 0.0098 16.1 0.1 0.052 13.8 0.1 2.3 1 0 0 1 1 1 1 G-protein coupled receptor ligand 15 UPF0542 PF15086.6 VDK86006.1 - 0.039 13.9 0.3 0.82 9.7 0.2 2.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 TMEM100 PF16311.5 VDK86006.1 - 0.065 12.8 0.1 0.25 10.9 0.1 2.0 1 0 0 1 1 1 0 Transmembrane protein 100 Auts2 PF15336.6 VDK86010.1 - 0.0075 16.4 6.9 0.0075 16.4 6.9 4.6 3 1 1 5 5 5 1 Autism susceptibility gene 2 protein YmgB PF10798.8 VDK86015.1 - 0.11 12.3 1.3 0.34 10.8 0.5 1.9 1 1 1 2 2 2 0 Biofilm development protein YmgB/AriR DUF5632 PF18646.1 VDK86016.1 - 0.072 13.2 0.0 0.26 11.3 0.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5632) DEAD PF00270.29 VDK86018.1 - 5.3e-42 143.6 0.0 9.1e-42 142.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK86018.1 - 2.3e-31 108.4 0.0 1.7e-30 105.6 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK86018.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit SP_C-Propep PF08999.10 VDK86018.1 - 4.3 7.2 6.4 9 6.2 6.4 1.4 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Motile_Sperm PF00635.26 VDK86019.1 - 2.3e-11 43.5 0.1 2.7e-11 43.3 0.1 1.2 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 VDK86019.1 - 0.034 14.3 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PAS_11 PF14598.6 VDK86036.1 - 4.1e-20 72.0 0.3 4.6e-14 52.5 0.2 3.0 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 VDK86036.1 - 2.6e-15 56.5 0.0 2.2e-09 37.4 0.0 3.2 3 0 0 3 3 3 2 PAS fold PAS PF00989.25 VDK86036.1 - 5.4e-12 45.7 0.0 3.9e-06 26.9 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 VDK86036.1 - 8.2e-07 29.2 0.0 0.0024 18.1 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 VDK86036.1 - 0.00011 22.4 0.0 0.043 14.1 0.0 2.8 3 0 0 3 3 3 2 PAS fold UPF0020 PF01170.18 VDK86037.1 - 1.2e-05 25.1 0.0 0.0028 17.4 0.0 2.8 2 1 1 3 3 3 2 Putative RNA methylase family UPF0020 AviRa PF11599.8 VDK86037.1 - 0.1 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa AAA_lid_11 PF18198.1 VDK86037.1 - 0.13 12.1 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Dynein heavy chain AAA lid domain SH3_9 PF14604.6 VDK86038.1 - 1.1e-08 34.8 0.0 2.8e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK86038.1 - 0.00019 20.9 0.2 0.00064 19.3 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 VDK86038.1 - 0.00033 20.3 0.2 0.00081 19.0 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain NodZ PF05830.11 VDK86038.1 - 0.014 14.3 0.0 0.035 12.9 0.0 1.6 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) TRAPPC-Trs85 PF12739.7 VDK86042.1 - 6e-93 312.0 0.4 8.1e-93 311.6 0.4 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit ArfGap PF01412.18 VDK86044.1 - 2e-32 111.7 0.2 4.8e-32 110.5 0.2 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF4199 PF13858.6 VDK86045.1 - 0.014 15.8 1.0 0.024 15.0 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) FA_desaturase PF00487.24 VDK86045.1 - 0.07 13.0 0.3 0.084 12.7 0.3 1.2 1 0 0 1 1 1 0 Fatty acid desaturase Suv3_N PF18114.1 VDK86048.1 - 0.013 15.6 0.7 0.031 14.4 0.1 1.9 2 0 0 2 2 2 0 Suv3 helical N-terminal domain PolyA_pol_arg_C PF12626.7 VDK86048.1 - 0.015 15.3 1.6 0.015 15.3 1.6 1.9 2 0 0 2 2 2 0 Polymerase A arginine-rich C-terminus GrpE PF01025.19 VDK86048.1 - 0.49 10.0 6.3 0.7 9.5 5.3 1.8 1 1 0 1 1 1 0 GrpE TSNAXIP1_N PF15739.5 VDK86048.1 - 0.89 10.0 8.4 1.6 9.1 0.3 2.6 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus DUF836 PF05768.14 VDK86048.1 - 1.5 9.3 3.6 3.6 8.1 0.3 2.5 2 1 0 2 2 2 0 Glutaredoxin-like domain (DUF836) SlyX PF04102.12 VDK86048.1 - 5.8 7.6 7.3 1.5 9.5 1.0 2.9 3 0 0 3 3 3 0 SlyX zf-CCCH PF00642.24 VDK86051.1 - 3.5e-09 36.3 23.1 0.0003 20.6 3.5 3.3 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDK86051.1 - 9.2e-06 25.5 27.9 0.00087 19.3 6.3 3.8 3 1 0 3 3 3 2 Zinc finger domain zf-CCCH_3 PF15663.5 VDK86051.1 - 0.00078 19.6 11.3 0.0019 18.4 2.4 2.3 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 VDK86051.1 - 0.015 15.1 4.3 0.015 15.1 4.3 3.7 4 0 0 4 4 4 0 CCCH-type zinc finger Torus PF16131.5 VDK86051.1 - 0.075 13.7 21.2 0.07 13.8 1.4 3.8 2 1 2 4 4 4 0 Torus domain PAP2_C PF14360.6 VDK86052.1 - 8.7e-25 87.1 9.7 8.7e-25 87.1 9.7 2.7 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 VDK86052.1 - 2e-07 30.9 5.3 2e-07 30.9 5.3 2.3 2 1 0 2 2 2 1 PAP2 superfamily Helicase_C PF00271.31 VDK86056.1 - 3.8e-24 85.2 1.2 1.1e-23 83.7 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 VDK86056.1 - 3.4e-14 53.0 0.0 8.4e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C_2 PF13307.6 VDK86056.1 - 0.0046 17.1 0.1 0.21 11.7 0.0 2.7 1 1 1 2 2 2 1 Helicase C-terminal domain AAA_22 PF13401.6 VDK86056.1 - 0.037 14.3 0.3 0.43 10.8 0.0 2.8 2 1 0 2 2 2 0 AAA domain PUB PF09409.10 VDK86058.1 - 1.1e-24 86.2 0.2 2e-24 85.3 0.2 1.5 1 0 0 1 1 1 1 PUB domain UBX PF00789.20 VDK86058.1 - 2.2e-07 31.0 0.0 7.7e-07 29.2 0.0 2.0 2 0 0 2 2 2 1 UBX domain HGD-D PF06050.13 VDK86058.1 - 0.12 12.1 0.1 0.32 10.7 0.1 1.6 2 0 0 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component RRM_1 PF00076.22 VDK86059.1 - 8.1e-14 51.2 0.0 1.3e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 VDK86059.1 - 0.0023 17.9 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 RNA binding domain GRP PF07172.11 VDK86059.1 - 6.1 7.6 34.9 22 5.8 34.9 1.9 1 1 0 1 1 1 0 Glycine rich protein family NAP PF00956.18 VDK86061.1 - 6.4e-88 294.4 5.5 7.7e-88 294.2 5.5 1.1 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Fib_alpha PF08702.10 VDK86061.1 - 0.067 13.4 0.1 0.19 11.9 0.0 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Ground-like PF04155.18 VDK86062.1 - 2.8e-11 43.9 0.6 3e-11 43.8 0.6 1.0 1 0 0 1 1 1 1 Ground-like domain Sugar_tr PF00083.24 VDK86069.1 - 1.9e-105 353.4 29.4 2.1e-105 353.2 29.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK86069.1 - 9.5e-19 67.5 31.7 9.5e-19 67.5 31.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ECH_1 PF00378.20 VDK86072.1 - 1.3e-39 136.0 0.0 8.6e-39 133.4 0.0 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 VDK86072.1 - 7.2e-23 81.6 0.0 3.8e-22 79.2 0.0 1.8 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase adh_short PF00106.25 VDK86074.1 - 6.8e-37 126.8 0.2 1.1e-36 126.2 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK86074.1 - 8.2e-33 113.9 0.2 1.7e-32 112.9 0.2 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 VDK86074.1 - 5.1e-13 49.4 0.0 8.9e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 VDK86074.1 - 2.2e-06 27.7 0.4 3.9e-06 26.9 0.4 1.3 1 0 0 1 1 1 1 KR domain CBFD_NFYB_HMF PF00808.23 VDK86075.1 - 1.7e-12 47.4 0.0 2.8e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK86075.1 - 2.9e-06 27.7 0.1 4.4e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Aldedh PF00171.22 VDK86076.1 - 1.4e-149 498.5 0.3 1.7e-149 498.3 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3692 PF12469.8 VDK86076.1 - 0.15 12.3 0.0 0.45 10.7 0.0 1.9 2 0 0 2 2 2 0 CRISPR-associated protein Membr_traf_MHD PF10540.9 VDK86084.1 - 2.7e-33 115.2 0.4 6.4e-33 114.0 0.4 1.6 1 0 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 VDK86084.1 - 1.4e-12 47.8 0.0 3.5e-12 46.5 0.0 1.7 2 0 0 2 2 2 1 C2 domain TPX2 PF06886.11 VDK86089.1 - 0.05 13.8 3.7 0.07 13.4 3.7 1.1 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Ank_2 PF12796.7 VDK86090.1 - 2.2e-30 105.1 0.4 7.7e-17 61.7 0.4 2.8 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK86090.1 - 3.6e-28 97.3 8.8 1.9e-10 40.8 1.0 4.5 2 2 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 VDK86090.1 - 2.6e-26 90.9 9.5 4.2e-08 33.3 0.3 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_4 PF13637.6 VDK86090.1 - 9.8e-23 80.2 6.6 4.2e-12 46.3 0.3 5.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK86090.1 - 4.7e-22 75.7 4.7 1.9e-05 24.7 0.1 5.6 5 0 0 5 5 5 4 Ankyrin repeat Imm49 PF15575.6 VDK86090.1 - 0.084 12.6 2.9 0.74 9.5 0.1 2.7 3 0 0 3 3 3 0 Immunity protein 49 Globin PF00042.22 VDK86091.1 - 3.4e-08 34.0 0.1 2.3e-07 31.4 0.1 2.0 1 1 1 2 2 2 1 Globin RAWUL PF16207.5 VDK86092.1 - 8.6e-08 32.7 0.0 2.1e-07 31.5 0.0 1.7 1 0 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4 PF00097.25 VDK86092.1 - 4.7e-06 26.4 8.5 9.5e-06 25.4 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK86092.1 - 0.0022 18.0 5.4 0.0054 16.7 5.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDK86092.1 - 0.0046 16.8 10.9 0.0097 15.7 10.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 VDK86092.1 - 0.035 14.3 8.1 0.093 12.9 8.1 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 VDK86092.1 - 0.061 13.3 10.2 0.14 12.2 10.2 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-Nse PF11789.8 VDK86092.1 - 0.24 11.3 1.9 0.49 10.2 1.9 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.6 VDK86092.1 - 0.28 11.1 8.9 0.53 10.2 8.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 VDK86092.1 - 1.1 9.1 5.1 2.4 8.1 5.1 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 VDK86092.1 - 7.8 6.9 9.8 18 5.7 9.8 1.6 1 0 0 1 1 1 0 Ring finger domain Pkinase PF00069.25 VDK86094.1 - 8e-09 35.2 0.0 1.5e-08 34.3 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain HAGH_C PF16123.5 VDK86097.1 - 4e-17 62.5 0.0 1e-16 61.2 0.0 1.7 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 VDK86097.1 - 4e-14 53.1 0.3 3e-13 50.2 0.3 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 VDK86097.1 - 0.00089 18.8 0.1 0.0019 17.7 0.1 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Ly-6_related PF06579.12 VDK86098.1 - 9.5e-23 80.8 6.5 1.6e-13 51.0 1.2 2.2 1 1 1 2 2 2 2 Caenorhabditis elegans ly-6-related protein SLC12 PF03522.15 VDK86099.1 - 2.2 7.2 19.2 2.6 6.9 19.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MCM_bind PF09739.9 VDK86099.1 - 4.3 5.7 17.7 5 5.4 17.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CDC27 PF09507.10 VDK86099.1 - 5.1 6.4 37.5 6.1 6.1 37.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 BTB PF00651.31 VDK86100.1 - 4.2e-26 91.4 0.2 1.3e-25 89.8 0.1 1.8 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 VDK86100.1 - 0.00079 19.5 0.2 0.013 15.6 0.1 2.3 1 1 1 2 2 2 1 BTB And C-terminal Kelch Exo_endo_phos PF03372.23 VDK86101.1 - 1.1e-09 38.2 0.1 1.5e-09 37.8 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family COX6B PF02297.17 VDK86104.1 - 1.4e-11 44.5 3.9 1.4e-11 44.5 3.9 1.9 2 0 0 2 2 2 1 Cytochrome oxidase c subunit VIb DB PF01682.19 VDK86105.1 - 1.5e-05 25.2 0.9 2e-05 24.8 0.9 1.1 1 0 0 1 1 1 1 DB module DUF4819 PF16090.5 VDK86106.1 - 1.7e-15 56.8 0.3 7.7e-15 54.8 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4819) TGF_beta PF00019.20 VDK86110.1 - 1.8e-26 93.1 0.0 3.1e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 Transforming growth factor beta like domain TGFb_propeptide PF00688.18 VDK86110.1 - 5.4e-15 55.8 0.0 8.7e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 TGF-beta propeptide TPR_1 PF00515.28 VDK86111.1 - 1.6e-48 160.6 20.1 1.7e-10 40.3 0.7 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 VDK86111.1 - 5.4e-39 129.2 16.7 9.3e-10 37.9 0.4 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 VDK86111.1 - 9.7e-26 89.2 14.1 1.8e-10 40.3 0.0 5.5 4 1 1 5 5 5 3 TPR repeat TPR_12 PF13424.6 VDK86111.1 - 1.4e-22 79.7 10.1 2.1e-09 37.5 0.1 5.2 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDK86111.1 - 1.2e-21 75.0 19.2 0.00023 21.1 0.1 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 VDK86111.1 - 6.3e-21 73.3 5.1 0.00022 21.8 0.0 7.0 2 2 6 8 8 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 VDK86111.1 - 9.9e-21 74.1 3.1 1.7e-06 28.5 0.0 4.4 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 VDK86111.1 - 1.2e-20 73.7 7.4 7.5e-05 23.2 0.0 4.6 4 1 1 5 5 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 VDK86111.1 - 5.2e-19 67.2 14.3 7.1e-07 29.2 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 VDK86111.1 - 3.8e-16 57.8 6.4 0.0013 18.6 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat STI1 PF17830.1 VDK86111.1 - 5.3e-15 55.1 1.1 2.2e-14 53.1 0.3 2.5 3 0 0 3 3 2 1 STI1 domain TPR_10 PF13374.6 VDK86111.1 - 1.6e-13 50.0 10.6 0.021 14.7 0.2 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK86111.1 - 8.9e-11 41.9 7.8 6.3e-06 26.3 1.3 3.2 2 2 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 VDK86111.1 - 3.3e-08 33.5 10.0 0.14 12.3 0.0 5.4 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 VDK86111.1 - 3.7e-07 30.2 0.8 0.0045 17.1 0.0 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 VDK86111.1 - 1.4e-05 25.4 13.5 1.5 9.6 0.0 6.0 7 0 0 7 7 5 2 Tetratricopeptide repeat NARP1 PF12569.8 VDK86111.1 - 1.9e-05 23.8 7.9 0.0032 16.5 0.5 3.2 1 1 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 VDK86111.1 - 2.3e-05 23.8 1.6 0.054 12.7 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 VDK86111.1 - 0.00057 19.7 12.0 0.38 10.4 0.0 4.1 1 1 2 4 4 4 1 Tetratricopeptide repeat-like domain SHNi-TPR PF10516.9 VDK86111.1 - 0.014 14.9 4.1 0.46 10.0 0.1 3.8 5 0 0 5 5 5 0 SHNi-TPR RNase_T PF00929.24 VDK86111.1 - 0.018 15.6 0.9 0.26 11.8 0.1 2.5 1 1 0 2 2 2 0 Exonuclease BTAD PF03704.17 VDK86111.1 - 0.043 14.3 2.2 15 6.0 0.0 3.3 2 1 1 3 3 3 0 Bacterial transcriptional activator domain MIT PF04212.18 VDK86111.1 - 0.11 12.6 18.6 4.6 7.4 0.0 5.6 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 VDK86111.1 - 0.12 12.6 5.4 14 6.2 0.0 4.9 6 0 0 6 6 4 0 PPR repeat Coatomer_E PF04733.14 VDK86111.1 - 0.29 10.5 4.8 4.1 6.7 0.3 3.1 2 2 1 3 3 3 0 Coatomer epsilon subunit Alkyl_sulf_dimr PF14863.6 VDK86111.1 - 1.5 9.3 5.7 23 5.4 0.1 3.5 3 1 0 3 3 3 0 Alkyl sulfatase dimerisation SPO22 PF08631.10 VDK86111.1 - 1.5 8.2 5.3 22 4.4 0.1 3.5 4 0 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like Rad51 PF08423.11 VDK86113.1 - 6.7e-108 359.8 0.2 4.4e-104 347.3 0.2 2.1 1 1 0 1 1 1 1 Rad51 HHH_5 PF14520.6 VDK86113.1 - 1.1e-10 42.0 0.3 2.4e-10 40.9 0.3 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_25 PF13481.6 VDK86113.1 - 1e-09 38.3 0.0 1.5e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 VDK86113.1 - 1.3e-06 28.0 0.0 2.5e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 VDK86113.1 - 0.00062 19.2 0.5 0.013 14.9 0.2 2.3 2 0 0 2 2 2 1 KaiC HhH-GPD PF00730.25 VDK86113.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.6 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein AAA_24 PF13479.6 VDK86113.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK86113.1 - 0.085 13.1 0.2 0.4 11.0 0.2 2.0 1 1 0 1 1 1 0 AAA domain QVR PF17064.5 VDK86119.1 - 0.59 10.4 9.1 15 5.9 9.1 2.6 1 1 0 1 1 1 0 Sleepless protein Pkinase PF00069.25 VDK86120.1 - 3.2e-23 82.5 0.0 4.5e-23 81.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86120.1 - 3.8e-10 39.5 0.0 4.9e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK86120.1 - 0.12 11.1 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase M_domain PF12938.7 VDK86121.1 - 2.1e-05 24.4 12.0 2.1e-05 24.4 12.0 5.8 5 2 2 7 7 7 1 M domain of GW182 Beta-Casp PF10996.8 VDK86122.1 - 4.9e-32 110.5 0.0 8.7e-32 109.7 0.0 1.4 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 VDK86122.1 - 1.6e-18 66.9 0.0 1.1e-17 64.1 0.0 2.0 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 VDK86122.1 - 5.9e-18 64.6 0.0 1.2e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 VDK86122.1 - 2.1e-16 60.5 0.0 3.1e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 VDK86122.1 - 1.2e-07 31.4 0.2 8.7e-07 28.6 0.0 2.2 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 VDK86122.1 - 1.3e-05 25.2 0.0 3.7e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 VDK86122.1 - 0.00022 20.5 0.0 0.00044 19.6 0.0 1.4 1 0 0 1 1 1 1 Putative beta-lactamase-like family CAP_N PF01213.19 VDK86123.1 - 0.0017 17.9 4.5 0.0017 17.9 4.5 1.5 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal DUF3123 PF11321.8 VDK86123.1 - 0.45 11.2 4.7 0.19 12.4 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Mito_fiss_reg PF05308.11 VDK86123.1 - 0.53 10.3 6.2 0.24 11.5 3.3 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator PRIMA1 PF16101.5 VDK86125.1 - 0.001 19.1 4.2 0.0011 18.9 4.2 1.2 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 MGC-24 PF05283.11 VDK86125.1 - 0.16 12.4 2.7 0.18 12.2 2.7 1.1 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Mito_fiss_reg PF05308.11 VDK86125.1 - 0.21 11.7 5.2 0.22 11.6 5.2 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 VDK86125.1 - 0.23 10.9 8.0 0.25 10.8 8.0 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TALPID3 PF15324.6 VDK86125.1 - 1 6.9 8.4 1.2 6.7 8.4 1.0 1 0 0 1 1 1 0 Hedgehog signalling target DEC-1_N PF04625.13 VDK86125.1 - 2.7 6.9 6.7 2.9 6.8 6.7 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region LRR_8 PF13855.6 VDK86126.1 - 5.8e-14 51.6 24.5 2.4e-08 33.6 4.9 4.8 3 3 2 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 VDK86126.1 - 4.5e-09 36.4 24.9 0.0065 16.9 3.0 5.3 2 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDK86126.1 - 0.00018 21.0 6.8 0.1 12.1 3.1 2.7 1 1 0 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 VDK86126.1 - 0.0017 18.6 23.3 4 8.3 0.5 6.8 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 VDK86126.1 - 1 9.6 12.6 14 6.1 0.1 5.4 5 0 0 5 5 5 0 Leucine Rich repeat Paf1 PF03985.13 VDK86129.1 - 2.4e-130 435.3 14.1 2.4e-130 435.3 14.1 1.9 1 1 1 2 2 2 1 Paf1 GYF PF02213.16 VDK86131.1 - 5.5e-15 54.8 0.8 1e-14 53.9 0.8 1.5 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 VDK86131.1 - 0.0037 17.0 0.2 0.0091 15.8 0.2 1.7 1 0 0 1 1 1 1 GYF domain 2 UAA PF08449.11 VDK86134.1 - 4.2e-07 29.5 3.2 6.8e-07 28.8 3.2 1.3 1 0 0 1 1 1 1 UAA transporter family Kinesin PF00225.23 VDK86135.1 - 1.2e-76 257.8 0.2 2.3e-70 237.2 0.1 2.4 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 VDK86135.1 - 3.8e-27 95.1 0.1 1.1e-26 93.6 0.1 1.8 1 0 0 1 1 1 1 Microtubule binding PAC3 PF10178.9 VDK86135.1 - 0.14 12.3 0.0 0.35 11.0 0.0 1.6 1 0 0 1 1 1 0 Proteasome assembly chaperone 3 V_ATPase_I PF01496.19 VDK86135.1 - 0.41 8.5 11.6 0.72 7.7 11.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family APG6_N PF17675.1 VDK86135.1 - 1 9.9 36.8 0.79 10.2 13.7 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region PIP5K PF01504.18 VDK86136.1 - 1e-71 241.4 0.0 1.4e-71 240.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Syntaxin PF00804.25 VDK86137.1 - 3.3e-59 199.9 11.8 3.2e-57 193.5 11.8 2.2 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 VDK86137.1 - 3.3e-14 52.6 0.6 3.6e-13 49.3 0.1 2.8 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 VDK86137.1 - 5.3e-09 36.4 1.5 5.3e-09 36.4 1.5 2.7 2 2 0 2 2 2 1 Syntaxin-like protein SIMPL PF04402.14 VDK86137.1 - 0.016 15.6 2.4 0.042 14.3 2.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF541) MCPsignal PF00015.21 VDK86137.1 - 0.055 13.3 5.4 0.54 10.0 0.2 3.1 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain PAPS_reduct PF01507.19 VDK86137.1 - 0.077 13.0 2.3 0.63 10.1 0.1 2.7 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family Occludin_ELL PF07303.13 VDK86137.1 - 0.28 11.9 6.0 0.87 10.4 0.5 2.8 2 1 1 3 3 3 0 Occludin homology domain DUF2205 PF10224.9 VDK86137.1 - 0.77 9.8 4.8 0.87 9.6 0.1 3.1 3 1 0 3 3 3 0 Short coiled-coil protein DUF2508 PF10704.9 VDK86137.1 - 0.83 9.9 4.4 0.67 10.2 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2508) YabA PF06156.13 VDK86137.1 - 1.6 9.4 7.6 4.3 8.0 0.3 3.2 3 1 0 3 3 3 0 Initiation control protein YabA Prefoldin PF02996.17 VDK86137.1 - 2.9 7.8 7.8 8.4 6.3 0.1 3.9 4 0 0 4 4 4 0 Prefoldin subunit HAUS6_N PF14661.6 VDK86137.1 - 5.5 6.5 7.2 5.5 6.5 4.2 2.4 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Fez1 PF06818.15 VDK86137.1 - 5.7 7.3 11.2 1.4 9.4 0.5 2.7 2 1 1 3 3 3 0 Fez1 DUF148 PF02520.17 VDK86137.1 - 7.8 6.7 8.0 2.8 8.1 0.2 3.2 3 1 1 4 4 4 0 Domain of unknown function DUF148 ERp29 PF07749.12 VDK86137.1 - 7.8 7.5 8.8 0.57 11.1 1.5 2.8 3 2 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain LRR_8 PF13855.6 VDK86146.1 - 5.9e-38 128.4 43.5 1.3e-14 53.7 6.5 7.6 4 3 3 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 VDK86146.1 - 3.8e-24 84.4 46.5 1.4e-05 25.4 4.7 9.0 4 2 6 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK86146.1 - 5.9e-12 44.4 37.7 1.5 9.6 0.0 12.9 12 2 1 13 13 13 3 Leucine Rich Repeat LRR_5 PF13306.6 VDK86146.1 - 5.4e-08 32.8 0.1 0.0017 18.3 0.0 3.5 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 VDK86146.1 - 2.3e-07 30.3 37.2 0.45 10.7 0.7 12.2 14 0 0 14 14 14 3 Leucine Rich repeat LRR_9 PF14580.6 VDK86146.1 - 1.7e-06 27.7 15.3 0.014 14.9 1.6 4.3 1 1 2 4 4 4 4 Leucine-rich repeat LRR_2 PF07723.13 VDK86146.1 - 0.044 14.5 0.9 2.8 8.7 0.0 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat LRRNT PF01462.18 VDK86146.1 - 0.054 13.2 0.7 0.054 13.2 0.7 2.3 3 0 0 3 3 3 0 Leucine rich repeat N-terminal domain LRR_12 PF18837.1 VDK86146.1 - 0.89 9.3 8.9 1.7 8.3 0.1 5.2 5 0 0 5 5 5 0 Leucine-rich repeat LysE PF01810.18 VDK86147.1 - 0.033 13.7 0.0 0.042 13.3 0.0 1.1 1 0 0 1 1 1 0 LysE type translocator Rab5ip PF07019.12 VDK86147.1 - 0.05 14.2 0.2 0.068 13.8 0.2 1.2 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) LapA_dom PF06305.11 VDK86147.1 - 0.057 13.2 0.2 0.097 12.5 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain SieB PF14163.6 VDK86147.1 - 0.11 12.0 0.4 0.21 11.1 0.4 1.3 1 0 0 1 1 1 0 Super-infection exclusion protein B DUF2681 PF10883.8 VDK86147.1 - 0.14 12.6 0.2 0.22 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Tad PF13400.6 VDK86147.1 - 0.15 12.4 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like DUF1844 PF08899.11 VDK86148.1 - 0.094 13.0 0.2 0.18 12.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1844) GA PF01468.17 VDK86148.1 - 0.19 12.0 0.1 0.19 12.0 0.1 2.0 2 0 0 2 2 2 0 GA module DUF5565 PF17720.1 VDK86149.1 - 0.043 12.7 0.0 0.057 12.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5565) DUF2569 PF10754.9 VDK86149.1 - 0.45 10.9 8.4 1.9 9.0 7.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2569) DUF5383 PF17355.2 VDK86149.1 - 1.8 9.0 7.6 4 7.8 0.0 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5383) DUF2207 PF09972.9 VDK86149.1 - 4 6.1 8.0 4.7 5.9 3.9 2.0 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 VDK86149.1 - 8.8 6.7 7.5 5.7 7.3 0.2 3.0 2 1 1 3 3 3 0 Orf78 (ac78) Syja_N PF02383.18 VDK86156.1 - 6.8e-74 249.0 0.0 8.9e-74 248.7 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain RNA_pol_3_Rpc31 PF11705.8 VDK86157.1 - 2e-21 77.3 9.9 2.6e-21 76.9 9.9 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 VAD1-2 PF15310.6 VDK86157.1 - 0.045 13.6 4.1 0.068 13.0 4.1 1.2 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling Asparaginase_2 PF01112.18 VDK86157.1 - 0.079 12.0 0.1 2.9 6.8 0.1 2.0 2 0 0 2 2 2 0 Asparaginase U1snRNP70_N PF12220.8 VDK86157.1 - 2.1 9.1 8.2 7.1 7.4 6.0 2.2 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Peptidase_M41 PF01434.18 VDK86158.1 - 1.2e-65 221.0 0.0 2e-65 220.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 VDK86158.1 - 8.4e-45 152.4 0.0 2e-44 151.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK86158.1 - 3.6e-11 42.7 0.1 9.6e-11 41.3 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 VDK86158.1 - 2.2e-10 40.9 0.0 6.9e-10 39.3 0.0 1.9 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 VDK86158.1 - 0.00066 19.7 0.0 0.0039 17.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 VDK86158.1 - 0.00094 19.5 0.0 0.11 12.8 0.0 3.1 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 VDK86158.1 - 0.0025 17.6 0.0 0.01 15.6 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 VDK86158.1 - 0.0056 16.8 0.0 0.019 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 VDK86158.1 - 0.0077 16.6 1.8 0.28 11.6 0.1 3.5 3 1 0 4 4 4 1 AAA ATPase domain IstB_IS21 PF01695.17 VDK86158.1 - 0.01 15.6 0.0 0.036 13.8 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 VDK86158.1 - 0.011 16.3 0.0 0.28 11.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain TIP49 PF06068.13 VDK86158.1 - 0.018 14.3 0.1 0.046 12.9 0.1 1.6 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_17 PF13207.6 VDK86158.1 - 0.064 13.7 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 VDK86158.1 - 0.11 12.8 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 VDK86158.1 - 0.11 11.9 1.0 0.64 9.4 0.2 2.4 3 0 0 3 3 3 0 PhoH-like protein Mg_chelatase PF01078.21 VDK86158.1 - 0.12 11.8 0.1 0.26 10.6 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 VDK86158.1 - 0.14 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 VDK86158.1 - 0.14 12.3 0.0 0.36 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain SCAB-ABD PF16711.5 VDK86158.1 - 1.5 8.8 4.3 1.1 9.2 0.3 2.6 3 0 0 3 3 3 0 Actin-binding domain of plant-specific actin-binding protein Mito_carr PF00153.27 VDK86160.1 - 1.2e-09 38.0 0.1 2.6e-07 30.4 0.0 2.6 2 0 0 2 2 2 2 Mitochondrial carrier protein IFT57 PF10498.9 VDK86163.1 - 6.4e-92 308.3 16.9 1.8e-77 260.8 4.2 2.3 2 1 1 3 3 3 2 Intra-flagellar transport protein 57 DUF1027 PF06265.11 VDK86163.1 - 0.17 11.9 1.1 0.44 10.6 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) ABC_tran_CTD PF16326.5 VDK86163.1 - 0.2 11.9 8.0 4.7 7.5 1.7 3.4 2 1 0 2 2 2 0 ABC transporter C-terminal domain DUF1664 PF07889.12 VDK86163.1 - 0.9 9.6 4.7 3.2 7.8 4.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) CCDC-167 PF15188.6 VDK86163.1 - 3.9 7.9 8.5 13 6.2 3.4 2.8 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 MADF_DNA_bdg PF10545.9 VDK86164.1 - 4.8e-13 49.2 3.0 4.8e-13 49.2 3.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_5 PF13873.6 VDK86164.1 - 5.9e-09 35.9 6.0 1.7e-08 34.4 6.0 1.8 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 VDK86164.1 - 9.1e-05 22.8 5.0 0.00021 21.6 5.0 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Tic110 PF16940.5 VDK86165.1 - 2.1 6.7 7.5 2.3 6.6 7.5 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter Ribosomal_60s PF00428.19 VDK86165.1 - 6.8 7.4 21.2 16 6.1 21.2 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ank_2 PF12796.7 VDK86171.1 - 1.3e-121 397.4 26.5 3.3e-17 62.8 0.0 11.1 4 3 7 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK86171.1 - 6.8e-99 323.1 18.6 2.7e-12 47.0 0.1 13.8 9 3 5 14 14 14 13 Ankyrin repeats (many copies) Ank PF00023.30 VDK86171.1 - 7.4e-93 301.3 45.8 1.3e-05 25.4 0.1 21.9 22 0 0 22 22 22 20 Ankyrin repeat Ank_3 PF13606.6 VDK86171.1 - 2.7e-83 263.8 28.5 9.4e-05 22.5 0.0 21.6 21 0 0 21 21 21 18 Ankyrin repeat Ank_5 PF13857.6 VDK86171.1 - 6.8e-71 233.4 37.1 5.6e-09 36.1 0.0 19.2 5 4 14 20 20 20 18 Ankyrin repeats (many copies) KH_1 PF00013.29 VDK86171.1 - 2.1e-13 49.9 0.8 4.5e-13 48.8 0.8 1.6 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 VDK86171.1 - 0.0034 17.2 0.1 0.014 15.2 0.1 2.1 1 0 0 1 1 1 1 KH domain Vfa1 PF08432.10 VDK86171.1 - 5.5 7.3 17.8 1.6 9.0 12.0 2.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 NARP1 PF12569.8 VDK86171.1 - 7.4 5.3 12.6 14 4.4 12.6 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Globin PF00042.22 VDK86173.1 - 2.3e-18 66.7 0.2 5.4e-18 65.6 0.0 1.7 2 0 0 2 2 2 1 Globin CRT10 PF08728.10 VDK86176.1 - 0.017 13.3 0.1 0.069 11.3 0.0 1.8 1 1 2 3 3 3 0 CRT10 ATG_C PF09333.11 VDK86177.1 - 0.035 14.4 0.0 0.041 14.2 0.0 1.1 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain tRNA_m1G_MT PF01746.21 VDK86178.1 - 3.8e-14 52.9 0.0 1.4e-13 51.0 0.0 2.0 1 1 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Ribosomal_L28 PF00830.19 VDK86178.1 - 0.0013 18.8 0.5 0.0045 17.1 0.0 2.2 2 0 0 2 2 2 1 Ribosomal L28 family DUF4061 PF13270.6 VDK86178.1 - 4.5 7.6 7.1 1 9.7 1.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4061) UQ_con PF00179.26 VDK86179.1 - 5e-18 65.1 0.0 7.3e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Methyltr_RsmB-F PF01189.17 VDK86180.1 - 4.2e-25 88.6 0.1 6.6e-25 87.9 0.1 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F DB PF01682.19 VDK86181.1 - 3.4e-14 52.9 10.0 3.4e-14 52.9 10.0 1.9 2 0 0 2 2 2 1 DB module MAM PF00629.23 VDK86183.1 - 1.6e-10 41.1 0.1 5.2e-07 29.7 0.0 2.9 3 0 0 3 3 3 2 MAM domain, meprin/A5/mu I-set PF07679.16 VDK86185.1 - 9e-39 131.4 0.5 1.1e-12 47.8 0.1 5.4 4 1 0 4 4 4 4 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK86185.1 - 1.2e-34 118.7 0.3 2.2e-10 41.0 0.0 5.5 5 1 0 5 5 5 4 Immunoglobulin domain ig PF00047.25 VDK86185.1 - 7.1e-29 99.8 0.1 9.5e-07 28.9 0.0 5.4 4 2 0 4 4 4 4 Immunoglobulin domain Ig_2 PF13895.6 VDK86185.1 - 1.2e-22 80.0 0.9 3.4e-06 27.3 0.0 5.9 5 2 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 VDK86185.1 - 1.4e-15 57.3 3.5 0.00064 19.9 0.1 5.8 4 3 0 4 4 4 4 Immunoglobulin V-set domain Ig_6 PF18452.1 VDK86185.1 - 7.8e-07 28.6 0.0 1.8 8.2 0.0 4.3 4 0 0 4 4 4 3 Immunoglobulin domain Izumo-Ig PF16706.5 VDK86185.1 - 7.1e-06 26.0 0.0 2 8.5 0.0 4.3 4 0 0 4 4 4 2 Izumo-like Immunoglobulin domain Egh16-like PF11327.8 VDK86185.1 - 0.0044 17.5 0.0 0.015 15.7 0.0 1.8 2 0 0 2 2 2 1 Egh16-like virulence factor Polyhedrin PF00738.18 VDK86185.1 - 0.025 13.9 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Polyhedrin C2-set PF05790.15 VDK86185.1 - 0.036 14.3 0.1 1 9.6 0.0 3.0 4 0 0 4 4 4 0 Immunoglobulin C2-set domain MutL_C PF08676.11 VDK86186.1 - 3.9e-23 81.8 0.0 1.9e-22 79.6 0.0 2.1 2 1 0 2 2 2 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 VDK86186.1 - 1.4e-20 73.2 0.0 4e-20 71.7 0.0 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 VDK86186.1 - 9.5e-13 48.2 0.0 2.6e-12 46.7 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 VDK86186.1 - 7.2e-05 23.3 0.0 0.00025 21.5 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase XPA_C PF05181.12 VDK86187.1 - 2.6e-24 84.9 0.7 4.9e-24 84.0 0.7 1.5 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 VDK86187.1 - 8.6e-11 41.7 7.2 2.3e-10 40.3 7.2 1.8 1 0 0 1 1 1 1 XPA protein N-terminal DUF4503 PF14951.6 VDK86187.1 - 0.097 11.1 0.1 0.15 10.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) PP2C_C PF07830.13 VDK86187.1 - 0.2 12.2 0.6 5.5 7.5 0.6 2.6 2 1 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain zf-C4pol PF14260.6 VDK86187.1 - 2.4 8.7 8.6 1.5 9.4 2.6 3.0 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta Jagunal PF07086.12 VDK86188.1 - 1.8e-69 233.5 2.9 2.2e-69 233.3 2.9 1.0 1 0 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis Serpin PF00079.20 VDK86189.1 - 7.9e-50 170.2 2.0 2.9e-49 168.3 2.0 1.7 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) IRK_C PF17655.1 VDK86191.1 - 1.9e-71 239.2 0.0 3e-71 238.6 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 VDK86191.1 - 5.1e-48 162.5 4.8 7.7e-48 161.9 4.8 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 VDK86191.1 - 0.00029 20.7 2.5 0.00029 20.7 2.5 2.3 2 0 0 2 2 2 1 Ion channel 7tm_1 PF00001.21 VDK86192.1 - 0.0046 16.3 0.8 0.01 15.2 0.8 1.6 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4281 PF14108.6 VDK86192.1 - 0.16 12.4 2.0 0.32 11.3 1.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4281) TMEM43 PF07787.12 VDK86192.1 - 0.39 10.1 3.2 15 4.9 1.0 2.8 2 1 0 2 2 2 0 Transmembrane protein 43 FlaC_arch PF05377.11 VDK86194.1 - 0.015 15.6 0.5 0.024 15.0 0.5 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Ion_trans PF00520.31 VDK86197.1 - 6e-10 38.8 0.0 7.2e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 VDK86197.1 - 0.00082 18.2 0.1 0.0013 17.5 0.1 1.2 1 0 0 1 1 1 1 Polycystin cation channel DUF2628 PF10947.8 VDK86197.1 - 0.47 10.8 2.1 1.4 9.3 2.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2628) Ion_trans PF00520.31 VDK86198.1 - 3.5e-06 26.4 0.2 5.7e-06 25.7 0.2 1.3 1 0 0 1 1 1 1 Ion transport protein Gpr1_Fun34_YaaH PF01184.19 VDK86198.1 - 0.055 13.1 0.1 0.08 12.5 0.1 1.1 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family RRT14 PF17075.5 VDK86198.1 - 0.26 11.4 4.0 0.75 9.9 4.0 1.8 1 1 0 1 1 1 0 Regular of rDNA transcription protein 14 zf-AN1 PF01428.16 VDK86200.1 - 7.5e-24 83.6 30.6 2.5e-13 49.9 10.1 2.8 3 0 0 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 VDK86200.1 - 0.00046 20.5 20.4 0.088 13.2 6.7 2.5 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain IBR PF01485.21 VDK86200.1 - 7.8 6.8 27.6 7.6 6.9 13.8 3.8 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Phage_GP20 PF06810.11 VDK86201.1 - 0.017 15.0 0.1 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 CENP-F_leu_zip PF10473.9 VDK86201.1 - 0.04 13.9 0.4 0.04 13.9 0.4 1.7 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 XhlA PF10779.9 VDK86201.1 - 0.38 11.0 4.1 0.77 10.0 0.7 2.1 2 0 0 2 2 2 0 Haemolysin XhlA LRR_4 PF12799.7 VDK86202.1 - 5.3e-13 48.9 14.4 0.15 12.5 0.6 7.3 2 2 5 8 8 8 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 VDK86202.1 - 2.8e-09 36.3 23.2 0.0057 16.6 0.4 9.3 11 0 0 11 11 11 4 Leucine Rich repeat LRR_1 PF00560.33 VDK86202.1 - 8.3e-05 22.6 26.8 0.98 10.2 0.1 10.5 8 3 2 10 10 10 2 Leucine Rich Repeat LRR_8 PF13855.6 VDK86202.1 - 0.016 14.9 6.2 15 5.5 0.3 5.3 5 1 1 6 6 6 0 Leucine rich repeat Pkinase PF00069.25 VDK86206.1 - 0.00019 20.9 0.0 0.00028 20.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 VDK86206.1 - 0.062 12.1 0.0 0.088 11.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Collagen PF01391.18 VDK86208.1 - 1.5e-25 88.7 78.8 1.8e-10 40.4 24.1 3.2 3 0 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK86208.1 - 4.5e-15 55.4 0.7 6.7e-15 54.9 0.7 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain PI3_PI4_kinase PF00454.27 VDK86222.1 - 4.3e-37 128.3 0.0 6.5e-37 127.7 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase VWA PF00092.28 VDK86223.1 - 3.6e-57 193.4 4.1 2.7e-28 99.4 0.3 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 VDK86223.1 - 6.8e-32 110.3 0.5 1e-15 58.3 0.0 2.8 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_3 PF13768.6 VDK86223.1 - 9.2e-06 25.7 0.0 0.038 13.9 0.0 2.5 2 1 0 2 2 2 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 VDK86223.1 - 0.00071 19.0 0.1 0.021 14.2 0.0 2.7 3 0 0 3 3 3 1 VWA domain containing CoxE-like protein JHD PF17811.1 VDK86225.1 - 5e-06 27.0 0.1 5e-06 27.0 0.1 2.8 3 0 0 3 3 3 1 Jumonji helical domain JmjC PF02373.22 VDK86225.1 - 3.6e-05 24.1 4.4 0.00022 21.6 0.5 3.7 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 VDK86225.1 - 3.9e-05 23.5 6.6 6.2e-05 22.8 0.0 3.8 3 2 0 3 3 3 1 Cupin-like domain DUF4157 PF13699.6 VDK86225.1 - 0.056 13.7 0.1 0.28 11.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4157) DUF4897 PF16238.5 VDK86225.1 - 6.3 6.6 10.4 16 5.3 0.9 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4897) DpaA_N PF16924.5 VDK86226.1 - 0.1 12.7 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain HTH_psq PF05225.16 VDK86227.1 - 5.8e-26 90.0 0.2 1.2e-13 50.6 0.0 2.7 3 0 0 3 3 3 2 helix-turn-helix, Psq domain Haspin_kinase PF12330.8 VDK86228.1 - 5.8e-35 120.9 0.2 7.6e-35 120.5 0.2 1.0 1 0 0 1 1 1 1 Haspin like kinase domain Ank_2 PF12796.7 VDK86234.1 - 3.8e-73 242.1 9.9 1.6e-11 44.6 0.0 7.7 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK86234.1 - 2.8e-50 168.0 20.5 8.7e-10 39.0 0.2 10.6 6 3 4 11 11 11 10 Ankyrin repeats (many copies) Ank PF00023.30 VDK86234.1 - 2.3e-47 157.4 18.5 0.00074 19.9 0.0 13.6 14 0 0 14 14 14 10 Ankyrin repeat Ank_3 PF13606.6 VDK86234.1 - 1e-46 151.5 21.0 0.0005 20.3 0.0 15.0 15 0 0 15 15 15 10 Ankyrin repeat Ank_5 PF13857.6 VDK86234.1 - 1e-44 150.0 18.9 3e-07 30.6 0.3 12.2 3 3 11 14 14 14 12 Ankyrin repeats (many copies) Dopey_N PF04118.14 VDK86235.1 - 1.1e-94 317.0 0.0 1.1e-94 317.0 0.0 3.0 4 0 0 4 4 4 1 Dopey, N-terminal WD40_4 PF16300.5 VDK86237.1 - 6.5e-16 57.9 0.1 1.1e-15 57.3 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 VDK86237.1 - 3.8e-07 30.7 3.0 0.00017 22.3 0.1 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF1899 PF08953.11 VDK86237.1 - 5.4e-06 26.2 0.2 1.8e-05 24.5 0.2 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1899) eIF2A PF08662.11 VDK86237.1 - 0.00026 20.9 0.3 0.0011 18.8 0.2 2.1 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 VDK86237.1 - 0.00036 20.2 0.0 0.047 13.3 0.0 2.4 1 1 1 2 2 2 1 PQQ-like domain ANAPC4_WD40 PF12894.7 VDK86237.1 - 0.0018 18.5 1.1 0.077 13.3 0.2 3.1 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK86237.1 - 0.018 14.0 0.0 0.047 12.7 0.0 1.7 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SlyX PF04102.12 VDK86237.1 - 5.8 7.6 7.0 0.41 11.3 1.1 2.1 2 0 0 2 2 2 0 SlyX SRPRB PF09439.10 VDK86246.1 - 1.8e-49 167.7 0.1 2.4e-49 167.2 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 VDK86246.1 - 1.2e-14 54.2 0.0 1.5e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK86246.1 - 1e-09 38.5 0.1 2e-09 37.5 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK86246.1 - 7.1e-08 32.1 0.0 9.7e-08 31.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 VDK86246.1 - 3.6e-06 27.2 0.0 7.7e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK86246.1 - 0.00033 20.3 0.1 0.00069 19.2 0.0 1.6 2 0 0 2 2 2 1 Ras family FeoB_N PF02421.18 VDK86246.1 - 0.0019 17.7 0.0 0.0032 17.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 VDK86246.1 - 0.0031 17.4 0.0 0.011 15.5 0.0 1.8 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein TRAP_beta PF05753.14 VDK86246.1 - 0.0095 15.3 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) GTP_EFTU PF00009.27 VDK86246.1 - 0.011 15.3 0.0 0.87 9.1 0.0 2.2 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 VDK86246.1 - 0.02 14.4 0.1 0.033 13.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 VDK86246.1 - 0.021 14.9 0.1 0.052 13.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 VDK86246.1 - 0.038 14.2 0.0 0.062 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 VDK86246.1 - 0.039 13.0 0.0 0.067 12.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF5522 PF17653.1 VDK86247.1 - 1.3e-22 79.4 2.9 2.5e-22 78.6 2.9 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5522) Oxidored-like PF09791.9 VDK86247.1 - 0.019 14.6 0.8 0.019 14.6 0.8 2.0 2 1 0 2 2 2 0 Oxidoreductase-like protein, N-terminal TerB_N PF13208.6 VDK86247.1 - 0.08 12.6 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 TerB N-terminal domain Ribosomal_L14 PF00238.19 VDK86248.1 - 2.1e-08 34.3 0.0 4e-08 33.4 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein L14p/L23e BORCS6 PF10157.9 VDK86249.1 - 5e-35 121.0 2.1 6.4e-35 120.6 2.1 1.1 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 DUF948 PF06103.11 VDK86249.1 - 0.0073 16.5 0.9 0.032 14.5 0.9 2.0 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) ApoLp-III PF07464.11 VDK86249.1 - 0.044 13.9 0.8 0.48 10.5 0.0 2.4 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 VDK86249.1 - 0.055 13.5 2.6 4.2 7.4 0.2 2.5 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PHR PF08005.12 VDK86250.1 - 1.1e-37 130.1 0.0 2.1e-37 129.1 0.0 1.5 1 0 0 1 1 1 1 PHR domain RCC1 PF00415.18 VDK86250.1 - 1e-20 74.1 16.3 2e-10 41.1 1.0 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 VDK86250.1 - 3.3e-18 65.0 21.9 9.1e-07 28.5 2.9 5.9 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Abhydrolase_1 PF00561.20 VDK86256.1 - 3.2e-10 40.1 0.1 1.6e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDK86256.1 - 1.1e-05 24.9 0.0 1.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 VDK86256.1 - 0.00079 20.1 0.0 0.0017 19.0 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family KH_1 PF00013.29 VDK86257.1 - 4.1e-32 109.8 9.7 7.1e-18 64.2 0.6 2.8 3 0 0 3 3 3 2 KH domain KH_2 PF07650.17 VDK86257.1 - 1.6e-08 34.3 2.5 0.00024 20.9 0.0 2.4 2 0 0 2 2 2 2 KH domain TFIIA PF03153.13 VDK86257.1 - 2.8e-06 27.6 13.0 3.2e-06 27.4 13.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RskA PF10099.9 VDK86257.1 - 1.4e-05 25.5 4.1 2.5e-05 24.7 4.1 1.5 1 0 0 1 1 1 1 Anti-sigma-K factor rskA DUF2722 PF10846.8 VDK86257.1 - 3.3e-05 23.0 14.6 4.4e-05 22.6 14.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) SprA-related PF12118.8 VDK86257.1 - 0.00021 20.6 7.9 0.00031 20.0 7.9 1.4 1 0 0 1 1 1 1 SprA-related family Suf PF05843.14 VDK86257.1 - 0.00057 20.0 6.2 0.00076 19.6 6.2 1.3 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) DUF2052 PF09747.9 VDK86257.1 - 0.0012 19.0 0.8 0.0016 18.7 0.8 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Med15 PF09606.10 VDK86257.1 - 0.0015 17.4 23.3 0.002 16.9 23.3 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal KH_4 PF13083.6 VDK86257.1 - 0.0029 17.4 0.8 1 9.3 0.3 2.6 2 0 0 2 2 2 1 KH domain DDHD PF02862.17 VDK86257.1 - 0.0039 17.4 0.2 0.004 17.3 0.2 1.2 1 0 0 1 1 1 1 DDHD domain DUF4820 PF16091.5 VDK86257.1 - 0.0041 16.5 1.0 0.0067 15.8 1.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) KH_5 PF13184.6 VDK86257.1 - 0.0046 17.0 4.6 0.75 9.9 1.1 2.6 2 0 0 2 2 2 2 NusA-like KH domain MecA PF05389.12 VDK86257.1 - 0.0087 15.7 0.1 0.011 15.4 0.1 1.2 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) FHIPEP PF00771.20 VDK86257.1 - 0.0097 14.4 2.5 0.014 13.9 2.5 1.1 1 0 0 1 1 1 1 FHIPEP family Presenilin PF01080.17 VDK86257.1 - 0.015 14.1 2.5 0.018 13.8 2.5 1.2 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 VDK86257.1 - 0.032 13.7 3.3 0.045 13.2 3.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Trp_oprn_chp PF09534.10 VDK86257.1 - 0.068 13.0 2.1 0.43 10.4 0.2 2.2 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CPSF100_C PF13299.6 VDK86257.1 - 0.13 12.5 2.6 0.2 11.8 2.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.6 VDK86257.1 - 0.14 10.1 18.2 0.18 9.6 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EIIBC-GUT_N PF03612.14 VDK86257.1 - 0.2 11.4 5.8 0.43 10.3 5.8 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PAT1 PF09770.9 VDK86257.1 - 0.23 9.7 15.8 0.3 9.3 15.8 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Methyltransf_12 PF08242.12 VDK86257.1 - 0.27 12.0 0.6 0.55 11.0 0.6 1.5 1 0 0 1 1 1 0 Methyltransferase domain Baculo_PP31 PF05311.11 VDK86257.1 - 0.42 10.1 4.5 0.62 9.5 4.5 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) PepSY_TM PF03929.16 VDK86257.1 - 0.43 10.2 2.0 0.55 9.8 2.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region Pex14_N PF04695.13 VDK86257.1 - 0.46 11.1 18.3 0.11 13.1 15.1 1.6 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region UPF0560 PF10577.9 VDK86257.1 - 0.49 8.8 11.5 0.64 8.5 11.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Orf78 PF06024.12 VDK86257.1 - 0.54 10.6 2.7 1 9.7 2.7 1.4 1 0 0 1 1 1 0 Orf78 (ac78) eIF-3_zeta PF05091.12 VDK86257.1 - 0.55 9.1 9.6 0.82 8.6 9.6 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Rxt3 PF08642.10 VDK86257.1 - 0.6 10.9 3.2 1.1 10.0 3.2 1.4 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 EphA2_TM PF14575.6 VDK86257.1 - 0.68 10.8 3.9 0.89 10.5 2.5 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Glt_symporter PF03616.14 VDK86257.1 - 1.2 7.7 2.7 1.8 7.2 2.7 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Spt20 PF12090.8 VDK86257.1 - 1.7 8.2 35.5 3.4 7.2 35.5 1.4 1 0 0 1 1 1 0 Spt20 family DUF4407 PF14362.6 VDK86257.1 - 2.3 7.5 9.7 3.7 6.8 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4834 PF16118.5 VDK86257.1 - 3.3 8.7 11.8 7.5 7.6 11.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF3464 PF11947.8 VDK86257.1 - 3.6 7.3 8.2 6.4 6.5 8.2 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF2367 PF10164.9 VDK86257.1 - 5.7 7.5 8.4 2.2 8.8 5.0 2.1 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2367) TERB2 PF15101.6 VDK86257.1 - 6.9 6.7 14.6 12 5.8 14.6 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Roughex PF06020.11 VDK86257.1 - 8.5 5.4 11.7 13 4.8 11.7 1.3 1 0 0 1 1 1 0 Drosophila roughex protein SAC3_GANP PF03399.16 VDK86258.1 - 1.9e-23 83.3 5.8 1.4e-21 77.1 5.8 2.0 1 1 0 1 1 1 1 SAC3/GANP family CLU_N PF15044.6 VDK86258.1 - 0.1 13.0 0.3 0.31 11.4 0.1 1.9 2 0 0 2 2 2 0 Mitochondrial function, CLU-N-term ARA70 PF12489.8 VDK86258.1 - 0.1 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Nuclear coactivator Pkinase PF00069.25 VDK86260.1 - 5.5e-31 107.9 0.0 1.4e-30 106.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86260.1 - 1.9e-21 76.5 0.2 4.1e-21 75.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DUF3439 PF11921.8 VDK86261.1 - 0.039 13.9 4.4 0.078 13.0 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF3135 PF11333.8 VDK86261.1 - 0.078 13.2 0.0 0.19 12.0 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3135) Pinin_SDK_memA PF04696.13 VDK86264.1 - 5.3e-26 91.2 20.4 5.3e-26 91.2 20.4 2.1 1 1 1 2 2 2 1 pinin/SDK/memA/ protein conserved region Pinin_SDK_N PF04697.13 VDK86264.1 - 7.7e-07 29.8 1.5 7.7e-07 29.8 1.5 3.0 3 1 0 3 3 3 1 pinin/SDK conserved region Ion_trans PF00520.31 VDK86265.1 - 8.9e-44 149.6 11.9 1.5e-43 148.8 11.9 1.4 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 VDK86265.1 - 1.3e-28 99.1 0.0 2.9e-28 98.1 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 VDK86265.1 - 6.7e-13 48.4 5.2 6.7e-13 48.4 5.2 2.3 2 0 0 2 2 2 1 Ion channel AmpE PF17113.5 VDK86265.1 - 0.031 13.6 0.7 0.055 12.8 0.7 1.3 1 0 0 1 1 1 0 Regulatory signalling modulator protein AmpE tRNA-synt_1b PF00579.25 VDK86271.1 - 3.8e-93 312.0 0.0 1.5e-62 211.6 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) Toprim_N PF08275.11 VDK86271.1 - 0.17 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 DNA primase catalytic core, N-terminal domain HtrL_YibB PF09612.10 VDK86272.1 - 7.9e-61 205.9 0.6 2e-60 204.6 0.6 1.6 1 0 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) DUF3439 PF11921.8 VDK86272.1 - 0.0013 18.7 4.2 0.0013 18.7 4.2 3.0 2 1 2 4 4 4 1 Domain of unknown function (DUF3439) Sarcoglycan_1 PF04790.13 VDK86278.1 - 1e-15 57.8 0.2 1.3e-15 57.5 0.2 1.1 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein DUF4133 PF13571.6 VDK86278.1 - 0.037 14.3 0.4 0.069 13.5 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4133) DUF3081 PF11280.8 VDK86278.1 - 0.07 13.0 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3081) zf-Di19 PF05605.12 VDK86280.1 - 1.9e-05 24.9 6.7 1.9e-05 24.9 6.7 3.0 2 1 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-CCCH_2 PF14608.6 VDK86280.1 - 0.00012 22.4 19.1 0.00063 20.1 9.5 3.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-C2H2_4 PF13894.6 VDK86280.1 - 0.00058 20.5 11.3 0.0046 17.7 4.3 5.1 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2_9 PF16293.5 VDK86280.1 - 0.012 15.4 4.0 0.35 10.7 0.7 3.2 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Zn-ribbon_8 PF09723.10 VDK86280.1 - 0.013 15.6 11.3 0.013 15.6 11.3 3.7 3 1 0 3 3 3 0 Zinc ribbon domain zf-C2H2 PF00096.26 VDK86280.1 - 0.079 13.4 0.8 0.079 13.4 0.8 4.2 5 0 0 5 5 5 0 Zinc finger, C2H2 type Evr1_Alr PF04777.13 VDK86280.1 - 8.5 6.9 8.7 27 5.3 0.3 2.6 1 1 1 2 2 2 0 Erv1 / Alr family LAP1C PF05609.12 VDK86281.1 - 0.7 8.9 15.7 0.82 8.7 15.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 VDK86281.1 - 2.3 5.2 18.1 2.6 5.0 18.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4551 PF15087.6 VDK86281.1 - 2.7 6.7 21.4 3.1 6.5 21.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Hid1 PF12722.7 VDK86281.1 - 5.7 4.9 15.9 6.1 4.8 15.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Cullin PF00888.22 VDK86282.1 - 1.6e-181 605.1 14.8 2.2e-181 604.7 14.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 VDK86282.1 - 7.4e-29 99.6 4.8 2.7e-28 97.8 4.8 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain Phage_TAC_12 PF12363.8 VDK86282.1 - 0.017 15.5 0.1 0.095 13.1 0.1 2.4 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC MarR PF01047.22 VDK86282.1 - 0.13 12.3 3.6 0.65 10.0 0.1 3.2 3 0 0 3 3 3 0 MarR family Mating_N PF12731.7 VDK86282.1 - 2 8.6 4.6 1 9.5 0.1 2.9 3 1 0 3 3 3 0 Mating-type protein beta 1 Glyco_transf_25 PF01755.17 VDK86283.1 - 1e-26 94.0 0.0 1.7e-25 90.1 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Anp1 PF03452.14 VDK86283.1 - 0.00089 18.8 0.0 0.21 10.9 0.1 2.3 1 1 1 2 2 2 2 Anp1 Gal_mutarotas_2 PF13802.6 VDK86283.1 - 0.048 14.0 1.5 0.57 10.6 0.3 2.6 2 0 0 2 2 2 0 Galactose mutarotase-like Pkinase PF00069.25 VDK86284.1 - 7.6e-39 133.6 0.0 9.6e-39 133.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86284.1 - 1.8e-19 70.1 0.0 2.1e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK86284.1 - 1.9e-05 24.7 0.0 5.2e-05 23.3 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 VDK86284.1 - 0.0074 15.6 0.0 1 8.6 0.0 2.6 2 1 0 2 2 2 2 Kinase-like Pox_ser-thr_kin PF05445.11 VDK86284.1 - 0.15 11.0 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase zf-CCHC_5 PF14787.6 VDK86284.1 - 0.57 9.9 2.2 1.1 9.0 2.2 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger P21-Arc PF04062.14 VDK86285.1 - 4.3e-76 254.8 0.0 4.8e-76 254.6 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit ACBP PF00887.19 VDK86286.1 - 5.5e-10 39.3 0.7 5.5e-10 39.3 0.7 1.7 2 0 0 2 2 2 1 Acyl CoA binding protein TENA_THI-4 PF03070.16 VDK86286.1 - 0.16 11.7 1.7 6.2 6.6 0.2 2.1 1 1 1 2 2 2 0 TENA/THI-4/PQQC family Peptidase_M8 PF01457.16 VDK86287.1 - 7.3e-42 143.7 6.1 7.4e-39 133.8 3.1 3.9 2 1 1 3 3 3 2 Leishmanolysin Condensin2nSMC PF12422.8 VDK86289.1 - 0.046 13.9 0.4 0.088 13.0 0.4 1.4 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit Folliculin PF11704.8 VDK86289.1 - 0.055 13.4 0.1 0.14 12.0 0.1 1.6 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Phospholip_B PF04916.13 VDK86290.1 - 2e-61 208.2 3.8 2.2e-61 208.0 3.8 1.0 1 0 0 1 1 1 1 Phospholipase B DUF737 PF05300.11 VDK86295.1 - 0.16 12.3 8.3 0.23 11.8 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) DUF3385 PF11865.8 VDK86297.1 - 0.021 14.7 0.2 0.097 12.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) HEAT PF02985.22 VDK86297.1 - 0.065 13.5 0.0 0.065 13.5 0.0 6.5 8 0 0 8 8 8 0 HEAT repeat AEP1 PF17049.5 VDK86297.1 - 0.069 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 ATPase expression protein 1 HEAT PF02985.22 VDK86299.1 - 1.1e-09 37.7 14.7 0.41 11.0 0.1 7.4 7 0 0 7 7 7 4 HEAT repeat HEAT_EZ PF13513.6 VDK86299.1 - 1.4e-06 28.7 9.2 0.24 12.0 0.2 5.9 4 1 2 6 6 6 4 HEAT-like repeat Cnd1 PF12717.7 VDK86299.1 - 2.1e-05 24.6 9.1 0.032 14.3 2.0 4.4 2 1 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 VDK86299.1 - 0.091 12.5 1.0 2.8 7.7 0.1 3.0 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis TAF6_C PF07571.13 VDK86299.1 - 0.13 12.6 2.3 8.8 6.7 0.0 3.5 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain IFRD PF05004.13 VDK86299.1 - 0.13 11.3 1.7 3.9 6.5 0.0 2.9 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 VDK86299.1 - 0.47 10.0 5.1 10 5.6 0.6 3.7 3 1 0 3 3 3 0 CLASP N terminal RTP1_C1 PF10363.9 VDK86299.1 - 1.1 9.4 4.5 28 4.9 0.1 4.1 2 1 2 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 LMF1 PF06762.14 VDK86308.1 - 6.7e-132 440.7 19.1 9.2e-132 440.3 19.1 1.2 1 0 0 1 1 1 1 Lipase maturation factor DUF4579 PF15158.6 VDK86308.1 - 0.15 11.8 2.9 0.44 10.3 2.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4579) DUF19 PF01579.18 VDK86309.1 - 0.0011 18.7 2.8 0.066 13.0 2.8 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF19) Thioredoxin PF00085.20 VDK86310.1 - 2.9e-08 33.6 0.0 0.0016 18.4 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Abhydrolase_3 PF07859.13 VDK86320.1 - 2.8e-45 154.8 0.0 8.6e-35 120.5 0.0 2.0 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 VDK86320.1 - 1.7e-06 27.2 0.1 2.3e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 VDK86320.1 - 0.0016 17.4 0.0 0.5 9.2 0.0 2.2 2 0 0 2 2 2 2 Carboxylesterase family Peptidase_S9 PF00326.21 VDK86320.1 - 0.0042 16.6 0.0 0.22 11.0 0.0 2.8 3 0 0 3 3 3 1 Prolyl oligopeptidase family zf-H2C2_2 PF13465.6 VDK86322.1 - 7.9e-20 70.3 37.5 2.8e-07 30.7 1.7 6.3 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2 PF00096.26 VDK86322.1 - 1.4e-19 69.3 41.0 2.6e-05 24.4 1.7 5.7 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK86322.1 - 1e-14 54.0 37.5 0.00065 20.3 1.5 5.8 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK86322.1 - 8.3e-12 45.1 19.8 0.018 15.3 0.1 5.8 5 0 0 5 5 5 5 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDK86322.1 - 4.1e-08 33.0 30.3 0.042 13.8 2.0 5.9 6 0 0 6 6 5 4 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 VDK86322.1 - 0.002 18.8 18.2 0.03 15.0 2.8 3.9 1 1 2 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf-met PF12874.7 VDK86322.1 - 0.0029 18.0 30.5 0.21 12.0 0.1 6.0 6 1 0 6 6 6 2 Zinc-finger of C2H2 type zf_UBZ PF18439.1 VDK86322.1 - 0.0038 16.8 14.8 4.9 6.8 0.3 5.3 5 0 0 5 5 5 2 Ubiquitin-Binding Zinc Finger XPA_N PF01286.18 VDK86322.1 - 0.0078 16.2 13.4 2.8 8.1 0.2 5.3 5 0 0 5 5 5 1 XPA protein N-terminal Prok-RING_1 PF14446.6 VDK86322.1 - 0.018 14.9 13.5 15 5.6 0.1 5.2 5 0 0 5 5 5 0 Prokaryotic RING finger family 1 zf-BED PF02892.15 VDK86322.1 - 0.023 14.7 24.5 0.35 10.9 5.8 4.7 2 1 3 5 5 5 0 BED zinc finger zf-LYAR PF08790.11 VDK86322.1 - 0.063 13.2 29.0 0.089 12.7 0.4 6.0 5 1 0 5 5 5 0 LYAR-type C2HC zinc finger Ta0938 PF11494.8 VDK86322.1 - 0.07 13.4 1.6 0.42 10.9 0.0 2.7 1 1 2 3 3 3 0 Ta0938 zinc_ribbon_15 PF17032.5 VDK86322.1 - 0.11 13.3 14.2 4.8 8.0 0.8 3.2 1 1 2 3 3 3 0 zinc-ribbon family zf-AN1 PF01428.16 VDK86322.1 - 0.35 11.1 24.3 3.7 7.8 0.2 5.4 6 0 0 6 6 5 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 VDK86322.1 - 0.38 10.9 19.2 4.9 7.4 0.2 4.4 1 1 3 5 5 5 0 Zinc ribbon domain DZR PF12773.7 VDK86322.1 - 0.53 10.4 20.2 34 4.6 14.6 3.3 1 1 2 3 3 3 0 Double zinc ribbon HypA PF01155.19 VDK86322.1 - 0.54 10.3 12.7 22 5.1 0.9 3.0 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA HNH_5 PF14279.6 VDK86322.1 - 0.75 9.7 13.5 21 5.1 0.3 5.0 4 1 0 4 4 4 0 HNH endonuclease DUF2256 PF10013.9 VDK86322.1 - 1.3 9.2 15.6 23 5.2 0.1 5.1 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) FYVE PF01363.21 VDK86322.1 - 3.2 8.0 23.7 6.2 7.0 6.7 4.0 1 1 2 3 3 3 0 FYVE zinc finger zf-CHCC PF10276.9 VDK86322.1 - 3.2 7.9 16.3 1.1 9.3 0.3 4.4 5 0 0 5 5 4 0 Zinc-finger domain zf_C2H2_ZHX PF18387.1 VDK86322.1 - 4.3 7.1 15.9 1.8 8.3 0.2 4.1 3 1 1 4 4 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-Di19 PF05605.12 VDK86322.1 - 4.7 7.6 26.1 0.1 12.9 4.8 4.1 1 1 2 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding zf-MYND PF01753.18 VDK86322.1 - 4.8 7.4 15.7 0.45 10.6 4.0 4.0 2 2 1 3 3 3 0 MYND finger Cys_rich_CPXG PF14255.6 VDK86322.1 - 7.1 6.6 8.3 14 5.7 1.0 3.5 3 1 0 3 3 3 0 Cysteine-rich CPXCG MIG-14_Wnt-bd PF06664.12 VDK86325.1 - 8.2e-79 264.9 18.0 8.2e-79 264.9 18.0 2.0 2 0 0 2 2 2 2 Wnt-binding factor required for Wnt secretion Peptidase_C48 PF02902.19 VDK86326.1 - 1.9e-09 37.7 0.1 5.8e-09 36.1 0.0 1.6 1 1 1 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C48 PF02902.19 VDK86327.1 - 0.028 14.3 0.0 0.036 13.9 0.0 1.1 1 0 0 1 1 1 0 Ulp1 protease family, C-terminal catalytic domain STD1 PF17235.2 VDK86327.1 - 0.15 11.7 0.1 0.21 11.2 0.1 1.4 1 1 0 1 1 1 0 STD1/MTH1 His_Phos_2 PF00328.22 VDK86328.1 - 6.4e-30 104.8 0.0 4.9e-27 95.3 0.0 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) RIC1 PF07064.13 VDK86329.1 - 3.4e-31 108.6 0.0 6.7e-31 107.6 0.0 1.5 1 0 0 1 1 1 1 RIC1 PDZ_6 PF17820.1 VDK86334.1 - 3.5e-10 39.6 1.0 5.1e-10 39.0 0.2 1.8 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 VDK86334.1 - 1.1e-09 38.6 0.0 2.2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain LIM PF00412.22 VDK86334.1 - 1.4e-08 34.8 4.9 2.8e-08 33.9 4.9 1.5 1 0 0 1 1 1 1 LIM domain PDZ_2 PF13180.6 VDK86334.1 - 1.3e-05 25.4 0.1 6e-05 23.3 0.1 2.1 1 0 0 1 1 1 1 PDZ domain DUF4757 PF15949.5 VDK86335.1 - 1.1e-06 29.2 0.4 1.5e-06 28.8 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4757) PAP2 PF01569.21 VDK86341.1 - 1.6e-06 27.9 0.1 2.1e-06 27.6 0.1 1.1 1 0 0 1 1 1 1 PAP2 superfamily Spond_N PF06468.13 VDK86342.1 - 1e-54 185.6 0.9 7.1e-53 179.6 0.9 2.2 1 1 0 1 1 1 1 Spondin_N TSP_1 PF00090.19 VDK86342.1 - 1.2e-46 156.7 53.1 2.8e-11 43.4 3.1 7.1 6 0 0 6 6 6 5 Thrombospondin type 1 domain Kunitz_BPTI PF00014.23 VDK86342.1 - 5.4e-18 65.0 11.2 5.4e-18 65.0 11.2 2.7 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Reeler PF02014.16 VDK86342.1 - 5.7e-18 65.9 0.0 1.3e-17 64.8 0.0 1.6 1 0 0 1 1 1 1 Reeler domain CSD PF00313.22 VDK86343.1 - 2.7e-21 75.2 0.1 6.3e-21 74.0 0.1 1.7 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain An_peroxidase PF03098.15 VDK86345.1 - 1.9e-151 505.3 0.0 2.1e-151 505.1 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Glycogen_syn PF05693.13 VDK86349.1 - 3.8e-171 570.9 10.0 7.8e-87 292.3 0.1 3.2 1 1 2 3 3 3 3 Glycogen synthase Glycos_transf_1 PF00534.20 VDK86349.1 - 4.4e-05 23.1 0.0 0.0001 21.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 VDK86349.1 - 0.00022 21.7 0.0 0.00074 20.0 0.0 1.9 1 1 1 2 2 2 1 Glycosyl transferases group 1 Acatn PF13000.7 VDK86351.1 - 3.2e-113 379.1 18.5 1.5e-81 274.6 8.1 3.0 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 Claudin_2 PF13903.6 VDK86354.1 - 2.1e-05 24.4 7.4 5.1e-05 23.1 7.4 1.6 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction SLATT_3 PF18184.1 VDK86354.1 - 0.019 15.1 0.2 0.019 15.1 0.2 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 Trp_oprn_chp PF09534.10 VDK86354.1 - 0.14 12.0 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Polysacc_synt_C PF14667.6 VDK86354.1 - 0.94 9.5 10.8 0.23 11.5 6.2 2.1 2 1 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Arteri_Gl PF00951.18 VDK86354.1 - 0.99 9.2 8.8 0.32 10.8 6.0 1.6 1 1 0 1 1 1 0 Arterivirus GL envelope glycoprotein Cbl_N PF02262.16 VDK86355.1 - 8.8e-48 161.4 1.1 1.3e-47 160.9 1.1 1.3 1 0 0 1 1 1 1 CBL proto-oncogene N-terminal domain 1 Cbl_N3 PF02762.14 VDK86355.1 - 1.4e-45 153.0 0.0 2.7e-45 152.1 0.0 1.5 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, SH2-like domain Cbl_N2 PF02761.14 VDK86355.1 - 7.7e-36 122.7 3.1 1.6e-35 121.7 3.1 1.6 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain Prok-RING_4 PF14447.6 VDK86355.1 - 3.3e-13 49.3 8.7 6e-13 48.4 8.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 VDK86355.1 - 2.3e-11 43.4 7.3 3.6e-11 42.7 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK86355.1 - 7.7e-09 35.3 7.0 1.4e-08 34.5 7.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK86355.1 - 2.8e-07 30.7 7.1 5.1e-07 29.9 7.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK86355.1 - 1e-06 28.7 5.3 2.1e-06 27.6 5.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDK86355.1 - 1.4e-05 24.9 7.6 2.9e-05 23.8 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK86355.1 - 0.0037 17.2 10.1 0.0084 16.1 10.1 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 VDK86355.1 - 0.026 14.8 6.7 0.051 13.9 6.7 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 VDK86355.1 - 0.04 14.1 7.8 0.078 13.2 7.8 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 VDK86355.1 - 0.24 11.6 4.9 0.6 10.3 4.9 1.6 1 1 0 1 1 1 0 Zinc-binding RING-finger Zn_ribbon_17 PF17120.5 VDK86355.1 - 1.1 9.0 6.5 1.9 8.2 6.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PI3_PI4_kinase PF00454.27 VDK86356.1 - 5.7e-44 150.8 0.8 6e-43 147.5 0.8 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 VDK86356.1 - 7e-30 103.8 2.6 1.5e-29 102.7 2.6 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PX PF00787.24 VDK86356.1 - 4e-13 49.3 0.2 1.2e-12 47.8 0.2 1.9 1 0 0 1 1 1 1 PX domain C2 PF00168.30 VDK86356.1 - 8.7e-12 45.2 0.0 1.9e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain PI3K_C2 PF00792.24 VDK86356.1 - 1.7e-05 24.8 0.0 5.3e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 VDK86356.1 - 0.00094 19.3 0.1 0.0025 18.0 0.1 1.7 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 VDK86356.1 - 0.0023 17.3 0.0 0.0051 16.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) Pkinase PF00069.25 VDK86358.1 - 3.1e-57 193.9 0.3 3.7e-57 193.7 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86358.1 - 4.3e-30 104.9 0.1 5.4e-30 104.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK86358.1 - 2.9e-05 23.5 0.3 4.1e-05 23.0 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDK86358.1 - 5.6e-05 22.6 0.1 0.00035 20.0 0.0 2.0 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 VDK86358.1 - 0.00071 19.2 0.5 0.001 18.7 0.5 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 VDK86358.1 - 0.0032 17.4 0.0 0.008 16.1 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 VDK86358.1 - 0.048 13.3 0.4 0.32 10.6 0.1 2.0 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 TTR-52 PF01060.23 VDK86359.1 - 4e-23 81.9 0.1 5.5e-23 81.5 0.1 1.2 1 0 0 1 1 1 1 Transthyretin-like family TIP41 PF04176.13 VDK86360.1 - 9.6e-57 191.2 0.0 1.9e-56 190.2 0.0 1.5 1 0 0 1 1 1 1 TIP41-like family ubiquitin PF00240.23 VDK86360.1 - 9.4e-15 54.1 0.0 2.1e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family BAG6 PF12057.8 VDK86360.1 - 8.4e-08 31.9 2.2 2.7e-06 27.0 0.4 2.6 2 0 0 2 2 2 1 BCL2-associated athanogene 6 Rad60-SLD PF11976.8 VDK86360.1 - 5.7e-05 22.9 0.1 0.00012 21.9 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like FERM_C PF09380.10 VDK86367.1 - 9.6e-20 70.8 0.2 1.9e-19 69.8 0.2 1.5 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_M PF00373.18 VDK86367.1 - 3.7e-19 69.3 0.1 9.9e-19 67.9 0.1 1.8 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 VDK86367.1 - 1.4e-13 50.5 0.1 3.6e-13 49.2 0.1 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FA PF08736.11 VDK86367.1 - 4.2e-11 42.7 7.2 1.5e-10 41.0 7.2 2.1 1 0 0 1 1 1 1 FERM adjacent (FA) Ufm1 PF03671.14 VDK86368.1 - 5.2e-43 145.0 0.1 6.2e-43 144.8 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Rhomboid PF01694.22 VDK86369.1 - 6.9e-38 130.0 11.6 6.9e-38 130.0 11.6 1.7 2 0 0 2 2 2 1 Rhomboid family EF-hand_7 PF13499.6 VDK86369.1 - 4.2e-12 46.4 0.2 7.3e-12 45.6 0.2 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 VDK86369.1 - 2.3e-10 39.2 0.2 0.00032 20.0 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 VDK86369.1 - 1.9e-08 33.5 0.3 0.0003 20.5 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 VDK86369.1 - 2e-07 30.7 0.8 1.6e-06 27.8 0.3 2.2 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 VDK86369.1 - 0.00097 19.4 0.0 0.0017 18.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 VDK86369.1 - 0.0047 16.4 0.2 0.38 10.3 0.0 2.5 2 0 0 2 2 2 1 EF hand TerB PF05099.13 VDK86369.1 - 0.059 13.3 0.0 0.095 12.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TerB Doppel PF11466.8 VDK86369.1 - 2.3 7.9 4.7 11 5.8 4.7 2.2 1 0 0 1 1 1 0 Prion-like protein Doppel DCB PF16213.5 VDK86370.1 - 1.1e-59 201.0 9.7 1.3e-59 200.8 9.7 1.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 AstB PF04996.12 VDK86370.1 - 0.037 12.7 0.3 0.058 12.1 0.3 1.2 1 0 0 1 1 1 0 Succinylarginine dihydrolase TetR_C_24 PF17932.1 VDK86370.1 - 0.11 12.7 0.5 6 7.2 0.1 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain ST7 PF04184.12 VDK86371.1 - 6.8e-256 849.9 1.2 1e-255 849.3 1.2 1.2 1 0 0 1 1 1 1 ST7 protein TPR_6 PF13174.6 VDK86371.1 - 0.00013 22.3 0.1 0.00076 20.0 0.1 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK86371.1 - 0.003 18.2 5.5 0.64 11.0 0.1 4.4 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK86371.1 - 0.013 15.6 0.0 0.37 11.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK86371.1 - 0.018 14.8 0.1 25 4.9 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Clathrin PF00637.20 VDK86371.1 - 0.019 14.8 0.1 0.038 13.9 0.1 1.4 1 0 0 1 1 1 0 Region in Clathrin and VPS TPR_16 PF13432.6 VDK86371.1 - 0.067 13.9 0.4 0.47 11.1 0.0 2.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK86371.1 - 0.39 11.3 4.3 2.3 8.8 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat Ion_trans_2 PF07885.16 VDK86372.1 - 3.4e-19 68.6 12.5 2.1e-15 56.4 6.8 2.4 1 1 1 2 2 2 2 Ion channel Ion_trans PF00520.31 VDK86372.1 - 4.9e-06 25.9 6.5 0.012 14.9 0.3 2.1 2 0 0 2 2 2 2 Ion transport protein EpsG PF14897.6 VDK86372.1 - 0.066 12.5 7.9 0.089 12.1 7.9 1.1 1 0 0 1 1 1 0 EpsG family DEAD PF00270.29 VDK86377.1 - 5.3e-37 127.3 0.0 1.4e-36 125.9 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK86377.1 - 8e-30 103.4 0.0 2e-28 99.0 0.0 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK86377.1 - 0.044 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF5335 PF17269.2 VDK86377.1 - 0.069 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5335) Mon1 PF03164.14 VDK86379.1 - 1.8e-82 277.6 2.6 2.4e-82 277.2 2.6 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Ribosomal_L2 PF00181.23 VDK86379.1 - 2.7e-17 62.5 0.0 4.7e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L2_C PF03947.18 VDK86379.1 - 3.5e-12 46.6 0.0 5.7e-11 42.7 0.0 2.4 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain CUB PF00431.20 VDK86383.1 - 1.9e-107 353.3 5.8 7.5e-32 109.9 0.1 5.4 5 0 0 5 5 5 5 CUB domain Astacin PF01400.24 VDK86383.1 - 2.6e-65 219.6 0.1 5e-65 218.7 0.1 1.4 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) FXa_inhibition PF14670.6 VDK86383.1 - 2.8e-21 75.5 33.0 1.2e-10 41.4 11.1 3.3 3 0 0 3 3 3 2 Coagulation Factor Xa inhibitory site EGF_CA PF07645.15 VDK86383.1 - 1.1e-14 54.4 32.1 2.6e-07 30.7 14.1 2.8 2 0 0 2 2 2 2 Calcium-binding EGF domain cEGF PF12662.7 VDK86383.1 - 1.2e-10 41.1 11.5 1.2e-05 25.1 1.1 3.8 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF PF00008.27 VDK86383.1 - 2.9e-07 30.7 22.5 0.00088 19.5 8.1 3.0 2 0 0 2 2 2 2 EGF-like domain EGF_3 PF12947.7 VDK86383.1 - 0.0003 20.9 32.1 0.018 15.3 12.0 3.1 2 0 0 2 2 2 2 EGF domain Reprolysin_4 PF13583.6 VDK86383.1 - 0.052 13.2 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 VDK86383.1 - 0.093 12.6 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 Matrixin hEGF PF12661.7 VDK86383.1 - 0.21 12.3 27.6 0.2 12.3 4.9 4.0 4 0 0 4 4 3 0 Human growth factor-like EGF EGF_MSP1_1 PF12946.7 VDK86383.1 - 2.6 8.2 25.1 0.05 13.7 5.6 3.6 3 0 0 3 3 3 0 MSP1 EGF domain 1 Chorion_3 PF05387.11 VDK86388.1 - 0.076 12.6 0.0 0.087 12.5 0.0 1.1 1 0 0 1 1 1 0 Chorion family 3 Clathrin PF00637.20 VDK86397.1 - 1.5e-12 47.6 10.7 6.8e-11 42.2 0.7 3.4 3 1 1 4 4 4 2 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 VDK86397.1 - 4.4e-05 23.4 10.2 0.00014 21.8 10.2 2.0 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 VDK86397.1 - 0.0003 20.6 8.1 0.00097 18.9 8.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK86397.1 - 0.00032 20.9 6.0 0.00032 20.9 6.0 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 VDK86397.1 - 0.00035 20.8 7.2 0.0019 18.5 7.2 2.4 1 0 0 1 1 1 1 Ring finger domain Vps39_1 PF10366.9 VDK86397.1 - 0.00079 19.7 3.1 0.023 15.0 0.5 3.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 zf-ANAPC11 PF12861.7 VDK86397.1 - 0.036 14.1 1.6 0.21 11.6 1.6 2.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_7 PF13176.6 VDK86397.1 - 0.047 13.7 0.6 10 6.4 0.2 3.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK86397.1 - 0.056 14.3 0.0 6.4 7.9 0.0 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 VDK86397.1 - 0.089 13.1 0.1 2.6 8.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK86397.1 - 0.11 12.8 4.1 5.2 7.4 0.0 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 VDK86397.1 - 0.48 10.7 3.0 0.65 10.3 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-C3HC4 PF00097.25 VDK86397.1 - 0.56 10.1 13.2 0.061 13.2 8.0 2.3 2 0 0 2 2 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK86397.1 - 0.84 9.7 3.8 2.7 8.1 3.8 2.0 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 VDK86397.1 - 1.6 8.8 13.9 0.069 13.1 7.3 2.3 2 0 0 2 2 1 0 zinc-RING finger domain TPR_8 PF13181.6 VDK86397.1 - 2.7 8.4 9.5 1.2 9.5 0.3 3.8 5 0 0 5 5 3 0 Tetratricopeptide repeat zf-C3HC4_3 PF13920.6 VDK86397.1 - 4 7.4 9.0 2.1 8.2 5.0 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CTP_transf_like PF01467.26 VDK86400.1 - 5e-49 166.2 0.1 4.9e-28 98.1 0.0 2.8 3 0 0 3 3 3 2 Cytidylyltransferase-like FAD_syn PF06574.12 VDK86400.1 - 0.0064 16.4 2.7 2.5 8.0 0.2 3.3 3 0 0 3 3 3 2 FAD synthetase zf-RING_2 PF13639.6 VDK86401.1 - 5.6e-13 49.0 10.9 5.6e-13 49.0 10.9 1.6 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.7 VDK86401.1 - 8.7e-10 38.7 8.5 1.8e-09 37.7 8.5 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 VDK86401.1 - 3.5e-07 29.8 9.4 3.5e-07 29.8 9.4 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 VDK86401.1 - 5.6e-07 29.3 9.9 9.3e-07 28.6 9.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK86401.1 - 1e-06 28.6 8.9 1.8e-06 27.8 8.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 VDK86401.1 - 1.8e-06 27.7 10.5 3.1e-06 26.9 10.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK86401.1 - 2.3e-05 24.2 9.5 3.8e-05 23.5 9.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK86401.1 - 3.2e-05 23.8 6.9 6.6e-05 22.9 6.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 VDK86401.1 - 0.00021 21.1 8.3 0.00038 20.2 8.3 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 VDK86401.1 - 0.00034 20.6 6.8 0.0012 18.9 6.8 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 VDK86401.1 - 0.094 12.3 7.8 0.16 11.6 7.8 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 VDK86401.1 - 1 9.6 7.2 2.9 8.1 7.2 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain Vps39_2 PF10367.9 VDK86401.1 - 1.6 9.2 6.0 0.33 11.4 2.2 1.8 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 RINGv PF12906.7 VDK86401.1 - 1.9 8.7 10.2 4.3 7.6 10.2 1.6 1 0 0 1 1 1 0 RING-variant domain Prok-RING_1 PF14446.6 VDK86401.1 - 2.9 7.9 11.1 15 5.6 6.1 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 VDK86401.1 - 4 7.3 8.7 12 5.8 8.7 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Abhydrolase_1 PF00561.20 VDK86405.1 - 7.9e-24 84.7 0.0 1e-23 84.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 VDK86405.1 - 1.4e-15 58.5 0.1 1.9e-15 58.1 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 VDK86405.1 - 1.6e-11 43.9 0.0 2.9e-11 43.1 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 VDK86405.1 - 0.0001 21.1 0.0 0.00016 20.5 0.0 1.2 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 VDK86405.1 - 0.0074 16.2 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase LIDHydrolase PF10230.9 VDK86405.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase PAF-AH_p_II PF03403.13 VDK86405.1 - 0.012 14.2 0.0 0.024 13.1 0.0 1.4 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II DUF915 PF06028.11 VDK86405.1 - 0.02 14.2 0.0 0.58 9.4 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_3 PF07859.13 VDK86405.1 - 0.056 13.3 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S28 PF05577.12 VDK86405.1 - 0.083 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Lipase_3 PF01764.25 VDK86405.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) eIF3_subunit PF08597.10 VDK86406.1 - 7e-21 75.2 12.8 9.6e-21 74.8 12.8 1.2 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Amino_oxidase PF01593.24 VDK86407.1 - 6.6e-14 52.0 0.0 8.8e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 VDK86407.1 - 1.5e-13 50.9 0.0 4.7e-13 49.3 0.0 1.9 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 VDK86407.1 - 1.4e-10 41.3 0.1 5.1e-10 39.4 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 VDK86407.1 - 8.3e-07 28.7 0.0 1.4e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 VDK86407.1 - 8.1e-06 25.3 0.0 1.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 VDK86407.1 - 9.3e-06 25.5 0.1 1.5e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 VDK86407.1 - 4.6e-05 22.3 0.4 7.2e-05 21.7 0.4 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 VDK86407.1 - 0.00014 21.1 0.9 0.00021 20.5 0.9 1.2 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 VDK86407.1 - 0.00014 21.2 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 VDK86407.1 - 0.00022 20.5 0.1 0.00043 19.5 0.1 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 VDK86407.1 - 0.0011 19.4 0.1 0.0034 17.9 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 VDK86407.1 - 0.0014 17.9 0.0 0.0023 17.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 VDK86407.1 - 0.0017 17.7 0.2 0.0038 16.5 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 VDK86407.1 - 0.0028 17.0 0.8 0.0048 16.2 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 VDK86407.1 - 0.033 13.2 0.2 0.047 12.7 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein TCR_zetazeta PF11628.8 VDK86407.1 - 0.19 11.4 0.1 0.19 11.4 0.1 2.5 3 0 0 3 3 2 0 T-cell surface glycoprotein CD3 zeta chain LRR_8 PF13855.6 VDK86408.1 - 7.9e-31 105.6 32.2 4.1e-10 39.3 4.5 5.9 3 1 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 VDK86408.1 - 1.3e-21 76.3 40.4 1.8e-06 28.2 0.2 6.5 4 2 1 6 6 6 6 Leucine Rich repeats (2 copies) TIR_2 PF13676.6 VDK86408.1 - 1.8e-08 35.0 0.0 6.3e-08 33.2 0.0 1.9 2 0 0 2 2 2 1 TIR domain LRR_5 PF13306.6 VDK86408.1 - 4.8e-08 33.0 0.7 0.0051 16.8 0.1 3.6 2 1 1 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 VDK86408.1 - 9e-06 25.3 1.2 9e-06 25.3 1.2 4.0 3 2 1 4 4 4 1 Leucine-rich repeat LRR_6 PF13516.6 VDK86408.1 - 1.3e-05 24.9 19.3 5.4 7.3 0.1 7.5 7 0 0 7 7 7 3 Leucine Rich repeat FNIP PF05725.12 VDK86408.1 - 0.0038 17.3 0.8 4.6 7.5 0.0 3.8 2 2 1 3 3 3 1 FNIP Repeat TIR PF01582.20 VDK86408.1 - 0.0042 16.9 0.2 0.0071 16.2 0.2 1.3 1 0 0 1 1 1 1 TIR domain LRR_1 PF00560.33 VDK86408.1 - 0.036 14.6 27.9 3.5 8.5 0.3 9.4 8 2 0 8 8 8 0 Leucine Rich Repeat LIM PF00412.22 VDK86412.1 - 4.2e-20 71.7 20.2 6.2e-13 48.8 6.7 2.2 2 0 0 2 2 2 2 LIM domain DUF2321 PF10083.9 VDK86412.1 - 0.11 12.1 12.1 3.5 7.2 8.6 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Cript PF10235.9 VDK86412.1 - 0.48 11.0 11.8 1.9 9.1 2.5 2.7 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT PolC_DP2 PF03833.13 VDK86412.1 - 1.8 6.3 3.3 2.4 5.9 3.3 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 XPA_N PF01286.18 VDK86412.1 - 3 8.0 14.9 16 5.6 0.0 4.3 4 1 0 4 4 4 0 XPA protein N-terminal adh_short PF00106.25 VDK86413.1 - 8.9e-45 152.6 1.3 1.3e-44 152.0 1.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK86413.1 - 4.6e-29 101.6 0.4 6.9e-29 101.1 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK86413.1 - 4.1e-05 23.6 0.3 6.5e-05 22.9 0.3 1.2 1 0 0 1 1 1 1 KR domain DUF745 PF05335.13 VDK86413.1 - 0.032 14.0 0.2 0.05 13.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF1082 PF06449.11 VDK86413.1 - 0.06 13.2 0.7 6.4 6.7 0.0 3.2 3 0 0 3 3 3 0 Mitochondrial domain of unknown function (DUF1082) DAGK_acc PF00609.19 VDK86414.1 - 1.2e-35 123.2 0.0 2.3e-35 122.3 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 VDK86414.1 - 2.6e-22 78.8 0.0 5.1e-22 77.8 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain C1_1 PF00130.22 VDK86414.1 - 1.1e-05 25.2 6.5 2.3e-05 24.2 6.5 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4196 PF13846.6 VDK86414.1 - 0.0013 18.9 3.8 0.0032 17.7 3.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4196) NAD_kinase PF01513.21 VDK86414.1 - 0.054 12.7 0.0 0.09 11.9 0.0 1.4 1 0 0 1 1 1 0 ATP-NAD kinase DAP_B PF07930.12 VDK86414.1 - 0.065 13.2 1.4 0.12 12.4 1.4 1.3 1 0 0 1 1 1 0 D-aminopeptidase, domain B C1_2 PF03107.16 VDK86414.1 - 0.12 12.7 7.9 0.27 11.6 7.9 1.6 1 0 0 1 1 1 0 C1 domain TUDOR PF00567.24 VDK86417.1 - 4.4e-39 133.3 0.2 1.1e-13 51.2 0.0 4.3 4 0 0 4 4 4 3 Tudor domain zf-CCHC PF00098.23 VDK86417.1 - 2.5e-05 24.1 1.0 7.2e-05 22.7 1.0 1.9 1 0 0 1 1 1 1 Zinc knuckle Agenet PF05641.12 VDK86417.1 - 0.0058 17.1 0.9 10 6.7 0.0 3.4 3 0 0 3 3 3 2 Agenet domain Tudor_3 PF18115.1 VDK86417.1 - 0.032 14.1 0.2 1.4 8.8 0.0 3.2 3 0 0 3 3 3 0 DNA repair protein Crb2 Tudor domain Toprim_Crpt PF13342.6 VDK86417.1 - 0.044 13.8 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase zf-CCHC_2 PF13696.6 VDK86417.1 - 0.3 10.9 3.0 0.27 11.1 0.9 2.0 2 0 0 2 2 2 0 Zinc knuckle Tudor-knot PF11717.8 VDK86417.1 - 1.3 9.0 3.2 0.83 9.6 0.2 2.2 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain Glyco_transf_64 PF09258.10 VDK86419.1 - 2.7e-70 236.4 0.2 4.5e-70 235.7 0.2 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Exostosin PF03016.15 VDK86419.1 - 1.4e-14 54.1 0.0 1.7e-12 47.2 0.0 2.8 1 1 0 1 1 1 1 Exostosin family DUF1690 PF07956.11 VDK86420.1 - 0.00065 20.1 8.1 0.0025 18.2 8.1 1.9 1 1 0 1 1 1 1 Protein of Unknown function (DUF1690) MTCP1 PF08991.10 VDK86420.1 - 0.049 13.9 1.1 0.11 12.8 1.1 1.6 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type CmlA_N PF18456.1 VDK86420.1 - 0.092 12.0 0.6 0.13 11.5 0.5 1.3 1 1 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain CX9C PF16860.5 VDK86420.1 - 0.13 12.3 1.0 0.31 11.1 1.0 1.6 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, kleA_kleC PF17383.2 VDK86420.1 - 0.47 10.8 2.0 3.5 8.0 0.0 2.7 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A GMP_PDE_delta PF05351.11 VDK86421.1 - 1e-43 149.1 0.0 1.6e-43 148.4 0.0 1.3 1 1 0 1 1 1 1 GMP-PDE, delta subunit Acyltransferase PF01553.21 VDK86423.1 - 3e-25 88.4 0.0 5e-25 87.7 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 VDK86423.1 - 4.6e-10 39.5 0.2 9.3e-10 38.5 0.2 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus zf-RING_5 PF14634.6 VDK86424.1 - 3.3e-08 33.3 11.5 8e-08 32.1 11.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK86424.1 - 0.001 18.9 7.5 0.001 18.9 7.5 2.4 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 EST1_DNA_bind PF10373.9 VDK86424.1 - 0.0058 16.2 2.1 0.0098 15.4 2.1 1.3 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain zf-RING_2 PF13639.6 VDK86424.1 - 0.0067 16.7 10.0 0.016 15.5 10.0 1.7 1 0 0 1 1 1 1 Ring finger domain Beach PF02138.18 VDK86424.1 - 0.013 14.9 1.6 0.58 9.5 1.6 2.2 1 1 0 1 1 1 0 Beige/BEACH domain Orthoreo_P17 PF07272.11 VDK86424.1 - 0.031 14.3 0.1 0.056 13.5 0.1 1.5 1 0 0 1 1 1 0 Orthoreovirus P17 protein zf-C3HC4 PF00097.25 VDK86424.1 - 0.039 13.8 10.8 0.17 11.8 10.8 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 VDK86424.1 - 0.047 13.6 7.3 0.21 11.5 7.4 2.1 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 VDK86424.1 - 0.053 13.6 7.1 0.36 10.9 7.1 2.4 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDK86424.1 - 0.094 12.6 9.8 0.067 13.0 6.2 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Retrotrans_gag PF03732.17 VDK86425.1 - 0.076 13.3 0.2 0.14 12.5 0.2 1.4 1 0 0 1 1 1 0 Retrotransposon gag protein Steroid_dh PF02544.16 VDK86426.1 - 0.0061 16.5 2.2 0.012 15.6 0.0 2.3 3 0 0 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase Steroid_dh PF02544.16 VDK86427.1 - 2e-44 151.2 0.5 2.2e-44 151.0 0.5 1.0 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 VDK86427.1 - 0.00096 18.7 0.1 0.00096 18.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) IZUMO PF15005.6 VDK86428.1 - 0.82 10.2 4.3 0.23 12.0 0.3 2.1 3 0 0 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Img2 PF05046.14 VDK86429.1 - 2e-15 56.9 0.0 3.9e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DUF3613 PF12266.8 VDK86430.1 - 0.0055 16.4 1.0 0.0098 15.7 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3613) DUF4570 PF15134.6 VDK86430.1 - 0.067 13.2 0.8 0.13 12.3 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) MMR_HSR1_Xtn PF16897.5 VDK86430.1 - 0.092 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain PI3_PI4_kinase PF00454.27 VDK86431.1 - 3.9e-52 177.5 0.0 7.4e-52 176.6 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 VDK86431.1 - 8.4e-25 87.7 1.4 2.7e-24 86.0 1.3 1.9 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 VDK86431.1 - 1.7e-12 46.9 0.0 4.4e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 FATC domain UME PF08064.13 VDK86431.1 - 0.001 18.9 0.1 0.0045 16.9 0.1 2.2 2 0 0 2 2 2 1 UME (NUC010) domain TPR_19 PF14559.6 VDK86431.1 - 0.045 14.3 1.6 1.7 9.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3385 PF11865.8 VDK86431.1 - 0.14 12.0 0.1 1.4 8.8 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) Nebulin PF00880.18 VDK86434.1 - 5.4e-17 61.3 7.3 1.9e-11 43.7 0.2 2.5 3 0 0 3 3 3 2 Nebulin repeat AbiTii PF18864.1 VDK86434.1 - 0.013 15.6 0.1 0.014 15.6 0.1 1.0 1 0 0 1 1 1 0 AbiTii DUF3029 PF11230.8 VDK86434.1 - 0.016 13.6 0.0 0.019 13.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) EMI PF07546.13 VDK86437.1 - 1.4 9.7 4.3 1.8 9.4 1.7 2.4 3 0 0 3 3 3 0 EMI domain Las1 PF04031.13 VDK86438.1 - 9.7e-34 116.7 2.1 9.7e-34 116.7 2.1 2.0 2 0 0 2 2 2 1 Las1-like Imm26 PF15428.6 VDK86438.1 - 0.043 14.1 0.2 2.7 8.2 0.0 3.1 3 0 0 3 3 3 0 Immunity protein 26 TAN PF11640.8 VDK86438.1 - 0.21 11.7 3.7 0.3 11.2 1.0 2.4 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair START PF01852.19 VDK86439.1 - 2.8e-28 98.8 0.3 4.3e-28 98.2 0.3 1.2 1 0 0 1 1 1 1 START domain PH PF00169.29 VDK86439.1 - 1.6e-11 44.6 0.8 6e-11 42.8 0.8 2.0 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 VDK86439.1 - 3e-06 27.4 0.9 3e-06 27.4 0.9 2.4 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 VDK86439.1 - 0.00064 20.1 4.6 0.00064 20.1 4.6 2.9 1 1 1 2 2 2 1 Pleckstrin homology domain YARHG PF13308.6 VDK86439.1 - 0.078 12.9 0.2 16 5.5 0.1 2.7 2 0 0 2 2 2 0 YARHG domain CLTH PF10607.9 VDK86447.1 - 1.5e-28 99.6 1.0 1.9e-28 99.2 1.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 VDK86447.1 - 0.00029 20.7 0.1 0.0009 19.1 0.1 1.9 1 0 0 1 1 1 1 LisH ELYS PF13934.6 VDK86447.1 - 0.016 15.2 0.2 0.04 13.9 0.1 1.6 1 1 1 2 2 2 0 Nuclear pore complex assembly HMG_box PF00505.19 VDK86448.1 - 1.4e-10 41.5 0.5 2.9e-10 40.4 0.5 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK86448.1 - 2.2e-06 28.2 1.6 4.9e-06 27.1 1.6 1.5 1 0 0 1 1 1 1 HMG-box domain RRM_7 PF16367.5 VDK86449.1 - 9.6e-39 131.4 0.0 1.7e-36 124.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif CEBP_ZZ PF16366.5 VDK86449.1 - 2.8e-21 75.5 8.6 8.1e-21 74.0 8.6 1.9 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 VDK86449.1 - 5.1e-13 48.6 0.0 3.1e-05 23.7 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LCE6A PF15858.5 VDK86449.1 - 3.9 8.3 9.3 0.5 11.2 2.8 2.4 2 0 0 2 2 2 0 Late cornified envelope protein 6A family Kelch_1 PF01344.25 VDK86453.1 - 5e-46 154.0 6.8 1.3e-09 37.4 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 VDK86453.1 - 5.7e-17 61.3 0.5 0.0053 17.0 0.0 5.6 2 2 3 5 5 5 4 Kelch motif Kelch_4 PF13418.6 VDK86453.1 - 7.8e-13 48.2 0.8 0.0091 16.0 0.0 5.2 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 VDK86453.1 - 3.3e-10 39.5 1.8 0.16 12.0 0.0 5.9 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 VDK86453.1 - 2e-07 31.1 4.5 0.073 13.4 0.1 5.8 6 0 0 6 6 6 2 Galactose oxidase, central domain BACK PF07707.15 VDK86453.1 - 0.00016 21.7 0.1 0.0004 20.4 0.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch Kelch_5 PF13854.6 VDK86453.1 - 0.013 15.5 10.6 4.2 7.5 0.0 5.7 6 0 0 6 6 6 0 Kelch motif CENP-B_N PF04218.13 VDK86457.1 - 1.1e-09 37.8 0.2 1.9e-09 37.0 0.2 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_23 PF13384.6 VDK86457.1 - 0.0038 17.0 1.0 0.0084 15.9 1.0 1.6 1 1 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.6 VDK86457.1 - 0.015 15.1 0.3 0.024 14.4 0.3 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.6 VDK86457.1 - 0.016 14.8 0.1 0.027 14.0 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF2481 PF10654.9 VDK86457.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) COX4 PF02936.14 VDK86457.1 - 0.025 14.6 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV HTH_IclR PF09339.10 VDK86457.1 - 0.034 13.9 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain Sigma70_r4 PF04545.16 VDK86457.1 - 0.077 12.5 0.3 0.23 11.0 0.1 1.8 1 1 1 2 2 2 0 Sigma-70, region 4 UPF0122 PF04297.14 VDK86457.1 - 0.095 13.0 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Putative helix-turn-helix protein, YlxM / p13 like MarR PF01047.22 VDK86457.1 - 0.6 10.1 0.1 0.6 10.1 0.1 2.3 3 0 0 3 3 3 0 MarR family HTH_32 PF13565.6 VDK86457.1 - 0.9 10.2 5.2 1.7 9.3 0.1 2.3 2 0 0 2 2 2 0 Homeodomain-like domain zf-C2H2_4 PF13894.6 VDK86459.1 - 0.52 11.3 5.7 0.76 10.8 1.9 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 VDK86459.1 - 6.2 7.2 9.6 0.29 11.5 2.2 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DBR1 PF05011.13 VDK86460.1 - 2.6e-32 112.2 0.1 3.9e-32 111.6 0.1 1.2 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Apolipo_F PF15148.6 VDK86461.1 - 0.043 13.3 0.0 0.08 12.4 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein F SMC_Nse1 PF07574.13 VDK86463.1 - 4.2e-05 23.5 0.3 8.3e-05 22.6 0.3 1.5 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex Prok-RING_1 PF14446.6 VDK86463.1 - 0.0012 18.7 3.4 0.0012 18.7 3.4 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 C1_1 PF00130.22 VDK86463.1 - 0.0026 17.6 7.1 0.0026 17.6 7.1 1.9 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE_2 PF02318.16 VDK86463.1 - 0.012 15.9 5.8 0.012 15.9 5.8 2.3 1 1 1 2 2 2 0 FYVE-type zinc finger Vps36-NZF-N PF16988.5 VDK86463.1 - 0.044 13.2 0.5 0.5 9.8 0.1 2.4 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain RL PF17797.1 VDK86463.1 - 0.055 13.4 0.8 0.12 12.3 0.8 1.6 1 0 0 1 1 1 0 RL domain PHD PF00628.29 VDK86463.1 - 0.12 12.2 12.5 0.11 12.5 7.2 2.8 2 1 1 3 3 3 0 PHD-finger zf-RING_2 PF13639.6 VDK86463.1 - 2.5 8.5 10.9 0.53 10.7 6.1 2.2 2 0 0 2 2 2 0 Ring finger domain Kinesin PF00225.23 VDK86471.1 - 7.3e-117 390.0 0.1 1.9e-116 388.7 0.1 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 VDK86471.1 - 1.6e-27 96.3 0.2 8.8e-27 93.9 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding TBCC_N PF16752.5 VDK86471.1 - 0.0035 17.8 10.0 0.0035 17.8 10.0 3.1 2 1 1 3 3 3 1 Tubulin-specific chaperone C N-terminal domain Kinesin_assoc PF16183.5 VDK86471.1 - 0.045 13.9 14.8 0.013 15.7 9.1 2.8 3 1 0 3 3 3 0 Kinesin-associated AAA_16 PF13191.6 VDK86471.1 - 0.13 12.6 0.0 0.13 12.6 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain eIF3_N PF09440.10 VDK86471.1 - 2 8.8 14.8 0.3 11.5 7.6 2.9 1 1 2 3 3 3 0 eIF3 subunit 6 N terminal domain FUSC PF04632.12 VDK86471.1 - 6.4 5.2 5.5 10 4.5 5.5 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Phlebovirus_G2 PF07245.11 VDK86472.1 - 0.0056 15.2 0.6 0.0065 15.0 0.6 1.0 1 0 0 1 1 1 1 Phlebovirus glycoprotein G2 TMIE PF16038.5 VDK86472.1 - 0.015 15.1 0.4 0.022 14.6 0.4 1.3 1 0 0 1 1 1 0 TMIE protein ELO PF01151.18 VDK86473.1 - 1.6e-63 214.5 24.0 1.9e-63 214.3 24.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Carm_PH PF17888.1 VDK86480.1 - 6e-24 84.2 0.3 3.9e-23 81.6 0.3 2.3 1 1 0 1 1 1 1 Carmil pleckstrin homology domain LRR_4 PF12799.7 VDK86480.1 - 0.0011 19.4 29.7 0.1 13.0 3.8 6.1 5 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 VDK86480.1 - 0.051 13.6 26.8 5.5 7.3 0.0 8.3 9 0 0 9 9 9 0 Leucine Rich repeat zf-A20 PF01754.16 VDK86484.1 - 7.8e-13 48.1 6.2 7.8e-13 48.1 6.2 2.4 3 0 0 3 3 3 1 A20-like zinc finger zf-AN1 PF01428.16 VDK86484.1 - 6.1e-09 35.9 7.6 6.1e-09 35.9 7.6 2.5 2 0 0 2 2 2 1 AN1-like Zinc finger zf-C5HC2 PF02928.16 VDK86484.1 - 0.049 14.0 6.1 0.051 14.0 3.8 2.2 2 0 0 2 2 2 0 C5HC2 zinc finger Filament PF00038.21 VDK86494.1 - 2.1e-69 234.5 54.0 2.1e-68 231.2 54.0 2.0 1 1 0 1 1 1 1 Intermediate filament protein APG6_N PF17675.1 VDK86494.1 - 9.5e-06 26.2 49.4 0.38 11.3 5.1 5.9 2 1 3 5 5 5 3 Apg6 coiled-coil region DUF2353 PF09789.9 VDK86494.1 - 3.8e-05 23.2 15.9 3.8e-05 23.2 15.9 3.1 1 1 1 2 2 1 1 Uncharacterized coiled-coil protein (DUF2353) Myosin_tail_1 PF01576.19 VDK86494.1 - 7e-05 20.9 44.4 0.013 13.4 17.9 2.5 1 1 1 2 2 2 2 Myosin tail TPR_MLP1_2 PF07926.12 VDK86494.1 - 0.00094 19.2 42.9 0.017 15.2 11.5 5.4 1 1 3 4 4 4 3 TPR/MLP1/MLP2-like protein PEARLI-4 PF05278.12 VDK86494.1 - 0.0031 17.2 17.5 0.024 14.3 1.5 3.4 3 0 0 3 3 3 2 Arabidopsis phospholipase-like protein (PEARLI 4) ERM PF00769.19 VDK86494.1 - 0.0046 16.8 20.3 0.0046 16.8 20.3 3.2 1 1 1 3 3 3 1 Ezrin/radixin/moesin family Metal_resist PF13801.6 VDK86494.1 - 0.0053 16.9 1.8 0.0053 16.9 1.8 3.6 4 1 0 4 4 3 1 Heavy-metal resistance GAS PF13851.6 VDK86494.1 - 0.0081 15.5 8.9 0.0081 15.5 8.9 3.9 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 VDK86494.1 - 0.011 15.4 44.7 0.085 12.5 19.7 3.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 VDK86494.1 - 0.024 13.5 39.7 0.041 12.8 12.2 3.1 1 1 1 3 3 3 0 Spc7 kinetochore protein Herpes_UL6 PF01763.16 VDK86494.1 - 0.03 12.8 20.6 0.11 11.1 2.4 3.1 1 1 1 3 3 3 0 Herpesvirus UL6 like KASH_CCD PF14662.6 VDK86494.1 - 0.061 13.2 42.7 0.46 10.3 17.5 3.6 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH FlaC_arch PF05377.11 VDK86494.1 - 0.094 13.1 19.0 0.096 13.1 0.3 5.6 5 1 1 6 6 4 0 Flagella accessory protein C (FlaC) MRPL52 PF18699.1 VDK86494.1 - 0.11 12.7 16.1 0.42 10.8 1.7 4.2 4 0 0 4 4 3 0 Mitoribosomal protein mL52 Prominin PF05478.11 VDK86494.1 - 0.11 10.4 24.2 0.32 8.9 3.2 2.7 1 1 0 2 2 2 0 Prominin CENP-F_leu_zip PF10473.9 VDK86494.1 - 0.15 12.1 45.9 0.5 10.4 14.9 4.2 2 2 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.11 VDK86494.1 - 0.18 12.0 8.0 0.4 11.0 0.1 4.1 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) SOGA PF11365.8 VDK86494.1 - 0.2 12.8 34.3 0.44 11.7 2.9 6.3 1 1 5 6 6 6 0 Protein SOGA FPP PF05911.11 VDK86494.1 - 0.25 9.5 33.8 0.22 9.7 11.4 2.3 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil SNCAIP_SNCA_bd PF16700.5 VDK86494.1 - 0.41 10.4 6.1 0.16 11.7 0.4 3.2 3 0 0 3 3 3 0 Synphilin-1 alpha-Synuclein-binding domain Gp58 PF07902.11 VDK86494.1 - 0.47 8.7 16.1 1.6 6.9 16.1 1.8 1 1 0 1 1 1 0 gp58-like protein DUF3584 PF12128.8 VDK86494.1 - 0.72 7.3 41.3 0.13 9.7 37.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Uso1_p115_C PF04871.13 VDK86494.1 - 0.85 10.0 36.2 0.032 14.6 9.4 4.3 2 2 3 5 5 5 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1664 PF07889.12 VDK86494.1 - 1 9.4 21.5 0.18 11.9 1.7 4.5 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 VDK86494.1 - 1.3 9.1 42.9 3.6 7.6 14.2 3.4 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF4201 PF13870.6 VDK86494.1 - 1.5 8.6 46.6 0.87 9.3 3.9 5.0 2 1 1 4 4 4 0 Domain of unknown function (DUF4201) Prefoldin_2 PF01920.20 VDK86494.1 - 1.6 8.7 33.4 0.42 10.6 0.5 5.9 3 2 2 5 5 5 0 Prefoldin subunit DHR10 PF18595.1 VDK86494.1 - 2 8.5 50.0 0.16 12.1 10.8 5.3 3 2 0 4 4 4 0 Designed helical repeat protein 10 domain TSC22 PF01166.18 VDK86494.1 - 2.2 8.7 28.4 0.47 10.8 1.4 6.2 4 2 2 6 6 6 0 TSC-22/dip/bun family FAP206 PF12018.8 VDK86494.1 - 2.4 7.6 21.5 0.055 13.0 0.9 3.8 1 1 0 3 3 3 0 Domain of unknown function Golgin_A5 PF09787.9 VDK86494.1 - 2.7 7.4 45.3 0.73 9.2 15.3 3.8 1 1 4 5 5 5 0 Golgin subfamily A member 5 Fez1 PF06818.15 VDK86494.1 - 2.8 8.4 43.3 3.5 8.0 8.3 3.9 1 1 2 3 3 3 0 Fez1 CCDC144C PF14915.6 VDK86494.1 - 4.2 6.4 42.9 3.1 6.8 8.2 3.2 1 1 2 3 3 3 0 CCDC144C protein coiled-coil region YabA PF06156.13 VDK86494.1 - 4.4 8.0 35.7 1.4 9.6 2.0 5.7 1 1 5 6 6 6 0 Initiation control protein YabA MAD PF05557.13 VDK86494.1 - 4.5 5.5 49.0 4.3 5.6 20.5 3.2 1 1 2 3 3 3 0 Mitotic checkpoint protein DUF3450 PF11932.8 VDK86494.1 - 7.6 5.8 34.4 0.047 13.0 2.8 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) TPR_5 PF12688.7 VDK86494.1 - 7.8 6.8 8.3 6.7 7.0 3.1 2.9 2 1 1 3 3 2 0 Tetratrico peptide repeat Snapin_Pallidin PF14712.6 VDK86494.1 - 7.9 7.0 28.7 0.15 12.5 4.1 4.6 4 3 1 5 5 4 0 Snapin/Pallidin DUF2407_C PF13373.6 VDK86494.1 - 9.2 6.4 9.3 0.4 10.8 2.0 2.6 1 1 0 2 2 2 0 DUF2407 C-terminal domain TMF_TATA_bd PF12325.8 VDK86494.1 - 9.7 6.4 47.0 0.79 10.0 4.7 5.8 1 1 3 5 5 5 0 TATA element modulatory factor 1 TATA binding DHHC PF01529.20 VDK86496.1 - 4e-34 117.6 8.0 4e-34 117.6 8.0 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase FYVE PF01363.21 VDK86496.1 - 0.008 16.3 11.1 0.016 15.4 11.1 1.4 1 0 0 1 1 1 1 FYVE zinc finger LapA_dom PF06305.11 VDK86496.1 - 0.03 14.1 1.3 0.12 12.3 1.3 2.0 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain OB_NTP_bind PF07717.16 VDK86499.1 - 6.6e-14 52.0 0.0 2e-13 50.5 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 VDK86499.1 - 6.7e-14 52.1 0.1 6.7e-14 52.1 0.1 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) DEAD PF00270.29 VDK86499.1 - 3.9e-10 39.8 0.4 9.8e-10 38.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK86499.1 - 5.5e-10 39.6 0.2 4.1e-09 36.8 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 VDK86499.1 - 1.6e-05 25.2 0.0 0.00012 22.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK86499.1 - 0.0029 17.4 0.0 0.006 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain CUE PF02845.16 VDK86499.1 - 0.0047 16.6 0.0 0.012 15.3 0.0 1.8 1 0 0 1 1 1 1 CUE domain AAA_19 PF13245.6 VDK86499.1 - 0.0099 16.2 0.0 0.027 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 VDK86499.1 - 0.01 15.8 0.7 2.6 7.9 0.1 3.0 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 VDK86499.1 - 0.018 14.1 0.0 0.039 13.0 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Flavi_DEAD PF07652.14 VDK86499.1 - 0.077 13.0 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain S1FA PF04689.13 VDK86499.1 - 0.13 12.4 0.2 2.3 8.4 0.5 2.7 2 0 0 2 2 2 0 DNA binding protein S1FA ResIII PF04851.15 VDK86499.1 - 0.19 11.7 4.6 0.19 11.7 0.1 3.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_23 PF13476.6 VDK86499.1 - 0.6 10.6 0.0 0.6 10.6 0.0 3.9 5 0 0 5 5 4 0 AAA domain Sdh_cyt PF01127.22 VDK86500.1 - 3.7e-18 65.7 3.8 5.3e-18 65.2 3.8 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Bcl-2 PF00452.19 VDK86501.1 - 4e-11 43.5 0.2 1e-10 42.2 0.1 1.7 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.17 VDK86501.1 - 0.031 14.1 0.6 0.075 12.9 0.6 1.6 1 0 0 1 1 1 0 Bcl-2 homology region 4 Bcl-2 PF00452.19 VDK86502.1 - 7.4e-13 49.0 0.3 1.4e-12 48.1 0.1 1.5 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family BH4 PF02180.17 VDK86502.1 - 0.082 12.7 0.9 0.58 10.0 0.5 2.3 2 1 0 2 2 2 0 Bcl-2 homology region 4 Radical_SAM PF04055.21 VDK86504.1 - 0.1 12.9 0.1 0.12 12.7 0.1 1.1 1 0 0 1 1 1 0 Radical SAM superfamily DUF3591 PF12157.8 VDK86505.1 - 2.5e-149 497.7 0.0 4.4e-149 496.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) Bromodomain PF00439.25 VDK86505.1 - 2.8e-36 123.4 4.6 1.5e-17 63.4 0.6 2.8 2 0 0 2 2 2 2 Bromodomain zf-CCHC_6 PF15288.6 VDK86505.1 - 1.5e-05 24.8 1.4 4.1e-05 23.3 1.4 1.8 1 0 0 1 1 1 1 Zinc knuckle VWA PF00092.28 VDK86508.1 - 1.5e-57 194.7 13.1 8.6e-23 81.5 0.8 4.3 4 0 0 4 4 4 4 von Willebrand factor type A domain VWA_2 PF13519.6 VDK86508.1 - 2.2e-30 105.4 2.2 3.4e-11 43.7 0.1 4.6 4 0 0 4 4 4 4 von Willebrand factor type A domain VWA_3 PF13768.6 VDK86508.1 - 3.1e-10 40.2 1.1 0.0097 15.9 0.0 4.8 4 1 0 4 4 4 3 von Willebrand factor type A domain FXa_inhibition PF14670.6 VDK86508.1 - 5.5e-07 29.8 8.7 5.5e-07 29.8 8.7 2.3 3 0 0 3 3 3 1 Coagulation Factor Xa inhibitory site fn3 PF00041.21 VDK86508.1 - 0.00014 22.1 0.1 0.00043 20.6 0.1 1.8 1 0 0 1 1 1 1 Fibronectin type III domain EGF_CA PF07645.15 VDK86508.1 - 0.0004 20.5 5.6 0.0004 20.5 5.6 2.4 2 0 0 2 2 2 1 Calcium-binding EGF domain Ssl1 PF04056.14 VDK86508.1 - 0.0015 18.3 1.7 0.85 9.4 0.0 3.6 4 0 0 4 4 4 1 Ssl1-like DUF3048 PF11258.8 VDK86508.1 - 0.074 13.1 0.2 1 9.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3048) N-terminal domain Myb_DNA-binding PF00249.31 VDK86511.1 - 5.8e-08 32.8 1.5 2.3e-06 27.7 0.4 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF1851 PF08906.11 VDK86511.1 - 0.17 11.9 0.8 0.6 10.1 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1851) SPACA9 PF15120.6 VDK86511.1 - 0.54 10.0 4.4 1 9.2 4.4 1.4 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 SET PF00856.28 VDK86512.1 - 5.5e-18 65.9 1.7 5.5e-18 65.9 1.7 3.3 3 2 1 4 4 4 1 SET domain BAH PF01426.18 VDK86512.1 - 1.7e-12 47.2 1.8 4.3e-12 46.0 0.1 2.4 2 0 0 2 2 2 1 BAH domain PHD PF00628.29 VDK86512.1 - 4.3e-07 29.7 8.5 4.3e-07 29.7 8.5 2.5 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 VDK86512.1 - 0.0087 15.6 1.9 0.027 14.0 1.9 1.9 1 0 0 1 1 1 1 PHD-finger AWS PF17907.1 VDK86512.1 - 0.012 15.6 13.4 0.047 13.7 13.4 2.1 1 0 0 1 1 1 0 AWS domain C1_2 PF03107.16 VDK86512.1 - 0.41 11.0 9.2 1.6 9.1 5.4 3.1 2 0 0 2 2 2 0 C1 domain TFIIA PF03153.13 VDK86513.1 - 8.1 6.3 7.9 10 6.0 7.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Suf PF05843.14 VDK86516.1 - 0.71 9.8 4.6 1 9.3 4.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CAP_N PF01213.19 VDK86516.1 - 2.2 7.7 18.1 4 6.8 18.1 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF2076 PF09849.9 VDK86516.1 - 4 7.4 20.0 0.43 10.6 10.9 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) PRIMA1 PF16101.5 VDK86516.1 - 5.3 7.1 21.1 12 6.0 21.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 VDK86516.1 - 8.2 6.4 20.8 0.29 11.2 14.5 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator Homeodomain PF00046.29 VDK86517.1 - 2.2e-12 46.6 0.5 3.1e-12 46.2 0.5 1.2 1 0 0 1 1 1 1 Homeodomain S4 PF01479.25 VDK86517.1 - 0.036 13.8 0.9 0.1 12.4 0.9 1.8 1 1 0 1 1 1 0 S4 domain Homeodomain PF00046.29 VDK86518.1 - 0.00021 21.1 2.0 0.00039 20.2 2.0 1.5 1 0 0 1 1 1 1 Homeodomain Presenilin PF01080.17 VDK86518.1 - 0.7 8.6 1.8 0.86 8.3 1.8 1.1 1 0 0 1 1 1 0 Presenilin zf-BED PF02892.15 VDK86524.1 - 1.7e-05 24.8 0.7 3.7e-05 23.7 0.7 1.6 1 0 0 1 1 1 1 BED zinc finger FSA_C PF10479.9 VDK86524.1 - 0.028 12.6 0.3 0.04 12.1 0.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Med4 PF10018.9 VDK86524.1 - 0.077 12.7 0.6 0.14 11.8 0.6 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 zf-C2H2 PF00096.26 VDK86525.1 - 2.4e-16 59.2 76.4 0.014 15.8 3.4 10.2 9 0 0 9 9 9 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK86525.1 - 5.8e-16 57.8 79.5 0.0062 17.3 0.7 11.2 11 0 0 11 11 11 8 C2H2-type zinc finger TUDOR PF00567.24 VDK86525.1 - 2.1e-08 34.2 0.0 6.2e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 Tudor domain RRM_1 PF00076.22 VDK86525.1 - 1.7e-07 31.0 0.0 8e-07 28.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_aberr PF17017.5 VDK86525.1 - 0.0003 21.0 2.5 0.0003 21.0 2.5 5.3 4 1 0 5 5 5 2 Aberrant zinc-finger zf-H2C2_2 PF13465.6 VDK86525.1 - 0.0021 18.4 1.5 0.0021 18.4 1.5 8.6 9 0 0 9 9 8 4 Zinc-finger double domain zf-C2H2_jaz PF12171.8 VDK86525.1 - 0.014 15.7 1.2 0.014 15.7 1.2 7.4 8 0 0 8 8 6 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 VDK86525.1 - 0.03 14.1 0.7 0.03 14.1 0.7 7.5 8 1 0 8 8 6 0 C2H2-type zinc-finger domain T2SS-T3SS_pil_N PF13629.6 VDK86525.1 - 0.062 13.0 0.0 2.7 7.8 0.0 2.5 2 0 0 2 2 2 0 Pilus formation protein N terminal region FBD PF08387.10 VDK86525.1 - 0.097 12.6 0.0 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 FBD zf-C2H2_2 PF12756.7 VDK86525.1 - 0.27 11.6 44.2 2.8 8.3 1.6 7.6 2 1 4 6 6 6 0 C2H2 type zinc-finger (2 copies) Cys_rich_CPXG PF14255.6 VDK86525.1 - 0.48 10.4 5.9 20 5.2 0.8 4.0 3 0 0 3 3 3 0 Cysteine-rich CPXCG Evr1_Alr PF04777.13 VDK86531.1 - 7.9e-16 58.4 0.8 1.1e-15 57.9 0.1 1.5 2 0 0 2 2 2 1 Erv1 / Alr family UPF0029 PF01205.19 VDK86532.1 - 6.7e-35 119.6 0.1 1.2e-34 118.8 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 VDK86532.1 - 4.4e-11 43.1 6.5 1e-09 38.7 5.1 2.5 2 1 0 2 2 2 1 RWD domain DUF2922 PF11148.8 VDK86532.1 - 0.024 14.4 0.0 0.14 11.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) YacG PF03884.14 VDK86533.1 - 0.012 15.3 0.8 0.025 14.3 0.8 1.5 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG Pkinase PF00069.25 VDK86534.1 - 2.1e-49 168.3 0.1 7e-49 166.6 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86534.1 - 7e-31 107.4 0.0 1.2e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Polo_box_3 PF18544.1 VDK86534.1 - 2.9e-29 101.6 0.1 1.1e-28 99.8 0.1 2.1 1 0 0 1 1 1 1 Polo box domain Pkinase_fungal PF17667.1 VDK86534.1 - 6.8e-05 21.8 0.0 0.00012 21.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK86534.1 - 0.0003 20.2 0.1 0.00085 18.7 0.1 1.8 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Plk4_PB2 PF18409.1 VDK86534.1 - 0.019 15.7 0.7 0.14 12.9 0.0 2.7 3 1 0 3 3 3 0 Polo-like Kinase 4 Polo Box 2 Polo_box_2 PF18531.1 VDK86534.1 - 0.052 13.7 0.0 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 Polo box domain RIO1 PF01163.22 VDK86534.1 - 0.06 12.9 0.4 0.19 11.3 0.1 2.0 2 0 0 2 2 2 0 RIO1 family MBR1 PF17058.5 VDK86534.1 - 0.26 11.6 6.8 0.15 12.3 1.4 2.3 2 0 0 2 2 2 0 Mitochondrial biogenesis regulation protein 1 Neur_chan_LBD PF02931.23 VDK86536.1 - 1.5e-40 139.0 2.3 1.9e-40 138.7 2.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK86536.1 - 3.7e-20 73.0 3.2 2.7e-17 63.6 1.0 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region RIIa PF02197.17 VDK86537.1 - 6.4e-13 48.1 0.1 8.4e-13 47.8 0.1 1.2 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Telomere_reg-2 PF10193.9 VDK86537.1 - 0.0028 18.1 0.3 0.0033 17.9 0.3 1.0 1 0 0 1 1 1 1 Telomere length regulation protein Dpy-30 PF05186.13 VDK86537.1 - 0.0042 16.7 0.0 0.005 16.5 0.0 1.2 1 0 0 1 1 1 1 Dpy-30 motif DUF5586 PF17824.1 VDK86537.1 - 0.0083 15.3 0.0 0.0096 15.1 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5586) cNMP_binding PF00027.29 VDK86538.1 - 7.3e-39 131.7 0.0 2.3e-19 69.2 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 VDK86538.1 - 0.00064 19.4 0.3 0.012 15.3 0.0 2.2 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 VDK86538.1 - 0.24 11.1 0.8 23 4.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF861) fn3 PF00041.21 VDK86539.1 - 4.9e-06 26.8 0.0 1.3e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Fibronectin type III domain DUF805 PF05656.14 VDK86541.1 - 0.097 13.1 0.2 0.12 12.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF805) PDZ PF00595.24 VDK86543.1 - 1.4e-05 25.3 0.0 4.3e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK86543.1 - 0.0015 18.3 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PIF6 PF05341.11 VDK86543.1 - 0.006 16.7 0.3 0.062 13.4 0.0 2.3 2 0 0 2 2 2 1 Per os infectivity factor 6 Trs65 PF12735.7 VDK86543.1 - 0.14 11.6 2.8 0.23 10.9 2.8 1.2 1 0 0 1 1 1 0 TRAPP trafficking subunit Trs65 DUF647 PF04884.14 VDK86544.1 - 1.2e-88 296.8 1.8 1.6e-88 296.4 1.8 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis PDEase_I PF00233.19 VDK86545.1 - 6e-80 268.4 2.9 7.9e-80 268.0 2.9 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF2129 PF09902.9 VDK86545.1 - 0.0051 16.9 1.3 0.0091 16.0 0.9 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2129) ExsD PF16806.5 VDK86545.1 - 0.0071 16.3 0.8 0.011 15.6 0.4 1.5 1 1 0 1 1 1 1 Antiactivator protein ExsD rve_2 PF13333.6 VDK86545.1 - 0.037 14.2 0.2 0.12 12.5 0.0 1.9 2 0 0 2 2 2 0 Integrase core domain Ldl_recept_a PF00057.18 VDK86546.1 - 4.6e-06 26.8 7.1 0.0016 18.6 0.4 3.4 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A cEGF PF12662.7 VDK86546.1 - 0.22 11.5 6.9 0.8 9.7 0.5 3.0 2 0 0 2 2 2 0 Complement Clr-like EGF-like EGF_CA PF07645.15 VDK86546.1 - 4.2 7.7 9.4 0.31 11.3 2.4 2.7 2 0 0 2 2 2 0 Calcium-binding EGF domain Lectin_leg-like PF03388.13 VDK86547.1 - 5.1e-87 291.0 0.1 6.5e-87 290.7 0.1 1.1 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 VDK86547.1 - 5.8e-10 39.5 0.9 8.8e-10 38.9 0.9 1.2 1 0 0 1 1 1 1 Bacterial lectin zf-C2HC_2 PF13913.6 VDK86547.1 - 0.25 11.3 0.8 0.51 10.3 0.8 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type fn3 PF00041.21 VDK86548.1 - 7.9e-18 64.6 15.9 0.00074 19.8 0.1 6.3 5 1 1 6 6 6 5 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK86548.1 - 3e-08 34.1 0.9 0.074 13.6 0.1 4.2 3 1 0 3 3 3 3 Purple acid Phosphatase, N-terminal domain DUF2369 PF10179.9 VDK86548.1 - 0.0004 20.7 0.1 7.6 7.0 0.0 3.4 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) DEAD PF00270.29 VDK86550.1 - 4.4e-25 88.4 0.0 7.5e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK86550.1 - 7.7e-20 71.3 0.3 9e-19 67.9 0.1 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK86550.1 - 2.3e-07 31.0 0.0 7.9e-07 29.2 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 VDK86550.1 - 0.0014 18.9 0.7 0.0093 16.2 0.4 2.7 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 VDK86550.1 - 0.048 14.2 3.3 12 6.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain NOC3p PF07540.11 VDK86553.1 - 4e-23 81.7 0.4 4e-23 81.7 0.4 2.5 3 0 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.17 VDK86553.1 - 4.7e-13 49.5 2.8 1.3e-12 48.1 0.0 2.5 2 1 0 2 2 2 1 CBF/Mak21 family UCH PF00443.29 VDK86553.1 - 0.09 12.3 0.3 2.5 7.5 0.2 2.5 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Ground-like PF04155.18 VDK86554.1 - 2.1e-22 79.6 2.4 2.1e-22 79.6 2.4 2.0 1 1 2 3 3 3 1 Ground-like domain DEK_C PF08766.11 VDK86554.1 - 0.031 14.2 0.0 0.084 12.8 0.0 1.7 1 0 0 1 1 1 0 DEK C terminal domain DUF4921 PF16268.5 VDK86554.1 - 0.046 12.5 0.0 0.053 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4921) Hexapep PF00132.24 VDK86556.1 - 6.9e-09 35.1 21.0 2.6e-06 26.9 9.1 5.0 4 1 0 5 5 5 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 VDK86556.1 - 4.2e-05 23.2 5.9 4.2e-05 23.2 5.9 2.5 3 1 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Actin PF00022.19 VDK86558.1 - 4.2e-92 308.9 0.0 1.4e-90 303.9 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 VDK86558.1 - 0.00013 20.9 0.0 0.4 9.4 0.0 2.5 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 VDK86558.1 - 0.0056 17.1 0.0 0.023 15.1 0.0 2.0 2 1 0 2 2 2 1 Cell division protein FtsA NHL PF01436.21 VDK86559.1 - 2.3e-25 87.3 7.8 2.9e-06 27.0 0.2 5.3 5 0 0 5 5 5 4 NHL repeat SGL PF08450.12 VDK86559.1 - 0.00044 19.9 0.1 0.045 13.3 0.0 3.0 1 1 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 VDK86559.1 - 0.044 13.7 0.0 4.3 7.2 0.0 2.6 2 0 0 2 2 2 0 Esterase-like activity of phytase Laminin_G_2 PF02210.24 VDK86560.1 - 5.2e-25 88.4 0.0 3.8e-21 76.0 0.0 2.7 2 0 0 2 2 2 2 Laminin G domain Cadherin PF00028.17 VDK86560.1 - 6.8e-22 77.7 0.9 4.7e-14 52.6 0.2 5.0 5 0 0 5 5 5 3 Cadherin domain Cadherin_C PF01049.17 VDK86560.1 - 7.3e-22 78.3 0.1 1.7e-21 77.1 0.1 1.6 1 0 0 1 1 1 1 Cadherin cytoplasmic region Laminin_G_1 PF00054.23 VDK86560.1 - 2e-18 66.8 0.0 5.6e-18 65.4 0.0 1.8 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 VDK86560.1 - 1.7e-05 25.0 30.9 0.0075 16.6 3.2 4.4 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 VDK86560.1 - 0.00049 20.6 31.7 0.02 15.5 2.0 5.2 4 1 1 5 5 5 3 Human growth factor-like EGF Cadherin_3 PF16184.5 VDK86560.1 - 0.00069 19.6 0.9 3.6 7.6 0.1 3.6 3 0 0 3 3 3 1 Cadherin-like Cadherin_2 PF08266.12 VDK86560.1 - 0.17 11.7 0.0 0.8 9.6 0.0 2.0 2 0 0 2 2 2 0 Cadherin-like Pkinase PF00069.25 VDK86565.1 - 1e-53 182.4 0.0 3.7e-53 180.6 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86565.1 - 1.5e-26 93.3 0.0 3.2e-26 92.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 VDK86565.1 - 6.7e-12 45.1 4.7 1.4e-11 44.1 4.7 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) KELK PF15796.5 VDK86565.1 - 2e-10 40.9 17.2 2e-10 40.9 17.2 6.4 4 1 1 5 5 5 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase DMPK_coil PF08826.10 VDK86565.1 - 5.8e-08 32.7 15.3 5.8e-08 32.7 15.3 6.8 6 2 2 9 9 9 1 DMPK coiled coil domain like Kinase-like PF14531.6 VDK86565.1 - 1.5e-07 31.1 7.9 1.5e-05 24.5 0.0 2.5 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 VDK86565.1 - 2.7e-05 24.8 1.4 8.5e-05 23.2 1.4 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain PH PF00169.29 VDK86565.1 - 0.011 16.2 0.6 0.067 13.7 0.0 2.6 2 1 0 2 2 2 0 PH domain PHD PF00628.29 VDK86565.1 - 0.54 10.2 3.7 1.3 8.9 3.7 1.6 1 0 0 1 1 1 0 PHD-finger ArdA PF07275.11 VDK86565.1 - 1.3 9.6 12.2 0.41 11.2 7.1 2.9 2 1 0 2 2 2 0 Antirestriction protein (ArdA) DUF4948 PF16306.5 VDK86566.1 - 0.032 14.0 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4948) Cyt_b-c1_8 PF10890.8 VDK86566.1 - 0.078 13.4 0.2 0.18 12.2 0.2 1.6 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 ATP-synt_Z PF16594.5 VDK86566.1 - 0.092 12.2 0.0 0.092 12.2 0.0 2.6 3 0 0 3 3 3 0 Putative AtpZ or ATP-synthase-associated CNH PF00780.22 VDK86567.1 - 1.7e-45 155.8 0.0 2.7e-45 155.1 0.0 1.2 1 0 0 1 1 1 1 CNH domain PBD PF00786.28 VDK86567.1 - 0.11 12.8 0.1 0.3 11.5 0.1 1.7 1 0 0 1 1 1 0 P21-Rho-binding domain FdsD PF11390.8 VDK86568.1 - 0.038 14.3 0.0 0.064 13.6 0.0 1.4 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD APC_u15 PF16636.5 VDK86568.1 - 0.16 12.5 0.2 0.23 11.9 0.2 1.2 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr regions 5 and 6 zf-C4 PF00105.18 VDK86573.1 - 2.1e-14 53.7 4.5 4.4e-14 52.7 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK86573.1 - 1.2e-08 34.8 0.2 2.6e-08 33.7 0.2 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor SUIM_assoc PF16619.5 VDK86573.1 - 0.013 15.6 0.6 0.073 13.1 0.6 2.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 VDK86573.1 - 0.21 11.1 10.4 0.23 11.1 8.5 1.9 2 0 0 2 2 2 0 Spt20 family Miga PF10265.9 VDK86573.1 - 5.8 5.8 7.3 9.2 5.1 7.3 1.2 1 0 0 1 1 1 0 Mitoguardin TFIIA PF03153.13 VDK86573.1 - 6.8 6.6 9.9 10 6.0 9.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit F-box-like PF12937.7 VDK86576.1 - 1.6e-10 40.7 0.0 1.6e-10 40.7 0.0 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 VDK86576.1 - 7.3e-06 25.7 0.0 3e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 F-box domain WD40 PF00400.32 VDK86576.1 - 0.00019 22.2 5.9 1.2 10.1 0.1 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat Elongin_A PF06881.11 VDK86576.1 - 0.0067 16.9 0.2 0.016 15.7 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A PRANC PF09372.10 VDK86576.1 - 0.015 15.6 0.4 0.096 13.0 0.0 2.5 3 0 0 3 3 3 0 PRANC domain CTU2 PF10288.9 VDK86577.1 - 0.00014 22.1 0.2 0.00035 20.8 0.2 1.7 1 1 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 TMC PF07810.13 VDK86578.1 - 1.8e-23 83.2 3.0 6.3e-23 81.5 0.5 2.7 2 1 0 2 2 2 1 TMC domain Zip PF02535.22 VDK86585.1 - 6.7e-41 140.6 4.1 8.8e-41 140.2 4.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter HEAT PF02985.22 VDK86587.1 - 6.7e-14 50.8 1.1 0.046 14.0 0.0 6.6 7 0 0 7 7 7 3 HEAT repeat CLASP_N PF12348.8 VDK86587.1 - 5e-11 42.6 1.0 4.5e-05 23.1 0.1 2.9 2 1 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 VDK86587.1 - 1.4e-07 31.7 8.9 0.0039 17.3 0.6 4.7 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 VDK86587.1 - 2.5e-06 27.8 0.1 12 6.3 0.0 5.4 3 2 2 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 VDK86587.1 - 7.4e-05 23.2 0.1 0.24 11.9 0.0 4.4 4 1 1 5 5 5 1 HEAT-like repeat TAN PF11640.8 VDK86587.1 - 0.00022 21.4 1.7 0.075 13.2 0.2 3.0 2 1 0 2 2 2 2 Telomere-length maintenance and DNA damage repair Vac14_Fab1_bd PF12755.7 VDK86587.1 - 0.00063 20.3 0.2 0.66 10.6 0.1 3.9 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region HSR PF03172.13 VDK86587.1 - 0.0051 16.9 0.0 0.067 13.4 0.0 2.7 3 0 0 3 3 3 1 HSR domain MMS19_N PF14500.6 VDK86587.1 - 0.05 13.2 0.2 7 6.1 0.1 2.7 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II PigN PF04987.14 VDK86598.1 - 6.6e-72 242.8 51.9 8.4e-72 242.5 51.9 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 VDK86598.1 - 9.6e-14 51.7 1.3 1e-05 25.3 0.0 2.2 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 VDK86598.1 - 7.9e-10 38.6 0.0 1.1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 VDK86598.1 - 0.17 11.2 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily P16-Arc PF04699.14 VDK86599.1 - 1.4e-42 145.7 0.0 1.6e-42 145.5 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 VDK86599.1 - 0.00031 21.0 0.0 0.00057 20.2 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Kelch_5 PF13854.6 VDK86600.1 - 1.1e-30 105.1 0.3 0.00066 19.6 0.0 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 VDK86600.1 - 1.2e-26 92.4 0.5 1.9e-05 24.8 0.0 7.0 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 VDK86600.1 - 2.2e-26 91.6 0.0 2.8e-05 24.0 0.0 6.6 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 VDK86600.1 - 1.7e-23 82.1 1.3 0.0024 18.1 0.0 6.5 4 1 2 6 6 6 5 Kelch motif Kelch_1 PF01344.25 VDK86600.1 - 3.8e-20 71.2 1.8 2.8e-05 23.6 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 VDK86600.1 - 1.2e-15 56.7 0.3 0.074 13.1 0.0 6.8 6 0 0 6 6 6 4 Kelch motif fn3 PF00041.21 VDK86600.1 - 5.1e-08 33.1 0.0 0.053 13.9 0.0 4.2 4 0 0 4 4 4 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK86600.1 - 0.64 10.6 3.8 0.28 11.8 0.4 2.3 2 1 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain PGG PF13962.6 VDK86601.1 - 0.048 13.5 0.4 0.094 12.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function PrgH PF09480.10 VDK86601.1 - 0.11 11.8 0.0 0.39 10.0 0.0 1.7 1 1 1 2 2 2 0 Type III secretion system protein PrgH-EprH (PrgH) Vpu PF00558.19 VDK86601.1 - 0.12 12.1 0.1 0.12 12.1 0.1 1.5 2 0 0 2 2 2 0 Vpu protein Orf78 PF06024.12 VDK86601.1 - 0.14 12.4 0.3 1.4 9.3 0.0 2.0 2 0 0 2 2 2 0 Orf78 (ac78) DNApol_Exo PF18136.1 VDK86603.1 - 1.2e-53 182.1 0.7 2.6e-49 167.9 0.0 2.3 1 1 1 2 2 2 2 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 VDK86603.1 - 4.4e-07 29.3 0.0 6.2e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A TRAPP PF04051.16 VDK86604.1 - 2.4e-35 121.4 0.0 2.9e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Maelstrom PF13017.6 VDK86606.1 - 1.7e-05 24.6 3.6 9.7e-05 22.1 0.4 2.4 2 0 0 2 2 2 1 piRNA pathway germ-plasm component HMG_box_2 PF09011.10 VDK86606.1 - 0.017 15.7 0.5 0.078 13.6 0.5 2.2 1 0 0 1 1 1 0 HMG-box domain RNase_Zc3h12a PF11977.8 VDK86606.1 - 0.064 13.0 0.1 0.25 11.1 0.1 2.0 2 0 0 2 2 2 0 Zc3h12a-like Ribonuclease NYN domain Chromo PF00385.24 VDK86612.1 - 0.028 14.3 0.4 0.095 12.6 0.4 1.9 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain LAP1C PF05609.12 VDK86612.1 - 0.62 9.1 12.0 0.86 8.6 12.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Lustrin_cystein PF14625.6 VDK86613.1 - 0.00035 20.9 1.5 0.00059 20.2 1.5 1.4 1 0 0 1 1 1 1 Lustrin, cysteine-rich repeated domain Sec15 PF04091.12 VDK86614.1 - 3.7e-80 269.7 0.1 8.1e-80 268.6 0.1 1.6 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Vps51 PF08700.11 VDK86614.1 - 0.00074 19.6 0.6 0.3 11.2 0.2 3.0 2 0 0 2 2 2 2 Vps51/Vps67 Zw10 PF06248.13 VDK86614.1 - 0.0097 14.5 7.8 0.0072 15.0 5.6 1.9 2 1 0 2 2 2 1 Centromere/kinetochore Zw10 Sec8_exocyst PF04048.14 VDK86614.1 - 0.32 10.9 2.6 0.52 10.2 0.1 2.7 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain BLI1 PF17324.2 VDK86614.1 - 0.67 10.6 5.5 1.6 9.4 0.0 3.5 3 0 0 3 3 3 0 BLOC-1 interactor 1 Mito_carr PF00153.27 VDK86615.1 - 2.4e-66 219.7 0.7 4.7e-23 80.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 VDK86615.1 - 0.04 13.1 1.3 0.17 11.0 0.1 2.2 2 1 1 3 3 3 0 Gammaproteobacterial serine protease Haspin_kinase PF12330.8 VDK86616.1 - 1.6e-35 122.8 0.3 1.9e-35 122.5 0.3 1.0 1 0 0 1 1 1 1 Haspin like kinase domain MJ1316 PF04457.12 VDK86616.1 - 0.086 13.6 0.0 0.21 12.4 0.0 1.7 1 0 0 1 1 1 0 MJ1316 RNA cyclic group end recognition domain DUF865 PF05906.11 VDK86618.1 - 0.061 13.1 1.9 0.11 12.3 1.9 1.4 1 0 0 1 1 1 0 Herpesvirus-7 repeat of unknown function (DUF865) Rota_NSP4 PF01452.16 VDK86620.1 - 0.0096 15.6 0.0 0.011 15.4 0.0 1.0 1 0 0 1 1 1 1 Rotavirus non structural protein Peptidase_M24 PF00557.24 VDK86621.1 - 6.6e-21 75.0 0.0 9.5e-21 74.5 0.0 1.3 1 1 0 1 1 1 1 Metallopeptidase family M24 Glyco_hydro_47 PF01532.20 VDK86622.1 - 3.4e-104 349.3 0.0 6.8e-104 348.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Neur_chan_LBD PF02931.23 VDK86623.1 - 3.8e-13 49.4 2.7 6.5e-13 48.6 2.7 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Citrate_synt PF00285.21 VDK86625.1 - 6.2e-103 344.6 0.0 7.8e-103 344.3 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain MMS1_N PF10433.9 VDK86628.1 - 5e-161 536.7 0.0 3.1e-160 534.0 0.0 2.0 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 VDK86628.1 - 1.5e-22 80.4 0.0 6.4e-22 78.3 0.0 2.0 3 0 0 3 3 3 1 CPSF A subunit region PAN_1 PF00024.26 VDK86630.1 - 3.2e-18 65.4 16.0 4.4e-13 49.0 1.0 3.7 3 0 0 3 3 3 3 PAN domain EB PF01683.18 VDK86632.1 - 2.6e-27 94.9 94.3 6.7e-09 35.9 12.6 6.9 5 2 1 6 6 6 5 EB module Innexin PF00876.18 VDK86634.1 - 1.8e-109 366.3 11.6 2e-109 366.1 11.6 1.0 1 0 0 1 1 1 1 Innexin PP-binding PF00550.25 VDK86636.1 - 2.2e-13 50.4 0.2 3.6e-13 49.7 0.2 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 VDK86636.1 - 0.0087 16.3 0.5 0.012 15.8 0.5 1.4 1 1 0 1 1 1 1 Acyl-carrier HlyIII PF03006.20 VDK86637.1 - 3.7e-70 236.2 18.9 4.5e-70 235.9 18.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4405 PF14358.6 VDK86637.1 - 3.1 8.4 11.9 0.064 13.8 2.8 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) 7TM_GPCR_Srw PF10324.9 VDK86639.1 - 1.9e-36 126.0 25.4 8.5e-24 84.4 19.1 2.0 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 VDK86639.1 - 1.5e-07 31.0 14.7 3.3e-07 29.9 14.7 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK86639.1 - 0.00063 19.2 13.3 0.077 12.4 3.2 3.3 2 1 0 3 3 3 2 Serpentine type 7TM GPCR chemoreceptor Srsx Wzy_C PF04932.15 VDK86639.1 - 0.04 13.5 10.0 2 8.0 5.9 2.5 2 1 0 2 2 2 0 O-Antigen ligase Peptidase_M10 PF00413.24 VDK86640.1 - 2.1e-35 121.9 0.1 3.6e-35 121.2 0.1 1.3 1 0 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.6 VDK86640.1 - 0.014 15.1 0.1 0.027 14.1 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Comm PF15957.5 VDK86640.1 - 0.023 15.1 0.0 0.047 14.0 0.0 1.5 1 0 0 1 1 1 0 Commissureless Peptidase_M66 PF10462.9 VDK86640.1 - 0.03 13.3 0.2 0.052 12.5 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 Metallopep PF12044.8 VDK86640.1 - 0.037 12.6 0.1 0.077 11.6 0.1 1.4 1 0 0 1 1 1 0 Putative peptidase family Astacin PF01400.24 VDK86640.1 - 0.042 13.4 0.0 1.1 8.9 0.0 2.7 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) Reprolysin_3 PF13582.6 VDK86640.1 - 0.065 13.8 0.2 0.17 12.4 0.2 1.8 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 VDK86640.1 - 0.069 13.1 0.4 0.26 11.2 0.1 2.0 2 1 1 3 3 3 0 Peptidase family M54 SCIMP PF15050.6 VDK86640.1 - 0.1 13.0 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 SCIMP protein IQCJ-SCHIP1 PF15157.6 VDK86640.1 - 0.17 11.7 1.7 1.2 9.0 0.0 2.2 2 0 0 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif mRNA_cap_enzyme PF01331.19 VDK86642.1 - 1.7e-68 230.3 0.2 2.6e-68 229.7 0.2 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 VDK86642.1 - 3.8e-18 66.1 0.0 8e-18 65.1 0.0 1.6 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DSPc PF00782.20 VDK86642.1 - 1.5e-11 44.2 0.0 3.8e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DNA_ligase_A_M PF01068.21 VDK86642.1 - 8.4e-08 32.1 0.0 6.8e-06 25.9 0.0 2.4 1 1 0 1 1 1 1 ATP dependent DNA ligase domain Y_phosphatase3 PF13350.6 VDK86642.1 - 0.00043 20.3 0.0 0.00077 19.5 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 VDK86642.1 - 0.017 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 VDK86642.1 - 0.019 15.1 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate SET PF00856.28 VDK86651.1 - 3.7e-09 37.2 4.7 3.9e-09 37.1 0.0 2.9 2 2 0 2 2 2 1 SET domain Rsc14 PF08586.10 VDK86651.1 - 2 9.3 4.3 9.1 7.2 0.2 3.2 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit Phosphodiest PF01663.22 VDK86654.1 - 2.5e-42 145.8 0.2 2.9e-42 145.6 0.2 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase MutL_C PF08676.11 VDK86661.1 - 0.17 11.6 4.5 0.26 11.1 4.5 1.3 1 0 0 1 1 1 0 MutL C terminal dimerisation domain Spt20 PF12090.8 VDK86661.1 - 2.2 7.8 10.9 3 7.4 10.9 1.2 1 0 0 1 1 1 0 Spt20 family cNMP_binding PF00027.29 VDK86662.1 - 6.8e-19 67.7 0.0 1.2e-18 66.9 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 VDK86662.1 - 6.6e-13 48.5 15.4 9.6e-12 44.6 15.4 2.1 1 1 0 1 1 1 1 Ion transport protein HTH_23 PF13384.6 VDK86662.1 - 0.045 13.6 0.3 0.15 11.9 0.3 1.9 1 0 0 1 1 1 0 Homeodomain-like domain Ion_trans_2 PF07885.16 VDK86662.1 - 3.3 7.7 8.6 0.093 12.7 1.8 2.0 2 1 0 2 2 2 0 Ion channel PB1 PF00564.24 VDK86663.1 - 1.3e-14 53.9 1.1 2.3e-14 53.1 1.1 1.4 1 0 0 1 1 1 1 PB1 domain SL4P PF17618.2 VDK86663.1 - 0.066 13.3 0.4 0.13 12.3 0.4 1.5 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein NTP_transferase PF00483.23 VDK86664.1 - 1.5e-21 77.1 0.0 4.4e-21 75.6 0.0 1.6 1 1 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 VDK86664.1 - 1.1e-08 34.4 5.2 1.8e-05 24.2 0.1 3.6 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 VDK86664.1 - 3.3e-05 24.3 0.0 5.8e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 VDK86664.1 - 0.073 12.8 0.1 1 9.1 0.0 2.6 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Ion_trans_2 PF07885.16 VDK86668.1 - 1.2e-36 124.5 23.5 2.4e-18 65.8 12.3 3.2 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDK86668.1 - 4.7e-10 39.1 15.4 4.7e-05 22.7 1.1 2.2 2 0 0 2 2 2 2 Ion transport protein Adap_comp_sub PF00928.21 VDK86669.1 - 2.2e-80 269.9 0.0 2.8e-80 269.5 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 VDK86669.1 - 1.3e-07 31.7 0.5 2.3e-07 30.9 0.5 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Homeodomain PF00046.29 VDK86670.1 - 8.7e-19 67.1 5.8 1.4e-18 66.4 5.8 1.4 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 VDK86670.1 - 0.03 13.8 0.2 0.062 12.8 0.2 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez Homeobox_KN PF05920.11 VDK86670.1 - 0.061 13.2 0.3 0.16 11.9 0.3 1.7 1 0 0 1 1 1 0 Homeobox KN domain Homeodomain PF00046.29 VDK86671.1 - 2.1e-22 78.7 2.5 1.3e-21 76.2 1.7 2.3 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 VDK86671.1 - 0.00013 21.8 0.1 0.0017 18.3 0.0 2.4 2 0 0 2 2 2 1 Homeobox KN domain Homez PF11569.8 VDK86671.1 - 0.098 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez La PF05383.17 VDK86672.1 - 6.3e-21 74.2 0.3 1.3e-20 73.2 0.3 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 VDK86672.1 - 0.056 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HMG_box PF00505.19 VDK86673.1 - 4.6e-16 59.0 6.4 9.4e-16 58.0 6.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK86673.1 - 6.2e-09 36.3 4.4 2e-08 34.7 4.4 1.9 1 0 0 1 1 1 1 HMG-box domain Nucleo_P87 PF07267.11 VDK86673.1 - 7.8 5.2 10.2 10 4.8 10.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CssAB PF16831.5 VDK86674.1 - 0.064 13.6 0.8 0.089 13.2 0.6 1.3 1 1 0 1 1 1 0 CS6 fimbrial subunits A and B, Coli surface antigen 6 Cas_APE2256 PF09651.10 VDK86674.1 - 0.072 13.0 0.0 0.095 12.6 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) MIF4G_like_2 PF09090.11 VDK86679.1 - 2.1e-55 188.1 5.9 2.1e-55 188.1 5.9 2.6 3 0 0 3 3 3 1 MIF4G like MIF4G_like PF09088.11 VDK86679.1 - 1.6e-33 116.1 1.2 1.6e-33 116.1 1.2 3.1 4 1 1 5 5 5 1 MIF4G like MIF4G PF02854.19 VDK86679.1 - 8.5e-22 77.8 2.5 8.5e-22 77.8 2.5 2.1 2 0 0 2 2 2 1 MIF4G domain PEPcase PF00311.17 VDK86679.1 - 0.016 13.3 0.4 0.026 12.6 0.4 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Bac_RepA_C PF18008.1 VDK86679.1 - 0.082 13.3 0.2 22 5.5 0.0 3.2 3 0 0 3 3 3 0 Replication initiator protein A C-terminal domain Endonuc-MspI PF09208.10 VDK86679.1 - 0.16 11.3 1.5 0.39 10.1 0.0 2.2 3 0 0 3 3 3 0 Restriction endonuclease MspI 3HCDH_N PF02737.18 VDK86680.1 - 3.1e-56 190.1 3.1 4e-56 189.8 3.1 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 VDK86680.1 - 1.2e-34 118.8 0.0 2.9e-34 117.6 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Pyr_redox_2 PF07992.14 VDK86680.1 - 1.5e-05 24.4 0.4 2.1e-05 23.9 0.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 VDK86680.1 - 0.00051 19.7 1.4 0.0013 18.3 1.4 1.7 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 VDK86680.1 - 0.00072 19.8 2.6 0.0018 18.5 2.6 1.6 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 VDK86680.1 - 0.001 18.8 0.0 0.0012 18.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 VDK86680.1 - 0.0013 19.2 0.3 0.0025 18.3 0.3 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 VDK86680.1 - 0.0018 17.6 1.5 0.0018 17.6 1.5 1.6 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.23 VDK86680.1 - 0.011 15.8 1.1 0.021 14.8 1.1 1.5 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Methyltransf_31 PF13847.6 VDK86680.1 - 0.018 14.9 0.2 0.031 14.1 0.2 1.4 1 0 0 1 1 1 0 Methyltransferase domain DFP PF04127.15 VDK86680.1 - 0.051 13.4 2.3 0.15 11.9 2.1 1.8 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_7 PF13241.6 VDK86680.1 - 0.064 13.7 0.5 0.11 12.9 0.5 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_8 PF13450.6 VDK86680.1 - 0.069 13.4 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ApbA PF02558.16 VDK86680.1 - 0.15 11.7 0.9 0.23 11.1 0.9 1.4 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 VDK86680.1 - 0.22 11.8 2.7 0.5 10.6 2.7 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HECT PF00632.25 VDK86681.1 - 6.2e-78 262.4 0.9 9.4e-78 261.8 0.9 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.18 VDK86681.1 - 1.7e-65 217.5 21.0 2.4e-12 47.3 0.0 8.2 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 VDK86681.1 - 5.5e-54 179.0 30.5 2.7e-11 43.0 0.6 7.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.14 VDK86681.1 - 0.35 10.8 3.0 6.8 6.6 0.0 3.8 4 1 0 4 4 4 0 Peptidase family C25, C terminal ig-like domain Ank_2 PF12796.7 VDK86686.1 - 1.4e-18 67.2 1.0 4.9e-12 46.3 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 VDK86686.1 - 1.8e-14 53.4 2.1 6.4e-06 26.4 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 VDK86686.1 - 2e-11 44.2 3.3 2.9e-08 34.1 0.1 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK86686.1 - 5.6e-11 42.5 1.2 2.3e-08 34.2 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK86686.1 - 4.9e-07 29.6 0.2 0.012 16.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Sulfate_transp PF00916.20 VDK86687.1 - 6.3e-93 311.6 23.5 1.5e-50 172.1 6.6 2.2 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 VDK86687.1 - 0.00031 20.3 0.0 0.0006 19.4 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 VDK86687.1 - 0.0072 16.7 7.0 0.0072 16.7 7.0 2.8 2 1 0 2 2 2 1 Molybdate transporter of MFS superfamily Tissue_fac PF01108.17 VDK86687.1 - 0.15 11.9 0.2 0.36 10.7 0.2 1.6 1 0 0 1 1 1 0 Tissue factor bZIP_1 PF00170.21 VDK86689.1 - 4e-08 33.2 9.7 7.4e-08 32.4 9.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 VDK86689.1 - 2.7e-06 27.3 10.9 4.8e-06 26.6 10.9 1.4 1 0 0 1 1 1 1 Basic region leucine zipper Pox_A30L_A26L PF06086.12 VDK86689.1 - 0.021 14.5 0.2 0.047 13.4 0.2 1.5 1 0 0 1 1 1 0 Orthopoxvirus A26L/A30L protein DivIC PF04977.15 VDK86689.1 - 0.034 13.9 0.8 0.068 12.9 0.8 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_Maf PF03131.17 VDK86689.1 - 0.048 14.2 3.5 0.11 13.0 3.5 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor KLRAQ PF10205.9 VDK86689.1 - 0.15 12.4 2.4 0.33 11.2 2.4 1.6 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein ABC_membrane_2 PF06472.15 VDK86690.1 - 3.9e-54 183.9 7.8 6e-54 183.3 7.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 VDK86690.1 - 4.4e-13 49.9 0.0 8.2e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ICE2 PF08426.10 VDK86690.1 - 0.0018 17.5 2.3 0.0029 16.8 2.3 1.4 1 0 0 1 1 1 1 ICE2 AAA_16 PF13191.6 VDK86690.1 - 0.019 15.4 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain F-box-like PF12937.7 VDK86691.1 - 1.7e-06 27.8 0.3 4.1e-06 26.6 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 VDK86691.1 - 4.6e-06 26.4 1.1 1.6e-05 24.7 0.1 2.4 2 0 0 2 2 2 1 F-box domain Methyltransf_17 PF12692.7 VDK86691.1 - 0.045 13.8 0.0 0.29 11.1 0.0 2.0 2 0 0 2 2 2 0 S-adenosyl-L-methionine methyltransferase F-box-like_2 PF13013.6 VDK86691.1 - 0.077 13.0 0.1 0.36 10.8 0.0 2.1 2 0 0 2 2 2 0 F-box-like domain LRR_4 PF12799.7 VDK86691.1 - 0.59 10.6 21.3 23 5.6 5.6 6.5 3 2 3 6 6 6 0 Leucine Rich repeats (2 copies) zf-H2C2_2 PF13465.6 VDK86692.1 - 2.8e-05 24.3 14.5 8.2e-05 22.9 6.5 9.2 9 1 1 10 10 10 3 Zinc-finger double domain zf-C2H2 PF00096.26 VDK86692.1 - 6.1e-05 23.3 90.8 0.013 15.9 4.8 9.2 9 0 0 9 9 9 6 Zinc finger, C2H2 type Actin_micro PF17003.5 VDK86692.1 - 0.072 12.3 11.7 0.39 9.9 0.1 3.0 2 0 0 2 2 2 0 Putative actin-like family DUF2459 PF09601.10 VDK86692.1 - 3.5 7.4 5.7 8.4 6.2 5.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2459) Phosphodiest PF01663.22 VDK86694.1 - 2.6e-12 47.0 1.5 4.6e-09 36.3 0.3 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 VDK86694.1 - 1.2e-07 31.4 0.1 0.00011 21.8 0.0 2.2 1 1 1 2 2 2 2 Sulfatase Metalloenzyme PF01676.18 VDK86694.1 - 0.0032 16.9 0.0 0.0053 16.2 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Gal-bind_lectin PF00337.22 VDK86695.1 - 4.4e-71 236.7 0.0 8e-35 119.3 0.0 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin Pro_isomerase PF00160.21 VDK86696.1 - 7.9e-51 172.5 0.1 8.8e-51 172.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DSL PF01414.19 VDK86703.1 - 0.027 14.7 1.6 0.027 14.7 1.6 2.3 2 0 0 2 2 2 0 Delta serrate ligand MRAP PF15183.6 VDK86703.1 - 0.15 12.0 0.2 0.35 10.8 0.2 1.6 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Collectrin PF16959.5 VDK86703.1 - 0.92 9.3 3.0 0.82 9.4 1.1 1.8 2 0 0 2 2 2 0 Renal amino acid transporter SIR2 PF02146.17 VDK86704.1 - 1.8e-23 83.4 0.3 4e-17 62.7 0.0 2.5 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 VDK86704.1 - 0.034 13.9 0.0 4.6 7.0 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Caprin-1_dimer PF18293.1 VDK86705.1 - 1.6e-08 35.1 0.4 3.3e-08 34.0 0.4 1.6 1 0 0 1 1 1 1 Caprin-1 dimerization domain MAGUK_N_PEST PF10608.9 VDK86706.1 - 1.5 9.2 6.5 1.8 9.0 0.3 2.5 2 0 0 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK VWA_N2 PF16164.5 VDK86706.1 - 2.6 8.3 7.8 7.2 6.8 0.3 2.7 2 0 0 2 2 2 0 VWA N-terminal MFS_2 PF13347.6 VDK86711.1 - 2.4e-13 49.5 9.6 2.9e-13 49.2 9.6 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein MH2 PF03166.14 VDK86713.1 - 6e-71 238.5 0.1 8.7e-71 238.0 0.1 1.2 1 0 0 1 1 1 1 MH2 domain MH1 PF03165.16 VDK86713.1 - 3.9e-36 123.4 2.9 8.2e-36 122.3 2.9 1.6 1 0 0 1 1 1 1 MH1 domain IRF-3 PF10401.9 VDK86713.1 - 0.057 13.2 0.0 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Interferon-regulatory factor 3 Peptidase_M14 PF00246.24 VDK86718.1 - 7.9e-63 213.0 0.1 8.7e-63 212.8 0.1 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase RsfS PF02410.15 VDK86722.1 - 1.4e-18 67.2 0.0 2.2e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Pro_isomerase PF00160.21 VDK86724.1 - 1.2e-47 162.1 0.0 1.4e-47 161.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DSPc PF00782.20 VDK86725.1 - 1.1e-30 106.1 0.0 1.5e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK86725.1 - 0.0041 16.7 0.0 0.0059 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Cg6151-P PF10233.9 VDK86725.1 - 0.061 13.6 0.0 0.092 13.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein CG6151-P BTB PF00651.31 VDK86727.1 - 0.0019 18.4 0.3 0.0028 17.8 0.3 1.2 1 0 0 1 1 1 1 BTB/POZ domain Arc_PepC PF06819.11 VDK86727.1 - 0.079 13.1 0.1 0.16 12.1 0.1 1.5 1 1 1 2 2 2 0 Archaeal Peptidase A24 C-terminal Domain Amdo_NSP PF12475.8 VDK86727.1 - 5.8 7.1 8.3 42 4.3 0.9 2.7 1 1 1 2 2 2 0 Amdovirus non-structural protein BACK PF07707.15 VDK86728.1 - 4.9e-05 23.4 0.0 9.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch zf-TRAF_2 PF15965.5 VDK86729.1 - 6.2e-23 81.1 27.0 6.2e-23 81.1 27.0 3.5 3 2 1 4 4 4 1 TRAF-like zinc-finger F-box_4 PF15966.5 VDK86729.1 - 2.3e-21 75.8 5.3 6.6e-21 74.3 1.7 2.8 2 0 0 2 2 2 1 F-box F-box PF00646.33 VDK86729.1 - 2.2e-05 24.2 2.1 7.1e-05 22.6 2.1 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 VDK86729.1 - 0.0011 18.8 0.4 0.0027 17.6 0.4 1.6 1 0 0 1 1 1 1 F-box-like CSN8_PSD8_EIF3K PF10075.9 VDK86731.1 - 1.4e-15 57.5 0.0 4.8e-14 52.5 0.0 2.2 1 1 0 1 1 1 1 CSN8/PSMD8/EIF3K family Epimerase PF01370.21 VDK86733.1 - 4.6e-22 78.7 0.0 5.9e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 VDK86733.1 - 3.2e-16 59.7 0.0 1.5e-14 54.2 0.0 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 VDK86733.1 - 1.4e-11 44.1 0.0 2.1e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 VDK86733.1 - 3.2e-06 26.5 0.0 3.2e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 VDK86733.1 - 5.6e-06 25.6 0.0 2.8e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 VDK86733.1 - 0.00011 21.5 0.4 0.0023 17.1 0.4 2.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF21 PF01595.20 VDK86735.1 - 3.7e-20 72.3 6.5 1.3e-19 70.6 6.5 1.8 1 1 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 VDK86735.1 - 1.2e-05 25.7 0.0 0.12 12.8 0.0 3.0 2 0 0 2 2 2 2 CBS domain Telomerase_RBD PF12009.8 VDK86735.1 - 0.039 14.1 0.1 0.039 14.1 0.1 3.2 4 0 0 4 4 4 0 Telomerase ribonucleoprotein complex - RNA binding domain ER_lumen_recept PF00810.18 VDK86736.1 - 3.2e-56 190.3 11.1 8.5e-56 188.9 11.1 1.7 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 VDK86736.1 - 0.19 11.5 5.1 0.45 10.3 0.3 3.1 2 1 0 2 2 2 0 PQ loop repeat Citrate_bind PF16114.5 VDK86738.1 - 5.3e-87 289.9 0.1 8.8e-87 289.2 0.1 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 VDK86738.1 - 2e-21 76.5 0.0 2.1e-20 73.1 0.0 2.3 1 1 0 1 1 1 1 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 VDK86738.1 - 6.6e-17 61.7 0.0 1.4e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 VDK86738.1 - 3.6e-13 50.0 0.0 7.5e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.10 VDK86738.1 - 3.4e-06 26.8 0.0 6e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Peripla_BP_4 PF13407.6 VDK86738.1 - 0.18 11.4 0.0 0.49 9.9 0.0 1.7 1 0 0 1 1 1 0 Periplasmic binding protein domain GNT-I PF03071.15 VDK86740.1 - 5.1e-150 500.0 0.6 5.9e-150 499.8 0.6 1.0 1 0 0 1 1 1 1 GNT-I family zf-C4 PF00105.18 VDK86744.1 - 9.7e-31 106.0 14.4 1.7e-30 105.2 14.4 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) zf-H2C2_2 PF13465.6 VDK86745.1 - 2.3e-21 75.2 41.2 3.6e-06 27.2 5.0 6.3 6 0 0 6 6 6 5 Zinc-finger double domain zf-C2H2 PF00096.26 VDK86745.1 - 4.3e-21 74.1 44.3 1.9e-05 24.8 4.8 5.4 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK86745.1 - 2.1e-17 62.3 40.4 0.0048 17.6 6.6 5.6 5 0 0 5 5 5 5 C2H2-type zinc finger zf-C2H2_6 PF13912.6 VDK86745.1 - 3.1e-07 30.2 37.6 0.03 14.3 2.4 5.4 5 0 0 5 5 5 4 C2H2-type zinc finger Zn_ribbon_SprT PF17283.2 VDK86745.1 - 0.0001 22.1 0.8 0.0001 22.1 0.8 3.6 2 1 1 3 3 3 2 SprT-like zinc ribbon domain Zn-ribbon_8 PF09723.10 VDK86745.1 - 0.0002 21.4 19.7 0.59 10.3 0.1 4.5 3 1 2 5 5 5 3 Zinc ribbon domain zf-C2H2_11 PF16622.5 VDK86745.1 - 0.0015 18.2 23.0 0.15 11.8 0.0 4.8 5 0 0 5 5 5 3 zinc-finger C2H2-type zf-C2H2_7 PF15269.6 VDK86745.1 - 0.031 14.4 1.2 0.031 14.4 1.2 3.1 3 0 0 3 3 3 0 Zinc-finger zf-C2HE PF16278.5 VDK86745.1 - 0.048 14.1 3.6 0.048 14.1 3.6 4.5 1 1 3 4 4 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 VDK86745.1 - 0.069 13.6 1.5 0.069 13.6 1.5 4.7 4 0 0 4 4 3 0 Zinc-finger of C2H2 type zinc_ribbon_15 PF17032.5 VDK86745.1 - 0.14 13.0 19.4 0.11 13.3 4.5 3.4 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_jaz PF12171.8 VDK86745.1 - 0.3 11.4 31.4 0.11 12.8 2.2 4.7 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.6 VDK86745.1 - 0.34 10.9 14.7 1.3 9.1 0.6 4.0 1 1 1 3 3 3 0 CpXC protein BolA PF01722.18 VDK86745.1 - 0.36 11.2 4.1 4 7.8 0.7 3.1 1 1 1 2 2 2 0 BolA-like protein zf-C2H2_2 PF12756.7 VDK86745.1 - 0.93 9.9 29.2 7.6 6.9 5.0 4.1 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zinc-ribbons_6 PF07191.12 VDK86745.1 - 4 7.5 20.9 6.1e+02 0.5 10.5 4.6 1 1 1 2 2 2 0 zinc-ribbons LIM PF00412.22 VDK86745.1 - 8.7 6.7 24.8 3.3 8.0 3.9 4.1 1 1 3 4 4 4 0 LIM domain HEAT PF02985.22 VDK86746.1 - 4.9e-15 54.3 17.8 0.001 19.2 0.1 10.1 12 0 0 12 12 12 3 HEAT repeat HEAT_EZ PF13513.6 VDK86746.1 - 1.2e-14 54.4 7.8 9.3e-06 26.0 0.0 6.6 7 0 0 7 7 7 4 HEAT-like repeat IBN_N PF03810.19 VDK86746.1 - 2e-11 43.7 0.7 9.6e-09 35.0 0.0 4.6 5 0 0 5 5 5 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 VDK86746.1 - 1.9e-08 34.6 1.2 0.52 10.7 0.2 6.8 5 2 2 7 7 7 2 HEAT repeats Cnd1 PF12717.7 VDK86746.1 - 2.4e-07 30.9 3.8 0.0021 18.1 0.0 4.5 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.7 VDK86746.1 - 0.012 14.8 2.5 0.063 12.5 0.7 3.0 3 1 0 3 3 3 0 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 VDK86746.1 - 0.026 14.1 0.0 48 3.4 0.0 4.4 2 2 1 3 3 3 0 CLASP N terminal HEAT_PBS PF03130.16 VDK86746.1 - 0.064 13.9 1.3 43 5.2 0.0 5.3 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat TAF6_C PF07571.13 VDK86746.1 - 0.16 12.3 0.7 4.9 7.5 0.0 3.7 4 1 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain Arm PF00514.23 VDK86746.1 - 0.66 10.1 8.0 1.8 8.8 0.3 4.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat UFD1 PF03152.14 VDK86747.1 - 2.2e-72 242.1 0.0 2.9e-72 241.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 VDK86747.1 - 0.005 16.6 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 SNF2_N PF00176.23 VDK86751.1 - 2.1e-35 122.1 2.8 1.1e-18 67.1 0.5 2.5 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK86751.1 - 1.9e-17 63.6 0.2 1.7e-16 60.6 0.0 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 VDK86751.1 - 1.4e-11 44.1 0.0 1.4e-11 44.1 0.0 3.3 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 VDK86751.1 - 0.0004 20.4 0.0 0.0004 20.4 0.0 2.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 VDK86751.1 - 0.0051 16.1 0.1 0.0051 16.1 0.1 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase hGDE_central PF14702.6 VDK86751.1 - 0.045 13.4 2.3 0.13 11.9 2.3 1.7 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme YEATS PF03366.16 VDK86752.1 - 1.1e-22 79.8 0.1 2.3e-22 78.7 0.1 1.6 1 0 0 1 1 1 1 YEATS family AHD PF17793.1 VDK86752.1 - 3.6e-05 23.5 2.3 0.00065 19.5 2.3 2.6 1 1 0 1 1 1 1 ANC1 homology domain (AHD) YonK PF09642.10 VDK86752.1 - 0.044 13.9 0.2 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 YonK protein VAPB_antitox PF02697.14 VDK86752.1 - 0.43 11.4 4.2 0.87 10.4 4.2 1.5 1 0 0 1 1 1 0 Putative antitoxin Ank_2 PF12796.7 VDK86753.1 - 9.4e-59 196.0 24.6 1e-14 54.9 0.6 6.4 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDK86753.1 - 1.2e-47 154.3 16.1 2.5e-05 24.3 0.0 12.9 13 0 0 13 13 13 11 Ankyrin repeat Ank_4 PF13637.6 VDK86753.1 - 1.8e-46 155.9 14.3 2.3e-10 40.8 0.4 9.3 5 3 3 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK86753.1 - 4.3e-46 154.4 10.2 5.8e-10 39.2 0.2 9.5 4 1 6 10 10 10 8 Ankyrin repeats (many copies) Ank PF00023.30 VDK86753.1 - 4.9e-37 124.8 22.2 1.4e-05 25.3 0.0 12.0 12 0 0 12 12 12 9 Ankyrin repeat DUF2520 PF10728.9 VDK86753.1 - 0.38 10.5 3.1 11 5.8 0.1 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF2520) UDG PF03167.19 VDK86759.1 - 2.2e-23 82.9 0.0 3.4e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily TrkH PF02386.16 VDK86762.1 - 1.3 7.3 4.1 2.1 6.7 4.1 1.2 1 0 0 1 1 1 0 Cation transport protein RNA_pol_Rpb2_6 PF00562.28 VDK86764.1 - 9e-129 429.9 0.6 1.3e-128 429.4 0.6 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 VDK86764.1 - 4e-69 232.2 0.0 6.2e-69 231.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 VDK86764.1 - 8.3e-54 182.1 0.0 4.2e-53 179.8 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 VDK86764.1 - 1.2e-32 112.1 0.9 2.5e-32 111.1 0.0 2.1 3 0 0 3 3 3 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 VDK86764.1 - 5.8e-25 87.3 0.0 1.3e-24 86.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 VDK86764.1 - 9.4e-23 80.3 0.4 2.1e-22 79.2 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 VDK86764.1 - 2.6e-16 59.9 0.3 6.5e-16 58.6 0.3 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 OrfB_Zn_ribbon PF07282.11 VDK86764.1 - 0.19 11.7 1.5 1.5 8.8 0.4 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain C1_2 PF03107.16 VDK86764.1 - 1.1 9.7 4.2 7.5 7.0 3.8 2.4 1 1 1 2 2 2 0 C1 domain Pkinase PF00069.25 VDK86766.1 - 1.7e-25 89.9 0.0 2e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86766.1 - 2.8e-12 46.5 0.0 3.8e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK86766.1 - 8.6e-05 21.5 0.0 0.00012 21.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Phage_P2_GpU PF06995.11 VDK86769.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Phage P2 GpU Collagen PF01391.18 VDK86770.1 - 1.4e-25 88.8 113.4 1.9e-10 40.3 41.8 3.9 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK86770.1 - 6.4e-21 74.2 0.2 8e-21 73.8 0.2 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Peptidase_M1 PF01433.20 VDK86776.1 - 0.0059 16.2 0.9 0.0087 15.6 0.9 1.4 1 1 0 1 1 1 1 Peptidase family M1 domain DUF4508 PF14969.6 VDK86776.1 - 0.0073 16.5 0.8 0.02 15.1 0.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) SYF2 PF08231.12 VDK86776.1 - 0.013 16.0 5.3 0.18 12.2 1.3 2.2 2 0 0 2 2 2 0 SYF2 splicing factor DUF3437 PF11919.8 VDK86776.1 - 0.054 13.4 4.3 6.7 6.7 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3437) LMBR1 PF04791.16 VDK86776.1 - 0.068 12.1 3.2 0.079 11.8 3.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein GIDA_assoc PF13932.6 VDK86776.1 - 0.086 13.0 4.7 0.15 12.3 4.7 1.3 1 0 0 1 1 1 0 GidA associated domain XLF PF09302.11 VDK86776.1 - 0.094 12.9 3.7 0.082 13.1 1.2 1.9 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component MRC1 PF09444.10 VDK86776.1 - 0.18 12.3 4.7 1.4 9.4 0.6 2.1 1 1 1 2 2 2 0 MRC1-like domain Uso1_p115_C PF04871.13 VDK86776.1 - 1.3 9.4 9.4 0.81 10.1 2.7 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Plk4_PB2 PF18409.1 VDK86776.1 - 1.4 9.6 5.0 12 6.6 1.1 3.0 1 1 2 3 3 3 0 Polo-like Kinase 4 Polo Box 2 Romo1 PF10247.9 VDK86777.1 - 1.4e-20 73.4 16.5 2.2e-20 72.7 16.5 1.3 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 VDK86777.1 - 0.00037 20.9 7.8 0.00048 20.5 7.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Bacteriocin_IIc PF10439.9 VDK86777.1 - 0.0029 17.7 1.1 0.006 16.7 1.1 1.5 1 0 0 1 1 1 1 Bacteriocin class II with double-glycine leader peptide Rotamase PF00639.21 VDK86778.1 - 7.3e-22 78.1 0.4 1.2e-21 77.4 0.0 1.5 2 0 0 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 VDK86778.1 - 4e-17 62.8 0.0 6.9e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 VDK86778.1 - 7.1e-12 45.2 0.6 1.4e-11 44.2 0.6 1.5 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 VDK86778.1 - 1.8e-05 25.6 0.0 3.8e-05 24.5 0.0 1.6 2 0 0 2 2 2 1 PPIC-type PPIASE domain Glyco_hyd_101C PF17451.2 VDK86778.1 - 0.064 13.6 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain EntA_Immun PF08951.10 VDK86778.1 - 0.079 13.3 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Enterocin A Immunity PQQ PF01011.21 VDK86778.1 - 0.095 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 PQQ enzyme repeat DUF4337 PF14235.6 VDK86778.1 - 0.83 9.7 2.2 22 5.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) DAO PF01266.24 VDK86779.1 - 7.3e-49 167.2 0.0 9.3e-49 166.9 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 VDK86779.1 - 9.4e-05 22.6 0.0 0.0013 18.9 0.0 2.8 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain Sacchrp_dh_NADP PF03435.18 VDK86779.1 - 0.0007 19.9 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 VDK86779.1 - 0.0025 17.1 0.0 0.01 15.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 VDK86779.1 - 0.0028 18.2 0.0 0.0061 17.1 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 VDK86779.1 - 0.038 14.2 0.1 0.17 12.2 0.0 2.1 3 0 0 3 3 3 0 TrkA-N domain GMC_oxred_N PF00732.19 VDK86779.1 - 0.043 13.2 0.0 5.4 6.3 0.0 2.3 2 0 0 2 2 2 0 GMC oxidoreductase Trp_halogenase PF04820.14 VDK86779.1 - 0.11 11.3 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Chromo PF00385.24 VDK86780.1 - 3.6e-12 46.0 0.3 1.3e-11 44.2 0.3 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Ion_trans_2 PF07885.16 VDK86782.1 - 8.8e-32 108.9 19.2 1.9e-17 63.0 4.5 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 VDK86782.1 - 1.1e-05 24.8 10.2 0.0038 16.5 1.0 2.3 2 0 0 2 2 2 2 Ion transport protein Flavodoxin_4 PF12682.7 VDK86782.1 - 0.031 14.0 0.1 0.048 13.4 0.1 1.4 1 0 0 1 1 1 0 Flavodoxin Pyr_redox_2 PF07992.14 VDK86783.1 - 1.5e-64 218.1 5.4 1.9e-64 217.7 5.4 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 VDK86783.1 - 4.8e-42 142.7 0.1 3.3e-41 140.0 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 VDK86783.1 - 5.5e-17 62.1 9.9 2.4e-14 53.6 2.9 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 VDK86783.1 - 3.9e-12 46.3 8.7 1.1e-09 38.2 0.0 3.0 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 VDK86783.1 - 1.2e-09 37.9 4.0 4.4e-09 36.0 4.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 VDK86783.1 - 3.6e-08 32.9 6.5 1.7e-07 30.7 0.4 3.5 2 1 2 4 4 4 1 FAD binding domain NAD_binding_8 PF13450.6 VDK86783.1 - 8e-08 32.4 1.7 5.8e-05 23.2 0.1 2.4 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 VDK86783.1 - 4.9e-07 29.2 7.1 6.4e-07 28.8 0.2 2.5 3 0 0 3 3 3 1 Glucose inhibited division protein A K_oxygenase PF13434.6 VDK86783.1 - 3.2e-06 26.5 1.1 0.035 13.2 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 VDK86783.1 - 3.7e-06 25.9 11.7 0.00013 20.8 0.9 3.6 4 0 0 4 4 4 2 HI0933-like protein FAD_binding_3 PF01494.19 VDK86783.1 - 4.1e-05 23.0 5.9 0.04 13.2 0.4 3.2 3 0 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.21 VDK86783.1 - 4.8e-05 22.8 5.3 0.026 13.8 0.3 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 VDK86783.1 - 0.0033 16.7 0.1 0.0033 16.7 0.1 2.2 2 1 1 3 3 3 1 Thi4 family Lycopene_cycl PF05834.12 VDK86783.1 - 0.0074 15.4 2.2 0.01 15.0 0.1 2.2 2 1 0 2 2 2 1 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 VDK86783.1 - 0.011 15.2 0.5 2.5 7.4 0.2 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 VDK86783.1 - 0.026 15.0 0.2 9 6.8 0.2 2.8 3 0 0 3 3 3 0 XdhC Rossmann domain 3HCDH_N PF02737.18 VDK86783.1 - 0.098 12.5 2.9 0.91 9.4 1.2 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 VDK86783.1 - 0.11 13.3 0.5 74 4.2 0.2 3.3 3 0 0 3 3 3 0 Oxidoreductase family, NAD-binding Rossmann fold DAO PF01266.24 VDK86783.1 - 0.27 10.8 16.6 1.1 8.8 0.4 4.0 2 2 1 4 4 4 0 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 VDK86783.1 - 0.62 9.6 4.9 9.9 5.7 0.4 2.5 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DCP2 PF05026.13 VDK86784.1 - 1.4e-27 95.8 0.3 3.1e-27 94.7 0.3 1.7 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 VDK86784.1 - 2.5e-14 53.4 0.0 4.7e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF1977 PF09320.11 VDK86785.1 - 1.9e-28 98.8 0.1 6.3e-28 97.1 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 VDK86785.1 - 2.8e-23 81.8 1.0 6.3e-23 80.7 1.0 1.6 1 0 0 1 1 1 1 DnaJ domain Tmemb_cc2 PF10267.9 VDK86785.1 - 0.1 11.7 5.0 0.042 13.0 1.7 1.9 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein HUN PF08729.10 VDK86795.1 - 0.17 11.9 0.0 0.21 11.6 0.0 1.1 1 0 0 1 1 1 0 HPC2 and ubinuclein domain MIF4G PF02854.19 VDK86797.1 - 2.1e-34 119.0 14.1 1.2e-33 116.6 14.1 2.2 1 1 0 1 1 1 1 MIF4G domain Lipase_2 PF01674.18 VDK86798.1 - 1.1e-50 172.2 0.0 1.2e-50 172.1 0.0 1.0 1 0 0 1 1 1 1 Lipase (class 2) Lipase_2 PF01674.18 VDK86799.1 - 3.7e-11 42.9 0.0 5.5e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 2) DnaJ PF00226.31 VDK86803.1 - 2.2e-16 59.7 0.1 4.3e-16 58.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain 4HB_MCP_1 PF12729.7 VDK86803.1 - 0.11 12.0 0.0 0.32 10.5 0.0 1.6 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction SseB_C PF14581.6 VDK86803.1 - 0.16 12.1 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 SseB protein C-terminal domain Acyl-CoA_dh_N PF02771.16 VDK86804.1 - 8.4e-09 36.1 0.0 1.8e-08 35.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Spo12 PF05032.12 VDK86804.1 - 8.3e-07 28.8 0.4 2.2e-06 27.5 0.4 1.7 1 0 0 1 1 1 1 Spo12 family Acyl-CoA_dh_1 PF00441.24 VDK86804.1 - 0.00041 20.6 0.0 0.00074 19.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain PI_PP_I PF18363.1 VDK86805.1 - 9.6e-05 22.5 2.3 0.0055 16.9 0.0 2.8 3 0 0 3 3 3 1 Phosphoinositide phosphatase insertion domain Bap31_Bap29_C PF18035.1 VDK86805.1 - 0.24 11.4 14.8 0.036 14.1 3.9 3.0 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Phage_GPO PF05929.11 VDK86805.1 - 1.4 8.5 15.3 1.1 8.8 2.2 2.5 2 1 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Csm1_N PF18504.1 VDK86805.1 - 4.2 7.8 14.7 4.4 7.7 0.2 3.7 3 0 0 3 3 3 0 Csm1 N-terminal domain TEX13 PF15186.6 VDK86805.1 - 6 6.5 14.6 0.31 10.7 7.0 2.5 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family TSC22 PF01166.18 VDK86805.1 - 7.8 6.9 12.3 7.4 7.0 0.2 3.7 3 2 1 4 4 4 0 TSC-22/dip/bun family Takusan PF04822.13 VDK86805.1 - 8.1 6.4 13.3 4.2 7.3 1.9 3.0 2 1 1 3 3 3 0 Takusan I_LWEQ PF01608.17 VDK86805.1 - 8.5 6.6 21.5 0.046 14.0 3.8 3.4 2 1 0 3 3 3 0 I/LWEQ domain CUT PF02376.15 VDK86808.1 - 7.1e-27 93.4 0.4 1.2e-26 92.7 0.4 1.3 1 0 0 1 1 1 1 CUT domain EGF PF00008.27 VDK86809.1 - 2.5e-76 251.5 219.8 4.3e-08 33.3 4.3 18.0 16 0 0 16 16 16 16 EGF-like domain Ephrin_rec_like PF07699.13 VDK86809.1 - 2e-66 219.5 101.5 1.7e-13 50.1 0.7 10.9 9 1 1 10 10 9 7 Putative ephrin-receptor like hEGF PF12661.7 VDK86809.1 - 9.2e-37 124.4 182.7 4e-05 24.1 4.2 19.3 18 0 0 18 18 16 15 Human growth factor-like EGF HYR PF02494.16 VDK86809.1 - 7.4e-25 87.1 6.9 7e-11 42.3 0.6 3.9 3 0 0 3 3 3 3 HYR domain EGF_2 PF07974.13 VDK86809.1 - 1.8e-12 47.4 241.9 0.0098 16.2 9.6 17.8 15 1 1 16 16 16 12 EGF-like domain Sushi PF00084.20 VDK86809.1 - 6.1e-12 45.9 55.8 1.3e-06 28.8 0.1 9.8 9 1 1 10 10 8 5 Sushi repeat (SCR repeat) F5_F8_type_C PF00754.25 VDK86809.1 - 7.1e-10 39.1 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 F5/8 type C domain EGF_3 PF12947.7 VDK86809.1 - 1.6e-09 37.8 222.3 5e-07 29.8 7.2 17.7 16 1 1 17 17 15 10 EGF domain Laminin_G_3 PF13385.6 VDK86809.1 - 1.3e-08 35.1 1.6 5.6e-08 33.1 0.5 2.2 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily cEGF PF12662.7 VDK86809.1 - 5.3e-05 23.0 4.4 5.3e-05 23.0 4.4 17.9 18 0 0 18 18 17 3 Complement Clr-like EGF-like LytR_C PF13399.6 VDK86809.1 - 0.0012 19.8 0.0 0.0026 18.7 0.0 1.5 1 0 0 1 1 1 1 LytR cell envelope-related transcriptional attenuator RRM_1 PF00076.22 VDK86811.1 - 7.7e-21 73.7 0.0 1.2e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 VDK86811.1 - 0.0044 17.0 0.0 0.0076 16.2 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif T4-gp15_tss PF16724.5 VDK86812.1 - 0.032 14.0 0.2 0.062 13.0 0.1 1.5 1 1 1 2 2 2 0 T4-like virus Myoviridae tail sheath stabiliser NUDIX PF00293.28 VDK86813.1 - 0.001 19.1 0.2 0.002 18.2 0.1 1.5 2 0 0 2 2 2 1 NUDIX domain RCC1 PF00415.18 VDK86815.1 - 5.8e-19 68.4 3.2 6.8e-13 49.0 0.3 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 VDK86815.1 - 1.5e-18 66.1 6.8 9e-11 41.3 4.0 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat SNF2_N PF00176.23 VDK86818.1 - 5.5e-69 232.5 0.0 1.7e-68 230.9 0.0 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 VDK86818.1 - 9.8e-07 29.1 0.1 2.6e-06 27.7 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 VDK86818.1 - 7e-06 25.8 7.2 7e-06 25.8 7.2 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK86818.1 - 3.3e-05 24.1 9.2 3.3e-05 24.1 9.2 3.6 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 VDK86818.1 - 0.0011 18.7 6.7 0.0011 18.7 6.7 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK86818.1 - 0.0013 18.5 6.5 0.0013 18.5 6.5 3.4 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK86818.1 - 0.0015 18.5 5.3 0.0015 18.5 5.3 3.3 3 0 0 3 3 3 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK86818.1 - 0.0089 15.9 5.2 0.0089 15.9 5.2 3.3 4 1 1 5 5 5 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 VDK86818.1 - 1.2 9.2 11.1 0.069 13.2 4.6 2.5 2 0 0 2 2 2 0 RING-type zinc-finger CCDC92 PF14916.6 VDK86823.1 - 0.00043 20.0 0.1 0.011 15.5 0.0 2.8 2 0 0 2 2 2 1 Coiled-coil domain of unknown function SpoIISA_toxin PF14171.6 VDK86823.1 - 0.075 12.7 1.3 0.13 12.0 0.3 1.9 2 1 0 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system Cep57_CLD_2 PF14197.6 VDK86823.1 - 5.5 7.2 12.9 32 4.7 3.0 4.3 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 NYD-SP28_assoc PF14775.6 VDK86823.1 - 8.1 6.6 6.2 25 5.0 0.0 4.0 4 0 0 4 4 4 0 Sperm tail C-terminal domain NicO PF03824.16 VDK86823.1 - 9.4 5.5 6.1 17 4.7 6.1 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Prp18 PF02840.15 VDK86824.1 - 7.8e-53 178.4 0.3 7.8e-53 178.4 0.3 1.8 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 VDK86824.1 - 1.8e-12 46.6 1.5 3.2e-12 45.8 1.5 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like polyprenyl_synt PF00348.17 VDK86826.1 - 2.6e-58 197.1 0.1 3.4e-58 196.7 0.1 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HeLo PF14479.6 VDK86826.1 - 0.029 14.2 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 Prion-inhibition and propagation BK_channel_a PF03493.18 VDK86828.1 - 1.9e-44 149.8 0.0 1.2e-28 99.1 0.0 2.5 1 1 1 2 2 2 2 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 VDK86828.1 - 1.4e-14 53.8 6.7 3.4e-14 52.6 6.7 1.6 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 VDK86828.1 - 1.7e-09 37.3 3.3 3.5e-09 36.3 3.3 1.4 1 0 0 1 1 1 1 Ion transport protein Lig_chan PF00060.26 VDK86828.1 - 0.0039 17.0 0.2 0.0075 16.1 0.2 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel TrkA_N PF02254.18 VDK86828.1 - 0.01 16.1 0.1 0.33 11.2 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain DUF913 PF06025.12 VDK86830.1 - 3.9e-81 272.9 1.8 3.9e-81 272.9 1.8 2.8 2 0 0 2 2 2 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 VDK86830.1 - 1.1e-23 84.3 8.6 2.1e-11 43.9 0.6 2.8 2 0 0 2 2 2 2 Domain of Unknown Function (DUF908) UBM PF14377.6 VDK86830.1 - 2.6e-23 80.7 14.4 7.3e-09 34.8 0.2 3.8 3 0 0 3 3 3 3 Ubiquitin binding region WWE PF02825.20 VDK86830.1 - 9.2e-10 39.0 0.1 2.8e-09 37.4 0.1 1.9 1 0 0 1 1 1 1 WWE domain UBA PF00627.31 VDK86830.1 - 0.00013 21.8 0.0 0.00043 20.1 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain Arm_2 PF04826.13 VDK86830.1 - 0.011 15.3 0.6 0.027 13.9 0.6 1.6 1 0 0 1 1 1 0 Armadillo-like ECSIT PF06239.11 VDK86832.1 - 4.6e-44 150.2 0.3 4.6e-44 150.2 0.3 1.5 2 0 0 2 2 2 1 Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C PF14784.6 VDK86832.1 - 1.4e-31 109.5 0.4 4e-31 108.1 0.2 1.8 2 0 0 2 2 2 1 C-terminal domain of the ECSIT protein Patched PF02460.18 VDK86837.1 - 1.7e-199 664.8 25.4 1.9e-187 625.0 23.2 2.0 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK86837.1 - 1.7e-43 148.1 18.4 2e-41 141.4 3.2 2.7 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK86837.1 - 0.0011 18.0 1.7 0.0011 18.0 1.7 2.9 2 2 0 2 2 2 1 MMPL family BTB PF00651.31 VDK86838.1 - 3.3e-15 56.3 0.2 2.3e-06 27.8 0.0 2.6 3 0 0 3 3 3 2 BTB/POZ domain zinc_ribbon_10 PF10058.9 VDK86838.1 - 0.24 11.1 6.3 0.62 9.8 6.3 1.7 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein TRAM_LAG1_CLN8 PF03798.16 VDK86841.1 - 1.4e-16 60.9 20.0 2.6e-16 60.0 20.0 1.5 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 VDK86841.1 - 8.3e-16 57.4 0.7 9.1e-15 54.1 0.2 2.8 2 0 0 2 2 2 1 TRAM1-like protein EF-hand_13 PF17958.1 VDK86842.1 - 5.7e-14 51.7 0.2 3.5e-13 49.2 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 VDK86842.1 - 1.9e-10 41.1 0.4 7.5e-09 35.9 0.2 3.6 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 VDK86842.1 - 3e-07 29.5 0.7 7.3e-05 22.0 0.3 2.9 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 VDK86842.1 - 5.8e-07 28.7 0.2 1.7e-06 27.3 0.2 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 VDK86842.1 - 1.5e-05 24.6 0.1 0.00045 19.9 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain DUF961 PF06125.11 VDK86842.1 - 0.0012 19.2 0.0 0.0035 17.7 0.0 1.8 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF961) EF-hand_8 PF13833.6 VDK86842.1 - 0.014 15.2 0.1 0.05 13.5 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain pair Beta-lactamase PF00144.24 VDK86843.1 - 1.9e-20 73.4 0.0 2.6e-20 72.9 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase KinB_sensor PF16767.5 VDK86843.1 - 0.057 13.9 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Sensor domain of alginate biosynthesis sensor protein KinB NifU_N PF01592.16 VDK86844.1 - 1.2e-35 122.4 0.3 1.3e-35 122.3 0.3 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Beta-lactamase PF00144.24 VDK86845.1 - 5.7e-34 117.8 0.0 6.3e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase CybS PF05328.12 VDK86845.1 - 0.002 17.8 0.0 0.0024 17.5 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Beta-lactamase2 PF13354.6 VDK86845.1 - 0.02 14.5 0.0 0.025 14.2 0.0 1.1 1 0 0 1 1 1 0 Beta-lactamase enzyme family Peptidase_S11 PF00768.20 VDK86845.1 - 0.035 13.5 0.1 0.044 13.2 0.1 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase RhoGEF PF00621.20 VDK86846.1 - 2.7e-26 92.9 10.7 2.7e-26 92.9 10.7 3.1 3 1 0 3 3 3 1 RhoGEF domain PH PF00169.29 VDK86846.1 - 4.2e-05 24.0 0.0 0.00016 22.1 0.0 2.0 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 VDK86846.1 - 0.005 17.1 0.0 0.021 15.1 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 VDK86846.1 - 0.16 12.4 1.3 15 6.1 0.1 2.9 2 0 0 2 2 2 0 Pleckstrin homology domain Vps5 PF09325.10 VDK86847.1 - 9.1e-14 51.6 4.7 3.5e-07 30.0 0.8 2.0 1 1 1 2 2 2 2 Vps5 C terminal like Pkinase PF00069.25 VDK86848.1 - 6.4e-56 189.6 0.0 9.5e-56 189.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86848.1 - 6.7e-44 150.1 0.0 1e-43 149.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 VDK86848.1 - 7.6e-20 70.9 1.7 1.1e-19 70.4 0.5 2.0 2 0 0 2 2 2 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase_fungal PF17667.1 VDK86848.1 - 4.8e-06 25.6 0.1 1.2e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 VDK86848.1 - 0.065 12.5 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Kinase-like CAP_N PF01213.19 VDK86849.1 - 0.041 13.4 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MADF_DNA_bdg PF10545.9 VDK86849.1 - 0.17 12.3 2.8 0.28 11.5 2.8 1.3 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Herpes_UL56 PF04534.12 VDK86849.1 - 1.2 8.5 6.4 0.13 11.7 1.3 2.0 2 0 0 2 2 2 0 Herpesvirus UL56 protein FAD_binding_3 PF01494.19 VDK86851.1 - 5.9e-19 68.5 0.0 1e-09 38.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.14 VDK86851.1 - 6.7e-06 25.2 0.1 0.076 11.8 0.0 2.3 2 0 0 2 2 2 2 Tryptophan halogenase SE PF08491.10 VDK86851.1 - 0.00025 20.2 0.0 0.00098 18.3 0.0 1.8 2 0 0 2 2 2 1 Squalene epoxidase DAO PF01266.24 VDK86851.1 - 0.00095 18.8 0.0 0.0029 17.3 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 VDK86851.1 - 0.0015 18.7 0.2 0.0059 16.8 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 VDK86851.1 - 0.0022 17.1 2.0 0.14 11.2 0.6 2.8 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 VDK86851.1 - 0.0024 17.2 0.1 0.5 9.5 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 VDK86851.1 - 0.037 14.3 0.0 0.072 13.4 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox PF00070.27 VDK86851.1 - 0.04 14.5 0.0 0.44 11.1 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Atx10homo_assoc PF09759.9 VDK86853.1 - 1.2e-16 60.5 1.0 4.4e-16 58.7 0.0 2.3 2 1 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Suppressor_P21 PF11479.8 VDK86853.1 - 0.034 14.3 3.6 0.15 12.3 0.3 2.9 3 0 0 3 3 3 0 RNA silencing suppressor P21 C-terminal domain Tetraspanin PF00335.20 VDK86855.1 - 1.1e-13 51.4 6.2 1.8e-13 50.8 6.2 1.4 1 0 0 1 1 1 1 Tetraspanin family DUF4199 PF13858.6 VDK86855.1 - 0.012 16.0 3.5 0.028 14.8 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Elongin_A PF06881.11 VDK86855.1 - 0.031 14.8 0.2 0.072 13.6 0.2 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A RA PF00788.23 VDK86856.1 - 3.9e-22 78.7 0.1 4.4e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 Ras association (RalGDS/AF-6) domain PI3K_rbd PF00794.18 VDK86856.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain ZYG-11_interact PF05884.12 VDK86862.1 - 8.6e-18 64.8 3.8 1e-17 64.5 3.8 1.0 1 0 0 1 1 1 1 Interactor of ZYG-11 YoqO PF14037.6 VDK86862.1 - 0.15 12.6 5.8 0.24 11.9 5.8 1.3 1 0 0 1 1 1 0 YoqO-like protein ELYS-bb PF16687.5 VDK86864.1 - 1.1e-11 44.1 0.1 4e-11 42.2 0.1 1.8 1 1 0 1 1 1 1 beta-propeller of ELYS nucleoporin ELYS PF13934.6 VDK86864.1 - 0.00026 21.0 0.0 0.00083 19.4 0.0 1.8 2 0 0 2 2 2 1 Nuclear pore complex assembly TFIIA PF03153.13 VDK86869.1 - 2.3e-55 189.3 31.9 2e-52 179.6 31.9 2.1 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF1380 PF07128.12 VDK86869.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1380) PDZ_2 PF13180.6 VDK86870.1 - 1.8e-11 44.2 0.2 6.3e-07 29.6 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK86870.1 - 5.7e-10 38.9 0.0 3.8e-06 26.7 0.0 2.8 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 VDK86870.1 - 4.4e-09 36.6 0.1 6.1e-05 23.3 0.2 2.3 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 VDK86870.1 - 6.4e-07 29.3 0.0 0.0094 15.9 0.0 2.5 2 0 0 2 2 2 2 Tricorn protease PDZ domain Phage_TTP_11 PF16460.5 VDK86870.1 - 0.037 13.9 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 Phage tail tube, TTP, lambda-like Peptidase_C62 PF12380.8 VDK86870.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Gill-associated viral 3C-like peptidase PDZ_1 PF12812.7 VDK86870.1 - 0.2 11.7 0.5 1.3 9.1 0.0 2.3 2 1 0 2 2 2 0 PDZ-like domain Neur_chan_LBD PF02931.23 VDK86871.1 - 4.9e-38 130.7 0.4 1e-37 129.7 0.4 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK86871.1 - 2.3e-25 90.1 0.7 4.4e-25 89.1 0.3 1.6 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region COMM_domain PF07258.14 VDK86876.1 - 1.6e-06 28.2 0.0 2.1e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 COMM domain DAGK_cat PF00781.24 VDK86877.1 - 3.3e-22 78.5 0.1 5.6e-22 77.7 0.1 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF498 PF04430.14 VDK86877.1 - 0.094 12.8 0.0 0.59 10.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF498/DUF598) Sec10 PF07393.11 VDK86878.1 - 0.031 12.7 3.3 0.036 12.5 3.3 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec10 Sin3a_C PF16879.5 VDK86879.1 - 0.039 13.7 0.1 0.047 13.4 0.1 1.1 1 0 0 1 1 1 0 C-terminal domain of Sin3a protein Myb_DNA-bind_5 PF13873.6 VDK86884.1 - 5.7e-07 29.5 3.2 0.0037 17.3 0.2 2.7 2 0 0 2 2 2 2 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 VDK86884.1 - 0.00011 22.4 1.3 0.11 12.8 0.0 2.9 2 0 0 2 2 2 2 Alcohol dehydrogenase transcription factor Myb/SANT-like DUF4294 PF14127.6 VDK86884.1 - 0.0033 17.4 1.5 0.91 9.4 0.1 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4294) SipA PF09052.10 VDK86884.1 - 0.09 12.4 1.3 0.22 11.1 0.0 2.2 3 0 0 3 3 3 0 SipA N-terminal domain EnY2 PF10163.9 VDK86884.1 - 0.15 12.4 1.7 1.1 9.7 0.6 2.6 2 1 1 3 3 3 0 Transcription factor e(y)2 eIF3_p135 PF12807.7 VDK86884.1 - 0.45 10.5 5.7 5.7 6.9 0.1 3.0 2 1 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Mitofilin PF09731.9 VDK86884.1 - 1.8 7.3 10.2 0.076 11.8 1.5 2.2 2 0 0 2 2 2 0 Mitochondrial inner membrane protein Tetraspanin PF00335.20 VDK86886.1 - 1.6e-12 47.6 15.4 3.7e-12 46.4 15.4 1.5 1 1 0 1 1 1 1 Tetraspanin family Phage_holin_3_6 PF07332.11 VDK86886.1 - 0.0035 17.4 1.5 2.5 8.2 0.0 2.3 2 0 0 2 2 2 2 Putative Actinobacterial Holin-X, holin superfamily III Pox_G7 PF05503.12 VDK86886.1 - 0.0067 15.4 0.4 0.011 14.7 0.3 1.4 1 1 0 1 1 1 1 Poxvirus G7-like PrgI PF12666.7 VDK86886.1 - 0.0085 16.8 4.8 0.052 14.3 0.5 2.5 2 0 0 2 2 2 1 PrgI family protein Ion_trans_2 PF07885.16 VDK86887.1 - 7.8e-09 35.4 0.3 8.7e-09 35.2 0.3 1.1 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 VDK86887.1 - 2.7e-07 30.1 0.0 2.9e-07 30.0 0.0 1.0 1 0 0 1 1 1 1 Ion transport protein Cyclin_N PF00134.23 VDK86891.1 - 1.5e-23 82.9 0.2 6.3e-22 77.7 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 VDK86891.1 - 1.1e-09 38.5 0.3 2.1e-09 37.5 0.3 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain LSM PF01423.22 VDK86892.1 - 1.2e-11 44.1 0.1 1.5e-11 43.8 0.1 1.1 1 0 0 1 1 1 1 LSM domain HCNGP PF07818.13 VDK86893.1 - 3.5e-28 98.1 0.1 9.9e-28 96.6 0.1 1.8 1 0 0 1 1 1 1 HCNGP-like protein DUF2407_C PF13373.6 VDK86893.1 - 1.9 8.7 4.3 16 5.7 0.5 2.3 2 0 0 2 2 2 0 DUF2407 C-terminal domain FXa_inhibition PF14670.6 VDK86897.1 - 1.1e-44 150.3 79.7 5.4e-11 42.6 8.8 5.2 5 0 0 5 5 5 5 Coagulation Factor Xa inhibitory site cEGF PF12662.7 VDK86897.1 - 2.2e-22 78.6 43.8 7e-07 29.1 2.9 6.3 6 0 0 6 6 6 5 Complement Clr-like EGF-like EGF_CA PF07645.15 VDK86897.1 - 1.3e-16 60.4 74.6 4.2e-09 36.5 6.1 5.6 4 2 1 5 5 5 5 Calcium-binding EGF domain EGF PF00008.27 VDK86897.1 - 4e-05 23.8 69.4 0.00039 20.7 4.7 7.3 6 2 0 6 6 6 3 EGF-like domain EGF_3 PF12947.7 VDK86897.1 - 0.00043 20.4 73.2 0.74 10.1 8.0 6.4 5 2 0 5 5 5 5 EGF domain EGF_MSP1_1 PF12946.7 VDK86897.1 - 0.042 13.9 4.2 0.042 13.9 4.2 5.9 5 1 0 5 5 5 0 MSP1 EGF domain 1 hEGF PF12661.7 VDK86897.1 - 0.076 13.7 4.6 0.076 13.7 4.6 8.2 7 2 1 8 8 8 0 Human growth factor-like EGF FixH PF05751.11 VDK86898.1 - 0.016 15.2 0.2 0.018 15.0 0.2 1.1 1 0 0 1 1 1 0 FixH Importin_rep_4 PF18808.1 VDK86898.1 - 1 9.7 7.0 1.5 9.2 7.0 1.3 1 0 0 1 1 1 0 Importin repeat ANAPC4_WD40 PF12894.7 VDK86902.1 - 0.008 16.5 0.3 45 4.5 0.0 4.5 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Tam41_Mmp37 PF09139.11 VDK86904.1 - 4.7e-87 292.4 0.0 5.4e-87 292.2 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial ODC_AZ PF02100.17 VDK86905.1 - 6.7e-12 45.4 0.0 9e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme TPR_2 PF07719.17 VDK86906.1 - 3.9e-24 82.8 16.4 0.0045 17.0 0.0 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 VDK86906.1 - 3.1e-22 77.4 5.3 3e-05 23.7 0.0 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDK86906.1 - 6.8e-19 66.5 1.2 0.15 12.3 0.0 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 VDK86906.1 - 1.2e-18 67.4 8.6 3.1e-07 30.8 0.4 7.1 6 1 1 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK86906.1 - 8.6e-18 64.4 26.8 2.6e-11 43.6 5.2 5.5 5 1 0 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 VDK86906.1 - 2.9e-15 55.6 0.0 0.0068 16.1 0.0 5.3 4 1 1 5 5 5 3 TPR repeat TPR_17 PF13431.6 VDK86906.1 - 3.9e-14 51.9 9.5 0.0018 18.5 0.6 8.1 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 VDK86906.1 - 2.2e-13 50.6 11.7 9.8e-05 22.9 0.1 7.4 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 VDK86906.1 - 5.8e-11 42.3 17.4 0.023 15.5 0.1 7.8 5 1 3 9 9 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 VDK86906.1 - 3.3e-09 36.8 9.9 0.038 14.6 0.2 8.2 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDK86906.1 - 7.8e-08 32.4 8.8 0.0048 17.0 0.2 4.6 2 1 3 5 5 4 4 Tetratricopeptide repeat TPR_15 PF13429.6 VDK86906.1 - 2.7e-06 26.8 4.5 0.0081 15.4 0.3 4.2 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK86906.1 - 1e-05 25.7 24.1 0.097 13.0 0.1 7.6 5 2 2 7 7 7 3 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 VDK86906.1 - 0.041 13.5 3.2 1.3 8.7 0.1 3.3 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) ChAPs PF09295.10 VDK86906.1 - 0.079 11.9 2.3 2.9 6.8 0.5 3.5 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF4192 PF13830.6 VDK86906.1 - 0.48 10.4 3.4 4 7.4 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4192) TPR_20 PF14561.6 VDK86906.1 - 1.6 9.1 6.6 0.57 10.5 0.6 3.2 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 VDK86906.1 - 4.8 8.1 9.5 6.4 7.7 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat PDE4_UCR PF18100.1 VDK86908.1 - 2.1e-48 163.8 0.0 3.2e-48 163.3 0.0 1.3 1 0 0 1 1 1 1 Phosphodiesterase 4 upstream conserved regions (UCR) Laminin_EGF PF00053.24 VDK86913.1 - 0.00077 19.6 39.0 1.8 8.7 6.0 4.6 1 1 3 4 4 4 4 Laminin EGF domain EGF_2 PF07974.13 VDK86913.1 - 0.0051 17.1 38.8 0.14 12.6 2.1 5.6 5 0 0 5 5 5 3 EGF-like domain EGF PF00008.27 VDK86913.1 - 0.072 13.4 2.0 0.072 13.4 2.0 6.3 5 2 1 6 6 6 0 EGF-like domain hEGF PF12661.7 VDK86913.1 - 0.078 13.6 0.2 0.078 13.6 0.2 6.0 5 1 0 5 5 5 0 Human growth factor-like EGF MAM PF00629.23 VDK86914.1 - 0.0002 21.3 2.3 0.19 11.6 0.0 3.0 3 1 0 3 3 3 2 MAM domain, meprin/A5/mu DUF1059 PF06348.11 VDK86914.1 - 0.23 11.7 0.2 5 7.4 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1059) Pkinase PF00069.25 VDK86915.1 - 6.1e-68 229.0 0.0 7.6e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK86915.1 - 1.6e-25 89.9 0.0 2.1e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK86915.1 - 1.7e-06 27.6 0.1 6.7e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 VDK86915.1 - 0.00064 19.1 0.1 0.00098 18.5 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK86915.1 - 0.0023 17.9 0.1 0.028 14.3 0.1 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 VDK86915.1 - 0.048 13.2 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1679 PF07914.11 VDK86915.1 - 0.09 11.6 0.4 0.16 10.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Death PF00531.22 VDK86916.1 - 0.16 12.2 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 Death domain Mito_carr PF00153.27 VDK86917.1 - 1e-58 195.2 0.3 6e-19 67.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HAD_2 PF13419.6 VDK86924.1 - 3.5e-19 69.6 0.0 4.5e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 VDK86924.1 - 2.2e-11 44.5 0.0 2.8e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 VDK86924.1 - 9.1e-10 38.5 0.0 1.8e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_3 PF08282.12 VDK86924.1 - 0.0017 18.1 0.1 0.9 9.2 0.0 2.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDK86924.1 - 0.08 13.3 0.0 0.099 13.0 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase GMC_oxred_N PF00732.19 VDK86925.1 - 4.5e-87 292.2 0.0 6.5e-87 291.6 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 VDK86925.1 - 5e-34 117.9 0.0 9e-34 117.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 VDK86925.1 - 1.9e-05 23.9 0.0 3.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 VDK86925.1 - 0.00052 20.2 0.0 0.0012 19.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 VDK86925.1 - 0.0075 15.4 0.0 0.021 13.9 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 VDK86925.1 - 0.0082 15.8 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 VDK86925.1 - 0.056 12.7 0.0 0.12 11.6 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 VDK86925.1 - 0.057 12.6 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 VDK86925.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 VDK86925.1 - 0.16 10.6 0.0 0.27 9.9 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein PGAP1 PF07819.13 VDK86926.1 - 0.00056 19.7 0.0 0.001 18.8 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 VDK86926.1 - 0.00072 20.2 0.2 0.0013 19.4 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 VDK86926.1 - 0.0037 16.6 0.0 0.0089 15.3 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LCAT PF02450.15 VDK86926.1 - 0.031 13.5 0.0 0.049 12.8 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.13 VDK86926.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Serine hydrolase Herpes_UL49_2 PF04823.12 VDK86926.1 - 0.49 10.5 2.7 24 5.1 0.0 3.0 3 0 0 3 3 3 0 Herpesvirus UL49 tegument protein CENP-F_leu_zip PF10473.9 VDK86932.1 - 0.0063 16.5 13.6 0.0063 16.5 13.6 4.6 2 2 2 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HLH PF00010.26 VDK86932.1 - 0.012 15.5 4.0 0.025 14.5 2.3 2.6 2 0 0 2 2 2 0 Helix-loop-helix DNA-binding domain Cytochrome_C7 PF14522.6 VDK86932.1 - 0.069 13.2 1.0 0.51 10.4 1.0 2.6 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c WH2 PF02205.20 VDK86933.1 - 1.6e-08 34.1 0.0 6e-05 22.7 0.0 2.4 2 0 0 2 2 2 2 WH2 motif LytR_C PF13399.6 VDK86933.1 - 0.08 13.9 0.1 0.15 13.1 0.1 1.5 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator BTB PF00651.31 VDK86934.1 - 3.8e-14 52.9 0.3 5.7e-12 45.8 0.0 3.2 2 1 1 3 3 3 2 BTB/POZ domain BACK PF07707.15 VDK86934.1 - 1.6e-06 28.1 0.9 3.4e-06 27.1 0.1 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Phage_Gp23 PF10669.9 VDK86935.1 - 0.16 12.3 2.8 0.32 11.3 2.1 1.9 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) HutP PF09021.11 VDK86935.1 - 0.32 11.3 3.9 0.7 10.2 3.9 1.5 1 0 0 1 1 1 0 HutP OrsD PF12013.8 VDK86935.1 - 1.2 9.5 4.2 0.54 10.7 0.2 2.4 2 1 1 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D RabGAP-TBC PF00566.18 VDK86941.1 - 2e-50 171.4 0.1 4.4e-50 170.3 0.1 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain BssB_TutG PF18512.1 VDK86941.1 - 0.059 13.3 0.6 0.37 10.7 0.3 2.3 2 0 0 2 2 2 0 Benzylsuccinate synthase beta subunit GTF2I PF02946.14 VDK86941.1 - 0.06 13.4 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 GTF2I-like repeat NAM-associated PF14303.6 VDK86941.1 - 2.4 8.8 5.9 4.4 8.0 5.9 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF4142 PF13628.6 VDK86941.1 - 5.9 7.1 6.2 6.7 6.9 0.4 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4142) Methyltransf_8 PF05148.15 VDK86948.1 - 1.9e-12 47.5 0.1 3.7e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase DUF1943 PF09172.11 VDK86948.1 - 0.12 11.6 3.3 0.12 11.6 3.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DUF4500 PF14937.6 VDK86948.1 - 0.18 11.9 0.0 0.18 11.9 0.0 2.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4500) NOG1_N PF17835.1 VDK86950.1 - 2e-50 170.9 8.6 2.5e-50 170.6 4.0 2.6 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOG1 PF06858.14 VDK86950.1 - 1e-25 89.2 0.2 2.8e-25 87.9 0.2 1.8 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) NOGCT PF08155.11 VDK86950.1 - 2e-21 75.7 0.6 5.5e-21 74.3 0.6 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 VDK86950.1 - 2.3e-18 66.3 0.0 6.6e-18 64.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK86950.1 - 2.7e-12 46.5 0.1 6.5e-12 45.2 0.1 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 VDK86950.1 - 2.4e-05 24.3 0.7 0.069 13.1 0.0 3.7 3 1 0 3 3 3 2 RsgA GTPase SRPRB PF09439.10 VDK86950.1 - 0.0014 18.1 0.3 0.015 14.7 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 VDK86950.1 - 0.0036 17.4 2.1 2.7 8.0 0.0 3.3 2 1 1 3 3 3 2 Dynamin family AAA_16 PF13191.6 VDK86950.1 - 0.072 13.5 0.0 0.29 11.5 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 VDK86950.1 - 0.11 12.8 0.7 1.8 8.9 0.0 3.2 2 1 1 3 3 3 0 AAA domain GvpL_GvpF PF06386.11 VDK86950.1 - 0.17 11.8 2.5 0.48 10.3 2.5 1.7 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Y_phosphatase PF00102.27 VDK86958.1 - 8.5e-127 421.5 0.8 9.4e-52 175.9 0.0 3.3 3 0 0 3 3 3 3 Protein-tyrosine phosphatase fn3 PF00041.21 VDK86958.1 - 2.4e-08 34.2 0.1 0.021 15.2 0.1 3.7 2 1 0 2 2 2 2 Fibronectin type III domain V-set PF07686.17 VDK86958.1 - 5.9e-05 23.2 0.0 0.00023 21.3 0.0 2.0 1 0 0 1 1 1 1 Immunoglobulin V-set domain PTPlike_phytase PF14566.6 VDK86958.1 - 0.00053 20.1 0.0 0.0036 17.4 0.0 2.4 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 VDK86958.1 - 0.0012 18.9 0.0 0.003 17.6 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 VDK86958.1 - 0.0032 17.3 0.0 0.011 15.6 0.0 1.9 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain ig PF00047.25 VDK86958.1 - 0.025 14.7 0.0 0.067 13.4 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain I-set PF07679.16 VDK86958.1 - 0.05 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin I-set domain dCMP_cyt_deam_1 PF00383.23 VDK86959.1 - 8.6e-18 64.1 0.4 1.1e-17 63.8 0.4 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 VDK86959.1 - 1.1e-12 48.3 2.5 2.4e-11 44.0 0.6 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 VDK86959.1 - 0.0044 16.6 1.2 1.5 8.4 0.2 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases OST3_OST6 PF04756.13 VDK86959.1 - 0.046 13.1 0.0 0.052 12.9 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Phage_lysis PF03245.13 VDK86959.1 - 0.084 13.0 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein RRM_1 PF00076.22 VDK86963.1 - 3.1e-13 49.3 0.1 5.6e-13 48.5 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK86963.1 - 0.0086 16.2 0.0 0.03 14.4 0.1 2.0 2 1 0 2 2 2 1 RNA recognition motif RRM_1 PF00076.22 VDK86964.1 - 4.7e-17 61.6 0.0 7.1e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK86964.1 - 1.7e-05 24.8 0.0 4.2e-05 23.6 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif AAR2 PF05282.11 VDK86968.1 - 3.4e-90 303.0 0.1 4.2e-90 302.7 0.1 1.1 1 0 0 1 1 1 1 AAR2 protein ORC2 PF04084.14 VDK86971.1 - 7.1e-60 202.7 1.3 1.1e-59 202.0 1.3 1.3 1 0 0 1 1 1 1 Origin recognition complex subunit 2 EspA PF03433.13 VDK86971.1 - 0.036 13.9 0.2 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 EspA-like secreted protein Clat_adaptor_s PF01217.20 VDK86972.1 - 8.2e-24 84.2 0.8 1e-23 83.8 0.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain 7tm_1 PF00001.21 VDK86976.1 - 2.2e-16 60.0 10.7 3.4e-16 59.4 10.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK86976.1 - 0.0015 17.9 6.6 0.0027 17.2 6.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx CobS PF02654.15 VDK86976.1 - 0.069 13.3 2.0 0.13 12.5 2.0 1.4 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase CENP-F_leu_zip PF10473.9 VDK86978.1 - 0.0021 18.1 4.6 0.0021 18.1 4.6 2.0 2 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ALIX_LYPXL_bnd PF13949.6 VDK86978.1 - 0.0029 16.9 2.3 0.0044 16.4 1.0 1.8 1 1 1 2 2 2 2 ALIX V-shaped domain binding to HIV MA-Mit PF09245.10 VDK86978.1 - 0.006 16.1 0.2 0.016 14.7 0.0 1.7 2 0 0 2 2 2 1 Mycoplasma arthritidis-derived mitogen DASH_Dad2 PF08654.10 VDK86978.1 - 0.021 15.2 1.6 0.77 10.2 0.2 2.6 1 1 1 2 2 2 0 DASH complex subunit Dad2 NIT PF08376.10 VDK86978.1 - 0.11 12.9 0.8 0.57 10.6 0.1 2.0 2 0 0 2 2 2 0 Nitrate and nitrite sensing PI3K_P85_iSH2 PF16454.5 VDK86978.1 - 0.18 11.4 6.4 0.025 14.2 1.4 2.0 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SesA PF17107.5 VDK86978.1 - 0.21 11.8 1.9 0.53 10.5 0.5 2.3 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases LMBR1 PF04791.16 VDK86978.1 - 0.27 10.1 2.5 0.35 9.7 2.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Occludin_ELL PF07303.13 VDK86978.1 - 0.3 11.8 3.0 0.92 10.3 0.4 2.8 2 1 0 2 2 2 0 Occludin homology domain AATF-Che1 PF13339.6 VDK86978.1 - 0.46 11.2 9.2 7.7 7.2 9.2 2.2 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor HMMR_N PF15905.5 VDK86978.1 - 4.4 6.7 9.7 0.26 10.7 2.1 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF724 PF05266.14 VDK86978.1 - 9.5 6.0 8.5 8.7 6.1 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) C2 PF00168.30 VDK86982.1 - 8.8e-34 115.9 0.0 3.6e-18 65.7 0.0 2.6 3 0 0 3 3 3 2 C2 domain Xpo1 PF08389.12 VDK86982.1 - 0.14 12.2 0.2 0.46 10.5 0.2 1.8 2 0 0 2 2 2 0 Exportin 1-like protein C2 PF00168.30 VDK86984.1 - 7e-47 158.0 1.0 2.8e-23 82.2 0.3 2.1 2 0 0 2 2 2 2 C2 domain CEP76-C2 PF15627.6 VDK86984.1 - 0.00015 21.4 0.0 0.44 10.1 0.0 2.4 2 1 0 2 2 2 2 CEP76 C2 domain DOCK-C2 PF14429.6 VDK86984.1 - 0.0038 17.1 0.1 0.31 10.8 0.0 2.2 2 0 0 2 2 2 2 C2 domain in Dock180 and Zizimin proteins PI3K_C2 PF00792.24 VDK86984.1 - 0.0084 16.0 0.2 0.078 12.9 0.0 2.2 2 1 0 2 2 2 1 Phosphoinositide 3-kinase C2 YedD PF13987.6 VDK86984.1 - 0.048 13.5 0.0 0.098 12.5 0.0 1.5 1 0 0 1 1 1 0 YedD-like protein Cadherin PF00028.17 VDK86986.1 - 1.4e-265 858.9 26.6 1.4e-15 57.5 0.0 27.4 27 0 0 27 27 27 26 Cadherin domain Cadherin_2 PF08266.12 VDK86986.1 - 6.1e-20 70.8 1.5 1 9.2 0.0 13.7 15 0 0 15 15 15 5 Cadherin-like Laminin_G_2 PF02210.24 VDK86986.1 - 5.2e-18 65.8 0.0 2e-17 63.9 0.0 2.2 1 0 0 1 1 1 1 Laminin G domain EGF PF00008.27 VDK86986.1 - 4.4e-15 55.6 49.9 3.3e-05 24.1 8.3 4.6 4 0 0 4 4 4 4 EGF-like domain RET_CLD1 PF17756.1 VDK86986.1 - 1.8e-14 54.1 0.0 0.8 10.0 0.0 10.2 10 1 1 11 11 11 2 RET Cadherin like domain 1 Laminin_G_1 PF00054.23 VDK86986.1 - 2.2e-11 44.1 0.0 6.3e-11 42.6 0.0 1.9 1 0 0 1 1 1 1 Laminin G domain Cadherin_pro PF08758.11 VDK86986.1 - 2e-09 37.5 0.1 1.3 9.3 0.0 10.1 11 0 0 11 11 11 1 Cadherin prodomain like Cadherin_3 PF16184.5 VDK86986.1 - 1.1e-07 31.8 27.9 2.4 8.2 0.1 12.6 14 1 0 14 14 14 3 Cadherin-like He_PIG PF05345.12 VDK86986.1 - 0.042 14.0 0.4 86 3.4 0.1 5.2 3 0 0 3 3 3 0 Putative Ig domain EGF_2 PF07974.13 VDK86986.1 - 7.3 7.0 46.6 0.98 9.8 9.7 4.5 4 0 0 4 4 4 0 EGF-like domain Astacin PF01400.24 VDK86987.1 - 1.4e-67 227.0 0.4 2.1e-67 226.5 0.4 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) CUB PF00431.20 VDK86987.1 - 1.2e-05 25.6 0.2 3.7e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 CUB domain Peptidase_M66 PF10462.9 VDK86987.1 - 0.015 14.3 1.0 0.025 13.6 1.0 1.3 1 0 0 1 1 1 0 Peptidase M66 Reprolysin_4 PF13583.6 VDK86987.1 - 0.074 12.7 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 VDK86987.1 - 0.085 12.7 0.1 0.63 9.9 0.0 2.1 2 0 0 2 2 2 0 Matrixin Phospholamban PF04272.14 VDK86987.1 - 0.092 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Phospholamban Tweety PF04906.13 VDK86988.1 - 8.8e-34 116.8 11.2 1.1e-33 116.5 11.2 1.0 1 0 0 1 1 1 1 Tweety DUF3810 PF12725.7 VDK86988.1 - 0.0069 15.8 4.7 0.06 12.7 1.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3810) DUF1345 PF07077.11 VDK86988.1 - 0.039 13.6 4.5 0.47 10.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) NPV_P10 PF05531.12 VDK86988.1 - 0.056 13.9 0.3 0.62 10.6 0.1 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Zn_ribbon_SprT PF17283.2 VDK86988.1 - 0.47 10.4 3.4 0.99 9.4 1.1 2.2 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DUF4131 PF13567.6 VDK86988.1 - 1.2 8.8 14.0 0.58 9.8 2.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) GWT1 PF06423.12 VDK86988.1 - 3.1 7.9 15.0 0.075 13.2 4.9 2.9 2 1 0 3 3 3 0 GWT1 Pex24p PF06398.11 VDK86988.1 - 3.5 6.5 7.6 2.1 7.3 5.3 1.8 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin Oxidored_q3 PF00499.20 VDK86988.1 - 7.1 6.4 15.1 1.6e+03 -1.3 0.0 3.1 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Tetraspanin PF00335.20 VDK86988.1 - 8.4 6.0 18.5 1.1 8.9 7.2 2.6 2 1 0 2 2 2 0 Tetraspanin family Str_synth PF03088.16 VDK86991.1 - 2.6e-27 94.8 0.0 7.2e-27 93.4 0.0 1.7 2 0 0 2 2 2 1 Strictosidine synthase SGL PF08450.12 VDK86991.1 - 1.9e-09 37.5 0.0 3.5e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 VDK86991.1 - 0.15 12.3 0.0 0.94 9.7 0.0 2.1 2 0 0 2 2 2 0 Arylesterase Sgf11 PF08209.11 VDK86993.1 - 5.9e-18 64.1 0.3 9.4e-18 63.5 0.3 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) PGA2 PF07543.12 VDK86993.1 - 0.0061 16.5 2.4 0.0093 15.9 2.4 1.2 1 0 0 1 1 1 1 Protein trafficking PGA2 PBP1_TM PF14812.6 VDK86993.1 - 0.04 14.3 5.2 0.074 13.4 5.2 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Bestrophin PF01062.21 VDK86994.1 - 2.3e-99 332.5 8.0 3.2e-99 332.1 8.0 1.2 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Cir_Bir_Yir PF06022.11 VDK86994.1 - 0.022 14.3 0.1 0.048 13.1 0.1 1.5 1 0 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir TSP_1 PF00090.19 VDK86998.1 - 0.00087 19.5 8.5 0.0016 18.6 8.5 1.5 1 0 0 1 1 1 1 Thrombospondin type 1 domain DUF1979 PF09322.10 VDK86998.1 - 0.041 13.8 0.1 0.078 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1979) zf-C2H2_4 PF13894.6 VDK86999.1 - 0.021 15.6 1.0 0.021 15.6 1.0 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger DUF629 PF04780.12 VDK86999.1 - 0.062 11.8 0.1 0.085 11.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2HE PF16278.5 VDK86999.1 - 0.28 11.7 3.9 0.36 11.3 2.7 1.8 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 VDK86999.1 - 1.4 9.6 6.7 0.25 11.9 1.8 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK87000.1 - 0.013 16.3 3.1 0.014 16.1 1.2 2.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK87000.1 - 0.026 15.0 2.2 0.026 15.0 2.2 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 VDK87000.1 - 0.33 11.3 0.2 0.33 11.3 0.2 2.8 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding HMG_box PF00505.19 VDK87003.1 - 7.4e-26 90.4 1.3 1.2e-25 89.7 1.3 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK87003.1 - 4.5e-09 36.8 0.9 8.4e-09 35.9 0.9 1.5 1 0 0 1 1 1 1 HMG-box domain CAP_N PF01213.19 VDK87003.1 - 2.9 7.3 8.5 7 6.0 8.5 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Ferrochelatase PF00762.19 VDK87004.1 - 5.8e-16 58.5 0.1 1.4e-15 57.2 0.1 1.7 1 1 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 VDK87004.1 - 0.18 12.2 0.0 0.39 11.1 0.0 1.5 1 0 0 1 1 1 0 CbiX SMC_N PF02463.19 VDK87007.1 - 1.4e-66 224.1 25.1 9.4e-66 221.4 25.1 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 VDK87007.1 - 4.3e-22 78.6 0.0 1.4e-21 76.9 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 VDK87007.1 - 4e-15 56.4 1.0 4e-15 56.4 1.0 4.5 3 2 0 4 4 4 1 AAA ATPase domain AAA_21 PF13304.6 VDK87007.1 - 2.1e-10 40.9 0.9 9.3e-06 25.7 0.1 4.1 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 VDK87007.1 - 3.4e-05 23.5 0.0 8.3e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain HWE_HK PF07536.14 VDK87007.1 - 0.05 14.3 0.8 1.1 10.0 0.1 3.4 2 0 0 2 2 2 0 HWE histidine kinase ABC_tran PF00005.27 VDK87007.1 - 0.2 12.2 0.0 0.2 12.2 0.0 6.2 4 2 0 4 4 4 0 ABC transporter GDYXXLXY PF14345.6 VDK87008.1 - 0.029 14.2 0.1 0.04 13.7 0.1 1.2 1 0 0 1 1 1 0 GDYXXLXY protein DNA_pol3_delta2 PF13177.6 VDK87015.1 - 2.1e-12 47.1 0.2 6.9e-12 45.4 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 VDK87015.1 - 2e-07 31.1 0.0 3.3e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 VDK87015.1 - 2e-05 25.0 0.1 8e-05 23.1 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 VDK87015.1 - 0.00015 22.1 0.9 0.00068 20.0 0.0 2.5 3 0 0 3 3 3 1 Replication factor C C-terminal domain AAA_16 PF13191.6 VDK87015.1 - 0.00019 21.9 0.0 0.00051 20.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain DNA_pol3_delta PF06144.13 VDK87015.1 - 0.0049 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_assoc_2 PF16193.5 VDK87015.1 - 0.0051 17.1 0.0 0.014 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_22 PF13401.6 VDK87015.1 - 0.0073 16.6 0.1 0.071 13.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain ATPgrasp_ST PF14397.6 VDK87015.1 - 0.0091 15.3 0.1 0.016 14.5 0.1 1.3 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp S6PP PF05116.13 VDK87015.1 - 0.021 14.4 0.2 0.053 13.1 0.2 1.7 1 1 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase AAA_24 PF13479.6 VDK87015.1 - 0.034 13.9 0.0 0.064 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Prenyltransf PF01255.19 VDK87015.1 - 0.2 11.2 1.5 0.52 9.8 1.5 1.8 1 1 0 1 1 1 0 Putative undecaprenyl diphosphate synthase RNA_pol_Rpb8 PF03870.15 VDK87016.1 - 5.4e-51 172.4 0.1 6.1e-51 172.3 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 VDK87016.1 - 0.009 16.1 0.1 0.16 12.0 0.1 2.1 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G tRNA-synt_1d PF00750.19 VDK87017.1 - 1.6e-109 366.1 0.2 7.6e-109 363.8 0.2 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 VDK87017.1 - 1.2e-20 73.9 0.0 5.4e-20 71.8 0.0 2.2 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain DALR_1 PF05746.15 VDK87017.1 - 3.9e-18 65.7 0.0 1.8e-17 63.6 0.0 2.2 1 0 0 1 1 1 1 DALR anticodon binding domain HTH_36 PF13730.6 VDK87017.1 - 0.0053 16.7 0.1 0.024 14.6 0.0 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain tRNA-synt_1e PF01406.19 VDK87017.1 - 0.012 15.0 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain CH PF00307.31 VDK87025.1 - 3.4e-37 126.9 14.2 2e-19 69.7 0.0 5.7 6 0 0 6 6 6 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK87025.1 - 9.5e-13 47.8 0.7 4.1e-05 23.3 0.0 4.0 3 0 0 3 3 3 2 CAMSAP CH domain UCH PF00443.29 VDK87025.1 - 9.8e-06 25.2 0.4 3.5 7.0 0.0 6.9 3 2 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase DUF1932 PF09130.11 VDK87025.1 - 0.06 13.3 1.0 1.6 8.8 0.0 3.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1932) SlyX PF04102.12 VDK87025.1 - 0.1 13.2 0.1 0.1 13.2 0.1 14.1 14 2 1 15 15 14 0 SlyX IL32 PF15225.6 VDK87025.1 - 0.22 11.9 3.0 0.87 10.0 0.1 3.8 3 0 0 3 3 2 0 Interleukin 32 DUF575 PF04746.12 VDK87025.1 - 0.27 11.5 1.3 1.7 8.9 0.3 3.1 2 0 0 2 2 1 0 Protein of unknown function (DUF575) EF-hand_14 PF17959.1 VDK87025.1 - 0.31 11.4 6.0 0.76 10.2 0.0 5.2 4 0 0 4 4 4 0 EF-hand domain BTAD PF03704.17 VDK87025.1 - 4.6 7.7 13.2 0.37 11.2 1.7 3.8 3 0 0 3 3 3 0 Bacterial transcriptional activator domain IMPa_helical PF18642.1 VDK87025.1 - 5.7 7.4 8.2 4.9 7.6 0.2 5.3 4 0 0 4 4 4 0 Immunomodulating metalloprotease helical domain DUF1110 PF06533.12 VDK87025.1 - 6.7 6.6 10.2 7.1 6.5 0.1 5.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1110) Glyco_transf_8 PF01501.20 VDK87029.1 - 3.6e-20 72.6 0.1 1.1e-18 67.8 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 VDK87029.1 - 0.018 14.4 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Nucleotid_trans PF03407.16 VDK87029.1 - 0.046 13.7 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase BPL_LplA_LipB PF03099.19 VDK87036.1 - 3.1e-08 33.6 0.0 5.5e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family MRP-S32 PF10210.9 VDK87037.1 - 5.9e-17 62.0 0.0 7.6e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S32 Leo1 PF04004.13 VDK87038.1 - 1.6e-47 161.4 0.0 1.6e-47 161.4 0.0 2.4 3 0 0 3 3 3 1 Leo1-like protein SicP-binding PF09119.10 VDK87038.1 - 0.012 15.6 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 SicP binding E2F_TDP PF02319.20 VDK87039.1 - 1.4e-23 82.7 0.2 3.1e-23 81.6 0.2 1.6 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain E2F_CC-MB PF16421.5 VDK87039.1 - 4e-23 81.6 0.0 7.8e-23 80.7 0.0 1.5 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain NYD-SP12_N PF15015.6 VDK87039.1 - 0.0019 16.7 0.1 0.0026 16.2 0.1 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal DUF2250 PF10007.9 VDK87039.1 - 0.2 11.8 0.1 0.2 11.8 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) TMF_DNA_bd PF12329.8 VDK87039.1 - 0.39 10.8 8.7 11 6.1 0.1 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SNAP PF14938.6 VDK87041.1 - 3.9e-90 302.1 20.4 5.6e-85 285.2 14.4 2.2 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 VDK87041.1 - 9.5e-07 29.0 7.0 0.0057 16.9 0.5 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87041.1 - 0.014 15.6 7.4 0.29 11.5 0.1 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK87041.1 - 0.015 15.3 11.2 7.9 6.8 0.2 5.5 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK87041.1 - 0.015 15.8 3.8 2.6 8.6 0.0 4.0 2 1 2 4 4 4 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 VDK87041.1 - 0.018 15.5 0.9 0.018 15.5 0.9 4.3 4 1 0 4 4 4 0 Zinc finger, C2H2 type TPR_10 PF13374.6 VDK87041.1 - 0.019 14.8 2.6 31 4.6 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2076 PF09849.9 VDK87041.1 - 0.054 13.5 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Spatacsin_C PF14649.6 VDK87041.1 - 0.14 11.3 8.1 0.24 10.5 5.1 2.6 2 1 1 3 3 3 0 Spatacsin C-terminus ANAPC3 PF12895.7 VDK87041.1 - 0.37 11.0 10.7 0.51 10.6 0.9 3.7 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 VDK87041.1 - 1.7 8.6 13.8 30 4.6 0.2 5.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 VDK87041.1 - 7.5 6.9 19.1 2.5 8.4 0.2 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 VDK87041.1 - 8 6.6 9.7 3.8 7.7 0.2 3.8 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 VDK87042.1 - 2.9e-09 37.0 1.7 0.065 14.1 0.0 5.7 4 2 2 6 6 6 4 Tetratricopeptide repeat Suf PF05843.14 VDK87042.1 - 4e-06 27.0 9.4 0.00045 20.3 0.0 2.7 3 0 0 3 3 3 2 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 VDK87042.1 - 2.4e-05 23.6 4.5 0.00044 19.5 1.6 3.9 2 2 1 3 3 3 2 NRDE-2, necessary for RNA interference TPR_15 PF13429.6 VDK87042.1 - 0.0011 18.2 0.1 0.75 9.0 0.0 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 VDK87042.1 - 0.0014 18.6 9.2 0.47 10.4 0.6 4.1 3 1 1 4 4 4 2 Mad3/BUB1 homology region 1 HAT PF02184.16 VDK87042.1 - 0.0026 17.7 17.6 0.35 10.9 0.1 5.4 5 1 0 5 5 5 3 HAT (Half-A-TPR) repeat TPR_6 PF13174.6 VDK87042.1 - 0.043 14.5 0.2 3.7 8.4 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Curto_V2 PF07325.11 VDK87042.1 - 0.075 12.9 0.1 0.4 10.5 0.0 2.2 1 1 1 2 2 2 0 Curtovirus V2 protein Transformer PF06495.11 VDK87042.1 - 0.13 12.4 19.2 0.062 13.4 14.8 2.4 2 0 0 2 2 2 0 Fruit fly transformer protein TP2 PF01254.18 VDK87042.1 - 1.3 9.7 17.9 2.9 8.5 17.9 1.6 1 0 0 1 1 1 0 Nuclear transition protein 2 zf-C2H2 PF00096.26 VDK87046.1 - 2e-14 53.1 27.4 2.2e-05 24.7 2.3 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK87046.1 - 2.7e-12 46.5 25.1 4.9e-07 29.9 2.9 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK87046.1 - 3.5e-10 39.8 23.3 0.00093 19.8 3.6 3.3 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDK87046.1 - 2.3e-06 27.8 12.1 0.01 16.1 0.3 3.3 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK87046.1 - 0.0074 16.7 13.2 0.1 13.0 1.2 3.5 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-BED PF02892.15 VDK87046.1 - 0.0078 16.2 16.3 0.32 11.0 2.0 3.0 2 1 0 2 2 2 2 BED zinc finger zf-C2H2_8 PF15909.5 VDK87046.1 - 0.017 15.4 5.8 0.027 14.8 5.8 1.3 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 VDK87046.1 - 0.037 14.0 22.2 0.48 10.5 3.8 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 VDK87046.1 - 0.11 12.4 1.2 0.11 12.4 1.2 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type PyrI_C PF02748.15 VDK87046.1 - 0.65 9.9 4.1 6.9 6.7 0.3 2.6 2 1 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain XPA_N PF01286.18 VDK87046.1 - 0.95 9.6 4.0 5 7.2 0.1 3.0 3 0 0 3 3 3 0 XPA protein N-terminal FOXP-CC PF16159.5 VDK87046.1 - 3.3 8.4 9.4 0.77 10.4 0.9 3.1 1 1 2 3 3 3 0 FOXP coiled-coil domain zf-LYAR PF08790.11 VDK87046.1 - 6.4 6.8 8.2 20 5.2 0.2 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Ribosomal_S19e PF01090.19 VDK87047.1 - 1.8e-57 192.8 0.3 2.1e-57 192.7 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e IF3_C PF00707.22 VDK87047.1 - 0.011 15.7 0.6 2.3 8.2 0.2 2.7 2 1 1 3 3 3 0 Translation initiation factor IF-3, C-terminal domain GntR PF00392.21 VDK87047.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Carboxyl_trans PF01039.22 VDK87050.1 - 1.9e-143 478.7 0.0 2.6e-143 478.3 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain ACC_central PF08326.12 VDK87050.1 - 5.4e-70 236.5 10.3 9.7e-46 156.3 1.2 2.1 2 0 0 2 2 2 2 Acetyl-CoA carboxylase, central region Biotin_lipoyl PF00364.22 VDK87050.1 - 5.5e-05 22.9 0.0 0.00013 21.7 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_carb_C PF02785.19 VDK87050.1 - 0.00082 19.5 0.0 0.0074 16.4 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain zf-C3HC4_2 PF13923.6 VDK87052.1 - 1.1e-08 34.8 9.6 1.1e-08 34.8 9.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 VDK87052.1 - 2.5e-06 27.2 10.8 7.4e-06 25.7 10.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RAWUL PF16207.5 VDK87052.1 - 2.9e-06 27.9 0.0 8.7e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 RAWUL domain RING finger- and WD40-associated ubiquitin-like zf-C3HC4_3 PF13920.6 VDK87052.1 - 1.1e-05 25.2 11.0 2.5e-05 24.0 11.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK87052.1 - 3.2e-05 24.2 10.8 3.2e-05 24.2 10.8 2.1 3 0 0 3 3 1 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK87052.1 - 5.1e-05 23.2 6.0 0.00019 21.4 6.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 VDK87052.1 - 0.00051 19.9 12.0 0.0014 18.5 12.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK87052.1 - 0.0065 16.3 9.9 0.016 15.0 9.9 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 VDK87052.1 - 0.016 15.0 3.0 0.044 13.7 3.0 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 VDK87052.1 - 0.058 13.2 5.4 0.18 11.6 5.4 1.9 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 VDK87052.1 - 0.098 13.0 9.2 0.32 11.3 9.2 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 VDK87052.1 - 0.26 11.5 7.2 0.68 10.1 7.2 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 VDK87052.1 - 0.42 10.4 5.1 0.85 9.4 5.1 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_4 PF14570.6 VDK87052.1 - 0.44 10.4 7.7 1 9.2 7.7 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 VDK87052.1 - 1.7 8.6 6.4 6.4 6.8 6.4 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK87052.1 - 4.3 7.5 9.4 9.6 6.3 7.0 2.3 2 1 1 3 3 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Glyco_hydro_98C PF08307.11 VDK87055.1 - 0.047 13.2 0.1 0.061 12.8 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 C-terminal domain LUC7 PF03194.15 VDK87056.1 - 0.07 12.8 0.8 0.095 12.3 0.8 1.1 1 0 0 1 1 1 0 LUC7 N_terminus C2-set PF05790.15 VDK87056.1 - 0.088 13.0 0.2 0.15 12.3 0.2 1.3 1 0 0 1 1 1 0 Immunoglobulin C2-set domain TPR_2 PF07719.17 VDK87057.1 - 3.3e-27 92.4 24.6 3.1e-05 23.8 0.2 10.2 11 1 1 12 12 11 6 Tetratricopeptide repeat TPR_1 PF00515.28 VDK87057.1 - 9.2e-27 91.7 29.0 2.1e-07 30.5 0.1 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 VDK87057.1 - 6.3e-24 82.2 14.0 0.00018 21.3 0.0 10.0 8 2 2 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 VDK87057.1 - 2.9e-22 78.8 16.6 9.7e-06 25.8 0.0 7.9 3 3 5 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87057.1 - 4.8e-19 66.9 32.5 0.0013 18.8 0.3 9.7 10 1 0 10 10 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 VDK87057.1 - 2.8e-17 61.9 0.4 0.0082 16.9 0.0 6.8 5 2 2 7 7 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 VDK87057.1 - 3.9e-15 56.1 16.3 0.012 16.1 0.0 6.7 4 2 3 7 7 7 4 Tetratricopeptide repeat TPR_6 PF13174.6 VDK87057.1 - 7.4e-15 54.5 15.8 0.0055 17.3 0.0 9.5 8 2 1 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 VDK87057.1 - 1.2e-14 54.6 2.6 2.3e-05 24.9 0.1 5.9 5 1 1 6 6 6 2 Tetratricopeptide repeat RPN7 PF10602.9 VDK87057.1 - 2.4e-12 46.9 0.1 9.5e-05 22.2 0.0 4.5 3 1 2 5 5 5 3 26S proteasome subunit RPN7 ANAPC3 PF12895.7 VDK87057.1 - 3.4e-11 43.2 14.6 5.4e-05 23.3 0.0 5.2 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 VDK87057.1 - 1e-10 41.1 34.1 9e-06 25.3 0.6 8.3 6 1 2 9 9 9 4 TPR repeat TPR_10 PF13374.6 VDK87057.1 - 5.9e-10 38.7 15.5 2.1 8.3 0.0 9.9 11 2 0 11 11 10 2 Tetratricopeptide repeat TPR_MalT PF17874.1 VDK87057.1 - 2.4e-09 37.1 0.2 0.0035 16.8 0.0 4.5 3 1 2 5 5 5 2 MalT-like TPR region TPR_17 PF13431.6 VDK87057.1 - 6.1e-06 26.2 16.7 0.12 12.8 0.0 7.8 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_21 PF09976.9 VDK87057.1 - 9.8e-06 25.4 4.8 0.00074 19.3 1.9 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain PPR PF01535.20 VDK87057.1 - 0.00025 21.1 1.4 2.5 8.5 0.0 5.6 6 0 0 6 6 4 1 PPR repeat TPR_9 PF13371.6 VDK87057.1 - 0.00046 20.3 0.1 0.5 10.6 0.1 4.0 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_5 PF12688.7 VDK87057.1 - 0.0024 18.1 0.2 16 5.7 0.0 4.2 5 0 0 5 5 4 0 Tetratrico peptide repeat HrpB1_HrpK PF09613.10 VDK87057.1 - 0.0062 16.2 0.1 0.5 10.0 0.1 3.3 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_15 PF13429.6 VDK87057.1 - 0.0082 15.4 9.0 0.48 9.6 0.8 4.0 2 1 1 3 3 3 1 Tetratricopeptide repeat PPR_2 PF13041.6 VDK87057.1 - 0.013 15.7 3.7 3.2 8.0 0.0 4.7 5 0 0 5 5 5 0 PPR repeat family Fis1_TPR_C PF14853.6 VDK87057.1 - 0.014 15.5 9.8 6.8 6.9 0.2 5.6 5 1 2 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat Foie-gras_1 PF11817.8 VDK87057.1 - 0.025 14.2 0.6 2.1 7.9 0.1 3.1 2 1 1 3 3 3 0 Foie gras liver health family 1 Sel1 PF08238.12 VDK87057.1 - 0.032 14.9 16.5 18 6.2 0.2 7.3 8 0 0 8 8 7 0 Sel1 repeat DUF2992 PF11208.8 VDK87057.1 - 0.054 13.8 0.2 0.12 12.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) TPR_4 PF07721.14 VDK87057.1 - 0.12 13.1 0.1 81 4.3 0.1 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 VDK87057.1 - 0.58 10.2 24.9 6.3 6.9 2.2 7.4 8 0 0 8 8 7 0 Tetratricopeptide repeat DUF4810 PF16068.5 VDK87057.1 - 1.9 9.1 4.5 1.3e+02 3.2 0.0 4.6 5 1 1 6 6 4 0 Domain of unknown function (DUF4810) Prefoldin_2 PF01920.20 VDK87058.1 - 1.8e-16 60.0 4.1 2.6e-16 59.5 4.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Vps39_1 PF10366.9 VDK87058.1 - 0.062 13.6 0.6 0.56 10.5 0.1 2.3 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 PRKCSH PF07915.13 VDK87059.1 - 8.5e-30 103.6 8.8 5.9e-14 52.8 0.1 2.5 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 VDK87059.1 - 5.7e-09 35.8 0.2 0.0021 17.8 0.0 2.5 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein Cnd2 PF05786.14 VDK87060.1 - 9.9e-09 34.4 7.3 1.3e-08 34.0 7.3 1.2 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 VDK87060.1 - 0.044 14.0 1.0 0.084 13.1 0.0 1.9 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal UBA PF00627.31 VDK87065.1 - 0.064 13.2 0.2 0.21 11.6 0.2 1.9 1 0 0 1 1 1 0 UBA/TS-N domain Pkinase PF00069.25 VDK87066.1 - 6.1e-67 225.8 0.1 1.2e-44 152.6 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87066.1 - 1.2e-30 106.7 0.0 4.8e-23 81.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK87066.1 - 0.00013 21.0 0.4 0.00021 20.3 0.4 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 VDK87066.1 - 0.00074 19.5 0.4 0.036 14.0 0.3 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 VDK87066.1 - 0.0027 17.1 1.0 0.0088 15.4 0.0 2.2 2 1 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 VDK87066.1 - 0.0028 16.5 0.0 0.0063 15.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK87066.1 - 0.0081 15.5 0.1 0.015 14.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 VDK87066.1 - 0.054 12.6 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_C PF00433.24 VDK87066.1 - 0.29 11.9 7.9 0.81 10.4 7.9 1.8 1 0 0 1 1 1 0 Protein kinase C terminal domain Shisa PF13908.6 VDK87069.1 - 0.017 15.3 0.3 0.022 15.0 0.3 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator LSR PF05624.14 VDK87069.1 - 0.62 10.1 5.6 1 9.4 5.6 1.2 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) Galactosyl_T PF01762.21 VDK87071.1 - 6.3e-37 127.3 2.6 8.5e-37 126.9 2.6 1.2 1 0 0 1 1 1 1 Galactosyltransferase DUF5361 PF17318.2 VDK87071.1 - 0.062 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5361) GCIP PF13324.6 VDK87075.1 - 0.0099 15.5 0.0 0.0099 15.5 0.0 1.1 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting MRP-63 PF14978.6 VDK87077.1 - 1.2e-06 29.1 5.9 0.00011 22.7 5.9 2.1 1 1 0 1 1 1 1 Mitochondrial ribosome protein 63 ALIX_LYPXL_bnd PF13949.6 VDK87082.1 - 0.14 11.5 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV RRM_1 PF00076.22 VDK87088.1 - 2.1e-12 46.6 0.1 3.9e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 VDK87089.1 - 1.4e-16 60.1 0.0 1.9e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_RNB PF08206.11 VDK87089.1 - 0.017 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease B OB domain CIA30 PF08547.12 VDK87091.1 - 6.2e-32 110.8 0.0 9.5e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) RNase_T PF00929.24 VDK87093.1 - 1.2e-08 35.6 0.0 3.1e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Exonuclease DUF1027 PF06265.11 VDK87093.1 - 0.13 12.2 0.5 0.43 10.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1027) Ric8 PF10165.9 VDK87095.1 - 3.7e-96 323.0 0.4 5.1e-96 322.5 0.4 1.2 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn QIL1 PF15884.5 VDK87096.1 - 0.00011 22.7 0.0 0.00014 22.3 0.0 1.2 1 0 0 1 1 1 1 MICOS complex subunit MIC13, QIL1 Bromodomain PF00439.25 VDK87097.1 - 3.9e-22 78.1 0.1 1.4e-21 76.3 0.1 1.9 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.31 VDK87097.1 - 3.5e-20 72.4 0.0 2.1e-19 69.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.6 VDK87097.1 - 1.9e-08 34.8 4.4 1.9e-08 34.8 4.4 3.9 5 0 0 5 5 5 1 Snf2-ATP coupling, chromatin remodelling complex Spb1_C PF07780.12 VDK87100.1 - 5.9e-60 202.5 20.0 7.3e-60 202.2 20.0 1.1 1 0 0 1 1 1 1 Spb1 C-terminal domain Thioredoxin_6 PF13848.6 VDK87101.1 - 1.8e-07 31.3 1.4 3.7e-07 30.2 0.5 2.1 2 1 0 2 2 2 1 Thioredoxin-like domain DUF2786 PF10979.8 VDK87101.1 - 0.12 12.3 0.1 0.27 11.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) DUF5099 PF17025.5 VDK87101.1 - 0.28 11.6 3.5 14 6.2 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5099) DUF19 PF01579.18 VDK87102.1 - 7.7e-15 55.0 70.6 5.2e-11 42.6 9.6 7.4 7 2 0 7 7 7 3 Domain of unknown function (DUF19) zf-RING-like PF08746.11 VDK87102.1 - 0.5 10.7 0.0 0.5 10.7 0.0 5.0 5 0 0 5 5 5 0 RING-like domain uDENN PF03456.18 VDK87105.1 - 0.0046 17.7 0.0 0.0062 17.3 0.0 1.2 1 0 0 1 1 1 1 uDENN domain ANF_receptor PF01094.28 VDK87107.1 - 1.2e-64 218.7 0.0 1.5e-64 218.3 0.0 1.2 1 0 0 1 1 1 1 Receptor family ligand binding region 7tm_3 PF00003.22 VDK87107.1 - 2.7e-49 168.0 15.9 5e-49 167.2 15.9 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Peripla_BP_6 PF13458.6 VDK87107.1 - 1.7e-10 41.1 0.0 2.5e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DUF5110 PF17137.4 VDK87108.1 - 0.43 10.9 0.1 0.43 10.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5110) BCAS3 PF12490.8 VDK87110.1 - 0.27 10.7 4.2 0.28 10.7 2.9 1.6 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 3 Mrpl_C PF18502.1 VDK87119.1 - 0.12 12.6 0.3 0.12 12.6 0.3 1.8 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain Hydrolase_3 PF08282.12 VDK87119.1 - 0.22 11.2 8.4 0.33 10.6 2.4 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase GTP_EFTU PF00009.27 VDK87120.1 - 3.4e-30 105.1 5.2 9.7e-24 84.0 0.7 2.5 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain IF-2 PF11987.8 VDK87120.1 - 4.8e-24 84.5 0.1 1.9e-23 82.6 0.0 2.0 2 0 0 2 2 2 1 Translation-initiation factor 2 Ras PF00071.22 VDK87120.1 - 2.2e-06 27.3 0.7 3.5e-05 23.5 0.2 2.5 2 1 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 VDK87120.1 - 2.5e-05 24.3 0.0 0.00054 20.0 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 VDK87120.1 - 2.9e-05 23.9 0.2 6.1e-05 22.8 0.2 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 VDK87120.1 - 0.00094 18.7 0.0 0.0024 17.3 0.0 1.7 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 VDK87120.1 - 0.002 17.6 0.3 0.002 17.6 0.3 2.4 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 VDK87120.1 - 0.0023 17.9 0.0 0.19 11.7 0.1 2.7 2 0 0 2 2 2 1 RsgA GTPase IF2_N PF04760.15 VDK87120.1 - 0.015 15.1 0.3 0.038 13.8 0.3 1.7 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Roc PF08477.13 VDK87120.1 - 0.017 15.3 0.1 0.18 12.0 0.1 2.6 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 VDK87120.1 - 0.028 14.4 1.1 0.27 11.3 0.2 2.5 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 VDK87120.1 - 0.057 13.5 0.7 26 4.8 0.1 3.2 2 1 1 3 3 3 0 Dynamin family FeoB_N PF02421.18 VDK87120.1 - 0.1 12.1 3.4 0.16 11.5 1.0 2.5 2 1 0 2 2 2 0 Ferrous iron transport protein B SIS_2 PF13580.6 VDK87120.1 - 0.14 12.1 0.3 0.37 10.8 0.3 1.7 1 0 0 1 1 1 0 SIS domain AAA_23 PF13476.6 VDK87120.1 - 0.15 12.5 4.9 1.1 9.8 3.8 2.7 2 1 0 2 2 2 0 AAA domain DUF4600 PF15372.6 VDK87120.1 - 6.9 7.1 12.9 8.8 6.8 6.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) PAS_3 PF08447.12 VDK87122.1 - 3.3e-16 59.4 0.3 3.9e-12 46.3 0.2 2.6 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 VDK87122.1 - 1.2e-15 57.6 1.8 8.3e-15 54.9 0.6 2.4 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 VDK87122.1 - 1e-06 28.9 0.0 0.0042 17.3 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 VDK87122.1 - 1.7e-06 28.0 0.0 0.072 13.1 0.0 2.4 2 0 0 2 2 2 2 PAS fold CH PF00307.31 VDK87128.1 - 2e-21 76.2 0.2 2.7e-21 75.8 0.2 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 VDK87128.1 - 3.2e-09 36.2 4.8 5.9e-09 35.4 4.8 1.5 1 0 0 1 1 1 1 Calponin family repeat CAMSAP_CH PF11971.8 VDK87128.1 - 0.00022 21.0 0.0 0.00033 20.4 0.0 1.3 1 0 0 1 1 1 1 CAMSAP CH domain Hormone_recep PF00104.30 VDK87129.1 - 1.9e-34 119.1 0.1 4.1e-34 118.0 0.1 1.5 1 1 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor zf-C4 PF00105.18 VDK87129.1 - 2.7e-28 98.2 16.7 2.7e-28 98.2 16.7 2.3 2 0 0 2 2 2 1 Zinc finger, C4 type (two domains) OMP_b-brl PF13505.6 VDK87130.1 - 0.56 10.3 6.5 0.65 10.1 6.5 1.2 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain Ribosomal_60s PF00428.19 VDK87130.1 - 3.8 8.2 15.5 5.5 7.7 15.5 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Mito_fiss_reg PF05308.11 VDK87132.1 - 0.12 12.5 8.6 0.12 12.4 8.6 1.0 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 VDK87132.1 - 1.7 8.7 16.1 1.9 8.5 16.1 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 VDK87132.1 - 8.5 5.8 13.5 8.3 5.8 13.5 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal TPR_2 PF07719.17 VDK87134.1 - 0.0011 19.0 0.1 0.098 12.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87134.1 - 0.0031 17.6 0.0 0.017 15.3 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDK87134.1 - 0.0067 16.2 0.1 0.14 12.0 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 VDK87134.1 - 0.067 13.6 0.0 7.5 7.2 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat HMG_box PF00505.19 VDK87136.1 - 1.8e-17 63.5 1.2 4e-17 62.4 1.2 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK87136.1 - 1.9e-08 34.8 1.4 5.3e-08 33.3 1.4 1.8 1 0 0 1 1 1 1 HMG-box domain SAM_1 PF00536.30 VDK87137.1 - 2.5e-24 85.5 0.1 3.9e-11 43.2 0.1 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 VDK87137.1 - 4e-19 68.5 0.1 9e-11 41.7 0.0 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Caskin-tail PF16632.5 VDK87137.1 - 1.6e-05 25.3 1.3 3.6e-05 24.1 0.1 2.3 3 0 0 3 3 3 1 C-terminal region of Caskin RabGAP-TBC PF00566.18 VDK87144.1 - 9.5e-52 175.8 3.2 1.4e-51 175.2 3.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ELMO_CED12 PF04727.13 VDK87144.1 - 0.011 15.9 0.1 0.019 15.1 0.1 1.5 1 1 0 1 1 1 0 ELMO/CED-12 family DUF4864 PF16156.5 VDK87144.1 - 0.018 15.7 0.4 0.053 14.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4864) Cullin_binding PF03556.15 VDK87144.1 - 0.024 15.0 0.8 0.064 13.7 0.1 2.0 2 0 0 2 2 2 0 Cullin binding zf-C4_Topoisom PF01396.19 VDK87147.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Topoisomerase DNA binding C4 zinc finger DUF1746 PF08508.10 VDK87147.1 - 0.027 14.8 0.9 1.1 9.7 0.2 2.1 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1746) LBP_BPI_CETP_C PF02886.17 VDK87148.1 - 0.012 15.0 0.0 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 VDK87149.1 - 4.3e-12 46.0 0.8 9.4e-12 44.8 0.8 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain LBP_BPI_CETP_C PF02886.17 VDK87149.1 - 4.7e-05 23.0 0.2 0.0019 17.7 0.1 2.8 2 1 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain Pro_isomerase PF00160.21 VDK87150.1 - 1.6e-37 129.2 0.0 1.8e-37 129.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cofilin_ADF PF00241.20 VDK87151.1 - 4.5e-58 194.3 5.4 1.6e-30 105.4 0.3 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DUF2013 PF09431.10 VDK87155.1 - 2.9e-09 37.2 3.0 6.3e-09 36.1 3.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) SPACA7 PF15307.6 VDK87155.1 - 0.12 12.7 0.5 0.4 11.0 0.1 2.0 2 0 0 2 2 2 0 Sperm acrosome-associated protein 7 zf-CCCH_4 PF18044.1 VDK87156.1 - 2.1e-21 75.2 30.4 8.3e-07 28.7 0.6 5.1 4 0 0 4 4 4 4 CCCH-type zinc finger zf_CCCH_4 PF18345.1 VDK87156.1 - 4.2e-18 64.8 34.8 8.3e-06 25.7 3.8 5.3 5 0 0 5 5 5 4 Zinc finger domain zf-CCCH PF00642.24 VDK87156.1 - 5.2e-17 61.3 26.3 2.7e-06 27.1 0.5 4.8 4 0 0 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 VDK87156.1 - 2e-13 51.0 14.4 0.0096 16.6 0.1 4.4 3 1 1 4 4 4 4 Torus domain zf-CCCH_2 PF14608.6 VDK87156.1 - 1.5e-07 31.6 31.5 0.00069 20.0 2.2 5.4 5 0 0 5 5 5 3 RNA-binding, Nab2-type zinc finger zf-RING_2 PF13639.6 VDK87156.1 - 4.3e-07 30.2 10.9 4.3e-07 30.2 10.9 4.0 4 2 1 5 5 3 1 Ring finger domain zf-C3HC4 PF00097.25 VDK87156.1 - 2.4e-06 27.3 9.9 2.4e-06 27.3 9.9 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK87156.1 - 5.5e-05 23.1 6.2 5.5e-05 23.1 6.2 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 VDK87156.1 - 0.00012 21.8 9.1 0.00012 21.8 9.1 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK87156.1 - 0.0059 16.5 10.3 0.0059 16.5 10.3 2.8 3 0 0 3 3 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 VDK87156.1 - 0.02 14.7 10.7 0.02 14.7 10.7 3.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PAM2 PF07145.15 VDK87156.1 - 0.056 13.1 0.0 0.092 12.5 0.0 1.4 1 0 0 1 1 1 0 Ataxin-2 C-terminal region zf-C3HC4_4 PF15227.6 VDK87156.1 - 0.19 11.9 9.5 0.061 13.5 5.4 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 VDK87156.1 - 0.67 9.9 17.9 0.047 13.6 7.6 3.6 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 VDK87156.1 - 1.4 8.8 15.3 0.043 13.6 8.1 2.3 3 0 0 3 3 3 0 RING-like zinc finger Baculo_RING PF05883.11 VDK87156.1 - 2 8.4 10.3 0.14 12.1 5.1 1.7 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain zf-CCCH_3 PF15663.5 VDK87156.1 - 5.1 7.4 27.6 0.05 13.8 3.9 3.7 2 1 0 3 3 3 0 Zinc-finger containing family Ntox16 PF15523.6 VDK87158.1 - 0.0058 16.8 0.5 0.0069 16.6 0.5 1.1 1 0 0 1 1 1 1 Novel toxin 16 DUF3338 PF11819.8 VDK87160.1 - 5.9e-31 107.3 6.9 1.5e-30 105.9 6.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) DUF4564 PF15169.6 VDK87160.1 - 0.037 13.7 0.9 0.076 12.7 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4564) DUF3338 PF11819.8 VDK87161.1 - 6.6e-31 107.1 7.2 1.8e-30 105.7 7.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3338) DUF4564 PF15169.6 VDK87161.1 - 0.033 13.9 0.9 0.07 12.9 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4564) Med30 PF11315.8 VDK87161.1 - 6.9 6.9 7.9 1 9.6 3.4 1.9 2 0 0 2 2 2 0 Mediator complex subunit 30 VWA_2 PF13519.6 VDK87165.1 - 1.6e-16 60.9 0.0 2.5e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 VDK87165.1 - 0.00035 20.9 0.0 0.00061 20.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Ku_N PF03731.15 VDK87165.1 - 0.25 11.1 0.1 0.38 10.5 0.1 1.2 1 0 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain Importin_rep_5 PF18816.1 VDK87165.1 - 0.25 11.7 0.4 24 5.3 0.0 2.6 2 0 0 2 2 2 0 Importin repeat Med14 PF08638.11 VDK87166.1 - 1.8e-53 180.8 0.0 4.5e-53 179.5 0.0 1.7 1 0 0 1 1 1 1 Mediator complex subunit MED14 DDT PF02791.17 VDK87166.1 - 0.71 10.2 2.9 0.92 9.9 0.1 2.5 3 0 0 3 3 3 0 DDT domain Cg6151-P PF10233.9 VDK87167.1 - 7.2e-29 100.4 10.9 8.7e-29 100.1 10.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P TMEM72 PF16054.5 VDK87167.1 - 0.0023 17.6 0.9 0.0031 17.2 0.9 1.2 1 0 0 1 1 1 1 Transmembrane protein family 72 EI24 PF07264.11 VDK87167.1 - 0.031 14.5 7.3 0.038 14.2 7.3 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) TMEM43 PF07787.12 VDK87167.1 - 0.27 10.6 1.6 0.42 9.9 1.6 1.2 1 0 0 1 1 1 0 Transmembrane protein 43 Deltameth_res PF16020.5 VDK87167.1 - 6.6 6.7 5.8 11 5.9 0.1 2.7 2 1 0 2 2 2 0 Deltamethrin resistance DUF5326 PF17260.2 VDK87167.1 - 6.9 6.9 10.8 37 4.5 10.8 2.2 1 1 0 1 1 1 0 Family of unknown function (DUF5326) TIL PF01826.17 VDK87173.1 - 2.3e-29 101.4 173.6 8.4e-09 35.6 15.5 9.5 10 1 0 10 10 10 6 Trypsin Inhibitor like cysteine rich domain Sod_Cu PF00080.20 VDK87173.1 - 1.1e-11 45.1 0.0 2.7e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) WAP PF00095.21 VDK87173.1 - 8.1e-05 22.9 11.2 8.1e-05 22.9 11.2 10.7 8 3 1 9 9 9 3 WAP-type (Whey Acidic Protein) 'four-disulfide core' MFS_1 PF07690.16 VDK87174.1 - 2.2e-13 49.8 37.2 5.6e-10 38.7 23.5 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Metallophos PF00149.28 VDK87175.1 - 1.5e-40 139.9 0.1 1.9e-40 139.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK87175.1 - 2.3e-22 79.2 0.4 4.9e-22 78.1 0.4 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain 7TM_GPCR_Srw PF10324.9 VDK87179.1 - 5.2e-28 98.2 3.2 7.1e-28 97.8 3.2 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 VDK87179.1 - 0.0065 15.8 1.6 0.013 14.8 1.6 1.6 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) UPF0542 PF15086.6 VDK87179.1 - 0.015 15.2 0.1 0.17 11.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 DUF4598 PF15370.6 VDK87182.1 - 0.0018 18.7 4.4 0.0039 17.6 4.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4598) PPR_2 PF13041.6 VDK87183.1 - 4.4e-12 46.0 2.2 0.0004 20.5 0.1 3.8 1 1 2 3 3 3 3 PPR repeat family PPR_3 PF13812.6 VDK87183.1 - 3.3e-06 27.1 0.3 0.00013 22.0 0.3 2.6 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.4 VDK87183.1 - 0.00044 19.7 0.4 0.0039 16.6 0.5 2.4 2 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 VDK87183.1 - 0.0097 16.1 1.9 4.3 7.8 1.0 4.5 3 1 0 3 3 3 1 PPR repeat PPR_1 PF12854.7 VDK87183.1 - 0.014 15.1 0.4 8.9 6.1 0.0 3.8 4 1 0 4 4 4 0 PPR repeat Metallophos PF00149.28 VDK87189.1 - 4.2e-34 118.9 0.0 5.2e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 VDK87189.1 - 0.0025 18.1 0.0 0.0039 17.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TPR_14 PF13428.6 VDK87190.1 - 1.1e-16 60.1 10.2 0.16 12.9 0.0 12.0 7 3 5 12 12 11 2 Tetratricopeptide repeat Suf PF05843.14 VDK87190.1 - 3.8e-08 33.7 18.3 0.0061 16.6 0.6 5.7 4 1 1 6 6 6 3 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 VDK87190.1 - 1e-07 32.0 15.3 0.00032 20.7 0.5 6.4 4 3 1 5 5 5 3 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 VDK87190.1 - 5.5e-07 29.2 12.0 0.01 15.9 0.1 7.0 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87190.1 - 6.5e-07 29.1 14.5 0.79 10.1 0.1 8.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 VDK87190.1 - 7.6e-06 25.3 3.2 0.34 10.1 0.0 5.8 3 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK87190.1 - 4.9e-05 23.5 6.5 0.69 10.2 0.1 6.0 6 1 0 6 6 6 1 Tetratricopeptide repeat NRDE-2 PF08424.10 VDK87190.1 - 5.5e-05 22.5 6.8 0.0024 17.0 0.1 4.7 2 2 1 3 3 3 1 NRDE-2, necessary for RNA interference RPN7 PF10602.9 VDK87190.1 - 0.00023 20.9 1.2 0.47 10.1 0.0 3.5 3 1 1 4 4 4 2 26S proteasome subunit RPN7 TPR_19 PF14559.6 VDK87190.1 - 0.00075 20.0 2.6 14 6.3 0.0 7.1 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDK87190.1 - 0.00075 19.7 9.5 3.7 8.2 0.0 6.8 6 1 1 7 7 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 VDK87190.1 - 0.0029 17.5 1.5 0.084 12.9 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK87190.1 - 0.004 17.8 4.3 1.6 9.4 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 VDK87190.1 - 0.05 13.5 3.5 4.4 7.3 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK87190.1 - 0.068 13.0 8.4 1 9.3 0.1 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK87190.1 - 0.07 13.8 3.7 39 5.2 0.0 5.1 4 0 0 4 4 3 0 Tetratricopeptide repeat PPR PF01535.20 VDK87190.1 - 0.098 12.9 0.1 11 6.5 0.0 4.3 5 0 0 5 5 3 0 PPR repeat HAT PF02184.16 VDK87190.1 - 5.1 7.2 20.8 3.8 7.6 0.1 7.5 8 1 0 8 8 7 0 HAT (Half-A-TPR) repeat UPF0231 PF06062.11 VDK87191.1 - 0.008 16.4 0.5 0.99 9.7 0.1 2.3 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0231) Sporozoite_P67 PF05642.11 VDK87193.1 - 0.035 12.2 0.1 0.036 12.2 0.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Mucin PF01456.17 VDK87193.1 - 0.34 10.9 25.4 0.53 10.3 25.4 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 VDK87193.1 - 0.44 8.6 8.3 0.59 8.2 8.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mito_carr PF00153.27 VDK87194.1 - 7.4e-46 154.0 0.4 1.4e-17 63.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Peptidase_C48 PF02902.19 VDK87195.1 - 5.4e-47 160.4 1.9 5.7e-47 160.3 0.5 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain Prp19 PF08606.11 VDK87196.1 - 2.7e-31 107.4 2.1 6.1e-31 106.2 2.1 1.7 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 VDK87196.1 - 4.9e-28 96.8 10.4 1.7e-06 28.6 0.0 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK87196.1 - 1.5e-14 54.0 2.0 0.0017 18.6 0.0 5.4 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain HPS3_N PF14761.6 VDK87196.1 - 8.4e-06 25.5 0.0 0.16 11.5 0.0 2.5 2 1 0 2 2 2 2 Hermansky-Pudlak syndrome 3 eIF2A PF08662.11 VDK87196.1 - 2.3e-05 24.4 0.2 0.049 13.5 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 VDK87196.1 - 4e-05 22.7 0.4 0.44 9.5 0.0 3.9 1 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein U-box PF04564.15 VDK87196.1 - 0.0012 18.9 0.0 0.0026 17.9 0.0 1.5 1 0 0 1 1 1 1 U-box domain Cytochrom_D1 PF02239.16 VDK87196.1 - 0.0037 15.9 0.1 0.058 11.9 0.0 2.3 2 1 0 2 2 2 1 Cytochrome D1 heme domain zf-Nse PF11789.8 VDK87196.1 - 0.0051 16.6 0.1 0.025 14.4 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Golgin_A5 PF09787.9 VDK87196.1 - 0.0064 16.0 1.0 0.0094 15.5 1.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 Nup160 PF11715.8 VDK87196.1 - 0.0084 14.8 0.2 1.1 7.9 0.0 2.4 3 0 0 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 VDK87196.1 - 0.084 11.6 0.2 0.62 8.7 0.1 2.0 2 0 0 2 2 2 0 Nup133 N terminal like Hira PF07569.11 VDK87196.1 - 0.11 12.2 0.8 1.9 8.2 0.1 2.9 3 0 0 3 3 3 0 TUP1-like enhancer of split DUF3372 PF11852.8 VDK87196.1 - 0.13 11.7 0.2 0.3 10.5 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3372) TPR_MLP1_2 PF07926.12 VDK87196.1 - 0.77 9.8 3.9 0.7 10.0 2.0 1.8 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein C1_1 PF00130.22 VDK87197.1 - 8.7e-09 35.1 10.8 1.7e-08 34.2 10.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 VDK87197.1 - 0.00012 22.2 6.6 0.00016 21.8 6.6 1.3 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon Prok-RING_1 PF14446.6 VDK87197.1 - 0.0013 18.6 6.9 0.0029 17.5 6.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 Zf_RING PF16744.5 VDK87197.1 - 0.01 15.9 5.7 0.021 14.9 5.7 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger C1_2 PF03107.16 VDK87197.1 - 0.017 15.5 8.9 0.055 13.8 8.9 1.9 1 0 0 1 1 1 0 C1 domain DEC-1_N PF04625.13 VDK87197.1 - 0.14 11.1 0.1 0.2 10.6 0.1 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Adap_comp_sub PF00928.21 VDK87200.1 - 3.9e-28 98.5 2.0 6.1e-28 97.9 2.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 VDK87200.1 - 3e-05 24.0 0.1 5.2e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Rootletin PF15035.6 VDK87203.1 - 4.2e-05 23.6 19.0 0.00093 19.3 13.4 2.1 1 1 1 2 2 2 2 Ciliary rootlet component, centrosome cohesion Ion_trans_2 PF07885.16 VDK87205.1 - 1.7e-25 88.8 31.0 8.6e-14 51.3 9.5 4.1 4 1 0 4 4 4 3 Ion channel MYEOV2 PF15004.6 VDK87206.1 - 0.024 15.1 0.1 0.27 11.7 0.0 2.1 2 0 0 2 2 2 0 Myeloma-overexpressed-like Moulting_cycle PF04870.16 VDK87210.1 - 5.3e-60 203.5 2.7 3.8e-57 194.1 0.0 2.0 1 1 1 2 2 2 2 Moulting cycle DUF1294 PF06961.13 VDK87210.1 - 0.066 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) Oxidored_nitro PF00148.19 VDK87210.1 - 0.2 10.3 0.0 2.8 6.6 0.0 2.0 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase Na_Ca_ex PF01699.24 VDK87213.1 - 4.6e-51 172.7 22.8 2.6e-26 92.4 10.0 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Calx-beta PF03160.14 VDK87213.1 - 1.3e-46 156.9 6.1 1.6e-25 89.2 0.8 2.7 2 0 0 2 2 2 2 Calx-beta domain Na_Ca_ex_C PF16494.5 VDK87213.1 - 9.8e-29 100.4 3.3 1.8e-28 99.5 3.3 1.5 1 0 0 1 1 1 1 C-terminal extension of sodium/calcium exchanger domain DUF4843 PF16132.5 VDK87213.1 - 0.024 14.2 0.0 5.4 6.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4843) GATA PF00320.27 VDK87219.1 - 1.9e-14 52.9 3.8 4.1e-14 51.9 3.8 1.6 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 VDK87219.1 - 0.023 14.2 0.5 0.046 13.2 0.5 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding ArfGap PF01412.18 VDK87219.1 - 0.062 13.4 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Prim_Zn_Ribbon PF08273.12 VDK87219.1 - 0.12 12.7 1.7 0.31 11.3 1.7 1.7 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase Arm PF00514.23 VDK87223.1 - 3e-28 97.0 8.4 1.8e-07 30.9 0.0 6.3 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 VDK87223.1 - 1.6e-05 25.2 0.1 0.34 11.3 0.0 2.7 2 1 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 VDK87223.1 - 4e-05 24.0 2.4 0.27 11.8 0.0 4.1 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 VDK87223.1 - 0.00032 20.7 3.1 1.1 9.7 0.0 3.8 3 0 0 3 3 3 2 HEAT repeat Atx10homo_assoc PF09759.9 VDK87223.1 - 0.0028 17.6 1.5 0.3 11.1 0.0 2.9 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 VDK87223.1 - 0.0053 16.3 0.2 1.4 8.3 0.0 2.8 2 1 0 2 2 2 2 Armadillo-like RRM_1 PF00076.22 VDK87228.1 - 2.8e-17 62.3 0.0 5e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK87228.1 - 0.00057 20.0 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 VDK87228.1 - 0.016 15.2 0.1 0.035 14.1 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF2229 PF09989.9 VDK87228.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) PHM7_cyt PF14703.6 VDK87228.1 - 0.35 11.1 0.1 0.35 11.1 0.1 2.0 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter CITED PF04487.12 VDK87228.1 - 0.67 10.0 4.8 1.3 9.1 4.8 1.4 1 0 0 1 1 1 0 CITED LBP_BPI_CETP_C PF02886.17 VDK87232.1 - 0.049 13.1 0.1 0.099 12.1 0.1 1.5 1 0 0 1 1 1 0 LBP / BPI / CETP family, C-terminal domain Pkinase PF00069.25 VDK87233.1 - 2.4e-21 76.3 0.0 3.5e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 VDK87233.1 - 8.2e-10 38.0 0.0 1.3e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 VDK87233.1 - 5e-09 35.8 0.0 1.7e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK87233.1 - 0.036 14.0 0.2 0.15 12.0 0.1 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 VDK87233.1 - 0.07 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Brix PF04427.18 VDK87234.1 - 1.4e-25 90.5 0.4 1.4e-25 90.5 0.4 1.5 2 0 0 2 2 2 1 Brix domain Folate_carrier PF01770.18 VDK87235.1 - 5.4e-101 338.3 31.1 7.3e-101 337.9 31.1 1.1 1 0 0 1 1 1 1 Reduced folate carrier Sec23_helical PF04815.15 VDK87235.1 - 0.13 12.1 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 Sec23/Sec24 helical domain PLAC8 PF04749.17 VDK87235.1 - 0.91 10.6 3.5 0.74 10.8 1.1 2.1 2 0 0 2 2 2 0 PLAC8 family TSP_1 PF00090.19 VDK87239.1 - 2.6e-06 27.6 9.1 4.4e-06 26.8 9.1 1.4 1 0 0 1 1 1 1 Thrombospondin type 1 domain VOMI PF03762.17 VDK87239.1 - 0.0073 16.5 0.5 0.01 16.0 0.5 1.3 1 0 0 1 1 1 1 Vitelline membrane outer layer protein I (VOMI) Sec2p PF06428.11 VDK87240.1 - 0.53 10.3 2.9 0.4 10.7 0.3 2.2 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Glyco_trans_1_4 PF13692.6 VDK87245.1 - 1.6e-08 35.1 0.0 2.8e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 VDK87245.1 - 1.8e-06 27.6 0.0 3.5e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 VDK87245.1 - 0.0038 17.6 0.0 0.013 15.8 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 GTP_EFTU PF00009.27 VDK87249.1 - 1.6e-30 106.2 0.1 1.6e-30 106.2 0.1 3.8 3 2 0 3 3 3 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 VDK87249.1 - 1.5e-19 70.0 0.1 6.2e-19 68.1 0.1 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 VDK87249.1 - 1e-14 54.2 0.0 4.9e-14 52.0 0.0 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 VDK87249.1 - 1.3e-11 44.7 10.1 1.2e-08 35.2 0.2 3.5 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 VDK87249.1 - 1.4e-06 28.4 0.3 9.7e-06 25.7 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDK87249.1 - 0.00011 22.2 3.4 0.33 10.9 0.1 3.5 2 1 1 3 3 3 2 RsgA GTPase YL1 PF05764.13 VDK87249.1 - 0.0077 16.4 8.2 0.0077 16.4 8.2 4.3 2 1 1 3 3 3 1 YL1 nuclear protein AMP-binding PF00501.28 VDK87254.1 - 1.3e-46 159.1 0.0 1.7e-46 158.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme EF-hand_3 PF09069.11 VDK87256.1 - 1.4e-15 57.5 0.0 4.3e-15 55.9 0.0 1.9 1 0 0 1 1 1 1 EF-hand ZZ PF00569.17 VDK87256.1 - 2e-10 40.3 8.8 4.3e-10 39.2 8.8 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type C1_2 PF03107.16 VDK87256.1 - 8.4e-05 22.8 5.6 0.00016 21.9 5.6 1.5 1 0 0 1 1 1 1 C1 domain FTA4 PF13093.6 VDK87256.1 - 0.019 14.9 1.1 0.029 14.3 1.1 1.3 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Spc7 PF08317.11 VDK87256.1 - 0.037 12.9 10.5 0.07 12.0 10.5 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein HOOK PF05622.12 VDK87256.1 - 0.061 11.5 10.0 0.087 11.0 10.0 1.1 1 0 0 1 1 1 0 HOOK protein DUF4407 PF14362.6 VDK87256.1 - 0.29 10.5 4.3 0.41 10.0 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 VDK87256.1 - 0.66 8.5 5.4 1 7.9 5.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A MerR-DNA-bind PF09278.11 VDK87256.1 - 1.4 9.5 9.7 1.2 9.7 7.5 2.1 2 0 0 2 2 2 0 MerR, DNA binding APG6_N PF17675.1 VDK87256.1 - 2.2 8.8 14.4 0.15 12.6 8.4 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Dynamin_M PF01031.20 VDK87266.1 - 3.2e-94 315.4 1.0 3.2e-94 315.4 1.0 2.2 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 VDK87266.1 - 2.7e-56 190.2 0.0 9.1e-56 188.5 0.0 2.0 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 VDK87266.1 - 9.3e-25 86.6 1.1 3.1e-24 84.9 1.1 2.0 1 0 0 1 1 1 1 Dynamin GTPase effector domain PH PF00169.29 VDK87266.1 - 4e-10 40.1 0.3 8.5e-10 39.1 0.3 1.6 1 0 0 1 1 1 1 PH domain MMR_HSR1 PF01926.23 VDK87266.1 - 0.00029 20.9 0.0 0.001 19.2 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase RasGAP PF00616.19 VDK87266.1 - 0.016 14.9 0.5 0.11 12.2 0.1 2.2 2 1 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase SANTA PF09133.10 VDK87267.1 - 3.6e-37 126.7 0.0 7.2e-20 71.3 0.0 3.0 2 0 0 2 2 2 2 SANTA (SANT Associated) Myb_DNA-binding PF00249.31 VDK87267.1 - 0.0015 18.7 0.7 0.0045 17.1 0.4 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 VDK87267.1 - 0.018 15.3 0.0 0.069 13.4 0.0 2.1 1 0 0 1 1 1 0 Myb-like DNA-binding domain Ank_2 PF12796.7 VDK87269.1 - 7.5e-40 135.4 6.3 5e-17 62.3 0.0 5.7 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK87269.1 - 5e-34 116.2 9.7 4.3e-07 30.3 0.0 7.4 3 2 4 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK87269.1 - 1.2e-32 108.3 9.9 3.4e-05 23.9 0.0 9.2 8 0 0 8 8 8 7 Ankyrin repeat Ank_5 PF13857.6 VDK87269.1 - 3.4e-32 110.1 9.0 1.8e-06 28.1 0.3 6.7 4 1 3 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 VDK87269.1 - 1.2e-28 98.2 11.2 2e-05 24.8 0.1 8.5 8 0 0 8 8 8 7 Ankyrin repeat SAD_SRA PF02182.17 VDK87269.1 - 0.12 12.1 0.0 0.39 10.4 0.0 1.8 3 0 0 3 3 3 0 SAD/SRA domain Pkinase PF00069.25 VDK87270.1 - 1.3e-79 267.3 0.0 1.7e-79 266.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87270.1 - 3.5e-39 134.6 0.0 4.6e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK87270.1 - 2.6e-06 26.9 0.0 4.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK87270.1 - 0.00018 20.9 0.3 0.00048 19.6 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 VDK87270.1 - 0.0012 18.5 0.1 0.002 17.8 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 VDK87270.1 - 0.0028 16.5 0.0 0.008 15.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 VDK87270.1 - 0.0058 16.6 0.0 1.2 9.0 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Mrpl_C PF18502.1 VDK87270.1 - 0.05 13.9 0.2 1.3 9.3 0.0 2.4 3 0 0 3 3 3 0 54S ribosomal protein L8 C-terminal domain Collagen PF01391.18 VDK87271.1 - 9.2e-28 95.8 98.9 3.3e-11 42.8 31.6 4.0 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Peptidase_M16_C PF05193.21 VDK87274.1 - 4.4e-33 114.8 0.0 8.2e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 VDK87274.1 - 2.9e-25 89.0 0.0 4.6e-25 88.3 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) XendoU PF09412.10 VDK87275.1 - 8.5e-79 264.5 1.0 1.1e-78 264.1 1.0 1.2 1 0 0 1 1 1 1 Endoribonuclease XendoU Calponin PF00402.18 VDK87275.1 - 2e-10 40.1 0.8 1e-05 25.1 0.9 2.6 2 0 0 2 2 2 2 Calponin family repeat EndoU_bacteria PF14436.6 VDK87275.1 - 0.022 15.1 0.0 0.11 12.9 0.0 2.2 3 0 0 3 3 3 0 Bacterial EndoU nuclease Cas9_REC PF16592.5 VDK87275.1 - 0.024 13.4 0.1 0.037 12.8 0.1 1.2 1 0 0 1 1 1 0 REC lobe of CRISPR-associated endonuclease Cas9 YqzE PF14038.6 VDK87280.1 - 0.036 14.1 0.6 0.036 14.1 0.6 1.0 1 0 0 1 1 1 0 YqzE-like protein CYSTM PF12734.7 VDK87280.1 - 4 7.8 8.8 3.7 8.0 8.8 1.1 1 0 0 1 1 1 0 Cysteine-rich TM module stress tolerance Erf4 PF10256.9 VDK87283.1 - 2.8e-28 98.4 0.0 3.3e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family C6 PF01681.17 VDK87284.1 - 0.039 14.5 1.2 0.052 14.1 1.2 1.3 1 0 0 1 1 1 0 C6 domain zf-RING_11 PF17123.5 VDK87291.1 - 3e-06 26.9 4.4 6.5e-06 25.8 4.4 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 VDK87291.1 - 4.9e-05 23.1 7.4 8.3e-05 22.4 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK87291.1 - 0.00011 22.4 12.3 0.00017 21.8 12.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 VDK87291.1 - 0.00028 20.9 3.0 0.00056 19.9 3.0 1.6 1 1 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 VDK87291.1 - 0.0013 18.1 0.6 0.0017 17.8 0.6 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger zf-C3HC4_2 PF13923.6 VDK87291.1 - 0.0024 17.7 12.0 0.004 17.0 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK87291.1 - 0.018 15.0 10.7 0.033 14.1 10.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Lebercilin PF15619.6 VDK87291.1 - 0.036 13.7 8.5 0.3 10.7 1.0 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Prok-RING_4 PF14447.6 VDK87291.1 - 0.079 12.8 8.4 0.21 11.4 8.5 1.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 VDK87291.1 - 0.1 12.9 11.5 0.39 11.0 11.5 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 VDK87291.1 - 0.22 11.2 8.8 0.34 10.6 8.8 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 VDK87291.1 - 4.8 7.3 8.2 18 5.5 8.2 1.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger MFS_1 PF07690.16 VDK87292.1 - 1.4e-31 109.8 28.8 6e-30 104.4 14.7 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily TFIID_20kDa PF03847.13 VDK87293.1 - 7.3e-18 64.8 2.7 1.1e-17 64.2 2.7 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.15 VDK87293.1 - 0.00013 22.0 0.0 0.00039 20.5 0.0 1.9 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TFIID-18kDa PF02269.16 VDK87293.1 - 0.0018 18.3 0.3 0.0042 17.1 0.3 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CBFD_NFYB_HMF PF00808.23 VDK87293.1 - 0.0029 17.8 0.4 0.0029 17.8 0.4 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 VDK87293.1 - 0.028 14.5 0.8 0.028 14.5 0.8 2.4 2 2 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold RCDG1 PF15725.5 VDK87293.1 - 0.033 14.6 0.2 0.1 13.1 0.2 1.8 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Histone PF00125.24 VDK87293.1 - 0.54 10.6 0.1 0.54 10.6 0.1 2.9 3 0 0 3 3 3 0 Core histone H2A/H2B/H3/H4 EPL1 PF10513.9 VDK87293.1 - 4.2 7.7 9.2 2.7 8.4 7.4 1.6 2 0 0 2 2 2 0 Enhancer of polycomb-like Peptidase_M14 PF00246.24 VDK87298.1 - 1.1e-84 284.6 0.1 1.3e-84 284.4 0.1 1.0 1 0 0 1 1 1 1 Zinc carboxypeptidase Guanylate_kin PF00625.21 VDK87299.1 - 1e-49 168.7 0.0 1.2e-49 168.5 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase RrnaAD PF00398.20 VDK87300.1 - 1.1e-31 109.9 0.0 1.3e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MutS_II PF05188.17 VDK87301.1 - 0.79 10.0 4.8 1.4 9.2 0.3 2.8 1 1 2 3 3 3 0 MutS domain II EMC3_TMCO1 PF01956.16 VDK87301.1 - 5.3 6.7 11.4 0.45 10.2 2.8 2.4 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DAAD PF18752.1 VDK87301.1 - 5.6 6.7 6.2 10 5.9 6.2 1.6 1 1 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase Phosphodiest PF01663.22 VDK87308.1 - 1.2e-56 192.9 0.8 1.5e-56 192.5 0.8 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 VDK87308.1 - 0.02 14.3 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily MFS_1 PF07690.16 VDK87309.1 - 1.9e-41 142.1 39.6 2.5e-34 118.7 21.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Laminin_G_2 PF02210.24 VDK87313.1 - 6.2e-18 65.6 11.7 3.2e-10 40.7 0.2 5.5 6 0 0 6 6 6 3 Laminin G domain Laminin_G_1 PF00054.23 VDK87313.1 - 1.3e-09 38.3 3.0 0.15 12.3 0.0 5.7 5 1 0 5 5 5 3 Laminin G domain Malic_M PF03949.15 VDK87317.1 - 2.1e-34 119.0 0.0 2.5e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain Malic_M PF03949.15 VDK87318.1 - 4.1e-98 327.8 0.0 5.2e-98 327.4 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 VDK87318.1 - 2.8e-76 255.4 0.0 4.6e-76 254.7 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain tRNA-synt_2c PF01411.19 VDK87319.1 - 6.6e-167 556.4 0.0 8.3e-167 556.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 VDK87319.1 - 1.8e-13 50.3 0.5 4.4e-13 49.1 0.5 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain HLH PF00010.26 VDK87329.1 - 1.4e-16 60.2 0.7 2.2e-16 59.6 0.7 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1514 PF07438.11 VDK87329.1 - 0.19 11.6 0.0 0.32 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) zf-H2C2_2 PF13465.6 VDK87331.1 - 2.7e-12 46.5 59.1 0.0074 16.7 0.0 11.0 11 0 0 11 11 11 7 Zinc-finger double domain zf-Di19 PF05605.12 VDK87331.1 - 4.4e-08 33.3 61.5 0.0031 17.8 0.3 8.2 7 2 2 9 9 9 6 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 VDK87331.1 - 0.00019 22.0 80.5 0.89 10.6 0.8 13.1 12 0 0 12 12 12 8 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK87331.1 - 0.00024 20.8 3.7 0.0018 18.0 0.3 9.0 12 0 0 12 12 12 3 C2H2-type zinc-finger domain PHZA_PHZB PF03284.13 VDK87331.1 - 0.012 15.3 1.8 3.9 7.1 0.0 3.5 3 0 0 3 3 3 0 Phenazine biosynthesis protein A/B GatB_N PF02934.15 VDK87332.1 - 2.7e-31 109.0 0.3 5.1e-31 108.1 0.3 1.4 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 VDK87332.1 - 1.3e-11 44.6 3.3 1.8e-11 44.1 1.6 1.9 1 1 1 2 2 2 1 GatB domain DUF2321 PF10083.9 VDK87332.1 - 0.00054 19.6 4.8 0.056 13.1 2.3 2.3 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2321) Baculo_p48 PF04878.13 VDK87332.1 - 0.00083 18.4 1.3 0.0016 17.5 1.3 1.5 1 0 0 1 1 1 1 Baculovirus P48 protein Herpes_LMP2 PF07415.11 VDK87332.1 - 0.013 14.3 0.0 0.017 14.0 0.0 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein CBP_BcsF PF11120.8 VDK87332.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF FtsJ PF01728.19 VDK87333.1 - 1.3e-67 227.3 0.2 1.8e-67 226.8 0.2 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase GatB_N PF02934.15 VDK87333.1 - 5.6e-40 137.4 0.0 8.7e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain PHR PF08005.12 VDK87337.1 - 1e-30 107.4 0.0 2.2e-30 106.3 0.0 1.6 1 0 0 1 1 1 1 PHR domain zf-RING_2 PF13639.6 VDK87337.1 - 8.2e-07 29.3 7.4 8.2e-07 29.3 7.4 6.4 7 1 0 7 7 7 1 Ring finger domain SH3_3 PF08239.11 VDK87337.1 - 9.7e-07 29.0 0.0 2.4e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain zf-B_box PF00643.24 VDK87337.1 - 0.0016 18.5 10.5 0.0016 18.5 10.5 6.6 5 1 0 5 5 5 1 B-box zinc finger zf-RING_11 PF17123.5 VDK87337.1 - 0.0088 15.8 10.5 0.032 14.0 8.1 3.3 2 0 0 2 2 2 1 RING-like zinc finger DUF3619 PF12279.8 VDK87337.1 - 0.031 14.6 0.0 0.085 13.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) zf-rbx1 PF12678.7 VDK87337.1 - 0.12 12.7 17.1 0.016 15.5 10.6 3.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain SCNM1_acidic PF15805.5 VDK87337.1 - 0.14 11.9 0.8 0.52 10.1 0.3 2.1 2 0 0 2 2 2 0 Acidic C-terminal region of sodium channel modifier 1 SCNM1 7tm_1 PF00001.21 VDK87341.1 - 8.8e-06 25.2 9.2 1.1e-05 24.9 9.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srv PF10323.9 VDK87341.1 - 3.8e-05 23.2 12.5 4.5e-05 23.0 12.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv 7TM_GPCR_Srsx PF10320.9 VDK87341.1 - 0.0002 20.8 14.9 0.00025 20.5 14.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx DUF3169 PF11368.8 VDK87341.1 - 0.00046 19.8 1.7 0.00046 19.8 1.7 2.0 1 1 0 2 2 2 1 Protein of unknown function (DUF3169) Borrelia_P13 PF05628.12 VDK87341.1 - 0.052 13.5 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Borrelia membrane protein P13 ERGIC_N PF13850.6 VDK87341.1 - 0.48 10.8 3.6 0.81 10.1 0.1 2.6 2 1 1 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PDR_CDR PF06422.12 VDK87341.1 - 1.9 8.4 5.9 4.3 7.3 0.2 2.6 2 1 1 3 3 3 0 CDR ABC transporter Sigma_reg_N PF13800.6 VDK87341.1 - 8.3 6.8 9.4 1.5 9.1 0.1 3.0 2 1 1 3 3 3 0 Sigma factor regulator N-terminal adh_short PF00106.25 VDK87344.1 - 5.6e-35 120.6 0.2 5e-25 88.1 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 VDK87344.1 - 1.1e-32 113.5 0.0 4.5e-23 82.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK87344.1 - 9.3e-09 35.4 0.0 1.3e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 VDK87344.1 - 2.7e-07 30.3 0.2 1e-06 28.4 0.1 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 VDK87344.1 - 6.5e-05 22.2 0.0 9.5e-05 21.7 0.0 1.3 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 VDK87344.1 - 0.0015 18.0 0.1 0.0072 15.8 0.0 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase ADH_zinc_N PF00107.26 VDK87344.1 - 0.067 13.2 0.0 0.15 12.0 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Rogdi_lz PF10259.9 VDK87345.1 - 3.1e-16 59.6 0.4 3.7e-16 59.4 0.4 1.1 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein AAA PF00004.29 VDK87346.1 - 1e-35 123.0 0.0 2.1e-35 122.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 VDK87346.1 - 1.6e-07 31.2 0.0 3.5e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 VDK87346.1 - 4.1e-07 29.5 0.0 9.1e-07 28.4 0.0 1.5 2 0 0 2 2 1 1 TIP49 P-loop domain AAA_16 PF13191.6 VDK87346.1 - 2.6e-06 27.9 0.1 1.2e-05 25.7 0.0 2.1 2 1 0 2 2 1 1 AAA ATPase domain AAA_5 PF07728.14 VDK87346.1 - 3e-06 27.3 0.0 1.3e-05 25.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 VDK87346.1 - 6.1e-06 26.5 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 VDK87346.1 - 1.2e-05 25.6 0.2 0.0027 18.0 0.2 3.0 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 VDK87346.1 - 2.3e-05 24.4 0.1 0.24 11.3 0.1 2.4 1 1 1 2 2 2 2 NACHT domain RNA_helicase PF00910.22 VDK87346.1 - 0.00021 21.6 0.0 0.00053 20.3 0.0 1.8 1 1 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 VDK87346.1 - 0.00038 21.0 0.0 0.00085 19.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 VDK87346.1 - 0.0004 20.3 0.0 0.0013 18.7 0.0 1.7 1 1 0 1 1 1 1 Bacterial dnaA protein AAA_14 PF13173.6 VDK87346.1 - 0.0006 19.9 0.0 0.0014 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 VDK87346.1 - 0.00094 19.2 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 VDK87346.1 - 0.0011 18.7 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 VDK87346.1 - 0.0015 17.8 0.0 0.17 11.1 0.0 2.3 1 1 1 2 2 2 1 KAP family P-loop domain AAA_7 PF12775.7 VDK87346.1 - 0.0023 17.5 0.0 0.086 12.3 0.0 2.4 1 1 1 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 VDK87346.1 - 0.0026 17.9 0.0 0.0044 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 VDK87346.1 - 0.004 16.9 0.0 0.0064 16.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_19 PF13245.6 VDK87346.1 - 0.0051 17.2 0.0 0.011 16.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 VDK87346.1 - 0.0055 17.1 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.17 VDK87346.1 - 0.0067 15.5 0.0 0.019 14.0 0.0 1.7 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Mg_chelatase PF01078.21 VDK87346.1 - 0.011 15.1 0.0 0.04 13.3 0.0 1.8 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 VDK87346.1 - 0.012 15.2 0.1 0.19 11.3 0.0 2.3 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 VDK87346.1 - 0.012 15.0 0.1 1.3 8.3 0.0 2.8 2 1 1 3 3 3 0 KaiC Viral_helicase1 PF01443.18 VDK87346.1 - 0.016 15.0 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 VDK87346.1 - 0.022 14.5 0.0 1.5 8.5 0.0 2.5 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_3 PF07726.11 VDK87346.1 - 0.033 14.0 0.0 0.056 13.3 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 VDK87346.1 - 0.041 13.8 0.0 0.15 11.9 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 VDK87346.1 - 0.062 13.6 0.0 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 VDK87346.1 - 0.094 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_6 PF12774.7 VDK87346.1 - 0.17 10.8 0.0 6.2 5.7 0.0 2.1 1 1 1 2 2 2 0 Hydrolytic ATP binding site of dynein motor region Neur_chan_LBD PF02931.23 VDK87347.1 - 3.4e-43 147.6 2.7 4.5e-43 147.2 2.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK87347.1 - 5.5e-24 85.5 5.2 1.3e-19 71.2 2.7 2.8 3 0 0 3 3 3 2 Neurotransmitter-gated ion-channel transmembrane region zf-HC5HC2H PF13771.6 VDK87349.1 - 0.087 13.1 0.8 0.21 11.9 0.2 2.0 2 0 0 2 2 2 0 PHD-like zinc-binding domain SprB PF13573.6 VDK87349.1 - 0.43 10.4 2.6 3.6 7.4 0.1 3.3 4 0 0 4 4 4 0 SprB repeat PSP94 PF05825.11 VDK87349.1 - 1.2 9.8 5.1 0.51 10.9 0.3 2.4 2 1 1 3 3 3 0 Beta-microseminoprotein (PSP-94) zf-HIT PF04438.16 VDK87352.1 - 6.2e-08 32.4 8.9 6.2e-08 32.4 8.9 1.6 2 0 0 2 2 2 1 HIT zinc finger DUF287 PF03384.14 VDK87352.1 - 0.097 13.1 0.2 3.5 8.1 0.0 2.7 2 0 0 2 2 2 0 Drosophila protein of unknown function, DUF287 S-AdoMet_synt_N PF00438.20 VDK87353.1 - 5.9e-21 75.0 0.2 7e-21 74.8 0.2 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 VDK87353.1 - 0.054 12.3 0.0 0.054 12.3 0.0 1.0 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) S-AdoMet_synt_C PF02773.16 VDK87354.1 - 7.8e-66 220.3 0.1 3.2e-65 218.3 0.0 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 VDK87354.1 - 2.2e-43 147.3 0.0 3.4e-43 146.7 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 VDK87354.1 - 1e-11 45.4 0.2 2.6e-11 44.1 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain Ribosom_S12_S23 PF00164.25 VDK87355.1 - 5.2e-24 84.1 0.3 6e-24 83.9 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Yippee-Mis18 PF03226.14 VDK87356.1 - 1.8e-08 34.5 0.1 3e-08 33.8 0.1 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LON_substr_bdg PF02190.16 VDK87356.1 - 4.5e-07 30.0 0.0 7.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-ribbon_3 PF13248.6 VDK87356.1 - 0.0019 17.5 1.8 0.18 11.3 0.1 2.4 2 0 0 2 2 2 2 zinc-ribbon domain zf-C2HC5 PF06221.13 VDK87356.1 - 0.074 13.1 2.3 0.44 10.6 0.6 2.3 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type DNA_RNApol_7kD PF03604.13 VDK87356.1 - 0.17 11.6 1.3 1.1 9.0 0.2 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit NUDIX_2 PF13869.6 VDK87357.1 - 2.4e-80 268.6 0.0 2.7e-80 268.4 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 VDK87357.1 - 0.026 14.6 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 NUDIX domain RNA_pol_Rpb2_6 PF00562.28 VDK87358.1 - 3.8e-108 362.0 0.0 9.9e-108 360.7 0.0 1.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 VDK87358.1 - 5.1e-30 104.5 0.0 7.7e-30 103.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 VDK87358.1 - 2.9e-27 94.6 0.0 6.4e-27 93.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 VDK87358.1 - 1.7e-23 82.8 0.7 8.2e-23 80.6 0.7 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpa2_4 PF06883.12 VDK87358.1 - 4.2e-15 55.5 0.0 2.6e-14 52.9 0.0 2.3 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 VDK87358.1 - 4.9e-09 36.1 0.0 9.7e-09 35.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 Sulfotransfer_2 PF03567.14 VDK87359.1 - 1.5e-25 90.5 1.9 2.7e-25 89.7 1.9 1.3 1 0 0 1 1 1 1 Sulfotransferase family Homeodomain PF00046.29 VDK87361.1 - 3.8e-20 71.5 2.6 1e-19 70.1 2.6 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK87361.1 - 0.0048 16.8 1.7 0.027 14.4 0.0 2.4 2 0 0 2 2 2 1 Homeobox KN domain SAP18 PF06487.12 VDK87362.1 - 0.14 12.3 0.0 0.17 12.1 0.0 1.0 1 0 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) fn3 PF00041.21 VDK87367.1 - 5.3e-92 302.3 29.3 2e-12 47.2 0.3 10.5 10 0 0 10 10 10 9 Fibronectin type III domain Ig_3 PF13927.6 VDK87367.1 - 1.8e-34 118.1 8.6 4.5e-05 24.0 0.0 9.0 9 0 0 9 9 9 6 Immunoglobulin domain I-set PF07679.16 VDK87367.1 - 5.5e-26 90.5 1.8 0.0015 18.6 0.0 10.6 9 2 0 9 9 9 3 Immunoglobulin I-set domain Pur_ac_phosph_N PF16656.5 VDK87367.1 - 1.1e-24 86.9 4.4 0.01 16.4 0.0 9.9 10 0 0 10 10 10 5 Purple acid Phosphatase, N-terminal domain Ig_2 PF13895.6 VDK87367.1 - 9.3e-16 57.9 0.4 0.11 12.9 0.0 7.9 7 0 0 7 7 7 4 Immunoglobulin domain ig PF00047.25 VDK87367.1 - 1.8e-14 53.6 0.1 9.4e-05 22.5 0.0 7.4 7 0 0 7 7 7 1 Immunoglobulin domain C2-set_2 PF08205.12 VDK87367.1 - 1.7e-09 37.6 6.8 0.32 11.1 0.0 7.4 7 1 0 7 7 7 2 CD80-like C2-set immunoglobulin domain FXa_inhibition PF14670.6 VDK87367.1 - 1.7e-08 34.6 7.5 1.7e-08 34.6 7.5 2.8 2 0 0 2 2 2 1 Coagulation Factor Xa inhibitory site Interfer-bind PF09294.10 VDK87367.1 - 0.0079 16.5 0.0 3 8.2 0.0 4.9 6 0 0 6 6 5 1 Interferon-alpha/beta receptor, fibronectin type III Glyco_hydro_36C PF16874.5 VDK87367.1 - 0.023 15.2 0.1 3.4 8.2 0.0 4.2 5 0 0 5 5 5 0 Glycosyl hydrolase family 36 C-terminal domain PTP_tm PF18861.1 VDK87367.1 - 0.097 12.7 0.0 4.1 7.4 0.0 2.7 2 0 0 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J PhoD_N PF16655.5 VDK87367.1 - 0.11 13.1 0.1 1.5e+02 3.0 0.0 5.3 6 0 0 6 6 6 0 PhoD-like phosphatase, N-terminal domain DUF2369 PF10179.9 VDK87367.1 - 0.11 12.9 0.0 40 4.7 0.0 3.7 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) 6PGD PF00393.19 VDK87373.1 - 7.3e-122 406.3 0.0 9.7e-122 405.9 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 VDK87373.1 - 2.7e-50 170.6 0.0 3.9e-50 170.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 VDK87373.1 - 5.3e-05 23.3 0.2 0.00019 21.5 0.1 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 VDK87373.1 - 0.0051 17.4 0.1 0.0099 16.4 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.6 VDK87373.1 - 0.049 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 VDK87373.1 - 0.062 12.7 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 VDK87373.1 - 0.079 12.5 0.5 0.67 9.5 0.0 2.3 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain EF-hand_6 PF13405.6 VDK87375.1 - 0.016 15.1 0.1 0.077 13.0 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 VDK87375.1 - 0.028 13.9 0.6 0.065 12.8 0.1 1.8 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 VDK87375.1 - 0.12 12.2 0.1 0.31 10.9 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair Metallophos PF00149.28 VDK87379.1 - 9.7e-07 29.5 0.0 1.6e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MADF_DNA_bdg PF10545.9 VDK87381.1 - 2.1e-07 31.1 0.1 4.1e-07 30.2 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK87381.1 - 0.027 14.8 0.5 0.047 14.1 0.5 1.3 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Viral_DNA_Zn_bi PF03728.13 VDK87381.1 - 0.052 14.1 0.2 0.061 13.9 0.2 1.2 1 0 0 1 1 1 0 Viral DNA-binding protein, zinc binding domain WH2 PF02205.20 VDK87382.1 - 1e-30 104.7 14.7 1.1e-09 37.7 0.3 5.9 6 0 0 6 6 6 4 WH2 motif DUF591 PF04569.14 VDK87382.1 - 0.19 11.8 1.5 20 5.3 0.5 2.9 2 0 0 2 2 2 0 Protein of unknown function Neuraminidase PF18413.1 VDK87386.1 - 0.038 13.6 0.0 0.065 12.9 0.0 1.5 1 0 0 1 1 1 0 Neuraminidase-like domain 7tm_3 PF00003.22 VDK87391.1 - 4.5e-28 98.6 18.8 6.1e-28 98.2 18.8 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Ribosomal_S26e PF01283.19 VDK87392.1 - 4e-54 181.6 6.2 4.6e-54 181.4 6.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e Fer4_7 PF12838.7 VDK87392.1 - 0.014 16.0 1.1 0.15 12.7 0.6 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4 PF00037.27 VDK87392.1 - 0.11 12.3 0.3 0.11 12.3 0.3 1.9 2 0 0 2 2 2 0 4Fe-4S binding domain zf-LITAF-like PF10601.9 VDK87394.1 - 1e-22 80.2 9.5 1.7e-22 79.5 9.5 1.4 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain zf-RING_7 PF02591.15 VDK87394.1 - 0.033 14.4 5.4 0.074 13.3 0.8 2.5 2 0 0 2 2 2 0 C4-type zinc ribbon domain DUF2614 PF11023.8 VDK87394.1 - 0.67 10.1 3.6 0.83 9.8 2.6 1.7 1 1 1 2 2 2 0 Zinc-ribbon containing domain RNA_pol_N PF01194.17 VDK87395.1 - 5.1e-32 110.0 0.3 5.7e-32 109.8 0.3 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 VDK87395.1 - 0.047 13.9 0.6 0.082 13.2 0.6 1.5 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Prefoldin_2 PF01920.20 VDK87396.1 - 4.2e-13 49.2 6.5 7.7e-10 38.7 1.1 2.1 2 0 0 2 2 2 2 Prefoldin subunit DUF2951 PF11166.8 VDK87396.1 - 0.042 14.1 3.1 0.7 10.1 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) MbeB_N PF04837.12 VDK87396.1 - 1.7 9.0 5.7 5.6 7.4 0.2 3.3 4 0 0 4 4 4 0 MbeB-like, N-term conserved region DUF2175 PF09943.9 VDK87396.1 - 2.4 8.5 5.7 5.3 7.4 0.8 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) TPR_18 PF13512.6 VDK87398.1 - 0.14 12.3 0.1 0.23 11.6 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Mucin PF01456.17 VDK87400.1 - 0.028 14.4 34.6 0.035 14.1 34.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 VDK87400.1 - 0.12 12.8 13.9 0.16 12.4 13.9 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin RIFIN PF02009.16 VDK87400.1 - 4.5 7.1 9.2 5.3 6.8 9.2 1.1 1 0 0 1 1 1 0 Rifin PhoLip_ATPase_C PF16212.5 VDK87400.1 - 5.7 6.6 10.3 6.2 6.5 10.3 1.0 1 0 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal SAM_2 PF07647.17 VDK87401.1 - 8.8e-31 105.8 1.9 1.4e-12 47.6 0.0 3.7 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 VDK87401.1 - 2.8e-28 98.1 2.0 4.2e-14 52.7 0.4 3.5 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 VDK87401.1 - 0.037 14.0 1.3 0.38 10.7 0.0 2.9 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain Troponin PF00992.20 VDK87401.1 - 0.27 11.5 6.9 0.55 10.5 5.9 1.9 1 1 0 1 1 1 0 Troponin UPF0242 PF06785.11 VDK87401.1 - 4.5 7.3 15.0 16 5.5 13.7 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus KASH_CCD PF14662.6 VDK87401.1 - 8.8 6.1 19.6 30 4.4 2.7 3.5 3 1 1 4 4 4 0 Coiled-coil region of CCDC155 or KASH OTU PF02338.19 VDK87404.1 - 2.7e-13 50.5 0.0 1.2e-11 45.1 0.0 2.2 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 VDK87404.1 - 0.0013 18.3 0.0 0.5 9.8 0.0 2.3 2 0 0 2 2 2 2 Peptidase C65 Otubain LmjF365940-deam PF14421.6 VDK87405.1 - 0.11 12.1 0.4 0.12 12.0 0.4 1.0 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases DUF3295 PF11702.8 VDK87406.1 - 2.1 7.6 14.3 2.5 7.4 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) 7tm_1 PF00001.21 VDK87407.1 - 1.4e-56 191.8 22.1 1.4e-56 191.8 22.1 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srx PF10328.9 VDK87407.1 - 2.7e-08 33.8 13.6 2.7e-08 33.8 13.6 2.6 2 1 1 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srsx PF10320.9 VDK87407.1 - 5.3e-05 22.7 33.0 0.00088 18.7 33.0 2.1 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 VDK87407.1 - 9.4e-05 22.3 16.3 0.00028 20.7 16.3 1.8 1 1 0 1 1 1 1 Olfactory receptor Lipoprotein_22 PF17294.2 VDK87407.1 - 0.0014 18.3 1.1 0.014 15.1 0.1 2.2 2 0 0 2 2 2 1 Uncharacterised lipoprotein family Diphthamide_syn PF01866.17 VDK87408.1 - 1.1e-108 363.3 0.4 1.5e-107 359.6 0.4 2.0 1 1 0 1 1 1 1 Putative diphthamide synthesis protein Histone_H2A_C PF16211.5 VDK87409.1 - 3e-20 71.6 1.0 6.3e-20 70.6 1.0 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 VDK87409.1 - 3.6e-16 59.7 0.0 4.5e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 VDK87409.1 - 4.1e-07 30.2 0.0 5.8e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Sigma_reg_N PF13800.6 VDK87411.1 - 7.5 6.9 7.7 1.6 9.1 1.1 2.5 2 1 0 2 2 2 0 Sigma factor regulator N-terminal Pkinase_Tyr PF07714.17 VDK87412.1 - 3.9e-35 121.4 0.0 5.9e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 VDK87412.1 - 9.5e-29 99.8 4.1 2e-15 57.1 0.2 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 VDK87412.1 - 1.1e-21 77.4 0.0 5.3e-21 75.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 VDK87412.1 - 7.4e-19 67.9 1.3 3e-09 37.2 0.2 3.6 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDK87412.1 - 3.5e-18 65.4 9.5 8.8e-10 38.7 1.6 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 VDK87412.1 - 4.5e-17 61.7 1.0 1.1e-05 25.6 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 VDK87412.1 - 4.4e-14 51.2 1.4 0.003 17.9 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat MADF_DNA_bdg PF10545.9 VDK87413.1 - 0.00025 21.3 0.1 0.00065 20.0 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase transcription factor Myb/SANT-like BEN PF10523.9 VDK87413.1 - 0.49 10.7 5.7 3.9 7.8 0.1 3.1 4 0 0 4 4 4 0 BEN domain COX6C PF02937.15 VDK87414.1 - 1.6e-05 24.9 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc CRAL_TRIO PF00650.20 VDK87416.1 - 2.6e-24 85.7 0.0 3.4e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Kunitz_BPTI PF00014.23 VDK87419.1 - 1.6e-176 572.6 176.7 4.3e-18 65.3 6.4 13.6 13 0 0 13 13 13 11 Kunitz/Bovine pancreatic trypsin inhibitor domain ADAM_spacer1 PF05986.14 VDK87419.1 - 1e-29 102.9 0.0 1.7e-29 102.1 0.0 1.4 1 0 0 1 1 1 1 ADAM-TS Spacer 1 TSP_1 PF00090.19 VDK87419.1 - 2.1e-23 82.3 90.0 7.1e-07 29.3 11.1 9.6 8 0 0 8 8 8 6 Thrombospondin type 1 domain Ig_3 PF13927.6 VDK87419.1 - 1.7e-08 35.0 0.0 1e-07 32.4 0.0 2.4 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 VDK87419.1 - 1.1e-05 25.3 0.0 2.8e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 VDK87419.1 - 0.004 17.3 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 Immunoglobulin domain MAAL_N PF05034.13 VDK87419.1 - 1.2 8.8 5.3 43 3.7 0.0 4.4 5 0 0 5 5 5 0 Methylaspartate ammonia-lyase N-terminus BTB PF00651.31 VDK87426.1 - 6.1e-26 90.8 0.9 1.5e-25 89.5 0.4 2.0 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 VDK87426.1 - 8.8e-07 29.0 0.6 1.8e-06 28.0 0.1 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch zf-Di19 PF05605.12 VDK87426.1 - 0.00064 20.0 4.6 0.0015 18.8 4.6 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_5 PF13909.6 VDK87426.1 - 0.0041 16.8 3.3 0.0041 16.8 3.3 3.5 3 0 0 3 3 3 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 VDK87426.1 - 0.0083 16.9 11.4 0.14 13.1 2.0 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger DUF3342 PF11822.8 VDK87426.1 - 0.0084 16.3 0.3 0.024 14.8 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C2H2_7 PF15269.6 VDK87426.1 - 0.18 11.9 1.3 0.53 10.4 1.3 1.8 1 0 0 1 1 1 0 Zinc-finger zf-C2H2 PF00096.26 VDK87426.1 - 0.73 10.4 12.7 0.37 11.3 2.2 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type AT_hook PF02178.19 VDK87426.1 - 0.97 9.5 5.5 2.2 8.4 5.5 1.6 1 0 0 1 1 1 0 AT hook motif adh_short PF00106.25 VDK87427.1 - 4.3e-33 114.4 0.0 5.1e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK87427.1 - 1.8e-27 96.4 0.0 2.4e-27 96.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK87427.1 - 1.4e-07 31.6 0.1 4.2e-07 30.0 0.1 1.9 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 VDK87427.1 - 0.0061 15.6 0.1 0.044 12.8 0.1 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 VDK87427.1 - 0.027 13.9 0.1 0.071 12.6 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family CaKB PF03185.15 VDK87427.1 - 0.073 12.7 0.0 0.14 11.8 0.0 1.4 1 1 0 1 1 1 0 Calcium-activated potassium channel, beta subunit GDP_Man_Dehyd PF16363.5 VDK87427.1 - 0.13 11.7 0.1 0.34 10.3 0.1 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 VDK87428.1 - 1e-46 158.9 0.2 1.2e-46 158.7 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK87428.1 - 6.2e-45 153.6 0.0 7.4e-45 153.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK87428.1 - 4.1e-11 43.1 2.8 1.1e-10 41.8 2.8 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 VDK87428.1 - 1e-06 28.4 0.4 1.3e-05 24.8 0.4 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 VDK87428.1 - 0.003 17.5 0.0 0.0056 16.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Polysacc_synt_2 PF02719.15 VDK87428.1 - 0.0047 16.1 0.0 0.0078 15.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 VDK87428.1 - 0.043 13.2 0.1 0.13 11.7 0.0 1.9 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase WAPL PF07814.13 VDK87429.1 - 1.1e-76 258.0 15.0 1.6e-76 257.5 15.0 1.2 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin HSNSD PF12062.8 VDK87430.1 - 1.4e-189 631.0 2.0 2.1e-189 630.3 2.0 1.2 1 0 0 1 1 1 1 heparan sulfate-N-deacetylase Sulfotransfer_1 PF00685.27 VDK87430.1 - 3.6e-26 92.2 0.0 6.7e-26 91.3 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 VDK87430.1 - 5.7e-09 36.7 0.4 0.00054 20.4 0.1 2.5 1 1 1 2 2 2 2 Sulfotransferase family EF-hand_7 PF13499.6 VDK87434.1 - 1.1e-20 73.8 8.7 2.6e-12 47.0 0.4 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 VDK87434.1 - 9.8e-18 62.5 3.2 0.00036 20.2 0.0 5.4 4 1 2 6 6 6 3 EF-hand domain EF-hand_1 PF00036.32 VDK87434.1 - 6.3e-17 59.8 10.5 5.6e-05 22.4 0.3 4.7 6 0 0 6 6 6 3 EF hand EF-hand_5 PF13202.6 VDK87434.1 - 2.8e-10 39.2 6.1 0.0055 16.1 0.0 4.2 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 VDK87434.1 - 1.7e-07 31.0 11.1 0.0017 18.1 0.6 4.0 2 1 2 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 VDK87434.1 - 0.00032 21.0 1.4 0.79 10.1 0.0 3.4 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 VDK87434.1 - 0.0016 18.8 2.8 3 8.2 0.0 3.2 3 1 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_13 PF17958.1 VDK87434.1 - 0.0099 15.7 0.2 1.1 9.1 0.0 3.0 3 1 0 3 3 3 1 EF-hand domain EF-hand_4 PF12763.7 VDK87434.1 - 0.013 15.4 6.5 9.4 6.2 0.4 3.7 1 1 3 4 4 4 0 Cytoskeletal-regulatory complex EF hand Homez PF11569.8 VDK87434.1 - 0.099 12.1 0.1 0.23 10.9 0.1 1.6 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez DUF3194 PF11419.8 VDK87434.1 - 0.2 12.0 1.3 1.4 9.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3194) Cyclin_C_2 PF16899.5 VDK87435.1 - 4.1e-19 68.9 0.1 1.1e-16 61.1 0.0 2.4 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 VDK87435.1 - 3.9e-08 33.1 0.2 1.1e-07 31.6 0.1 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 VDK87435.1 - 0.0006 19.9 0.1 0.0045 17.1 0.0 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain FAA_hydro_N_2 PF18288.1 VDK87435.1 - 0.045 14.2 0.0 0.15 12.5 0.0 1.9 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 TFIIB PF00382.19 VDK87435.1 - 0.12 12.5 0.0 0.6 10.2 0.0 2.1 3 0 0 3 3 3 0 Transcription factor TFIIB repeat Raf1_HTH PF18579.1 VDK87460.1 - 0.024 14.3 0.4 0.046 13.4 0.4 1.4 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain HORMA PF02301.18 VDK87462.1 - 0.094 12.3 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 HORMA domain PNRC PF15365.6 VDK87463.1 - 2.6e-05 23.9 0.9 2.6e-05 23.9 0.9 2.8 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif YidD PF01809.18 VDK87464.1 - 0.045 13.6 0.8 0.088 12.7 0.8 1.5 1 0 0 1 1 1 0 Putative membrane protein insertion efficiency factor zf-BED PF02892.15 VDK87472.1 - 4.3e-10 39.5 9.5 5.1e-05 23.2 0.4 2.7 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_4 PF13894.6 VDK87472.1 - 0.1 13.5 14.3 1.9 9.5 5.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger OrsD PF12013.8 VDK87472.1 - 0.61 10.5 7.9 0.31 11.5 0.4 3.5 4 0 0 4 4 4 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 VDK87472.1 - 4.2 7.2 26.8 0.61 9.9 8.7 3.3 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Pkinase PF00069.25 VDK87473.1 - 9.2e-53 179.3 0.0 1.3e-52 178.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87473.1 - 1.8e-21 76.6 0.0 2.8e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK87473.1 - 1e-05 25.0 0.1 1.9e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK87473.1 - 0.016 15.1 0.0 0.024 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family ETAA1 PF15350.6 VDK87473.1 - 0.024 13.0 0.4 0.03 12.6 0.4 1.1 1 0 0 1 1 1 0 Ewing's tumour-associated antigen 1 homologue SET PF00856.28 VDK87475.1 - 3.9e-19 69.6 0.0 3.9e-19 69.6 0.0 2.9 3 2 1 4 4 4 1 SET domain AWS PF17907.1 VDK87475.1 - 3.9e-08 33.2 4.4 3.9e-08 33.2 4.4 2.1 2 0 0 2 2 2 1 AWS domain Glyco_hydro_2 PF00703.21 VDK87475.1 - 6.5 7.5 6.8 1.2 9.9 0.5 3.0 3 0 0 3 3 3 0 Glycosyl hydrolases family 2 TFIIIC_sub6 PF10419.9 VDK87477.1 - 2e-09 37.2 0.0 5.4e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain COG5 PF10392.9 VDK87477.1 - 4.7e-08 33.3 0.8 4.7e-08 33.3 0.8 3.9 4 0 0 4 4 4 1 Golgi transport complex subunit 5 TAL_effector PF03377.13 VDK87477.1 - 0.059 13.7 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 TAL effector repeat ApoLp-III PF07464.11 VDK87477.1 - 0.087 12.9 3.2 0.47 10.5 0.2 2.8 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) RRF PF01765.19 VDK87477.1 - 0.3 11.0 0.0 0.3 11.0 0.0 2.8 4 0 0 4 4 4 0 Ribosome recycling factor Mod_r PF07200.13 VDK87477.1 - 4.3 7.4 10.6 1.5 9.0 2.1 3.0 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein GTP_EFTU PF00009.27 VDK87478.1 - 1.5e-39 135.5 0.6 2.5e-39 134.9 0.6 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 VDK87478.1 - 1.3e-12 48.0 3.1 3.3e-12 46.6 3.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 VDK87478.1 - 5.5e-07 29.9 0.0 2.2e-06 28.0 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain cobW PF02492.19 VDK87478.1 - 0.0053 16.4 0.3 0.0053 16.4 0.3 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 VDK87478.1 - 0.038 13.9 0.2 0.038 13.9 0.2 1.7 2 0 0 2 2 2 0 RsgA GTPase Pkinase PF00069.25 VDK87479.1 - 1e-26 93.9 0.0 1.3e-26 93.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87479.1 - 4.9e-14 52.2 0.0 6.9e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK87479.1 - 2.3e-06 26.6 0.8 3.4e-06 26.1 0.8 1.2 1 0 0 1 1 1 1 Fungal protein kinase PIP49_C PF12260.8 VDK87479.1 - 0.00064 19.4 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 YrbL-PhoP_reg PF10707.9 VDK87479.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF2958 PF11171.8 VDK87479.1 - 0.2 11.9 0.0 0.37 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2958) CK1gamma_C PF12605.8 VDK87479.1 - 1.5 10.1 4.9 6.4 8.0 4.9 1.9 1 1 0 1 1 1 0 Casein kinase 1 gamma C terminal Zip PF02535.22 VDK87481.1 - 4.6e-50 170.7 7.0 6.8e-50 170.2 7.0 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DctQ PF04290.12 VDK87481.1 - 0.0014 18.5 4.1 0.02 14.8 0.1 2.8 2 1 0 2 2 2 2 Tripartite ATP-independent periplasmic transporters, DctQ component DUF1129 PF06570.11 VDK87481.1 - 0.025 14.1 8.0 0.46 9.9 1.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) RabGAP-TBC PF00566.18 VDK87482.1 - 6.2e-48 163.3 0.2 6.2e-48 163.3 0.2 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.29 VDK87482.1 - 7.9e-07 29.5 0.0 2.3e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 PH domain Atg14 PF10186.9 VDK87482.1 - 0.0087 15.2 4.3 0.024 13.7 4.3 1.8 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1657 PF07870.11 VDK87482.1 - 0.022 14.7 0.1 3.1 7.7 0.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1657) ZapB PF06005.12 VDK87482.1 - 0.044 14.2 0.3 0.044 14.2 0.3 3.9 3 0 0 3 3 3 0 Cell division protein ZapB PH_8 PF15409.6 VDK87482.1 - 0.098 13.0 0.0 0.3 11.4 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain ATG16 PF08614.11 VDK87482.1 - 0.11 12.7 14.4 0.81 9.9 5.7 3.1 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) PH_11 PF15413.6 VDK87482.1 - 1.5 9.3 3.6 23 5.5 0.5 3.6 3 1 0 3 3 3 0 Pleckstrin homology domain Tup_N PF08581.10 VDK87482.1 - 3.3 8.1 13.6 0.16 12.3 1.4 3.6 3 0 0 3 3 3 0 Tup N-terminal CHORD PF04968.12 VDK87485.1 - 7.7e-25 87.4 6.9 7.7e-25 87.4 6.9 2.2 2 0 0 2 2 2 1 CHORD Abhydrolase_8 PF06259.12 VDK87485.1 - 0.14 11.8 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase BTK PF00779.19 VDK87485.1 - 9.5 6.1 15.1 1.8 8.5 5.6 3.2 3 1 0 3 3 3 0 BTK motif F-box PF00646.33 VDK87489.1 - 0.0014 18.5 0.1 0.0085 16.0 0.1 2.5 1 0 0 1 1 1 1 F-box domain FTH PF01827.27 VDK87489.1 - 0.18 11.6 2.1 6 6.7 0.2 2.8 2 1 1 3 3 3 0 FTH domain Fer4 PF00037.27 VDK87490.1 - 2e-14 52.7 17.3 6.7e-09 35.2 4.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 VDK87490.1 - 1.6e-13 51.0 10.1 2.7e-13 50.3 10.1 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 VDK87490.1 - 7.7e-11 42.8 5.5 2.6e-05 25.0 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 VDK87490.1 - 2.9e-09 36.9 33.5 4e-06 26.9 13.0 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 VDK87490.1 - 5.3e-09 36.1 21.9 1.9e-06 27.9 12.8 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 VDK87490.1 - 1.3e-08 34.9 10.2 2.6e-08 33.9 10.2 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 VDK87490.1 - 2.6e-07 31.0 19.6 4.3e-05 23.9 11.1 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 VDK87490.1 - 2.9e-07 30.3 17.7 0.00045 20.2 5.4 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 VDK87490.1 - 1.3e-06 28.1 12.1 0.0026 17.8 1.9 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 VDK87490.1 - 1.2e-05 25.4 11.5 0.00057 20.2 2.5 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 VDK87490.1 - 0.00011 22.7 11.5 0.0034 17.9 12.3 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 VDK87490.1 - 0.0072 16.8 14.8 0.27 11.8 2.8 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 VDK87490.1 - 0.0089 16.9 16.5 0.017 16.0 4.2 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain c-SKI_SMAD_bind PF08782.10 VDK87490.1 - 0.014 15.6 5.1 0.51 10.6 0.3 2.4 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_18 PF13746.6 VDK87490.1 - 0.11 12.6 9.6 4.5 7.5 1.6 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain ETF_QO PF05187.13 VDK87490.1 - 0.37 10.9 5.8 1.7 8.9 0.6 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 VDK87490.1 - 3.4 8.6 13.9 2.6 8.9 1.7 2.6 2 1 1 3 3 2 0 4Fe-4S dicluster domain SpoIIE PF07228.12 VDK87491.1 - 1.4e-13 51.2 0.0 2.4e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 VDK87491.1 - 2.8e-09 37.0 0.0 0.00015 21.5 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 VDK87491.1 - 0.00021 21.0 0.0 0.0025 17.5 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C WD40 PF00400.32 VDK87492.1 - 1.2e-31 108.2 20.9 9.5e-07 29.4 0.8 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK87492.1 - 6.8e-06 26.3 0.2 0.25 11.7 0.0 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK87492.1 - 0.022 14.1 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 WD40-like domain HOOK PF05622.12 VDK87492.1 - 0.14 10.3 1.1 0.19 9.8 1.1 1.1 1 0 0 1 1 1 0 HOOK protein DUF5544 PF17698.1 VDK87493.1 - 0.0087 16.2 1.8 0.0095 16.0 1.8 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5544) Ly-6_related PF06579.12 VDK87497.1 - 5.5e-18 65.4 0.1 8.6e-18 64.8 0.1 1.3 1 0 0 1 1 1 1 Caenorhabditis elegans ly-6-related protein Myosin_tail_1 PF01576.19 VDK87498.1 - 1.9e-77 261.2 182.1 2.3e-77 260.9 182.1 1.0 1 0 0 1 1 1 1 Myosin tail Filament PF00038.21 VDK87498.1 - 1.5e-08 34.6 161.8 0.00022 20.9 15.7 8.2 1 1 6 7 7 7 5 Intermediate filament protein DUF1664 PF07889.12 VDK87498.1 - 0.0011 19.0 99.5 0.018 15.1 8.3 9.7 3 3 5 9 9 9 7 Protein of unknown function (DUF1664) DUF745 PF05335.13 VDK87498.1 - 0.002 17.9 9.7 0.002 17.9 9.7 7.9 1 1 4 7 7 7 4 Protein of unknown function (DUF745) FAM184 PF15665.5 VDK87498.1 - 0.0055 16.5 21.1 0.0055 16.5 21.1 8.0 1 1 5 6 6 6 1 Family with sequence similarity 184, A and B TMF_DNA_bd PF12329.8 VDK87498.1 - 0.012 15.5 5.8 0.012 15.5 5.8 15.7 3 2 11 16 16 16 0 TATA element modulatory factor 1 DNA binding WXG100 PF06013.12 VDK87498.1 - 0.013 15.7 5.2 0.013 15.7 5.2 11.5 6 3 7 14 14 14 0 Proteins of 100 residues with WXG GIT_CC PF16559.5 VDK87498.1 - 0.015 15.1 0.4 0.015 15.1 0.4 12.5 6 2 8 14 14 14 0 GIT coiled-coil Rho guanine nucleotide exchange factor HisKA_3 PF07730.13 VDK87498.1 - 0.016 15.7 2.6 0.016 15.7 2.6 11.6 7 4 4 11 11 11 0 Histidine kinase AAA_34 PF13872.6 VDK87500.1 - 8e-136 451.8 0.0 1.3e-135 451.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Helicase_C_4 PF13871.6 VDK87500.1 - 2.7e-66 224.0 0.1 6e-66 222.9 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue ResIII PF04851.15 VDK87500.1 - 6.3e-06 26.3 0.6 2.5e-05 24.3 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 VDK87500.1 - 0.14 12.5 0.0 0.63 10.4 0.0 2.2 1 0 0 1 1 1 0 Helicase conserved C-terminal domain CDC45 PF02724.14 VDK87500.1 - 4.4 5.5 14.1 8.6 4.5 14.1 1.4 1 0 0 1 1 1 0 CDC45-like protein Pro_sub2 PF18513.1 VDK87501.1 - 0.048 13.8 0.2 0.089 13.0 0.2 1.4 1 0 0 1 1 1 0 Prodomain subtilisin 2 SET PF00856.28 VDK87504.1 - 4.9e-16 59.6 0.3 4.2e-15 56.5 0.0 2.4 2 1 0 2 2 2 1 SET domain Avl9 PF09794.9 VDK87505.1 - 3e-49 167.7 0.0 3.5e-49 167.5 0.0 1.0 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 VDK87505.1 - 1.2e-05 25.1 0.0 1.4e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Afi1 PF07792.12 VDK87505.1 - 0.0052 17.3 0.0 0.0072 16.8 0.0 1.3 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Notch PF00066.17 VDK87507.1 - 1.4e-31 108.7 52.4 4.1e-12 46.3 11.8 3.9 3 0 0 3 3 3 3 LNR domain Ank_2 PF12796.7 VDK87507.1 - 1e-30 106.1 4.8 7.8e-10 39.2 0.1 5.1 2 1 4 6 6 6 4 Ankyrin repeats (3 copies) Ank PF00023.30 VDK87507.1 - 3.5e-23 81.0 5.8 9.4e-07 29.0 0.4 6.8 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 VDK87507.1 - 4.2e-22 78.2 0.4 1.8e-08 34.7 0.3 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK87507.1 - 4.5e-22 75.7 4.1 0.0012 19.2 0.0 7.3 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 VDK87507.1 - 2.7e-21 75.4 1.5 8.2e-08 32.4 0.0 5.1 3 2 2 5 5 5 4 Ankyrin repeats (many copies) NODP PF07684.12 VDK87507.1 - 2.9e-15 56.2 0.0 8.9e-15 54.6 0.0 1.9 1 0 0 1 1 1 1 NOTCH protein NOD PF06816.13 VDK87507.1 - 1.9e-09 37.0 0.1 3.7e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 NOTCH protein EGF PF00008.27 VDK87507.1 - 1.6e-07 31.5 2.6 1.6e-07 31.5 2.6 3.3 2 1 0 2 2 1 1 EGF-like domain hEGF PF12661.7 VDK87507.1 - 2e-06 28.2 5.8 2e-06 28.2 5.8 3.4 2 0 0 2 2 2 1 Human growth factor-like EGF NDUF_B8 PF05821.11 VDK87507.1 - 0.11 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) EGF PF00008.27 VDK87508.1 - 4.3e-16 58.9 16.8 2.1e-10 40.7 4.1 2.9 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 VDK87508.1 - 2.3e-12 47.0 23.0 7.1e-07 29.6 3.7 3.3 3 0 0 3 3 3 2 Human growth factor-like EGF EGF_CA PF07645.15 VDK87508.1 - 5e-06 26.6 24.2 0.00063 19.9 12.1 2.4 1 1 1 2 2 2 2 Calcium-binding EGF domain EGF_2 PF07974.13 VDK87508.1 - 0.00041 20.7 24.7 0.0068 16.7 6.0 2.9 2 1 1 3 3 3 2 EGF-like domain EGF_3 PF12947.7 VDK87508.1 - 0.039 14.1 6.5 0.039 14.1 6.5 3.3 1 1 2 3 3 3 0 EGF domain FXa_inhibition PF14670.6 VDK87508.1 - 0.059 13.7 18.5 0.56 10.5 1.6 3.0 2 1 0 2 2 2 0 Coagulation Factor Xa inhibitory site cEGF PF12662.7 VDK87508.1 - 0.5 10.3 25.0 0.46 10.4 6.5 3.7 3 1 0 3 3 3 0 Complement Clr-like EGF-like EGF_MSP1_1 PF12946.7 VDK87508.1 - 1.1 9.4 21.2 0.26 11.4 9.0 2.5 2 0 0 2 2 2 0 MSP1 EGF domain 1 Laminin_EGF PF00053.24 VDK87508.1 - 1.3 9.3 21.5 1.5 9.0 6.0 2.4 1 1 1 2 2 2 0 Laminin EGF domain CRAL_TRIO PF00650.20 VDK87509.1 - 3.6e-13 49.5 0.1 5.7e-13 48.9 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain RRP36 PF06102.12 VDK87510.1 - 1.5e-36 125.9 19.2 1.5e-36 125.9 19.2 2.4 2 0 0 2 2 2 2 rRNA biogenesis protein RRP36 FHIPEP PF00771.20 VDK87510.1 - 4.5 5.6 4.6 0.85 8.0 1.1 1.5 2 0 0 2 2 2 0 FHIPEP family APG9 PF04109.16 VDK87511.1 - 2.1e-09 37.0 0.1 2.7e-09 36.6 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Septum_form PF13845.6 VDK87513.1 - 0.028 13.9 0.2 0.036 13.6 0.2 1.2 1 0 0 1 1 1 0 Septum formation DUF3458 PF11940.8 VDK87513.1 - 0.046 14.2 2.0 0.067 13.7 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) Ig-like fold Senescence_reg PF04520.13 VDK87513.1 - 0.096 13.5 0.6 0.11 13.3 0.6 1.2 1 0 0 1 1 1 0 Senescence regulator DUF1664 PF07889.12 VDK87517.1 - 0.042 13.9 0.1 0.093 12.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2312 PF10073.9 VDK87517.1 - 0.086 12.5 0.1 0.23 11.1 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) Mur_ligase_M PF08245.12 VDK87517.1 - 0.12 12.4 0.6 0.42 10.6 0.1 2.0 2 0 0 2 2 2 0 Mur ligase middle domain ARD PF03079.14 VDK87517.1 - 0.18 11.9 1.6 0.32 11.2 0.6 2.0 2 0 0 2 2 2 0 ARD/ARD' family SNARE PF05739.19 VDK87518.1 - 1.2e-13 50.8 2.5 3.5e-13 49.3 1.3 2.0 2 0 0 2 2 2 1 SNARE domain TMCO5 PF14992.6 VDK87518.1 - 0.0011 18.6 0.5 0.0016 18.0 0.5 1.3 1 0 0 1 1 1 1 TMCO5 family Synaptobrevin PF00957.21 VDK87518.1 - 0.004 16.9 6.7 0.0066 16.2 6.7 1.4 1 1 0 1 1 1 1 Synaptobrevin Ac76 PF05814.11 VDK87518.1 - 0.02 14.9 1.4 0.028 14.4 1.4 1.3 1 0 0 1 1 1 0 Orf76 (Ac76) Orf78 PF06024.12 VDK87518.1 - 0.04 14.2 0.8 0.047 14.0 0.8 1.2 1 0 0 1 1 1 0 Orf78 (ac78) TraG_N PF07916.11 VDK87518.1 - 0.047 12.6 1.3 0.049 12.5 1.3 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region DUF2116 PF09889.9 VDK87518.1 - 0.73 9.9 4.0 1.1 9.3 4.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PWWP PF00855.17 VDK87519.1 - 2.4e-16 59.9 0.0 5.4e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 PWWP domain FAM76 PF16046.5 VDK87520.1 - 5e-35 121.3 42.8 6.8e-21 74.9 26.2 2.5 1 1 1 2 2 2 2 FAM76 protein TPR_19 PF14559.6 VDK87520.1 - 1.4e-12 48.0 6.5 0.00064 20.2 0.1 5.3 5 1 0 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK87520.1 - 4.7e-12 46.0 4.2 0.015 15.6 1.1 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK87520.1 - 1.6e-11 43.4 20.1 9.7e-05 22.2 1.6 8.7 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 VDK87520.1 - 7.9e-06 25.5 20.9 0.0009 19.0 1.4 7.6 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87520.1 - 1.2e-05 25.2 16.4 0.15 12.3 0.6 7.1 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 VDK87520.1 - 7.6e-05 22.5 15.0 0.029 14.4 0.8 7.5 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 VDK87520.1 - 8.6e-05 22.9 5.1 0.17 12.6 0.3 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK87520.1 - 0.00022 21.8 0.8 0.064 14.1 0.3 4.4 4 1 0 4 4 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK87520.1 - 0.00057 20.5 3.2 4.6 8.0 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK87520.1 - 0.0011 19.1 1.6 0.0011 19.1 1.6 5.1 5 1 1 6 6 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 VDK87520.1 - 0.0024 17.7 1.5 13 5.8 0.0 4.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 VDK87520.1 - 0.01 15.5 9.3 0.081 12.6 1.3 4.1 3 1 1 4 4 4 1 TPR repeat DUF2968 PF11180.8 VDK87520.1 - 0.016 14.9 5.7 0.045 13.4 5.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) BRICHOS PF04089.14 VDK87520.1 - 0.049 13.9 1.7 0.97 9.7 0.1 2.9 2 0 0 2 2 2 0 BRICHOS domain Fis1_TPR_C PF14853.6 VDK87520.1 - 0.11 12.6 0.1 0.11 12.6 0.1 4.9 6 1 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat CCDC92 PF14916.6 VDK87520.1 - 0.11 12.3 13.5 0.061 13.1 5.9 3.1 1 1 0 2 2 2 0 Coiled-coil domain of unknown function PfkB PF00294.24 VDK87520.1 - 0.17 11.1 0.1 0.38 10.0 0.1 1.5 1 0 0 1 1 1 0 pfkB family carbohydrate kinase Phage_Mu_Gam PF07352.12 VDK87520.1 - 0.67 9.8 7.3 0.055 13.4 0.6 2.6 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein Ribosomal_S17e PF00833.18 VDK87521.1 - 3.8e-58 194.7 4.1 4.6e-58 194.5 4.1 1.0 1 0 0 1 1 1 1 Ribosomal S17 Cyclin_N PF00134.23 VDK87522.1 - 4.1e-12 45.9 0.2 5.5e-12 45.5 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF229 PF02995.17 VDK87523.1 - 7.4e-14 51.2 0.2 9.1e-14 50.9 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Branch PF02485.21 VDK87524.1 - 8.8e-43 146.6 0.2 2e-42 145.4 0.0 1.6 2 0 0 2 2 2 1 Core-2/I-Branching enzyme Branch PF02485.21 VDK87525.1 - 4e-27 95.3 0.1 5.6e-27 94.8 0.1 1.2 1 0 0 1 1 1 1 Core-2/I-Branching enzyme CBFD_NFYB_HMF PF00808.23 VDK87526.1 - 2.2e-11 43.9 0.1 4.5e-11 42.9 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK87526.1 - 1.2e-06 29.0 2.7 1.3e-06 28.8 0.2 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 VDK87526.1 - 0.054 13.7 0.2 0.14 12.3 0.2 1.7 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) MFS_1 PF07690.16 VDK87532.1 - 9.5e-05 21.5 0.3 0.00012 21.2 0.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TctB PF07331.11 VDK87532.1 - 0.15 12.3 5.0 0.17 12.2 1.1 2.1 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Yip1 PF04893.17 VDK87532.1 - 0.17 11.6 7.4 2.5 7.8 7.3 2.1 1 1 0 1 1 1 0 Yip1 domain DUF1218 PF06749.12 VDK87532.1 - 0.35 11.4 5.1 3.5 8.2 3.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) DUF4064 PF13273.6 VDK87532.1 - 0.36 11.1 5.2 3.1 8.1 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Phage_holin_3_6 PF07332.11 VDK87532.1 - 0.82 9.7 5.4 0.98 9.5 4.5 1.5 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Ribosomal_S3_C PF00189.20 VDK87533.1 - 7e-23 80.9 1.5 1e-22 80.4 0.8 1.7 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 VDK87533.1 - 5.6e-12 45.3 0.0 9.4e-12 44.6 0.0 1.4 1 0 0 1 1 1 1 KH domain Lysozyme_like PF13702.6 VDK87533.1 - 0.077 12.7 0.2 0.13 12.0 0.2 1.3 1 0 0 1 1 1 0 Lysozyme-like MFS_1 PF07690.16 VDK87535.1 - 4.1e-42 144.4 48.8 1e-41 143.1 33.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SH2 PF00017.24 VDK87541.1 - 7.6e-13 48.4 0.0 2.4e-07 30.8 0.0 2.6 2 0 0 2 2 2 2 SH2 domain SH3_1 PF00018.28 VDK87541.1 - 1.7e-05 24.3 0.0 3.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK87541.1 - 0.0036 17.1 0.0 0.0094 15.8 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 VDK87541.1 - 0.004 17.6 0.2 0.023 15.2 0.1 2.2 2 0 0 2 2 2 1 PH domain RasGAP PF00616.19 VDK87541.1 - 0.012 15.3 1.4 0.023 14.4 0.6 1.8 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase CSTF2_hinge PF14327.6 VDK87541.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.5 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 MADF_DNA_bdg PF10545.9 VDK87542.1 - 1.9e-13 50.5 0.0 5.8e-13 49.0 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 VDK87542.1 - 5.7e-06 26.6 0.2 2.2e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain NatB_MDM20 PF09797.9 VDK87542.1 - 0.0031 16.5 0.2 0.84 8.5 0.4 2.1 2 0 0 2 2 2 2 N-acetyltransferase B complex (NatB) non catalytic subunit Y_phosphatase PF00102.27 VDK87544.1 - 6e-68 228.9 0.5 4.5e-36 124.6 0.2 2.2 1 1 1 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 VDK87544.1 - 4.2e-05 23.4 0.1 0.00011 22.0 0.1 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK87544.1 - 0.00085 19.4 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family Phi-29_GP16_7 PF06720.11 VDK87544.1 - 0.0058 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Bacteriophage phi-29 early protein GP16.7 PTPlike_phytase PF14566.6 VDK87544.1 - 0.078 13.1 0.1 0.23 11.6 0.0 1.9 2 1 0 2 2 2 0 Inositol hexakisphosphate Phosphodiest PF01663.22 VDK87545.1 - 2.4e-70 237.9 0.2 3e-70 237.6 0.2 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Endonuclease_NS PF01223.23 VDK87545.1 - 8.9e-05 22.4 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Metalloenzyme PF01676.18 VDK87545.1 - 0.00047 19.6 0.0 0.00081 18.8 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphoesterase PF04185.14 VDK87545.1 - 0.006 15.8 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoesterase family LapA_dom PF06305.11 VDK87545.1 - 0.13 12.1 0.7 0.27 11.1 0.7 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Pkinase PF00069.25 VDK87546.1 - 6.6e-33 114.2 0.1 4.2e-30 105.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87546.1 - 1.8e-16 60.2 0.0 4.1e-16 59.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK87546.1 - 6.3e-09 35.5 0.0 8.4e-09 35.2 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK87546.1 - 0.00044 19.7 0.4 0.025 13.9 0.1 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family zf-CCHC_3 PF13917.6 VDK87552.1 - 4e-05 23.5 1.1 4e-05 23.5 1.1 2.0 1 1 1 2 2 2 1 Zinc knuckle SelP_N PF04592.14 VDK87552.1 - 0.062 12.7 10.3 0.071 12.5 10.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RNA_polI_A34 PF08208.11 VDK87552.1 - 0.98 9.5 19.3 1.3 9.1 19.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Presenilin PF01080.17 VDK87552.1 - 8.4 5.0 6.0 10 4.8 6.0 1.1 1 0 0 1 1 1 0 Presenilin F-box_5 PF18511.1 VDK87553.1 - 0.18 11.4 0.8 0.45 10.1 0.4 1.9 2 0 0 2 2 2 0 F-box Pex2_Pex12 PF04757.14 VDK87554.1 - 7.3e-15 55.2 1.0 1.3e-14 54.4 1.0 1.4 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 VDK87554.1 - 1.1e-05 25.2 0.6 2e-05 24.4 0.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 VDK87554.1 - 5.6e-05 22.9 1.5 8.2e-05 22.4 0.4 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK87554.1 - 9.2e-05 22.7 0.4 0.00019 21.7 0.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 VDK87554.1 - 0.013 15.7 1.6 0.038 14.1 1.6 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 VDK87554.1 - 0.017 15.0 3.8 0.094 12.6 3.8 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Gag_p17 PF00540.18 VDK87554.1 - 0.063 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) zf-rbx1 PF12678.7 VDK87554.1 - 0.1 12.9 1.3 0.57 10.5 1.3 2.0 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 VDK87554.1 - 0.13 12.3 1.2 0.37 10.9 1.2 1.8 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 VDK87554.1 - 0.22 11.4 1.7 4.9 7.1 1.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 VDK87554.1 - 0.45 10.5 2.2 1.6 8.7 2.2 1.9 1 1 0 1 1 1 0 zinc-RING finger domain PHR PF08005.12 VDK87555.1 - 1.9e-20 74.1 0.0 3.1e-20 73.4 0.0 1.4 1 0 0 1 1 1 1 PHR domain BTB PF00651.31 VDK87555.1 - 3.1e-11 43.5 0.3 2.2e-08 34.3 0.0 3.0 2 1 1 3 3 3 2 BTB/POZ domain BACK PF07707.15 VDK87555.1 - 7.5e-08 32.4 0.0 2.1e-07 31.0 0.0 1.7 2 0 0 2 2 2 1 BTB And C-terminal Kelch Diphthamide_syn PF01866.17 VDK87556.1 - 4.3e-71 239.8 0.0 5.5e-71 239.5 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Leader_CPA1 PF08252.11 VDK87556.1 - 0.0073 15.7 0.0 0.097 12.1 0.0 2.4 2 0 0 2 2 2 1 arg-2/CPA1 leader peptide Hist_deacetyl PF00850.19 VDK87557.1 - 1.5e-81 274.3 0.0 1.8e-81 274.0 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain zf-BED PF02892.15 VDK87559.1 - 0.0089 16.0 15.9 1.2 9.3 0.0 5.5 6 0 0 6 6 6 4 BED zinc finger TMF_TATA_bd PF12325.8 VDK87560.1 - 6.4e-13 48.9 27.6 1.8e-12 47.5 6.1 3.0 2 1 1 3 3 3 2 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.9 VDK87560.1 - 3.4e-05 23.9 29.1 0.00022 21.2 7.3 2.3 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IFT57 PF10498.9 VDK87560.1 - 0.00035 19.7 18.9 0.0023 16.9 9.6 2.0 2 0 0 2 2 2 2 Intra-flagellar transport protein 57 PKcGMP_CC PF16808.5 VDK87560.1 - 0.12 12.3 0.6 0.12 12.3 0.6 3.9 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Pox_A11 PF05061.13 VDK87560.1 - 0.18 11.1 5.2 0.29 10.4 4.5 1.6 1 1 1 2 2 2 0 Poxvirus A11 Protein XLF PF09302.11 VDK87560.1 - 0.22 11.7 6.6 0.078 13.1 2.5 2.3 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF948 PF06103.11 VDK87560.1 - 0.24 11.7 4.1 0.59 10.4 0.7 2.7 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.5 VDK87560.1 - 0.25 11.6 18.2 0.23 11.7 4.4 3.2 2 1 1 3 3 3 0 ABC transporter C-terminal domain ADIP PF11559.8 VDK87560.1 - 0.3 11.2 21.4 0.035 14.2 9.2 2.9 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding HemX PF04375.14 VDK87560.1 - 0.56 9.4 12.6 1.2 8.4 4.4 2.7 2 1 1 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase LPP20 PF02169.16 VDK87560.1 - 0.76 10.2 6.4 0.12 12.7 1.3 2.2 2 1 1 3 3 3 0 LPP20 lipoprotein TMPIT PF07851.13 VDK87560.1 - 1.2 8.3 11.6 0.68 9.1 0.7 2.2 2 0 0 2 2 2 0 TMPIT-like protein WEMBL PF05701.11 VDK87560.1 - 1.2 7.7 18.0 0.24 10.1 9.1 2.1 2 0 0 2 2 2 0 Weak chloroplast movement under blue light DUF2203 PF09969.9 VDK87560.1 - 1.9 9.2 10.9 3.2 8.5 2.0 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF4407 PF14362.6 VDK87560.1 - 2.9 7.2 8.5 15 4.9 8.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TSC22 PF01166.18 VDK87560.1 - 5.1 7.5 11.8 4.4 7.7 2.1 3.6 2 1 1 3 3 3 0 TSC-22/dip/bun family ERM PF00769.19 VDK87560.1 - 5.9 6.6 22.3 83 2.9 22.1 2.1 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF2779 PF11074.8 VDK87560.1 - 8 7.0 6.5 4.6 7.7 0.9 2.5 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) Atg14 PF10186.9 VDK87560.1 - 9.4 5.2 15.0 0.39 9.7 0.2 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Pkinase PF00069.25 VDK87561.1 - 2.4e-54 184.5 0.0 2.7e-54 184.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87561.1 - 1.8e-29 102.8 0.0 2.5e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDK87561.1 - 9.6e-08 31.4 0.1 1.2e-07 31.0 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 VDK87561.1 - 9.1e-05 21.9 0.0 0.011 15.0 0.0 2.3 1 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 VDK87561.1 - 0.00014 20.8 0.0 0.00025 19.9 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 VDK87561.1 - 0.00019 20.9 0.1 0.0003 20.2 0.1 1.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 VDK87561.1 - 0.016 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 VDK87561.1 - 0.027 14.1 0.1 2 8.0 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 VDK87561.1 - 0.03 14.2 0.0 0.067 13.1 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 VDK87561.1 - 0.083 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL TMF_DNA_bd PF12329.8 VDK87562.1 - 1.5e-05 24.9 14.2 1.5e-05 24.9 14.2 6.6 2 1 4 6 6 6 2 TATA element modulatory factor 1 DNA binding Baculo_PEP_C PF04513.12 VDK87562.1 - 0.44 10.6 20.4 0.11 12.6 4.4 3.6 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus PolyA_pol PF01743.20 VDK87562.1 - 1.2 9.6 10.7 0.41 11.1 0.5 3.1 1 1 1 3 3 3 0 Poly A polymerase head domain Chrome_Resist PF09828.9 VDK87562.1 - 5.2 7.5 6.9 0.87 10.0 0.2 2.9 3 1 1 4 4 4 0 Chromate resistance exported protein RhoGAP PF00620.27 VDK87563.1 - 3e-41 140.8 0.0 6.9e-41 139.6 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 VDK87563.1 - 3.5e-12 46.4 4.0 2.8e-11 43.5 4.5 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Laminin_G_3 PF13385.6 VDK87567.1 - 0.00044 20.4 0.0 0.00093 19.4 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily E3_UbLigase_R4 PF13764.6 VDK87567.1 - 0.023 12.9 0.1 0.48 8.5 0.0 2.3 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase UBR4 DUF3361 PF11841.8 VDK87567.1 - 1.4 8.8 7.9 13 5.7 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3361) NOA36 PF06524.12 VDK87573.1 - 0.001 18.4 16.2 0.0011 18.4 16.2 1.1 1 0 0 1 1 1 1 NOA36 protein CDC45 PF02724.14 VDK87573.1 - 0.058 11.7 8.5 0.06 11.6 8.5 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 VDK87573.1 - 0.094 11.8 22.9 0.094 11.8 22.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CobT PF06213.12 VDK87573.1 - 0.47 9.8 10.0 0.52 9.7 10.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PPP4R2 PF09184.11 VDK87573.1 - 0.47 10.0 11.2 0.5 9.9 11.2 1.1 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 VDK87573.1 - 0.58 8.2 20.5 0.61 8.1 20.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 VDK87573.1 - 0.93 8.9 12.1 1.1 8.7 12.1 1.1 1 0 0 1 1 1 0 SDA1 RNA_pol_3_Rpc31 PF11705.8 VDK87573.1 - 2 8.6 19.4 2.3 8.4 19.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 VDK87573.1 - 2.7 6.1 12.3 2.5 6.2 12.3 1.1 1 0 0 1 1 1 0 Nop14-like family TPK_catalytic PF04263.16 VDK87574.1 - 0.11 12.5 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain TRP_2 PF08344.11 VDK87579.1 - 3.1e-26 91.3 4.8 6.3e-26 90.4 4.8 1.5 1 0 0 1 1 1 1 Transient receptor ion channel II Ank_2 PF12796.7 VDK87579.1 - 1.2e-12 48.3 2.5 1.5e-07 31.9 0.3 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK87579.1 - 9.1e-10 38.9 4.4 0.00091 19.7 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK87579.1 - 2.2e-08 33.7 5.1 0.0046 17.4 0.1 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 VDK87579.1 - 2.7e-08 33.9 1.6 0.0009 19.5 0.2 3.3 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 VDK87579.1 - 6.1e-06 26.5 3.8 0.084 13.4 0.3 3.1 2 1 0 2 2 2 2 Ankyrin repeat DUF3447 PF11929.8 VDK87579.1 - 0.03 14.3 0.3 0.03 14.3 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3447) LRR19-TM PF15176.6 VDK87579.1 - 0.064 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain F-box-like PF12937.7 VDK87583.1 - 1.4e-06 28.1 0.6 3.8e-06 26.7 0.6 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 VDK87583.1 - 8.9e-05 22.3 0.5 8.9e-05 22.3 0.5 2.4 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 VDK87583.1 - 0.36 11.3 18.6 52 4.5 0.1 6.9 3 3 5 8 8 8 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 VDK87583.1 - 1.7 8.9 4.4 99 3.4 0.0 4.8 5 0 0 5 5 5 0 Leucine Rich repeat EF-hand_1 PF00036.32 VDK87584.1 - 1.2e-22 77.7 11.0 3.5e-07 29.3 0.5 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 VDK87584.1 - 1.3e-21 76.8 8.4 1.1e-10 41.8 0.3 2.8 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 VDK87584.1 - 3.7e-20 70.1 6.7 1.5e-06 27.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 VDK87584.1 - 3e-15 55.8 7.2 4.6e-06 26.4 0.5 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_9 PF14658.6 VDK87584.1 - 1.3e-11 44.7 0.2 5.9e-08 32.9 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 VDK87584.1 - 1.7e-08 33.6 7.6 0.00029 20.2 0.1 3.7 4 1 0 4 4 4 2 EF hand EF-hand_4 PF12763.7 VDK87584.1 - 5.9e-07 29.4 2.8 0.0089 16.0 0.2 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDK87584.1 - 0.0023 18.3 0.6 0.73 10.2 0.2 2.7 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 VDK87584.1 - 0.0057 17.0 0.1 0.015 15.6 0.1 1.7 1 1 0 1 1 1 1 EF-hand domain EF-hand_11 PF08976.11 VDK87584.1 - 0.011 16.6 0.1 0.067 14.1 0.0 2.0 1 1 1 2 2 2 0 EF-hand domain TerB PF05099.13 VDK87584.1 - 0.016 15.2 0.1 0.051 13.5 0.0 1.8 1 1 1 2 2 2 0 Tellurite resistance protein TerB DUF2408 PF10303.9 VDK87584.1 - 0.15 12.6 0.0 0.23 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) C6 PF01681.17 VDK87585.1 - 2.7e-18 66.3 69.9 2.6e-05 24.7 2.3 7.4 6 1 0 6 6 6 5 C6 domain Endotoxin_mid PF09131.10 VDK87585.1 - 0.00075 19.2 7.1 2.8 7.6 0.0 4.7 5 0 0 5 5 5 2 Bacillus thuringiensis delta-Endotoxin, middle domain Arylesterase PF01731.20 VDK87585.1 - 0.0033 17.6 0.0 1e+02 3.2 0.0 4.2 4 0 0 4 4 4 0 Arylesterase HCV_NS4a PF01006.20 VDK87585.1 - 0.23 11.3 3.2 1.8 8.4 3.2 2.6 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a Churchill PF06573.11 VDK87585.1 - 2 8.8 11.0 34 4.8 0.1 4.8 5 0 0 5 5 5 0 Churchill protein LRR_8 PF13855.6 VDK87586.1 - 4.2e-07 29.6 0.0 1.4e-06 27.9 0.0 1.7 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 VDK87586.1 - 0.00054 20.3 0.0 0.0024 18.2 0.0 1.8 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDK87586.1 - 0.021 14.3 0.0 0.37 10.3 0.0 1.9 1 1 1 2 2 2 0 Leucine-rich repeat DHHC PF01529.20 VDK87587.1 - 1.1e-26 93.6 15.9 1.1e-26 93.6 15.9 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase FERM_M PF00373.18 VDK87588.1 - 3.4e-17 62.9 0.1 1e-16 61.4 0.1 1.9 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 VDK87588.1 - 2.1e-13 50.0 0.2 4.8e-13 48.9 0.2 1.7 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 VDK87588.1 - 3.3e-11 43.4 0.4 9.2e-11 42.0 0.4 1.7 1 1 0 1 1 1 1 FERM C-terminal PH-like domain FA PF08736.11 VDK87588.1 - 0.41 10.8 2.9 3.3 7.9 2.9 2.5 1 1 0 1 1 1 0 FERM adjacent (FA) RNA_pol_Rpb2_6 PF00562.28 VDK87595.1 - 7.3e-124 413.8 0.1 7.4e-123 410.5 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 VDK87595.1 - 9.7e-46 155.8 0.2 1.7e-45 155.1 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 VDK87595.1 - 4.5e-35 119.9 0.6 1.1e-34 118.7 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 VDK87595.1 - 2.3e-24 86.1 0.1 4.2e-24 85.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 VDK87595.1 - 1.4e-20 73.2 0.0 3.4e-20 72.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 VDK87595.1 - 8.6e-12 45.2 0.0 3.2e-11 43.4 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 VDK87595.1 - 3.7e-09 37.0 0.4 1.1e-08 35.5 0.4 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Lar_N PF09861.9 VDK87595.1 - 0.093 11.9 0.0 0.41 9.8 0.0 1.9 2 0 0 2 2 2 0 Lactate racemase N-terminal domain DUF1398 PF07166.11 VDK87595.1 - 0.17 11.9 0.2 6.1 6.9 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1398) CD36 PF01130.21 VDK87596.1 - 7.3e-112 374.3 0.0 8.4e-112 374.1 0.0 1.0 1 0 0 1 1 1 1 CD36 family Pkinase PF00069.25 VDK87602.1 - 2.1e-61 207.6 0.0 3e-61 207.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CNH PF00780.22 VDK87602.1 - 3.4e-54 184.3 0.0 4.9e-54 183.8 0.0 1.2 1 0 0 1 1 1 1 CNH domain Pkinase_Tyr PF07714.17 VDK87602.1 - 2.1e-44 151.8 0.0 3.3e-44 151.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK87602.1 - 7.5e-06 25.0 0.0 9.1e-05 21.4 0.0 2.4 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 VDK87602.1 - 0.00076 18.9 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 VDK87602.1 - 0.035 13.7 0.4 0.46 10.1 0.1 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 VDK87602.1 - 0.11 11.4 0.1 0.19 10.6 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Collagen PF01391.18 VDK87616.1 - 9e-25 86.2 117.2 1e-09 38.0 38.4 4.1 1 1 3 4 4 4 4 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK87616.1 - 2e-22 79.0 1.6 3.3e-22 78.3 1.6 1.4 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain TPR_2 PF07719.17 VDK87617.1 - 3.4e-20 70.4 5.1 2.3e-08 33.6 0.0 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 VDK87617.1 - 1.1e-19 69.3 7.2 4.6e-09 35.7 0.0 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 VDK87617.1 - 8.5e-19 67.0 4.5 3.2e-07 29.9 0.8 8.2 8 1 1 9 9 9 4 TPR repeat TPR_14 PF13428.6 VDK87617.1 - 2.3e-18 65.3 10.6 5.7e-05 23.6 0.0 7.8 4 2 4 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87617.1 - 1.1e-17 62.7 5.9 2.4e-08 33.5 0.0 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 VDK87617.1 - 4.5e-17 62.3 9.0 3.3e-05 24.3 0.0 5.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 VDK87617.1 - 8.2e-16 57.2 9.6 0.024 15.0 0.0 9.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 VDK87617.1 - 6.6e-15 55.5 0.3 8e-06 26.4 0.0 5.1 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 VDK87617.1 - 9.8e-09 35.3 5.7 0.1 13.3 0.0 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 VDK87617.1 - 3.7e-08 33.4 3.4 0.00027 21.0 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 VDK87617.1 - 3.9e-07 30.3 10.2 8.8e-05 22.7 0.4 6.1 5 2 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK87617.1 - 9.3e-07 29.0 12.0 0.057 13.6 0.0 5.5 3 1 4 7 7 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 VDK87617.1 - 7.8e-06 25.6 0.1 0.0036 17.2 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 VDK87617.1 - 5.8e-05 23.3 2.9 0.29 11.5 0.4 3.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 VDK87617.1 - 0.00021 21.0 2.4 0.00022 21.0 0.1 2.1 4 0 0 4 4 2 1 Tetratricopeptide repeat-like domain TPR_15 PF13429.6 VDK87617.1 - 0.00038 19.8 9.8 0.026 13.8 0.0 4.3 2 2 2 4 4 4 1 Tetratricopeptide repeat BTAD PF03704.17 VDK87617.1 - 0.0021 18.5 0.7 0.035 14.5 0.0 2.5 1 1 1 2 2 2 1 Bacterial transcriptional activator domain PPR PF01535.20 VDK87617.1 - 0.0052 17.0 0.1 0.064 13.5 0.0 2.9 3 0 0 3 3 2 1 PPR repeat TPR_MalT PF17874.1 VDK87617.1 - 0.045 13.1 2.0 0.051 12.9 0.3 1.9 2 0 0 2 2 2 0 MalT-like TPR region TPR_10 PF13374.6 VDK87617.1 - 0.094 12.6 3.9 0.67 9.9 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 VDK87617.1 - 0.14 12.9 0.1 1.8 9.3 0.0 2.9 2 0 0 2 2 2 0 Sel1 repeat NDUF_B4 PF07225.12 VDK87618.1 - 2.2e-33 114.8 0.2 4.3e-33 113.9 0.2 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) TPR_1 PF00515.28 VDK87618.1 - 0.002 17.9 1.1 0.89 9.5 0.3 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK87618.1 - 0.047 13.8 5.1 2 8.7 0.3 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87618.1 - 0.098 12.9 2.1 1.3 9.4 0.4 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 VDK87618.1 - 0.11 12.2 1.6 0.37 10.5 1.1 2.2 1 1 0 1 1 1 0 TPR repeat TPR_14 PF13428.6 VDK87618.1 - 0.14 13.0 1.6 94 4.2 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK87618.1 - 0.21 12.1 8.4 1.4 9.5 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat RhoGEF PF00621.20 VDK87623.1 - 4.6e-20 72.6 5.1 9.4e-20 71.6 3.8 2.2 2 0 0 2 2 2 1 RhoGEF domain RBD PF02196.15 VDK87623.1 - 0.0013 18.7 0.1 0.0037 17.3 0.1 1.8 1 0 0 1 1 1 1 Raf-like Ras-binding domain TUG-UBL1 PF11470.8 VDK87623.1 - 0.018 15.2 0.1 0.75 10.1 0.0 2.5 2 0 0 2 2 2 0 TUG ubiquitin-like domain PDZ PF00595.24 VDK87623.1 - 0.03 14.7 0.0 0.082 13.3 0.0 1.8 1 0 0 1 1 1 0 PDZ domain UL41A PF17591.2 VDK87623.1 - 0.094 12.8 0.1 0.21 11.7 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus UL41A Histone_HNS PF00816.21 VDK87623.1 - 0.13 13.1 0.3 0.47 11.3 0.3 2.0 1 0 0 1 1 1 0 H-NS histone family NPV_P10 PF05531.12 VDK87623.1 - 0.41 11.2 0.1 0.41 11.2 0.1 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 VDK87623.1 - 1.2 9.3 4.7 25 5.1 0.1 3.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Hph PF13694.6 VDK87623.1 - 3.4 7.9 8.8 0.059 13.7 0.6 2.3 3 0 0 3 3 3 0 Sec63/Sec62 complex-interacting family ANAPC4 PF12896.7 VDK87623.1 - 4.8 6.6 11.5 0.42 10.1 0.8 3.4 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 4 zf-UBR PF02207.20 VDK87628.1 - 2.9e-17 62.6 11.8 2.9e-17 62.6 11.8 2.4 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) PCI PF01399.27 VDK87629.1 - 1.1e-16 61.3 1.6 3.5e-16 59.6 0.0 2.6 3 0 0 3 3 3 1 PCI domain RPN5_C PF18098.1 VDK87629.1 - 5.5e-10 39.2 0.7 1.6e-09 37.7 0.7 1.9 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Mdv1 PF11542.8 VDK87630.1 - 0.13 12.2 0.3 0.13 12.2 0.3 1.9 3 0 0 3 3 3 0 Mitochondrial division protein 1 FAM60A PF15396.6 VDK87630.1 - 2.3 8.2 12.0 3 7.8 12.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A TAFII28 PF04719.14 VDK87636.1 - 1e-30 105.6 0.0 1.8e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 hTAFII28-like protein conserved region PPI_Ypi1 PF07491.11 VDK87636.1 - 0.1 12.5 0.7 0.26 11.1 0.7 1.7 1 0 0 1 1 1 0 Protein phosphatase inhibitor GDP_Man_Dehyd PF16363.5 VDK87637.1 - 5.6e-13 49.0 0.3 4.2e-12 46.1 0.1 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 VDK87637.1 - 1.9e-10 40.6 0.3 2.2e-08 33.9 0.0 2.8 3 0 0 3 3 3 2 NAD dependent epimerase/dehydratase family Orn_Arg_deC_N PF02784.16 VDK87638.1 - 4e-31 108.3 0.0 5.4e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 VDK87638.1 - 8.1e-07 29.2 0.0 1.3e-06 28.5 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF1479 PF07350.12 VDK87638.1 - 0.12 11.2 0.0 0.17 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) LRR_6 PF13516.6 VDK87640.1 - 0.0046 16.9 2.0 0.57 10.4 0.0 4.1 4 0 0 4 4 4 1 Leucine Rich repeat CLN3 PF02487.17 VDK87641.1 - 2.2e-130 435.3 14.1 2.7e-130 435.0 14.1 1.0 1 0 0 1 1 1 1 CLN3 protein TPR_2 PF07719.17 VDK87643.1 - 2.5e-10 39.7 2.3 0.00059 19.7 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_C PF00254.28 VDK87643.1 - 1.8e-08 34.6 0.0 3.9e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 VDK87643.1 - 6.2e-08 32.1 4.1 0.0038 17.0 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK87643.1 - 1.1e-05 25.8 0.1 0.0049 17.6 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK87643.1 - 0.0097 16.2 1.5 41 4.6 0.0 3.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 VDK87643.1 - 0.0099 15.5 9.3 0.2 11.3 1.0 3.1 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 VDK87643.1 - 0.013 16.0 0.8 0.031 14.8 0.5 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK87643.1 - 0.035 14.3 4.1 0.39 11.0 0.5 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Pilus_CpaD PF09476.10 VDK87643.1 - 0.11 12.1 0.4 0.18 11.5 0.4 1.4 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) TPR_8 PF13181.6 VDK87643.1 - 0.52 10.7 3.2 11 6.6 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Voltage_CLC PF00654.20 VDK87646.1 - 3.5e-48 164.7 15.0 6.5e-38 130.9 3.6 2.2 1 1 1 2 2 2 2 Voltage gated chloride channel DUF2198 PF09964.9 VDK87646.1 - 0.049 13.7 0.2 0.19 11.8 0.2 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2198) CBS PF00571.28 VDK87646.1 - 0.19 12.2 0.1 5.3 7.6 0.0 2.9 3 0 0 3 3 3 0 CBS domain Phage_TAC_4 PF08748.11 VDK87646.1 - 0.34 11.2 1.2 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 Phage tail assembly chaperone BTB PF00651.31 VDK87648.1 - 0.025 14.8 0.0 0.056 13.7 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain Phage_TAC_4 PF08748.11 VDK87648.1 - 0.15 12.4 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone Aminotran_5 PF00266.19 VDK87650.1 - 9.4e-27 93.9 0.1 1.1e-26 93.7 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-V VEFS-Box PF09733.9 VDK87652.1 - 2.6e-16 59.7 2.1 6.1e-16 58.5 2.1 1.6 1 0 0 1 1 1 1 VEFS-Box of polycomb protein Claudin_2 PF13903.6 VDK87654.1 - 1.2e-09 38.2 0.1 1.2e-09 38.2 0.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Tetraspanin PF00335.20 VDK87654.1 - 0.031 14.0 0.2 0.043 13.5 0.2 1.2 1 0 0 1 1 1 0 Tetraspanin family SKICH PF17751.1 VDK87657.1 - 2.8e-07 31.0 0.4 3.8e-07 30.6 0.4 1.2 1 0 0 1 1 1 1 SKICH domain DUF3335 PF11814.8 VDK87657.1 - 0.016 14.7 0.2 0.019 14.4 0.2 1.1 1 0 0 1 1 1 0 Peptidase_C39 like family PI3_PI4_kinase PF00454.27 VDK87659.1 - 3e-41 141.9 0.3 8.4e-39 133.9 0.3 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 VDK87659.1 - 6.3e-26 90.9 0.4 2.8e-25 88.8 0.0 2.3 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 VDK87659.1 - 0.034 13.5 0.0 0.07 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Copine PF07002.16 VDK87661.1 - 1.7e-40 138.8 0.0 2.6e-40 138.2 0.0 1.2 1 0 0 1 1 1 1 Copine Pyr_redox_2 PF07992.14 VDK87662.1 - 1.6e-50 172.0 0.0 4.7e-50 170.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 VDK87662.1 - 3.2e-26 91.7 0.1 1.2e-25 89.9 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 VDK87662.1 - 9.3e-16 58.2 2.2 3.5e-12 46.7 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 VDK87662.1 - 3.8e-07 29.7 0.0 0.00029 20.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 VDK87662.1 - 3.5e-05 23.2 0.0 0.0013 18.1 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 VDK87662.1 - 9.2e-05 22.0 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 VDK87662.1 - 0.0001 21.5 2.8 0.00017 20.8 2.8 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 VDK87662.1 - 0.0053 16.0 0.1 0.0095 15.2 0.1 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 VDK87662.1 - 0.013 15.1 0.1 0.049 13.2 0.1 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 VDK87662.1 - 0.021 13.9 0.9 0.033 13.3 0.9 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_8 PF13450.6 VDK87662.1 - 0.029 14.6 0.5 0.029 14.6 0.5 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 VDK87662.1 - 0.061 12.0 0.4 0.11 11.2 0.4 1.4 1 0 0 1 1 1 0 HI0933-like protein RVT_connect PF06815.13 VDK87662.1 - 0.11 12.7 0.0 0.3 11.4 0.0 1.7 1 0 0 1 1 1 0 Reverse transcriptase connection domain K_oxygenase PF13434.6 VDK87662.1 - 0.14 11.3 0.0 0.72 8.9 0.0 2.0 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) 7TM_GPCR_Srw PF10324.9 VDK87665.1 - 3.4e-18 66.0 2.5 1.3e-17 64.1 2.5 1.8 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7tm_1 PF00001.21 VDK87665.1 - 0.0021 17.5 1.3 0.0054 16.1 1.3 1.8 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Zona_pellucida PF00100.23 VDK87666.1 - 2.7e-11 43.7 5.1 4e-11 43.2 5.1 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Mito_fiss_reg PF05308.11 VDK87666.1 - 0.48 10.5 14.4 0.76 9.8 14.4 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 VDK87666.1 - 0.51 9.8 13.5 0.85 9.0 13.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 VDK87666.1 - 9.6 6.3 14.0 31 4.6 14.0 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mlf1IP PF10248.9 VDK87670.1 - 5.8e-40 137.1 5.8 9.7e-40 136.3 5.8 1.3 1 0 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein SNF PF00209.18 VDK87671.1 - 7.4e-09 34.8 0.1 7.4e-09 34.8 0.1 3.2 3 2 0 3 3 3 1 Sodium:neurotransmitter symporter family EF-hand_7 PF13499.6 VDK87674.1 - 5e-28 97.3 6.8 1.4e-13 51.1 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 VDK87674.1 - 9.5e-27 90.5 8.6 8.7e-07 28.1 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 VDK87674.1 - 6.1e-24 81.9 1.4 0.0002 21.0 0.0 4.1 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 VDK87674.1 - 8.8e-19 67.1 6.8 3.6e-05 23.5 0.4 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 VDK87674.1 - 9.9e-19 65.9 6.4 1.5e-05 24.3 0.1 4.2 4 0 0 4 4 4 4 EF hand SPARC_Ca_bdg PF10591.9 VDK87674.1 - 9.4e-09 35.6 0.2 0.0018 18.6 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 VDK87674.1 - 1.3e-06 28.6 0.7 0.0012 19.2 0.0 2.6 2 1 1 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 VDK87674.1 - 3e-06 27.1 2.3 0.015 15.2 0.1 2.3 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 VDK87674.1 - 0.0047 17.8 0.9 4.3 8.3 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain Caleosin PF05042.13 VDK87674.1 - 0.0055 16.7 0.8 0.11 12.4 0.0 3.0 1 1 3 4 4 4 1 Caleosin related protein gp45-slide_C PF09116.10 VDK87674.1 - 0.046 13.8 0.1 0.078 13.0 0.1 1.4 1 0 0 1 1 1 0 gp45 sliding clamp, C terminal BTG PF07742.12 VDK87676.1 - 2e-19 69.6 0.0 3.2e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 BTG family ThiF PF00899.21 VDK87680.1 - 5e-33 114.5 0.0 7.5e-33 113.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family Adhesin_E PF16747.5 VDK87680.1 - 0.015 15.3 0.1 0.03 14.4 0.1 1.4 1 0 0 1 1 1 0 Surface-adhesin protein E AAA_5 PF07728.14 VDK87681.1 - 8.8e-114 375.6 0.0 6.1e-26 91.1 0.0 8.8 8 1 0 8 8 8 8 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 VDK87681.1 - 1.2e-32 112.5 0.0 1.9e-07 31.0 0.0 7.8 7 1 0 7 7 7 4 ATPase family associated with various cellular activities (AAA) AAA_lid_7 PF17867.1 VDK87681.1 - 2.4e-31 108.1 11.8 4e-10 39.8 0.2 4.9 5 0 0 5 5 4 3 Midasin AAA lid domain AAA PF00004.29 VDK87681.1 - 6.9e-30 104.2 0.2 6e-05 23.5 0.0 7.1 7 0 0 7 7 6 5 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 VDK87681.1 - 8.8e-25 88.0 5.9 0.00023 21.6 0.1 7.5 7 2 0 8 8 6 6 AAA ATPase domain AAA_7 PF12775.7 VDK87681.1 - 5.5e-24 84.7 5.9 0.0001 21.9 0.0 7.0 7 0 0 7 7 6 6 P-loop containing dynein motor region ABC_tran PF00005.27 VDK87681.1 - 1.1e-20 74.5 0.9 0.00011 22.7 0.0 6.5 6 0 0 6 6 6 3 ABC transporter Dynein_heavy PF03028.15 VDK87681.1 - 6.9e-20 71.3 0.0 0.00041 20.4 0.0 6.4 6 1 0 6 6 5 3 Dynein heavy chain region D6 P-loop domain Rad17 PF03215.15 VDK87681.1 - 1.2e-17 64.4 7.8 0.0041 17.1 0.1 6.8 6 0 0 6 6 6 4 Rad17 P-loop domain AAA_14 PF13173.6 VDK87681.1 - 7.8e-17 61.5 0.0 0.0088 16.1 0.0 7.2 7 0 0 7 7 7 2 AAA domain Sigma54_activat PF00158.26 VDK87681.1 - 1e-16 61.1 0.5 0.0032 17.2 0.0 7.5 7 2 0 7 7 6 3 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 VDK87681.1 - 1.2e-16 61.0 0.2 0.0023 18.1 0.0 6.9 7 0 0 7 7 6 2 Sigma-54 interaction domain RNA_helicase PF00910.22 VDK87681.1 - 3.4e-16 59.5 2.3 0.35 11.3 0.0 7.2 6 0 0 6 6 6 3 RNA helicase AAA_18 PF13238.6 VDK87681.1 - 1.1e-15 58.3 1.0 0.37 11.3 0.0 7.0 7 0 0 7 7 6 4 AAA domain AAA_30 PF13604.6 VDK87681.1 - 3.3e-15 56.3 0.1 0.037 13.7 0.0 7.7 7 2 0 7 7 7 2 AAA domain AAA_6 PF12774.7 VDK87681.1 - 4.6e-15 55.4 6.2 0.016 14.2 0.0 9.7 9 2 0 9 9 9 2 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 VDK87681.1 - 8.6e-15 55.2 6.4 0.037 14.3 0.0 7.5 8 0 0 8 8 5 3 AAA domain TsaE PF02367.17 VDK87681.1 - 8.9e-14 51.6 4.0 0.042 13.8 0.0 6.3 6 0 0 6 6 6 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_lid_5 PF17865.1 VDK87681.1 - 5.3e-13 49.0 1.3 3.2e-12 46.5 0.9 2.5 2 1 0 2 2 1 1 Midasin AAA lid domain Mg_chelatase PF01078.21 VDK87681.1 - 6e-12 45.4 4.4 1.8 7.9 0.0 8.2 8 1 1 9 9 8 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 VDK87681.1 - 6.6e-12 45.7 10.0 0.19 11.6 0.1 6.6 6 0 0 6 6 6 3 NACHT domain Viral_helicase1 PF01443.18 VDK87681.1 - 1.4e-11 44.6 0.2 0.11 12.3 0.0 6.1 6 0 0 6 6 6 2 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 VDK87681.1 - 1.2e-10 41.4 4.8 0.26 11.0 0.0 6.9 7 1 0 7 7 6 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 VDK87681.1 - 3e-10 40.4 0.9 3 8.0 0.0 7.2 7 1 0 7 7 7 0 AAA domain Zeta_toxin PF06414.12 VDK87681.1 - 4.6e-10 39.1 0.3 0.27 10.5 0.0 6.2 6 0 0 6 6 6 2 Zeta toxin AAA_23 PF13476.6 VDK87681.1 - 5.2e-10 40.2 3.1 0.073 13.6 0.0 6.1 6 0 0 6 6 6 1 AAA domain AAA_29 PF13555.6 VDK87681.1 - 6e-10 38.7 1.9 1.5 8.6 0.1 6.4 6 0 0 6 6 6 2 P-loop containing region of AAA domain T2SSE PF00437.20 VDK87681.1 - 3e-09 36.3 1.4 2.8 6.9 0.1 6.2 6 0 0 6 6 6 0 Type II/IV secretion system protein AAA_25 PF13481.6 VDK87681.1 - 7.3e-09 35.5 1.0 0.75 9.3 0.0 6.0 6 0 0 6 6 6 1 AAA domain DUF815 PF05673.13 VDK87681.1 - 1.3e-08 34.4 1.1 0.17 11.1 0.0 5.5 6 0 0 6 6 5 2 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 VDK87681.1 - 1.7e-07 31.3 9.8 0.23 11.4 0.0 6.8 8 0 0 8 8 6 1 RsgA GTPase PduV-EutP PF10662.9 VDK87681.1 - 2e-07 30.8 6.5 0.035 13.8 0.0 6.0 7 0 0 7 7 5 1 Ethanolamine utilisation - propanediol utilisation ATPase PF06745.13 VDK87681.1 - 4.6e-07 29.4 0.1 2.2 7.5 0.0 5.5 6 0 0 6 6 5 2 KaiC AAA_11 PF13086.6 VDK87681.1 - 5.3e-07 29.7 0.0 0.08 12.7 0.0 4.1 4 0 0 4 4 3 2 AAA domain IstB_IS21 PF01695.17 VDK87681.1 - 7.1e-07 29.1 0.4 1.3 8.7 0.0 5.3 6 0 0 6 6 5 1 IstB-like ATP binding protein ATPase_2 PF01637.18 VDK87681.1 - 8.6e-07 29.1 6.3 0.14 12.0 0.0 6.6 7 0 0 7 7 6 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 VDK87681.1 - 1.2e-06 28.9 5.3 4.2 7.7 0.0 6.9 7 0 0 7 7 5 0 AAA domain NB-ARC PF00931.22 VDK87681.1 - 2.1e-06 27.1 0.2 1.1 8.3 0.0 4.9 5 0 0 5 5 4 1 NB-ARC domain TniB PF05621.11 VDK87681.1 - 2.8e-06 26.9 0.5 0.14 11.6 0.0 4.8 5 0 0 5 5 5 1 Bacterial TniB protein AAA_24 PF13479.6 VDK87681.1 - 4.7e-06 26.5 0.5 0.17 11.6 0.0 5.2 6 0 0 6 6 5 1 AAA domain AAA_28 PF13521.6 VDK87681.1 - 5.6e-06 26.7 13.1 3.2 8.0 0.0 6.5 7 0 0 7 7 6 0 AAA domain TIP49 PF06068.13 VDK87681.1 - 1.2e-05 24.6 1.3 12 5.0 0.0 5.5 6 0 0 6 6 6 0 TIP49 P-loop domain MMR_HSR1 PF01926.23 VDK87681.1 - 1.3e-05 25.2 0.8 11 6.1 0.0 6.0 6 0 0 6 6 6 0 50S ribosome-binding GTPase ResIII PF04851.15 VDK87681.1 - 1.4e-05 25.1 1.6 3.4 7.6 0.0 5.3 7 0 0 7 7 5 0 Type III restriction enzyme, res subunit AAA_15 PF13175.6 VDK87681.1 - 4e-05 23.5 2.7 0.85 9.3 0.1 4.6 6 0 0 6 6 4 1 AAA ATPase domain SRP54 PF00448.22 VDK87681.1 - 4.2e-05 23.3 7.0 0.41 10.3 0.0 5.1 6 0 0 6 6 5 1 SRP54-type protein, GTPase domain dNK PF01712.19 VDK87681.1 - 5.7e-05 23.1 4.9 14 5.5 0.1 6.4 6 0 0 6 6 6 0 Deoxynucleoside kinase PhoH PF02562.16 VDK87681.1 - 7.4e-05 22.3 0.0 2.1 7.7 0.0 4.9 5 0 0 5 5 5 1 PhoH-like protein AAA_8 PF12780.7 VDK87681.1 - 0.0001 21.7 0.2 18 4.5 0.1 5.4 5 0 0 5 5 5 0 P-loop containing dynein motor region D4 SRPRB PF09439.10 VDK87681.1 - 0.00015 21.3 3.3 9.4 5.6 0.0 5.2 6 0 0 6 6 5 0 Signal recognition particle receptor beta subunit DUF87 PF01935.17 VDK87681.1 - 0.00021 21.4 2.3 3.7 7.6 0.3 4.0 4 0 0 4 4 3 0 Helicase HerA, central domain AAA_2 PF07724.14 VDK87681.1 - 0.00022 21.4 0.0 37 4.4 0.0 5.9 5 1 0 5 5 4 0 AAA domain (Cdc48 subfamily) Roc PF08477.13 VDK87681.1 - 0.00027 21.1 5.3 2.7 8.3 0.1 5.1 5 0 0 5 5 5 0 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 VDK87681.1 - 0.00033 20.4 0.6 0.38 10.4 0.0 4.3 5 0 0 5 5 4 1 ATP synthase alpha/beta family, nucleotide-binding domain IPT PF01745.16 VDK87681.1 - 0.00077 18.9 0.6 7.3 5.9 0.0 4.7 5 0 0 5 5 5 0 Isopentenyl transferase DEAD PF00270.29 VDK87681.1 - 0.00079 19.2 0.0 3.2 7.5 0.0 4.3 4 0 0 4 4 4 0 DEAD/DEAH box helicase AAA_21 PF13304.6 VDK87681.1 - 0.0023 17.8 0.2 5 6.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 VDK87681.1 - 0.0065 15.7 1.2 2.9 6.9 0.1 3.7 4 0 0 4 4 3 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 VDK87681.1 - 0.0086 15.4 0.2 7.3 5.9 0.0 3.5 4 0 0 4 4 3 0 FtsK/SpoIIIE family Septin PF00735.18 VDK87681.1 - 0.021 14.1 3.0 4 6.6 0.0 4.1 5 0 0 5 5 4 0 Septin KAP_NTPase PF07693.14 VDK87681.1 - 0.031 13.5 0.0 44 3.1 0.0 4.2 5 0 0 5 5 4 0 KAP family P-loop domain AIG1 PF04548.16 VDK87681.1 - 0.031 13.6 1.1 5.8 6.2 0.1 3.9 4 0 0 4 4 4 0 AIG1 family PRK PF00485.18 VDK87681.1 - 0.043 13.6 0.6 32 4.2 0.0 4.5 6 0 0 6 6 4 0 Phosphoribulokinase / Uridine kinase family Bac_DnaA PF00308.18 VDK87681.1 - 0.044 13.6 0.0 13 5.6 0.0 3.3 4 0 0 4 4 2 0 Bacterial dnaA protein CPT PF07931.12 VDK87681.1 - 0.11 12.4 6.1 20 4.9 0.1 6.1 7 2 0 7 7 3 0 Chloramphenicol phosphotransferase-like protein DBI_PRT PF02277.17 VDK87681.1 - 0.14 11.4 0.0 18 4.4 0.0 3.2 2 1 1 3 3 3 0 Phosphoribosyltransferase NTPase_1 PF03266.15 VDK87681.1 - 0.36 10.7 11.7 40 4.1 0.1 6.0 6 0 0 6 6 6 0 NTPase Hpr_kinase_C PF07475.12 VDK87681.1 - 0.61 9.6 4.4 69 2.9 0.0 4.7 5 0 0 5 5 5 0 HPr Serine kinase C-terminal domain Ras PF00071.22 VDK87681.1 - 0.68 9.5 4.4 50 3.5 0.0 4.4 4 0 0 4 4 4 0 Ras family ATP_bind_1 PF03029.17 VDK87681.1 - 0.94 9.2 5.4 39 3.9 0.0 4.6 5 0 0 5 5 5 0 Conserved hypothetical ATP binding protein tRNA_lig_kinase PF08303.11 VDK87681.1 - 1.5 8.9 8.9 37 4.3 0.0 5.3 6 0 0 6 6 4 0 tRNA ligase kinase domain AAA_17 PF13207.6 VDK87681.1 - 4.7 7.6 6.7 1.1e+02 3.3 0.1 4.6 5 0 0 5 5 4 0 AAA domain Exo_endo_phos PF03372.23 VDK87683.1 - 2.3e-08 33.8 0.2 6.8e-08 32.3 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 VDK87683.1 - 0.0039 17.0 0.4 0.012 15.5 0.1 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase EF-hand_7 PF13499.6 VDK87684.1 - 8.2e-11 42.2 1.6 1.4e-10 41.4 1.6 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK87684.1 - 1.5e-10 40.1 3.5 4.6e-06 26.1 0.3 2.9 1 1 2 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 VDK87684.1 - 2.4e-10 39.2 0.2 0.001 18.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 VDK87684.1 - 3.3e-09 35.8 0.1 0.0031 16.9 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 VDK87684.1 - 6.8e-06 25.8 0.5 0.0037 17.1 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain pair Dockerin_1 PF00404.18 VDK87684.1 - 0.011 15.9 0.7 0.32 11.2 0.0 2.6 1 1 1 2 2 2 0 Dockerin type I domain SPARC_Ca_bdg PF10591.9 VDK87684.1 - 0.045 14.1 0.2 2 8.7 0.2 2.2 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region MutS_V PF00488.21 VDK87685.1 - 2.6e-40 138.5 0.2 5.4e-40 137.4 0.0 1.6 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 VDK87685.1 - 1.1e-19 71.4 1.7 3.2e-19 69.9 1.7 1.9 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 VDK87685.1 - 9.6e-06 25.9 0.0 2.3e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV DUF4106 PF13388.6 VDK87685.1 - 0.032 13.5 0.0 0.066 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Arm PF00514.23 VDK87686.1 - 7e-25 86.2 18.4 1.1e-05 25.2 0.0 8.7 9 0 0 9 9 9 6 Armadillo/beta-catenin-like repeat IBB PF01749.20 VDK87686.1 - 1e-13 51.5 2.2 2.1e-13 50.5 2.2 1.6 1 0 0 1 1 1 1 Importin beta binding domain HEAT_2 PF13646.6 VDK87686.1 - 1.2e-09 38.5 0.0 0.074 13.5 0.0 3.9 2 2 1 3 3 3 3 HEAT repeats HEAT_EZ PF13513.6 VDK87686.1 - 1.8e-09 37.9 0.2 0.099 13.2 0.0 4.6 3 1 2 5 5 5 2 HEAT-like repeat Arm_3 PF16186.5 VDK87686.1 - 1.2e-08 34.4 0.3 2.3e-08 33.5 0.3 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT PF02985.22 VDK87686.1 - 1.6e-06 27.9 4.3 2.3 8.7 0.0 6.2 6 0 0 6 6 6 1 HEAT repeat Arm_2 PF04826.13 VDK87686.1 - 5.2e-05 22.8 0.2 0.017 14.6 0.1 2.3 2 0 0 2 2 2 2 Armadillo-like RICTOR_V PF14668.6 VDK87686.1 - 0.0011 19.2 5.6 2 8.7 0.3 4.4 4 1 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 DNA_pol_phi PF04931.13 VDK87686.1 - 0.0013 17.0 0.0 0.0023 16.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase phi DUF3361 PF11841.8 VDK87686.1 - 0.0057 16.6 0.1 16 5.4 0.0 3.4 2 1 1 3 3 3 1 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 VDK87686.1 - 0.0072 16.4 0.0 0.69 10.0 0.0 3.5 3 1 1 4 4 4 1 V-ATPase subunit H DUF1410 PF07198.11 VDK87689.1 - 0.012 16.1 0.0 0.032 14.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1410) DUF4030 PF13222.6 VDK87689.1 - 0.043 14.0 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4030) G_glu_transpept PF01019.21 VDK87690.1 - 7.8e-154 513.2 0.0 8.9e-154 513.0 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase FH2 PF02181.23 VDK87691.1 - 1.2e-87 294.5 9.6 1.2e-87 294.5 9.6 1.6 1 1 1 2 2 2 1 Formin Homology 2 Domain DUF3322 PF11795.8 VDK87691.1 - 0.032 14.2 1.2 0.42 10.6 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) XkdW PF09636.10 VDK87691.1 - 0.083 13.0 0.1 0.39 10.8 0.1 2.2 1 0 0 1 1 1 0 XkdW protein DivIC PF04977.15 VDK87691.1 - 3.9 7.3 5.7 2.6 7.9 1.1 3.0 2 0 0 2 2 2 0 Septum formation initiator DUF641 PF04859.12 VDK87691.1 - 4 7.8 8.0 7.3 6.9 0.2 3.5 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) MTHFR PF02219.17 VDK87697.1 - 6.8e-90 301.3 0.0 5.1e-89 298.4 0.0 1.9 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase NNMT_PNMT_TEMT PF01234.17 VDK87702.1 - 9.5e-58 195.4 0.0 1.2e-57 195.0 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 VDK87702.1 - 0.00014 21.8 0.0 0.0014 18.5 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK87702.1 - 0.0023 18.5 0.0 0.014 16.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK87702.1 - 0.015 16.0 0.0 0.069 13.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 VDK87702.1 - 0.033 14.9 0.0 0.088 13.6 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Pox_MCEL PF03291.16 VDK87702.1 - 0.1 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 mRNA capping enzyme Ribosomal_L1 PF00687.21 VDK87704.1 - 1.2e-45 155.7 3.0 1.5e-45 155.4 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family MCM_N PF14551.6 VDK87705.1 - 0.097 13.3 0.1 7.5 7.2 0.0 2.8 2 0 0 2 2 2 0 MCM N-terminal domain DUF3637 PF12337.8 VDK87705.1 - 0.13 12.6 0.1 0.66 10.3 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3637) 60KD_IMP PF02096.20 VDK87709.1 - 1.7e-08 34.6 1.0 1e-07 32.0 1.0 2.0 1 1 0 1 1 1 1 60Kd inner membrane protein DUF2418 PF10332.9 VDK87709.1 - 0.06 13.9 0.6 0.81 10.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2418) PhoD_N PF16655.5 VDK87709.1 - 0.47 11.0 1.8 1.8 9.2 0.2 2.2 2 0 0 2 2 2 0 PhoD-like phosphatase, N-terminal domain 60KD_IMP PF02096.20 VDK87710.1 - 2.7e-19 69.7 22.2 6e-17 62.0 3.4 2.9 3 0 0 3 3 3 2 60Kd inner membrane protein EMC3_TMCO1 PF01956.16 VDK87710.1 - 0.023 14.4 2.6 0.026 14.3 0.2 2.3 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like MCM_bind PF09739.9 VDK87712.1 - 3.2e-32 111.7 3.1 1.8e-28 99.3 2.1 2.6 2 1 0 2 2 2 2 Mini-chromosome maintenance replisome factor DUF89 PF01937.19 VDK87713.1 - 2.1e-96 323.0 0.1 2.4e-96 322.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Pkinase PF00069.25 VDK87714.1 - 5.2e-16 58.8 0.0 6.1e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87714.1 - 1.1e-06 28.2 0.0 1.3e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK87714.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Adap_comp_sub PF00928.21 VDK87719.1 - 1.1e-56 192.1 0.0 2e-56 191.3 0.0 1.4 1 0 0 1 1 1 1 Adaptor complexes medium subunit family PH PF00169.29 VDK87719.1 - 0.013 16.0 0.1 0.048 14.2 0.1 2.0 1 0 0 1 1 1 0 PH domain PH_9 PF15410.6 VDK87719.1 - 0.018 15.4 0.0 0.063 13.7 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain HERV-K_REC PF15695.5 VDK87719.1 - 0.049 13.7 0.4 0.14 12.2 0.4 1.7 1 0 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 MCM_N PF14551.6 VDK87722.1 - 0.097 13.3 0.1 7.5 7.2 0.0 2.8 2 0 0 2 2 2 0 MCM N-terminal domain DUF3637 PF12337.8 VDK87722.1 - 0.13 12.6 0.1 0.66 10.3 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3637) Ribosomal_L1 PF00687.21 VDK87723.1 - 1.2e-45 155.7 3.0 1.5e-45 155.4 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family NNMT_PNMT_TEMT PF01234.17 VDK87725.1 - 9.5e-58 195.4 0.0 1.2e-57 195.0 0.0 1.0 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 VDK87725.1 - 0.00014 21.8 0.0 0.0014 18.5 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK87725.1 - 0.0023 18.5 0.0 0.014 16.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK87725.1 - 0.015 16.0 0.0 0.069 13.9 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 VDK87725.1 - 0.033 14.9 0.0 0.088 13.6 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Pox_MCEL PF03291.16 VDK87725.1 - 0.1 11.7 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 mRNA capping enzyme LRR_8 PF13855.6 VDK87729.1 - 4.6e-13 48.7 9.8 8.6e-10 38.2 2.7 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 VDK87729.1 - 5.2e-12 45.8 6.6 2.6e-06 27.7 0.5 2.5 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDK87729.1 - 0.001 19.3 9.6 1.6 9.6 0.1 4.4 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_6 PF13516.6 VDK87729.1 - 0.0014 18.5 3.1 2.4 8.4 0.0 3.5 3 0 0 3 3 3 2 Leucine Rich repeat Sec23_trunk PF04811.15 VDK87730.1 - 5.4e-55 186.6 0.0 9.6e-55 185.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 VDK87730.1 - 3.8e-19 68.4 0.2 1.2e-18 66.8 0.1 1.9 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 VDK87730.1 - 1.2e-18 67.6 0.0 2.4e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 VDK87730.1 - 4.5e-12 45.8 5.5 1.1e-11 44.6 5.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 VDK87730.1 - 3.4e-07 30.1 0.0 7.2e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 VDK87730.1 - 0.039 13.4 0.1 0.11 11.9 0.1 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Band_7 PF01145.25 VDK87731.1 - 5e-21 75.5 0.1 5e-21 75.5 0.1 2.1 1 1 1 2 2 2 1 SPFH domain / Band 7 family OpuAC PF04069.12 VDK87731.1 - 0.0069 16.0 0.4 0.0098 15.5 0.4 1.3 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system RhoGEF PF00621.20 VDK87734.1 - 1.5e-30 106.7 2.2 2.4e-30 106.1 2.2 1.3 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 VDK87734.1 - 4.6e-21 75.3 0.1 9.1e-21 74.3 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain SH3_1 PF00018.28 VDK87736.1 - 5e-64 211.7 14.2 6.1e-16 57.8 0.3 6.3 6 0 0 6 6 6 5 SH3 domain SH3_9 PF14604.6 VDK87736.1 - 2.9e-61 203.1 5.1 2.1e-12 46.7 0.0 6.4 6 0 0 6 6 6 6 Variant SH3 domain SH3_2 PF07653.17 VDK87736.1 - 2.9e-47 158.1 0.1 1.8e-11 43.5 0.0 5.6 5 1 0 5 5 5 5 Variant SH3 domain EF-hand_4 PF12763.7 VDK87736.1 - 1.7e-27 95.4 0.0 3e-12 46.4 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 VDK87736.1 - 1.4e-06 27.4 0.0 0.0021 17.5 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 VDK87736.1 - 1.5e-05 25.3 0.0 0.0044 17.4 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK87736.1 - 6.9e-05 22.5 0.0 0.41 10.7 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain DUF3104 PF11302.8 VDK87736.1 - 0.00045 19.9 2.7 0.38 10.5 0.2 3.5 4 0 0 4 4 4 2 Protein of unknown function (DUF3104) EF-hand_5 PF13202.6 VDK87736.1 - 0.0067 15.9 0.1 0.11 12.0 0.0 2.7 3 0 0 3 3 3 1 EF hand DUF555 PF04475.12 VDK87736.1 - 0.0089 16.3 0.1 0.022 15.1 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF555) EF-hand_8 PF13833.6 VDK87736.1 - 0.082 12.8 0.2 0.25 11.2 0.0 1.9 2 0 0 2 2 1 0 EF-hand domain pair SH3_10 PF17902.1 VDK87736.1 - 0.19 11.9 0.6 2.3 8.3 0.0 2.9 3 0 0 3 3 3 0 SH3 domain Mistic PF11458.8 VDK87739.1 - 0.078 13.0 0.1 0.42 10.6 0.1 2.1 2 0 0 2 2 2 0 Membrane-integrating protein Mistic zf-C2HE PF16278.5 VDK87739.1 - 1.5 9.4 8.6 11 6.5 0.9 3.5 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_4 PF13894.6 VDK87739.1 - 1.8 9.6 15.8 5.9 8.0 0.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger Glutaredoxin PF00462.24 VDK87741.1 - 1.6e-17 63.4 0.2 2.5e-17 62.8 0.2 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 VDK87741.1 - 0.0025 18.2 0.1 0.0044 17.4 0.1 1.5 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 VDK87741.1 - 0.015 15.3 0.1 0.033 14.2 0.1 1.6 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_2 PF13098.6 VDK87741.1 - 0.019 15.4 0.3 0.036 14.5 0.3 1.5 1 1 0 1 1 1 0 Thioredoxin-like domain DSBA PF01323.20 VDK87741.1 - 0.11 12.2 1.1 0.38 10.5 0.2 2.0 1 1 0 2 2 2 0 DSBA-like thioredoxin domain MMR_HSR1 PF01926.23 VDK87744.1 - 2.6e-14 53.3 0.0 1.5e-13 50.8 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK87744.1 - 2.4e-08 33.6 0.2 6.5e-07 29.0 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 VDK87744.1 - 5e-07 29.5 0.0 0.0016 18.0 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK87744.1 - 1.3e-06 28.4 0.2 5.7e-05 23.1 0.2 2.2 1 1 0 1 1 1 1 RsgA GTPase AIG1 PF04548.16 VDK87744.1 - 1.5e-06 27.7 0.0 2.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 AIG1 family Septin PF00735.18 VDK87744.1 - 0.00018 20.9 0.0 0.00032 20.1 0.0 1.3 1 0 0 1 1 1 1 Septin Dynamin_N PF00350.23 VDK87744.1 - 0.0051 16.9 0.7 1.7 8.7 0.3 2.4 1 1 1 2 2 2 2 Dynamin family ATP_bind_1 PF03029.17 VDK87744.1 - 0.026 14.3 0.0 0.5 10.1 0.0 2.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 VDK87744.1 - 0.037 14.6 0.0 0.091 13.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain IIGP PF05049.13 VDK87744.1 - 0.091 11.8 0.0 0.16 11.0 0.0 1.4 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) G-alpha PF00503.20 VDK87744.1 - 0.12 11.5 0.1 14 4.7 0.0 2.2 1 1 1 2 2 2 0 G-protein alpha subunit Roc PF08477.13 VDK87744.1 - 0.12 12.5 0.0 0.53 10.5 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase wnt PF00110.19 VDK87751.1 - 1.2e-93 314.1 26.6 1.3e-93 314.0 26.6 1.0 1 0 0 1 1 1 1 wnt family Pkinase PF00069.25 VDK87752.1 - 2.7e-32 112.2 0.2 4.2e-32 111.5 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87752.1 - 9.8e-30 103.7 1.9 9.7e-29 100.4 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Activin_recp PF01064.23 VDK87752.1 - 1.1e-10 42.5 7.0 3.8e-10 40.7 7.0 2.0 1 0 0 1 1 1 1 Activin types I and II receptor domain Pkinase_fungal PF17667.1 VDK87752.1 - 3.4e-05 22.8 0.0 4.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase TGF_beta_GS PF08515.12 VDK87752.1 - 0.00032 20.1 0.3 0.00092 18.7 0.3 1.8 1 0 0 1 1 1 1 Transforming growth factor beta type I GS-motif FTA2 PF13095.6 VDK87752.1 - 0.0087 15.7 0.0 0.027 14.1 0.0 1.7 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 VDK87752.1 - 0.0097 15.8 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family GAPT PF11770.8 VDK87752.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Pou PF00157.17 VDK87758.1 - 2.3e-34 117.2 0.1 4.7e-34 116.2 0.1 1.5 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 VDK87758.1 - 1.6e-16 59.9 0.1 3.4e-16 58.8 0.1 1.6 1 0 0 1 1 1 1 Homeodomain UCH_1 PF13423.6 VDK87758.1 - 0.026 14.1 0.5 0.045 13.3 0.5 1.4 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Guanylin PF02058.15 VDK87759.1 - 0.28 11.7 1.1 0.8 10.2 0.0 2.4 2 0 0 2 2 2 0 Guanylin precursor TORC_N PF12884.7 VDK87760.1 - 3.8e-19 69.2 0.0 3.8e-19 69.2 0.0 2.9 2 1 0 2 2 2 1 Transducer of regulated CREB activity, N terminus Fumble PF03630.14 VDK87762.1 - 1.5e-109 366.2 0.0 1.8e-109 365.9 0.0 1.1 1 0 0 1 1 1 1 Fumble Acyltransferase PF01553.21 VDK87763.1 - 3.7e-19 68.7 0.1 1.2e-18 67.1 0.0 1.9 3 0 0 3 3 3 1 Acyltransferase RBD PF02196.15 VDK87763.1 - 2.6e-18 65.8 0.0 6.1e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Raf-like Ras-binding domain C1_1 PF00130.22 VDK87763.1 - 4.8e-11 42.4 8.8 4.8e-11 42.4 8.8 2.0 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 VDK87763.1 - 0.00072 19.8 3.9 0.00072 19.8 3.9 2.3 3 0 0 3 3 3 1 C1 domain zf-RING-like PF08746.11 VDK87763.1 - 0.062 13.6 4.8 0.17 12.2 4.8 1.8 1 0 0 1 1 1 0 RING-like domain Y_phosphatase PF00102.27 VDK87765.1 - 4.5e-07 29.7 0.0 5.5e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 VDK87765.1 - 0.00042 20.1 0.0 0.00049 19.9 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK87765.1 - 0.12 12.3 0.2 1 9.2 0.0 1.9 1 1 1 2 2 2 0 Tyrosine phosphatase family THOC7 PF05615.13 VDK87766.1 - 8.4e-25 87.6 2.0 8.4e-25 87.6 2.0 1.5 2 0 0 2 2 2 1 Tho complex subunit 7 PG_binding_3 PF09374.10 VDK87766.1 - 0.068 13.4 0.7 0.14 12.4 0.6 1.7 1 1 0 1 1 1 0 Predicted Peptidoglycan domain Ca_bind_SSO6904 PF18249.1 VDK87766.1 - 0.14 12.5 4.2 2.2 8.7 0.6 2.7 1 1 1 2 2 2 0 Calcium binding protein SSO6904 DUF1664 PF07889.12 VDK87766.1 - 0.22 11.5 5.1 0.24 11.5 3.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 VDK87766.1 - 3 8.3 11.4 0.96 9.9 1.4 2.1 1 1 1 2 2 2 0 Snapin/Pallidin Ada3 PF10198.9 VDK87766.1 - 4.9 7.3 10.6 3.2 7.9 2.1 2.0 1 1 1 2 2 2 0 Histone acetyltransferases subunit 3 Rootletin PF15035.6 VDK87767.1 - 0.002 18.2 14.3 0.002 18.2 14.3 2.8 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion VirD1 PF07328.11 VDK87767.1 - 0.0046 16.9 0.1 0.011 15.7 0.1 1.6 1 0 0 1 1 1 1 T-DNA border endonuclease VirD1 HLH PF00010.26 VDK87769.1 - 2.8e-16 59.2 2.4 6.1e-16 58.1 2.4 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF3231 PF11553.8 VDK87769.1 - 0.05 13.2 0.2 0.65 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) PDZ PF00595.24 VDK87770.1 - 4.5e-12 46.1 0.0 8.3e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDK87770.1 - 2.1e-09 37.1 0.0 5.3e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK87770.1 - 0.0004 20.6 0.0 0.0011 19.3 0.0 1.7 1 0 0 1 1 1 1 PDZ domain Pex24p PF06398.11 VDK87777.1 - 0.055 12.4 4.0 0.055 12.5 4.0 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF805 PF05656.14 VDK87777.1 - 0.39 11.1 7.1 0.43 11.0 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF805) DUF4870 PF09685.10 VDK87777.1 - 0.43 10.7 16.3 0.55 10.4 16.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) Halogen_Hydrol PF10112.9 VDK87777.1 - 0.43 10.6 6.4 0.48 10.4 6.4 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF3093 PF11292.8 VDK87777.1 - 1.2 9.4 9.5 1.3 9.3 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) DUF4191 PF13829.6 VDK87777.1 - 1.9 7.8 14.4 2.2 7.6 14.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF2975 PF11188.8 VDK87777.1 - 2.5 8.0 14.7 2.7 7.9 14.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) DUF2070 PF09843.9 VDK87777.1 - 2.6 6.2 11.5 2.8 6.1 11.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF3043 PF11241.8 VDK87777.1 - 2.8 8.0 12.0 3.3 7.7 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF2207 PF09972.9 VDK87777.1 - 4 6.1 11.0 4.4 5.9 11.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PHO4 PF01384.20 VDK87777.1 - 4.8 6.1 8.8 4.7 6.2 8.8 1.0 1 0 0 1 1 1 0 Phosphate transporter family SMC_N PF02463.19 VDK87782.1 - 4.3e-26 91.7 13.7 1.1e-25 90.4 13.7 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 VDK87782.1 - 1e-19 70.9 0.8 4e-18 65.8 0.0 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 VDK87782.1 - 0.0064 16.3 2.0 0.04 13.7 0.0 3.1 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SNARE PF05739.19 VDK87782.1 - 0.044 13.8 0.4 0.27 11.2 0.4 2.5 1 0 0 1 1 1 0 SNARE domain DUF1488 PF07369.11 VDK87782.1 - 0.096 12.7 0.7 2.7 8.0 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1488) ANAPC5 PF12862.7 VDK87782.1 - 1.1 9.4 5.0 10 6.3 0.5 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 Fez1 PF06818.15 VDK87782.1 - 5.5 7.4 85.7 0.14 12.6 14.0 5.5 2 2 3 5 5 5 0 Fez1 DB PF01682.19 VDK87784.1 - 9.1e-19 67.6 14.3 1.3e-18 67.2 14.3 1.2 1 0 0 1 1 1 1 DB module BING4CT PF08149.11 VDK87793.1 - 1.1e-34 118.0 0.0 3.4e-34 116.5 0.0 1.9 2 0 0 2 2 2 1 BING4CT (NUC141) domain SNARE_assoc PF09335.11 VDK87793.1 - 5.9e-18 65.5 9.7 1.2e-17 64.5 7.7 2.3 2 0 0 2 2 2 1 SNARE associated Golgi protein ANAPC4_WD40 PF12894.7 VDK87793.1 - 0.00016 21.9 0.0 1.8 8.9 0.0 4.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDK87793.1 - 0.0022 18.8 0.0 0.7 10.9 0.0 4.0 5 0 0 5 5 5 1 WD domain, G-beta repeat WD40_like PF17005.5 VDK87793.1 - 0.0031 16.9 0.0 0.0057 16.0 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 VDK87793.1 - 0.0094 14.6 0.0 0.019 13.6 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 VDK87793.1 - 0.017 14.2 0.0 0.033 13.2 0.0 1.4 1 0 0 1 1 1 0 Coatomer WD associated region RRM_1 PF00076.22 VDK87794.1 - 0.0036 17.1 0.3 0.044 13.6 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_1 PF00036.32 VDK87795.1 - 1.1e-18 65.2 1.5 1.4e-08 33.7 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 VDK87795.1 - 2.9e-15 55.8 5.9 8.4e-14 51.2 1.8 1.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 VDK87795.1 - 3.2e-15 56.3 1.1 4.3e-15 55.9 1.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 VDK87795.1 - 1.2e-11 43.5 0.6 2.2e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 VDK87795.1 - 1.1e-08 34.2 0.9 6.9e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 EF hand p25-alpha PF05517.12 VDK87795.1 - 0.0013 18.9 1.5 0.0072 16.5 0.2 2.0 1 1 1 2 2 2 2 p25-alpha DUF3349 PF11829.8 VDK87795.1 - 0.0015 19.3 0.0 0.0018 19.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3349) TerB PF05099.13 VDK87795.1 - 0.01 15.8 0.1 0.012 15.5 0.1 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TerB Caleosin PF05042.13 VDK87795.1 - 0.024 14.6 1.1 2.1 8.2 0.1 2.0 1 1 1 2 2 2 0 Caleosin related protein Arylsulfotrans PF05935.11 VDK87795.1 - 0.05 12.5 0.8 0.047 12.6 0.8 1.0 1 0 0 1 1 1 0 Arylsulfotransferase (ASST) UPF0154 PF03672.13 VDK87795.1 - 0.052 13.6 0.0 0.07 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) RTX_C PF08339.10 VDK87795.1 - 0.072 13.2 0.0 0.082 13.0 0.0 1.1 1 0 0 1 1 1 0 RTX C-terminal domain PXA PF02194.15 VDK87798.1 - 0.24 11.4 2.1 19 5.2 0.0 3.0 3 1 0 3 3 3 0 PXA domain P120R PF08062.11 VDK87798.1 - 4.4 7.8 6.0 27 5.3 0.2 2.6 2 0 0 2 2 2 0 P120R (NUC006) repeat GGACT PF06094.12 VDK87799.1 - 7.9e-25 87.8 0.0 9.8e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 VDK87799.1 - 1.9e-07 31.4 0.1 4e-07 30.3 0.1 1.5 2 0 0 2 2 2 1 AIG2-like family zf-C2HCIx2C PF10782.9 VDK87799.1 - 0.05 13.5 0.1 0.086 12.8 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger Ribosomal_S10 PF00338.22 VDK87800.1 - 4.8e-17 62.0 0.5 7.7e-17 61.3 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF4724 PF15852.5 VDK87800.1 - 0.093 13.2 0.4 0.21 12.1 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4724) Ribosomal_L36 PF00444.18 VDK87803.1 - 5e-10 39.4 1.6 8.4e-10 38.7 1.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 Cyd_oper_YbgE PF09600.10 VDK87803.1 - 0.099 13.0 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Cyd operon protein YbgE (Cyd_oper_YbgE) RNA_pol_Rpc82 PF05645.13 VDK87805.1 - 2.1e-18 67.0 0.4 2.9e-17 63.3 0.0 2.5 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 VDK87805.1 - 3.5e-18 65.4 0.1 3.8e-07 30.1 0.0 3.6 3 0 0 3 3 3 3 RNA polymerase III subunit RPC82 helix-turn-helix domain T4_baseplate PF12322.8 VDK87805.1 - 0.079 12.4 0.3 0.15 11.5 0.3 1.4 1 0 0 1 1 1 0 T4 bacteriophage base plate protein GntR PF00392.21 VDK87805.1 - 0.13 11.9 0.0 0.85 9.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Penicillinase_R PF03965.16 VDK87805.1 - 0.14 12.5 0.0 6.6 7.1 0.0 2.8 2 1 1 3 3 3 0 Penicillinase repressor RRM_1 PF00076.22 VDK87811.1 - 3.1e-11 42.9 0.0 2e-06 27.5 0.0 3.2 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 VDK87811.1 - 0.025 14.6 0.1 0.18 11.8 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif PHM7_cyt PF14703.6 VDK87811.1 - 0.049 13.9 0.0 3 8.1 0.0 2.8 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter RRM_1 PF00076.22 VDK87812.1 - 2.1e-10 40.3 0.0 4.3e-06 26.5 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 VDK87812.1 - 0.03 14.5 0.0 0.064 13.5 0.0 1.5 1 0 0 1 1 1 0 RRM-like domain PHM7_cyt PF14703.6 VDK87812.1 - 0.06 13.6 0.4 2.1 8.6 0.1 2.4 2 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Pkinase PF00069.25 VDK87817.1 - 3.6e-58 197.0 0.0 5.8e-58 196.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87817.1 - 1.3e-29 103.3 0.0 2e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDK87817.1 - 0.0045 16.9 0.1 0.015 15.2 0.1 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 VDK87817.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Phage_holin_3_6 PF07332.11 VDK87818.1 - 0.11 12.5 0.6 0.2 11.7 0.6 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III CHCH PF06747.13 VDK87819.1 - 8.4e-07 29.0 1.4 1.7e-06 28.0 1.4 1.6 1 0 0 1 1 1 1 CHCH domain UCR_hinge PF02320.16 VDK87819.1 - 0.037 14.2 1.2 1.1 9.5 0.1 2.3 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein GIT1_C PF12205.8 VDK87819.1 - 0.053 13.6 0.0 6.9 6.8 0.0 2.1 1 1 1 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term Cmc1 PF08583.10 VDK87819.1 - 0.13 12.3 2.1 4.7 7.3 0.3 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like RF-1 PF00472.20 VDK87820.1 - 1.7e-29 102.1 2.7 2.5e-29 101.6 2.7 1.2 1 0 0 1 1 1 1 RF-1 domain PCRF PF03462.18 VDK87820.1 - 5.7e-15 55.7 1.4 1.5e-14 54.3 0.1 2.1 2 1 0 2 2 2 1 PCRF domain PCRF PF03462.18 VDK87821.1 - 5.7e-06 26.3 1.5 7.1e-06 26.0 1.5 1.1 1 0 0 1 1 1 1 PCRF domain Glyco_H_20C_C PF18088.1 VDK87821.1 - 0.015 15.2 0.9 0.017 15.0 0.9 1.1 1 0 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain DUF4110 PF13422.6 VDK87821.1 - 0.026 14.6 0.2 0.041 14.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) AceK PF06315.11 VDK87821.1 - 0.052 12.0 0.2 0.059 11.9 0.2 1.0 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) CPSase_L_D3 PF02787.19 VDK87821.1 - 0.092 13.1 0.4 0.34 11.3 0.3 1.9 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Pkinase PF00069.25 VDK87825.1 - 4.1e-49 167.3 1.4 8.5e-49 166.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87825.1 - 3.7e-39 134.6 0.0 9.6e-39 133.2 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 VDK87825.1 - 9.3e-16 57.8 4.2 9.3e-16 57.8 4.2 3.0 3 0 0 3 3 3 2 Oxidative-stress-responsive kinase 1 C-terminal domain Sec16 PF12932.7 VDK87825.1 - 1.3 9.6 5.7 0.22 12.1 0.5 2.4 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region DUF3807 PF12720.7 VDK87825.1 - 7 6.9 22.6 0.11 12.8 14.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) Pkinase PF00069.25 VDK87827.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain GTP1_OBG PF01018.22 VDK87829.1 - 6.4e-48 162.3 5.0 8.6e-48 161.8 5.0 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 VDK87829.1 - 6.2e-23 81.1 0.0 9.9e-23 80.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK87829.1 - 5.3e-09 35.8 0.0 1.7e-08 34.1 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 VDK87829.1 - 0.0031 16.9 0.0 0.0045 16.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 VDK87829.1 - 0.013 15.4 0.0 0.56 10.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 VDK87829.1 - 0.028 14.0 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 VDK87829.1 - 0.16 12.0 0.0 13 5.8 0.0 2.2 1 1 1 2 2 2 0 Dynamin family Endonuc-BsobI PF09194.10 VDK87830.1 - 0.021 14.0 0.1 0.024 13.8 0.1 1.0 1 0 0 1 1 1 0 Restriction endonuclease BsobI Orthopox_A36R PF05950.11 VDK87830.1 - 0.033 14.4 0.4 0.041 14.0 0.4 1.1 1 0 0 1 1 1 0 Orthopoxvirus A36R protein DUF4714 PF15833.5 VDK87830.1 - 0.13 12.2 0.3 0.15 12.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4714) Hormone_recep PF00104.30 VDK87831.1 - 0.00052 19.7 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor PSK_trans_fac PF07704.11 VDK87831.1 - 0.0033 18.1 0.0 0.0088 16.8 0.0 1.7 1 0 0 1 1 1 1 Rv0623-like transcription factor COE1_DBD PF16422.5 VDK87835.1 - 4.8e-126 418.9 0.4 6.4e-126 418.5 0.4 1.1 1 0 0 1 1 1 1 Transcription factor COE1 DNA-binding domain COE1_HLH PF16423.5 VDK87835.1 - 2.9e-27 94.1 0.5 6e-27 93.1 0.5 1.6 1 0 0 1 1 1 1 Transcription factor COE1 helix-loop-helix domain TIG PF01833.24 VDK87835.1 - 1.1e-10 41.4 0.2 2.9e-10 40.1 0.2 1.8 1 0 0 1 1 1 1 IPT/TIG domain Pkinase PF00069.25 VDK87837.1 - 1.7e-50 171.9 0.0 2e-50 171.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87837.1 - 8.8e-26 90.7 0.0 1.2e-25 90.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK87837.1 - 3.2e-07 30.0 0.0 4.4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK87837.1 - 1.1e-05 24.5 0.0 1.8e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 VDK87837.1 - 0.19 10.8 0.0 0.27 10.2 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 DEAD PF00270.29 VDK87842.1 - 2.7e-05 24.0 0.0 3.6e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Prominin PF05478.11 VDK87844.1 - 9e-50 169.5 16.5 1.1e-49 169.2 16.5 1.0 1 0 0 1 1 1 1 Prominin ApoLp-III PF07464.11 VDK87844.1 - 0.044 13.9 3.5 0.1 12.7 0.2 2.9 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) PP_kinase_N PF13089.6 VDK87844.1 - 0.18 12.1 2.4 1.6 9.1 0.1 2.7 2 0 0 2 2 2 0 Polyphosphate kinase N-terminal domain RBFA PF02033.18 VDK87844.1 - 4.6 7.8 9.6 0.64 10.5 0.2 3.4 4 0 0 4 4 4 0 Ribosome-binding factor A p450 PF00067.22 VDK87849.1 - 4.5e-93 312.5 0.2 5.1e-93 312.3 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 ELFV_dehydrog_N PF02812.18 VDK87849.1 - 0.2 11.5 0.0 0.5 10.3 0.0 1.6 1 1 0 1 1 1 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain RNase_T PF00929.24 VDK87850.1 - 1.6e-27 97.1 0.1 4.2e-27 95.7 0.1 1.7 1 0 0 1 1 1 1 Exonuclease SAP PF02037.27 VDK87850.1 - 1.1e-07 31.4 0.2 2.6e-07 30.3 0.2 1.7 1 0 0 1 1 1 1 SAP domain Tmemb_185A PF10269.9 VDK87851.1 - 1.6e-05 24.8 13.7 0.11 12.1 0.6 2.4 1 1 0 2 2 2 2 Transmembrane Fragile-X-F protein DPM3 PF08285.11 VDK87851.1 - 0.54 10.5 8.8 0.57 10.4 0.6 2.2 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF202 PF02656.15 VDK87851.1 - 5 7.6 7.6 0.63 10.5 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) ETF PF01012.21 VDK87852.1 - 3.9e-44 150.7 0.7 4.9e-44 150.4 0.7 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain TPP_enzyme_M PF00205.22 VDK87852.1 - 0.01 15.6 0.1 0.041 13.6 0.0 1.9 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain SMC_N PF02463.19 VDK87853.1 - 1.7e-38 132.3 3.1 5.3e-38 130.6 3.1 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 VDK87853.1 - 1.1e-14 55.4 11.3 6e-14 53.0 11.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 VDK87853.1 - 2.9e-09 37.1 0.0 6e-09 36.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 VDK87853.1 - 7.2e-06 26.0 0.2 7.2e-06 26.0 0.2 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 VDK87853.1 - 1e-05 25.1 0.0 2.2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNase_H2-Ydr279 PF09468.10 VDK87853.1 - 0.0015 18.7 0.3 0.0024 18.1 0.3 1.2 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain AAA_27 PF13514.6 VDK87853.1 - 0.0035 17.0 0.6 0.044 13.4 0.0 2.3 2 1 0 2 2 2 1 AAA domain DUF2813 PF11398.8 VDK87853.1 - 0.0048 16.2 2.7 0.011 15.1 2.6 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2813) PilN PF05137.13 VDK87853.1 - 0.099 12.8 0.0 0.83 9.8 0.0 2.4 2 0 0 2 2 2 0 Fimbrial assembly protein (PilN) ABC_tran PF00005.27 VDK87853.1 - 0.28 11.7 4.2 0.11 12.9 0.4 2.2 2 2 0 2 2 2 0 ABC transporter DUF87 PF01935.17 VDK87853.1 - 0.37 10.9 4.0 5.5 7.0 1.6 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain DUF1664 PF07889.12 VDK87853.1 - 3.2 7.8 6.0 3.5 7.7 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) zf-C2H2_4 PF13894.6 VDK87856.1 - 2e-07 31.3 28.4 0.1 13.5 2.3 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-CRD PF17979.1 VDK87856.1 - 3.6e-05 23.9 7.5 0.11 12.6 0.0 3.4 3 0 0 3 3 3 2 Cysteine rich domain with multizinc binding regions zf-C2H2 PF00096.26 VDK87856.1 - 0.00016 21.9 29.0 0.21 12.1 2.9 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 VDK87856.1 - 0.00045 20.5 15.3 0.0029 17.9 4.4 3.3 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) Yippee-Mis18 PF03226.14 VDK87856.1 - 4.4 7.6 14.6 0.053 13.7 2.5 3.0 3 1 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C2H2_3rep PF18868.1 VDK87856.1 - 9.2 7.0 12.0 29 5.4 0.1 4.5 3 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 VDK87857.1 - 0.0011 19.2 0.8 0.9 9.9 1.8 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDK87857.1 - 0.0048 17.2 9.1 0.41 11.0 1.2 3.3 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) FtsZ_C PF12327.8 VDK87857.1 - 0.0096 16.2 0.1 0.024 14.9 0.1 1.6 1 0 0 1 1 1 1 FtsZ family, C-terminal domain Radical_SAM PF04055.21 VDK87857.1 - 0.034 14.5 0.1 0.059 13.8 0.1 1.4 1 0 0 1 1 1 0 Radical SAM superfamily zf-Di19 PF05605.12 VDK87857.1 - 0.098 13.0 11.4 0.43 10.9 0.1 4.0 5 0 0 5 5 5 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 VDK87857.1 - 0.35 11.8 22.8 2.9 9.0 0.5 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK87857.1 - 0.71 10.5 18.4 0.35 11.4 2.5 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type Thioredoxin PF00085.20 VDK87860.1 - 4.7e-32 110.0 0.0 9.4e-32 109.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 VDK87860.1 - 4.3e-14 52.8 0.0 1.3e-09 38.3 0.1 2.2 2 0 0 2 2 2 2 Thioredoxin-like domain Calsequestrin PF01216.17 VDK87860.1 - 9.4e-08 31.5 0.1 1.3e-07 31.1 0.1 1.2 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_2 PF13098.6 VDK87860.1 - 6.7e-05 23.3 0.1 0.00036 21.0 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK87860.1 - 0.0042 17.4 0.0 0.21 11.9 0.0 2.5 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 VDK87860.1 - 0.036 13.4 0.0 0.057 12.8 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 VDK87860.1 - 0.045 13.9 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 VDK87860.1 - 0.078 12.9 0.1 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 AhpC/TSA family RUN PF02759.19 VDK87861.1 - 1.2e-22 80.4 1.3 2.1e-22 79.5 0.1 2.0 2 1 0 2 2 2 1 RUN domain PAP_central PF04928.17 VDK87861.1 - 0.81 8.6 10.5 2.2 7.2 1.4 2.2 1 1 1 2 2 2 0 Poly(A) polymerase central domain CNH PF00780.22 VDK87862.1 - 0.0017 18.0 0.3 0.0036 16.9 0.3 1.6 1 0 0 1 1 1 1 CNH domain TPR_2 PF07719.17 VDK87862.1 - 0.023 14.8 0.0 0.089 13.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat YdjO PF14169.6 VDK87862.1 - 0.093 12.5 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Cold-inducible protein YdjO DUF4883 PF16224.5 VDK87862.1 - 0.096 12.9 0.1 0.23 11.7 0.1 1.6 1 0 0 1 1 1 0 DOmain of unknown function (DUF4883) VHS PF00790.19 VDK87863.1 - 3.8e-38 130.5 0.0 7.2e-38 129.6 0.0 1.5 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 VDK87863.1 - 3.1e-17 62.6 2.1 1.1e-16 60.9 2.1 2.0 1 0 0 1 1 1 1 GAT domain ENTH PF01417.20 VDK87863.1 - 0.0047 17.0 0.0 0.0095 16.0 0.0 1.5 1 0 0 1 1 1 1 ENTH domain CorA PF01544.18 VDK87863.1 - 0.1 11.9 1.9 0.21 10.9 0.1 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Filamin PF00630.19 VDK87865.1 - 2e-156 510.3 28.7 2e-14 54.2 0.1 18.9 17 2 0 17 17 17 16 Filamin/ABP280 repeat CH PF00307.31 VDK87865.1 - 8.1e-28 96.8 0.1 2.1e-13 50.4 0.0 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain Y_Y_Y PF07495.13 VDK87865.1 - 8.8e-07 28.8 0.7 3.8 7.5 0.0 8.1 10 0 0 10 10 10 1 Y_Y_Y domain DUF5060 PF16586.5 VDK87865.1 - 0.011 16.1 0.0 4.9 7.6 0.0 5.2 6 0 0 6 6 6 0 Domain of unknown function (DUF5060) Big_3_5 PF16640.5 VDK87865.1 - 0.016 15.4 1.5 11 6.3 0.0 5.6 7 0 0 7 7 7 0 Bacterial Ig-like domain (group 3) PapC_N PF13954.6 VDK87865.1 - 0.17 11.9 0.0 32 4.5 0.0 4.5 5 0 0 5 5 5 0 PapC N-terminal domain ETX_MTX2 PF03318.13 VDK87866.1 - 7.2e-05 22.7 0.1 0.0001 22.2 0.1 1.2 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 ADH_zinc_N PF00107.26 VDK87867.1 - 1.9e-22 79.6 0.0 3.2e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 VDK87867.1 - 3.7e-09 37.7 0.1 7.5e-09 36.7 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 VDK87867.1 - 2.4e-08 33.8 0.1 4.7e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain TGT PF01702.18 VDK87868.1 - 1e-122 409.7 0.0 1.2e-122 409.4 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Peptidase_M14 PF00246.24 VDK87869.1 - 1.1e-72 245.3 0.0 1.4e-72 245.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 VDK87869.1 - 2e-13 50.4 0.1 3.9e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 VDK87869.1 - 4e-05 23.5 0.0 8.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 CarboxypepD_reg-like domain PBC PF03792.13 VDK87873.1 - 5.6e-82 274.1 4.2 9.1e-82 273.4 4.2 1.3 1 0 0 1 1 1 1 PBC domain Homeodomain PF00046.29 VDK87873.1 - 4.6e-19 68.0 2.1 4.6e-19 68.0 2.1 2.3 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 VDK87873.1 - 5.9e-16 58.1 1.3 2.5e-15 56.1 0.0 2.6 3 0 0 3 3 3 1 Homeobox KN domain YdaS_antitoxin PF15943.5 VDK87873.1 - 0.014 15.2 0.1 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Cor1 PF04803.12 VDK87873.1 - 0.028 14.6 1.0 0.028 14.6 1.0 2.8 3 1 0 3 3 3 0 Cor1/Xlr/Xmr conserved region NUC130_3NT PF08158.12 VDK87873.1 - 1.2 9.5 4.6 13 6.2 0.0 3.5 4 0 0 4 4 4 0 NUC130/3NT domain ANAPC4_WD40 PF12894.7 VDK87875.1 - 0.041 14.2 0.0 1.1 9.6 0.0 2.8 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Phospholip_B PF04916.13 VDK87876.1 - 4.5e-114 381.9 1.2 5.9e-114 381.5 1.2 1.0 1 0 0 1 1 1 1 Phospholipase B DUP PF00674.18 VDK87876.1 - 1.7 8.8 5.9 0.57 10.4 0.4 2.6 3 0 0 3 3 3 0 DUP family Med29 PF11568.8 VDK87883.1 - 3.8e-06 27.2 9.8 0.011 16.0 0.6 3.6 2 1 0 3 3 3 2 Mediator complex subunit 29 TPR_2 PF07719.17 VDK87885.1 - 6.2e-10 38.4 0.4 0.0096 16.0 0.0 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 VDK87885.1 - 4.1e-07 29.6 1.4 1 9.5 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK87885.1 - 5.3e-07 29.2 0.0 0.058 13.2 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK87885.1 - 7.7e-07 28.7 2.8 0.44 10.3 0.0 6.0 5 3 2 7 7 7 2 TPR repeat TPR_14 PF13428.6 VDK87885.1 - 9.4e-06 26.0 6.4 4.2 8.4 0.6 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK87885.1 - 0.00062 20.0 1.2 2.6 8.4 0.0 4.3 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK87885.1 - 0.0022 18.1 0.2 2.3 8.7 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 VDK87885.1 - 0.014 14.6 0.7 0.035 13.3 0.2 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ATP-synt_Eps PF04627.13 VDK87885.1 - 0.037 14.0 0.0 0.18 11.8 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase epsilon chain TPR_16 PF13432.6 VDK87885.1 - 0.083 13.6 1.2 17 6.1 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DeoC PF01791.9 VDK87892.1 - 0.054 13.1 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 DeoC/LacD family aldolase Helitron_like_N PF14214.6 VDK87892.1 - 0.12 12.6 0.0 0.14 12.4 0.0 1.1 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus SPOC PF07744.13 VDK87893.1 - 2.2e-29 102.3 3.3 2.2e-29 102.3 0.1 2.8 3 0 0 3 3 3 1 SPOC domain Neur_chan_LBD PF02931.23 VDK87896.1 - 1.2e-43 149.1 1.5 1.5e-43 148.7 1.5 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK87896.1 - 7e-21 75.4 0.1 1.1e-20 74.7 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Pkinase PF00069.25 VDK87900.1 - 4.1e-42 144.4 0.1 7.2e-42 143.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87900.1 - 4.4e-20 72.1 0.1 5.6e-20 71.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK87900.1 - 4.8e-10 39.2 0.1 8.2e-10 38.5 0.1 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK87900.1 - 0.00039 19.8 0.2 0.039 13.3 0.0 2.4 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family zf-RING_5 PF14634.6 VDK87901.1 - 1.3e-07 31.4 11.5 2.7e-07 30.4 11.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK87901.1 - 0.043 13.7 8.6 0.091 12.6 8.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Exonuc_VII_L PF02601.15 VDK87901.1 - 0.15 11.6 4.4 0.19 11.3 4.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C3HC4 PF00097.25 VDK87901.1 - 0.32 10.9 9.3 0.05 13.5 4.5 2.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 VDK87901.1 - 0.34 11.1 4.8 0.72 10.0 4.8 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 DUF724 PF05266.14 VDK87901.1 - 1.4 8.7 9.0 2.4 7.9 9.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Syntaxin-18_N PF10496.9 VDK87901.1 - 1.7 8.9 5.6 2.8 8.3 3.7 2.3 2 1 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus HutD PF05962.11 VDK87901.1 - 1.9 8.4 4.8 0.89 9.5 1.0 2.0 2 0 0 2 2 2 0 HutD zf-RING_6 PF14835.6 VDK87901.1 - 4.5 7.2 6.8 1.6 8.7 2.6 2.3 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Myc-LZ PF02344.15 VDK87901.1 - 4.8 7.4 9.3 17 5.6 4.7 2.7 2 0 0 2 2 2 0 Myc leucine zipper domain zf-C3HC4_2 PF13923.6 VDK87901.1 - 8.6 6.3 12.5 3.9 7.4 9.4 2.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) VWC PF00093.18 VDK87902.1 - 2.4e-28 98.2 229.9 1.5e-09 38.0 13.3 12.4 8 2 4 12 12 12 7 von Willebrand factor type C domain Antistasin PF02822.14 VDK87902.1 - 6e-11 42.8 43.0 3.1e-06 27.7 10.6 13.9 17 1 0 17 17 17 3 Antistasin family TILa PF12714.7 VDK87902.1 - 0.00036 20.4 29.6 0.0009 19.2 9.7 12.0 12 2 0 13 13 13 6 TILa domain 7tm_1 PF00001.21 VDK87907.1 - 7.5e-05 22.2 24.0 0.00063 19.1 24.0 2.0 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) AAA PF00004.29 VDK87909.1 - 1.5e-41 141.9 0.0 2.6e-41 141.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 VDK87909.1 - 1e-25 89.5 0.6 5e-25 87.3 0.1 2.4 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 VDK87909.1 - 8.2e-09 35.1 0.0 2.3e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 VDK87909.1 - 5.2e-06 26.8 0.1 0.0027 18.0 0.2 2.6 2 1 0 2 2 1 1 AAA domain AAA_5 PF07728.14 VDK87909.1 - 8.6e-06 25.8 0.0 2.5e-05 24.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 VDK87909.1 - 3.4e-05 23.6 0.0 5.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 VDK87909.1 - 3.7e-05 24.2 0.0 0.0078 16.6 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 VDK87909.1 - 6.4e-05 22.3 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 VDK87909.1 - 6.8e-05 22.9 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 VDK87909.1 - 0.00011 22.0 0.0 0.00022 21.0 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 VDK87909.1 - 0.00011 22.4 0.0 0.00033 20.8 0.0 1.7 1 1 1 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 VDK87909.1 - 0.00064 20.3 0.0 0.0014 19.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 VDK87909.1 - 0.00073 19.9 0.1 0.016 15.6 0.0 2.4 2 0 0 2 2 2 1 RNA helicase TniB PF05621.11 VDK87909.1 - 0.0037 16.7 0.0 1.2 8.5 0.0 2.5 1 1 1 2 2 2 1 Bacterial TniB protein DUF815 PF05673.13 VDK87909.1 - 0.0037 16.4 0.0 0.0052 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 VDK87909.1 - 0.0038 17.4 0.0 0.011 16.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 VDK87909.1 - 0.0087 15.8 0.0 0.018 14.8 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 VDK87909.1 - 0.011 16.1 0.0 0.047 14.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 VDK87909.1 - 0.012 15.0 0.3 1.1 8.5 0.1 2.3 1 1 1 2 2 2 0 KaiC AAA_7 PF12775.7 VDK87909.1 - 0.013 15.0 0.0 0.039 13.5 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 VDK87909.1 - 0.016 14.8 0.1 1.7 8.2 0.1 2.4 1 1 1 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 VDK87909.1 - 0.022 14.9 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 VDK87909.1 - 0.025 14.3 0.0 0.11 12.2 0.0 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 VDK87909.1 - 0.029 13.7 0.1 1.4 8.2 0.0 2.6 2 1 1 3 3 3 0 Zeta toxin PhoH PF02562.16 VDK87909.1 - 0.03 13.8 0.0 0.061 12.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Mg_chelatase PF01078.21 VDK87909.1 - 0.031 13.7 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 VDK87909.1 - 0.068 13.1 0.0 1.6 8.6 0.0 2.4 1 1 1 2 2 2 0 NACHT domain AAA_30 PF13604.6 VDK87909.1 - 0.082 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Guanylate_kin PF00625.21 VDK87909.1 - 0.11 12.2 0.0 0.62 9.7 0.0 2.1 1 1 2 3 3 3 0 Guanylate kinase ATPase_2 PF01637.18 VDK87909.1 - 0.12 12.3 0.0 1.3 8.9 0.0 2.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 VDK87909.1 - 0.18 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AA_permease_2 PF13520.6 VDK87910.1 - 4.6e-68 230.0 49.9 5.4e-68 229.8 49.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 VDK87910.1 - 4.8e-30 104.6 41.8 7.7e-30 103.9 41.8 1.3 1 1 0 1 1 1 1 Amino acid permease DOMON PF03351.17 VDK87911.1 - 6.3e-10 39.3 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 VDK87911.1 - 1.6e-06 28.3 3.5 1.6e-06 28.3 3.5 2.2 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 SUR7 PF06687.12 VDK87911.1 - 0.44 10.1 11.8 0.75 9.4 0.0 3.7 2 1 1 3 3 3 0 SUR7/PalI family Phosphodiest PF01663.22 VDK87918.1 - 8.6e-15 55.2 0.1 2.1e-14 53.9 0.1 1.6 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 VDK87918.1 - 0.00057 19.3 0.2 0.001 18.5 0.2 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 VDK87918.1 - 0.03 13.7 0.0 0.12 11.8 0.0 1.8 1 1 1 2 2 2 0 Sulfatase Motile_Sperm PF00635.26 VDK87919.1 - 3.3e-30 104.1 0.1 5.4e-30 103.4 0.1 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF4440 PF14534.6 VDK87920.1 - 0.0013 19.1 0.0 0.0017 18.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 VDK87920.1 - 0.0053 17.4 0.0 0.0078 16.8 0.0 1.3 1 0 0 1 1 1 1 SnoaL-like domain DUF536 PF04394.14 VDK87920.1 - 0.37 10.7 4.9 0.78 9.7 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function, DUF536 Arrestin_C PF02752.22 VDK87928.1 - 1.9e-16 60.8 0.1 3.1e-13 50.4 0.0 2.4 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 VDK87928.1 - 3.8e-14 53.0 0.1 6.9e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain ubiquitin PF00240.23 VDK87930.1 - 4.4e-08 32.8 0.0 7.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 VDK87930.1 - 2.5e-05 24.8 0.1 6.3e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 VDK87930.1 - 0.00011 22.2 0.0 0.0002 21.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF4381 PF14316.6 VDK87930.1 - 0.072 13.3 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Thioredoxin PF00085.20 VDK87931.1 - 2.1e-23 82.3 0.0 2e-22 79.1 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_6 PF13848.6 VDK87931.1 - 2.9e-14 53.4 0.0 8.7e-09 35.5 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 VDK87931.1 - 0.00011 22.6 0.2 0.0036 17.7 0.1 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK87931.1 - 0.088 13.1 0.6 5.3 7.4 0.0 3.1 3 1 1 4 4 4 0 Thioredoxin-like Thioredoxin_7 PF13899.6 VDK87931.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like Ribosomal_S8 PF00410.19 VDK87932.1 - 2.1e-22 79.4 0.0 2.7e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 SHS2_Rpb7-N PF03876.17 VDK87934.1 - 9.6e-16 57.9 0.0 2.1e-15 56.8 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 VDK87934.1 - 5.2e-15 55.6 0.0 1.4e-14 54.2 0.0 1.8 1 0 0 1 1 1 1 S1 RNA binding domain Peptidase_S24 PF00717.23 VDK87934.1 - 1.3e-09 37.8 0.6 2.9e-09 36.8 0.1 1.9 2 0 0 2 2 2 1 Peptidase S24-like RNA_pol_Rbc25 PF08292.12 VDK87934.1 - 0.029 14.6 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 WD40 PF00400.32 VDK87936.1 - 3.3e-16 59.4 15.8 0.0022 18.8 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK87936.1 - 2.8e-09 37.2 0.4 0.039 14.3 0.0 3.7 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 VDK87936.1 - 6.3e-06 25.7 0.4 0.013 14.9 0.0 2.7 2 1 1 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 VDK87936.1 - 0.021 13.4 0.0 1.1 7.7 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain SUKH_6 PF14568.6 VDK87936.1 - 0.078 13.4 0.1 5.2 7.5 0.0 2.4 1 1 1 2 2 2 0 SMI1-KNR4 cell-wall PQQ_2 PF13360.6 VDK87936.1 - 0.12 11.9 0.0 1.4 8.5 0.0 2.1 2 0 0 2 2 2 0 PQQ-like domain Enolase_C PF00113.22 VDK87941.1 - 1.4e-130 434.9 0.8 1.9e-130 434.4 0.8 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 VDK87941.1 - 2.6e-56 189.4 0.0 5.1e-56 188.4 0.0 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 VDK87941.1 - 2.7e-05 23.8 0.0 3.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 VDK87941.1 - 7.5e-05 22.0 0.3 0.00014 21.1 0.1 1.7 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus IMS PF00817.20 VDK87941.1 - 0.11 12.5 0.0 0.34 10.9 0.0 1.8 2 0 0 2 2 2 0 impB/mucB/samB family Homeodomain PF00046.29 VDK87945.1 - 3.8e-22 77.9 4.3 6.7e-22 77.1 4.3 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK87945.1 - 0.0044 16.9 0.3 0.0044 16.9 0.3 2.3 3 0 0 3 3 3 1 Homeobox KN domain Ephrin_rec_like PF07699.13 VDK87946.1 - 1.2e-25 88.9 37.9 9.7e-15 54.1 4.2 4.2 4 0 0 4 4 4 3 Putative ephrin-receptor like EGF PF00008.27 VDK87946.1 - 6.9e-09 35.9 16.5 1.8e-05 24.9 5.1 6.4 6 3 0 6 6 6 2 EGF-like domain EGF_3 PF12947.7 VDK87946.1 - 3.3e-07 30.4 6.2 3.3e-07 30.4 6.2 4.3 4 0 0 4 4 4 2 EGF domain hEGF PF12661.7 VDK87946.1 - 0.00039 20.9 4.0 0.00039 20.9 4.0 8.9 9 1 0 9 9 9 2 Human growth factor-like EGF DUF2318 PF10080.9 VDK87946.1 - 0.0017 18.4 16.6 0.069 13.3 0.4 3.3 2 1 1 3 3 3 3 Predicted membrane protein (DUF2318) EGF_MSP1_1 PF12946.7 VDK87946.1 - 1.2 9.2 24.9 0.34 11.0 6.2 3.6 3 0 0 3 3 3 0 MSP1 EGF domain 1 TNFR_c6 PF00020.18 VDK87946.1 - 1.4 9.4 43.3 0.58 10.6 0.2 7.6 5 3 2 7 7 7 0 TNFR/NGFR cysteine-rich region CDC24_OB3 PF17244.2 VDK87950.1 - 0.026 14.2 0.0 0.028 14.1 0.0 1.1 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 3 TFIIB PF00382.19 VDK87951.1 - 2e-30 104.6 0.4 8.5e-14 51.4 0.0 2.7 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 VDK87951.1 - 3.7e-24 85.0 9.9 3.7e-24 85.0 9.9 3.2 4 0 0 4 4 4 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 VDK87951.1 - 2e-11 43.2 2.5 4.2e-11 42.2 2.5 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 VDK87951.1 - 1.6e-06 27.9 0.2 0.00058 19.6 0.0 2.8 2 0 0 2 2 2 2 Cyclin, N-terminal domain 2Fe-2S_thioredx PF01257.19 VDK87951.1 - 0.077 12.9 0.1 0.21 11.4 0.1 1.7 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin Ribosomal_S27e PF01667.17 VDK87951.1 - 0.081 12.6 0.2 0.18 11.5 0.2 1.5 1 0 0 1 1 1 0 Ribosomal protein S27 zf-ribbon_3 PF13248.6 VDK87951.1 - 0.37 10.3 5.0 2.1 7.8 5.0 2.1 1 1 0 1 1 1 0 zinc-ribbon domain CUB PF00431.20 VDK87955.1 - 1.4e-05 25.4 0.0 2.7e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 CUB domain APOC4 PF15119.6 VDK87956.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein C4 Patatin PF01734.22 VDK87959.1 - 4e-15 56.5 0.7 2.8e-12 47.2 0.4 3.0 2 1 0 2 2 2 1 Patatin-like phospholipase Pkinase PF00069.25 VDK87961.1 - 2e-70 237.2 0.0 2.7e-70 236.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK87961.1 - 4.1e-34 118.1 0.0 1e-33 116.7 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK87961.1 - 1.6e-07 30.9 0.0 2.7e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 VDK87961.1 - 8.6e-05 21.6 0.0 0.0012 17.9 0.0 2.3 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 VDK87961.1 - 0.00064 19.1 0.7 0.0017 17.7 0.7 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK87961.1 - 0.004 17.1 0.2 0.012 15.6 0.1 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 VDK87961.1 - 0.024 13.7 0.0 0.058 12.4 0.0 1.5 1 1 0 1 1 1 0 Seadornavirus VP7 MARVEL PF01284.23 VDK87964.1 - 4.2e-13 49.5 7.7 5.5e-13 49.2 7.7 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF2207 PF09972.9 VDK87964.1 - 0.03 13.1 1.9 1.1 7.9 0.0 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Mob1_phocein PF03637.17 VDK87965.1 - 4.8e-45 153.6 0.1 6.5e-45 153.2 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family EF-hand_1 PF00036.32 VDK87966.1 - 1.2e-17 62.0 17.2 0.0025 17.3 0.7 6.6 6 0 0 6 6 6 6 EF hand EF-hand_7 PF13499.6 VDK87966.1 - 3.6e-16 59.4 22.6 8.9e-06 26.1 2.4 3.7 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 VDK87966.1 - 6.8e-15 53.7 17.2 0.00015 21.4 0.3 6.2 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 VDK87966.1 - 6.6e-12 44.4 20.5 0.0034 16.8 1.0 5.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 VDK87966.1 - 2.6e-06 27.2 13.4 0.21 11.4 0.1 5.5 5 0 0 5 5 5 4 EF-hand domain pair EF-hand_10 PF14788.6 VDK87966.1 - 0.34 10.8 2.9 28 4.7 0.1 3.9 3 1 1 4 4 4 0 EF hand Cyanate_lyase PF02560.14 VDK87967.1 - 3.5e-32 110.1 0.0 6.6e-32 109.2 0.0 1.5 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_3 PF01381.22 VDK87967.1 - 0.09 12.8 0.2 1.1 9.4 0.1 2.4 3 0 0 3 3 3 0 Helix-turn-helix DUF4983 PF16356.5 VDK87967.1 - 0.13 13.1 0.0 0.21 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4983) RA PF00788.23 VDK87969.1 - 0.00021 21.9 0.0 0.00039 21.0 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain RILP PF11461.8 VDK87969.1 - 0.0055 16.9 0.8 0.016 15.4 0.8 1.8 1 0 0 1 1 1 1 Rab interacting lysosomal protein CorA PF01544.18 VDK87969.1 - 4.5 6.5 7.7 18 4.5 7.2 2.0 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Mtc PF03820.17 VDK87970.1 - 1.2e-130 435.1 0.2 1.4e-130 434.9 0.2 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier I-set PF07679.16 VDK87971.1 - 0.0011 19.0 0.0 0.0026 17.8 0.0 1.6 1 1 0 1 1 1 1 Immunoglobulin I-set domain FUR PF01475.19 VDK87971.1 - 0.023 14.9 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 Ferric uptake regulator family Ig_3 PF13927.6 VDK87971.1 - 0.024 15.2 0.0 0.058 14.0 0.0 1.6 1 0 0 1 1 1 0 Immunoglobulin domain tRNA_Me_trans PF03054.16 VDK87978.1 - 3.2e-108 361.7 0.0 3.6e-108 361.5 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 VDK87978.1 - 4.3e-09 36.2 0.1 2.9e-08 33.5 0.0 2.1 2 1 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.17 VDK87978.1 - 8.3e-05 21.8 0.0 0.0029 16.8 0.0 2.2 2 0 0 2 2 2 1 NAD synthase ATP_bind_3 PF01171.20 VDK87978.1 - 0.0022 17.8 0.0 0.0037 17.1 0.0 1.5 1 1 0 1 1 1 1 PP-loop family QueC PF06508.13 VDK87978.1 - 0.0073 15.8 0.0 0.025 14.1 0.0 1.8 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC SRCR PF00530.18 VDK87978.1 - 0.018 15.5 0.0 0.052 14.0 0.0 1.7 1 0 0 1 1 1 0 Scavenger receptor cysteine-rich domain Asn_synthase PF00733.21 VDK87978.1 - 0.042 13.5 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase UPF0240 PF06784.11 VDK87979.1 - 6.7e-07 29.5 17.3 7.1e-06 26.2 8.1 3.1 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0240) KIAA1430 PF13879.6 VDK87979.1 - 0.0091 16.7 3.1 0.0091 16.7 3.1 2.6 2 1 0 2 2 2 1 KIAA1430 homologue KN_motif PF12075.8 VDK87979.1 - 0.15 11.9 0.3 0.74 9.7 0.0 2.2 2 0 0 2 2 2 0 KN motif zf-BED PF02892.15 VDK87979.1 - 0.35 10.9 1.3 0.66 10.1 0.2 2.0 2 0 0 2 2 2 0 BED zinc finger SWIM PF04434.17 VDK87980.1 - 0.029 14.0 0.1 0.065 12.9 0.1 1.6 1 0 0 1 1 1 0 SWIM zinc finger CG-1 PF03859.16 VDK87980.1 - 0.061 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 CG-1 domain Guanylate_kin PF00625.21 VDK87986.1 - 8.8e-51 172.2 1.7 1e-50 172.0 0.7 1.6 2 0 0 2 2 2 1 Guanylate kinase VGCC_beta4Aa_N PF12052.8 VDK87986.1 - 7.7e-18 64.3 5.8 7.7e-18 64.3 5.8 2.3 2 0 0 2 2 2 1 Voltage gated calcium channel subunit beta domain 4Aa N terminal SH3_1 PF00018.28 VDK87986.1 - 0.0042 16.7 0.1 0.0084 15.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK87986.1 - 0.049 13.3 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 Variant SH3 domain Amino_oxidase PF01593.24 VDK87987.1 - 1.7e-60 205.6 0.0 1.9e-60 205.5 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Lgl_C PF08596.10 VDK87992.1 - 0.0058 15.4 0.0 0.087 11.5 0.0 2.4 2 1 1 3 3 3 1 Lethal giant larvae(Lgl) like, C-terminal Synaptobrevin PF00957.21 VDK87992.1 - 0.045 13.6 0.5 0.1 12.4 0.5 1.5 1 0 0 1 1 1 0 Synaptobrevin Ribosomal_L14e PF01929.17 VDK87994.1 - 8.7e-08 32.6 11.4 5.9e-05 23.5 2.8 2.5 2 1 1 3 3 3 2 Ribosomal protein L14 Pox_L3_FP4 PF03339.14 VDK87994.1 - 0.3 10.1 1.4 2.7 6.9 0.1 2.0 1 1 1 2 2 2 0 Poxvirus L3/FP4 protein LETM1 PF07766.13 VDK87995.1 - 2e-22 79.8 10.5 1.8e-16 60.3 1.7 2.1 1 1 1 2 2 2 2 LETM1-like protein ER PF01133.17 VDK87999.1 - 6.7e-42 141.5 0.1 8.2e-42 141.2 0.1 1.1 1 0 0 1 1 1 1 Enhancer of rudimentary BRO1 PF03097.18 VDK88000.1 - 7.2e-89 298.3 0.4 7.2e-89 298.3 0.4 1.6 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 VDK88000.1 - 3.1e-26 92.4 8.7 3.1e-26 92.4 8.7 2.0 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV BioW PF03744.13 VDK88000.1 - 0.092 12.3 1.0 0.27 10.8 0.1 2.0 2 0 0 2 2 2 0 6-carboxyhexanoate--CoA ligase V-SNARE_C PF12352.8 VDK88004.1 - 2.3e-17 63.0 8.7 5.6e-17 61.8 8.7 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 VDK88004.1 - 5.2e-12 46.0 2.2 5.2e-12 46.0 2.2 2.5 1 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 VDK88004.1 - 2e-05 24.4 3.6 2e-05 24.4 3.6 2.4 2 1 1 3 3 3 1 Sec20 Tropomyosin_1 PF12718.7 VDK88004.1 - 0.012 15.8 13.1 0.068 13.3 13.3 2.0 1 1 1 2 2 2 0 Tropomyosin like TssC PF17541.2 VDK88004.1 - 0.012 14.5 6.0 0.0085 15.0 3.3 1.8 1 1 1 2 2 2 0 Type VI secretion system, TssC, VipB MFS_2 PF13347.6 VDK88004.1 - 0.015 13.8 0.2 0.02 13.5 0.2 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein V_ATPase_I PF01496.19 VDK88004.1 - 1.5 6.7 6.2 1.7 6.4 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF745 PF05335.13 VDK88004.1 - 1.7 8.3 8.1 7 6.3 2.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) MctB PF11382.8 VDK88004.1 - 2.9 7.5 6.5 0.29 10.8 1.0 1.9 1 1 1 2 2 2 0 Copper transport outer membrane protein, MctB Ribosomal_S7 PF00177.21 VDK88005.1 - 8.9e-25 87.1 0.0 5.5e-24 84.5 0.0 2.1 2 1 0 2 2 2 1 Ribosomal protein S7p/S5e HTH_19 PF12844.7 VDK88006.1 - 0.033 14.2 1.1 1 9.4 0.1 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain 4_1_CTD PF05902.13 VDK88013.1 - 2.6e-30 104.6 4.6 2.6e-30 104.6 4.6 2.8 3 0 0 3 3 3 1 4.1 protein C-terminal domain (CTD) PEPCK_GTP PF00821.18 VDK88014.1 - 1e-163 544.3 0.9 1.3e-163 544.0 0.9 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 VDK88014.1 - 2.1e-96 321.7 0.0 2.9e-96 321.3 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain Mesothelin PF06060.12 VDK88014.1 - 0.21 9.7 0.0 0.31 9.2 0.0 1.1 1 0 0 1 1 1 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) Neur_chan_memb PF02932.16 VDK88015.1 - 1.1e-24 87.8 11.2 3.8e-16 59.9 7.0 2.2 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 VDK88015.1 - 4.8e-06 26.2 0.0 7.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain zf-RanBP PF00641.18 VDK88023.1 - 5.2e-07 28.9 22.3 6e-05 22.3 8.2 2.6 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others PKcGMP_CC PF16808.5 VDK88026.1 - 0.02 14.7 2.5 0.02 14.7 2.5 7.5 7 1 0 7 7 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SRP19 PF01922.17 VDK88026.1 - 0.034 15.1 1.2 0.034 15.1 1.2 2.6 2 0 0 2 2 2 0 SRP19 protein DcrB PF08786.11 VDK88026.1 - 0.083 13.0 7.1 2.7 8.1 1.8 3.2 1 1 1 2 2 2 0 DcrB GIT_CC PF16559.5 VDK88026.1 - 8 6.4 27.1 0.09 12.7 5.5 6.0 5 1 1 6 6 6 0 GIT coiled-coil Rho guanine nucleotide exchange factor TMEM164 PF14808.6 VDK88032.1 - 1e-85 287.2 6.2 1.2e-85 287.0 6.2 1.0 1 0 0 1 1 1 1 TMEM164 family DUF4713 PF15831.5 VDK88032.1 - 0.0024 18.3 0.3 0.0024 18.3 0.3 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4713) PBP PF01161.20 VDK88033.1 - 8.5e-22 77.9 0.0 1.3e-21 77.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Pyr_redox_2 PF07992.14 VDK88034.1 - 2.7e-45 154.9 0.0 9.4e-45 153.1 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AIF_C PF14721.6 VDK88034.1 - 1.6e-22 80.2 4.6 2e-14 54.0 0.0 2.9 2 1 1 3 3 3 2 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox PF00070.27 VDK88034.1 - 2e-07 31.5 0.0 1.2e-06 29.0 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 VDK88034.1 - 0.00025 19.9 0.0 0.021 13.5 0.0 3.0 3 0 0 3 3 3 1 HI0933-like protein K_oxygenase PF13434.6 VDK88034.1 - 0.0023 17.1 0.0 0.01 15.0 0.0 1.8 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) DUF2525 PF10733.9 VDK88034.1 - 0.1 12.9 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2525) Deltameth_res PF16020.5 VDK88034.1 - 0.12 12.3 0.2 0.3 11.0 0.2 1.7 1 0 0 1 1 1 0 Deltamethrin resistance Reductase_C PF14759.6 VDK88034.1 - 0.15 12.6 0.0 0.51 10.9 0.0 2.0 1 0 0 1 1 1 0 Reductase C-terminal FCH PF00611.23 VDK88038.1 - 0.0036 17.5 2.3 0.0036 17.5 2.3 2.6 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF1938 PF09153.10 VDK88038.1 - 0.047 13.8 0.1 0.35 11.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1938) LZ3wCH PF18517.1 VDK88038.1 - 0.14 12.3 2.4 0.14 12.3 0.0 2.2 2 0 0 2 2 2 0 Leucine zipper with capping helix domain Fib_alpha PF08702.10 VDK88038.1 - 2.9 8.1 9.4 1.1 9.4 0.2 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 VDK88038.1 - 4.5 5.1 9.3 5.7 4.7 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family COBRA1 PF06209.13 VDK88042.1 - 3e-65 221.0 4.8 1.6e-59 202.0 3.2 2.2 1 1 1 2 2 2 2 Cofactor of BRCA1 (COBRA1) MGAT2 PF05060.14 VDK88044.1 - 2.6e-143 477.3 5.3 3.1e-143 477.1 5.3 1.0 1 0 0 1 1 1 1 N-acetylglucosaminyltransferase II (MGAT2) DUF4293 PF14126.6 VDK88045.1 - 0.14 12.4 8.0 0.023 15.0 3.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) EGF PF00008.27 VDK88050.1 - 0.012 15.9 7.8 0.027 14.8 7.8 1.6 1 0 0 1 1 1 0 EGF-like domain Flu_M2 PF00599.17 VDK88050.1 - 0.023 14.8 0.4 0.082 13.0 0.1 2.0 2 1 0 2 2 2 0 Influenza Matrix protein (M2) Orai-1 PF07856.12 VDK88050.1 - 0.032 13.9 0.4 0.057 13.1 0.4 1.3 1 0 0 1 1 1 0 Mediator of CRAC channel activity Syndecan PF01034.20 VDK88050.1 - 0.16 11.9 1.1 0.33 10.9 1.1 1.5 1 0 0 1 1 1 0 Syndecan domain PX PF00787.24 VDK88052.1 - 3.3e-13 49.6 0.4 6e-13 48.8 0.4 1.5 1 1 0 1 1 1 1 PX domain CECR6_TMEM121 PF14997.6 VDK88053.1 - 1.1e-26 93.9 11.0 6.1e-19 68.6 2.7 2.7 1 1 2 3 3 3 2 CECR6/TMEM121 family RWD PF05773.22 VDK88058.1 - 0.02 15.2 0.0 0.021 15.1 0.0 1.1 1 0 0 1 1 1 0 RWD domain Frankia_peptide PF14407.6 VDK88058.1 - 0.074 13.0 0.0 0.093 12.7 0.0 1.2 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. MoaE PF02391.17 VDK88059.1 - 0.06 13.6 0.0 0.071 13.4 0.0 1.0 1 0 0 1 1 1 0 MoaE protein Mito_carr PF00153.27 VDK88061.1 - 6.1e-63 208.8 2.2 8.5e-20 70.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DJ-1_PfpI PF01965.24 VDK88062.1 - 4.2e-50 169.8 0.1 4.9e-50 169.6 0.1 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 VDK88062.1 - 0.015 14.9 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain EB PF01683.18 VDK88063.1 - 1.8e-12 47.4 30.5 2.6e-06 27.6 5.3 2.5 2 1 1 3 3 3 2 EB module EGF_MSP1_1 PF12946.7 VDK88063.1 - 0.00074 19.5 12.8 0.00074 19.5 12.8 3.7 2 2 1 3 3 3 1 MSP1 EGF domain 1 cEGF PF12662.7 VDK88063.1 - 0.12 12.3 12.3 1.3 9.0 1.3 2.9 2 0 0 2 2 2 0 Complement Clr-like EGF-like EB PF01683.18 VDK88064.1 - 1.8e-13 50.5 39.4 3e-07 30.6 9.0 3.2 1 1 2 3 3 3 3 EB module Tubulin PF00091.25 VDK88065.1 - 4.3e-59 200.0 0.0 3.8e-58 196.9 0.0 2.1 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDK88065.1 - 3.7e-41 140.2 0.0 5.7e-41 139.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 VDK88065.1 - 1.1e-05 25.6 0.0 3.3e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 VDK88065.1 - 0.026 13.7 0.0 0.053 12.7 0.0 1.5 1 0 0 1 1 1 0 Tubulin like Neur_chan_LBD PF02931.23 VDK88067.1 - 1.7e-28 99.5 3.7 2.3e-28 99.1 3.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Pkinase PF00069.25 VDK88069.1 - 1.1e-11 44.6 0.0 1.4e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK88069.1 - 9.5e-07 28.4 0.0 1.2e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK88069.1 - 0.0015 17.4 0.0 0.0026 16.6 0.0 1.3 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK88069.1 - 0.0034 17.3 0.0 0.45 10.4 0.0 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family PIP49_C PF12260.8 VDK88069.1 - 0.0072 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Fructosamin_kin PF03881.14 VDK88069.1 - 0.058 12.6 0.0 0.096 11.9 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase Acyltransferase PF01553.21 VDK88071.1 - 9.9e-11 41.4 0.0 2e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase CKS PF01111.19 VDK88078.1 - 1.7e-36 124.3 2.8 1.9e-36 124.1 2.8 1.0 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit SART-1 PF03343.13 VDK88079.1 - 3e-122 409.3 66.9 3e-122 409.3 66.9 2.1 2 0 0 2 2 2 1 SART-1 family BRE1 PF08647.11 VDK88079.1 - 0.0011 19.0 5.0 0.0011 19.0 5.0 4.0 3 1 1 4 4 4 1 BRE1 E3 ubiquitin ligase Cation_efflux PF01545.21 VDK88080.1 - 8.1e-49 166.1 12.8 9.8e-49 165.8 12.8 1.1 1 0 0 1 1 1 1 Cation efflux family DUF4006 PF13179.6 VDK88080.1 - 0.88 9.5 5.5 2.3 8.2 0.4 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF4006) PHO4 PF01384.20 VDK88080.1 - 1.6 7.7 4.1 2.1 7.3 4.1 1.2 1 0 0 1 1 1 0 Phosphate transporter family Peptidase_M48_N PF16491.5 VDK88080.1 - 8.7 6.2 8.5 9.7 6.0 3.8 2.5 2 1 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices ANAPC4_WD40 PF12894.7 VDK88084.1 - 5.1e-06 26.7 0.3 0.045 14.0 0.1 4.8 3 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 VDK88084.1 - 0.00083 19.2 0.1 0.062 13.1 0.0 2.9 3 0 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 VDK88084.1 - 0.019 14.9 0.0 22 5.1 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 VDK88084.1 - 0.055 14.4 7.7 60 4.7 0.0 5.0 5 0 0 5 5 5 0 WD domain, G-beta repeat Vps16_N PF04841.13 VDK88084.1 - 0.26 10.0 3.4 0.44 9.3 3.1 1.5 1 1 0 1 1 1 0 Vps16, N-terminal region Aa_trans PF01490.18 VDK88085.1 - 2.6e-50 171.3 26.6 2.2e-29 102.4 13.3 2.0 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Ribosomal_L15e PF00827.17 VDK88086.1 - 1.7e-91 305.1 11.6 2e-91 304.9 11.6 1.0 1 0 0 1 1 1 1 Ribosomal L15 DEAD PF00270.29 VDK88087.1 - 6.9e-15 55.2 0.0 1.4e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase OMPdecase PF00215.24 VDK88091.1 - 2.1e-45 155.1 0.4 3.2e-45 154.5 0.4 1.3 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 VDK88091.1 - 4.5e-13 49.0 0.0 9.3e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain AsnC_trans_reg PF01037.21 VDK88091.1 - 0.012 15.6 0.0 0.13 12.3 0.0 2.4 2 0 0 2 2 2 0 Lrp/AsnC ligand binding domain TctB PF07331.11 VDK88093.1 - 3.1 8.1 8.7 4.5 7.5 1.2 2.4 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF2052 PF09747.9 VDK88094.1 - 5e-36 124.7 16.6 5e-36 124.7 16.6 1.5 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) PPP5 PF08321.12 VDK88094.1 - 0.04 14.2 1.1 0.1 12.9 0.2 2.0 2 0 0 2 2 2 0 PPP5 TPR repeat region PVL_ORF50 PF07768.11 VDK88094.1 - 0.25 11.6 7.8 0.047 14.0 3.7 1.8 2 0 0 2 2 2 0 PVL ORF-50-like family Ribosomal_L18A PF01775.17 VDK88095.1 - 8.7e-54 180.8 0.8 1.1e-53 180.4 0.8 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF5496 PF17600.2 VDK88095.1 - 0.1 12.7 0.2 0.26 11.4 0.1 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5496) WD40 PF00400.32 VDK88096.1 - 0.0055 17.5 0.0 3.5 8.6 0.1 4.0 5 0 0 5 5 5 1 WD domain, G-beta repeat CEBP_ZZ PF16366.5 VDK88103.1 - 1.3e-17 63.8 4.2 4.4e-16 58.9 3.3 2.2 2 0 0 2 2 2 1 Cytoplasmic polyadenylation element-binding protein ZZ domain RRM_1 PF00076.22 VDK88103.1 - 4e-06 26.6 0.0 6.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 VDK88103.1 - 0.00097 19.2 0.0 1.9 8.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif zf-B_box PF00643.24 VDK88103.1 - 0.059 13.5 2.7 0.12 12.5 2.7 1.5 1 0 0 1 1 1 0 B-box zinc finger RRM_7 PF16367.5 VDK88104.1 - 0.011 15.8 0.1 0.021 14.9 0.1 1.5 1 0 0 1 1 1 0 RNA recognition motif FA PF08736.11 VDK88104.1 - 0.043 13.9 0.0 0.065 13.3 0.0 1.3 1 0 0 1 1 1 0 FERM adjacent (FA) LIM PF00412.22 VDK88105.1 - 1.2e-13 51.0 4.9 1.6e-13 50.6 4.9 1.2 1 0 0 1 1 1 1 LIM domain COX6B PF02297.17 VDK88112.1 - 1.9e-10 40.8 2.9 3e-10 40.2 2.9 1.4 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb SLBP_RNA_bind PF15247.6 VDK88112.1 - 0.24 11.5 3.5 0.31 11.2 1.6 2.1 2 1 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain Utp11 PF03998.13 VDK88113.1 - 1.8e-62 211.5 22.6 2e-62 211.3 22.6 1.0 1 0 0 1 1 1 1 Utp11 protein Ribosomal_S2 PF00318.20 VDK88113.1 - 0.14 11.4 3.8 0.53 9.5 3.8 2.0 1 1 0 1 1 1 0 Ribosomal protein S2 NUFIP1 PF10453.9 VDK88113.1 - 6.1 6.8 8.2 16 5.4 0.4 3.9 3 1 0 3 3 3 0 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Ras PF00071.22 VDK88117.1 - 3.1e-39 134.2 0.0 3.9e-39 133.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK88117.1 - 3e-27 95.2 0.0 4.9e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK88117.1 - 2.3e-11 43.4 0.0 3.8e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK88117.1 - 0.0041 16.5 0.0 0.0078 15.6 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 VDK88117.1 - 0.011 14.5 0.0 0.64 8.8 0.0 2.3 2 1 0 2 2 2 0 Dynein light intermediate chain (DLIC) DNA_pol_E_B PF04042.16 VDK88117.1 - 0.012 15.0 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B PduV-EutP PF10662.9 VDK88117.1 - 0.015 15.1 0.0 0.046 13.5 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FtsZ_C PF12327.8 VDK88117.1 - 0.063 13.6 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 FtsZ family, C-terminal domain AAA_22 PF13401.6 VDK88117.1 - 0.063 13.5 0.0 1.1 9.5 0.0 2.3 1 1 0 1 1 1 0 AAA domain ProRS-C_1 PF09180.11 VDK88117.1 - 0.11 12.7 0.0 7.9 6.8 0.0 2.5 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Forkhead PF00250.18 VDK88118.1 - 8.4e-29 99.7 0.4 2.3e-28 98.3 0.1 1.9 2 0 0 2 2 2 1 Forkhead domain FOXP-CC PF16159.5 VDK88118.1 - 9.1e-11 42.2 5.7 9.1e-11 42.2 5.7 2.3 2 0 0 2 2 2 1 FOXP coiled-coil domain Pex14_N PF04695.13 VDK88118.1 - 4.7 7.8 14.2 2.5 8.7 9.9 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ERCC4 PF02732.15 VDK88119.1 - 5.9e-17 62.3 0.2 1.4e-16 61.1 0.2 1.7 1 0 0 1 1 1 1 ERCC4 domain SRI PF08236.11 VDK88119.1 - 8.1e-11 41.9 0.2 2.3e-10 40.5 0.2 1.7 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain WW PF00397.26 VDK88119.1 - 2.1e-08 34.1 0.4 4.6e-08 33.0 0.4 1.6 1 0 0 1 1 1 1 WW domain HHH_8 PF14716.6 VDK88119.1 - 0.0028 18.0 0.0 0.0073 16.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain GreA_GreB_N PF03449.15 VDK88119.1 - 0.08 13.1 1.2 0.26 11.5 1.2 1.8 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal HHH_2 PF12826.7 VDK88119.1 - 0.11 12.6 0.0 0.57 10.3 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif Peptidase_S66C PF17676.1 VDK88119.1 - 0.17 12.4 0.0 0.46 11.0 0.0 1.7 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain HSP20 PF00011.21 VDK88121.1 - 1.2e-22 79.9 0.5 1.6e-22 79.6 0.5 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDK88121.1 - 7.9e-05 22.1 0.1 0.00011 21.7 0.1 1.2 1 0 0 1 1 1 1 HSP20-like domain found in ArsA TTC5_OB PF16669.5 VDK88123.1 - 4e-33 113.5 0.0 6e-33 113.0 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain TPR_1 PF00515.28 VDK88123.1 - 4.3e-11 42.2 1.2 6.2e-05 22.7 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK88123.1 - 1.6e-09 37.1 1.7 0.0062 16.6 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDK88123.1 - 8.2e-09 35.3 0.2 0.0031 17.8 0.0 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK88123.1 - 9.2e-09 34.9 0.1 0.033 13.9 0.0 3.9 3 1 1 4 4 4 3 TPR repeat TPR_14 PF13428.6 VDK88123.1 - 9.1e-06 26.1 0.2 0.72 10.8 0.0 4.7 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK88123.1 - 0.00021 21.2 6.3 0.17 12.2 0.0 5.0 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK88123.1 - 0.0011 19.6 0.0 0.01 16.4 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK88123.1 - 0.0021 18.3 2.8 0.026 14.8 0.1 3.0 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 VDK88123.1 - 0.019 14.9 0.6 0.15 12.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat FAT PF02259.23 VDK88123.1 - 0.024 13.8 0.8 0.13 11.5 0.4 2.2 1 1 1 2 2 2 0 FAT domain ANAPC3 PF12895.7 VDK88123.1 - 0.029 14.6 0.5 1.4 9.2 0.1 2.9 1 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 VDK88123.1 - 0.12 12.9 0.1 4.7 7.8 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2732 PF10809.8 VDK88123.1 - 0.76 9.7 4.5 0.17 11.8 0.4 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2732) EF-hand_4 PF12763.7 VDK88125.1 - 2.6e-11 43.4 0.0 6.7e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 VDK88125.1 - 0.0006 19.2 0.0 0.0013 18.1 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 VDK88125.1 - 0.022 15.2 0.0 0.079 13.4 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 VDK88125.1 - 0.066 13.2 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain PRIMA1 PF16101.5 VDK88125.1 - 6.6 6.8 9.4 11 6.1 1.1 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Ins_P5_2-kin PF06090.12 VDK88128.1 - 3.3e-52 178.0 0.0 4.4e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase PAT1 PF09770.9 VDK88129.1 - 0.0044 15.4 0.2 0.016 13.5 0.1 2.0 2 1 0 2 2 2 1 Topoisomerase II-associated protein PAT1 MAGP PF05507.11 VDK88129.1 - 0.055 13.9 0.0 0.097 13.1 0.0 1.4 1 0 0 1 1 1 0 Microfibril-associated glycoprotein (MAGP) Folate_carrier PF01770.18 VDK88132.1 - 6e-95 318.4 32.6 4.9e-82 275.9 26.9 2.8 1 1 1 2 2 2 2 Reduced folate carrier fn3 PF00041.21 VDK88133.1 - 1.3e-09 38.3 4.0 7.1e-05 23.1 0.1 3.2 3 0 0 3 3 3 3 Fibronectin type III domain Interfer-bind PF09294.10 VDK88133.1 - 4.3e-05 23.8 0.4 0.039 14.3 0.1 2.5 2 0 0 2 2 2 2 Interferon-alpha/beta receptor, fibronectin type III DUF2369 PF10179.9 VDK88133.1 - 0.003 17.9 0.4 0.049 14.0 0.1 2.5 3 0 0 3 3 3 1 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 VDK88133.1 - 0.0033 18.0 1.8 0.72 10.5 0.1 2.5 2 1 0 2 2 2 2 Purple acid Phosphatase, N-terminal domain Glyco_transf_20 PF00982.21 VDK88134.1 - 1.1e-39 136.5 0.0 3.3e-39 134.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 20 T6PP_N PF18572.1 VDK88134.1 - 2.3e-35 120.5 1.2 4.5e-35 119.5 1.2 1.5 1 0 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain S6PP PF05116.13 VDK88135.1 - 0.015 14.9 0.1 0.15 11.6 0.0 1.9 1 1 1 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 VDK88135.1 - 0.075 12.8 0.0 0.089 12.5 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Ras PF00071.22 VDK88136.1 - 6e-42 143.0 0.0 7.1e-42 142.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK88136.1 - 1.6e-18 67.1 0.0 2.4e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK88136.1 - 6.8e-07 28.9 0.0 9.2e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK88136.1 - 1.6e-05 24.6 0.0 3.1e-05 23.6 0.0 1.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDK88136.1 - 0.03 14.4 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase WD40 PF00400.32 VDK88141.1 - 0.00043 21.0 0.0 1.6 9.7 0.0 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK88141.1 - 0.00072 19.8 0.0 0.2 12.0 0.0 3.7 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 VDK88141.1 - 0.022 14.1 0.1 0.068 12.4 0.1 1.8 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller eIF2A PF08662.11 VDK88141.1 - 0.16 11.9 0.0 0.66 9.8 0.0 2.0 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF727 PF05303.12 VDK88144.1 - 5.2e-33 113.2 0.0 8.1e-33 112.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Pkinase_Tyr PF07714.17 VDK88149.1 - 1.6e-82 276.7 0.0 2.2e-82 276.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK88149.1 - 2.1e-41 142.1 0.0 1.8e-26 93.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain APH PF01636.23 VDK88149.1 - 6.1e-05 23.1 0.0 0.00024 21.1 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 VDK88149.1 - 0.00037 19.9 0.0 0.00066 19.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK88149.1 - 0.21 10.9 0.0 0.43 9.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CaiF_GrlA PF07180.11 VDK88153.1 - 0.022 14.8 0.1 0.03 14.3 0.1 1.2 1 0 0 1 1 1 0 CaiF/GrlA transcriptional regulator CCDC32 PF14989.6 VDK88154.1 - 3e-08 33.8 0.6 5.1e-08 33.1 0.6 1.5 1 1 0 1 1 1 1 Coiled-coil domain containing 32 HTH_40 PF14493.6 VDK88154.1 - 0.041 14.3 0.7 0.19 12.2 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain DEAD PF00270.29 VDK88156.1 - 1.4e-43 148.7 0.1 2.5e-43 147.9 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK88156.1 - 1e-31 109.5 0.0 6.3e-31 107.0 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 VDK88156.1 - 8.7e-05 22.9 0.1 0.0058 17.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 VDK88156.1 - 0.00013 21.7 0.0 0.00022 21.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 VDK88156.1 - 0.00071 19.6 0.0 0.0015 18.6 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 VDK88156.1 - 0.0021 16.9 0.0 0.99 8.1 0.0 2.3 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_22 PF13401.6 VDK88156.1 - 0.043 14.1 0.4 0.29 11.4 0.4 2.1 1 1 0 1 1 1 0 AAA domain DUF3419 PF11899.8 VDK88156.1 - 0.083 12.1 0.0 0.75 8.9 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3419) Neur_chan_LBD PF02931.23 VDK88158.1 - 2.7e-40 138.1 4.1 3.6e-40 137.7 4.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK88158.1 - 1.1e-18 68.2 0.1 1.4e-18 67.8 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Tat PF00539.18 VDK88158.1 - 0.51 10.5 2.5 1.3 9.2 2.5 1.7 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) Bromodomain PF00439.25 VDK88160.1 - 3.7e-15 55.8 0.1 9.3e-15 54.5 0.1 1.7 1 0 0 1 1 1 1 Bromodomain Urocanase PF01175.18 VDK88160.1 - 0.021 14.5 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Urocanase Rossmann-like domain HTH_Tnp_Tc3_1 PF11427.8 VDK88160.1 - 0.26 11.2 1.8 0.63 9.9 0.5 2.4 2 0 0 2 2 2 0 Tc3 transposase Amidase PF01425.21 VDK88162.1 - 1.2e-84 284.9 0.0 1.4e-84 284.6 0.0 1.0 1 0 0 1 1 1 1 Amidase Ribosomal_L1 PF00687.21 VDK88165.1 - 1.2e-45 155.7 3.0 1.5e-45 155.4 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family PDZ_6 PF17820.1 VDK88166.1 - 2e-05 24.3 0.1 4.2e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDK88166.1 - 5e-05 23.6 0.0 8.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDK88166.1 - 0.21 12.0 0.0 0.4 11.0 0.0 1.4 1 0 0 1 1 1 0 PDZ domain DAO PF01266.24 VDK88169.1 - 7.8e-28 98.1 0.1 2.8e-26 93.0 0.0 2.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase Prefoldin PF02996.17 VDK88169.1 - 8.4e-19 67.7 4.9 1.5e-17 63.6 0.0 3.3 3 0 0 3 3 3 1 Prefoldin subunit Prefoldin_3 PF13758.6 VDK88169.1 - 0.014 15.4 1.2 0.096 12.8 0.0 2.8 3 0 0 3 3 3 0 Prefoldin subunit GPS2_interact PF15784.5 VDK88169.1 - 0.016 15.6 1.0 0.016 15.6 1.0 2.2 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain NAD_binding_9 PF13454.6 VDK88169.1 - 0.16 12.0 0.1 0.65 10.0 0.1 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding Ras PF00071.22 VDK88170.1 - 2.8e-47 160.3 0.0 3.3e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK88170.1 - 1.7e-32 112.1 0.0 2.2e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK88170.1 - 3.8e-12 46.0 0.0 4.2e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK88170.1 - 7.7e-05 22.7 0.0 0.0001 22.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 VDK88170.1 - 0.00097 18.6 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 VDK88170.1 - 0.0044 16.4 0.1 0.0075 15.7 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 VDK88170.1 - 0.0089 15.9 0.1 0.58 10.0 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 VDK88170.1 - 0.015 14.9 0.0 0.02 14.5 0.0 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 VDK88170.1 - 0.051 13.3 0.1 0.076 12.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain MFS_2 PF13347.6 VDK88171.1 - 0.011 14.4 14.9 0.013 14.1 14.9 1.0 1 0 0 1 1 1 0 MFS/sugar transport protein adh_short_C2 PF13561.6 VDK88173.1 - 4.4e-69 232.6 0.4 6.5e-69 232.1 0.4 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 VDK88173.1 - 3.9e-54 183.1 0.1 6.2e-54 182.4 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 VDK88173.1 - 8.5e-15 55.1 0.1 1.5e-14 54.3 0.1 1.4 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 VDK88173.1 - 0.029 14.6 0.0 0.074 13.3 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF2540 PF10802.8 VDK88173.1 - 0.067 13.3 0.2 0.15 12.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) Pex14_N PF04695.13 VDK88174.1 - 9.4e-12 45.9 0.2 2.1e-09 38.3 0.0 2.3 1 1 1 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region Aldolase_II PF00596.21 VDK88177.1 - 4.3e-37 127.9 1.0 9.4e-30 103.9 0.0 3.5 3 1 0 3 3 3 2 Class II Aldolase and Adducin N-terminal domain IFT46_B_C PF12317.8 VDK88177.1 - 0.002 17.9 6.1 0.022 14.5 0.2 2.7 3 0 0 3 3 3 2 Intraflagellar transport complex B protein 46 C terminal BCOR PF15808.5 VDK88177.1 - 0.015 15.5 1.2 0.015 15.5 1.2 2.0 3 0 0 3 3 3 0 BCL-6 co-repressor, non-ankyrin-repeat region Scramblase PF03803.15 VDK88177.1 - 0.079 12.2 0.1 0.49 9.6 0.3 2.0 2 0 0 2 2 2 0 Scramblase MatP PF06303.12 VDK88177.1 - 0.22 12.1 4.7 4.5 7.9 0.1 3.0 3 0 0 3 3 3 0 MatP N-terminal domain Aldolase_II PF00596.21 VDK88178.1 - 2.6e-37 128.5 0.3 8.2e-30 104.1 0.0 3.3 2 1 1 3 3 3 3 Class II Aldolase and Adducin N-terminal domain BCOR PF15808.5 VDK88178.1 - 0.013 15.7 1.2 0.013 15.7 1.2 1.8 2 0 0 2 2 2 0 BCL-6 co-repressor, non-ankyrin-repeat region IFT46_B_C PF12317.8 VDK88178.1 - 0.02 14.6 0.2 0.02 14.6 0.2 1.8 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal Scramblase PF03803.15 VDK88178.1 - 0.067 12.5 0.2 0.45 9.8 0.3 2.0 2 0 0 2 2 2 0 Scramblase MatP PF06303.12 VDK88178.1 - 0.2 12.2 5.0 4 8.1 0.1 3.1 3 0 0 3 3 3 0 MatP N-terminal domain Profilin PF00235.19 VDK88181.1 - 9.3e-40 135.8 0.3 1e-39 135.7 0.3 1.0 1 0 0 1 1 1 1 Profilin Pkinase PF00069.25 VDK88183.1 - 3.7e-29 101.9 0.1 6.1e-29 101.2 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK88183.1 - 3.4e-16 59.3 0.1 4.4e-16 58.9 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 VDK88183.1 - 0.074 12.4 0.1 0.14 11.4 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BSD PF03909.17 VDK88194.1 - 2.2e-13 50.0 0.2 5.7e-13 48.7 0.2 1.7 1 0 0 1 1 1 1 BSD domain DUF3037 PF11236.8 VDK88194.1 - 0.17 12.3 0.5 0.57 10.6 0.1 2.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3037) LSM PF01423.22 VDK88195.1 - 6.5e-19 67.4 0.2 8.9e-19 67.0 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 VDK88195.1 - 0.0098 15.5 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 1 Hfq protein SRP68 PF16969.5 VDK88196.1 - 1.6e-113 380.7 3.5 2.1e-113 380.3 3.5 1.2 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 TPR_2 PF07719.17 VDK88196.1 - 0.00013 21.8 1.2 0.97 9.7 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF1398 PF07166.11 VDK88196.1 - 0.003 17.6 0.2 0.11 12.5 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1398) TPR_12 PF13424.6 VDK88196.1 - 0.03 14.6 1.0 4 7.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK88196.1 - 0.37 10.7 1.9 2.5 8.1 0.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat Ribosomal_L35Ae PF01247.18 VDK88197.1 - 3.1e-42 142.6 1.4 3.8e-42 142.4 1.4 1.1 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 VDK88197.1 - 0.015 15.5 0.0 1.5 9.1 0.0 2.2 2 0 0 2 2 2 0 RimM N-terminal domain Hexokinase_1 PF00349.21 VDK88202.1 - 2e-53 181.3 0.0 2.5e-53 180.9 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 VDK88202.1 - 4.3e-07 29.6 0.0 1.9e-06 27.5 0.1 1.9 2 0 0 2 2 2 1 Hexokinase MFS_1 PF07690.16 VDK88204.1 - 6.5e-31 107.5 26.6 6.5e-31 107.5 26.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF2781 PF10914.8 VDK88204.1 - 0.09 13.2 0.1 0.09 13.2 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2781) DUF63 PF01889.17 VDK88204.1 - 0.79 9.9 3.4 2.7 8.1 0.2 2.9 2 1 1 3 3 3 0 Membrane protein of unknown function DUF63 Myb_DNA-binding PF00249.31 VDK88207.1 - 2.7e-51 171.5 14.6 2.2e-13 50.1 0.0 6.6 6 0 0 6 6 6 6 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 VDK88207.1 - 3.3e-41 139.4 11.3 3.6e-09 36.7 0.1 6.3 3 1 3 6 6 6 5 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 VDK88207.1 - 0.00073 19.4 4.4 0.038 13.9 0.0 4.8 3 1 3 6 6 6 1 Myb DNA-binding like ARID PF01388.21 VDK88207.1 - 0.14 12.8 0.5 2.1 9.1 0.0 3.1 4 0 0 4 4 4 0 ARID/BRIGHT DNA binding domain Peptidase_C65 PF10275.9 VDK88208.1 - 1.5e-66 224.4 0.2 2.2e-66 223.8 0.2 1.2 1 0 0 1 1 1 1 Peptidase C65 Otubain Peptidase_C101 PF16218.5 VDK88208.1 - 0.094 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C101 F-box-like PF12937.7 VDK88208.1 - 0.11 12.4 0.4 0.11 12.4 0.4 2.2 2 0 0 2 2 2 0 F-box-like Peptidase_S8 PF00082.22 VDK88213.1 - 1.1e-14 54.4 1.0 1.5e-14 53.9 1.0 1.2 1 0 0 1 1 1 1 Subtilase family S8_pro-domain PF16470.5 VDK88213.1 - 3.4e-14 53.4 3.3 7.2e-14 52.3 3.3 1.5 1 0 0 1 1 1 1 Peptidase S8 pro-domain Peptidase_S8_N PF16361.5 VDK88213.1 - 0.15 12.6 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 N-terminal of Subtilase family Actin PF00022.19 VDK88215.1 - 1.5e-41 142.4 0.0 5.2e-41 140.6 0.0 1.7 1 1 0 1 1 1 1 Actin Shisa PF13908.6 VDK88216.1 - 0.00016 22.0 1.0 0.00022 21.5 1.0 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 VDK88216.1 - 0.0019 18.1 1.1 0.0019 18.1 1.1 2.4 1 1 1 3 3 3 1 TMEM154 protein family Chordopox_A13L PF05961.11 VDK88216.1 - 0.0026 18.0 0.9 0.0078 16.4 0.9 1.8 1 0 0 1 1 1 1 Chordopoxvirus A13L protein WBP-1 PF11669.8 VDK88216.1 - 0.0038 17.8 0.0 0.0069 17.0 0.0 1.4 1 0 0 1 1 1 1 WW domain-binding protein 1 DUF4834 PF16118.5 VDK88216.1 - 0.0064 17.4 0.3 0.013 16.5 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Comm PF15957.5 VDK88216.1 - 0.0089 16.4 0.1 0.019 15.3 0.1 1.6 1 1 0 1 1 1 1 Commissureless YajC PF02699.15 VDK88216.1 - 0.011 15.6 0.2 0.02 14.8 0.2 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit V_ATPase_I PF01496.19 VDK88216.1 - 0.014 13.4 0.2 0.018 13.0 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EphA2_TM PF14575.6 VDK88216.1 - 0.021 15.7 0.2 0.036 15.0 0.2 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF2681 PF10883.8 VDK88216.1 - 0.024 15.0 1.1 0.045 14.1 1.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) FAM163 PF15069.6 VDK88216.1 - 0.029 14.8 0.3 0.05 14.1 0.3 1.5 1 1 0 1 1 1 0 FAM163 family Pox_EPC_I2-L1 PF12575.8 VDK88216.1 - 0.031 14.5 2.0 0.37 11.1 0.3 2.4 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Orf78 PF06024.12 VDK88216.1 - 0.034 14.4 1.4 0.034 14.4 1.4 1.8 1 1 1 2 2 2 0 Orf78 (ac78) Tmemb_9 PF05434.11 VDK88216.1 - 0.035 14.0 0.4 0.055 13.4 0.4 1.3 1 0 0 1 1 1 0 TMEM9 DUF2207 PF09972.9 VDK88216.1 - 0.036 12.9 0.0 0.048 12.4 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mcm10 PF09332.11 VDK88216.1 - 0.036 13.5 4.1 0.048 13.1 4.1 1.1 1 0 0 1 1 1 0 Mcm10 replication factor SID-1_RNA_chan PF13965.6 VDK88216.1 - 0.036 12.5 0.6 0.045 12.2 0.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SCIMP PF15050.6 VDK88216.1 - 0.036 14.5 7.8 0.041 14.3 2.1 2.3 1 1 1 2 2 2 0 SCIMP protein Baculo_11_kDa PF06143.11 VDK88216.1 - 0.039 13.5 1.0 0.087 12.4 1.0 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family SIT PF15330.6 VDK88216.1 - 0.058 13.8 1.4 0.14 12.6 1.4 1.8 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT MLANA PF14991.6 VDK88216.1 - 0.062 13.6 2.0 0.11 12.8 1.9 1.6 1 1 0 1 1 1 0 Protein melan-A Ly49 PF08391.10 VDK88216.1 - 0.084 13.2 0.5 0.14 12.5 0.5 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Gag_p17 PF00540.18 VDK88216.1 - 0.096 12.7 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) ETRAMP PF09716.10 VDK88216.1 - 0.11 12.6 1.0 0.19 11.8 1.0 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) OATP PF03137.20 VDK88216.1 - 0.16 10.2 0.0 0.18 10.1 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Sigma_reg_N PF13800.6 VDK88216.1 - 0.16 12.3 1.5 0.18 12.1 0.2 1.7 2 0 0 2 2 1 0 Sigma factor regulator N-terminal OAD_gamma PF04277.13 VDK88216.1 - 0.19 12.4 7.6 0.67 10.6 6.0 2.7 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Sec61_beta PF03911.16 VDK88216.1 - 0.38 10.8 4.9 0.79 9.8 4.9 1.5 1 0 0 1 1 1 0 Sec61beta family ODV-E18 PF10717.9 VDK88216.1 - 2.3 8.2 5.8 1.4 8.8 3.6 1.7 2 0 0 2 2 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF5383 PF17355.2 VDK88216.1 - 2.9 8.3 10.5 0.16 12.4 1.9 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5383) TMEM171 PF15471.6 VDK88216.1 - 3.2 6.6 5.7 2.4 7.0 0.0 2.0 1 1 1 2 2 2 0 Transmembrane protein family 171 TRIQK PF15168.6 VDK88216.1 - 8.7 6.3 11.0 5.4 7.0 2.2 2.2 1 1 1 2 2 2 0 Triple QxxK/R motif-containing protein family PDZ PF00595.24 VDK88217.1 - 4.9e-60 199.9 5.0 8.1e-20 71.0 0.1 3.5 3 0 0 3 3 3 3 PDZ domain Guanylate_kin PF00625.21 VDK88217.1 - 7.8e-51 172.3 0.0 1.9e-50 171.1 0.0 1.7 1 0 0 1 1 1 1 Guanylate kinase PDZ_6 PF17820.1 VDK88217.1 - 2.3e-23 81.8 1.3 9.2e-10 38.2 0.1 3.6 3 0 0 3 3 3 3 PDZ domain L27_1 PF09058.10 VDK88217.1 - 5.4e-23 80.7 0.6 1.2e-22 79.6 0.6 1.7 1 0 0 1 1 1 1 L27_1 PDZ_2 PF13180.6 VDK88217.1 - 5.4e-14 52.3 1.3 0.004 17.5 0.0 3.7 3 0 0 3 3 3 3 PDZ domain SH3_1 PF00018.28 VDK88217.1 - 1.1e-06 28.1 0.0 2.7e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK88217.1 - 4.5e-06 26.2 0.0 1.7e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 VDK88217.1 - 0.02 14.7 0.0 0.057 13.3 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain Tricorn_PDZ PF14685.6 VDK88217.1 - 0.03 14.3 0.6 2.4 8.2 0.0 3.2 3 0 0 3 3 3 0 Tricorn protease PDZ domain Biotin_lipoyl_2 PF13533.6 VDK88217.1 - 0.083 12.7 0.2 1.3 8.9 0.1 2.7 2 1 1 3 3 3 0 Biotin-lipoyl like Vezatin PF12632.7 VDK88217.1 - 0.1 11.9 0.4 0.18 11.1 0.4 1.3 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes DUF4728 PF15860.5 VDK88220.1 - 0.023 15.4 16.1 0.036 14.7 16.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4728) Mtp PF03821.16 VDK88220.1 - 0.65 9.6 10.4 0.32 10.6 8.3 1.4 1 1 0 1 1 1 0 Golgi 4-transmembrane spanning transporter Metallophos PF00149.28 VDK88221.1 - 2.9e-30 106.3 0.0 3.7e-30 105.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 VDK88221.1 - 0.15 12.3 0.0 0.46 10.7 0.0 1.7 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain HTH_51 PF18558.1 VDK88221.1 - 0.17 11.7 0.0 26 4.8 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain TM2 PF05154.16 VDK88222.1 - 4e-12 46.3 8.1 6e-12 45.7 8.1 1.2 1 0 0 1 1 1 1 TM2 domain zf-Tim10_DDP PF02953.15 VDK88223.1 - 1.3e-20 72.8 2.2 1.3e-20 72.8 2.2 2.1 2 0 0 2 2 2 1 Tim10/DDP family zinc finger UPF0449 PF15136.6 VDK88223.1 - 0.028 14.9 3.9 0.034 14.6 3.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 Ribosomal_S2 PF00318.20 VDK88223.1 - 0.056 12.7 0.8 0.064 12.5 0.8 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 ERK-JNK_inhib PF15002.6 VDK88226.1 - 0.041 13.6 0.1 0.061 13.0 0.1 1.1 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor Pkinase_Tyr PF07714.17 VDK88227.1 - 5e-15 55.5 0.0 9e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK88227.1 - 8.5e-14 51.5 0.1 1.7e-13 50.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain ANF_receptor PF01094.28 VDK88227.1 - 6.7e-11 41.9 1.6 3.1e-10 39.7 1.6 1.9 1 1 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 VDK88227.1 - 0.094 12.4 0.1 2.4 7.7 0.1 2.1 2 0 0 2 2 2 0 Periplasmic binding protein HECT PF00632.25 VDK88232.1 - 4.3e-77 259.6 0.1 9.5e-77 258.5 0.0 1.6 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) WWE PF02825.20 VDK88232.1 - 6.6e-16 58.7 1.3 1.8e-15 57.3 0.8 2.1 2 0 0 2 2 2 1 WWE domain HMG_box PF00505.19 VDK88234.1 - 1.3e-13 51.2 1.7 2.6e-13 50.2 1.7 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDK88234.1 - 3.6e-10 40.3 1.8 7.6e-10 39.3 1.8 1.5 1 0 0 1 1 1 1 HMG-box domain FOXP-CC PF16159.5 VDK88234.1 - 0.0089 16.6 1.0 1.1 9.9 0.1 2.8 2 0 0 2 2 2 1 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 VDK88234.1 - 0.013 15.6 0.9 0.024 14.8 0.9 1.4 1 0 0 1 1 1 0 Aberrant zinc-finger zf-C2H2 PF00096.26 VDK88234.1 - 0.023 15.2 3.3 0.52 10.9 0.2 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type CHDNT PF08073.12 VDK88234.1 - 0.037 14.0 0.1 0.17 11.9 0.0 2.1 2 0 0 2 2 2 0 CHDNT (NUC034) domain zf-C2H2_4 PF13894.6 VDK88234.1 - 0.09 13.7 2.2 11 7.1 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Zap1_zf2 PF18217.1 VDK88234.1 - 2.3 8.3 6.5 0.25 11.4 0.9 2.1 2 0 0 2 2 2 0 Zap1 zinc finger 2 MIF PF01187.18 VDK88235.1 - 5.3e-49 165.3 0.0 5.8e-49 165.2 0.0 1.0 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) PI3_PI4_kinase PF00454.27 VDK88238.1 - 3.9e-31 108.8 0.0 6e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase XRCC4 PF06632.12 VDK88238.1 - 0.091 11.6 1.9 0.13 11.0 1.9 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Zein PF01559.16 VDK88243.1 - 0.2 11.2 0.0 0.42 10.2 0.0 1.5 2 0 0 2 2 2 0 Zein seed storage protein RGS PF00615.19 VDK88243.1 - 0.64 10.3 4.8 8 6.8 0.3 2.5 1 1 1 2 2 2 0 Regulator of G protein signaling domain KAP PF05804.12 VDK88244.1 - 1.5e-162 542.4 27.3 3.2e-162 541.3 27.3 1.5 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) Cation_efflux PF01545.21 VDK88245.1 - 6.2e-16 58.7 21.9 1.7e-15 57.3 21.9 1.8 1 1 0 1 1 1 1 Cation efflux family HCV_NS4a PF01006.20 VDK88245.1 - 0.16 11.7 1.5 11 5.8 0.1 3.0 2 1 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a COQ7 PF03232.13 VDK88247.1 - 7.5e-63 211.4 0.1 8.6e-63 211.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 VDK88247.1 - 0.009 16.4 0.1 0.029 14.8 0.1 1.7 1 1 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.6 VDK88247.1 - 0.068 13.4 0.9 4.6 7.4 0.1 2.2 1 1 1 2 2 2 0 Ferritin-like domain MMS1_N PF10433.9 VDK88247.1 - 0.078 11.6 0.0 0.096 11.3 0.0 1.1 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Tubulin_C PF03953.17 VDK88249.1 - 0.00052 20.2 0.0 0.0008 19.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain C2 PF00168.30 VDK88250.1 - 2.4e-06 27.7 0.0 5.8e-06 26.5 0.0 1.6 1 1 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 VDK88250.1 - 0.028 14.0 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 CEP76 C2 domain Gal-bind_lectin PF00337.22 VDK88252.1 - 7.5e-48 161.5 0.0 4.4e-23 81.3 0.0 2.1 2 0 0 2 2 2 2 Galactoside-binding lectin COesterase PF00135.28 VDK88254.1 - 1e-145 486.5 0.1 1.3e-145 486.2 0.1 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 VDK88254.1 - 9.9e-10 38.6 0.1 3.2e-09 36.9 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold RNA_pol_Rpb1_3 PF04983.18 VDK88254.1 - 0.18 11.8 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 3 NCBP3 PF10309.9 VDK88258.1 - 6.5e-05 22.7 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Ribonuc_red_lgC PF02867.15 VDK88260.1 - 1.5e-191 637.5 0.0 1.8e-191 637.2 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 VDK88260.1 - 2.5e-23 81.9 0.8 5.4e-23 80.8 0.1 2.0 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 VDK88260.1 - 5.7e-18 65.3 0.2 1.9e-17 63.6 0.2 2.0 1 0 0 1 1 1 1 ATP cone domain ArAE_1_C PF11728.8 VDK88260.1 - 0.069 13.1 0.4 0.14 12.2 0.4 1.4 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain OPA3 PF07047.12 VDK88261.1 - 3.3e-22 78.6 0.6 4.3e-22 78.2 0.6 1.1 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) Chordopox_A13L PF05961.11 VDK88261.1 - 0.015 15.5 0.2 0.029 14.6 0.2 1.5 1 0 0 1 1 1 0 Chordopoxvirus A13L protein RNA_pol_L PF01193.24 VDK88262.1 - 6.1e-22 76.8 0.0 5.1e-21 73.9 0.0 2.4 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 VDK88262.1 - 9.1e-22 77.5 0.0 3.5e-21 75.7 0.0 2.0 2 1 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain Arf PF00025.21 VDK88269.1 - 2.2e-30 105.4 0.1 2.7e-30 105.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 VDK88269.1 - 2.2e-11 43.5 1.3 2.8e-05 23.4 0.1 2.0 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 VDK88269.1 - 2.1e-07 30.5 0.0 2.6e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 VDK88269.1 - 1.2e-06 28.8 0.0 1.5e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 VDK88269.1 - 1.3e-06 28.5 0.0 1.7e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK88269.1 - 8.2e-06 25.3 0.0 9.4e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 VDK88269.1 - 6.8e-05 22.5 0.0 8.2e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Ras family AAA_29 PF13555.6 VDK88269.1 - 0.035 13.9 0.1 0.078 12.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 VDK88269.1 - 0.041 14.4 0.0 0.047 14.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain FeoB_N PF02421.18 VDK88269.1 - 0.045 13.3 0.2 0.083 12.4 0.2 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 VDK88269.1 - 0.12 12.5 0.1 5.2 7.1 0.0 2.1 1 1 0 2 2 2 0 Dynamin family AAA_22 PF13401.6 VDK88269.1 - 0.13 12.5 0.1 0.4 11.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF2012 PF09430.10 VDK88271.1 - 2e-30 105.4 0.0 2.8e-30 104.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 VDK88271.1 - 0.044 14.1 0.0 0.074 13.3 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 VDK88271.1 - 0.062 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 CarboxypepD_reg-like domain SOP4 PF17081.5 VDK88271.1 - 0.096 12.2 0.2 1 8.8 0.1 2.1 2 0 0 2 2 2 0 Suppressor of PMA 1-7 protein JmjC PF02373.22 VDK88271.1 - 0.16 12.4 0.0 0.29 11.6 0.0 1.3 1 0 0 1 1 1 0 JmjC domain, hydroxylase ARPC4 PF05856.12 VDK88272.1 - 1.2e-79 265.7 3.8 1.4e-79 265.6 3.8 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Dala_Dala_lig_C PF07478.13 VDK88272.1 - 0.089 12.3 0.2 7.4 6.0 0.0 2.2 1 1 1 2 2 2 0 D-ala D-ala ligase C-terminus bZIP_1 PF00170.21 VDK88282.1 - 4e-12 46.1 14.3 1.2e-11 44.5 14.3 1.9 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 VDK88282.1 - 9.4e-07 28.8 16.2 3.1e-06 27.2 16.2 2.0 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 VDK88282.1 - 2.1e-06 28.2 8.8 4.4e-06 27.1 8.8 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 VDK88282.1 - 0.012 16.0 2.3 0.012 16.0 2.3 3.0 3 0 0 3 3 3 0 Cell division protein ZapB UPF0449 PF15136.6 VDK88282.1 - 0.46 11.0 4.4 0.86 10.1 3.9 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF724 PF05266.14 VDK88282.1 - 9.2 6.0 10.5 57 3.5 10.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) eRF1_1 PF03463.15 VDK88283.1 - 4.3e-46 156.1 0.1 6.9e-46 155.4 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 VDK88283.1 - 2.2e-29 102.5 0.2 3.9e-29 101.7 0.2 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 VDK88283.1 - 9.9e-24 84.0 0.0 2.5e-23 82.7 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 Cue1_U7BR PF18499.1 VDK88283.1 - 0.11 12.5 0.3 4.7 7.3 0.0 3.2 3 0 0 3 3 3 0 Ubc7p-binding region of Cue1 TUDOR PF00567.24 VDK88285.1 - 3.4e-18 65.8 0.0 1.1e-07 32.0 0.0 2.4 2 0 0 2 2 2 2 Tudor domain Glycos_transf_2 PF00535.26 VDK88286.1 - 4.8e-08 33.0 0.5 1.8e-07 31.2 0.2 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 2 CDP-OH_P_transf PF01066.21 VDK88292.1 - 5.4e-16 59.1 0.3 5.4e-16 59.1 0.3 3.4 3 2 0 3 3 3 1 CDP-alcohol phosphatidyltransferase Acyltransferase PF01553.21 VDK88295.1 - 2.9e-22 78.7 0.0 4.7e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 VDK88295.1 - 4.1e-12 46.0 0.1 7.7e-12 45.1 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus UCH PF00443.29 VDK88296.1 - 2.1e-40 138.9 0.3 2.1e-40 138.9 0.3 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 VDK88296.1 - 6.7e-14 52.0 0.3 3e-13 49.9 0.5 2.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 VDK88296.1 - 0.022 14.5 1.0 0.27 11.0 0.7 2.4 2 0 0 2 2 2 0 Variant UBP zinc finger BTB PF00651.31 VDK88297.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain zf-C3HC4_4 PF15227.6 VDK88298.1 - 6.5e-10 39.0 13.4 6.5e-10 39.0 13.4 2.5 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 VDK88298.1 - 1.4e-09 37.7 12.6 1.4e-09 37.7 12.6 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK88298.1 - 1.6e-08 34.4 5.0 1.6e-08 34.4 5.0 2.9 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 VDK88298.1 - 2.2e-08 34.3 10.8 2.2e-08 34.3 10.8 2.5 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK88298.1 - 1e-07 31.7 11.3 1e-07 31.7 11.3 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK88298.1 - 3.7e-07 29.9 9.3 3.7e-07 29.9 9.3 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK88298.1 - 7.4e-07 29.0 11.2 7.4e-07 29.0 11.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK88298.1 - 0.00025 20.8 8.5 0.00025 20.8 8.5 2.5 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 VDK88298.1 - 0.0056 16.9 9.2 0.0056 16.9 9.2 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 VDK88298.1 - 0.01 15.9 5.1 0.01 15.9 5.1 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF3583 PF12126.8 VDK88298.1 - 0.041 13.4 0.0 0.049 13.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) Angiomotin_C PF12240.8 VDK88298.1 - 0.18 11.4 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Angiomotin C terminal zf-H2C2_2 PF13465.6 VDK88298.1 - 0.21 12.1 0.4 0.21 12.1 0.4 4.1 4 2 1 5 5 4 0 Zinc-finger double domain zf-RING_4 PF14570.6 VDK88298.1 - 0.63 9.9 25.1 0.049 13.4 12.3 2.9 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 VDK88298.1 - 0.84 9.5 13.4 0.34 10.8 5.7 2.6 2 2 0 2 2 2 0 zf-RING of BARD1-type protein Baculo_IE-1 PF05290.11 VDK88298.1 - 1.3 9.0 13.5 0.051 13.5 6.5 2.1 1 1 1 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-C2H2_4 PF13894.6 VDK88298.1 - 1.7 9.7 0.2 1.7 9.7 0.2 4.7 4 1 1 5 5 5 0 C2H2-type zinc finger Rep_fac-A_C PF08646.10 VDK88298.1 - 1.8 8.3 17.0 0.079 12.7 3.9 2.2 1 1 1 2 2 2 0 Replication factor-A C terminal domain zf-C3HC4_4 PF15227.6 VDK88299.1 - 6.5e-10 39.0 13.4 6.5e-10 39.0 13.4 2.5 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 VDK88299.1 - 1.4e-09 37.7 12.6 1.4e-09 37.7 12.6 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 VDK88299.1 - 1.6e-08 34.4 5.0 1.6e-08 34.4 5.0 2.9 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 VDK88299.1 - 2.2e-08 34.3 10.8 2.2e-08 34.3 10.8 2.5 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK88299.1 - 1e-07 31.7 11.3 1e-07 31.7 11.3 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDK88299.1 - 3.7e-07 29.9 9.3 3.7e-07 29.9 9.3 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK88299.1 - 7.4e-07 29.0 11.2 7.4e-07 29.0 11.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 VDK88299.1 - 0.00025 20.8 8.5 0.00025 20.8 8.5 2.5 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 VDK88299.1 - 0.0056 16.9 9.2 0.0056 16.9 9.2 2.5 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 VDK88299.1 - 0.01 15.9 5.1 0.01 15.9 5.1 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF3583 PF12126.8 VDK88299.1 - 0.041 13.4 0.0 0.049 13.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) Angiomotin_C PF12240.8 VDK88299.1 - 0.18 11.4 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Angiomotin C terminal zf-H2C2_2 PF13465.6 VDK88299.1 - 0.21 12.1 0.4 0.21 12.1 0.4 4.1 4 2 1 5 5 4 0 Zinc-finger double domain zf-RING_4 PF14570.6 VDK88299.1 - 0.63 9.9 25.1 0.049 13.4 12.3 2.9 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 VDK88299.1 - 0.84 9.5 13.4 0.34 10.8 5.7 2.6 2 2 0 2 2 2 0 zf-RING of BARD1-type protein Baculo_IE-1 PF05290.11 VDK88299.1 - 1.3 9.0 13.5 0.051 13.5 6.5 2.1 1 1 1 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-C2H2_4 PF13894.6 VDK88299.1 - 1.7 9.7 0.2 1.7 9.7 0.2 4.7 4 1 1 5 5 5 0 C2H2-type zinc finger Rep_fac-A_C PF08646.10 VDK88299.1 - 1.8 8.3 17.0 0.079 12.7 3.9 2.2 1 1 1 2 2 2 0 Replication factor-A C terminal domain DUF1509 PF07420.11 VDK88300.1 - 0.038 12.9 12.4 0.054 12.5 12.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1509) Coiled-coil_56 PF09813.9 VDK88300.1 - 0.041 13.9 0.1 0.77 9.8 0.0 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 AdHead_fibreRBD PF16812.5 VDK88300.1 - 0.34 10.7 6.2 0.55 10.0 6.2 1.3 1 0 0 1 1 1 0 C-terminal head domain of the fowl adenovirus type 1 long fibre YchF-GTPase_C PF06071.13 VDK88302.1 - 8e-41 138.1 0.3 2.2e-40 136.7 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 VDK88302.1 - 6.9e-22 77.7 0.0 2.4e-21 75.9 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 VDK88302.1 - 1.4e-07 31.2 0.0 3.8e-07 29.7 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B TGS PF02824.21 VDK88302.1 - 0.0031 17.5 0.0 0.0069 16.4 0.0 1.6 1 0 0 1 1 1 1 TGS domain MeaB PF03308.16 VDK88302.1 - 0.02 13.9 0.0 0.045 12.7 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 VDK88302.1 - 0.027 14.7 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase LSM PF01423.22 VDK88303.1 - 9.6e-18 63.7 0.1 1.2e-17 63.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain Proteasome PF00227.26 VDK88305.1 - 1.9e-59 200.4 0.0 2.7e-59 199.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 VDK88305.1 - 1.9e-14 53.0 0.2 3.3e-14 52.2 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Peptidase_A17 PF05380.13 VDK88310.1 - 2.8e-14 53.4 0.0 4.4e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Pao retrotransposon peptidase BAR_3 PF16746.5 VDK88313.1 - 1.7e-65 221.1 14.4 2.4e-65 220.6 14.4 1.2 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 VDK88313.1 - 7.4e-07 29.6 2.8 1.2e-06 28.9 0.1 2.6 2 1 1 3 3 3 1 PH domain BAR PF03114.18 VDK88313.1 - 4.2e-05 23.3 5.9 4.2e-05 23.3 5.9 2.2 1 1 1 2 2 2 1 BAR domain Vps5 PF09325.10 VDK88313.1 - 0.0021 17.7 7.2 0.0026 17.3 2.4 2.6 2 1 0 2 2 2 1 Vps5 C terminal like HMG_box_5 PF14887.6 VDK88313.1 - 0.23 11.4 1.5 0.64 10.0 0.1 2.4 2 1 1 3 3 3 0 HMG (high mobility group) box 5 PH_9 PF15410.6 VDK88313.1 - 0.26 11.7 6.0 1.5 9.2 0.1 2.9 2 1 1 3 3 3 0 Pleckstrin homology domain Arfaptin PF06456.13 VDK88313.1 - 0.61 9.6 10.6 0.16 11.5 3.5 2.5 1 1 0 2 2 2 0 Arfaptin-like domain RhoGAP PF00620.27 VDK88314.1 - 4.2e-41 140.3 0.0 6.4e-41 139.7 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain ANAPC15 PF15243.6 VDK88316.1 - 3.5 8.1 7.9 6.2 7.3 7.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Strumpellin PF10266.9 VDK88317.1 - 5.3e-209 696.7 11.8 6.2e-209 696.4 11.8 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin TMF_DNA_bd PF12329.8 VDK88317.1 - 3 7.9 5.7 1.4 9.0 2.2 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding ATP-synt_ab PF00006.25 VDK88318.1 - 5.3e-68 228.8 0.0 7.4e-68 228.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 VDK88318.1 - 9.7e-14 51.6 0.2 1.9e-13 50.7 0.2 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain RRM_1 PF00076.22 VDK88319.1 - 1.6e-24 85.5 0.1 7.8e-08 32.0 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1727 PF08353.10 VDK88321.1 - 0.0013 18.6 0.1 0.0026 17.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1727) YfhD PF14151.6 VDK88321.1 - 0.08 13.1 0.3 0.15 12.2 0.3 1.5 1 0 0 1 1 1 0 YfhD-like protein Nop14 PF04147.12 VDK88322.1 - 0.35 9.0 17.9 0.33 9.1 17.9 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 VDK88322.1 - 0.73 9.1 26.0 0.87 8.8 26.0 1.1 1 0 0 1 1 1 0 NOA36 protein RRN3 PF05327.11 VDK88322.1 - 1.2 7.6 9.4 1.2 7.6 9.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 VDK88322.1 - 5.7 6.2 20.0 5.9 6.1 20.0 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 VDK88322.1 - 9.1 5.6 19.1 9.6 5.5 19.1 1.1 1 0 0 1 1 1 0 SDA1 Rhomboid PF01694.22 VDK88325.1 - 4.1e-26 91.8 6.6 4.1e-26 91.8 6.6 1.7 2 0 0 2 2 2 1 Rhomboid family COG6 PF06419.11 VDK88326.1 - 9.1e-152 506.5 18.8 1.2e-151 506.1 18.8 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Sec34 PF04136.15 VDK88326.1 - 5.9e-05 23.0 4.4 0.00018 21.4 2.9 2.7 1 1 0 1 1 1 1 Sec34-like family ATG16 PF08614.11 VDK88326.1 - 0.017 15.3 8.7 0.017 15.3 6.2 2.3 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF5082 PF16888.5 VDK88326.1 - 0.026 14.8 3.8 0.077 13.3 3.4 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) GCSF PF16647.5 VDK88326.1 - 0.039 13.8 0.2 0.12 12.2 0.2 1.8 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor Acetyltransf_11 PF13720.6 VDK88326.1 - 0.091 13.2 0.3 11 6.6 0.1 3.2 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Jnk-SapK_ap_N PF09744.9 VDK88326.1 - 0.45 10.7 10.0 0.3 11.3 4.1 2.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FAS_N PF17828.1 VDK88326.1 - 0.5 10.4 3.6 26 4.8 0.9 3.4 3 0 0 3 3 3 0 N-terminal domain in fatty acid synthase subunit beta YabA PF06156.13 VDK88326.1 - 0.69 10.6 5.4 0.93 10.2 2.4 2.7 1 1 1 2 2 2 0 Initiation control protein YabA NleF_casp_inhib PF16809.5 VDK88326.1 - 6 6.8 12.0 0.2 11.6 4.1 2.5 3 0 0 3 3 3 0 NleF caspase inhibitor GAT PF03127.14 VDK88326.1 - 6.2 7.2 7.5 24 5.4 0.8 4.3 3 1 0 3 3 3 0 GAT domain GDPD PF03009.17 VDK88327.1 - 3e-46 158.3 0.0 3.7e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Patched PF02460.18 VDK88332.1 - 1.2e-96 324.7 14.5 2.1e-77 261.0 5.5 3.0 2 1 1 3 3 3 3 Patched family Sterol-sensing PF12349.8 VDK88332.1 - 7.4e-38 129.8 6.1 7.4e-38 129.8 6.1 2.7 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK88332.1 - 0.00022 20.3 7.3 0.00069 18.6 3.2 2.5 2 1 0 2 2 2 2 MMPL family Col_cuticle_N PF01484.17 VDK88332.1 - 0.62 10.2 0.0 0.62 10.2 0.0 3.4 4 0 0 4 4 4 0 Nematode cuticle collagen N-terminal domain COG4 PF08318.12 VDK88334.1 - 8.1e-77 258.5 5.1 1.3e-76 257.9 5.1 1.3 1 0 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.13 VDK88334.1 - 1.3e-05 24.3 0.2 4.6e-05 22.5 0.0 1.9 1 1 0 2 2 2 1 RINT-1 / TIP-1 family NADH_B2 PF14813.6 VDK88335.1 - 2.1e-16 59.5 0.1 2.1e-16 59.5 0.1 1.6 2 0 0 2 2 2 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Ig_3 PF13927.6 VDK88337.1 - 3.9e-47 158.8 1.9 1.9e-11 44.4 0.0 5.5 5 0 0 5 5 5 5 Immunoglobulin domain I-set PF07679.16 VDK88337.1 - 8e-41 138.0 3.7 1.4e-11 44.3 0.0 6.1 5 2 0 5 5 5 4 Immunoglobulin I-set domain ig PF00047.25 VDK88337.1 - 8e-31 106.1 0.1 2.5e-07 30.8 0.0 5.5 5 0 0 5 5 5 4 Immunoglobulin domain Ig_2 PF13895.6 VDK88337.1 - 3.4e-26 91.4 1.0 3.7e-07 30.4 0.1 5.8 5 0 0 5 5 5 4 Immunoglobulin domain V-set PF07686.17 VDK88337.1 - 8.7e-16 58.1 2.9 5.9e-05 23.2 0.0 6.9 5 3 1 6 6 6 3 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDK88337.1 - 1.6e-12 47.3 0.6 0.00011 22.2 0.0 6.8 4 2 2 6 6 6 1 CD80-like C2-set immunoglobulin domain C1-set PF07654.15 VDK88337.1 - 9e-09 35.6 0.4 0.077 13.4 0.0 5.0 5 1 0 5 5 5 2 Immunoglobulin C1-set domain Ig_5 PF16681.5 VDK88337.1 - 2.7e-06 27.7 0.0 3.5 8.1 0.0 4.9 4 1 0 4 4 4 3 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 VDK88337.1 - 0.0027 17.7 0.0 14 5.8 0.0 4.1 3 1 1 4 4 4 1 Izumo-like Immunoglobulin domain Ig_C17orf99 PF17736.1 VDK88337.1 - 0.02 14.9 0.0 29 4.8 0.0 3.9 4 0 0 4 4 4 0 C17orf99 Ig domain tRNA-synt_2d PF01409.20 VDK88342.1 - 1.2e-89 300.0 0.2 1.6e-89 299.6 0.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD1 PF18552.1 VDK88342.1 - 6.4e-21 73.9 1.1 9.2e-21 73.4 0.4 1.7 2 0 0 2 2 2 1 PheRS DNA binding domain 1 PheRS_DBD3 PF18553.1 VDK88342.1 - 3.9e-17 62.3 0.3 1.1e-16 60.8 0.0 2.0 2 0 0 2 2 2 1 PheRS DNA binding domain 3 PheRS_DBD2 PF18554.1 VDK88342.1 - 2.1e-10 40.4 5.7 6e-10 38.9 5.7 1.9 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA_synthFbeta PF17759.1 VDK88342.1 - 1e-07 31.6 0.0 7.1e-05 22.3 0.1 2.6 3 0 0 3 3 3 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 VDK88342.1 - 5.2e-05 22.5 2.6 0.0012 18.1 0.1 2.9 4 0 0 4 4 4 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 VDK88342.1 - 0.012 15.5 0.1 0.041 13.8 0.0 1.9 2 1 1 3 3 3 0 tRNA synthetase class II core domain (G, H, P, S and T) Rhomboid PF01694.22 VDK88343.1 - 5.8e-21 75.1 13.7 5.8e-21 75.1 13.7 1.7 1 1 1 2 2 2 1 Rhomboid family RAM PF15320.6 VDK88344.1 - 8.2e-08 32.8 2.8 1.3e-07 32.1 2.8 1.3 1 0 0 1 1 1 1 mRNA cap methylation, RNMT-activating mini protein Med4 PF10018.9 VDK88345.1 - 2.1e-27 96.1 0.2 3.4e-27 95.4 0.2 1.4 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 Helo_like_N PF17111.5 VDK88345.1 - 0.0024 17.3 0.8 0.0074 15.7 0.4 1.9 1 1 1 2 2 2 1 Fungal N-terminal domain of STAND proteins ADIP PF11559.8 VDK88345.1 - 0.0058 16.7 2.8 0.012 15.6 2.8 1.5 1 1 0 1 1 1 1 Afadin- and alpha -actinin-Binding RPW8 PF05659.11 VDK88345.1 - 0.02 14.6 2.7 0.46 10.2 0.8 2.3 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Med2 PF11214.8 VDK88345.1 - 0.024 14.8 2.1 0.041 14.0 2.1 1.4 1 1 0 1 1 1 0 Mediator complex subunit 2 HMMR_N PF15905.5 VDK88345.1 - 0.041 13.4 4.0 0.056 12.9 4.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal TBK1_CCD1 PF18394.1 VDK88345.1 - 0.042 13.4 2.8 0.057 13.0 2.8 1.1 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 OmpH PF03938.14 VDK88345.1 - 0.057 13.8 2.4 0.11 12.8 2.4 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) E2R135 PF11570.8 VDK88345.1 - 0.065 13.5 0.5 0.12 12.6 0.5 1.4 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 OrfB_IS605 PF01385.19 VDK88345.1 - 0.082 13.1 0.2 0.15 12.3 0.2 1.4 1 0 0 1 1 1 0 Probable transposase Lebercilin PF15619.6 VDK88345.1 - 0.15 11.7 9.6 0.067 12.9 6.6 1.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4778 PF16008.5 VDK88345.1 - 0.39 10.7 2.2 0.26 11.3 0.7 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) Ig_3 PF13927.6 VDK88349.1 - 0.0011 19.5 0.0 0.0036 17.9 0.0 1.9 2 0 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 VDK88349.1 - 0.002 18.5 0.0 0.018 15.4 0.0 2.2 1 1 1 2 2 2 1 Immunoglobulin domain C2-set_2 PF08205.12 VDK88349.1 - 0.012 15.7 0.4 1.3 9.2 0.0 3.3 3 1 1 4 4 4 0 CD80-like C2-set immunoglobulin domain Ntox4 PF15541.6 VDK88349.1 - 0.028 14.8 0.0 0.097 13.0 0.0 1.9 2 1 0 2 2 2 0 Bacterial toxin 4 Patched PF02460.18 VDK88355.1 - 1.2e-96 324.7 14.5 2.1e-77 261.0 5.5 3.0 2 1 1 3 3 3 3 Patched family Sterol-sensing PF12349.8 VDK88355.1 - 7.4e-38 129.8 6.1 7.4e-38 129.8 6.1 2.7 2 1 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK88355.1 - 0.00022 20.3 7.3 0.00069 18.6 3.2 2.5 2 1 0 2 2 2 2 MMPL family Col_cuticle_N PF01484.17 VDK88355.1 - 0.62 10.2 0.0 0.62 10.2 0.0 3.4 4 0 0 4 4 4 0 Nematode cuticle collagen N-terminal domain COG4 PF08318.12 VDK88357.1 - 8.1e-77 258.5 5.1 1.3e-76 257.9 5.1 1.3 1 0 0 1 1 1 1 COG4 transport protein RINT1_TIP1 PF04437.13 VDK88357.1 - 1.3e-05 24.3 0.2 4.6e-05 22.5 0.0 1.9 1 1 0 2 2 2 1 RINT-1 / TIP-1 family NADH_B2 PF14813.6 VDK88358.1 - 2.1e-16 59.5 0.1 2.1e-16 59.5 0.1 1.6 2 0 0 2 2 2 1 NADH dehydrogenase 1 beta subcomplex subunit 2 TUDOR PF00567.24 VDK88361.1 - 1.2e-21 77.0 0.0 1.8e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Tudor domain KH_1 PF00013.29 VDK88361.1 - 5.6e-10 38.9 0.4 9.6e-10 38.2 0.4 1.4 1 0 0 1 1 1 1 KH domain Agenet PF05641.12 VDK88361.1 - 0.055 13.9 0.3 0.22 12.0 0.1 2.1 2 0 0 2 2 2 0 Agenet domain Septum_form PF13845.6 VDK88362.1 - 0.031 13.8 0.2 0.041 13.4 0.2 1.2 1 0 0 1 1 1 0 Septum formation DUF3458 PF11940.8 VDK88362.1 - 0.05 14.1 2.0 0.075 13.5 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3458) Ig-like fold Senescence_reg PF04520.13 VDK88362.1 - 0.097 13.5 0.5 0.12 13.2 0.5 1.2 1 0 0 1 1 1 0 Senescence regulator RINGv PF12906.7 VDK88365.1 - 5.7e-13 48.8 8.6 5.7e-13 48.8 8.6 2.0 2 0 0 2 2 2 1 RING-variant domain SUR7 PF06687.12 VDK88365.1 - 0.0012 18.5 5.4 0.0016 18.1 5.4 1.3 1 0 0 1 1 1 1 SUR7/PalI family DUF3169 PF11368.8 VDK88365.1 - 0.0062 16.1 1.8 0.0096 15.5 1.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) HTH_51 PF18558.1 VDK88365.1 - 0.15 12.0 0.1 0.43 10.5 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Virul_fac_BrkB PF03631.15 VDK88365.1 - 0.27 10.8 2.9 0.63 9.6 2.8 1.5 1 1 0 1 1 1 0 Virulence factor BrkB Sigma_reg_N PF13800.6 VDK88365.1 - 1.5 9.2 7.7 3.7 7.9 1.0 2.3 1 1 1 2 2 2 0 Sigma factor regulator N-terminal CH PF00307.31 VDK88369.1 - 3e-23 82.1 1.6 1.7e-10 41.0 0.3 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Amidase PF01425.21 VDK88370.1 - 7.6e-09 35.0 0.0 8.1e-09 34.9 0.0 1.0 1 0 0 1 1 1 1 Amidase NODP PF07684.12 VDK88370.1 - 0.076 13.2 0.3 0.74 10.0 0.0 2.1 2 0 0 2 2 2 0 NOTCH protein Amidase PF01425.21 VDK88372.1 - 5.5e-27 94.8 0.0 6.3e-27 94.6 0.0 1.0 1 0 0 1 1 1 1 Amidase EMP70 PF02990.16 VDK88373.1 - 2.7e-157 524.6 17.4 3.3e-157 524.3 17.4 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Thioredoxin PF00085.20 VDK88375.1 - 4.1e-17 62.1 0.2 9.3e-17 60.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin Zip PF02535.22 VDK88375.1 - 0.0072 15.6 0.1 0.01 15.1 0.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter OST3_OST6 PF04756.13 VDK88375.1 - 0.01 15.2 0.3 0.027 13.8 0.1 1.9 1 1 1 2 2 2 0 OST3 / OST6 family, transporter family DUF4834 PF16118.5 VDK88375.1 - 0.015 16.2 0.4 0.015 16.2 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 VDK88375.1 - 0.049 13.3 0.4 0.049 13.3 0.4 1.6 2 0 0 2 2 2 0 FAM176 family Bac_export_2 PF01312.19 VDK88375.1 - 0.22 10.7 0.1 0.44 9.7 0.0 1.5 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family Peptidase_C12 PF01088.21 VDK88376.1 - 1.3e-47 162.3 0.0 1.5e-47 162.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Endotoxin_C PF03944.14 VDK88377.1 - 0.025 14.9 0.6 0.052 13.9 0.6 1.5 1 0 0 1 1 1 0 delta endotoxin ADP_ribosyl_GH PF03747.14 VDK88378.1 - 9.4e-43 147.0 0.0 1.2e-42 146.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase N_formyltrans_C PF18216.1 VDK88378.1 - 0.15 11.8 0.0 0.93 9.2 0.0 2.2 2 0 0 2 2 2 0 N-formyltransferase dimerization C-terminal domain Rick_17kDa_Anti PF05433.15 VDK88378.1 - 0.21 11.5 1.0 0.49 10.3 1.0 1.6 1 0 0 1 1 1 0 Glycine zipper 2TM domain HLH PF00010.26 VDK88381.1 - 6.8e-12 45.2 0.3 1.6e-11 44.0 0.3 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Dpy19 PF10034.9 VDK88383.1 - 8.8e-63 212.6 1.6 9.7e-63 212.4 1.6 1.0 1 0 0 1 1 1 1 Q-cell neuroblast polarisation DUF2417 PF10329.9 VDK88383.1 - 0.022 14.2 0.1 0.058 12.8 0.1 1.8 1 1 0 1 1 1 0 Region of unknown function (DUF2417) Flavi_DEAD PF07652.14 VDK88383.1 - 0.14 12.2 0.1 0.72 9.8 0.0 1.9 2 0 0 2 2 2 0 Flavivirus DEAD domain Dpy19 PF10034.9 VDK88384.1 - 9.1e-88 295.1 35.3 1.1e-87 294.8 35.3 1.0 1 0 0 1 1 1 1 Q-cell neuroblast polarisation Vesiculo_matrix PF06326.12 VDK88385.1 - 0.083 12.6 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 Vesiculovirus matrix protein Arm PF00514.23 VDK88389.1 - 0.00066 19.6 0.0 1.5 8.9 0.0 3.2 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat SapB_1 PF05184.15 VDK88389.1 - 0.08 13.0 0.9 0.49 10.5 0.0 2.8 4 0 0 4 4 4 0 Saposin-like type B, region 1 Crp PF00325.20 VDK88389.1 - 0.32 10.7 2.5 13 5.5 0.1 2.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, crp family Methyltransf_11 PF08241.12 VDK88390.1 - 1.6e-13 51.1 0.0 6.5e-13 49.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 VDK88390.1 - 7.7e-12 45.4 0.0 1.1e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK88390.1 - 2.1e-11 44.4 0.0 4.7e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK88390.1 - 3.7e-10 40.4 0.0 9.4e-10 39.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK88390.1 - 4.8e-05 23.2 0.0 0.00013 21.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 VDK88390.1 - 6.4e-05 22.6 0.1 0.00011 21.9 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 VDK88390.1 - 0.00048 19.5 0.0 0.0011 18.3 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 VDK88390.1 - 0.0011 18.9 0.1 0.0018 18.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 VDK88390.1 - 0.11 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) ALG3 PF05208.13 VDK88391.1 - 6e-122 407.5 34.2 2.3e-121 405.6 34.2 1.7 1 1 0 1 1 1 1 ALG3 protein Hist_deacetyl PF00850.19 VDK88392.1 - 1.7e-53 182.1 0.0 2.1e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Tropomyosin PF00261.20 VDK88394.1 - 6.1e-50 169.8 49.8 6.8e-30 104.2 21.6 2.0 1 1 1 2 2 2 2 Tropomyosin Tropomyosin_1 PF12718.7 VDK88394.1 - 1.6e-25 89.9 53.2 7e-14 52.2 18.7 2.4 2 1 1 3 3 2 2 Tropomyosin like CCDC144C PF14915.6 VDK88394.1 - 0.015 14.5 29.2 0.021 14.0 29.2 1.2 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Prefoldin_3 PF13758.6 VDK88394.1 - 0.048 13.7 12.8 0.028 14.5 5.4 2.5 2 1 0 2 2 2 0 Prefoldin subunit SNARE PF05739.19 VDK88394.1 - 0.065 13.2 8.6 0.9 9.6 0.4 3.8 4 0 0 4 4 4 0 SNARE domain DUF1794 PF08768.11 VDK88394.1 - 0.13 12.2 2.1 6 6.8 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1794) TMP_2 PF06791.13 VDK88394.1 - 0.26 10.9 3.7 0.91 9.2 0.2 2.3 1 1 1 2 2 2 0 Prophage tail length tape measure protein Rogdi_lz PF10259.9 VDK88394.1 - 0.28 10.6 5.6 0.095 12.1 2.4 1.6 1 1 1 2 2 2 0 Rogdi leucine zipper containing protein FH2 PF02181.23 VDK88394.1 - 0.86 8.6 21.9 0.71 8.9 8.9 2.1 1 1 1 2 2 2 0 Formin Homology 2 Domain SlyX PF04102.12 VDK88394.1 - 0.91 10.2 24.1 1.3 9.6 2.8 3.5 1 1 1 3 3 3 0 SlyX Laminin_I PF06008.14 VDK88394.1 - 0.95 9.1 37.2 0.13 12.0 29.3 2.0 1 1 1 2 2 2 0 Laminin Domain I Laminin_II PF06009.12 VDK88394.1 - 1.3 9.0 23.8 1.8 8.6 5.3 2.9 1 1 2 3 3 3 0 Laminin Domain II DUF3584 PF12128.8 VDK88394.1 - 1.4 6.3 34.4 1.9 5.9 34.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Uds1 PF15456.6 VDK88394.1 - 2.4 8.3 35.8 0.51 10.5 7.2 3.2 1 1 2 3 3 3 0 Up-regulated During Septation MAD PF05557.13 VDK88394.1 - 2.7 6.3 36.1 3.3 6.0 36.1 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein TFR_dimer PF04253.15 VDK88394.1 - 2.8 8.1 16.8 1.2 9.2 2.1 3.0 1 1 2 3 3 3 0 Transferrin receptor-like dimerisation domain HOOK PF05622.12 VDK88394.1 - 3.5 5.6 36.0 44 2.0 35.6 1.9 1 1 0 1 1 1 0 HOOK protein AAA_13 PF13166.6 VDK88394.1 - 3.8 6.0 28.2 4.6 5.7 28.2 1.0 1 0 0 1 1 1 0 AAA domain TPR_MLP1_2 PF07926.12 VDK88394.1 - 4.7 7.3 44.8 3.5 7.7 8.7 3.1 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HORMA PF02301.18 VDK88394.1 - 5.1 6.6 9.1 2.6 7.6 1.2 2.4 1 1 2 3 3 3 0 HORMA domain Golgin_A5 PF09787.9 VDK88394.1 - 7.3 6.0 34.8 0.16 11.4 12.6 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 LCIB_C_CA PF18599.1 VDK88394.1 - 8 5.7 11.6 1.9 7.7 3.7 2.3 1 1 1 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases FliJ PF02050.16 VDK88394.1 - 8.4 6.6 37.4 2.3 8.5 10.4 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein DUF745 PF05335.13 VDK88394.1 - 9.5 5.9 34.6 1.9 8.2 16.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Globin PF00042.22 VDK88397.1 - 0.00024 21.6 0.0 0.00047 20.7 0.0 1.5 1 0 0 1 1 1 1 Globin Zona_pellucida PF00100.23 VDK88398.1 - 3.1e-07 30.5 0.0 4.7e-07 29.9 0.0 1.5 1 1 0 1 1 1 1 Zona pellucida-like domain KOG2701 PF09762.9 VDK88399.1 - 7.2e-63 212.0 0.2 7.2e-63 212.0 0.2 2.8 2 1 0 2 2 2 1 Coiled-coil domain-containing protein (DUF2037) RNase_HII PF01351.18 VDK88399.1 - 3e-46 157.8 1.0 1.4e-45 155.6 0.0 2.5 2 1 0 3 3 3 1 Ribonuclease HII EnY2 PF10163.9 VDK88399.1 - 3 8.3 11.3 0.16 12.4 0.7 3.6 3 1 0 3 3 3 0 Transcription factor e(y)2 Lipase_GDSL_3 PF14606.6 VDK88399.1 - 3.1 7.9 6.6 1.9 8.6 0.9 3.1 3 1 0 3 3 3 0 GDSL-like Lipase/Acylhydrolase family CLPTM1 PF05602.12 VDK88400.1 - 2e-118 396.1 1.6 2.4e-118 395.9 1.6 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 VDK88400.1 - 0.007 16.1 0.2 0.88 9.4 0.0 3.1 2 0 0 2 2 2 1 PQ loop repeat Pox_G5 PF04599.12 VDK88400.1 - 0.051 12.6 0.4 0.23 10.4 0.2 1.9 2 0 0 2 2 2 0 Poxvirus G5 protein 2-oxoacid_dh PF00198.23 VDK88402.1 - 1.1e-42 146.1 0.2 1.4e-42 145.8 0.2 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) EAL PF00563.20 VDK88402.1 - 0.02 14.4 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 EAL domain Biotin_lipoyl PF00364.22 VDK88403.1 - 2.3e-22 78.6 0.2 3.1e-22 78.2 0.2 1.2 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 VDK88403.1 - 5.1e-05 23.0 0.0 8.3e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Biotin-lipoyl like QRPTase_N PF02749.16 VDK88403.1 - 0.0068 16.4 0.1 0.019 15.0 0.0 1.7 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain PYNP_C PF07831.13 VDK88403.1 - 0.043 13.5 0.0 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain HlyD_2 PF12700.7 VDK88403.1 - 0.044 12.5 0.1 0.074 11.8 0.1 1.3 1 1 0 1 1 1 0 HlyD family secretion protein DUF2118 PF09891.9 VDK88403.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) CBS PF00571.28 VDK88407.1 - 2.8e-22 78.9 0.9 4.5e-09 36.6 0.0 4.4 4 0 0 4 4 4 3 CBS domain RNA_lig_T4_1 PF09511.10 VDK88407.1 - 0.034 14.0 0.2 0.053 13.4 0.2 1.3 1 0 0 1 1 1 0 RNA ligase Imm6 PF14434.6 VDK88407.1 - 0.1 12.5 0.4 0.22 11.5 0.4 1.5 1 0 0 1 1 1 0 Immunity protein Imm6 HABP4_PAI-RBP1 PF04774.15 VDK88409.1 - 5e-21 75.7 5.9 5e-21 75.7 5.9 2.8 2 0 0 2 2 2 1 Hyaluronan / mRNA binding family IHABP4_N PF16174.5 VDK88409.1 - 1.5e-05 25.6 9.9 1.5e-05 25.6 9.9 2.9 2 1 1 3 3 3 1 Intracellular hyaluronan-binding protein 4 N-terminal Stm1_N PF09598.10 VDK88409.1 - 5.4 7.9 9.6 4.5 8.2 5.7 3.1 2 1 0 2 2 2 0 Stm1 SOSSC PF15925.5 VDK88410.1 - 4.2e-06 28.0 1.3 0.0046 18.2 0.3 2.1 1 1 1 2 2 2 2 SOSS complex subunit C Prenyltransf PF01255.19 VDK88415.1 - 1.3e-08 34.7 0.0 1.6e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PI3_PI4_kinase PF00454.27 VDK88416.1 - 8.7e-46 156.8 1.1 5.6e-45 154.1 1.1 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 VDK88416.1 - 6e-34 117.1 0.2 1.2e-33 116.1 0.2 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_p85B PF02192.16 VDK88416.1 - 1.8e-24 85.2 0.1 3.8e-24 84.2 0.1 1.6 1 0 0 1 1 1 1 PI3-kinase family, p85-binding domain PI3K_C2 PF00792.24 VDK88416.1 - 1.3e-19 70.5 0.0 3.4e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 VDK88416.1 - 0.0052 16.9 0.0 0.087 13.0 0.0 2.7 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 VDK88416.1 - 0.0088 15.4 0.0 0.016 14.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) ADPrib_exo_Tox PF03496.14 VDK88416.1 - 0.012 15.0 0.3 0.032 13.6 0.3 1.7 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme F_actin_cap_B PF01115.17 VDK88417.1 - 4.8e-105 350.5 0.0 5.5e-105 350.3 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit CENP-C_mid PF15620.6 VDK88417.1 - 0.051 13.5 0.1 0.066 13.2 0.1 1.1 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region NMDAR2_C PF10565.9 VDK88417.1 - 0.11 11.3 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 N-methyl D-aspartate receptor 2B3 C-terminus PAN_1 PF00024.26 VDK88419.1 - 4.9e-06 26.4 1.3 1.3e-05 25.1 1.3 1.7 1 0 0 1 1 1 1 PAN domain BRICHOS PF04089.14 VDK88424.1 - 4.2e-14 52.6 0.0 6.6e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 BRICHOS domain Meckelin PF09773.9 VDK88425.1 - 2.2e-142 476.0 10.3 7.3e-79 265.9 3.9 2.9 1 1 2 3 3 3 2 Meckelin (Transmembrane protein 67) Focal_AT PF03623.13 VDK88425.1 - 0.036 14.1 0.1 0.08 12.9 0.1 1.5 1 0 0 1 1 1 0 Focal adhesion targeting region RhoGAP PF00620.27 VDK88426.1 - 2.2e-24 86.0 0.2 5e-24 84.9 0.1 1.6 2 0 0 2 2 2 1 RhoGAP domain PDZ PF00595.24 VDK88426.1 - 6.2e-07 29.7 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 PDZ domain C2 PF00168.30 VDK88426.1 - 5.8e-05 23.3 0.0 0.00013 22.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 VDK88426.1 - 0.001 18.9 0.1 0.0029 17.4 0.1 1.8 1 0 0 1 1 1 1 PDZ domain TSP_1 PF00090.19 VDK88429.1 - 7.5e-07 29.3 8.5 7.5e-07 29.3 8.5 3.5 3 1 0 3 3 3 2 Thrombospondin type 1 domain RRM_1 PF00076.22 VDK88438.1 - 0.0026 17.5 0.0 0.005 16.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SRP-alpha_N PF04086.13 VDK88438.1 - 0.55 10.1 18.1 0.7 9.8 18.1 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Menin PF05053.13 VDK88438.1 - 5.4 5.2 17.2 6.2 5.1 17.2 1.0 1 0 0 1 1 1 0 Menin RRM_1 PF00076.22 VDK88440.1 - 3.1e-16 59.0 0.0 6.6e-15 54.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 VDK88440.1 - 0.00078 19.4 0.1 0.0081 16.1 0.1 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 VDK88440.1 - 0.0018 17.9 0.0 0.005 16.4 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apt1 PF10351.9 VDK88440.1 - 0.33 9.7 18.4 0.42 9.4 18.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 VDK88440.1 - 1.7 7.3 15.4 2.2 7.0 15.4 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 VDK88440.1 - 2.6 6.2 21.9 3.3 5.9 21.9 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4551 PF15087.6 VDK88440.1 - 3.4 6.4 16.1 4 6.1 16.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SOBP PF15279.6 VDK88440.1 - 9.9 6.7 15.3 13 6.3 15.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein LSM PF01423.22 VDK88441.1 - 1.3e-18 66.4 0.9 1.7e-18 66.0 0.9 1.2 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.8 VDK88441.1 - 0.088 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) zf-RING_2 PF13639.6 VDK88445.1 - 2.3e-10 40.7 7.3 5.9e-10 39.3 7.3 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 VDK88445.1 - 9.1e-07 28.5 4.4 9.1e-07 28.5 4.4 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 VDK88445.1 - 0.00017 21.4 6.8 0.00038 20.2 6.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK88445.1 - 0.0012 19.0 8.2 0.006 16.9 8.2 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain PA PF02225.22 VDK88445.1 - 0.0096 15.9 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 PA domain FANCL_C PF11793.8 VDK88445.1 - 0.02 15.1 5.4 0.14 12.4 5.4 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain Cadherin_C_2 PF16492.5 VDK88445.1 - 0.021 15.5 0.2 0.056 14.2 0.2 1.7 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal RINGv PF12906.7 VDK88445.1 - 0.041 14.0 5.7 0.11 12.6 5.7 1.8 1 0 0 1 1 1 0 RING-variant domain zf-C3HC4_3 PF13920.6 VDK88445.1 - 0.046 13.6 5.7 0.12 12.3 5.7 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Oxidored_q2 PF00420.24 VDK88445.1 - 0.17 11.5 0.1 0.34 10.6 0.1 1.4 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Prok-RING_4 PF14447.6 VDK88445.1 - 0.21 11.5 4.3 0.59 10.0 4.3 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 VDK88445.1 - 0.26 11.3 5.4 0.69 9.9 5.4 1.8 1 0 0 1 1 1 0 zinc-RING finger domain CBP_BcsF PF11120.8 VDK88445.1 - 0.64 10.2 2.1 1.4 9.1 2.1 1.5 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsF Med26 PF08711.11 VDK88447.1 - 3.4e-12 46.2 0.0 7.4e-12 45.1 0.0 1.6 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ground-like PF04155.18 VDK88449.1 - 4.4e-19 68.9 4.6 6.6e-19 68.3 4.6 1.3 1 0 0 1 1 1 1 Ground-like domain Iso_dh PF00180.20 VDK88451.1 - 1.6e-73 247.9 0.1 1.9e-73 247.6 0.1 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Bromo_TP PF07524.13 VDK88451.1 - 0.039 14.0 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 Bromodomain associated zf-C2H2 PF00096.26 VDK88463.1 - 0.00026 21.3 1.7 0.0012 19.2 0.0 2.8 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 VDK88463.1 - 0.0022 17.9 0.0 0.0065 16.5 0.0 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf_ZIC PF18366.1 VDK88463.1 - 0.0034 17.4 0.1 0.0071 16.4 0.1 1.5 1 0 0 1 1 1 1 Zic proteins zinc finger domain zf-C2H2_4 PF13894.6 VDK88463.1 - 0.0068 17.2 0.8 0.044 14.6 0.0 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger adh_short PF00106.25 VDK88466.1 - 6.9e-34 117.0 0.2 8.4e-34 116.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDK88466.1 - 8.3e-25 87.7 0.0 1.1e-24 87.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDK88466.1 - 1.1e-05 25.4 0.0 1.4e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 KR domain HATPase_c_2 PF13581.6 VDK88466.1 - 0.17 11.9 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain DUF727 PF05303.12 VDK88467.1 - 6.6e-31 106.5 0.0 1.5e-30 105.4 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF727) PH PF00169.29 VDK88467.1 - 0.0029 18.1 0.0 0.0079 16.7 0.0 1.8 1 0 0 1 1 1 1 PH domain PDZ_6 PF17820.1 VDK88467.1 - 0.0048 16.7 0.3 0.4 10.6 0.1 2.6 2 0 0 2 2 2 1 PDZ domain RhoGAP PF00620.27 VDK88468.1 - 5.8e-29 100.9 4.4 7.5e-29 100.5 0.1 2.8 2 1 1 3 3 3 1 RhoGAP domain BAR PF03114.18 VDK88468.1 - 7.2e-06 25.8 12.1 9.7e-06 25.4 12.1 1.2 1 0 0 1 1 1 1 BAR domain Rer1 PF03248.13 VDK88473.1 - 2.8e-72 242.0 10.2 3.2e-72 241.8 10.2 1.0 1 0 0 1 1 1 1 Rer1 family WD40 PF00400.32 VDK88474.1 - 2.8e-20 72.2 8.0 3.6e-07 30.8 0.2 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat Lactonase PF10282.9 VDK88474.1 - 0.013 14.8 0.0 0.067 12.4 0.0 2.0 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller UxaE PF16257.5 VDK88475.1 - 0.23 10.1 0.0 0.32 9.6 0.0 1.1 1 0 0 1 1 1 0 tagaturonate epimerase Lipase_2 PF01674.18 VDK88476.1 - 5.9e-69 231.9 0.0 7.2e-69 231.7 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 2) Palm_thioest PF02089.15 VDK88476.1 - 0.0039 17.1 0.0 0.0054 16.6 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase TFIIA PF03153.13 VDK88486.1 - 4.1 7.3 5.9 5.6 6.8 5.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Homeodomain PF00046.29 VDK88489.1 - 2.2e-21 75.4 2.0 3.8e-21 74.7 2.0 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDK88489.1 - 0.0041 17.0 0.1 0.0094 15.8 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain CHCH PF06747.13 VDK88490.1 - 0.0034 17.5 2.2 0.0043 17.2 0.7 1.9 2 0 0 2 2 2 1 CHCH domain Ndufs5 PF10200.9 VDK88490.1 - 0.086 13.1 0.8 0.092 13.0 0.8 1.1 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Serpin PF00079.20 VDK88496.1 - 0.046 13.0 0.0 0.32 10.3 0.0 2.0 2 0 0 2 2 2 0 Serpin (serine protease inhibitor) Mur_ligase_M PF08245.12 VDK88497.1 - 2.7e-07 30.8 0.1 1.4e-06 28.4 0.1 2.1 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 VDK88497.1 - 0.0015 18.7 0.0 0.0041 17.3 0.0 1.7 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain CDC27 PF09507.10 VDK88498.1 - 1.3e-17 64.3 33.8 2.2e-12 47.1 0.3 2.0 1 1 1 2 2 2 2 DNA polymerase subunit Cdc27 zf-C4 PF00105.18 VDK88504.1 - 9.3e-29 99.7 15.1 1.6e-28 98.9 15.1 1.4 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Hormone_recep PF00104.30 VDK88504.1 - 9.6e-13 48.2 0.0 1.6e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Ank_2 PF12796.7 VDK88515.1 - 4e-27 94.6 9.9 8.9e-13 48.6 0.1 3.5 2 1 3 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK88515.1 - 5.3e-16 58.8 5.8 1.8e-08 34.8 0.4 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 VDK88515.1 - 1.6e-14 53.6 10.3 8.1e-05 22.9 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat SAM_1 PF00536.30 VDK88515.1 - 3.5e-14 53.0 0.1 7.3e-14 52.0 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_3 PF13606.6 VDK88515.1 - 7.1e-14 50.6 2.6 0.0015 18.8 0.0 5.7 6 0 0 6 6 5 3 Ankyrin repeat Ank_5 PF13857.6 VDK88515.1 - 7.1e-13 48.5 6.1 8.1e-06 26.0 0.5 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) SAM_2 PF07647.17 VDK88515.1 - 1.1e-10 41.4 0.2 2.4e-10 40.3 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) YjgF_endoribonc PF14588.6 VDK88515.1 - 0.025 14.7 0.5 1.2 9.2 0.1 2.5 2 0 0 2 2 2 0 YjgF/chorismate_mutase-like, putative endoribonuclease Sec8_exocyst PF04048.14 VDK88515.1 - 0.039 13.8 0.6 0.094 12.6 0.6 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Prefoldin_2 PF01920.20 VDK88515.1 - 0.066 13.2 6.2 0.27 11.2 2.6 2.6 1 1 1 2 2 2 0 Prefoldin subunit V-SNARE PF05008.15 VDK88515.1 - 0.12 12.7 4.5 0.24 11.8 1.5 2.7 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF1712 PF08217.11 VDK88516.1 - 1e-26 93.6 11.3 4.2e-18 65.2 1.4 4.0 1 1 2 3 3 3 3 Fungal domain of unknown function (DUF1712) F-box PF00646.33 VDK88520.1 - 0.055 13.4 0.0 0.16 11.9 0.0 1.8 1 0 0 1 1 1 0 F-box domain Glyco_hydro_99 PF16317.5 VDK88521.1 - 1.7e-108 362.8 4.6 2.2e-108 362.4 4.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 DUF4366 PF14283.6 VDK88532.1 - 0.099 12.7 0.1 0.12 12.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Y_phosphatase PF00102.27 VDK88533.1 - 2.4e-74 249.8 2.8 3.8e-74 249.2 2.8 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PID PF00640.23 VDK88533.1 - 5.5e-20 71.8 0.9 1.5e-19 70.4 0.0 2.3 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) PID_2 PF14719.6 VDK88533.1 - 6.4e-05 22.9 0.2 0.00017 21.5 0.0 1.8 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) DSPc PF00782.20 VDK88533.1 - 0.0038 17.0 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 VDK88533.1 - 0.036 14.0 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family PTB PF08416.13 VDK88533.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotyrosine-binding domain CDKN3 PF05706.12 VDK88533.1 - 0.11 12.1 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) CAP_N PF01213.19 VDK88541.1 - 3.6e-84 282.9 2.5 4.1e-84 282.8 1.0 1.8 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 VDK88541.1 - 2.2e-62 209.3 8.1 4.5e-62 208.3 8.1 1.5 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 VDK88541.1 - 0.00014 21.6 4.3 0.00032 20.4 4.3 1.6 1 0 0 1 1 1 1 Tubulin binding cofactor C WH2 PF02205.20 VDK88541.1 - 0.033 14.0 0.0 0.088 12.7 0.0 1.7 1 0 0 1 1 1 0 WH2 motif DUF2868 PF11067.8 VDK88542.1 - 0.004 16.7 0.1 0.0046 16.5 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2868) CAP_N PF01213.19 VDK88542.1 - 0.023 14.2 0.0 0.025 14.1 0.0 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal RF-1 PF00472.20 VDK88547.1 - 6.8e-20 71.1 1.7 9.1e-20 70.7 1.7 1.1 1 0 0 1 1 1 1 RF-1 domain MRP-S28 PF10213.9 VDK88547.1 - 0.042 14.3 1.0 0.052 14.0 1.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit protein Bac_DnaA PF00308.18 VDK88547.1 - 0.066 13.0 0.1 0.079 12.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial dnaA protein Ribosomal_L35Ae PF01247.18 VDK88548.1 - 2e-43 146.5 2.6 2.9e-43 145.9 2.6 1.2 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 VDK88548.1 - 0.0024 18.1 0.1 2.8 8.2 0.0 2.3 2 0 0 2 2 2 2 RimM N-terminal domain Tetraspanin PF00335.20 VDK88550.1 - 1.2e-56 192.1 4.6 1.5e-56 191.7 4.6 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF5362 PF17319.2 VDK88550.1 - 0.008 16.0 0.9 3.1 7.7 0.0 2.7 2 0 0 2 2 2 2 Family of unknown function (DUF5362) PIG-S PF10510.9 VDK88552.1 - 1.2e-63 215.8 9.2 1.6e-63 215.4 9.2 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein IPP-2 PF04979.14 VDK88553.1 - 6.1e-20 72.3 0.0 8.8e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) Collagen PF01391.18 VDK88558.1 - 1.3e-21 76.1 89.6 1.2e-06 28.1 41.8 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDK88558.1 - 0.0036 17.3 0.1 0.0048 16.9 0.1 1.2 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain CaKB PF03185.15 VDK88558.1 - 0.0085 15.8 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 Calcium-activated potassium channel, beta subunit NADH5_C PF06455.11 VDK88559.1 - 0.17 11.5 1.4 0.21 11.2 0.0 1.8 2 0 0 2 2 2 0 NADH dehydrogenase subunit 5 C-terminus Na_K-ATPase PF00287.18 VDK88563.1 - 1.8e-19 70.0 4.4 4.4e-19 68.7 4.7 1.4 2 0 0 2 2 2 1 Sodium / potassium ATPase beta chain Tetraspanin PF00335.20 VDK88563.1 - 0.018 14.8 1.1 0.026 14.3 1.1 1.2 1 0 0 1 1 1 0 Tetraspanin family LCE PF14672.6 VDK88565.1 - 0.051 14.2 1.0 0.11 13.1 1.0 1.6 1 0 0 1 1 1 0 Late cornified envelope TH1 PF04858.13 VDK88566.1 - 1.1e-67 229.0 0.0 1.4e-67 228.6 0.0 1.0 1 0 0 1 1 1 1 TH1 protein DUF3504 PF12012.8 VDK88566.1 - 0.052 13.4 0.3 0.11 12.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) Rieske PF00355.26 VDK88569.1 - 2.7e-15 56.1 0.0 5.1e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 VDK88569.1 - 2.4e-08 33.9 0.0 3.7e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF5021 PF16424.5 VDK88569.1 - 0.043 13.7 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5021) Spectrin PF00435.21 VDK88570.1 - 5e-177 576.6 146.6 3.8e-18 65.9 5.4 16.2 15 1 0 15 15 15 15 Spectrin repeat PH_9 PF15410.6 VDK88570.1 - 2e-13 50.7 0.4 1.3e-12 48.2 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 VDK88570.1 - 1.3e-11 44.9 0.6 5.4e-11 42.9 0.1 2.4 2 0 0 2 2 2 1 PH domain ABC_tran_CTD PF16326.5 VDK88570.1 - 0.0058 16.8 2.8 0.0058 16.8 2.8 12.5 13 1 0 13 13 13 2 ABC transporter C-terminal domain HisKA_2 PF07568.12 VDK88570.1 - 0.047 13.8 2.5 5.6 7.1 0.8 4.2 3 0 0 3 3 3 0 Histidine kinase DIL PF01843.19 VDK88570.1 - 8.6 6.7 9.6 2.1 8.7 0.1 4.9 3 1 1 4 4 4 0 DIL domain Syja_N PF02383.18 VDK88573.1 - 1.7e-68 231.3 0.0 2.8e-68 230.6 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain DUF1866 PF08952.11 VDK88573.1 - 6.6e-13 48.7 0.1 2.3e-12 47.0 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1866) Exo_endo_phos PF03372.23 VDK88573.1 - 1.7e-12 47.4 0.0 2.5e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PhoLip_ATPase_C PF16212.5 VDK88574.1 - 1.2e-80 270.8 34.7 1.6e-80 270.5 34.7 1.1 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 VDK88574.1 - 3.6e-12 46.2 0.0 5.4e-11 42.4 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 VDK88574.1 - 2.3e-10 41.1 1.0 3.3e-05 24.3 0.5 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 VDK88574.1 - 0.0038 17.0 0.2 0.016 14.9 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase FA_desaturase PF00487.24 VDK88579.1 - 1.7e-11 44.4 2.7 3.5e-11 43.4 2.7 1.4 2 0 0 2 2 2 1 Fatty acid desaturase MttA_Hcf106 PF02416.16 VDK88580.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 mttA/Hcf106 family PDZ PF00595.24 VDK88581.1 - 4.9e-55 183.8 0.1 1.8e-14 53.8 0.1 4.2 4 0 0 4 4 4 4 PDZ domain PDZ_6 PF17820.1 VDK88581.1 - 2.5e-39 132.9 0.1 2.2e-10 40.2 0.0 4.5 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 VDK88581.1 - 6e-20 71.3 0.1 0.0017 18.6 0.0 4.4 4 0 0 4 4 4 4 PDZ domain Tricorn_PDZ PF14685.6 VDK88581.1 - 2.2e-05 24.4 0.2 1.3 9.1 0.0 3.6 3 0 0 3 3 3 3 Tricorn protease PDZ domain GRASP55_65 PF04495.14 VDK88581.1 - 2.6e-05 24.6 0.0 0.64 10.3 0.0 3.6 2 1 2 4 4 4 2 GRASP55/65 PDZ-like domain DUF5301 PF17225.3 VDK88581.1 - 0.031 14.7 0.2 0.087 13.3 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) Trypsin PF00089.26 VDK88585.1 - 0.019 14.8 0.0 0.02 14.7 0.0 1.1 1 0 0 1 1 1 0 Trypsin Pkinase PF00069.25 VDK88586.1 - 2.4e-06 27.1 1.0 4.2e-06 26.3 1.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Nkap_C PF06047.11 VDK88588.1 - 2.2e-41 140.1 3.7 2.2e-41 140.1 3.7 3.6 5 0 0 5 5 5 1 NF-kappa-B-activating protein C-terminal domain G-patch PF01585.23 VDK88593.1 - 5.4e-12 45.4 0.0 9.3e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 G-patch domain zf_CCCH_4 PF18345.1 VDK88593.1 - 5e-05 23.2 2.7 8.6e-05 22.5 2.7 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 VDK88593.1 - 7.3e-05 22.5 3.1 0.00014 21.6 3.1 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 VDK88593.1 - 0.00043 20.1 2.3 0.00074 19.4 2.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 VDK88593.1 - 0.00082 19.8 1.5 0.0022 18.4 1.5 1.8 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger LMBR1 PF04791.16 VDK88593.1 - 0.7 8.7 3.4 1.1 8.1 3.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA PF00004.29 VDK88594.1 - 2.1e-38 131.7 0.0 3.9e-38 130.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 VDK88594.1 - 2.3e-11 43.3 0.0 4.6e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 VDK88594.1 - 1.4e-07 31.4 0.1 1.6e-06 28.0 0.0 2.8 3 1 1 4 4 4 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 VDK88594.1 - 2.1e-06 27.6 0.0 5e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 VDK88594.1 - 1.8e-05 24.7 0.1 0.00011 22.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 VDK88594.1 - 0.0017 18.5 0.0 0.0034 17.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 VDK88594.1 - 0.002 17.4 0.0 0.004 16.4 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 VDK88594.1 - 0.0022 18.4 0.3 0.01 16.3 0.3 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 VDK88594.1 - 0.0024 18.1 0.6 0.058 13.7 0.6 2.6 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 VDK88594.1 - 0.012 15.0 0.1 4.9 6.5 0.0 2.4 1 1 1 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 VDK88594.1 - 0.021 14.2 0.0 0.044 13.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 VDK88594.1 - 0.026 14.1 0.1 0.64 9.6 0.0 2.2 1 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 VDK88594.1 - 0.032 14.6 0.0 0.066 13.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 VDK88594.1 - 0.054 13.3 0.3 0.24 11.2 0.0 2.1 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system ATPase PF06745.13 VDK88594.1 - 0.085 12.2 0.9 7.1 5.9 0.2 2.3 1 1 1 2 2 2 0 KaiC AAA_18 PF13238.6 VDK88594.1 - 0.1 13.1 0.0 0.26 11.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 VDK88594.1 - 0.11 11.9 0.0 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AZUL PF16558.5 VDK88598.1 - 1.5e-08 34.7 3.6 1.5e-08 34.7 3.6 2.2 2 0 0 2 2 2 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A DNA_ligase_A_N PF04675.14 VDK88598.1 - 0.077 13.3 0.2 14 5.9 0.0 2.5 2 0 0 2 2 2 0 DNA ligase N terminus Zona_pellucida PF00100.23 VDK88605.1 - 1.3e-05 25.2 2.0 0.017 14.9 1.0 2.6 1 1 1 2 2 2 2 Zona pellucida-like domain ZU5 PF00791.20 VDK88606.1 - 1.1e-30 105.8 0.3 3.6e-30 104.2 0.0 2.0 2 0 0 2 2 2 1 ZU5 domain PDZ PF00595.24 VDK88606.1 - 6.8e-22 77.6 0.5 3.5e-10 40.1 0.3 2.6 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK88606.1 - 1.7e-16 59.8 0.1 3.4e-07 30.0 0.0 2.6 2 0 0 2 2 2 2 PDZ domain Guanylate_kin PF00625.21 VDK88606.1 - 1.9e-10 40.7 0.1 1.1e-09 38.3 0.1 2.1 1 1 1 2 2 2 1 Guanylate kinase PDZ_2 PF13180.6 VDK88606.1 - 1.6e-08 34.8 0.9 1.4e-05 25.3 0.2 2.5 2 0 0 2 2 2 2 PDZ domain SH3_2 PF07653.17 VDK88606.1 - 0.027 14.1 0.0 0.064 12.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Tricorn_PDZ PF14685.6 VDK88606.1 - 0.034 14.1 0.0 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Tricorn protease PDZ domain LIN52 PF10044.9 VDK88614.1 - 3.3e-25 88.6 0.0 4.4e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 Retinal tissue protein DUF2164 PF09932.9 VDK88614.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2164) BTB PF00651.31 VDK88615.1 - 0.00029 21.0 0.0 0.00089 19.5 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain GcpE PF04551.14 VDK88615.1 - 0.19 10.8 0.1 0.22 10.6 0.1 1.2 1 0 0 1 1 1 0 GcpE protein LRR_4 PF12799.7 VDK88616.1 - 2.4e-15 56.4 4.7 7.7e-07 29.3 0.3 3.4 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDK88616.1 - 5.9e-13 48.7 0.0 8.7e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 VDK88616.1 - 2e-11 43.5 7.2 8.1e-05 22.3 0.0 3.8 2 1 2 4 4 4 4 Leucine rich repeat LRR_6 PF13516.6 VDK88616.1 - 4.9e-05 23.1 7.6 0.65 10.2 0.0 5.4 6 0 0 6 6 6 2 Leucine Rich repeat LRR_1 PF00560.33 VDK88616.1 - 0.37 11.5 11.9 16 6.5 0.6 5.1 5 1 0 5 5 5 0 Leucine Rich Repeat SDA1 PF05285.12 VDK88616.1 - 0.82 9.0 21.1 1.2 8.4 21.1 1.2 1 0 0 1 1 1 0 SDA1 MBD_C PF14048.6 VDK88617.1 - 1e-21 77.4 0.1 2.3e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of methyl-CpG binding protein 2 and 3 MBDa PF16564.5 VDK88617.1 - 4.8e-10 39.5 2.4 1.3e-08 34.9 2.4 2.5 1 1 0 1 1 1 1 p55-binding region of Methyl-CpG-binding domain proteins MBD DUF2564 PF10819.8 VDK88617.1 - 0.048 14.1 0.2 0.14 12.6 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2564) Pro-NT_NN PF07421.11 VDK88617.1 - 0.063 13.5 0.1 0.084 13.1 0.1 1.4 1 1 0 1 1 1 0 Neurotensin/neuromedin N precursor Cyt-b5 PF00173.28 VDK88619.1 - 5e-19 68.2 0.0 9.8e-19 67.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.24 VDK88619.1 - 8.8e-13 48.5 0.0 1.8e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 VDK88619.1 - 7.4e-09 36.2 0.0 1.3e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Glutaredoxin PF00462.24 VDK88620.1 - 2.7e-15 56.3 0.2 6.7e-15 55.1 0.0 1.7 2 0 0 2 2 2 1 Glutaredoxin GST_N_3 PF13417.6 VDK88620.1 - 0.0039 17.6 0.0 0.0054 17.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Pyr_redox_2 PF07992.14 VDK88620.1 - 0.0045 16.2 0.0 0.0051 16.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GST_N_2 PF13409.6 VDK88620.1 - 0.1 12.9 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 VDK88620.1 - 0.17 12.3 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Annexin PF00191.20 VDK88622.1 - 1.2e-45 153.4 9.3 2.5e-25 88.3 0.3 4.1 3 1 0 3 3 3 3 Annexin FeoB_Cyto PF17910.1 VDK88622.1 - 0.053 14.1 0.8 31 5.2 0.0 3.3 3 1 0 3 3 3 0 FeoB cytosolic helical domain OST-HTH PF12872.7 VDK88622.1 - 0.47 10.3 1.9 9.4 6.1 0.0 3.2 3 1 1 4 4 4 0 OST-HTH/LOTUS domain Thioredoxin_8 PF13905.6 VDK88623.1 - 5.4e-23 81.1 0.0 5.5e-21 74.7 0.0 2.5 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 VDK88623.1 - 7.6e-05 23.1 0.0 0.0074 16.7 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.20 VDK88623.1 - 0.0016 18.4 0.1 0.17 11.9 0.1 2.6 1 1 1 2 2 2 1 Thioredoxin AhpC-TSA PF00578.21 VDK88623.1 - 0.0057 16.6 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDK88623.1 - 0.042 13.6 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Redoxin Thioredoxin_6 PF13848.6 VDK88623.1 - 0.075 12.9 0.0 0.31 10.9 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like domain WD40 PF00400.32 VDK88626.1 - 1.1e-08 35.5 5.0 0.14 13.1 0.4 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK88626.1 - 1.2e-06 28.7 1.0 0.023 15.0 0.1 4.5 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1433 PF07252.11 VDK88626.1 - 0.095 13.0 0.5 0.2 11.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1433) Astacin PF01400.24 VDK88628.1 - 3.5e-68 229.0 0.1 6.2e-68 228.2 0.1 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 VDK88628.1 - 4.1e-05 23.5 0.8 0.12 12.2 0.1 2.3 2 0 0 2 2 2 2 Matrixin CUB PF00431.20 VDK88628.1 - 0.0015 18.8 0.1 0.0037 17.6 0.1 1.6 1 0 0 1 1 1 1 CUB domain Peptidase_M66 PF10462.9 VDK88628.1 - 0.0048 15.9 0.2 0.0095 14.9 0.2 1.4 1 0 0 1 1 1 1 Peptidase M66 Forkhead PF00250.18 VDK88628.1 - 0.039 14.2 0.7 0.13 12.5 0.1 2.2 2 0 0 2 2 2 0 Forkhead domain Reprolysin_4 PF13583.6 VDK88628.1 - 0.042 13.5 0.2 0.1 12.2 0.2 1.6 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 VDK88628.1 - 0.058 12.0 0.0 0.092 11.3 0.0 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M57 PF12388.8 VDK88628.1 - 0.081 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase SIX1_SD PF16878.5 VDK88631.1 - 1.2e-43 148.1 0.2 1.2e-43 148.1 0.2 2.2 3 0 0 3 3 3 1 Transcriptional regulator, SIX1, N-terminal SD domain Homeodomain PF00046.29 VDK88631.1 - 1.4e-11 44.1 1.0 1.4e-11 44.1 1.0 2.2 3 0 0 3 3 3 1 Homeodomain Homeobox_KN PF05920.11 VDK88631.1 - 4.4e-10 39.3 0.3 9.5e-10 38.2 0.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain SHR3_chaperone PF08229.11 VDK88631.1 - 0.21 10.6 0.2 0.37 9.7 0.2 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 G-alpha PF00503.20 VDK88633.1 - 7e-99 331.3 11.4 8.9e-99 331.0 11.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 VDK88633.1 - 4.6e-15 55.5 1.0 1.3e-11 44.3 0.2 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 VDK88633.1 - 0.0017 18.4 0.0 3.3 7.8 0.0 2.8 2 1 0 2 2 2 2 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 VDK88633.1 - 0.0028 17.0 6.7 0.011 15.1 0.6 2.7 2 1 1 3 3 3 1 Gtr1/RagA G protein conserved region Roc PF08477.13 VDK88633.1 - 0.0051 17.0 0.7 0.78 10.0 0.0 2.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 VDK88633.1 - 0.008 15.8 0.4 1.6 8.3 0.1 2.9 2 1 0 2 2 2 1 Ras family GTP_EFTU PF00009.27 VDK88633.1 - 0.036 13.6 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 VDK88633.1 - 0.056 12.8 0.1 0.3 10.4 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family MCM PF00493.23 VDK88633.1 - 0.11 11.6 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 VDK88633.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 VDK88633.1 - 0.12 12.2 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CoA_binding PF02629.19 VDK88634.1 - 7.9e-28 97.0 1.1 7.9e-28 97.0 1.1 2.0 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 VDK88634.1 - 1.5e-23 83.3 1.0 3.9e-23 82.0 0.1 2.0 2 0 0 2 2 2 1 CoA-ligase Succ_CoA_lig PF13607.6 VDK88634.1 - 2.3e-08 34.0 0.0 4.4e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 VDK88634.1 - 0.0027 18.2 0.1 0.0065 17.0 0.1 1.6 1 0 0 1 1 1 1 CoA binding domain TraB PF01963.17 VDK88635.1 - 5.5e-18 65.8 0.0 6.4e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 TraB family Vmethyltransf PF01660.17 VDK88635.1 - 0.051 12.5 0.0 0.067 12.1 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase zf-RING_2 PF13639.6 VDK88638.1 - 1.9e-12 47.3 5.4 1.9e-12 47.3 5.4 2.2 3 0 0 3 3 2 1 Ring finger domain zf-RING_11 PF17123.5 VDK88638.1 - 5.8e-10 38.7 2.2 1.4e-09 37.5 2.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 VDK88638.1 - 2.5e-09 36.8 6.8 5.6e-09 35.7 3.5 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDK88638.1 - 7.4e-09 35.8 2.5 3.3e-08 33.7 2.5 2.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 VDK88638.1 - 2.7e-07 30.3 3.0 2.7e-07 30.3 3.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK88638.1 - 5.5e-06 26.2 2.9 5.5e-06 26.2 2.9 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Mucin PF01456.17 VDK88638.1 - 0.00012 22.1 22.1 0.00051 20.0 5.3 2.2 2 0 0 2 2 2 2 Mucin-like glycoprotein zf-RING_UBOX PF13445.6 VDK88638.1 - 0.00014 21.8 3.0 0.0005 20.0 3.0 2.0 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 VDK88638.1 - 0.00049 19.9 2.6 0.0015 18.3 2.6 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 VDK88638.1 - 0.0061 16.4 2.0 0.0061 16.4 2.0 2.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 VDK88638.1 - 0.046 13.8 1.4 0.12 12.4 1.4 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 VDK88638.1 - 0.11 12.4 2.9 0.25 11.3 2.9 1.7 1 0 0 1 1 1 0 PHD-finger ZNRF_3_ecto PF18212.1 VDK88638.1 - 0.12 12.3 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 ZNRF-3 Ectodomain SMC_hinge PF06470.13 VDK88638.1 - 0.12 12.6 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain FANCL_C PF11793.8 VDK88638.1 - 1.9 8.7 5.5 1.4 9.1 3.2 2.1 2 1 0 2 2 1 0 FANCL C-terminal domain DUF2057 PF09829.9 VDK88638.1 - 7.7 6.6 9.0 3 8.0 2.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Cyt-b5 PF00173.28 VDK88639.1 - 7.4e-13 48.4 0.1 1.3e-12 47.6 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Clathrin_lg_ch PF01086.17 VDK88643.1 - 5.8e-25 88.7 12.8 6.3e-25 88.6 12.8 1.0 1 0 0 1 1 1 1 Clathrin light chain DUF2115 PF09888.9 VDK88643.1 - 0.14 12.7 0.6 0.15 12.6 0.6 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) Metallophos PF00149.28 VDK88644.1 - 2.2e-32 113.2 0.6 3.9e-32 112.4 0.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 VDK88644.1 - 4.5e-32 110.2 1.2 8.4e-32 109.3 0.7 1.8 2 0 0 2 2 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 VDK88644.1 - 5e-11 41.9 12.3 5.9e-05 22.7 0.7 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 VDK88644.1 - 5.8e-09 35.4 16.2 0.00058 19.8 0.7 4.5 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 VDK88644.1 - 1.3e-06 28.4 2.3 0.014 15.7 0.2 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 VDK88644.1 - 5e-05 22.9 9.0 0.0063 16.2 0.9 3.5 2 1 2 4 4 4 3 TPR repeat TPR_8 PF13181.6 VDK88644.1 - 0.00014 21.8 13.1 0.66 10.3 0.6 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 VDK88644.1 - 0.00054 20.6 5.2 0.01 16.4 2.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 VDK88644.1 - 0.00066 19.8 0.1 0.0015 18.6 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 VDK88644.1 - 0.0014 19.1 6.9 0.019 15.4 1.6 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDK88644.1 - 0.0053 17.5 4.0 0.25 12.2 0.3 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 VDK88644.1 - 0.019 15.4 0.3 0.036 14.5 0.3 1.4 1 0 0 1 1 1 0 Bacterial transcriptional activator domain TPR_12 PF13424.6 VDK88644.1 - 0.034 14.4 6.6 0.89 9.9 1.4 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK88644.1 - 1.9 9.3 4.1 2.8 8.8 0.8 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat I-set PF07679.16 VDK88647.1 - 5.5e-127 414.2 30.4 9e-16 57.7 0.2 14.8 15 0 0 15 15 14 13 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK88647.1 - 1.3e-85 282.0 9.4 1.9e-12 47.6 0.0 14.0 13 0 0 13 13 13 12 Immunoglobulin domain fn3 PF00041.21 VDK88647.1 - 6.8e-78 257.1 7.5 1.4e-16 60.6 0.0 7.5 7 0 0 7 7 7 6 Fibronectin type III domain Ig_2 PF13895.6 VDK88647.1 - 1.8e-43 146.7 8.6 6.9e-10 39.1 0.0 12.4 12 0 0 12 12 12 5 Immunoglobulin domain ig PF00047.25 VDK88647.1 - 8.6e-37 125.2 9.4 4.9e-08 33.0 0.0 11.5 11 0 0 11 11 11 7 Immunoglobulin domain V-set PF07686.17 VDK88647.1 - 2.6e-21 75.9 14.2 0.24 11.6 0.0 14.2 11 5 0 11 11 11 5 Immunoglobulin V-set domain Izumo-Ig PF16706.5 VDK88647.1 - 8.9e-09 35.3 7.2 0.39 10.8 0.0 7.3 7 0 0 7 7 6 3 Izumo-like Immunoglobulin domain fn3_2 PF16893.5 VDK88647.1 - 1.8e-07 31.2 0.0 1.9 8.7 0.0 5.9 6 0 0 6 6 5 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDK88647.1 - 1.3e-06 28.9 20.8 0.13 12.9 0.0 9.1 9 0 0 9 9 8 2 Purple acid Phosphatase, N-terminal domain C2-set_2 PF08205.12 VDK88647.1 - 3.3e-05 23.9 0.1 0.72 10.0 0.0 5.1 4 0 0 4 4 4 1 CD80-like C2-set immunoglobulin domain Receptor_2B4 PF11465.8 VDK88647.1 - 0.00036 20.7 22.5 18 5.6 0.0 12.5 12 2 2 14 14 14 0 Natural killer cell receptor 2B4 Herpes_gE PF02480.16 VDK88647.1 - 0.00044 19.1 2.2 0.73 8.5 0.1 4.2 3 2 0 4 4 4 2 Alphaherpesvirus glycoprotein E Ig_4 PF16680.5 VDK88647.1 - 0.00055 20.1 25.7 0.04 14.2 0.2 8.6 11 0 0 11 11 6 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 VDK88647.1 - 0.00059 19.3 0.0 0.28 10.8 0.0 4.1 4 0 0 4 4 4 1 Immunoglobulin domain Tissue_fac PF01108.17 VDK88647.1 - 0.0013 18.5 0.0 0.22 11.4 0.0 3.8 3 0 0 3 3 3 1 Tissue factor UL141 PF16758.5 VDK88647.1 - 0.13 12.0 0.9 0.51 10.0 0.0 2.4 3 0 0 3 3 3 0 Herpes-like virus membrane glycoprotein UL141 DUF2369 PF10179.9 VDK88647.1 - 1.2 9.6 9.4 4.1 7.8 0.2 5.4 6 1 0 6 6 5 0 Uncharacterised conserved protein (DUF2369) L71 PF02448.15 VDK88647.1 - 8.7 6.8 5.8 7.2 7.1 0.2 3.2 3 0 0 3 3 3 0 L71 family CBM_14 PF01607.24 VDK88648.1 - 5.3e-52 173.8 136.3 1.5e-11 44.2 5.6 14.6 9 4 5 14 14 14 12 Chitin binding Peritrophin-A domain Calcyon PF06387.11 VDK88648.1 - 0.5 10.3 2.9 0.45 10.5 0.6 2.1 2 0 0 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) RabGAP-TBC PF00566.18 VDK88650.1 - 7.7e-42 143.4 1.0 1.7e-41 142.3 1.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 VDK88650.1 - 0.0096 15.4 4.3 0.32 10.5 0.2 2.8 3 0 0 3 3 3 2 Rab-binding domain (RBD) DUF4820 PF16091.5 VDK88650.1 - 0.58 9.5 5.8 2.6 7.4 5.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) 7tm_1 PF00001.21 VDK88654.1 - 4.9e-05 22.8 13.7 6.7e-05 22.3 13.7 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DM PF00751.18 VDK88661.1 - 1.6e-27 95.2 34.1 2.8e-16 59.1 7.5 3.3 3 0 0 3 3 3 3 DM DNA binding domain KH_8 PF17903.1 VDK88662.1 - 0.021 14.9 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 Krr1 KH1 domain KH_1 PF00013.29 VDK88662.1 - 0.023 14.5 0.5 0.068 13.0 0.5 1.8 1 0 0 1 1 1 0 KH domain Utp13 PF08625.11 VDK88663.1 - 5.2e-37 126.9 2.8 7.7e-37 126.4 2.8 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 VDK88663.1 - 5.2e-27 93.6 18.3 4e-05 24.3 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat Nucleoporin_N PF08801.11 VDK88663.1 - 0.00022 20.1 2.6 0.23 10.1 0.2 3.0 1 1 1 2 2 2 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 VDK88663.1 - 0.0048 17.2 0.6 3 8.2 0.1 3.9 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain UTP15_C PF09384.10 VDK88663.1 - 0.0055 16.4 0.6 0.0089 15.7 0.6 1.3 1 0 0 1 1 1 1 UTP15 C terminal ComA PF02679.15 VDK88663.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) gag_pre-integrs PF13976.6 VDK88663.1 - 1.6 8.7 3.6 32 4.5 0.1 3.4 3 0 0 3 3 3 0 GAG-pre-integrase domain Got1 PF04178.12 VDK88669.1 - 1.9e-19 70.2 7.8 3.1e-19 69.4 7.8 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family Oxidored_q4 PF00507.19 VDK88669.1 - 0.027 14.6 0.4 0.058 13.6 0.4 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 EF-hand_1 PF00036.32 VDK88670.1 - 1.2e-31 105.9 9.7 1.7e-10 39.6 0.1 3.1 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 VDK88670.1 - 1.4e-28 98.5 8.8 1.6e-12 47.0 2.2 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 VDK88670.1 - 1.7e-27 95.7 3.9 1.5e-18 67.0 1.8 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 VDK88670.1 - 3.9e-21 73.1 3.5 2.4e-09 36.4 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 VDK88670.1 - 2.1e-17 61.7 3.9 2.5e-06 26.7 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 VDK88670.1 - 4e-09 36.7 0.6 0.00071 19.9 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 VDK88670.1 - 4e-08 33.1 2.3 0.0023 17.8 0.4 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 VDK88670.1 - 0.0001 22.2 1.4 0.36 10.9 0.0 3.3 3 1 0 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 VDK88670.1 - 0.00022 21.2 1.3 0.00032 20.7 0.5 1.7 1 1 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 VDK88670.1 - 0.00066 20.5 0.1 0.0033 18.3 0.1 1.8 1 1 1 2 2 2 1 EF-hand domain DUF4891 PF16232.5 VDK88670.1 - 0.01 16.3 0.0 2.2 8.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4891) Dockerin_1 PF00404.18 VDK88670.1 - 0.01 16.0 0.2 0.35 11.1 0.1 2.4 1 1 1 2 2 2 0 Dockerin type I domain PMBR PF09373.10 VDK88670.1 - 0.013 15.7 0.0 46 4.4 0.0 3.8 4 0 0 4 4 4 0 Pseudomurein-binding repeat p25-alpha PF05517.12 VDK88670.1 - 0.018 15.2 0.1 5.2 7.2 0.0 2.4 1 1 1 2 2 2 0 p25-alpha SPARC_Ca_bdg PF10591.9 VDK88670.1 - 0.041 14.2 0.2 0.6 10.5 0.0 2.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Got1 PF04178.12 VDK88676.1 - 1.9e-19 70.2 7.8 3.1e-19 69.4 7.8 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family Oxidored_q4 PF00507.19 VDK88676.1 - 0.027 14.6 0.4 0.058 13.6 0.4 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 EF-hand_1 PF00036.32 VDK88677.1 - 1.2e-31 105.9 9.7 1.7e-10 39.6 0.1 3.1 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 VDK88677.1 - 1.4e-28 98.5 8.8 1.6e-12 47.0 2.2 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 VDK88677.1 - 1.7e-27 95.7 3.9 1.5e-18 67.0 1.8 2.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 VDK88677.1 - 3.9e-21 73.1 3.5 2.4e-09 36.4 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 VDK88677.1 - 2.1e-17 61.7 3.9 2.5e-06 26.7 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 VDK88677.1 - 4e-09 36.7 0.6 0.00071 19.9 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 VDK88677.1 - 4e-08 33.1 2.3 0.0023 17.8 0.4 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 VDK88677.1 - 0.0001 22.2 1.4 0.36 10.9 0.0 3.3 3 1 0 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 VDK88677.1 - 0.00022 21.2 1.3 0.00032 20.7 0.5 1.7 1 1 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 VDK88677.1 - 0.00066 20.5 0.1 0.0033 18.3 0.1 1.8 1 1 1 2 2 2 1 EF-hand domain DUF4891 PF16232.5 VDK88677.1 - 0.01 16.3 0.0 2.2 8.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4891) Dockerin_1 PF00404.18 VDK88677.1 - 0.01 16.0 0.2 0.35 11.1 0.1 2.4 1 1 1 2 2 2 0 Dockerin type I domain PMBR PF09373.10 VDK88677.1 - 0.013 15.7 0.0 46 4.4 0.0 3.8 4 0 0 4 4 4 0 Pseudomurein-binding repeat p25-alpha PF05517.12 VDK88677.1 - 0.018 15.2 0.1 5.2 7.2 0.0 2.4 1 1 1 2 2 2 0 p25-alpha SPARC_Ca_bdg PF10591.9 VDK88677.1 - 0.041 14.2 0.2 0.6 10.5 0.0 2.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RabGAP-TBC PF00566.18 VDK88683.1 - 2.2e-18 66.7 0.3 2.2e-18 66.7 0.3 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Picorna_P3A PF06363.11 VDK88684.1 - 0.022 14.6 0.7 0.082 12.8 0.7 2.0 1 0 0 1 1 1 0 Picornaviridae P3A protein SRP_TPR_like PF17004.5 VDK88685.1 - 5.5e-24 84.4 11.7 2.9e-20 72.4 2.0 4.4 3 1 0 4 4 4 3 Putative TPR-like repeat SRP72 PF08492.12 VDK88685.1 - 3.8e-17 62.4 9.3 3.8e-17 62.4 9.3 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_2 PF07719.17 VDK88685.1 - 4.5e-12 45.1 19.3 0.075 13.2 0.0 9.3 9 1 1 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 VDK88685.1 - 6.7e-11 42.5 24.1 0.056 14.0 0.0 7.7 4 2 3 8 8 8 6 Tetratricopeptide repeat TPR_6 PF13174.6 VDK88685.1 - 1.5e-10 41.0 14.0 1 10.2 0.1 8.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 VDK88685.1 - 2.6e-10 40.4 19.8 0.94 9.8 0.2 8.3 6 2 2 8 8 8 5 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK88685.1 - 8.6e-09 35.5 19.9 0.045 14.0 2.0 6.2 6 1 1 7 7 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 VDK88685.1 - 3.5e-08 33.0 8.8 0.00059 19.8 0.0 7.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 VDK88685.1 - 3.2e-07 30.6 14.0 0.47 11.4 0.0 9.1 6 4 3 10 10 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 VDK88685.1 - 3.9e-07 30.6 4.8 4.1 8.1 0.0 6.9 5 2 4 9 9 9 2 Tetratricopeptide repeat NARP1 PF12569.8 VDK88685.1 - 1.9e-06 27.1 16.7 0.089 11.7 1.9 4.8 2 2 2 4 4 4 4 NMDA receptor-regulated protein 1 TPR_1 PF00515.28 VDK88685.1 - 2.7e-05 23.8 12.0 1.6 8.6 0.0 7.2 8 0 0 8 8 7 1 Tetratricopeptide repeat SPO22 PF08631.10 VDK88685.1 - 0.00092 18.8 16.0 0.048 13.1 0.1 3.8 2 2 2 5 5 5 2 Meiosis protein SPO22/ZIP4 like TPR_11 PF13414.6 VDK88685.1 - 0.003 17.2 8.2 6.5 6.5 0.0 6.2 7 0 0 7 7 7 1 TPR repeat BTAD PF03704.17 VDK88685.1 - 0.0062 17.0 13.5 0.11 13.0 0.1 4.6 3 2 1 4 4 4 1 Bacterial transcriptional activator domain TPR_9 PF13371.6 VDK88685.1 - 0.008 16.3 6.0 2.7 8.2 0.0 5.5 4 2 2 6 6 5 1 Tetratricopeptide repeat YfdX PF10938.8 VDK88685.1 - 0.0086 16.0 4.3 1 9.3 1.7 3.3 2 1 0 2 2 2 1 YfdX protein TPR_7 PF13176.6 VDK88685.1 - 0.011 15.7 6.0 1.3 9.2 0.0 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat HEAT_2 PF13646.6 VDK88685.1 - 0.21 12.0 4.5 0.87 10.0 0.1 3.4 3 1 2 5 5 5 0 HEAT repeats HrpB1_HrpK PF09613.10 VDK88685.1 - 0.26 10.9 6.3 16 5.1 0.1 4.7 3 2 3 6 6 6 0 Bacterial type III secretion protein (HrpB1_HrpK) Ribosomal_L22 PF00237.19 VDK88685.1 - 0.31 11.3 3.6 1.2 9.4 0.3 3.1 3 0 0 3 3 3 0 Ribosomal protein L22p/L17e TPR_10 PF13374.6 VDK88685.1 - 1.7 8.6 5.8 31 4.6 0.0 5.3 7 0 0 7 7 6 0 Tetratricopeptide repeat PknG_TPR PF16918.5 VDK88685.1 - 2.3 6.8 10.1 0.3 9.7 0.6 3.5 2 1 1 4 4 4 0 Protein kinase G tetratricopeptide repeat HTH_Tnp_Tc5 PF03221.16 VDK88692.1 - 2e-10 40.5 0.0 3.6e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain BrkDBD PF09607.10 VDK88692.1 - 6e-05 22.7 0.2 0.00021 21.0 0.2 1.9 1 1 0 1 1 1 1 Brinker DNA-binding domain CENP-B_N PF04218.13 VDK88692.1 - 0.00019 21.0 0.2 0.00059 19.4 0.2 1.9 1 1 0 1 1 1 1 CENP-B N-terminal DNA-binding domain VID27_N PF17748.1 VDK88692.1 - 0.031 14.1 0.1 0.064 13.1 0.1 1.5 1 0 0 1 1 1 0 VID27 N-terminal region YbfN PF13982.6 VDK88692.1 - 0.087 13.1 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 YbfN-like lipoprotein NOA36 PF06524.12 VDK88693.1 - 0.25 10.6 13.8 0.28 10.5 13.8 1.1 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 VDK88693.1 - 3.5 6.7 5.6 3.5 6.7 5.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 VDK88693.1 - 4.2 5.6 11.1 4.3 5.5 11.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 VDK88693.1 - 7.9 4.6 11.9 7.8 4.6 11.9 1.0 1 0 0 1 1 1 0 Nop14-like family Bromo_TP PF07524.13 VDK88695.1 - 0.074 13.1 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated Sugar_tr PF00083.24 VDK88699.1 - 2.1e-29 102.7 21.6 3e-29 102.2 21.6 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDK88699.1 - 2.1e-16 59.8 25.8 3.8e-12 45.8 20.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Mac PF12464.8 VDK88700.1 - 0.031 14.5 0.9 0.074 13.3 0.9 1.7 1 0 0 1 1 1 0 Maltose acetyltransferase PPR_long PF17177.4 VDK88700.1 - 0.032 13.6 1.4 0.045 13.1 1.4 1.1 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP NPIP PF06409.11 VDK88700.1 - 0.15 11.1 8.0 0.17 10.9 8.0 1.1 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Sugar_tr PF00083.24 VDK88700.1 - 0.16 10.8 1.4 0.15 10.9 0.7 1.2 1 1 0 1 1 1 0 Sugar (and other) transporter DUF4820 PF16091.5 VDK88700.1 - 0.72 9.2 5.1 0.99 8.7 5.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Nore1-SARAH PF16517.5 VDK88700.1 - 3.3 7.7 7.4 0.66 9.9 0.4 2.8 2 1 1 3 3 3 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Band_3_cyto PF07565.13 VDK88700.1 - 6.7 6.4 8.3 1.1 9.0 4.4 1.5 1 1 1 2 2 2 0 Band 3 cytoplasmic domain Zip PF02535.22 VDK88701.1 - 4.9e-42 144.3 11.7 5.8e-42 144.1 11.7 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter MpPF26 PF07666.11 VDK88701.1 - 0.018 15.1 1.5 0.018 15.1 1.5 1.7 2 0 0 2 2 2 0 M penetrans paralogue family 26 Cytochrome-c551 PF10643.9 VDK88701.1 - 0.041 13.5 2.4 0.06 12.9 2.4 1.3 1 0 0 1 1 1 0 Photosystem P840 reaction-centre cytochrome c-551 SPC12 PF06645.13 VDK88701.1 - 0.27 11.3 4.7 14 5.8 0.0 2.6 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Phage_holin_5_2 PF16079.5 VDK88701.1 - 0.8 10.1 6.9 2.6 8.4 0.0 3.3 3 1 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V TMEM237 PF15383.6 VDK88704.1 - 1.1e-32 113.1 0.3 1.3e-32 112.8 0.3 1.1 1 0 0 1 1 1 1 Transmembrane protein 237 DUF3169 PF11368.8 VDK88704.1 - 0.022 14.3 0.1 0.28 10.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) PAN_1 PF00024.26 VDK88705.1 - 9.8e-07 28.7 10.3 8e-06 25.7 3.9 2.3 2 1 0 2 2 2 2 PAN domain PAN_4 PF14295.6 VDK88705.1 - 5.1e-06 26.3 12.1 4.6e-05 23.2 5.2 2.6 2 1 0 2 2 2 2 PAN domain PAN_2 PF08276.11 VDK88705.1 - 1.4 9.0 11.8 0.57 10.3 4.9 2.5 2 1 0 2 2 2 0 PAN-like domain B9-C2 PF07162.11 VDK88710.1 - 1.2e-19 71.1 0.0 1.3e-19 71.0 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Clc-like PF07062.12 VDK88711.1 - 4.9e-32 111.1 7.8 3.4e-31 108.4 7.8 2.0 1 1 0 1 1 1 1 Clc-like Claudin_2 PF13903.6 VDK88711.1 - 2.4e-08 34.0 3.9 6.9e-08 32.5 3.9 1.8 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Tetraspanin PF00335.20 VDK88711.1 - 1.5 8.4 5.9 4.6 6.9 2.1 2.8 2 1 1 3 3 3 0 Tetraspanin family Clc-like PF07062.12 VDK88712.1 - 1.3e-63 214.3 12.9 4e-44 150.6 0.7 2.1 1 1 1 2 2 2 2 Clc-like ELH PF02323.15 VDK88712.1 - 0.059 12.7 1.0 7.7 5.8 1.6 2.2 2 0 0 2 2 2 0 Egg-laying hormone precursor CLPTM1 PF05602.12 VDK88717.1 - 3.9e-156 520.4 2.5 4.7e-156 520.1 2.5 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 VDK88717.1 - 0.0086 15.8 6.8 0.14 12.0 1.6 2.6 2 0 0 2 2 2 2 PQ loop repeat FAM176 PF14851.6 VDK88719.1 - 0.005 16.5 2.1 0.0089 15.7 2.1 1.5 1 1 0 1 1 1 1 FAM176 family DNA_pol_phi PF04931.13 VDK88719.1 - 0.065 11.3 4.7 0.079 11.1 4.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF4834 PF16118.5 VDK88719.1 - 0.23 12.5 3.3 2 9.4 3.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) SET PF00856.28 VDK88721.1 - 3.2e-14 53.7 3.8 4.9e-14 53.1 0.3 2.8 2 1 0 2 2 2 1 SET domain PHD PF00628.29 VDK88721.1 - 0.041 13.8 20.6 0.82 9.6 14.3 3.1 2 0 0 2 2 2 0 PHD-finger Peptidase_M1 PF01433.20 VDK88724.1 - 1.7e-10 40.9 0.1 2e-09 37.4 0.1 2.2 1 1 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 VDK88724.1 - 0.0065 16.7 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain HEAT_2 PF13646.6 VDK88724.1 - 0.054 13.9 0.0 5.4 7.5 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats Frizzled PF01534.17 VDK88725.1 - 1.5e-31 109.6 10.0 2.2e-31 109.1 10.0 1.2 1 0 0 1 1 1 1 Frizzled/Smoothened family membrane region Fz PF01392.22 VDK88725.1 - 4.2e-21 75.6 0.2 4.2e-21 75.6 0.2 2.5 2 1 0 2 2 2 1 Fz domain 7tm_2 PF00002.24 VDK88725.1 - 0.056 12.7 10.7 0.098 11.9 10.7 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) DUF3361 PF11841.8 VDK88727.1 - 3.7e-36 124.4 0.8 3.7e-36 124.4 0.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) PH_12 PF16457.5 VDK88727.1 - 5.3e-19 69.1 0.0 1.1e-18 68.0 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain ELMO_CED12 PF04727.13 VDK88727.1 - 1.7e-14 54.3 0.2 5.3e-14 52.7 0.0 1.9 2 0 0 2 2 2 1 ELMO/CED-12 family SIL1 PF16782.5 VDK88727.1 - 0.12 11.6 3.7 0.032 13.5 0.5 1.6 2 0 0 2 2 2 0 Nucleotide exchange factor SIL1 Hexokinase_2 PF03727.16 VDK88731.1 - 4.9e-25 88.3 0.8 4.3e-21 75.5 0.0 2.0 1 1 1 2 2 2 2 Hexokinase HlyU PF10115.9 VDK88731.1 - 0.15 12.2 0.0 6.1 7.0 0.0 2.2 2 0 0 2 2 2 0 Transcriptional activator HlyU TPP_enzyme_N PF02776.18 VDK88734.1 - 2.4e-47 160.7 2.3 4.3e-47 159.9 2.3 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 VDK88734.1 - 2.5e-24 85.8 0.1 5.2e-22 78.3 0.0 2.6 2 1 0 2 2 2 2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 VDK88734.1 - 1.3e-15 57.3 0.1 4.2e-15 55.7 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain PduV-EutP PF10662.9 VDK88734.1 - 0.099 12.4 0.0 0.53 10.0 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PL48 PF15903.5 VDK88735.1 - 1.3e-31 109.8 0.0 2.6e-31 108.9 0.0 1.5 1 0 0 1 1 1 1 Filopodia upregulated, FAM65 HEAT_2 PF13646.6 VDK88735.1 - 1.1e-08 35.3 0.0 1.7e-06 28.3 0.0 2.5 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 VDK88735.1 - 0.047 14.0 0.1 13 6.4 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat HEAT_EZ PF13513.6 VDK88735.1 - 0.13 12.8 0.1 1.8 9.1 0.0 2.7 3 0 0 3 3 3 0 HEAT-like repeat TPR_11 PF13414.6 VDK88739.1 - 9e-05 22.1 0.1 0.7 9.6 0.0 3.4 3 0 0 3 3 3 2 TPR repeat TPR_14 PF13428.6 VDK88739.1 - 0.00079 20.0 0.8 1.1 10.2 0.0 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK88739.1 - 0.0084 16.4 1.6 0.16 12.3 0.2 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK88739.1 - 0.0084 16.1 9.0 0.3 11.3 0.5 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 VDK88739.1 - 0.017 15.8 0.2 47 4.8 0.2 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 VDK88739.1 - 0.023 14.7 0.4 0.4 10.8 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDK88739.1 - 0.031 14.1 9.2 1.5 8.8 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 VDK88739.1 - 0.043 14.3 0.1 0.33 11.5 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 VDK88739.1 - 0.18 11.9 3.8 5.5 7.1 0.1 3.0 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain MIF4G_like_2 PF09090.11 VDK88740.1 - 6e-42 144.0 9.0 6e-42 144.0 9.0 1.9 2 0 0 2 2 2 1 MIF4G like MIF4G_like PF09088.11 VDK88740.1 - 4.3e-34 118.0 0.7 4.3e-34 118.0 0.7 2.7 2 1 0 2 2 2 1 MIF4G like MIF4G PF02854.19 VDK88740.1 - 2.5e-17 63.2 2.7 8e-17 61.6 0.7 2.7 2 1 0 2 2 2 1 MIF4G domain HGD-D PF06050.13 VDK88740.1 - 0.03 14.1 0.3 0.071 12.9 0.3 1.7 1 0 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Cnd2 PF05786.14 VDK88743.1 - 8.7e-08 31.3 0.1 8.7e-08 31.3 0.1 3.4 3 1 1 4 4 4 2 Condensin complex subunit 2 TSP_1 PF00090.19 VDK88750.1 - 5.2e-12 45.8 24.4 8e-06 26.0 9.1 2.8 2 2 0 2 2 2 2 Thrombospondin type 1 domain TSP_1 PF00090.19 VDK88751.1 - 3.2e-13 49.7 61.0 0.00023 21.3 1.9 7.4 6 2 0 6 6 6 4 Thrombospondin type 1 domain I-set PF07679.16 VDK88751.1 - 6.9e-10 38.9 0.0 1.9e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDK88751.1 - 2.2e-09 37.8 0.0 1.1e-08 35.6 0.0 2.2 1 1 1 2 2 2 1 Immunoglobulin domain ig PF00047.25 VDK88751.1 - 7.9e-07 29.2 1.0 3.4e-06 27.1 0.0 2.6 3 0 0 3 3 3 1 Immunoglobulin domain Ig_2 PF13895.6 VDK88751.1 - 0.00012 22.4 0.0 0.00051 20.3 0.0 2.1 1 0 0 1 1 1 1 Immunoglobulin domain Ig_5 PF16681.5 VDK88751.1 - 0.0002 21.7 0.0 0.00085 19.7 0.0 2.1 1 0 0 1 1 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain V-set PF07686.17 VDK88751.1 - 0.005 17.0 0.0 0.18 12.0 0.0 2.7 1 1 1 2 2 2 1 Immunoglobulin V-set domain Forkhead PF00250.18 VDK88753.1 - 4.3e-30 103.8 0.5 9.2e-30 102.8 0.5 1.5 1 0 0 1 1 1 1 Forkhead domain MAD PF05557.13 VDK88753.1 - 0.17 10.2 0.0 0.25 9.7 0.0 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Ets PF00178.22 VDK88754.1 - 5.8e-36 122.8 0.4 5.8e-36 122.8 0.4 1.7 2 0 0 2 2 2 1 Ets-domain CaMBD PF02888.16 VDK88757.1 - 3.9e-30 103.9 2.7 9.5e-30 102.6 2.7 1.7 1 0 0 1 1 1 1 Calmodulin binding domain SK_channel PF03530.14 VDK88757.1 - 1.2e-27 96.2 3.3 2.5e-27 95.1 2.6 2.0 2 0 0 2 2 2 1 Calcium-activated SK potassium channel Ion_trans_2 PF07885.16 VDK88757.1 - 4.8e-13 48.9 0.1 4.8e-13 48.9 0.1 1.7 2 0 0 2 2 2 1 Ion channel Ion_trans PF00520.31 VDK88757.1 - 0.025 13.8 9.8 0.32 10.2 9.8 2.1 1 1 0 1 1 1 0 Ion transport protein DHC_N2 PF08393.13 VDK88758.1 - 2.7e-22 79.4 1.4 2.7e-22 79.4 1.4 4.3 4 1 2 6 6 6 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 VDK88758.1 - 5.1e-19 68.3 1.0 5.1e-19 68.3 1.0 3.5 1 1 2 3 3 3 1 Dynein heavy chain, N-terminal region 1 RasGAP_C PF03836.15 VDK88758.1 - 6.6 6.9 7.5 2.1 8.5 0.2 3.5 4 0 0 4 4 4 0 RasGAP C-terminus DUF1152 PF06626.12 VDK88759.1 - 0.019 14.2 0.2 0.028 13.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) QSregVF_b PF12843.7 VDK88759.1 - 0.057 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative quorum-sensing-regulated virulence factor F-box PF00646.33 VDK88764.1 - 0.0068 16.3 0.0 0.022 14.6 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ank_2 PF12796.7 VDK88765.1 - 3.6e-25 88.3 0.3 1.8e-06 28.5 0.0 5.8 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDK88765.1 - 4e-19 68.4 1.5 0.013 15.8 0.1 7.2 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK88765.1 - 4.2e-15 54.3 3.9 0.27 11.9 0.0 9.0 10 0 0 10 10 10 4 Ankyrin repeat Ank_4 PF13637.6 VDK88765.1 - 2.8e-14 53.3 2.2 0.04 14.5 0.0 6.7 6 1 0 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 VDK88765.1 - 2.6e-10 40.3 13.2 0.2 12.2 0.2 7.7 8 1 0 8 8 8 4 Ankyrin repeat SOCS_box PF07525.16 VDK88765.1 - 2.7e-10 40.4 2.6 5.9e-10 39.3 2.6 1.6 1 0 0 1 1 1 1 SOCS box Btz PF09405.10 VDK88770.1 - 6.9e-09 36.1 3.3 6.9e-09 36.1 3.3 2.2 3 0 0 3 3 3 1 CASC3/Barentsz eIF4AIII binding Carb_anhydrase PF00194.21 VDK88771.1 - 2.2e-70 237.1 0.0 2.8e-70 236.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Aa_trans PF01490.18 VDK88774.1 - 5.8e-69 232.8 20.1 8.6e-69 232.2 20.1 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_permease PF03845.13 VDK88774.1 - 0.96 8.2 20.4 0.065 12.1 1.3 3.4 3 0 0 3 3 3 0 Spore germination protein Phage_holin_3_6 PF07332.11 VDK88774.1 - 5.3 7.1 11.9 1.8 8.6 1.5 4.0 4 1 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Motile_Sperm PF00635.26 VDK88775.1 - 0.077 12.9 0.0 0.24 11.3 0.0 1.9 2 1 0 2 2 2 0 MSP (Major sperm protein) domain FeoB_Cyto PF17910.1 VDK88775.1 - 0.13 12.8 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 FeoB cytosolic helical domain Arm_vescicular PF18770.1 VDK88775.1 - 0.97 9.4 4.2 8.9 6.3 0.9 2.6 2 0 0 2 2 2 0 Armadillo tether-repeat of vescicular transport factor Glycos_transf_2 PF00535.26 VDK88776.1 - 1.3e-21 77.2 0.0 1.8e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 VDK88776.1 - 1e-09 38.6 0.0 1.5e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 VDK88776.1 - 5.3e-05 22.8 0.0 8.3e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 VDK88776.1 - 0.052 14.1 0.0 0.12 12.9 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferase family 2 Med2 PF11214.8 VDK88778.1 - 0.031 14.4 0.0 0.24 11.6 0.0 2.5 2 0 0 2 2 2 0 Mediator complex subunit 2 VAPB_antitox PF02697.14 VDK88778.1 - 0.06 14.1 0.0 0.25 12.1 0.0 2.1 1 0 0 1 1 1 0 Putative antitoxin DUF4506 PF14958.6 VDK88778.1 - 0.061 12.8 0.2 8.6 5.9 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4506) CHD5 PF04420.14 VDK88779.1 - 5.6e-10 39.3 0.4 7.3e-10 38.9 0.4 1.1 1 0 0 1 1 1 1 CHD5-like protein DUF4515 PF14988.6 VDK88779.1 - 0.033 14.0 0.1 0.044 13.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) PhoR PF11808.8 VDK88779.1 - 0.34 11.3 0.1 0.34 11.3 0.1 2.3 3 0 0 3 3 3 0 Phosphate regulon sensor protein PhoR HECT PF00632.25 VDK88781.1 - 8.4e-60 202.8 0.0 1.4e-59 202.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) PABP PF00658.18 VDK88781.1 - 1.7e-15 56.9 0.0 4.4e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RETICULATA-like PF11891.8 VDK88781.1 - 0.012 15.4 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 Protein RETICULATA-related Spore_III_AF PF09581.10 VDK88781.1 - 0.41 10.7 3.0 14 5.6 0.0 3.0 3 0 0 3 3 3 0 Stage III sporulation protein AF (Spore_III_AF) PDZ PF00595.24 VDK88785.1 - 1.5e-34 118.2 2.6 2.7e-13 50.1 0.0 3.9 4 0 0 4 4 4 3 PDZ domain PDZ_6 PF17820.1 VDK88785.1 - 1.1e-10 41.2 0.9 0.00057 19.7 0.1 4.2 4 0 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 VDK88785.1 - 4.9e-06 26.8 0.6 0.57 10.5 0.0 4.0 4 0 0 4 4 4 2 PDZ domain Ser_hydrolase PF06821.13 VDK88785.1 - 0.11 12.3 0.3 0.45 10.3 0.3 2.0 1 1 0 1 1 1 0 Serine hydrolase VWD PF00094.25 VDK88786.1 - 5.8e-11 42.9 0.0 4.1e-10 40.2 0.0 2.7 1 0 0 1 1 1 1 von Willebrand factor type D domain BAR_3 PF16746.5 VDK88786.1 - 0.00033 20.4 4.0 0.00071 19.4 4.0 1.5 1 0 0 1 1 1 1 BAR domain of APPL family C8 PF08742.11 VDK88786.1 - 0.0055 17.1 4.3 0.013 15.9 4.3 1.6 1 0 0 1 1 1 1 C8 domain RecG_N PF17190.4 VDK88786.1 - 0.027 15.2 3.5 1 10.2 1.6 3.9 2 1 1 3 3 3 0 RecG N-terminal helical domain AAA_11 PF13086.6 VDK88786.1 - 0.15 11.8 0.9 0.46 10.2 0.9 1.8 1 0 0 1 1 1 0 AAA domain OmpH PF03938.14 VDK88786.1 - 0.31 11.4 5.2 0.15 12.4 0.5 2.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Apolipoprotein PF01442.18 VDK88786.1 - 0.7 9.7 6.2 2 8.3 0.3 2.4 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain FRB_dom PF08771.11 VDK88786.1 - 9 6.8 6.5 20 5.7 0.7 3.4 3 1 1 4 4 4 0 FKBP12-rapamycin binding domain SH3_1 PF00018.28 VDK88794.1 - 5.6e-11 41.9 0.0 9.6e-11 41.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK88794.1 - 2.8e-10 39.9 0.0 5.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 VDK88794.1 - 3.7e-09 36.7 0.1 3.7e-09 36.7 0.1 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 VDK88794.1 - 5.5e-09 35.6 0.0 1e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 VDK88794.1 - 0.065 13.3 0.0 0.21 11.7 0.0 1.9 1 0 0 1 1 1 0 SH3 domain GARP PF16731.5 VDK88794.1 - 0.35 10.5 5.9 0.096 12.4 1.2 2.3 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Fil_haemagg PF05594.14 VDK88794.1 - 1.1 9.9 7.4 2.5 8.7 7.4 1.5 1 0 0 1 1 1 0 Haemagluttinin repeat NUDIX PF00293.28 VDK88798.1 - 1.2e-16 60.9 0.1 1.6e-16 60.6 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain BLOC1S3 PF15753.5 VDK88799.1 - 3.4e-11 43.6 0.9 4.2e-11 43.3 0.9 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex 1 subunit 3 BAR_3_WASP_bdg PF10456.9 VDK88799.1 - 0.03 13.8 0.1 0.039 13.4 0.1 1.2 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein WXG100 PF06013.12 VDK88799.1 - 0.03 14.5 1.2 0.04 14.2 0.2 1.7 2 0 0 2 2 2 0 Proteins of 100 residues with WXG HIP1_clath_bdg PF16515.5 VDK88799.1 - 0.21 12.2 3.2 0.63 10.7 3.2 1.8 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF711 PF05167.12 VDK88800.1 - 0.49 9.2 5.0 0.3 10.0 3.0 1.5 2 0 0 2 2 2 0 Uncharacterised ACR (DUF711) SNAPc_SNAP43 PF09808.9 VDK88803.1 - 4e-40 137.8 1.8 4.9e-40 137.5 1.8 1.0 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 Voltage_CLC PF00654.20 VDK88804.1 - 2.9e-95 319.5 20.8 1.8e-94 316.9 18.5 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 VDK88804.1 - 8.6e-15 54.9 0.3 1.5e-08 35.0 0.1 2.5 2 0 0 2 2 2 2 CBS domain N1221 PF07923.13 VDK88806.1 - 2.8e-19 69.4 0.4 4.5e-19 68.7 0.4 1.3 1 0 0 1 1 1 1 N1221-like protein NifW PF03206.14 VDK88806.1 - 0.074 13.6 0.0 2.6 8.6 0.0 2.5 1 1 1 2 2 2 0 Nitrogen fixation protein NifW PAN_1 PF00024.26 VDK88808.1 - 8.2e-42 141.1 33.6 7.3e-10 38.7 0.4 6.4 6 0 0 6 6 6 5 PAN domain PAN_4 PF14295.6 VDK88808.1 - 1.4 8.9 18.1 1.1 9.3 0.7 5.2 5 0 0 5 5 5 0 PAN domain WD40 PF00400.32 VDK88809.1 - 1.4e-08 35.2 0.7 0.13 13.2 0.0 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat TLE_N PF03920.15 VDK88812.1 - 2.5e-49 166.7 13.3 3.4e-49 166.2 13.3 1.1 1 0 0 1 1 1 1 Groucho/TLE N-terminal Q-rich domain APG17 PF04108.12 VDK88812.1 - 0.0041 16.3 3.6 0.0049 16.0 3.6 1.2 1 0 0 1 1 1 1 Autophagy protein Apg17 ZapD PF07072.11 VDK88812.1 - 0.16 11.7 5.1 3.2 7.4 1.5 2.1 2 0 0 2 2 2 0 Cell division protein PIN_4 PF13638.6 VDK88813.1 - 0.077 13.3 1.0 0.14 12.4 0.1 2.0 2 0 0 2 2 2 0 PIN domain Ring_hydroxyl_A PF00848.19 VDK88813.1 - 0.085 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) GIY-YIG PF01541.24 VDK88817.1 - 5.2e-14 52.3 0.0 1e-13 51.3 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-RING_2 PF13639.6 VDK88817.1 - 0.0016 18.8 5.0 0.0059 16.9 5.0 2.1 1 0 0 1 1 1 1 Ring finger domain PHD PF00628.29 VDK88817.1 - 0.0018 18.2 5.1 0.014 15.3 3.4 2.5 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 VDK88817.1 - 0.013 15.3 1.4 0.013 15.3 1.4 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-HC5HC2H_2 PF13832.6 VDK88817.1 - 0.027 14.6 1.5 0.06 13.5 0.8 2.0 2 0 0 2 2 2 0 PHD-zinc-finger like domain T5orf172 PF10544.9 VDK88817.1 - 0.032 14.8 0.0 0.061 13.9 0.0 1.5 1 0 0 1 1 1 0 T5orf172 domain zf-HC5HC2H PF13771.6 VDK88817.1 - 0.08 13.2 4.8 0.047 13.9 2.1 2.1 2 0 0 2 2 2 0 PHD-like zinc-binding domain FANCL_C PF11793.8 VDK88817.1 - 0.25 11.5 5.3 5 7.4 5.4 2.5 1 1 1 2 2 2 0 FANCL C-terminal domain Nckap1 PF09735.9 VDK88818.1 - 0 1373.5 35.9 2.1e-207 691.7 13.3 2.0 1 1 1 2 2 2 2 Membrane-associated apoptosis protein PID PF00640.23 VDK88819.1 - 1.8e-05 24.8 0.1 2.1e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) ICAP-1_inte_bdg PF10480.9 VDK88819.1 - 2.6e-05 24.3 0.1 3.2e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Beta-1 integrin binding protein PTB PF08416.13 VDK88819.1 - 0.0038 17.4 0.1 0.0049 17.0 0.1 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SmAKAP PF15127.6 VDK88825.1 - 0.18 13.1 2.0 2.3 9.4 0.0 3.5 3 0 0 3 3 3 0 Small membrane A-kinase anchor protein Gemin6 PF06372.12 VDK88826.1 - 2.5e-17 62.9 0.1 3.8e-17 62.3 0.1 1.3 1 1 0 1 1 1 1 Gemin6 protein DUF4224 PF13986.6 VDK88826.1 - 0.0093 15.8 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4224) Peptidase_C1 PF00112.23 VDK88827.1 - 4.3e-71 239.5 0.2 4.3e-71 239.5 0.2 1.5 2 0 0 2 2 2 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 VDK88827.1 - 5.6e-09 36.3 2.7 1.2e-08 35.3 2.7 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Ndr PF03096.14 VDK88827.1 - 0.28 9.9 1.0 0.41 9.3 1.0 1.2 1 0 0 1 1 1 0 Ndr family HTH_44 PF14641.6 VDK88829.1 - 0.087 13.3 0.4 0.17 12.3 0.4 1.6 1 1 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 Pkinase_Tyr PF07714.17 VDK88835.1 - 6.7e-72 241.9 0.0 1.2e-71 241.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK88835.1 - 3.3e-41 141.4 0.0 1.3e-40 139.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK88835.1 - 1.1e-10 41.4 0.1 2.7e-10 40.2 0.1 1.7 1 0 0 1 1 1 1 SH2 domain DNTTIP1_dimer PF18192.1 VDK88837.1 - 3.6e-20 72.1 0.0 8.6e-20 70.9 0.0 1.7 1 0 0 1 1 1 1 DNTTIP1 dimerisation domain PORR PF11955.8 VDK88837.1 - 0.0018 17.3 0.1 0.073 12.0 0.0 2.1 2 0 0 2 2 2 2 Plant organelle RNA recognition domain AT_hook PF02178.19 VDK88837.1 - 0.044 13.7 5.2 0.1 12.5 5.2 1.7 1 0 0 1 1 1 0 AT hook motif MarR PF01047.22 VDK88842.1 - 0.0024 17.7 0.2 1.1 9.2 0.0 3.9 4 0 0 4 4 4 1 MarR family TMEM52 PF14979.6 VDK88842.1 - 0.031 14.2 0.1 0.089 12.7 0.1 1.8 1 0 0 1 1 1 0 Transmembrane 52 B-block_TFIIIC PF04182.12 VDK88842.1 - 0.72 10.0 4.0 4.5 7.5 0.1 3.8 5 0 0 5 5 5 0 B-block binding subunit of TFIIIC SPRY PF00622.28 VDK88843.1 - 1.1e-18 67.5 0.0 1.9e-18 66.7 0.0 1.4 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 VDK88843.1 - 5.3e-10 39.0 9.5 1.1e-09 37.9 9.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK88843.1 - 2.4e-05 24.1 10.6 5e-05 23.1 10.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Slx4 PF09494.10 VDK88843.1 - 0.043 13.8 0.2 0.31 11.0 0.0 2.4 2 0 0 2 2 2 0 Slx4 endonuclease RNA_pol_A_bac PF01000.26 VDK88847.1 - 4.3e-37 126.9 0.1 7.6e-37 126.1 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 VDK88847.1 - 1.3e-19 69.3 0.0 2e-19 68.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain TM231 PF10149.9 VDK88848.1 - 9e-67 225.5 3.8 1e-66 225.4 3.8 1.0 1 0 0 1 1 1 1 Transmembrane protein 231 zf-CDGSH PF09360.10 VDK88850.1 - 9.8e-19 67.3 2.7 1.3e-08 34.9 0.2 2.4 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type Molybdopterin_N PF18364.1 VDK88850.1 - 0.064 13.3 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin oxidoreductase N-terminal domain BTB PF00651.31 VDK88851.1 - 1.1e-31 109.3 0.9 2.6e-31 108.1 0.9 1.7 1 0 0 1 1 1 1 BTB/POZ domain MATH PF00917.26 VDK88851.1 - 2.5e-06 27.6 0.3 6e-06 26.4 0.3 1.7 1 0 0 1 1 1 1 MATH domain BACK PF07707.15 VDK88851.1 - 0.002 18.2 1.3 0.13 12.4 0.0 3.3 3 0 0 3 3 3 1 BTB And C-terminal Kelch Herpes_capsid PF06112.11 VDK88851.1 - 4.8 7.2 10.1 8.4 6.4 10.1 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein YccV-like PF08755.11 VDK88852.1 - 1.4e-25 89.6 0.1 2.4e-25 88.9 0.1 1.4 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Fcf1 PF04900.12 VDK88853.1 - 0.05 14.0 0.5 0.15 12.4 0.1 2.0 2 0 0 2 2 2 0 Fcf1 DUF1751 PF08551.10 VDK88856.1 - 7.1e-10 39.3 10.5 3.2e-06 27.6 2.6 2.6 1 1 1 2 2 2 2 Eukaryotic integral membrane protein (DUF1751) Pox_MCEL PF03291.16 VDK88856.1 - 0.068 12.3 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 mRNA capping enzyme Choline_kinase PF01633.20 VDK88858.1 - 1.6e-32 112.9 0.1 1.4e-29 103.2 0.1 2.2 1 1 0 1 1 1 1 Choline/ethanolamine kinase SelP_N PF04592.14 VDK88864.1 - 3.3 7.1 13.3 4.2 6.7 13.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zona_pellucida PF00100.23 VDK88866.1 - 6.5e-05 22.9 0.0 9.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Zona pellucida-like domain Methyltransf_23 PF13489.6 VDK88867.1 - 8.3e-16 58.3 0.0 1.6e-15 57.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDK88867.1 - 7.9e-15 55.3 0.0 2.2e-14 53.9 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDK88867.1 - 8.7e-15 55.3 0.0 3.1e-14 53.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDK88867.1 - 3.9e-11 43.0 0.0 6.3e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDK88867.1 - 5.7e-10 39.7 0.0 4.5e-09 36.8 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain CheR PF01739.18 VDK88867.1 - 2.5e-07 30.4 0.4 0.00037 20.0 0.1 2.5 3 0 0 3 3 3 2 CheR methyltransferase, SAM binding domain Ubie_methyltran PF01209.18 VDK88867.1 - 7.3e-06 25.5 0.0 1.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 VDK88867.1 - 2.7e-05 23.5 0.2 0.0018 17.5 0.0 2.3 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family MTS PF05175.14 VDK88867.1 - 7.8e-05 22.3 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 VDK88867.1 - 0.011 15.1 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB Pox_MCEL PF03291.16 VDK88867.1 - 0.016 14.4 0.0 0.3 10.2 0.0 2.1 2 0 0 2 2 2 0 mRNA capping enzyme Rsm22 PF09243.10 VDK88867.1 - 0.019 14.2 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 CMAS PF02353.20 VDK88867.1 - 0.026 13.8 0.1 0.35 10.1 0.1 2.2 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_28 PF02636.17 VDK88867.1 - 0.06 13.0 0.0 8.5 5.9 0.0 2.5 3 0 0 3 3 3 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_24 PF13578.6 VDK88867.1 - 0.14 13.2 0.0 0.31 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Myelin_PLP PF01275.19 VDK88882.1 - 2.3e-37 129.2 21.5 2.8e-37 128.9 21.5 1.0 1 0 0 1 1 1 1 Myelin proteolipid protein (PLP or lipophilin) DUF2975 PF11188.8 VDK88882.1 - 0.013 15.4 7.3 0.013 15.4 7.3 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF2975) SdpA PF17418.2 VDK88882.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Sporulation delaying protein SdpA Plasmid_stab_B PF10784.9 VDK88882.1 - 0.25 11.2 1.0 0.51 10.2 1.0 1.5 1 0 0 1 1 1 0 Plasmid stability protein DHHC PF01529.20 VDK88882.1 - 3.5 7.7 16.4 0.56 10.3 0.7 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase NPV_P10 PF05531.12 VDK88883.1 - 0.008 16.6 0.1 0.023 15.2 0.0 1.8 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Dishevelled PF02377.15 VDK88883.1 - 0.17 12.3 1.0 0.42 11.1 0.4 1.9 2 0 0 2 2 2 0 Dishevelled specific domain LUC7 PF03194.15 VDK88884.1 - 1.1e-49 169.5 17.1 1.6e-30 106.6 9.6 2.3 2 0 0 2 2 2 2 LUC7 N_terminus COG2 PF06148.11 VDK88884.1 - 0.06 13.4 3.2 0.21 11.7 0.1 2.6 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 TPR_MLP1_2 PF07926.12 VDK88884.1 - 0.089 12.9 6.3 6 6.9 0.4 3.4 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein FlaC_arch PF05377.11 VDK88885.1 - 0.015 15.6 0.5 0.024 15.0 0.5 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) CBM_21 PF03370.13 VDK88886.1 - 1e-26 93.3 0.6 2.5e-26 92.1 0.6 1.6 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 VDK88886.1 - 7.6e-11 42.5 0.1 1.5e-10 41.5 0.1 1.5 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) NapB PF03892.14 VDK88886.1 - 0.13 12.3 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) WD40 PF00400.32 VDK88888.1 - 4e-32 109.7 18.8 3.1e-08 34.1 0.1 11.9 12 0 0 12 12 12 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK88888.1 - 2.5e-16 59.7 10.0 0.35 11.2 0.1 8.5 2 2 5 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 VDK88888.1 - 3.4e-10 39.4 3.2 0.011 14.7 0.1 5.6 3 2 2 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 VDK88888.1 - 2e-08 33.9 9.3 0.017 14.5 0.2 4.0 2 1 1 4 4 4 3 WD40-like domain PQQ_2 PF13360.6 VDK88888.1 - 1.2e-07 31.5 0.0 0.0045 16.6 0.0 2.7 3 0 0 3 3 3 2 PQQ-like domain NUP214 PF16755.5 VDK88888.1 - 0.0089 15.3 0.5 0.19 11.0 0.0 2.5 3 0 0 3 3 3 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Hira PF07569.11 VDK88888.1 - 0.066 12.9 4.1 13 5.4 0.1 5.0 5 0 0 5 5 5 0 TUP1-like enhancer of split Cyclin_N PF00134.23 VDK88890.1 - 4.3e-07 29.7 1.3 9.6e-07 28.6 0.1 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 VDK88890.1 - 0.37 10.9 6.1 1.1 9.4 0.0 3.2 4 0 0 4 4 4 0 Transcription factor TFIIB repeat tRNA-synt_2 PF00152.20 VDK88895.1 - 1.5e-99 333.0 0.0 2.1e-99 332.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 VDK88895.1 - 2.2e-13 50.0 0.2 6.3e-13 48.5 0.1 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Mito_fiss_reg PF05308.11 VDK88895.1 - 0.05 13.7 0.6 0.11 12.6 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator tRNA_anti_2 PF13742.6 VDK88895.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain DUF1565 PF07602.11 VDK88895.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) Glyco_tran_28_C PF04101.16 VDK88897.1 - 1.3e-27 96.8 0.0 1.4e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Homeobox_KN PF05920.11 VDK88899.1 - 6.9e-13 48.3 0.9 1.3e-12 47.4 0.9 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 VDK88899.1 - 0.00015 21.6 1.0 0.00022 21.0 0.1 1.7 2 0 0 2 2 2 1 Homeodomain DUF919 PF06034.11 VDK88902.1 - 0.029 14.2 0.2 0.067 13.0 0.2 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) MADF_DNA_bdg PF10545.9 VDK88902.1 - 0.097 13.0 0.4 0.18 12.2 0.2 1.6 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Neurensin PF14927.6 VDK88904.1 - 2.8e-22 78.9 0.0 3.9e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 Neurensin DUF3040 PF11239.8 VDK88904.1 - 0.0015 18.8 0.8 0.79 10.0 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3040) DUF3185 PF11381.8 VDK88904.1 - 0.0058 16.6 2.1 0.017 15.1 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3185) DUF2065 PF09838.9 VDK88904.1 - 0.29 11.2 5.6 0.72 9.9 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2065) TMEM100 PF16311.5 VDK88904.1 - 1.2 8.7 2.5 4.5 6.9 0.1 2.2 2 0 0 2 2 2 0 Transmembrane protein 100 Cupin_8 PF13621.6 VDK88905.1 - 4e-21 75.9 0.0 7.6e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 VDK88905.1 - 1.2e-08 34.8 0.0 1.9e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 VDK88905.1 - 3.4e-07 30.7 0.1 2.2e-06 28.1 0.0 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase MWFE PF15879.5 VDK88905.1 - 0.00075 19.6 0.1 0.0015 18.6 0.1 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Cupin_2 PF07883.11 VDK88905.1 - 0.0076 15.9 0.0 0.03 14.0 0.0 1.9 2 0 0 2 2 2 1 Cupin domain GPI PF06560.11 VDK88905.1 - 0.022 14.0 0.1 0.041 13.1 0.1 1.4 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Cupin_1 PF00190.22 VDK88905.1 - 0.05 13.2 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 Cupin Arf PF00025.21 VDK88908.1 - 2.3e-39 134.6 0.1 4.2e-39 133.8 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 VDK88908.1 - 5.2e-08 32.4 9.8 7.9e-07 28.6 0.2 3.4 1 1 2 3 3 3 2 G-protein alpha subunit Roc PF08477.13 VDK88908.1 - 1.1e-05 25.7 0.0 3.5e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 VDK88908.1 - 5.9e-05 23.1 0.0 0.00015 21.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Cpn60_TCP1 PF00118.24 VDK88908.1 - 0.015 14.0 0.3 0.021 13.4 0.3 1.2 1 0 0 1 1 1 0 TCP-1/cpn60 chaperonin family AAA_18 PF13238.6 VDK88908.1 - 0.11 13.1 3.4 0.83 10.2 3.4 2.4 1 1 0 1 1 1 0 AAA domain KicB PF03882.14 VDK88908.1 - 0.11 12.7 2.4 0.56 10.4 0.2 2.4 1 1 1 2 2 2 0 MukF winged-helix domain Gti1_Pac2 PF09729.9 VDK88908.1 - 0.26 11.4 4.2 0.32 11.1 2.9 1.8 2 0 0 2 2 2 0 Gti1/Pac2 family Ribosomal_60s PF00428.19 VDK88910.1 - 3.9e-27 94.7 4.1 5.1e-27 94.3 4.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein PT-VENN PF04829.13 VDK88910.1 - 0.038 14.1 4.2 0.081 13.0 4.2 1.5 1 0 0 1 1 1 0 Pre-toxin domain with VENN motif Ribosomal_L27A PF00828.19 VDK88911.1 - 5.8e-24 85.2 0.0 8.1e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A EIF_2_alpha PF07541.12 VDK88913.1 - 4.2e-34 117.1 0.2 3.5e-33 114.1 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 VDK88913.1 - 1.2e-13 51.2 0.6 2.5e-13 50.1 0.6 1.5 1 0 0 1 1 1 1 S1 RNA binding domain DUF4388 PF14332.6 VDK88913.1 - 0.078 13.3 0.0 0.18 12.1 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4388) Pkinase PF00069.25 VDK88916.1 - 1.1e-51 175.8 1.8 2e-51 174.9 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK88916.1 - 6.2e-32 110.9 0.0 6.2e-32 110.9 0.0 2.6 2 1 1 3 3 3 1 Protein tyrosine kinase APH PF01636.23 VDK88916.1 - 0.16 11.9 0.0 0.16 11.9 0.0 3.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family Patched PF02460.18 VDK88918.1 - 1e-70 238.9 23.6 2.6e-40 138.3 0.1 2.0 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK88918.1 - 2.8e-34 118.1 2.8 2.8e-34 118.1 2.8 3.0 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation Ion_trans_2 PF07885.16 VDK88922.1 - 8e-29 99.4 23.5 5.6e-19 67.9 5.9 2.3 2 0 0 2 2 2 2 Ion channel IRK PF01007.20 VDK88922.1 - 0.01 15.6 10.7 0.038 13.8 0.3 3.0 3 1 1 4 4 4 0 Inward rectifier potassium channel transmembrane domain Oxidored_q2 PF00420.24 VDK88922.1 - 0.52 10.0 7.5 7.2 6.3 7.1 2.6 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF4519 PF15012.6 VDK88922.1 - 3.6 7.8 4.8 1.9 8.7 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) DnaJ PF00226.31 VDK88924.1 - 4.3e-24 84.4 0.3 1.3e-23 82.9 0.3 1.9 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 VDK88924.1 - 6.2e-10 39.1 7.5 6.2e-10 39.1 7.5 2.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDK88924.1 - 1.5e-06 28.5 4.1 0.005 17.2 2.3 2.8 2 1 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 VDK88924.1 - 2e-05 25.0 8.7 0.013 16.3 1.0 3.3 3 0 0 3 3 2 2 C2H2-type zinc finger zf-met PF12874.7 VDK88924.1 - 2.2e-05 24.7 4.0 2.2e-05 24.7 4.0 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 VDK88924.1 - 0.00012 22.0 9.2 0.0091 16.0 1.9 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK88924.1 - 0.0099 16.3 13.3 0.018 15.5 0.7 3.2 3 0 0 3 3 2 2 Zinc finger, C2H2 type AKAP95 PF04988.12 VDK88924.1 - 0.012 15.9 9.9 0.012 15.9 9.9 1.8 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) RPT PF13446.6 VDK88924.1 - 0.019 14.9 1.9 0.035 14.0 0.1 2.5 3 0 0 3 3 3 0 A repeated domain in UCH-protein zf-BED PF02892.15 VDK88924.1 - 0.077 13.0 5.5 2.8 8.0 0.1 2.7 2 1 0 2 2 2 0 BED zinc finger zf-FCS PF06467.14 VDK88924.1 - 0.15 12.0 4.1 1.9 8.5 0.1 2.6 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif DUF4187 PF13821.6 VDK88924.1 - 0.36 10.7 3.9 0.31 10.8 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4187) HNH_5 PF14279.6 VDK88924.1 - 5.2 7.0 6.4 6.9 6.6 0.7 2.5 2 0 0 2 2 2 0 HNH endonuclease DnaJ PF00226.31 VDK88926.1 - 1e-22 80.0 1.1 2.5e-22 78.8 1.1 1.7 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 VDK88926.1 - 9.5e-05 22.3 0.0 0.00021 21.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin SHR3_chaperone PF08229.11 VDK88926.1 - 0.16 10.9 0.0 0.29 10.1 0.0 1.3 1 0 0 1 1 1 0 ER membrane protein SH3 zf-B_box PF00643.24 VDK88934.1 - 5.5e-10 39.2 27.0 2.2e-06 27.7 8.3 4.6 4 1 0 4 4 4 2 B-box zinc finger zf-RING_UBOX PF13445.6 VDK88934.1 - 1.2e-07 31.7 9.4 1.2e-07 31.7 9.4 3.6 3 2 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 VDK88934.1 - 1.9e-07 30.9 11.2 1.9e-07 30.9 11.2 3.8 3 1 1 4 4 4 1 zinc-RING finger domain zf-C3HC4 PF00097.25 VDK88934.1 - 4.9e-06 26.3 12.6 4.9e-06 26.3 12.6 3.7 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 VDK88934.1 - 8.5e-06 25.8 13.6 8.5e-06 25.8 13.6 3.9 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 VDK88934.1 - 1.5e-05 25.2 11.9 1.5e-05 25.2 11.9 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK88934.1 - 2.1e-05 24.3 13.1 2.1e-05 24.3 13.1 3.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) NHL PF01436.21 VDK88936.1 - 5e-31 105.2 16.6 1.3e-10 40.7 0.1 6.1 6 0 0 6 6 6 5 NHL repeat DUF5128 PF17170.4 VDK88936.1 - 1.2e-05 24.6 0.3 7.7e-05 22.0 0.1 2.2 2 0 0 2 2 2 1 6-bladed beta-propeller SGL PF08450.12 VDK88936.1 - 1.5e-05 24.7 0.1 0.046 13.3 0.0 3.2 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region CPSF_A PF03178.15 VDK88936.1 - 0.012 14.9 0.1 0.023 14.0 0.1 1.3 1 0 0 1 1 1 0 CPSF A subunit region VCBS PF13517.6 VDK88936.1 - 0.1 13.2 0.8 65 4.2 0.0 3.6 3 1 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella UCH PF00443.29 VDK88939.1 - 1.4e-67 227.9 0.1 2.3e-67 227.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 VDK88939.1 - 6.3e-15 55.6 3.1 6.6e-08 32.5 0.5 3.2 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 VDK88939.1 - 2.6e-09 37.6 0.3 9.7e-09 35.7 0.2 2.0 2 0 0 2 2 2 1 DUSP domain EF-hand_6 PF13405.6 VDK88939.1 - 6.1e-08 32.0 1.5 0.0027 17.5 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 VDK88939.1 - 9.2e-08 31.1 2.3 0.0063 16.0 0.2 3.5 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 VDK88939.1 - 5.1e-07 30.1 1.2 0.047 14.1 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 VDK88939.1 - 1.5e-06 27.9 3.4 0.019 14.8 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK88939.1 - 1.6e-05 24.1 4.4 0.039 13.5 1.0 3.0 2 0 0 2 2 2 2 EF hand Pyridoxal_deC PF00282.19 VDK88944.1 - 1.5e-25 89.7 0.0 2.3e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 VDK88944.1 - 5.2e-10 38.8 0.1 4.7e-09 35.7 0.0 2.2 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 VDK88944.1 - 3.7e-05 23.1 0.0 6.6e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 VDK88944.1 - 0.00089 18.6 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 VDK88944.1 - 0.091 11.3 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Arch_fla_DE PF04659.13 VDK88944.1 - 0.14 12.0 0.1 0.34 10.8 0.1 1.6 1 0 0 1 1 1 0 Archaeal flagella protein Nucleoporin_N PF08801.11 VDK88945.1 - 5.5e-27 94.6 0.0 7.5e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Filament PF00038.21 VDK88948.1 - 0.0049 16.5 1.3 0.007 16.0 1.3 1.1 1 0 0 1 1 1 1 Intermediate filament protein NUDIX-like PF09296.11 VDK88948.1 - 0.018 15.7 0.0 0.081 13.6 0.0 2.0 2 0 0 2 2 2 0 NADH pyrophosphatase-like rudimentary NUDIX domain DUF1640 PF07798.11 VDK88948.1 - 0.42 10.6 5.9 0.62 10.1 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) AA_permease PF00324.21 VDK88951.1 - 0.0015 17.2 3.3 0.005 15.5 2.8 1.8 2 0 0 2 2 2 1 Amino acid permease ATP-synt_G PF04718.15 VDK88960.1 - 6.4e-17 62.2 0.0 7.9e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit TRAP_beta PF05753.14 VDK88961.1 - 2.7e-51 173.5 0.0 3.8e-51 173.0 0.0 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) Astacin PF01400.24 VDK88963.1 - 3.2e-72 242.2 0.0 5.9e-72 241.3 0.0 1.5 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 VDK88963.1 - 1e-07 32.4 12.8 1.1e-07 32.2 8.0 2.6 2 0 0 2 2 2 1 ShK domain-like PLAC PF08686.11 VDK88963.1 - 0.33 11.8 4.9 0.71 10.7 4.9 1.6 1 0 0 1 1 1 0 PLAC (protease and lacunin) domain Crisp PF08562.10 VDK88963.1 - 2.7 8.6 7.9 6 7.5 7.9 1.6 1 0 0 1 1 1 0 Crisp PH_16 PF17838.1 VDK88968.1 - 5.3e-21 74.7 0.1 1e-20 73.8 0.1 1.5 1 0 0 1 1 1 1 PH domain Btz PF09405.10 VDK88972.1 - 3.9e-15 56.3 13.1 3.9e-15 56.3 13.1 4.5 4 2 0 4 4 4 1 CASC3/Barentsz eIF4AIII binding Ntox5 PF15543.6 VDK88972.1 - 0.027 14.3 0.2 0.062 13.1 0.2 1.5 1 0 0 1 1 1 0 Bacterial toxin 5 HSF_DNA-bind PF00447.17 VDK88973.1 - 2.3e-28 98.7 1.1 5.3e-28 97.5 1.1 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding MobL PF18555.1 VDK88973.1 - 0.006 15.9 0.2 0.0094 15.2 0.2 1.2 1 0 0 1 1 1 1 MobL relaxases YscO PF07321.12 VDK88973.1 - 0.012 15.6 1.6 0.029 14.3 1.6 1.6 1 0 0 1 1 1 0 Type III secretion protein YscO DUF484 PF04340.12 VDK88973.1 - 0.034 13.9 5.9 0.28 10.9 5.8 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF484 ZapB PF06005.12 VDK88973.1 - 0.069 13.6 6.9 0.046 14.1 4.7 1.9 2 0 0 2 2 2 0 Cell division protein ZapB BRE1 PF08647.11 VDK88973.1 - 0.11 12.6 2.5 0.17 12.0 1.4 1.8 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Ets PF00178.22 VDK88973.1 - 0.14 12.6 0.2 0.49 10.9 0.0 2.0 2 0 0 2 2 2 0 Ets-domain YabA PF06156.13 VDK88973.1 - 0.14 12.8 1.4 0.4 11.3 1.4 1.7 1 0 0 1 1 1 0 Initiation control protein YabA Imm6 PF14434.6 VDK88973.1 - 0.17 11.9 0.1 0.33 10.9 0.1 1.4 1 0 0 1 1 1 0 Immunity protein Imm6 Tup_N PF08581.10 VDK88973.1 - 0.19 12.1 3.0 0.47 10.8 3.0 1.6 1 0 0 1 1 1 0 Tup N-terminal GIT_CC PF16559.5 VDK88973.1 - 0.35 10.8 3.6 1.1 9.2 3.6 1.9 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf-C2H2 PF00096.26 VDK88975.1 - 8.9e-16 57.4 20.1 4.1e-06 27.0 3.8 4.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK88975.1 - 6.8e-12 45.2 19.0 0.0014 19.3 0.5 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDK88975.1 - 4e-09 36.5 22.7 6.5e-05 23.2 2.8 4.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-met PF12874.7 VDK88975.1 - 2.5e-08 34.0 20.3 0.0054 17.1 0.9 4.4 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDK88975.1 - 0.00028 21.1 21.3 0.019 15.3 2.1 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 VDK88975.1 - 0.016 15.1 9.4 1.1 9.3 1.5 3.5 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Pim PF16765.5 VDK88975.1 - 0.025 14.8 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Pesticin immunity protein zf-C2H2_6 PF13912.6 VDK88975.1 - 0.14 12.2 0.4 0.14 12.2 0.4 3.9 3 1 0 3 3 3 0 C2H2-type zinc finger HNH PF01844.23 VDK88975.1 - 0.16 12.1 0.4 0.16 12.1 0.4 3.8 4 1 1 5 5 5 0 HNH endonuclease Zn-ribbon_8 PF09723.10 VDK88975.1 - 0.24 11.5 5.4 9.3 6.5 0.1 3.3 3 0 0 3 3 3 0 Zinc ribbon domain zf-FCS PF06467.14 VDK88975.1 - 0.4 10.7 6.9 2.8 7.9 2.3 2.6 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-MYST PF17772.1 VDK88975.1 - 0.8 9.4 10.5 1.1 8.9 0.2 3.4 2 1 2 4 4 4 0 MYST family zinc finger domain zf-Di19 PF05605.12 VDK88975.1 - 4.1 7.8 12.2 0.41 11.0 4.1 2.6 1 1 2 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 VDK88975.1 - 9.1 6.1 13.2 0.44 10.4 0.8 3.6 4 0 0 4 4 4 0 zinc-finger C2H2-type Neur_chan_LBD PF02931.23 VDK88976.1 - 1.6e-53 181.4 1.5 4.3e-53 180.0 1.5 1.6 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain CHDCT2 PF08074.11 VDK88978.1 - 1.7e-84 282.2 0.7 5.3e-84 280.6 0.7 1.9 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain SNF2_N PF00176.23 VDK88978.1 - 1.5e-56 191.7 0.0 3.3e-56 190.5 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF1086 PF06461.11 VDK88978.1 - 8.9e-53 177.8 0.0 2.4e-52 176.4 0.0 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) DUF1087 PF06465.13 VDK88978.1 - 1.1e-26 92.6 8.5 1.1e-26 92.6 8.5 3.4 4 0 0 4 4 2 1 Domain of Unknown Function (DUF1087) Helicase_C PF00271.31 VDK88978.1 - 7.7e-23 81.0 0.0 1.6e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PHD PF00628.29 VDK88978.1 - 3.7e-20 71.6 27.0 1.3e-10 41.0 6.4 2.6 2 0 0 2 2 2 2 PHD-finger CHDNT PF08073.12 VDK88978.1 - 3.7e-16 58.8 0.2 9.8e-16 57.5 0.2 1.8 1 0 0 1 1 1 1 CHDNT (NUC034) domain Chromo PF00385.24 VDK88978.1 - 5.1e-12 45.5 9.5 9.6e-09 35.0 1.6 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 VDK88978.1 - 5.7e-07 29.7 0.0 8.7e-06 25.8 0.0 3.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 VDK88978.1 - 1e-05 24.9 0.0 1e-05 24.9 0.0 2.3 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 VDK88978.1 - 0.0028 17.5 0.0 0.038 13.8 0.0 2.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 VDK88978.1 - 0.073 13.3 0.0 0.59 10.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain FUSC PF04632.12 VDK88978.1 - 0.16 10.5 6.5 0.38 9.2 6.5 1.5 1 0 0 1 1 1 0 Fusaric acid resistance protein family zf-PHD-like PF15446.6 VDK88978.1 - 0.17 11.5 10.8 1.3 8.6 0.9 3.1 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 VDK88978.1 - 0.39 10.3 11.1 4.1 7.1 0.6 2.7 2 0 0 2 2 2 0 PHD-finger zf-RanBP PF00641.18 VDK88978.1 - 1.3 8.4 8.4 4.3 6.8 1.2 2.8 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others UNC80 PF15778.5 VDK88979.1 - 3.3e-74 248.6 0.2 6.2e-74 247.7 0.2 1.5 1 0 0 1 1 1 1 Cation channel complex component UNC80 DUF501 PF04417.12 VDK88987.1 - 0.0001 22.1 0.4 0.00019 21.3 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF501) PH PF00169.29 VDK88988.1 - 1.5e-09 38.3 1.2 3.2e-09 37.3 1.2 1.6 1 0 0 1 1 1 1 PH domain SLC12 PF03522.15 VDK88988.1 - 0.0046 16.0 3.8 0.0083 15.2 3.8 1.4 1 0 0 1 1 1 1 Solute carrier family 12 EPL1 PF10513.9 VDK88988.1 - 0.011 16.1 5.8 0.011 16.1 5.8 2.2 3 0 0 3 3 3 0 Enhancer of polycomb-like RA PF00788.23 VDK88988.1 - 0.015 16.0 0.0 0.015 16.0 0.0 2.5 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain DUF2722 PF10846.8 VDK88988.1 - 0.018 14.0 20.4 0.038 12.9 20.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Caskin-Pro-rich PF16907.5 VDK88988.1 - 0.048 14.2 1.1 0.048 14.2 1.1 3.4 4 0 0 4 4 4 0 Proline rich region of Caskin proteins RLL PF10036.9 VDK88988.1 - 0.53 10.1 15.1 0.99 9.2 14.4 1.7 1 1 1 2 2 2 0 RNA transcription, translation and transport factor protein PH_11 PF15413.6 VDK88988.1 - 5.4 7.5 10.1 0.072 13.5 1.8 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain CPSF100_C PF13299.6 VDK88988.1 - 5.5 7.1 7.3 13 5.9 7.3 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EMC1_C PF07774.13 VDK88992.1 - 2e-66 223.7 0.0 3.9e-66 222.8 0.0 1.5 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 VDK88992.1 - 0.00073 19.2 0.0 0.49 9.9 0.0 2.4 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 VDK88992.1 - 0.016 15.1 1.0 0.29 11.1 0.1 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat DUF3908 PF13048.6 VDK88992.1 - 0.038 14.2 0.2 0.59 10.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3908) DDOST_48kD PF03345.14 VDK88995.1 - 3.7e-143 477.3 0.0 4.2e-143 477.1 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta zf-C3H1 PF10650.9 VDK88996.1 - 0.00031 20.4 0.4 0.00067 19.3 0.4 1.6 1 0 0 1 1 1 1 Putative zinc-finger domain ParD_antitoxin PF03693.14 VDK88996.1 - 0.18 12.2 3.9 3.1 8.3 0.0 3.7 3 0 0 3 3 3 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Metallophos PF00149.28 VDK88998.1 - 4.6e-07 30.5 0.0 8.3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDK88998.1 - 0.011 16.2 0.0 0.024 15.1 0.0 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Tyr-DNA_phospho PF06087.12 VDK88999.1 - 1.5e-92 310.7 0.0 2e-92 310.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase Peptidase_C48 PF02902.19 VDK88999.1 - 8.6e-10 38.8 0.2 1.5e-09 38.0 0.2 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Ndufs5 PF10200.9 VDK89004.1 - 1.3e-08 35.0 0.5 2.5e-08 34.1 0.5 1.5 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Tim17 PF02466.19 VDK89007.1 - 3.6e-16 59.5 3.8 5e-16 59.1 3.8 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Gly-zipper_YMGG PF13441.6 VDK89007.1 - 1.7 8.4 11.3 0.28 11.0 7.6 1.5 2 0 0 2 2 2 0 YMGG-like Gly-zipper CTD_bind PF04818.13 VDK89008.1 - 1.5e-12 48.2 0.1 4.9e-12 46.5 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CTK3 PF12243.8 VDK89008.1 - 0.0061 16.6 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 Ion_trans PF00520.31 VDK89011.1 - 2.3e-41 141.7 15.6 3.2e-41 141.2 15.6 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 VDK89011.1 - 1.7e-27 95.6 0.3 4.6e-27 94.2 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain Shal-type PF11601.8 VDK89011.1 - 2.9e-14 52.3 12.3 4.6e-14 51.6 12.3 1.4 1 0 0 1 1 1 1 Shal-type voltage-gated potassium channels, N-terminal Ion_trans_2 PF07885.16 VDK89011.1 - 8.9e-13 48.0 5.6 8.9e-13 48.0 5.6 2.3 2 0 0 2 2 2 1 Ion channel DUF3399 PF11879.8 VDK89011.1 - 1.3e-05 25.4 0.4 1.3e-05 25.4 0.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3399) BTB_3 PF16017.5 VDK89011.1 - 0.0095 16.0 0.0 0.034 14.2 0.0 2.0 1 0 0 1 1 1 1 BTB/POZ domain COX2-transmemb PF09125.10 VDK89011.1 - 0.017 14.9 4.4 0.6 10.0 2.0 3.0 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane Cytochrom_B_C PF00032.17 VDK89011.1 - 0.021 15.1 2.1 0.036 14.4 0.8 2.0 1 1 1 2 2 2 0 Cytochrome b(C-terminal)/b6/petD PKD_channel PF08016.12 VDK89011.1 - 2 7.0 10.7 4.8 5.7 10.7 1.7 1 1 0 1 1 1 0 Polycystin cation channel DENN PF02141.21 VDK89012.1 - 5.3e-29 101.5 6.0 1.3e-28 100.2 6.0 1.7 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 VDK89012.1 - 3e-19 69.5 0.4 3e-19 69.5 0.4 2.0 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 VDK89012.1 - 0.00068 19.6 0.8 0.38 10.8 0.2 2.7 2 0 0 2 2 2 2 dDENN domain SPA PF08616.10 VDK89012.1 - 0.02 14.8 1.2 0.055 13.4 0.4 2.1 2 0 0 2 2 2 0 Stabilization of polarity axis UvsW PF11637.8 VDK89012.1 - 0.079 13.1 0.5 0.3 11.2 0.1 2.2 2 0 0 2 2 2 0 ATP-dependant DNA helicase UvsW DUF1908 PF08926.11 VDK89012.1 - 0.53 9.3 8.2 2.2 7.3 8.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) zf-RRN7 PF11781.8 VDK89015.1 - 7.1e-06 25.6 5.6 2e-05 24.2 5.6 1.8 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-RRPl_C4 PF17026.5 VDK89015.1 - 0.1 12.7 1.9 12 6.1 0.2 3.1 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF1325 PF07039.11 VDK89016.1 - 8.2e-31 106.8 0.2 1.8e-29 102.5 0.0 2.3 2 0 0 2 2 2 1 SGF29 tudor-like domain TUDOR_5 PF18359.1 VDK89016.1 - 0.0033 17.1 0.0 0.008 15.9 0.0 1.6 1 0 0 1 1 1 1 Histone methyltransferase Tudor domain 1 DUF5593 PF18007.1 VDK89016.1 - 0.043 14.5 0.0 0.31 11.7 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5593) ANAPC15 PF15243.6 VDK89016.1 - 0.052 13.9 0.6 0.12 12.8 0.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Agenet PF05641.12 VDK89016.1 - 0.13 12.7 0.0 1.3 9.6 0.0 2.4 2 0 0 2 2 2 0 Agenet domain ISG65-75 PF11727.8 VDK89016.1 - 0.14 11.4 1.3 0.21 10.8 1.3 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF812 PF05667.11 VDK89016.1 - 0.43 9.4 7.6 0.53 9.1 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ZapB PF06005.12 VDK89016.1 - 1.4 9.4 8.1 0.36 11.3 0.2 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Pkinase PF00069.25 VDK89020.1 - 3.6e-36 124.9 0.0 5.1e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89020.1 - 7.3e-34 117.2 0.0 1e-33 116.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2777 PF10949.8 VDK89020.1 - 0.9 9.2 5.8 0.47 10.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2777) Translin PF01997.16 VDK89021.1 - 2.9e-45 154.8 0.1 3.8e-45 154.4 0.1 1.1 1 0 0 1 1 1 1 Translin family Ribosomal_L5e PF17144.4 VDK89023.1 - 6.2e-82 273.4 0.9 6.2e-82 273.4 0.9 2.4 3 0 0 3 3 3 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 VDK89023.1 - 4.5e-31 107.7 7.4 4.5e-31 107.7 7.4 2.1 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region DUF1476 PF07345.11 VDK89023.1 - 2.7e-05 24.5 1.0 5.9e-05 23.4 1.0 1.6 1 0 0 1 1 1 1 ATPase inhibitor subunit zeta PA28_beta PF02252.18 VDK89023.1 - 0.022 14.4 0.5 0.044 13.5 0.5 1.5 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit Vanabin-2 PF11437.8 VDK89024.1 - 0.2 11.8 13.6 0.4 10.8 13.6 1.4 1 0 0 1 1 1 0 Vanadium-binding protein 2 Mpv17_PMP22 PF04117.12 VDK89025.1 - 0.11 12.7 1.0 0.28 11.5 0.0 2.2 4 0 0 4 4 4 0 Mpv17 / PMP22 family KAP PF05804.12 VDK89027.1 - 0.0012 17.1 0.2 0.0025 16.0 0.1 1.5 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) SPG48 PF14764.6 VDK89027.1 - 0.074 13.5 0.2 8.7 6.9 0.0 2.5 2 0 0 2 2 2 0 AP-5 complex subunit, vesicle trafficking RESP18 PF14948.6 VDK89027.1 - 0.16 12.3 0.0 0.35 11.2 0.0 1.5 1 0 0 1 1 1 0 RESP18 domain Glycos_transf_1 PF00534.20 VDK89036.1 - 1.3e-38 132.2 0.2 2.1e-38 131.6 0.1 1.3 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 VDK89036.1 - 2.9e-18 66.6 0.0 4.8e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 VDK89036.1 - 1e-10 41.8 0.0 1.8e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 VDK89036.1 - 0.003 17.6 0.0 0.0044 17.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Epimerase_2 PF02350.19 VDK89036.1 - 0.049 12.5 0.0 0.058 12.3 0.0 1.2 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Piwi PF02171.17 VDK89038.1 - 1.2e-59 202.0 5.9 1.6e-59 201.6 3.2 2.4 3 0 0 3 3 3 1 Piwi domain ArgoN PF16486.5 VDK89038.1 - 7.4e-06 26.6 0.2 4.2e-05 24.2 0.1 2.3 2 1 0 2 2 2 1 N-terminal domain of argonaute ArgoL2 PF16488.5 VDK89038.1 - 0.0033 17.7 0.0 0.013 15.8 0.0 2.2 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 VDK89038.1 - 0.029 14.6 0.3 0.77 10.1 0.1 3.6 4 0 0 4 4 4 0 Mid domain of argonaute FAST_1 PF06743.15 VDK89040.1 - 1.2e-10 41.2 5.3 1.3e-05 25.1 0.0 4.9 3 1 2 5 5 5 2 FAST kinase-like protein, subdomain 1 FliG_M PF14841.6 VDK89040.1 - 0.012 15.8 0.1 5.2 7.4 0.0 3.2 3 0 0 3 3 3 0 FliG middle domain Peptidase_C48 PF02902.19 VDK89040.1 - 0.042 13.7 0.3 0.08 12.8 0.3 1.5 1 0 0 1 1 1 0 Ulp1 protease family, C-terminal catalytic domain zf-RING_5 PF14634.6 VDK89042.1 - 1.2e-05 25.2 10.8 2.3e-05 24.3 10.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 VDK89042.1 - 0.02 14.8 8.6 0.054 13.4 8.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) NupH_GANP PF16768.5 VDK89042.1 - 0.061 13.0 3.2 2.5 7.7 0.1 2.7 1 1 2 3 3 3 0 Nucleoporin homology of Germinal-centre associated nuclear protein zf-CHY PF05495.12 VDK89042.1 - 0.072 13.6 4.1 0.15 12.5 4.1 1.5 1 0 0 1 1 1 0 CHY zinc finger zf-C3HC4 PF00097.25 VDK89042.1 - 0.087 12.7 10.3 0.19 11.7 10.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK89042.1 - 0.23 11.3 6.5 0.92 9.4 6.5 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 PASTA PF03793.19 VDK89042.1 - 1.2 9.0 3.5 15 5.5 0.3 4.1 3 2 1 4 4 4 0 PASTA domain zf-C3HC4_2 PF13923.6 VDK89042.1 - 2.4 8.1 10.1 24 4.9 10.1 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDK89042.1 - 6 7.3 8.8 14 6.1 8.8 1.7 1 1 0 1 1 1 0 Ring finger domain FYVE PF01363.21 VDK89042.1 - 7.3 6.8 7.8 32 4.7 8.0 1.8 1 1 0 1 1 1 0 FYVE zinc finger GEMIN8 PF15348.6 VDK89048.1 - 0.13 12.5 5.0 0.16 12.3 5.0 1.1 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Det1 PF09737.9 VDK89057.1 - 4.4e-72 243.4 0.1 5.9e-72 243.0 0.1 1.2 1 0 0 1 1 1 1 De-etiolated protein 1 Det1 Ras PF00071.22 VDK89058.1 - 6.6e-25 87.6 0.0 8.7e-25 87.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK89058.1 - 3.8e-06 27.1 0.0 1e-05 25.8 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 VDK89058.1 - 0.0075 15.5 0.2 0.04 13.1 0.2 2.0 1 1 0 1 1 1 1 NB-ARC domain DUF87 PF01935.17 VDK89058.1 - 0.095 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain Pox_C4_C10 PF03336.13 VDK89058.1 - 0.1 11.7 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 Poxvirus C4/C10 protein AAA_16 PF13191.6 VDK89058.1 - 0.13 12.6 0.0 0.26 11.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain IQCJ-SCHIP1 PF15157.6 VDK89058.1 - 0.96 9.3 6.1 2.5 7.9 6.1 1.6 1 1 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif Senescence PF06911.12 VDK89059.1 - 1.9e-18 67.4 9.7 6.5e-16 59.2 2.4 2.8 2 1 1 3 3 3 2 Senescence-associated protein Inp1 PF12634.7 VDK89059.1 - 4.8e-09 36.3 0.0 1.2e-08 35.1 0.0 1.7 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 SRP68 PF16969.5 VDK89059.1 - 0.023 13.7 0.5 0.058 12.4 0.2 1.7 2 0 0 2 2 2 0 RNA-binding signal recognition particle 68 TPR_1 PF00515.28 VDK89059.1 - 0.073 12.9 0.2 0.17 11.7 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat MIT PF04212.18 VDK89059.1 - 0.21 11.7 2.8 0.21 11.7 0.7 2.1 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain AlaDh_PNT_C PF01262.21 VDK89059.1 - 0.6 9.4 4.6 0.12 11.6 0.3 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PDZ_6 PF17820.1 VDK89061.1 - 1e-06 28.5 0.0 2.1e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 PDZ domain DUF4749 PF15936.5 VDK89061.1 - 0.0017 19.4 3.2 0.0017 19.4 3.2 2.6 2 2 0 2 2 2 1 Domain of unknown function (DUF4749) PDZ_2 PF13180.6 VDK89061.1 - 0.033 14.5 0.0 0.068 13.5 0.0 1.5 1 0 0 1 1 1 0 PDZ domain TPR_12 PF13424.6 VDK89062.1 - 8.9e-10 38.7 14.2 2.2e-06 27.9 0.2 5.9 3 2 4 7 7 7 2 Tetratricopeptide repeat Rapsyn_N PF10579.9 VDK89062.1 - 3e-06 27.2 1.9 0.00081 19.4 0.7 3.2 2 1 0 2 2 2 1 Rapsyn N-terminal myristoylation and linker region TPR_8 PF13181.6 VDK89062.1 - 5.6e-06 26.2 4.7 0.36 11.2 0.1 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDK89062.1 - 1.6e-05 24.6 4.9 1.4 9.2 0.1 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat zf-RING_2 PF13639.6 VDK89062.1 - 8.7e-05 22.8 8.0 8.7e-05 22.8 8.0 3.2 4 0 0 4 4 2 1 Ring finger domain TPR_1 PF00515.28 VDK89062.1 - 0.00013 21.6 2.9 2.1 8.3 0.2 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat zf-rbx1 PF12678.7 VDK89062.1 - 0.0032 17.7 6.1 0.0032 17.7 6.1 3.0 4 1 0 4 4 2 1 RING-H2 zinc finger domain TPR_10 PF13374.6 VDK89062.1 - 0.0055 16.5 10.3 2.4 8.1 0.1 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat zf-RING_11 PF17123.5 VDK89062.1 - 0.011 15.5 3.7 0.011 15.5 3.7 2.4 2 0 0 2 2 2 0 RING-like zinc finger TPR_7 PF13176.6 VDK89062.1 - 0.013 15.5 10.5 1.3 9.2 0.0 5.4 6 1 0 6 6 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 VDK89062.1 - 0.014 16.1 2.2 87 4.3 0.0 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat zf-RING-like PF08746.11 VDK89062.1 - 0.018 15.4 3.7 0.018 15.4 3.7 2.6 3 0 0 3 3 2 0 RING-like domain zf-RING_5 PF14634.6 VDK89062.1 - 0.022 14.7 13.2 0.022 14.7 13.2 2.5 3 0 0 3 3 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 VDK89062.1 - 0.028 14.3 8.2 0.028 14.3 8.2 2.6 3 0 0 3 3 2 0 Zinc finger, C3HC4 type (RING finger) TPR_MalT PF17874.1 VDK89062.1 - 0.031 13.6 4.8 0.042 13.2 0.0 2.8 1 1 2 3 3 3 0 MalT-like TPR region PHD PF00628.29 VDK89062.1 - 0.05 13.5 10.5 0.23 11.4 10.5 2.2 1 0 0 1 1 1 0 PHD-finger FRB_dom PF08771.11 VDK89062.1 - 0.093 13.2 0.7 1.2 9.6 0.0 2.7 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain Zn_ribbon_17 PF17120.5 VDK89062.1 - 1.7 8.4 12.3 0.19 11.4 6.9 2.3 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 VDK89062.1 - 1.8 8.7 9.0 17 5.5 9.0 2.8 1 1 0 1 1 1 0 Zinc-finger zf-ANAPC11 PF12861.7 VDK89062.1 - 3 7.9 8.8 0.34 11.0 3.4 2.2 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RSV_NS2 PF03113.14 VDK89063.1 - 0.093 12.8 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Respiratory synctial virus non-structural protein NS2 CBFD_NFYB_HMF PF00808.23 VDK89066.1 - 1.6e-19 70.0 0.2 3.3e-19 68.9 0.2 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 VDK89066.1 - 1.8e-14 54.2 0.5 3e-14 53.5 0.5 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 VDK89066.1 - 0.0064 16.6 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-T_C PF15511.6 VDK89066.1 - 0.065 13.4 0.2 0.14 12.3 0.2 1.5 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold RhoGEF PF00621.20 VDK89067.1 - 6.3e-25 88.5 1.7 2e-24 86.8 0.0 2.4 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 VDK89067.1 - 5.4e-06 26.9 1.1 1.7e-05 25.2 1.1 1.8 1 0 0 1 1 1 1 PH domain PH_10 PF15411.6 VDK89067.1 - 0.0012 19.1 1.4 0.0043 17.3 1.4 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain Chorein_N PF12624.7 VDK89074.1 - 1.2e-14 54.4 0.2 6.7e-14 52.0 0.1 2.3 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 HSL_N PF06350.12 VDK89075.1 - 6.5e-81 271.6 0.0 1.1e-80 270.8 0.0 1.3 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Abhydrolase_3 PF07859.13 VDK89075.1 - 6.8e-39 133.9 0.0 1.1e-27 97.3 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 VDK89075.1 - 5.1e-10 38.8 0.1 1.4e-09 37.3 0.1 1.7 1 0 0 1 1 1 1 Steryl acetyl hydrolase SIR4_SID PF16991.5 VDK89075.1 - 1.8 8.6 7.0 0.09 12.8 0.3 2.1 2 0 0 2 2 2 0 Sir4 SID domain Hydrolase_4 PF12146.8 VDK89079.1 - 2.6e-14 53.1 0.0 7.8e-09 35.2 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 VDK89079.1 - 3.6e-10 39.9 0.0 1.7e-05 24.6 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 VDK89079.1 - 6.2e-05 22.9 0.0 0.0004 20.2 0.0 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 VDK89079.1 - 0.00011 22.8 0.0 0.00054 20.6 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 VDK89079.1 - 0.00021 21.0 0.0 0.00037 20.2 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 VDK89079.1 - 0.001 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family LIP PF03583.14 VDK89079.1 - 0.0023 17.3 0.1 0.47 9.7 0.1 2.2 2 0 0 2 2 2 2 Secretory lipase Peptidase_S9 PF00326.21 VDK89079.1 - 0.01 15.3 0.0 0.11 12.0 0.0 2.0 1 1 0 1 1 1 0 Prolyl oligopeptidase family DUF818 PF05677.12 VDK89079.1 - 0.035 13.1 0.2 0.053 12.5 0.2 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Abhydrolase_5 PF12695.7 VDK89079.1 - 0.047 13.4 0.0 1.6 8.4 0.0 2.3 1 1 1 2 2 2 0 Alpha/beta hydrolase family Kunitz_BPTI PF00014.23 VDK89081.1 - 8.5e-28 96.4 29.3 5e-14 52.3 13.7 2.6 2 0 0 2 2 2 2 Kunitz/Bovine pancreatic trypsin inhibitor domain Sod_Ni PF09055.11 VDK89081.1 - 0.15 12.6 0.8 0.3 11.7 0.3 1.7 1 1 0 1 1 1 0 Nickel-containing superoxide dismutase Nucleoporin_N PF08801.11 VDK89087.1 - 8.6e-34 117.0 1.2 1.6e-33 116.1 0.0 1.9 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.14 VDK89087.1 - 4.1e-18 65.5 0.2 6.6e-18 64.8 0.2 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Astacin PF01400.24 VDK89090.1 - 7.6e-34 117.0 0.0 1.1e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) PqqD PF05402.12 VDK89091.1 - 0.043 14.1 4.3 1.4 9.3 0.3 3.0 3 0 0 3 3 3 0 Coenzyme PQQ synthesis protein D (PqqD) TAFH PF07531.14 VDK89091.1 - 0.052 13.7 2.0 0.43 10.7 0.4 2.9 3 1 0 3 3 3 0 NHR1 homology to TAF DUF4508 PF14969.6 VDK89091.1 - 0.052 13.8 1.0 18 5.7 0.0 3.1 1 1 1 3 3 3 0 Domain of unknown function (DUF4508) Gemini_AL1_M PF08283.11 VDK89091.1 - 0.1 12.7 0.6 2.4 8.3 0.1 2.8 1 1 1 3 3 3 0 Geminivirus rep protein central domain SATase_N PF06426.14 VDK89091.1 - 0.16 12.3 2.0 3.3 8.1 0.0 2.7 1 1 2 3 3 3 0 Serine acetyltransferase, N-terminal PIN_8 PF18476.1 VDK89091.1 - 0.28 11.0 3.5 0.34 10.7 2.8 1.5 1 1 0 1 1 1 0 PIN like domain Sec3_C_2 PF15278.6 VDK89091.1 - 0.47 10.8 6.5 0.85 10.0 1.3 3.1 1 1 1 3 3 3 0 Sec3 exocyst complex subunit CdiI_2 PF18593.1 VDK89091.1 - 0.54 10.9 6.8 0.54 10.9 1.1 2.9 1 1 0 3 3 3 0 CdiI immunity protein Importin_rep_6 PF18829.1 VDK89091.1 - 1.8 8.8 10.1 2.4 8.3 1.9 3.1 1 1 2 3 3 3 0 Importin repeat 6 EF-G-binding_N PF07299.11 VDK89091.1 - 4.5 7.9 9.7 18 5.9 0.3 3.3 2 1 0 3 3 3 0 Elongation factor G-binding protein, N-terminal Mob1_phocein PF03637.17 VDK89092.1 - 3.7e-35 121.5 1.4 4.7e-35 121.1 1.4 1.1 1 0 0 1 1 1 1 Mob1/phocein family Rad51 PF08423.11 VDK89093.1 - 1.7e-18 66.8 0.0 2e-18 66.6 0.0 1.0 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 VDK89093.1 - 6.7e-06 25.6 0.0 7.9e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 KaiC RecA PF00154.21 VDK89093.1 - 0.00023 20.7 0.0 0.00028 20.4 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein CSM2 PF16834.5 VDK89093.1 - 0.02 14.5 0.1 0.025 14.2 0.1 1.1 1 0 0 1 1 1 0 Shu complex component Csm2, DNA-binding AAA_25 PF13481.6 VDK89093.1 - 0.027 14.1 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 VDK89093.1 - 0.034 13.5 0.0 0.039 13.3 0.0 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain PduV-EutP PF10662.9 VDK89093.1 - 0.046 13.5 0.0 0.081 12.7 0.0 1.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Spin-Ssty PF02513.17 VDK89093.1 - 0.063 13.0 0.4 0.12 12.1 0.4 1.5 1 0 0 1 1 1 0 Spin/Ssty Family Rap_GAP PF02145.15 VDK89098.1 - 1.2e-66 223.9 0.0 2.1e-66 223.0 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP JAKMIP_CC3 PF16034.5 VDK89098.1 - 0.031 14.2 0.5 0.12 12.3 0.5 2.0 1 0 0 1 1 1 0 JAKMIP CC3 domain ALIX_LYPXL_bnd PF13949.6 VDK89098.1 - 0.037 13.3 1.6 0.072 12.4 1.0 1.7 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV DUF4164 PF13747.6 VDK89098.1 - 0.068 13.4 6.8 0.15 12.3 6.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) GAS PF13851.6 VDK89098.1 - 0.3 10.4 4.8 0.63 9.4 4.8 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding CENP-H PF05837.12 VDK89098.1 - 0.39 11.1 3.1 1.5 9.3 3.1 1.9 1 0 0 1 1 1 0 Centromere protein H (CENP-H) TMF_DNA_bd PF12329.8 VDK89098.1 - 2.5 8.2 8.0 2.5 8.1 6.1 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding SPT2 PF08243.11 VDK89101.1 - 1.4e-10 41.6 14.3 1.4e-10 41.6 14.3 3.8 5 0 0 5 5 5 1 SPT2 chromatin protein HUN PF08729.10 VDK89101.1 - 0.2 11.7 13.5 0.51 10.4 13.5 1.7 1 0 0 1 1 1 0 HPC2 and ubinuclein domain PAN_1 PF00024.26 VDK89103.1 - 5e-06 26.4 3.3 0.00071 19.5 2.0 2.9 2 1 0 2 2 2 2 PAN domain Tom37 PF10568.9 VDK89106.1 - 3.7e-24 85.4 0.4 2.3e-23 82.8 0.2 2.1 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 VDK89106.1 - 3e-20 71.8 0.1 7.2e-20 70.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 VDK89106.1 - 5.2e-12 46.4 0.0 1.1e-11 45.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain NIF PF03031.18 VDK89108.1 - 6.3e-24 84.5 0.3 1.4e-23 83.3 0.3 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 VDK89108.1 - 2.3e-09 37.5 0.5 9.5e-09 35.5 0.0 2.4 3 1 1 4 4 4 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 VDK89108.1 - 5.7e-08 32.6 0.2 1.6e-07 31.2 0.2 1.8 2 0 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 VDK89108.1 - 0.00015 22.0 0.3 0.00034 20.9 0.3 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 VDK89108.1 - 0.00035 20.9 0.1 0.0011 19.3 0.1 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Toprim PF01751.22 VDK89108.1 - 0.11 12.7 0.4 11 6.4 0.1 2.6 2 0 0 2 2 2 0 Toprim domain Pex14_N PF04695.13 VDK89108.1 - 5.7 7.6 6.8 9.9 6.8 6.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Syntaxin_2 PF14523.6 VDK89110.1 - 3.3e-16 59.5 1.0 3.3e-16 59.5 1.0 3.0 2 1 0 3 3 3 1 Syntaxin-like protein THOC7 PF05615.13 VDK89110.1 - 0.008 16.5 9.3 0.014 15.7 9.3 1.4 1 0 0 1 1 1 1 Tho complex subunit 7 DUF3619 PF12279.8 VDK89110.1 - 0.046 14.0 1.9 0.085 13.2 1.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Spc7 PF08317.11 VDK89110.1 - 0.1 11.5 13.1 0.14 11.0 13.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DivIC PF04977.15 VDK89110.1 - 0.49 10.2 0.0 0.49 10.2 0.0 2.7 2 1 1 3 3 3 0 Septum formation initiator Patched PF02460.18 VDK89114.1 - 1.8e-174 582.0 6.7 2.5e-174 581.6 6.7 1.1 1 0 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 VDK89114.1 - 3.7e-37 127.5 11.7 7.1e-36 123.4 3.4 2.6 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK89114.1 - 2.1e-10 40.1 5.9 4.4e-08 32.4 0.9 2.3 2 0 0 2 2 2 2 MMPL family ACR_tran PF00873.19 VDK89114.1 - 0.041 11.5 9.5 0.16 9.6 2.3 2.1 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Fam20C PF06702.12 VDK89116.1 - 6.9e-84 281.0 0.3 1.4e-83 280.1 0.3 1.5 1 0 0 1 1 1 1 Golgi casein kinase, C-terminal, Fam20 FAM198 PF15051.6 VDK89116.1 - 0.00075 18.5 0.1 0.0028 16.6 0.0 1.8 1 1 1 2 2 2 1 FAM198 protein HipA_C PF07804.12 VDK89116.1 - 0.11 12.1 0.0 0.58 9.8 0.1 2.1 3 0 0 3 3 3 0 HipA-like C-terminal domain RAWUL PF16207.5 VDK89119.1 - 0.033 14.8 0.0 0.066 13.9 0.0 1.5 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like bZIP_1 PF00170.21 VDK89125.1 - 2.4e-06 27.5 7.4 4.3e-06 26.7 7.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 VDK89125.1 - 0.0015 19.0 1.8 0.0015 19.0 1.8 2.7 3 0 0 3 3 3 1 bZIP Maf transcription factor bZIP_2 PF07716.15 VDK89125.1 - 0.0033 17.5 7.5 0.0067 16.5 7.5 1.4 1 0 0 1 1 1 1 Basic region leucine zipper PVL_ORF50 PF07768.11 VDK89125.1 - 0.068 13.5 1.6 0.14 12.5 1.6 1.5 1 0 0 1 1 1 0 PVL ORF-50-like family FSA_C PF10479.9 VDK89126.1 - 1.3e-32 112.8 0.1 1.4e-16 59.8 0.1 2.4 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus VPS9 PF02204.18 VDK89127.1 - 5.4e-27 94.0 0.0 2.4e-26 91.9 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 VDK89127.1 - 8.8e-19 67.6 4.4 1e-18 67.4 1.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF5601) zf-A20 PF01754.16 VDK89127.1 - 3.2e-11 43.0 5.1 6.5e-11 42.0 5.1 1.5 1 0 0 1 1 1 1 A20-like zinc finger CCAP PF11105.8 VDK89127.1 - 0.00021 21.3 0.4 0.032 14.2 0.0 2.6 2 0 0 2 2 2 1 Arthropod cardioacceleratory peptide 2a DUF4618 PF15397.6 VDK89127.1 - 0.00028 20.4 4.1 0.03 13.8 0.5 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4618) TcpS PF17456.2 VDK89127.1 - 0.19 11.7 1.5 0.5 10.4 0.4 2.1 2 0 0 2 2 2 0 Toxin-coregulated pilus protein S VPS11_C PF12451.8 VDK89127.1 - 0.21 11.8 4.3 0.62 10.3 0.9 2.7 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal CheZ PF04344.13 VDK89127.1 - 0.29 11.0 4.9 7.3 6.5 0.2 2.5 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ dCMP_cyt_deam_1 PF00383.23 VDK89128.1 - 2.3e-19 69.2 0.1 3.1e-19 68.7 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 VDK89128.1 - 6.9e-15 55.0 0.0 9.7e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 VDK89128.1 - 4.1e-05 23.7 0.0 9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 VDK89128.1 - 0.00017 21.7 0.1 0.00024 21.2 0.1 1.3 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 VDK89128.1 - 0.00022 21.4 0.1 0.00031 20.9 0.1 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 Bd3614-deam PF14439.6 VDK89128.1 - 0.00037 20.6 0.5 0.0026 17.8 0.5 2.0 1 1 0 1 1 1 1 Bd3614-like deaminase APOBEC_N PF08210.11 VDK89128.1 - 0.0011 18.9 0.1 0.0016 18.4 0.1 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC3 PF18771.1 VDK89128.1 - 0.0011 19.0 0.0 0.0021 18.2 0.0 1.4 1 0 0 1 1 1 1 APOBEC3 NAD2 PF18782.1 VDK89128.1 - 0.0061 16.7 0.1 0.009 16.1 0.1 1.3 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 APOBEC4_like PF18774.1 VDK89128.1 - 0.046 13.6 0.0 0.083 12.8 0.0 1.4 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase AID PF18767.1 VDK89128.1 - 0.092 12.8 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 Activation induced deaminase Inv-AAD PF18785.1 VDK89128.1 - 0.095 12.6 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase HAD_2 PF13419.6 VDK89129.1 - 2.6e-22 79.8 0.0 3.2e-22 79.5 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 VDK89129.1 - 6e-10 39.8 0.1 2.6e-08 34.4 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDK89129.1 - 0.0048 17.3 0.0 0.0058 17.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 VDK89129.1 - 0.069 13.3 0.0 16 5.7 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 VDK89131.1 - 1e-22 81.1 0.0 1.3e-22 80.8 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 VDK89131.1 - 1e-13 52.1 0.0 1.5e-12 48.2 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDK89131.1 - 0.00092 19.7 0.0 0.0012 19.2 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 VDK89131.1 - 0.076 12.4 0.0 0.13 11.7 0.0 1.4 1 1 0 1 1 1 0 Putative Phosphatase Hydrolase_6 PF13344.6 VDK89131.1 - 0.15 12.2 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Ground-like PF04155.18 VDK89133.1 - 7e-20 71.5 1.5 1.6e-19 70.3 1.5 1.6 1 0 0 1 1 1 1 Ground-like domain Collagen PF01391.18 VDK89137.1 - 4.9e-70 231.2 257.0 6.6e-10 38.6 25.3 10.8 6 4 4 10 10 10 10 Collagen triple helix repeat (20 copies) Caskin-Pro-rich PF16907.5 VDK89141.1 - 0.041 14.4 2.3 0.041 14.4 2.3 2.6 3 0 0 3 3 3 0 Proline rich region of Caskin proteins Tmemb_cc2 PF10267.9 VDK89141.1 - 0.4 9.8 2.0 0.54 9.4 2.0 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF1364 PF07102.12 VDK89141.1 - 1.5 8.8 8.5 0.045 13.6 1.4 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1364) DENN PF02141.21 VDK89142.1 - 1.3e-47 162.2 1.0 2.6e-47 161.2 1.0 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 VDK89142.1 - 4.3e-06 26.6 0.0 1.3e-05 25.1 0.0 1.9 1 0 0 1 1 1 1 dDENN domain SPA PF08616.10 VDK89142.1 - 8.8e-05 22.4 0.6 0.00023 21.1 0.1 1.8 2 0 0 2 2 2 1 Stabilization of polarity axis uDENN PF03456.18 VDK89142.1 - 0.00069 20.3 0.5 0.0016 19.1 0.5 1.6 1 0 0 1 1 1 1 uDENN domain Pkinase PF00069.25 VDK89143.1 - 5.3e-19 68.6 0.0 5.8e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89143.1 - 1.3e-10 41.0 0.0 1.6e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDK89143.1 - 4.4e-08 32.3 0.0 5.8e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDK89143.1 - 0.00016 21.7 0.0 0.00037 20.5 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1972 PF09314.11 VDK89143.1 - 0.094 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) MFS_1 PF07690.16 VDK89147.1 - 1.2e-41 142.8 27.8 1.7e-40 139.0 18.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2244 PF10003.9 VDK89149.1 - 1.1 8.9 11.9 0.21 11.3 3.1 3.1 3 0 0 3 3 3 0 Integral membrane protein (DUF2244) CARD PF00619.21 VDK89150.1 - 2.3e-10 40.3 0.5 3.8e-10 39.6 0.5 1.3 1 1 0 1 1 1 1 Caspase recruitment domain CARD_2 PF16739.5 VDK89150.1 - 9.3e-07 28.8 0.3 1.2e-06 28.4 0.3 1.1 1 0 0 1 1 1 1 Caspase recruitment domain Autophagy_N PF03986.13 VDK89153.1 - 4.4e-47 159.5 0.4 7.2e-47 158.8 0.4 1.3 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 VDK89153.1 - 8.8e-20 71.0 0.3 2.3e-19 69.7 0.3 1.8 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 VDK89153.1 - 2.3e-15 55.8 0.9 4.7e-15 54.8 0.9 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Patched PF02460.18 VDK89164.1 - 1.2e-172 576.1 22.5 4e-154 514.8 18.1 2.0 1 1 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK89164.1 - 7.6e-24 84.3 2.2 7.6e-24 84.3 2.2 3.3 3 1 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK89164.1 - 0.002 17.1 0.3 0.002 17.1 0.3 1.8 2 0 0 2 2 2 1 MMPL family Metallophos PF00149.28 VDK89165.1 - 5.2e-20 72.8 0.4 7.8e-20 72.2 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Asp PF00026.23 VDK89166.1 - 3.2e-58 197.6 0.0 3.9e-58 197.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 VDK89166.1 - 9.7e-11 42.2 0.1 9.2e-09 35.8 0.1 2.1 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal A1_Propeptide PF07966.12 VDK89166.1 - 0.12 12.3 0.2 0.27 11.2 0.0 1.6 2 0 0 2 2 2 0 A1 Propeptide Asp_protease_2 PF13650.6 VDK89166.1 - 0.13 12.9 0.0 11 6.7 0.0 2.3 2 0 0 2 2 2 0 Aspartyl protease PD40 PF07676.12 VDK89167.1 - 3.2e-45 151.2 26.1 1.1e-12 47.5 0.8 8.1 8 0 0 8 8 8 7 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 VDK89167.1 - 2.9e-08 32.9 0.0 0.34 9.6 0.0 6.1 4 2 3 7 7 7 4 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pectate_lyase22 PF14583.6 VDK89167.1 - 1.3e-05 24.1 0.0 0.98 8.0 0.0 4.1 3 1 1 4 4 4 3 Oligogalacturonate lyase Ldh_1_N PF00056.23 VDK89169.1 - 1.5e-08 34.9 0.0 1.5e-08 34.8 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 VDK89169.1 - 0.078 12.1 0.0 0.078 12.1 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 VDK89169.1 - 0.12 11.9 0.3 0.12 11.8 0.3 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 VDK89169.1 - 0.15 11.1 0.0 0.15 11.1 0.0 1.0 1 0 0 1 1 1 0 RmlD substrate binding domain EphA2_TM PF14575.6 VDK89170.1 - 0.03 15.2 0.1 0.083 13.8 0.1 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF637 PF04830.13 VDK89170.1 - 0.044 13.6 1.0 0.096 12.5 1.0 1.5 1 0 0 1 1 1 0 Possible hemagglutinin (DUF637) LST1 PF05083.13 VDK89170.1 - 0.077 13.3 0.1 0.18 12.1 0.1 1.6 1 0 0 1 1 1 0 LST-1 protein Lectin_C PF00059.21 VDK89170.1 - 0.085 13.6 0.2 0.085 13.6 0.2 3.3 2 2 0 2 2 2 0 Lectin C-type domain UL45 PF05473.12 VDK89170.1 - 0.35 10.5 4.1 0.3 10.7 0.0 2.5 2 0 0 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like Alpha-amylase_C PF02806.18 VDK89174.1 - 6.1e-22 77.9 0.1 1.7e-21 76.5 0.0 1.8 2 0 0 2 2 2 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 VDK89174.1 - 5.6e-15 55.5 0.0 1.4e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 VDK89174.1 - 3e-11 43.5 1.3 1.9e-10 40.8 0.1 2.2 1 1 1 2 2 2 1 Alpha amylase, catalytic domain Cellulase PF00150.18 VDK89174.1 - 0.058 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) hDGE_amylase PF14701.6 VDK89174.1 - 0.083 12.0 0.1 0.15 11.1 0.1 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain TSP_1 PF00090.19 VDK89175.1 - 0.2 11.9 2.1 23 5.3 0.0 2.9 3 0 0 3 3 3 0 Thrombospondin type 1 domain CX9C PF16860.5 VDK89175.1 - 3.3 7.8 6.1 0.44 10.6 0.9 2.3 3 0 0 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, PH PF00169.29 VDK89178.1 - 8e-08 32.7 0.5 1.8e-07 31.6 0.5 1.6 1 1 0 1 1 1 1 PH domain PH_9 PF15410.6 VDK89178.1 - 1.3e-07 32.0 0.1 2e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain Vault_2 PF17794.1 VDK89180.1 - 0.14 12.6 0.1 0.29 11.6 0.1 1.5 1 1 0 1 1 1 0 Major Vault Protein repeat domain DUF1619 PF07773.11 VDK89181.1 - 1e-05 25.7 4.3 0.0004 20.4 4.3 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1619) CENP-B_dimeris PF09026.10 VDK89184.1 - 0.0011 19.3 11.1 0.0012 19.2 11.1 1.1 1 0 0 1 1 1 1 Centromere protein B dimerisation domain FAM176 PF14851.6 VDK89184.1 - 0.46 10.1 2.3 0.56 9.9 2.3 1.1 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 VDK89184.1 - 0.66 9.7 10.4 0.78 9.4 10.4 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 VDK89184.1 - 1.1 7.2 8.9 1.2 7.2 8.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 VDK89184.1 - 2.4 8.6 12.5 3.3 8.1 12.5 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 VDK89184.1 - 4.1 5.6 5.3 4.5 5.5 5.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 VDK89184.1 - 6.6 4.8 6.1 6.7 4.8 6.1 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 VDK89184.1 - 6.9 5.9 14.2 7.9 5.7 14.2 1.0 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 VDK89184.1 - 9.4 6.3 7.9 11 6.0 7.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Pou PF00157.17 VDK89185.1 - 2e-37 127.0 0.1 5.5e-37 125.6 0.1 1.7 1 0 0 1 1 1 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 VDK89185.1 - 2.7e-18 65.6 5.4 6.2e-18 64.4 5.4 1.7 1 0 0 1 1 1 1 Homeodomain HTH_31 PF13560.6 VDK89185.1 - 0.047 14.0 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain Homeobox_KN PF05920.11 VDK89185.1 - 0.058 13.3 0.1 0.19 11.7 0.1 1.9 2 0 0 2 2 2 0 Homeobox KN domain FERM_C PF09380.10 VDK89187.1 - 2.2e-19 69.6 0.0 6.6e-19 68.1 0.0 1.9 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 VDK89187.1 - 1.9e-14 53.3 0.0 5.6e-14 51.8 0.0 1.9 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 VDK89187.1 - 8.1e-13 48.8 0.1 2.6e-12 47.2 0.1 1.9 1 0 0 1 1 1 1 FERM central domain FA PF08736.11 VDK89187.1 - 5.8e-06 26.3 3.3 1.8e-05 24.7 3.3 1.9 1 0 0 1 1 1 1 FERM adjacent (FA) Ras PF00071.22 VDK89194.1 - 5.1e-55 185.5 0.0 6.2e-55 185.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDK89194.1 - 9.7e-18 64.5 0.0 1.8e-17 63.6 0.0 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK89194.1 - 2.1e-10 40.3 0.0 2.7e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 VDK89194.1 - 4.3e-05 23.4 1.9 0.00029 20.7 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 VDK89194.1 - 8.3e-05 22.2 0.0 0.00043 19.9 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 VDK89194.1 - 0.00016 21.7 0.0 0.063 13.2 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 VDK89194.1 - 0.00098 19.2 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2075 PF09848.9 VDK89194.1 - 0.0064 15.8 0.2 0.79 8.9 0.2 2.1 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) FeoB_N PF02421.18 VDK89194.1 - 0.026 14.1 0.1 0.054 13.0 0.1 1.6 1 1 0 1 1 1 0 Ferrous iron transport protein B G-alpha PF00503.20 VDK89194.1 - 0.06 12.5 1.4 0.4 9.8 0.2 2.2 1 1 2 3 3 3 0 G-protein alpha subunit DUF1366 PF07104.11 VDK89194.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) zf-CGNR PF11706.8 VDK89194.1 - 1.3 8.9 4.9 19 5.2 0.1 2.4 2 0 0 2 2 2 0 CGNR zinc finger Sporozoite_P67 PF05642.11 VDK89195.1 - 0.033 12.3 8.4 0.033 12.3 8.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 VDK89195.1 - 0.079 11.2 15.0 0.08 11.2 15.0 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 VDK89195.1 - 0.083 11.2 11.4 0.082 11.2 11.4 1.0 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 VDK89195.1 - 0.17 11.1 25.1 0.21 10.9 25.1 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4637 PF15470.6 VDK89195.1 - 0.58 9.9 6.0 0.62 9.8 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CobT PF06213.12 VDK89195.1 - 0.64 9.4 11.8 0.69 9.3 11.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mpp10 PF04006.12 VDK89195.1 - 0.71 8.2 11.7 0.78 8.1 11.7 1.0 1 0 0 1 1 1 0 Mpp10 protein SDA1 PF05285.12 VDK89195.1 - 0.82 9.0 16.5 0.85 9.0 16.5 1.0 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 VDK89195.1 - 1.8 7.8 13.4 1.9 7.8 13.4 1.0 1 0 0 1 1 1 0 BUD22 DUF2457 PF10446.9 VDK89195.1 - 2.6 7.1 34.8 3 6.9 34.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Roughex PF06020.11 VDK89195.1 - 3.1 6.8 15.4 3.7 6.6 15.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein TFB6 PF17110.5 VDK89195.1 - 3.7 7.3 9.0 4.5 7.0 9.0 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH IBR PF01485.21 VDK89196.1 - 1.3e-18 67.0 40.8 3.1e-13 49.7 7.1 3.9 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 VDK89196.1 - 1.2 9.0 41.8 0.079 12.9 11.4 4.9 3 2 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) eIF-5_eIF-2B PF01873.17 VDK89198.1 - 7.7e-42 141.9 0.5 1.1e-41 141.4 0.5 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Elf1 PF05129.13 VDK89198.1 - 0.067 13.2 3.0 0.2 11.7 3.0 1.8 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DNA_pol_B_N PF18094.1 VDK89198.1 - 0.13 12.8 0.2 0.31 11.6 0.2 1.7 1 1 0 1 1 1 0 DNA polymerase beta N-terminal domain DTW PF03942.15 VDK89200.1 - 1.8e-16 60.4 0.0 2.8e-11 43.5 0.0 2.2 1 1 1 2 2 2 2 DTW domain DUF2797 PF10977.8 VDK89200.1 - 0.01 15.7 0.2 0.014 15.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) zf-B_box PF00643.24 VDK89200.1 - 0.089 13.0 2.3 0.14 12.3 2.3 1.3 1 0 0 1 1 1 0 B-box zinc finger zf_UBZ PF18439.1 VDK89200.1 - 1.3 8.7 5.7 3.8 7.2 0.1 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Peptidase_M56 PF05569.11 VDK89202.1 - 0.00059 19.1 0.4 0.00063 19.0 0.4 1.1 1 0 0 1 1 1 1 BlaR1 peptidase M56 ATG27 PF09451.10 VDK89202.1 - 0.17 11.7 0.0 0.21 11.4 0.0 1.1 1 0 0 1 1 1 0 Autophagy-related protein 27 AAA_12 PF13087.6 VDK89206.1 - 3.9e-54 183.3 2.9 7.4e-54 182.4 0.5 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 VDK89206.1 - 1.4e-38 133.2 0.7 4.6e-18 66.0 0.0 2.6 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 VDK89206.1 - 1.4e-13 51.0 0.0 1.3e-12 47.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 VDK89206.1 - 2.3e-10 41.0 0.0 7.1e-10 39.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 VDK89206.1 - 2.9e-07 30.5 0.2 0.0067 16.2 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PIF1 PF05970.14 VDK89206.1 - 8.7e-07 28.4 0.1 0.00037 19.8 0.0 2.3 2 0 0 2 2 2 2 PIF1-like helicase Helicase_RecD PF05127.14 VDK89206.1 - 9.6e-06 25.6 0.3 0.00014 21.7 0.1 2.7 2 1 0 2 2 2 1 Helicase UvrD-helicase PF00580.21 VDK89206.1 - 1.1e-05 25.1 0.1 2.7e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 VDK89206.1 - 1.1e-05 25.3 0.1 3.1e-05 23.8 0.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 VDK89206.1 - 3.5e-05 23.9 0.3 0.0002 21.4 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 VDK89206.1 - 5.3e-05 23.5 0.0 0.00047 20.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Flavi_DEAD PF07652.14 VDK89206.1 - 5.7e-05 23.1 0.1 0.00019 21.4 0.1 1.8 2 0 0 2 2 1 1 Flavivirus DEAD domain PhoH PF02562.16 VDK89206.1 - 0.00022 20.8 0.1 0.011 15.2 0.0 3.0 2 1 1 3 3 3 1 PhoH-like protein AAA_16 PF13191.6 VDK89206.1 - 0.00061 20.2 0.0 0.0021 18.5 0.0 1.9 2 0 0 2 2 1 1 AAA ATPase domain AAA PF00004.29 VDK89206.1 - 0.0016 18.8 0.9 0.0086 16.5 0.3 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 VDK89206.1 - 0.0056 15.8 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein Rad17 PF03215.15 VDK89206.1 - 0.0057 16.6 0.2 0.024 14.6 0.1 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain ATPase_2 PF01637.18 VDK89206.1 - 0.0077 16.2 0.1 0.027 14.4 0.0 2.0 2 1 0 2 2 1 1 ATPase domain predominantly from Archaea AAA_35 PF14516.6 VDK89206.1 - 0.013 14.4 0.0 0.027 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain GARS_N PF02844.15 VDK89206.1 - 0.017 15.9 0.2 0.078 13.8 0.1 2.3 2 0 0 2 2 1 0 Phosphoribosylglycinamide synthetase, N domain KTI12 PF08433.10 VDK89206.1 - 0.017 14.6 0.6 0.11 11.9 0.0 2.5 3 1 0 3 3 3 0 Chromatin associated protein KTI12 AAA_7 PF12775.7 VDK89206.1 - 0.018 14.5 0.0 0.044 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 VDK89206.1 - 0.019 14.2 0.4 0.054 12.7 0.1 2.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 VDK89206.1 - 0.024 14.4 0.0 0.078 12.7 0.0 1.8 2 0 0 2 2 1 0 IstB-like ATP binding protein UvrD_C_2 PF13538.6 VDK89206.1 - 0.025 14.4 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_24 PF13479.6 VDK89206.1 - 0.027 14.2 0.2 0.5 10.1 0.1 2.8 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 VDK89206.1 - 0.046 13.3 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 VDK89206.1 - 0.051 14.1 0.3 0.22 12.1 0.3 2.3 1 1 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 VDK89206.1 - 0.054 12.4 0.0 0.14 11.0 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain RuvB_N PF05496.12 VDK89206.1 - 0.057 13.2 0.1 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain SRP54 PF00448.22 VDK89206.1 - 0.1 12.2 0.0 0.28 10.8 0.0 1.8 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain zf-C3HC4_3 PF13920.6 VDK89207.1 - 6.4e-15 54.8 9.9 1.5e-14 53.6 9.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDK89207.1 - 6.6e-07 29.1 10.8 1.6e-06 27.9 10.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 VDK89207.1 - 5.8e-05 23.4 12.5 5.8e-05 23.4 12.5 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDK89207.1 - 0.0046 16.8 11.5 0.013 15.4 11.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDK89207.1 - 0.019 14.9 10.6 0.019 14.9 10.6 2.0 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 VDK89207.1 - 0.14 11.9 4.7 0.41 10.4 2.4 2.6 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 VDK89207.1 - 0.27 11.1 8.9 0.67 9.8 8.9 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 VDK89207.1 - 1.5 8.9 8.8 27 4.9 5.1 2.8 2 0 0 2 2 2 0 RING-type zinc-finger 7tm_1 PF00001.21 VDK89208.1 - 1.8e-52 178.3 12.1 2.2e-52 178.0 12.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDK89208.1 - 3e-08 33.4 11.6 0.00014 21.3 2.6 2.0 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 VDK89208.1 - 0.00076 19.3 6.1 0.026 14.3 0.7 2.5 2 2 0 2 2 2 2 Olfactory receptor 7TM_GPCR_Srx PF10328.9 VDK89208.1 - 0.0038 16.9 4.7 0.0038 16.9 4.7 2.1 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Virul_fac_BrkB PF03631.15 VDK89208.1 - 0.023 14.3 0.7 0.023 14.3 0.7 1.7 2 0 0 2 2 2 0 Virulence factor BrkB DUF1218 PF06749.12 VDK89208.1 - 1.8 9.2 9.6 2.4 8.7 0.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) Pkinase PF00069.25 VDK89209.1 - 3e-38 131.7 0.0 9.3e-38 130.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89209.1 - 5.4e-25 88.1 0.0 5.3e-23 81.6 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1922 PF09082.10 VDK89209.1 - 0.045 14.0 0.2 0.11 12.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) Homeobox_KN PF05920.11 VDK89212.1 - 7e-08 32.3 0.1 1.5e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain Acyltransf_C PF16076.5 VDK89216.1 - 1e-09 38.4 0.4 2.1e-09 37.4 0.4 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 VDK89216.1 - 4.4e-06 26.3 0.0 8.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase zf-C2H2_4 PF13894.6 VDK89217.1 - 1.4e-14 53.5 19.5 0.0011 19.6 0.0 5.0 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK89217.1 - 7.5e-14 51.3 19.9 0.0019 18.6 1.0 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 VDK89217.1 - 1.7e-06 28.2 9.4 0.054 13.8 0.2 4.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK89217.1 - 5.7e-05 23.4 17.6 3 8.3 0.1 5.4 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 VDK89217.1 - 5.7e-05 22.8 2.0 0.71 9.7 0.1 3.9 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 VDK89217.1 - 0.00048 20.0 19.0 0.0052 16.8 0.7 4.8 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 VDK89217.1 - 0.0014 18.9 6.4 0.027 14.8 0.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 VDK89217.1 - 0.0016 18.6 1.6 0.0038 17.4 1.6 1.5 1 0 0 1 1 1 1 Aberrant zinc-finger Elf1 PF05129.13 VDK89217.1 - 0.3 11.2 5.1 0.36 10.9 0.3 3.1 3 1 0 4 4 4 0 Transcription elongation factor Elf1 like zf-C2H2_2 PF12756.7 VDK89217.1 - 1.1 9.6 13.7 33 4.9 0.6 4.2 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 VDK89218.1 - 1.1e-14 53.8 19.5 0.0011 19.7 0.0 5.0 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK89218.1 - 6e-14 51.6 19.9 0.0018 18.6 1.0 5.0 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 VDK89218.1 - 1.4e-06 28.5 9.4 0.051 13.9 0.2 4.5 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDK89218.1 - 4.3e-05 23.7 17.6 2.9 8.4 0.1 5.5 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 VDK89218.1 - 4.7e-05 23.1 2.0 0.67 9.8 0.1 3.9 4 0 0 4 4 4 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 VDK89218.1 - 0.00038 20.4 19.0 0.0049 16.8 0.7 4.8 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 VDK89218.1 - 0.0012 19.1 6.5 0.025 14.9 0.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 VDK89218.1 - 0.0015 18.7 1.6 0.0035 17.5 1.6 1.5 1 0 0 1 1 1 1 Aberrant zinc-finger Elf1 PF05129.13 VDK89218.1 - 0.28 11.3 5.2 0.72 9.9 1.5 3.1 3 1 0 3 3 3 0 Transcription elongation factor Elf1 like zf-C2H2_2 PF12756.7 VDK89218.1 - 0.94 9.8 13.7 32 4.9 0.7 4.1 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Acyltransferase PF01553.21 VDK89219.1 - 3.3e-06 26.8 0.0 7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 VDK89219.1 - 0.034 14.2 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 Acyltransferase C-terminus 7tm_1 PF00001.21 VDK89223.1 - 1.3e-08 34.5 3.8 1.6e-08 34.2 3.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 VDK89223.1 - 2e-05 24.0 6.3 2.2e-05 23.9 6.3 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srsx PF10320.9 VDK89223.1 - 0.028 13.8 9.1 0.063 12.6 8.4 1.8 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srsx TMEM154 PF15102.6 VDK89223.1 - 9.2 6.2 8.3 0.51 10.2 0.2 2.0 1 1 1 2 2 2 0 TMEM154 protein family SNF PF00209.18 VDK89224.1 - 1.1e-143 479.7 26.4 2.8e-142 475.1 26.4 2.0 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family PgaD PF13994.6 VDK89224.1 - 1.6 8.8 6.0 5.6 7.0 6.0 1.9 1 0 0 1 1 1 0 PgaD-like protein Neur_chan_LBD PF02931.23 VDK89227.1 - 1.5e-39 135.7 0.1 2.4e-39 135.0 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK89227.1 - 2e-14 54.3 0.0 3.1e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_memb PF02932.16 VDK89228.1 - 2.3e-32 112.9 4.6 3.5e-30 105.8 0.9 2.0 1 1 1 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF3246 PF11596.8 VDK89229.1 - 0.069 12.6 15.1 0.11 12.0 15.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) DSPc PF00782.20 VDK89232.1 - 1e-34 119.2 0.1 2e-34 118.3 0.0 1.5 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDK89232.1 - 0.00012 21.7 0.0 0.00022 20.9 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 VDK89232.1 - 0.00076 19.6 0.0 0.0013 18.9 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPn PF14671.6 VDK89232.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half C2 PF00168.30 VDK89233.1 - 4.7e-56 187.4 0.5 3.2e-20 72.3 0.0 3.3 3 0 0 3 3 3 3 C2 domain DOCK-C2 PF14429.6 VDK89233.1 - 0.0073 16.1 0.0 2.1 8.1 0.0 2.5 2 0 0 2 2 2 2 C2 domain in Dock180 and Zizimin proteins DSPc PF00782.20 VDK89236.1 - 6.9e-18 64.7 0.0 1.1e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain TIM PF00121.18 VDK89236.1 - 0.004 16.6 0.0 0.006 16.0 0.0 1.2 1 0 0 1 1 1 1 Triosephosphate isomerase Y_phosphatase3 PF13350.6 VDK89236.1 - 0.038 14.0 0.0 0.046 13.7 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 VDK89236.1 - 0.06 12.9 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Sec61_beta PF03911.16 VDK89238.1 - 2.3e-20 72.4 0.1 2.8e-20 72.1 0.1 1.1 1 0 0 1 1 1 1 Sec61beta family MCU PF04678.13 VDK89239.1 - 0.35 11.0 2.2 0.32 11.1 0.3 1.8 1 1 0 2 2 2 0 Mitochondrial calcium uniporter Pkinase PF00069.25 VDK89241.1 - 2.7e-38 131.8 0.1 3.2e-38 131.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89241.1 - 2.5e-17 63.0 0.0 3e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase POR PF01558.18 VDK89241.1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase FTA2 PF13095.6 VDK89241.1 - 0.069 12.8 0.1 0.71 9.5 0.1 2.0 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Macoilin PF09726.9 VDK89242.1 - 0.016 13.8 4.3 0.018 13.6 4.3 1.0 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 VDK89242.1 - 0.21 9.9 5.4 0.22 9.9 5.4 1.1 1 0 0 1 1 1 0 Menin Orf78 PF06024.12 VDK89242.1 - 2.8 8.3 4.8 5.7 7.3 4.7 1.7 1 1 0 1 1 1 0 Orf78 (ac78) LBP_BPI_CETP_C PF02886.17 VDK89252.1 - 2.6e-15 56.5 0.0 3.6e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 VDK89252.1 - 0.0047 16.5 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain 7tm_1 PF00001.21 VDK89253.1 - 2.8e-05 23.6 0.3 3.4e-05 23.3 0.3 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 VDK89253.1 - 0.0083 15.3 0.1 0.0096 15.1 0.1 1.0 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor MOLO1 PF17175.4 VDK89255.1 - 3.2e-13 49.9 0.0 3.6e-06 27.1 0.1 2.5 1 1 1 2 2 2 2 Modulator of levamisole receptor-1 TPM_phosphatase PF04536.14 VDK89255.1 - 0.0016 18.6 0.0 0.0023 18.1 0.0 1.3 1 0 0 1 1 1 1 TPM domain EphA2_TM PF14575.6 VDK89255.1 - 0.054 14.4 0.1 0.11 13.3 0.1 1.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DHHC PF01529.20 VDK89256.1 - 1.4e-26 93.2 14.2 1.4e-26 93.2 14.2 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Aminotran_1_2 PF00155.21 VDK89259.1 - 1.4e-63 215.2 0.0 1.6e-63 215.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 VDK89259.1 - 4.9e-06 26.1 0.0 7.3e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 VDK89259.1 - 0.00038 19.1 0.0 0.00063 18.4 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 VDK89259.1 - 0.0011 18.0 0.0 0.0017 17.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase_Tyr PF07714.17 VDK89262.1 - 4.8e-87 291.5 0.0 6.4e-87 291.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK89262.1 - 4.8e-42 144.2 0.0 6.7e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDK89262.1 - 4.1e-23 81.3 0.0 8.8e-23 80.2 0.0 1.6 1 0 0 1 1 1 1 SH2 domain Kinase-like PF14531.6 VDK89262.1 - 0.0074 15.6 0.0 0.057 12.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like NHL PF01436.21 VDK89262.1 - 0.056 13.5 1.2 0.39 10.9 0.1 2.7 2 0 0 2 2 2 0 NHL repeat Pkinase_fungal PF17667.1 VDK89262.1 - 0.12 11.1 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Myotub-related PF06602.14 VDK89263.1 - 9.1e-48 163.0 1.7 3.9e-39 134.6 0.4 2.2 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain 3-PAP PF12578.8 VDK89263.1 - 3.2e-05 23.7 0.0 0.00011 22.0 0.0 1.8 1 0 0 1 1 1 1 Myotubularin-associated protein Baculo_11_kDa PF06143.11 VDK89273.1 - 0.041 13.4 0.2 0.062 12.9 0.2 1.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family HemY_N PF07219.13 VDK89273.1 - 0.17 12.1 0.3 0.24 11.6 0.3 1.1 1 0 0 1 1 1 0 HemY protein N-terminus SH3_1 PF00018.28 VDK89275.1 - 4e-15 55.2 0.1 6.2e-15 54.5 0.1 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 VDK89275.1 - 1.2e-13 50.7 0.1 2.4e-13 49.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 VDK89275.1 - 0.0012 18.5 0.0 0.0029 17.2 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain zf-H2C2_2 PF13465.6 VDK89278.1 - 2e-16 59.6 20.3 2.4e-07 30.9 2.6 3.5 3 0 0 3 3 3 3 Zinc-finger double domain Homeodomain PF00046.29 VDK89278.1 - 4.4e-16 58.5 1.3 1.3e-15 57.0 0.4 2.1 2 0 0 2 2 2 1 Homeodomain zf-C2H2 PF00096.26 VDK89278.1 - 4.3e-09 36.3 26.0 0.0031 17.9 7.3 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK89278.1 - 0.00027 21.5 24.2 0.14 13.1 0.5 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 VDK89278.1 - 0.00061 19.7 24.0 0.0021 18.0 1.2 3.7 3 0 0 3 3 3 2 C2H2-type zinc finger Homeobox_KN PF05920.11 VDK89278.1 - 0.0011 18.9 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain zf-MYST PF17772.1 VDK89278.1 - 0.092 12.4 10.4 1.7 8.3 0.2 3.5 3 0 0 3 3 3 0 MYST family zinc finger domain zf-C2H2_jaz PF12171.8 VDK89278.1 - 0.19 12.1 18.1 0.17 12.2 0.8 3.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 VDK89278.1 - 0.26 11.1 4.0 7.3 6.5 0.8 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type Cytochrom_B559 PF00283.19 VDK89278.1 - 0.27 10.7 2.5 0.64 9.5 2.5 1.6 1 0 0 1 1 1 0 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits zf-met PF12874.7 VDK89278.1 - 0.37 11.2 17.8 1.6 9.2 2.8 3.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF2197 PF09963.9 VDK89278.1 - 0.52 10.6 2.3 1.3 9.3 0.6 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-C2H2_8 PF15909.5 VDK89278.1 - 2.1 8.7 8.9 5 7.5 7.5 2.2 1 1 1 2 2 2 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 VDK89278.1 - 2.2 9.1 8.1 77 4.1 8.1 2.5 1 1 0 1 1 1 0 zinc-ribbon family zf_UBZ PF18439.1 VDK89278.1 - 2.4 7.8 10.7 11 5.7 0.1 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2 PF00096.26 VDK89280.1 - 3.9e-06 27.0 4.8 6.5e-06 26.3 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK89280.1 - 6.6e-05 23.2 11.8 0.0046 17.3 0.5 2.5 2 1 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK89280.1 - 0.0033 18.1 4.6 0.0063 17.3 4.6 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK89280.1 - 0.13 12.0 8.4 0.91 9.3 8.4 2.2 1 1 0 1 1 1 0 C2H2-type zinc-finger domain Carbam_trans_C PF16861.5 VDK89284.1 - 0.093 12.3 4.5 0.029 13.9 1.5 1.6 2 0 0 2 2 2 0 Carbamoyltransferase C-terminus Uso1_p115_C PF04871.13 VDK89284.1 - 1.9 8.9 19.6 1.3 9.4 0.2 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region EFF-AFF PF14884.6 VDK89285.1 - 1.3e-83 281.2 3.5 3.5e-83 279.7 3.5 1.6 1 1 0 1 1 1 1 Type I membrane glycoproteins cell-cell fusogen MHYT PF03707.16 VDK89286.1 - 0.091 12.9 0.1 0.17 12.1 0.1 1.5 1 1 0 1 1 1 0 Bacterial signalling protein N terminal repeat RCR PF12273.8 VDK89286.1 - 0.14 12.9 0.0 0.16 12.6 0.0 1.2 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red Prothymosin PF03247.14 VDK89290.1 - 0.14 12.6 4.8 2.3 8.7 0.1 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family Prothymosin PF03247.14 VDK89293.1 - 0.14 12.6 4.8 2.3 8.7 0.1 2.1 2 0 0 2 2 2 0 Prothymosin/parathymosin family Epimerase PF01370.21 VDK89294.1 - 5.1e-16 58.9 0.0 7.6e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 VDK89294.1 - 1.6e-15 56.9 0.0 2.1e-15 56.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 VDK89294.1 - 1.7e-12 47.0 0.0 2.3e-08 33.5 0.0 2.3 2 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 VDK89294.1 - 2.6e-06 27.5 0.0 4e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 VDK89294.1 - 8.1e-05 21.9 0.0 0.00045 19.4 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 VDK89294.1 - 0.0001 21.8 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 VDK89294.1 - 0.13 11.3 0.0 0.26 10.4 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NmrA PF05368.13 VDK89294.1 - 0.17 11.5 0.0 0.24 10.9 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family Glyco_transf_10 PF00852.19 VDK89295.1 - 1.3e-49 168.3 5.7 2.1e-49 167.6 5.7 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 VDK89295.1 - 8.3e-21 74.5 0.9 8.3e-21 74.5 0.9 2.5 2 1 1 3 3 3 1 Fucosyltransferase, N-terminal Hormone_3 PF00159.18 VDK89295.1 - 0.0042 17.1 1.3 3.2 7.9 0.0 2.8 3 0 0 3 3 3 2 Pancreatic hormone peptide TPR_19 PF14559.6 VDK89296.1 - 6.3e-08 33.0 2.3 7.2e-06 26.4 0.0 3.8 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDK89296.1 - 6.7e-05 22.7 0.1 0.0054 16.8 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDK89296.1 - 0.00066 19.7 0.2 0.012 15.8 0.1 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDK89296.1 - 0.0024 18.1 1.1 0.063 13.6 0.1 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 VDK89296.1 - 0.0047 16.7 0.4 2.7 7.9 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK89296.1 - 0.012 15.8 1.7 0.23 11.7 0.1 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SURF2 PF05477.11 VDK89299.1 - 4.9e-07 29.7 7.9 1.2e-06 28.4 7.9 1.6 1 1 0 1 1 1 1 Surfeit locus protein 2 (SURF2) SLATT_fungal PF18142.1 VDK89299.1 - 0.25 11.3 1.3 4.3 7.3 1.3 2.2 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain eIF-3c_N PF05470.12 VDK89300.1 - 1.4e-200 667.6 46.8 1.1e-199 664.6 46.8 2.2 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 VDK89300.1 - 1.5e-16 60.8 2.4 3.2e-16 59.7 0.4 2.5 2 0 0 2 2 2 1 PCI domain Cir_Bir_Yir PF06022.11 VDK89300.1 - 0.0015 18.1 0.5 0.0042 16.6 0.5 1.8 1 0 0 1 1 1 1 Plasmodium variant antigen protein Cir/Yir/Bir Presenilin PF01080.17 VDK89300.1 - 4 6.1 11.5 14 4.3 11.5 2.0 1 0 0 1 1 1 0 Presenilin RRN9 PF10680.9 VDK89300.1 - 5.8 7.3 6.7 4.6 7.6 1.3 3.2 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor Med15 PF09606.10 VDK89307.1 - 2e-42 145.9 3.3 1.8e-19 70.0 0.0 5.2 3 2 3 6 6 6 4 ARC105 or Med15 subunit of Mediator complex non-fungal KIX_2 PF16987.5 VDK89307.1 - 0.00012 21.9 0.0 0.001 19.0 0.0 2.4 2 0 0 2 2 2 1 KIX domain KIX PF02172.16 VDK89307.1 - 0.12 12.7 0.3 0.44 10.8 0.3 2.0 1 1 0 1 1 1 0 KIX domain DEAD PF00270.29 VDK89308.1 - 1.1e-51 175.1 0.0 4.2e-51 173.2 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK89308.1 - 1.9e-25 89.4 0.0 1.1e-24 86.9 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 VDK89308.1 - 0.0073 16.3 0.1 0.026 14.5 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 VDK89308.1 - 0.0086 15.4 0.0 0.0086 15.4 0.0 2.2 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit YSIRK_signal PF04650.17 VDK89308.1 - 0.14 12.0 0.2 0.31 10.9 0.2 1.6 1 0 0 1 1 1 0 YSIRK type signal peptide Innexin PF00876.18 VDK89313.1 - 2.5e-108 362.5 14.5 2.9e-107 359.0 14.5 1.9 1 1 0 1 1 1 1 Innexin Pkinase PF00069.25 VDK89315.1 - 1.8e-18 66.9 0.1 2.5e-18 66.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89315.1 - 7e-15 55.0 0.1 1e-14 54.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK89316.1 - 8.7e-19 67.9 0.0 1e-18 67.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89316.1 - 3e-10 39.8 0.0 3.7e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase BIRC6 PF12356.8 VDK89316.1 - 0.0047 16.4 0.1 0.0062 16.0 0.1 1.1 1 0 0 1 1 1 1 Baculoviral IAP repeat-containing protein 6 Lectin_C PF00059.21 VDK89318.1 - 1.1e-10 42.2 3.4 1.5e-10 41.8 3.4 1.2 1 0 0 1 1 1 1 Lectin C-type domain zf-H2C2_2 PF13465.6 VDK89322.1 - 0.0032 17.8 1.9 0.0032 17.8 1.9 2.2 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 VDK89322.1 - 0.02 15.3 1.0 0.02 15.3 1.0 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK89322.1 - 0.022 15.6 1.6 0.022 15.6 1.6 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 VDK89323.1 - 2.2e-08 34.1 16.6 0.0039 17.6 0.4 4.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDK89323.1 - 1.3e-07 31.8 17.7 0.0021 18.7 0.5 4.5 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_11 PF16622.5 VDK89323.1 - 5.7e-07 29.2 7.6 0.033 14.0 0.9 3.7 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 VDK89323.1 - 0.035 14.4 5.0 0.37 11.1 4.3 2.9 1 1 0 1 1 1 0 C2H2-type zinc ribbon zinc_ribbon_15 PF17032.5 VDK89323.1 - 0.15 12.8 4.7 6.1 7.7 4.5 2.7 1 1 0 1 1 1 0 zinc-ribbon family C1_4 PF07975.12 VDK89323.1 - 0.22 11.8 6.2 11 6.3 4.9 3.2 1 1 1 2 2 2 0 TFIIH C1-like domain zf-Di19 PF05605.12 VDK89323.1 - 0.29 11.5 2.6 1 9.7 2.6 2.1 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 VDK89323.1 - 0.37 11.3 0.1 0.37 11.3 0.1 4.6 6 0 0 6 6 5 0 Zinc-finger double domain RNA_POL_M_15KD PF02150.16 VDK89323.1 - 0.53 10.2 2.8 1.3 9.0 0.1 2.7 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit zf-C2H2_3rep PF18868.1 VDK89323.1 - 0.92 10.2 6.1 4.6 7.9 0.3 3.4 1 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats ATP-synt_E_2 PF08112.11 VDK89323.1 - 1.5 9.2 3.5 1 9.7 1.2 1.9 2 0 0 2 2 1 0 ATP synthase epsilon subunit zf-C2H2_6 PF13912.6 VDK89323.1 - 1.6 8.8 7.6 5.7 7.1 0.0 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 VDK89323.1 - 3 8.2 12.5 13 6.2 0.1 3.8 2 1 2 4 4 3 0 C2H2 type zinc-finger (2 copies) Barttin PF15462.6 VDK89325.1 - 0.41 10.4 8.4 0.099 12.4 4.9 1.7 1 1 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) SH3_9 PF14604.6 VDK89326.1 - 4.5e-08 32.8 0.1 3.2e-07 30.1 0.1 2.3 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDK89326.1 - 2.5e-07 30.2 0.0 6.6e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 VDK89326.1 - 0.0031 17.1 0.0 0.0065 16.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain LprI PF07007.12 VDK89326.1 - 0.021 15.5 1.4 0.56 10.9 0.0 2.7 2 1 0 2 2 2 0 Lysozyme inhibitor LprI SlyX PF04102.12 VDK89326.1 - 0.99 10.1 8.2 1.4 9.6 1.2 3.4 3 0 0 3 3 3 0 SlyX G-patch PF01585.23 VDK89328.1 - 9.5e-14 51.0 0.6 1.6e-13 50.3 0.6 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 VDK89328.1 - 0.00023 21.2 0.3 0.00023 21.2 0.3 2.0 2 0 0 2 2 2 1 G-patch domain SpvB PF03534.13 VDK89328.1 - 0.027 13.7 0.2 0.03 13.5 0.2 1.1 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein Metallophos PF00149.28 VDK89329.1 - 7.6e-25 88.6 2.8 3.8e-12 47.1 0.1 3.1 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 VDK89329.1 - 8.7e-16 58.6 0.0 4.1e-08 33.6 0.0 2.7 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Thioredoxin PF00085.20 VDK89334.1 - 2.3e-31 107.9 0.1 6.9e-29 99.9 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 VDK89334.1 - 5.2e-26 91.7 4.1 1e-21 77.7 1.2 2.9 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 VDK89334.1 - 1.4e-06 28.7 1.9 5.2e-06 26.9 0.2 2.7 3 1 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 VDK89334.1 - 7e-06 26.3 1.8 0.00071 19.8 0.0 2.9 2 1 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 VDK89334.1 - 1.8e-05 24.7 0.2 0.00099 19.0 0.0 2.3 2 0 0 2 2 2 1 AhpC/TSA family OST3_OST6 PF04756.13 VDK89334.1 - 0.00029 20.3 0.4 0.0086 15.5 0.0 2.1 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 VDK89334.1 - 0.0006 19.5 0.3 0.0045 16.7 0.0 2.1 2 0 0 2 2 2 1 Redoxin Thioredoxin_7 PF13899.6 VDK89334.1 - 0.00075 19.6 0.1 0.002 18.3 0.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like Glutaredoxin PF00462.24 VDK89334.1 - 0.0014 18.8 0.2 0.0056 16.9 0.0 2.1 2 0 0 2 2 2 1 Glutaredoxin TraF PF13728.6 VDK89334.1 - 0.002 18.0 0.1 0.067 13.0 0.0 2.3 2 0 0 2 2 2 1 F plasmid transfer operon protein ERp29_N PF07912.13 VDK89334.1 - 0.0072 16.5 0.6 1.2 9.3 0.0 2.3 2 0 0 2 2 2 1 ERp29, N-terminal domain Thioredoxin_9 PF14595.6 VDK89334.1 - 0.1 12.4 0.7 0.32 10.8 0.1 2.2 2 1 0 2 2 2 0 Thioredoxin Rho_GDI PF02115.17 VDK89335.1 - 1e-60 204.9 0.1 1.2e-60 204.6 0.1 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor SH3_5 PF08460.10 VDK89335.1 - 0.00057 19.9 0.1 0.0011 19.0 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain ESSS PF10183.9 VDK89337.1 - 5.6e-11 42.6 0.2 8.7e-11 42.0 0.2 1.5 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Gpi1 PF05024.15 VDK89340.1 - 6.3e-50 169.9 13.5 1.1e-49 169.1 13.5 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Rhodanese PF00581.20 VDK89340.1 - 2e-07 31.5 0.0 3.6e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Phage_holin_3_6 PF07332.11 VDK89340.1 - 2.7 8.1 5.2 0.96 9.5 0.1 2.5 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III PID PF00640.23 VDK89347.1 - 1e-16 61.2 0.0 1.8e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) PTB PF08416.13 VDK89347.1 - 3.1e-07 30.6 0.0 4.7e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine-binding domain PID_2 PF14719.6 VDK89347.1 - 0.0067 16.3 0.0 0.0095 15.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotyrosine interaction domain (PTB/PID) DUF1765 PF08578.10 VDK89347.1 - 0.059 13.8 0.2 0.091 13.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1765) YhhN PF07947.14 VDK89348.1 - 3.3e-27 95.3 15.6 4.3e-27 94.9 15.6 1.1 1 0 0 1 1 1 1 YhhN family Ribosomal_S8e PF01201.22 VDK89351.1 - 4.9e-23 81.8 0.1 5.7e-23 81.6 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e MCM PF00493.23 VDK89352.1 - 8.7e-97 322.6 0.0 1.4e-96 321.9 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 VDK89352.1 - 1.7e-32 111.9 0.1 2.2e-31 108.3 0.0 2.3 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 VDK89352.1 - 1.3e-22 80.0 2.8 2.8e-22 78.9 2.8 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 VDK89352.1 - 2.7e-08 34.3 0.1 9.1e-08 32.6 0.1 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 VDK89352.1 - 4.5e-07 29.5 0.0 2.2e-06 27.2 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 VDK89352.1 - 0.0046 16.8 0.0 0.017 15.0 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 VDK89352.1 - 0.0062 16.5 0.0 0.023 14.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 VDK89352.1 - 0.073 12.8 0.0 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Integrase_Zn PF02022.19 VDK89352.1 - 0.17 11.9 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Integrase Zinc binding domain PGA2 PF07543.12 VDK89352.1 - 0.25 11.3 3.2 0.5 10.4 3.2 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 F-box PF00646.33 VDK89353.1 - 0.0065 16.3 0.2 0.013 15.4 0.2 1.5 1 0 0 1 1 1 1 F-box domain Neur_chan_LBD PF02931.23 VDK89356.1 - 3.1e-13 49.7 0.5 4.5e-13 49.2 0.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Vps5 PF09325.10 VDK89358.1 - 0.057 13.0 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 Vps5 C terminal like betaPIX_CC PF16523.5 VDK89358.1 - 0.15 11.9 0.3 0.74 9.7 0.1 1.9 1 1 0 2 2 2 0 betaPIX coiled coil RIC1 PF07064.13 VDK89362.1 - 2.9e-37 128.4 2.1 4e-37 128.0 0.4 2.0 2 1 0 2 2 2 1 RIC1 SRA1 PF07304.11 VDK89362.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) Ion_trans_2 PF07885.16 VDK89363.1 - 1.8e-16 59.9 6.5 1.1e-09 38.1 4.0 2.3 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 VDK89363.1 - 0.26 10.5 5.2 0.48 9.6 5.0 1.4 1 1 0 1 1 1 0 Ion transport protein CDC73_N PF16050.5 VDK89373.1 - 1.7e-62 211.4 1.5 1.7e-62 211.4 1.5 1.6 2 0 0 2 2 2 1 Paf1 complex subunit CDC73 N-terminal CDC73_C PF05179.14 VDK89373.1 - 1.4e-49 167.8 0.4 2.3e-49 167.1 0.4 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal UvrA_DNA-bind PF17755.1 VDK89373.1 - 0.077 13.4 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 UvrA DNA-binding domain KAP_NTPase PF07693.14 VDK89374.1 - 3.3e-85 286.2 0.1 4.3e-85 285.8 0.1 1.1 1 0 0 1 1 1 1 KAP family P-loop domain Ank_2 PF12796.7 VDK89374.1 - 1.9e-70 233.5 10.5 2.1e-15 57.0 0.1 6.6 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDK89374.1 - 6.8e-48 160.5 9.7 2.4e-10 40.7 0.1 10.2 3 1 7 11 11 11 9 Ankyrin repeats (many copies) Ank PF00023.30 VDK89374.1 - 2.4e-45 151.0 4.4 0.00011 22.4 0.0 11.5 11 0 0 11 11 11 8 Ankyrin repeat Ank_5 PF13857.6 VDK89374.1 - 3.7e-40 135.5 13.3 4.9e-08 33.1 0.1 8.6 1 1 8 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDK89374.1 - 6.3e-36 118.3 8.4 0.003 17.9 0.1 11.4 11 0 0 11 11 11 9 Ankyrin repeat NACHT PF05729.12 VDK89374.1 - 0.17 11.8 0.1 4.8 7.1 0.0 2.4 2 0 0 2 2 2 0 NACHT domain DUF4293 PF14126.6 VDK89374.1 - 1.4 9.2 13.8 1.8 8.8 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) BTB PF00651.31 VDK89400.1 - 2.1e-06 27.9 1.0 2.4e-06 27.7 0.2 1.5 2 0 0 2 2 2 1 BTB/POZ domain BTB PF00651.31 VDK89401.1 - 1.3e-06 28.6 0.1 2.9e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain DUF1265 PF06887.14 VDK89401.1 - 0.0049 16.8 0.4 0.0096 15.9 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1265) Actin_micro PF17003.5 VDK89402.1 - 5.5e-05 22.5 5.1 0.0029 16.8 1.4 2.3 2 0 0 2 2 2 2 Putative actin-like family PHD PF00628.29 VDK89402.1 - 1.6 8.7 7.4 0.58 10.1 1.9 2.8 2 0 0 2 2 2 0 PHD-finger CYLD_phos_site PF16607.5 VDK89407.1 - 0.0098 15.8 7.3 0.017 14.9 7.3 1.3 1 0 0 1 1 1 1 Phosphorylation region of CYLD, unstructured TIM21 PF08294.11 VDK89407.1 - 0.098 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 TIM21 Pkinase PF00069.25 VDK89410.1 - 5.1e-69 232.6 0.0 7.3e-69 232.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89410.1 - 5.2e-40 137.4 0.0 7.5e-40 136.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 VDK89410.1 - 1.2e-38 131.1 0.2 5e-21 74.7 0.2 2.5 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 VDK89410.1 - 9.2e-08 31.7 0.0 2.7e-07 30.2 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDK89410.1 - 1.2e-05 24.3 0.0 2.2e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Shadoo PF14999.6 VDK89417.1 - 0.013 15.6 3.4 0.018 15.2 3.4 1.2 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective HEV_ORF1 PF02444.16 VDK89417.1 - 0.017 15.7 2.6 0.019 15.5 2.6 1.2 1 0 0 1 1 1 0 Hepatitis E virus ORF-2 (Putative capsid protein) RskA PF10099.9 VDK89417.1 - 0.023 15.0 12.5 0.025 14.9 12.5 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA VirB3 PF05101.13 VDK89417.1 - 0.56 10.5 4.5 0.77 10.0 4.5 1.3 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein Stevor PF17410.2 VDK89417.1 - 1.5 8.3 6.2 1.5 8.3 6.2 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Tic110 PF16940.5 VDK89417.1 - 3.9 5.9 11.2 3.8 5.9 11.2 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter Adeno_PV PF03910.13 VDK89417.1 - 5.3 5.6 10.0 5.9 5.5 10.0 1.1 1 0 0 1 1 1 0 Adenovirus minor core protein PV SNF PF00209.18 VDK89419.1 - 2.8e-181 603.8 35.9 3.6e-181 603.4 35.9 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family Copine PF07002.16 VDK89422.1 - 4.4e-71 238.8 0.0 6.1e-71 238.3 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 VDK89422.1 - 1e-17 64.3 0.0 4.4e-10 39.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 VDK89422.1 - 0.0028 17.8 0.0 0.0054 16.9 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus Somatomedin_B PF01033.17 VDK89426.1 - 7.5e-08 32.7 7.5 7.5e-08 32.7 7.5 3.7 4 0 0 4 4 4 1 Somatomedin B domain TSP_1 PF00090.19 VDK89426.1 - 0.00089 19.4 6.1 0.00089 19.4 6.1 2.4 2 1 0 2 2 2 1 Thrombospondin type 1 domain GF_recep_IV PF14843.6 VDK89426.1 - 0.17 11.7 20.3 0.42 10.4 0.7 2.6 2 0 0 2 2 2 0 Growth factor receptor domain IV PTN_MK_N PF05196.13 VDK89426.1 - 0.3 11.3 14.3 0.027 14.7 8.2 2.5 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, N-terminal domain Claudin_2 PF13903.6 VDK89427.1 - 0.016 14.9 1.0 0.026 14.3 1.0 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Neurensin PF14927.6 VDK89427.1 - 0.052 13.3 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 Neurensin DUF3039 PF11238.8 VDK89427.1 - 0.079 12.7 0.1 0.13 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) RXLR PF16810.5 VDK89427.1 - 0.15 12.5 0.0 0.22 12.0 0.0 1.2 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity WD40 PF00400.32 VDK89429.1 - 2.3e-16 59.9 7.8 7.4e-09 36.1 0.3 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDK89429.1 - 3.2e-08 33.7 0.4 0.00019 21.7 0.1 4.4 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_19 PF14559.6 VDK89429.1 - 0.00052 20.5 0.0 0.004 17.6 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDK89429.1 - 0.0051 16.6 3.6 3.6 7.6 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 VDK89429.1 - 0.014 14.6 0.1 0.024 13.9 0.1 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDK89429.1 - 0.016 15.4 0.2 5.8 7.2 0.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 VDK89429.1 - 0.018 15.4 0.0 0.058 13.8 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDK89429.1 - 0.036 14.7 0.0 5.6 7.8 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribonuc_2-5A PF06479.12 VDK89429.1 - 0.098 12.8 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Ribonuclease 2-5A Ribosomal_L22e PF01776.17 VDK89432.1 - 2e-39 134.3 0.9 2.7e-39 133.9 0.9 1.2 1 0 0 1 1 1 1 Ribosomal L22e protein family TTD PF12148.8 VDK89432.1 - 0.043 13.7 0.1 0.066 13.1 0.1 1.3 1 0 0 1 1 1 0 Tandem tudor domain within UHRF1 ATP-synt_D PF01813.17 VDK89433.1 - 0.027 14.3 0.0 0.03 14.2 0.0 1.1 1 0 0 1 1 1 0 ATP synthase subunit D Inositol_P PF00459.25 VDK89435.1 - 1.5e-32 113.2 0.0 2.3e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family NACHT_N PF17100.5 VDK89436.1 - 0.79 9.5 6.7 0.037 13.9 1.0 1.6 2 0 0 2 2 2 0 N-terminal domain of NWD NACHT-NTPase CBS PF00571.28 VDK89438.1 - 3.5e-18 65.8 7.6 4.2e-08 33.5 0.3 4.4 4 0 0 4 4 4 4 CBS domain OSTbeta PF15048.6 VDK89438.1 - 0.14 12.3 0.7 0.32 11.1 0.2 1.8 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein Pkinase PF00069.25 VDK89446.1 - 1.5e-52 178.5 0.0 2.4e-52 177.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDK89446.1 - 9e-19 67.8 0.0 1.4e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDK89446.1 - 2.3e-08 33.7 0.0 3.1e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 VDK89446.1 - 0.00014 21.3 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TTL PF03133.15 VDK89451.1 - 1.6e-52 178.5 1.9 2.6e-52 177.8 1.9 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Mistic PF11458.8 VDK89451.1 - 0.079 12.9 1.8 1.3 9.0 0.3 2.8 3 0 0 3 3 3 0 Membrane-integrating protein Mistic zf-MYND PF01753.18 VDK89456.1 - 0.00042 20.3 24.3 0.00042 20.3 24.3 3.2 3 0 0 3 3 3 1 MYND finger DUF3135 PF11333.8 VDK89456.1 - 0.039 14.2 0.1 0.093 13.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) TPR_12 PF13424.6 VDK89456.1 - 0.043 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat SET PF00856.28 VDK89456.1 - 0.24 11.8 4.6 1.1 9.6 0.1 2.6 3 0 0 3 3 3 0 SET domain ANAPC4_WD40 PF12894.7 VDK89457.1 - 0.032 14.5 0.0 0.19 12.0 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Jas PF16135.5 VDK89460.1 - 0.03 14.5 0.2 0.095 12.9 0.2 1.8 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling Gly_reductase PF09338.11 VDK89460.1 - 0.082 11.3 0.6 0.12 10.7 0.6 1.2 1 0 0 1 1 1 0 Glycine/sarcosine/betaine reductase component B subunits Dicty_REP PF05086.12 VDK89460.1 - 2.6 5.9 7.4 3.5 5.5 7.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-C2H2 PF00096.26 VDK89461.1 - 2.8e-10 40.1 36.6 0.0014 19.0 4.5 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDK89461.1 - 3.5e-07 30.4 0.7 3.5e-07 30.4 0.7 4.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDK89461.1 - 8.8e-06 26.1 37.3 0.016 16.0 3.1 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_5 PF13909.6 VDK89461.1 - 9.5e-05 22.1 4.7 9.5e-05 22.1 4.7 4.0 3 1 0 3 3 3 1 C2H2-type zinc-finger domain zf-met PF12874.7 VDK89461.1 - 0.015 15.7 1.7 0.015 15.7 1.7 3.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DUF1593 PF07632.11 VDK89461.1 - 0.06 12.8 0.0 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) DUF3306 PF11748.8 VDK89461.1 - 0.69 10.8 4.0 0.6 11.0 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) zf-C2H2_2 PF12756.7 VDK89461.1 - 6.9 7.1 23.6 19 5.7 0.7 3.7 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) LSM PF01423.22 VDK89464.1 - 1.2e-22 79.3 0.4 1.4e-22 79.1 0.4 1.0 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.8 VDK89464.1 - 0.18 11.7 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) EF-hand_13 PF17958.1 VDK89465.1 - 2e-36 123.7 0.1 7.1e-36 121.9 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 VDK89465.1 - 5.7e-18 65.1 3.5 1.3e-14 54.4 0.1 4.6 4 1 1 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 VDK89465.1 - 7.1e-05 22.1 0.3 0.0073 15.8 0.0 3.7 4 0 0 4 4 4 1 EF hand EF-hand_6 PF13405.6 VDK89465.1 - 0.0019 18.0 1.5 0.24 11.4 0.0 4.5 5 0 0 5 5 5 1 EF-hand domain EF-hand_1 PF00036.32 VDK89465.1 - 0.012 15.1 0.8 0.32 10.6 0.0 3.7 5 0 0 5 5 5 0 EF hand DUF4187 PF13821.6 VDK89465.1 - 0.031 14.0 0.7 0.098 12.5 0.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4187) G-alpha PF00503.20 VDK89471.1 - 6e-95 318.4 1.8 7.3e-95 318.1 1.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 VDK89471.1 - 3.1e-12 46.3 0.1 8.6e-12 44.8 0.1 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDK89471.1 - 0.0011 18.4 0.0 0.0017 17.8 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AA_permease PF00324.21 VDK89473.1 - 1e-81 275.0 39.5 3.8e-44 151.1 21.3 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease_N PF08403.10 VDK89473.1 - 9.1e-07 28.3 0.1 3.1e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Amino acid permease N-terminal DDDD PF10161.9 VDK89473.1 - 0.36 10.6 4.3 7.5 6.4 0.1 3.3 2 1 1 3 3 3 0 Putative mitochondrial precursor protein CH PF00307.31 VDK89486.1 - 7.4e-48 161.3 4.5 1.8e-25 89.3 0.1 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain Spectrin PF00435.21 VDK89486.1 - 2.5e-43 146.8 20.9 1.1e-14 54.8 2.9 4.7 4 0 0 4 4 4 4 Spectrin repeat CAMSAP_CH PF11971.8 VDK89486.1 - 6.9e-09 35.4 0.2 3.2e-06 26.9 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain CH_2 PF06294.11 VDK89486.1 - 0.0016 18.5 0.3 4.2 7.6 0.0 3.3 3 0 0 3 3 3 2 CH-like domain in sperm protein DUF4918 PF16265.5 VDK89486.1 - 0.14 11.7 0.1 0.27 10.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4918) DUF4611 PF15387.6 VDK89487.1 - 0.085 13.1 4.2 0.1 12.8 4.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 VDK89487.1 - 0.78 9.0 9.0 0.77 9.0 9.0 1.0 1 0 0 1 1 1 0 NOA36 protein DUF1635 PF07795.11 VDK89488.1 - 0.19 11.6 15.0 0.036 13.9 8.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) NeA_P2 PF12312.8 VDK89489.1 - 0.037 13.5 1.0 0.054 12.9 1.0 1.2 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein PRIMA1 PF16101.5 VDK89489.1 - 0.072 13.1 4.6 0.16 12.0 4.6 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SOG2 PF10428.9 VDK89489.1 - 0.2 10.8 8.9 0.23 10.6 8.9 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein AAA PF00004.29 VDK89492.1 - 1.3e-14 54.8 0.0 2.3e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 VDK89492.1 - 3.3e-13 49.7 0.0 2.5e-11 43.6 0.0 2.3 1 1 1 2 2 2 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 VDK89492.1 - 2.2e-12 47.2 0.6 4.4e-06 27.0 0.0 3.1 2 1 1 3 3 3 2 Replication factor C C-terminal domain AAA_16 PF13191.6 VDK89492.1 - 3.6e-08 34.0 0.0 9.1e-06 26.2 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 VDK89492.1 - 4.1e-08 33.3 0.0 5.9e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 VDK89492.1 - 8.2e-08 32.4 0.0 7.5e-07 29.2 0.0 2.2 1 1 1 2 2 2 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 VDK89492.1 - 8.1e-07 29.0 0.0 2.1e-06 27.6 0.0 1.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 VDK89492.1 - 2.2e-05 24.3 0.0 0.00014 21.6 0.0 2.3 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 VDK89492.1 - 4.3e-05 23.8 0.1 0.081 13.2 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_11 PF13086.6 VDK89492.1 - 0.00014 21.7 0.0 0.00018 21.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 VDK89492.1 - 0.00015 22.3 0.0 0.00029 21.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 VDK89492.1 - 0.00015 22.0 0.0 0.00046 20.5 0.0 1.9 2 0 0 2 2 1 1 AAA C-terminal domain TniB PF05621.11 VDK89492.1 - 0.0003 20.2 0.1 0.92 8.9 0.0 2.6 3 0 0 3 3 3 2 Bacterial TniB protein Mg_chelatase PF01078.21 VDK89492.1 - 0.00072 19.0 0.0 0.027 13.9 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 VDK89492.1 - 0.001 19.4 0.0 0.0032 17.8 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_3 PF07726.11 VDK89492.1 - 0.0013 18.6 0.0 0.0028 17.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 VDK89492.1 - 0.0014 18.6 0.0 0.0041 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 VDK89492.1 - 0.0016 18.2 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 VDK89492.1 - 0.0017 18.3 0.2 0.11 12.4 0.0 2.6 2 1 1 3 3 2 1 NTPase AAA_19 PF13245.6 VDK89492.1 - 0.0019 18.5 0.2 0.016 15.6 0.2 2.3 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 VDK89492.1 - 0.0021 17.9 0.1 0.0034 17.2 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Pombe_5TM PF09437.10 VDK89492.1 - 0.0025 17.5 0.1 0.0046 16.6 0.1 1.5 1 1 0 1 1 1 1 Pombe specific 5TM protein AAA_28 PF13521.6 VDK89492.1 - 0.0026 18.0 0.0 0.0039 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 VDK89492.1 - 0.0036 16.4 0.0 0.0077 15.3 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 VDK89492.1 - 0.006 16.1 0.0 0.0089 15.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 VDK89492.1 - 0.014 14.5 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 VDK89492.1 - 0.015 15.5 0.0 0.024 14.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 VDK89492.1 - 0.022 13.8 0.0 0.1 11.6 0.0 1.9 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 VDK89492.1 - 0.024 14.2 0.1 0.19 11.3 0.0 2.1 1 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 VDK89492.1 - 0.028 14.1 0.0 0.064 13.0 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 VDK89492.1 - 0.031 14.8 0.0 0.05 14.1 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 VDK89492.1 - 0.051 13.3 0.0 0.12 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 VDK89492.1 - 0.11 11.8 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 VDK89492.1 - 0.13 12.2 0.0 0.62 10.0 0.0 2.1 1 1 0 1 1 1 0 NACHT domain ATPase_2 PF01637.18 VDK89492.1 - 0.15 12.0 0.0 0.54 10.1 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 VDK89492.1 - 0.15 12.5 0.1 0.24 11.9 0.1 1.4 1 1 0 1 1 1 0 AAA domain ACBP PF00887.19 VDK89494.1 - 1e-29 102.6 2.2 1.1e-29 102.5 2.2 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 VDK89494.1 - 0.00013 22.4 0.3 0.00037 20.9 0.2 1.7 1 1 1 2 2 2 1 FERM central domain VPR PF00522.18 VDK89494.1 - 0.022 14.8 0.1 0.04 13.9 0.1 1.4 1 1 0 1 1 1 0 VPR/VPX protein SAP18 PF06487.12 VDK89496.1 - 7.5e-40 136.4 0.0 9.6e-40 136.0 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Sec6 PF06046.13 VDK89497.1 - 1.6e-22 79.7 0.9 1.9e-22 79.4 0.9 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec6 MHCassoc_trimer PF08831.10 VDK89497.1 - 0.11 12.5 0.1 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain Transket_pyr PF02779.24 VDK89498.1 - 6.5e-45 153.0 0.0 8.8e-45 152.6 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 VDK89498.1 - 3.1e-39 133.7 0.0 5.4e-39 132.9 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 VDK89498.1 - 6.6e-05 23.2 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II bMG1 PF17970.1 VDK89498.1 - 0.03 14.4 0.0 0.07 13.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG1 domain GntR PF00392.21 VDK89498.1 - 0.053 13.2 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family DEAD PF00270.29 VDK89499.1 - 5.2e-44 150.1 0.0 2e-43 148.2 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDK89499.1 - 2.4e-24 85.8 5.8 3.7e-16 59.5 0.0 4.2 5 0 0 5 5 5 2 Helicase conserved C-terminal domain ResIII PF04851.15 VDK89499.1 - 1.4e-05 25.2 0.0 3.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit His_Phos_1 PF00300.22 VDK89500.1 - 2.6e-17 63.1 0.0 1.5e-09 37.8 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Thiolase_N PF00108.23 VDK89511.1 - 1.9e-80 270.0 0.1 3.3e-80 269.2 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 VDK89511.1 - 3.3e-41 139.8 0.8 6.6e-40 135.6 0.9 2.3 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 VDK89511.1 - 1e-11 44.9 2.7 2.3e-07 30.6 1.6 2.8 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 VDK89511.1 - 7.4e-05 22.5 0.9 0.0023 17.7 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III FAE1_CUT1_RppA PF08392.12 VDK89511.1 - 0.012 15.0 0.2 0.016 14.5 0.2 1.4 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein SpoVAD PF07451.11 VDK89511.1 - 0.026 13.2 0.4 0.048 12.3 0.4 1.4 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) APO_RNA-bind PF05634.11 VDK89511.1 - 0.16 11.3 0.0 0.39 10.1 0.0 1.7 2 0 0 2 2 2 0 APO RNA-binding Copine PF07002.16 VDK89512.1 - 1.2e-24 87.0 0.1 1.9e-24 86.4 0.1 1.3 1 0 0 1 1 1 1 Copine PLA2_B PF01735.18 VDK89512.1 - 0.043 12.2 0.2 0.077 11.4 0.0 1.5 2 0 0 2 2 2 0 Lysophospholipase catalytic domain DUF3439 PF11921.8 VDK89516.1 - 6.5 6.7 11.8 6.2 6.8 11.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF2985 PF11204.8 VDK89517.1 - 5.8 7.1 7.9 2.4 8.4 5.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2985) SET PF00856.28 VDK89525.1 - 2.7e-05 24.6 0.1 4.2e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 SET domain Guanylate_cyc PF00211.20 VDK89526.1 - 6.7e-12 45.4 0.0 1.4e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Helicase_C PF00271.31 VDK89532.1 - 1.5e-14 54.3 0.1 3.9e-14 52.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 VDK89532.1 - 1.6e-10 41.2 0.0 4.6e-10 39.7 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 VDK89532.1 - 2.3e-10 40.7 0.0 7.7e-10 39.0 0.0 2.0 1 1 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 VDK89532.1 - 2.8e-07 30.5 0.0 7.5e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 VDK89532.1 - 1.4e-05 25.4 1.9 4.3e-05 23.8 0.2 2.6 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 VDK89532.1 - 0.00021 21.6 0.0 0.00048 20.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 VDK89532.1 - 0.0053 16.7 0.2 0.021 14.7 0.1 2.1 2 1 0 2 2 2 1 Rad17 P-loop domain T2SSE PF00437.20 VDK89532.1 - 0.085 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 VDK89532.1 - 0.09 12.8 0.0 0.45 10.5 0.0 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 VDK89532.1 - 0.12 12.8 1.4 0.35 11.2 0.1 2.5 3 0 0 3 3 3 0 AAA ATPase domain AAA_29 PF13555.6 VDK89532.1 - 0.2 11.4 0.0 0.54 10.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain CENP-Q PF13094.6 VDK89532.1 - 2.9 8.1 5.6 5 7.3 0.5 2.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit ETX_MTX2 PF03318.13 VDK89533.1 - 3.8e-08 33.4 2.4 5.2e-08 32.9 2.4 1.1 1 0 0 1 1 1 1 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Sulfotransfer_1 PF00685.27 VDK89538.1 - 0.0016 18.0 0.0 0.0016 18.0 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain DUF4350 PF14258.6 VDK89539.1 - 0.17 12.3 0.0 0.36 11.3 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) Ldl_recept_b PF00058.17 VDK89540.1 - 1.1e-21 77.0 7.1 2.2e-05 24.8 0.0 7.0 7 0 0 7 7 7 4 Low-density lipoprotein receptor repeat class B Ldl_recept_a PF00057.18 VDK89540.1 - 7.1e-18 64.5 30.8 2.4e-08 34.0 11.1 4.0 2 1 1 3 3 3 3 Low-density lipoprotein receptor domain class A FXa_inhibition PF14670.6 VDK89540.1 - 5.9e-10 39.3 45.3 2.6e-09 37.2 8.0 4.7 4 0 0 4 4 4 3 Coagulation Factor Xa inhibitory site SGL PF08450.12 VDK89540.1 - 1.2e-05 25.0 0.4 0.0023 17.6 0.0 3.7 3 1 1 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region CBM32 PF18344.1 VDK89540.1 - 0.00069 19.4 0.0 0.039 13.8 0.1 2.9 3 0 0 3 3 3 1 Carbohydrate binding module family 32 TTc_toxin_rep PF18807.1 VDK89540.1 - 0.1 12.5 0.2 0.76 9.6 0.1 2.4 2 0 0 2 2 2 0 Tripartite Tc toxins repeat Pup PF05639.11 VDK89543.1 - 0.0011 19.8 0.1 0.0027 18.6 0.1 1.6 1 0 0 1 1 1 1 Pup-like protein Apolipoprotein PF01442.18 VDK89543.1 - 0.092 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain ANAPC10 PF03256.16 VDK89544.1 - 1.5e-56 190.9 0.1 1.9e-56 190.6 0.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 VDK89544.1 - 0.0029 17.7 0.1 0.0066 16.6 0.1 1.6 1 0 0 1 1 1 1 F5/8 type C domain TBPIP PF07106.13 VDK89545.1 - 3.1e-15 55.9 0.1 8.3e-15 54.5 0.1 1.7 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 VDK89545.1 - 0.014 15.5 3.9 0.021 14.9 2.5 2.1 2 0 0 2 2 2 0 Leucine zipper with capping helix domain GUCT PF08152.12 VDK89545.1 - 0.1 12.9 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 GUCT (NUC152) domain 3HCDH_N PF02737.18 VDK89545.1 - 0.42 10.5 3.1 0.2 11.5 0.3 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YgaB PF14182.6 VDK89545.1 - 0.7 10.3 10.2 3.6 8.0 1.7 2.6 2 0 0 2 2 2 0 YgaB-like protein GCR1_C PF12550.8 VDK89545.1 - 1.1 9.6 4.9 1.7 9.1 2.8 2.4 2 1 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Cation_efflux PF01545.21 VDK89546.1 - 1.2e-53 181.8 9.8 1.5e-53 181.5 9.8 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 VDK89546.1 - 0.05 13.7 1.8 0.058 13.5 0.2 1.9 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter DUF3989 PF13150.6 VDK89546.1 - 0.18 11.6 1.3 0.43 10.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) DUF4668 PF15701.5 VDK89546.1 - 0.27 11.1 4.5 2.8 7.8 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4668) C1_1 PF00130.22 VDK89549.1 - 1.4e-06 28.1 1.0 5.5e-06 26.2 1.0 2.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RasGEF PF00617.19 VDK89549.1 - 3.1e-06 27.5 0.2 5.6e-05 23.4 0.2 2.6 1 1 0 1 1 1 1 RasGEF domain EF-hand_6 PF13405.6 VDK89549.1 - 1.2e-05 24.9 0.2 3.9e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 VDK89549.1 - 6.5e-05 22.2 0.8 0.00014 21.2 0.0 2.1 3 0 0 3 3 3 1 EF hand EF-hand_1 PF00036.32 VDK89549.1 - 8.8e-05 21.8 0.0 0.00024 20.5 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 VDK89549.1 - 0.00021 21.7 0.0 0.00049 20.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair Dockerin_1 PF00404.18 VDK89549.1 - 0.00049 20.2 0.0 0.00096 19.3 0.0 1.5 1 0 0 1 1 1 1 Dockerin type I domain Clathrin_lg_ch PF01086.17 VDK89550.1 - 2e-12 47.7 0.0 2.4e-12 47.4 0.0 1.0 1 0 0 1 1 1 1 Clathrin light chain PAF-AH_p_II PF03403.13 VDK89561.1 - 1.5e-100 336.3 0.0 2e-100 335.9 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 VDK89561.1 - 5e-12 45.3 0.1 1.4e-10 40.5 0.1 2.1 1 1 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 VDK89561.1 - 3.9e-08 32.7 0.0 0.0061 15.6 0.0 2.3 2 0 0 2 2 2 2 Chlorophyllase DLH PF01738.18 VDK89561.1 - 8.2e-07 28.8 0.0 5.3e-06 26.1 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 VDK89561.1 - 1.4e-05 24.5 0.9 0.00073 18.9 0.0 2.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 VDK89561.1 - 9.9e-05 22.3 0.0 0.0066 16.3 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 VDK89561.1 - 0.0015 18.4 0.1 0.0054 16.6 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 VDK89561.1 - 0.0027 17.7 0.0 0.0058 16.6 0.0 1.5 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 VDK89561.1 - 0.0027 18.3 0.0 0.0052 17.4 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 VDK89561.1 - 0.0028 17.5 0.1 0.0053 16.6 0.1 1.5 1 0 0 1 1 1 1 Lipase (class 3) AXE1 PF05448.12 VDK89561.1 - 0.0051 15.5 0.1 0.028 13.1 0.0 2.0 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 VDK89561.1 - 0.0096 15.4 0.1 0.045 13.2 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 VDK89561.1 - 0.013 15.2 0.5 0.032 13.9 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 VDK89561.1 - 0.093 12.5 0.0 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF2974 PF11187.8 VDK89561.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) ubiquitin PF00240.23 VDK89562.1 - 4.5e-05 23.1 0.0 8.7e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 VDK89562.1 - 0.088 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Cation_ATPase_C PF00689.21 VDK89569.1 - 2.9e-40 137.9 9.9 2.9e-39 134.7 6.4 3.0 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 VDK89569.1 - 1.9e-31 109.0 11.1 5.7e-23 81.4 0.5 3.3 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase PF13246.6 VDK89569.1 - 2.2e-21 75.7 0.0 6e-21 74.3 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 VDK89569.1 - 6.3e-17 61.0 1.4 1.9e-15 56.3 0.0 2.9 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 VDK89569.1 - 1.2e-15 58.4 0.8 6.2e-15 56.1 0.8 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ATP_Ca_trans_C PF12424.8 VDK89569.1 - 6.2e-10 39.4 0.2 2.2e-09 37.6 0.2 2.0 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal Hydrolase_3 PF08282.12 VDK89569.1 - 5.3e-08 32.9 1.0 1.2e-05 25.2 0.7 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase zf-C3Hc3H PF13891.6 VDK89571.1 - 6.9e-17 61.6 26.5 1.1e-09 38.5 4.6 3.1 2 1 0 2 2 2 2 Potential DNA-binding domain DUF4573 PF15140.6 VDK89575.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4573) eIF-5_eIF-2B PF01873.17 VDK89576.1 - 5.5e-25 87.5 0.5 1.3e-24 86.3 0.5 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 VDK89576.1 - 5.9e-20 71.2 0.2 1.4e-19 70.0 0.2 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon eIF-5_eIF-2B PF01873.17 VDK89577.1 - 6.1e-25 87.4 0.5 1.5e-24 86.2 0.5 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 VDK89577.1 - 6.7e-20 71.0 0.2 1.6e-19 69.8 0.2 1.7 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Peptidase_M16 PF00675.20 VDK89579.1 - 4.4e-53 179.3 0.2 5.2e-53 179.0 0.2 1.1 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) DUF725 PF05267.12 VDK89579.1 - 0.033 14.2 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF725) Peptidase_M16_C PF05193.21 VDK89580.1 - 2.7e-31 109.0 0.0 3.6e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16 inactive domain Ion_trans_2 PF07885.16 VDK89581.1 - 0.00013 21.9 5.3 0.00038 20.4 0.4 2.2 2 0 0 2 2 2 1 Ion channel Pox_A30L_A26L PF06086.12 VDK89581.1 - 0.023 14.4 0.8 0.15 11.7 0.2 2.0 1 1 1 2 2 2 0 Orthopoxvirus A26L/A30L protein DUF2572 PF10833.8 VDK89581.1 - 0.032 14.0 0.1 0.049 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) Patched PF02460.18 VDK89584.1 - 8.5e-14 50.6 34.9 4.8e-10 38.2 7.0 2.2 2 0 0 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDK89584.1 - 1.4e-06 28.3 5.1 2.2e-06 27.6 2.3 4.0 4 1 0 4 4 4 2 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 VDK89584.1 - 0.0038 16.2 1.4 0.0038 16.2 1.4 3.4 3 1 0 3 3 3 2 MMPL family zf-C2H2_4 PF13894.6 VDK89585.1 - 0.00092 19.9 14.9 3.5 8.7 2.1 4.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Dof PF02701.15 VDK89585.1 - 0.0013 18.8 0.4 0.0013 18.8 0.4 2.5 3 0 0 3 3 3 1 Dof domain, zinc finger zf-RRPl_C4 PF17026.5 VDK89585.1 - 0.0045 17.1 2.2 0.0061 16.7 0.2 2.2 2 0 0 2 2 2 1 Putative ribonucleoprotein zinc-finger pf C4 type zf_C2H2_ZHX PF18387.1 VDK89585.1 - 0.018 14.7 3.9 0.39 10.4 0.7 2.8 2 1 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF3268 PF11672.8 VDK89585.1 - 0.057 13.7 0.3 0.057 13.7 0.3 1.8 2 0 0 2 2 2 0 zinc-finger-containing domain zf-H2C2_2 PF13465.6 VDK89585.1 - 1.4 9.5 4.5 9.2 6.9 0.3 2.9 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_12 PF18658.1 VDK89585.1 - 3.8 7.1 9.6 3.4 7.3 0.8 2.8 2 1 1 3 3 3 0 Zinc-finger C2H2-type C1_2 PF03107.16 VDK89585.1 - 8.8 6.7 8.1 48 4.4 0.1 3.9 3 1 0 3 3 3 0 C1 domain Plexin_cytopl PF08337.12 VDK89587.1 - 4.1e-212 705.7 6.7 8.1e-212 704.8 6.7 1.5 1 1 0 1 1 1 1 Plexin cytoplasmic RasGAP domain TIG PF01833.24 VDK89587.1 - 1.9e-24 85.6 0.2 7.6e-09 35.5 0.0 4.5 4 0 0 4 4 4 4 IPT/TIG domain K1377 PF15352.6 VDK89588.1 - 0.011 14.1 2.3 0.014 13.7 2.3 1.0 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy Laminin_N PF00055.17 VDK89595.1 - 1.3e-83 280.2 0.0 1.3e-83 280.2 0.0 2.4 3 0 0 3 3 3 1 Laminin N-terminal (Domain VI) Laminin_EGF PF00053.24 VDK89595.1 - 2.7e-59 197.1 177.0 4.8e-11 42.6 12.0 10.3 11 0 0 11 11 11 9 Laminin EGF domain Laminin_B PF00052.18 VDK89595.1 - 1.5e-23 83.2 0.0 2.2e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Laminin B (Domain IV) Y_phosphatase PF00102.27 VDK89598.1 - 1.4e-40 139.3 2.0 7e-20 71.6 0.1 2.2 1 1 1 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 VDK89598.1 - 0.002 18.0 0.0 0.0057 16.5 0.0 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 VDK89598.1 - 0.0069 16.5 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 VDK89598.1 - 0.01 15.8 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Myotub-related PF06602.14 VDK89598.1 - 0.013 14.4 0.3 0.02 13.8 0.3 1.4 1 1 0 1 1 1 0 Myotubularin-like phosphatase domain Pkinase_Tyr PF07714.17 VDK89600.1 - 2.4e-43 148.3 0.0 2.8e-43 148.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDK89600.1 - 3.2e-41 141.4 0.0 4e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 VDK89600.1 - 4.7e-07 29.4 0.0 6.1e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDK89600.1 - 7.6e-05 21.6 0.0 0.00011 21.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 VDK89600.1 - 0.0012 18.2 0.1 0.0029 17.0 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDK89600.1 - 0.0013 18.7 0.0 0.005 16.8 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 VDK89600.1 - 0.16 11.6 0.0 0.41 10.2 0.0 1.6 2 0 0 2 2 2 0 RIO1 family PI-PLC-X PF00388.19 VDK89606.1 - 1.2e-46 157.9 0.0 1.9e-46 157.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 VDK89606.1 - 5.1e-26 91.3 0.0 3.3e-25 88.7 0.0 2.4 3 0 0 3 3 3 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 VDK89606.1 - 1e-19 70.7 0.0 2.5e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain EF-hand_like PF09279.11 VDK89606.1 - 6.4e-09 36.2 0.0 1.6e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_10 PF14788.6 VDK89606.1 - 6.8e-09 35.4 1.0 1.8e-08 34.1 1.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 VDK89606.1 - 1.6e-07 30.4 0.8 0.00067 19.0 0.1 3.4 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 VDK89606.1 - 2e-05 23.8 2.2 0.00074 18.9 0.2 3.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 VDK89606.1 - 2.2e-05 24.0 1.9 0.016 15.1 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain GDPD PF03009.17 VDK89606.1 - 0.0004 20.2 0.0 0.00072 19.4 0.0 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family EF-hand_8 PF13833.6 VDK89606.1 - 0.00073 19.3 0.3 0.13 12.1 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 VDK89606.1 - 0.004 17.6 4.5 0.0097 16.3 1.9 3.1 2 1 0 2 2 2 1 EF-hand domain pair Myb_DNA-binding PF00249.31 VDK89607.1 - 5.8e-12 45.6 2.5 1.1e-06 28.7 0.3 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain RAC_head PF16717.5 VDK89607.1 - 4.2e-09 37.3 1.7 4.2e-09 37.3 1.7 4.0 3 2 1 4 4 4 1 Ribosome-associated complex head domain Helicase_Sgs1 PF11408.8 VDK89607.1 - 0.001 19.1 0.5 0.0027 17.7 0.4 1.9 1 1 0 1 1 1 1 Sgs1 RecQ helicase SAE2 PF08573.10 VDK89607.1 - 0.0082 17.3 6.7 0.0082 17.3 6.7 2.9 2 1 0 2 2 2 1 DNA repair protein endonuclease SAE2/CtIP C-terminus Aconitase_C PF00694.19 VDK89607.1 - 0.42 11.0 0.1 0.42 11.0 0.1 2.9 2 1 1 3 3 3 0 Aconitase C-terminal domain DUP PF00674.18 VDK89607.1 - 0.52 10.5 5.1 4.6 7.4 0.1 3.6 2 2 2 4 4 4 0 DUP family LodA_N PF17990.1 VDK89607.1 - 1.9 8.4 13.7 0.63 9.9 5.4 2.4 2 1 0 2 2 2 0 L-Lysine epsilon oxidase N-terminal Cofilin_ADF PF00241.20 VDK89608.1 - 4.8e-27 94.2 1.2 1.1e-17 63.9 0.2 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein CLPTM1 PF05602.12 VDK89609.1 - 0.065 12.2 5.9 0.13 11.2 5.9 1.5 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) ALMT PF11744.8 VDK89609.1 - 3.4 6.4 6.2 5.4 5.7 6.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter SDP_N PF12278.8 VDK89612.1 - 0.012 15.7 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 0 Sex determination protein N terminal Nicastrin PF05450.15 VDK89614.1 - 1.2e-35 123.1 0.1 1.9e-35 122.5 0.1 1.2 1 0 0 1 1 1 1 Nicastrin Ncstrn_small PF18266.1 VDK89614.1 - 8.7e-31 107.2 0.0 6.9e-29 101.0 0.0 2.3 1 1 0 1 1 1 1 Nicastrin small lobe Peptidase_M28 PF04389.17 VDK89614.1 - 0.0014 18.4 0.1 0.003 17.3 0.1 1.6 1 1 0 1 1 1 1 Peptidase family M28 Orai-1 PF07856.12 VDK89623.1 - 5.5e-33 114.1 9.5 7.8e-33 113.6 9.5 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity CD24 PF14984.6 VDK89623.1 - 0.029 14.6 0.2 0.029 14.6 0.2 1.6 2 0 0 2 2 2 0 CD24 protein Orai-1 PF07856.12 VDK89624.1 - 1.9e-07 30.9 0.2 2.8e-07 30.4 0.2 1.2 1 0 0 1 1 1 1 Mediator of CRAC channel activity TraK PF06586.11 VDK89624.1 - 0.085 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 TraK protein Neur_chan_LBD PF02931.23 VDK89627.1 - 5.4e-32 111.0 1.5 6e-32 110.8 1.5 1.0 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDK89628.1 - 4.6e-61 206.9 12.6 2.4e-59 201.3 12.6 2.0 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 VDK89628.1 - 6.8e-35 120.5 0.0 9.9e-35 119.9 0.0 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain DUF2561 PF10812.8 VDK89628.1 - 0.18 11.8 0.0 1.7 8.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2561) Claudin_2 PF13903.6 VDK89628.1 - 0.23 11.2 2.0 0.45 10.3 2.0 1.5 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Chorion_3 PF05387.11 VDK89631.1 - 4.2 6.9 6.1 4.8 6.7 6.1 1.1 1 0 0 1 1 1 0 Chorion family 3 YfhO PF09586.10 VDK89636.1 - 1.2 7.2 5.3 1.8 6.7 5.3 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Exo_endo_phos PF03372.23 VDK89637.1 - 3.5e-11 43.1 0.2 9.4e-11 41.7 0.2 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2046 PF09755.9 VDK89642.1 - 0.01 15.1 3.5 0.01 15.1 3.5 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) zf-ribbon_3 PF13248.6 VDK89642.1 - 0.027 13.9 0.9 0.078 12.4 0.9 1.8 1 0 0 1 1 1 0 zinc-ribbon domain OmpH PF03938.14 VDK89642.1 - 0.76 10.1 4.3 1.4 9.2 4.3 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Bcr-Abl_Oligo PF09036.10 VDK89642.1 - 0.98 9.5 8.8 2.5 8.2 1.4 3.4 2 1 2 4 4 4 0 Bcr-Abl oncoprotein oligomerisation domain SlyX PF04102.12 VDK89642.1 - 6.8 7.4 8.8 5.7 7.6 1.3 3.2 2 1 1 3 3 3 0 SlyX SCHIP-1 PF10148.9 VDK89643.1 - 0.028 14.1 5.9 0.7 9.5 0.5 2.6 3 0 0 3 3 3 0 Schwannomin-interacting protein 1 FemAB PF02388.16 VDK89643.1 - 4.1 6.2 5.9 7.1 5.4 5.9 1.3 1 0 0 1 1 1 0 FemAB family Ras PF00071.22 VDK89651.1 - 4.1e-55 185.8 0.2 1.9e-54 183.6 0.2 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 VDK89651.1 - 8.7e-28 97.0 0.1 4.1e-27 94.8 0.1 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDK89651.1 - 1.4e-09 37.7 0.0 6.4e-09 35.5 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDK89651.1 - 0.00015 21.4 0.0 0.0011 18.5 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDK89651.1 - 0.00045 20.3 0.0 0.00093 19.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDK89651.1 - 0.0015 18.5 0.0 1.7 8.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Septin PF00735.18 VDK89651.1 - 0.0048 16.2 0.0 0.0072 15.6 0.0 1.2 1 0 0 1 1 1 1 Septin AAA_24 PF13479.6 VDK89651.1 - 0.054 13.2 0.1 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 VDK89651.1 - 0.088 12.0 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Gtr1_RagA PF04670.12 VDK89651.1 - 0.096 12.0 0.0 0.17 11.2 0.0 1.5 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 VDK89651.1 - 0.17 12.3 0.0 0.29 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain SURF4 PF02077.15 VDK89652.1 - 3.8e-97 325.1 12.9 3.2e-79 266.3 7.4 2.1 1 1 1 2 2 2 2 SURF4 family SURF2 PF05477.11 VDK89652.1 - 4.7e-05 23.2 0.0 0.082 12.6 0.0 2.3 2 0 0 2 2 2 2 Surfeit locus protein 2 (SURF2) Gal-bind_lectin PF00337.22 VDK89653.1 - 6.8e-16 58.0 0.0 7.3e-16 57.9 0.0 1.0 1 0 0 1 1 1 1 Galactoside-binding lectin Innexin PF00876.18 VDK89656.1 - 2.8e-126 421.5 16.3 3.3e-126 421.3 16.3 1.0 1 0 0 1 1 1 1 Innexin Catalase-rel PF06628.12 VDK89656.1 - 0.14 12.4 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 Catalase-related immune-responsive CH PF00307.31 VDK89658.1 - 1.7e-22 79.6 0.0 3.9e-22 78.5 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDK89658.1 - 1.7e-07 30.9 0.0 3.6e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 CAMSAP CH domain HSBP1 PF06825.12 VDK89658.1 - 0.025 14.4 0.3 0.34 10.8 0.1 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Kelch_3 PF13415.6 VDK89662.1 - 1.8e-38 130.1 4.9 1.7e-08 34.5 0.0 7.2 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 VDK89662.1 - 3.3e-38 129.0 8.2 3.2e-08 33.0 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 VDK89662.1 - 9e-38 127.7 10.6 5e-06 26.4 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 VDK89662.1 - 1.6e-37 126.6 1.2 1.3e-06 28.5 0.0 6.3 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 VDK89662.1 - 2.1e-34 116.2 10.9 7.7e-06 25.7 0.0 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 VDK89662.1 - 3.6e-33 113.3 2.7 6.8e-06 26.0 0.0 6.9 5 1 1 6 6 6 6 Galactose oxidase, central domain LRR_4 PF12799.7 VDK89669.1 - 1.1e-36 124.2 40.8 1.6e-09 37.9 0.3 7.4 3 2 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDK89669.1 - 3.2e-21 75.6 15.0 4.8e-08 32.7 0.4 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_8 PF13855.6 VDK89669.1 - 4.4e-18 64.8 28.5 7.9e-08 32.0 2.3 6.3 2 2 5 7 7 7 7 Leucine rich repeat LRR_6 PF13516.6 VDK89669.1 - 2.8e-07 30.1 6.0 1.7 8.9 0.1 6.9 5 1 1 6 6 6 2 Leucine Rich repeat DUF4538 PF15061.6 VDK89669.1 - 0.0064 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4538) LRR_1 PF00560.33 VDK89669.1 - 0.025 15.1 22.6 4.3 8.3 0.1 9.1 9 2 0 9 9 9 0 Leucine Rich Repeat DUF3911 PF13050.6 VDK89669.1 - 0.091 12.9 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3911) Peptidase_M28 PF04389.17 VDK89670.1 - 4.1e-25 88.6 0.0 6.9e-25 87.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 VDK89670.1 - 3.3e-06 26.9 0.0 6.5e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PA PF02225.22 VDK89670.1 - 0.0011 18.9 0.1 0.0024 17.9 0.1 1.5 1 0 0 1 1 1 1 PA domain HEAT PF02985.22 VDK89675.1 - 6.2e-13 47.8 0.0 0.12 12.7 0.0 5.9 5 0 0 5 5 5 4 HEAT repeat HEAT_2 PF13646.6 VDK89675.1 - 4e-08 33.5 0.0 0.0018 18.6 0.0 3.3 1 1 2 3 3 3 2 HEAT repeats Cnd1 PF12717.7 VDK89675.1 - 6.2e-08 32.9 0.0 0.0048 17.0 0.0 2.6 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 VDK89675.1 - 7.8e-06 26.3 3.3 1.4 9.5 0.0 4.6 4 1 1 5 5 5 2 HEAT-like repeat Pkinase PF00069.25 VDK89675.1 - 0.0019 17.6 0.0 0.004 16.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Cohesin_HEAT PF12765.7 VDK89675.1 - 0.022 15.1 0.0 0.067 13.5 0.0 1.9 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion Adaptin_N PF01602.20 VDK89675.1 - 0.024 13.2 0.1 0.2 10.2 0.1 2.1 1 1 0 1 1 1 0 Adaptin N terminal region DUF4047 PF13256.6 VDK89675.1 - 0.73 10.0 3.9 0.16 12.2 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) PDZ PF00595.24 VDK89676.1 - 7e-14 52.0 3.5 1.9e-06 28.1 0.8 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDK89676.1 - 8.7e-12 45.2 2.8 4.9e-06 26.8 0.4 2.3 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK89676.1 - 1.1e-08 34.8 0.3 4.8e-05 23.1 0.0 2.5 2 0 0 2 2 2 2 PDZ domain PDZ_4 PF17816.1 VDK89676.1 - 2.9e-05 24.4 0.5 0.016 15.6 0.0 2.4 2 1 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 VDK89676.1 - 0.00097 19.1 1.4 0.93 9.5 0.1 2.5 2 1 0 2 2 2 2 Tricorn protease PDZ domain DUF4946 PF16304.5 VDK89682.1 - 0.14 11.8 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4946) PRIMA1 PF16101.5 VDK89682.1 - 0.62 10.1 6.0 0.86 9.6 6.0 1.5 1 1 0 1 1 1 0 Proline-rich membrane anchor 1 PDZ PF00595.24 VDK89684.1 - 1e-12 48.2 0.4 6.7e-09 36.0 0.2 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDK89684.1 - 2.7e-07 30.3 0.1 1.2e-05 25.0 0.1 2.5 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 VDK89684.1 - 0.0025 18.1 0.1 1.6 9.1 0.0 3.3 3 0 0 3 3 3 1 PDZ domain Med3 PF11593.8 VDK89684.1 - 0.016 14.4 4.1 0.021 14.1 4.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Csm1_N PF18504.1 VDK89686.1 - 0.0013 19.0 5.4 0.0017 18.7 4.1 1.9 1 1 1 2 2 2 1 Csm1 N-terminal domain TBCA PF02970.16 VDK89686.1 - 0.022 15.1 2.4 0.025 14.9 0.8 1.8 1 1 0 2 2 2 0 Tubulin binding cofactor A Com_YlbF PF06133.11 VDK89686.1 - 0.03 14.9 3.5 0.048 14.3 3.5 1.3 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA FAM76 PF16046.5 VDK89686.1 - 0.15 11.4 1.3 0.17 11.2 1.3 1.1 1 0 0 1 1 1 0 FAM76 protein Zona_pellucida PF00100.23 VDK89689.1 - 9.7e-08 32.1 3.7 1.4e-07 31.6 3.7 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain LRV_FeS PF05484.11 VDK89690.1 - 0.19 11.7 0.4 0.27 11.3 0.4 1.2 1 0 0 1 1 1 0 LRV protein FeS4 cluster LRR_8 PF13855.6 VDK89691.1 - 1.6e-21 75.8 36.4 3.6e-05 23.4 0.2 6.5 5 2 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 VDK89691.1 - 3.3e-16 59.1 44.3 8.2e-07 29.3 0.5 6.8 7 0 0 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDK89691.1 - 0.0025 17.4 6.2 0.0025 17.4 6.2 3.1 1 1 2 3 3 3 2 Leucine-rich repeat Shikimate_DH PF01488.20 VDK89691.1 - 0.031 14.3 0.1 0.085 12.9 0.1 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase LRR_1 PF00560.33 VDK89691.1 - 0.057 14.0 39.0 0.37 11.5 0.2 9.9 9 2 0 9 9 9 0 Leucine Rich Repeat HigB_toxin PF09907.9 VDK89691.1 - 0.32 11.2 1.6 2.8 8.2 0.1 2.9 2 1 1 3 3 3 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system LRR_6 PF13516.6 VDK89691.1 - 2.4 8.4 21.8 4.3 7.6 0.1 7.4 8 0 0 8 8 8 0 Leucine Rich repeat Dehydrin PF00257.19 VDK89695.1 - 1.7 9.2 9.1 0.91 10.1 2.8 2.8 2 0 0 2 2 2 0 Dehydrin SRCR PF00530.18 VDK89697.1 - 8e-31 106.5 0.1 3.9e-15 56.2 0.0 2.5 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Beta_helix PF13229.6 VDK89697.1 - 1.6e-10 41.1 29.8 0.00051 19.9 0.3 4.1 2 1 1 3 3 3 3 Right handed beta helix region SRCR_2 PF15494.6 VDK89697.1 - 4.8e-09 36.6 2.2 4.5e-05 23.9 0.2 2.6 2 0 0 2 2 2 2 Scavenger receptor cysteine-rich domain Hepsin-SRCR PF09272.10 VDK89697.1 - 6.4e-05 23.4 0.3 0.18 12.3 0.0 2.6 2 0 0 2 2 2 2 Hepsin, SRCR domain DUF1565 PF07602.11 VDK89697.1 - 4.9 6.4 20.0 3.4 7.0 2.1 4.4 4 1 1 5 5 5 0 Protein of unknown function (DUF1565) Globin PF00042.22 VDK89701.1 - 9.1e-07 29.4 0.0 1.8e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Globin Ig_3 PF13927.6 VDK89706.1 - 1.4e-17 64.1 3.0 8.1e-07 29.6 0.1 3.7 4 0 0 4 4 4 3 Immunoglobulin domain I-set PF07679.16 VDK89706.1 - 2.2e-13 50.1 0.4 1e-05 25.5 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin I-set domain Ig_2 PF13895.6 VDK89706.1 - 1.2e-12 47.9 3.0 8.5e-05 22.8 0.1 3.6 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 VDK89706.1 - 5.5e-09 36.1 2.3 0.00044 20.4 0.2 4.0 4 0 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 VDK89706.1 - 8.7e-07 29.1 0.2 0.0017 18.5 0.0 2.9 2 0 0 2 2 2 2 Immunoglobulin V-set domain fn3 PF00041.21 VDK89706.1 - 0.00025 21.4 0.0 0.0015 18.8 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain Ig_6 PF18452.1 VDK89706.1 - 0.0019 17.8 0.0 0.06 12.9 0.0 2.8 2 0 0 2 2 2 1 Immunoglobulin domain Izumo-Ig PF16706.5 VDK89706.1 - 0.0021 18.1 0.1 4.3 7.5 0.0 2.7 2 0 0 2 2 2 2 Izumo-like Immunoglobulin domain C2-set PF05790.15 VDK89706.1 - 0.012 15.8 0.1 5.2 7.3 0.0 2.6 2 0 0 2 2 2 0 Immunoglobulin C2-set domain CarboxypepD_reg PF13620.6 VDK89706.1 - 0.13 12.5 0.1 0.55 10.5 0.0 2.1 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain SUR7 PF06687.12 VDM91306.1 - 0.0099 15.5 0.9 0.011 15.3 0.9 1.2 1 0 0 1 1 1 1 SUR7/PalI family TssO PF17561.2 VDM91306.1 - 0.043 13.9 0.3 0.076 13.1 0.1 1.5 2 0 0 2 2 2 0 Type VI secretion system, TssO TMEM219 PF14940.6 VDM91306.1 - 0.061 12.9 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Transmembrane 219 PWWP PF00855.17 VDM91307.1 - 0.00094 19.5 13.6 0.012 16.0 0.8 4.4 3 3 0 3 3 3 2 PWWP domain RTC4 PF14474.6 VDM91307.1 - 0.014 15.6 0.0 2.8 8.1 0.1 2.9 2 0 0 2 2 2 0 RTC4-like domain Ntox15 PF15604.6 VDM91307.1 - 0.42 10.7 0.0 0.42 10.7 0.0 2.6 2 1 1 3 3 3 0 Novel toxin 15 Mito_carr PF00153.27 VDM91308.1 - 9.1e-24 83.2 1.2 1.6e-16 60.0 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein FSA_C PF10479.9 VDM91309.1 - 6.6e-13 47.7 2.1 3.9e-10 38.6 0.1 2.0 1 1 1 2 2 2 2 Fragile site-associated protein C-terminus Plectin PF00681.20 VDM91309.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Plectin repeat T4SS_TraI PF16932.5 VDM91309.1 - 0.18 11.0 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Type IV secretory system, conjugal DNA-protein transfer LisH PF08513.11 VDM91310.1 - 0.0066 16.4 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 LisH TauE PF01925.19 VDM91311.1 - 1.1e-19 71.0 16.0 1.1e-19 71.0 16.0 1.7 1 1 1 2 2 2 1 Sulfite exporter TauE/SafE Voltage_CLC PF00654.20 VDM91311.1 - 0.0045 16.3 15.6 0.0082 15.4 15.6 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel DUF2897 PF11446.8 VDM91311.1 - 0.092 12.7 0.1 0.25 11.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) Phage_holin_2_1 PF04971.12 VDM91311.1 - 1.9 8.5 5.9 6.2 6.9 0.0 3.6 3 0 0 3 3 3 0 Bacteriophage P21 holin S DUF4191 PF13829.6 VDM91311.1 - 7.1 5.9 10.3 7 5.9 0.3 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4191) Ndr PF03096.14 VDM91312.1 - 9.8e-92 306.6 0.2 1.1e-91 306.4 0.2 1.0 1 0 0 1 1 1 1 Ndr family ACP_syn_III PF08545.10 VDM91312.1 - 0.034 14.0 0.0 0.092 12.6 0.0 1.8 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GDA1_CD39 PF01150.17 VDM91313.1 - 3.1e-132 441.2 0.0 3.8e-132 440.9 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family KTI12 PF08433.10 VDM91314.1 - 1e-76 258.0 0.0 2.1e-76 257.0 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 VDM91314.1 - 9.7e-08 32.3 0.0 2.7e-06 27.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 VDM91314.1 - 2.2e-05 25.0 0.1 0.00015 22.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 VDM91314.1 - 0.088 12.9 0.0 0.18 11.9 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 VDM91314.1 - 0.092 13.3 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 VDM91314.1 - 0.094 13.0 0.1 0.18 12.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain Clat_adaptor_s PF01217.20 VDM91315.1 - 1e-60 203.8 7.8 1.1e-60 203.7 7.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4649 PF15507.6 VDM91315.1 - 0.011 15.7 1.0 0.015 15.2 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4649) Acetyltransf_10 PF13673.7 VDM91316.1 - 0.002 18.1 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 VDM91316.1 - 0.0048 16.8 0.0 0.016 15.2 0.0 1.8 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.7 VDM91316.1 - 0.028 14.9 0.0 0.054 13.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Autoind_bind PF03472.15 VDM91316.1 - 0.043 13.3 0.0 0.067 12.7 0.0 1.3 1 0 0 1 1 1 0 Autoinducer binding domain Acetyltransf_9 PF13527.7 VDM91316.1 - 0.076 13.1 0.0 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF3138 PF11336.8 VDM91321.1 - 0.13 10.9 4.0 0.11 11.2 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) Fusion_gly PF00523.18 VDM91321.1 - 0.74 8.0 3.7 0.88 7.7 3.7 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 Med3 PF11593.8 VDM91321.1 - 2.5 7.2 6.4 2.5 7.2 6.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RRM_5 PF13893.6 VDM91324.1 - 1.3e-37 128.1 1.1 1.2e-25 89.5 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 VDM91324.1 - 1.2e-18 66.7 0.3 4.6e-06 26.3 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 VDM91324.1 - 7e-15 55.0 0.1 1.8e-14 53.7 0.1 1.7 1 0 0 1 1 1 1 RRM-like domain RRM_occluded PF16842.5 VDM91324.1 - 0.0011 18.8 0.1 0.22 11.4 0.0 2.9 3 0 0 3 3 3 1 Occluded RNA-recognition motif Macoilin PF09726.9 VDM91324.1 - 3.3 6.2 16.3 5.5 5.4 16.3 1.4 1 0 0 1 1 1 0 Macoilin family Glyco_transf_7N PF13733.6 VDM91326.1 - 1.1e-41 141.5 0.2 2.7e-41 140.4 0.0 1.7 2 0 0 2 2 2 1 N-terminal region of glycosyl transferase group 7 Glyco_transf_7C PF02709.14 VDM91326.1 - 4.2e-28 96.8 0.7 8.8e-28 95.8 0.4 1.7 2 0 0 2 2 2 1 N-terminal domain of galactosyltransferase Tetraspanin PF00335.20 VDM91329.1 - 1.7e-20 73.8 14.6 1.7e-20 73.8 14.6 1.3 1 1 0 1 1 1 1 Tetraspanin family SUR7 PF06687.12 VDM91329.1 - 0.036 13.7 5.3 0.043 13.4 1.0 2.1 2 0 0 2 2 2 0 SUR7/PalI family Oxidored_q3 PF00499.20 VDM91329.1 - 2.4 7.9 15.2 0.24 11.1 8.4 2.1 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF1700 PF08006.11 VDM91329.1 - 8 6.0 12.1 0.83 9.2 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) CoA_binding_3 PF13727.6 VDM91329.1 - 9.5 6.2 11.1 0.051 13.6 1.3 1.9 2 0 0 2 2 2 0 CoA-binding domain Phasin_2 PF09361.10 VDM91330.1 - 0.083 13.2 0.7 0.22 11.8 0.1 1.8 2 0 0 2 2 2 0 Phasin protein TBD PF12845.7 VDM91330.1 - 0.2 11.6 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 TBD domain BAR PF03114.18 VDM91332.1 - 1.6e-09 37.8 3.1 2.4e-09 37.2 3.1 1.2 1 0 0 1 1 1 1 BAR domain SATase_N PF06426.14 VDM91332.1 - 0.098 13.0 0.0 0.31 11.4 0.0 1.7 2 0 0 2 2 2 0 Serine acetyltransferase, N-terminal HSCB_C PF07743.13 VDM91332.1 - 0.11 13.0 5.5 0.27 11.7 0.3 3.1 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Hrs_helical PF12210.8 VDM91332.1 - 4.1 8.0 6.7 5.8 7.5 0.0 3.1 4 0 0 4 4 4 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Homeodomain PF00046.29 VDM91337.1 - 1.3e-20 73.0 3.8 1.9e-20 72.4 3.8 1.2 1 0 0 1 1 1 1 Homeodomain Herpes_capsid PF06112.11 VDM91337.1 - 0.0054 16.8 1.8 0.0075 16.4 1.8 1.2 1 0 0 1 1 1 1 Gammaherpesvirus capsid protein Homeobox_KN PF05920.11 VDM91337.1 - 0.24 11.4 2.1 0.61 10.0 2.1 1.7 1 0 0 1 1 1 0 Homeobox KN domain SR-25 PF10500.9 VDM91337.1 - 1.8 8.1 12.6 0.43 10.1 9.1 1.7 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Meis_PKNOX_N PF16493.5 VDM91339.1 - 0.012 16.0 0.1 0.018 15.4 0.1 1.3 1 0 0 1 1 1 0 N-terminal of Homeobox Meis and PKNOX1 DUF3446 PF11928.8 VDM91339.1 - 0.04 14.2 0.1 0.04 14.2 0.1 1.9 2 1 0 2 2 2 0 Early growth response N-terminal domain zf-C4 PF00105.18 VDM91342.1 - 2.1e-06 28.1 1.2 3.4e-06 27.4 1.2 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Trypsin PF00089.26 VDM91344.1 - 8.2e-16 58.5 0.1 2.7e-11 43.7 0.0 3.0 1 1 1 2 2 2 2 Trypsin DUF316 PF03761.15 VDM91344.1 - 2.2e-09 37.3 0.0 0.00053 19.6 0.0 2.9 3 1 0 3 3 3 2 Chymotrypsin family Peptidase-S1 TcpF PF06340.11 VDM91345.1 - 0.056 12.3 0.0 0.071 12.0 0.0 1.1 1 0 0 1 1 1 0 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F 7tm_1 PF00001.21 VDM91349.1 - 1.5e-44 152.3 0.3 1.9e-44 152.0 0.4 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDM91349.1 - 2.2e-08 33.8 4.1 3.9e-08 33.0 4.1 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 VDM91349.1 - 4.7e-07 29.7 6.2 7.4e-07 29.1 6.2 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srw PF10324.9 VDM91349.1 - 4e-05 23.1 4.7 0.00012 21.5 4.7 1.7 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw 7TM_GPCR_Srbc PF10316.9 VDM91349.1 - 0.00023 20.8 7.4 0.00048 19.7 7.4 1.6 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srv PF10323.9 VDM91349.1 - 0.0026 17.2 2.1 0.0048 16.3 2.1 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv Ferric_reduct PF01794.19 VDM91349.1 - 0.15 12.2 4.1 0.22 11.6 3.0 1.8 2 0 0 2 2 2 0 Ferric reductase like transmembrane component Transposase_20 PF02371.16 VDM91349.1 - 0.55 10.6 2.5 0.43 10.9 0.6 1.8 2 0 0 2 2 2 0 Transposase IS116/IS110/IS902 family DUF1772 PF08592.11 VDM91349.1 - 1.2 9.4 3.7 3.9 7.8 1.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1772) Nic96 PF04097.14 VDM91351.1 - 6.3e-107 358.6 0.0 8.3e-107 358.2 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 TPR_14 PF13428.6 VDM91351.1 - 0.045 14.6 2.7 80 4.5 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDM91351.1 - 0.09 13.0 0.0 7.4 6.9 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_WDAD PF04053.14 VDM91351.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Coatomer WD associated region Myosin_head PF00063.21 VDM91353.1 - 1.5e-264 879.4 0.1 1.8e-264 879.1 0.1 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 VDM91353.1 - 0.027 14.8 0.0 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 VDM91353.1 - 0.1 12.4 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 VDM91353.1 - 0.1 12.9 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Myosin_tail_1 PF01576.19 VDM91354.1 - 3.5e-130 435.8 248.2 2.1e-129 433.2 248.2 1.8 1 1 0 1 1 1 1 Myosin tail ERM PF00769.19 VDM91354.1 - 0.0006 19.7 31.5 0.0006 19.7 31.5 10.4 2 2 8 10 10 10 2 Ezrin/radixin/moesin family DUF745 PF05335.13 VDM91354.1 - 0.00064 19.5 17.5 0.00064 19.5 17.5 10.2 2 1 13 15 15 15 1 Protein of unknown function (DUF745) Filament PF00038.21 VDM91354.1 - 0.00067 19.3 40.6 0.00067 19.3 40.6 7.5 1 1 3 5 5 5 4 Intermediate filament protein IFT57 PF10498.9 VDM91354.1 - 0.0024 16.9 12.6 0.0024 16.9 12.6 9.4 2 2 7 9 9 9 3 Intra-flagellar transport protein 57 DUF3450 PF11932.8 VDM91354.1 - 0.0028 17.0 4.6 0.0028 17.0 4.6 12.7 2 2 12 14 14 14 4 Protein of unknown function (DUF3450) HIP1_clath_bdg PF16515.5 VDM91354.1 - 0.0083 16.7 3.9 0.0083 16.7 3.9 14.3 2 2 11 15 15 15 4 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1664 PF07889.12 VDM91354.1 - 0.048 13.7 151.1 0.039 14.0 7.0 14.6 2 2 13 16 16 16 0 Protein of unknown function (DUF1664) MscS_porin PF12795.7 VDM91354.1 - 0.31 10.6 212.8 0.043 13.3 30.0 9.4 2 1 6 9 9 9 0 Mechanosensitive ion channel porin domain DUF812 PF05667.11 VDM91354.1 - 9 5.0 217.8 0.4 9.5 27.3 6.6 1 1 4 6 6 6 0 Protein of unknown function (DUF812) LLGL PF08366.13 VDM91356.1 - 9.1e-25 87.0 0.0 1.9e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 LLGL2 ANAPC4_WD40 PF12894.7 VDM91356.1 - 4.8e-10 39.6 1.9 0.2 12.0 0.1 5.1 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 VDM91356.1 - 4.3e-08 33.7 16.8 0.014 16.2 0.2 7.4 7 3 0 7 7 7 3 WD domain, G-beta repeat WD40_like PF17005.5 VDM91356.1 - 0.0083 15.5 0.0 0.056 12.8 0.0 2.3 3 0 0 3 3 3 1 WD40-like domain Hira PF07569.11 VDM91356.1 - 0.027 14.2 0.4 2.8 7.6 0.0 2.9 3 0 0 3 3 3 0 TUP1-like enhancer of split DUF5634_N PF18672.1 VDM91356.1 - 0.068 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5634) Utp8 PF10395.9 VDM91356.1 - 0.082 11.4 0.1 0.43 9.0 0.1 1.9 2 0 0 2 2 2 0 Utp8 family DUF1682 PF07946.14 VDM91364.1 - 0.063 12.5 6.4 0.067 12.4 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Roughex PF06020.11 VDM91364.1 - 0.99 8.4 10.9 0.94 8.5 10.9 1.2 1 0 0 1 1 1 0 Drosophila roughex protein FAM176 PF14851.6 VDM91364.1 - 2.6 7.7 8.2 4 7.1 8.2 1.4 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 VDM91364.1 - 5.6 5.6 11.9 5.8 5.6 11.9 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 VDM91364.1 - 8.8 6.3 7.6 9.9 6.1 7.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Guanylate_cyc PF00211.20 VDM91365.1 - 9e-50 168.8 0.1 1.4e-49 168.2 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 VDM91365.1 - 1.8e-18 66.9 0.3 1.8e-18 66.9 0.3 2.1 1 1 1 2 2 2 2 Adenylyl cyclase N-terminal extracellular and transmembrane region Pex24p PF06398.11 VDM91365.1 - 0.21 10.6 1.2 0.27 10.2 1.2 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2298 PF10060.9 VDM91365.1 - 0.43 9.3 8.7 0.6 8.8 8.7 1.1 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) Vac_Fusion PF02346.16 VDM91368.1 - 0.35 10.5 11.3 0.99 9.1 2.5 4.2 3 1 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 ATG16 PF08614.11 VDM91368.1 - 0.61 10.3 45.1 1.7 8.8 23.6 4.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 VDM91368.1 - 0.86 9.6 53.7 0.094 12.7 2.0 7.0 3 3 4 7 7 7 0 TATA element modulatory factor 1 DNA binding Velvet PF11754.8 VDM91368.1 - 1.2 9.0 9.0 0.18 11.7 1.6 2.2 2 0 0 2 2 2 0 Velvet factor Ubiquitin_4 PF18036.1 VDM91368.1 - 1.6 8.8 7.7 0.28 11.2 0.4 3.5 4 0 0 4 4 4 0 Ubiquitin-like domain ZapB PF06005.12 VDM91368.1 - 2.1 8.9 56.2 0.22 12.0 13.4 7.0 5 1 2 7 7 7 0 Cell division protein ZapB DUF4201 PF13870.6 VDM91368.1 - 2.1 8.0 47.0 0.12 12.1 21.5 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) ubiquitin PF00240.23 VDM91368.1 - 2.4 8.0 8.2 0.83 9.5 0.2 3.6 4 1 0 4 4 4 0 Ubiquitin family DUF1729 PF08354.10 VDM91368.1 - 5.8 5.7 12.4 0.084 11.8 4.1 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1729) SWIM PF04434.17 VDM91369.1 - 0.00081 19.0 7.7 0.00081 19.0 7.7 2.6 3 0 0 3 3 3 1 SWIM zinc finger E1-E2_ATPase PF00122.20 VDM91371.1 - 1.7e-22 79.9 0.0 2.8e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 VDM91371.1 - 0.024 14.9 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase FYVE_2 PF02318.16 VDM91373.1 - 7.2e-12 45.6 10.8 7.2e-12 45.6 10.8 2.1 2 0 0 2 2 2 1 FYVE-type zinc finger DUF1367 PF07105.11 VDM91373.1 - 0.054 13.2 0.7 0.11 12.2 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1367) ComX PF05952.12 VDM91373.1 - 0.11 12.4 0.1 0.3 11.1 0.1 1.7 1 0 0 1 1 1 0 Bacillus competence pheromone ComX zf-piccolo PF05715.13 VDM91373.1 - 3.1 8.0 10.9 8.8 6.6 10.9 1.8 1 1 0 1 1 1 0 Piccolo Zn-finger Taxilin PF09728.9 VDM91373.1 - 6.8 5.8 21.1 0.035 13.3 7.7 2.2 2 0 0 2 2 2 0 Myosin-like coiled-coil protein C1_1 PF00130.22 VDM91373.1 - 9.8 6.1 12.3 2.5 8.1 6.7 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Sugar_tr PF00083.24 VDM91375.1 - 3.2e-30 105.4 15.6 2.2e-29 102.7 15.6 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDM91375.1 - 8.5e-25 87.4 52.7 9.1e-20 70.9 31.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AAA_lid_8 PF17868.1 VDM91375.1 - 0.019 14.9 0.0 0.064 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA lid domain MAAL_C PF07476.11 VDM91376.1 - 0.029 13.5 0.2 0.042 13.0 0.2 1.3 1 1 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus TRADD_N PF09034.10 VDM91376.1 - 0.033 14.2 1.0 0.055 13.5 1.0 1.3 1 0 0 1 1 1 0 TRADD, N-terminal domain Prefoldin_2 PF01920.20 VDM91376.1 - 0.11 12.5 6.5 0.098 12.6 4.6 1.8 1 1 0 1 1 1 0 Prefoldin subunit Zwint PF15556.6 VDM91376.1 - 0.11 12.0 8.4 0.28 10.7 8.4 1.6 1 1 0 1 1 1 0 ZW10 interactor ATP-synt_B PF00430.18 VDM91376.1 - 0.13 12.3 10.2 0.054 13.6 5.8 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) YlqD PF11068.8 VDM91376.1 - 4.3 7.7 10.8 0.33 11.3 2.7 2.0 1 1 1 2 2 2 0 YlqD protein HSCB_C PF07743.13 VDM91376.1 - 7.7 7.1 10.2 17 6.0 2.2 2.8 1 1 2 3 3 3 0 HSCB C-terminal oligomerisation domain PhoD_N PF16655.5 VDM91381.1 - 0.052 14.1 1.4 0.33 11.5 1.4 2.4 1 1 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain AMP-binding PF00501.28 VDM91385.1 - 1.9e-68 231.0 0.0 6.7e-49 166.6 0.0 3.6 2 2 0 2 2 2 2 AMP-binding enzyme FAM176 PF14851.6 VDM91387.1 - 0.068 12.8 6.0 0.084 12.5 6.0 1.3 1 0 0 1 1 1 0 FAM176 family Rhabdo_ncap PF00945.18 VDM91387.1 - 0.68 8.8 5.7 0.67 8.8 5.7 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein TFB6 PF17110.5 VDM91387.1 - 0.71 9.6 7.6 0.75 9.5 7.6 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RNase_H2_suC PF08615.11 VDM91387.1 - 0.71 10.0 3.3 0.84 9.8 3.3 1.2 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Sigma70_ner PF04546.13 VDM91387.1 - 4.7 7.1 15.0 5.3 6.9 15.0 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.9 VDM91387.1 - 9 5.3 30.5 9.5 5.2 30.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF148 PF02520.17 VDM91389.1 - 0.0091 16.1 0.5 0.019 15.1 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF148 Popeye PF04831.13 VDM91389.1 - 0.055 13.7 0.0 0.074 13.2 0.0 1.1 1 0 0 1 1 1 0 Popeye protein conserved region Peptidase_U57 PF05582.12 VDM91389.1 - 0.13 11.5 0.5 0.16 11.2 0.5 1.1 1 0 0 1 1 1 0 YabG peptidase U57 Collagen PF01391.18 VDM91390.1 - 2.8e-24 84.6 99.2 2.2e-10 40.1 31.8 4.1 3 1 0 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDM91390.1 - 1.9e-19 69.5 0.4 2.5e-19 69.1 0.4 1.1 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain Pkinase PF00069.25 VDM91396.1 - 1.3e-65 221.4 0.0 1.7e-65 221.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM91396.1 - 3.7e-32 111.6 0.0 5.2e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 VDM91396.1 - 1.4e-12 47.3 9.4 2.6e-12 46.4 9.4 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PB1 PF00564.24 VDM91396.1 - 5.4e-12 45.5 0.3 2.8e-11 43.2 0.0 2.4 3 0 0 3 3 3 1 PB1 domain Pkinase_C PF00433.24 VDM91396.1 - 4.3e-08 33.7 3.6 9.2e-08 32.7 3.6 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 VDM91396.1 - 4.8e-05 22.8 0.0 0.00011 21.6 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 VDM91396.1 - 0.0023 16.9 0.0 0.0036 16.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 VDM91396.1 - 0.013 15.2 0.2 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 VDM91396.1 - 0.058 13.3 0.0 0.16 11.9 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family C1_2 PF03107.16 VDM91396.1 - 0.54 10.6 6.9 1.1 9.6 6.9 1.6 1 0 0 1 1 1 0 C1 domain zf-RING_9 PF13901.6 VDM91396.1 - 0.69 9.9 5.9 1.3 9.0 5.9 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon PHD_2 PF13831.6 VDM91396.1 - 0.93 9.1 6.2 1.9 8.1 6.2 1.5 1 0 0 1 1 1 0 PHD-finger CAP_GLY PF01302.25 VDM91398.1 - 2.9e-12 46.4 1.4 3.8e-12 46.0 1.3 1.3 1 1 0 1 1 1 1 CAP-Gly domain Y_phosphatase PF00102.27 VDM91401.1 - 2.5e-38 132.0 0.5 1.3e-37 129.7 0.0 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase FERM_M PF00373.18 VDM91401.1 - 1.6e-14 54.3 0.1 7.9e-14 52.1 0.1 2.3 1 0 0 1 1 1 1 FERM central domain FERM_N PF09379.10 VDM91401.1 - 3.1e-08 33.4 0.1 1e-07 31.8 0.1 1.9 1 0 0 1 1 1 1 FERM N-terminal domain FERM_C PF09380.10 VDM91401.1 - 0.033 14.6 2.6 0.047 14.1 0.2 2.5 3 0 0 3 3 3 0 FERM C-terminal PH-like domain YBD PF17725.1 VDM91419.1 - 1.3e-86 289.7 0.1 1.7e-86 289.3 0.1 1.1 1 0 0 1 1 1 1 YAP binding domain TEA PF01285.18 VDM91419.1 - 6.1e-13 48.6 0.6 1.3e-12 47.6 0.6 1.5 1 0 0 1 1 1 1 TEA/ATTS domain HNF_C PF09354.10 VDM91419.1 - 0.057 14.5 1.3 0.07 14.2 0.1 1.8 2 0 0 2 2 2 0 HNF3 C-terminal domain Ribosomal_L4 PF00573.22 VDM91423.1 - 2e-37 128.8 1.3 2.2e-37 128.6 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 VDM91423.1 - 6.2e-23 80.7 1.8 1.5e-22 79.4 1.8 1.7 1 0 0 1 1 1 1 60S ribosomal protein L4 C-terminal domain DUF1936 PF09151.10 VDM91423.1 - 0.12 12.3 0.1 17 5.4 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) RRM_1 PF00076.22 VDM91425.1 - 3.5e-13 49.2 0.0 4.9e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 VDM91425.1 - 0.011 15.7 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain SET_assoc PF11767.8 VDM91425.1 - 0.17 11.5 0.1 0.35 10.5 0.1 1.5 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated GRP PF07172.11 VDM91425.1 - 0.6 10.8 26.8 0.044 14.5 22.1 1.6 2 0 0 2 2 2 0 Glycine rich protein family Transformer PF06495.11 VDM91425.1 - 1.6 8.8 15.0 2.7 8.0 15.0 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein Corona_nucleoca PF00937.18 VDM91425.1 - 5.9 5.8 10.6 8 5.4 10.6 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein REC114-like PF15165.6 VDM91427.1 - 0.014 15.2 1.2 0.021 14.6 1.2 1.3 1 1 0 1 1 1 0 Meiotic recombination protein REC114-like Me-amine-dh_L PF02975.14 VDM91427.1 - 0.021 15.3 1.1 0.043 14.3 0.1 2.0 2 1 1 3 3 3 0 Methylamine dehydrogenase, L chain A_deaminase PF00962.22 VDM91429.1 - 4.5e-69 233.3 0.0 5.2e-69 233.1 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 VDM91429.1 - 0.027 13.8 0.1 0.17 11.2 0.0 2.2 2 1 0 2 2 2 0 Amidohydrolase family Metallophos PF00149.28 VDM91436.1 - 4.8e-06 27.2 1.6 1.9e-05 25.2 1.6 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Tmemb_170 PF10190.9 VDM91437.1 - 8.8e-27 93.6 14.7 1.3e-26 93.0 14.7 1.3 1 0 0 1 1 1 1 Putative transmembrane protein 170 TFIIS_C PF01096.18 VDM91437.1 - 4.4e-14 52.0 5.5 4.4e-14 52.0 5.5 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) DZR PF12773.7 VDM91437.1 - 0.0052 16.8 7.1 0.97 9.5 7.1 2.8 1 1 0 1 1 1 1 Double zinc ribbon TackOD1 PF18551.1 VDM91437.1 - 0.013 15.2 3.3 0.037 13.7 0.5 2.1 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 zf_UBZ PF18439.1 VDM91437.1 - 0.099 12.3 4.7 5.1 6.8 0.0 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger NOB1_Zn_bind PF08772.11 VDM91437.1 - 0.11 12.7 3.4 2.8 8.2 0.1 2.4 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Rpr2 PF04032.16 VDM91437.1 - 0.12 12.7 8.1 0.22 11.8 2.5 2.4 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain PolC_DP2 PF03833.13 VDM91437.1 - 0.2 9.5 1.6 0.24 9.2 1.6 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 XAF1_C PF18608.1 VDM91437.1 - 0.23 11.1 0.3 0.23 11.1 0.3 2.4 3 1 0 3 3 3 0 XIAP-associated factor 1 C-terminal domain ADK_lid PF05191.14 VDM91437.1 - 0.27 11.3 4.5 0.36 10.8 0.1 2.8 3 0 0 3 3 3 0 Adenylate kinase, active site lid Baculo_LEF5_C PF11792.8 VDM91437.1 - 0.37 10.5 7.4 0.37 10.5 3.5 2.9 2 1 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain zf-ribbon_3 PF13248.6 VDM91437.1 - 0.51 9.8 8.0 6.1 6.4 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-HIT PF04438.16 VDM91437.1 - 1.2 9.1 10.6 2.7 7.9 0.6 3.1 3 0 0 3 3 3 0 HIT zinc finger RNA_POL_M_15KD PF02150.16 VDM91437.1 - 4 7.4 7.6 11 6.0 0.0 3.4 3 1 1 4 4 3 0 RNA polymerases M/15 Kd subunit MFS_1 PF07690.16 VDM91443.1 - 3e-47 161.3 31.1 3e-47 161.3 31.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1980 PF09323.10 VDM91443.1 - 0.62 9.9 2.3 0.64 9.9 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF2417 PF10329.9 VDM91443.1 - 2.6 7.4 8.2 1.8 7.9 5.6 2.0 1 1 0 1 1 1 0 Region of unknown function (DUF2417) INTS5_C PF14838.6 VDM91445.1 - 2.4e-171 571.9 3.6 3.3e-171 571.4 3.6 1.1 1 0 0 1 1 1 1 Integrator complex subunit 5 C-terminus INTS5_N PF14837.6 VDM91445.1 - 2.7e-49 167.7 0.5 2.2e-48 164.6 0.1 2.6 2 0 0 2 2 2 1 Integrator complex subunit 5 N-terminus MIEAP PF16026.5 VDM91445.1 - 0.1 12.8 0.3 12 6.1 0.1 2.7 2 0 0 2 2 2 0 Mitochondria-eating protein Ala_racemase_N PF01168.20 VDM91445.1 - 0.11 12.1 0.0 0.68 9.5 0.0 2.1 2 0 0 2 2 2 0 Alanine racemase, N-terminal domain AXH PF08517.12 VDM91449.1 - 4e-36 124.1 0.0 8.6e-36 123.0 0.0 1.6 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) HA2 PF04408.23 VDM91449.1 - 0.69 10.2 5.0 1.7 9.0 0.1 2.7 3 0 0 3 3 3 0 Helicase associated domain (HA2) Na_H_Exchanger PF00999.21 VDM91452.1 - 3.4e-79 266.4 40.7 4.4e-79 266.0 40.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family E1-E2_ATPase PF00122.20 VDM91454.1 - 1.3e-28 99.8 12.8 1e-20 74.0 1.4 3.0 2 1 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 VDM91454.1 - 4.6e-18 64.7 0.0 1e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 VDM91454.1 - 4.2e-15 55.6 0.3 1.2e-14 54.2 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) DUF4231 PF14015.6 VDM91454.1 - 0.023 15.2 0.8 4.1 7.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Phage_holin_3_6 PF07332.11 VDM91454.1 - 0.093 12.8 2.0 0.95 9.5 0.2 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2976 PF11190.8 VDM91454.1 - 4.6 7.1 9.1 0.85 9.5 0.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2976) APC_u5 PF16630.5 VDM91458.1 - 1.1 10.4 4.9 0.35 11.9 0.5 2.4 2 1 1 3 3 3 0 Unstructured region on APC between 1st and 2nd catenin-bdg motifs DUF3811 PF11656.8 VDM91458.1 - 1.9 9.0 8.3 1.9 8.9 4.5 2.7 2 1 1 3 3 3 0 YjbD family (DUF3811) DUF724 PF05266.14 VDM91458.1 - 6.5 6.5 13.3 0.91 9.3 6.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF724) JAKMIP_CC3 PF16034.5 VDM91459.1 - 0.0086 16.1 4.3 0.0086 16.1 4.3 4.8 2 1 2 4 4 4 1 JAKMIP CC3 domain DUF1192 PF06698.11 VDM91459.1 - 3.3 7.9 20.6 0.12 12.4 1.9 5.2 6 0 0 6 6 6 0 Protein of unknown function (DUF1192) DUF2721 PF11026.8 VDM91459.1 - 3.7 7.5 4.2 10 6.0 3.0 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) CD20 PF04103.15 VDM91461.1 - 1.4e-14 54.5 3.9 1.4e-14 54.5 3.9 2.2 2 1 0 2 2 2 1 CD20-like family PHtD_u1 PF16645.5 VDM91461.1 - 0.12 12.8 0.0 0.25 11.8 0.0 1.4 1 0 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein DUF4728 PF15860.5 VDM91463.1 - 0.00073 20.2 0.4 0.0013 19.4 0.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4728) Mtp PF03821.16 VDM91463.1 - 0.062 12.9 1.9 1.6 8.3 0.2 2.0 1 1 1 2 2 2 0 Golgi 4-transmembrane spanning transporter DHHC PF01529.20 VDM91463.1 - 0.57 10.3 6.6 0.51 10.4 5.1 1.8 1 1 0 1 1 1 0 DHHC palmitoyltransferase CUE PF02845.16 VDM91464.1 - 1.4e-08 34.3 0.1 2.9e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 CUE domain zf-RING_2 PF13639.6 VDM91464.1 - 0.00012 22.3 2.9 0.00035 20.8 2.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 VDM91464.1 - 0.00038 20.7 3.2 0.0012 19.1 2.6 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 VDM91464.1 - 0.041 13.7 3.7 0.23 11.3 3.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDM91464.1 - 0.15 11.9 1.3 0.32 10.9 1.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 VDM91464.1 - 0.21 11.2 2.5 0.25 11.0 0.6 2.0 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type RBD PF02196.15 VDM91465.1 - 0.00038 20.5 0.0 0.00047 20.2 0.0 1.0 1 0 0 1 1 1 1 Raf-like Ras-binding domain CP2 PF04516.15 VDM91466.1 - 2.5e-58 197.1 0.5 2.5e-58 197.1 0.5 2.6 3 0 0 3 3 3 1 CP2 transcription factor DUF4770 PF15994.5 VDM91466.1 - 0.0063 16.8 5.2 0.0063 16.8 5.2 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4770) PPL5 PF18168.1 VDM91466.1 - 0.44 9.8 9.3 0.021 14.1 2.1 2.1 2 0 0 2 2 2 0 Prim-pol family 5 V_ATPase_I PF01496.19 VDM91466.1 - 2.1 6.1 13.1 0.0095 13.9 3.9 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF5308 PF17233.2 VDM91466.1 - 3.6 7.8 16.5 0.061 13.5 5.5 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5308) SpoIIP PF07454.11 VDM91466.1 - 4 6.8 20.2 0.13 11.6 9.9 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) DUF4338 PF14236.6 VDM91466.1 - 5.2 6.2 10.9 0.37 10.0 4.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4338) DUF719 PF05334.13 VDM91466.1 - 5.7 7.1 13.7 0.51 10.5 5.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF719) RR_TM4-6 PF06459.12 VDM91466.1 - 5.8 6.7 18.7 0.42 10.4 10.8 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 VDM91466.1 - 6.6 5.4 23.4 0.59 8.8 13.9 2.1 2 0 0 2 2 2 0 Presenilin DUF702 PF05142.12 VDM91466.1 - 9 6.8 15.9 7.6 7.0 9.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF702) Cytochrom_B558a PF05038.13 VDM91466.1 - 9.9 5.7 5.9 2.5 7.6 2.6 1.6 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit Glycogen_syn PF05693.13 VDM91474.1 - 0 1011.2 0.2 0 1011.0 0.2 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 VDM91474.1 - 2.3e-06 27.3 0.0 0.00013 21.6 0.0 2.8 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 VDM91474.1 - 1.6e-05 25.3 0.0 0.004 17.6 0.0 3.2 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 VDM91474.1 - 0.014 15.4 0.1 0.039 14.0 0.1 1.7 1 0 0 1 1 1 0 Glycosyltransferase Family 4 zf-C4 PF00105.18 VDM91476.1 - 9.5e-30 102.9 12.2 1.6e-29 102.2 12.2 1.3 1 0 0 1 1 1 1 Zinc finger, C4 type (two domains) Pkinase_C PF00433.24 VDM91476.1 - 0.053 14.2 0.1 0.16 12.7 0.1 1.9 1 1 0 1 1 1 0 Protein kinase C terminal domain LIM PF00412.22 VDM91479.1 - 8.6e-34 115.6 28.1 3.8e-14 52.6 3.1 3.1 3 0 0 3 3 3 3 LIM domain zf-dskA_traR PF01258.17 VDM91479.1 - 0.028 14.4 3.2 0.028 14.4 3.2 5.7 5 2 1 6 6 6 0 Prokaryotic dksA/traR C4-type zinc finger Pkinase PF00069.25 VDM91480.1 - 4.9e-66 222.8 0.0 6.1e-66 222.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM91480.1 - 2.4e-29 102.4 0.0 3.3e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDM91480.1 - 2.9e-08 33.4 0.0 3.6e-07 29.8 0.0 2.0 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDM91480.1 - 0.00016 20.5 0.0 0.00042 19.2 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 VDM91480.1 - 0.013 14.8 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 VDM91480.1 - 0.027 14.1 0.3 9.4 5.8 0.1 2.5 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 VDM91480.1 - 0.031 14.2 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Snapin_Pallidin PF14712.6 VDM91481.1 - 9.2e-05 22.8 0.8 0.00013 22.3 0.8 1.2 1 0 0 1 1 1 1 Snapin/Pallidin CENP-F_leu_zip PF10473.9 VDM91481.1 - 0.01 15.9 1.0 0.012 15.7 1.0 1.1 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-H2C2_2 PF13465.6 VDM91482.1 - 1.4e-15 56.9 21.2 1.8e-08 34.4 0.8 4.4 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 VDM91482.1 - 6.7e-09 35.7 31.2 0.00028 21.2 1.8 5.0 5 0 0 5 5 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDM91482.1 - 8.3e-08 32.4 23.8 0.0057 17.4 1.0 5.7 5 0 0 5 5 5 3 C2H2-type zinc finger zf-BED PF02892.15 VDM91482.1 - 0.041 13.9 0.2 0.041 13.9 0.2 3.7 1 1 3 4 4 4 0 BED zinc finger zf-Di19 PF05605.12 VDM91482.1 - 0.089 13.1 17.9 4.3 7.7 1.1 3.6 2 2 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 VDM91482.1 - 1.5 9.0 14.4 0.41 10.8 3.9 3.2 2 1 0 2 2 2 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 VDM91482.1 - 1.8 9.0 15.7 5.3 7.4 1.5 3.5 1 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) XPA_N PF01286.18 VDM91482.1 - 2.4 8.3 7.5 4.6 7.4 0.1 3.5 3 0 0 3 3 3 0 XPA protein N-terminal zf-C2H2_jaz PF12171.8 VDM91482.1 - 5.7 7.4 9.0 8.3 6.8 0.1 4.1 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 VDM91482.1 - 6.9 7.5 11.2 45 4.9 4.5 3.3 1 1 1 2 2 2 0 zinc-ribbon family zf-nanos PF05741.13 VDM91482.1 - 9.3 6.6 9.7 19 5.6 0.3 2.8 2 0 0 2 2 2 0 Nanos RNA binding domain FeoB_associated PF12669.7 VDM91484.1 - 0.11 12.9 0.3 0.31 11.5 0.3 1.8 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein TPR_1 PF00515.28 VDM91486.1 - 5.2e-42 140.0 34.9 2.2e-05 24.1 0.0 16.0 17 0 0 17 17 16 7 Tetratricopeptide repeat TPR_2 PF07719.17 VDM91486.1 - 2.4e-40 133.4 41.2 0.00021 21.2 0.1 15.9 17 0 0 17 17 15 9 Tetratricopeptide repeat TPR_8 PF13181.6 VDM91486.1 - 1.7e-29 99.5 28.4 0.00039 20.4 0.1 13.6 14 0 0 14 14 14 6 Tetratricopeptide repeat TPR_19 PF14559.6 VDM91486.1 - 3e-29 101.3 20.8 8.3e-06 26.2 0.0 11.6 12 1 2 14 14 14 6 Tetratricopeptide repeat TPR_12 PF13424.6 VDM91486.1 - 1.1e-28 99.3 29.6 1.2e-05 25.5 0.3 11.2 9 4 2 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 VDM91486.1 - 6.4e-28 95.1 18.8 0.017 15.9 0.0 13.9 9 4 6 15 15 13 6 Tetratricopeptide repeat TPR_16 PF13432.6 VDM91486.1 - 6.8e-25 87.4 0.4 6e-08 33.2 0.0 9.7 10 1 1 11 11 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 VDM91486.1 - 1.6e-21 75.7 14.3 0.028 14.1 0.0 11.6 11 1 1 12 12 11 6 TPR repeat TPR_17 PF13431.6 VDM91486.1 - 3.4e-20 70.9 25.1 0.25 11.8 0.2 15.4 17 0 0 17 17 16 5 Tetratricopeptide repeat TPR_7 PF13176.6 VDM91486.1 - 9.1e-19 66.0 18.1 0.0044 16.9 0.0 12.0 13 0 0 13 13 11 3 Tetratricopeptide repeat TPR_10 PF13374.6 VDM91486.1 - 1.2e-18 66.3 17.4 0.00094 19.0 0.0 12.3 14 0 0 14 14 13 4 Tetratricopeptide repeat TPR_6 PF13174.6 VDM91486.1 - 2.5e-14 52.8 34.1 0.072 13.8 0.1 13.5 14 1 1 15 15 14 5 Tetratricopeptide repeat TPR_9 PF13371.6 VDM91486.1 - 1.2e-10 41.4 9.4 0.0046 17.1 0.1 8.1 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_4 PF07721.14 VDM91486.1 - 1.3e-07 31.6 0.6 2.1 9.2 0.0 7.0 7 0 0 7 7 6 1 Tetratricopeptide repeat Rapsyn_N PF10579.9 VDM91486.1 - 2.4e-07 30.7 0.3 0.2 11.8 0.0 4.8 5 0 0 5 5 4 2 Rapsyn N-terminal myristoylation and linker region ANAPC3 PF12895.7 VDM91486.1 - 4.5e-05 23.6 30.3 0.0017 18.5 2.6 7.7 5 3 3 9 9 9 4 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 VDM91486.1 - 0.0092 16.0 19.7 0.15 12.2 0.2 7.2 8 0 0 8 8 8 1 Fis1 C-terminal tetratricopeptide repeat TPR_3 PF07720.12 VDM91486.1 - 0.14 12.2 25.1 12 6.0 0.0 7.9 9 0 0 9 9 8 0 Tetratricopeptide repeat DUF4810 PF16068.5 VDM91486.1 - 0.38 11.3 0.0 0.38 11.3 0.0 5.0 5 1 1 6 6 3 0 Domain of unknown function (DUF4810) CCP_MauG PF03150.14 VDM91486.1 - 1 10.0 5.5 0.3 11.7 0.1 2.8 3 0 0 3 3 3 0 Di-haem cytochrome c peroxidase MAS20 PF02064.15 VDM91486.1 - 1.3 9.1 0.0 1.3 9.1 0.0 4.9 6 1 1 7 7 2 0 MAS20 protein import receptor Homeodomain PF00046.29 VDM91487.1 - 5.7e-21 74.1 2.9 5.7e-21 74.1 2.9 1.8 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 VDM91487.1 - 0.0039 17.0 0.0 0.011 15.6 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homez PF11569.8 VDM91487.1 - 0.061 12.8 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez HTH_AsnC-type PF13404.6 VDM91487.1 - 0.15 11.9 0.7 2.3 8.1 0.1 2.5 2 0 0 2 2 2 0 AsnC-type helix-turn-helix domain Peptidase_M14 PF00246.24 VDM91496.1 - 1e-85 288.1 0.0 1.7e-85 287.3 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 VDM91496.1 - 2.3e-18 66.3 0.0 8e-18 64.6 0.0 2.0 2 0 0 2 2 2 1 Carboxypeptidase activation peptide SBP_bac_6 PF13343.6 VDM91496.1 - 0.013 15.0 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein CLASP_N PF12348.8 VDM91501.1 - 2.4e-11 43.6 0.2 3.2e-11 43.3 0.2 1.1 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.22 VDM91501.1 - 7e-09 35.2 1.0 0.00057 19.9 0.0 4.6 6 0 0 6 6 5 2 HEAT repeat Vac14_Fab1_bd PF12755.7 VDM91501.1 - 1.2e-07 32.2 0.0 6.2e-05 23.5 0.0 2.8 1 1 2 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 VDM91501.1 - 3.3e-07 30.6 0.0 0.00097 19.5 0.0 2.7 1 1 1 2 2 2 2 HEAT repeats Adaptin_N PF01602.20 VDM91501.1 - 4.3e-05 22.3 0.3 5.4e-05 21.9 0.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_EZ PF13513.6 VDM91501.1 - 0.00043 20.7 0.3 0.0035 17.8 0.0 2.5 3 1 0 3 3 3 1 HEAT-like repeat Cnd1 PF12717.7 VDM91501.1 - 0.0071 16.4 0.9 0.045 13.8 0.2 2.2 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.6 VDM91501.1 - 0.044 13.4 0.4 9.5 5.7 0.0 2.9 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.8 VDM91501.1 - 0.065 13.4 0.7 0.38 10.9 0.3 2.3 1 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair Tti2 PF10521.9 VDM91501.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 Tti2 family SIL1 PF16782.5 VDM91501.1 - 0.3 10.3 0.0 0.3 10.3 0.0 2.0 2 1 0 3 3 3 0 Nucleotide exchange factor SIL1 CLASP_N PF12348.8 VDM91502.1 - 2.4e-11 43.6 0.2 3.2e-11 43.3 0.2 1.1 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.22 VDM91502.1 - 7e-09 35.2 1.0 0.00057 19.9 0.0 4.6 6 0 0 6 6 5 2 HEAT repeat Vac14_Fab1_bd PF12755.7 VDM91502.1 - 1.2e-07 32.2 0.0 6.2e-05 23.5 0.0 2.8 1 1 2 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 VDM91502.1 - 3.3e-07 30.6 0.0 0.00097 19.5 0.0 2.7 1 1 1 2 2 2 2 HEAT repeats Adaptin_N PF01602.20 VDM91502.1 - 4.3e-05 22.3 0.3 5.4e-05 21.9 0.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_EZ PF13513.6 VDM91502.1 - 0.00043 20.7 0.3 0.0035 17.8 0.0 2.5 3 1 0 3 3 3 1 HEAT-like repeat Cnd1 PF12717.7 VDM91502.1 - 0.0071 16.4 0.9 0.045 13.8 0.2 2.2 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.6 VDM91502.1 - 0.044 13.4 0.4 9.5 5.7 0.0 2.9 3 0 0 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II TAN PF11640.8 VDM91502.1 - 0.065 13.4 0.7 0.38 10.9 0.3 2.3 1 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair Tti2 PF10521.9 VDM91502.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.7 2 0 0 2 2 2 0 Tti2 family SIL1 PF16782.5 VDM91502.1 - 0.3 10.3 0.0 0.3 10.3 0.0 2.0 2 1 0 3 3 3 0 Nucleotide exchange factor SIL1 AA_permease PF00324.21 VDM91506.1 - 1.9e-44 152.1 17.2 1.4e-39 136.1 3.7 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 VDM91506.1 - 5e-44 151.0 5.4 1.6e-17 63.7 2.6 3.1 2 1 1 3 3 3 3 Solute carrier family 12 RasGEF PF00617.19 VDM91510.1 - 3e-35 122.0 1.1 8.3e-35 120.6 0.8 1.9 1 1 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 VDM91510.1 - 5.6e-12 45.8 0.3 1.7e-11 44.3 0.3 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif Thymidylat_synt PF00303.19 VDM91513.1 - 5.3e-110 366.8 0.0 6e-110 366.6 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase BTB PF00651.31 VDM91514.1 - 3.7e-09 36.8 0.3 2e-08 34.4 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain DUF1265 PF06887.14 VDM91514.1 - 0.014 15.4 1.0 0.026 14.5 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1265) Tim29 PF10171.9 VDM91514.1 - 0.14 11.7 0.1 1.3 8.5 0.1 2.2 2 0 0 2 2 2 0 Translocase of the Inner Mitochondrial membrane 29 CD20 PF04103.15 VDM91519.1 - 5.2e-09 36.4 9.0 0.0001 22.4 0.6 2.1 1 1 1 2 2 2 2 CD20-like family Rab_bind PF16704.5 VDM91521.1 - 5.7e-12 45.5 6.8 5.7e-12 45.5 6.8 4.6 4 0 0 4 4 4 1 Rab binding domain GRIP PF01465.20 VDM91521.1 - 0.015 15.2 1.8 0.5 10.3 0.5 3.4 3 0 0 3 3 3 0 GRIP domain DUF3563 PF12086.8 VDM91521.1 - 2.1 8.2 5.2 0.69 9.7 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3563) MARVEL PF01284.23 VDM91525.1 - 0.023 14.7 0.1 0.025 14.6 0.1 1.1 1 0 0 1 1 1 0 Membrane-associating domain DUF3357 PF11837.8 VDM91525.1 - 0.35 11.4 4.6 0.37 11.3 4.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3357) MHYT PF03707.16 VDM91525.1 - 0.46 10.7 6.9 0.54 10.5 6.9 1.3 1 1 0 1 1 1 0 Bacterial signalling protein N terminal repeat Ig_3 PF13927.6 VDM91526.1 - 4.5e-15 56.0 0.1 1.4e-09 38.4 0.0 3.8 3 0 0 3 3 3 2 Immunoglobulin domain I-set PF07679.16 VDM91526.1 - 2.8e-12 46.6 0.1 4.4e-10 39.5 0.0 3.4 3 1 0 3 3 3 1 Immunoglobulin I-set domain Ig_2 PF13895.6 VDM91526.1 - 4.9e-12 46.0 0.0 0.00011 22.5 0.0 3.4 3 0 0 3 3 3 2 Immunoglobulin domain ig PF00047.25 VDM91526.1 - 2e-11 43.9 3.2 1.9e-06 28.0 0.0 4.2 4 1 0 4 4 4 2 Immunoglobulin domain V-set PF07686.17 VDM91526.1 - 2.8e-05 24.2 0.4 0.0087 16.2 0.1 3.6 3 1 0 3 3 3 1 Immunoglobulin V-set domain Ig_6 PF18452.1 VDM91526.1 - 0.06 12.9 0.0 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 Immunoglobulin domain Anoctamin PF04547.12 VDM91533.1 - 6.2e-70 236.3 0.5 7.7e-70 236.0 0.5 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel KdgM PF06178.13 VDM91533.1 - 0.011 15.4 0.9 2.9 7.5 0.1 2.2 2 0 0 2 2 2 0 Oligogalacturonate-specific porin protein (KdgM) MAT1 PF06391.13 VDM91535.1 - 0.00084 19.2 7.2 0.00084 19.2 7.2 2.0 2 0 0 2 2 2 1 CDK-activating kinase assembly factor MAT1 Spt20 PF12090.8 VDM91535.1 - 0.002 17.8 28.8 0.0076 15.9 20.4 2.2 2 0 0 2 2 2 2 Spt20 family HDV_ag PF01517.18 VDM91535.1 - 0.027 14.3 0.1 0.043 13.6 0.1 1.3 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Mak10 PF04112.13 VDM91535.1 - 0.074 12.6 4.2 0.25 10.8 1.5 2.1 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase MTABC_N PF16185.5 VDM91535.1 - 0.39 10.2 1.6 0.79 9.2 1.6 1.4 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region LCD1 PF09798.9 VDM91535.1 - 0.41 9.1 5.3 0.51 8.8 5.3 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein TCP PF03634.13 VDM91535.1 - 0.96 10.0 15.4 1.9 9.0 4.6 2.4 2 0 0 2 2 2 0 TCP family transcription factor FHIPEP PF00771.20 VDM91535.1 - 1.6 7.1 5.9 0.2 10.1 1.9 1.4 2 0 0 2 2 2 0 FHIPEP family Gastrin PF00918.17 VDM91535.1 - 3.1 8.8 12.1 1.3 10.0 4.5 2.4 2 0 0 2 2 2 0 Gastrin/cholecystokinin family Roughex PF06020.11 VDM91535.1 - 3.4 6.7 14.5 0.23 10.5 8.4 1.9 2 0 0 2 2 2 0 Drosophila roughex protein MPM1 PF17234.2 VDM91535.1 - 3.6 7.8 11.4 0.87 9.8 7.4 1.9 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Ly49 PF08391.10 VDM91535.1 - 4.4 7.7 10.0 1.6 9.1 7.0 1.7 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region dsDNA_bind PF01984.20 VDM91535.1 - 4.6 7.6 26.0 6.3 7.1 18.8 2.6 2 0 0 2 2 2 0 Double-stranded DNA-binding domain YABBY PF04690.13 VDM91535.1 - 5.5 7.5 8.9 1.5 9.4 3.2 2.2 2 0 0 2 2 2 0 YABBY protein TERB2 PF15101.6 VDM91535.1 - 6.8 6.7 11.8 1.1 9.2 5.7 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 SNF PF00209.18 VDM91539.1 - 1e-109 367.6 26.8 4.1e-109 365.6 26.8 1.7 1 1 0 1 1 1 1 Sodium:neurotransmitter symporter family SET PF00856.28 VDM91540.1 - 1.8e-17 64.2 0.1 7.9e-17 62.2 0.1 2.0 1 1 0 1 1 1 1 SET domain Patched PF02460.18 VDM91541.1 - 1.5e-14 53.1 14.0 2e-14 52.7 14.0 1.2 1 0 0 1 1 1 1 Patched family DUF4131 PF13567.6 VDM91541.1 - 5.5 6.6 7.9 2.3 7.8 3.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Oxidored_FMN PF00724.20 VDM91542.1 - 7.7e-22 78.0 3.2 1.3e-21 77.2 0.0 2.7 2 1 0 2 2 2 1 NADH:flavin oxidoreductase / NADH oxidase family I_LWEQ PF01608.17 VDM91542.1 - 5.7 7.2 12.3 0.75 10.0 6.5 2.6 3 0 0 3 3 3 0 I/LWEQ domain AMP-binding PF00501.28 VDM91544.1 - 2.4e-86 290.0 0.0 2e-85 286.9 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 VDM91544.1 - 9.1e-16 58.6 0.1 2.7e-15 57.1 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Arrestin_C PF02752.22 VDM91545.1 - 7.1e-05 23.3 0.3 0.0002 21.8 0.1 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain BBL5 PF07289.11 VDM91546.1 - 4.4e-132 440.1 0.0 5e-132 440.0 0.0 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein bPH_3 PF14470.6 VDM91546.1 - 0.004 17.5 0.0 0.0077 16.6 0.0 1.5 1 0 0 1 1 1 1 Bacterial PH domain Collagen PF01391.18 VDM91547.1 - 2.1e-25 88.2 88.5 4e-10 39.3 32.5 3.4 3 0 0 3 3 3 3 Collagen triple helix repeat (20 copies) FoP_duplication PF13865.6 VDM91552.1 - 0.031 14.8 0.0 0.031 14.8 0.0 3.3 3 0 0 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 TraB PF01963.17 VDM91554.1 - 3.8e-31 109.0 0.0 4.3e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 TraB family 23S_rRNA_IVP PF05635.11 VDM91554.1 - 0.023 15.0 0.1 0.058 13.7 0.0 1.8 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein An_peroxidase PF03098.15 VDM91555.1 - 1.6e-09 36.9 0.0 2e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase An_peroxidase PF03098.15 VDM91557.1 - 4.2e-21 75.1 0.2 1e-10 40.8 0.0 2.0 1 1 1 2 2 2 2 Animal haem peroxidase DeoC PF01791.9 VDM91559.1 - 2e-26 93.1 0.3 2.3e-26 92.9 0.3 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase Pom PF17251.2 VDM91559.1 - 0.018 14.3 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 Protochlamydia outer membrane protein Pyr_redox_2 PF07992.14 VDM91560.1 - 3.5e-29 102.0 0.5 5.1e-14 52.2 0.1 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 VDM91560.1 - 1.3e-06 28.2 0.0 7.7e-06 25.7 0.0 2.3 2 0 0 2 2 2 1 Rubredoxin NAD+ reductase C-terminal domain K_oxygenase PF13434.6 VDM91560.1 - 0.00037 19.7 0.3 0.0015 17.8 0.0 1.9 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 VDM91560.1 - 0.0014 19.2 1.3 2.4 8.8 0.3 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 VDM91560.1 - 0.0016 18.8 0.4 2.5 8.6 0.1 3.0 3 0 0 3 3 3 2 Putative NAD(P)-binding TPP_enzyme_M PF00205.22 VDM91560.1 - 0.0078 15.9 0.1 0.58 9.9 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Arylesterase PF01731.20 VDM91561.1 - 7.6 6.8 9.1 0.18 12.0 0.5 2.6 4 0 0 4 4 4 0 Arylesterase SUZ PF12752.7 VDM91563.1 - 1.1e-15 58.1 0.1 1.1e-15 58.1 0.1 2.2 2 0 0 2 2 2 1 SUZ domain GIDA_assoc PF13932.6 VDM91563.1 - 0.12 12.5 2.7 0.16 12.2 2.7 1.1 1 0 0 1 1 1 0 GidA associated domain Cytomega_UL84 PF06284.11 VDM91563.1 - 9.9 4.5 6.2 4.3 5.7 3.7 1.5 1 1 1 2 2 2 0 Cytomegalovirus UL84 protein AAA PF00004.29 VDM91564.1 - 8.3e-45 152.5 0.1 2.9e-44 150.7 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 VDM91564.1 - 1.4e-11 44.1 0.1 6.8e-11 42.0 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 VDM91564.1 - 2.9e-10 39.8 0.0 1e-09 38.0 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 VDM91564.1 - 1.2e-08 35.0 0.1 4.7e-08 33.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 VDM91564.1 - 1.4e-08 35.0 0.1 4.6e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 VDM91564.1 - 6.2e-06 26.7 0.5 0.0019 18.6 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 VDM91564.1 - 5.1e-05 23.1 0.0 0.00019 21.2 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 VDM91564.1 - 8.9e-05 21.8 0.2 0.00018 20.7 0.0 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 VDM91564.1 - 0.00014 21.9 0.0 0.0024 17.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 VDM91564.1 - 0.00021 21.6 0.0 0.00054 20.3 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_22 PF13401.6 VDM91564.1 - 0.00024 21.4 1.1 0.075 13.3 0.1 2.7 1 1 1 2 2 2 1 AAA domain NTPase_1 PF03266.15 VDM91564.1 - 0.00029 20.8 0.1 0.062 13.2 0.0 3.1 3 0 0 3 3 3 1 NTPase AAA_28 PF13521.6 VDM91564.1 - 0.00045 20.5 0.1 0.0011 19.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 VDM91564.1 - 0.00046 19.6 0.1 0.0011 18.4 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 VDM91564.1 - 0.00073 20.1 0.0 0.0019 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 VDM91564.1 - 0.0012 19.1 0.0 0.0026 17.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Bac_DnaA PF00308.18 VDM91564.1 - 0.0048 16.8 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein NACHT PF05729.12 VDM91564.1 - 0.0081 16.1 0.1 0.057 13.3 0.0 2.2 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 VDM91564.1 - 0.0088 15.8 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein TsaE PF02367.17 VDM91564.1 - 0.012 15.6 0.0 0.029 14.4 0.0 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 VDM91564.1 - 0.012 15.5 0.1 0.098 12.6 0.1 2.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_3 PF07726.11 VDM91564.1 - 0.015 15.2 0.0 0.13 12.1 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 VDM91564.1 - 0.018 14.3 0.0 0.039 13.1 0.0 1.6 1 0 0 1 1 1 0 TIP49 P-loop domain TniB PF05621.11 VDM91564.1 - 0.018 14.4 0.2 1.8 8.0 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein Sigma54_activat PF00158.26 VDM91564.1 - 0.025 14.3 0.3 0.77 9.4 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 VDM91564.1 - 0.031 13.5 0.0 0.07 12.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin ATPase PF06745.13 VDM91564.1 - 0.033 13.6 0.6 1.2 8.5 0.0 2.8 3 0 0 3 3 3 0 KaiC Prot_ATP_OB_N PF17758.1 VDM91564.1 - 0.033 13.8 0.1 0.22 11.2 0.0 2.3 3 0 0 3 3 2 0 Proteasomal ATPase OB N-terminal domain AAA_7 PF12775.7 VDM91564.1 - 0.041 13.4 0.1 0.25 10.8 0.1 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_17 PF13207.6 VDM91564.1 - 0.048 14.1 0.0 0.2 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 VDM91564.1 - 0.057 13.1 0.1 0.14 11.9 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 VDM91564.1 - 0.072 12.7 0.2 0.072 12.7 0.2 2.3 2 1 1 3 3 2 0 AAA domain PhoH PF02562.16 VDM91564.1 - 0.098 12.1 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 VDM91564.1 - 0.12 12.8 0.0 0.4 11.2 0.0 2.1 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 VDM91564.1 - 0.13 11.4 0.1 0.52 9.5 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 VDM91564.1 - 0.14 11.8 0.1 0.36 10.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain SWIRM-assoc_1 PF16495.5 VDM91564.1 - 0.49 10.4 4.9 1.3 9.0 4.9 1.7 1 0 0 1 1 1 0 SWIRM-associated region 1 Chromadorea_ALT PF05535.12 VDM91568.1 - 2.1e-32 111.2 10.5 2.6e-32 110.8 10.5 1.1 1 0 0 1 1 1 1 Chromadorea ALT protein Nop14 PF04147.12 VDM91568.1 - 0.23 9.6 5.1 0.24 9.5 5.1 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 VDM91568.1 - 3.5 5.8 5.1 3.9 5.7 5.1 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 VDM91568.1 - 4.2 6.4 12.6 4.7 6.2 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RSN1_7TM PF02714.15 VDM91570.1 - 0.037 13.3 0.1 0.046 13.0 0.1 1.1 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate DOMON PF03351.17 VDM91572.1 - 5e-07 30.0 0.0 6.5e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 DOMON domain ING PF12998.7 VDM91573.1 - 1.9e-22 79.7 2.4 3.9e-22 78.7 2.4 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 VDM91573.1 - 1.8e-06 27.7 11.6 3.4e-06 26.9 11.6 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 VDM91573.1 - 0.00059 19.3 3.3 0.001 18.5 3.3 1.4 1 0 0 1 1 1 1 PHD-finger V_ATPase_I PF01496.19 VDM91573.1 - 0.034 12.1 2.6 0.042 11.8 2.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family C9orf72-like PF15019.6 VDM91573.1 - 0.047 13.3 0.3 0.078 12.5 0.3 1.4 1 0 0 1 1 1 0 C9orf72-like protein family zf-HC5HC2H PF13771.6 VDM91573.1 - 0.15 12.3 6.5 0.45 10.8 6.5 1.9 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-C4pol PF14260.6 VDM91573.1 - 2.2 8.8 8.3 1.4 9.4 1.3 2.9 3 0 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta RNA_pol_Rpb4 PF03874.16 VDM91577.1 - 1.3e-24 86.9 4.7 1.8e-24 86.4 4.7 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 Tfb4 PF03850.14 VDM91577.1 - 0.0044 16.6 0.1 0.0047 16.5 0.1 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 TetR_C_36 PF18598.1 VDM91577.1 - 0.037 14.0 0.1 0.054 13.5 0.1 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain MIF4G_like_2 PF09090.11 VDM91577.1 - 0.074 12.5 3.5 0.81 9.1 0.2 2.1 2 0 0 2 2 2 0 MIF4G like EF-G-binding_N PF07299.11 VDM91577.1 - 0.14 12.7 2.2 0.32 11.5 0.8 2.3 1 1 0 1 1 1 0 Elongation factor G-binding protein, N-terminal HIG_1_N PF04588.13 VDM91578.1 - 0.032 14.4 1.9 0.032 14.4 1.9 2.5 2 1 0 2 2 2 0 Hypoxia induced protein conserved region KASH PF10541.9 VDM91581.1 - 7.1e-15 55.0 5.0 1.2e-14 54.3 5.0 1.3 1 0 0 1 1 1 1 Nuclear envelope localisation domain Sec34 PF04136.15 VDM91581.1 - 0.0021 18.0 9.4 0.14 12.0 3.2 3.6 3 1 1 4 4 4 2 Sec34-like family NAGidase PF07555.13 VDM91581.1 - 0.011 15.1 0.2 0.017 14.5 0.2 1.2 1 0 0 1 1 1 0 beta-N-acetylglucosaminidase DUF4107 PF13389.6 VDM91581.1 - 0.013 15.7 0.3 0.027 14.6 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4107) DUF5112 PF17139.4 VDM91581.1 - 0.057 12.9 1.6 1.8 7.9 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5112) AHD PF17793.1 VDM91581.1 - 0.098 12.5 0.7 1.3 8.9 0.0 3.0 3 0 0 3 3 3 0 ANC1 homology domain (AHD) RNA_pol_Rpb1_5 PF04998.17 VDM91581.1 - 0.18 11.2 0.4 0.27 10.6 0.4 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 FlaC_arch PF05377.11 VDM91581.1 - 0.34 11.4 12.3 2.1 8.8 0.2 4.5 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) YojJ PF10372.9 VDM91581.1 - 0.79 9.9 4.9 1.2 9.2 0.2 3.4 2 1 2 4 4 4 0 Bacterial membrane-spanning protein N-terminus eIF3_N PF09440.10 VDM91581.1 - 1.6 9.2 9.0 4.8 7.6 1.4 3.2 3 1 1 4 4 4 0 eIF3 subunit 6 N terminal domain Baculo_PEP_C PF04513.12 VDM91581.1 - 1.7 8.7 8.2 5.9 6.9 4.8 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Baculo_p24 PF05073.12 VDM91581.1 - 2.1 8.1 6.4 2.4 7.9 0.3 2.7 1 1 1 2 2 2 0 Baculovirus P24 capsid protein DUF4709 PF15821.5 VDM91581.1 - 2.6 8.4 7.2 0.3 11.4 1.1 2.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4709) Lipoprotein_7 PF01540.16 VDM91581.1 - 4.5 6.5 12.3 8.2 5.6 8.0 2.1 1 1 1 2 2 2 0 Adhesin lipoprotein KH_1 PF00013.29 VDM91582.1 - 9.4e-10 38.2 3.7 6.1e-09 35.6 0.5 3.0 2 1 1 3 3 3 1 KH domain DUF2171 PF09939.9 VDM91582.1 - 0.071 13.4 0.1 0.24 11.7 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2171) YqzE PF14038.6 VDM91582.1 - 0.3 11.1 5.0 1.5 8.9 0.3 2.5 2 0 0 2 2 2 0 YqzE-like protein Neur_chan_memb PF02932.16 VDM91585.1 - 0.026 14.6 0.3 0.031 14.4 0.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SRP-alpha_N PF04086.13 VDM91585.1 - 0.039 13.9 4.1 0.053 13.4 4.1 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Cofilin_ADF PF00241.20 VDM91590.1 - 4.5e-58 194.3 5.4 1.6e-30 105.4 0.3 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Pro_isomerase PF00160.21 VDM91592.1 - 1.6e-37 129.2 0.0 1.8e-37 129.0 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Sin3_corepress PF08295.12 VDM91596.1 - 0.0011 19.1 2.9 0.0037 17.3 2.9 1.9 1 0 0 1 1 1 1 Sin3 family co-repressor MAP65_ASE1 PF03999.12 VDM91599.1 - 6.5e-40 137.4 19.3 5e-30 104.8 11.0 2.4 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) Streptin-Immun PF11083.8 VDM91599.1 - 0.25 11.8 7.6 11 6.5 0.8 3.8 3 1 0 3 3 3 0 Lantibiotic streptin immunity protein DUF489 PF04356.12 VDM91599.1 - 0.46 10.5 1.9 11 6.0 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF489) TOPRIM_C PF16898.5 VDM91599.1 - 1.5 9.1 6.8 0.089 13.1 0.5 2.0 2 0 0 2 2 2 0 C-terminal associated domain of TOPRIM FKBP_C PF00254.28 VDM91606.1 - 0.01 16.1 0.0 0.017 15.4 0.0 1.5 1 1 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_11 PF13414.6 VDM91606.1 - 0.063 13.0 0.5 0.11 12.2 0.5 1.4 1 0 0 1 1 1 0 TPR repeat zf-C3HC4 PF00097.25 VDM91607.1 - 6.4e-07 29.1 6.3 1.2e-06 28.3 6.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDM91607.1 - 6.5e-07 29.6 6.9 1.2e-06 28.7 6.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 VDM91607.1 - 1.5e-05 24.8 7.3 2.9e-05 23.8 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 VDM91607.1 - 2.8e-05 23.9 5.2 5e-05 23.1 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 VDM91607.1 - 0.00043 20.5 8.5 0.0014 18.9 8.5 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 VDM91607.1 - 0.012 15.5 4.5 0.026 14.5 4.5 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_10 PF16685.5 VDM91607.1 - 0.13 12.4 3.8 0.29 11.3 3.8 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 VDM91607.1 - 0.15 12.0 6.6 0.3 11.0 6.6 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 VDM91607.1 - 0.19 11.8 3.7 0.18 11.9 2.0 1.8 1 1 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 VDM91607.1 - 0.33 11.0 3.9 0.91 9.6 3.9 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 VDM91607.1 - 0.47 10.4 5.1 0.34 10.8 3.0 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-AD PF07776.15 VDM91607.1 - 0.74 10.1 3.3 2.6 8.3 3.3 2.0 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) zf-C3HC4_4 PF15227.6 VDM91607.1 - 6.9 6.9 7.4 15 5.8 7.4 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING FAM176 PF14851.6 VDM91608.1 - 3e-05 23.7 1.3 3.4e-05 23.6 1.3 1.1 1 0 0 1 1 1 1 FAM176 family DUF2457 PF10446.9 VDM91608.1 - 0.0017 17.6 20.3 0.0017 17.6 20.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) RXT2_N PF08595.11 VDM91608.1 - 0.0021 18.1 4.4 0.0023 18.0 4.4 1.1 1 0 0 1 1 1 1 RXT2-like, N-terminal DUF2615 PF11027.8 VDM91608.1 - 0.0028 17.8 3.7 0.0043 17.2 3.7 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2615) NOA36 PF06524.12 VDM91608.1 - 0.0043 16.4 18.6 0.0048 16.3 18.6 1.1 1 0 0 1 1 1 1 NOA36 protein TRAP_alpha PF03896.16 VDM91608.1 - 0.011 15.0 6.3 0.013 14.8 6.3 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sigma70_ner PF04546.13 VDM91608.1 - 0.031 14.1 8.0 0.032 14.1 8.0 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region RSN1_TM PF13967.6 VDM91608.1 - 0.033 14.0 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport CobT PF06213.12 VDM91608.1 - 0.038 13.4 4.4 0.04 13.3 4.4 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 VDM91608.1 - 0.042 12.0 17.8 0.045 11.9 17.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi TFB6 PF17110.5 VDM91608.1 - 0.063 13.0 5.1 0.068 12.9 5.1 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Dicty_REP PF05086.12 VDM91608.1 - 0.11 10.5 6.7 0.11 10.4 6.7 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4834 PF16118.5 VDM91608.1 - 0.12 13.4 0.3 0.18 12.8 0.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) DUF4484 PF14831.6 VDM91608.1 - 0.2 11.7 5.7 0.21 11.6 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF2428 PF10350.9 VDM91608.1 - 0.32 10.2 1.2 0.36 10.0 1.2 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) SDA1 PF05285.12 VDM91608.1 - 0.33 10.3 10.8 0.38 10.1 10.8 1.1 1 0 0 1 1 1 0 SDA1 Sporozoite_P67 PF05642.11 VDM91608.1 - 0.41 8.7 5.9 0.41 8.7 5.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PPP4R2 PF09184.11 VDM91608.1 - 0.44 10.1 9.8 0.47 10.0 9.8 1.1 1 0 0 1 1 1 0 PPP4R2 Conotoxin PF02950.17 VDM91608.1 - 0.78 10.8 10.3 3.5 8.7 10.3 1.9 1 1 0 1 1 1 0 Conotoxin DUF1449 PF07290.11 VDM91608.1 - 0.98 9.0 5.7 1 8.9 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1449) CDC45 PF02724.14 VDM91608.1 - 1.1 7.5 12.5 1.2 7.3 12.5 1.0 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 VDM91608.1 - 1.1 7.7 13.3 1.1 7.7 13.3 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SGT1 PF07093.11 VDM91608.1 - 1.3 7.4 10.8 1.4 7.3 10.8 1.0 1 0 0 1 1 1 0 SGT1 protein Tmemb_9 PF05434.11 VDM91608.1 - 1.5 8.7 7.0 0.75 9.7 5.3 1.4 1 1 0 1 1 1 0 TMEM9 Utp14 PF04615.13 VDM91608.1 - 1.7 7.2 10.8 1.8 7.0 10.8 1.0 1 0 0 1 1 1 0 Utp14 protein DUF3295 PF11702.8 VDM91608.1 - 1.7 7.9 11.0 1.8 7.9 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) ANAPC15 PF15243.6 VDM91608.1 - 3.6 8.0 16.9 4.9 7.6 16.9 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 RNA_pol_3_Rpc31 PF11705.8 VDM91608.1 - 4 7.6 18.6 4.2 7.6 18.6 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Astro_capsid_p PF12226.8 VDM91608.1 - 4.5 6.3 10.0 4.4 6.4 10.0 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2722 PF10846.8 VDM91608.1 - 4.9 6.0 8.6 5.2 5.9 8.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Cwf_Cwc_15 PF04889.12 VDM91608.1 - 6 6.5 24.5 8.5 6.0 24.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4576 PF15144.6 VDM91608.1 - 6.9 6.6 14.2 49 3.9 14.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4576) Nop14 PF04147.12 VDM91608.1 - 9.3 4.3 15.9 11 4.0 15.9 1.0 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.6 VDM91608.1 - 9.8 6.5 19.1 16 5.8 19.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) Ig_3 PF13927.6 VDM91610.1 - 7e-15 55.4 0.0 2.4e-13 50.5 0.0 2.4 2 1 0 2 2 2 1 Immunoglobulin domain Ig_2 PF13895.6 VDM91610.1 - 3.3e-12 46.6 0.0 7.3e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 VDM91610.1 - 5.6e-10 39.2 0.0 8.6e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Immunoglobulin I-set domain ig PF00047.25 VDM91610.1 - 5.3e-08 32.9 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Immunoglobulin domain V-set PF07686.17 VDM91610.1 - 3.5e-05 23.9 0.1 0.0017 18.5 0.1 2.6 2 1 0 2 2 2 1 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDM91610.1 - 0.00052 20.0 0.7 0.021 14.9 0.0 2.6 3 0 0 3 3 3 1 CD80-like C2-set immunoglobulin domain CDP-OH_P_transf PF01066.21 VDM91612.1 - 2.8e-14 53.6 0.2 2.8e-14 53.6 0.2 3.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase COX14 PF14880.6 VDM91612.1 - 0.011 15.5 2.1 0.039 13.8 2.1 1.9 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Nucleotid_trans PF03407.16 VDM91614.1 - 2e-36 126.0 0.3 3e-36 125.4 0.3 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase CDK5_activator PF03261.15 VDM91618.1 - 6e-69 233.3 8.0 2e-68 231.6 8.0 1.8 1 1 0 1 1 1 1 Cyclin-dependent kinase 5 activator protein RE_Alw26IDE PF09665.10 VDM91618.1 - 0.026 13.7 0.1 0.04 13.1 0.1 1.2 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) DUF4808 PF16066.5 VDM91618.1 - 0.068 13.7 1.9 0.14 12.7 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4808) V-set PF07686.17 VDM91620.1 - 3.4e-16 59.4 0.5 2.9e-09 37.1 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin V-set domain I-set PF07679.16 VDM91620.1 - 5.2e-15 55.3 0.1 2.9e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 VDM91620.1 - 2.2e-14 53.8 0.2 2.6e-07 31.2 0.0 2.3 2 0 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 VDM91620.1 - 1.9e-13 50.4 0.5 1.1e-05 25.5 0.1 2.2 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 VDM91620.1 - 3.1e-08 33.8 0.2 4.6e-05 23.7 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain V-set_CD47 PF08204.11 VDM91620.1 - 6.5e-07 29.4 1.2 0.0016 18.5 0.4 2.2 1 1 1 2 2 2 2 CD47 immunoglobulin-like domain Ig_4 PF16680.5 VDM91620.1 - 1.5e-05 25.2 0.7 0.021 15.1 0.0 3.4 2 2 0 2 2 2 1 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 VDM91620.1 - 8.6e-05 22.0 0.0 0.17 11.5 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_5 PF16681.5 VDM91620.1 - 0.00083 19.7 1.2 0.89 10.0 0.2 3.3 2 2 0 2 2 2 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 VDM91620.1 - 0.00092 19.2 0.3 1.1 9.4 0.1 2.9 2 2 0 2 2 2 2 Izumo-like Immunoglobulin domain C1-set PF07654.15 VDM91620.1 - 0.0095 16.3 0.3 0.11 12.9 0.0 2.3 2 1 0 2 2 2 1 Immunoglobulin C1-set domain Adeno_E3_CR1 PF02440.15 VDM91620.1 - 0.022 14.5 0.3 2.2 8.1 0.0 2.3 2 0 0 2 2 2 0 Adenovirus E3 region protein CR1 Acetyltransf_5 PF13444.6 VDM91620.1 - 0.098 13.4 0.0 0.62 10.8 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Receptor_2B4 PF11465.8 VDM91620.1 - 0.12 12.6 0.0 0.85 9.8 0.0 2.2 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 DB PF01682.19 VDM91625.1 - 9.1e-19 67.6 14.3 1.3e-18 67.2 14.3 1.2 1 0 0 1 1 1 1 DB module HECT PF00632.25 VDM91638.1 - 1.1e-95 320.6 1.5 2.3e-95 319.6 1.5 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TIM21 PF08294.11 VDM91639.1 - 7e-24 84.4 0.0 9.6e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 VDM91639.1 - 0.0008 19.1 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 mRNA_decap_C PF16741.5 VDM91640.1 - 6.4e-06 25.4 0.1 1.2e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 mRNA-decapping enzyme C-terminus Tmp39 PF10271.9 VDM91645.1 - 1.7e-97 327.2 15.7 1.5e-70 238.4 11.6 2.0 2 0 0 2 2 2 2 Putative transmembrane protein POT1PC PF16686.5 VDM91646.1 - 6e-25 87.9 0.0 3.2e-24 85.5 0.0 2.0 2 0 0 2 2 2 1 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 VDM91646.1 - 2.4e-12 46.9 0.1 8e-11 42.0 0.0 2.6 3 0 0 3 3 3 1 Telomeric single stranded DNA binding POT1/CDC13 CDC24_OB3 PF17244.2 VDM91646.1 - 0.17 11.6 0.2 2.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 Cauli_VI PF01693.16 VDM91649.1 - 4.5e-31 106.9 9.6 2.5e-17 62.9 2.5 2.5 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 VDM91650.1 - 4.4e-28 98.3 0.9 3.8e-27 95.2 0.0 2.5 2 1 1 3 3 3 1 RNase H RVT_3 PF13456.6 VDM91650.1 - 9.8e-10 38.3 0.0 2e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase-like Translin PF01997.16 VDM91650.1 - 0.096 12.7 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Translin family RrnaAD PF00398.20 VDM91652.1 - 4.2e-61 206.3 0.1 5.2e-61 206.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 VDM91652.1 - 8.1e-08 32.9 0.0 1.7e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 VDM91652.1 - 2.2e-06 28.2 0.0 5.1e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDM91652.1 - 0.0004 20.2 0.0 0.0007 19.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 VDM91652.1 - 0.00054 20.6 0.0 0.0011 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 VDM91652.1 - 0.00084 19.3 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 VDM91652.1 - 0.0032 16.8 0.0 0.0066 15.8 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 VDM91652.1 - 0.0055 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 VDM91652.1 - 0.012 14.7 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase UPF0020 PF01170.18 VDM91652.1 - 0.022 14.4 0.0 0.045 13.4 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 MTS PF05175.14 VDM91652.1 - 0.024 14.2 0.0 0.061 12.9 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_4 PF02390.17 VDM91652.1 - 0.047 13.2 0.0 0.087 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_23 PF13489.6 VDM91652.1 - 0.052 13.4 0.0 0.12 12.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 VDM91652.1 - 0.058 13.4 0.1 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain IFN-gamma PF00714.17 VDM91653.1 - 0.0033 17.3 0.0 0.0041 17.0 0.0 1.1 1 0 0 1 1 1 1 Interferon gamma Z1 PF10593.9 VDM91661.1 - 0.061 12.8 0.3 0.071 12.6 0.3 1.1 1 0 0 1 1 1 0 Z1 domain T3SSipB PF16535.5 VDM91661.1 - 0.076 13.5 0.2 0.094 13.2 0.2 1.1 1 0 0 1 1 1 0 Type III cell invasion protein SipB 7tm_1 PF00001.21 VDM91662.1 - 2.1e-40 138.8 13.9 2.5e-40 138.5 13.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDM91662.1 - 2.3e-07 30.5 8.6 3.8e-07 29.8 8.6 1.3 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 VDM91662.1 - 0.00026 20.8 3.0 0.0004 20.2 3.0 1.3 1 0 0 1 1 1 1 Olfactory receptor DUF3561 PF12084.8 VDM91662.1 - 0.047 13.7 1.7 0.088 12.8 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3561) DUF2116 PF09889.9 VDM91662.1 - 0.072 13.1 0.6 0.46 10.5 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MadM PF03818.13 VDM91662.1 - 2.2 8.2 7.2 14 5.7 0.1 3.5 3 1 1 4 4 4 0 Malonate/sodium symporter MadM subunit WD40 PF00400.32 VDM91666.1 - 0.033 15.1 5.9 0.96 10.4 0.1 4.8 6 0 0 6 6 6 0 WD domain, G-beta repeat Nup160 PF11715.8 VDM91666.1 - 0.14 10.8 1.0 0.27 9.8 0.2 1.7 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF1287 PF06940.11 VDM91670.1 - 0.086 12.5 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) F-box-like PF12937.7 VDM91673.1 - 1.1e-07 31.6 0.6 2.8e-07 30.3 0.6 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 VDM91673.1 - 7.5e-07 28.9 1.9 2.3e-06 27.3 1.9 1.9 1 0 0 1 1 1 1 F-box domain Period_C PF12114.8 VDM91673.1 - 1.3 8.6 6.0 1.2 8.6 3.9 1.8 2 0 0 2 2 2 0 Period protein 2/3C-terminal region Band_7 PF01145.25 VDM91676.1 - 1.3e-30 106.7 0.5 1.6e-30 106.4 0.5 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 VDM91676.1 - 0.00063 19.5 0.2 0.00088 19.0 0.2 1.2 1 0 0 1 1 1 1 SPFH domain-Band 7 family HSP20 PF00011.21 VDM91677.1 - 1e-11 44.8 0.1 1.4e-11 44.4 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 VDM91677.1 - 0.11 12.0 0.1 0.44 10.1 0.0 1.9 2 0 0 2 2 2 0 HSP20-like domain found in ArsA Synaphin PF05835.12 VDM91681.1 - 1.1e-35 123.0 11.1 1.4e-35 122.7 11.1 1.0 1 0 0 1 1 1 1 Synaphin protein SseC PF04888.12 VDM91681.1 - 0.1 12.2 0.7 0.17 11.5 0.7 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Atrophin-1 PF03154.15 VDM91681.1 - 1.1 7.5 4.0 0.97 7.6 4.0 1.0 1 0 0 1 1 1 0 Atrophin-1 family Ribosomal_S17 PF00366.20 VDM91685.1 - 0.098 12.8 0.5 0.28 11.3 0.5 1.7 1 0 0 1 1 1 0 Ribosomal protein S17 IQ PF00612.27 VDM91690.1 - 3.7e-14 51.1 1.3 2.3e-06 26.9 0.0 2.7 2 0 0 2 2 2 2 IQ calmodulin-binding motif RIIa PF02197.17 VDM91690.1 - 9e-06 25.3 0.1 1.9e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Band_3_cyto PF07565.13 VDM91690.1 - 0.021 14.6 0.9 0.021 14.6 0.9 1.6 1 1 1 2 2 2 0 Band 3 cytoplasmic domain Band_7 PF01145.25 VDM91690.1 - 0.036 14.1 0.2 0.35 10.9 0.0 2.2 1 1 1 2 2 2 0 SPFH domain / Band 7 family TTR-52 PF01060.23 VDM91692.1 - 6.1e-12 46.1 0.0 2.2e-11 44.3 0.0 2.0 2 1 0 2 2 2 1 Transthyretin-like family TTR-52 PF01060.23 VDM91693.1 - 4.3e-20 72.2 0.0 7.9e-20 71.4 0.0 1.4 1 1 0 1 1 1 1 Transthyretin-like family DsbC_N PF10411.9 VDM91693.1 - 0.035 13.5 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 Disulfide bond isomerase protein N-terminus PAS_3 PF08447.12 VDM91699.1 - 1.9e-10 40.9 0.1 0.00024 21.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 VDM91699.1 - 2e-10 40.8 0.2 1.1e-06 28.8 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 VDM91699.1 - 1.9e-09 37.5 0.0 5.6e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 VDM91699.1 - 7.9e-05 22.9 0.0 0.00035 20.8 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 VDM91699.1 - 0.00019 21.6 0.0 0.023 14.9 0.0 2.5 2 0 0 2 2 2 1 PAS fold DNA_pol_phi PF04931.13 VDM91701.1 - 0.19 9.8 38.5 0.2 9.7 38.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi HSP90 PF00183.18 VDM91701.1 - 0.57 9.0 6.4 0.62 8.9 6.4 1.0 1 0 0 1 1 1 0 Hsp90 protein TFB6 PF17110.5 VDM91701.1 - 1.1 9.0 15.3 1.3 8.8 15.3 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CDC45 PF02724.14 VDM91701.1 - 1.1 7.4 23.3 1.1 7.4 23.3 1.0 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 VDM91701.1 - 1.2 8.5 19.9 1.3 8.3 19.9 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 VDM91701.1 - 1.4 7.0 26.5 1.3 7.1 26.5 1.0 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.13 VDM91701.1 - 1.9 8.3 22.1 2.3 8.0 22.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4637 PF15470.6 VDM91701.1 - 2.4 7.9 13.0 2.6 7.8 13.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Mpp10 PF04006.12 VDM91701.1 - 4.3 5.7 22.0 4.3 5.7 22.0 1.0 1 0 0 1 1 1 0 Mpp10 protein SspB PF04386.13 VDM91701.1 - 7 6.5 6.9 8.2 6.3 6.9 1.1 1 0 0 1 1 1 0 Stringent starvation protein B DUF2796 PF10986.8 VDM91701.1 - 8.9 6.3 9.8 11 6.0 9.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) PRIMA1 PF16101.5 VDM91703.1 - 7.1 6.7 11.3 17 5.5 11.3 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ARID PF01388.21 VDM91705.1 - 6e-21 74.9 0.2 1.2e-20 74.0 0.2 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain R3H-assoc PF13902.6 VDM91707.1 - 9.1e-31 107.0 0.6 1.4e-30 106.4 0.6 1.3 1 0 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.22 VDM91707.1 - 0.042 13.8 0.0 0.14 12.2 0.0 2.0 1 0 0 1 1 1 0 R3H domain Herpes_UL14 PF03580.14 VDM91707.1 - 0.1 12.8 1.5 0.18 12.0 1.5 1.4 1 0 0 1 1 1 0 Herpesvirus UL14-like protein Pkinase PF00069.25 VDM91711.1 - 1.7e-15 57.1 0.0 2e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM91711.1 - 1.8e-09 37.3 0.0 2.8e-09 36.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDM91711.1 - 0.0036 16.2 0.0 0.0042 15.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 VDM91711.1 - 0.006 16.5 0.0 0.24 11.3 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 VDM91713.1 - 1.1e-17 64.2 0.0 1.5e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM91713.1 - 9e-09 35.0 0.0 1.2e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase I-set PF07679.16 VDM91716.1 - 2.6e-36 123.5 0.0 2.9e-11 43.3 0.0 3.7 3 1 0 3 3 3 3 Immunoglobulin I-set domain Ig_3 PF13927.6 VDM91716.1 - 8.7e-35 119.2 0.0 1.4e-10 41.6 0.0 3.7 3 0 0 3 3 3 3 Immunoglobulin domain Ig_2 PF13895.6 VDM91716.1 - 4e-26 91.1 0.2 1.8e-07 31.4 0.0 4.5 4 1 0 4 4 3 3 Immunoglobulin domain ig PF00047.25 VDM91716.1 - 1.9e-25 88.8 0.0 4e-08 33.3 0.0 4.0 3 1 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 VDM91716.1 - 5.2e-19 68.4 0.0 5.1e-06 26.6 0.0 4.4 3 1 1 4 4 4 4 Immunoglobulin V-set domain Ig_5 PF16681.5 VDM91716.1 - 1.9e-08 34.6 0.0 0.1 13.0 0.0 4.2 4 0 0 4 4 4 2 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Ig_4 PF16680.5 VDM91716.1 - 4.5e-06 26.8 0.0 1.1 9.6 0.0 4.3 4 1 0 4 4 4 2 T-cell surface glycoprotein CD3 delta chain Ig_6 PF18452.1 VDM91716.1 - 3.6e-05 23.3 0.0 0.94 9.1 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Receptor_2B4 PF11465.8 VDM91716.1 - 0.00013 22.1 0.1 0.055 13.7 0.0 3.0 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 C2-set_2 PF08205.12 VDM91716.1 - 0.00026 21.0 0.0 0.024 14.7 0.0 2.7 2 0 0 2 2 2 1 CD80-like C2-set immunoglobulin domain Izumo-Ig PF16706.5 VDM91716.1 - 0.00036 20.5 0.0 3.2 7.9 0.0 3.5 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain C1-set PF07654.15 VDM91716.1 - 0.15 12.5 1.2 8.4 6.9 0.0 3.9 4 2 0 4 4 4 0 Immunoglobulin C1-set domain PH PF00169.29 VDM91717.1 - 9.9e-10 38.9 0.1 1.4e-09 38.4 0.1 1.2 1 0 0 1 1 1 1 PH domain DUF2076 PF09849.9 VDM91717.1 - 4.1e-07 30.3 4.8 6.2e-07 29.7 4.8 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Myb_DNA-bind_5 PF13873.6 VDM91719.1 - 2.8e-05 24.1 2.7 0.00039 20.4 0.2 3.2 3 0 0 3 3 3 1 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 VDM91719.1 - 0.039 14.3 0.1 0.13 12.6 0.1 1.9 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Ion_trans_2 PF07885.16 VDM91721.1 - 1.1e-13 50.9 10.8 1e-09 38.2 4.6 2.3 2 0 0 2 2 2 2 Ion channel Cytokin_check_N PF10407.9 VDM91721.1 - 0.066 13.2 0.3 0.28 11.2 0.4 2.0 2 0 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus EHD_N PF16880.5 VDM91724.1 - 0.027 14.3 6.5 6.6 6.7 0.0 4.2 4 0 0 4 4 4 0 N-terminal EH-domain containing protein Pkinase PF00069.25 VDM91731.1 - 2.4e-14 53.4 0.0 4.4e-14 52.5 0.0 1.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM91731.1 - 3.6e-06 26.5 0.0 5.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDM91731.1 - 0.0038 16.1 0.6 0.0057 15.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Acetyltransf_18 PF18014.1 VDM91738.1 - 2.3e-06 27.5 0.0 3.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TPR_12 PF13424.6 VDM91740.1 - 2.4e-64 213.6 23.7 1.1e-19 70.4 1.4 4.9 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 VDM91740.1 - 2.6e-59 195.6 16.7 4e-14 52.0 0.0 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 VDM91740.1 - 8.9e-31 103.7 19.4 3.1e-06 26.8 0.1 6.9 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 VDM91740.1 - 7.1e-26 88.9 34.1 1.8e-07 30.7 0.2 6.8 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 VDM91740.1 - 8.1e-21 72.4 27.3 0.00014 21.7 1.7 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 VDM91740.1 - 1.1e-14 53.3 25.1 0.014 15.6 1.4 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_MalT PF17874.1 VDM91740.1 - 3.6e-14 52.9 0.4 3.6e-14 52.9 0.4 2.6 3 0 0 3 3 2 1 MalT-like TPR region TPR_16 PF13432.6 VDM91740.1 - 8e-12 45.6 14.4 0.0027 18.3 0.1 5.7 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 VDM91740.1 - 4.1e-10 40.0 14.2 0.0023 18.4 0.2 4.8 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 VDM91740.1 - 7.4e-10 38.5 7.6 0.15 12.5 0.1 6.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDM91740.1 - 1.3e-09 38.0 12.1 0.41 11.6 0.0 6.6 3 1 3 6 6 6 1 Tetratricopeptide repeat TPR_4 PF07721.14 VDM91740.1 - 8e-06 26.0 0.0 14 6.6 0.1 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 VDM91740.1 - 2.5e-05 24.4 10.7 0.01 16.0 0.2 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 VDM91740.1 - 0.00065 19.8 1.0 1.3 9.4 0.0 4.9 6 0 0 6 6 5 1 PPR repeat JIP_LZII PF16471.5 VDM91740.1 - 0.0027 17.9 2.5 0.0027 17.9 2.5 2.9 3 0 0 3 3 3 1 JNK-interacting protein leucine zipper II NUDE_C PF04880.13 VDM91740.1 - 0.012 16.1 0.6 0.012 16.1 0.6 1.8 2 0 0 2 2 1 0 NUDE protein, C-terminal conserved region Csm1_N PF18504.1 VDM91740.1 - 0.035 14.4 6.4 0.12 12.7 5.4 2.6 1 1 0 1 1 1 0 Csm1 N-terminal domain TPR_11 PF13414.6 VDM91740.1 - 0.05 13.3 0.5 0.05 13.3 0.5 6.1 6 1 1 7 7 6 0 TPR repeat SHNi-TPR PF10516.9 VDM91740.1 - 0.084 12.3 3.1 2.8 7.5 0.1 3.9 4 0 0 4 4 4 0 SHNi-TPR PPR_2 PF13041.6 VDM91740.1 - 0.19 12.0 0.2 39 4.5 0.0 3.1 2 0 0 2 2 2 0 PPR repeat family Wzy_C_2 PF11846.8 VDM91740.1 - 0.23 11.4 5.0 9.1 6.2 0.0 3.8 4 1 1 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal TPR_3 PF07720.12 VDM91740.1 - 0.25 11.4 13.7 1.1 9.3 0.4 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat COG2 PF06148.11 VDM91740.1 - 0.42 10.7 5.3 0.51 10.4 3.6 2.0 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RasGAP_C PF03836.15 VDM91740.1 - 0.85 9.8 11.4 0.085 13.0 5.8 2.2 2 0 0 2 2 2 0 RasGAP C-terminus TMF_TATA_bd PF12325.8 VDM91740.1 - 0.87 9.8 15.4 0.021 15.0 6.7 2.8 3 0 0 3 3 2 0 TATA element modulatory factor 1 TATA binding Mod_r PF07200.13 VDM91740.1 - 1.2 9.3 15.2 5.6 7.1 10.8 3.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF627 PF04781.12 VDM91740.1 - 1.2 9.2 8.6 8.4 6.5 0.1 4.5 4 1 1 5 5 4 0 Protein of unknown function (DUF627) V_ATPase_I PF01496.19 VDM91740.1 - 1.7 6.5 5.7 2.5 5.9 5.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 VDM91740.1 - 1.7 7.4 18.2 0.81 8.5 15.7 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein CENP-K PF11802.8 VDM91740.1 - 2.8 7.4 13.3 6.8 6.2 13.3 1.6 1 0 0 1 1 1 0 Centromere-associated protein K CLZ PF16526.5 VDM91740.1 - 4.7 7.6 9.3 2.8 8.4 4.4 3.1 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YabA PF06156.13 VDM91740.1 - 6.5 7.4 14.9 2.9 8.6 7.3 3.7 2 1 1 3 3 3 0 Initiation control protein YabA C2 PF00168.30 VDM91743.1 - 6.5e-28 97.1 0.1 1.5e-27 95.9 0.1 1.6 1 0 0 1 1 1 1 C2 domain C1_1 PF00130.22 VDM91743.1 - 5.5e-14 51.8 4.4 1.2e-13 50.6 4.4 1.7 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Ion_trans PF00520.31 VDM91745.1 - 5.5e-38 130.6 10.1 7.5e-38 130.1 10.1 1.2 1 0 0 1 1 1 1 Ion transport protein BTB_2 PF02214.22 VDM91745.1 - 4.9e-19 68.5 0.0 1.3e-18 67.1 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain Ion_trans_2 PF07885.16 VDM91745.1 - 6.3e-14 51.7 8.7 2e-13 50.1 8.7 1.9 1 0 0 1 1 1 1 Ion channel BTB_3 PF16017.5 VDM91745.1 - 0.02 15.0 0.0 0.053 13.6 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain DUF423 PF04241.15 VDM91745.1 - 0.059 13.6 0.5 0.14 12.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF423) DUF3855 PF12967.7 VDM91745.1 - 0.081 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) PKD_channel PF08016.12 VDM91745.1 - 0.31 9.7 9.6 0.054 12.2 3.9 2.1 2 0 0 2 2 2 0 Polycystin cation channel ABC2_membrane_3 PF12698.7 VDM91750.1 - 0.23 10.5 0.4 0.27 10.3 0.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Pro_isomerase PF00160.21 VDM91751.1 - 2.4e-46 157.9 0.2 6.9e-46 156.4 0.1 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 VDM91751.1 - 6.7e-06 25.7 0.4 6.7e-06 25.7 0.4 2.2 2 1 0 2 2 2 1 Rtf2 RING-finger zf-Nse PF11789.8 VDM91751.1 - 0.013 15.3 0.1 0.13 12.1 0.1 2.6 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 VDM91751.1 - 0.016 15.4 0.0 0.087 13.0 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 VDM91751.1 - 0.037 14.2 0.0 0.34 11.1 0.0 2.6 2 0 0 2 2 2 0 U-box domain DUF4054 PF13262.6 VDM91751.1 - 0.073 13.1 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) PutA_N PF18083.1 VDM91753.1 - 0.024 14.7 0.1 0.035 14.1 0.1 1.4 1 0 0 1 1 1 0 Proline utilization A N-terminal domain Na_Ca_ex PF01699.24 VDM91755.1 - 6.7e-39 133.3 39.7 6.3e-28 97.6 18.7 3.3 2 1 1 3 3 3 2 Sodium/calcium exchanger protein Solute_trans_a PF03619.16 VDM91756.1 - 3.2e-20 72.8 15.4 4e-20 72.4 15.4 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF4718 PF15842.5 VDM91756.1 - 0.15 11.9 0.1 0.23 11.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Pkinase_Tyr PF07714.17 VDM91759.1 - 6.9e-21 74.7 0.1 1.7e-20 73.4 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase F5_F8_type_C PF00754.25 VDM91759.1 - 6.9e-17 61.8 0.0 1.1e-14 54.6 0.0 2.4 2 0 0 2 2 2 2 F5/8 type C domain Pkinase PF00069.25 VDM91759.1 - 2.9e-14 53.1 0.8 6.2e-14 52.0 0.8 1.5 1 0 0 1 1 1 1 Protein kinase domain SH3_13 PF18335.1 VDM91759.1 - 0.085 12.7 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain Transglut_core PF01841.19 VDM91762.1 - 1.1e-11 45.1 0.2 3.1e-11 43.7 0.2 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily Peptidase_M13_N PF05649.13 VDM91764.1 - 1.1e-10 41.8 0.4 1.3e-10 41.5 0.4 1.1 1 0 0 1 1 1 1 Peptidase family M13 DUF5466 PF17554.2 VDM91764.1 - 0.12 12.6 0.0 0.39 11.0 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5466) Glypican PF01153.19 VDM91766.1 - 2.8e-17 62.8 0.2 5.4e-17 61.8 0.2 1.5 1 1 0 1 1 1 1 Glypican Synaptobrevin PF00957.21 VDM91767.1 - 2.9e-20 71.8 1.3 3.9e-20 71.4 1.3 1.2 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 VDM91767.1 - 0.016 15.4 0.0 0.018 15.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter ANAPC4_WD40 PF12894.7 VDM91768.1 - 5e-06 26.7 0.0 2.3e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain UPF0184 PF03670.13 VDM91768.1 - 0.015 15.7 1.9 0.038 14.4 1.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) Lactonase PF10282.9 VDM91768.1 - 0.026 13.8 0.0 0.072 12.3 0.0 1.7 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller WD40 PF00400.32 VDM91768.1 - 0.087 13.7 1.5 0.57 11.2 0.1 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat NPV_P10 PF05531.12 VDM91768.1 - 0.16 12.5 0.0 0.16 12.5 0.0 3.1 5 0 0 5 5 5 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 VDM91770.1 - 7.9e-63 212.3 0.0 1.1e-62 211.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DCX PF03607.17 VDM91770.1 - 2.5e-34 117.1 0.2 3.4e-17 62.3 0.0 3.0 3 0 0 3 3 3 2 Doublecortin Pkinase_Tyr PF07714.17 VDM91770.1 - 2.2e-28 99.3 0.0 3.4e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDM91770.1 - 0.00011 21.2 0.0 0.0007 18.5 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 VDM91770.1 - 0.0051 16.2 0.0 0.014 14.8 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Y_phosphatase PF00102.27 VDM91772.1 - 5e-05 23.0 0.0 5.4e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF2738 PF10927.8 VDM91772.1 - 0.082 12.0 0.0 0.093 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2738) DivIC PF04977.15 VDM91777.1 - 0.016 15.0 2.0 0.016 15.0 2.0 2.3 2 0 0 2 2 2 0 Septum formation initiator bZIP_1 PF00170.21 VDM91777.1 - 0.027 14.6 2.2 0.027 14.6 2.2 2.5 2 1 0 2 2 2 0 bZIP transcription factor ZapB PF06005.12 VDM91777.1 - 0.063 13.7 5.3 0.21 12.1 5.3 1.9 1 0 0 1 1 1 0 Cell division protein ZapB JIP_LZII PF16471.5 VDM91777.1 - 0.11 12.7 5.5 0.53 10.5 4.2 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II HALZ PF02183.18 VDM91777.1 - 0.26 11.6 4.8 0.37 11.0 1.7 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper NRBF2 PF08961.10 VDM91777.1 - 0.46 10.1 6.9 0.093 12.3 2.6 2.0 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Fzo_mitofusin PF04799.13 VDM91777.1 - 7.5 6.1 10.1 0.18 11.3 3.4 1.7 2 0 0 2 2 2 0 fzo-like conserved region DUF1907 PF08925.11 VDM91778.1 - 0.0048 16.4 0.0 0.005 16.3 0.0 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1907) Metallophos PF00149.28 VDM91780.1 - 2e-40 139.5 0.1 2.8e-40 139.0 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 VDM91780.1 - 4.1e-23 81.6 1.8 6.4e-23 80.9 1.0 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain 7tm_1 PF00001.21 VDM91783.1 - 0.043 13.2 0.0 0.043 13.2 0.0 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Beta_helix PF13229.6 VDM91787.1 - 6.4e-10 39.1 2.1 1.1e-09 38.3 0.7 1.8 1 1 0 1 1 1 1 Right handed beta helix region F-box-like PF12937.7 VDM91787.1 - 5.7e-09 35.7 2.6 6.1e-09 35.6 0.1 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 VDM91787.1 - 4.9e-06 26.3 0.3 4.9e-06 26.3 0.3 2.9 3 0 0 3 3 3 1 F-box domain NosD PF05048.13 VDM91787.1 - 0.00037 19.8 0.1 0.00087 18.6 0.0 1.6 2 0 0 2 2 2 1 Periplasmic copper-binding protein (NosD) FERM_C PF09380.10 VDM91790.1 - 1.9e-21 76.3 0.0 4e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 FERM C-terminal PH-like domain FERM_N PF09379.10 VDM91790.1 - 5.6e-08 32.6 0.1 1.1e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 FERM N-terminal domain FERM_M PF00373.18 VDM91790.1 - 1.8e-05 25.2 0.0 4.7e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 FERM central domain SDA1 PF05285.12 VDM91792.1 - 0.43 10.0 10.3 0.4 10.1 10.3 1.0 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 VDM91792.1 - 0.92 7.6 9.8 0.86 7.7 9.8 1.0 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 VDM91792.1 - 1.1 7.2 23.3 1.5 6.8 23.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi Sigma70_ner PF04546.13 VDM91792.1 - 8.2 6.3 8.0 10 5.9 8.0 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region SR-25 PF10500.9 VDM91792.1 - 9.3 5.8 6.3 13 5.3 6.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GOLGA2L5 PF15070.6 VDM91793.1 - 2.8e-30 105.6 95.8 3.7e-22 78.8 6.0 5.1 1 1 0 3 3 3 2 Putative golgin subfamily A member 2-like protein 5 ZapB PF06005.12 VDM91793.1 - 0.021 15.2 0.9 0.021 15.2 0.9 12.0 4 3 6 10 10 10 0 Cell division protein ZapB DUF3556 PF12077.8 VDM91793.1 - 0.16 10.3 0.0 0.25 9.7 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein of unknown function (DUF3556) Methyltrans_SAM PF10672.9 VDM91794.1 - 0.073 12.2 0.0 0.087 12.0 0.0 1.1 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase Ammonium_transp PF00909.21 VDM91798.1 - 2.6e-95 319.5 16.4 3.1e-95 319.2 16.4 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Aminotran_5 PF00266.19 VDM91815.1 - 6.1e-06 25.4 0.0 6.9e-06 25.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_5 PF00266.19 VDM91816.1 - 6e-46 157.1 0.0 7.4e-46 156.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V CI-B14_5a PF07347.12 VDM91817.1 - 6.4e-14 51.6 5.2 1.4e-13 50.5 0.5 2.6 1 1 1 2 2 2 2 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Peptidase_M24 PF00557.24 VDM91825.1 - 1.8e-18 67.0 0.0 2e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3793 PF12672.7 VDM91825.1 - 0.092 12.8 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) BORA_N PF15280.6 VDM91827.1 - 6.9e-36 124.0 6.0 6.9e-36 124.0 6.0 1.8 2 0 0 2 2 2 1 Protein aurora borealis N-terminus PX PF00787.24 VDM91828.1 - 1.7e-20 73.1 1.0 3.3e-19 68.9 0.3 2.2 2 0 0 2 2 2 2 PX domain STAS PF01740.21 VDM91832.1 - 1.7e-17 63.1 0.2 3.4e-17 62.1 0.1 1.5 2 0 0 2 2 2 1 STAS domain STAS_2 PF13466.6 VDM91832.1 - 0.13 12.7 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 STAS domain TPR_8 PF13181.6 VDM91834.1 - 0.0023 18.0 0.0 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDM91834.1 - 0.003 17.5 0.1 0.071 13.3 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDM91834.1 - 0.017 14.9 0.0 0.1 12.4 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDM91834.1 - 0.041 14.3 0.0 5.7 7.5 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 VDM91835.1 - 6.4e-11 41.9 0.0 1.1e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 VDM91835.1 - 3.2e-06 26.8 0.0 5.1e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2 PF00096.26 VDM91835.1 - 0.036 14.5 0.9 12 6.5 0.0 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDM91835.1 - 0.12 13.3 0.6 7.5 7.7 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger TFIIA PF03153.13 VDM91836.1 - 6.3 6.7 16.0 8.4 6.3 16.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mon2_C PF16206.5 VDM91839.1 - 3.6e-67 227.2 4.4 5e-67 226.7 4.4 1.2 1 0 0 1 1 1 1 C-terminal region of Mon2 protein SAP25 PF15476.6 VDM91839.1 - 0.19 11.4 0.4 0.3 10.7 0.4 1.3 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP25 Ank_2 PF12796.7 VDM91840.1 - 3e-14 53.3 0.6 1.5e-11 44.7 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDM91840.1 - 1.9e-12 46.2 0.7 4.9e-07 29.6 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 VDM91840.1 - 6.4e-10 39.0 1.3 4.6e-07 30.0 0.3 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 VDM91840.1 - 1.2e-09 38.2 0.9 1.3e-06 28.6 0.2 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 VDM91840.1 - 1.3e-09 38.4 0.3 5.3e-07 30.1 0.1 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Meiotic_rec114 PF03525.14 VDM91840.1 - 0.04 12.9 0.1 0.057 12.4 0.1 1.2 1 0 0 1 1 1 0 Meiotic recombination protein rec114 Rad60-SLD_2 PF13881.6 VDM91845.1 - 3.8e-26 91.4 0.0 4.9e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 VDM91845.1 - 0.0074 16.0 0.0 0.018 14.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family RNase_T PF00929.24 VDM91847.1 - 1.9e-13 51.3 0.0 3.3e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 VDM91847.1 - 0.011 15.4 0.0 0.023 14.4 0.0 1.5 1 1 0 1 1 1 0 3'-5' exonuclease Oxysterol_BP PF01237.18 VDM91851.1 - 9.7e-11 41.1 2.2 1.3e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 Oxysterol-binding protein PH PF00169.29 VDM91851.1 - 2.9e-06 27.7 0.0 5.5e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 PH domain CLN3 PF02487.17 VDM91856.1 - 2e-117 392.6 17.7 2.7e-117 392.2 17.7 1.2 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 VDM91856.1 - 0.035 13.1 31.1 0.0071 15.3 9.1 2.8 1 1 1 2 2 2 0 Major Facilitator Superfamily NLBH PF05211.12 VDM91859.1 - 0.02 14.5 0.2 0.025 14.2 0.2 1.1 1 0 0 1 1 1 0 Neuraminyllactose-binding hemagglutinin precursor (NLBH) Coilin_N PF15862.5 VDM91859.1 - 0.15 11.9 1.3 0.15 11.8 0.2 1.6 2 0 0 2 2 2 0 Coilin N-terminus Pkinase PF00069.25 VDM91860.1 - 5e-17 62.1 0.3 1.6e-14 54.0 0.3 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM91860.1 - 2.3e-12 46.7 0.2 1.8e-10 40.6 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase OSR1_C PF12202.8 VDM91860.1 - 0.023 14.9 0.2 0.66 10.2 0.1 2.6 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain SAM_2 PF07647.17 VDM91863.1 - 0.081 13.1 0.1 0.38 10.9 0.0 2.2 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) PhnH PF05845.12 VDM91865.1 - 0.13 12.0 0.1 4.6 6.9 0.0 2.1 2 0 0 2 2 2 0 Bacterial phosphonate metabolism protein (PhnH) LRR_8 PF13855.6 VDM91871.1 - 4.2e-14 52.1 12.9 7.3e-07 28.9 6.5 3.6 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 VDM91871.1 - 4.7e-11 42.8 16.1 8.5e-05 22.8 0.2 4.9 2 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 VDM91871.1 - 3.8e-07 29.8 2.3 2.2e-06 27.3 1.9 2.0 1 1 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 VDM91871.1 - 0.0022 17.9 9.6 0.035 14.2 0.3 5.3 6 0 0 6 6 6 1 Leucine Rich repeat PI-TkoII_IV PF18714.1 VDM91871.1 - 0.051 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV LRR_1 PF00560.33 VDM91871.1 - 0.22 12.2 11.5 59 4.8 0.0 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat Patched PF02460.18 VDM91874.1 - 1.8e-245 816.9 18.2 1.1e-165 553.0 0.0 2.0 1 1 1 2 2 2 2 Patched family Sterol-sensing PF12349.8 VDM91874.1 - 1.6e-35 122.2 7.4 1.6e-35 122.2 7.4 2.8 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation DUF1687 PF07955.11 VDM91874.1 - 0.083 13.4 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1687) GP41 PF00517.17 VDM91874.1 - 0.77 9.6 4.0 12 5.7 0.2 2.7 2 0 0 2 2 2 0 Retroviral envelope protein TMEM151 PF14857.6 VDM91876.1 - 7.4e-120 400.7 6.4 9.9e-120 400.3 6.4 1.1 1 0 0 1 1 1 1 TMEM151 family 7tm_1 PF00001.21 VDM91878.1 - 7.7e-10 38.5 15.2 1e-06 28.3 1.8 2.5 1 1 1 2 2 2 2 7 transmembrane receptor (rhodopsin family) Pkinase_Tyr PF07714.17 VDM91879.1 - 1.4e-75 253.9 2.2 1.9e-75 253.5 1.3 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 VDM91879.1 - 5.9e-43 147.1 1.8 8.9e-43 146.5 1.8 1.2 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDM91879.1 - 4e-06 26.8 0.0 1.2e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 SH2 domain Pkinase_fungal PF17667.1 VDM91879.1 - 0.00091 18.1 0.7 0.064 12.0 0.0 2.3 2 0 0 2 2 2 2 Fungal protein kinase RIO1 PF01163.22 VDM91879.1 - 0.036 13.7 2.5 0.83 9.2 2.5 2.2 1 1 0 1 1 1 0 RIO1 family FOXP-CC PF16159.5 VDM91879.1 - 0.067 13.8 2.2 7.5 7.3 0.4 3.0 3 0 0 3 3 3 0 FOXP coiled-coil domain DUF4349 PF14257.6 VDM91881.1 - 0.0013 18.2 0.2 0.0084 15.6 0.1 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4349) ssDBP_DBD PF18361.1 VDM91881.1 - 0.028 14.6 0.7 0.15 12.2 0.0 2.4 2 1 1 3 3 3 0 Single stranded DNA-binding protein ss DNA binding domain Flp1_like PF16982.5 VDM91881.1 - 1 8.8 4.5 3.1 7.3 4.5 1.8 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain DUF4713 PF15831.5 VDM91881.1 - 6.2 7.3 11.2 14 6.2 11.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) SEA PF01390.20 VDM91883.1 - 0.0035 17.4 0.0 0.0051 16.9 0.0 1.3 1 0 0 1 1 1 1 SEA domain WD40 PF00400.32 VDM91886.1 - 9.8e-06 26.2 1.9 0.0047 17.7 0.0 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.32 VDM91887.1 - 0.00032 21.4 14.3 0.059 14.3 3.1 4.9 4 1 1 5 5 5 1 WD domain, G-beta repeat PQQ PF01011.21 VDM91887.1 - 0.0019 18.1 1.0 0.0067 16.3 0.1 2.4 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_3 PF13570.6 VDM91887.1 - 0.0019 18.6 0.9 0.53 10.8 0.0 3.0 3 0 0 3 3 3 2 PQQ-like domain GIIM PF08388.11 VDM91887.1 - 0.037 14.1 0.0 0.081 13.0 0.0 1.6 1 0 0 1 1 1 0 Group II intron, maturase-specific domain DPPIV_N PF00930.21 VDM91887.1 - 0.13 11.0 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cation_efflux PF01545.21 VDM91892.1 - 1e-28 100.4 14.7 1.3e-28 100.2 14.7 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 VDM91892.1 - 0.0033 17.5 0.0 0.0071 16.5 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter XK-related PF09815.9 VDM91892.1 - 0.025 13.7 4.6 0.076 12.1 4.6 1.7 1 1 0 1 1 1 0 XK-related protein MCU PF04678.13 VDM91892.1 - 0.062 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter PIG-P PF08510.12 VDM91892.1 - 1.7 8.5 5.3 0.5 10.3 0.1 2.2 2 0 0 2 2 2 0 PIG-P PHO4 PF01384.20 VDM91892.1 - 7.8 5.4 9.1 11 5.0 9.1 1.1 1 0 0 1 1 1 0 Phosphate transporter family Filamin PF00630.19 VDM91895.1 - 1.5e-15 57.8 0.4 1.1e-07 32.6 0.0 2.6 2 0 0 2 2 2 2 Filamin/ABP280 repeat RPN2_C PF18004.1 VDM91895.1 - 0.085 12.8 11.1 0.16 11.9 11.1 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Big_3_5 PF16640.5 VDM91895.1 - 0.15 12.3 0.6 1.1 9.5 0.8 2.2 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 3) DUF728 PF05304.12 VDM91895.1 - 0.26 11.2 3.8 0.45 10.4 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF728) Eapp_C PF10238.9 VDM91895.1 - 6.6 6.8 8.3 12 6.0 8.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Sec62 PF03839.16 VDM91895.1 - 8.4 5.8 10.0 18 4.7 10.0 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 Connexin PF00029.19 VDM91895.1 - 8.5 6.1 6.5 14 5.4 6.5 1.3 1 0 0 1 1 1 0 Connexin Filamin PF00630.19 VDM91896.1 - 1.8e-69 231.1 6.4 1.4e-12 48.3 0.1 9.1 8 1 0 8 8 8 8 Filamin/ABP280 repeat Big_3_5 PF16640.5 VDM91896.1 - 9.8e-05 22.5 0.0 6.7 7.0 0.0 4.3 4 0 0 4 4 4 2 Bacterial Ig-like domain (group 3) Big_6 PF17936.1 VDM91896.1 - 6.7 7.1 7.9 27 5.1 0.1 4.7 4 0 0 4 4 4 0 Bacterial Ig domain Velvet PF11754.8 VDM91898.1 - 0.075 13.0 7.3 0.094 12.6 7.3 1.2 1 0 0 1 1 1 0 Velvet factor TFIIA PF03153.13 VDM91898.1 - 2.9 7.8 25.5 4.4 7.2 25.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 VDM91898.1 - 5.4 5.1 21.8 6.3 4.9 21.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EF-hand_6 PF13405.6 VDM91900.1 - 0.0096 15.8 0.7 0.026 14.4 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain L27 PF02828.16 VDM91900.1 - 0.021 14.6 0.1 0.044 13.5 0.1 1.5 1 0 0 1 1 1 0 L27 domain EF-hand_7 PF13499.6 VDM91900.1 - 0.022 15.2 2.1 0.036 14.5 0.6 2.0 2 1 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 VDM91900.1 - 0.024 14.2 1.3 0.061 12.9 0.1 2.3 2 1 0 2 2 2 0 EF hand EF-hand_5 PF13202.6 VDM91900.1 - 0.037 13.5 1.2 0.15 11.6 0.3 2.5 1 1 1 2 2 2 0 EF hand SIX1_SD PF16878.5 VDM91900.1 - 0.046 14.2 0.2 0.25 11.9 0.0 2.1 2 1 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain DUF1759 PF03564.15 VDM91900.1 - 0.057 13.4 1.8 0.28 11.1 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) Sdh5 PF03937.16 VDM91900.1 - 0.18 11.8 1.6 1.5 8.8 0.6 2.2 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase FtsX_ECD PF18075.1 VDM91900.1 - 2.2 9.0 6.3 71 4.1 3.3 2.9 2 1 0 2 2 2 0 FtsX extracellular domain Suppressor_APC PF11414.8 VDM91901.1 - 1.3e-07 31.6 2.0 1.5e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 Adenomatous polyposis coli tumour suppressor protein DUF2461 PF09365.10 VDM91901.1 - 0.0052 16.8 0.2 0.0073 16.3 0.2 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) zf-RING_UBOX PF13445.6 VDM91903.1 - 0.0015 18.6 0.6 0.0042 17.1 0.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 VDM91903.1 - 0.0022 17.4 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger GyrB_insert PF18053.1 VDM91903.1 - 0.0093 15.9 0.1 0.025 14.4 0.1 1.7 1 0 0 1 1 1 1 DNA gyrase B subunit insert domain IMD PF08397.11 VDM91903.1 - 0.029 13.8 1.3 0.2 11.0 0.1 2.2 2 0 0 2 2 2 0 IRSp53/MIM homology domain ELYS PF13934.6 VDM91903.1 - 0.076 13.0 0.2 0.27 11.2 0.1 1.9 2 0 0 2 2 2 0 Nuclear pore complex assembly HSA PF07529.13 VDM91903.1 - 0.079 13.3 0.1 0.29 11.5 0.1 1.9 2 0 0 2 2 2 0 HSA TPR_1 PF00515.28 VDM91905.1 - 0.00011 21.8 0.1 0.031 14.1 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 VDM91905.1 - 0.00033 20.9 1.4 0.05 13.9 0.9 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 VDM91905.1 - 0.0014 18.6 0.5 0.79 10.0 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 VDM91905.1 - 0.0072 16.5 0.7 2.3 8.6 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 VDM91905.1 - 0.0079 16.2 0.8 25 5.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 VDM91905.1 - 0.035 14.5 0.2 0.42 11.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 VDM91905.1 - 0.05 13.3 0.5 0.36 10.5 0.0 2.7 4 1 0 4 4 4 0 TPR repeat ChAPs PF09295.10 VDM91905.1 - 0.11 11.5 0.4 0.38 9.7 0.2 1.7 1 1 1 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) FATC PF02260.20 VDM91913.1 - 2.2e-13 49.7 0.5 3.7e-13 49.0 0.5 1.4 1 0 0 1 1 1 1 FATC domain DASH_Dam1 PF08653.10 VDM91913.1 - 0.054 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 DASH complex subunit Dam1 TRAP-delta PF05404.12 VDM91917.1 - 0.017 14.7 0.1 0.017 14.7 0.1 1.8 2 0 0 2 2 2 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) DUF3069 PF11269.8 VDM91917.1 - 0.089 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) MRAP PF15183.6 VDM91917.1 - 0.099 12.6 0.3 0.25 11.3 0.0 1.7 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family MyTH4 PF00784.17 VDM91918.1 - 3.3e-20 72.6 0.0 9e-20 71.2 0.0 1.8 1 0 0 1 1 1 1 MyTH4 domain WW PF00397.26 VDM91918.1 - 2.2e-09 37.2 7.7 1e-05 25.5 4.5 2.8 2 0 0 2 2 2 2 WW domain 7tm_1 PF00001.21 VDM91919.1 - 5e-14 52.3 0.0 5e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) TAS2R PF05296.13 VDM91919.1 - 0.0092 15.1 0.2 0.014 14.5 0.2 1.1 1 0 0 1 1 1 1 Taste receptor protein (TAS2R) Tetraspanin PF00335.20 VDM91919.1 - 0.023 14.4 0.1 0.036 13.8 0.1 1.3 1 0 0 1 1 1 0 Tetraspanin family MyTH4 PF00784.17 VDM91920.1 - 3.3e-20 72.6 0.0 9e-20 71.2 0.0 1.8 1 0 0 1 1 1 1 MyTH4 domain WW PF00397.26 VDM91920.1 - 2.2e-09 37.2 7.7 1e-05 25.5 4.5 2.8 2 0 0 2 2 2 2 WW domain CAC1F_C PF16885.5 VDM91924.1 - 1.5 8.4 12.0 2.4 7.8 12.0 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term SRF-TF PF00319.18 VDM91926.1 - 3.5e-20 71.2 0.1 5.6e-20 70.6 0.1 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SKG6 PF08693.10 VDM91927.1 - 0.85 9.1 3.5 1.5 8.3 3.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain PAP2 PF01569.21 VDM91929.1 - 1.4e-22 80.0 6.2 3.2e-22 78.8 6.2 1.5 1 0 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 VDM91929.1 - 0.021 15.4 2.6 0.021 15.4 2.6 2.7 2 1 0 2 2 2 0 PAP2 superfamily C-terminal PAP2_3 PF14378.6 VDM91929.1 - 3.3 7.4 9.3 0.83 9.3 3.4 2.7 2 1 0 2 2 2 0 PAP2 superfamily RRM_1 PF00076.22 VDM91930.1 - 2.1e-17 62.7 0.0 3.6e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 VDM91930.1 - 0.0014 18.4 0.0 0.0026 17.6 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 VDM91930.1 - 0.011 15.3 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 VDM91930.1 - 1.7 8.5 7.9 2 8.3 7.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Guanylate_cyc PF00211.20 VDM91932.1 - 4.3e-56 189.4 2.3 1.7e-54 184.2 0.6 3.3 2 1 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_Tyr PF07714.17 VDM91932.1 - 1.3e-34 119.6 0.0 2.4e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDM91932.1 - 4.2e-32 111.6 0.1 7.7e-32 110.7 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain HNOBA PF07701.14 VDM91932.1 - 0.002 17.6 1.0 0.0038 16.7 1.0 1.4 1 0 0 1 1 1 1 Heme NO binding associated DUF3958 PF13125.6 VDM91932.1 - 0.11 12.8 1.1 0.26 11.5 1.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) Homeobox_KN PF05920.11 VDM91934.1 - 2.5e-09 36.9 0.1 5.1e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 VDM91934.1 - 4e-08 33.0 1.3 7e-08 32.2 1.3 1.4 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 VDM91934.1 - 0.003 17.0 0.1 0.0051 16.3 0.1 1.3 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez Dna2 PF08696.11 VDM91934.1 - 0.043 13.6 0.1 0.051 13.4 0.1 1.1 1 0 0 1 1 1 0 DNA replication factor Dna2 MRP-S32 PF10210.9 VDM91934.1 - 0.23 12.1 1.8 0.38 11.3 1.8 1.5 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 HemY_N PF07219.13 VDM91934.1 - 7.1 6.9 6.0 21 5.4 0.1 2.1 1 1 1 2 2 2 0 HemY protein N-terminus CPBP PF02517.16 VDM91940.1 - 7.7e-15 55.0 0.6 7.7e-15 55.0 0.6 1.4 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease Bestrophin PF01062.21 VDM91941.1 - 8e-74 248.7 1.4 9.1e-74 248.5 1.4 1.0 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Collagen PF01391.18 VDM91948.1 - 9.6e-24 82.9 94.4 9.4e-09 34.9 30.7 4.3 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDM91948.1 - 3.9e-08 33.2 0.4 7.4e-08 32.3 0.4 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain DUF4377 PF14302.6 VDM91949.1 - 0.16 12.0 0.0 0.19 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4377) Thyroglobulin_1 PF00086.18 VDM91953.1 - 9.8e-18 63.6 1.6 2.7e-17 62.2 1.6 1.8 1 0 0 1 1 1 1 Thyroglobulin type-1 repeat SPARC_Ca_bdg PF10591.9 VDM91953.1 - 4.1e-12 46.4 0.8 8.6e-12 45.4 0.8 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Kazal_2 PF07648.15 VDM91953.1 - 6.5e-06 26.2 3.0 6.5e-06 26.2 3.0 2.5 2 1 0 2 2 2 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 VDM91953.1 - 3.4e-05 23.8 7.6 6.8e-05 22.8 4.1 2.6 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain EF-hand_6 PF13405.6 VDM91953.1 - 7.4e-05 22.4 0.1 0.57 10.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 VDM91953.1 - 8.7e-05 21.8 0.1 0.48 10.1 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 VDM91953.1 - 9.2e-05 22.8 0.3 0.00018 21.9 0.3 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 VDM91953.1 - 0.0019 17.6 0.6 0.12 11.9 0.0 2.4 2 0 0 2 2 2 1 EF hand 2-Hacid_dh_C PF02826.19 VDM91955.1 - 2.9e-49 166.8 0.0 5.3e-49 166.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 VDM91955.1 - 0.0028 17.8 0.0 0.0083 16.3 0.0 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 VDM91955.1 - 0.093 12.3 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPGT PF00201.18 VDM91957.1 - 7e-06 25.1 0.0 7.4e-06 25.0 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase zf-H2C2_2 PF13465.6 VDM91960.1 - 1.4e-07 31.6 19.1 1.1e-05 25.7 5.7 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 VDM91960.1 - 1.3e-06 28.5 21.2 0.00029 21.1 7.1 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDM91960.1 - 3.4e-06 27.4 17.2 5.7e-05 23.6 4.5 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 VDM91960.1 - 0.00033 20.6 2.7 0.00033 20.6 2.7 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 VDM91960.1 - 1.9 9.0 8.0 2.5 8.6 1.8 2.4 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDM91960.1 - 3.3 8.1 10.4 0.49 10.8 1.6 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding TPR_2 PF07719.17 VDM91962.1 - 5.4e-05 23.0 0.9 1.3 9.3 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat YfiO PF13525.6 VDM91962.1 - 0.0054 16.5 3.0 0.81 9.4 0.3 3.1 3 0 0 3 3 3 1 Outer membrane lipoprotein TFIIF_beta PF02270.15 VDM91962.1 - 0.021 14.9 0.6 0.072 13.2 0.3 2.1 2 0 0 2 2 2 0 TFIIF, beta subunit HTH domain TPR_14 PF13428.6 VDM91962.1 - 0.025 15.4 0.0 1.5 9.8 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Pentaxin PF00354.17 VDM91962.1 - 0.065 12.9 0.5 0.79 9.4 0.0 2.1 2 0 0 2 2 2 0 Pentaxin family zf-C2H2 PF00096.26 VDM91966.1 - 1.4e-13 50.4 31.1 0.00055 20.3 2.1 5.8 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 VDM91966.1 - 1.2e-08 34.6 15.4 9.7e-06 25.2 0.8 3.8 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 VDM91966.1 - 1.9e-08 34.5 29.6 0.15 13.0 1.0 5.9 5 0 0 5 5 5 4 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 VDM91966.1 - 1.3e-05 24.7 1.9 0.041 13.5 0.0 3.7 3 0 0 3 3 3 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-met PF12874.7 VDM91966.1 - 2.2e-05 24.7 26.7 0.55 10.7 3.5 6.1 5 0 0 5 5 5 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDM91966.1 - 0.00032 20.9 23.8 0.7 10.2 3.4 5.8 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 VDM91966.1 - 0.0045 17.3 20.9 0.066 13.5 3.2 4.9 3 2 2 5 5 5 2 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 VDM91966.1 - 0.0069 16.4 13.9 0.023 14.7 0.0 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDM91966.1 - 0.017 15.6 1.4 0.017 15.6 1.4 4.1 5 0 0 5 5 5 0 Zinc-finger double domain POTRA_TamA_1 PF17243.2 VDM91966.1 - 0.087 12.9 0.4 0.31 11.1 0.4 2.0 1 0 0 1 1 1 0 POTRA domain TamA domain 1 zinc_ribbon_15 PF17032.5 VDM91966.1 - 1.1 10.1 8.9 6.2 7.6 0.5 3.4 3 0 0 3 3 3 0 zinc-ribbon family zf-C2H2_7 PF15269.6 VDM91966.1 - 1.7 8.8 6.9 56 3.9 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger OrsD PF12013.8 VDM91966.1 - 2.1 8.8 19.1 0.11 13.0 0.4 5.1 4 2 0 5 5 5 0 Orsellinic acid/F9775 biosynthesis cluster protein D AKAP95 PF04988.12 VDM91966.1 - 9.8 6.4 17.9 2.8 8.1 0.4 4.6 5 0 0 5 5 5 0 A-kinase anchoring protein 95 (AKAP95) I-set PF07679.16 VDM91969.1 - 3.9e-18 65.3 0.0 7.4e-17 61.2 0.0 2.3 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDM91969.1 - 5.8e-17 62.1 0.0 3.9e-14 53.0 0.0 2.4 2 0 0 2 2 2 2 Immunoglobulin domain Ig_2 PF13895.6 VDM91969.1 - 1.4e-16 60.6 0.0 6.3e-13 48.9 0.0 2.5 2 1 0 2 2 2 2 Immunoglobulin domain V-set PF07686.17 VDM91969.1 - 6.2e-10 39.2 0.0 0.0077 16.4 0.0 3.5 2 1 1 3 3 3 2 Immunoglobulin V-set domain ig PF00047.25 VDM91969.1 - 3e-09 36.9 0.0 7.7e-07 29.2 0.0 2.8 2 1 0 2 2 2 1 Immunoglobulin domain Ig_5 PF16681.5 VDM91969.1 - 0.00013 22.3 0.0 0.00039 20.8 0.0 1.8 2 0 0 2 2 1 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain C2-set_2 PF08205.12 VDM91969.1 - 0.00019 21.4 0.0 0.0027 17.8 0.0 2.4 1 1 1 2 2 2 1 CD80-like C2-set immunoglobulin domain Ig_4 PF16680.5 VDM91969.1 - 0.00043 20.5 0.1 0.0053 17.0 0.0 2.6 3 0 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain TRI12 PF06609.13 VDM91969.1 - 0.0025 16.3 0.3 0.0035 15.8 0.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Izumo-Ig PF16706.5 VDM91969.1 - 0.0059 16.6 0.0 0.5 10.5 0.0 2.8 3 0 0 3 3 3 1 Izumo-like Immunoglobulin domain DUF2207 PF09972.9 VDM91969.1 - 0.01 14.6 0.0 0.013 14.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) C1-set PF07654.15 VDM91969.1 - 0.014 15.8 0.1 0.05 14.0 0.0 2.0 1 1 0 1 1 1 0 Immunoglobulin C1-set domain Comm PF15957.5 VDM91969.1 - 0.014 15.7 0.5 0.026 14.9 0.2 1.6 2 0 0 2 2 1 0 Commissureless Ig_6 PF18452.1 VDM91969.1 - 0.068 12.7 0.0 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 Immunoglobulin domain LRR19-TM PF15176.6 VDM91969.1 - 0.13 12.3 0.1 0.22 11.6 0.1 1.3 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain T2SSF PF00482.23 VDM91969.1 - 0.23 11.4 0.4 0.4 10.6 0.4 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF2228 PF10228.9 VDM91972.1 - 1.6e-59 201.7 0.0 2.1e-59 201.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2228) CagX PF03524.15 VDM91972.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Conjugal transfer protein DB PF01682.19 VDM91973.1 - 5.1e-23 81.2 29.0 2.3e-12 47.0 11.0 2.4 2 0 0 2 2 2 2 DB module fn3 PF00041.21 VDM91973.1 - 2.7e-12 46.9 0.5 1.8e-11 44.2 0.1 2.5 3 0 0 3 3 3 1 Fibronectin type III domain Ig_3 PF13927.6 VDM91973.1 - 3.9e-07 30.6 0.0 1.2e-06 29.0 0.0 1.9 1 0 0 1 1 1 1 Immunoglobulin domain ig PF00047.25 VDM91973.1 - 1.3e-06 28.5 0.1 3.5e-06 27.1 0.1 1.7 1 0 0 1 1 1 1 Immunoglobulin domain I-set PF07679.16 VDM91973.1 - 3.2e-05 23.9 0.1 0.00024 21.1 0.0 2.5 3 0 0 3 3 3 1 Immunoglobulin I-set domain V-set PF07686.17 VDM91973.1 - 0.00053 20.1 0.1 0.0014 18.8 0.1 1.6 1 0 0 1 1 1 1 Immunoglobulin V-set domain fn3_2 PF16893.5 VDM91973.1 - 0.00085 19.4 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain SusE PF14292.6 VDM91973.1 - 0.033 14.4 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 SusE outer membrane protein Pur_ac_phosph_N PF16656.5 VDM91973.1 - 0.28 11.8 2.3 0.49 11.0 0.5 2.3 1 1 1 2 2 2 0 Purple acid Phosphatase, N-terminal domain DNApol3-delta_C PF09115.10 VDM91976.1 - 0.073 13.6 1.5 0.099 13.2 0.4 1.8 2 1 0 2 2 2 0 DNA polymerase III, delta subunit, C terminal Neur_chan_LBD PF02931.23 VDM91978.1 - 8.3e-22 77.7 0.1 1.1e-21 77.3 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDM91978.1 - 3.2e-17 63.4 0.3 4.1e-17 63.0 0.3 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF1759 PF03564.15 VDM91980.1 - 0.055 13.4 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) STT3_PglB_C PF18527.1 VDM91981.1 - 0.062 13.4 0.4 0.31 11.2 0.4 2.1 1 1 0 1 1 1 0 STT3/PglB C-terminal beta-barrel domain TPR_12 PF13424.6 VDM91985.1 - 1.4e-18 66.9 2.6 2e-10 40.8 0.1 5.2 4 1 3 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 VDM91985.1 - 1.4e-13 50.3 0.4 0.00016 21.4 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 VDM91985.1 - 7.7e-07 28.8 4.0 0.43 10.9 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 VDM91985.1 - 7.2e-06 25.7 0.7 0.39 10.8 0.0 4.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 VDM91985.1 - 7.2e-05 22.6 10.5 0.23 11.6 0.0 5.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 VDM91985.1 - 0.00025 21.6 0.0 0.57 11.1 0.0 4.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 VDM91985.1 - 0.00058 19.6 9.4 1.1 9.2 0.0 5.1 6 0 0 6 6 6 3 Tetratricopeptide repeat adh_short PF00106.25 VDM91986.1 - 1.5e-26 93.1 0.1 2e-26 92.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDM91986.1 - 1.6e-18 67.1 0.0 2.1e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDM91986.1 - 3.9e-05 23.6 0.0 6.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Collagen PF01391.18 VDM91987.1 - 8.4e-25 86.3 89.9 1.2e-09 37.8 27.5 4.2 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Col_cuticle_N PF01484.17 VDM91987.1 - 3.4e-07 30.2 0.5 5.2e-07 29.6 0.5 1.3 1 0 0 1 1 1 1 Nematode cuticle collagen N-terminal domain DEAD PF00270.29 VDM91989.1 - 1.5e-18 67.2 0.1 1.6e-17 63.9 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 VDM91989.1 - 1.9e-15 57.1 0.0 2e-11 44.2 0.0 3.4 3 0 0 3 3 3 2 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 VDM91989.1 - 2.9e-10 40.7 2.9 2.9e-10 40.7 2.9 3.4 3 0 0 3 3 3 1 RecQ zinc-binding ResIII PF04851.15 VDM91989.1 - 3.2e-05 24.0 0.1 3.2e-05 24.0 0.1 2.3 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2027 PF09640.10 VDM91989.1 - 0.012 15.2 0.0 0.033 13.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2027) MBT PF02820.18 VDM91995.1 - 8.4e-35 119.0 0.1 3.4e-18 65.7 0.0 2.5 2 0 0 2 2 2 2 mbt repeat SLED PF12140.8 VDM91995.1 - 9.5e-29 100.2 0.4 2.6e-28 98.8 0.1 2.0 2 0 0 2 2 2 1 SLED domain SAM_1 PF00536.30 VDM91995.1 - 8.5e-05 22.9 0.1 0.00023 21.5 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) FERM_M PF00373.18 VDM91999.1 - 1.9e-21 76.6 0.2 3e-21 76.0 0.2 1.3 1 0 0 1 1 1 1 FERM central domain FERM_C PF09380.10 VDM91999.1 - 1.9e-20 73.0 0.1 8.1e-20 71.0 0.0 2.1 3 0 0 3 3 3 1 FERM C-terminal PH-like domain FERM_N PF09379.10 VDM91999.1 - 5.6e-18 64.6 1.0 5.8e-17 61.4 0.2 2.5 3 0 0 3 3 3 1 FERM N-terminal domain bPH_6 PF10756.9 VDM91999.1 - 0.033 14.3 0.0 0.084 13.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial PH domain preATP-grasp_3 PF18301.1 VDM91999.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 pre ATP-grasp 3 domain FA PF08736.11 VDM91999.1 - 1.2 9.3 3.5 2.1 8.5 3.5 1.4 1 0 0 1 1 1 0 FERM adjacent (FA) PNISR PF15996.5 VDM92010.1 - 2.3e-25 90.1 20.8 2.3e-25 90.1 20.8 3.9 1 1 2 3 3 3 1 Arginine/serine-rich protein PNISR RXT2_N PF08595.11 VDM92016.1 - 0.46 10.5 3.9 0.47 10.5 3.9 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2457 PF10446.9 VDM92016.1 - 0.62 9.2 11.4 0.59 9.2 11.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 VDM92016.1 - 2.3 6.2 8.8 2.3 6.2 8.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 VDM92016.1 - 5.8 6.1 12.1 6.2 6.0 12.1 1.0 1 0 0 1 1 1 0 NOA36 protein ABC1 PF03109.16 VDM92017.1 - 6.5e-35 119.9 0.0 1.1e-34 119.2 0.0 1.4 1 0 0 1 1 1 1 ABC1 family CooT PF10133.9 VDM92018.1 - 0.14 12.5 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 CO dehydrogenase accessory protein CooT zf-BED PF02892.15 VDM92019.1 - 4.7e-10 39.3 1.4 4.7e-10 39.3 1.4 2.3 2 0 0 2 2 2 1 BED zinc finger Collagen PF01391.18 VDM92021.1 - 2.2e-05 24.1 6.7 3.1e-05 23.6 6.7 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Calcipressin PF04847.12 VDM92022.1 - 1.3e-30 106.6 0.6 1.6e-30 106.3 0.6 1.1 1 0 0 1 1 1 1 Calcipressin UAA PF08449.11 VDM92024.1 - 1.3e-23 83.7 8.5 1.6e-23 83.3 8.5 1.0 1 0 0 1 1 1 1 UAA transporter family YwiC PF14256.6 VDM92024.1 - 0.074 13.4 2.9 0.1 12.9 2.8 1.2 1 1 0 1 1 1 0 YwiC-like protein EamA PF00892.20 VDM92024.1 - 0.1 12.7 13.9 0.12 12.5 13.9 1.1 1 0 0 1 1 1 0 EamA-like transporter family DUF2070 PF09843.9 VDM92024.1 - 1.1 7.5 6.8 1.2 7.3 6.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Ephrin_rec_like PF07699.13 VDM92026.1 - 2e-06 27.4 53.0 0.0016 18.1 4.9 8.0 4 3 4 8 8 8 6 Putative ephrin-receptor like LST1 PF05083.13 VDM92026.1 - 0.052 13.8 0.0 3.6 7.9 0.0 2.8 2 0 0 2 2 2 0 LST-1 protein NCD3G PF07562.14 VDM92026.1 - 0.094 12.7 52.6 0.072 13.1 1.7 8.7 8 1 0 8 8 8 0 Nine Cysteines Domain of family 3 GPCR DUF4446 PF14584.6 VDM92026.1 - 0.18 11.8 0.1 0.71 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) C6 PF01681.17 VDM92028.1 - 2e-08 34.6 0.1 9.8e-08 32.4 0.0 2.1 2 0 0 2 2 2 1 C6 domain TSP_1 PF00090.19 VDM92028.1 - 9.9e-07 28.9 6.9 9.9e-07 28.9 6.9 2.0 2 0 0 2 2 2 1 Thrombospondin type 1 domain Biopterin_H PF00351.21 VDM92031.1 - 2.6e-129 431.0 0.1 3.9e-129 430.4 0.1 1.2 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase Histone PF00125.24 VDM92032.1 - 4.9e-17 62.5 0.3 6.5e-17 62.1 0.3 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 VDM92032.1 - 2.9e-14 52.5 0.1 6.8e-14 51.3 0.1 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 VDM92032.1 - 9.6e-06 25.8 0.0 1.3e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-18kDa PF02269.16 VDM92032.1 - 0.016 15.3 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 VDM92033.1 - 1.2e-17 64.5 7.4 1.5e-17 64.2 7.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 VDM92033.1 - 2.7e-05 24.4 0.1 5.6e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone NCKAP5 PF15246.6 VDM92033.1 - 0.00095 18.9 5.3 0.0011 18.6 5.3 1.1 1 0 0 1 1 1 1 Nck-associated protein 5, Peripheral clock protein SR-25 PF10500.9 VDM92033.1 - 0.0033 17.1 15.5 0.0043 16.7 15.5 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein HAUS-augmin3 PF14932.6 VDM92033.1 - 0.0047 16.5 0.2 0.0049 16.5 0.2 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 ORC6 PF05460.13 VDM92033.1 - 0.013 14.8 2.4 0.013 14.8 2.4 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Arm_APC_u3 PF16629.5 VDM92033.1 - 0.014 15.0 4.0 0.017 14.7 4.0 1.1 1 0 0 1 1 1 0 Armadillo-associated region on APC Connexin PF00029.19 VDM92033.1 - 0.49 10.1 2.7 0.6 9.8 2.7 1.1 1 0 0 1 1 1 0 Connexin Dsh_C PF12316.8 VDM92033.1 - 0.73 10.2 7.1 0.84 10.0 7.1 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF3915 PF13054.6 VDM92033.1 - 1.1 9.3 4.9 5.3 7.0 4.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) DUF5427 PF10310.9 VDM92033.1 - 3.7 6.4 8.5 4.5 6.1 8.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Axin_b-cat_bind PF08833.10 VDM92033.1 - 9.1 6.5 8.1 27 5.0 0.0 3.0 2 1 0 2 2 2 0 Axin beta-catenin binding domain fn3 PF00041.21 VDM92035.1 - 1.4e-12 47.8 0.0 5.5e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 VDM92035.1 - 0.089 13.4 0.0 2.8 8.5 0.0 2.3 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain SUR7 PF06687.12 VDM92035.1 - 0.1 12.2 0.3 0.26 10.9 0.4 1.5 2 0 0 2 2 2 0 SUR7/PalI family Y_phosphatase PF00102.27 VDM92040.1 - 4.1e-68 229.5 0.0 4.9e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 VDM92040.1 - 0.00037 20.5 0.0 0.00067 19.7 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 VDM92040.1 - 0.0014 18.5 0.1 0.0041 16.9 0.1 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 VDM92040.1 - 0.03 13.9 0.0 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 VDM92040.1 - 0.079 13.1 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Ski_Sno PF02437.17 VDM92042.1 - 7.1e-29 99.7 0.2 1.5e-28 98.7 0.1 1.6 2 0 0 2 2 2 1 SKI/SNO/DAC family c-SKI_SMAD_bind PF08782.10 VDM92042.1 - 3.3e-22 78.5 0.8 5.5e-22 77.8 0.8 1.3 1 0 0 1 1 1 1 c-SKI Smad4 binding domain DUF1772 PF08592.11 VDM92043.1 - 0.0055 17.0 0.4 0.0063 16.8 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) MAP17 PF15807.5 VDM92043.1 - 0.011 16.0 0.4 0.013 15.7 0.4 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 OppC_N PF12911.7 VDM92043.1 - 0.094 12.7 1.9 0.095 12.7 0.1 1.8 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MscS_TM PF12794.7 VDM92043.1 - 0.8 8.5 4.8 0.29 9.9 1.7 1.7 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Pox_P21 PF05313.12 VDM92043.1 - 8.6 5.9 11.3 12 5.5 11.3 1.1 1 0 0 1 1 1 0 Poxvirus P21 membrane protein HemY_N PF07219.13 VDM92043.1 - 9.5 6.5 7.0 16 5.8 7.0 1.4 1 0 0 1 1 1 0 HemY protein N-terminus Pkinase PF00069.25 VDM92046.1 - 5.4e-50 170.2 0.0 7.8e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM92046.1 - 3.1e-25 88.9 0.0 4.4e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDM92046.1 - 6.7e-07 28.9 0.0 1.1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 VDM92046.1 - 2e-05 23.5 0.0 3.6e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Carn_acyltransf PF00755.20 VDM92049.1 - 3.9e-74 250.3 0.0 4.8e-74 250.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Carn_acyltransf PF00755.20 VDM92050.1 - 1.4e-68 232.0 0.5 1.6e-68 231.8 0.5 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase YchF-GTPase_C PF06071.13 VDM92050.1 - 0.097 12.9 0.0 0.34 11.1 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF933) DUF5110 PF17137.4 VDM92051.1 - 0.00071 19.8 0.3 0.00071 19.8 0.3 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF5110) DUF2286 PF10051.9 VDM92051.1 - 0.033 13.9 0.0 0.044 13.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2286) MetW PF07021.12 VDM92051.1 - 0.13 11.8 0.0 0.15 11.6 0.0 1.0 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DEK_C PF08766.11 VDM92058.1 - 9.6e-10 38.2 0.1 1.7e-09 37.4 0.1 1.5 1 0 0 1 1 1 1 DEK C terminal domain DUF5075 PF16825.5 VDM92058.1 - 0.011 15.4 0.2 0.017 14.8 0.2 1.2 1 0 0 1 1 1 0 IGP family C-type lectin domain Fusion_F0 PF13044.6 VDM92058.1 - 0.049 12.3 0.1 0.071 11.7 0.1 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0, Isavirus UBX PF00789.20 VDM92060.1 - 1.6e-17 63.4 0.0 3.9e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA PF00627.31 VDM92060.1 - 2.1e-07 30.7 0.0 4.8e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain CCDC71L PF15374.6 VDM92060.1 - 0.25 10.6 16.7 0.32 10.2 16.7 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DUF2175 PF09943.9 VDM92060.1 - 3.6 7.9 16.7 0.44 10.9 9.0 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) CDC45 PF02724.14 VDM92060.1 - 6.8 4.8 17.5 9.6 4.4 17.5 1.1 1 0 0 1 1 1 0 CDC45-like protein uDENN PF03456.18 VDM92062.1 - 0.01 16.5 0.0 0.017 15.9 0.0 1.3 1 0 0 1 1 1 0 uDENN domain uDENN PF03456.18 VDM92063.1 - 0.0091 16.7 0.0 0.023 15.5 0.0 1.7 1 0 0 1 1 1 1 uDENN domain CUB PF00431.20 VDM92064.1 - 3.6e-34 117.4 0.1 5.2e-24 84.7 0.0 2.5 2 0 0 2 2 2 2 CUB domain Lectin_C PF00059.21 VDM92064.1 - 6.6e-10 39.7 1.2 2.4e-09 37.9 1.2 2.0 1 0 0 1 1 1 1 Lectin C-type domain Ldl_recept_a PF00057.18 VDM92064.1 - 1.6e-08 34.6 11.3 3.2e-08 33.7 11.3 1.5 1 0 0 1 1 1 1 Low-density lipoprotein receptor domain class A CUB_2 PF02408.20 VDM92064.1 - 0.018 14.8 1.5 5.8 6.7 0.2 2.8 1 1 1 2 2 2 0 CUB-like domain DUF1422 PF07226.11 VDM92064.1 - 0.19 11.7 2.6 0.13 12.3 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) PDEase_I PF00233.19 VDM92068.1 - 3.7e-74 249.4 12.8 6.7e-60 202.8 3.8 2.2 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase UBA_e1_thiolCys PF10585.9 VDM92068.1 - 0.012 15.5 0.5 0.021 14.8 0.5 1.3 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site Nrap_D2 PF17403.2 VDM92068.1 - 0.037 13.8 0.2 0.072 12.8 0.2 1.4 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Opiods_neuropep PF01160.18 VDM92068.1 - 0.085 13.0 0.7 0.24 11.5 0.7 1.8 1 0 0 1 1 1 0 Vertebrate endogenous opioids neuropeptide CH PF00307.31 VDM92073.1 - 6.3e-05 23.1 0.0 0.00015 21.9 0.0 1.7 1 1 0 1 1 1 1 Calponin homology (CH) domain USP19_linker PF16602.5 VDM92073.1 - 0.054 14.1 3.7 0.49 10.9 0.3 2.8 2 1 1 3 3 3 0 Linker region of USP19 deubiquitinase TED_complement PF07678.14 VDM92079.1 - 8.3e-93 310.8 3.8 3.1e-47 161.1 0.1 2.2 2 0 0 2 2 2 2 A-macroglobulin TED domain A2M_recep PF07677.14 VDM92079.1 - 0.00029 21.5 0.1 0.0011 19.6 0.0 2.0 2 0 0 2 2 2 1 A-macroglobulin receptor binding domain A2M PF00207.22 VDM92080.1 - 4.9e-14 51.9 0.0 7.2e-14 51.4 0.0 1.2 1 0 0 1 1 1 1 Alpha-2-macroglobulin family Spy1 PF11357.8 VDM92081.1 - 0.12 12.7 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Cell cycle regulatory protein TMEM117 PF15113.6 VDM92084.1 - 0.0022 17.0 0.1 0.0041 16.1 0.1 1.4 1 0 0 1 1 1 1 TMEM117 protein family TTR-52 PF01060.23 VDM92085.1 - 2.9e-29 101.6 0.1 4.3e-29 101.0 0.1 1.3 1 0 0 1 1 1 1 Transthyretin-like family bMG3 PF11974.8 VDM92085.1 - 0.021 14.8 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain DKCLD PF08068.12 VDM92085.1 - 0.083 13.0 0.2 0.18 11.9 0.1 1.6 2 0 0 2 2 2 0 DKCLD (NUC011) domain Ribosomal_L50 PF10501.9 VDM92085.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal subunit 39S An_peroxidase PF03098.15 VDM92089.1 - 6e-163 543.2 0.0 6.8e-163 543.0 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase MIP PF00230.20 VDM92091.1 - 0.014 15.1 1.1 0.017 14.9 1.1 1.1 1 0 0 1 1 1 0 Major intrinsic protein FA_desaturase PF00487.24 VDM92092.1 - 2.4e-36 125.9 15.7 3.2e-36 125.5 15.7 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Peptidase_A22B PF04258.13 VDM92094.1 - 4.1e-22 79.0 6.5 6.5e-22 78.4 6.5 1.2 1 0 0 1 1 1 1 Signal peptide peptidase C1_1 PF00130.22 VDM92096.1 - 1.7e-12 47.0 15.2 2.2e-12 46.7 15.2 1.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 VDM92096.1 - 0.0035 17.4 7.1 0.0048 17.0 7.1 1.3 1 0 0 1 1 1 1 KIAA1045 RING finger C1_2 PF03107.16 VDM92096.1 - 0.097 13.0 10.5 0.13 12.6 10.5 1.3 1 0 0 1 1 1 0 C1 domain PDZ_2 PF13180.6 VDM92097.1 - 6.2e-11 42.5 0.3 0.00017 21.9 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDM92097.1 - 5e-08 32.7 0.0 0.006 16.4 0.0 2.3 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 VDM92097.1 - 6.9e-07 29.2 0.4 0.00051 19.9 0.0 2.3 2 0 0 2 2 2 2 Tricorn protease PDZ domain PDZ PF00595.24 VDM92097.1 - 5.7e-06 26.6 0.4 0.013 15.9 0.2 2.4 2 0 0 2 2 2 2 PDZ domain Peptidase_M13 PF01431.21 VDM92106.1 - 8.2e-61 205.2 0.0 1.5e-59 201.1 0.0 2.3 2 0 0 2 2 2 1 Peptidase family M13 Peptidase_M13_N PF05649.13 VDM92106.1 - 6e-55 187.5 0.0 9.7e-55 186.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Acyltransferase PF01553.21 VDM92112.1 - 1.4e-21 76.6 0.0 2.1e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 VDM92112.1 - 2.2e-09 37.3 0.0 5.4e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus TRPM_tetra PF16519.5 VDM92114.1 - 4.2e-05 23.6 3.0 9.8e-05 22.4 3.0 1.6 1 0 0 1 1 1 1 Tetramerisation domain of TRPM Ion_trans PF00520.31 VDM92114.1 - 0.0094 15.2 1.4 0.022 14.0 1.4 1.7 1 1 0 1 1 1 1 Ion transport protein DUF3153 PF11353.8 VDM92114.1 - 1.4 8.5 3.7 9.3 5.8 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3153) Kelch_5 PF13854.6 VDM92117.1 - 2.8e-10 39.9 1.1 0.0023 17.9 0.0 3.6 3 0 0 3 3 3 3 Kelch motif Laminin_EGF PF00053.24 VDM92117.1 - 5.9e-08 32.7 39.3 3e-05 24.1 15.6 6.0 6 1 0 6 6 6 2 Laminin EGF domain Kelch_2 PF07646.15 VDM92117.1 - 1.4e-07 31.2 6.1 0.094 12.7 0.1 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 VDM92117.1 - 7.3e-07 28.7 0.2 0.0096 15.5 0.0 3.1 2 0 0 2 2 2 2 Kelch motif PSI_integrin PF17205.3 VDM92117.1 - 2.7e-06 27.0 3.5 2.7e-06 27.0 3.5 6.5 6 0 0 6 6 6 1 Integrin plexin domain PSI PF01437.25 VDM92117.1 - 2.4e-05 24.8 32.8 0.00047 20.6 13.1 6.9 6 2 1 7 7 7 3 Plexin repeat Kelch_4 PF13418.6 VDM92117.1 - 0.0017 18.3 0.2 0.057 13.4 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Saf_2TM PF18303.1 VDM92117.1 - 0.019 14.6 0.1 0.037 13.6 0.1 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Kelch_6 PF13964.6 VDM92117.1 - 0.093 13.1 1.5 35 4.9 0.1 4.0 3 1 0 3 3 3 0 Kelch motif Tubulin_C PF03953.17 VDM92121.1 - 0.017 15.3 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Tubulin C-terminal domain Tubulin PF00091.25 VDM92122.1 - 8.6e-23 81.6 4.0 8.2e-19 68.6 0.1 2.0 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain zf-ribbon_3 PF13248.6 VDM92122.1 - 0.17 11.3 3.2 0.29 10.6 3.2 1.3 1 0 0 1 1 1 0 zinc-ribbon domain Tubulin PF00091.25 VDM92123.1 - 2.9e-52 177.7 0.0 5e-52 177.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 VDM92123.1 - 7.2e-18 65.0 0.0 1.3e-17 64.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 VDM92123.1 - 0.0032 17.2 0.0 0.012 15.3 0.0 1.9 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.9 VDM92123.1 - 0.0075 16.6 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Mito_fiss_reg PF05308.11 VDM92127.1 - 0.072 13.2 1.7 0.11 12.6 1.7 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator AMP-binding PF00501.28 VDM92131.1 - 1.4e-60 205.1 0.0 1.7e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme DUF1681 PF07933.14 VDM92131.1 - 0.071 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) Peptidase_S49_N PF08496.10 VDM92134.1 - 3 7.9 9.9 1.6 8.7 4.2 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal cNMP_binding PF00027.29 VDM92136.1 - 1.6e-15 56.9 0.0 2.8e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CLZ PF16526.5 VDM92136.1 - 0.001 19.3 0.5 0.0036 17.6 0.4 2.1 1 1 1 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3461 PF11944.8 VDM92136.1 - 0.0023 18.1 0.1 0.0059 16.7 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3461) GvpK PF05121.12 VDM92136.1 - 0.015 15.3 0.2 0.035 14.1 0.2 1.6 1 0 0 1 1 1 0 Gas vesicle protein K DUF948 PF06103.11 VDM92136.1 - 0.1 12.9 0.1 1.7 8.9 0.0 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Pro_isomerase PF00160.21 VDM92139.1 - 1.5e-48 165.1 0.2 1.7e-48 164.9 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ras PF00071.22 VDM92140.1 - 9.6e-58 194.4 0.1 1.2e-57 194.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDM92140.1 - 6.8e-36 123.1 0.0 1.2e-35 122.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDM92140.1 - 2.5e-13 49.9 0.1 3e-13 49.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 VDM92140.1 - 9.7e-06 25.1 0.0 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 VDM92140.1 - 0.00081 19.4 0.0 0.0027 17.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 VDM92140.1 - 0.0012 18.3 0.0 0.066 12.7 0.0 2.2 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 VDM92140.1 - 0.0015 18.3 0.2 0.029 14.1 0.2 2.1 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 VDM92140.1 - 0.003 17.5 0.4 0.63 9.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 VDM92140.1 - 0.0038 16.8 0.1 0.0092 15.5 0.1 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 VDM92140.1 - 0.0095 15.5 0.3 0.18 11.3 0.3 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B SRCR PF00530.18 VDM92148.1 - 1.6e-13 51.0 0.1 3.7e-13 49.8 0.1 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain SRCR_2 PF15494.6 VDM92148.1 - 6e-05 23.5 0.3 0.00013 22.4 0.3 1.6 1 0 0 1 1 1 1 Scavenger receptor cysteine-rich domain Beta_helix PF13229.6 VDM92148.1 - 0.047 13.6 25.5 0.071 13.0 1.0 3.7 2 1 1 3 3 3 0 Right handed beta helix region DUF4905 PF16248.5 VDM92148.1 - 0.081 12.8 0.2 2.1 8.3 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4905) Hepsin-SRCR PF09272.10 VDM92148.1 - 0.14 12.7 0.0 0.37 11.3 0.0 1.6 1 0 0 1 1 1 0 Hepsin, SRCR domain DB PF01682.19 VDM92152.1 - 4.4e-18 65.4 5.3 4.9e-18 65.3 5.3 1.0 1 0 0 1 1 1 1 DB module BTG PF07742.12 VDM92153.1 - 1.1e-22 80.1 0.0 2.6e-22 78.9 0.0 1.7 2 0 0 2 2 2 1 BTG family AfaD PF05775.12 VDM92153.1 - 0.0052 17.2 0.2 0.011 16.2 0.2 1.5 1 0 0 1 1 1 1 Enterobacteria AfaD invasin protein RabGAP-TBC PF00566.18 VDM92155.1 - 2e-52 178.0 0.7 2.7e-52 177.5 0.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Argos PF11581.8 VDM92155.1 - 0.14 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Antagonist of EGFR signalling, Argos Mon2_C PF16206.5 VDM92159.1 - 5.4e-76 256.4 5.0 7.1e-69 232.8 3.7 3.2 2 1 0 2 2 2 2 C-terminal region of Mon2 protein Sec7_N PF12783.7 VDM92159.1 - 8.2e-35 120.0 1.2 8.2e-35 120.0 1.2 3.3 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 VDM92159.1 - 4.7e-07 29.6 0.8 6.6e-06 25.9 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) HEAT PF02985.22 VDM92159.1 - 0.0017 18.5 0.2 2.8 8.4 0.1 4.8 4 0 0 4 4 4 1 HEAT repeat Zn-ribbon_8 PF09723.10 VDM92160.1 - 0.00039 20.5 2.1 0.08 13.1 0.1 2.4 2 0 0 2 2 2 2 Zinc ribbon domain zf-ribbon_3 PF13248.6 VDM92160.1 - 0.0034 16.7 1.7 1.3 8.6 0.1 2.5 2 0 0 2 2 2 2 zinc-ribbon domain CpXC PF14353.6 VDM92160.1 - 0.028 14.5 0.8 0.18 11.9 0.0 2.2 2 0 0 2 2 2 0 CpXC protein zinc_ribbon_2 PF13240.6 VDM92160.1 - 0.049 13.4 2.4 4 7.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Succ_DH_flav_C PF02910.20 VDM92160.1 - 0.067 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Fumarate reductase flavoprotein C-term zinc_ribbon_5 PF13719.6 VDM92160.1 - 0.13 12.1 1.9 0.82 9.5 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-IS66 PF13005.7 VDM92160.1 - 0.16 12.4 1.6 2.1 8.8 0.1 2.4 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Ogr_Delta PF04606.12 VDM92160.1 - 0.23 11.5 4.6 1.5 8.9 0.5 2.4 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Nudix_N_2 PF14803.6 VDM92160.1 - 0.3 11.0 1.6 23 5.0 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal zinc_ribbon_9 PF14369.6 VDM92160.1 - 0.35 11.2 1.9 16 5.9 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon YhfH PF14149.6 VDM92160.1 - 0.53 10.3 2.5 3.5 7.7 0.1 2.3 2 0 0 2 2 2 0 YhfH-like protein UPF0547 PF10571.9 VDM92160.1 - 0.78 9.9 5.0 5 7.3 0.4 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-H2C2_2 PF13465.6 VDM92160.1 - 7.2 7.2 11.1 6.7 7.3 0.1 3.3 3 1 0 3 3 3 0 Zinc-finger double domain zf-C2HC_2 PF13913.6 VDM92160.1 - 8 6.5 6.9 34 4.5 0.9 2.7 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Ank_2 PF12796.7 VDM92167.1 - 2e-22 79.6 3.0 1.7e-13 50.9 0.4 3.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDM92167.1 - 2.8e-20 72.4 3.0 6.7e-11 42.5 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDM92167.1 - 8.6e-20 70.6 5.8 1.6e-06 28.3 0.2 4.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 VDM92167.1 - 1.2e-17 63.5 3.8 2.6e-07 30.8 0.1 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 VDM92167.1 - 2.6e-16 58.1 1.2 3.4e-06 27.0 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Glyco_hydro_20b PF02838.15 VDM92167.1 - 3.8e-05 24.5 0.0 8.9e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 PF14845.6 VDM92167.1 - 0.0088 16.7 0.0 0.056 14.1 0.0 2.2 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like PGA2 PF07543.12 VDM92168.1 - 0.31 11.0 3.5 0.37 10.8 3.5 1.1 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF1041 PF06292.17 VDM92169.1 - 7.7e-18 64.8 11.1 2.2e-17 63.4 5.1 3.7 3 2 1 4 4 4 1 Domain of Unknown Function (DUF1041) Membr_traf_MHD PF10540.9 VDM92169.1 - 0.00045 20.4 0.3 0.00045 20.4 0.3 2.8 2 1 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain Ribosomal_L19e PF01280.20 VDM92169.1 - 0.2 11.7 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L19e Dynamin_M PF01031.20 VDM92169.1 - 0.22 10.7 2.8 0.66 9.1 1.4 2.2 1 1 1 2 2 2 0 Dynamin central region NepR PF18557.1 VDM92170.1 - 0.063 12.9 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 Anti-sigma factor NepR DUF3677 PF12432.8 VDM92171.1 - 6.4e-24 84.1 1.0 2.5e-23 82.2 1.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3677) CNOT11 PF10155.9 VDM92171.1 - 0.018 15.2 1.3 4.1 7.6 0.1 3.4 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 CH PF00307.31 VDM92172.1 - 1.9e-18 66.6 0.1 2.5e-18 66.2 0.1 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 VDM92172.1 - 4.5e-14 51.8 0.1 6.8e-14 51.2 0.1 1.3 1 0 0 1 1 1 1 Calponin family repeat SepF PF04472.12 VDM92172.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Cell division protein SepF zf-C2HC PF01530.18 VDM92173.1 - 1.2e-25 89.4 24.7 6.8e-13 48.6 6.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2HC type Ribosomal_60s PF00428.19 VDM92173.1 - 3.2 8.4 12.4 2.7 8.6 6.8 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pkinase PF00069.25 VDM92179.1 - 2.3e-69 233.7 0.0 2.7e-69 233.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM92179.1 - 2.4e-41 141.7 0.0 2.9e-41 141.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDM92179.1 - 1.5e-06 27.4 0.1 1.9e-06 27.1 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 VDM92179.1 - 6.7e-06 25.6 0.1 1.5e-05 24.4 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 VDM92179.1 - 0.00033 20.3 0.2 0.00052 19.7 0.2 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 VDM92179.1 - 0.012 15.5 0.1 0.53 10.2 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family DRY_EERY PF09750.9 VDM92180.1 - 4.9e-23 81.9 0.4 4.9e-23 81.9 0.4 1.5 2 0 0 2 2 2 1 Alternative splicing regulator F420H2_quin_red PF04075.14 VDM92180.1 - 0.061 13.4 0.0 0.078 13.1 0.0 1.3 1 1 0 1 1 1 0 F420H(2)-dependent quinone reductase TFIIA PF03153.13 VDM92184.1 - 0.051 13.6 15.2 0.061 13.3 15.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PIEZO PF15917.5 VDM92184.1 - 0.16 11.4 4.6 0.27 10.7 4.6 1.2 1 0 0 1 1 1 0 Piezo Activator_LAG-3 PF11498.8 VDM92184.1 - 0.27 10.2 23.1 0.32 9.9 23.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 PepSY_TM PF03929.16 VDM92184.1 - 1.8 8.1 3.8 6.9 6.2 3.8 1.8 1 1 0 1 1 1 0 PepSY-associated TM region Thioredoxin_14 PF18402.1 VDM92188.1 - 5.8e-51 173.9 3.0 1.3e-48 166.2 0.1 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 VDM92188.1 - 4.1e-44 150.8 0.2 4.1e-44 150.8 0.2 1.6 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 VDM92188.1 - 7.4e-33 113.4 2.2 1.1e-32 112.8 1.0 1.9 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 VDM92188.1 - 1.6e-06 28.2 0.1 0.00053 20.0 0.0 2.7 2 1 0 2 2 2 2 Thioredoxin-like domain BTG PF07742.12 VDM92192.1 - 3.3e-22 78.5 0.0 7.6e-22 77.3 0.0 1.7 1 0 0 1 1 1 1 BTG family AfaD PF05775.12 VDM92192.1 - 0.015 15.7 0.2 0.03 14.8 0.2 1.4 1 0 0 1 1 1 0 Enterobacteria AfaD invasin protein DUF3149 PF11346.8 VDM92198.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) IMPDH PF00478.25 VDM92203.1 - 0.039 13.0 0.2 0.048 12.6 0.2 1.1 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain Spectrin PF00435.21 VDM92204.1 - 3.6e-119 390.6 98.1 1.3e-21 77.1 3.4 9.0 9 0 0 9 9 9 9 Spectrin repeat Inhibitor_I29 PF08246.12 VDM92204.1 - 0.1 13.1 0.5 1.3 9.5 0.1 2.9 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) DBD_Tnp_Mut PF03108.15 VDM92204.1 - 0.13 12.3 0.2 1.1 9.3 0.1 2.5 2 0 0 2 2 2 0 MuDR family transposase eIF-5_eIF-2B PF01873.17 VDM92204.1 - 0.34 10.8 2.4 4.8 7.1 0.1 3.1 3 0 0 3 3 3 0 Domain found in IF2B/IF5 PP2C PF00481.21 VDM92209.1 - 2e-54 185.0 0.2 2.8e-54 184.5 0.2 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C LSM PF01423.22 VDM92210.1 - 5.1e-19 67.7 0.2 4e-18 64.9 0.0 2.0 2 0 0 2 2 2 1 LSM domain GRP PF07172.11 VDM92210.1 - 0.023 15.4 4.2 0.037 14.7 4.2 1.3 1 0 0 1 1 1 0 Glycine rich protein family SM-ATX PF14438.6 VDM92210.1 - 0.091 12.9 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain EF-hand_1 PF00036.32 VDM92212.1 - 2.8e-41 136.0 10.9 3.3e-10 38.8 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 VDM92212.1 - 3.1e-33 114.1 5.1 2.7e-17 63.0 2.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 VDM92212.1 - 7.8e-32 108.9 12.9 7e-13 48.2 2.2 4.2 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 VDM92212.1 - 8.8e-30 100.1 4.0 4.6e-09 35.5 0.1 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 VDM92212.1 - 9.6e-23 78.6 6.1 4.5e-06 25.9 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 VDM92212.1 - 2.3e-12 47.0 0.1 1.2e-05 25.5 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 VDM92212.1 - 1.1e-06 28.6 1.9 0.027 14.4 0.4 3.2 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 VDM92212.1 - 0.00023 21.1 0.0 3.2 7.9 0.0 3.4 3 0 0 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 VDM92212.1 - 0.00038 21.3 0.1 0.002 18.9 0.1 1.9 1 1 1 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 VDM92212.1 - 0.0009 19.6 0.1 1.6 9.1 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EFhand_Ca_insen PF08726.10 VDM92212.1 - 0.00097 19.2 1.7 0.0014 18.7 0.3 2.0 2 1 0 2 2 2 1 Ca2+ insensitive EF hand Dockerin_1 PF00404.18 VDM92212.1 - 0.0084 16.3 0.6 0.5 10.6 0.1 3.0 1 1 1 2 2 2 1 Dockerin type I domain Caleosin PF05042.13 VDM92212.1 - 0.016 15.2 0.7 12 5.7 0.0 3.5 1 1 3 4 4 4 0 Caleosin related protein PY_rept_46 PF09689.10 VDM92212.1 - 0.031 14.8 0.7 5.8 7.6 0.7 2.6 2 0 0 2 2 2 0 Plasmodium yoelii repeat (PY_rept_46) Phage_TAC_12 PF12363.8 VDM92212.1 - 0.076 13.4 0.0 0.97 9.9 0.0 2.1 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC PMBR PF09373.10 VDM92212.1 - 0.084 13.1 0.0 1.1e+02 3.2 0.0 4.2 5 0 0 5 5 5 0 Pseudomurein-binding repeat EF-hand_10 PF14788.6 VDM92212.1 - 4.3 7.3 7.8 0.54 10.2 0.3 3.3 4 1 1 5 5 5 0 EF hand PTB PF08416.13 VDM92213.1 - 7.8e-36 123.1 0.0 1.3e-35 122.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotyrosine-binding domain SH2 PF00017.24 VDM92213.1 - 9.1e-12 44.9 0.0 2.7e-11 43.4 0.0 1.9 1 0 0 1 1 1 1 SH2 domain PAP2_C PF14360.6 VDM92215.1 - 3.2e-22 78.9 9.6 3.2e-22 78.9 9.6 2.6 2 1 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 VDM92215.1 - 0.0037 17.0 2.4 0.0037 17.0 2.4 2.3 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 VDM92215.1 - 0.14 11.8 13.9 0.31 10.7 13.9 1.5 1 1 0 1 1 1 0 PAP2 superfamily BAR PF03114.18 VDM92216.1 - 1.6e-10 41.0 5.2 1.9e-10 40.8 5.2 1.0 1 0 0 1 1 1 1 BAR domain Com_YlbF PF06133.11 VDM92216.1 - 0.005 17.4 0.2 0.005 17.4 0.2 2.4 2 1 0 2 2 2 1 Control of competence regulator ComK, YlbF/YmcA LsmAD PF06741.13 VDM92216.1 - 0.04 14.5 1.0 0.099 13.2 1.0 1.6 1 0 0 1 1 1 0 LsmAD domain DUF5367 PF17329.2 VDM92216.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5367) DMAP_binding PF06464.11 VDM92221.1 - 8.4e-24 84.5 3.9 8.4e-24 84.5 3.9 2.8 1 1 2 3 3 3 1 DMAP1-binding Domain GvpG PF05120.12 VDM92221.1 - 0.00012 22.0 0.0 0.00039 20.4 0.0 1.9 1 0 0 1 1 1 1 Gas vesicle protein G Asp PF00026.23 VDM92223.1 - 2.1e-07 30.6 0.0 2.5e-07 30.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp PF00026.23 VDM92224.1 - 2.1e-07 30.7 0.0 2.6e-07 30.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease tRNA_SAD PF07973.14 VDM92226.1 - 0.0012 18.9 0.0 0.0024 17.9 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Pkinase PF00069.25 VDM92228.1 - 1.6e-17 63.8 0.0 1.9e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM92228.1 - 3.2e-10 39.7 0.0 4.4e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 VDM92228.1 - 1.7e-05 23.8 0.0 4.2e-05 22.5 0.0 1.6 1 1 1 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 VDM92228.1 - 0.00088 19.0 0.0 0.12 11.9 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pro_3_hydrox_C PF05373.11 VDM92228.1 - 0.0067 16.5 0.1 0.018 15.1 0.1 1.6 1 1 0 1 1 1 1 L-proline 3-hydroxylase, C-terminal Kunitz_BPTI PF00014.23 VDM92229.1 - 5.5e-13 48.9 4.7 5.5e-13 48.9 4.7 2.0 2 0 0 2 2 2 1 Kunitz/Bovine pancreatic trypsin inhibitor domain AMP-binding PF00501.28 VDM92231.1 - 1.8e-88 297.0 0.0 2.7e-88 296.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 VDM92231.1 - 0.00032 21.6 0.0 0.00075 20.4 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SWI2_SNF2 PF18766.1 VDM92231.1 - 0.05 13.3 0.4 0.16 11.6 0.1 1.8 2 0 0 2 2 2 0 SWI2/SNF2 ATPase 7tm_1 PF00001.21 VDM92235.1 - 1.4e-47 162.3 9.6 1.8e-47 161.9 9.6 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDM92235.1 - 4e-07 29.7 8.4 5.4e-07 29.3 8.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7tm_4 PF13853.6 VDM92235.1 - 5.8e-07 29.5 4.2 9.1e-07 28.9 4.2 1.4 1 1 0 1 1 1 1 Olfactory receptor 7TM_GPCR_Srbc PF10316.9 VDM92235.1 - 6.8e-07 29.1 7.0 6.8e-07 29.1 7.0 1.8 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srbc 7TM_GPCR_Srx PF10328.9 VDM92235.1 - 0.0012 18.5 12.8 0.0022 17.7 12.8 1.5 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Saf_2TM PF18303.1 VDM92235.1 - 0.74 9.4 5.1 11 5.6 0.1 2.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF2417 PF10329.9 VDM92235.1 - 7.8 5.8 10.4 1.6 8.1 5.9 2.0 2 1 0 2 2 2 0 Region of unknown function (DUF2417) An_peroxidase PF03098.15 VDM92238.1 - 1.9e-101 340.2 0.0 2.2e-101 340.1 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase MyTH4 PF00784.17 VDM92240.1 - 4.3e-17 62.6 0.9 1.4e-16 60.9 0.1 2.3 2 0 0 2 2 2 1 MyTH4 domain IQ PF00612.27 VDM92240.1 - 4.1e-08 32.3 4.3 0.002 17.7 0.3 3.0 2 0 0 2 2 2 2 IQ calmodulin-binding motif Metallophos PF00149.28 VDM92242.1 - 3.1e-30 106.2 0.0 4.3e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Engrail_1_C_sig PF10525.9 VDM92242.1 - 0.13 11.5 0.3 0.27 10.5 0.3 1.4 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain Far-17a_AIG1 PF04750.14 VDM92243.1 - 1e-39 136.0 12.9 1.1e-39 135.8 12.9 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein NMN_transporter PF04973.12 VDM92243.1 - 1.9 8.4 14.1 3.2 7.7 14.1 1.7 1 1 0 1 1 1 0 Nicotinamide mononucleotide transporter Hydrolase_like PF13242.6 VDM92246.1 - 1.9e-16 59.9 0.1 4e-16 58.8 0.1 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 VDM92246.1 - 4.5e-14 52.4 0.0 6.5e-14 51.9 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 VDM92246.1 - 3e-08 34.0 0.1 1.6e-07 31.6 0.1 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 VDM92246.1 - 5.4e-07 30.1 1.2 9.2e-06 26.1 1.2 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 VDM92246.1 - 0.0076 15.9 0.2 0.17 11.5 0.2 2.1 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase BLUF PF04940.12 VDM92246.1 - 0.098 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Sensors of blue-light using FAD Ion_trans PF00520.31 VDM92249.1 - 3.4e-09 36.3 6.2 4.9e-09 35.8 6.2 1.2 1 0 0 1 1 1 1 Ion transport protein Serglycin PF04360.12 VDM92249.1 - 0.25 11.3 3.5 0.61 10.0 3.5 1.6 1 0 0 1 1 1 0 Serglycin SR-25 PF10500.9 VDM92249.1 - 2 8.0 15.2 0.026 14.2 3.7 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein NUDE_C PF04880.13 VDM92253.1 - 4.7 7.7 16.0 3 8.3 14.2 1.6 2 0 0 2 2 2 0 NUDE protein, C-terminal conserved region DUF5387 PF17361.2 VDM92255.1 - 0.0034 17.1 0.2 0.0034 17.1 0.2 1.9 2 1 0 2 2 2 1 Family of unknown function (DUF5387) Syntaphilin PF15290.6 VDM92255.1 - 0.0072 16.0 0.7 0.012 15.3 0.2 1.7 1 1 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp Caldesmon PF02029.15 VDM92255.1 - 0.012 14.4 0.1 0.02 13.7 0.1 1.2 1 0 0 1 1 1 0 Caldesmon Pet127 PF08634.10 VDM92255.1 - 0.06 12.8 0.1 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 Mitochondrial protein Pet127 Vps54 PF07928.12 VDM92260.1 - 4.1e-43 147.0 0.3 4.1e-43 147.0 0.3 2.2 3 0 0 3 3 3 1 Vps54-like protein DUF2764 PF10962.8 VDM92260.1 - 0.07 12.6 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2764) DUF1480 PF07351.13 VDM92260.1 - 0.13 12.6 0.1 2 8.8 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1480) PI3_PI4_kinase PF00454.27 VDM92265.1 - 7.9e-73 245.3 0.2 1.2e-72 244.7 0.2 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 VDM92265.1 - 5.4e-24 84.5 3.0 8.2e-24 83.9 0.8 2.1 2 0 0 2 2 2 1 FKBP12-rapamycin binding domain FATC PF02260.20 VDM92265.1 - 1.7e-14 53.3 0.4 3.4e-14 52.3 0.4 1.6 1 0 0 1 1 1 1 FATC domain PAS_4 PF08448.10 VDM92269.1 - 0.0036 17.5 0.0 0.021 15.0 0.0 2.2 1 1 1 2 2 2 1 PAS fold PAS PF00989.25 VDM92269.1 - 0.0088 16.0 0.0 0.037 14.0 0.0 2.1 1 1 0 1 1 1 1 PAS fold Cytochrom_B561 PF03188.16 VDM92271.1 - 1.5e-32 112.6 4.5 1.9e-32 112.2 4.5 1.2 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Motile_Sperm PF00635.26 VDM92272.1 - 1.3e-18 66.9 0.0 2e-17 63.0 0.0 2.0 1 1 0 1 1 1 1 MSP (Major sperm protein) domain Caenor_Her-1 PF09232.10 VDM92275.1 - 0.003 17.7 1.7 0.0049 17.0 1.7 1.4 1 0 0 1 1 1 1 Caenorhabditis elegans Her-1 UPF0640 PF15114.6 VDM92276.1 - 1.1e-06 28.4 0.5 1.5e-06 27.9 0.5 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0640 Insulin_TMD PF17870.1 VDM92276.1 - 0.019 15.0 2.6 0.6 10.2 1.7 2.2 1 1 1 2 2 2 0 Insulin receptor trans-membrane segment wnt PF00110.19 VDM92279.1 - 7.3e-89 298.4 19.1 8.5e-89 298.2 19.1 1.0 1 0 0 1 1 1 1 wnt family Homeodomain PF00046.29 VDM92281.1 - 2.8e-14 52.7 4.0 6.5e-14 51.5 4.0 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 VDM92281.1 - 0.12 12.3 0.5 0.12 12.3 0.5 2.7 3 0 0 3 3 3 0 Homeobox KN domain SelP_N PF04592.14 VDM92281.1 - 2.2 7.6 10.2 3.9 6.8 8.2 2.0 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Trypsin PF00089.26 VDM92283.1 - 0.01 15.6 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 Trypsin T_cell_tran_alt PF15128.6 VDM92284.1 - 0.065 13.0 1.3 0.18 11.6 1.3 1.8 1 0 0 1 1 1 0 T-cell leukemia translocation-altered zf-H2C2_2 PF13465.6 VDM92286.1 - 5e-37 124.7 24.8 1.1e-08 35.0 1.2 5.7 5 0 0 5 5 5 5 Zinc-finger double domain zf-C2H2 PF00096.26 VDM92286.1 - 6.9e-24 82.9 36.2 1.7e-05 25.0 0.5 6.0 6 0 0 6 6 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDM92286.1 - 2e-14 53.0 37.0 0.0011 19.6 0.5 6.1 6 0 0 6 6 5 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDM92286.1 - 2.7e-09 37.1 22.9 0.0014 18.9 0.1 5.5 5 1 0 5 5 5 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 VDM92286.1 - 8.5e-05 22.8 4.5 0.0018 18.6 0.5 5.6 6 0 0 6 6 5 3 Zinc-finger of C2H2 type C1_4 PF07975.12 VDM92286.1 - 0.00041 20.5 15.6 1.1 9.6 0.5 4.6 1 1 2 3 3 3 2 TFIIH C1-like domain zf-C2H2_6 PF13912.6 VDM92286.1 - 0.00064 19.7 24.8 0.35 10.9 0.9 5.5 5 0 0 5 5 5 3 C2H2-type zinc finger PyrI_C PF02748.15 VDM92286.1 - 0.016 15.1 19.4 0.14 12.1 1.6 5.0 3 1 2 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF3268 PF11672.8 VDM92286.1 - 0.035 14.4 15.2 0.24 11.8 2.7 3.3 2 1 1 3 3 3 0 zinc-finger-containing domain zf-C2HE PF16278.5 VDM92286.1 - 0.063 13.7 18.3 0.38 11.2 0.9 4.4 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 VDM92286.1 - 0.091 12.5 13.6 11 5.9 0.1 5.3 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-MYST PF17772.1 VDM92286.1 - 0.12 12.0 12.7 2.2 7.9 0.0 4.2 4 1 1 5 5 5 0 MYST family zinc finger domain DUF3280 PF11684.8 VDM92286.1 - 0.21 12.0 0.1 0.42 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2380) zf-C2H2_3rep PF18868.1 VDM92286.1 - 1.1 10.0 11.9 6.3 7.5 3.3 4.0 1 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 VDM92286.1 - 1.1 9.3 21.9 0.75 9.9 1.0 4.7 3 1 2 5 5 4 0 BED zinc finger DZR PF12773.7 VDM92286.1 - 1.3 9.1 17.1 1.6 8.8 0.7 3.7 2 1 0 2 2 2 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 VDM92286.1 - 2.5 8.3 21.2 1.3 9.3 3.4 4.5 3 2 1 4 4 4 0 Zinc ribbon domain zinc_ribbon_15 PF17032.5 VDM92286.1 - 4.6 8.1 16.7 3.7 8.4 0.5 3.5 1 1 4 5 5 5 0 zinc-ribbon family CpXC PF14353.6 VDM92286.1 - 4.7 7.3 13.5 4.9 7.2 0.1 3.9 1 1 3 4 4 4 0 CpXC protein zf-Di19 PF05605.12 VDM92286.1 - 7.9 6.9 20.3 1.2 9.5 2.1 4.0 2 2 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 VDM92286.1 - 8.2 6.7 26.5 10 6.4 0.2 5.9 7 0 0 7 7 5 0 AN1-like Zinc finger Zn_ribbon_SprT PF17283.2 VDM92286.1 - 8.6 6.4 18.0 0.44 10.5 3.7 3.9 3 1 1 4 4 4 0 SprT-like zinc ribbon domain Tropomyosin PF00261.20 VDM92287.1 - 7.4e-30 104.1 14.3 8e-30 104.0 14.3 1.0 1 0 0 1 1 1 1 Tropomyosin DUF4472 PF14739.6 VDM92287.1 - 0.019 15.7 8.3 0.02 15.6 8.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) Laminin_II PF06009.12 VDM92287.1 - 0.021 14.9 3.6 0.026 14.6 3.6 1.1 1 0 0 1 1 1 0 Laminin Domain II SlyX PF04102.12 VDM92287.1 - 0.022 15.4 5.2 0.41 11.3 0.7 2.3 1 1 0 2 2 2 0 SlyX Tropomyosin_1 PF12718.7 VDM92287.1 - 0.037 14.2 12.1 0.24 11.6 12.1 2.0 1 1 0 1 1 1 0 Tropomyosin like DUF5595 PF18077.1 VDM92287.1 - 0.037 14.1 5.3 0.04 14.0 2.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5595) Vps53_N PF04100.12 VDM92287.1 - 0.083 11.8 3.5 0.095 11.6 3.5 1.0 1 0 0 1 1 1 0 Vps53-like, N-terminal DUF1664 PF07889.12 VDM92287.1 - 0.14 12.2 3.2 0.16 12.0 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DcrB PF08786.11 VDM92287.1 - 0.19 11.9 3.3 0.64 10.1 1.0 2.0 1 1 1 2 2 2 0 DcrB FlaC_arch PF05377.11 VDM92287.1 - 0.19 12.2 7.1 0.37 11.2 0.7 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 VDM92287.1 - 0.2 12.2 4.8 0.4 11.2 1.3 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 XhlA PF10779.9 VDM92287.1 - 0.28 11.4 6.6 0.8 10.0 1.0 2.1 1 1 1 2 2 2 0 Haemolysin XhlA TMPIT PF07851.13 VDM92287.1 - 0.42 9.8 4.5 0.42 9.8 4.5 1.0 1 0 0 1 1 1 0 TMPIT-like protein 5_nucleotid PF05761.14 VDM92287.1 - 2.8 6.8 6.5 3.2 6.6 6.5 1.0 1 0 0 1 1 1 0 5' nucleotidase family V_ATPase_I PF01496.19 VDM92287.1 - 2.9 5.7 5.9 3 5.7 5.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc24 PF08286.11 VDM92287.1 - 5.2 7.4 8.5 1.7 8.9 2.2 2.0 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Trimer_CC PF08954.11 VDM92287.1 - 7 6.3 16.0 0.23 11.0 5.8 2.8 1 1 1 2 2 2 0 Trimerisation motif Ank_2 PF12796.7 VDM92289.1 - 3.6e-26 91.6 4.5 1.3e-13 51.4 0.0 3.7 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDM92289.1 - 7.3e-19 65.9 15.3 0.002 18.4 0.1 7.0 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 VDM92289.1 - 8.3e-19 67.1 14.4 1.8e-06 28.1 0.2 7.0 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 VDM92289.1 - 7.1e-17 61.3 9.8 9.4e-06 25.8 0.1 5.7 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 VDM92289.1 - 1.7e-15 57.1 8.9 0.00026 21.5 0.1 5.3 4 1 1 5 5 5 4 Ankyrin repeats (many copies) AMNp_N PF10423.9 VDM92289.1 - 0.084 12.5 0.0 1.3 8.6 0.0 2.6 3 0 0 3 3 3 0 Bacterial AMP nucleoside phosphorylase N-terminus Pkinase PF00069.25 VDM92292.1 - 1.9e-55 188.1 0.0 2.5e-55 187.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PH_3 PF14593.6 VDM92292.1 - 1.1e-41 141.1 0.0 2e-41 140.3 0.0 1.4 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 VDM92292.1 - 1.7e-27 96.3 0.0 4.1e-27 95.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDM92292.1 - 9e-06 25.2 0.0 0.00025 20.5 0.0 2.6 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 VDM92292.1 - 9.3e-05 21.4 0.0 0.00021 20.2 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 VDM92292.1 - 0.00026 20.1 0.1 0.00039 19.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 VDM92292.1 - 0.00041 20.0 0.0 0.97 9.0 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 VDM92292.1 - 0.003 16.9 0.0 0.0056 16.0 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 VDM92292.1 - 0.028 14.3 0.4 0.15 12.0 0.1 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 VDM92292.1 - 0.079 12.6 0.1 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 RIO1 family Ion_trans_2 PF07885.16 VDM92294.1 - 1.2e-23 82.8 13.2 6.7e-14 51.6 0.1 2.8 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 VDM92294.1 - 3.3e-05 23.3 8.1 0.0034 16.7 0.5 2.3 2 0 0 2 2 2 2 Ion transport protein Lig_chan PF00060.26 VDM92294.1 - 0.0016 18.3 0.2 0.017 14.9 0.0 2.3 1 1 0 2 2 2 1 Ligand-gated ion channel IRK PF01007.20 VDM92294.1 - 0.043 13.6 0.1 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain zf-C3HC4_3 PF13920.6 VDM92295.1 - 1.1e-09 38.0 15.2 1.1e-09 38.0 15.2 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 VDM92295.1 - 0.00028 20.7 15.6 0.00066 19.5 15.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PTEN_C2 PF10409.9 VDM92303.1 - 1.5e-11 44.2 0.1 2.4e-11 43.5 0.1 1.2 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 VDM92303.1 - 0.00085 19.1 0.0 0.0015 18.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 VDM92303.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase CDKN3 PF05706.12 VDM92303.1 - 0.099 12.3 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) CENP-B_dimeris PF09026.10 VDM92306.1 - 0.24 11.8 4.7 0.12 12.7 2.6 1.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SH3_9 PF14604.6 VDM92307.1 - 6.5e-05 22.7 0.0 0.00016 21.4 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 VDM92307.1 - 0.0012 18.5 0.0 0.0018 17.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain cNMP_binding PF00027.29 VDM92312.1 - 4.7e-41 138.8 0.7 1.9e-20 72.7 0.1 3.5 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase PF00069.25 VDM92312.1 - 7.9e-35 120.5 2.4 2.6e-34 118.8 0.0 2.8 4 1 1 5 5 5 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM92312.1 - 5.1e-18 65.3 0.6 2e-17 63.3 0.1 2.1 3 0 0 3 3 3 1 Protein tyrosine kinase Vps54_N PF10475.9 VDM92312.1 - 0.00043 19.7 3.6 0.00078 18.8 3.6 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Fib_alpha PF08702.10 VDM92312.1 - 0.0011 19.2 7.1 0.0011 19.2 7.1 1.9 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family Spc29 PF17082.5 VDM92312.1 - 0.01 15.7 5.0 0.014 15.3 4.3 1.5 1 1 0 1 1 1 0 Spindle Pole Component 29 Baculo_PEP_C PF04513.12 VDM92312.1 - 0.012 15.7 1.6 0.023 14.7 0.7 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF16 PF01519.16 VDM92312.1 - 0.014 15.9 4.6 0.014 15.9 4.6 2.1 2 0 0 2 2 1 0 Protein of unknown function DUF16 TSC22 PF01166.18 VDM92312.1 - 0.019 15.3 3.0 0.12 12.7 0.5 3.2 2 2 0 2 2 2 0 TSC-22/dip/bun family CorA PF01544.18 VDM92312.1 - 0.05 12.9 2.0 0.11 11.8 2.0 1.5 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein FliD_N PF02465.18 VDM92312.1 - 0.051 14.3 5.2 0.11 13.2 4.7 1.9 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus SlyX PF04102.12 VDM92312.1 - 0.063 13.9 5.3 0.33 11.6 5.3 2.4 1 0 0 1 1 1 0 SlyX kleA_kleC PF17383.2 VDM92312.1 - 0.089 13.1 3.3 0.22 11.8 0.9 2.6 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A DUF641 PF04859.12 VDM92312.1 - 0.11 12.9 4.7 0.29 11.5 4.7 1.7 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) V_ATPase_I PF01496.19 VDM92312.1 - 0.12 10.2 2.0 0.15 9.9 2.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1192 PF06698.11 VDM92312.1 - 0.16 12.0 3.3 4.9 7.3 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) YkyA PF10368.9 VDM92312.1 - 0.2 11.3 7.2 0.42 10.3 7.2 1.5 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein MCPsignal PF00015.21 VDM92312.1 - 0.25 11.1 5.1 0.2 11.5 3.1 1.8 2 0 0 2 2 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain USP8_interact PF08941.10 VDM92312.1 - 0.27 11.0 2.9 0.64 9.8 2.9 1.7 1 0 0 1 1 1 0 USP8 interacting BLOC1_2 PF10046.9 VDM92312.1 - 0.33 11.3 5.2 0.24 11.7 2.8 2.2 2 0 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tho2 PF11262.8 VDM92312.1 - 0.4 9.8 5.0 1 8.5 4.2 2.0 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF4407 PF14362.6 VDM92312.1 - 0.4 10.0 10.4 0.63 9.3 10.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 VDM92312.1 - 0.46 10.3 9.4 0.053 13.3 3.3 2.6 2 0 0 2 2 2 0 Septum formation initiator DUF3552 PF12072.8 VDM92312.1 - 0.68 9.3 17.8 0.056 12.9 12.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) KLRAQ PF10205.9 VDM92312.1 - 0.82 10.0 10.4 0.18 12.0 6.0 2.1 2 0 0 2 2 1 0 Predicted coiled-coil domain-containing protein Atg14 PF10186.9 VDM92312.1 - 1.1 8.3 14.4 1.7 7.6 14.4 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1043 PF06295.12 VDM92312.1 - 1.2 9.2 7.8 0.84 9.6 5.3 2.0 1 1 0 2 2 1 0 Protein of unknown function (DUF1043) AAA_13 PF13166.6 VDM92312.1 - 1.2 7.7 10.1 1.8 7.1 10.1 1.1 1 0 0 1 1 1 0 AAA domain Phage_GPO PF05929.11 VDM92312.1 - 1.2 8.7 6.8 8.2 6.0 5.5 2.1 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase HIP1_clath_bdg PF16515.5 VDM92312.1 - 1.2 9.8 12.7 0.85 10.3 10.0 2.1 1 1 1 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FAM76 PF16046.5 VDM92312.1 - 1.4 8.3 6.1 2.3 7.5 6.1 1.4 1 0 0 1 1 1 0 FAM76 protein DUF1664 PF07889.12 VDM92312.1 - 1.6 8.8 5.2 5 7.2 5.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 VDM92312.1 - 1.6 9.2 6.6 2.7 8.5 0.5 3.1 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) COG5 PF10392.9 VDM92312.1 - 1.7 8.8 7.6 3.9 7.6 7.6 1.6 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF724 PF05266.14 VDM92312.1 - 1.8 8.3 10.8 0.28 11.0 5.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) YabA PF06156.13 VDM92312.1 - 5 7.8 8.9 1.5 9.5 5.1 2.1 2 0 0 2 2 1 0 Initiation control protein YabA Fzo_mitofusin PF04799.13 VDM92312.1 - 6.6 6.3 8.7 2.7 7.5 6.0 1.7 2 0 0 2 2 2 0 fzo-like conserved region ATG16 PF08614.11 VDM92312.1 - 7 6.8 17.7 2.8 8.1 14.3 1.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF2203 PF09969.9 VDM92312.1 - 7 7.4 7.2 4.2 8.1 4.5 2.1 1 1 1 2 2 1 0 Uncharacterized conserved protein (DUF2203) Guanylate_cyc PF00211.20 VDM92315.1 - 6.4e-54 182.3 0.1 8.8e-54 181.9 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 VDM92315.1 - 0.004 16.6 0.2 0.0064 15.9 0.2 1.3 1 0 0 1 1 1 1 Heme NO binding associated Ribul_P_3_epim PF00834.19 VDM92315.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family adh_short PF00106.25 VDM92316.1 - 1.3e-34 119.3 0.0 1.9e-34 118.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 VDM92316.1 - 6.4e-26 91.4 0.0 9e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 VDM92316.1 - 2.8e-07 30.6 0.0 6.6e-07 29.4 0.0 1.6 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 VDM92316.1 - 0.023 14.2 0.1 1.1 8.7 0.0 2.3 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DUF5357 PF17310.2 VDM92316.1 - 0.077 11.5 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5357) PEGA PF08308.11 VDM92316.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 PEGA domain RINGv PF12906.7 VDM92318.1 - 1.7e-21 76.1 29.5 2.7e-11 43.4 8.9 2.8 3 0 0 3 3 3 2 RING-variant domain Glt_symporter PF03616.14 VDM92318.1 - 0.11 11.1 0.3 0.16 10.6 0.3 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter Rubredoxin PF00301.20 VDM92318.1 - 0.79 9.8 7.8 8.4 6.5 1.4 3.3 3 0 0 3 3 3 0 Rubredoxin DUF587 PF04532.12 VDM92318.1 - 0.96 8.7 8.8 0.21 10.8 1.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF587) LRR_4 PF12799.7 VDM92322.1 - 1.9e-05 24.9 0.0 0.0015 18.9 0.0 3.1 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 VDM92322.1 - 0.045 13.5 1.5 0.42 10.4 0.1 2.6 2 0 0 2 2 2 0 Leucine rich repeat LRR_6 PF13516.6 VDM92322.1 - 0.52 10.5 3.7 1.4 9.2 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich repeat Astacin PF01400.24 VDM92323.1 - 9.1e-20 71.1 0.0 1.3e-19 70.6 0.0 1.2 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) ShK PF01549.24 VDM92323.1 - 4.5e-06 27.1 27.4 0.00048 20.6 1.6 3.6 3 0 0 3 3 3 3 ShK domain-like EGF_CA PF07645.15 VDM92324.1 - 8.3e-06 25.9 6.8 8.3e-06 25.9 6.8 3.7 4 1 1 5 5 5 1 Calcium-binding EGF domain EGF PF00008.27 VDM92324.1 - 0.00027 21.2 9.5 0.019 15.3 0.1 3.9 2 1 0 2 2 2 1 EGF-like domain cEGF PF12662.7 VDM92324.1 - 0.00028 20.7 12.5 0.087 12.8 0.2 4.0 3 0 0 3 3 3 2 Complement Clr-like EGF-like EGF_3 PF12947.7 VDM92324.1 - 0.0069 16.6 5.6 0.05 13.8 0.6 2.8 2 1 0 2 2 2 1 EGF domain EGF_MSP1_1 PF12946.7 VDM92324.1 - 0.015 15.3 6.5 0.015 15.3 6.5 3.1 3 0 0 3 3 3 0 MSP1 EGF domain 1 hEGF PF12661.7 VDM92324.1 - 0.041 14.5 0.9 0.041 14.5 0.9 4.4 6 0 0 6 6 6 0 Human growth factor-like EGF AAA_22 PF13401.6 VDM92330.1 - 0.00027 21.2 0.9 0.00071 19.9 0.1 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 VDM92330.1 - 0.0014 18.6 0.1 0.004 17.1 0.1 1.8 1 0 0 1 1 1 1 NACHT domain DUF4062 PF13271.6 VDM92330.1 - 0.0016 18.8 0.0 0.011 16.1 0.0 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) AAA_16 PF13191.6 VDM92330.1 - 0.024 15.0 0.1 0.23 11.8 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain DUF4476 PF14771.6 VDM92330.1 - 0.053 13.8 0.3 0.22 11.8 0.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) Mucin PF01456.17 VDM92334.1 - 0.016 15.2 25.7 0.018 15.1 25.7 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Homeodomain PF00046.29 VDM92338.1 - 1.5e-19 69.6 0.8 2.6e-19 68.8 0.8 1.4 1 0 0 1 1 1 1 Homeodomain LIM PF00412.22 VDM92338.1 - 2.8e-15 56.3 22.1 1.3e-08 35.0 6.8 2.5 2 0 0 2 2 2 2 LIM domain Homeobox_KN PF05920.11 VDM92338.1 - 0.0011 18.8 0.0 0.0027 17.6 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain MerR PF00376.23 VDM92338.1 - 1.8 8.4 5.7 0.23 11.3 0.7 2.2 2 0 0 2 2 2 0 MerR family regulatory protein Tmemb_55A PF09788.9 VDM92339.1 - 4.8e-06 25.8 0.6 4.8e-06 25.8 0.6 1.7 2 0 0 2 2 2 1 Transmembrane protein 55A zf-H2C2_2 PF13465.6 VDM92339.1 - 0.0077 16.6 1.9 2.3 8.8 0.3 2.4 2 0 0 2 2 2 2 Zinc-finger double domain A2L_zn_ribbon PF08792.10 VDM92339.1 - 0.0083 15.8 0.1 0.016 14.9 0.1 1.5 1 0 0 1 1 1 1 A2L zinc ribbon domain zinc_ribbon_9 PF14369.6 VDM92339.1 - 0.016 15.5 1.8 0.53 10.6 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon Lar_restr_allev PF14354.6 VDM92339.1 - 0.037 14.4 0.8 1.1 9.7 0.0 2.3 2 0 0 2 2 2 0 Restriction alleviation protein Lar zf-TFIIB PF13453.6 VDM92339.1 - 0.049 13.0 0.5 0.5 9.7 0.1 2.3 2 0 0 2 2 2 0 Transcription factor zinc-finger DUF1451 PF07295.11 VDM92339.1 - 0.056 13.5 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain Zn-ribbon_8 PF09723.10 VDM92339.1 - 0.093 12.9 1.0 0.093 12.9 1.0 1.8 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 VDM92339.1 - 0.11 12.5 5.5 1.3 9.0 0.9 2.4 1 1 1 2 2 2 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 VDM92339.1 - 0.26 10.8 3.2 4.7 6.8 3.3 2.4 1 1 1 2 2 2 0 TFIIB zinc-binding TTR-52 PF01060.23 VDM92341.1 - 4.9e-29 100.8 0.0 6.2e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family TTR-52 PF01060.23 VDM92342.1 - 9.8e-27 93.5 0.0 1.2e-26 93.2 0.0 1.1 1 0 0 1 1 1 1 Transthyretin-like family RhoGAP PF00620.27 VDM92347.1 - 5.2e-41 140.0 0.0 8.2e-41 139.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 VDM92347.1 - 3.4e-06 26.9 6.5 6.2e-06 26.0 6.5 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 VDM92347.1 - 0.081 13.1 3.6 0.068 13.3 1.7 1.9 2 0 0 2 2 2 0 KIAA1045 RING finger PHD PF00628.29 VDM92347.1 - 0.23 11.4 5.2 0.52 10.2 5.2 1.6 1 0 0 1 1 1 0 PHD-finger zf-C5HC2 PF02928.16 VDM92347.1 - 0.28 11.6 4.7 0.6 10.5 4.7 1.6 1 0 0 1 1 1 0 C5HC2 zinc finger zf-C2H2_3 PF13878.6 VDM92347.1 - 1.2 9.0 5.0 0.38 10.6 0.5 2.4 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO Prok-RING_1 PF14446.6 VDM92347.1 - 1.3 9.1 4.5 3 7.8 4.5 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 VDM92347.1 - 1.8 9.0 6.7 4.2 7.8 6.7 1.6 1 0 0 1 1 1 0 RING-like domain Solute_trans_a PF03619.16 VDM92350.1 - 4.5e-15 55.9 12.1 5.2e-15 55.7 12.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha HRG PF16954.5 VDM92350.1 - 3.7 8.0 11.8 6.6 7.2 6.9 3.5 2 2 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene LRR_4 PF12799.7 VDM92351.1 - 0.0087 16.5 0.1 0.026 14.9 0.1 1.8 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) TPM_phosphatase PF04536.14 VDM92351.1 - 0.02 15.1 0.0 0.026 14.7 0.0 1.1 1 0 0 1 1 1 0 TPM domain LRR_8 PF13855.6 VDM92351.1 - 0.023 14.5 0.1 0.037 13.8 0.1 1.3 1 0 0 1 1 1 0 Leucine rich repeat Annexin PF00191.20 VDM92353.1 - 1.6e-37 127.4 11.6 8.1e-14 51.4 0.2 4.2 3 1 1 4 4 4 4 Annexin GGA_N-GAT PF18308.1 VDM92353.1 - 0.049 13.3 1.2 0.08 12.6 0.3 1.9 2 0 0 2 2 2 0 GGA N-GAT domain DUF3447 PF11929.8 VDM92353.1 - 0.049 13.6 0.4 0.18 11.8 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3447) DNA_ligase_A_N PF04675.14 VDM92353.1 - 0.12 12.7 5.0 0.073 13.4 2.2 1.9 2 1 0 2 2 2 0 DNA ligase N terminus DUF4259 PF14078.6 VDM92353.1 - 0.14 12.9 0.2 0.83 10.4 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4259) MG2 PF01835.19 VDM92355.1 - 4e-17 62.5 0.1 2e-16 60.2 0.0 2.3 3 0 0 3 3 3 1 MG2 domain MG4 PF17789.1 VDM92355.1 - 1.3e-06 28.5 3.6 0.0021 18.2 0.1 3.6 3 1 0 3 3 3 2 Macroglobulin domain MG4 Glutaredoxin PF00462.24 VDM92356.1 - 3.1e-12 46.5 0.0 4.4e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 VDM92356.1 - 0.032 14.3 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_2 PF13098.6 VDM92356.1 - 0.14 12.7 0.0 0.23 11.9 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin-like domain Glyco_transf_20 PF00982.21 VDM92358.1 - 7.8e-25 87.5 3.9 2.1e-23 82.7 3.9 2.2 1 1 0 1 1 1 1 Glycosyltransferase family 20 Sybindin PF04099.12 VDM92358.1 - 0.13 12.2 0.1 0.78 9.7 0.1 2.1 2 0 0 2 2 2 0 Sybindin-like family Ion_trans_2 PF07885.16 VDM92359.1 - 4.6e-34 116.2 15.6 5e-17 61.6 1.0 2.2 2 0 0 2 2 2 2 Ion channel Ion_trans PF00520.31 VDM92359.1 - 2.8e-05 23.5 3.7 0.0016 17.7 0.3 2.2 2 0 0 2 2 2 2 Ion transport protein DUF3094 PF11293.8 VDM92359.1 - 0.1 12.4 1.8 2.6 7.8 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) DUF2157 PF09925.9 VDM92359.1 - 0.26 11.1 4.3 0.09 12.6 0.5 2.3 2 2 1 3 3 3 0 Predicted membrane protein (DUF2157) PAN_1 PF00024.26 VDM92362.1 - 7e-18 64.4 14.4 1.1e-11 44.5 3.9 2.9 2 0 0 2 2 2 2 PAN domain TSP_1 PF00090.19 VDM92362.1 - 0.0074 16.5 5.6 0.03 14.5 5.6 2.1 1 0 0 1 1 1 1 Thrombospondin type 1 domain Preseq_ALAS PF09029.10 VDM92362.1 - 1.2 9.6 6.2 0.58 10.6 1.6 2.8 1 1 1 2 2 2 0 5-aminolevulinate synthase presequence EF-hand_2 PF09068.11 VDM92367.1 - 1.2e-34 119.1 1.1 1.4e-34 118.9 1.1 1.0 1 0 0 1 1 1 1 EF hand NADH_oxidored PF08040.11 VDM92367.1 - 0.053 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 MNLL subunit FeoB_N PF02421.18 VDM92371.1 - 0.13 11.8 0.2 0.15 11.6 0.2 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B Collagen PF01391.18 VDM92372.1 - 5.6e-19 67.7 65.9 2.2e-08 33.7 14.9 3.4 2 1 1 3 3 3 3 Collagen triple helix repeat (20 copies) Endostatin PF06482.11 VDM92372.1 - 4.9e-05 23.0 0.0 6.2e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Collagenase NC10 and Endostatin MBOAT PF03062.19 VDM92380.1 - 6.6e-22 78.3 15.9 8.7e-22 77.9 15.9 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family START PF01852.19 VDM92388.1 - 7.4e-11 41.9 0.7 8.5e-11 41.7 0.7 1.0 1 0 0 1 1 1 1 START domain Collagen PF01391.18 VDM92391.1 - 1.2e-06 28.1 19.7 1.5e-06 27.8 19.7 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Collagen PF01391.18 VDM92392.1 - 6.8e-09 35.4 22.8 9.4e-09 34.9 22.8 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Collagen PF01391.18 VDM92393.1 - 0.043 13.6 1.8 0.074 12.8 1.8 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) zf-C2H2 PF00096.26 VDM92395.1 - 0.043 14.3 7.0 0.65 10.6 1.2 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDM92395.1 - 0.7 10.9 6.5 3.8 8.6 1.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Pkinase PF00069.25 VDM92399.1 - 2.3e-46 158.3 0.0 1.1e-42 146.2 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain C1_1 PF00130.22 VDM92399.1 - 4.6e-31 106.5 30.7 2.3e-15 56.2 11.8 2.9 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_Tyr PF07714.17 VDM92399.1 - 7.2e-24 84.5 0.0 1.8e-23 83.1 0.0 1.6 1 1 1 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 VDM92399.1 - 2.7e-05 23.3 0.3 3.8e-05 22.8 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Zf_RING PF16744.5 VDM92399.1 - 0.011 15.9 13.9 0.58 10.3 3.8 2.7 2 0 0 2 2 2 0 KIAA1045 RING finger Kdo PF06293.14 VDM92399.1 - 0.012 14.9 0.2 0.02 14.3 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 VDM92399.1 - 0.013 14.8 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 VDM92399.1 - 0.019 14.9 0.4 0.17 11.8 0.3 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 VDM92399.1 - 0.042 13.5 0.3 6.7 6.3 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 CadC_C1 PF18500.1 VDM92399.1 - 0.11 12.6 0.0 0.35 11.0 0.0 1.8 1 0 0 1 1 1 0 CadC C-terminal domain 1 Pkinase_fungal PF17667.1 VDM92399.1 - 0.14 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 VDM92399.1 - 0.18 11.4 0.1 0.31 10.6 0.1 1.3 1 0 0 1 1 1 0 RIO1 family Act-Frag_cataly PF09192.10 VDM92399.1 - 0.38 10.1 1.3 0.71 9.2 0.1 1.8 2 0 0 2 2 2 0 Actin-fragmin kinase, catalytic PHD PF00628.29 VDM92399.1 - 5.3 7.0 25.6 1.9 8.4 9.0 2.9 2 0 0 2 2 2 0 PHD-finger VASt PF16016.5 VDM92403.1 - 6.1e-26 91.7 0.5 1.3e-25 90.6 0.5 1.6 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain Ribosomal_S7e PF01251.18 VDM92404.1 - 4e-66 222.3 5.3 4.9e-56 189.4 3.4 2.0 1 1 1 2 2 2 2 Ribosomal protein S7e DUF4834 PF16118.5 VDM92408.1 - 0.044 14.7 3.5 0.056 14.4 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SID-1_RNA_chan PF13965.6 VDM92408.1 - 1.1 7.6 4.6 1.1 7.6 4.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Striatin PF08232.12 VDM92408.1 - 1.3 9.6 5.0 1.4 9.5 5.0 1.0 1 0 0 1 1 1 0 Striatin family DEP PF00610.21 VDM92410.1 - 1e-06 28.7 0.0 2.4e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ADH_N PF08240.12 VDM92412.1 - 3.3e-24 84.9 1.4 3.3e-24 84.9 1.4 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 VDM92412.1 - 2.1e-21 76.3 0.1 5.6e-21 74.9 0.1 1.7 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 VDM92412.1 - 1.9e-05 25.7 0.0 3.3e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 VDM92412.1 - 0.0067 15.9 0.1 0.045 13.2 0.1 2.2 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus 2-Hacid_dh_C PF02826.19 VDM92412.1 - 0.0082 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 VDM92412.1 - 0.03 13.6 0.1 0.045 13.0 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Latexin PF06907.12 VDM92412.1 - 0.18 11.3 0.1 0.29 10.6 0.1 1.3 1 0 0 1 1 1 0 Latexin tRNA_U5-meth_tr PF05958.11 VDM92413.1 - 1.5e-06 27.5 0.0 1.7e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Metallophos PF00149.28 VDM92416.1 - 1.2e-12 48.8 0.0 1.7e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Connexin PF00029.19 VDM92417.1 - 0.12 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Connexin HCO3_cotransp PF00955.21 VDM92420.1 - 1.7e-73 248.2 9.8 8.2e-71 239.3 9.8 2.3 1 1 0 1 1 1 1 HCO3- transporter family Band_3_cyto PF07565.13 VDM92420.1 - 8.4e-53 179.9 0.0 2.2e-52 178.5 0.0 1.7 1 1 0 1 1 1 1 Band 3 cytoplasmic domain CPSase_L_D2 PF02786.17 VDM92422.1 - 1.2e-50 172.0 0.1 2e-50 171.2 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 VDM92422.1 - 2.6e-22 79.4 0.0 5.5e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 VDM92422.1 - 1.3e-07 31.7 0.0 2.6e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 VDM92422.1 - 0.00042 19.9 0.0 0.00093 18.8 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 VDM92422.1 - 0.0033 17.5 0.0 0.0062 16.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 VDM92422.1 - 0.0064 16.1 0.0 0.034 13.8 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_Ter PF15632.6 VDM92422.1 - 0.13 12.0 0.2 1.1 9.0 0.2 2.1 1 1 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon DUF2689 PF10894.8 VDM92426.1 - 0.12 12.1 0.0 11 5.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2689) An_peroxidase PF03098.15 VDM92428.1 - 9.4e-88 295.1 0.0 1.2e-87 294.8 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase Peroxin-22 PF12827.7 VDM92428.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family Rav1p_C PF12234.8 VDM92434.1 - 5e-66 223.5 12.0 4.1e-65 220.4 12.0 2.0 1 1 0 1 1 1 1 RAVE protein 1 C terminal LSDAT_euk PF18139.1 VDM92442.1 - 9.5e-99 330.1 0.0 1.1e-97 326.6 0.0 2.0 1 1 0 1 1 1 1 SLOG in TRPM LSDAT_prok PF18171.1 VDM92442.1 - 3.9e-18 65.4 0.0 6e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 SLOG in TRPM, prokaryote ShK PF01549.24 VDM92453.1 - 4.1e-08 33.6 11.8 1.1e-07 32.3 7.2 2.3 2 0 0 2 2 2 1 ShK domain-like BUD22 PF09073.10 VDM92453.1 - 0.0018 17.7 3.6 0.002 17.6 3.6 1.1 1 0 0 1 1 1 1 BUD22 Sigma70_ner PF04546.13 VDM92453.1 - 0.0039 17.1 3.9 0.0042 17.0 3.9 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region Pox_Ag35 PF03286.14 VDM92453.1 - 0.012 15.4 5.8 0.014 15.2 5.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Cwf_Cwc_15 PF04889.12 VDM92453.1 - 0.31 10.8 10.9 0.36 10.5 10.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 VDM92453.1 - 0.33 9.1 11.5 0.38 8.9 11.5 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 VDM92453.1 - 0.44 8.8 9.3 0.48 8.6 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 VDM92453.1 - 0.53 8.8 7.7 0.65 8.5 7.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Rhabdo_ncap PF00945.18 VDM92453.1 - 0.56 9.0 4.2 0.62 8.9 4.2 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Tom22 PF04281.13 VDM92453.1 - 0.69 9.7 7.4 1.1 9.0 7.4 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Utp14 PF04615.13 VDM92453.1 - 0.76 8.3 8.5 0.85 8.1 8.5 1.0 1 0 0 1 1 1 0 Utp14 protein FAM176 PF14851.6 VDM92453.1 - 1.4 8.5 11.4 2.6 7.7 11.4 1.3 1 0 0 1 1 1 0 FAM176 family CobT PF06213.12 VDM92453.1 - 1.5 8.1 11.3 2 7.8 11.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sporozoite_P67 PF05642.11 VDM92453.1 - 2.2 6.2 7.3 2.5 6.1 7.3 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 VDM92453.1 - 2.4 6.1 16.6 2.9 5.9 16.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4611 PF15387.6 VDM92453.1 - 2.7 8.3 12.9 2.2 8.6 11.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) TRAP_alpha PF03896.16 VDM92453.1 - 4.1 6.5 6.6 5.7 6.1 6.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2457 PF10446.9 VDM92453.1 - 4.7 6.2 21.6 6 5.9 21.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 VDM92453.1 - 6.2 6.1 15.1 7.9 5.8 15.1 1.1 1 0 0 1 1 1 0 SDA1 UCH PF00443.29 VDM92456.1 - 3.6e-05 23.4 0.4 0.79 9.2 0.0 5.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4330 PF14221.6 VDM92459.1 - 0.036 14.3 4.4 0.038 14.2 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) TMEM154 PF15102.6 VDM92459.1 - 0.07 13.0 1.8 0.078 12.9 1.8 1.1 1 0 0 1 1 1 0 TMEM154 protein family CENP-B_dimeris PF09026.10 VDM92464.1 - 8.9 6.8 11.4 6.9 7.1 5.6 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TPP_enzyme_C PF02775.21 VDM92468.1 - 0.067 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CCD PF07860.11 VDM92468.1 - 0.099 12.7 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 WisP family C-Terminal Region Nif11 PF07862.11 VDM92468.1 - 0.16 12.3 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 Nif11 domain PepSY_TM PF03929.16 VDM92469.1 - 0.0073 16.0 0.0 0.0093 15.7 0.0 1.1 1 0 0 1 1 1 1 PepSY-associated TM region MOLO1 PF17175.4 VDM92469.1 - 0.045 13.9 0.1 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 Modulator of levamisole receptor-1 Abhydrolase_9_N PF15420.6 VDM92469.1 - 0.055 13.5 0.0 0.099 12.6 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Chordopox_A13L PF05961.11 VDM92469.1 - 0.067 13.4 0.0 0.24 11.6 0.0 1.8 2 0 0 2 2 2 0 Chordopoxvirus A13L protein DUF4448 PF14610.6 VDM92469.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) GCP_C_terminal PF04130.13 VDM92471.1 - 8.6e-13 48.4 1.1 9.3e-13 48.3 1.1 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF1148 PF06618.11 VDM92471.1 - 0.073 13.2 0.3 0.11 12.6 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1148) Aminotran_1_2 PF00155.21 VDM92477.1 - 8.2e-38 130.5 0.0 1.1e-37 130.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 VDM92477.1 - 0.0098 15.2 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DUF3692 PF12469.8 VDM92477.1 - 0.18 12.0 0.0 0.47 10.7 0.0 1.7 1 0 0 1 1 1 0 CRISPR-associated protein Forkhead PF00250.18 VDM92481.1 - 4.3e-28 97.4 0.0 6.7e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain Mito_carr PF00153.27 VDM92486.1 - 1.9e-22 79.0 0.1 2.3e-22 78.7 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein DUF1743 PF08489.11 VDM92486.1 - 0.096 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1743) DnaJ PF00226.31 VDM92487.1 - 1.8e-27 95.2 3.3 2.7e-27 94.6 3.3 1.3 1 0 0 1 1 1 1 DnaJ domain MAM PF00629.23 VDM92489.1 - 1.9e-10 40.9 0.0 2.1e-10 40.7 0.0 1.0 1 0 0 1 1 1 1 MAM domain, meprin/A5/mu HAP1_N PF04849.13 VDM92496.1 - 5.7e-21 75.0 3.6 7.2e-21 74.7 3.6 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Gal-bind_lectin PF00337.22 VDM92498.1 - 2e-66 221.5 0.0 3.6e-34 117.2 0.0 2.0 2 0 0 2 2 2 2 Galactoside-binding lectin CLASP_N PF12348.8 VDM92501.1 - 5.2e-14 52.4 2.0 9.3e-13 48.3 0.4 2.6 2 0 0 2 2 2 2 CLASP N terminal VWA PF00092.28 VDM92504.1 - 1.9e-33 116.2 0.3 3.2e-33 115.4 0.3 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 VDM92504.1 - 9.9e-16 58.3 0.2 2.1e-15 57.3 0.2 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 VDM92504.1 - 0.00019 21.4 0.0 0.0003 20.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Zona_pellucida PF00100.23 VDM92504.1 - 0.00034 20.5 0.8 0.00055 19.8 0.8 1.3 1 0 0 1 1 1 1 Zona pellucida-like domain Asp PF00026.23 VDM92508.1 - 1.9e-13 50.6 0.0 1.5e-08 34.5 0.0 2.0 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 VDM92508.1 - 0.0049 17.1 0.4 0.075 13.3 0.4 2.3 1 1 0 2 2 2 1 Xylanase inhibitor N-terminal 7tm_1 PF00001.21 VDM92511.1 - 5.5e-19 68.5 3.0 7e-19 68.2 3.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Shisa PF13908.6 VDM92511.1 - 0.062 13.6 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator NB PF04159.13 VDM92511.1 - 0.093 12.8 1.0 0.17 11.9 0.6 1.6 1 1 0 1 1 1 0 NB glycoprotein DUF3377 PF11857.8 VDM92511.1 - 0.12 12.4 1.9 0.33 10.9 1.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Comm PF15957.5 VDM92511.1 - 0.19 12.1 1.8 0.34 11.3 1.8 1.8 1 1 0 1 1 1 0 Commissureless DC_STAMP PF07782.13 VDM92511.1 - 0.19 11.5 0.2 0.19 11.5 0.2 2.9 3 1 0 3 3 3 0 DC-STAMP-like protein LRR19-TM PF15176.6 VDM92511.1 - 0.22 11.5 0.5 0.61 10.1 0.0 1.9 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain HemY_N PF07219.13 VDM92511.1 - 1.6 8.9 3.6 19 5.5 0.5 2.2 2 0 0 2 2 2 0 HemY protein N-terminus Orf78 PF06024.12 VDM92511.1 - 2.7 8.3 7.5 21 5.5 3.1 2.2 1 1 1 2 2 2 0 Orf78 (ac78) CBS PF00571.28 VDM92516.1 - 3e-17 62.8 0.6 0.00068 20.0 0.0 4.3 4 0 0 4 4 4 4 CBS domain DUF5488 PF17590.2 VDM92516.1 - 0.079 12.7 0.6 3.8 7.3 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5488) PDZ PF00595.24 VDM92518.1 - 2e-18 66.5 1.1 1.2e-10 41.5 0.5 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 VDM92518.1 - 3e-07 30.2 0.2 0.0033 17.2 0.0 2.9 2 1 0 2 2 2 2 PDZ domain PDZ_2 PF13180.6 VDM92518.1 - 0.00017 21.9 0.1 0.035 14.4 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Helicase_C PF00271.31 VDM92519.1 - 2.3e-20 73.0 0.0 1.6e-19 70.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 VDM92519.1 - 4.1e-18 65.2 0.2 1.5e-17 63.4 0.0 2.0 2 0 0 2 2 2 1 Bromodomain SnAC PF14619.6 VDM92519.1 - 1.5e-08 35.1 4.4 1.5e-08 35.1 4.4 3.6 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex HDA2-3 PF11496.8 VDM92519.1 - 0.00048 19.4 1.9 0.001 18.3 0.1 2.3 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 CAF1A PF12253.8 VDM92519.1 - 0.011 15.9 6.1 0.011 15.9 6.1 2.5 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A Ephrin PF00812.17 VDM92522.1 - 1.4e-14 54.3 0.0 2.2e-14 53.6 0.0 1.3 1 0 0 1 1 1 1 Ephrin PH PF00169.29 VDM92525.1 - 0.00071 20.1 0.0 0.0011 19.4 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 VDM92525.1 - 0.001 19.4 0.1 0.0018 18.7 0.1 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain Glyco_hydr_116N PF12215.8 VDM92527.1 - 5.6e-18 65.5 0.1 8.2e-18 64.9 0.1 1.2 1 1 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term NfI_DNAbd_pre-N PF10524.9 VDM92528.1 - 1.9 8.4 5.3 0.5 10.3 1.4 1.9 2 0 0 2 2 2 0 Nuclear factor I protein pre-N-terminus Alpha_adaptinC2 PF02883.20 VDM92529.1 - 1.3e-17 64.1 0.2 2.4e-17 63.2 0.2 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Pkinase_Tyr PF07714.17 VDM92534.1 - 1.5e-86 289.9 0.0 2.4e-86 289.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDM92534.1 - 1.4e-49 168.9 0.0 1.8e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDM92534.1 - 0.005 16.9 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Pkinase_fungal PF17667.1 VDM92534.1 - 0.14 10.9 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase GDPD PF03009.17 VDM92537.1 - 3.4e-32 112.2 0.0 5.3e-32 111.6 0.0 1.3 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 VDM92537.1 - 0.016 15.6 0.3 0.05 14.1 0.1 2.0 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Glyco_transf_49 PF13896.6 VDM92540.1 - 1.9e-46 158.9 6.9 4.8e-46 157.6 6.9 1.6 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan Phage_NinH PF06322.11 VDM92540.1 - 0.05 13.5 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Phage NinH protein C2 PF00168.30 VDM92542.1 - 5.5e-05 23.4 0.1 0.058 13.7 0.0 2.4 2 1 0 2 2 2 2 C2 domain DUF551 PF04448.12 VDM92542.1 - 0.00078 20.3 0.0 0.0023 18.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF551) Sporozoite_P67 PF05642.11 VDM92544.1 - 0.16 10.0 0.9 0.19 9.7 0.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pou PF00157.17 VDM92547.1 - 1.4e-30 105.1 0.1 3.8e-30 103.7 0.0 1.8 2 0 0 2 2 2 1 Pou domain - N-terminal to homeobox domain Homeodomain PF00046.29 VDM92547.1 - 6.3e-17 61.2 2.7 1.2e-16 60.3 1.7 2.0 2 0 0 2 2 2 1 Homeodomain HTH_31 PF13560.6 VDM92547.1 - 0.00037 20.8 0.0 0.031 14.6 0.0 2.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_3 PF01381.22 VDM92547.1 - 0.083 13.0 0.1 23 5.2 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix Pkinase_Tyr PF07714.17 VDM92551.1 - 1.5e-86 289.9 0.0 2.4e-86 289.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 VDM92551.1 - 1.4e-49 168.9 0.0 1.8e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SH2 PF00017.24 VDM92551.1 - 0.005 16.9 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Pkinase_fungal PF17667.1 VDM92551.1 - 0.14 10.9 0.0 0.23 10.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase BTB_2 PF02214.22 VDM92553.1 - 3.6e-11 43.3 0.0 7.5e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain 7tm_1 PF00001.21 VDM92558.1 - 1.5e-13 50.7 14.5 1.9e-13 50.4 14.5 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srw PF10324.9 VDM92558.1 - 2.2e-11 43.6 14.4 4.8e-10 39.2 14.4 2.0 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw TMEM154 PF15102.6 VDM92558.1 - 0.064 13.2 0.2 0.12 12.3 0.2 1.4 1 0 0 1 1 1 0 TMEM154 protein family Metallophos PF00149.28 VDM92563.1 - 1e-25 91.4 0.3 1.5e-25 90.9 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 VDM92563.1 - 1.7e-10 41.0 0.8 2.2e-09 37.5 0.1 2.7 4 0 0 4 4 4 1 PPP5 TPR repeat region zf-C2H2 PF00096.26 VDM92564.1 - 6.1e-24 83.1 53.2 0.00021 21.6 3.8 7.4 7 0 0 7 7 7 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDM92564.1 - 1.2e-21 75.5 52.0 0.0009 19.9 1.5 7.3 7 0 0 7 7 7 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 VDM92564.1 - 4.8e-18 64.7 52.8 6e-07 29.6 0.3 7.9 8 0 0 8 8 7 5 Zinc-finger double domain zf-C2H2_11 PF16622.5 VDM92564.1 - 4.4e-06 26.3 27.8 0.54 10.1 0.5 6.5 6 0 0 6 6 6 4 zinc-finger C2H2-type zf_UBZ PF18439.1 VDM92564.1 - 0.0012 18.4 22.5 0.027 14.1 0.1 6.3 6 0 0 6 6 6 1 Ubiquitin-Binding Zinc Finger zf-C2H2_jaz PF12171.8 VDM92564.1 - 0.0017 18.6 32.4 0.21 11.9 0.1 6.8 7 0 0 7 7 7 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 VDM92564.1 - 0.0064 16.5 0.2 0.0064 16.5 0.2 8.1 8 1 0 8 8 8 3 C2H2-type zinc finger TerY_C PF15616.6 VDM92564.1 - 0.014 15.5 4.7 0.046 13.8 0.1 2.8 1 1 0 2 2 2 0 TerY-C metal binding domain zf-met PF12874.7 VDM92564.1 - 0.016 15.6 0.5 0.016 15.6 0.5 6.5 7 0 0 7 7 6 0 Zinc-finger of C2H2 type zf-CHCC PF10276.9 VDM92564.1 - 0.018 15.1 3.9 17 5.6 0.0 4.8 5 0 0 5 5 5 0 Zinc-finger domain zf-H2C2_5 PF13909.6 VDM92564.1 - 0.024 14.4 0.0 0.024 14.4 0.0 7.0 8 0 0 8 8 7 0 C2H2-type zinc-finger domain zinc_ribbon_15 PF17032.5 VDM92564.1 - 0.025 15.3 18.0 0.38 11.5 4.0 4.7 2 1 1 4 4 4 0 zinc-ribbon family zf_C2H2_ZHX PF18387.1 VDM92564.1 - 0.038 13.6 0.5 0.038 13.6 0.5 4.8 4 1 2 6 6 6 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2HC_2 PF13913.6 VDM92564.1 - 0.062 13.2 0.3 0.062 13.2 0.3 5.6 7 0 0 7 7 5 0 zinc-finger of a C2HC-type Zn-C2H2_12 PF18112.1 VDM92564.1 - 0.12 12.9 10.0 4 8.0 0.3 5.0 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain zinc_ribbon_9 PF14369.6 VDM92564.1 - 0.25 11.6 17.8 1.2 9.5 0.1 5.5 5 0 0 5 5 4 0 zinc-ribbon zf-RING_7 PF02591.15 VDM92564.1 - 0.63 10.3 11.5 11 6.2 0.1 5.4 5 0 0 5 5 5 0 C4-type zinc ribbon domain Rad50_zn_hook PF04423.14 VDM92564.1 - 3.4 7.6 14.1 8.1 6.4 0.3 4.4 4 0 0 4 4 4 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.10 VDM92564.1 - 6.7 6.9 30.2 0.35 11.0 2.2 5.8 4 1 2 6 6 6 0 Zinc ribbon domain Mito_fiss_reg PF05308.11 VDM92566.1 - 0.094 12.8 4.5 0.12 12.4 4.5 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator CAP_N PF01213.19 VDM92566.1 - 4.9 6.5 8.8 6.4 6.2 8.8 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Peptidase_M13_N PF05649.13 VDM92568.1 - 7.7e-45 154.2 1.0 9.2e-45 153.9 1.0 1.1 1 0 0 1 1 1 1 Peptidase family M13 LIM PF00412.22 VDM92577.1 - 3.5e-09 36.7 6.0 6.2e-09 35.9 6.0 1.4 1 0 0 1 1 1 1 LIM domain HTH_35 PF13693.6 VDM92577.1 - 0.037 14.1 0.1 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding zf-CRD PF17979.1 VDM92577.1 - 2 8.5 7.3 22 5.1 3.9 2.4 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions PriC PF07445.12 VDM92580.1 - 0.015 15.3 0.2 0.016 15.1 0.2 1.1 1 0 0 1 1 1 0 Primosomal replication protein priC DUF2145 PF09916.9 VDM92580.1 - 0.062 12.9 0.1 0.07 12.8 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2145) Mucin PF01456.17 VDM92582.1 - 7.6 6.5 15.5 8.5 6.4 15.5 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein PQQ_2 PF13360.6 VDM92584.1 - 4.8e-10 39.4 0.6 9.5e-10 38.5 0.6 1.5 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 VDM92584.1 - 2.1e-07 30.5 0.1 0.021 14.7 0.1 3.3 3 0 0 3 3 3 3 PQQ enzyme repeat Actin PF00022.19 VDM92585.1 - 5.7e-85 285.4 0.0 2.3e-84 283.4 0.0 1.8 1 1 0 1 1 1 1 Actin Ribosomal_S13 PF00416.22 VDM92585.1 - 1.4e-53 180.7 1.0 2.3e-53 180.0 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S13/S18 7tm_1 PF00001.21 VDM92588.1 - 2.4e-05 23.8 0.1 3.1e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDM92588.1 - 0.002 17.6 0.1 0.0024 17.3 0.1 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx AnfO_nitrog PF09582.10 VDM92591.1 - 0.18 11.1 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) OrfB_Zn_ribbon PF07282.11 VDM92591.1 - 0.63 10.0 3.7 2.1 8.3 2.4 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Ion_trans_2 PF07885.16 VDM92594.1 - 9.6e-16 57.5 3.7 9.6e-16 57.5 3.7 3.1 4 0 0 4 4 4 1 Ion channel Ion_trans PF00520.31 VDM92594.1 - 9.7e-07 28.3 0.8 0.00075 18.8 0.0 2.2 1 1 0 2 2 2 2 Ion transport protein IRK PF01007.20 VDM92594.1 - 0.091 12.6 0.8 0.23 11.3 0.1 2.0 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain GnRH PF00446.17 VDM92594.1 - 0.22 12.0 1.1 0.6 10.6 1.1 1.7 1 0 0 1 1 1 0 Gonadotropin-releasing hormone RRM_1 PF00076.22 VDM92597.1 - 2.9e-06 27.0 0.0 4.3e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CLN3 PF02487.17 VDM92597.1 - 0.011 14.9 0.1 0.013 14.5 0.1 1.0 1 0 0 1 1 1 0 CLN3 protein RRM_occluded PF16842.5 VDM92597.1 - 0.047 13.6 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 VDM92597.1 - 0.074 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif K_channel_TID PF07941.11 VDM92597.1 - 0.11 12.9 5.8 0.99 9.9 1.0 2.6 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Aa_trans PF01490.18 VDM92600.1 - 3.1e-34 118.4 25.3 5.2e-34 117.6 25.3 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Aa_trans PF01490.18 VDM92601.1 - 5.4e-09 35.2 0.1 5.5e-09 35.2 0.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Lectin_C PF00059.21 VDM92608.1 - 0.016 15.9 0.1 0.094 13.5 0.0 1.9 1 1 1 2 2 2 0 Lectin C-type domain DUF4950 PF16308.5 VDM92610.1 - 0.047 13.7 0.1 0.063 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4950) Drf_GBD PF06371.13 VDM92612.1 - 0.0062 16.1 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain SNAP-25 PF00835.19 VDM92616.1 - 0.088 13.1 0.5 0.35 11.2 0.5 2.0 1 0 0 1 1 1 0 SNAP-25 family PBP1_TM PF14812.6 VDM92623.1 - 6.1 7.3 8.1 0.72 10.3 3.7 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-CCCH PF00642.24 VDM92627.1 - 1.1e-07 31.5 3.5 1.1e-07 31.5 3.5 2.2 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 VDM92627.1 - 6e-07 29.3 5.5 1.7e-06 27.9 5.5 1.8 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 VDM92627.1 - 9.8e-07 28.4 3.6 2.6e-06 27.1 3.6 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 VDM92627.1 - 0.0079 16.6 0.9 0.021 15.3 0.9 1.8 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 VDM92627.1 - 0.02 15.6 0.2 0.046 14.4 0.2 1.6 1 0 0 1 1 1 0 Torus domain zf-H2C2_2 PF13465.6 VDM92629.1 - 1.2e-16 60.3 22.4 4.5e-09 36.3 1.5 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 VDM92629.1 - 2.5e-11 43.4 20.4 0.00015 22.0 2.2 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 VDM92629.1 - 1.5e-06 28.5 19.4 0.017 15.9 1.9 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 VDM92629.1 - 2.1e-05 24.4 17.2 0.00024 21.0 1.4 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 VDM92629.1 - 5.6e-05 23.3 10.8 0.026 14.8 1.2 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 VDM92629.1 - 0.00084 19.2 5.7 0.074 13.0 0.6 2.6 2 0 0 2 2 2 2 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-met PF12874.7 VDM92629.1 - 0.012 16.0 10.2 0.53 10.7 0.9 3.9 3 1 0 3 3 3 0 Zinc-finger of C2H2 type Zn_ribbon_SprT PF17283.2 VDM92629.1 - 0.042 13.8 6.5 4 7.4 6.5 2.4 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zf-AN1 PF01428.16 VDM92629.1 - 0.055 13.6 12.5 1.2 9.3 2.2 3.3 3 0 0 3 3 3 0 AN1-like Zinc finger zf-C2H2_3rep PF18868.1 VDM92629.1 - 0.13 12.9 5.8 10 6.8 0.1 3.0 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2HC_2 PF13913.6 VDM92629.1 - 0.25 11.3 4.8 9.5 6.2 0.2 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type RdRP_5 PF07925.11 VDM92629.1 - 0.29 8.5 1.9 0.36 8.2 1.9 1.1 1 0 0 1 1 1 0 Reovirus RNA-dependent RNA polymerase lambda 3 zf-CRD PF17979.1 VDM92629.1 - 0.51 10.4 8.0 1.5 8.9 3.3 2.3 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions zf-CHY PF05495.12 VDM92629.1 - 0.78 10.3 13.0 1.5 9.4 8.3 2.3 1 1 1 2 2 2 0 CHY zinc finger zf-CHCC PF10276.9 VDM92629.1 - 1.1 9.3 12.3 1.4 9.0 1.6 3.2 3 0 0 3 3 3 0 Zinc-finger domain Elf1 PF05129.13 VDM92629.1 - 1.2 9.2 8.3 0.39 10.8 5.2 1.7 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like TEA PF01285.18 VDM92636.1 - 3.2e-07 30.3 0.0 4.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 TEA/ATTS domain CAP_N PF01213.19 VDM92637.1 - 1 8.7 4.5 1 8.8 4.5 1.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal LSM14 PF12701.7 VDM92644.1 - 6.1e-05 23.0 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain Formin_GBD_N PF18382.1 VDM92644.1 - 0.015 15.7 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 Formin N-terminal GTPase-binding domain SM-ATX PF14438.6 VDM92644.1 - 0.016 15.4 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 Ataxin 2 SM domain LSM PF01423.22 VDM92644.1 - 0.022 14.4 0.1 0.041 13.6 0.1 1.4 1 0 0 1 1 1 0 LSM domain DUF150_C PF17384.2 VDM92644.1 - 0.056 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 RimP C-terminal SH3 domain Med13_N PF11597.8 VDM92647.1 - 0.065 12.6 0.1 0.071 12.5 0.1 1.0 1 0 0 1 1 1 0 Mediator complex subunit 13 N-terminal Zn-ribbon_8 PF09723.10 VDM92647.1 - 0.12 12.5 0.6 0.25 11.5 0.6 1.6 1 0 0 1 1 1 0 Zinc ribbon domain CUB PF00431.20 VDM92655.1 - 1.7e-12 47.6 0.0 3.4e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 CUB domain Kelch_4 PF13418.6 VDM92655.1 - 4.2e-11 42.7 6.2 3e-05 23.9 0.3 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 VDM92655.1 - 1.8e-08 34.2 10.8 4.3e-06 26.6 0.0 4.0 5 0 0 5 5 5 2 Kelch motif EGF_2 PF07974.13 VDM92655.1 - 3e-08 33.9 48.2 0.00092 19.5 14.2 3.5 3 0 0 3 3 3 3 EGF-like domain Kelch_1 PF01344.25 VDM92655.1 - 3.5e-07 29.7 5.1 0.019 14.5 0.3 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 VDM92655.1 - 7.8e-07 29.2 2.7 0.01 16.1 0.0 3.2 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 VDM92655.1 - 2.8e-06 27.1 0.3 0.011 15.6 0.0 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 VDM92655.1 - 5.2e-06 26.6 4.8 0.0025 18.0 0.0 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain FBA_3 PF08268.12 VDM92655.1 - 0.044 13.7 0.0 0.38 10.7 0.0 2.2 2 0 0 2 2 2 0 F-box associated domain Laminin_EGF PF00053.24 VDM92655.1 - 0.25 11.5 46.5 0.43 10.8 10.4 3.4 2 1 1 3 3 3 0 Laminin EGF domain NUC153 PF08159.12 VDM92660.1 - 1.9e-10 40.4 0.1 3.5e-10 39.5 0.1 1.4 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 VDM92660.1 - 0.00011 22.9 0.6 0.079 13.9 0.1 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Ephrin PF00812.17 VDM92660.1 - 0.035 14.1 0.1 0.58 10.2 0.0 2.4 2 1 0 2 2 2 0 Ephrin Tom37 PF10568.9 VDM92660.1 - 0.16 12.3 0.0 0.33 11.3 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein TPR_2 PF07719.17 VDM92662.1 - 1.4e-21 74.7 11.7 0.00028 20.8 0.1 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 VDM92662.1 - 9.6e-14 50.5 18.9 0.0038 17.0 0.6 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 VDM92662.1 - 1.1e-12 47.1 19.4 0.001 19.1 0.2 7.1 6 1 2 8 8 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 VDM92662.1 - 1.2e-12 47.9 20.7 8.6e-05 22.8 1.8 6.5 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 VDM92662.1 - 2.9e-10 40.6 7.0 0.0023 18.5 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 VDM92662.1 - 5.3e-08 32.4 14.1 7.5e-05 22.3 0.1 5.8 5 1 1 6 6 6 2 TPR repeat TPR_14 PF13428.6 VDM92662.1 - 7.3e-08 32.6 9.0 1.6 9.8 0.0 6.8 5 1 3 8 8 8 1 Tetratricopeptide repeat TPR_7 PF13176.6 VDM92662.1 - 1.3e-07 31.1 7.7 0.57 10.3 0.1 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 VDM92662.1 - 9e-07 29.3 15.9 0.0024 18.4 0.7 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 VDM92662.1 - 2.5e-05 24.0 13.7 0.4 10.6 0.1 6.2 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 VDM92662.1 - 0.00021 21.3 6.0 3 8.1 0.0 5.4 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 VDM92662.1 - 0.00031 20.9 6.0 0.029 14.8 0.1 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 VDM92662.1 - 0.00032 20.7 0.8 0.0085 16.1 0.8 3.0 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat RPN7 PF10602.9 VDM92662.1 - 0.002 17.9 7.3 0.13 11.9 0.3 3.8 3 1 1 4 4 4 1 26S proteasome subunit RPN7 ANAPC3 PF12895.7 VDM92662.1 - 0.0021 18.2 16.5 0.18 12.1 0.2 4.8 4 2 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 VDM92662.1 - 0.0074 16.8 9.2 11 7.0 0.3 5.9 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 VDM92662.1 - 0.016 14.9 3.5 2.9 7.6 0.0 3.4 2 2 0 3 3 3 0 Tetratricopeptide repeat-like domain MIT PF04212.18 VDM92662.1 - 0.027 14.6 3.1 21 5.3 0.0 4.1 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain DUF3261 PF11659.8 VDM92662.1 - 0.043 13.7 0.1 0.079 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3261) ATP13 PF12921.7 VDM92662.1 - 0.077 12.9 0.5 0.73 9.7 0.2 2.6 2 0 0 2 2 2 0 Mitochondrial ATPase expression TPR_4 PF07721.14 VDM92662.1 - 0.49 11.2 4.0 4.1 8.3 0.1 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF5520 PF17658.1 VDM92670.1 - 0.16 11.1 0.1 0.21 10.7 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5520) PEP-utilizers PF00391.23 VDM92671.1 - 0.077 12.7 0.1 0.26 11.1 0.0 1.8 2 0 0 2 2 2 0 PEP-utilising enzyme, mobile domain LBP_BPI_CETP_C PF02886.17 VDM92673.1 - 3.8e-19 69.1 0.0 7.2e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 VDM92673.1 - 1.5e-09 37.7 0.3 2.3e-09 37.1 0.3 1.2 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain ABC2_membrane PF01061.24 VDM92676.1 - 5.9e-35 120.6 23.3 5.9e-35 120.6 23.3 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 VDM92676.1 - 1.7e-07 31.8 0.0 2.8e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 VDM92676.1 - 0.014 14.6 21.0 0.021 14.0 21.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Carb_anhydrase PF00194.21 VDM92679.1 - 4.1e-60 203.5 0.0 4.9e-60 203.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic-type carbonic anhydrase RGS PF00615.19 VDM92681.1 - 1.4e-36 125.3 2.0 2.4e-36 124.5 2.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain APC_u15 PF16636.5 VDM92681.1 - 0.06 13.8 3.8 0.12 12.9 0.4 3.2 3 0 0 3 3 3 0 Unstructured region on APC between APC_crr regions 5 and 6 DUF2722 PF10846.8 VDM92682.1 - 0.0001 21.4 9.9 0.00012 21.2 9.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Spt20 PF12090.8 VDM92682.1 - 0.0011 18.7 19.6 0.0015 18.2 19.6 1.3 1 0 0 1 1 1 1 Spt20 family MMR1 PF08505.10 VDM92682.1 - 0.017 15.5 11.8 0.026 14.8 11.8 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TERB2 PF15101.6 VDM92682.1 - 0.039 14.0 7.9 0.055 13.5 7.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Peptidase_S64 PF08192.11 VDM92682.1 - 0.054 12.0 4.0 0.056 11.9 4.0 1.1 1 0 0 1 1 1 0 Peptidase family S64 Presenilin PF01080.17 VDM92682.1 - 0.06 12.1 5.1 0.071 11.9 5.1 1.2 1 0 0 1 1 1 0 Presenilin UPF0560 PF10577.9 VDM92682.1 - 0.11 10.9 10.5 0.15 10.6 10.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Connexin PF00029.19 VDM92682.1 - 0.13 12.0 1.2 0.17 11.6 1.2 1.2 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 VDM92682.1 - 0.14 10.1 4.3 0.18 9.7 4.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EIIBC-GUT_N PF03612.14 VDM92682.1 - 0.17 11.6 1.9 0.28 10.9 1.9 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4407 PF14362.6 VDM92682.1 - 0.17 11.2 4.6 0.23 10.8 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SID-1_RNA_chan PF13965.6 VDM92682.1 - 0.22 9.9 0.2 0.25 9.7 0.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 VDM92682.1 - 0.32 11.0 2.5 0.44 10.6 2.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3464 PF11947.8 VDM92682.1 - 0.33 10.7 8.1 0.6 9.8 8.1 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 eIF-3_zeta PF05091.12 VDM92682.1 - 0.37 9.7 8.5 0.5 9.3 8.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Zip PF02535.22 VDM92682.1 - 0.45 9.7 2.4 0.55 9.4 2.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Plasmodium_Vir PF05795.11 VDM92682.1 - 0.48 9.8 4.4 0.59 9.5 4.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CLN3 PF02487.17 VDM92682.1 - 0.6 9.1 1.4 0.73 8.8 1.4 1.1 1 0 0 1 1 1 0 CLN3 protein Pex26 PF07163.12 VDM92682.1 - 0.66 9.2 7.3 0.94 8.7 7.3 1.2 1 0 0 1 1 1 0 Pex26 protein GREB1 PF15782.5 VDM92682.1 - 0.72 6.9 10.9 0.88 6.6 10.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Androgen_recep PF02166.16 VDM92682.1 - 1.2 7.9 19.5 1.4 7.7 18.8 1.5 2 0 0 2 2 2 0 Androgen receptor NAP PF00956.18 VDM92682.1 - 3 7.0 9.8 4.8 6.3 9.8 1.3 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) F-protein PF00469.20 VDM92682.1 - 3.6 7.1 10.9 4.6 6.8 10.3 1.5 1 1 0 1 1 1 0 Negative factor, (F-Protein) or Nef MscS_TM PF12794.7 VDM92682.1 - 8.9 5.1 5.6 13 4.6 5.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Hid1 PF12722.7 VDM92682.1 - 9.9 4.1 9.2 12 3.9 9.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein COMM_domain PF07258.14 VDM92683.1 - 4.4e-08 33.1 1.0 6e-08 32.7 0.3 1.6 2 0 0 2 2 2 1 COMM domain P53 PF00870.18 VDM92687.1 - 1.3e-43 149.1 0.1 1.7e-43 148.7 0.1 1.1 1 0 0 1 1 1 1 P53 DNA-binding domain CEP1-DNA_bind PF09287.10 VDM92687.1 - 0.00037 20.2 0.2 0.00096 18.8 0.2 1.6 1 1 0 1 1 1 1 CEP-1, DNA binding P53_tetramer PF07710.11 VDM92687.1 - 0.023 14.0 0.0 0.056 12.8 0.0 1.6 1 0 0 1 1 1 0 P53 tetramerisation motif McrBC PF10117.9 VDM92690.1 - 0.064 12.4 0.1 0.096 11.8 0.1 1.2 1 0 0 1 1 1 0 McrBC 5-methylcytosine restriction system component PNP_UDP_1 PF01048.20 VDM92695.1 - 1e-47 162.4 0.1 1.2e-47 162.2 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily MyTH4 PF00784.17 VDM92703.1 - 2.8e-25 88.9 0.0 6.4e-25 87.7 0.0 1.6 1 0 0 1 1 1 1 MyTH4 domain FERM_M PF00373.18 VDM92703.1 - 1.1e-07 32.3 0.0 2.1e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 FERM central domain RA PF00788.23 VDM92703.1 - 0.00017 22.1 0.4 0.00043 20.9 0.4 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain DUF4407 PF14362.6 VDM92707.1 - 0.7 9.2 8.6 0.82 9.0 8.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_M24 PF00557.24 VDM92710.1 - 8.5e-35 120.3 0.0 9.9e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 VDM92711.1 - 1.6e-23 82.7 0.0 2e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Phage_capsid PF05065.13 VDM92713.1 - 0.14 11.4 0.6 0.23 10.7 0.6 1.3 1 0 0 1 1 1 0 Phage capsid family MnhB PF04039.13 VDM92713.1 - 0.28 11.5 4.4 0.54 10.6 4.4 1.4 1 0 0 1 1 1 0 Domain related to MnhB subunit of Na+/H+ antiporter DUF3439 PF11921.8 VDM92713.1 - 0.32 11.0 6.4 0.66 9.9 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) LIP PF03583.14 VDM92713.1 - 0.68 9.2 2.7 3.9 6.7 1.4 2.1 2 0 0 2 2 2 0 Secretory lipase Sec6 PF06046.13 VDM92716.1 - 7.7e-15 54.3 3.6 1.2e-13 50.4 1.3 2.5 2 1 0 2 2 2 2 Exocyst complex component Sec6 Ribonuclease_T2 PF00445.18 VDM92716.1 - 0.13 12.5 0.3 0.94 9.7 0.0 2.3 2 0 0 2 2 2 0 Ribonuclease T2 family Wzy_C PF04932.15 VDM92718.1 - 0.00096 18.8 0.0 0.001 18.7 0.0 1.1 1 0 0 1 1 1 1 O-Antigen ligase CBP_BcsG PF11658.8 VDM92718.1 - 0.041 12.3 3.2 0.046 12.1 3.2 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Amnionless PF14828.6 VDM92718.1 - 0.24 10.2 0.3 0.26 10.1 0.3 1.1 1 0 0 1 1 1 0 Amnionless TraG_N PF07916.11 VDM92718.1 - 1 8.1 27.5 1.2 7.9 27.5 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region RRN3 PF05327.11 VDM92718.1 - 8.7 4.8 7.2 9.1 4.7 7.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Gal_Lectin PF02140.18 VDM92722.1 - 1.6e-28 98.9 8.2 2.4e-16 59.9 1.0 2.2 2 0 0 2 2 2 2 Galactose binding lectin domain Ricin_B_lectin PF00652.22 VDM92724.1 - 3.5e-19 69.3 0.1 5.1e-19 68.8 0.1 1.2 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Glyco_transf_7C PF02709.14 VDM92724.1 - 5.8e-08 32.3 0.1 1.4e-07 31.1 0.1 1.7 1 0 0 1 1 1 1 N-terminal domain of galactosyltransferase CDtoxinA PF03498.14 VDM92724.1 - 0.027 14.0 0.2 0.27 10.8 0.0 2.4 2 1 1 3 3 3 0 Cytolethal distending toxin A/C domain Glyco_tranf_2_3 PF13641.6 VDM92724.1 - 0.07 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 NOA36 PF06524.12 VDM92726.1 - 0.0001 21.7 3.0 0.00014 21.4 3.0 1.2 1 0 0 1 1 1 1 NOA36 protein Cwf_Cwc_15 PF04889.12 VDM92726.1 - 0.0044 16.8 3.0 0.0064 16.3 3.0 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Nucleo_P87 PF07267.11 VDM92726.1 - 0.012 14.6 0.4 0.014 14.3 0.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 K_channel_TID PF07941.11 VDM92726.1 - 0.015 15.7 21.4 0.058 13.8 5.0 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Imm5 PF14423.6 VDM92726.1 - 0.11 12.7 3.8 0.19 12.0 3.8 1.3 1 0 0 1 1 1 0 Immunity protein Imm5 NLBH PF05211.12 VDM92726.1 - 0.12 12.0 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Neuraminyllactose-binding hemagglutinin precursor (NLBH) DUF3824 PF12868.7 VDM92726.1 - 0.14 12.9 10.6 1.6 9.4 3.8 2.2 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) RXT2_N PF08595.11 VDM92726.1 - 0.15 12.1 1.1 0.19 11.8 1.1 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal CDC45 PF02724.14 VDM92726.1 - 0.17 10.2 1.2 0.2 9.9 1.2 1.1 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 VDM92726.1 - 0.19 12.1 9.8 0.3 11.5 9.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RskA PF10099.9 VDM92726.1 - 0.58 10.4 8.5 1.7 8.9 8.7 1.7 1 1 0 1 1 1 0 Anti-sigma-K factor rskA PGA2 PF07543.12 VDM92726.1 - 0.8 9.7 6.7 0.079 12.9 1.9 1.7 2 0 0 2 2 2 0 Protein trafficking PGA2 DNA_pol_phi PF04931.13 VDM92726.1 - 1 7.3 6.1 1.2 7.1 6.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF3245 PF11595.8 VDM92726.1 - 2.5 8.6 15.0 37 4.8 15.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) Annexin PF00191.20 VDM92728.1 - 3.1e-22 78.4 0.0 6.2e-22 77.5 0.0 1.5 2 0 0 2 2 2 1 Annexin Ldh_1_C PF02866.18 VDM92730.1 - 2.5e-36 125.1 0.0 3.8e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 VDM92730.1 - 2.8e-21 76.1 0.5 6.9e-21 74.8 0.1 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain PE-PPE PF08237.11 VDM92730.1 - 0.0013 18.3 0.1 0.0021 17.6 0.1 1.2 1 0 0 1 1 1 1 PE-PPE domain PDZ PF00595.24 VDM92732.1 - 2.4e-08 34.2 0.0 2.8e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 VDM92732.1 - 3.6e-08 33.1 0.1 5e-08 32.7 0.1 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDM92732.1 - 0.0031 17.8 0.0 0.0037 17.6 0.0 1.2 1 0 0 1 1 1 1 PDZ domain DMP1 PF07263.11 VDM92736.1 - 6.2 5.6 5.5 2.9 6.7 0.9 1.9 1 1 1 2 2 2 0 Dentin matrix protein 1 (DMP1) Slu7 PF11708.8 VDM92744.1 - 2.3e-98 329.3 8.8 2.3e-98 329.3 8.8 2.2 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor DSBA PF01323.20 VDM92744.1 - 0.066 13.0 0.7 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 DSBA-like thioredoxin domain Pkinase PF00069.25 VDM92745.1 - 4.4e-27 95.1 0.0 5.5e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM92745.1 - 2.3e-10 40.2 0.0 3.1e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 VDM92745.1 - 0.0034 16.8 0.0 0.0042 16.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase PF00069.25 VDM92748.1 - 3.1e-63 213.6 0.0 3.9e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM92748.1 - 1.8e-27 96.3 0.0 2.6e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 VDM92748.1 - 0.0012 18.8 0.0 0.19 11.6 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 VDM92748.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family BRCT_3 PF18428.1 VDM92748.1 - 0.037 14.1 0.0 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Haspin_kinase PF12330.8 VDM92748.1 - 0.18 10.7 0.1 0.35 9.8 0.1 1.5 1 0 0 1 1 1 0 Haspin like kinase domain ABC_tran PF00005.27 VDM92749.1 - 1.4e-34 119.6 0.0 2.5e-34 118.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 VDM92749.1 - 3.1e-21 76.2 1.8 4.3e-21 75.8 1.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 VDM92749.1 - 1.4e-09 37.8 0.1 5.1e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 VDM92749.1 - 0.0011 18.6 0.4 0.0027 17.4 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.17 VDM92749.1 - 0.0029 17.7 0.3 0.0084 16.2 0.1 1.9 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 VDM92749.1 - 0.0056 17.0 0.1 0.024 14.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 VDM92749.1 - 0.0057 17.1 0.1 0.014 15.8 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 VDM92749.1 - 0.021 13.6 0.5 0.046 12.5 0.1 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_7 PF12775.7 VDM92749.1 - 0.051 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 VDM92749.1 - 0.062 13.0 0.1 0.93 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 VDM92749.1 - 0.069 12.4 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.14 VDM92749.1 - 0.11 12.5 0.0 0.33 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 VDM92749.1 - 0.12 12.8 0.1 0.29 11.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain Astacin PF01400.24 VDM92755.1 - 2.3e-28 99.1 0.0 3.5e-28 98.5 0.0 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) COX15-CtaA PF02628.15 VDM92762.1 - 1.6e-102 342.9 13.3 1.9e-102 342.7 13.3 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein HMG_box PF00505.19 VDM92764.1 - 8.3e-27 93.4 3.8 8.3e-27 93.4 3.8 2.0 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDM92764.1 - 3.8e-11 43.4 2.2 3.8e-11 43.4 2.2 2.2 2 0 0 2 2 2 1 HMG-box domain SOXp PF12336.8 VDM92764.1 - 0.041 14.9 14.3 0.17 12.9 10.6 3.4 2 1 0 2 2 2 0 SOX transcription factor DUF3761 PF12587.8 VDM92764.1 - 0.044 14.2 3.2 0.16 12.4 3.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) Spt20 PF12090.8 VDM92764.1 - 0.32 10.6 16.7 0.53 9.8 16.7 1.3 1 0 0 1 1 1 0 Spt20 family GHMP_kinases_N PF00288.26 VDM92764.1 - 0.44 10.8 7.0 4.6 7.5 0.4 3.9 4 0 0 4 4 4 0 GHMP kinases N terminal domain SUIM_assoc PF16619.5 VDM92764.1 - 1 9.5 16.7 0.093 12.8 10.7 2.5 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 VDM92764.1 - 1.1 9.2 24.5 4.9 7.0 24.6 1.8 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Plasmodium_Vir PF05795.11 VDM92764.1 - 2.1 7.7 5.2 3.9 6.8 5.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein gpUL132 PF11359.8 VDM92767.1 - 0.035 13.6 3.1 16 4.9 0.0 4.6 3 2 0 4 4 4 0 Glycoprotein UL132 DUF3614 PF12267.8 VDM92767.1 - 0.19 12.2 2.7 0.58 10.6 2.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3614) A2M_recep PF07677.14 VDM92768.1 - 0.004 17.8 0.9 0.0066 17.1 0.9 1.4 1 0 0 1 1 1 1 A-macroglobulin receptor binding domain PAN_1 PF00024.26 VDM92771.1 - 1.8e-13 50.2 2.1 1.8e-13 50.2 2.1 2.4 3 0 0 3 3 3 1 PAN domain nos_propeller PF18764.1 VDM92771.1 - 0.081 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Nitrous oxide reductase propeller repeat ELFV_dehydrog_N PF02812.18 VDM92776.1 - 7.5e-56 187.6 0.0 1.2e-55 186.9 0.0 1.3 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 VDM92776.1 - 6.9e-43 147.1 0.0 1.1e-42 146.5 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 VDM92776.1 - 0.12 9.8 0.0 0.18 9.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase DUF1461 PF07314.11 VDM92777.1 - 1.7 8.5 9.9 1.7 8.5 3.3 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1461) DUF2207 PF09972.9 VDM92777.1 - 2 7.1 5.7 2.4 6.8 5.0 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) APG5 PF04106.12 VDM92783.1 - 2.5e-42 145.0 2.3 6.1e-42 143.8 2.3 1.6 1 1 0 1 1 1 1 Autophagy protein Apg5 DUF5509 PF17625.2 VDM92783.1 - 0.025 13.7 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5509) Anoct_dimer PF16178.5 VDM92783.1 - 0.05 13.3 0.1 0.067 12.9 0.1 1.1 1 0 0 1 1 1 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin An_peroxidase PF03098.15 VDM92785.1 - 1.7e-49 168.8 0.8 2.4e-49 168.4 0.8 1.2 1 0 0 1 1 1 1 Animal haem peroxidase DNA_methylase PF00145.17 VDM92787.1 - 9e-14 51.5 0.0 2.2e-13 50.3 0.0 1.6 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase Presenilin PF01080.17 VDM92792.1 - 1.3e-53 182.2 8.9 1.6e-53 181.9 8.9 1.0 1 0 0 1 1 1 1 Presenilin DUF4728 PF15860.5 VDM92792.1 - 0.68 10.6 13.3 7.1 7.4 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4728) DUF202 PF02656.15 VDM92792.1 - 0.98 9.9 8.4 3 8.4 0.2 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF2070 PF09843.9 VDM92792.1 - 2.6 6.2 9.8 0.61 8.3 6.1 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF3852 PF12963.7 VDM92792.1 - 2.6 8.4 9.3 3.1 8.2 6.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3852) Peptidase_A17 PF05380.13 VDM92798.1 - 2.9e-21 76.1 0.6 2.9e-21 76.1 0.6 2.2 3 0 0 3 3 3 1 Pao retrotransposon peptidase DUF5641 PF18701.1 VDM92798.1 - 5.2e-05 23.3 0.1 0.00013 22.0 0.1 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5641) RT_RNaseH_2 PF17919.1 VDM92798.1 - 0.00068 19.6 0.1 0.0019 18.2 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 VDM92798.1 - 0.0035 17.6 0.1 0.012 15.8 0.2 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase DUF1840 PF08895.11 VDM92798.1 - 0.04 14.3 0.4 0.084 13.2 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DUF1758 PF05585.12 VDM92799.1 - 0.00012 21.9 0.0 0.00012 21.9 0.0 1.0 1 0 0 1 1 1 1 Putative peptidase (DUF1758) DUF1759 PF03564.15 VDM92800.1 - 1.4e-19 70.5 0.5 2e-19 70.0 0.1 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1759) Med21 PF11221.8 VDM92800.1 - 2.1 8.6 5.3 1.4 9.2 0.7 2.2 2 1 0 2 2 2 0 Subunit 21 of Mediator complex Lectin_C PF00059.21 VDM92804.1 - 8.1e-08 33.0 2.0 1.8e-07 31.9 2.0 1.5 1 0 0 1 1 1 1 Lectin C-type domain SH3_2 PF07653.17 VDM92805.1 - 4.6e-09 35.8 0.0 1.1e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 VDM92805.1 - 1.3e-07 31.3 0.0 2.6e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 VDM92805.1 - 5e-07 29.2 0.1 3.3e-06 26.6 0.1 2.3 1 1 0 1 1 1 1 SH3 domain UCH PF00443.29 VDM92808.1 - 7.8e-05 22.3 2.4 2.5 7.5 2.3 5.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase HTH_57 PF18679.1 VDM92808.1 - 3.4 8.0 10.2 72 3.8 0.1 5.3 4 0 0 4 4 4 0 ThcOx helix turn helix domain MIP PF00230.20 VDM92809.1 - 1.3e-37 129.7 5.4 1.5e-37 129.5 5.4 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF4514 PF14986.6 VDM92809.1 - 0.64 10.0 0.0 0.64 10.0 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4514) YfiO PF13525.6 VDM92812.1 - 0.004 16.9 0.5 0.011 15.5 0.1 1.8 2 0 0 2 2 2 1 Outer membrane lipoprotein TPR_8 PF13181.6 VDM92812.1 - 0.0062 16.7 4.1 0.019 15.2 0.1 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 VDM92812.1 - 0.011 15.9 1.0 0.018 15.3 1.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 VDM92812.1 - 0.014 15.5 5.7 0.72 10.1 0.2 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 VDM92812.1 - 0.021 14.6 0.4 0.021 14.6 0.4 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 VDM92812.1 - 0.027 15.1 4.9 3.6 8.4 0.2 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat RNR_Alpha PF17975.1 VDM92812.1 - 0.027 14.9 1.0 0.034 14.6 1.0 1.1 1 0 0 1 1 1 0 Ribonucleotide reductase alpha domain Sorb PF02208.16 VDM92812.1 - 0.13 12.1 0.2 0.25 11.2 0.2 1.5 1 0 0 1 1 1 0 Sorbin homologous domain Cation_ATPase_C PF00689.21 VDM92814.1 - 1.3e-43 148.9 7.1 1.3e-43 148.9 7.1 1.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 VDM92814.1 - 9.8e-13 48.9 0.0 2.2e-12 47.7 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 VDM92814.1 - 1.7e-07 31.3 1.0 3.5e-05 23.7 0.4 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase ATP_Ca_trans_C PF12424.8 VDM92814.1 - 1.6e-06 28.5 3.4 5.5e-06 26.8 3.4 2.0 1 0 0 1 1 1 1 Plasma membrane calcium transporter ATPase C terminal DUF916 PF06030.12 VDM92816.1 - 0.16 12.1 2.5 0.26 11.4 2.5 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) Ashwin PF15323.6 VDM92816.1 - 0.31 11.0 12.7 0.46 10.5 12.7 1.1 1 0 0 1 1 1 0 Developmental protein HIP1_clath_bdg PF16515.5 VDM92816.1 - 0.37 11.4 3.8 0.19 12.4 0.4 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 AAA PF00004.29 VDM92822.1 - 9.2e-09 35.8 0.7 0.0021 18.5 0.5 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 VDM92822.1 - 0.00028 20.3 0.2 0.26 10.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 VDM92822.1 - 0.00043 20.3 0.2 1.1 9.2 0.2 2.9 3 0 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 VDM92822.1 - 0.0013 19.2 0.1 0.26 11.7 0.1 2.7 3 0 0 3 3 3 1 AAA ATPase domain Rad17 PF03215.15 VDM92822.1 - 0.0066 16.4 0.4 5.2 7.0 0.0 2.7 2 1 1 3 3 3 2 Rad17 P-loop domain DUF815 PF05673.13 VDM92822.1 - 0.012 14.8 0.0 1.1 8.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 VDM92822.1 - 0.02 14.7 0.1 5.4 6.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 VDM92822.1 - 0.021 15.2 0.1 5.9 7.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 VDM92822.1 - 0.035 13.9 0.0 0.66 9.7 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 VDM92822.1 - 0.036 14.5 0.1 2.9 8.3 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ATPase PF06745.13 VDM92822.1 - 0.037 13.4 0.4 5.2 6.3 0.1 2.4 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.6 VDM92822.1 - 0.037 14.6 0.1 15 6.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain SRF-TF PF00319.18 VDM92822.1 - 0.045 13.2 0.1 0.14 11.6 0.1 1.8 1 0 0 1 1 1 0 SRF-type transcription factor (DNA-binding and dimerisation domain) NACHT PF05729.12 VDM92822.1 - 0.063 13.2 0.4 9.1 6.2 0.0 3.0 3 0 0 3 3 3 0 NACHT domain RHSP PF07999.11 VDM92822.1 - 0.084 11.7 0.0 3 6.5 0.0 2.2 2 0 0 2 2 2 0 Retrotransposon hot spot protein AAA_22 PF13401.6 VDM92822.1 - 0.094 13.0 3.7 1.3 9.3 0.1 3.6 4 1 1 5 5 5 0 AAA domain Sigma54_activat PF00158.26 VDM92822.1 - 0.18 11.5 0.0 9.4 5.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Hydrolase PF00702.26 VDM92827.1 - 8e-15 55.7 0.0 4.8e-13 49.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 VDM92827.1 - 0.012 16.1 0.0 0.025 15.0 0.0 1.5 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 VDM92827.1 - 0.024 14.4 0.0 4.1 7.0 0.0 2.1 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 VDM92828.1 - 1.3e-19 70.6 0.1 1.9e-19 70.1 0.1 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus SpoIIM PF01944.17 VDM92828.1 - 0.0056 16.7 4.1 0.0089 16.1 3.1 1.8 1 1 0 1 1 1 1 Stage II sporulation protein M NDUF_B12 PF08122.12 VDM92834.1 - 7.5e-09 35.5 1.7 1.4e-08 34.6 1.7 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family MobL PF18555.1 VDM92834.1 - 0.037 13.3 0.1 0.046 13.0 0.1 1.1 1 0 0 1 1 1 0 MobL relaxases NDUF_B12 PF08122.12 VDM92838.1 - 6.8e-09 35.6 0.9 1.2e-08 34.8 0.9 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family MobL PF18555.1 VDM92838.1 - 0.028 13.7 1.1 0.039 13.2 1.1 1.2 1 0 0 1 1 1 0 MobL relaxases SelP_N PF04592.14 VDM92838.1 - 0.038 13.4 0.5 0.073 12.5 0.1 1.5 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DnaJ_C PF01556.18 VDM92841.1 - 9.7e-28 97.1 0.0 2e-27 96.1 0.0 1.5 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 VDM92841.1 - 1e-25 89.6 5.5 1.9e-25 88.8 5.5 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 VDM92841.1 - 2.9e-10 40.4 13.9 9.1e-10 38.8 13.9 1.9 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 VDM92841.1 - 0.0098 15.8 11.9 0.079 12.9 2.0 3.0 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 VDM92841.1 - 0.022 14.9 11.1 0.022 14.9 11.1 3.7 4 0 0 4 4 4 0 Family of unknown function (DUF5351) DUF2318 PF10080.9 VDM92841.1 - 3.4 7.8 7.0 6.5 6.9 0.8 2.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) I-set PF07679.16 VDM92844.1 - 1.8e-24 85.6 0.3 1.6e-11 44.1 0.1 2.4 2 1 0 2 2 2 2 Immunoglobulin I-set domain Ig_3 PF13927.6 VDM92844.1 - 1.9e-21 76.5 2.5 8.6e-10 39.1 0.1 2.9 2 1 1 3 3 3 2 Immunoglobulin domain Ig_2 PF13895.6 VDM92844.1 - 1.1e-12 48.1 2.0 4.5e-06 26.9 0.2 2.6 2 2 0 2 2 2 2 Immunoglobulin domain ig PF00047.25 VDM92844.1 - 1.4e-12 47.6 0.6 9.7e-06 25.7 0.0 3.0 2 1 1 3 3 3 2 Immunoglobulin domain V-set PF07686.17 VDM92844.1 - 0.00011 22.3 0.3 0.47 10.6 0.0 3.3 2 2 1 3 3 3 2 Immunoglobulin V-set domain C2-set_2 PF08205.12 VDM92844.1 - 0.00024 21.1 0.4 0.045 13.8 0.0 3.0 2 1 1 3 3 3 1 CD80-like C2-set immunoglobulin domain C2-set PF05790.15 VDM92844.1 - 0.0044 17.2 0.3 1.1 9.4 0.2 3.1 2 1 0 2 2 2 1 Immunoglobulin C2-set domain An_peroxidase PF03098.15 VDM92846.1 - 4.9e-56 190.4 0.0 2.3e-44 151.9 0.0 2.2 2 0 0 2 2 2 2 Animal haem peroxidase BCMA-Tall_bind PF09257.10 VDM92846.1 - 2.5 8.3 5.0 15 5.8 0.8 3.0 3 0 0 3 3 3 0 BCMA, TALL-1 binding zf-C2H2 PF00096.26 VDM92851.1 - 1.1e-10 41.3 12.8 4.7e-05 23.6 0.2 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 VDM92851.1 - 1.7e-07 31.3 9.2 0.00022 21.5 0.4 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 VDM92851.1 - 3.1e-06 27.5 12.3 0.042 14.7 0.3 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 VDM92851.1 - 0.00018 21.8 8.2 0.069 13.6 0.3 3.2 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 VDM92851.1 - 0.00038 20.7 7.3 0.01 16.1 0.3 3.2 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-Sec23_Sec24 PF04810.15 VDM92851.1 - 0.0049 16.9 2.5 2.9 8.0 0.2 3.2 3 0 0 3 3 3 1 Sec23/Sec24 zinc finger BolA PF01722.18 VDM92851.1 - 0.006 16.8 0.4 0.017 15.4 0.4 1.8 1 1 0 1 1 1 1 BolA-like protein FYVE_2 PF02318.16 VDM92851.1 - 0.013 15.7 1.8 0.02 15.1 1.8 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger zf-MYST PF17772.1 VDM92851.1 - 0.068 12.8 2.2 2.5 7.8 0.1 3.0 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C2H2_6 PF13912.6 VDM92851.1 - 0.091 12.8 11.2 0.36 10.9 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger LIM PF00412.22 VDM92851.1 - 0.1 12.8 4.7 0.22 11.7 4.6 1.6 1 1 0 1 1 1 0 LIM domain BAF1_ABF1 PF04684.13 VDM92851.1 - 0.14 11.2 2.6 0.16 11.0 2.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2256 PF10013.9 VDM92851.1 - 0.34 11.1 2.2 7.7 6.7 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-trcl PF13451.6 VDM92851.1 - 0.39 10.7 5.5 0.68 9.9 0.2 2.7 3 0 0 3 3 3 0 Probable zinc-ribbon domain SAP130_C PF16014.5 VDM92851.1 - 0.47 9.5 20.3 0.61 9.1 20.3 1.0 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus zf-C2H2_3rep PF18868.1 VDM92851.1 - 0.54 10.9 5.6 5 7.8 1.0 2.8 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 VDM92851.1 - 0.62 10.2 3.7 1.8 8.8 1.3 2.4 1 1 1 2 2 2 0 Zinc ribbon domain zf_UBZ PF18439.1 VDM92851.1 - 0.7 9.5 4.8 2.8 7.6 0.0 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2_2 PF12756.7 VDM92851.1 - 1.2 9.5 6.7 1.6 9.1 0.6 2.7 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Cript PF10235.9 VDM92851.1 - 1.8 9.2 5.0 6.9 7.3 2.4 2.5 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT TFIIA PF03153.13 VDM92851.1 - 5.9 6.8 5.2 6.2 6.7 5.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-CCHC_2 PF13696.6 VDM92851.1 - 6.7 6.6 9.4 2.8 7.8 0.5 2.8 3 0 0 3 3 3 0 Zinc knuckle ENTH PF01417.20 VDM92852.1 - 5e-47 159.0 0.0 7.6e-47 158.5 0.0 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 VDM92852.1 - 6e-06 25.4 0.0 8.5e-06 24.9 0.0 1.2 1 0 0 1 1 1 1 ANTH domain Sushi PF00084.20 VDM92858.1 - 0.00018 22.1 0.8 0.00032 21.2 0.8 1.5 1 0 0 1 1 1 1 Sushi repeat (SCR repeat) C8 PF08742.11 VDM92858.1 - 0.091 13.2 0.6 0.38 11.2 0.1 2.2 2 0 0 2 2 2 0 C8 domain Lactamase_B PF00753.27 VDM92859.1 - 1.5e-14 54.5 0.3 2.8e-14 53.6 0.2 1.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 VDM92859.1 - 1.5e-05 24.7 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 VDM92859.1 - 0.0086 16.0 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain M20_dimer PF07687.14 VDM92859.1 - 0.029 14.3 0.1 0.044 13.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase dimerisation domain Ras PF00071.22 VDM92860.1 - 3.5e-57 192.5 0.4 3.9e-57 192.4 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 VDM92860.1 - 9.7e-22 77.4 0.0 1.4e-21 76.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 VDM92860.1 - 1e-09 38.1 0.1 1.2e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 VDM92860.1 - 6.1e-06 25.9 0.5 1.7e-05 24.4 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 VDM92860.1 - 8.8e-05 22.6 0.1 0.00013 22.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 VDM92860.1 - 0.0036 17.2 2.6 1.1 9.1 0.1 2.2 1 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 VDM92860.1 - 0.0036 16.5 0.1 0.88 8.7 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit LSDAT_euk PF18139.1 VDM92864.1 - 0.078 12.4 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 SLOG in TRPM ACP_PD PF04336.12 VDM92864.1 - 0.12 12.9 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase Sarcoglycan_1 PF04790.13 VDM92865.1 - 2.9e-34 118.6 0.0 3.3e-34 118.4 0.0 1.0 1 0 0 1 1 1 1 Sarcoglycan complex subunit protein Sugar_tr PF00083.24 VDM92867.1 - 0.024 13.5 0.0 0.027 13.3 0.0 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter Amidohydro_1 PF01979.20 VDM92870.1 - 3.2e-11 43.1 0.0 4.4e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 VDM92870.1 - 1.8e-06 27.7 0.0 2.3e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family HPS3_N PF14761.6 VDM92870.1 - 0.0035 16.9 0.0 0.0055 16.3 0.0 1.2 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 UPF0047 PF01894.17 VDM92870.1 - 0.075 13.2 0.0 0.15 12.2 0.0 1.7 1 1 0 1 1 1 0 Uncharacterised protein family UPF0047 EGF PF00008.27 VDM92874.1 - 2e-26 91.9 64.2 1.7e-09 37.8 11.1 4.6 5 0 0 5 5 5 4 EGF-like domain hEGF PF12661.7 VDM92874.1 - 3.8e-15 55.9 52.9 1.2e-06 28.9 7.1 5.7 6 0 0 6 6 6 4 Human growth factor-like EGF EGF_CA PF07645.15 VDM92874.1 - 1.3e-11 44.5 63.6 4.1e-05 23.7 10.1 4.6 3 2 1 4 4 4 3 Calcium-binding EGF domain EGF_2 PF07974.13 VDM92874.1 - 9.9e-09 35.4 65.6 0.0019 18.5 16.5 4.9 4 1 1 5 5 5 4 EGF-like domain EGF_3 PF12947.7 VDM92874.1 - 1.9e-08 34.3 50.9 0.0015 18.6 6.6 5.4 4 3 1 5 5 5 4 EGF domain cEGF PF12662.7 VDM92874.1 - 3.4e-06 26.9 11.2 0.00014 21.7 1.6 5.9 6 1 0 6 6 6 3 Complement Clr-like EGF-like FXa_inhibition PF14670.6 VDM92874.1 - 0.0001 22.5 52.7 0.2 12.0 12.2 4.8 3 1 1 4 4 4 4 Coagulation Factor Xa inhibitory site EGF_MSP1_1 PF12946.7 VDM92874.1 - 0.0026 17.8 7.3 0.0026 17.8 7.3 5.2 5 1 0 5 5 5 2 MSP1 EGF domain 1 Laminin_EGF PF00053.24 VDM92874.1 - 0.0057 16.8 52.4 1.2 9.3 6.0 5.0 3 2 1 4 4 4 2 Laminin EGF domain Plasmod_Pvs28 PF06247.11 VDM92874.1 - 3 8.2 49.4 1.1 9.7 6.3 4.5 4 0 0 4 4 4 0 Pvs28 EGF domain DMP1 PF07263.11 VDM92881.1 - 6.2 5.6 5.5 2.9 6.7 0.9 1.9 1 1 1 2 2 2 0 Dentin matrix protein 1 (DMP1) Astacin PF01400.24 VDM92882.1 - 1.4e-47 161.8 9.9 2e-41 141.8 0.4 2.7 2 1 1 3 3 3 2 Astacin (Peptidase family M12A) CUB PF00431.20 VDM92882.1 - 1.4e-07 31.8 0.3 2.9e-07 30.8 0.3 1.5 1 0 0 1 1 1 1 CUB domain Reprolysin_4 PF13583.6 VDM92882.1 - 0.0038 16.9 0.7 0.0075 15.9 0.1 1.7 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 VDM92882.1 - 0.077 12.9 1.1 0.23 11.4 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.24 VDM92882.1 - 0.096 12.5 0.5 0.096 12.5 0.5 2.5 2 1 1 3 3 3 0 Matrixin Reprolysin_3 PF13582.6 VDM92882.1 - 0.11 13.0 0.0 0.41 11.2 0.0 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M7 PF02031.16 VDM92882.1 - 0.2 11.8 4.0 0.25 11.5 1.1 2.2 2 1 1 3 3 3 0 Streptomyces extracellular neutral proteinase (M7) family Peptidase_M57 PF12388.8 VDM92882.1 - 0.51 9.9 3.9 1.9 8.1 0.1 2.5 3 0 0 3 3 3 0 Dual-action HEIGH metallo-peptidase DUF229 PF02995.17 VDM92884.1 - 6.3e-67 226.3 0.6 7.6e-67 226.0 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 VDM92884.1 - 2.1e-05 24.1 0.1 2.6e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Sulfatase Sushi PF00084.20 VDM92888.1 - 2.6e-28 98.4 17.6 4.5e-07 30.4 0.8 5.0 5 0 0 5 5 5 4 Sushi repeat (SCR repeat) EGF_CA PF07645.15 VDM92888.1 - 5e-17 61.8 26.3 4.1e-10 39.7 6.0 4.3 4 0 0 4 4 4 2 Calcium-binding EGF domain CUB PF00431.20 VDM92888.1 - 6.5e-14 52.2 0.0 3.3e-06 27.4 0.0 2.5 2 0 0 2 2 2 2 CUB domain FXa_inhibition PF14670.6 VDM92888.1 - 1.1e-09 38.4 27.0 1.5e-08 34.7 5.3 4.1 4 0 0 4 4 4 2 Coagulation Factor Xa inhibitory site HRM PF02793.22 VDM92888.1 - 2.8e-08 33.9 11.4 0.0035 17.6 0.3 4.9 3 1 1 4 4 4 3 Hormone receptor domain EGF_3 PF12947.7 VDM92888.1 - 0.00022 21.4 20.3 0.017 15.3 4.8 3.5 3 0 0 3 3 3 2 EGF domain EGF PF00008.27 VDM92888.1 - 0.0011 19.2 30.3 0.0015 18.8 4.6 4.4 5 0 0 5 5 5 2 EGF-like domain cEGF PF12662.7 VDM92888.1 - 0.0022 17.9 28.8 0.059 13.3 0.5 6.9 8 0 0 8 8 8 3 Complement Clr-like EGF-like hEGF PF12661.7 VDM92888.1 - 0.028 15.1 4.1 0.028 15.1 4.1 5.0 4 1 0 4 4 4 0 Human growth factor-like EGF Ank_2 PF12796.7 VDM92895.1 - 3.2e-19 69.3 9.0 7.3e-10 39.3 0.2 2.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDM92895.1 - 1.8e-10 41.1 2.8 0.00012 22.6 0.2 3.9 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 VDM92895.1 - 2.1e-09 37.4 1.1 0.12 12.9 0.0 4.1 3 1 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 VDM92895.1 - 7.3e-09 35.2 0.4 0.029 14.9 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 VDM92895.1 - 2.2e-08 34.2 2.3 9.6e-06 25.8 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DNA_pol_A PF00476.20 VDM92903.1 - 9.3e-18 64.4 0.0 1.1e-17 64.2 0.0 1.0 1 0 0 1 1 1 1 DNA polymerase family A Eapp_C PF10238.9 VDM92903.1 - 0.099 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF4277 PF14104.6 VDM92903.1 - 0.12 12.7 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4277) CYTL1 PF15153.6 VDM92909.1 - 0.089 12.7 0.2 0.36 10.8 0.1 2.0 2 0 0 2 2 2 0 Cytokine-like protein 1 VapB_antitoxin PF09957.9 VDM92914.1 - 0.003 17.4 0.3 0.013 15.4 0.3 2.1 1 1 0 1 1 1 1 Bacterial antitoxin of type II TA system, VapB Asp PF00026.23 VDM92919.1 - 6.8e-39 134.1 0.0 7.6e-39 134.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 VDM92919.1 - 0.00011 22.0 0.0 0.00013 21.7 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Endostatin PF06482.11 VDM92922.1 - 8.5e-70 235.7 0.2 1e-69 235.5 0.2 1.0 1 0 0 1 1 1 1 Collagenase NC10 and Endostatin DUF1554 PF07588.11 VDM92922.1 - 2.4e-05 24.1 0.5 0.00034 20.4 0.5 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1554) Zip PF02535.22 VDM92933.1 - 6.6e-14 51.9 15.0 7.8e-13 48.3 15.0 2.2 1 1 0 1 1 1 1 ZIP Zinc transporter PIRT PF15099.6 VDM92933.1 - 0.069 12.7 0.1 0.31 10.6 0.1 1.9 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family CbtA PF09490.10 VDM92933.1 - 4.5 7.0 14.1 7.2 6.3 4.5 2.3 1 1 1 2 2 2 0 Probable cobalt transporter subunit (CbtA) AMP-binding PF00501.28 VDM92935.1 - 2.3e-18 66.0 0.2 2.2e-17 62.8 0.2 1.9 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 VDM92935.1 - 5.2e-13 49.8 0.0 7.1e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Pterin_bind PF00809.22 VDM92937.1 - 0.11 12.1 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Pterin binding enzyme LCE PF14672.6 VDM92939.1 - 0.12 13.0 1.9 0.35 11.5 1.9 1.8 1 0 0 1 1 1 0 Late cornified envelope PL48 PF15903.5 VDM92941.1 - 0.032 13.2 1.3 0.037 13.0 1.3 1.0 1 0 0 1 1 1 0 Filopodia upregulated, FAM65 PDZ_2 PF13180.6 VDM92946.1 - 1.4e-12 47.8 0.7 0.00024 21.3 0.0 3.4 3 0 0 3 3 3 3 PDZ domain PDZ PF00595.24 VDM92946.1 - 8.3e-10 38.9 0.5 0.00012 22.4 0.0 3.4 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 VDM92946.1 - 1.1e-08 34.8 0.9 0.015 15.1 0.0 3.6 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 VDM92946.1 - 0.0027 17.6 1.1 3.2 7.8 0.0 3.7 4 0 0 4 4 4 1 Tricorn protease PDZ domain PDZ_4 PF17816.1 VDM92946.1 - 0.075 13.4 0.2 4.6 7.7 0.0 3.0 3 0 0 3 3 3 0 PDZ domain EF-hand_1 PF00036.32 VDM92949.1 - 2.7e-17 60.9 6.8 8.5e-09 34.4 2.4 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 VDM92949.1 - 4.1e-14 51.2 2.0 1.4e-06 27.7 0.1 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 VDM92949.1 - 3.1e-13 49.9 0.4 8.9e-13 48.5 0.2 1.8 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 VDM92949.1 - 3.8e-10 39.5 4.3 1.9e-09 37.2 0.4 2.6 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 VDM92949.1 - 1.8e-05 24.0 7.1 0.019 14.4 0.2 3.1 2 1 1 3 3 3 2 EF hand EF-hand_9 PF14658.6 VDM92949.1 - 4e-05 23.9 0.0 6.7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 VDM92949.1 - 0.0011 18.9 0.4 0.09 12.7 0.2 2.2 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDM92949.1 - 0.07 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 VDM92949.1 - 0.15 12.1 0.1 0.66 9.9 0.1 1.9 1 1 0 1 1 1 0 Tellurite resistance protein TerB MRI PF15325.6 VDM92949.1 - 8.2 7.6 7.5 3.1 8.9 2.0 2.3 1 1 1 2 2 2 0 Modulator of retrovirus infection Tropomyosin_1 PF12718.7 VDM92953.1 - 7.6e-11 42.3 18.1 8.4e-11 42.2 18.1 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 VDM92953.1 - 4e-07 29.7 17.9 4.4e-07 29.5 17.9 1.0 1 0 0 1 1 1 1 Tropomyosin CLZ PF16526.5 VDM92953.1 - 0.00032 21.0 10.9 0.00039 20.7 10.6 1.3 1 1 0 1 1 1 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HrpB7 PF09486.10 VDM92953.1 - 0.0043 17.5 9.8 0.0049 17.3 9.8 1.1 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) Laminin_II PF06009.12 VDM92953.1 - 0.038 14.0 7.9 0.043 13.8 7.9 1.2 1 0 0 1 1 1 0 Laminin Domain II DHR10 PF18595.1 VDM92953.1 - 0.13 12.4 16.5 0.23 11.5 16.5 1.4 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain Hormone_1 PF00103.20 VDM92953.1 - 0.17 11.6 6.0 0.18 11.5 6.0 1.1 1 0 0 1 1 1 0 Somatotropin hormone family Lebercilin PF15619.6 VDM92953.1 - 0.18 11.5 16.0 0.27 10.9 16.0 1.3 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 VDM92953.1 - 0.23 11.5 7.6 0.11 12.6 4.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3584 PF12128.8 VDM92953.1 - 0.29 8.6 12.7 0.3 8.6 12.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF3552 PF12072.8 VDM92953.1 - 0.4 10.1 17.7 0.6 9.5 17.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) NBP1 PF08537.10 VDM92953.1 - 0.48 9.8 11.2 0.52 9.7 11.2 1.0 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DUF724 PF05266.14 VDM92953.1 - 0.49 10.2 13.4 0.52 10.1 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF2408 PF10303.9 VDM92953.1 - 0.52 10.9 7.4 0.6 10.7 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) CCDC-167 PF15188.6 VDM92953.1 - 0.57 10.5 9.2 0.85 10.0 8.1 1.9 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 Uds1 PF15456.6 VDM92953.1 - 0.58 10.3 11.0 0.72 10.0 11.0 1.2 1 0 0 1 1 1 0 Up-regulated During Septation Phage_HK97_TLTM PF06120.11 VDM92953.1 - 0.66 9.1 11.2 0.49 9.5 10.1 1.3 1 1 0 1 1 1 0 Tail length tape measure protein BRE1 PF08647.11 VDM92953.1 - 0.73 9.9 18.0 0.84 9.7 18.0 1.1 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Flagellin_N PF00669.20 VDM92953.1 - 0.75 9.9 7.4 9.8 6.3 1.7 1.9 1 1 0 1 1 1 0 Bacterial flagellin N-terminal helical region Nup88 PF10168.9 VDM92953.1 - 0.97 7.2 11.1 1 7.1 11.1 1.0 1 0 0 1 1 1 0 Nuclear pore component Exonuc_VII_L PF02601.15 VDM92953.1 - 1.1 8.8 7.1 1.1 8.8 7.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit EMP24_GP25L PF01105.24 VDM92953.1 - 1.4 8.9 5.4 1.6 8.7 5.1 1.3 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF948 PF06103.11 VDM92953.1 - 1.4 9.2 6.2 1.4 9.2 5.3 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4446 PF14584.6 VDM92953.1 - 1.7 8.7 6.1 2.1 8.3 6.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) SNARE PF05739.19 VDM92953.1 - 2.3 8.3 5.2 3.8 7.6 0.4 2.4 1 1 2 3 3 3 0 SNARE domain Spc7 PF08317.11 VDM92953.1 - 2.5 6.9 14.9 2.7 6.8 14.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HAUS6_N PF14661.6 VDM92953.1 - 3 7.4 11.5 3.5 7.1 11.5 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus EMC3_TMCO1 PF01956.16 VDM92953.1 - 3.7 7.2 10.6 2.7 7.7 9.6 1.3 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Atg14 PF10186.9 VDM92953.1 - 4.1 6.4 10.0 4.5 6.3 10.0 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 VDM92953.1 - 4.7 6.5 10.3 5.3 6.3 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 VDM92953.1 - 5 6.3 9.4 4.9 6.3 9.4 1.0 1 0 0 1 1 1 0 TMPIT-like protein V_ATPase_I PF01496.19 VDM92953.1 - 5.1 4.9 8.8 5 4.9 8.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2951 PF11166.8 VDM92953.1 - 5.8 7.2 11.6 5.9 7.2 11.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) DUF5446 PF17522.2 VDM92953.1 - 5.9 7.1 11.3 8.4 6.6 3.9 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5446) LRR_8 PF13855.6 VDM92957.1 - 9.1e-11 41.4 6.7 4.5e-08 32.7 4.1 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 VDM92957.1 - 7.5e-08 32.6 11.6 0.00015 22.1 2.8 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 VDM92957.1 - 7.4e-05 22.8 8.1 2.6 8.9 0.0 4.8 4 1 0 4 4 4 2 Leucine Rich Repeat ING PF12998.7 VDM92957.1 - 0.1 13.2 0.3 0.48 11.0 0.2 2.2 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding LRR_6 PF13516.6 VDM92957.1 - 0.2 11.8 9.0 17 5.8 0.3 4.5 4 0 0 4 4 4 0 Leucine Rich repeat NOA36 PF06524.12 VDM92965.1 - 0.0076 15.6 14.4 0.0092 15.3 14.4 1.3 1 0 0 1 1 1 1 NOA36 protein CNDH2_C PF16858.5 VDM92965.1 - 0.0081 16.1 2.8 0.0088 15.9 2.8 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC27 PF09507.10 VDM92965.1 - 0.013 15.0 9.2 0.016 14.6 9.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FYDLN_acid PF09538.10 VDM92965.1 - 0.023 15.4 14.1 0.023 15.4 14.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF4484 PF14831.6 VDM92965.1 - 0.071 13.1 8.8 0.093 12.8 8.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) PPP4R2 PF09184.11 VDM92965.1 - 0.34 10.5 21.5 0.48 10.0 21.5 1.1 1 0 0 1 1 1 0 PPP4R2 DUF3295 PF11702.8 VDM92965.1 - 1.2 8.4 26.0 1.6 8.0 26.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) TFIIA PF03153.13 VDM92965.1 - 1.8 8.5 19.8 2.5 8.0 19.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 VDM92965.1 - 7.7 6.5 25.4 19 5.2 25.4 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) AMP-binding PF00501.28 VDM92969.1 - 9.7e-10 37.6 0.0 2.5e-09 36.2 0.0 1.6 1 1 0 1 1 1 1 AMP-binding enzyme DASH_Duo1 PF08651.10 VDM92969.1 - 0.075 12.8 0.1 0.6 9.9 0.1 2.3 2 0 0 2 2 2 0 DASH complex subunit Duo1 I-set PF07679.16 VDM92971.1 - 1.6e-33 114.6 0.2 5.4e-13 48.8 0.0 3.9 3 1 1 4 4 4 3 Immunoglobulin I-set domain Ig_3 PF13927.6 VDM92971.1 - 2e-21 76.4 0.1 4.3e-09 36.9 0.0 3.9 3 1 0 3 3 3 3 Immunoglobulin domain ig PF00047.25 VDM92971.1 - 4e-18 65.4 0.0 1.3e-06 28.4 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain V-set PF07686.17 VDM92971.1 - 2.5e-11 43.7 0.0 0.00023 21.3 0.0 3.5 3 1 0 3 3 3 2 Immunoglobulin V-set domain Ig_2 PF13895.6 VDM92971.1 - 3e-10 40.3 0.0 0.002 18.4 0.0 3.5 3 0 0 3 3 3 2 Immunoglobulin domain Ig_6 PF18452.1 VDM92971.1 - 1.5e-06 27.7 0.0 0.11 12.1 0.0 3.3 3 0 0 3 3 3 3 Immunoglobulin domain Ig_4 PF16680.5 VDM92971.1 - 0.00011 22.3 0.0 1.5 9.1 0.0 4.0 3 1 0 3 3 3 1 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 VDM92971.1 - 0.00012 22.4 0.1 1.1 9.7 0.0 3.6 3 1 0 3 3 3 1 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain Izumo-Ig PF16706.5 VDM92971.1 - 0.00027 20.9 0.0 1.9 8.6 0.0 3.3 3 0 0 3 3 3 2 Izumo-like Immunoglobulin domain Receptor_2B4 PF11465.8 VDM92971.1 - 0.0039 17.4 0.0 5.5 7.2 0.0 3.1 3 0 0 3 3 3 1 Natural killer cell receptor 2B4 V-set_CD47 PF08204.11 VDM92971.1 - 0.024 14.6 0.1 0.72 9.8 0.0 2.7 3 0 0 3 3 3 0 CD47 immunoglobulin-like domain C2-set PF05790.15 VDM92971.1 - 0.038 14.2 0.2 3 8.1 0.1 3.1 3 1 0 3 3 3 0 Immunoglobulin C2-set domain DUF4175 PF13779.6 VDM92971.1 - 0.24 9.2 0.0 0.29 9.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Helicase_C_4 PF13871.6 VDM92974.1 - 2.2e-42 145.7 0.0 3.1e-42 145.1 0.0 1.2 1 0 0 1 1 1 1 C-terminal domain on Strawberry notch homologue CortBP2 PF09727.9 VDM92979.1 - 8.2e-61 205.3 17.4 8.2e-61 205.3 17.4 2.5 3 0 0 3 3 3 1 Cortactin-binding protein-2 DUF4407 PF14362.6 VDM92979.1 - 0.00089 18.7 10.1 0.00089 18.7 10.1 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4407) DUF4164 PF13747.6 VDM92979.1 - 0.011 16.0 4.1 0.011 16.0 4.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) TPR_MLP1_2 PF07926.12 VDM92979.1 - 0.024 14.7 4.3 0.024 14.7 4.3 2.8 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Fungal_TACC PF12709.7 VDM92979.1 - 0.51 10.8 11.4 2 8.9 0.2 3.1 3 0 0 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins sCache_2 PF17200.4 VDM92979.1 - 1.6 8.5 5.1 6.4 6.6 0.1 2.4 2 0 0 2 2 2 0 Single Cache domain 2 LMBR1 PF04791.16 VDM92979.1 - 1.9 7.3 8.2 2.9 6.7 8.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-Q PF13094.6 VDM92979.1 - 3.2 7.9 24.9 4.9 7.3 5.9 3.4 2 1 1 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit Spc24 PF08286.11 VDM92979.1 - 4.1 7.7 10.9 20 5.5 0.6 3.2 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 Cep57_CLD_2 PF14197.6 VDM92979.1 - 4.3 7.5 17.2 0.32 11.1 3.6 2.7 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 PEP-utilisers_N PF05524.13 VDM92979.1 - 8.9 6.5 10.3 4.6 7.4 1.2 2.7 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Mesd PF10185.9 VDM92980.1 - 1e-34 119.7 0.0 1.1e-34 119.6 0.0 1.0 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor Mesd PF10185.9 VDM92981.1 - 7.1e-32 110.5 0.1 7.7e-32 110.4 0.1 1.0 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor Coatomer_WDAD PF04053.14 VDM92982.1 - 0.0046 16.1 0.5 0.008 15.3 0.2 1.5 2 0 0 2 2 2 1 Coatomer WD associated region TPR_8 PF13181.6 VDM92982.1 - 0.049 13.9 0.1 0.53 10.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Ank_4 PF13637.6 VDM92991.1 - 4.7e-09 36.6 0.1 1.2e-08 35.3 0.1 1.7 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDM92991.1 - 6.2e-09 36.3 0.1 1e-08 35.6 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 VDM92991.1 - 4.7e-07 30.0 0.1 1.4e-06 28.5 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 VDM92991.1 - 6.9e-05 23.1 2.1 7.1e-05 23.1 0.3 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 VDM92991.1 - 0.00031 20.9 0.1 0.0025 18.2 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat zf-C2H2_4 PF13894.6 VDM92992.1 - 0.12 13.3 7.3 1.6 9.8 0.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 VDM92992.1 - 0.37 11.3 6.5 1.6 9.3 0.2 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 VDM92992.1 - 0.61 10.4 10.6 3.5 8.0 2.3 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 VDM92992.1 - 4.9 7.0 6.1 16 5.4 0.2 2.7 3 0 0 3 3 3 0 zinc-finger C2H2-type Spt5_N PF11942.8 VDM92994.1 - 6.5 7.8 13.8 6.2 7.9 13.8 1.0 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DUF2207 PF09972.9 VDM92995.1 - 0.048 12.4 0.2 0.047 12.5 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HECA PF15353.6 VDM92995.1 - 0.15 12.3 1.6 0.38 11.0 1.6 1.7 1 1 0 1 1 1 0 Headcase protein family homologue DUF3678 PF12435.8 VDM92997.1 - 0.018 14.4 0.1 0.056 12.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Ank_2 PF12796.7 VDM92999.1 - 1e-35 122.2 1.9 7.7e-12 45.6 0.6 4.3 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 VDM92999.1 - 1.9e-27 95.3 5.4 2.5e-05 24.7 0.3 6.9 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 VDM92999.1 - 1.2e-25 89.2 3.6 7.1e-07 29.4 0.2 5.9 4 3 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 VDM92999.1 - 1.7e-23 80.2 3.4 0.016 15.6 0.0 8.9 9 0 0 9 9 9 5 Ankyrin repeat Ank PF00023.30 VDM92999.1 - 1.4e-20 72.8 7.2 0.0067 16.8 0.0 7.4 8 0 0 8 8 8 6 Ankyrin repeat DUF1843 PF08898.10 VDM92999.1 - 0.1 13.1 0.3 0.43 11.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) FA_desaturase PF00487.24 VDM93003.1 - 2.4e-14 53.8 0.3 2.8e-14 53.6 0.3 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 VDM93004.1 - 2.2e-05 24.5 0.1 3.7e-05 23.8 0.1 1.4 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DWNN PF08783.11 VDM93012.1 - 2.8e-25 88.4 0.3 4e-25 87.9 0.3 1.3 1 0 0 1 1 1 1 DWNN domain cEGF PF12662.7 VDM93014.1 - 0.00036 20.4 0.4 0.00097 19.0 0.4 1.8 1 0 0 1 1 1 1 Complement Clr-like EGF-like FXa_inhibition PF14670.6 VDM93014.1 - 0.0046 17.2 5.1 0.0091 16.3 5.1 1.5 1 0 0 1 1 1 1 Coagulation Factor Xa inhibitory site DUF3659 PF12396.8 VDM93014.1 - 0.005 16.7 6.9 0.9 9.5 0.2 6.4 7 2 0 7 7 7 1 Protein of unknown function (DUF3659) fn3 PF00041.21 VDM93014.1 - 0.0076 16.6 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain TruB_C PF09142.11 VDM93014.1 - 0.05 13.4 0.8 19 5.1 0.0 4.8 5 0 0 5 5 5 0 tRNA Pseudouridine synthase II, C terminal Sugar_tr PF00083.24 VDM93016.1 - 1.4e-20 73.6 6.0 1.6e-20 73.4 6.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDM93016.1 - 1.9e-05 23.8 0.2 2.2e-05 23.6 0.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PIG-P PF08510.12 VDM93016.1 - 4.7 7.1 8.9 15 5.5 8.6 1.8 1 1 0 1 1 1 0 PIG-P Med20 PF08612.11 VDM93017.1 - 8e-24 84.3 0.0 8.9e-24 84.1 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Frag1 PF10277.9 VDM93022.1 - 5.7e-05 22.8 11.4 9.9e-05 22.0 11.4 1.4 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family 7TMR-DISM_7TM PF07695.11 VDM93022.1 - 0.67 9.8 10.9 0.57 10.0 8.6 2.0 1 1 1 2 2 2 0 7TM diverse intracellular signalling EB1 PF03271.17 VDM93024.1 - 1.9e-09 37.6 0.6 4e-09 36.6 0.6 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 VDM93024.1 - 1.1e-07 32.0 1.3 1.8e-07 31.3 0.5 1.7 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 VDM93024.1 - 0.001 18.8 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain Myosin_N PF02736.19 VDM93033.1 - 5.7e-16 58.1 0.8 9.3e-16 57.4 0.5 1.5 1 1 0 1 1 1 1 Myosin N-terminal SH3-like domain Myosin_head PF00063.21 VDM93033.1 - 0.00081 17.7 0.0 0.001 17.4 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Molydop_binding PF01568.21 VDM93033.1 - 0.011 15.8 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain DUF4889 PF16230.5 VDM93033.1 - 0.016 15.4 0.2 0.025 14.8 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) LEA_3 PF03242.13 VDM93033.1 - 0.072 13.8 0.3 0.12 13.1 0.2 1.4 1 1 0 1 1 1 0 Late embryogenesis abundant protein zf-C2H2_jaz PF12171.8 VDM93035.1 - 0.076 13.3 2.5 0.076 13.3 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Skp1 PF01466.19 VDM93042.1 - 3.1e-17 62.4 0.1 3.1e-17 62.4 0.1 2.7 3 0 0 3 3 3 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 VDM93042.1 - 8.2e-10 38.7 0.6 1.7e-09 37.7 0.6 1.6 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain Collagen PF01391.18 VDM93044.1 - 5.5e-09 35.7 20.1 6.4e-09 35.4 20.1 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Collagen PF01391.18 VDM93045.1 - 8.4e-11 41.5 24.6 1.2e-10 41.0 24.6 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Formin_GBD_N PF18382.1 VDM93052.1 - 4.2e-34 116.9 0.1 4.7e-34 116.8 0.1 1.0 1 0 0 1 1 1 1 Formin N-terminal GTPase-binding domain PI3K_1B_p101 PF10486.9 VDM93053.1 - 0.28 8.9 3.5 0.32 8.7 3.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Gp_dh_C PF02800.20 VDM93058.1 - 3.4e-70 234.7 0.0 4.1e-70 234.4 0.0 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_C PF02800.20 VDM93059.1 - 5.5e-67 224.3 0.0 6.5e-67 224.0 0.0 1.0 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PAP2 PF01569.21 VDM93064.1 - 1.3e-20 73.6 0.3 1.3e-20 73.6 0.3 1.5 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 VDM93064.1 - 1.1e-06 28.5 0.5 1.7e-06 27.9 0.2 1.6 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.6 VDM93064.1 - 0.013 16.0 0.2 0.013 16.0 0.2 2.5 2 1 0 2 2 2 0 PAP2 superfamily C-terminal PI3K_1B_p101 PF10486.9 VDM93069.1 - 0.056 11.2 2.4 0.056 11.2 2.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RAP1 PF07218.11 VDM93069.1 - 7.4 4.7 7.4 6.9 4.8 7.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RhoGEF PF00621.20 VDM93070.1 - 4.6e-33 115.0 1.8 6.8e-33 114.4 1.8 1.3 1 0 0 1 1 1 1 RhoGEF domain C1_1 PF00130.22 VDM93070.1 - 1.5e-09 37.6 4.4 1.5e-09 37.6 4.4 1.8 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 VDM93070.1 - 7.1e-05 23.0 1.5 0.00017 21.8 1.5 1.6 1 0 0 1 1 1 1 C1 domain PHD PF00628.29 VDM93070.1 - 1.2 9.1 6.3 5 7.1 6.3 2.0 1 1 0 1 1 1 0 PHD-finger NOB1_Zn_bind PF08772.11 VDM93070.1 - 1.4 9.2 5.9 5.8 7.1 0.0 2.5 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like PHD_2 PF13831.6 VDM93070.1 - 2.3 7.9 10.1 0.21 11.1 2.6 2.7 3 0 0 3 3 3 0 PHD-finger DZR PF12773.7 VDM93070.1 - 3.5 7.7 7.6 0.68 10.0 3.2 2.1 2 0 0 2 2 2 0 Double zinc ribbon Zn_ribbon_17 PF17120.5 VDM93070.1 - 7.3 6.3 8.4 1.1 9.0 3.8 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type CCSAP PF15748.5 VDM93072.1 - 0.02 15.1 13.8 0.025 14.8 13.8 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SelP_N PF04592.14 VDM93072.1 - 0.055 12.9 11.2 0.063 12.7 11.2 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PCEMA1 PF07418.11 VDM93072.1 - 0.072 12.6 8.4 0.083 12.4 8.4 1.0 1 0 0 1 1 1 0 Acidic phosphoprotein precursor PCEMA1 RNA_pol_Rbc25 PF08292.12 VDM93072.1 - 0.083 13.1 8.9 0.11 12.8 8.9 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 Peptidase_S49_N PF08496.10 VDM93072.1 - 0.095 12.8 9.4 0.1 12.6 9.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal UNC-79 PF14776.6 VDM93072.1 - 0.12 11.1 11.7 0.14 10.9 11.7 1.0 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 DUF913 PF06025.12 VDM93072.1 - 0.13 11.2 8.0 0.14 11.1 8.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AIF_C PF14721.6 VDM93072.1 - 0.15 12.5 11.2 0.18 12.2 11.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CKAP2_C PF15297.6 VDM93072.1 - 0.15 11.1 14.4 0.18 10.9 14.4 1.0 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DREPP PF05558.12 VDM93072.1 - 0.16 11.8 3.4 0.18 11.7 3.4 1.1 1 0 0 1 1 1 0 DREPP plasma membrane polypeptide Presenilin PF01080.17 VDM93072.1 - 0.21 10.3 16.5 0.23 10.2 16.5 1.1 1 0 0 1 1 1 0 Presenilin DUF1682 PF07946.14 VDM93072.1 - 0.26 10.4 14.5 0.29 10.3 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) V_ATPase_I PF01496.19 VDM93072.1 - 0.27 9.1 13.5 0.29 9.0 13.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Serinc PF03348.15 VDM93072.1 - 0.28 10.1 8.3 0.29 10.0 8.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FTO_NTD PF12933.7 VDM93072.1 - 0.36 10.0 10.4 0.39 9.9 10.4 1.0 1 0 0 1 1 1 0 FTO catalytic domain Methyltransf_32 PF13679.6 VDM93072.1 - 0.41 10.6 12.2 0.44 10.5 12.2 1.1 1 0 0 1 1 1 0 Methyltransferase domain CSG2 PF16965.5 VDM93072.1 - 0.43 9.5 8.1 0.48 9.3 8.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 VDM93072.1 - 0.48 9.6 5.3 0.5 9.5 5.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter YABBY PF04690.13 VDM93072.1 - 0.48 11.0 10.7 0.64 10.6 10.7 1.1 1 0 0 1 1 1 0 YABBY protein Connexin PF00029.19 VDM93072.1 - 0.49 10.1 9.6 0.5 10.1 9.6 1.1 1 0 0 1 1 1 0 Connexin Velvet PF11754.8 VDM93072.1 - 0.55 10.1 13.3 0.64 9.9 13.3 1.0 1 0 0 1 1 1 0 Velvet factor DUF2828 PF11443.8 VDM93072.1 - 0.57 8.2 12.6 0.55 8.2 12.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) TFB6 PF17110.5 VDM93072.1 - 0.59 9.9 8.9 0.66 9.7 8.9 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH ATP11 PF06644.11 VDM93072.1 - 0.65 9.7 18.6 0.78 9.5 18.6 1.0 1 0 0 1 1 1 0 ATP11 protein Asp-B-Hydro_N PF05279.11 VDM93072.1 - 0.69 9.9 12.5 0.77 9.8 12.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4446 PF14584.6 VDM93072.1 - 0.71 9.9 7.1 0.8 9.7 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Ctr PF04145.15 VDM93072.1 - 0.77 10.4 7.4 0.89 10.2 7.4 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Pex14_N PF04695.13 VDM93072.1 - 0.86 10.2 22.7 0.99 10.0 22.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Neur_chan_memb PF02932.16 VDM93072.1 - 1 9.4 10.6 1.1 9.3 10.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 VDM93072.1 - 1.1 8.3 9.5 1.1 8.2 9.5 1.1 1 0 0 1 1 1 0 CLN3 protein tRNA-synt_1c PF00749.21 VDM93072.1 - 1.1 8.0 10.2 1.5 7.7 10.2 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Kei1 PF08552.11 VDM93072.1 - 1.2 9.0 10.2 1.6 8.6 10.2 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Folate_carrier PF01770.18 VDM93072.1 - 1.2 7.7 7.2 1.4 7.6 7.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier EOS1 PF12326.8 VDM93072.1 - 1.3 8.9 8.6 1.5 8.7 8.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein Suf PF05843.14 VDM93072.1 - 1.5 8.7 18.7 1.8 8.4 18.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Asparaginase_2 PF01112.18 VDM93072.1 - 1.6 7.7 8.5 1.8 7.5 8.5 1.1 1 0 0 1 1 1 0 Asparaginase TFIIA PF03153.13 VDM93072.1 - 1.7 8.5 36.1 1.9 8.4 36.1 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4758 PF15950.5 VDM93072.1 - 1.7 9.0 6.3 2.1 8.7 6.3 1.1 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein DDHD PF02862.17 VDM93072.1 - 1.8 8.7 14.2 2 8.5 14.2 1.1 1 0 0 1 1 1 0 DDHD domain SpoIIP PF07454.11 VDM93072.1 - 1.8 8.0 18.1 1.9 7.8 18.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF853 PF05872.12 VDM93072.1 - 1.8 7.0 10.3 1.9 7.0 10.3 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Rrn6 PF10214.9 VDM93072.1 - 2 6.8 18.7 2.2 6.7 18.7 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Hydin_ADK PF17213.3 VDM93072.1 - 2.3 8.4 14.2 3.2 8.0 14.2 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Folliculin PF11704.8 VDM93072.1 - 2.6 7.9 13.7 3.1 7.6 13.7 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport baeRF_family12 PF18856.1 VDM93072.1 - 2.6 8.6 9.9 3.1 8.4 9.9 1.1 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Glyco_transf_41 PF13844.6 VDM93072.1 - 2.6 6.4 9.4 2.7 6.3 9.4 1.0 1 0 0 1 1 1 0 Glycosyl transferase family 41 FPN1 PF06963.12 VDM93072.1 - 2.9 6.4 5.4 3.2 6.2 5.4 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) eIF-3_zeta PF05091.12 VDM93072.1 - 3.6 6.4 21.1 4.2 6.2 21.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) ALMT PF11744.8 VDM93072.1 - 3.7 6.3 14.0 4.2 6.1 14.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter O-antigen_lig PF13425.6 VDM93072.1 - 3.8 6.2 9.9 4.3 6.0 9.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Sec62 PF03839.16 VDM93072.1 - 4.1 6.9 12.4 4.7 6.7 12.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PTPRCAP PF15713.5 VDM93072.1 - 4.2 7.7 16.6 4.7 7.5 16.6 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PigN PF04987.14 VDM93072.1 - 4.3 6.1 5.2 4.2 6.1 5.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) RR_TM4-6 PF06459.12 VDM93072.1 - 4.5 7.0 18.4 5.1 6.8 18.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UPF0560 PF10577.9 VDM93072.1 - 5.3 5.4 24.8 5.6 5.3 24.8 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PAT1 PF09770.9 VDM93072.1 - 5.4 5.2 24.8 6.1 5.0 24.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CobT PF06213.12 VDM93072.1 - 6 6.2 23.1 6.9 6.0 23.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4407 PF14362.6 VDM93072.1 - 6.1 6.1 20.4 6.7 6.0 20.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ureide_permease PF07168.11 VDM93072.1 - 6.3 5.4 7.5 6.1 5.5 7.5 1.1 1 0 0 1 1 1 0 Ureide permease DUF4746 PF15928.5 VDM93072.1 - 7 6.0 14.1 8.1 5.8 14.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Paf1 PF03985.13 VDM93072.1 - 7.4 5.5 20.9 8.7 5.2 20.9 1.0 1 0 0 1 1 1 0 Paf1 MMU163 PF17119.5 VDM93072.1 - 7.7 5.6 9.5 8.5 5.4 9.5 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF2126 PF09899.9 VDM93072.1 - 8.5 4.3 11.6 9.1 4.2 11.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FliP PF00813.20 VDM93072.1 - 8.7 6.2 7.1 10 5.9 7.1 1.2 1 0 0 1 1 1 0 FliP family CPSF100_C PF13299.6 VDM93072.1 - 8.8 6.5 13.5 11 6.2 13.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal MMR1 PF08505.10 VDM93072.1 - 8.9 6.5 23.7 11 6.2 23.7 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein HCO3_cotransp PF00955.21 VDM93072.1 - 9.1 5.0 9.2 9.4 4.9 9.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family Collagen PF01391.18 VDM93075.1 - 1.6e-15 56.6 67.8 1.1e-10 41.1 36.9 2.1 1 1 1 2 2 2 2 Collagen triple helix repeat (20 copies) DUF229 PF02995.17 VDM93077.1 - 4e-52 177.5 1.0 5.2e-32 111.1 0.3 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF229) Urm1 PF09138.11 VDM93077.1 - 0.03 14.6 0.0 0.068 13.5 0.0 1.6 1 0 0 1 1 1 0 Urm1 (Ubiquitin related modifier) SUIM_assoc PF16619.5 VDM93080.1 - 0.064 13.3 3.0 0.084 13.0 3.0 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 WD40 PF00400.32 VDM93081.1 - 1.4e-14 54.2 17.2 0.00013 22.7 0.3 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDM93081.1 - 1.1e-10 41.6 4.3 0.072 13.4 0.1 5.8 2 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain DUF3545 PF12065.8 VDM93081.1 - 0.044 13.8 0.2 0.088 12.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) Gmad1 PF10647.9 VDM93081.1 - 0.098 12.4 1.7 0.19 11.4 0.5 2.0 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Zona_pellucida PF00100.23 VDM93084.1 - 6.1e-15 55.7 2.6 7.4e-15 55.4 2.6 1.1 1 0 0 1 1 1 1 Zona pellucida-like domain I-set PF07679.16 VDM93086.1 - 0.0001 22.3 0.0 0.0013 18.8 0.0 2.5 2 0 0 2 2 2 1 Immunoglobulin I-set domain Ig_3 PF13927.6 VDM93086.1 - 0.00015 22.3 0.7 0.00055 20.5 0.1 2.2 2 2 0 2 2 2 1 Immunoglobulin domain Herpes_UL73 PF03554.13 VDM93086.1 - 0.17 11.9 2.5 0.46 10.5 2.5 1.8 1 0 0 1 1 1 0 UL73 viral envelope glycoprotein Neur_chan_LBD PF02931.23 VDM93088.1 - 1.1e-30 106.7 0.1 1.6e-30 106.2 0.1 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 VDM93088.1 - 1.7e-13 51.2 2.5 2.5e-13 50.6 2.5 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region EF-hand_1 PF00036.32 VDM93090.1 - 9e-18 62.4 4.6 5.3e-09 35.0 0.4 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 VDM93090.1 - 6.8e-14 52.1 0.4 8.8e-14 51.7 0.4 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 VDM93090.1 - 3.5e-13 49.2 1.3 9.3e-13 47.8 1.3 1.7 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 VDM93090.1 - 7.2e-13 47.3 2.4 7.7e-07 28.6 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 VDM93090.1 - 1.5e-12 46.4 2.3 2.5e-05 23.6 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 VDM93090.1 - 9.7e-06 25.5 0.4 1.5e-05 24.8 0.4 1.4 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 VDM93090.1 - 0.002 18.5 0.1 0.0038 17.5 0.1 1.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 VDM93090.1 - 0.0026 17.9 0.7 0.16 12.2 1.0 2.2 1 1 1 2 2 2 2 Dockerin type I domain EF-hand_11 PF08976.11 VDM93090.1 - 0.0066 17.3 0.1 0.0081 17.0 0.1 1.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_9 PF14658.6 VDM93090.1 - 0.027 14.8 0.0 0.04 14.2 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain PAN_1 PF00024.26 VDM93101.1 - 8.4e-15 54.5 5.8 8.4e-09 35.3 0.6 2.2 2 0 0 2 2 2 2 PAN domain AhpC-TSA PF00578.21 VDM93104.1 - 2.7e-33 114.5 0.0 3.3e-33 114.2 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 VDM93104.1 - 4.6e-14 52.4 0.0 6.4e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin Copine PF07002.16 VDM93106.1 - 0.072 12.5 0.0 0.096 12.1 0.0 1.1 1 0 0 1 1 1 0 Copine Ribosomal_60s PF00428.19 VDM93111.1 - 0.15 12.6 11.1 0.16 12.6 11.1 1.0 1 0 0 1 1 1 0 60s Acidic ribosomal protein AIP3 PF03915.13 VDM93115.1 - 5.8e-11 42.1 0.0 6.2e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 fn3 PF00041.21 VDM93117.1 - 2.5e-18 66.2 1.3 8.4e-12 45.3 0.1 2.5 2 0 0 2 2 2 2 Fibronectin type III domain fn3_4 PF16794.5 VDM93117.1 - 0.0089 15.9 0.1 0.044 13.7 0.0 2.0 2 0 0 2 2 2 1 Fibronectin-III type domain Tissue_fac PF01108.17 VDM93117.1 - 0.014 15.3 1.1 0.021 14.7 0.1 1.7 2 0 0 2 2 2 0 Tissue factor PDZ_2 PF13180.6 VDM93119.1 - 0.021 15.1 0.1 0.035 14.4 0.1 1.4 1 0 0 1 1 1 0 PDZ domain WD40 PF00400.32 VDM93122.1 - 5.8e-06 26.9 0.1 0.057 14.3 0.0 5.2 6 0 0 6 6 6 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 VDM93122.1 - 0.00011 22.5 0.1 6 7.3 0.0 4.6 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 VDM93122.1 - 0.0014 17.4 0.0 0.086 11.5 0.0 2.5 2 1 0 2 2 2 2 Nucleoporin Nup120/160 NUP214 PF16755.5 VDM93122.1 - 0.0036 16.6 0.1 0.011 14.9 0.1 1.8 1 1 1 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Ge1_WD40 PF16529.5 VDM93122.1 - 0.063 12.2 0.3 6.4 5.6 0.0 2.9 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CS PF04969.16 VDM93123.1 - 0.001 20.0 0.0 0.0014 19.6 0.0 1.2 1 0 0 1 1 1 1 CS domain Aa_trans PF01490.18 VDM93131.1 - 1.8e-18 66.5 9.3 6e-18 64.7 9.3 1.7 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein PspC PF04024.12 VDM93131.1 - 0.7 9.8 3.0 0.41 10.5 0.1 2.0 2 0 0 2 2 2 0 PspC domain FRB_dom PF08771.11 VDM93134.1 - 1.9e-07 31.4 0.1 2e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 FKBP12-rapamycin binding domain Kelch_6 PF13964.6 VDM93141.1 - 0.011 15.9 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_1 PF01344.25 VDM93141.1 - 0.099 12.2 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Kelch motif HGAL PF15666.5 VDM93144.1 - 0.16 12.1 0.0 0.2 11.8 0.0 1.1 1 0 0 1 1 1 0 Germinal center-associated lymphoma PPV_E1_C PF00519.17 VDM93146.1 - 0.069 12.0 0.0 0.075 11.9 0.0 1.0 1 0 0 1 1 1 0 Papillomavirus helicase SPW PF03779.14 VDM93149.1 - 0.096 12.3 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 SPW repeat EGF PF00008.27 VDM93150.1 - 6.2e-35 119.1 106.5 1.3e-07 31.8 12.3 8.5 8 0 0 8 8 8 6 EGF-like domain hEGF PF12661.7 VDM93150.1 - 6.6e-23 80.5 94.8 4e-06 27.2 11.1 9.3 9 0 0 9 9 9 7 Human growth factor-like EGF EGF_CA PF07645.15 VDM93150.1 - 1e-20 73.6 101.6 3.7e-10 39.9 12.0 8.3 4 3 4 8 8 8 4 Calcium-binding EGF domain EGF_2 PF07974.13 VDM93150.1 - 3.3e-07 30.6 111.9 0.00022 21.5 11.8 8.5 8 0 0 8 8 8 5 EGF-like domain EGF_3 PF12947.7 VDM93150.1 - 0.00011 22.3 92.4 0.011 15.9 5.7 8.4 7 2 1 8 8 8 4 EGF domain FXa_inhibition PF14670.6 VDM93150.1 - 0.00034 20.8 95.0 0.013 15.8 9.8 8.5 4 2 3 7 7 7 4 Coagulation Factor Xa inhibitory site Plasmod_Pvs28 PF06247.11 VDM93150.1 - 0.001 19.3 0.3 0.001 19.3 0.3 7.1 5 2 1 6 6 6 1 Pvs28 EGF domain EGF_alliinase PF04863.13 VDM93150.1 - 0.018 15.5 5.7 0.018 15.5 5.7 8.0 4 3 3 8 8 8 0 Alliinase EGF-like domain cEGF PF12662.7 VDM93150.1 - 0.036 14.0 6.0 0.036 14.0 6.0 10.9 8 3 2 10 10 10 0 Complement Clr-like EGF-like TTR-52 PF01060.23 VDM93152.1 - 3.6e-19 69.3 0.0 4.6e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 Transthyretin-like family bMG3 PF11974.8 VDM93152.1 - 0.017 15.1 0.0 0.024 14.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain MFS_1 PF07690.16 VDM93154.1 - 2.1e-45 155.2 22.8 2.5e-45 154.9 22.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 VDM93154.1 - 1.8e-07 30.4 8.7 2e-07 30.3 8.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter Laminin_G_2 PF02210.24 VDM93156.1 - 9.4e-09 35.9 0.2 1.2e-05 25.9 0.1 2.2 2 0 0 2 2 2 2 Laminin G domain Laminin_G_1 PF00054.23 VDM93156.1 - 1.3e-05 25.5 0.0 0.043 14.0 0.0 2.2 2 0 0 2 2 2 2 Laminin G domain hEGF PF12661.7 VDM93156.1 - 0.0085 16.7 7.7 0.018 15.6 7.7 1.6 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_2 PF07974.13 VDM93156.1 - 0.033 14.6 9.7 0.056 13.8 9.7 1.4 1 0 0 1 1 1 0 EGF-like domain EGF PF00008.27 VDM93156.1 - 0.11 12.9 4.6 0.2 12.0 4.6 1.4 1 0 0 1 1 1 0 EGF-like domain CPSF73-100_C PF11718.8 VDM93157.1 - 4.2e-39 134.3 0.4 1.2e-38 132.9 0.4 1.6 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term FeS PF04060.13 VDM93158.1 - 0.11 12.1 5.6 3.9 7.2 0.0 3.1 3 0 0 3 3 3 0 Putative Fe-S cluster PHD PF00628.29 VDM93158.1 - 0.58 10.1 7.7 3.7 7.5 0.3 2.6 2 0 0 2 2 2 0 PHD-finger Imm40 PF15569.6 VDM93159.1 - 0.073 13.2 0.2 1 9.5 0.0 2.3 2 0 0 2 2 2 0 Immunity protein 40 Peptidase_M4_C PF02868.15 VDM93162.1 - 0.084 12.7 0.0 0.084 12.7 0.0 1.0 1 0 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain DUF1036 PF06282.11 VDM93165.1 - 0.023 15.2 0.6 0.045 14.3 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1036) RT_RNaseH_2 PF17919.1 VDM93165.1 - 0.076 13.1 0.1 0.24 11.4 0.0 1.8 1 1 0 1 1 1 0 RNase H-like domain found in reverse transcriptase GT-D PF08759.11 VDM93165.1 - 0.085 12.5 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold ZZ PF00569.17 VDM93167.1 - 1.9e-11 43.6 4.3 1.9e-11 43.6 4.3 2.2 3 0 0 3 3 3 1 Zinc finger, ZZ type zf-Di19 PF05605.12 VDM93167.1 - 1.1e-08 35.2 3.7 2.1e-08 34.3 2.0 2.3 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding Zn_Tnp_IS1 PF03811.13 VDM93167.1 - 1.6 8.5 0.0 1.6 8.5 0.0 3.4 3 1 0 3 3 3 0 InsA N-terminal domain Sugar_tr PF00083.24 VDM93179.1 - 3.3e-15 55.9 11.2 4.4e-15 55.5 11.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDM93179.1 - 3e-10 39.6 24.4 2.1e-05 23.6 17.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily CCDC53 PF10152.9 VDM93181.1 - 0.00017 22.0 0.2 0.0005 20.5 0.0 1.7 2 0 0 2 2 2 1 Subunit CCDC53 of WASH complex CTF_NFI PF00859.18 VDM93181.1 - 0.0092 15.9 0.1 0.0094 15.9 0.1 1.0 1 0 0 1 1 1 1 CTF/NF-I family transcription modulation region CX PF01705.19 VDM93184.1 - 1 9.9 6.5 0.29 11.7 2.6 2.1 2 0 0 2 2 2 0 CX module Pkinase PF00069.25 VDM93186.1 - 0.00013 21.4 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Cytochrom_B559a PF00284.20 VDM93186.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit DUF273 PF03314.14 VDM93194.1 - 9.6e-26 90.7 2.1 1.3e-25 90.3 2.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF273 Glyco_transf_34 PF05637.12 VDM93194.1 - 0.01 15.6 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family MSC PF09402.10 VDM93194.1 - 0.052 13.0 0.1 0.066 12.7 0.1 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Anp1 PF03452.14 VDM93194.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.2 1 0 0 1 1 1 0 Anp1 zf-CCHC PF00098.23 VDM93195.1 - 3.2e-40 134.5 45.6 3.7e-08 33.1 3.6 5.2 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_4 PF14392.6 VDM93195.1 - 1.6e-10 40.5 28.6 0.002 17.8 0.9 5.1 5 0 0 5 5 5 5 Zinc knuckle zf-CCHC_3 PF13917.6 VDM93195.1 - 3.8e-09 36.4 33.1 0.023 14.6 1.4 5.1 3 2 2 5 5 5 5 Zinc knuckle zf-CCHC_6 PF15288.6 VDM93195.1 - 1.6e-07 31.1 33.6 0.0071 16.2 1.8 5.2 4 1 1 5 5 5 4 Zinc knuckle zf-CCHC_5 PF14787.6 VDM93195.1 - 2e-06 27.4 27.2 0.066 12.9 0.6 5.1 5 0 0 5 5 5 5 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 VDM93195.1 - 3.3e-06 26.8 40.6 0.0012 18.6 1.4 5.5 5 0 0 5 5 5 4 Zinc knuckle Coagulin PF02035.15 VDM93195.1 - 8.5e-06 25.8 11.5 1.8 8.5 0.1 4.8 1 1 4 5 5 5 4 Coagulin Collagen PF01391.18 VDM93202.1 - 6.3e-10 38.7 24.9 7.9e-10 38.3 24.9 1.1 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Collagen PF01391.18 VDM93203.1 - 3.3e-10 39.5 24.6 4.7e-10 39.1 24.6 1.2 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) zf-C3HC4 PF00097.25 VDM93212.1 - 8.9e-06 25.5 29.2 0.00064 19.5 0.8 2.8 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 VDM93212.1 - 2.2e-05 24.7 33.9 0.00029 21.1 18.9 3.3 3 1 0 3 3 3 2 Ring finger domain zf-RING_UBOX PF13445.6 VDM93212.1 - 0.00024 21.1 20.9 0.0087 16.1 13.1 2.9 2 1 0 2 2 2 2 RING-type zinc-finger zf-C3HC4_2 PF13923.6 VDM93212.1 - 0.0003 20.6 27.3 0.026 14.4 17.9 3.0 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 VDM93212.1 - 0.00052 19.9 33.3 0.019 14.9 21.2 2.8 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_11 PF17123.5 VDM93212.1 - 0.0018 18.0 4.9 0.0018 18.0 4.9 3.5 2 1 1 3 3 3 1 RING-like zinc finger CBM_17_28 PF03424.14 VDM93212.1 - 0.14 11.9 0.1 0.29 10.8 0.1 1.5 2 0 0 2 2 2 0 Carbohydrate binding domain (family 17/28) zf-RING_6 PF14835.6 VDM93212.1 - 6.3 6.8 14.9 1.6 8.6 8.5 2.5 2 0 0 2 2 2 0 zf-RING of BARD1-type protein A2M_BRD PF07703.14 VDM93223.1 - 3.5e-26 92.2 0.8 4.5e-26 91.9 0.8 1.2 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain Cohesin PF00963.18 VDM93223.1 - 0.0055 17.0 1.9 0.67 10.2 0.1 2.7 2 1 1 3 3 3 2 Cohesin domain Ig_C17orf99 PF17736.1 VDM93223.1 - 0.032 14.3 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 C17orf99 Ig domain DUF229 PF02995.17 VDM93227.1 - 1.4e-74 251.6 0.4 1.6e-74 251.3 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 VDM93227.1 - 0.0012 18.3 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 VDM93227.1 - 0.0038 16.9 0.0 0.0056 16.3 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 VDM93227.1 - 0.21 10.9 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily DUF229 PF02995.17 VDM93228.1 - 1.4e-74 251.6 0.4 1.6e-74 251.3 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase PF00884.23 VDM93228.1 - 0.0012 18.3 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 VDM93228.1 - 0.0038 16.9 0.0 0.0056 16.3 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 VDM93228.1 - 0.21 10.9 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily MFS_1 PF07690.16 VDM93236.1 - 8e-51 173.0 25.8 1e-50 172.7 25.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 VDM93236.1 - 8.9e-08 31.4 12.0 8.9e-08 31.4 12.0 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2929 PF11151.8 VDM93236.1 - 0.83 10.0 9.0 5.1 7.5 2.9 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2929) Ni_hydr_CYTB PF01292.20 VDM93236.1 - 4.7 6.8 11.9 2 8.0 7.6 2.3 1 1 2 3 3 3 0 Prokaryotic cytochrome b561 Meis_PKNOX_N PF16493.5 VDM93239.1 - 0.0064 16.8 0.1 0.0064 16.8 0.1 1.6 2 0 0 2 2 2 1 N-terminal of Homeobox Meis and PKNOX1 DUF3446 PF11928.8 VDM93239.1 - 0.012 15.8 0.5 0.014 15.6 0.5 1.1 1 0 0 1 1 1 0 Early growth response N-terminal domain Hydrophob_seed PF14547.6 VDM93240.1 - 0.065 13.5 0.1 0.074 13.3 0.1 1.1 1 0 0 1 1 1 0 Hydrophobic seed protein Kunitz_BPTI PF00014.23 VDM93241.1 - 5.2e-07 29.8 3.6 1.7e-06 28.1 3.6 1.9 1 0 0 1 1 1 1 Kunitz/Bovine pancreatic trypsin inhibitor domain Lustrin_cystein PF14625.6 VDM93241.1 - 0.003 17.9 2.0 0.003 17.9 2.0 2.5 2 0 0 2 2 2 1 Lustrin, cysteine-rich repeated domain EB PF01683.18 VDM93241.1 - 0.0038 17.5 3.2 0.0038 17.5 3.2 2.8 2 1 0 2 2 2 1 EB module E1-E2_ATPase PF00122.20 VDM93245.1 - 5.1e-32 110.8 0.5 5.8e-32 110.7 0.5 1.0 1 0 0 1 1 1 1 E1-E2 ATPase ThrE PF06738.12 VDM93245.1 - 0.014 14.7 1.9 1.4 8.3 1.2 2.3 2 0 0 2 2 2 0 Putative threonine/serine exporter SPC12 PF06645.13 VDM93245.1 - 0.021 14.9 2.4 0.04 14.0 2.4 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Pkinase PF00069.25 VDM93247.1 - 3.3e-21 75.9 0.1 3.5e-21 75.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM93247.1 - 2.4e-14 53.3 0.1 2.8e-14 53.0 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase CDK5_activator PF03261.15 VDM93249.1 - 0.014 14.9 0.0 0.015 14.8 0.0 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein 2-oxoacid_dh PF00198.23 VDM93254.1 - 1.6e-22 80.1 0.0 1.8e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) DUF2083 PF09856.9 VDM93256.1 - 0.05 13.4 2.3 0.063 13.1 2.3 1.1 1 0 0 1 1 1 0 Predicted transcriptional regulator (DUF2083) HAP1_N PF04849.13 VDM93258.1 - 8.9e-22 77.7 23.8 8.9e-22 77.7 23.8 1.4 2 0 0 2 2 2 1 HAP1 N-terminal conserved region Leu_zip PF15294.6 VDM93258.1 - 0.029 13.9 18.8 1.4 8.4 18.8 2.4 1 1 0 1 1 1 0 Leucine zipper TACC_C PF05010.14 VDM93258.1 - 0.05 13.4 19.4 0.1 12.4 17.6 2.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TMF_TATA_bd PF12325.8 VDM93258.1 - 0.063 13.5 24.3 0.15 12.3 6.2 3.0 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Exonuc_VII_S PF02609.16 VDM93258.1 - 0.17 12.0 6.9 0.12 12.5 1.7 2.9 2 1 1 3 3 3 0 Exonuclease VII small subunit Ax_dynein_light PF10211.9 VDM93258.1 - 0.18 11.8 18.6 0.65 9.9 7.9 2.4 1 1 0 2 2 2 0 Axonemal dynein light chain Taxilin PF09728.9 VDM93258.1 - 0.23 10.6 21.8 1.1 8.3 21.8 2.1 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF4407 PF14362.6 VDM93258.1 - 0.3 10.4 11.4 1.9 7.8 9.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ZapB PF06005.12 VDM93258.1 - 0.35 11.4 25.8 1.3 9.5 5.7 3.1 2 1 1 3 3 3 0 Cell division protein ZapB FUSC PF04632.12 VDM93258.1 - 0.44 9.0 2.2 0.5 8.8 2.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Lectin_N PF03954.14 VDM93258.1 - 0.56 9.9 8.8 9.6 6.0 8.8 2.6 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Adenylsucc_synt PF00709.21 VDM93258.1 - 0.64 8.9 3.7 0.95 8.3 3.7 1.2 1 0 0 1 1 1 0 Adenylosuccinate synthetase APG6_N PF17675.1 VDM93258.1 - 1.2 9.7 24.4 8.6 6.9 12.7 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region AATF-Che1 PF13339.6 VDM93258.1 - 1.4 9.6 14.9 56 4.4 12.4 2.8 2 1 0 2 2 1 0 Apoptosis antagonizing transcription factor Spc7 PF08317.11 VDM93258.1 - 1.8 7.4 23.1 0.94 8.3 7.6 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein DHR10 PF18595.1 VDM93258.1 - 1.8 8.6 23.4 0.17 11.9 6.5 2.8 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain GIT_CC PF16559.5 VDM93258.1 - 2.2 8.2 8.1 4 7.4 0.4 3.1 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Fez1 PF06818.15 VDM93258.1 - 3 8.2 21.3 2.1 8.8 12.7 2.5 1 1 1 2 2 2 0 Fez1 TSC22 PF01166.18 VDM93258.1 - 7.1 7.0 11.7 21 5.5 4.1 3.7 3 1 0 3 3 3 0 TSC-22/dip/bun family PRMT5_C PF17286.2 VDM93259.1 - 1.3e-41 142.4 0.0 1.9e-41 141.9 0.0 1.3 1 1 0 1 1 1 1 PRMT5 oligomerisation domain Kelch_1 PF01344.25 VDM93260.1 - 8e-48 159.8 1.6 1.1e-12 47.3 0.2 5.1 5 0 0 5 5 5 5 Kelch motif Kelch_6 PF13964.6 VDM93260.1 - 1.3e-26 91.9 0.1 3.9e-07 30.1 0.0 5.1 2 1 3 5 5 5 5 Kelch motif Kelch_2 PF07646.15 VDM93260.1 - 2.1e-24 84.5 0.2 1.1e-05 25.2 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 VDM93260.1 - 3.3e-23 81.5 0.1 1.4e-05 25.2 0.0 5.0 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 VDM93260.1 - 2.1e-20 72.4 0.8 1.7e-06 27.9 0.0 5.1 4 1 1 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 VDM93260.1 - 1.2e-08 34.8 3.4 0.17 11.9 0.1 5.0 5 0 0 5 5 5 3 Kelch motif Glyoxal_oxid_N PF07250.11 VDM93260.1 - 0.017 14.3 0.1 0.025 13.8 0.1 1.3 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus PEP_hydrolase PF09370.10 VDM93260.1 - 0.029 13.6 0.1 0.099 11.8 0.0 1.9 3 0 0 3 3 3 0 Phosphoenolpyruvate hydrolase-like A2M_BRD PF07703.14 VDM93263.1 - 8.1e-22 78.1 0.7 1e-21 77.7 0.7 1.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin bait region domain Cohesin PF00963.18 VDM93263.1 - 0.0032 17.7 0.6 0.56 10.5 0.1 2.3 2 0 0 2 2 2 2 Cohesin domain Pkinase PF00069.25 VDM93264.1 - 6e-09 35.6 0.2 6e-09 35.6 0.2 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 VDM93264.1 - 1.4e-06 27.8 0.1 3.1e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 VDM93264.1 - 0.013 15.1 0.2 0.028 14.0 0.0 1.7 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Myosin_head PF00063.21 VDM93271.1 - 1.5e-18 66.5 3.3 1.6e-18 66.3 3.3 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) UDPGT PF00201.18 VDM93279.1 - 1.2e-30 106.8 0.0 1.5e-30 106.5 0.0 1.0 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 VDM93279.1 - 4.7e-08 33.2 0.1 6.4e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 VDM93279.1 - 0.074 12.3 0.0 0.098 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 1 SR-25 PF10500.9 VDM93280.1 - 5.3 6.6 10.6 4.6 6.8 10.6 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PhoLip_ATPase_N PF16209.5 VDM93284.1 - 8e-27 92.7 2.0 1.6e-26 91.8 2.0 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 VDM93284.1 - 2.2e-05 24.1 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase 7TMR-DISM_7TM PF07695.11 VDM93291.1 - 0.051 13.5 12.8 0.19 11.6 12.7 1.7 1 1 0 1 1 1 0 7TM diverse intracellular signalling Yip1 PF04893.17 VDM93291.1 - 0.53 10.0 9.6 0.67 9.7 9.6 1.1 1 0 0 1 1 1 0 Yip1 domain DUF4191 PF13829.6 VDM93291.1 - 0.59 9.4 2.6 0.84 8.9 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) E1-E2_ATPase PF00122.20 VDM93291.1 - 1.2 8.6 8.3 0.71 9.4 2.9 2.0 2 0 0 2 2 2 0 E1-E2 ATPase RhoGAP PF00620.27 VDM93294.1 - 4.4e-41 140.2 0.1 7.1e-41 139.6 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain 7TM_GPCR_Srx PF10328.9 VDM93296.1 - 2.9e-06 27.1 17.9 4.4e-05 23.2 5.6 2.3 2 1 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srx 7TM_GPCR_Srt PF10321.9 VDM93296.1 - 0.00037 19.6 14.6 0.0014 17.7 2.8 2.1 2 0 0 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srt 7tm_1 PF00001.21 VDM93296.1 - 0.0054 16.1 9.0 0.15 11.4 1.4 2.1 2 0 0 2 2 2 2 7 transmembrane receptor (rhodopsin family) Maf1 PF09174.10 VDM93298.1 - 0.26 11.4 4.6 0.71 10.0 4.6 2.0 1 1 0 1 1 1 0 Maf1 regulator FGF PF00167.18 VDM93303.1 - 6.5e-33 113.5 0.2 1e-32 112.9 0.2 1.3 1 0 0 1 1 1 1 Fibroblast growth factor Rhodanese PF00581.20 VDM93312.1 - 5.6e-09 36.5 0.0 7.2e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain 2-oxoacid_dh PF00198.23 VDM93313.1 - 2.5e-31 108.9 0.0 2.8e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Histone_H2A_C PF16211.5 VDM93318.1 - 7.5e-14 51.2 0.1 1.4e-13 50.4 0.1 1.3 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 VDM93318.1 - 1.2e-08 35.3 0.1 1.8e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 VDM93318.1 - 0.0002 21.6 0.1 0.0005 20.3 0.0 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-18kDa PF02269.16 VDM93318.1 - 0.015 15.3 0.2 0.075 13.1 0.0 2.0 2 0 0 2 2 2 0 Transcription initiation factor IID, 18kD subunit TAFII28 PF04719.14 VDM93318.1 - 0.052 13.7 0.0 0.074 13.2 0.0 1.4 1 0 0 1 1 1 0 hTAFII28-like protein conserved region Sugar_tr PF00083.24 VDM93320.1 - 3.5e-26 92.1 1.2 4.2e-26 91.8 1.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDM93320.1 - 0.0015 17.5 6.2 0.0018 17.2 6.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily PSI_integrin PF17205.3 VDM93320.1 - 0.0069 16.1 3.9 0.012 15.4 3.9 1.3 1 0 0 1 1 1 1 Integrin plexin domain PSI PF01437.25 VDM93320.1 - 0.039 14.5 4.5 0.06 13.9 4.5 1.2 1 0 0 1 1 1 0 Plexin repeat p450 PF00067.22 VDM93325.1 - 0.011 14.6 0.2 0.019 13.8 0.1 1.5 2 0 0 2 2 2 0 Cytochrome P450 ABC_membrane PF00664.23 VDM93326.1 - 3.7e-29 102.2 1.7 4e-29 102.1 1.7 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region PDZ_6 PF17820.1 VDM93334.1 - 0.0009 19.0 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 VDM93334.1 - 0.0032 17.8 0.0 0.0042 17.4 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 VDM93334.1 - 0.029 14.7 0.1 0.047 14.0 0.1 1.3 1 0 0 1 1 1 0 PDZ domain An_peroxidase PF03098.15 VDM93335.1 - 2.1e-61 208.1 0.0 2.3e-61 208.0 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Pkinase_Tyr PF07714.17 VDM93339.1 - 0.035 13.4 0.1 0.042 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase LETM1 PF07766.13 VDM93343.1 - 7.1e-44 150.2 0.6 7.1e-44 150.2 0.6 2.3 2 1 0 2 2 2 1 LETM1-like protein SAP PF02037.27 VDM93343.1 - 0.0001 21.9 0.2 0.0022 17.7 0.2 3.0 2 1 0 2 2 2 1 SAP domain DUF1682 PF07946.14 VDM93343.1 - 0.0063 15.8 3.7 0.0063 15.8 3.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1682) Mod_r PF07200.13 VDM93343.1 - 0.99 9.5 13.7 0.86 9.7 5.6 2.5 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Syntaxin_2 PF14523.6 VDM93343.1 - 1 9.8 11.0 0.048 14.0 3.1 2.6 2 1 0 2 2 2 0 Syntaxin-like protein FAM76 PF16046.5 VDM93343.1 - 1.1 8.5 13.4 1.5 8.1 13.4 1.2 1 0 0 1 1 1 0 FAM76 protein HMG_box_2 PF09011.10 VDM93343.1 - 1.4 9.5 5.6 0.91 10.2 2.2 2.3 2 0 0 2 2 2 0 HMG-box domain Sec34 PF04136.15 VDM93343.1 - 2.2 8.2 8.7 0.2 11.5 3.2 2.1 2 1 0 2 2 2 0 Sec34-like family FliD_N PF02465.18 VDM93343.1 - 6.1 7.6 8.2 6 7.6 1.3 3.0 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus CAF20 PF17052.5 VDM93347.1 - 0.099 12.8 1.6 0.11 12.7 1.6 1.2 1 0 0 1 1 1 0 Cap associated factor Peptidase_M74 PF03411.13 VDM93347.1 - 0.11 12.0 4.6 0.14 11.7 4.6 1.1 1 0 0 1 1 1 0 Penicillin-insensitive murein endopeptidase Sugar_tr PF00083.24 VDM93360.1 - 2.9e-41 141.8 4.7 3.3e-41 141.6 4.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 VDM93360.1 - 9.2e-17 61.0 6.7 1.1e-16 60.7 6.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 VDM93360.1 - 0.022 14.0 2.6 0.026 13.8 2.6 1.2 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB DUF4022 PF13214.6 VDM93360.1 - 2 8.8 5.5 0.41 11.0 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4022) Metallophos PF00149.28 VDM93365.1 - 1.1e-35 124.0 0.0 1.4e-35 123.7 0.0 1.0 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 VDM93365.1 - 0.0036 17.5 0.0 0.0052 17.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Motile_Sperm PF00635.26 VDM93367.1 - 1.3e-22 79.7 0.0 1.4e-22 79.5 0.0 1.0 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Sortase PF04203.13 VDM93367.1 - 0.16 11.8 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 Sortase domain DUF948 PF06103.11 VDM93375.1 - 0.031 14.5 0.3 0.32 11.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CHASE2 PF05226.11 VDM93375.1 - 0.24 11.1 0.6 0.33 10.6 0.6 1.2 1 0 0 1 1 1 0 CHASE2 domain HMG_box PF00505.19 VDM93378.1 - 9.3e-18 64.4 0.7 9.3e-18 64.4 0.7 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 VDM93378.1 - 6.6e-06 26.6 1.1 6.6e-06 26.6 1.1 2.2 2 0 0 2 2 2 1 HMG-box domain TFIIA PF03153.13 VDM93378.1 - 0.0057 16.7 14.9 0.0067 16.5 14.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF728 PF05304.12 VDM93378.1 - 0.023 14.6 0.9 0.061 13.2 0.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF728) TMEM40 PF15817.5 VDM93378.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 40 family Virul_fac_BrkB PF03631.15 VDM93378.1 - 0.17 11.5 0.1 0.23 11.0 0.1 1.1 1 0 0 1 1 1 0 Virulence factor BrkB Holin_2-3 PF13272.6 VDM93378.1 - 0.19 12.1 2.4 11 6.4 0.1 2.1 2 0 0 2 2 2 0 Putative 2/3 transmembrane domain holin Androgen_recep PF02166.16 VDM93378.1 - 1.1 8.1 11.8 1.3 7.8 11.8 1.1 1 0 0 1 1 1 0 Androgen receptor FA_desaturase PF00487.24 VDM93380.1 - 5.6e-11 42.8 7.5 8e-11 42.3 7.5 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 VDM93381.1 - 0.03 14.5 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Cytochrome b5-like Heme/Steroid binding domain ABM PF03992.16 VDM93381.1 - 0.044 13.9 0.0 0.055 13.6 0.0 1.2 1 0 0 1 1 1 0 Antibiotic biosynthesis monooxygenase DUF1754 PF08555.10 VDM93384.1 - 0.0038 18.0 8.7 0.007 17.1 8.7 1.4 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) KptA_kDCL PF18176.1 VDM93384.1 - 0.012 15.5 2.7 0.014 15.3 2.7 1.1 1 0 0 1 1 1 0 KptA in kinetoplastid DICER domain ALMT PF11744.8 VDM93384.1 - 2.2 7.0 6.7 2.5 6.8 6.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SNF PF00209.18 VDM93390.1 - 1.2e-57 195.8 11.2 2.1e-46 158.7 2.8 2.0 1 1 1 2 2 2 2 Sodium:neurotransmitter symporter family Equine_IAV_S2 PF06502.11 VDM93390.1 - 0.19 11.8 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 Equine infectious anaemia virus S2 protein PA26 PF04636.13 VDM93396.1 - 2.7e-30 105.7 4.3 3.2e-30 105.4 4.3 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Methyltransf_8 PF05148.15 VDM93398.1 - 1.9e-68 230.6 0.2 2.1e-68 230.5 0.2 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 VDM93398.1 - 1.8e-08 34.9 0.0 1.3e-07 32.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 VDM93398.1 - 1.3e-06 29.0 0.0 0.00019 22.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 VDM93398.1 - 0.00014 21.7 0.3 0.23 11.2 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase domain MTS PF05175.14 VDM93398.1 - 0.00084 18.9 0.7 0.048 13.2 0.1 2.1 1 1 1 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 VDM93398.1 - 0.0083 15.5 0.3 0.25 10.6 0.0 2.5 1 1 2 3 3 3 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 VDM93398.1 - 0.029 13.5 0.1 0.039 13.1 0.1 1.3 1 1 0 1 1 1 0 NNMT/PNMT/TEMT family MetW PF07021.12 VDM93398.1 - 0.053 13.1 0.1 0.09 12.4 0.1 1.5 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 VDM93398.1 - 0.074 12.9 0.0 1 9.2 0.0 2.4 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 VDM93398.1 - 0.09 13.5 0.1 3 8.6 0.1 2.3 1 1 0 1 1 1 0 Methyltransferase domain DUF2451 PF10474.9 VDM93398.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) ASFV_J13L PF05568.11 VDM93405.1 - 0.11 12.2 8.0 0.12 12.1 8.0 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein RskA PF10099.9 VDM93405.1 - 0.24 11.7 13.7 0.26 11.6 13.7 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Tic110 PF16940.5 VDM93405.1 - 0.42 9.0 8.0 0.44 9.0 8.0 1.0 1 0 0 1 1 1 0 Chloroplast envelope transporter DUF2967 PF11179.8 VDM93405.1 - 4.8 5.1 10.9 4.7 5.2 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Asp PF00026.23 VDM93410.1 - 0.022 14.2 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic aspartyl protease Cyto_heme_lyase PF01265.17 VDM93418.1 - 2e-59 201.6 8.2 1.5e-58 198.7 8.2 1.9 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase HTH_10 PF04967.12 VDM93418.1 - 0.043 13.6 0.0 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 HTH DNA binding domain Zip PF02535.22 VDM93419.1 - 8.4e-14 51.5 55.0 9.2e-08 31.7 49.6 3.8 1 1 1 2 2 2 2 ZIP Zinc transporter Macoilin PF09726.9 VDM93419.1 - 1.8 7.0 9.4 2.4 6.6 9.4 1.3 1 0 0 1 1 1 0 Macoilin family Pkinase_Tyr PF07714.17 VDM93425.1 - 2.2e-12 46.9 0.0 2.8e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Rhodanese PF00581.20 VDM93435.1 - 5.6e-09 36.5 0.0 7.2e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain cNMP_binding PF00027.29 VDM93437.1 - 1.3e-06 28.4 0.1 2.4e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain TnsE_C PF18623.1 VDM93448.1 - 0.0033 17.4 0.3 0.0047 16.8 0.3 1.3 1 0 0 1 1 1 1 TnsE C-terminal domain IL17 PF06083.11 VDM93453.1 - 0.00035 21.0 0.7 0.00049 20.5 0.7 1.2 1 0 0 1 1 1 1 Interleukin-17 MFS_1 PF07690.16 VDM93454.1 - 0.024 13.5 0.0 0.024 13.5 0.0 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily YoaP PF14268.6 VDM93454.1 - 0.1 12.1 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 YoaP-like Herpes_U5 PF05999.11 VDM93465.1 - 0.15 10.8 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus U5-like family PA26 PF04636.13 VDM93469.1 - 1.9e-46 158.9 1.1 2.1e-46 158.7 1.1 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Ndc1_Nup PF09531.10 VDM93487.1 - 5.7 5.5 6.1 6.8 5.3 6.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Orthoreo_P10 PF07204.11 VDM93489.1 - 0.023 14.6 1.4 0.04 13.9 1.2 1.3 1 1 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Imm65 PF15582.6 VDM93497.1 - 0.073 11.9 0.0 0.095 11.5 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 65 KxDL PF10241.9 VDM93497.1 - 0.38 11.1 3.6 1.2 9.4 0.2 2.9 3 1 0 3 3 3 0 Uncharacterized conserved protein DUF4268 PF14088.6 VDM93497.1 - 0.95 9.3 5.5 0.2 11.5 1.5 1.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4268) Vps5 PF09325.10 VDM93500.1 - 0.055 13.0 0.1 0.065 12.8 0.1 1.0 1 0 0 1 1 1 0 Vps5 C terminal like DUF4164 PF13747.6 VDM93500.1 - 0.063 13.6 0.1 0.077 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Vps5 PF09325.10 VDM93504.1 - 0.055 13.0 0.1 0.065 12.8 0.1 1.0 1 0 0 1 1 1 0 Vps5 C terminal like DUF4164 PF13747.6 VDM93504.1 - 0.063 13.6 0.1 0.077 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) MFS_1 PF07690.16 VDM93505.1 - 6.9e-06 25.2 11.7 1.2e-05 24.4 11.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily BT1 PF03092.16 VDM93505.1 - 0.0098 14.2 0.1 0.0098 14.2 0.1 1.0 1 0 0 1 1 1 1 BT1 family Nuc_H_symport PF03825.16 VDM93505.1 - 0.38 9.7 3.0 0.78 8.6 3.0 1.6 1 1 0 1 1 1 0 Nucleoside H+ symporter Spectrin PF00435.21 VDM93506.1 - 1.8e-08 34.8 0.6 2.1e-07 31.4 0.1 2.1 2 0 0 2 2 2 1 Spectrin repeat SH3_9 PF14604.6 VDM93506.1 - 1.4e-07 31.3 0.5 2e-06 27.6 0.0 2.8 2 2 2 4 4 4 1 Variant SH3 domain SH3_1 PF00018.28 VDM93506.1 - 3.3e-07 29.8 0.1 9.9e-07 28.3 0.1 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 VDM93506.1 - 1.5e-06 27.8 0.0 5.5e-06 26.0 0.0 1.9 3 0 0 3 3 3 1 Variant SH3 domain SH3_3 PF08239.11 VDM93506.1 - 5.9e-05 23.3 0.7 0.00016 21.8 0.1 1.9 1 1 1 2 2 2 1 Bacterial SH3 domain SH3_10 PF17902.1 VDM93506.1 - 0.00057 19.9 0.0 0.0014 18.7 0.0 1.6 1 1 0 1 1 1 1 SH3 domain OB_RNB PF08206.11 VDM93506.1 - 0.062 13.0 0.1 0.78 9.5 0.0 2.4 2 1 0 2 2 2 0 Ribonuclease B OB domain hSH3 PF14603.6 VDM93506.1 - 0.071 13.5 0.1 0.23 11.9 0.0 1.8 1 1 1 2 2 2 0 Helically-extended SH3 domain 7tm_1 PF00001.21 VDM93507.1 - 9.2e-25 87.4 3.4 9.2e-25 87.4 3.4 1.3 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) 7TM_GPCR_Srsx PF10320.9 VDM93507.1 - 5.6e-09 35.7 5.5 7.4e-09 35.4 5.5 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx 7TM_GPCR_Srx PF10328.9 VDM93507.1 - 7.9e-07 29.0 8.9 9.3e-07 28.7 8.9 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx Rax2 PF12768.7 VDM93507.1 - 0.14 11.6 1.1 0.2 11.1 1.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Ammonium_transp PF00909.21 VDM93530.1 - 7e-07 28.3 1.8 7e-07 28.3 1.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Gp_dh_N PF00044.24 VDM93533.1 - 1.6e-30 105.4 0.1 1.9e-30 105.2 0.1 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 VDM93533.1 - 0.0069 15.8 0.0 0.0082 15.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DapB_N PF01113.20 VDM93533.1 - 0.012 15.7 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF1664 PF07889.12 VDM93543.1 - 0.044 13.8 1.4 0.19 11.8 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LEF-8 PF04941.12 VDM93543.1 - 0.076 11.3 0.1 0.084 11.1 0.1 1.0 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) Myosin_head PF00063.21 VDM93552.1 - 2.6e-08 32.6 0.0 2.7e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) ANAPC9 PF12856.7 VDM93552.1 - 0.14 12.4 0.1 0.27 11.4 0.1 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 9 DUF2465 PF10239.9 VDM93558.1 - 0.0077 15.5 0.8 0.0086 15.3 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) DUF1678 PF07913.11 VDM93558.1 - 0.0093 15.8 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1678) 7TM_GPCR_Srx PF10328.9 VDM93561.1 - 2e-22 80.1 7.1 2.2e-22 80.0 7.1 1.0 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srx MRAP PF15183.6 VDM93561.1 - 0.004 17.1 0.8 0.0053 16.7 0.8 1.3 1 0 0 1 1 1 1 Melanocortin-2 receptor accessory protein family Spectrin PF00435.21 VDM93568.1 - 2.8e-19 69.5 13.6 3.5e-14 53.1 5.8 2.6 3 0 0 3 3 3 2 Spectrin repeat T4SS_TraI PF16932.5 VDM93568.1 - 0.013 14.7 0.1 0.024 13.8 0.1 1.3 1 0 0 1 1 1 0 Type IV secretory system, conjugal DNA-protein transfer AAA_lid_7 PF17867.1 VDM93568.1 - 0.023 14.9 0.5 0.33 11.2 0.2 2.2 1 1 1 2 2 2 0 Midasin AAA lid domain Cytochrom_C_2 PF01322.20 VDM93568.1 - 0.044 14.7 2.0 0.069 14.1 1.3 1.9 1 1 1 2 2 2 0 Cytochrome C' DUF4795 PF16043.5 VDM93568.1 - 0.048 13.3 1.7 0.11 12.1 1.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF1090 PF06476.12 VDM93568.1 - 0.35 11.0 0.1 0.35 11.0 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1090) Motile_Sperm PF00635.26 VDM93571.1 - 1.3e-22 79.7 0.0 1.4e-22 79.5 0.0 1.0 1 0 0 1 1 1 1 MSP (Major sperm protein) domain Sortase PF04203.13 VDM93571.1 - 0.16 11.8 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 Sortase domain MIP PF00230.20 VDM93572.1 - 0.014 15.1 0.3 0.017 14.9 0.3 1.1 1 0 0 1 1 1 0 Major intrinsic protein Ceramidase PF05875.12 VDM93572.1 - 0.033 13.6 0.2 0.035 13.5 0.2 1.1 1 0 0 1 1 1 0 Ceramidase HEAT PF02985.22 VDM93575.1 - 0.064 13.6 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 HEAT repeat Arf PF00025.21 VDM93579.1 - 1.3e-16 60.6 0.0 1.4e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF3673 PF12425.8 VDM93579.1 - 0.071 13.0 0.1 0.1 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) zf-C2H2 PF00096.26 VDM93586.1 - 5.1e-06 26.7 0.6 5.1e-06 26.7 0.6 2.3 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 VDM93586.1 - 0.0018 18.2 1.9 0.0042 17.0 1.9 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 VDM93586.1 - 0.0068 17.1 0.6 0.0068 17.1 0.6 2.4 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2HC_2 PF13913.6 VDM93586.1 - 0.033 14.1 0.4 1.9 8.5 0.1 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Myosin_head PF00063.21 VDM93596.1 - 2.5e-12 45.9 0.2 2.7e-12 45.7 0.2 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) HemN_C PF06969.16 VDM93596.1 - 0.0082 16.2 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 HemN C-terminal domain Actin PF00022.19 VDM93598.1 - 5.2e-80 269.0 0.0 2.4e-79 266.9 0.0 1.8 1 1 0 1 1 1 1 Actin Myosin_head PF00063.21 VDM93613.1 - 1.9e-07 29.8 0.2 1.9e-07 29.8 0.2 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) DUF5528 PF17666.1 VDM93613.1 - 0.11 12.4 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5528) fn3 PF00041.21 VDM93624.1 - 0.00067 20.0 0.5 1.7 9.1 0.1 2.9 2 1 0 2 2 2 2 Fibronectin type III domain ComFB PF10719.9 VDM93642.1 - 0.012 15.7 0.7 0.02 15.0 0.7 1.3 1 0 0 1 1 1 0 Late competence development protein ComFB DUF1962 PF09227.10 VDM93651.1 - 0.081 13.3 0.0 0.095 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1962) Unstab_antitox PF09720.10 VDM93651.1 - 0.11 12.5 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative addiction module component Mesd PF10185.9 VDM93664.1 - 8.2e-10 38.8 5.2 9.1e-10 38.7 5.2 1.1 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor DUF4205 PF13898.6 VDM93683.1 - 0.14 11.1 0.1 0.14 11.1 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4205) Ank_4 PF13637.6 VDM93685.1 - 1.6e-10 41.3 0.2 9.5e-10 38.8 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 VDM93685.1 - 1.1e-09 38.8 0.1 1.3e-08 35.3 0.1 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 VDM93685.1 - 1.3e-08 34.4 0.1 0.0016 18.8 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 VDM93685.1 - 6.9e-08 32.6 0.1 0.089 13.3 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 VDM93685.1 - 8.4e-06 26.0 0.1 0.00019 21.7 0.1 2.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) DUF249 PF03158.13 VDM93685.1 - 0.03 14.0 0.1 0.041 13.6 0.1 1.4 1 1 0 1 1 1 0 Multigene family 530 protein VWD PF00094.25 VDM93695.1 - 0.00074 19.8 0.0 0.0012 19.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type D domain Globin PF00042.22 VDM93703.1 - 5e-30 104.3 0.0 6.3e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Globin Big_8 PF17961.1 VDM93703.1 - 0.11 12.6 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial Ig domain VWD PF00094.25 VDM93734.1 - 1.9e-08 34.8 0.2 2.3e-08 34.5 0.2 1.1 1 0 0 1 1 1 1 von Willebrand factor type D domain DUF3716 PF12511.8 VDM93756.1 - 0.024 14.7 0.1 0.027 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3716) Abhydrolase_1 PF00561.20 VDM93789.1 - 6.3e-06 26.0 0.0 6.3e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 VDM93789.1 - 0.013 14.7 0.0 0.014 14.7 0.0 1.0 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ribosomal_L14e PF01929.17 VDM93789.1 - 0.076 13.5 0.0 0.083 13.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L14 # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Litomosoides_sigmodontis-ASM90053727v1/GCA_900537275.1_ASM90053727v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Litomosoides_sigmodontis-ASM90053727v1/GCA_900537275.1_ASM90053727v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Litomosoides_sigmodontis-ASM90053727v1/GCA_900537275.1_ASM90053727v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Metazoa/Nematods/Litomosoides_sigmodontis-ASM90053727v1/GCA_900537275.1_ASM90053727v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 17:49:30 2019 # [ok]